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DerAnaesthesist.7046s055.eng.abstr
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DerAnaesthesist.7046s055.eng.abstr
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[
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"id": "DerAnaesthesist.7046s055.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The phencyclidine derivative ketamine is a non-competitive N-methyl-D-aspartate ( NMDA ) receptor antagonist with the thalamo-neocortical projection system as the primary site of action . Racemic ketamine consists of the enantiomers S ( + ) -ketamine and R ( - ) -ketamine . Racemic ketamine has never been considered an adequate anaesthetic agent in neurosurgical patients since it produces regionally specific stimulation of cerebral metabolism ( CMRO2) and increases cerebral blood flow ( CBF ) and intracranial pressure ( ICP ) . However , recent experiments suggest that both tracemic ketamine and S ( + ) -ketamine may reduce infarct size in animal models of incomplete cerebral ischaemia and brain injury . This experimental protective effect appears to be related to decreases in Ca++ influx and maintenance of brain tissue magnesium levels due to NMDA and quisqualate receptor blockade by ketamine . Studies in dogs have shown that racemic ketamine ( 2.0 mg/kg ) increases CBF in the presence of the cerebral vasodilator N2O. In contrast , studies in rats without background anaesthesia showed increases in CBF after racemic ketamine ( 100 mg/kg i.p. ) . This suggests that the cerebrovascular effects of racemic ketamine are related to the pre-existing cerebrovascular tone induced by background anaesthetics . Cerebrovascular CO2 reactivity was maintained regardless of the baseline cerebrovascular resistance . There are several mechanisms by which racemic ketamine may increase CBF . It induces dose-dependent respiratory depression with consequent mild hypercapnia in spontaneously ventilating subjects . This produces vasodilation due to the intact cerebrovascular CO2 reactivity . Racemic ketamine also induces regional neuroexcitation , which leads to stimulation of cerebral glucose consumption in the limbic , extrapyramidal , auditory , and sensory-motor systems . This regional neuroexcitation with increased CMRO2 produces increases in CBF that can be blocked by infusion of barbiturates or benzodiazepines . However , increases in CBF with racemic ketamine ( 1 mg/kg ) may also occur during normocapnia and without changes in CMRO2. This effect is related to some additional direct cerebral vasodilating potency of racemic ketamine based on a mechanism involving blockade of Ca++ channels . The effects of racemic ketamine on CBF autoregulation have not been investigated systematically . However , studies in rats have shown that CBF autoregulation was maintained with low- and high-dose S ( + ) -ketamine . Infusion of racemic ketamine alters intracranial volume and ICP . Studies in spontaneously ventilating pigs with and without intracranial hypertension have shown that racemic ketamine ( 0.5-5.0 mg/kg ) produces increases in PaCO2 and ICP . In contrast , identical experiments with mechanical ventilation and controlled PaCO2 showed no changes in ICP following racemic ketamine infusion . This implies that increases in ICP are related to inadequate ventilation with consecutive hypercapnia and increases in intracranial blood volume . However , mechanical ventilation may not be sufficient to control ICP following racemic ketamine . Experiments in mechanically ventilated dogs indicate that racemic ketamine ( 2 mg/kg ) increases cerebral blood volume and ICP even in the presence of normoventilation , a response that is reversible by hyperventilation or the administration of diazepam . Studies in patients have shown that racemic ketamine ( 2.0 mg/kg ) reduces CBF in the presence of cerebral vasodilators like halothane or N2O. In contrast , studies in unanaesthetised humans showed increases in CBF after racemic ketamine ( 2-3 mg/kg ) . This observation is consistent with animal studies and suggests that the cerebrovascular effects of racemic ketamine are related to the pre-existing cerebrovascular tone induced by background anaesthetics ."
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] |
[] |
[] |
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DerAnaesthesist.7046s061.eng.abstr
|
DerAnaesthesist.7046s061.eng.abstr
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"This review focuses on the significance of S- ( + ) -ketamine as a neuroprotective agent . Evidence in the literature supporting or contradicting a neuroprotective or even therapeutic role of ketamine in global cerebral ischaemia is critically reviewed , and data from an ongoing study in a rat global cerebral ischaemia model ( 15 min ischaemia with S ( + ) -ketamine administered 15 min after reperfusion ) are reported . The number of experimental studies available so far limited , however , and therefore results cannot be considered conclusive at the present time . Only at higher ketamine dosages was protection found reliably , especially in models of complete forebrain ischaemia lasting over 10 min . In our own study , only after 90 mg/kg S ( + ) -ketamine was there significantly better preservation of cortical neurons than without treatment ; 30 and 60 mg/kg did not produce this effect ."
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[] |
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] |
DerAnaesthesist.7046s065.eng.abstr
|
DerAnaesthesist.7046s065.eng.abstr
|
[
{
"id": "DerAnaesthesist.7046s065.eng.abstr-passage-0",
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"text": [
"As the mechanism of action of ketamine , particularly its non-competitive antagonism at the N-methyl-d-aspartate receptor ( NMDA ) , has become better understood , the use of the drug as a neuroprotective agent has received increasing interest . Although the potential prometabolic effects of ketamine might be counterproductive to neuroprotection , the increase in intracranial pressure it has repeatedly been reported to produce does not appear to be relevant clinically under certain conditions , e.g. in patients with normocapnia and a stable blood pressure . Also , the drug has been shown to be anticonvulsant in clinically applied doses rather than epileptogenic , as was previously assumed . These insights have opened up entirely new perspectives for the use of ketamine as a neuroprotective agent . But as both in vitro and in vivo studies are inconclusive , the benefits of the drug are still controversial . In addition , the potential neurotoxicity attributed to extremely high ketamine doses is poorly understood . Consequently , well controlled animal experiments and studies in humans would be necessary to establish the role of ketamine and its more potent enantiomer S- ( + ) -ketamine in combination with other neuroprotective measures and to shed light on its true neuroprotective potential and its possible neuroregenerative effects ."
],
"offsets": [
[
0,
1355
]
]
}
] |
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DerAnaesthesist.7046s074.eng.abstr
|
DerAnaesthesist.7046s074.eng.abstr
|
[
{
"id": "DerAnaesthesist.7046s074.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The shift of age distribution within the population of industrialized societies has led to an increased need of treating diseases in elderly patients and at the same time in a higher number of patients bearing an increased operative risk . Today , the development of surgical techniques and intensive care treatment enables us to carry out numerous procedures in geriatric patients . Innovative surgical techniques like minimal invasive surgery with minor trauma due to the surgical approach changed patient's categories , also . Taken together with other procedures causing less operative stress indications for patients who were not operable previously have changed . New developments such as organ transplantation and immunosuppression also generated totally new groups of patients with very distinct conditions for the operative procedure . Vanishing indications or selection of patients as in peptic ulcer disease changed the surgical approach completely : Negative selection has shifted elective operative interventions in ulcer disease to emergency procedures . Contrasting experiences made in most other countries and especially in the third world , in Germany economic restrictions have not been encountered as of yet . Economical conditions , an increase in surgical procedures in elderly patients and advances in medical science will continue to change the surgical patient's characteristics profoundly . From the physicians viewpoint we have to actively participate in this development by personal interaction with the patient , by interdisciplinary cooperation and prompt social and political action ."
],
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}
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DerAnaesthesist.7046s080.eng.abstr
|
DerAnaesthesist.7046s080.eng.abstr
|
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"Besides other reasons , cost containments mandate the rational use of preoperative screening tests which should be adapted to the risk of the individual patient . Since the perioperative cardiac risk increases with age , elderly patients in particular require a thorough evaluation of their perioperative risk . Routine ECG , however , is not indicated in patients under 45 years of age who do not present with signs or history of preexisting cardiac diseases but should be performed on a routine basis in all patients over 45 years of age . The validity of an ergometer test as a preoperative indicator of myocardial ischemia is limited due to a high incidence of false negative results . By preoperative routine chest radiography previously unknown findings are only detected in a small number of patients ; thus , in patients of ASA-risk groups I-II younger than 74 years of age routine chest-x-ray cannot be justified . In patients whose perioperative cardiac risk as assessed clinically and by ECG is ambiguous , dipyridamole-thallium-myocardial scintigraphy ( DTMS ) and dobutamine-stress-echocardiography may contribute valuable information regarding the prediction of perioperative adverse cardiac events . In that respect , dobutamine-stress-echocardiography appears to be superior to DTMS . The laboratory tests required in patients of different ASA-risk groups and according to their age are presented in an overview ."
