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DerAnaesthesist.60451093.eng.abstr
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DerAnaesthesist.60451093.eng.abstr
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"We report the case of a 35-year-old male who was admitted to the intensive care unit because of somnolence due to accidental hypothermia . Initial examination showed a Glasgow coma score of 10 and a rectal temperature of 27.4 ° C. Because of stable circulatory conditions , there was no mandatory indication for rewarming by means of cardiopulmonary bypass . We rewarmed the patient with an extracorporeal veno-venous haemofiltration device combined with a countercurrent fluid warmer . An average increase in body temperature of 1.34 ° Ch-1 could be obtained . We conclude that the described technique represents an effective and well-controllable method for treatment of hypothermia in patients with stable haemodynamic conditions . Because of the availability of the required equipment , this method can also be practised in hospitals without cardiac surgical departments and cardiopulmonary bypass facilities ."
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DerAnaesthesist.60451097.eng.abstr
|
DerAnaesthesist.60451097.eng.abstr
|
[
{
"id": "DerAnaesthesist.60451097.eng.abstr-passage-0",
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"text": [
"Treatment of pulmonary hypertension is an important issue in intensive care . One therapeutic regimen involves the intravenous administration of prostacyclin ( PGI2). This , however , is accompanied by diminished hypoxic pulmonary vasoconstriction , reduced arterial oxygenation , and systemic vasodilation . Thus , its clinical usefulness is limited . However , the inhalation of vasodilators such as nitric oxide ( NO ) or nebulized PGI2 causes a selective pulmonary vasodilation in ventilated alveoli and improved gas exchange , without any systemic vasodilation . It has therefore gained importance for the treatment of pulmonary failure associated with high shunt fractions . However , the inhalation of vasodilators may have adverse effects : in the case of NO , toxic side effects are predominant ( MetHb , NOx ) , whereas in the case of PGI2, technical problems in terms of dosing and administration safety are of major interest . Furthermore , some patients do not respond to the treatment . In some individuals a reduction in pulmonary hypertension can be seen , while others lack even pulmonary vasodilation . The exact pathophysiological mechanisms remain to be investigated ."
],
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[
0,
1188
]
]
}
] |
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[] |
[] |
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},
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},
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},
{
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},
{
"id": "DerAnaesthesist.60451097.eng.abstr-s8-r7-t1.1-t3.1",
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"normalized": []
}
] |
DerAnaesthesist.60451142.eng.abstr
|
DerAnaesthesist.60451142.eng.abstr
|
[
{
"id": "DerAnaesthesist.60451142.eng.abstr-passage-0",
"type": "abstract",
"text": [
"During the last five years several authors have reported largely satisfactory results , using the steroid intravenous anaesthetic eltanolone ( pregnanolone ) for induction of anaesthesia after administering a bolus dose . Until now , however , no investigations have been undertaken , dealing with the infusion pharmacokinetics of eltanolone after arterial blood sampling and using slow induction to quantify the concentration-effect relationship . Secondary objectives were to assess the haemodynamic and respiratory effects ."
],
"offsets": [
[
0,
527
]
]
}
] |
[
{
"id": "DerAnaesthesist.60451142.eng.abstr-s1-t1",
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"text": [
"steroid"
],
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[
98,
105
]
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{
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"db_id": "C0038317"
}
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},
{
"id": "DerAnaesthesist.60451142.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"anaesthetic"
],
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[
118,
129
]
],
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{
"db_name": "UMLS",
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}
]
},
{
"id": "DerAnaesthesist.60451142.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"pregnanolone"
],
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[
143,
155
]
],
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{
"db_name": "UMLS",
"db_id": "C0033008"
}
]
},
{
"id": "DerAnaesthesist.60451142.eng.abstr-s1-t4",
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"intravenous anaesthetic"
],
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[
106,
129
]
],
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{
"db_name": "UMLS",
"db_id": "C0242904"
}
]
},
{
"id": "DerAnaesthesist.60451142.eng.abstr-s2-t1",
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"text": [
"pharmacokinetics"
],
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[
311,
327
]
],
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{
"db_name": "UMLS",
"db_id": "C0031327"
},
{
"db_name": "UMLS",
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}
]
},
{
"id": "DerAnaesthesist.60451142.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"blood"
],
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[
357,
362
]
],
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{
"db_name": "UMLS",
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},
{
"db_name": "UMLS",
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},
{
"db_name": "UMLS",
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}
]
},
{
"id": "DerAnaesthesist.60451142.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"concentration-effect"
],
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[
413,
433
]
],
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{
"db_name": "UMLS",
"db_id": "C0086045"
}
]
},
{
"id": "DerAnaesthesist.60451142.eng.abstr-s3-t1",
"type": "umlsterm",
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"Secondary"
],
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[
449,
458
]
],
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{
"db_name": "UMLS",
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},
{
"db_name": "UMLS",
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}
]
},
{
"id": "DerAnaesthesist.60451142.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"objectives"
],
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[
459,
469
]
],
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{
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}
]
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{
"id": "DerAnaesthesist.60451142.eng.abstr-s3-t3",
"type": "umlsterm",
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"haemodynamic"
],
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[
489,
501
]
],
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{
"db_name": "UMLS",
"db_id": "C0019010"
}
]
}
] |
[] |
[] |
[
{
"id": "DerAnaesthesist.60451142.eng.abstr-s1-r1-t3.1-t4.1",
"type": "interacts_with",
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},
{
"id": "DerAnaesthesist.60451142.eng.abstr-s1-r5-t3.1-t1.1",
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},
{
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},
{
"id": "DerAnaesthesist.60451142.eng.abstr-s1-r7-t1.1-t4.1",
"type": "interacts_with",
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},
{
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},
{
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},
{
"id": "DerAnaesthesist.60451142.eng.abstr-s1-r10-t1.1-t3.1",
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},
{
"id": "DerAnaesthesist.60451142.eng.abstr-s2-r1-t3.1-t2.2",
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},
{
"id": "DerAnaesthesist.60451142.eng.abstr-s2-r3-t1.1-t3.1",
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},
{
"id": "DerAnaesthesist.60451142.eng.abstr-s2-r4-t1.2-t3.1",
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},
{
"id": "DerAnaesthesist.60451142.eng.abstr-s2-r5-t1.2-t3.1",
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},
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},
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},
{
"id": "DerAnaesthesist.60451142.eng.abstr-s2-r8-t3.1-t1.1",
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},
{
"id": "DerAnaesthesist.60451142.eng.abstr-s2-r9-t1.2-t2.2",
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},
{
"id": "DerAnaesthesist.60451142.eng.abstr-s3-r1-t1.1-t3.1",
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},
{
"id": "DerAnaesthesist.60451142.eng.abstr-s3-r2-t3.1-t1.1",
"type": "result_of",
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"arg2_id": "DerAnaesthesist.60451142.eng.abstr-s3-t1",
"normalized": []
}
] |
DerAnaesthesist.60451151.eng.abstr
|
DerAnaesthesist.60451151.eng.abstr
|
[
{
"id": "DerAnaesthesist.60451151.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Major abdominal surgery often leads to a marked sympathoadrenal stress response with high concentrations of plasma catecholamines , hypertension , and tachycardia . We compared the effects of sufentanil-propofol with fentanyl-propofol anaesthesia in a controlled , randomised , double-blind study of 18 ASA I-II patients aged 23-64 years undergoing major abdominal surgery . Study parameters were haemodynamics ( heart rate [ HR ] , arterial [ ABP ] , central venous , and pulmonary arterial pressures , cardiac index [ CI ] ) , arterial catecholamine concentrations , and the median frequency of the electroencephalogram ( EEG ) power spectrum ."
],
"offsets": [
[
0,
646
]
]
}
] |
[
{
"id": "DerAnaesthesist.60451151.eng.abstr-s1-t1",
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"text": [
"surgery"
],
"offsets": [
[
16,
23
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0038894"
},
{
"db_name": "UMLS",
"db_id": "C0038895"
}
]
},
{
"id": "DerAnaesthesist.60451151.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"stress"
],
"offsets": [
[
64,
70
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0038435"
}
]
},
{
"id": "DerAnaesthesist.60451151.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"concentrations"
],
"offsets": [
[
90,
104
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0086045"
}
]
},
{
"id": "DerAnaesthesist.60451151.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"plasma"
],
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[
108,
114
]
],
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{
"db_name": "UMLS",
"db_id": "C0032105"
}
]
},
{
"id": "DerAnaesthesist.60451151.eng.abstr-s1-t5",
"type": "umlsterm",
"text": [
"catecholamines"
],
"offsets": [
[
115,
129
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0007412"
}
]
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{
"id": "DerAnaesthesist.60451151.eng.abstr-s1-t6",
"type": "umlsterm",
"text": [
"hypertension"
],
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[
132,
144
]
],
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{
"db_name": "UMLS",
"db_id": "C0020538"
}
]
},
{
"id": "DerAnaesthesist.60451151.eng.abstr-s1-t7",
"type": "umlsterm",
"text": [
"tachycardia"
],
"offsets": [
[
151,
162
]
],
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{
"db_name": "UMLS",
"db_id": "C0039231"
}
]
},
{
"id": "DerAnaesthesist.60451151.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"sufentanil-propofol"
],
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[
192,
211
]
],
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"db_name": "UMLS",
"db_id": "C0143993"
}
]
},
{
"id": "DerAnaesthesist.60451151.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"sufentanil-propofol"
],
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[
192,
211
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0033487"
}
]
},
{
"id": "DerAnaesthesist.60451151.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"fentanyl-propofol"
],
"offsets": [
[
217,
234
]
],
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{
"db_name": "UMLS",
"db_id": "C0015846"
}
]
},
{
"id": "DerAnaesthesist.60451151.eng.abstr-s2-t4",
"type": "umlsterm",
"text": [
"fentanyl-propofol"
],
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[
217,
234
]
],
"normalized": [
{
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"db_id": "C0033487"
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},
{
"id": "DerAnaesthesist.60451151.eng.abstr-s2-t5",
"type": "umlsterm",
"text": [
"ASA"
],
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[
303,
306
]
],
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{
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"db_id": "C0004057"
}
]
},
{
"id": "DerAnaesthesist.60451151.eng.abstr-s2-t6",
"type": "umlsterm",
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"patients"
],
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[
312,
320
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0030705"
}
]
},
{
"id": "DerAnaesthesist.60451151.eng.abstr-s2-t7",
"type": "umlsterm",
"text": [
"surgery"
],
"offsets": [
[
365,
372
]
],
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"db_id": "C0038894"
},
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]
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{
"id": "DerAnaesthesist.60451151.eng.abstr-s2-t8",
"type": "umlsterm",
"text": [
"double-blind study"
],
"offsets": [
[
278,
296
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0013072"
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]
},
{
"id": "DerAnaesthesist.60451151.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"haemodynamics"
],
"offsets": [
[
397,
410
]
],
"normalized": [
{
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"db_id": "C0019010"
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]
},
{
"id": "DerAnaesthesist.60451151.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"heart"
],
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[
413,
418
]
],
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{
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"db_id": "C0018787"
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]
},
{
"id": "DerAnaesthesist.60451151.eng.abstr-s3-t3",
"type": "umlsterm",
"text": [
"ABP"
],
"offsets": [
[
444,
447
]
],
"normalized": [
{
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"db_id": "C0001239"
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]
},
{
"id": "DerAnaesthesist.60451151.eng.abstr-s3-t4",
"type": "umlsterm",
"text": [
"pressures"
],
"offsets": [
[
492,
501
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0033095"
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]
},
{
"id": "DerAnaesthesist.60451151.eng.abstr-s3-t5",
"type": "umlsterm",
"text": [
"index"
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"offsets": [
[
512,
517
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],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0021200"
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{
"db_name": "UMLS",
"db_id": "C0918012"
}
]
},
{
"id": "DerAnaesthesist.60451151.eng.abstr-s3-t6",
"type": "umlsterm",
"text": [
"catecholamine"
],
"offsets": [
[
538,
551
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0007412"
}
]
},
{
"id": "DerAnaesthesist.60451151.eng.abstr-s3-t7",
"type": "umlsterm",
"text": [
"concentrations"
],
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] |
DerAnaesthesist.60451158.eng.abstr
|
DerAnaesthesist.60451158.eng.abstr
|
[
{
"id": "DerAnaesthesist.60451158.eng.abstr-passage-0",
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"text": [
"The purpose of the present study was to compare two sedation regimens with either propofol ( P ) or methohexital ( M ) for elective magnetic resonance imaging ( MRI ) in children with respect to safety , side effects , recovery , and discharge time ."
],
"offsets": [
[
0,
250
]
]
}
] |
[
{
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],
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82,
90
]
],
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},
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112
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140
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170,
178
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DerAnaesthesist.60451167.eng.abstr
|
DerAnaesthesist.60451167.eng.abstr
|
[
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"id": "DerAnaesthesist.60451167.eng.abstr-passage-0",
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"Pollution of work areas by volatile anaesthetics and nitrous oxide occurs during general anaesthesia . Short anaesthesia procedures are often carried out in operating theatres that are not equipped with air-conditioning systems . Methods of lovering exposure during short procedures , where mask anaesthesia is the usual procedure , are double masks and the laryngeal mask . The aim of our investigation was to determine the possibility of lowering the pollution of the environment to below national and international thresholds in a non-air-conditioned work area and to find out which method of anaesthesia is the most effective in environmental protection , i.e. which has the lowest leakage rate ."
],
"offsets": [
[
0,
700
]
]
}
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[] |
[] |
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DerAnaesthesist.60451171.eng.abstr
|
DerAnaesthesist.60451171.eng.abstr
|
[
{
"id": "DerAnaesthesist.60451171.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Human recombinant interleukin 2 ( IL-2), alone or in combination with other cytokines , is currently under investigation for the immunotherapy of metastatic tumours . Objective responses of 20%-35% have been reported in patients with disseminated melanoma and renal cell carcinoma who received high-dose intravenous IL-2 in combination with interferon- ( IFN ) . However , treatment with IL-2 is complicated by a syndrome of life-threatening adverse reactions such as disseminated vascular leakage , fluid retention , severe hypotension , and ( reversible ) multiple organ dysfunction ( MODS ) . A systemic inflammatory reaction ( SIRS ) /sepsis sepsis-like haemodynamic pattern has been described in patients after IL-2 bolus application alone . Our purpose was to study the haemodynamic changes in patients treated with high-dose IL-2 administered as a constant infusion and in combination with IFN ."
],
"offsets": [
[
0,
902
]
]
}
] |
[
{
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"id": "DerAnaesthesist.60451171.eng.abstr-s1-t2",
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"interleukin"
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"cytokines"
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"immunotherapy"
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{
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"tumours"
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157,
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"id": "DerAnaesthesist.60451171.eng.abstr-s1-t7",
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"id": "DerAnaesthesist.60451171.eng.abstr-s2-t1",
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"id": "DerAnaesthesist.60451171.eng.abstr-s2-t3",
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"id": "DerAnaesthesist.60451171.eng.abstr-s2-t4",
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{
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{
"id": "DerAnaesthesist.60451171.eng.abstr-s2-t6",
"type": "umlsterm",
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"IL-2"
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{
"id": "DerAnaesthesist.60451171.eng.abstr-s2-t7",
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"IFN"
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"id": "DerAnaesthesist.60451171.eng.abstr-s2-t9",
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260,
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{
"id": "DerAnaesthesist.60451171.eng.abstr-s3-t2",
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{
"id": "DerAnaesthesist.60451171.eng.abstr-s3-t5",
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{
"id": "DerAnaesthesist.60451171.eng.abstr-s3-t6",
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"id": "DerAnaesthesist.60451171.eng.abstr-s3-t7",
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"id": "DerAnaesthesist.60451171.eng.abstr-s4-t1",
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]
}
] |
[] |
[] |
[
{
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},
{
"id": "DerAnaesthesist.60451171.eng.abstr-s5-r6-t4.1-t3.1",
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] |
DerAnaesthesist.60451179.eng.abstr
|
DerAnaesthesist.60451179.eng.abstr
|
[
{
"id": "DerAnaesthesist.60451179.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Although still rare , pregnancy and delivery in women with spinal cord injuries is becoming more frequent ( Table 2 ) . In 85%-90% of patients with lesions above T6 symptoms of autonomic hyperreflexia ( Table 1 ) , especially paroxysmal and excessive increases in arterial blood pressure , may occur . In anaesthesising a 31-year-old paraplegic primigravida with a complete transverse spinal lesion at T4 for an elective caesarean section , no indication of hypertonic cardiovascular dysregulation either intra- or postoperatively was observed after repeated epidural administration of bupivacaine . Distinct intraoperative spasticity of the abdominal wall muscles was , however , not influenced by the dosages selected ."
],
"offsets": [
[
0,
721
]
]
}
] |
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"pregnancy"
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22,
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{
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"delivery"
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"women"
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48,
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"injuries"
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"spinal cord"
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},
{
"id": "DerAnaesthesist.60451179.eng.abstr-s1-t6",
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59,
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"id": "DerAnaesthesist.60451179.eng.abstr-s2-t1",
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},
{
"id": "DerAnaesthesist.60451179.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"hyperreflexia"
],
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187,
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},
{
"id": "DerAnaesthesist.60451179.eng.abstr-s2-t4",
"type": "umlsterm",
"text": [
"blood"
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"id": "DerAnaesthesist.60451179.eng.abstr-s2-t5",
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"pressure"
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{
"id": "DerAnaesthesist.60451179.eng.abstr-s2-t6",
"type": "umlsterm",
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"autonomic hyperreflexia"
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"id": "DerAnaesthesist.60451179.eng.abstr-s2-t7",
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"blood pressure"
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273,
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{
"id": "DerAnaesthesist.60451179.eng.abstr-s3-t1",
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"administration"
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},
{
"id": "DerAnaesthesist.60451179.eng.abstr-s3-t2",
"type": "umlsterm",
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"bupivacaine"
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586,
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"id": "DerAnaesthesist.60451179.eng.abstr-s3-t3",
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"id": "DerAnaesthesist.60451179.eng.abstr-s4-t1",
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"id": "DerAnaesthesist.60451179.eng.abstr-s4-t2",
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"id": "DerAnaesthesist.60451179.eng.abstr-s4-t4",
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{
"db_name": "UMLS",
"db_id": "C0000739"
}
]
}
] |
[] |
[] |
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DerAnaesthesist.60451184.eng.abstr
|
DerAnaesthesist.60451184.eng.abstr
|
[
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0,
275
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}
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[] |
[] |
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DerAnaesthesist.60451196.eng.abstr
|
DerAnaesthesist.60451196.eng.abstr
|
[
{
"id": "DerAnaesthesist.60451196.eng.abstr-passage-0",
"type": "abstract",
"text": [
"In prehospital emergency treatment , the timely establishment of a secure vascular access , especially in infants and small children , can be difficult or even impossible . An alternative to the puncture of peripheral or central veins is intraosseous ( IO ) puncture [ 6 , 7 ] . However , experience with this method in prehospital emergency medicine within the Federal Republic of Germany is extremely limited at present [ 25 ] . After intensive theoretical and practical training of our trauma anaesthesiologists , IO puncture was introduced in our rescue helicopter program \" Christoph 22 \" as an alternative to peripheral or central venous puncture in the prehospital treatment of patients up to 6 years of age . IO puncture is indicated after a maximum of three failed peripheral venous puncture attempts . The purpose of this study was to collect data and summarise first-hand experience on the prehospital use of the IO method as well as the practicability of our prescribed IO puncture algorithm in order to subject them to critical review and evaluation ."
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0,
1064
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] |
DerAnaesthesist.60451211.eng.abstr
|
DerAnaesthesist.60451211.eng.abstr
|
[
{
"id": "DerAnaesthesist.60451211.eng.abstr-passage-0",
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"The objectives of the present study were to compare in a randomized double-blind crossover study design the concentration-effect relationships of Ro 48-6791 , a new benzodiazepine agonist , and midazolam , following infusion in young and elderly male volunteers . Therefore , linearly increasing plasma concentrations were generated by computer controlled infusion pumps to achieve a deep hypnotic effect . The endpoint of the infusion was defined by loss of response to loud verbal commands and a median frequency of the recorded EEG power spectrum below 4 Hz. Arterial blood samples were collected in regular intervals up to 6 hours after cessation of the infusion . The method of pharmacokinetic-pharmacodynamic modeling was used to quantify the concentration-effect relationship , including age related differences , already in this early phase I study . The total clearance of Ro 48-6791 was found to be 1410 +/- 380 vs. 399 +/- 91 ml min-1 for midazolam ( mean +/- SD ; P 0.005 ) and the central volume of distribution to be 20.5 +/- 7.1 vs. 7.9 +/- 3.0 l , respectively ( P 0.005 ) . The comparison between young and elderly volunteers yielded for Ro 48-6791 a statistically not significant reduction of 16% for clearance with age and a slowed distribution of 47% for midazolam ( P 0.05 ) . The recovery period for Ro 48-6791 was reduced by 66% ( P 0.005 ) in the young and 45% ( P 0.01 ) in the elderly , respectively , in comparison with midazolam . With respect to the total doses administered , Ro 48-6791 appeared to be 2.5 times as potent as midazolam in all volunteers ( P 0.001 ) . Comparing both age groups , the doses necessary to cause similar effects were reduced by one half for both compounds in the elderly ( P 0.001 ) . The major advantages of Ro 48-6791 compared to midazolam were its shorter duration of action as well as the faster recovery and thus the better controllability . Further investigations would have to confirm these results in a greater number of patients . The applied method of pharmacokinetic-pharmacodynamic modeling not only allowed to quantify the efficacy of Ro 48-6791 but also provided data to augment the safety for further investigations ."
],
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0,
2190
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] |
DerAnaesthesist.70460003.eng.abstr
|
DerAnaesthesist.70460003.eng.abstr
|
[
{
"id": "DerAnaesthesist.70460003.eng.abstr-passage-0",
"type": "abstract",
"text": [
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[] |
[] |
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DerAnaesthesist.70460014.eng.abstr
|
DerAnaesthesist.70460014.eng.abstr
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[
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"id": "DerAnaesthesist.70460014.eng.abstr-passage-0",
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"text": [
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0,
658
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] |
[] |
[] |
[
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DerAnaesthesist.70460021.eng.abstr
|
DerAnaesthesist.70460021.eng.abstr
|
[
{
"id": "DerAnaesthesist.70460021.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The economic impact of the new German health care laws requires an awareness of cost-effectiveness when using newer drugs . The main goal in patient care , i.e. , effective treatment , must be achieved by the rational use of restricted resources at a maximum degree of effectiveness . Economic aspects of the new inhalational anaesthetics such as sevoflurane are discussed in this article . The cost of inhalational anaesthetic agents accounts for up to 5% of all the running expenses of an anaesthesia department . The consumption and cost of an inhalational agent depend on fresh gas flow , vapour setting , and duration of anaesthesia . Comparing the cost for 1 MAC-h of anaesthesia , desflurane is more expensive at current market prices than sevoflurane and isoflurane . However , at low or minimal fresh-gas flows , the price for one MAC-h is almost the same for these volatile anaesthetics . Total intravenous anaesthesia using propofol is even more expensive , partly due to wastage , i.e. , opened ampoules with a remainder of propofol that has to be discarded after each case . When choosing an anaesthetic agent , the price of 1 ml liquid anaesthetic is an important factor . However , the overall cost-effectiveness analysis must balance the cost of the agent with its pharmacodynamic advantages such as more rapid recovery from anaesthesia . Furthermore , the indirect costs of side effects have to be taken into account . For example , nausea and vomiting lead to a prolonged stay in the recovery room after anaesthesia for outpatient surgery , which in turn incurs additional costs for antiemetic drugs and the extra time for nursing care . Therefore , a lower incidence of nausea and vomiting and a more rapid recovery from anaesthesia leading to earlier discharge from the recovery room may compensate for the higher price . Volatile agents account for up to 1% of the total intraoperative costs . In analysing the costs of 1 h of anaesthesia , other products such as plasma substitutes and blood products account for a much higher proportion than anaesthetic agents , and reductions or increases in costs pertaining to these products have a bigger impact on overall costs than do volatile anaesthetics . We conclude that volatile anaesthetics account for only a minor portion of the anaesthesia department budget and the cost of anaesthesia delivery . The higher market price of the new agents may be compensated for by the economic impact of fewer side effects and a shorter post-anaesthesia stay in the hospital . In analysing data for sevoflurane , this agent may be cost-effective , for example , for outpatient anaesthesia ."
],
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0,
2647
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] |
DerAnaesthesist.70460029.eng.abstr
|
DerAnaesthesist.70460029.eng.abstr
|
[
{
"id": "DerAnaesthesist.70460029.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Methods : Using transcranial Doppler sonography ( TCD ) , we studied the effects of sevoflurane compared to equipotent doses of isoflurane on blood-flow velocity in the middle cerebral artery ( MCA ) before , during , and after general anaesthesia . In random order , 30 patients received sevoflurane ( n=15) or isoflurane ( n=15) given in stepwise-increasing doses of 0.5 , 1.0 , and 1.5 MAC in oxygen/air ( FiO2=0.5). Oxygen/air was then replaced by oxygen/nitrous oxide 33%/65% with decreasing doses ( 1.5 , 1.0 , 0.5 MAC ) of sevoflurane or isoflurane . During each step , ventilation was controlled to provide first normocapnia ( end-tidal pCO2=38 mmHg ) and then hypocapnia ( end-tidal pCO2=27 mmHg ) . MCA blood-flow velocity and pulsatility , arterial blood pressure , heart rate , and body temperature were recorded simultaneously at the end of each period . For statistical analysis , within-group comparison was made by one-way ANOVA . Differences between groups were determined by two-way analysis of variance . Age , weight , and height of the patients were compared using Student's t-test ; P 0.05 was considered significant ."
],
"offsets": [
[
0,
1140
]
]
}
] |
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"id": "DerAnaesthesist.70460029.eng.abstr-s1-t2",
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"sevoflurane"
],
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84,
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],
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"blood-flow"
],
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142,
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]
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"artery"
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"id": "DerAnaesthesist.70460029.eng.abstr-s1-t7",
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"MCA"
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194,
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},
{
"id": "DerAnaesthesist.70460029.eng.abstr-s1-t8",
"type": "umlsterm",
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"general anaesthesia"
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"id": "DerAnaesthesist.70460029.eng.abstr-s2-t4",
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] |
[] |
[] |
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"id": "DerAnaesthesist.70460029.eng.abstr-s1-r12-t7.1-t3.1",
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] |
DerAnaesthesist.70460034.eng.abstr
|
DerAnaesthesist.70460034.eng.abstr
|
[
{
"id": "DerAnaesthesist.70460034.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Background : We report a case of irreversible unilateral hypoglossal nerve palsy in connection with nasal septum surgery in intubation anaesthesia . On account of the spatial distance , there is no danger of injuring the hypoglossal nerve during nasal surgery . However , in the otorhinolaryngological and anaesthesiological literature , some cases of hypoglossal palsy following endotracheal intubation , use of the laryngeal mask airway , bronchoscopy and laryngoscopy are reported ."