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] |
DerAnaesthesist.7046s085.eng.abstr
|
DerAnaesthesist.7046s085.eng.abstr
|
[
{
"id": "DerAnaesthesist.7046s085.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Perioperative morbidity and mortality in noncardiac surgery are mainly due to cardiovascular complications . Therefore , perioperative risk assessment is crucial to avoid these adverse events . In patients above the age of 40 years , the ECG is a basic investigation , often providing hints for cardiovascular diseases . Stress testing and , in special cases , stress echocardiography or scintigraphy ( the latter only in those patients , in which exercise is impossible ) can detect significant coronary artery disease . The vascularization reduced the perioperative risk in particular in those patients with unstable angina or severe coronary artery disease . However , prophylactic revascularization the stable patient does not improve overall outcome , because the risk of the revascularizing procedure must be added to the risk of noncardiac surgery . Other diagnostic procedures like echocardiography , chest roentgenogram , routine scintigraphy , halter ECG or halter blood pressure measurement do not add information to the perioperative risk assessment , although these techniques might be very relevant in evaluating other coexisting diseases ( heart failure ; valve lesions , in particular aortic stenoses etc. ) and can be useful to improve medical treatment preoperatively ( e.g. normalization of blood pressure ) ."
],
"offsets": [
[
0,
1328
]
]
}
] |
[
{
"id": "DerAnaesthesist.7046s085.eng.abstr-s1-t1",
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"morbidity"
],
"offsets": [
[
14,
23
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0220880"
},
{
"db_name": "UMLS",
"db_id": "C0026538"
}
]
},
{
"id": "DerAnaesthesist.7046s085.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"mortality"
],
"offsets": [
[
28,
37
]
],
"normalized": [
{
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"db_id": "C0026566"
},
{
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}
]
},
{
"id": "DerAnaesthesist.7046s085.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"surgery"
],
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52,
59
]
],
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]
},
{
"id": "DerAnaesthesist.7046s085.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
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DerAnaesthesist.7046s099.eng.abstr
|
DerAnaesthesist.7046s099.eng.abstr
|
[
{
"id": "DerAnaesthesist.7046s099.eng.abstr-passage-0",
"type": "abstract",
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"The perioperative morbidity and mortality is mainly influenced by the type and duration of surgery as well as the patient's preoperative state of health . Anesthesia per se , however , may also result in severe perioperative ( patho ) physiological changes , which may be both desired ( e.g. analgesia , vasodilation in vascular surgery ) or detrimental ( e.g. hypothermia , ventilatory depression ) and which may differ depending on the anesthetic technique used ( e.g. general anesthesia vs. regional anesthesia ) . Yet , all anesthestic techniques have in common , that their effects are not limited to the duration of the surgical intervention , but may expand far into the postoperative period . Therefore , many trials have been performed in the past aiming to compare the impact of different anesthetic techniques on the incidence of postoperative techniques , no significant advantage of one or the other technique has been identified up to now with respect to postoperative mortality or severe morbidity . This finding may be due to at least three factors . 1 ) Many side-effects related to anesthesia - due to close postoperative monitoring - are detected and treated early in the postoperative phase ( e.g. in the recovery room ) , thereby preventing serious complications . 2 ) Postoperative mortality related exclusively to anesthesia probably is so low , that huge patient numbers would be required to demonstrate any significant differences between different techniques . 3 ) Besides the factor ' anesthesia ' , may other factors contribute to the anesthesia related morbidity and mortality ( e.g. the factor ' anesthetist ' ) which are hardly quantified . The fact that clear advantages for a single technique have not yet been demonstrated must not , however , result in anesthetic ' nihilism ' . Rather there may be good reasons in the individual patient ( e.g. lack of a recovery room ) , to prefer a certain anesthetic technique or drug over another , in order to lower the individual risk of anesthesia . Whether the use of a certain technique - e.g. spinal or epidural anesthesia - may contribute to a reduction of specific postoperative surgical complications ( e.g. rate of reocclusion subsequent to peripheral vascular surgery ) is presently under investigation ."
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DerAnaesthesist.7046s109.eng.abstr
|
DerAnaesthesist.7046s109.eng.abstr
|
[
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"id": "DerAnaesthesist.7046s109.eng.abstr-passage-0",
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"Historically , recovery rooms were established in order to reduce complications in the period immediately following surgery and anaesthesia , utilising staffing and equipment resources economically . To minimise the incidence of postoperative complications remains the main task of post anaesthesia care units ( PACU ) . However , especially in hospitals with a high degree of surgical emergencies , the scope of tasks and procedures within the PACU has expanded . Facing restricted capacities in intensive therapy ( ITU ) and high dependency units ( HDU ) the PACU serves as a buffer ; intensive care functions can be covered here until the patient can be admitted to an intensive care unit . In this context , the PACU also has a switch function ; postoperatively , the patient is evaluated here and the level for further treatment determined : ITU , HDU , or normal ward . The PACU period can be utilised to improve the patient's condition ( upgrade function ) enabling continuation of treatment on a lower level ( HDU instead of ITU , normal ward instead of HDU ) . This combination of buffer , switch and upgrade function is of special importance when ITU and HDU resources are limited . A new task for the PACU arises from efforts to optimise acute pain therapy ; initial adjustment of continuous infusion systems according to the patients ' needs can be performed here without additional staffing requirements . Finally , the PACU can be used preoperatively for \" tune up \" procedures in high risk patients . The basis for co-operation between anaesthetist and surgeon is the separation of responsibilities in combination with mutual trust . Accordingly , the anaesthetist is responsible for monitoring and maintenance of vital functions . Consequently , the anaesthetist has a professional and organisational responsibility in the PACU . The surgeon can and must rely on notification whenever surgical complications may require his intervention . With increasing comorbidity of patients and complexity of surgical procedures the anaesthetist's responsibility in the immediate perioperative period gains a new quality . The number of surgical procedures requiring intraoperative intensive therapy from the anaesthetist is increasing ; the delivery of anaesthesia becomes a background task during these operations . Thus , the anaesthetist becomes responsible for perioperative patient treatment in the operating room area which divides into three phases : preoperative \" tune up \" in the PACU ( e.g. ) haemodynamic optimisation , starting continuous regional anaesthesia techniques ) , anaesthesia and support of vital functions in the OR , and immediately postoperative treatment in the PACU ."
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{
"id": "DerAnaesthesist.7046s109.eng.abstr-s16-r3-t1.1-t7.1",
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] |
DerAnaesthesist.7046s143.eng.abstr
|
DerAnaesthesist.7046s143.eng.abstr
|
[
{
"id": "DerAnaesthesist.7046s143.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Many patients still suffer from unnessesary pain in the postoperative period . Waiting for new technologies or drugs will not improve the status of acute pain management . The establishment of an acute service is needed to reduce the incidence of postoperative pain . Acute pain therapy is one of the great challenges we have to take up ."
],
"offsets": [
[
0,
338
]
]
}
] |
[
{
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"patients"
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5,
13
]
],
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},
{
"id": "DerAnaesthesist.7046s143.eng.abstr-s1-t2",
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],
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44,
48
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{
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},
{
"id": "DerAnaesthesist.7046s143.eng.abstr-s1-t3",
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"postoperative"
],
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56,
69
]
],
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{
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]
},
{
"id": "DerAnaesthesist.7046s143.eng.abstr-s1-t4",
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"period"
],
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[
70,
76
]
],
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{
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}
]
},
{
"id": "DerAnaesthesist.7046s143.eng.abstr-s1-t5",
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"postoperative period"
],
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56,
76
]
],
"normalized": [
{
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},
{
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"technologies"
],
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95,
107
]
],
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},
{
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"drugs"
],
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111,
116
]
],
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{
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}
]
},
{
"id": "DerAnaesthesist.7046s143.eng.abstr-s2-t3",
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"pain"
],
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154,
158
]
],
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{
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},
{
"id": "DerAnaesthesist.7046s143.eng.abstr-s2-t4",
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],
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154,
169
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}
]
},
{
"id": "DerAnaesthesist.7046s143.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"incidence"
],
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[
234,
243
]
],
"normalized": [
{
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},
{
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]
},
{
"id": "DerAnaesthesist.7046s143.eng.abstr-s3-t2",
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],
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247,
260
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{
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],
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261,
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{
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],
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247,
265
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],
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274,
278
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],
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]
},
{
"id": "DerAnaesthesist.7046s143.eng.abstr-s4-t2",
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],
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279,
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]
},
{
"id": "DerAnaesthesist.7046s143.eng.abstr-s4-t3",
"type": "umlsterm",
"text": [
"pain therapy"
],
"offsets": [
[
274,
286
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0002766"
}
]
}
] |
[] |
[] |
[
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"type": "evaluation_of",
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},
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{
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{
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{
"id": "DerAnaesthesist.7046s143.eng.abstr-s2-r6-t2.1-t1.1",
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},
{
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},
{
"id": "DerAnaesthesist.7046s143.eng.abstr-s3-r2-t4.1-t3.1",
"type": "associated_with",
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},
{
"id": "DerAnaesthesist.7046s143.eng.abstr-s4-r1-t2.1-t1.1",
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}
] |
DerAnaesthesist.7046s147.eng.abstr
|
DerAnaesthesist.7046s147.eng.abstr
|
[
{
"id": "DerAnaesthesist.7046s147.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Nociception is a protective system of the body which prevents it from injury and tissue damage . Human beings respond to noxious stimuli by moving away . They learn by pain to avoid these situations in future . Shortly after major injury , there is a limited analgesic period allowing the body to flee the area of danger , later on , emerging pain compels the body to rest and supports recuperation . While acute pain has a certain meaning , chronic pain does not . It induces a comprehensive suffering including loss of initiative , appetite and vigilance . It reduces life-quality , often accompanied by depressive moods . Acute pain causes changes in the central nervous system leading to an increased sensitivity of nociception ( hyperalgesia ) . During healing , the central processing of noxious stimuli is normalised taking minutes to weeks . Sometimes , unknown factors initiate chronification of pain . Changes on a molecular level in peripheral tissue as well as in the central nervous system induce \" cellular early genes \" [ 24 ] , a synthesis of c-fos , c-jun and other proteins favouring the chronification of pain . All efforts have to be made to depress or interrupt such a development . One of the first steps to pain prophylaxis in a hospital is an optimal surgical technique : incision , extension , limited tissue damage and minimal invasive surgery should guarantee the smallest impairment of the nociceptive system possible . However , nociceptive input is intense and of long duration and leads to central sensibilisation . Postoperative pain has lost its function as surgery anticipates healing . Pain induces a reduction of ventilation , circulation , digestion and increases the risk of other disorders . There is need of aggressive pain treatment for humanitarian reasons and for reasons of late sequelae like permanent pain and increased reduction of function [ 10 ] . This is of pivotal importance in patients with amputations or sympathetic reflex dystrophy ( SRD ) . Antinociception is best provided by regional anaesthesia technique with a combination of local anaesthetics and opioids which results in better outcome [ 2 , 12 ] . Hence , regional anaesthesia techniques are strongly indicated in those patients . Good antinociception may be even more important than it is assumed today . Anand [ 1 ] demonstrated a lower morbidity and mortality in 45 newborns undergoing cardiothoracic surgery , when general anaesthesia was performed with high-dose sufentanil versus halothane supplementary doses of morphine . Anaesthesiologists have to reconsider the quality of general anaesthesia : the antinociception of their regimen ."
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DerAnaesthesist.7046s154.eng.abstr
|
DerAnaesthesist.7046s154.eng.abstr
|
[
{
"id": "DerAnaesthesist.7046s154.eng.abstr-passage-0",
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"The administration of epidural opioids is alternatively used in the management of postoperative analgesia . However , the administration is associated with side effects , including respiratory depression , somnolence and pruritus . A rational opioid selection between the hydrophilic and lipophilic opioids morphine , hydromorphone , alfentanil , fentanyl and sufentanil is discussed in this mini-review . Thus , the administration of the lipophilic opioid sufentanil might has some advantages . Notwithstanding , epidural opioid administration alone offers no marked clinical advantages compared to the intravenous route . In future , reduced doses of lipophilic opioids and local anaesthetics like bupivacaine 0.05-0.1% may provide benefits over the use of either drug alone and may offer marked clinical advantages over the intravenous route of opioids alone . The same holds true for 2-adrenoceptor agonists as adjuvants . However , multicenter dose-ranging studies are necessary to determine both the ideal concentrations of the drug combinations and the general outcome . Moreover , we must also determine cost effectiveness for our postoperative analgesic techniques ."
],
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}
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] |
[] |
[] |
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DerAnaesthesist.7046s159.eng.abstr
|
DerAnaesthesist.7046s159.eng.abstr
|
[
{
"id": "DerAnaesthesist.7046s159.eng.abstr-passage-0",
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"Until today , the use of epidural analgesia in obstetrics still remains controversial . In the opinion of many obstetricians the use of an epidural for a healthy laboring parturient is not necessary and can lead to potentially harmful side effects . However , painful labor leads to a maternal stress reaction with the release of epinephrine and norepinephrine . The resulting vasoconstriction of uterine arteries can induce fetal asphyxia in an otherwise healthy fetus or can aggravate asphyxia in already compromised fetusses . Several studies show that epidural analgesia can attenuate the maternal stress reaction and thereby improve maternal and fetal well-being , as long as precautions are taken . The avoidance of maternal hypotension with sufficient volume preload with lactated Ringer's solution or colloids , and decreasing the concentration of local anaesthetics by adding opioids will prevent an increase in instrumental deliveries . With the use of patient-controlled epidural analgesia ( PCEA ) the amount of local anaesthetics can even further be reduced ."
],
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DerAnaesthesist.7046s165.eng.abstr
|
DerAnaesthesist.7046s165.eng.abstr
|
[
{
"id": "DerAnaesthesist.7046s165.eng.abstr-passage-0",
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"text": [
"Side effects of postoperative epidural analgesia can be controlled by two strategies : Insertion of catheters into the center of the affected spinal segments and coadministration of local anesthestics and opioids . Both techniques will reduce single drug dosage . Additionally synergistic effects will result in excellent analgesia and the risk of side effects and complications will be minimized ."
],
"offsets": [
[
0,
398
]
]
}
] |
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29
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100,
109
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109
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250,
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}
] |
[] |
[] |
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},
{
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},
{
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"normalized": []
},
{
"id": "DerAnaesthesist.7046s165.eng.abstr-s1-r23-t7.1-t4.1",
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},
{
"id": "DerAnaesthesist.7046s165.eng.abstr-s1-r24-t3.1-t4.1",
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},
{
"id": "DerAnaesthesist.7046s165.eng.abstr-s1-r25-t4.1-t3.1",
"type": "diagnoses",
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},
{
"id": "DerAnaesthesist.7046s165.eng.abstr-s1-r26-t3.1-t5.1",
"type": "affects",
"arg1_id": "DerAnaesthesist.7046s165.eng.abstr-s3-t3",
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"normalized": []
},
{
"id": "DerAnaesthesist.7046s165.eng.abstr-s1-r27-t3.1-t5.1",
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},
{
"id": "DerAnaesthesist.7046s165.eng.abstr-s1-r28-t7.1-t5.1",
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"normalized": []
},
{
"id": "DerAnaesthesist.7046s165.eng.abstr-s1-r29-t4.1-t5.1",
"type": "affects",
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},
{
"id": "DerAnaesthesist.7046s165.eng.abstr-s1-r30-t3.1-t5.1",
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},
{
"id": "DerAnaesthesist.7046s165.eng.abstr-s1-r31-t7.1-t3.1",
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"normalized": []
},
{
"id": "DerAnaesthesist.7046s165.eng.abstr-s2-r1-t2.1-t1.1",
"type": "uses",
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"normalized": []
},
{
"id": "DerAnaesthesist.7046s165.eng.abstr-s3-r1-t2.1-t1.1",
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},
{
"id": "DerAnaesthesist.7046s165.eng.abstr-s3-r2-t2.1-t1.1",
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"normalized": []
},
{
"id": "DerAnaesthesist.7046s165.eng.abstr-s3-r3-t3.1-t1.1",
"type": "associated_with",
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"normalized": []
},
{
"id": "DerAnaesthesist.7046s165.eng.abstr-s3-r4-t5.1-t3.1",
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{
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},
{
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{
"id": "DerAnaesthesist.7046s165.eng.abstr-s3-r7-t3.1-t1.1",
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},
{
"id": "DerAnaesthesist.7046s165.eng.abstr-s3-r9-t1.1-t3.1",
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},
{
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}
] |
DerAnaesthesist.7046s172.eng.abstr
|
DerAnaesthesist.7046s172.eng.abstr
|
[
{
"id": "DerAnaesthesist.7046s172.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Background : Intravenous patient-controlled analgesia ( PCA-IV ) has markedly improved postoperative pain-relief . Alternatively , peridural anesthesia has been used successfully in high risk patients with the disadvantage of a more intense postoperative care . In this study we compared the applicability of intravenous vs. peridural patient-controlled analgesia on a general ward ."