],
"offsets": [
[
0,
485
]
]
}
] |
[
{
"id": "DerAnaesthesist.70460034.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"nerve"
],
"offsets": [
[
69,
74
]
],
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DerAnaesthesist.70460038.eng.abstr
|
DerAnaesthesist.70460038.eng.abstr
|
[
{
"id": "DerAnaesthesist.70460038.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Life-threatening cardiovascular complications are a serious risk even for healthy patients during spinal/epidural anaesthesia . The incidence of fatal cardiovascular complications for epidural anaesthesia is 1:10000 , for spinal anaesthesia 1:7000 . In contrast , general anaesthesia has an overall mortality of only 1:28000 . Administration of IV fluids to minimise the haemodynaemic reactions of beginning sympatholysis is not always sufficient . In this study , we examined whether fractionated application of local anaesthetics via a spinal catheter would provide better haemodynamic stability ."
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0,
599
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}
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] |
[] |
[] |
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DerAnaesthesist.70460043.eng.abstr
|
DerAnaesthesist.70460043.eng.abstr
|
[
{
"id": "DerAnaesthesist.70460043.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The authors report a rare , recently diagnosed and atypical mishap during one-lung ventilation ( OLV ) via a double lumen tube ( DLT ) and left-sided thoracotomy : an ipsilateral pneumothorax during ventilation of the right lung . This occurred in a 63-year-old patient with chronic obstructive airway disease who was scheduled for urgent repair of a descending thoracic aortic aneurysm . Anaesthesia and surgery were uneventful until aortic cross-clamping release . The common presentation of increased intrathoracic extrapleural pressure owing to a pneumothorax in patients with mechanically ventilated lungs is a rapid decrease in oxygen saturation , followed or paralleled by haemodynamic deterioration . Although the above presentation could be seen in this case , the diagnosis of a tension pneumothorax was delayed twice . First , symptoms were initially obscured by haemodynamic changes resulting from a head-down tilt and aortic declamping . Second , since the lack of consolidation after aortic declamping focused attention on the airway problems , complications resulting from the use of a DLT were primarily considered . In particular , since breathing sounds were detectable initially , malposition or torsion of the DLT had to be excluded by fibre-optic bronchoscopy , which involved a further delay . Finally , two observations led to the diagnosis of a right-sided tension pneumothorax : ( 1 ) bullae of the contralateral lung , detected during thoracotomy ; ( 2 ) the finding that ventilation of both lungs and the left lung subsequently increased arterial ( SaO2) and mixed venous oxygen saturation ( SvO2) and the circulatory status , but ventilation of the right lung caused a deterioration . Chest radiography and insertion of a chest tube with drainage of air , thereafter , validated our hypothesis . The time course of oxygen desaturation during OLV and tension pneumothorax was as severe as expected ; the time course of haemodynamic deterioration , however , appeared quicker and had more impact than expected . Assuming that mediastinal deviation was not hindered by contralateral intrathoracic pressure during thoracotomy , we believed that circulation should be depressed later or to a lesser extent in patients with an intraoperative pneumothorax . Yet , during thoracotomy , decrease in cardiac filling and output during tension pneumothorax in OLV obviously results primarily from the immovability of the mediastinum owing to mediastinal fixation and is at least as decisive as the contralateral intrathoracic pressure in closed-chest patients . In summary , a tension pneumothorax during one-lung ventilation and thoracotomy is a rare , but disastrous complication during the use of a DLT , which has not , to our knowledge , been reported previously . We recommend that tension pneumothorax be added to the list of complications and problems during OLV by the use of a DLT , especially in patients with structural lung diseases ."
],
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] |
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DerAnaesthesist.70460081.eng.abstr
|
DerAnaesthesist.70460081.eng.abstr
|
[
{
"id": "DerAnaesthesist.70460081.eng.abstr-passage-0",
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"text": [
"Thermoregulation and its impairment by anaesthesia and surgery has recently been brought back into focus by researchers and clinicians . All volatile and IV anaesthetics , opioids , as well as spinal and epidural anaesthesia increase the inter-threshold range of thermoregulation from 0.2 ° C to 4 ° C between vasodilation and vasoconstriction . Thermoregulatory vasoconstriction and shivering occurs in anaesthetized patients at lower core temperatures than in awake subjects . Following induction of general or spinal/epidural anaesthesia , core temperature decreases significantly due to internal redistribution of body heat from the core thermal compartment to peripheral tissues . About 1 h after induction of general anaesthesia and initial redistribution hypothermia , a real reduction in body heat occurs as heat loss exceeds metabolic heat production . Heat loss is further increased due to low operating room temperatures , evaporation from open body cavities , and cold IV fluids . Peripheral thermoregulatory vasoconstriction is triggered by core temperatures between 33 ° C and 35 ° C , and is able to slow heat loss . However , body heat content continues to decrease even though core temperatures remain nearly constant . During spinal or epidural anaesthesia thermoregulation remains intact in the unblocked body segments , leading to reduced real heat loss when compared to general anaesthesia ."
],
"offsets": [
[
0,
1412
]
]
}
] |
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DerAnaesthesist.70460091.eng.abstr
|
DerAnaesthesist.70460091.eng.abstr
|
[
{
"id": "DerAnaesthesist.70460091.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Methods : In February 1995 a questionnaire was sent out on perioperative management during neurosurgical operations performed in the sitting position to 136 centres and hospitals within the Federal Republic of Germany that perform neuroanaesthesia . The response rate was 61.02% . Besides the question of perioperative monitoring during neurosurgical operations in the sitting position , we asked about currently used positions for patients during the following neurosurgical operations : posterior fossa , craniospinal and posterior cervical surgery . Results : Of all centres , 32.9% use the sitting position only for posterior fossa and craniospinal surgery . For posterior cervical surgery the sitting and prone positions are favoured by 25.6% of all clinics . Nonspecific basic monitoring ( electrocardiogram , pulse oximetry , central venous pressure , invasive or noninvasive arterial pressure ) is an accepted standard in all clinics . Capnometry , as a specific monitor for venous air embolism , is used in all centres ( 100% ) . Precordial Doppler ultrasound ( US ) monitoring is used in 69.2% of all clinics ; 3.8% use transoesophageal Doppler US as a diagnostic method for venous air embolism . Discussion : The sitting position is the preferred position for posterior fossa and craniospinal surgery in neurosurgical patients in Germany . For posterior cervical surgery the German centres use both the sitting and prone positions . Alternative positions like the lateral or the \" park-bench \" positions are hardly ever used . The essential monitoring devices for neurosurgical operations in the sitting position , as recommended after the survey by the German Society for Anaesthesiology and Intensive Care Medicine ( DGAI ) in 1995 , are predominantly used . However , the use of Doppler US ( precordial or transoesophageal ) for the detection of venous air embolism and the preoperative diagnosis of a persistent foramen ovale is not yet widespread . Conclusions : To determine the effect of the recommendations by the DGAI on clinical practice , the survey will be repeated in 1997."
],
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[
0,
2097
]
]
}
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{
"id": "DerAnaesthesist.70460091.eng.abstr-s12-r14-t5.1-t6.1",
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},
{
"id": "DerAnaesthesist.70460091.eng.abstr-s12-r15-t3.1-t7.2",
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},
{
"id": "DerAnaesthesist.70460091.eng.abstr-s12-r16-t1.1-t6.1",
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"normalized": []
},
{
"id": "DerAnaesthesist.70460091.eng.abstr-s12-r17-t8.1-t6.1",
"type": "method_of",
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},
{
"id": "DerAnaesthesist.70460091.eng.abstr-s12-r18-t1.1-t6.1",
"type": "issue_in",
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},
{
"id": "DerAnaesthesist.70460091.eng.abstr-s12-r19-t6.1-t5.1",
"type": "associated_with",
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"normalized": []
},
{
"id": "DerAnaesthesist.70460091.eng.abstr-s12-r20-t3.1-t6.1",
"type": "method_of",
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"normalized": []
},
{
"id": "DerAnaesthesist.70460091.eng.abstr-s12-r21-t2.2-t8.1",
"type": "carries_out",
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},
{
"id": "DerAnaesthesist.70460091.eng.abstr-s12-r22-t1.1-t5.1",
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"normalized": []
},
{
"id": "DerAnaesthesist.70460091.eng.abstr-s12-r23-t2.2-t5.1",
"type": "method_of",
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},
{
"id": "DerAnaesthesist.70460091.eng.abstr-s13-r2-t6.1-t4.2",
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},
{
"id": "DerAnaesthesist.70460091.eng.abstr-s13-r3-t3.1-t4.1",
"type": "associated_with",
"arg1_id": "DerAnaesthesist.70460091.eng.abstr-s13-t3",
"arg2_id": "DerAnaesthesist.70460091.eng.abstr-s13-t4",
"normalized": []
},
{
"id": "DerAnaesthesist.70460091.eng.abstr-s13-r4-t3.1-t4.2",
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"arg1_id": "DerAnaesthesist.70460091.eng.abstr-s13-t3",
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"normalized": []
},
{
"id": "DerAnaesthesist.70460091.eng.abstr-s13-r5-t4.1-t3.1",
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},
{
"id": "DerAnaesthesist.70460091.eng.abstr-s13-r6-t1.1-t3.1",
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},
{
"id": "DerAnaesthesist.70460091.eng.abstr-s13-r7-t4.1-t1.1",
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},
{
"id": "DerAnaesthesist.70460091.eng.abstr-s13-r8-t4.2-t6.1",
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},
{
"id": "DerAnaesthesist.70460091.eng.abstr-s13-r9-t1.1-t4.2",
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"arg2_id": "DerAnaesthesist.70460091.eng.abstr-s13-t4",
"normalized": []
},
{
"id": "DerAnaesthesist.70460091.eng.abstr-s13-r10-t6.1-t3.1",
"type": "location_of",
"arg1_id": "DerAnaesthesist.70460091.eng.abstr-s13-t6",
"arg2_id": "DerAnaesthesist.70460091.eng.abstr-s13-t3",
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},
{
"id": "DerAnaesthesist.70460091.eng.abstr-s13-r11-t4.2-t3.1",
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"arg2_id": "DerAnaesthesist.70460091.eng.abstr-s13-t3",
"normalized": []
}
] |
DerAnaesthesist.70460096.eng.abstr
|
DerAnaesthesist.70460096.eng.abstr
|
[
{
"id": "DerAnaesthesist.70460096.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Mivacurium has a short duration of action because it is rapidly hydrolysed by plasma cholinesterase . There is ongoing controversy concerning the antagonism of mivacurium-induced neuromuscular block , firstly because of its short spontaneous recovery time , and secondly because the metabolism of mivacurium may be inhibited by anticholinesterases . We therefore compared neostigmine and edrophonium reversal of deep and moderate mivacurium-induced blocks ."
],
"offsets": [
[
0,
457
]
]
}
] |
[
{
"id": "DerAnaesthesist.70460096.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"Mivacurium"
],
"offsets": [
[
0,
10
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0066621"
}
]
},
{
"id": "DerAnaesthesist.70460096.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"plasma"
],
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[
78,
84
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0032105"
}
]
},
{
"id": "DerAnaesthesist.70460096.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"cholinesterase"
],
"offsets": [
[
85,
99
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0008429"
}
]
},
{
"id": "DerAnaesthesist.70460096.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"time"
],
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[
251,
255
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0040223"
}
]
},
{
"id": "DerAnaesthesist.70460096.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"metabolism"
],
"offsets": [
[
283,
293
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0025519"
},
{
"db_name": "UMLS",
"db_id": "C0025520"
}
]
},
{
"id": "DerAnaesthesist.70460096.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"mivacurium"
],
"offsets": [
[
297,
307
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0066621"
}
]
},
{
"id": "DerAnaesthesist.70460096.eng.abstr-s2-t4",
"type": "umlsterm",
"text": [
"anticholinesterases"
],
"offsets": [
[
328,
347
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0008425"
}
]
},
{
"id": "DerAnaesthesist.70460096.eng.abstr-s2-t5",
"type": "umlsterm",
"text": [
"neuromuscular block"
],
"offsets": [
[
179,
198
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0235062"
}
]
},
{
"id": "DerAnaesthesist.70460096.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"neostigmine"
],
"offsets": [
[
372,
383
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0027679"
}
]
},
{
"id": "DerAnaesthesist.70460096.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"edrophonium"
],
"offsets": [
[
388,
399
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0013615"
}
]
}
] |
[] |
[] |
[
{
"id": "DerAnaesthesist.70460096.eng.abstr-s1-r1-t3.1-t1.1",
"type": "interacts_with",
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},
{
"id": "DerAnaesthesist.70460096.eng.abstr-s1-r2-t1.1-t3.1",
"type": "consists_of",
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},
{
"id": "DerAnaesthesist.70460096.eng.abstr-s1-r3-t1.1-t3.1",
"type": "interacts_with",
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},
{
"id": "DerAnaesthesist.70460096.eng.abstr-s2-r1-t5.1-t2.2",
"type": "uses",
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"normalized": []
},
{
"id": "DerAnaesthesist.70460096.eng.abstr-s2-r2-t2.1-t1.1",
"type": "conceptual_part_of",
"arg1_id": "DerAnaesthesist.70460096.eng.abstr-s3-t2",
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"normalized": []
},
{
"id": "DerAnaesthesist.70460096.eng.abstr-s2-r3-t3.1-t2.2",
"type": "interacts_with",
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},
{
"id": "DerAnaesthesist.70460096.eng.abstr-s2-r4-t2.2-t3.1",
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"normalized": []
},
{
"id": "DerAnaesthesist.70460096.eng.abstr-s2-r5-t5.1-t3.1",
"type": "uses",
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"arg2_id": "DerAnaesthesist.70460096.eng.abstr-s2-t3",
"normalized": []
},
{
"id": "DerAnaesthesist.70460096.eng.abstr-s2-r6-t1.1-t2.1",
"type": "conceptual_part_of",
"arg1_id": "DerAnaesthesist.70460096.eng.abstr-s3-t1",
"arg2_id": "DerAnaesthesist.70460096.eng.abstr-s3-t2",
"normalized": []
},
{
"id": "DerAnaesthesist.70460096.eng.abstr-s2-r7-t2.2-t2.1",
"type": "affects",
"arg1_id": "DerAnaesthesist.70460096.eng.abstr-s2-t2",
"arg2_id": "DerAnaesthesist.70460096.eng.abstr-s3-t2",
"normalized": []
},
{
"id": "DerAnaesthesist.70460096.eng.abstr-s2-r8-t5.1-t2.1",
"type": "measures",
"arg1_id": "DerAnaesthesist.70460096.eng.abstr-s2-t5",
"arg2_id": "DerAnaesthesist.70460096.eng.abstr-s3-t2",
"normalized": []
},
{
"id": "DerAnaesthesist.70460096.eng.abstr-s2-r9-t3.1-t2.1",
"type": "affects",
"arg1_id": "DerAnaesthesist.70460096.eng.abstr-s2-t3",
"arg2_id": "DerAnaesthesist.70460096.eng.abstr-s3-t2",
"normalized": []
},
{
"id": "DerAnaesthesist.70460096.eng.abstr-s2-r10-t5.1-t2.2",
"type": "measures",
"arg1_id": "DerAnaesthesist.70460096.eng.abstr-s2-t5",
"arg2_id": "DerAnaesthesist.70460096.eng.abstr-s2-t2",
"normalized": []
},
{
"id": "DerAnaesthesist.70460096.eng.abstr-s2-r11-t5.1-t3.1",
"type": "measures",
"arg1_id": "DerAnaesthesist.70460096.eng.abstr-s2-t5",
"arg2_id": "DerAnaesthesist.70460096.eng.abstr-s2-t3",
"normalized": []
},
{
"id": "DerAnaesthesist.70460096.eng.abstr-s2-r12-t5.1-t2.1",
"type": "affects",
"arg1_id": "DerAnaesthesist.70460096.eng.abstr-s2-t5",
"arg2_id": "DerAnaesthesist.70460096.eng.abstr-s3-t2",
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},
{
"id": "DerAnaesthesist.70460096.eng.abstr-s2-r13-t5.1-t1.1",
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},
{
"id": "DerAnaesthesist.70460096.eng.abstr-s3-r1-t1.1-t2.1",
"type": "interacts_with",
"arg1_id": "DerAnaesthesist.70460096.eng.abstr-s3-t1",
"arg2_id": "DerAnaesthesist.70460096.eng.abstr-s3-t2",
"normalized": []
},
{
"id": "DerAnaesthesist.70460096.eng.abstr-s3-r2-t2.1-t1.1",
"type": "interacts_with",
"arg1_id": "DerAnaesthesist.70460096.eng.abstr-s3-t2",
"arg2_id": "DerAnaesthesist.70460096.eng.abstr-s3-t1",
"normalized": []
}
] |
DerAnaesthesist.70460101.eng.abstr
|
DerAnaesthesist.70460101.eng.abstr
|
[
{
"id": "DerAnaesthesist.70460101.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Intraoperative autotransfusion ( MAT ) , preoperative autologous blood donation , and preoperative normovolaemic haemodilution are three different methods to avoid homologous blood transfusion during surgical procedures . The controversial use of MAT via cell saver in tumour surgery as well as contamination of the operative field with urine illustrate the particular difficulties of autologous blood transfusion in connection with radical prostatectomy . We investigated changes in the osmotic resistance of the retransfused red blood cells ( RBC ) , bacterial contamination , changes in coagulation parameters , and the presence of tumour cells ."
],
"offsets": [
[
0,
649
]
]
}
] |
[
{
"id": "DerAnaesthesist.70460101.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"autotransfusion"
],
"offsets": [
[
15,
30
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0005842"
}
]
},
{
"id": "DerAnaesthesist.70460101.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"MAT"
],
"offsets": [
[
33,
36
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0066317"
}
]
},
{
"id": "DerAnaesthesist.70460101.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"blood"
],
"offsets": [
[
65,
70
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0005767"
},
{
"db_name": "UMLS",
"db_id": "C0005768"
},
{
"db_name": "UMLS",
"db_id": "C0005835"
}
]
},
{
"id": "DerAnaesthesist.70460101.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"haemodilution"
],
"offsets": [
[
113,
126
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0019009"
}
]
},
{
"id": "DerAnaesthesist.70460101.eng.abstr-s1-t5",
"type": "umlsterm",
"text": [
"methods"
],
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[
147,
154
]
],
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{
"db_name": "UMLS",
"db_id": "C0025663"
},
{
"db_name": "UMLS",
"db_id": "C0025664"
}
]
},
{
"id": "DerAnaesthesist.70460101.eng.abstr-s1-t6",
"type": "umlsterm",
"text": [
"blood"
],
"offsets": [
[
175,
180
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0005767"
},
{
"db_name": "UMLS",
"db_id": "C0005768"
},
{
"db_name": "UMLS",
"db_id": "C0005835"
}
]
},
{
"id": "DerAnaesthesist.70460101.eng.abstr-s1-t7",
"type": "umlsterm",
"text": [
"surgical"
],
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[
200,
208
]
],
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"db_id": "C0038895"
}
]
},
{
"id": "DerAnaesthesist.70460101.eng.abstr-s1-t8",
"type": "umlsterm",
"text": [
"procedures"
],
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209,
219
]
],
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"db_name": "UMLS",
"db_id": "C0184661"
},
{
"db_name": "UMLS",
"db_id": "C0025664"
}
]
},
{
"id": "DerAnaesthesist.70460101.eng.abstr-s1-t9",
"type": "umlsterm",
"text": [
"blood donation"
],
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[
65,
79
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0005794"
}
]
},
{
"id": "DerAnaesthesist.70460101.eng.abstr-s1-t10",
"type": "umlsterm",
"text": [
"blood transfusion"
],
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[
175,
192
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0005841"
}
]
},
{
"id": "DerAnaesthesist.70460101.eng.abstr-s1-t11",
"type": "umlsterm",
"text": [
"surgical procedures"
],
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[
200,
219
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0543467"
}
]
},
{
"id": "DerAnaesthesist.70460101.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"use"
],
"offsets": [
[
240,
243
]
],
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},
{
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},
{
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{
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},
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},
{
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},
{
"id": "DerAnaesthesist.70460101.eng.abstr-s2-r37-t8.1-t2.1",
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{
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},
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{
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},
{
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},
{
"id": "DerAnaesthesist.70460101.eng.abstr-s2-r43-t2.1-t6.2",
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},
{
"id": "DerAnaesthesist.70460101.eng.abstr-s2-r44-t9.1-t5.1",
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},
{
"id": "DerAnaesthesist.70460101.eng.abstr-s2-r45-t4.1-t7.2",
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},
{
"id": "DerAnaesthesist.70460101.eng.abstr-s2-r46-t10.1-t4.1",
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},
{
"id": "DerAnaesthesist.70460101.eng.abstr-s2-r47-t6.2-t1.1",
"type": "surrounds",
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},
{
"id": "DerAnaesthesist.70460101.eng.abstr-s2-r48-t8.1-t1.1",
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},
{
"id": "DerAnaesthesist.70460101.eng.abstr-s2-r49-t1.1-t10.1",
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},
{
"id": "DerAnaesthesist.70460101.eng.abstr-s2-r50-t6.2-t8.1",
"type": "location_of",
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},
{
"id": "DerAnaesthesist.70460101.eng.abstr-s2-r51-t1.1-t4.1",
"type": "affects",
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"arg2_id": "DerAnaesthesist.70460101.eng.abstr-s3-t4",
"normalized": []
},
{
"id": "DerAnaesthesist.70460101.eng.abstr-s3-r1-t1.1-t6.1",
"type": "location_of",
"arg1_id": "DerAnaesthesist.70460101.eng.abstr-s3-t1",
"arg2_id": "DerAnaesthesist.70460101.eng.abstr-s3-t6",
"normalized": []
},
{
"id": "DerAnaesthesist.70460101.eng.abstr-s3-r2-t4.1-t1.2",
"type": "analyzes",
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"arg2_id": "DerAnaesthesist.70460101.eng.abstr-s3-t1",
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},
{
"id": "DerAnaesthesist.70460101.eng.abstr-s3-r3-t1.2-t6.1",
"type": "causes",
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},
{
"id": "DerAnaesthesist.70460101.eng.abstr-s3-r4-t1.1-t7.1",
"type": "surrounds",
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"arg2_id": "DerAnaesthesist.70460101.eng.abstr-s3-t7",
"normalized": []
},
{
"id": "DerAnaesthesist.70460101.eng.abstr-s3-r5-t1.1-t2.1",
"type": "surrounds",
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},
{
"id": "DerAnaesthesist.70460101.eng.abstr-s3-r6-t4.1-t6.1",
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},
{
"id": "DerAnaesthesist.70460101.eng.abstr-s3-r7-t6.1-t1.1",
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},
{
"id": "DerAnaesthesist.70460101.eng.abstr-s3-r8-t1.1-t8.1",
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},
{
"id": "DerAnaesthesist.70460101.eng.abstr-s3-r10-t1.1-t3.1",
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},
{
"id": "DerAnaesthesist.70460101.eng.abstr-s3-r11-t6.1-t4.1",
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},
{
"id": "DerAnaesthesist.70460101.eng.abstr-s3-r13-t6.1-t1.2",
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},
{
"id": "DerAnaesthesist.70460101.eng.abstr-s3-r14-t1.1-t9.1",
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"arg2_id": "DerAnaesthesist.70460101.eng.abstr-s3-t9",
"normalized": []
}
] |
DerAnaesthesist.70460108.eng.abstr
|
DerAnaesthesist.70460108.eng.abstr
|
[
{
"id": "DerAnaesthesist.70460108.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The reliability of continuous fibreoptic oximetry in cerebral venous blood and its correlation with intracranial and cerebral perfusion pressures ( pressure-volume curve ) were examined in an experimental porcine study ."