],
"offsets": [
[
0,
383
]
]
}
] |
[
{
"id": "DerAnaesthesist.7046s172.eng.abstr-s1-t1",
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"analgesia"
],
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[
44,
53
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],
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{
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}
]
},
{
"id": "DerAnaesthesist.7046s172.eng.abstr-s1-t2",
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"text": [
"postoperative"
],
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87,
100
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],
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]
},
{
"id": "DerAnaesthesist.7046s172.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"pain-relief"
],
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[
101,
112
]
],
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{
"db_name": "UMLS",
"db_id": "C0030193"
}
]
},
{
"id": "DerAnaesthesist.7046s172.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"anesthesia"
],
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141,
151
]
],
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{
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}
]
},
{
"id": "DerAnaesthesist.7046s172.eng.abstr-s2-t2",
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"risk"
],
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187,
191
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]
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{
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"patients"
],
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[
192,
200
]
],
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{
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}
]
},
{
"id": "DerAnaesthesist.7046s172.eng.abstr-s2-t4",
"type": "umlsterm",
"text": [
"postoperative"
],
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[
241,
254
]
],
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},
{
"id": "DerAnaesthesist.7046s172.eng.abstr-s2-t5",
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255,
259
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{
"id": "DerAnaesthesist.7046s172.eng.abstr-s2-t6",
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"peridural anesthesia"
],
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[
131,
151
]
],
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]
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{
"id": "DerAnaesthesist.7046s172.eng.abstr-s2-t7",
"type": "umlsterm",
"text": [
"postoperative care"
],
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[
241,
259
]
],
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{
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]
},
{
"id": "DerAnaesthesist.7046s172.eng.abstr-s3-t1",
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],
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354,
363
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},
{
"id": "DerAnaesthesist.7046s172.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"ward"
],
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[
377,
381
]
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]
},
{
"id": "DerAnaesthesist.7046s172.eng.abstr-s3-t3",
"type": "umlsterm",
"text": [
"general ward"
],
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[
369,
381
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0043030"
}
]
}
] |
[] |
[] |
[
{
"id": "DerAnaesthesist.7046s172.eng.abstr-s1-r1-t1.1-t3.1",
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},
{
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"normalized": []
},
{
"id": "DerAnaesthesist.7046s172.eng.abstr-s2-r2-t3.1-t5.1",
"type": "performs",
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"arg2_id": "DerAnaesthesist.7046s172.eng.abstr-s2-t5",
"normalized": []
},
{
"id": "DerAnaesthesist.7046s172.eng.abstr-s2-r3-t5.1-t3.1",
"type": "affects",
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},
{
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},
{
"id": "DerAnaesthesist.7046s172.eng.abstr-s2-r5-t5.1-t7.1",
"type": "isa",
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"normalized": []
},
{
"id": "DerAnaesthesist.7046s172.eng.abstr-s2-r6-t2.1-t5.1",
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},
{
"id": "DerAnaesthesist.7046s172.eng.abstr-s2-r7-t3.1-t1.1",
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"normalized": []
},
{
"id": "DerAnaesthesist.7046s172.eng.abstr-s2-r8-t2.1-t5.1",
"type": "conceptual_part_of",
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"normalized": []
},
{
"id": "DerAnaesthesist.7046s172.eng.abstr-s2-r9-t1.1-t3.1",
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},
{
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{
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{
"id": "DerAnaesthesist.7046s172.eng.abstr-s2-r12-t2.1-t7.1",
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{
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{
"id": "DerAnaesthesist.7046s172.eng.abstr-s3-r1-t1.1-t3.1",
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"normalized": []
},
{
"id": "DerAnaesthesist.7046s172.eng.abstr-s3-r2-t1.1-t2.1",
"type": "uses",
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"arg2_id": "DerAnaesthesist.7046s172.eng.abstr-s3-t2",
"normalized": []
}
] |
DerAnaesthesist.7046s179.eng.abstr
|
DerAnaesthesist.7046s179.eng.abstr
|
[
{
"id": "DerAnaesthesist.7046s179.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Postoperative neurological sequelae in patients that have received epidural anaesthesia are not necessarily caused by the epidural anaesthetic technique . As a whole , adverse neurological outcomes following epidural anaesthesia may be subdivided into 3 different ethiological categories . A first category involves events that are not at all caused by the epidural , but merely due to the interference of anaesthesia and/or surgery with a preexisting medical condition . A second category includes mishaps such as backache , arachnoiditis , and post-dural puncture headache that are solely due to the epidural anaesthesia . Finally , epidural anaesthesia may be a contributory factor in the development of post-anaesthetic complications attributable to a pre-existing medical condition that are triggered by anaesthesia , surgery or childbirth . These complications include some of the most dramatic sequelae of major neuraxial blockade , such as spinal epidural abscess , spinal infarction , and spinal hematoma . Although extremely rare , the latter complications often result in permanent major neurological deficits . The present manuscript is a review of the most recent , literature addressing post-anaesthetic sequelae , and will discuss their incidence , pathophysiology , clinical course , diagnosis , prevention , and treatment ."
],
"offsets": [
[
0,
1340
]
]
}
] |
[
{
"id": "DerAnaesthesist.7046s179.eng.abstr-s1-t1",
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"Postoperative"
],
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[
0,
13
]
],
"normalized": [
{
"db_name": "UMLS",
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}
]
},
{
"id": "DerAnaesthesist.7046s179.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"sequelae"
],
"offsets": [
[
27,
35
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0243088"
}
]
},
{
"id": "DerAnaesthesist.7046s179.eng.abstr-s1-t3",
"type": "umlsterm",
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"patients"
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[
39,
47
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},
{
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131,
142
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},
{
"id": "DerAnaesthesist.7046s179.eng.abstr-s1-t5",
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"technique"
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143,
152
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}
]
},
{
"id": "DerAnaesthesist.7046s179.eng.abstr-s1-t6",
"type": "umlsterm",
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"epidural anaesthesia"
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[
67,
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],
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},
{
"id": "DerAnaesthesist.7046s179.eng.abstr-s2-t1",
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{
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425,
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{
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]
},
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DerAnaesthesist.7046s187.eng.abstr
|
DerAnaesthesist.7046s187.eng.abstr
|
[
{
"id": "DerAnaesthesist.7046s187.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Effects of anaesthesia and analgesia on postoperative morbidity and mortality remain controversial . Numerous studies have demonstrated that epidural anaesthesia and pain relief by epidural analgesia reduces perioperative stress responses and thus may reduce postoperative morbidity and mortality . In patients undergoing vascular surgery , epidural anaesthesia diminished postoperative hypercoagulability . These patients may benefit from less thromboembolic complications as well as a reduced risk of a re-operation . However , regional anaesthesia does not affect cardiopulmonary morbidity or overall mortality significantly in most clinical studies . One reason for this disappointing finding may be the missing integration of improved postoperative pain relief into general surgical care . A multimodal therapeutic approach , which consists of preoperativ patient information , sufficient analgesia , early mobilisation and enteral feeding , may solve this discrepancy . Therefore , prospective controlled studies are needed to assess the influence of this perioperative approach on outcome ."