],
"offsets": [
[
0,
220
]
]
}
] |
[
{
"id": "DerAnaesthesist.70460108.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"oximetry"
],
"offsets": [
[
41,
49
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0030021"
}
]
},
{
"id": "DerAnaesthesist.70460108.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"blood"
],
"offsets": [
[
69,
74
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0005767"
},
{
"db_name": "UMLS",
"db_id": "C0005768"
},
{
"db_name": "UMLS",
"db_id": "C0005835"
}
]
},
{
"id": "DerAnaesthesist.70460108.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"perfusion"
],
"offsets": [
[
126,
135
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0031001"
}
]
},
{
"id": "DerAnaesthesist.70460108.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"pressures"
],
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[
136,
145
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0033095"
}
]
},
{
"id": "DerAnaesthesist.70460108.eng.abstr-s1-t5",
"type": "umlsterm",
"text": [
"pressure-volume"
],
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[
148,
163
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0033095"
}
]
},
{
"id": "DerAnaesthesist.70460108.eng.abstr-s1-t6",
"type": "umlsterm",
"text": [
"porcine"
],
"offsets": [
[
205,
212
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0039005"
}
]
}
] |
[] |
[] |
[
{
"id": "DerAnaesthesist.70460108.eng.abstr-s1-r1-t4.1-t3.1",
"type": "conceptual_part_of",
"arg1_id": "DerAnaesthesist.70460108.eng.abstr-s1-t4",
"arg2_id": "DerAnaesthesist.70460108.eng.abstr-s1-t3",
"normalized": []
},
{
"id": "DerAnaesthesist.70460108.eng.abstr-s1-r2-t1.1-t2.2",
"type": "analyzes",
"arg1_id": "DerAnaesthesist.70460108.eng.abstr-s1-t1",
"arg2_id": "DerAnaesthesist.70460108.eng.abstr-s1-t2",
"normalized": []
},
{
"id": "DerAnaesthesist.70460108.eng.abstr-s1-r4-t1.1-t3.1",
"type": "precedes",
"arg1_id": "DerAnaesthesist.70460108.eng.abstr-s1-t1",
"arg2_id": "DerAnaesthesist.70460108.eng.abstr-s1-t3",
"normalized": []
},
{
"id": "DerAnaesthesist.70460108.eng.abstr-s1-r5-t1.1-t4.1",
"type": "measures",
"arg1_id": "DerAnaesthesist.70460108.eng.abstr-s1-t1",
"arg2_id": "DerAnaesthesist.70460108.eng.abstr-s1-t4",
"normalized": []
},
{
"id": "DerAnaesthesist.70460108.eng.abstr-s1-r6-t2.1-t1.1",
"type": "location_of",
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"arg2_id": "DerAnaesthesist.70460108.eng.abstr-s1-t1",
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},
{
"id": "DerAnaesthesist.70460108.eng.abstr-s1-r7-t2.1-t3.1",
"type": "location_of",
"arg1_id": "DerAnaesthesist.70460108.eng.abstr-s1-t2",
"arg2_id": "DerAnaesthesist.70460108.eng.abstr-s1-t3",
"normalized": []
},
{
"id": "DerAnaesthesist.70460108.eng.abstr-s1-r8-t1.1-t5.1",
"type": "measures",
"arg1_id": "DerAnaesthesist.70460108.eng.abstr-s1-t1",
"arg2_id": "DerAnaesthesist.70460108.eng.abstr-s1-t5",
"normalized": []
},
{
"id": "DerAnaesthesist.70460108.eng.abstr-s1-r9-t2.1-t6.1",
"type": "part_of",
"arg1_id": "DerAnaesthesist.70460108.eng.abstr-s1-t2",
"arg2_id": "DerAnaesthesist.70460108.eng.abstr-s1-t6",
"normalized": []
},
{
"id": "DerAnaesthesist.70460108.eng.abstr-s1-r10-t5.1-t3.1",
"type": "conceptual_part_of",
"arg1_id": "DerAnaesthesist.70460108.eng.abstr-s1-t5",
"arg2_id": "DerAnaesthesist.70460108.eng.abstr-s1-t3",
"normalized": []
}
] |
DerAnaesthesist.70460114.eng.abstr
|
DerAnaesthesist.70460114.eng.abstr
|
[
{
"id": "DerAnaesthesist.70460114.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Major incidents are high-profile events where many lives are at stake . The response of the health-care-related agencies has to be well-planned and co-ordinated , thus retaining the public's confidence in the emergency services whilst efficiently responding to those in need . The communication between supervising officers such as medical incident officer ( MIO ) and ambulance incident officer ( AIO ) with the ambulance personnel is vital for the proper employment of doctors and ambulance teams at the incident scene . In Germany the experience gained at such events has not yet been collected into a single coherent and comprehensive analysis . This study investigates the delivery of ambulance vehicles and personnel at major incidents . Was appropriate emergency treatment and transport for each seriously injured patient possible ? Were the communication structures between the supervising officers and the ambulance teams sufficient to provide effective co-ordination and utilisation of the teams at the scene ?"
],
"offsets": [
[
0,
1020
]
]
}
] |
[
{
"id": "DerAnaesthesist.70460114.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"lives"
],
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[
51,
56
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0376558"
}
]
},
{
"id": "DerAnaesthesist.70460114.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"public's"
],
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[
182,
190
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0605770"
}
]
},
{
"id": "DerAnaesthesist.70460114.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"emergency"
],
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[
209,
218
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0013956"
}
]
},
{
"id": "DerAnaesthesist.70460114.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"need"
],
"offsets": [
[
270,
274
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0027552"
}
]
},
{
"id": "DerAnaesthesist.70460114.eng.abstr-s2-t4",
"type": "umlsterm",
"text": [
"emergency services"
],
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[
209,
227
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0700036"
}
]
},
{
"id": "DerAnaesthesist.70460114.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"communication"
],
"offsets": [
[
281,
294
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0009452"
}
]
},
{
"id": "DerAnaesthesist.70460114.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"ambulance"
],
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[
369,
378
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0002422"
}
]
},
{
"id": "DerAnaesthesist.70460114.eng.abstr-s3-t3",
"type": "umlsterm",
"text": [
"ambulance"
],
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[
413,
422
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0002422"
}
]
},
{
"id": "DerAnaesthesist.70460114.eng.abstr-s3-t4",
"type": "umlsterm",
"text": [
"personnel"
],
"offsets": [
[
423,
432
]
],
"normalized": [
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[] |
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DerAnaesthesist.70460121.eng.abstr
|
DerAnaesthesist.70460121.eng.abstr
|
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],
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416
]
]
}
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] |
[] |
[] |
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] |
DerAnaesthesist.70460126.eng.abstr
|
DerAnaesthesist.70460126.eng.abstr
|
[
{
"id": "DerAnaesthesist.70460126.eng.abstr-passage-0",
"type": "abstract",
"text": [
"\" Stay and play , \" especially in emergency patients with unstable vital functions , offers definite advantages compared to \" scoop and run \" policies . Typical medical and tactical aspects can be identified to judge the amount of diagnostic and therapeutic measures necessary at the site and during transport . Scoop and run seems to be appropriate only rarely in a area with an emergency medical system in the German style ."
],
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0,
426
]
]
}
] |
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"id": "DerAnaesthesist.70460126.eng.abstr-s3-t1",
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"emergency"
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]
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{
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] |
[] |
[] |
[
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"type": "uses",
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},
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"id": "DerAnaesthesist.70460126.eng.abstr-s2-r1-t3.1-t1.1",
"type": "conceptual_part_of",
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DerAnaesthesist.70460133.eng.abstr
|
DerAnaesthesist.70460133.eng.abstr
|
[
{
"id": "DerAnaesthesist.70460133.eng.abstr-passage-0",
"type": "abstract",
"text": [
"In a recently published German multicenter study , 25% of the patients with witnessed cardiac arrest outside the hospital were resuscitated successfully and discharged from the hospital . Approximately 100,000 people suffer a fatal cardiac arrest in Germany anually , which is approximately tenfold the number of deaths from motor vehicle accidents . Cardiopulmonary resuscitation ( CPR ) performed by bystanders is an important part of the chain of survival to minimize the time interval without artificial circulation and ventilation in a cardiac arrest victim . This is especially important in areas with long response times of the emergency medical service ( EMS ) . Early examples of ventilation have been described throughout history . References to mouth-to-mouth ventilation ( MTMV ) are found in the Bible , in a description of the resuscitation of a coal miner in 1744 , and in an experiment in 1796 demonstrating that exhaled gas was safe for breathing . In 1954 , Elam and colleagues described artificial respiration with the exhaled gas of a rescuer using a mouth-to-mask ventilation method . The modern CPR era started with the combination of MTMV and chest compressions 35 years ago . However , the value of MTMV is currently under discussion because of a widespread fear of transmission of infectious diseases . Health-care professionals have stated in several studies that they may withhold MTMV when confronted with a cardiac arrest in a stranger . Although an infection with Mycobacterium tuberculosis is more likely than one with HIV via MTMV , the fear of the public is understandable . An expert committee of the American Heart Association stated that MTMV may be omitted in the initial phase of cardiac arrest , and considered recommending chest compressions only if the EMS will arrive rapidly . In paralyzed volunteers , however , ventilation induced by chest compressions was not able to provide sufficient gas exchange , especially when the airway was not protected . Laboratory investigations studying ventilation during CPR showed controlversial results ; in one animal model of cardiac arrest with muscle paralysis , chest compressions were not sufficient for adequate gas exchange , but active compression-decompression CPR achieved reasonable ventilation . Animal models that prevented gasping during cardiac arrest required ventilation during CPR , whereas gasping animals seemed to be satisfactorily ventilated with chest compressions alone . The question whether spontaneous gasping after cardiac arrest in humans may be sufficient for oxygenation and carbon dioxide elimination is debatable , and remains unanswered at this time . When cardiac arrest is monitored , frequent coughing by the patient may maintain artificial ventilation and circulation for 30 s. The strategy to compress the thorax first and then maintain the airway and perform ventilation may only have an advantage for the first 30 s of CPR . Therefore , MTMV remains the therapy of choice to ventilate the victim of cardiac arrest . If a rescuer chooses to not perform MTMV , at least chest compressions should be administered . During ventilation with an unprotected airway , tidal volumes of 0.5 l instead 0.8-1.2 l may have an advantage . This strategy would decrease the inspiratory flow rate and , therefore , peak airway inflation pressure , which is associated with stomach inflation . Animal models indicate that lower esophageal sphincter pressure may decrease rapidly to 5 cm H2O during cardiac arrest , which may further increase the importance of a low peak airway pressure during ventilation with an unprotected airway . Gastric inflation may cause , besides regurgitation , aspiration , and pneumonia , an increased intragastric pressure , which may push up the diaphragm , decrease lung compliance , and induce a vicious circle of hypoventilation and stomach inflation . The value of cricoid pressure during ventilation with an unprotected airway has to be addressed ."
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[
0,
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]
]
}
] |
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"id": "DerAnaesthesist.70460133.eng.abstr-s1-t5",
"type": "umlsterm",
"text": [
"cardiac arrest"
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"text": [
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"id": "DerAnaesthesist.70460133.eng.abstr-s2-t6",
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] |
[] |
[] |
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DerAnaesthesist.70460186.eng.abstr
|
DerAnaesthesist.70460186.eng.abstr
|
[
{
"id": "DerAnaesthesist.70460186.eng.abstr-passage-0",
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"text": [
"Study objective : Ketoprofen exerts its clinical effect by inhibition of prostaglandin synthesis , but also acts as an NMDA-receptor antagonist by means of the kynurenic acid . Based on ketoprofen's supposed central mechanism of analgesia , we expected a pre-emptive effect , which was assessed by the present study ."
],
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[
0,
317
]
]
}
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6,
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"inhibition"
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59,
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73,
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133,
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170,
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160,
174
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"id": "DerAnaesthesist.70460186.eng.abstr-s2-t1",
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186,
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229,
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{
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] |
[] |
[] |
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] |
DerAnaesthesist.70460191.eng.abstr
|
DerAnaesthesist.70460191.eng.abstr
|
[
{
"id": "DerAnaesthesist.70460191.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Introduction : Almost all patients treated with opioids suffer from constipation . Numerous laxatives are used to overcome the problem , but none has yet been found to yield favourable results in all patients . Several studies have attempted to reverse opioid-induced constipation by the use of oral naloxone . Experiments carried out in rats showed that morphine-induced constipation is reduced by oral naloxone without impairment of antinociception [ 4 ] . However , evaluation of clinical studies reveals that there is uncertainty about the dosage regimen ( the daily dose of naloxone ranged from 0.5% to about 60% that of morphine ) and a lack of larger numbers of patients studied ."
],
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[
0,
687
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] |
[] |
[] |
[
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] |
DerAnaesthesist.70460195.eng.abstr
|
DerAnaesthesist.70460195.eng.abstr
|
[
{
"id": "DerAnaesthesist.70460195.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The objective of the study was to investigate the clinical effectiveness of increasing the dosage of prilocaine for a combined 3-in-1/sciatic nerve block from 500 to 650 mg ( open study with 29 patients compared with 30 patients from a former study ) and to validate these findings in a second stage ( randomised study comparing two groups of 30 patients each ) . Not only was clinical effectiveness improved by increasing the dose to 650 mg , but methaemoglobinaemia and toxicity were not relevant problems . With the higher dosage , development of the block was slightly faster ( onset and completion ) ; there were fewer unsatisfactory blocks ; and clinically relevant plasma levels of methaemoglobin did not occur ."
],
"offsets": [
[
0,
719
]
]
}
] |
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"prilocaine"
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101,
111
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}
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},
{
"id": "DerAnaesthesist.70460195.eng.abstr-s1-t3",
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"nerve"
],
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142,
147
]
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"open"
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"patients"
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220,
228
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"findings"
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273,
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"patients"
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},
{
"id": "DerAnaesthesist.70460195.eng.abstr-s1-t10",
"type": "umlsterm",
"text": [
"nerve block"
],
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[
142,
153
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{
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"db_id": "C0027741"
}
]
},
{
"id": "DerAnaesthesist.70460195.eng.abstr-s2-t1",
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"methaemoglobinaemia"
],
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}
]
},
{
"id": "DerAnaesthesist.70460195.eng.abstr-s2-t2",
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"toxicity"
],
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[
472,
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{
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}
]
},
{
"id": "DerAnaesthesist.70460195.eng.abstr-s3-t1",
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"text": [
"development"
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]
},
{
"id": "DerAnaesthesist.70460195.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"faster"
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},
{
"id": "DerAnaesthesist.70460195.eng.abstr-s3-t3",
"type": "umlsterm",
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"plasma"
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},
{
"id": "DerAnaesthesist.70460195.eng.abstr-s3-t4",
"type": "umlsterm",
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{
"id": "DerAnaesthesist.70460195.eng.abstr-s3-t5",
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"id": "DerAnaesthesist.70460195.eng.abstr-s3-t6",
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{
"db_name": "UMLS",
"db_id": "C0019046"
}
]
}
] |
[] |
[] |
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] |
DerAnaesthesist.70460201.eng.abstr
|
DerAnaesthesist.70460201.eng.abstr
|
[
{
"id": "DerAnaesthesist.70460201.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Closed-system anaesthesia provides the best prerequisites for optimal warming and humidification of anaesthetic gases . The PhysioFlex anaesthesia machine fascilitates quantitative closed-system anaesthesia . Furthermore , its design may improve the climatisation of the anaesthetic gases by revolving the system volume at 70 l/min , using a small soda-lime canister to allow optimal usage of the heat and moisture generated by CO2 absorption and by integrating all system components in thermally isolating housing . To determine the capacity of the PhysioFlex to climatise anaesthetic gases , we evaluated the heat and humidity profile at four characteristic places in the anaesthetic circuit under standardised conditions in a model ."
],
"offsets": [
[
0,
736
]
]
}
] |
[
{
"id": "DerAnaesthesist.70460201.eng.abstr-s1-t1",
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"text": [
"anaesthetic"
],
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[
100,
111
]
],
"normalized": [
{
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}
]
},
{
"id": "DerAnaesthesist.70460201.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"gases"
],
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[
112,
117
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0017110"
}
]
},
{
"id": "DerAnaesthesist.70460201.eng.abstr-s3-t1",
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"text": [
"anaesthetic"
],
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[
271,
282
]
],
"normalized": [
{
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}
]
},
{
"id": "DerAnaesthesist.70460201.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"gases"
],
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[
283,
288
]
],
"normalized": [
{
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}
]
},
{
"id": "DerAnaesthesist.70460201.eng.abstr-s3-t3",
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"text": [
"soda-lime"
],
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[
348,
357
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],
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{
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"db_id": "C0064990"
}
]
},
{
"id": "DerAnaesthesist.70460201.eng.abstr-s3-t4",
"type": "umlsterm",
"text": [
"heat"
],
"offsets": [
[
397,
401
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0018843"
},
{
"db_name": "UMLS",
"db_id": "C0018837"
}
]
},
{
"id": "DerAnaesthesist.70460201.eng.abstr-s3-t5",
"type": "umlsterm",
"text": [
"CO2"
],
"offsets": [
[
428,
431
]
],
"normalized": [
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"db_id": "C0007012"
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]
},
{
"id": "DerAnaesthesist.70460201.eng.abstr-s3-t6",
"type": "umlsterm",
"text": [
"absorption"
],
"offsets": [
[
432,
442
]
],
"normalized": [
{
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"db_id": "C0000854"
},
{
"db_name": "UMLS",
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}
]
},
{
"id": "DerAnaesthesist.70460201.eng.abstr-s3-t7",
"type": "umlsterm",
"text": [
"housing"
],
"offsets": [
[
507,
514
]
],
"normalized": [
{
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"db_id": "C0020056"
}
]
},
{
"id": "DerAnaesthesist.70460201.eng.abstr-s4-t1",
"type": "umlsterm",
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"anaesthetic"
],
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574,
585
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],
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{
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},
{
"id": "DerAnaesthesist.70460201.eng.abstr-s4-t2",
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"gases"
],
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586,
591
]
],
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},
{
"id": "DerAnaesthesist.70460201.eng.abstr-s4-t3",
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],
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611,
615
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},
{
"id": "DerAnaesthesist.70460201.eng.abstr-s4-t4",
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"humidity"
],
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},
{
"id": "DerAnaesthesist.70460201.eng.abstr-s4-t5",
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],
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685
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0002932"
}
]
}
] |
[] |
[] |
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DerAnaesthesist.70460207.eng.abstr
|
DerAnaesthesist.70460207.eng.abstr
|
[
{
"id": "DerAnaesthesist.70460207.eng.abstr-passage-0",
"type": "abstract",
"text": [
"We report a rare case of spontaneously developing generalised gas gangrene with massive rhabdomyolysis after a cholecystectomy and drainage of a hepatic abscess . On preoperative physical examination the patient appeared severely ill and was icteric and oliguric . Laboratory evaluation showed signs of systemic inflammation , elevated lactate levels , evidence of disseminated intravascular coagulation ( DIC ) , and increased levels of serum creatine kinase ( CK ) activity . Abdominal ultrasound and endoscopic retrograde cholangiography showed a gallbladder perforation and a hepatic abscess . Cholecystectomy and drainage of the abscess was performed immediately and without technical problems . After postoperative admission to the intensive care unit , the patient showed evidence of generalised myonecrosis with subcutaneous gas formation and acute renal failure . Initially , there were few other signs of systemic toxicity ; the patient was not hypotensive and the pulmonary gas exchange was normal . Within hours diffuse swelling of his right leg developed with cutaneous gangrene and a compartment syndrome . After fasciectomy and extensive surgical debridement , uncontrollable bleeding due to DIC developed from the fasciectomy site , which finally required exarticulation of the leg at the hip joint . At this point , multiple organ failure including severe adult respiratory distress syndrome was present . Two days after cholecystectomy , the patient died from hypoxic cardiocirculatory failure . Clostridium perfringens was repeatedly isolated from the wounds . Besides gas gangrene , the differential diagnosis of such infections includes localised clostridial cellulitis , nonclostridial anaerobic cellulitis caused by mixed aerobes and anaerobes , and type I or type II necrotising fasciitis . Patients with systemic necrotising infections should be treated with broad-spectrum antimicrobial regimens ( penicillin G , 3rd generation cephalosporins , clindamycin , and aminoglycosides ) . An otherwise unexplained elevation of serum CK activity in the presence of acute cholecystitis may suggest haematologic spread of an aggressive myolytic agent and the beginning of myonecrosis . This should prompt immediate surgical exploration after establishing broad-spectrum antibiotic coverage . The role of hyperbaric oxygen treatment in this situation remains to be established . If hyperbaric oxygen is to be employed , it should neither delay surgical exploration nor jeopardise the patient with the hazards of an interhospital transport ."
],
"offsets": [
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0,
2556
]
]
}
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] |
DerAnaesthesist.70460211.eng.abstr
|
DerAnaesthesist.70460211.eng.abstr
|
[
{
"id": "DerAnaesthesist.70460211.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Generalized muscle weakness in critically ill patients can result in prolonged periods of artificial ventilation and longer stays in the intensive care unit . Both neuropathic ( critical illness polyneuropathy ) and myopathic ( critical illness myopathy ) abnormalities seem to play an important role for this prolonged weakness . This article reviews its complex differential diagnosis with special emphasis on the current understanding of the neuromuscular syndromes . An efficient diagnostic plan is necessary for the exclusion of other curable causes of prolonged muscle weakness even in the presence of polyneuromyopathic changes . Psychological support of the patient and prophylaxis of secondary complications of prolonged immobilization are crucial when specific therapy is not possible ."
],
"offsets": [
[
0,
796
]
]
}
] |
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12,
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"id": "DerAnaesthesist.70460211.eng.abstr-s1-t4",
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] |
[] |
[] |
[
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{
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DerAnaesthesist.70460220.eng.abstr
|
DerAnaesthesist.70460220.eng.abstr
|
[
{
"id": "DerAnaesthesist.70460220.eng.abstr-passage-0",
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"In a recent German multicenter study , 25% of the patients who suffered a witnessed cardiac arrest outside the hospital were resuscitated successfully and were discharged from the hospital . Approximately 100000 people suffer a fatal cardiac arrest in Germany annually , which is about ten times more than deaths resulting from motor vehicle accidents . New devices and techniques for cardiopulmonary resuscitation ( CPR ) have been developed in order to enhance the efficacy of chest compressions during CPR . The purpose of the present article is to review mechanisms of blood flow during CPR , to discuss CPR devices and techniques ( vest CPR , CPR with interposed abdominal compressions , active compression-decompression ( ACD ) CPR , phased chest and abdominal compression-decompression CPR , and to further evaluate results from subsequently published laboratory and clinical studies ."
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[] |
[] |
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DerAnaesthesist.70460261.eng.abstr
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DerAnaesthesist.70460261.eng.abstr
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"In more than 30 years of development of intensive care medicine ( ICM ) , our speciality has acquired moral and ethical standpoints , although not without public pressure and discussions . Special commissions dealing , e.g. , with brain death , terminal care , ethics of foregoing life-sustaining treatment in the critically ill , withholding or withdrawing mechanical ventilation , and other issues have meen formed in a number of medical societies . International consensus conferences have helped to clarify some of the issues . With increasing experience , a multitude of ethical problems have arisen in ICM that have to be dealt with , such as the issue of quality of life . What is an unworthy life ? Are we allowed to make judgments for our patients ? What is cost-effectiveness in ICM ? Other restrictions include bed and equipment shortages in the intensive care unit ( ICU ) , the necessity for triage - undisputed in catastrophe medicine - and how one should proceed in managing elective patients ? In situations of limited ICU bed availability , sicker patients will be admitted , sparing out patients who are less ill for observation and those with poor quality of life and poor prognosis . For the future , it will likely be necessary to define the patients who should be admitted to an ICU more than those who should not be admitted . An ICU treatment entitlement index would be directly proportional to the probability of successful outcome and the quality of the remaining life , and would be inversely related to costs for achieving success . The ICU outcome with survival , hospital mortality , and follow-up of ICU patients is considered . DNR ( do not resuscitate ) , the dying patient , terminal care , terminal weaning - DNT ( do not treat ) - active and passive euthanasia , living wills , quality of life , and cost-effectiveness for ICU patients are defined . Their application in the ICU will be discussed and problems pointed out . Outcome predictions using scores ( APACHE III , SAPS II , MPM ) have been developed based on previous experience , but should only be applied to patient groups and for quality assurance in ICUs . The most frequent and difficult problem in the ICU is the vegetative state , which requires an exact diagnosis . The differential diagnosis from other comatose states such as coma , brain death , and locked-in-syndrome is depicted . The ethics of interrupting life-sustaining treatment in critically ill patients have been worked out by a Task Force on Ethics of the Society of Critical Care Medicine ( 1990 ) . A consensus was found that the patient may judge to forego therapy ; ethically it is then appropriate to withhold or withdraw therapy . According to the consensus , withdrawing an already initiated treatment should not necessarily be regarded as more problematic than a decision not to initiate treatment . In my mind , however , there is a great difference between withdrawing or withholding , e.g. , ventilation . A dissentive opinion by some members of the Task Force stated that hydration and nutrition other than high-technology or parenteral nutrition are key components of patient care , and should not be equated with medical intervention . The ethical problems associated with active euthanasia ( physician-assisted suicide or death ) as practised in the Netherlands are also discussed . In most countries this practice seems unacceptable . From 30 years experience in ICM , there are many more ethical questions and case reports without clear solutions . Care decisions for single patients in unacceptable situations should be made after medical evaluation by the intensivist with the medical team and , if possible , by the patient and/or his or her surrogate . Legislation and solutions cannot be expected for single patients , but ethics committees could be helpful in decision-making ."
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] |
DerAnaesthesist.70460275.eng.abstr
|
DerAnaesthesist.70460275.eng.abstr
|
[
{
"id": "DerAnaesthesist.70460275.eng.abstr-passage-0",
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"text": [
"Objective : Thirty years ago , cardiopulmonary resuscitation ( CPR ) was primarily developed for otherwise healthy individuals who experienced sudden cardiac arrest . Today , CPR is widely viewed as an emergency procedure that can be attempted on any person who undergoes a cessation of cardiorespiratory function . Therefore , the appropriateness of CPR has been questioned as a matter of the outcome , the patient's preferences , and the cost . The objective of this article is to analyse ethical issues in prehospital resuscitation . Arguments : CPR is bound by moral considerations that surround the use of any medical treatment . According to Beauchamp and Childress , the hierarchy of justification in biomedical ethics consists of ethical theories , principles , rules , and particular judgements and actions . The decision to start CPR is based on the medical judgement that a person is suffering from circulatory arrest . The decision is justified by the moral rule that the victim of a cardiac arrest has the right to survive and to receive CPR . Moral rules are more specific to contexts and are based on ethical principles . The principle of beneficence means the provision of benefits for the promotion of welfare . Talking about beneficence in resuscitation means once again reporting stories of success , as many victims of pre- and in-hospital sudden death have been saved in the past . Nevertheless , resuscitative efforts still remain unsuccessful in the majority of cases , involving the principle of nonmaleficence . There is potential harm in CPR . Survivors may recover cardiac function , but sustain severe hypoxic brain damage , at worst surviving without awakening for months or years . In particular , post-traumatic CPR is associated with an extremely poor outcome , leading to the issue of futility . However , futility should be defined in a strict fashion , as there might be an individual chance of survival . The principle of respect for autonomy means the right of a patient to accept or reject medical treatment , which continues in emergency conditions and after the patient has lost consciousness . The time frame in CPR requires medical decision-making within seconds , and CPR is usually initiated without the patient's involvement . If the patient's wish's can be ascertained later on , life-sustaining therapies might be withdrawn at that time . Terminally ill but still competent patients should be encouraged to write a no-CPR document , which does not deny patients relief from severe symptoms , but might facilitate withholding resuscitative efforts at the scene . The principle of justice affects priorities in the allocation of health care resources . The decision made for a particular patient might delay or prevent emergency treatment in other patients who could receive greater benefit . Conclusions : The standard of care remains the prompt initiation of CPR . However , ethical principles such as beneficene , nonmaleficence , autonomy , and justice have to be applied in the unique setting of emergency medicine . Physicians have to consider the therapeutic efficacy of CPR , the potential risks , and the patient's preferences ."