],
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[
0,
1097
]
]
}
] |
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] |
DerAnaesthesist.80470024.eng.abstr
|
DerAnaesthesist.80470024.eng.abstr
|
[
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"Treatment of severe acute respiratory distress syndrome ( ARDS ) with extracorporeal membrane oxygenation ( ECMO ) can be life-saving but requires maximal use of intensive care resources over prolonged periods of time , resulting in high costs . Little is known about the health-related quality of life ( HRQL ) in long-term survivors . This case-controlled retrospective study was designed to assess the health-related quality of life in long-term survivors of ARDS and ECMO-therapy ."
],
"offsets": [
[
0,
485
]
]
}
] |
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] |
[] |
[] |
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DerAnaesthesist.80470039.eng.abstr
|
DerAnaesthesist.80470039.eng.abstr
|
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{
"id": "DerAnaesthesist.80470039.eng.abstr-passage-0",
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"When looking for the possible cause of distortions in values measured for the determination of breath ethanol concentration ( BEC ) in artificially respirated patients , consideration must be given to the humidity and temperature of the gas examined . In the present study , the effects of humidified and warmed and of dry and cold air on the accuracy of a newly developed BEC measuring device , as compared to a reference model and to a conventional system , were examined in a lung model ."
],
"offsets": [
[
0,
491
]
]
}
] |
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{
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},
{
"id": "DerAnaesthesist.80470039.eng.abstr-s1-t7",
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"text": [
"humidity"
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205,
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{
"id": "DerAnaesthesist.80470039.eng.abstr-s1-t8",
"type": "umlsterm",
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"id": "DerAnaesthesist.80470039.eng.abstr-s1-t9",
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},
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"id": "DerAnaesthesist.80470039.eng.abstr-s2-t1",
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"text": [
"dry"
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319,
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{
"id": "DerAnaesthesist.80470039.eng.abstr-s2-t2",
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"db_id": "C0024109"
}
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}
] |
[] |
[] |
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},
{
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},
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},
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},
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},
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}
] |
DerAnaesthesist.80470045.eng.abstr
|
DerAnaesthesist.80470045.eng.abstr
|
[
{
"id": "DerAnaesthesist.80470045.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The value of BURP ( =backwards-upwards-rightwards-pressure of the larynx ) was tested as a improvement of the visualisation of the larynx . Simultaneously we wanted to assess the value of different predictive tests of a difficult intubation , which are easy to perform as bedside tests ."
],
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0,
287
]
]
}
] |
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9
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}
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"larynx"
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]
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131,
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"id": "DerAnaesthesist.80470045.eng.abstr-s2-t3",
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"intubation"
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] |
[] |
[] |
[
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},
{
"id": "DerAnaesthesist.80470045.eng.abstr-s1-r2-t1.1-t3.2",
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"arg2_id": "DerAnaesthesist.80470045.eng.abstr-s1-t3",
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},
{
"id": "DerAnaesthesist.80470045.eng.abstr-s1-r3-t2.2-t3.2",
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"arg2_id": "DerAnaesthesist.80470045.eng.abstr-s1-t3",
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},
{
"id": "DerAnaesthesist.80470045.eng.abstr-s2-r1-t4.1-t2.1",
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},
{
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},
{
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},
{
"id": "DerAnaesthesist.80470045.eng.abstr-s2-r5-t2.1-t4.1",
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},
{
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},
{
"id": "DerAnaesthesist.80470045.eng.abstr-s2-r8-t2.1-t1.1",
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"arg2_id": "DerAnaesthesist.80470045.eng.abstr-s2-t1",
"normalized": []
}
] |
DerAnaesthesist.80470054.eng.abstr
|
DerAnaesthesist.80470054.eng.abstr
|
[
{
"id": "DerAnaesthesist.80470054.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Syringe drivers are used in anaesthetics , intensive care and emergency medicine to deliver small volumes of highly potent drugs with continuous , constant and reproducible flow . For early recognition of interruptions of the drug delivery caused by occlusion of the infusion system , an alarm is triggered as soon as the system pressure exceeds a certain limit . The sensitivity of this alarm depends on the flow rate , type-specific cut-off pressure and the elastic parameters of the infusion system . The sudden release of pressure built up in the system after occlusion occurred can cause delivery of an uncontrolled drug bolus and hence an additional hazard . Methods : Six syringe drivers that are widely used in clinical practice were tested for alarm delay and bolus delivery in the event of an occlusion in the system . First , the alarm pressures at flow rates of 10 , 50 and 100 ml/h were measured . Then the alarm delay time and bolus volumes post-occlusion were assessed , using a basic infusion system ( syringe+single infusion set ) . Finally , several alterations to the system like extension , tap battery with germ filters or branching were made and their impact on alarm delay and bolus volume measured . Results : Because of the great differences in alarm pressures between the devices tested , there were marked differences in the alarm delay at same flow rates . Predictably , there was an indirect proportional link between alarm delay and flow rate . Using the basic infusion system , alarm delays between 23 s and 143 min were measured . In two of the tested syringe drivers , a pressure-release mechanism is activated with the pressure alarm , which prevented bolus application . In the other devices , release of the pressure in the occluded system caused boli of 0.5-7 ml . Variations in the actual syringe volume and insertion of a second connection tube had no impact on alarm delay and bolus volume . Tap batteries , parallel running syringe drivers or trapped air in the system , however , caused marked increase in both alarm delay ( 107% ) and bolus volume ( +147% ) . Discussion : Unidentified occlusions of the system cause grave malfunctioning of syringe drivers . While applying highly potent drugs , the discontinuation of drug delivery with subsequent bolus application can cause vital danger to the patient . As a result of the significant time delays in the pressure alarms , the devices tested do not provide sufficient protection against unrecognized system occlusion . Syringe drivers with adjustable alarm pressure can be set close to the actual infusion pressure . A further important point is that one should aim at a reduction in the elastic properties of the infusion set because of the great impact on alarm delay and bolus volume ."
],
"offsets": [
[
0,
2783
]
]
}
] |
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"Syringe"
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0,
7
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"id": "DerAnaesthesist.80470054.eng.abstr-s1-t2",
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DerAnaesthesist.80470059.eng.abstr
|
DerAnaesthesist.80470059.eng.abstr
|
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],
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0,
151
]
]
}
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DerAnaesthesist.80470087.eng.abstr
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"As far as the law concerning liability is concerned , guidelines , codes of practice , and medical standards are not contrasting concepts , nor do they indicate material differences ; instead , those terms describe more or less precisely the care that a physician is required to exercise when treating patients and that a judge is required to assess in a trial . Guidelines , codes of practice , and standards thus take effect not directly , but indirectly , in that both physician and judge retain a certain discretion in making decisions in a particular case . The current obsession with guideline - primarily based on economic considerations and present in all specialist areas - together with the increasingly detailed rules that are being issued , carries the risk that to medical profession may of its own doing become too restricted , that physicians will become limited in their choice of treatment , and that the criteria by which liability is assessed will become stricter , thus increasing the physician's risk of being held liable under civil or criminal law . We need to prevent a development taking place in which \" medical standards \" become \" standardized medicine \" , leading to a situation in which only what is stipulated in the form of a guideline or a code of practice will be paid for ( and hence only that can be done ) ."
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DerAnaesthesist.80470093.eng.abstr
|
DerAnaesthesist.80470093.eng.abstr
|
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0,
193
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[] |
[] |
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"id": "DerAnaesthesist.80470093.eng.abstr-s1-r16-t4.1-t1.1",
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},
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"id": "DerAnaesthesist.80470093.eng.abstr-s1-r18-t7.1-t4.1",
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"id": "DerAnaesthesist.80470093.eng.abstr-s1-r20-t8.1-t1.1",
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}
] |
DerAnaesthesist.80470111.eng.abstr
|
DerAnaesthesist.80470111.eng.abstr
|
[
{
"id": "DerAnaesthesist.80470111.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Currently undergoing a clinical trial a new miniaturized monoplane ultrasound probe potentially enhances the practicability of perioperative transesophageal echocardiography ( TEE ) without loss of echocardiographic quality . Methods : In the present prospective study , the nasally inserted miniaturized TEE probe was tested in 12 ventilated patients and compared with a conventional TEE probe . Echocardiographic quality was tested by two independent investigators by analyzing the percentage of the endocardium contour detection ( 50% , 50-75% , 75-100% ) in the left ventricular short- and long-axis views . Results : In 11 patients , more than 50% of endocardium were visualized continuously with both probes . Although the nasal TEE probe was inferior to conventional TEE in detecting lateral endocardium , automated endocardium detection compared well with both methods . Inter- and intraobserver variability in manual measurements of the left ventricular cross-sectional area was below 5% on average and differed non-significantly with regard to the method . In 2 patients , continuous monitoring was aggravated by repeated loss of contact between the miniaturized TEE probe and mucosa . Conclusions : In comparison with conventional TEE , the miniaturized TEE probe provides practicability advantages without significant loss of information for cardiovascular monitoring ."