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DerAnaesthesist.70460287.eng.abstr
|
DerAnaesthesist.70460287.eng.abstr
|
[
{
"id": "DerAnaesthesist.70460287.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Objectives : Due to its low solubility and negligible metabolism , desflurane is assumed to be especially suitable for application by low-flow anaesthetic techniques . The aim of this clinical investigation was the development of a standardised dosing scheme for low-flow and minimal-flow desflurane anaesthesia . Methods : One hundred six ASA status I-II patients were assigned to six groups according to the duration of the initial high-flow phase , fresh gas flow , and fresh-gas desflurane concentration . The median age , height , body weight , and constitution of the groups was comparable . After an initial high-flow phase using 4.4 l/min , the fresh gas flow was reduced to 0.5 l/min ( minimal-flow anaesthesia ) or 1.0 l/min ( low-flow anaesthesia ) . Inspired nitrous oxide concentrations were maintained at 60% to 70% . Using different standardised schemes of vaporizer settings , inspired desflurane concentrations were applied in the range from 3.4% to 8.7% , i.e. , between 1 and 1.5 MAC . Inspired and expired desflurane concentrations were measured continuously by the side-stream technique and recorded on-line . Venous blood samples were taken immediately prior to induction and 45 min after flow reduction for measurement of carboxyhaemoglobin ( COHb ) concentration ) . Results : In the 10- to 15-min initial phase during which a high fresh gas flow of 4.4 l/min was used , the inspired desflurane concentration reached values in the range of 90%-95% of the fresh gas concentration . In low-flow anaesthesia this concentration could be maintained without any alteration of the vaporizer setting , whereas in minimal-flow anaesthesia with flow reduction the fresh gas concentration had to be increased by 1% to 2% : The quotient calculated by division of the inspired desflurane concentration by its fresh gas concentration ( Q=CI/CF) ranges between 0.65 and 0.75 in minimal-flow and between 0.80 and 0.85 in low-flow anaesthesia . If use was made of the wide output range of the desflurane vaporizer , the inspired concentration could be increased rapidly by about 5% in 8 min , although the flow was kept constant at 0.5 l/min . Compared with its value prior to induction ( 2.13 +/- 1.05% ) , the COHb concentration decreased statistically significantly by about 0.7% during the 1st hour of minimal-flow anaesthesia ( 1.42 +/- 1.01% ) . In no case was a COHb concentration observed that exceeded threatening or even toxic values , although the soda lime was changed routinely only once a week . Conclusions : The pharmacokinetic properties of desflurane , resulting in especially low individual uptake , and the wide output range of the vaporizer facilitate the use of low-flow anaesthetic techniques in routine clinical practice . Even in minimal-flow anaesthesia , the duration of the initial high-flow phase can be shortened to min . If the flow is reduced to 1 l/min , the inspired desflurane concentration achieved in the initial high-flow phase can be maintained without any alteration of the vaporizer setting . In minimal-flow anaesthesia , however , with flow reduction to 0.5 l/min , the fresh gas concentration has to be increased to a value 1%-2% higher than the inspired nominal value . Due to the wide dialling range of the desflurane vaporizer , the amount of vapour delivered into the breathing system can be increased to about 110 ml/min even at a flow of 0.5 l/min . The large amount of agent that can be delivered into the system even under low-flow conditions , together with the very low individual uptake , results in a time-constant that is sufficiently short for the clinically required rapid increase in inspired desflurane concentrations . The short time-constant of low-flow desflurane anaesthesia improves the control of the anaesthetic concentration . If all measures are taken to safely avoid inadvertent drying out of the soda lime , there is no evidence that low-flow anaesthesia with desflurane is liable to increase the risk of accidental ca"
],
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[
0,
3997
]
]
}
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[] |
[] |
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] |
DerAnaesthesist.70460294.eng.abstr
|
DerAnaesthesist.70460294.eng.abstr
|
[
{
"id": "DerAnaesthesist.70460294.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The effect of aprotinin ( 2000000 IU as a bolus +500000 JU/h until the end of the operation ) on transfusion requirements and coagulation parameters in orthotopic liver transplantation ( study group : n=9; placebo group : n=9) was investigated in a randomised , double-blind study . Coagulation parameters were monitored intraoperatively using a mobile laboratory . In contrast to the published results , no effect on transfusion requirements could be demonstrated . However , aprotinin showed a positive effect on some coagulation parameters in the reperfusion phase . The mechanism appeared to be inhibition of the contact activation of the intrinsic system with less thrombin generation in the study group ."
],
"offsets": [
[
0,
710
]
]
}
] |
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],
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14,
23
]
],
"normalized": [
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}
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},
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"id": "DerAnaesthesist.70460294.eng.abstr-s1-t2",
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"text": [
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],
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91
]
],
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}
]
},
{
"id": "DerAnaesthesist.70460294.eng.abstr-s1-t3",
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],
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137
]
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}
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},
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"id": "DerAnaesthesist.70460294.eng.abstr-s1-t4",
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"text": [
"liver"
],
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"id": "DerAnaesthesist.70460294.eng.abstr-s1-t5",
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],
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184
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},
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"id": "DerAnaesthesist.70460294.eng.abstr-s1-t6",
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"id": "DerAnaesthesist.70460294.eng.abstr-s1-t7",
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{
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] |
[] |
[] |
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}
] |
DerAnaesthesist.70460303.eng.abstr
|
DerAnaesthesist.70460303.eng.abstr
|
[
{
"id": "DerAnaesthesist.70460303.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Impaired adrenal function during perioperative stress carries the risk of acute cortisol ( Cs ) deficiency ( Addisonian crisis ) , which may be critical without Cs supplementation . Thus , with evidence of dysfunction of the adrenal glands perioperative substitution is indicated . However , it is unclear whether unilateral adrenalectomy may attenuate the adrenocorticoid response . Glucocorticosteroids are potent agents with several well-known side effects . The purpose of the present study was to evaluate if routine Cs supplementation is justified and necessary in patients undergoing adrenalectomy during nephrectomy for renal-cell cancer ."
],
"offsets": [
[
0,
647
]
]
}
] |
[
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"function"
],
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17,
25
]
],
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]
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{
"id": "DerAnaesthesist.70460303.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"stress"
],
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[
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53
]
],
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{
"db_name": "UMLS",
"db_id": "C0038435"
}
]
},
{
"id": "DerAnaesthesist.70460303.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"risk"
],
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[
66,
70
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0035647"
}
]
},
{
"id": "DerAnaesthesist.70460303.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"cortisol"
],
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[
80,
88
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0020268"
}
]
},
{
"id": "DerAnaesthesist.70460303.eng.abstr-s1-t5",
"type": "umlsterm",
"text": [
"deficiency"
],
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[
96,
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]
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{
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"db_id": "C0011155"
}
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{
"id": "DerAnaesthesist.70460303.eng.abstr-s1-t6",
"type": "umlsterm",
"text": [
"supplementation"
],
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[
164,
179
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],
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"db_name": "UMLS",
"db_id": "C0242297"
}
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},
{
"id": "DerAnaesthesist.70460303.eng.abstr-s1-t7",
"type": "umlsterm",
"text": [
"risk of"
],
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[
66,
73
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},
{
"id": "DerAnaesthesist.70460303.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
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],
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[
206,
217
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},
{
"id": "DerAnaesthesist.70460303.eng.abstr-s2-t2",
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"text": [
"adrenal glands"
],
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[
225,
239
]
],
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"db_id": "C0001625"
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}
]
},
{
"id": "DerAnaesthesist.70460303.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"adrenalectomy"
],
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[
325,
338
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],
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"side effects"
],
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{
"id": "DerAnaesthesist.70460303.eng.abstr-s5-t1",
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"supplementation"
],
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525,
540
]
],
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{
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}
]
},
{
"id": "DerAnaesthesist.70460303.eng.abstr-s5-t2",
"type": "umlsterm",
"text": [
"patients"
],
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[
571,
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},
{
"id": "DerAnaesthesist.70460303.eng.abstr-s5-t3",
"type": "umlsterm",
"text": [
"adrenalectomy"
],
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591,
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]
},
{
"id": "DerAnaesthesist.70460303.eng.abstr-s5-t4",
"type": "umlsterm",
"text": [
"nephrectomy"
],
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[
612,
623
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"db_id": "C0027695"
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]
},
{
"id": "DerAnaesthesist.70460303.eng.abstr-s5-t5",
"type": "umlsterm",
"text": [
"renal-cell"
],
"offsets": [
[
628,
638
]
],
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"db_id": "C0007634"
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},
{
"id": "DerAnaesthesist.70460303.eng.abstr-s5-t6",
"type": "umlsterm",
"text": [
"cancer"
],
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[
639,
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]
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"normalized": [
{
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]
}
] |
[] |
[] |
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DerAnaesthesist.70460309.eng.abstr
|
DerAnaesthesist.70460309.eng.abstr
|
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"The concept of small-volume resuscitation , the rapid infusion of a small volume ( 4 ml/kg BW ) of hyperosmolar 7.2-7.5% saline solution for the initial therapy of severe hypovolemia and shock was advocated more than a decade ago . Numerous publications have established that hyperosmolar saline solution can restore arterial blood pressure , cardiac index and oxygen delivery as well as organ perfusion to pre-shock values . Most prehospital studies failed to yield conclusive results with respect to a reduction in overall mortality . A meta-analysis of preclinical studies from North and South America , however , has indicated an increase in survival rate by 5.1% following small-volume resuscitation when compared to standard of care . Moreover , small-volume resuscitation appears to be of specific impact in patients suffering from head injuries with increased ICP and in severest trauma requiring immediate surgical intervention ."
],
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[
0,
938
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}
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] |
[] |
[] |
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DerAnaesthesist.70460329.eng.abstr
|
DerAnaesthesist.70460329.eng.abstr
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] |
DerAnaesthesist.70460335.eng.abstr
|
DerAnaesthesist.70460335.eng.abstr
|
[
{
"id": "DerAnaesthesist.70460335.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Objectives : Due to its unique pharmacokinetics , the new esterase-metabolised opioid remifentanil results in rapid post-anaesthesia recovery . The aim of this clinical investigation was to compare recovery times after remifentanil anaesthesia in combination with hypnotic concentrations of either propofol or isoflurane . Dosages used in the study protocol were based on recommendations by the pharmaceutical manufacturer . Methods : Patients ( ASA status I-II ) scheduled for elective arthroscopy were included in this trial . Without premedication in the morning , anaesthesia was induced identically in both groups : remifentanil bolus ( 1 µg/kg), start of remifentanil-infusion ( 0.5 µg/kg/min), followed immediately by propofol ( ca. 2 mg/kg ) . For maintenance of anaesthesia remifentanil ( 0.25 µg/kg/min) was combined with either a propofol infusion of 0.1 mg/kg/min or 0.5 MAC isoflurane ( =0 . 6 vol . % ) in O2/air. Anaesthetic delivery was discontinued simultaneously with termination of surgery and recovery times were recorded . Results : A total of 40 patients were studied at random in two groups of 20 each with comparable demographic data and anaesthetic technique ( Tables 1 and 2 ) . In both groups emergence was very rapid . Recovery times were significantly shorter for remifentanil-isoflurane than for remifentanil-propofol ( Table 3 ) : spontaneous ventilation 5.1 vs 8.1 min ( P 0.05 ) , extubation 5.5 vs. 8.6 min ( P 0.02 ) , post-anaesthesia recovery score > =9 of 10 points 6.2 vs 11.3 min ( P 0.01 ) , and arrival at PACU 16.2 vs 19.2 min ( P 0.01 ) . Mild to moderate shivering was noted in 40% of all patients ( 9 cases following isoflurane , 7 following propofol ) . Conclusions : Using the manufacturer's recommended dosages , emergence after remifentanil anaesthesia is more rapid with 0.5 MAC isoflurane than with 0.1 mg/kg/min propofol . These results are most probably due to the different pharmacological properties of both co-anaesthetics , especially the applied dosages , and to different interactions with remifentanil . Present clinical experience suggests that a further dose reduction , especially for propofol , is possible . For both remifentanil groups emergence was remarkably rapid between return of consciousness and the awake state ( on-off phenomenon ) , which might contribute to post-anaesthesia safety ."
],
"offsets": [
[
0,
2361
]
]
}
] |
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207,
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]
},
{
"id": "DerAnaesthesist.70460335.eng.abstr-s2-t3",
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"remifentanil"
],
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219,
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{
"id": "DerAnaesthesist.70460335.eng.abstr-s2-t4",
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"hypnotic"
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264,
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"concentrations"
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"id": "DerAnaesthesist.70460335.eng.abstr-s2-t6",
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"text": [
"propofol"
],
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298,
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{
"id": "DerAnaesthesist.70460335.eng.abstr-s2-t7",
"type": "umlsterm",
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310,
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"db_id": "C0022180"
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"id": "DerAnaesthesist.70460335.eng.abstr-s2-t8",
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"id": "DerAnaesthesist.70460335.eng.abstr-s3-t1",
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] |
DerAnaesthesist.70460339.eng.abstr
|
DerAnaesthesist.70460339.eng.abstr
|
[
{
"id": "DerAnaesthesist.70460339.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Objective : Recent evidence suggests a possible role for Haeme oxygenase ( HO ) -derived carbon monoxide ( CO ) in the regulation of vascular tone through elevation of cyclic 3 ' -5 ' guanosine monophosphate ( cGMP ) . Previous work from our laboratory has shown that blockade of the HO pathway by tin-protoporphyrin-IX ( SnPP ) after resuscitation from haemorrhage leads to a specific and profound increase in portal resistance while neither systemic nor hepatic arterial resistance are affected . We therefore investigated the organ-specific expression pattern of the stress-inducible protein haeme oxygenase-1/heat shock protein 32 after haemorrhage and resuscitation ."
],
"offsets": [
[
0,
672
]
]
}
] |
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{
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9
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"id": "DerAnaesthesist.70460339.eng.abstr-s1-t2",
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"role"
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[
48,
52
]
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{
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}
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},
{
"id": "DerAnaesthesist.70460339.eng.abstr-s1-t3",
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"text": [
"oxygenase"
],
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[
63,
72
]
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{
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"db_id": "C0030065"
}
]
},
{
"id": "DerAnaesthesist.70460339.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"carbon"
],
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[
89,
95
]
],
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{
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"db_id": "C0007009"
}
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},
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"regulation"
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[
119,
129
]
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{
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}
]
},
{
"id": "DerAnaesthesist.70460339.eng.abstr-s1-t6",
"type": "umlsterm",
"text": [
"guanosine"
],
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[
184,
193
]
],
"normalized": [
{
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"db_id": "C0018330"
}
]
},
{
"id": "DerAnaesthesist.70460339.eng.abstr-s1-t7",
"type": "umlsterm",
"text": [
"cGMP"
],
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210,
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]
},
{
"id": "DerAnaesthesist.70460339.eng.abstr-s1-t8",
"type": "umlsterm",
"text": [
"carbon monoxide"
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[
89,
104
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{
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"db_id": "C0007018"
}
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},
{
"id": "DerAnaesthesist.70460339.eng.abstr-s1-t9",
"type": "umlsterm",
"text": [
"guanosine monophosphate"
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[
184,
207
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],
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{
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"db_id": "C0520462"
}
]
},
{
"id": "DerAnaesthesist.70460339.eng.abstr-s2-t1",
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"text": [
"work"
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[
228,
232
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{
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},
{
"id": "DerAnaesthesist.70460339.eng.abstr-s2-t2",
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242,
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{
"id": "DerAnaesthesist.70460339.eng.abstr-s2-t3",
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"resuscitation"
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335,
348
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},
{
"id": "DerAnaesthesist.70460339.eng.abstr-s2-t4",
"type": "umlsterm",
"text": [
"haemorrhage"
],
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354,
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{
"id": "DerAnaesthesist.70460339.eng.abstr-s3-t1",
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"protein"
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"id": "DerAnaesthesist.70460339.eng.abstr-s3-t2",
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},
{
"id": "DerAnaesthesist.70460339.eng.abstr-s3-t3",
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"id": "DerAnaesthesist.70460339.eng.abstr-s3-t4",
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}
] |
[] |
[] |
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},
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] |
DerAnaesthesist.70460385.eng.abstr
|
DerAnaesthesist.70460385.eng.abstr
|
[
{
"id": "DerAnaesthesist.70460385.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Mivacurium is a short-acting , nondepolarising muscle relaxant of the benzylisoquinoline type that undergoes rapid breakdown by plasma cholinesterase . After 2.5 times the ED95 ( 0.2 mg/kg ) , tracheal intubation can be accomplished within 2-3 min following injection . The ensuing DUR 25% ( i.e. , time from injection to 25% recovery of control twitch tension ) is three times as long as with succinylcholine . The principal side effects of mivacurium are facial flushing and a transient fall in blood pressure due to moderate histamine release following doses 3-4 times the ED95. In patients with end-stage liver or renal disease as well as those with atypical plasma cholinesterase , the duration of action of mivacurium is prolonged ."
],
"offsets": [
[
0,
738
]
]
}
] |
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0,
10
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},
{
"id": "DerAnaesthesist.70460385.eng.abstr-s1-t2",
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"muscle"
],
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47,
53
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],
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}
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},
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"id": "DerAnaesthesist.70460385.eng.abstr-s1-t3",
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"plasma"
],
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128,
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]
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},
{
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],
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"times"
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},
{
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"intubation"
],
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202,
212
]
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"db_id": "C0021925"
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"id": "DerAnaesthesist.70460385.eng.abstr-s3-t1",
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"DUR"
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282,
285
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"db_id": "C0206176"
}
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},
{
"id": "DerAnaesthesist.70460385.eng.abstr-s3-t2",
"type": "umlsterm",
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"time"
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}
]
},
{
"id": "DerAnaesthesist.70460385.eng.abstr-s3-t3",
"type": "umlsterm",
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"injection"
],
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309,
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"id": "DerAnaesthesist.70460385.eng.abstr-s3-t4",
"type": "umlsterm",
"text": [
"control"
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},
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"times"
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]
},
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"id": "DerAnaesthesist.70460385.eng.abstr-s3-t6",
"type": "umlsterm",
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"succinylcholine"
],
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"db_id": "C0038627"
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"id": "DerAnaesthesist.70460385.eng.abstr-s4-t1",
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},
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"id": "DerAnaesthesist.70460385.eng.abstr-s4-t2",
"type": "umlsterm",
"text": [
"transient"
],
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"id": "DerAnaesthesist.70460385.eng.abstr-s4-t4",
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"patients"
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{
"id": "DerAnaesthesist.70460385.eng.abstr-s4-t9",
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"text": [
"liver"
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"db_id": "C0022658"
}
]
}
] |
[] |
[] |
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"type": "interacts_with",
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{
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] |
DerAnaesthesist.70460389.eng.abstr
|
DerAnaesthesist.70460389.eng.abstr
|
[
{
"id": "DerAnaesthesist.70460389.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Background : We prospectively used the laryngeal mask airway ( LM ) in eye surgery to evaluate : 1 ) the limits of safe handling ; 2 ) the feasibility of its use in long operative procedures , and 3 ) whether patients with higher anaesthetic risk ( hypertension , asthma , children ) may profit from the LM . Methods : In 792 patients leak pressure , cuff volume , duration of anaesthesia , and complications were noted ; 33 were children under 10 years of age , 100 had hypertension or severe asthma . In 54 patients cuff volume was increased to measure its influence on leak pressure ; in 241 leak pressure was also measured at the end of the procedure ; in 31 cuff pressure was measured under standard conditions over time ; in 7 dead space was evaluated with the BANALYZER program ; and in 300 blind endotracheal suction was attempted through the LM . Results : Limits for the safe use of the LM were a leak pressure 12 cm H2O combined with insufficient spontaneous ventilation ( CO2et > 7 vol . % ; n=14), dislocation with gastric inflation ( n=2), and bronchial secretions ( n=1), as blind suctioning of the trachea through the LM was possible in only 1 out of 300 attempts . These limits could be recognised before the start of the operation in most cases . Laryngospasm or closure of the glottis ( n=36, 4.5% ) was treatable and did not necessitate abandoning the use of the LM . Mean leak pressure was 17.7 +/- 4.8 cm H2O, showing a comparable distribution in adults and in children and being improved mainly by position changes of the LM , but not by changes in cuff volume . No gas leak occurred when the individual peak inspiratory pressure was equal to or lower than the measured leak pressure except in children . Dead space was almost halved by the LM compared to a face mask ( 90 +/- 13 vs. 162 +/- 31 ml ; P 0.05 ) , allowing spontaneous breathing to be adequate even when manual assistance of ventilation was not possible ( n=14, 1.8% ) . In patients with sufficiently high leak pressures , the LM was safely used for long operations ( up to 240 min ) , as leak pressure did not change over time . When only a low leak pressure could be achieved , deep breaths could be delivered by prolongation of the inspiratory time , thereby preventing atelectasis if tidal volume was limited . Cuff pressure rose to about 100 cm H2O within 60 min and should be monitored . In children , air was aspirated intermittently out of the stomach in procedures longer than 30 min ; in adults , we monitored and buffered gastric contents where necessary . In patients at risk , the LM stimulates the circulation and bronchial reactivity less than an endotracheal tube . Children could be discharged earlier from the recovery room ( 0.45-1.5 h vs. > =2 h after neuromuscular relaxation and intubation ) . Conclusion : Limits for the use of the LM in eye surgery are delineated . Within these limits , the LM offers control over the airway comparable to that of an endotracheal tube with less stimulation . The LM has to be applied by an experienced user , and has advantages in eye surgery ."
],
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"id": "DerAnaesthesist.70460389.eng.abstr-s17-r7-t1.1-t2.2",
"type": "part_of",
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"arg2_id": "DerAnaesthesist.70460389.eng.abstr-s19-t2",
"normalized": []
},
{
"id": "DerAnaesthesist.70460389.eng.abstr-s17-r8-t2.3-t2.2",
"type": "causes",
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"arg2_id": "DerAnaesthesist.70460389.eng.abstr-s19-t2",
"normalized": []
},
{
"id": "DerAnaesthesist.70460389.eng.abstr-s17-r9-t2.3-t2.2",
"type": "issue_in",
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"arg2_id": "DerAnaesthesist.70460389.eng.abstr-s19-t2",
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},
{
"id": "DerAnaesthesist.70460389.eng.abstr-s17-r10-t2.2-t2.3",
"type": "affects",
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"arg2_id": "DerAnaesthesist.70460389.eng.abstr-s17-t2",
"normalized": []
},
{
"id": "DerAnaesthesist.70460389.eng.abstr-s17-r11-t1.1-t2.2",
"type": "issue_in",
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},
{
"id": "DerAnaesthesist.70460389.eng.abstr-s17-r12-t1.1-t3.2",
"type": "location_of",
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},
{
"id": "DerAnaesthesist.70460389.eng.abstr-s17-r13-t3.2-t2.2",
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},
{
"id": "DerAnaesthesist.70460389.eng.abstr-s19-r1-t1.2-t2.2",
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},
{
"id": "DerAnaesthesist.70460389.eng.abstr-s19-r2-t2.2-t1.2",
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},
{
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},
{
"id": "DerAnaesthesist.70460389.eng.abstr-s19-r6-t1.1-t2.2",
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},
{
"id": "DerAnaesthesist.70460389.eng.abstr-s19-r10-t2.2-t1.2",
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"normalized": []
}
] |
DerAnaesthesist.70460403.eng.abstr
|
DerAnaesthesist.70460403.eng.abstr
|
[
{
"id": "DerAnaesthesist.70460403.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The mucociliary escalator of the lung is an important protective transport system by means of which inhaled particles and microorganisms are removed from the tracheobronchial system . In general , it is assumed that anaesthetics inhibit mucociliary clearance [ 3 , 5 , 6 , 19 , 27 ] . In the present prospective study the effect of combination anaesthesia with isoflurane , fentanyl , vecuronium , and nitrous oxide-oxygen mixture on bronchial mucus transport velocity ( BTV ) was investigated ."