],
"offsets": [
[
0,
1381
]
]
}
] |
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}
] |
[] |
[] |
[
{
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] |
DerAnaesthesist.80470116.eng.abstr
|
DerAnaesthesist.80470116.eng.abstr
|
[
{
"id": "DerAnaesthesist.80470116.eng.abstr-passage-0",
"type": "abstract",
"text": [
"We investigated the effects of ultrapurified polymerized bovine hemoglobin ( HBOC-201) on skeletal muscle tissue oxygen tension when applied before establishment of a nearly complete arterial stenosis . Methods : Twelve foxhounds were anaes-thetized IV and mechanically ventilated with 30% oxygen in air . Catheters were inserted into the right femoral artery and vein for measurements of haemodynamic parameters and blood-gas sampling . Arterial blood flow of the left popliteal artery was measured by an electromagnetic flow probe . Skeletal muscle tissue oxygen tension ( tpo2) was measured in the left gastrocnemic muscle using a stepwise-driven polarographic needle probe , creating histograms from 200 single tpO2 measurements . Following isovolaemic haemodilution with Ringer's solution to a target haematocrit of 20% , the animals were randomly assigned to receive either 200 ml of predonated fresh blood ( group 1 ) or 200 ml of HBOC-201 ( MW 32000-500000 ; Hb 13 +/- 1 g - dl-1; group 2 ) . After a 15-min stabili-zation period , a 95% artificial stenosis of the left popliteal artery was established . While animals of group 1 received two applications of 200 ml 6% hetastarch ( HES , 200000 ; 0.5 ) , animals of group 2 received 200 ml Ringer's solution 45 and 75 min after establishment of the arterial stenosis , respectively . Variables were measured at baseline , after haemodilution and application of the respective compound , and 30 , 60 and 90 min after establishment of the stenosis . Results : Demographic data , muscle temperature and arterial blood gases did not differ between groups . With the exception of a higher mean pulmonary artery pressure in HBOC-201-treated animals , haemodynamics did not differ between groups . In both groups oxygen delivery and oxygen consumption of the muscle decreased in parallel to the de- creasing blood flow during arterial stenosis . In contrast , oxygen extraction ratio increased after infusion of HBOC-201 and remained unchanged during stenosis ( P 0.05 ) . In group 1 , the tpO2 decreased during stenosis when compared to baseline ( P 0.001 ) and remained decreased after administration of HES . In contrast , administration of 200 ml of HBOC-201 before establishment of the arterial stenosis sustained the tpO2 values at nearly baseline levels during stenosis . Skeletal muscle tissue oxygen tension was higher after HBOC-201 infusion during stenosis when compared to HES infusion ( P 0.001 ) . Conclusion : These data suggest that haemoglobin solutions can reach poststenotic tis-sues . The increased oxygen extraction after application of HBOC-201 is associated with improved skeletal muscle oxygen tension during severe arterial stenosis ."
],
"offsets": [
[
0,
2710
]
]
}
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]
}
] |
[] |
[] |
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DerAnaesthesist.80470136.eng.abstr
|
DerAnaesthesist.80470136.eng.abstr
|
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"The official German guidelines for prevention of intravascular-device-associated infections were published by the Bundesgesundheitsamt , now called the Robert-Koch-Institut , 12 years ago . The recently published official \" Guidelines for Prevention of Intravascular-Device Associated Infections \" of the Centers for Disease Control and Prevention ( CDC ) are categorized according to scientific evidence . The American guidelines are very detailed and differ in some aspects from the offical German guidelines . The purpose of the present paper is to inform the German-speaking anaesthesiologist about the official CDC guidelines and to provide an update on the prevention of intravascular-device-associated infections ."
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[] |
[] |
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DerAnaesthesist.80470172.eng.abstr
|
DerAnaesthesist.80470172.eng.abstr
|
[
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"id": "DerAnaesthesist.80470172.eng.abstr-passage-0",
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"All optically active molecules have at least one asymmetric atom in common which is attached to four ligands , that can have different three dimensional positions . Therefore it can be concluded that the resulting isomers are chemically identical in all respects except for the direction with which they rotate plane-polarized light . When the isomer and its corresponding enantiomer are present in equal proportions , they are called racemic mixture , a mixture that does not rotate polarized light , since the optical activities of the two isomers cancel each other . Although the isomers are chemically identical other optically active molecules can interact with these isomers in a geometrically specific way termed stereoselectivity . The human body comprises a chiral environment due to optically active proteins ; thus it is not surprising that enantiomeric drugs exhibit different pharmacological properties , when used as pure optical isomers . Till today most modern anaesthetics have been optical isomers , which are mainly used as racemic mixture ( 1:1 mixture ) . For financial reasons pure isomers were only used for research purposes , but nowadays the wide clinical use of pure isomers is financially feasible due to new production techniques . The terms eutomer and distomer were chosen to indicate the more or less potent form of the drug . The clinical use of pure isomers is only of advisable , if there are significant differences between eutomer and distomer in desired or side effects . Among the modern anaesthetics ketamine , isoflurane , bupivacaine and atracurium exhibit an asymmetric carbon . For most drugs the separation in pure isomers will reduce side effects . For volatile anaesthetics this question is still unanswered , since experimental and clinical results are inconsistent so far ."