],
"offsets": [
[
0,
495
]
]
}
] |
[
{
"id": "DerAnaesthesist.70460403.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"escalator"
],
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[
16,
25
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0014829"
}
]
},
{
"id": "DerAnaesthesist.70460403.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"lung"
],
"offsets": [
[
33,
37
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0024109"
}
]
},
{
"id": "DerAnaesthesist.70460403.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"transport"
],
"offsets": [
[
65,
74
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0005528"
}
]
},
{
"id": "DerAnaesthesist.70460403.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"anaesthetics"
],
"offsets": [
[
216,
228
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0002932"
}
]
},
{
"id": "DerAnaesthesist.70460403.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"mucociliary clearance"
],
"offsets": [
[
237,
258
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0026687"
}
]
},
{
"id": "DerAnaesthesist.70460403.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"isoflurane"
],
"offsets": [
[
361,
371
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0022180"
}
]
},
{
"id": "DerAnaesthesist.70460403.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"fentanyl"
],
"offsets": [
[
374,
382
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0015846"
}
]
},
{
"id": "DerAnaesthesist.70460403.eng.abstr-s3-t3",
"type": "umlsterm",
"text": [
"vecuronium"
],
"offsets": [
[
385,
395
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0242531"
}
]
},
{
"id": "DerAnaesthesist.70460403.eng.abstr-s3-t4",
"type": "umlsterm",
"text": [
"oxide-oxygen"
],
"offsets": [
[
410,
422
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0030015"
}
]
},
{
"id": "DerAnaesthesist.70460403.eng.abstr-s3-t5",
"type": "umlsterm",
"text": [
"oxide-oxygen"
],
"offsets": [
[
410,
422
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0030054"
},
{
"db_name": "UMLS",
"db_id": "C0184633"
}
]
},
{
"id": "DerAnaesthesist.70460403.eng.abstr-s3-t6",
"type": "umlsterm",
"text": [
"mucus"
],
"offsets": [
[
444,
449
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0026727"
}
]
},
{
"id": "DerAnaesthesist.70460403.eng.abstr-s3-t7",
"type": "umlsterm",
"text": [
"transport"
],
"offsets": [
[
450,
459
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0005528"
}
]
},
{
"id": "DerAnaesthesist.70460403.eng.abstr-s3-t8",
"type": "umlsterm",
"text": [
"prospective study"
],
"offsets": [
[
300,
317
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0033522"
}
]
}
] |
[] |
[] |
[
{
"id": "DerAnaesthesist.70460403.eng.abstr-s1-r1-t1.1-t3.1",
"type": "location_of",
"arg1_id": "DerAnaesthesist.70460403.eng.abstr-s3-t1",
"arg2_id": "DerAnaesthesist.70460403.eng.abstr-s3-t3",
"normalized": []
},
{
"id": "DerAnaesthesist.70460403.eng.abstr-s2-r1-t2.1-t1.1",
"type": "measurement_of",
"arg1_id": "DerAnaesthesist.70460403.eng.abstr-s3-t2",
"arg2_id": "DerAnaesthesist.70460403.eng.abstr-s3-t1",
"normalized": []
},
{
"id": "DerAnaesthesist.70460403.eng.abstr-s2-r2-t1.1-t2.1",
"type": "affects",
"arg1_id": "DerAnaesthesist.70460403.eng.abstr-s3-t1",
"arg2_id": "DerAnaesthesist.70460403.eng.abstr-s3-t2",
"normalized": []
},
{
"id": "DerAnaesthesist.70460403.eng.abstr-s3-r1-t5.2-t3.1",
"type": "uses",
"arg1_id": "DerAnaesthesist.70460403.eng.abstr-s3-t5",
"arg2_id": "DerAnaesthesist.70460403.eng.abstr-s3-t3",
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},
{
"id": "DerAnaesthesist.70460403.eng.abstr-s3-r2-t6.1-t3.1",
"type": "consists_of",
"arg1_id": "DerAnaesthesist.70460403.eng.abstr-s3-t6",
"arg2_id": "DerAnaesthesist.70460403.eng.abstr-s3-t3",
"normalized": []
},
{
"id": "DerAnaesthesist.70460403.eng.abstr-s3-r3-t8.1-t7.1",
"type": "measures",
"arg1_id": "DerAnaesthesist.70460403.eng.abstr-s3-t8",
"arg2_id": "DerAnaesthesist.70460403.eng.abstr-s3-t7",
"normalized": []
},
{
"id": "DerAnaesthesist.70460403.eng.abstr-s3-r4-t3.1-t2.1",
"type": "interacts_with",
"arg1_id": "DerAnaesthesist.70460403.eng.abstr-s3-t3",
"arg2_id": "DerAnaesthesist.70460403.eng.abstr-s3-t2",
"normalized": []
},
{
"id": "DerAnaesthesist.70460403.eng.abstr-s3-r5-t6.1-t2.1",
"type": "consists_of",
"arg1_id": "DerAnaesthesist.70460403.eng.abstr-s3-t6",
"arg2_id": "DerAnaesthesist.70460403.eng.abstr-s3-t2",
"normalized": []
},
{
"id": "DerAnaesthesist.70460403.eng.abstr-s3-r6-t1.1-t5.1",
"type": "interacts_with",
"arg1_id": "DerAnaesthesist.70460403.eng.abstr-s3-t1",
"arg2_id": "DerAnaesthesist.70460403.eng.abstr-s3-t5",
"normalized": []
},
{
"id": "DerAnaesthesist.70460403.eng.abstr-s3-r7-t5.2-t7.1",
"type": "affects",
"arg1_id": "DerAnaesthesist.70460403.eng.abstr-s3-t5",
"arg2_id": "DerAnaesthesist.70460403.eng.abstr-s3-t7",
"normalized": []
},
{
"id": "DerAnaesthesist.70460403.eng.abstr-s3-r8-t6.1-t1.1",
"type": "consists_of",
"arg1_id": "DerAnaesthesist.70460403.eng.abstr-s3-t6",
"arg2_id": "DerAnaesthesist.70460403.eng.abstr-s3-t1",
"normalized": []
},
{
"id": "DerAnaesthesist.70460403.eng.abstr-s3-r9-t5.2-t2.1",
"type": "uses",
"arg1_id": "DerAnaesthesist.70460403.eng.abstr-s3-t5",
"arg2_id": "DerAnaesthesist.70460403.eng.abstr-s3-t2",
"normalized": []
},
{
"id": "DerAnaesthesist.70460403.eng.abstr-s3-r10-t8.1-t6.1",
"type": "measures",
"arg1_id": "DerAnaesthesist.70460403.eng.abstr-s3-t8",
"arg2_id": "DerAnaesthesist.70460403.eng.abstr-s3-t6",
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},
{
"id": "DerAnaesthesist.70460403.eng.abstr-s3-r11-t1.1-t3.1",
"type": "interacts_with",
"arg1_id": "DerAnaesthesist.70460403.eng.abstr-s3-t1",
"arg2_id": "DerAnaesthesist.70460403.eng.abstr-s3-t3",
"normalized": []
},
{
"id": "DerAnaesthesist.70460403.eng.abstr-s3-r12-t2.1-t5.1",
"type": "interacts_with",
"arg1_id": "DerAnaesthesist.70460403.eng.abstr-s3-t2",
"arg2_id": "DerAnaesthesist.70460403.eng.abstr-s3-t5",
"normalized": []
},
{
"id": "DerAnaesthesist.70460403.eng.abstr-s3-r13-t8.1-t5.1",
"type": "measures",
"arg1_id": "DerAnaesthesist.70460403.eng.abstr-s3-t8",
"arg2_id": "DerAnaesthesist.70460403.eng.abstr-s3-t5",
"normalized": []
},
{
"id": "DerAnaesthesist.70460403.eng.abstr-s3-r14-t7.1-t6.1",
"type": "produces",
"arg1_id": "DerAnaesthesist.70460403.eng.abstr-s3-t7",
"arg2_id": "DerAnaesthesist.70460403.eng.abstr-s3-t6",
"normalized": []
},
{
"id": "DerAnaesthesist.70460403.eng.abstr-s3-r15-t2.1-t3.1",
"type": "interacts_with",
"arg1_id": "DerAnaesthesist.70460403.eng.abstr-s3-t2",
"arg2_id": "DerAnaesthesist.70460403.eng.abstr-s3-t3",
"normalized": []
},
{
"id": "DerAnaesthesist.70460403.eng.abstr-s3-r16-t5.2-t1.1",
"type": "uses",
"arg1_id": "DerAnaesthesist.70460403.eng.abstr-s3-t5",
"arg2_id": "DerAnaesthesist.70460403.eng.abstr-s3-t1",
"normalized": []
},
{
"id": "DerAnaesthesist.70460403.eng.abstr-s3-r17-t5.1-t2.1",
"type": "interacts_with",
"arg1_id": "DerAnaesthesist.70460403.eng.abstr-s3-t5",
"arg2_id": "DerAnaesthesist.70460403.eng.abstr-s3-t2",
"normalized": []
},
{
"id": "DerAnaesthesist.70460403.eng.abstr-s3-r18-t3.1-t5.1",
"type": "interacts_with",
"arg1_id": "DerAnaesthesist.70460403.eng.abstr-s3-t3",
"arg2_id": "DerAnaesthesist.70460403.eng.abstr-s3-t5",
"normalized": []
},
{
"id": "DerAnaesthesist.70460403.eng.abstr-s3-r19-t1.1-t7.1",
"type": "affects",
"arg1_id": "DerAnaesthesist.70460403.eng.abstr-s3-t1",
"arg2_id": "DerAnaesthesist.70460403.eng.abstr-s3-t7",
"normalized": []
},
{
"id": "DerAnaesthesist.70460403.eng.abstr-s3-r20-t2.1-t1.1",
"type": "interacts_with",
"arg1_id": "DerAnaesthesist.70460403.eng.abstr-s3-t2",
"arg2_id": "DerAnaesthesist.70460403.eng.abstr-s3-t1",
"normalized": []
},
{
"id": "DerAnaesthesist.70460403.eng.abstr-s3-r21-t2.1-t7.1",
"type": "affects",
"arg1_id": "DerAnaesthesist.70460403.eng.abstr-s3-t2",
"arg2_id": "DerAnaesthesist.70460403.eng.abstr-s3-t7",
"normalized": []
},
{
"id": "DerAnaesthesist.70460403.eng.abstr-s3-r22-t3.1-t7.1",
"type": "affects",
"arg1_id": "DerAnaesthesist.70460403.eng.abstr-s3-t3",
"arg2_id": "DerAnaesthesist.70460403.eng.abstr-s3-t7",
"normalized": []
},
{
"id": "DerAnaesthesist.70460403.eng.abstr-s3-r23-t8.1-t3.1",
"type": "measures",
"arg1_id": "DerAnaesthesist.70460403.eng.abstr-s3-t8",
"arg2_id": "DerAnaesthesist.70460403.eng.abstr-s3-t3",
"normalized": []
},
{
"id": "DerAnaesthesist.70460403.eng.abstr-s3-r24-t3.1-t1.1",
"type": "interacts_with",
"arg1_id": "DerAnaesthesist.70460403.eng.abstr-s3-t3",
"arg2_id": "DerAnaesthesist.70460403.eng.abstr-s3-t1",
"normalized": []
},
{
"id": "DerAnaesthesist.70460403.eng.abstr-s3-r25-t8.1-t5.2",
"type": "conceptual_part_of",
"arg1_id": "DerAnaesthesist.70460403.eng.abstr-s3-t8",
"arg2_id": "DerAnaesthesist.70460403.eng.abstr-s3-t5",
"normalized": []
},
{
"id": "DerAnaesthesist.70460403.eng.abstr-s3-r26-t8.1-t7.1",
"type": "measurement_of",
"arg1_id": "DerAnaesthesist.70460403.eng.abstr-s3-t8",
"arg2_id": "DerAnaesthesist.70460403.eng.abstr-s3-t7",
"normalized": []
},
{
"id": "DerAnaesthesist.70460403.eng.abstr-s3-r27-t5.1-t7.1",
"type": "affects",
"arg1_id": "DerAnaesthesist.70460403.eng.abstr-s3-t5",
"arg2_id": "DerAnaesthesist.70460403.eng.abstr-s3-t7",
"normalized": []
},
{
"id": "DerAnaesthesist.70460403.eng.abstr-s3-r28-t1.1-t2.1",
"type": "interacts_with",
"arg1_id": "DerAnaesthesist.70460403.eng.abstr-s3-t1",
"arg2_id": "DerAnaesthesist.70460403.eng.abstr-s3-t2",
"normalized": []
},
{
"id": "DerAnaesthesist.70460403.eng.abstr-s3-r29-t8.1-t2.1",
"type": "measures",
"arg1_id": "DerAnaesthesist.70460403.eng.abstr-s3-t8",
"arg2_id": "DerAnaesthesist.70460403.eng.abstr-s3-t2",
"normalized": []
},
{
"id": "DerAnaesthesist.70460403.eng.abstr-s3-r30-t5.1-t3.1",
"type": "interacts_with",
"arg1_id": "DerAnaesthesist.70460403.eng.abstr-s3-t5",
"arg2_id": "DerAnaesthesist.70460403.eng.abstr-s3-t3",
"normalized": []
},
{
"id": "DerAnaesthesist.70460403.eng.abstr-s3-r31-t8.1-t1.1",
"type": "measures",
"arg1_id": "DerAnaesthesist.70460403.eng.abstr-s3-t8",
"arg2_id": "DerAnaesthesist.70460403.eng.abstr-s3-t1",
"normalized": []
},
{
"id": "DerAnaesthesist.70460403.eng.abstr-s3-r32-t5.1-t1.1",
"type": "interacts_with",
"arg1_id": "DerAnaesthesist.70460403.eng.abstr-s3-t5",
"arg2_id": "DerAnaesthesist.70460403.eng.abstr-s3-t1",
"normalized": []
}
] |
DerAnaesthesist.70460408.eng.abstr
|
DerAnaesthesist.70460408.eng.abstr
|
[
{
"id": "DerAnaesthesist.70460408.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The development of cardiopulmonary bypass ( CPB ) to support the systemic circulation during cardiac surgical procedures became a clinical reality in 1953. Although the use of CPB for the treatment of post-infarction cardiogenic shock met with little success , intra-aortic balloon counterpulsation was used successfully in 1968 to reduce ischaemic injury in a patient with cardiogenic shock . Today , a broad spectrum of circulatory assist devices for short- and long-term application is available . Three major indication groups for the use of support devices are established . In low-cardiac-output syndrome after cardiac surgical procedures , short-term devices are utilised to enable myocardial recovery . In transplantation candidates suffering from drug-resistant pump failure , the implantation of long-term devices as a bridge to heart transplantation is indicated , and in NYHA class IV patients with contraindications to heart transplantation , the implantation of long-term devices as an alternative to transplantation is under discussion . In the literature , post-cardiotomy support survival is less than 30% on average . About 70% of mechanically bridged patients have survived to undergo heart transplantation and were transplanted with over 90% survival . Major problems during mechanical support are infection , bleeding , and thrombembolism . In view of patients ' natural course without support , these clinical results are favourable ."
],
"offsets": [
[
0,
1456
]
]
}
] |
[
{
"id": "DerAnaesthesist.70460408.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"development"
],
"offsets": [
[
4,
15
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0243107"
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DerAnaesthesist.70460419.eng.abstr
|
DerAnaesthesist.70460419.eng.abstr
|
[
{
"id": "DerAnaesthesist.70460419.eng.abstr-passage-0",
"type": "abstract",
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"We performed a prospective multi-center study in order to determine the causes of 30-day perioperative mortality ."
],
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[
0,
114
]
]
}
] |
[
{
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"causes"
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{
"id": "DerAnaesthesist.70460419.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"mortality"
],
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},
{
"db_name": "UMLS",
"db_id": "C0026565"
}
]
}
] |
[] |
[] |
[] |
DerAnaesthesist.70460428.eng.abstr
|
DerAnaesthesist.70460428.eng.abstr
|
[
{
"id": "DerAnaesthesist.70460428.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A 22-year-old male suffering from neuropathic pain in his right leg had sufficient analgesia with oral tilidin 300 mg per day . Nevertheless , the general practitioner decided to change the therapy to transdermal fentanyl . Having cut a fentanyl patch ( 50 µg/h) into pieces , he applied one-fourth of the patch ; 60 min later the patient developed signs of opioid intoxication , including heavy sedation , nausea and respiratory depression . After the patch was removed another 60 min later , the patient made a complete recovery . The risks following inappropriate application of transdermal fentanyl are discussed ."
],
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[
0,
618
]
]
}
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"male"
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"id": "DerAnaesthesist.70460428.eng.abstr-s1-t2",
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"pain"
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{
"id": "DerAnaesthesist.70460428.eng.abstr-s1-t3",
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"right"
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"id": "DerAnaesthesist.70460428.eng.abstr-s1-t4",
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"leg"
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"id": "DerAnaesthesist.70460428.eng.abstr-s1-t5",
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"analgesia"
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"id": "DerAnaesthesist.70460428.eng.abstr-s2-t1",
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"therapy"
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"id": "DerAnaesthesist.70460428.eng.abstr-s2-t2",
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"id": "DerAnaesthesist.70460428.eng.abstr-s2-t3",
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"id": "DerAnaesthesist.70460428.eng.abstr-s3-t2",
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"signs"
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"id": "DerAnaesthesist.70460428.eng.abstr-s3-t4",
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"opioid"
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"id": "DerAnaesthesist.70460428.eng.abstr-s3-t5",
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"id": "DerAnaesthesist.70460428.eng.abstr-s3-t7",
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"depression"
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430,
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"id": "DerAnaesthesist.70460428.eng.abstr-s4-t1",
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"id": "DerAnaesthesist.70460428.eng.abstr-s5-t1",
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"id": "DerAnaesthesist.70460428.eng.abstr-s5-t2",
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] |
[] |
[] |
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DerAnaesthesist.70460430.eng.abstr
|
DerAnaesthesist.70460430.eng.abstr
|
[
{
"id": "DerAnaesthesist.70460430.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Spinal anaesthesia for outpatients is a method that is not favoured in several reports without having representative data . It was our desire to investigate whether this method could be used without having dangerous side effects ."
],
"offsets": [
[
0,
230
]
]
}
] |
[
{
"id": "DerAnaesthesist.70460430.eng.abstr-s1-t1",
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"text": [
"outpatients"
],
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[
23,
34
]
],
"normalized": [
{
"db_name": "UMLS",
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}
]
},
{
"id": "DerAnaesthesist.70460430.eng.abstr-s1-t2",
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"method"
],
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46
]
],
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}
]
},
{
"id": "DerAnaesthesist.70460430.eng.abstr-s1-t3",
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"text": [
"Spinal anaesthesia"
],
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[
0,
18
]
],
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"db_name": "UMLS",
"db_id": "C0002928"
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"id": "DerAnaesthesist.70460430.eng.abstr-s2-t1",
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"method"
],
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[
170,
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{
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}
]
},
{
"id": "DerAnaesthesist.70460430.eng.abstr-s2-t2",
"type": "umlsterm",
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"side effects"
],
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[
216,
228
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0001688"
}
]
}
] |
[] |
[] |
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"id": "DerAnaesthesist.70460430.eng.abstr-s2-r1-t2.1-t1.1",
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DerAnaesthesist.70460434.eng.abstr
|
DerAnaesthesist.70460434.eng.abstr
|
[
{
"id": "DerAnaesthesist.70460434.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Introduction : There is no data available on the action of etomidate on ion currents in human neuronal cells . Therefore the effects of etomidate on a human neuronal delayed rectifer potassium current were investigated ."
],
"offsets": [
[
0,
220
]
]
}
] |
[
{
"id": "DerAnaesthesist.70460434.eng.abstr-s1-t1",
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"text": [
"etomidate"
],
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[
59,
68
]
],
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"db_name": "UMLS",
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]
},
{
"id": "DerAnaesthesist.70460434.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"ion"
],
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[
72,
75
]
],
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{
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},
{
"id": "DerAnaesthesist.70460434.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"human"
],
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[
88,
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[] |
[] |
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DerAnaesthesist.70460481.eng.abstr
|
DerAnaesthesist.70460481.eng.abstr
|
[
{
"id": "DerAnaesthesist.70460481.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Cisatracurium ( 51W89) is one of the ten stereoisomers of atracurium , accounting for about 15% of the racemate . The ED95 of cisatracurium was determined to be about 50 µg/kg ( cation , molecular weight 929 ) , while the ED95 of atracurium ( besylate salt , molecular weight 1245 ) was 250 µg/kg. Thus , on a molar basis in adult patients , cisatracurium is about 3.5 times as potent as the racemic atracurium mixture . We compared atracurium with cisatracurium in healthy adult patients and found an almost identical pharmacodynamic profile . In children , an ED95 of about 40 µg/kg was determined , while a 1-min-longer onset of cisatracurium was found in geriatric than in young adult patients . The presence of chronic renal failure did not prolong the duration of action of cisatracurium . The recovery of neuromuscular transmission from a cisatracurium infusion of up to 145 h was investigated in intensive care unit patients . Their time from the end of infusion to a train-of-four ratio > 0.7 ( 68 +/- 18 min ) was on average only some 70% longer than after an infusion of cisatracurium for 2 h in normal surgical patients . In another study , no signs of histamine release nor any clinically relevant cardiovascular effects of cisatracurium were found in doses up to eight times ED95."
],
"offsets": [
[
0,
1294
]
]
}
] |
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DerAnaesthesist.70460486.eng.abstr
|
DerAnaesthesist.70460486.eng.abstr
|
[
{
"id": "DerAnaesthesist.70460486.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Cisatracurium ( 51W89, Nimbex , Glaxo-Wellcome ) , an intermediate-acting non-depolarizing neuromuscular blocking agent , is a stereoisomer of atracurium . Histamine releasing propensities and serum tryptase level have been investigated after administration of cisatracurium ( 3xED95 , 5xED95 ) or vecuronium ( 3xED90 ) in surgical patients . Methods : After approval by our institutional review board , 62 patients ( ASA I-II ) were randomly assigned to three groups to receive either 3xED95 or 5xED95 cisatracurium , or 3xED90 vecuronium as a rapid bolus . A prick test was done the day before by scarification of the skin in the forearm . After premedication with 2 mg lormetazepam , anaesthesia was induced with thiopentone ( 4-12 mg/kg ) and maintained with O2/N2O and isoflurane ( 1.5-2 vol . % ) . Six minutes after thiopentone , the patients received the relaxant , and after further 6 min 0.1-0.2 mg fentanyl was given and the trachea was intubated . Heart rate ( HR ) and blood pressure ( BP ) were monitored every minute . Blood samples for histamine were withdrawn 5 min prior 3 and 5 min after each drug administration ( thiopentone , relaxants ) . Plasma histamine was measured by radioimmunoassay ( RIA ) with a sensitivity of approximately 10 pg/ml . Additionally , serum tryptase was measured by RIA at baseline ( -10 and -1 min ) and 15 and 60 min after the relaxant administration . Levels for histamine > 1000 pg/ml and for tryptase > 2 µg/ml were considered significant . Cutaneous signs of histamine release were documented . Results : Ten patients showed a positive prick-test reaction . Only after thiopentone some cutaneous signs ( 4 flush , 1 erythema ) of histamine release were observed . There were no cutaneous signs of histamine release correlating with cardiovascular changes . Analysis of the blood samples demonstrated no significant increase in the histamine level in all three groups . Only in 1 patient was a significant higher histamine level ( 1133 pg/ml ) measured 5 min after 5xED95 cisatracurium . All measurements of serum tryptase were within the physiological limits . Discussion : In this study , with the particular time course of drug administration , neither cisatracurium nor vecuronium increased plasma histamine levels . Only after 5xED95 cisatracurium was 1 elevated histamine level documented after 5 min . In several studies increased histamine levels have been described , but without clinical manifestations . It is known that cutaneous signs can occur without increased plasma histamine levels due to the structural heterogeneity of mast cells . The cutaneous reactions in this study were caused by thiopentone . The tryptase values were within normal limits even in the patient with histamine release . No relationship between the positive results in the prick test and the incidence of cutaneous reactions and/or histamine release for drugs used in the induction of anaesthesia was observed . Whether cisatracurium has a potential for immunologic release is unknown ."
],
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] |
DerAnaesthesist.70460493.eng.abstr
|
DerAnaesthesist.70460493.eng.abstr
|
[
{
"id": "DerAnaesthesist.70460493.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Recent studies have shown different results concerning the effects of smoking on neuromuscular blocking agents . Some reports indicate that smokers need higher doses of vecuronium , but are more sensitive to atracurium . The aim of this study was to evaluate the effects of smoking on onset and recovery time after a single 0.6 mg/kg intubating dose of rocuronium an analog of vecuronium ."
],
"offsets": [
[
0,
389
]
]
}
] |
[
{
"id": "DerAnaesthesist.70460493.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"smoking"
],
"offsets": [
[
70,
77
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0037369"
}
]
},
{
"id": "DerAnaesthesist.70460493.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"neuromuscular blocking"
],
"offsets": [
[
81,
103
]
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[] |
[] |
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DerAnaesthesist.70460504.eng.abstr
|
DerAnaesthesist.70460504.eng.abstr
|
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[] |
[] |
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DerAnaesthesist.70460516.eng.abstr
|
DerAnaesthesist.70460516.eng.abstr
|
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"There is still a significant lack of treatment and rehabilitation facilities for chronic pain patients in Germany today . Most of all the treatment of low back pain and widespread pain syndromes or panalgesia is time consuming and complicated . The main problem of anaesthesiological pain clinics is the increase of these complex pain syndromes in the last years . The definition of chronic pain is a contiuous noxious input modulated and compounded by the prolonged or recurrent nature of chronic state and further complicated by a multitude of economic and psychosocial factors . It is now clear that no one discipline or mode will suffice . Only a multidisciplinary and intensive approache will prevail , as discussed in this article . Unfortunately these multidisciplinary pain units are nearly not existing in Gemany just as little as control of the effectiveness of pain treatment ."
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DerAnaesthesist.70460528.eng.abstr
|
DerAnaesthesist.70460528.eng.abstr
|
[
{
"id": "DerAnaesthesist.70460528.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The sensitivity of ambulatory electrocardiography ( Holter ECG ) for detecting ischaemia is relatively low . A case report of an inferior infarction missed by three-lead Holter monitoring that included a modified lead aVF especially places its sensitivity for detecting inferior ischaemia and infarction in question . Therefore , the present study evaluated the sensitivity of nine bipolar Holter leads for detecting isolated inferior Q-wave infarctions , and compared the sensitivity of the modified leads II , III , and aVF of the Holter ECG with the sensitivity of the \" corresponding \" leads of the standard ECG ."
],
"offsets": [
[
0,
617
]
]
}
] |
[
{
"id": "DerAnaesthesist.70460528.eng.abstr-s1-t1",
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"sensitivity"
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4,
15
]
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{
"id": "DerAnaesthesist.70460528.eng.abstr-s1-t2",
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"electrocardiography"
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30,
49
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{
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{
"id": "DerAnaesthesist.70460528.eng.abstr-s1-t3",
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"electrocardiography"
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30,
49
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},
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"id": "DerAnaesthesist.70460528.eng.abstr-s1-t4",
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"text": [
"ECG"
],
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},
{
"id": "DerAnaesthesist.70460528.eng.abstr-s1-t5",
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"text": [
"ischaemia"
],
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[
79,
88
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],
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{
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}
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},
{
"id": "DerAnaesthesist.70460528.eng.abstr-s1-t6",
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"ambulatory electrocardiography"
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[
19,
49
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],
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{
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}
]
},
{
"id": "DerAnaesthesist.70460528.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"infarction"
],
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[
138,
148
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],
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},
{
"id": "DerAnaesthesist.70460528.eng.abstr-s2-t2",
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"lead"
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"id": "DerAnaesthesist.70460528.eng.abstr-s2-t3",
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},
{
"id": "DerAnaesthesist.70460528.eng.abstr-s2-t4",
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"ischaemia"
],
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279,
288
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},
{
"id": "DerAnaesthesist.70460528.eng.abstr-s2-t5",
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"infarction"
],
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293,
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},
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"id": "DerAnaesthesist.70460528.eng.abstr-s2-t6",
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},
{
"id": "DerAnaesthesist.70460528.eng.abstr-s2-t7",
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{
"id": "DerAnaesthesist.70460528.eng.abstr-s3-t2",
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"id": "DerAnaesthesist.70460528.eng.abstr-s3-t4",
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}
] |
[] |
[] |
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}
] |
DerAnaesthesist.70460532.eng.abstr
|
DerAnaesthesist.70460532.eng.abstr
|
[
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"id": "DerAnaesthesist.70460532.eng.abstr-passage-0",
"type": "abstract",
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"Background : The purpose of this study was to determine obstetrical pain management practices for labour for spontaneous and operative vaginal deliveries since there were no comparative German data available for the past 10 years . Methods : A mail survey was sent to the chief anaesthetists of all hospitals in North Rhine-Westfalia designated to have obstetrical beds . The confidential and standardised questionnaire consisted of 24 mainly multiple-choice questions relating to general issues and methods of analgesia and anaesthesia for vaginal deliveries . Results : In all , 118 completed replies to 258 sent questionnaires were received , giving a response rate of 46% . Among the 118 hospitals there were 79,157 vaginal deliveries annually . All participating hospitals practiced either systemic analgesics/spasmolytics and/or regional-anaesthetic methods ( Table 2 ) . Perineal local infiltration ( 23.7% of vaginal deliveries , in 99% of cases performed by the obstetrician ) and epidural analgesia ( 23.2% of vaginal deliveries , in 81% of cases performed by an anaesthetist ) were the commonest regional-anaesthetic methods . Pudendal nerve blocks were performed in 18.5% of vaginal deliveries ( Table 1 ) . Of all participating hospitals , 97% provided a 24-h epidural service . The method of epidural anaesthesia was widely homogeneous in all 118 hospitals ( Table 3 ) . Other methods of regional analgesia ( i.e. , epidural infusions or patient-controlled epidural analgesia ) were performed only rarely . Conclusions : The methods of obstetrical analgesia and anaesthesia are on a high level and show a broad homogeneity in all hospitals . Overall , the results indicate , in comparison to former studies and in common with other countries , steadily increasing use of regional anaesthesia performed by anaesthetists in contrast to decreasing numbers of local infiltrations performed by obstetricians ."
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DerAnaesthesist.70460536.eng.abstr
|
DerAnaesthesist.70460536.eng.abstr
|
[
{
"id": "DerAnaesthesist.70460536.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Bacteraemia and septicaemia are generally thought to be relative or absolute contraindications for central neural axis ( CNA ) blocks . Postulated mechanisms for haematogenous infection of the central nervous system ( CNS ) caused by subarachnoid or epidural puncture might be an accidental vessel puncture , a change of pressure in the subarachnoid space , and the induction of a \" locus minoris resistentiae . \" Infectious complications of diagnostic lumbar puncture , spinal or epidural anaesthesia are very rare . Although in animals meningitis can be induced by subarachnoid puncture during bactaeremia , there is no study that proves an increased risk for bacteraemic patients . Transient bacteraemia is common , especially in urological and obstetrical-gynecological procedures that are often done in regional anaesthesia , but the incidence of infectious complications is low . This review investigates the few published cases in which a haematogenous infection of the CNS may have been caused by regional anaesthesia . Based on current knowledge , bacteraemia cannot be an absolute , but only a relative contraindication for CNA blocks . Antibiotic chemoprophylaxis should be given before the puncture and the patients must be closely followed after the anaesthesia , particularly for the development of spinal epidural abscess . Because of the possibly increased risk of infectious complications , informed consent should be obtained from the patient ."
],
"offsets": [
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0,
1462
]
]
}
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},
{
"id": "DerAnaesthesist.70460536.eng.abstr-s8-r26-t8.1-t4.1",
"type": "occurs_in",
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"arg2_id": "DerAnaesthesist.70460536.eng.abstr-s9-t4",
"normalized": []
},
{
"id": "DerAnaesthesist.70460536.eng.abstr-s8-r27-t6.1-t5.1",
"type": "result_of",
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"arg2_id": "DerAnaesthesist.70460536.eng.abstr-s9-t5",
"normalized": []
},
{
"id": "DerAnaesthesist.70460536.eng.abstr-s8-r28-t7.1-t6.1",
"type": "degree_of",
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"normalized": []
},
{
"id": "DerAnaesthesist.70460536.eng.abstr-s8-r29-t1.1-t5.1",
"type": "affects",
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"arg2_id": "DerAnaesthesist.70460536.eng.abstr-s9-t5",
"normalized": []
},
{
"id": "DerAnaesthesist.70460536.eng.abstr-s8-r30-t6.1-t3.1",
"type": "associated_with",
"arg1_id": "DerAnaesthesist.70460536.eng.abstr-s8-t6",
"arg2_id": "DerAnaesthesist.70460536.eng.abstr-s9-t3",
"normalized": []
},
{
"id": "DerAnaesthesist.70460536.eng.abstr-s8-r31-t3.1-t2.1",
"type": "precedes",
"arg1_id": "DerAnaesthesist.70460536.eng.abstr-s9-t3",
"arg2_id": "DerAnaesthesist.70460536.eng.abstr-s9-t2",
"normalized": []
},
{
"id": "DerAnaesthesist.70460536.eng.abstr-s8-r32-t6.1-t2.1",
"type": "associated_with",
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"normalized": []
},
{
"id": "DerAnaesthesist.70460536.eng.abstr-s8-r33-t2.1-t5.1",
"type": "affects",
"arg1_id": "DerAnaesthesist.70460536.eng.abstr-s9-t2",
"arg2_id": "DerAnaesthesist.70460536.eng.abstr-s9-t5",
"normalized": []
},
{
"id": "DerAnaesthesist.70460536.eng.abstr-s8-r34-t8.1-t5.1",
"type": "result_of",
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"normalized": []
},
{
"id": "DerAnaesthesist.70460536.eng.abstr-s8-r35-t5.1-t7.1",
"type": "result_of",
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"arg2_id": "DerAnaesthesist.70460536.eng.abstr-s8-t7",
"normalized": []
},
{
"id": "DerAnaesthesist.70460536.eng.abstr-s8-r36-t3.1-t5.1",
"type": "affects",
"arg1_id": "DerAnaesthesist.70460536.eng.abstr-s9-t3",
"arg2_id": "DerAnaesthesist.70460536.eng.abstr-s9-t5",
"normalized": []
},
{
"id": "DerAnaesthesist.70460536.eng.abstr-s8-r37-t2.1-t1.1",
"type": "uses",
"arg1_id": "DerAnaesthesist.70460536.eng.abstr-s9-t2",
"arg2_id": "DerAnaesthesist.70460536.eng.abstr-s9-t1",
"normalized": []
},
{
"id": "DerAnaesthesist.70460536.eng.abstr-s8-r38-t6.1-t8.1",
"type": "degree_of",
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"arg2_id": "DerAnaesthesist.70460536.eng.abstr-s8-t8",
"normalized": []
},
{
"id": "DerAnaesthesist.70460536.eng.abstr-s8-r39-t2.1-t8.1",
"type": "associated_with",
"arg1_id": "DerAnaesthesist.70460536.eng.abstr-s9-t2",
"arg2_id": "DerAnaesthesist.70460536.eng.abstr-s8-t8",
"normalized": []
},
{
"id": "DerAnaesthesist.70460536.eng.abstr-s8-r40-t7.1-t3.1",
"type": "associated_with",
"arg1_id": "DerAnaesthesist.70460536.eng.abstr-s8-t7",
"arg2_id": "DerAnaesthesist.70460536.eng.abstr-s9-t3",
"normalized": []
},
{
"id": "DerAnaesthesist.70460536.eng.abstr-s9-r1-t2.1-t5.1",
"type": "associated_with",
"arg1_id": "DerAnaesthesist.70460536.eng.abstr-s9-t2",
"arg2_id": "DerAnaesthesist.70460536.eng.abstr-s9-t5",
"normalized": []
},
{
"id": "DerAnaesthesist.70460536.eng.abstr-s9-r2-t4.1-t5.1",
"type": "evaluation_of",
"arg1_id": "DerAnaesthesist.70460536.eng.abstr-s9-t4",
"arg2_id": "DerAnaesthesist.70460536.eng.abstr-s9-t5",
"normalized": []
},
{
"id": "DerAnaesthesist.70460536.eng.abstr-s9-r3-t1.1-t5.1",
"type": "evaluation_of",
"arg1_id": "DerAnaesthesist.70460536.eng.abstr-s9-t1",
"arg2_id": "DerAnaesthesist.70460536.eng.abstr-s9-t5",
"normalized": []
},
{
"id": "DerAnaesthesist.70460536.eng.abstr-s9-r4-t5.1-t2.1",
"type": "associated_with",
"arg1_id": "DerAnaesthesist.70460536.eng.abstr-s9-t5",
"arg2_id": "DerAnaesthesist.70460536.eng.abstr-s9-t2",
"normalized": []
},
{
"id": "DerAnaesthesist.70460536.eng.abstr-s9-r5-t4.1-t5.1",
"type": "isa",
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"arg2_id": "DerAnaesthesist.70460536.eng.abstr-s9-t5",
"normalized": []
},
{
"id": "DerAnaesthesist.70460536.eng.abstr-s9-r6-t1.1-t5.1",
"type": "isa",
"arg1_id": "DerAnaesthesist.70460536.eng.abstr-s9-t1",
"arg2_id": "DerAnaesthesist.70460536.eng.abstr-s9-t5",
"normalized": []
},
{
"id": "DerAnaesthesist.70460536.eng.abstr-s9-r7-t2.1-t5.1",
"type": "performs",
"arg1_id": "DerAnaesthesist.70460536.eng.abstr-s9-t2",
"arg2_id": "DerAnaesthesist.70460536.eng.abstr-s9-t5",
"normalized": []
}
] |
DerAnaesthesist.70460583.eng.abstr
|
DerAnaesthesist.70460583.eng.abstr
|
[
{
"id": "DerAnaesthesist.70460583.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Objective : To investigate the incidence of postoperative nausea and vomiting ( PONV ) depending on the administration time of ondansetron ."
],
"offsets": [
[
0,
140
]
]
}
] |
[
{
"id": "DerAnaesthesist.70460583.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"Objective"
],
"offsets": [
[
0,
9
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0018017"
}
]
},
{
"id": "DerAnaesthesist.70460583.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"incidence"
],
"offsets": [
[
31,
40
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0220856"
},
{
"db_name": "UMLS",
"db_id": "C0021149"
}
]
},
{
"id": "DerAnaesthesist.70460583.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"postoperative"
],
"offsets": [
[
44,
57
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0032790"
}
]
},
{
"id": "DerAnaesthesist.70460583.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"nausea"
],
"offsets": [
[
58,
64
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0027497"
}
]
},
{
"id": "DerAnaesthesist.70460583.eng.abstr-s1-t5",
"type": "umlsterm",
"text": [
"vomiting"
],
"offsets": [
[
69,
77
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0042963"
}
]
},
{
"id": "DerAnaesthesist.70460583.eng.abstr-s1-t6",
"type": "umlsterm",
"text": [
"PONV"
],
"offsets": [
[
80,
84
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0520909"
}
]
},
{
"id": "DerAnaesthesist.70460583.eng.abstr-s1-t7",
"type": "umlsterm",
"text": [
"administration"
],
"offsets": [
[
104,
118
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0001554"
}
]
},
{
"id": "DerAnaesthesist.70460583.eng.abstr-s1-t8",
"type": "umlsterm",
"text": [
"time"
],
"offsets": [
[
119,
123
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0040223"
}
]
},
{
"id": "DerAnaesthesist.70460583.eng.abstr-s1-t9",
"type": "umlsterm",
"text": [
"ondansetron"
],
"offsets": [
[
127,
138
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0061851"
}
]
},
{
"id": "DerAnaesthesist.70460583.eng.abstr-s1-t10",
"type": "umlsterm",
"text": [
"postoperative nausea"
],
"offsets": [
[
44,
64
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0520904"
}
]
}
] |
[] |
[] |
[
{
"id": "DerAnaesthesist.70460583.eng.abstr-s1-r1-t9.1-t6.1",
"type": "affects",
"arg1_id": "DerAnaesthesist.70460583.eng.abstr-s1-t9",
"arg2_id": "DerAnaesthesist.70460583.eng.abstr-s1-t6",
"normalized": []
},
{
"id": "DerAnaesthesist.70460583.eng.abstr-s1-r2-t9.1-t4.1",
"type": "treats",
"arg1_id": "DerAnaesthesist.70460583.eng.abstr-s1-t9",
"arg2_id": "DerAnaesthesist.70460583.eng.abstr-s1-t4",
"normalized": []
},
{
"id": "DerAnaesthesist.70460583.eng.abstr-s1-r3-t7.1-t10.1",
"type": "associated_with",
"arg1_id": "DerAnaesthesist.70460583.eng.abstr-s1-t7",
"arg2_id": "DerAnaesthesist.70460583.eng.abstr-s1-t10",
"normalized": []
},
{
"id": "DerAnaesthesist.70460583.eng.abstr-s1-r4-t9.1-t10.1",
"type": "diagnoses",
"arg1_id": "DerAnaesthesist.70460583.eng.abstr-s1-t9",
"arg2_id": "DerAnaesthesist.70460583.eng.abstr-s1-t10",
"normalized": []
},
{
"id": "DerAnaesthesist.70460583.eng.abstr-s1-r5-t9.1-t6.1",
"type": "treats",
"arg1_id": "DerAnaesthesist.70460583.eng.abstr-s1-t9",
"arg2_id": "DerAnaesthesist.70460583.eng.abstr-s1-t6",
"normalized": []
},
{
"id": "DerAnaesthesist.70460583.eng.abstr-s1-r6-t6.1-t7.1",
"type": "associated_with",
"arg1_id": "DerAnaesthesist.70460583.eng.abstr-s1-t6",
"arg2_id": "DerAnaesthesist.70460583.eng.abstr-s1-t7",
"normalized": []
},
{
"id": "DerAnaesthesist.70460583.eng.abstr-s1-r7-t6.1-t5.1",
"type": "associated_with",
"arg1_id": "DerAnaesthesist.70460583.eng.abstr-s1-t6",
"arg2_id": "DerAnaesthesist.70460583.eng.abstr-s1-t5",
"normalized": []
},
{
"id": "DerAnaesthesist.70460583.eng.abstr-s1-r8-t6.1-t4.1",
"type": "associated_with",
"arg1_id": "DerAnaesthesist.70460583.eng.abstr-s1-t6",
"arg2_id": "DerAnaesthesist.70460583.eng.abstr-s1-t4",
"normalized": []
},
{
"id": "DerAnaesthesist.70460583.eng.abstr-s1-r9-t10.1-t7.1",
"type": "associated_with",
"arg1_id": "DerAnaesthesist.70460583.eng.abstr-s1-t10",
"arg2_id": "DerAnaesthesist.70460583.eng.abstr-s1-t7",
"normalized": []
},
{
"id": "DerAnaesthesist.70460583.eng.abstr-s1-r10-t10.1-t6.1",
"type": "associated_with",
"arg1_id": "DerAnaesthesist.70460583.eng.abstr-s1-t10",
"arg2_id": "DerAnaesthesist.70460583.eng.abstr-s1-t6",
"normalized": []
},
{
"id": "DerAnaesthesist.70460583.eng.abstr-s1-r11-t9.1-t5.1",
"type": "treats",
"arg1_id": "DerAnaesthesist.70460583.eng.abstr-s1-t9",
"arg2_id": "DerAnaesthesist.70460583.eng.abstr-s1-t5",
"normalized": []
},
{
"id": "DerAnaesthesist.70460583.eng.abstr-s1-r12-t9.1-t10.1",
"type": "treats",
"arg1_id": "DerAnaesthesist.70460583.eng.abstr-s1-t9",
"arg2_id": "DerAnaesthesist.70460583.eng.abstr-s1-t10",
"normalized": []
},
{
"id": "DerAnaesthesist.70460583.eng.abstr-s1-r13-t10.1-t5.1",
"type": "associated_with",
"arg1_id": "DerAnaesthesist.70460583.eng.abstr-s1-t10",
"arg2_id": "DerAnaesthesist.70460583.eng.abstr-s1-t5",
"normalized": []
},
{
"id": "DerAnaesthesist.70460583.eng.abstr-s1-r14-t9.1-t10.1",
"type": "affects",
"arg1_id": "DerAnaesthesist.70460583.eng.abstr-s1-t9",
"arg2_id": "DerAnaesthesist.70460583.eng.abstr-s1-t10",
"normalized": []
},
{
"id": "DerAnaesthesist.70460583.eng.abstr-s1-r15-t7.1-t6.1",
"type": "associated_with",
"arg1_id": "DerAnaesthesist.70460583.eng.abstr-s1-t7",
"arg2_id": "DerAnaesthesist.70460583.eng.abstr-s1-t6",
"normalized": []
},
{
"id": "DerAnaesthesist.70460583.eng.abstr-s1-r16-t9.1-t6.1",
"type": "diagnoses",
"arg1_id": "DerAnaesthesist.70460583.eng.abstr-s1-t9",
"arg2_id": "DerAnaesthesist.70460583.eng.abstr-s1-t6",
"normalized": []
},
{
"id": "DerAnaesthesist.70460583.eng.abstr-s1-r17-t10.1-t4.1",
"type": "associated_with",
"arg1_id": "DerAnaesthesist.70460583.eng.abstr-s1-t10",
"arg2_id": "DerAnaesthesist.70460583.eng.abstr-s1-t4",
"normalized": []
},
{
"id": "DerAnaesthesist.70460583.eng.abstr-s1-r18-t6.1-t10.1",
"type": "associated_with",
"arg1_id": "DerAnaesthesist.70460583.eng.abstr-s1-t6",
"arg2_id": "DerAnaesthesist.70460583.eng.abstr-s1-t10",
"normalized": []
}
] |
DerAnaesthesist.70460588.eng.abstr
|
DerAnaesthesist.70460588.eng.abstr
|
[
{
"id": "DerAnaesthesist.70460588.eng.abstr-passage-0",
"type": "abstract",
"text": [
"To test the hypothesis that the efficacy of local anaesthetics to block nerve conduction is related the time of day ( TOD ) of drug application , we retrospectively analysed data from previous experiments on tachyphylaxis . During the course of these experiments , as a measure of drug efficacy we determined the minimal blocking concentration ( cm ) of bupivacaine in rabbit aortic nerves at several TODs . The special in situ preparation used permitted study of local anaesthetic pharmacodynamics without the influence of pharmacokinetics , making it possible to investigate the chronopharmacodynamics of these drugs by relating cms to the respective TODs of their measurement ."
],
"offsets": [
[
0,
680
]
]
}
] |
[
{
"id": "DerAnaesthesist.70460588.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"anaesthetics"
],
"offsets": [
[
50,
62
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0002932"
}
]
},
{
"id": "DerAnaesthesist.70460588.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"nerve"
],
"offsets": [
[
72,
77
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0027769"
}
]
},
{
"id": "DerAnaesthesist.70460588.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"time"
],
"offsets": [
[
104,
108
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0040223"
}
]
},
{
"id": "DerAnaesthesist.70460588.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"drug"
],
"offsets": [
[
127,
131
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0013227"
}
]
},
{
"id": "DerAnaesthesist.70460588.eng.abstr-s1-t5",
"type": "umlsterm",
"text": [
"tachyphylaxis"
],
"offsets": [
[
208,
221
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0039242"
}
]
},
{
"id": "DerAnaesthesist.70460588.eng.abstr-s1-t6",
"type": "umlsterm",
"text": [
"local anaesthetics"
],
"offsets": [
[
44,
62
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0002934"
},
{
"db_name": "UMLS",
"db_id": "C0002921"
}
]
},
{
"id": "DerAnaesthesist.70460588.eng.abstr-s1-t7",
"type": "umlsterm",
"text": [
"nerve conduction"
],
"offsets": [
[
72,
88
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0027788"
}
]
},
{
"id": "DerAnaesthesist.70460588.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"measure"
],
"offsets": [
[
270,
277
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0079809"
}
]
},
{
"id": "DerAnaesthesist.70460588.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"drug"
],
"offsets": [
[
281,
285
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0013227"
}
]
},
{
"id": "DerAnaesthesist.70460588.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"concentration"
],
"offsets": [
[
330,
343
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0086045"
}
]
},
{
"id": "DerAnaesthesist.70460588.eng.abstr-s2-t4",
"type": "umlsterm",
"text": [
"bupivacaine"
],
"offsets": [
[
354,
365
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0006400"
}
]
},
{
"id": "DerAnaesthesist.70460588.eng.abstr-s2-t5",
"type": "umlsterm",
"text": [
"rabbit"
],
"offsets": [
[
369,
375
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0034493"
}
]
},
{
"id": "DerAnaesthesist.70460588.eng.abstr-s2-t6",
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] |
DerAnaesthesist.70460592.eng.abstr
|
DerAnaesthesist.70460592.eng.abstr
|
[
{
"id": "DerAnaesthesist.70460592.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Aim : The aim of this study was to investigate whether the plasma levels of the circulating adhesion molecules sICAM-1 and sE-selectin could serve as early predictors of developing sepsis and its severity ."
],
"offsets": [
[
0,
206
]
]
}
] |
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13
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{
"id": "DerAnaesthesist.70460592.eng.abstr-s1-t2",
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[] |
[] |
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DerAnaesthesist.70460599.eng.abstr
|
DerAnaesthesist.70460599.eng.abstr
|
[
{
"id": "DerAnaesthesist.70460599.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Reproduction of an ancient Egyptian mouth-opening device raises certain technological and historical questions . The most effective variation has proven to be a device made of strip iron built exactly according to the proportions given in the Hunefer papyrus . This device allows quick and safe intubation of intubation dummy CLA 8 without a supplementary light source . Originally , the device was a metal instrument made of meteoric iron , apparently produced only in small numbers . To date , the form of production remains a mystery , since the smelting and processing of iron was totally uncommon in ancient Egypt . Based on the material structure of the device and certain portrayals in graves in Deir el-Medina , mouth-opening as it was actually performed reveals a methodology that can be reconciled with modern pre-clinical polytrauma management . In principle , this indicates that the introduction of artificial respiration thousands of years ago would have been possible ."
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0,
984
]
]
}
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{
"id": "DerAnaesthesist.70460599.eng.abstr-s6-t2",
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773,
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},
{
"id": "DerAnaesthesist.70460599.eng.abstr-s6-t3",
"type": "umlsterm",
"text": [
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833,
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},
{
"id": "DerAnaesthesist.70460599.eng.abstr-s7-t1",
"type": "umlsterm",
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[] |
[] |
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},
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"id": "DerAnaesthesist.70460599.eng.abstr-s6-r1-t1.1-t3.1",
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},
{
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{
"id": "DerAnaesthesist.70460599.eng.abstr-s7-r2-t2.1-t1.2",
"type": "affects",
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{
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DerAnaesthesist.70460613.eng.abstr
|
DerAnaesthesist.70460613.eng.abstr
|
[
{
"id": "DerAnaesthesist.70460613.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The PhysioFlex anaesthesia machine is designed to operate as a quantitative closed system . The gas in the system is circulated at 70 litres per minute . With its small soda lime canister and the integration of all components in a thermal insulating case it fulfils all prerequisites for excellent climatisation of the anaesthetic gases . The extent of warming and humidifying of the anaesthetic gases was monitored during extended neurosurgical operations using long tubes to the patient ( 3 m each ) in an cold operating room ( 17-18 °C)."
],
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[
0,
540
]
]
}
] |
[
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{
"id": "DerAnaesthesist.70460613.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"lime"
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{
"id": "DerAnaesthesist.70460613.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"anaesthetic"
],
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319,
330
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[] |
[] |
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}
] |
DerAnaesthesist.70460616.eng.abstr
|
DerAnaesthesist.70460616.eng.abstr
|
[
{
"id": "DerAnaesthesist.70460616.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Continuous spinal anaesthesia ( CSA ) is a further means of central nerve block for anaesthesia besides single-shot spinal ( SSS ) , combined spinal/epidural , and epidural anaesthesia ."
],
"offsets": [
[
0,
186
]
]
}
] |
[
{
"id": "DerAnaesthesist.70460616.eng.abstr-s1-t1",
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"nerve"
],
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[
68,
73
]
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{
"id": "DerAnaesthesist.70460616.eng.abstr-s1-t2",
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104,
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"id": "DerAnaesthesist.70460616.eng.abstr-s1-t3",
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],
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11,
29
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{
"id": "DerAnaesthesist.70460616.eng.abstr-s1-t4",
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68,
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{
"id": "DerAnaesthesist.70460616.eng.abstr-s1-t5",
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164,
184
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],
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"db_name": "UMLS",
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] |
[] |
[] |
[
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"id": "DerAnaesthesist.70460616.eng.abstr-s1-r2-t1.1-t4.1",
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"id": "DerAnaesthesist.70460616.eng.abstr-s1-r9-t2.1-t5.1",
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DerAnaesthesist.70460622.eng.abstr
|
DerAnaesthesist.70460622.eng.abstr
|
[
{
"id": "DerAnaesthesist.70460622.eng.abstr-passage-0",
"type": "abstract",
"text": [
"S-Ropivacaine is a new , long-acting amide local anaesthetic . It is the first local anaesthetic to be on the market as a single isomer . Its pharmacodynamic and pharmacokinetic profile is similar to that of bupivacaine . In vitro and in vivo experiments have shown ropivacaine to be less cardiotoxic than bupivacaine . When given epidurally , both local anaesthetics are equally effective in producing sensory block , but motor block seems to be less pronounced in the case of ropivacaine ."
],
"offsets": [
[
0,
491
]
]
}
] |
[
{
"id": "DerAnaesthesist.70460622.eng.abstr-s1-t1",
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"amide"
],
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"id": "DerAnaesthesist.70460622.eng.abstr-s1-t2",
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"id": "DerAnaesthesist.70460622.eng.abstr-s1-t3",
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"local anaesthetic"
],
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43,
60
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{
"id": "DerAnaesthesist.70460622.eng.abstr-s2-t1",
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85,
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"id": "DerAnaesthesist.70460622.eng.abstr-s2-t2",
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110,
116
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{
"id": "DerAnaesthesist.70460622.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
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[
122,
128
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"db_id": "C0087136"
}
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},
{
"id": "DerAnaesthesist.70460622.eng.abstr-s2-t4",
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"text": [
"isomer"
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129,
135
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79,
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]
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162,
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"local anaesthetics"
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]
}
] |
[] |
[] |
[
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] |
DerAnaesthesist.70460659.eng.abstr
|
DerAnaesthesist.70460659.eng.abstr
|
[
{
"id": "DerAnaesthesist.70460659.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Due to its important physiological and pathophysiological actions , the pluripotent signaling molecule nitric oxide ( NO ) is increasingly of interest in clinical medicine . Despite increasing use by anaesthetists in inhalational therapy for intensive care patients with respiratory distress syndrome , the potential interactions of anaesthetic agents and NO have thus far received little attention . The literature available to date on this topic is somewhat controversial , and highlights the need for additional research in this area . This review summarises the pertinent literature in this area for the anaesthetist and describes potential mechanisms by which anaesthetics may interfere with the synthesis and/or effects of NO in the human body ."
],
"offsets": [
[
0,
751
]
]
}
] |
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"id": "DerAnaesthesist.70460659.eng.abstr-s4-t4",
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"id": "DerAnaesthesist.70460659.eng.abstr-s4-t5",
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}
] |
[] |
[] |
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DerAnaesthesist.70460683.eng.abstr
|
DerAnaesthesist.70460683.eng.abstr
|
[
{
"id": "DerAnaesthesist.70460683.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Objective : The data of 60 postoperatively sedated and ventilated patients were studied for analysis of oesophageal , bladder , and rectal temperatures . The purpose of the investigation was to clarify whether changes of oesophageal temperature are adequately reflected by bladder and rectal temperatures and whether the rate of rewarming has an influence on the accuracy of the latter two sites ."