],
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0,
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}
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1527,
1539
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{
"id": "DerAnaesthesist.80470172.eng.abstr-s10-t2",
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1540,
1548
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}
]
},
{
"id": "DerAnaesthesist.80470172.eng.abstr-s10-t3",
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"isoflurane"
],
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1551,
1561
]
],
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"db_id": "C0022180"
}
]
},
{
"id": "DerAnaesthesist.80470172.eng.abstr-s10-t4",
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"bupivacaine"
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1564,
1575
]
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}
]
},
{
"id": "DerAnaesthesist.80470172.eng.abstr-s10-t5",
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"atracurium"
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1580,
1590
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},
{
"id": "DerAnaesthesist.80470172.eng.abstr-s10-t6",
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"exhibit"
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1591,
1598
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],
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{
"db_name": "UMLS",
"db_id": "C0015272"
}
]
},
{
"id": "DerAnaesthesist.80470172.eng.abstr-s10-t7",
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"text": [
"carbon"
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1613,
1619
]
],
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},
{
"id": "DerAnaesthesist.80470172.eng.abstr-s11-t1",
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1631,
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]
},
{
"id": "DerAnaesthesist.80470172.eng.abstr-s11-t2",
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],
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1641,
1651
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],
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},
{
"id": "DerAnaesthesist.80470172.eng.abstr-s11-t3",
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1660,
1667
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},
{
"id": "DerAnaesthesist.80470172.eng.abstr-s11-t4",
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{
"id": "DerAnaesthesist.80470172.eng.abstr-s12-t1",
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"anaesthetics"
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1708,
1720
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0002932"
}
]
}
] |
[] |
[] |
[
{
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},
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},
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},
{
"id": "DerAnaesthesist.80470172.eng.abstr-s7-r1-t3.1-t6.1",
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},
{
"id": "DerAnaesthesist.80470172.eng.abstr-s7-r2-t3.1-t6.1",
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},
{
"id": "DerAnaesthesist.80470172.eng.abstr-s7-r4-t3.1-t1.1",
"type": "measures",
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},
{
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},
{
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},
{
"id": "DerAnaesthesist.80470172.eng.abstr-s10-r1-t7.1-t4.1",
"type": "interacts_with",
"arg1_id": "DerAnaesthesist.80470172.eng.abstr-s10-t7",
"arg2_id": "DerAnaesthesist.80470172.eng.abstr-s11-t4",
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},
{
"id": "DerAnaesthesist.80470172.eng.abstr-s10-r2-t7.1-t1.1",
"type": "interacts_with",
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},
{
"id": "DerAnaesthesist.80470172.eng.abstr-s10-r3-t7.1-t3.1",
"type": "interacts_with",
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"arg2_id": "DerAnaesthesist.80470172.eng.abstr-s11-t3",
"normalized": []
},
{
"id": "DerAnaesthesist.80470172.eng.abstr-s10-r4-t7.1-t5.1",
"type": "interacts_with",
"arg1_id": "DerAnaesthesist.80470172.eng.abstr-s10-t7",
"arg2_id": "DerAnaesthesist.80470172.eng.abstr-s10-t5",
"normalized": []
},
{
"id": "DerAnaesthesist.80470172.eng.abstr-s10-r5-t7.1-t2.1",
"type": "interacts_with",
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},
{
"id": "DerAnaesthesist.80470172.eng.abstr-s11-r1-t1.1-t4.1",
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"normalized": []
},
{
"id": "DerAnaesthesist.80470172.eng.abstr-s11-r2-t4.1-t2.1",
"type": "occurs_in",
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},
{
"id": "DerAnaesthesist.80470172.eng.abstr-s11-r3-t1.1-t2.1",
"type": "affects",
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},
{
"id": "DerAnaesthesist.80470172.eng.abstr-s11-r4-t1.1-t4.1",
"type": "diagnoses",
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},
{
"id": "DerAnaesthesist.80470172.eng.abstr-s11-r5-t2.1-t4.1",
"type": "result_of",
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"arg2_id": "DerAnaesthesist.80470172.eng.abstr-s11-t4",
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},
{
"id": "DerAnaesthesist.80470172.eng.abstr-s11-r6-t4.1-t2.1",
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"arg2_id": "DerAnaesthesist.80470172.eng.abstr-s11-t2",
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}
] |
DerAnaesthesist.80470184.eng.abstr
|
DerAnaesthesist.80470184.eng.abstr
|
[
{
"id": "DerAnaesthesist.80470184.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The anaesthetic potency of the ( S ) -ketamine isomer is approximately double that of racemic ketamine . The aim of this study was to compare the recovery of cerebral function after a bolus of 1,3 mg/kg racemic ketamine or 0.65 mg/kg ( S ) -ketamine followed by continuous application of 4 or 2 mg/kgxh over 15 minutes ."
],
"offsets": [
[
0,
320
]
]
}
] |
[
{
"id": "DerAnaesthesist.80470184.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"anaesthetic"
],
"offsets": [
[
4,
15
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0002932"
}
]
},
{
"id": "DerAnaesthesist.80470184.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"-ketamine"
],
"offsets": [
[
37,
46
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0022614"
}
]
},
{
"id": "DerAnaesthesist.80470184.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"isomer"
],
"offsets": [
[
47,
53
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0022203"
}
]
},
{
"id": "DerAnaesthesist.80470184.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"ketamine"
],
"offsets": [
[
94,
102
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0022614"
}
]
},
{
"id": "DerAnaesthesist.80470184.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"aim"
],
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[
109,
112
]
],
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{
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"db_id": "C0108800"
}
]
},
{
"id": "DerAnaesthesist.80470184.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"function"
],
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[
167,
175
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0031843"
}
]
},
{
"id": "DerAnaesthesist.80470184.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"ketamine"
],
"offsets": [
[
211,
219
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0022614"
}
]
},
{
"id": "DerAnaesthesist.80470184.eng.abstr-s2-t4",
"type": "umlsterm",
"text": [
"-ketamine"
],
"offsets": [
[
240,
249
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0022614"
}
]
}
] |
[] |
[] |
[
{
"id": "DerAnaesthesist.80470184.eng.abstr-s1-r1-t4.1-t3.1",
"type": "affects",
"arg1_id": "DerAnaesthesist.80470184.eng.abstr-s2-t4",
"arg2_id": "DerAnaesthesist.80470184.eng.abstr-s2-t3",
"normalized": []
},
{
"id": "DerAnaesthesist.80470184.eng.abstr-s1-r2-t4.1-t2.1",
"type": "interacts_with",
"arg1_id": "DerAnaesthesist.80470184.eng.abstr-s2-t4",
"arg2_id": "DerAnaesthesist.80470184.eng.abstr-s2-t2",
"normalized": []
},
{
"id": "DerAnaesthesist.80470184.eng.abstr-s1-r3-t2.1-t3.1",
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},
{
"id": "DerAnaesthesist.80470184.eng.abstr-s1-r4-t1.1-t2.1",
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"normalized": []
},
{
"id": "DerAnaesthesist.80470184.eng.abstr-s1-r5-t4.1-t1.1",
"type": "interacts_with",
"arg1_id": "DerAnaesthesist.80470184.eng.abstr-s2-t4",
"arg2_id": "DerAnaesthesist.80470184.eng.abstr-s2-t1",
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},
{
"id": "DerAnaesthesist.80470184.eng.abstr-s1-r6-t1.1-t4.1",
"type": "interacts_with",
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"normalized": []
},
{
"id": "DerAnaesthesist.80470184.eng.abstr-s1-r7-t2.1-t4.1",
"type": "interacts_with",
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},
{
"id": "DerAnaesthesist.80470184.eng.abstr-s1-r8-t1.1-t3.1",
"type": "affects",
"arg1_id": "DerAnaesthesist.80470184.eng.abstr-s2-t1",
"arg2_id": "DerAnaesthesist.80470184.eng.abstr-s2-t3",
"normalized": []
},
{
"id": "DerAnaesthesist.80470184.eng.abstr-s1-r9-t2.1-t1.1",
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{
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},
{
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},
{
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},
{
"id": "DerAnaesthesist.80470184.eng.abstr-s2-r4-t4.1-t1.1",
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"arg2_id": "DerAnaesthesist.80470184.eng.abstr-s2-t1",
"normalized": []
},
{
"id": "DerAnaesthesist.80470184.eng.abstr-s2-r5-t4.1-t1.1",
"type": "affects",
"arg1_id": "DerAnaesthesist.80470184.eng.abstr-s2-t4",
"arg2_id": "DerAnaesthesist.80470184.eng.abstr-s2-t1",
"normalized": []
},
{
"id": "DerAnaesthesist.80470184.eng.abstr-s2-r6-t1.1-t4.1",
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"arg1_id": "DerAnaesthesist.80470184.eng.abstr-s2-t1",
"arg2_id": "DerAnaesthesist.80470184.eng.abstr-s2-t4",
"normalized": []
}
] |
DerAnaesthesist.80470193.eng.abstr
|
DerAnaesthesist.80470193.eng.abstr
|
[
{
"id": "DerAnaesthesist.80470193.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Acute renal failure is a common and severe complication in ICU . Renal laboratory examinations like creatinine and urea are late signs of renal dysfunction : Most of the functional abilities are reduced and there is no time for therapeutical interventions . The aim of this study was to find some earlier sensitive parameters of renal dysfunction and the order of appearance , the cause of acute renal failure and the value of the measured parameters ."