],
"offsets": [
[
0,
397
]
]
}
] |
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"id": "DerAnaesthesist.70460683.eng.abstr-s2-t1",
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{
"id": "DerAnaesthesist.70460683.eng.abstr-s2-t4",
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] |
[] |
[] |
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] |
DerAnaesthesist.70460689.eng.abstr
|
DerAnaesthesist.70460689.eng.abstr
|
[
{
"id": "DerAnaesthesist.70460689.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Two groups of 15 patients each with disseminated intravascular coagulation in association with septic disease were treated with low-molecular-weight heparin ( lmw-heparin ) in different dosages ( group I : 1,5-5 IE/kg body weight ( BW ) per hour ; group II : 8-15 IE/kg BW ) . We studied the levels of D-dimer , thrombin-antithrombin III complex ( TAT ) , prothrombin fragments 1 and 2 ( PTF ) , and global tests of coagulation like prothrombin time ( PT ) , activated partial thromboplastin time ( PTT ) , thrombin time ( TT ) and platelet count , plasminogen activation ( PA ) and fibrinogen concentration to estimate the success of heparin therapy in the two groups . TT and fibrinogen concentration were not suitable to follow the course of the coagulation disorder . PT , PTT , platelet count progressively PA , D-dimer , TAT , and PTF normalised progressively after heparinisation . However , only the last three parameters were sensitive enough to show different effects of variable dosages of lmw-heparin . D-dimer , TAT , and PTF levels declined in proportion with heparin concentrations , and thus appear to be the most useful parameters for monitoring the therapeutic effect of heparin in septic coagulopathies ."
],
"offsets": [
[
0,
1223
]
]
}
] |
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DerAnaesthesist.70460697.eng.abstr
|
DerAnaesthesist.70460697.eng.abstr
|
[
{
"id": "DerAnaesthesist.70460697.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The increased consumption of \" ecstasy \" ( MDMA , 3,4-methylenedioxy-methamphetamine) has also increased the number of life-threatening intoxications . From a Medline search of the years 1992-1996 , reports were registered and evaluated . Besides cerebral , cardiorespiratory , renal , and hepatic symptoms , hyperthermia syndromes such as malignant hyperthermia , neuroleptic malignant syndrome , or the serotonin syndrome were common . In addition to a discussion of the intoxication symptoms and their acute and intensive-care therapy , the psychological and physiological effects of \" ecstasy \" will be described . Some historical considerations of the topic are included in this review ."
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692
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}
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[] |
[] |
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] |
DerAnaesthesist.70460715.eng.abstr
|
DerAnaesthesist.70460715.eng.abstr
|
[
{
"id": "DerAnaesthesist.70460715.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Objectives : This study was conducted to evaluate a modified technique of interskalene brachial plexus anaesthesia ( ISB ) and postoperative catheter analgesia for shoulder surgery . The original method described by Winnie bears some rare but life-threatening complications ( inadvertent subarachnoid or intra-arterial injection , pneumothorax ) ."
],
"offsets": [
[
0,
347
]
]
}
] |
[
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"id": "DerAnaesthesist.70460715.eng.abstr-s1-t2",
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127,
140
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},
{
"id": "DerAnaesthesist.70460715.eng.abstr-s1-t4",
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"id": "DerAnaesthesist.70460715.eng.abstr-s1-t5",
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{
"id": "DerAnaesthesist.70460715.eng.abstr-s1-t6",
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172
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[] |
[] |
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DerAnaesthesist.70460751.eng.abstr
|
DerAnaesthesist.70460751.eng.abstr
|
[
{
"id": "DerAnaesthesist.70460751.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Thoracic epidural anaesthesia ( TEA ) faces growing interest as an adjuvant anaesthetic and postoperative analgesic regimen . The procedure allows a specific blockade of nociceptive reflex arches and may exert beneficial effects on stress-induced alterations of organ function . Myocardial blood flow to areas at risk is improved , and paradoxical reactions of atherosclerotic coronary arteries after sympathetic stimulation are suppressed . After cardiac surgery , TEA improved postoperative recovery and resulted in better haemodynamic stability and allowed earlier extubation . During vascular surgery , the graft occlusion rate was significantly decreased . The improved pulmonary function after TEA is due to superior pain relief which allows the patients to breathe and cough sufficiently . After upper abdominal surgery , TEA leads to improved recovery of gastrointestinal function which reduces the risk of bacterial translocation . Although lumbar epidural anaesthesia is preferred by many anaesthesiologists as there is no risk of traumatizing the spinal cord , many positive effects are forgone . With insufficient rostral spread of a lumbar epidural block above the fifth thoracic level , cardiac complications can occur due to reflex activation of sympathetic outflow in unblocked thoracic regions . When the contraindications are carefully observed , TEA can be safely performed in most patients ."
],
"offsets": [
[
0,
1411
]
]
}
] |
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{
"id": "DerAnaesthesist.70460751.eng.abstr-s4-t2",
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DerAnaesthesist.70460771.eng.abstr
|
DerAnaesthesist.70460771.eng.abstr
|
[
{
"id": "DerAnaesthesist.70460771.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Objective : To study the influence of dopexamine on pulmonary shunt and hypoxic pulmonary vasoconstriction during major thoracic surgery with one-lung ventilation ( OLV ) . Design : Prospective , randomised , placebo-controlled study . Setting : University hospital . Patients : Twenty adult patients undergoing elective pulmonary resection . Anaesthesia : General anaesthesia was performed using propofol , fentanyl , N2O and vecuronium . Volume-controlled ventilation was performed to maintain normocapnia over the whole investigation period . During OLV , the tidal volume was reduced and the respiratory rate was increased to avoid a peak airway pressure exceeding 40 cm H2O. Furthermore the FiO2 was increased to 1,0 and the external PEEP was removed during OLV . Interventions : The patients received either dopexamine at 2 µg/kg/min ( group A , n=10) or 0,9% saline as control ( group B , n=10) after assessing the baseline values . Measurement and results : The following cardiorespiratory variables were recorded : Heart rate , mean arterial pressure and mean pulmonary arterial pressure . Cardiac output was measured by thermodilution using a continuous cardiac output thermodilution catheter . Arterial and mixed venous blood gas analysis were measured from simultaneously drawn samples . Cardiac index ( CI ) , systemic vascular resistance index , pulmonary vascular resistance index , oxygen delivery index ( DO2I), oxygen consumption index and the venous admixture were calculated using standard formula . Furthermore , pressure-flow-curves were constructed to analyse flow independent changes in the pulmonary vascular resistance . Data were recorded at the following times : After induction of anaesthesia in stable haemodynamics during two-lung ventilation ( baseline values , T0), intraoperatively during one-lung ventilation ( T1) and postoperatively after re-establishing two-lung ventilation ( T2). Patients characteristics , data from the preoperative lung function testing and surgical procedures did not differ significantly between the groups . CI increased in the dopexamine group from 2,5 +/- 1,2 l - min-1 - m-2 ( T0) to 3,6 +/- 0,9 l - min-1 - m-2 ( T1) and 4,0 +/- 1,3 l - min-1 - m-2 ( T2). The course of the intrapulmonary right-to-left shunting did not differ between the groups . In the dopexamine-treated group the DO2I increased from 430 +/- 143 ml - min - m-2 ( T0) to 652 +/- 255 ml - min - m-2 ( T1) and 653 +/- 207 ml - min - m-2 ( T2). Regarding the pressure-flow-curves there was no difference during OLV between the two groups indicating no major blocking effect of dopexamine on hypoxic pulmonary vasoconstriction . Conclusion : It is concluded that dopexamine can be used to improve haemodynamics and oxygen delivery during thoracic surgery without increasing venous admixture during one-lung ventilation ."
],
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0,
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[] |
[] |
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] |
DerAnaesthesist.70460776.eng.abstr
|
DerAnaesthesist.70460776.eng.abstr
|
[
{
"id": "DerAnaesthesist.70460776.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The objective of this prospective , randomised study was to investigate the incidence of postoperative nausea and/or vomiting ( PONV ) during the first 24 h postoperatively . For a quality assurance study on PONV , we compared two established general anaesthetic procedures in 239 patients undergoing four different types of surgery ( subtotal thyroidectomy , laparotomy for gynaecological procedures , laparoscopy , and surgery for extra-abdominal procedures ) ."
],
"offsets": [
[
0,
463
]
]
}
] |
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DerAnaesthesist.70460783.eng.abstr
|
DerAnaesthesist.70460783.eng.abstr
|
[
{
"id": "DerAnaesthesist.70460783.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Pheochromocytomas are functionally active , catecholamine-secreting tumours of chromaffin tissue . The mainstay of pharmacological therapy is preoperative treatment with oral phenoxybenzamine . This drug irreversibly alkylates alpha-1-adrenergic receptors on vascular smooth muscle and renders them nonfunctional , thereby causing vasodilatation . The duration of action of a single dose is approximately 24 h . Therefore , postoperative hypotension is a hazard of therapy with phenoxybenzamine if adequate plasma volume repletion is not provided . Prazosin , a short-acting , competitive alpha-1 blocker , has been used preoperatively , but has been criticized for its failure to adequately prevent perioperative hypertensive episodes ."
],
"offsets": [
[
0,
737
]
]
}
] |
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0,
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75
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],
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"id": "DerAnaesthesist.70460783.eng.abstr-s1-t3",
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],
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]
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}
] |
[] |
[] |
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DerAnaesthesist.70460801.eng.abstr
|
DerAnaesthesist.70460801.eng.abstr
|
[
{
"id": "DerAnaesthesist.70460801.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Unnoticed , minor damage to the unidirectional respiratory valves of the Draeger respiratory circuit may lead to intermittent and unpredictable malfunction , resulting in rebreathing and hypercapnia . The damage may be so minor that normal visual and functional test routines may be insufficient to detect it . We report one case of a potential life-threatening malfunction of the inspiratory valve and also propose economical solutions utilizing altered construction , modified machine-check procedures , or a simple instrument that adds only one step to the machine-check procedure . The general problem of minor but functionally important damage to parts of ventilatory equipment - so-called borderline damage - may not be limited to this particular model or manufacturer . Most users of ventilatory equipment believe that equipment that goes through normal check procedures is either fully functional or non-functional . In reality , this is not the case . Intermittent malfunctions due to slightly damaged equipment may be missed with normal machine-check procedures . This problem results in a significant but incalculable increased in risk to patients . Because of unclear reproduceability of intermittent malfunctions caused by borderline damage , there also is an increased forensic risk for the anaesthesiologist . The risk of mechanical malfunction might be displaced by software problems in new-generation ventilators in the market ."
],
"offsets": [
[
0,
1445
]
]
}
] |
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[] |
[] |
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DerAnaesthesist.70460829.eng.abstr
|
DerAnaesthesist.70460829.eng.abstr
|
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{
"id": "DerAnaesthesist.70460829.eng.abstr-passage-0",
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"text": [
"The extent of myocardial damage occurring during acute myocardial infarction is time dependent , and there is abundant evidence from most clinical trials that mortality reduction is greatest in patients treated early with thrombolytic agents , although beneficial effects have been shown with treatment initiated up to 12 h after onset of symptoms . All studies on prehospital thrombolysis have conclusively shown the practicability and safety of patient selection and administration of the thrombolytic agent . The accuracy of diagnosis in the prehospital setting was comparable to trials of in-hospital thrombolysis , e.g. , in the Myocardial Infarction Triage and Intervention Project ( MITI ) 98% of the patients enrolled had subsequent evidence of acute myocardial infarction . With regard to time savings , all randomized studies showed positive results . The smallest time gain was observed in the MITI trial : prehospital-treated patients received thrombolytic therapy an average of 33 min earlier than those treated in hospital . In the European Myocardial Infarction Project ( EMIP ) the difference in time between prehospital and hospital treatment was a median of 55 min . However , none of these trials was able to show a significant short-term mortality difference between the two groups . Only a meta analysis of five randomized studies with a combined median time gain of about 60 min showed a significant 17% reduction in short-term mortality for patients who received thrombolytic therapy in the prehospital phase . In the Grampian Region Early Anistreplase Trial ( GREAT ) , a study performed in a more rural area than other studies , the time gain by prehospital initiation of thrombolysis was a median of 130 min . GREAT was the only study to date reporting a significant mortality benefit for prehospital-treated patients after 3 months and 1 year . In conclusion , prehospital thrombolysis is feasible and safe . Patients with acute myocardial infarction can be correctly identified and treated with thrombolytic agents in the prehospital setting with the same rate of complications as expected for in-hospital thrombolysis , provided basic resuscitation equipment including a defibrillator is available . The results of randomized studies comparing the results of prehospital and in-hospital thrombolysis seem to justify the prehospital institution of thrombolytic therapy , especially in rural areas where transport times to the hospital are long and the expected time gain is largest . The choice of the thrombolytic agent seems to be of minor importance and should follow prehospital practicability ( bolus injection ) and costs . Aspirin should be given to all prehospital patients with suspected myocardial infarction regardless of thrombolytic therapy ."
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] |
DerAnaesthesist.70460850.eng.abstr
|
DerAnaesthesist.70460850.eng.abstr
|
[
{
"id": "DerAnaesthesist.70460850.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Anxiolysis with drugs and psychoprophylaxis are both recognised methods of preoperative preparation . The beneficial effects of anxiolytics , however , appear to be difficult to prove . In this study a comparison was made of heart rate ( HR ) , blood pressure ( BP ) , and norepinephrine , epinephrine , and cortisol levels . In group I 19 children recieved only psychological treatment , while in group II 21 children received 0.2 mg/kg midazolam orally . Measuring points were directly before medication , 30 min afterward , and at induction of anaesthesia . During the observation period the patients ( 5-10 years old ) remained calm . At the beginning of the study the parameters of all patients were within a normal range ; 30 min after premedication the HR and BP were significantly higher in group I than in group II . In contrast to group I , epinephrine levels in group II were lower at the beginning of anaesthesia than before premedication . In both groups , norepinephrine levels were the same at induction of anaesthesia as before premedication . Cortisol decreased only in patients who received midazolam . HR , BP , as well as humoral stress parameters indicate that midazolam in a dose of 0.2 mg/kg orally is sufficient to reduce preoperative stress in children ."
],
"offsets": [
[
0,
1279
]
]
}
] |
[
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"drugs"
],
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[
16,
21
]
],
"normalized": [
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"db_name": "UMLS",
"db_id": "C0013227"
}
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},
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"id": "DerAnaesthesist.70460850.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"psychoprophylaxis"
],
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[
26,
43
]
],
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"db_id": "C0033107"
}
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},
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"id": "DerAnaesthesist.70460850.eng.abstr-s1-t3",
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"methods"
],
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[
64,
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{
"id": "DerAnaesthesist.70460850.eng.abstr-s2-t1",
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"anxiolytics"
],
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[
128,
139
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],
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}
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},
{
"id": "DerAnaesthesist.70460850.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"heart"
],
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[
225,
230
]
],
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{
"id": "DerAnaesthesist.70460850.eng.abstr-s3-t2",
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{
"db_name": "UMLS",
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}
]
},
{
"id": "DerAnaesthesist.70460850.eng.abstr-s3-t3",
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"text": [
"pressure"
],
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251,
259
]
],
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{
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"db_id": "C0033095"
}
]
},
{
"id": "DerAnaesthesist.70460850.eng.abstr-s3-t4",
"type": "umlsterm",
"text": [
"norepinephrine"
],
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[
273,
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]
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] |
DerAnaesthesist.70460856.eng.abstr
|
DerAnaesthesist.70460856.eng.abstr
|
[
{
"id": "DerAnaesthesist.70460856.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Today , noise pollution is an evident and ubiquitous problem even in intensive care units . Noise can disturb the physiological and psychological balance in patients and staff . Especially intubated patients and those breathing spontaneously through a T-piece are exposed to the noise emitted by the nebuliser used to humidity the respiratory gas . This may make patients feel uncomfortable . To reduce noise pollution in the ICU a modified T-piece has been developed and investigated . In order to heat and humidity the respiratory gas a Conchaterm III unit ( Kendall company ) and a thermo flow cylinder ( De Vilbiss company ) is necessary . While respiratory gas is flowing , water is sucked out of the heated thermoflow cylinder and nebulised according to the Venturi-Bernoulli principle . To adjust the oxygen concentration of the respiratory gas a plastic ring must be turned to either close ( 98% oxygen ) or open a valve allowing room air to mix ( 40% oxygen ) . Noise pollution of the unit varies with admixture of room air . With a new device - a special oxygen - air mixing chamber - the oxygen concentration of the respiratory gas can be adjusted outside the thermoflow cylinder , hardly producing any noise pollution . Therefore the principle of nebulisation could be changed to humidification . A thermoflow cylinder without the nebulisation unit allows the respiratory gas to flow through the thermoflow cylinder over heated and evaporating water , hardly causing any noise pollution . In both types of T-pieces the temperature of the respiratory gas is controlled and corrected by the Conchaterm unit . As the result of these modifications , noise pollution has been reduced from 70 dB ( A ) to 55 dB ( A ) . In the modified T-piece , the quality of humidification has been evaluated with a fresh gas flow of 22 l/min and at a gas temperature of 37 ° C , not only collecting condensed water but also lost water . The modified T-piece allows a physiological humidification of the respiratory gas . The modified T-piece is a simple and efficacious substitute . Patients and staff are protected from adverse noise effects and patient well-being might be improved ."
],
"offsets": [
[
0,
2177
]
]
}
] |
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] |
DerAnaesthesist.70460860.eng.abstr
|
DerAnaesthesist.70460860.eng.abstr
|
[
{
"id": "DerAnaesthesist.70460860.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Post-dural puncture headache ( PDPH ) is a significant complication of spinal anaesthesia . Diameter and tip of the needle as well as the patient's age have been proven to be important determinants . The question of whether post-operative recumbency can reduce the risk of PDPH has not been answered uniformly . And besides , some studies referring to this subject reveal methodical failures , for example , as to clear definition and exact documentation of post-operative immobilization . Furthermore , fine-gauge needles ( 26G or more ) have not been investigated yet . The first aim of our study was therefore to examine the role of recumbency in the prevention of PDPH under controlled conditions using thin needles . Secondly , we wanted to confirm the reported prophylactic effect of needles with a modified , atraumatic tip ( Whitacre and Atraucan ) by comparing them to Quincke needles of identical diameter . Most of the former investigators compared Quincke with atraumatic needles of different size regardless of the known influence of the diameter on PDPH ."
],
"offsets": [
[
0,
1069
]
]
}
] |
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],
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11,
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]
],
"normalized": [
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}
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},
{
"id": "DerAnaesthesist.70460860.eng.abstr-s1-t2",
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"text": [
"headache"
],
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20,
28
]
],
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"db_id": "C0018681"
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},
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"id": "DerAnaesthesist.70460860.eng.abstr-s1-t3",
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"complication"
],
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55,
67
]
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"id": "DerAnaesthesist.70460860.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"spinal anaesthesia"
],
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71,
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},
{
"id": "DerAnaesthesist.70460860.eng.abstr-s2-t1",
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"text": [
"tip"
],
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105,
108
]
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{
"id": "DerAnaesthesist.70460860.eng.abstr-s2-t2",
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{
"id": "DerAnaesthesist.70460860.eng.abstr-s2-t3",
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"text": [
"age"
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148,
151
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]
},
{
"id": "DerAnaesthesist.70460860.eng.abstr-s2-t4",
"type": "umlsterm",
"text": [
"proven"
],
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162,
168
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},
{
"id": "DerAnaesthesist.70460860.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"risk"
],
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265,
269
]
],
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],
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272
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"id": "DerAnaesthesist.70460860.eng.abstr-s4-t1",
"type": "umlsterm",
"text": [
"exact"
],
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DerAnaesthesist.70460867.eng.abstr
|
DerAnaesthesist.70460867.eng.abstr
|
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"id": "DerAnaesthesist.70460867.eng.abstr-s2-r16-t2.1-t1.1",
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] |
DerAnaesthesist.70460890.eng.abstr
|
DerAnaesthesist.70460890.eng.abstr
|
[
{
"id": "DerAnaesthesist.70460890.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A healthy 38-year-old woman suffered a sudden cardiac arrest 2 days after a vaginal hysterectomy . Although standard cardiac life support ( CPR ) was instituted immediately after the event , it was not possible to re-establish a spontaneous circulation for about 40 min . Systemic intravenous thrombolytic therapy with slow injection of 1.5 million IU urokinase was performed as a final life-maintaining measure because of the high probability that the underlying cause was a pulmonary embolus ; 10 min later ( after 60 min of ongoing CPR ) the patient regained a stable circulation . She survived without neurological deficit in spite of the long duration of CPR ."
],
"offsets": [
[
0,
665
]
]
}
] |
[
{
"id": "DerAnaesthesist.70460890.eng.abstr-s1-t1",
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"woman"
],
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22,
27
]
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{
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"db_id": "C0043210"
}
]
},
{
"id": "DerAnaesthesist.70460890.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"hysterectomy"
],
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84,
96
]
],
"normalized": [
{
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"db_id": "C0020699"
}
]
},
{
"id": "DerAnaesthesist.70460890.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"cardiac arrest"
],
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[
46,
60
]
],
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"db_id": "C0018790"
}
]
},
{
"id": "DerAnaesthesist.70460890.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"vaginal hysterectomy"
],
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[
76,
96
]
],
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{
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"db_id": "C0020700"
}
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},
{
"id": "DerAnaesthesist.70460890.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"standard"
],
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[
108,
116
]
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{
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"db_id": "C0038137"
},
{
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"db_id": "C0175675"
}
]
},
{
"id": "DerAnaesthesist.70460890.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"life"
],
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[
125,
129
]
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{
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"db_id": "C0376558"
}
]
},
{
"id": "DerAnaesthesist.70460890.eng.abstr-s2-t3",
"type": "umlsterm",
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"CPR"
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140,
143
]
],
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"db_id": "C0007203"
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]
},
{
"id": "DerAnaesthesist.70460890.eng.abstr-s2-t4",
"type": "umlsterm",
"text": [
"circulation"
],
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241,
252
]
],
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{
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}
]
},
{
"id": "DerAnaesthesist.70460890.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"thrombolytic"
],
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[
293,
305
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0016018"
}
]
},
{
"id": "DerAnaesthesist.70460890.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"therapy"
],
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[
306,
313
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0087111"
},
{
"db_name": "UMLS",
"db_id": "C0039798"
}
]
},
{
"id": "DerAnaesthesist.70460890.eng.abstr-s3-t3",
"type": "umlsterm",
"text": [
"injection"
],
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[
324,
333
]
],
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{
"db_name": "UMLS",
"db_id": "C0021485"
}
]
},
{
"id": "DerAnaesthesist.70460890.eng.abstr-s3-t4",
"type": "umlsterm",
"text": [
"urokinase"
],
"offsets": [
[
352,
361
]
],
"normalized": [
{
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"db_id": "C0042071"
}
]
},
{
"id": "DerAnaesthesist.70460890.eng.abstr-s3-t5",
"type": "umlsterm",
"text": [
"measure"
],
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[
404,
411
]
],
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"db_id": "C0079809"
}
]
},
{
"id": "DerAnaesthesist.70460890.eng.abstr-s3-t6",
"type": "umlsterm",
"text": [
"probability"
],
"offsets": [
[
432,
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]
],
"normalized": [
{
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"db_id": "C0033204"
}
]
},
{
"id": "DerAnaesthesist.70460890.eng.abstr-s3-t7",
"type": "umlsterm",
"text": [
"cause"
],
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[
464,
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],
"normalized": [
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"db_id": "C0015127"
}
]
},
{
"id": "DerAnaesthesist.70460890.eng.abstr-s3-t8",
"type": "umlsterm",
"text": [
"embolus"
],
"offsets": [
[
486,
493
]
],
"normalized": [
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"db_name": "UMLS",
"db_id": "C0013932"
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]
},
{
"id": "DerAnaesthesist.70460890.eng.abstr-s3-t9",
"type": "umlsterm",
"text": [
"CPR"
],
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535,
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},
{
"id": "DerAnaesthesist.70460890.eng.abstr-s3-t10",
"type": "umlsterm",
"text": [
"patient"
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],
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"db_id": "C0030705"
}
]
},
{
"id": "DerAnaesthesist.70460890.eng.abstr-s3-t11",
"type": "umlsterm",
"text": [
"circulation"
],
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571,
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],
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]
},
{
"id": "DerAnaesthesist.70460890.eng.abstr-s3-t12",
"type": "umlsterm",
"text": [
"thrombolytic therapy"
],
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[
293,
313
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],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0040044"
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]
},
{
"id": "DerAnaesthesist.70460890.eng.abstr-s3-t13",
"type": "umlsterm",
"text": [
"pulmonary embolus"
],
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[
476,
493
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0034065"
}
]
},
{
"id": "DerAnaesthesist.70460890.eng.abstr-s4-t1",
"type": "umlsterm",
"text": [
"CPR"
],
"offsets": [
[
660,
663
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0007203"
}
]
}
] |
[] |
[] |
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{
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{
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] |
DerAnaesthesist.70460915.eng.abstr
|
DerAnaesthesist.70460915.eng.abstr
|
[
{
"id": "DerAnaesthesist.70460915.eng.abstr-passage-0",
"type": "abstract",
"text": [
"For ethical and socio-economical reasons ( cost-explosion in transfusion-medicine , patient's individual destiny ) , devepolment and consistent application of allogeneic transfusion sparing techniques in surgery is a chal- lenge to anesthesiologists , surgeons and blood-bankers . The combination of different techniques , i.e. autologous predonation , hemodilution , choice of anesthetic regimen , deliberate hypotension , application of anti-fibrinolytic agents and autotransfusion of intraoperatively saved blood allow for avoidance of allogeneic blood transfusion even in patients presenting important intraoperative hemorrhage ."
],
"offsets": [
[
0,
633
]
]
}
] |
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43,
57
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{
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{
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]
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{
"id": "DerAnaesthesist.70460915.eng.abstr-s1-t6",
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{
"id": "DerAnaesthesist.70460915.eng.abstr-s2-t2",
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"hemodilution"
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353,
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},
{
"id": "DerAnaesthesist.70460915.eng.abstr-s2-t3",
"type": "umlsterm",
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"choice"
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"id": "DerAnaesthesist.70460915.eng.abstr-s2-t4",
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"anesthetic"
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{
"id": "DerAnaesthesist.70460915.eng.abstr-s2-t5",
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"id": "DerAnaesthesist.70460915.eng.abstr-s2-t6",
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"id": "DerAnaesthesist.70460915.eng.abstr-s2-t7",
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"blood"
],
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{
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{
"id": "DerAnaesthesist.70460915.eng.abstr-s2-t11",
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{
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"db_id": "C0005841"
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]
}
] |
[] |
[] |
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DerAnaesthesist.70460938.eng.abstr
|
DerAnaesthesist.70460938.eng.abstr
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[] |
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DerAnaesthesist.70460943.eng.abstr
|
DerAnaesthesist.70460943.eng.abstr
|
[
{
"id": "DerAnaesthesist.70460943.eng.abstr-passage-0",
"type": "abstract",
"text": [
"In an investigation of infection control methods for respirator systems in 89 randomly selected German intensive care units as a part of the NIDEP study ( Nosocomial Infections in Germany - Surveillance and Prevention ) , it was found that respirator systems were exchanged daily in about 50% of the intensive care units . However , Craven et al. found that changing circuits ( including tubing and exhalation valve and the attached humidifier ) every 24 h rather than every 48 h was independently associated with the occurrence of nosocomial pneumonia . On the basis of these results and recent studies , the current situation in the literature was analyzed in order to make recommendations for exchanging ventilator circuits ."
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"offsets": [
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0,
728
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]
}
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[
{
"id": "DerAnaesthesist.70460943.eng.abstr-s1-t1",
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"methods"
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"id": "DerAnaesthesist.70460943.eng.abstr-s1-t4",
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"id": "DerAnaesthesist.70460943.eng.abstr-s1-t7",
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{
"id": "DerAnaesthesist.70460943.eng.abstr-s1-t10",
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{
"id": "DerAnaesthesist.70460943.eng.abstr-s1-t12",
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"id": "DerAnaesthesist.70460943.eng.abstr-s1-t16",
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"id": "DerAnaesthesist.70460943.eng.abstr-s2-t1",
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"id": "DerAnaesthesist.70460943.eng.abstr-s3-t1",
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"id": "DerAnaesthesist.70460943.eng.abstr-s3-t2",
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{
"id": "DerAnaesthesist.70460943.eng.abstr-s3-t3",
"type": "umlsterm",
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"normalized": [
{
"db_name": "UMLS",
"db_id": "C0087153"
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}
] |
[] |
[] |
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DerAnaesthesist.70460949.eng.abstr
|
DerAnaesthesist.70460949.eng.abstr
|
[
{
"id": "DerAnaesthesist.70460949.eng.abstr-passage-0",
"type": "abstract",
"text": [
"In order to perform accurate low-flow anaesthesia ventilation , it is desirable to avoid the influence of fresh gas flow ( FGF ) and inspiration duration ( ID ) on the resulting minute volume ( MV ) . The Sulla 808V anaesthesia ventilator ( Draeger , Luebeck , Germany ) is originally not equipped with a fresh-gas decoupling ( FGD ) device . Therefore , changes of FGF and ID settings applied during controlled ventilation may lead to alterations of the resulting MV . Recently , a low-cost FGD device ( Carbamed , Bern-Liebefeld , Switzerland ) has been developed , which can be inserted into the circle system . We investigated the effect of this device on MV in the Sulla 808V anaesthesia apparatus ."
],
"offsets": [
[
0,
704
]
]
}
] |
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"id": "DerAnaesthesist.70460949.eng.abstr-s1-t2",
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"id": "DerAnaesthesist.70460949.eng.abstr-s1-t3",
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"FGF"
],
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123,
126
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"id": "DerAnaesthesist.70460949.eng.abstr-s2-t2",
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"id": "DerAnaesthesist.70460949.eng.abstr-s2-t4",
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{
"id": "DerAnaesthesist.70460949.eng.abstr-s3-t1",
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366,
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"id": "DerAnaesthesist.70460949.eng.abstr-s3-t2",
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"db_id": "C0243111"
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]
}
] |
[] |
[] |
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DerAnaesthesist.70460953.eng.abstr
|
DerAnaesthesist.70460953.eng.abstr
|
[
{
"id": "DerAnaesthesist.70460953.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Neurogenic pulmonary edema ( NPE ) is a rare but always life-threatening complication in patients with central nervous system lesions . NPE is evident if patients shortly after cerebral lesions suddenly develop pulmonary edema and other causes of the symptoms , such as aspiration of gastric content , congestive heart failiure and direct toxic exposure , are ruled out ."
],
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[
0,
371
]
]
}
] |
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{
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"id": "DerAnaesthesist.70460953.eng.abstr-s2-t3",
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"causes"
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"id": "DerAnaesthesist.70460953.eng.abstr-s2-t4",
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] |
[] |
[] |
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] |
DerAnaesthesist.70460964.eng.abstr
|
DerAnaesthesist.70460964.eng.abstr
|
[
{
"id": "DerAnaesthesist.70460964.eng.abstr-passage-0",
"type": "abstract",
"text": [
"We report the case of a 22-year-old woman who underwent two-step scoliosis surgery without allogeneic transfusion , although the intraoperative blood loss ( 3500 ml ) during the first procedure was higher than the calculated blood volume ( 3250 ml ) . Preoperatively the patient had donated four units of autologous blood . Intraoperatively blood-saving methods were combined . During the first operation acute normovolemic hemodilution ( target hemoglobin 9.0 g/dl ) was applied and during the second operation controlled hypotension ( systolic blood pressure 80 mmHg ) . Intraoperative autotransfusion was used in both procedures . During the first operation severe normovolemic anemia ( minimal hemoglobin 3.5 g/dl ) was accepted while the patient was ventilated with FiO2 1.0. The hemoglobin concentration was 8.6 g/dl after the first procedure and had increased to 11.6 g/dl 4 weeks after the second procedure . No severe complications occurred during the postoperative phase . This case report shows that also in surgical procedures with extreme blood loss any allogeneic transfusion can be avoided by the combination of blood-saving methods , acceptance of low intraoperative transfusion trigger and ventilation with 100% oxygen ."
],
"offsets": [
[
0,
1237
]
]
}
] |
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DerAnaesthesist.70460969.eng.abstr
|
DerAnaesthesist.70460969.eng.abstr
|
[
{
"id": "DerAnaesthesist.70460969.eng.abstr-passage-0",
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"text": [
"Wegener's granulomatosis is a distinct clinicopathologic entity characterized by granulomatous vasculitis of the upper and lower respiratory tract and glomerulonephritis . This disease can present as a clinical picture which resembles sepsis and adult respiratory distress syndrome ( ARDS ) . Wegener's disease requires immunosuppression which can have detrimental consequences when used in sepsis . The following case report illustrates the diagnostic difficulties encountered by intensiv care physicians treating severe pulmonary failure and multiple organ dysfunction in Wegener's granulomatosis appearing as ARDS with sepsis . Case report : A 19-year-old female patient had developed acute respiratory and renal failure after a prolonged period ( many months ) of antibiotic resistant otitis , sinusitis and mastoiditis . The patient had required intubation at another hospital and there was a history of tension pneumothorax and cardiopulmonary resuscitation during mechanical ventilation . Emergency extracorporeal membrane oxygenation ( ECMO ) for acute hypercapnic and hypoxic respiratory failure was instituted and the patient was transported to our institution while on ECMO . The patient was treated empirically for suspected pulmonary and systemic infection and received hydrocortisone ( 0,18 mg/kg/h ) as part of a protocol-driven treatment of septic shock in addition to antibiotic and antimycotic regime . The use of ECMO was required for 10 and mechanical ventilation for another 50 days after admission . After successfull extubation , central nervous system dysfunction became evident with a somnolent and generally unresponsive patient . When the hydrocortisone dose was gradually tapered , the clinical status of the patient further deteriorated , pulmonary gas exchange worsened and she developed renal failure with proteinura and hematuria . A renal biopsy was performed demonstrating vasculitis and focal segmental glomerulonephritis , a systemic granulomatous vasculitis was suspected ; the serum was tested for anti-proteinase 3 antibodies ( PR3-ANCA) and turned out to be positive ( 17.5 U/ml ; normal range 7 U/ml ) . The morphologic findings from renal biopsy , the positive test for antiproteinase 3 antibodies and the pulmonary-renal involvement with evidence of multisystem disease established the diagnosis of Wegener's granulomatosis . Immunosuppressive therapy with cyclophosphamide and prednisolon was instituted resulting in rapid improvement with recovery of pulmonary , renal and central nervous system function within two weeks . The use of ECMO in this patient served as a life - saving immediate measure usefull to \" buy time \" until a definite diagnosis could be established . ARDS represents an uniform pulmonary reaction to a large number of different noxious stimuli and disease entities . This case demonstrates that intensiv care physicians caring for critically ill patients with ARDS should include even rare causes of pulmonary injury into their differential diagnosis ."
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DerAnaesthesist.70460974.eng.abstr
|
DerAnaesthesist.70460974.eng.abstr
|
[
{
"id": "DerAnaesthesist.70460974.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Supported by two case reports we show that resistance to atracurium can develop postoperatively . Both patients had septic complications after elective thoracic surgery . A 39-year-old patient developed a bronchial fistula and a superinfection of the remaining thoracic cavity after pneumonectomy . At the time of rethoracotomy the neuromuscular blocking potency of atracurium had changed drastically : onset time was lengthened ( 7 vs. 3.5 min ) , recovery period ( DUR 10% ) was reduced ( 14 vs. 28 min ) and the maintenance dose had to be trippled ( 14.3 vs. 5.0 µg/kg per minute ) . Following superior lobe resection in a 56-year-old patient , middle lobe gangrene occurred which had to be removed . In contrast to the first anaesthesia the intubation dose of atracurium had to be increased significantly ( 70 vs. 40 mg ) , and even with this amount the neuromuscular blocking effect was not complete . Furthermore to accomplish a convenient state of relaxation the maintenance dose had to be raised considerably ( 11.8-16.5 vs. 5.5 µg/kg per minute ) . These reports show that even within a short period of time resistance to atracurium can develop and we must suppose that the severe inflammatory reactions caused these changes ."
],
"offsets": [
[
0,
1235
]
]
}
] |
[
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"text": [
"atracurium"
],
"offsets": [
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57,
67
]
],
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"db_id": "C0004234"
}
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},
{
"id": "DerAnaesthesist.70460974.eng.abstr-s1-t2",
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"case reports"
],
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29
]
],
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},
{
"id": "DerAnaesthesist.70460974.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"patients"
],
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103,
111
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},
{
"id": "DerAnaesthesist.70460974.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"complications"
],
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123,
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"id": "DerAnaesthesist.70460974.eng.abstr-s2-t3",
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"surgery"
],
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"db_id": "C0038894"
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{
"id": "DerAnaesthesist.70460974.eng.abstr-s2-t4",
"type": "umlsterm",
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{
"id": "DerAnaesthesist.70460974.eng.abstr-s3-t1",
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"text": [
"patient"
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185,
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},
{
"id": "DerAnaesthesist.70460974.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"fistula"
],
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[
215,
222
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0016169"
}
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},
{
"id": "DerAnaesthesist.70460974.eng.abstr-s3-t3",
"type": "umlsterm",
"text": [
"superinfection"
],
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229,
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],
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},
{
"id": "DerAnaesthesist.70460974.eng.abstr-s3-t4",
"type": "umlsterm",
"text": [
"pneumonectomy"
],
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283,
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],
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},
{
"id": "DerAnaesthesist.70460974.eng.abstr-s3-t5",
"type": "umlsterm",
"text": [
"bronchial fistula"
],
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[
205,
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],
"normalized": [
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},
{
"id": "DerAnaesthesist.70460974.eng.abstr-s4-t1",
"type": "umlsterm",
"text": [
"time"
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"normalized": [
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},
{
"id": "DerAnaesthesist.70460974.eng.abstr-s4-t2",
"type": "umlsterm",
"text": [
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],
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],
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},
{
"id": "DerAnaesthesist.70460974.eng.abstr-s4-t3",
"type": "umlsterm",
"text": [
"atracurium"
],
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366,
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],
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DerAnaesthesist.70461026.eng.abstr
|
DerAnaesthesist.70461026.eng.abstr
|
[
{
"id": "DerAnaesthesist.70461026.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The pharmacological profile of ketamine : Until recently , clinically available ketamine was a racemic mixture containing equal amounts of two enantiomers , ( S ) - and ( R ) -ketamine . The pharmacological profile of racemic ketamine is characterized by the socalled dissociative anesthesic state and profound sympathomimetic properties . Among the different sites of action , N-methyl-d-aspartate ( NMDA ) -receptor antagonism is considered to be the most important neuropharmacological mechanism of ketamine . Effects on opiate receptors , monoaminergic and cholinergic transmitters , and local anesthetic effects are obvious as well . Following intravenous administration , a rapid onset of action is seen within 1 min , lasting for about 10 min . The anaesthetic state is terminated due to redistribution , followed by hepatic and renal elimination with a half-life period of 2-3 h . For alternative administration , the intramuscular and oral route is also appropriate . The most important adverse effects are hallucinations and excessive increases in blood pressure and heart rate . These reactions can be attenuated or avoided by combining of ketamine with sedative or hypnotic drugs like midazolam and/or propofol . During controlled ventilation , increases in intracranial pressure are unlikely to occur ."
],
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[
0,
1315
]
]
}
] |
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] |
[] |
[] |
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},
{
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}
] |
DerAnaesthesist.70461050.eng.abstr
|
DerAnaesthesist.70461050.eng.abstr
|
[
{
"id": "DerAnaesthesist.70461050.eng.abstr-passage-0",
"type": "abstract",
"text": [
"We report two cases of unexpected courses of inhalation anaesthesia with sevoflurane and enflurane which were caused by the presence dry soda lime ."
],
"offsets": [
[
0,
148
]
]
}
] |
[
{
"id": "DerAnaesthesist.70461050.eng.abstr-s1-t1",
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"text": [
"inhalation"
],
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[
45,
55
]
],
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"db_id": "C0004048"
}
]
},
{
"id": "DerAnaesthesist.70461050.eng.abstr-s1-t2",
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"text": [
"sevoflurane"
],
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73,
84
]
],
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}
]
},
{
"id": "DerAnaesthesist.70461050.eng.abstr-s1-t3",
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"enflurane"
],
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89,
98
]
],
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{
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}
]
},
{
"id": "DerAnaesthesist.70461050.eng.abstr-s1-t4",
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"text": [
"dry"
],
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[
133,
136
]
],
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}
]
},
{
"id": "DerAnaesthesist.70461050.eng.abstr-s1-t5",
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"lime"
],
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142,
146
]
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}
]
},
{
"id": "DerAnaesthesist.70461050.eng.abstr-s1-t6",
"type": "umlsterm",
"text": [
"soda lime"
],
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[
137,
146
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0074716"
}
]
}
] |
[] |
[] |
[
{
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"type": "affects",
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},
{
"id": "DerAnaesthesist.70461050.eng.abstr-s1-r4-t2.1-t5.1",
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] |
DerAnaesthesist.70461054.eng.abstr
|
DerAnaesthesist.70461054.eng.abstr
|
[
{
"id": "DerAnaesthesist.70461054.eng.abstr-passage-0",
"type": "abstract",
"text": [
"All volatile anesthetics undergo chemical breakdown to multiple , partly identified degradation products in the presence of dry soda lime . These chemical reactions are highly exothermic , ranging from 100 ° C for halothane to 120 ° C for sevoflurane . The increase in temperature correlates with the moisture content of the soda lime , being maximal below 5% . Sevoflurane and isoflurane were exposed to dry soda lime in a circle system . The anaesthetic gas was condensed in a series of cold temperature traps and the degradation products of the volatile anesthetics were analysed using GC/MS . Surprisingly , neither sevoflurane nor its degradation products could be measured in the gas-flow emerging from the soda lime during the first 15-20 min of exposure . After 20 minutes , larger quantities of methanol , compounds C and D as well as compounds A and B were detected . After 40-60 min of exposure , sevoflurane's degradation markedly decreased and unaltered sevoflurane emerged from the soda lime canister . Additionally , using isoflurane in the same experimental set-up resulted in various degradation products due to its reaction with dry soda lime . Obviously , all volatile anesthetics are prone to such a reaction . In conclusion , sevoflurane and isoflurane react with dry soda lime . These reactions are caused by the presence of two components of soda lime , sodium hydroxide and potassium hydroxide . A modification of soda lime to prevent its reaction with volatile anaesthetics is discussed ."
],
"offsets": [
[
0,
1513
]
]
}
] |
[
{
"id": "DerAnaesthesist.70461054.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"anesthetics"
],
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13,
24
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},
{
"id": "DerAnaesthesist.70461054.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"degradation"
],
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84,
95
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"soda lime"
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128,
137
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"id": "DerAnaesthesist.70461054.eng.abstr-s2-t1",
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214,
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"id": "DerAnaesthesist.70461054.eng.abstr-s2-t2",
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"sevoflurane"
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239,
250
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"id": "DerAnaesthesist.70461054.eng.abstr-s3-t1",
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"temperature"
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269,
280
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]
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{
"id": "DerAnaesthesist.70461054.eng.abstr-s3-t2",
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"lime"
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334
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{
"id": "DerAnaesthesist.70461054.eng.abstr-s3-t3",
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"soda lime"
],
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325,
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{
"id": "DerAnaesthesist.70461054.eng.abstr-s4-t1",
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"Sevoflurane"
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362,
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"text": [
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DerAnaesthesist.70461064.eng.abstr
|
DerAnaesthesist.70461064.eng.abstr
|
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329
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[] |
[] |
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DerAnaesthesist.70461071.eng.abstr
|
DerAnaesthesist.70461071.eng.abstr
|
[
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"type": "abstract",
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"The various components of commercial soda lime ( sodium hydroxide , potassium hydroxide , calcium hydroxide , barium hydroxide ) were studied in terms of their reactivity with sevoflurane at its boiling point ( 59 ° C ) . A simple closed system , a reflux cooler , served as a model . Analyses were performed by GC/MS . Besides sevoflurane , we identified four compounds : A , B , C , and D. Free methanol , formaldehyde and formic acid could not be found . Presumably methanol is transferred from an intermediate formalin-semiacetal of the hexafluorisopropanol . Calcium hydroxide and barium hydroxide showed little reaction with sevoflurane , whereas larger amounts of reaction products were observed with sodium hydroxide and potassium hydroxide . The alkali hydroxides of sodalime are presumably responsible for its reaction with halogenated inhalation anaesthetics . We therefore conclude that decomposing reactions of halogenated inhalation anesthetics with dry soda lime could be prevented by using a newly developed soda lime ."
],
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0,
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] |
[] |
[] |
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] |
DerAnaesthesist.70461076.eng.abstr
|
DerAnaesthesist.70461076.eng.abstr
|
[
{
"id": "DerAnaesthesist.70461076.eng.abstr-passage-0",
"type": "abstract",
"text": [
"For incidents of malignant hyperthermia ( MH ) outside the hospital , a high number of unrecorded cases must be reckoned with because of an insufficient knowledge of emergency services and poor identification and documentation that make it impossible to classify acute situations under the diagnosis of malignant hyperthermia crisis . As a result , there are no statistical data in this field , and only case reports with a broad spectrum of suspected trigger mechanisms have been published . The case described in this report is a proved example of a non-anesthesia-related triggering of MH in a 21-year-old man who had had an anesthetic-induced MH manifestation in childhood , which was confirmed with an in vitro contracture test . After visiting a restaurant , he became unconscious and convulsive after consuming a high level of alcohol ( 2.9permil ) . The first cardiocirculatory arrest occurred directly before hospitalization . After admission , the patient showed a full-blown MH episode whose subsequent fatality was unavoidable in spite of adapted and optimal therapy . Suspected trigger mechanisms seem to be multifactoral ( excessive alcohol consumption , over-heating , mental stress ) as a forensic investigation did not point to any particular signs of typical trigger substances . The case demonstrates again that an MH attack might be triggered under certain non-anaesthesia-related situations . For patients with an MH disposition , additional information on their behavior outside the hospital is required ."
],
"offsets": [
[
0,
1527
]
]
}
] |
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] |
[] |
[] |
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] |
DerAnaesthesist.7046s003.eng.abstr
|
DerAnaesthesist.7046s003.eng.abstr
|
[
{
"id": "DerAnaesthesist.7046s003.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Among anaesthetic drugs , ketamine occupies a special position . Biochemically , ketamine is a racemate consisting of equal shares of two optical enantiomers . Pharmacological investigations show differences between those enantiomers in both qualitative and quantitative properties . Furthermore , clinical superiority of S- ( + ) -ketamine has been described in different therapeutic studies with regard to anaesthetic potency , the extent of analgesia , effects and side effects during and after the operation , and undiserable psychological dysfunction . On a neuropharmacological basis , the clinical superiority of S- ( + ) -ketamine is due to its effect on NMDA receptors in central nervous tissue , opioid receptors on both central and peripheral levels , and noradrenergic , dopaminergic , and serotoninergic mechanisms . The main problems associated with the ketamine racemate in clinical use are desirable psychological dysfunction and a prolonged period of arousal . There are grounds for the assumption that the use of S- ( + ) -ketamine will minimise those problems without reducing anaesthetic potency or restricting the advantages of ketamine anaesthesia ."
],
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[
0,
1171
]
]
}
] |
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[] |
[] |
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] |
DerAnaesthesist.7046s008.eng.abstr
|
DerAnaesthesist.7046s008.eng.abstr
|
[
{
"id": "DerAnaesthesist.7046s008.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Although ketamine has been in clinical use for 3 decades , the neuropharmacological basis of its analgesic , anaesthetic , sympathomimetic , and psychotomimetic effects is still a subject of controversial discussion and intensive investigational efforts . In recent years , however , new experimental approaches to its effects on the cellular and molecular level and the availability of pure ketamine enantiomers contributed substantially to the understanding of its complex neuropharmacology . This article reviews the current knowledge of ketamine effects on ligand-operated and voltage-operated transmembrane ion channels , G-protein-coupled receptors , transmitter uptake , and the NO-cGMP system in neurons . With regard to its potential clinical relevance and supposed relative role among the complex mechanisms involved in pain perception , analgesia , anaesthesia , and psychotomimesis , the contributions of recent experimental and clinical findings to the identification of major target sites of ketamine are summarised . In contrast to the uncertainty surrounding the potential role of opioid receptors , there is now considerable evidence that NMDA antagonism is a central mechanism that contributes to the amnesic , analgesic , anaesthetic , and psychotomimetic as well as the neuroprotective actions of ketamine . Moreover , the involvement of non-NMDA glutamate receptors , muscarinic and nicotinic cholinergic transmission , interactions with 5-HT receptors , and L-Type Ca2+ channels may account for some of its anaesthetic and neuroprotective properties ."
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DerAnaesthesist.7046s020.eng.abstr
|
DerAnaesthesist.7046s020.eng.abstr
|
[
{
"id": "DerAnaesthesist.7046s020.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The present review summarises the main actions of racemic ketamine and ketamine enantiomers on central nervous system receptors . The primary CNS action of ketamine appears to be a non-competitive block of N-methyl-D-aspartate receptors . Although numerous other receptors ( e.g. , GABA , nicotinic acetylcholine , opiate , voltage-operated channels ) have been reported to interact with ketamine , their role in inducing dissociative anaesthesia is still under discussion . In humans , characteristic electroencephalographic ( EEG ) changes after administration of ketamine are dose-dependent increases in delta , theta , and beta power . In equipotent doses S- ( + ) -ketamine induces similar EEG changes . However , in comparison to racemic ketamine and S- ( + ) -ketamine , R- ( - ) -ketamine does not suppress the EEG to the same extent . Former studies suggested that ketamine is a proconvulsive agent ; however , recent studies have demonstrated anticonvulsive and even neuroprotective properties . In humans , low-dose ketamine has no influence on early cortical peaks of somatosensory evoked potentials ( SEP ) . Larger doses induce increases in SEP amplitude while latencies are unchanged . Recent data indicate that analgesia induced by low-dose ketamine may be quantitated by specific pain-related SEP . Significant reductions of pain-induced cortical potentials may be correlated with subjective pain ratings . Brain-stem auditory evoked potentials ( AEP ) are not influenced by ketamine . Interestingly , in contrast to many other anaesthetics , middle- latency AEP were not altered by racemic and S- ( + ) -ketamine . This observation may indicate insufficient suppression of auditory stimulus processing during ketamine anaesthesia . Motor evoked responses to transcranial electrical or magnetic stimulation in humans are not markedly suppressed by ketamine ."
],
"offsets": [
[
0,
1875
]
]
}
] |
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DerAnaesthesist.7046s047.eng.abstr
|
DerAnaesthesist.7046s047.eng.abstr
|
[
{
"id": "DerAnaesthesist.7046s047.eng.abstr-passage-0",
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"A key question in cellular neuroprotection is how pharmacologic agents may protect neurons when applied after injury in clinically relevant concentrations . Of special importance is the N-methyl-D-aspartate ( NMDA ) antagonist ketamine , which offers the potential for regulation of intracellular calcium levels and pathophysiological NO induction by blocking excessive NMDA-receptor stimulation . This may reduce progressive neuronal degeneration and cell death . Initial evidence for ketamine's neuroprotective effects came from cell culture studies demonstrating increased neuronal and astroglial viability , preserved cellular morphology , and reduced cell swelling subsequent to anoxia-hypoxia or glutamate injury and ketamine application . Moreover , ketamine was found to protect cellular energy status after ischaemic insults and maintained ATP production , glucose metabolism , and mitochondrial transmembrane potentials . Subsequent studies have revealed ketamine's regulating effects on intracellular ion homeostasis , thus stabilising neuronal electrophysiological functions . In addition , ketamine was reported to maintain a glutamate-associated induction of intrinsic-neuronal protective nerve growth factors , and recent evidence suggests that S ( + ) -ketamine has a greater neuroprotective potential than ketamine racemate . S ( + ) - ketamine demonstrated a unique neuroregenerative potential that was associated with greater re-outgrowth of axonal neurites after mechanical injury and increased expression of growth-associated proteins after glutamate damage . S ( + ) -ketamine has a two- to four-fold higher affinity for the phencyclidine receptor of the NMDA receptor complex than ketamine racemate , and it is conceivable that the induction of a differentiated pattern of genes induces cellular growth activities via ketamine-mediated NMDA-receptor activation or blockade . However , further investigations elucidating ketamine's effects in animals and humans have to be performed before final decisions regarding a potential application of ketamine as a neuroprotective agent in the clinical setting can be made ."
],
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[
0,
2138
]
]
}
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{
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}
] |
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