],
"offsets": [
[
0,
452
]
]
}
] |
[
{
"id": "DerAnaesthesist.80470193.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"complication"
],
"offsets": [
[
43,
55
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0009566"
}
]
},
{
"id": "DerAnaesthesist.80470193.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"ICU"
],
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[
59,
62
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0021708"
}
]
},
{
"id": "DerAnaesthesist.80470193.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"renal failure"
],
"offsets": [
[
6,
19
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0035078"
}
]
},
{
"id": "DerAnaesthesist.80470193.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"Acute renal failure"
],
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0,
19
]
],
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]
},
{
"id": "DerAnaesthesist.80470193.eng.abstr-s2-t1",
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"laboratory"
],
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[
71,
81
]
],
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{
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"db_id": "C0022877"
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]
},
{
"id": "DerAnaesthesist.80470193.eng.abstr-s2-t2",
"type": "umlsterm",
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"creatinine"
],
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[
100,
110
]
],
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{
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"db_id": "C0010294"
}
]
},
{
"id": "DerAnaesthesist.80470193.eng.abstr-s2-t3",
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"text": [
"urea"
],
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115,
119
]
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}
]
},
{
"id": "DerAnaesthesist.80470193.eng.abstr-s2-t4",
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"signs"
],
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129,
134
]
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}
]
},
{
"id": "DerAnaesthesist.80470193.eng.abstr-s2-t5",
"type": "umlsterm",
"text": [
"dysfunction"
],
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[
144,
155
]
],
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{
"db_name": "UMLS",
"db_id": "C0031847"
}
]
},
{
"id": "DerAnaesthesist.80470193.eng.abstr-s2-t6",
"type": "umlsterm",
"text": [
"abilities"
],
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[
181,
190
]
],
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{
"db_name": "UMLS",
"db_id": "C0085732"
}
]
},
{
"id": "DerAnaesthesist.80470193.eng.abstr-s2-t7",
"type": "umlsterm",
"text": [
"time"
],
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[
219,
223
]
],
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{
"db_name": "UMLS",
"db_id": "C0040223"
}
]
},
{
"id": "DerAnaesthesist.80470193.eng.abstr-s2-t8",
"type": "umlsterm",
"text": [
"functional abilities"
],
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[
170,
190
]
],
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{
"db_name": "UMLS",
"db_id": "C0001288"
}
]
},
{
"id": "DerAnaesthesist.80470193.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"aim"
],
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[
262,
265
]
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{
"db_name": "UMLS",
"db_id": "C0108800"
}
]
},
{
"id": "DerAnaesthesist.80470193.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"dysfunction"
],
"offsets": [
[
335,
346
]
],
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{
"db_name": "UMLS",
"db_id": "C0031847"
}
]
},
{
"id": "DerAnaesthesist.80470193.eng.abstr-s3-t3",
"type": "umlsterm",
"text": [
"cause"
],
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[
381,
386
]
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"db_id": "C0015127"
}
]
},
{
"id": "DerAnaesthesist.80470193.eng.abstr-s3-t4",
"type": "umlsterm",
"text": [
"value"
],
"offsets": [
[
418,
423
]
],
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{
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}
]
},
{
"id": "DerAnaesthesist.80470193.eng.abstr-s3-t5",
"type": "umlsterm",
"text": [
"renal failure"
],
"offsets": [
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396,
409
]
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"db_id": "C0035078"
}
]
},
{
"id": "DerAnaesthesist.80470193.eng.abstr-s3-t6",
"type": "umlsterm",
"text": [
"acute renal failure"
],
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[
390,
409
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0022660"
}
]
}
] |
[] |
[] |
[
{
"id": "DerAnaesthesist.80470193.eng.abstr-s1-r1-t1.1-t3.1",
"type": "causes",
"arg1_id": "DerAnaesthesist.80470193.eng.abstr-s3-t1",
"arg2_id": "DerAnaesthesist.80470193.eng.abstr-s3-t3",
"normalized": []
},
{
"id": "DerAnaesthesist.80470193.eng.abstr-s1-r2-t4.1-t1.1",
"type": "degree_of",
"arg1_id": "DerAnaesthesist.80470193.eng.abstr-s3-t4",
"arg2_id": "DerAnaesthesist.80470193.eng.abstr-s3-t1",
"normalized": []
},
{
"id": "DerAnaesthesist.80470193.eng.abstr-s1-r3-t1.1-t4.1",
"type": "degree_of",
"arg1_id": "DerAnaesthesist.80470193.eng.abstr-s3-t1",
"arg2_id": "DerAnaesthesist.80470193.eng.abstr-s3-t4",
"normalized": []
},
{
"id": "DerAnaesthesist.80470193.eng.abstr-s1-r4-t1.1-t3.1",
"type": "degree_of",
"arg1_id": "DerAnaesthesist.80470193.eng.abstr-s3-t1",
"arg2_id": "DerAnaesthesist.80470193.eng.abstr-s3-t3",
"normalized": []
},
{
"id": "DerAnaesthesist.80470193.eng.abstr-s1-r5-t1.1-t4.1",
"type": "causes",
"arg1_id": "DerAnaesthesist.80470193.eng.abstr-s3-t1",
"arg2_id": "DerAnaesthesist.80470193.eng.abstr-s3-t4",
"normalized": []
},
{
"id": "DerAnaesthesist.80470193.eng.abstr-s1-r6-t3.1-t1.1",
"type": "degree_of",
"arg1_id": "DerAnaesthesist.80470193.eng.abstr-s3-t3",
"arg2_id": "DerAnaesthesist.80470193.eng.abstr-s3-t1",
"normalized": []
},
{
"id": "DerAnaesthesist.80470193.eng.abstr-s2-r1-t8.1-t3.1",
"type": "uses",
"arg1_id": "DerAnaesthesist.80470193.eng.abstr-s2-t8",
"arg2_id": "DerAnaesthesist.80470193.eng.abstr-s3-t3",
"normalized": []
},
{
"id": "DerAnaesthesist.80470193.eng.abstr-s2-r2-t4.1-t6.1",
"type": "evaluation_of",
"arg1_id": "DerAnaesthesist.80470193.eng.abstr-s3-t4",
"arg2_id": "DerAnaesthesist.80470193.eng.abstr-s3-t6",
"normalized": []
},
{
"id": "DerAnaesthesist.80470193.eng.abstr-s2-r3-t3.1-t4.1",
"type": "treats",
"arg1_id": "DerAnaesthesist.80470193.eng.abstr-s3-t3",
"arg2_id": "DerAnaesthesist.80470193.eng.abstr-s3-t4",
"normalized": []
},
{
"id": "DerAnaesthesist.80470193.eng.abstr-s2-r4-t1.1-t8.1",
"type": "carries_out",
"arg1_id": "DerAnaesthesist.80470193.eng.abstr-s3-t1",
"arg2_id": "DerAnaesthesist.80470193.eng.abstr-s2-t8",
"normalized": []
},
{
"id": "DerAnaesthesist.80470193.eng.abstr-s2-r5-t3.1-t2.1",
"type": "interacts_with",
"arg1_id": "DerAnaesthesist.80470193.eng.abstr-s3-t3",
"arg2_id": "DerAnaesthesist.80470193.eng.abstr-s3-t2",
"normalized": []
},
{
"id": "DerAnaesthesist.80470193.eng.abstr-s2-r6-t2.1-t3.1",
"type": "interacts_with",
"arg1_id": "DerAnaesthesist.80470193.eng.abstr-s3-t2",
"arg2_id": "DerAnaesthesist.80470193.eng.abstr-s3-t3",
"normalized": []
},
{
"id": "DerAnaesthesist.80470193.eng.abstr-s2-r7-t8.1-t1.1",
"type": "uses",
"arg1_id": "DerAnaesthesist.80470193.eng.abstr-s2-t8",
"arg2_id": "DerAnaesthesist.80470193.eng.abstr-s3-t1",
"normalized": []
},
{
"id": "DerAnaesthesist.80470193.eng.abstr-s2-r8-t8.1-t4.1",
"type": "treats",
"arg1_id": "DerAnaesthesist.80470193.eng.abstr-s2-t8",
"arg2_id": "DerAnaesthesist.80470193.eng.abstr-s3-t4",
"normalized": []
},
{
"id": "DerAnaesthesist.80470193.eng.abstr-s3-r1-t1.1-t6.1",
"type": "indicates",
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"arg2_id": "DerAnaesthesist.80470193.eng.abstr-s3-t6",
"normalized": []
},
{
"id": "DerAnaesthesist.80470193.eng.abstr-s3-r2-t6.1-t1.1",
"type": "produces",
"arg1_id": "DerAnaesthesist.80470193.eng.abstr-s3-t6",
"arg2_id": "DerAnaesthesist.80470193.eng.abstr-s3-t1",
"normalized": []
},
{
"id": "DerAnaesthesist.80470193.eng.abstr-s3-r3-t1.1-t6.1",
"type": "affects",
"arg1_id": "DerAnaesthesist.80470193.eng.abstr-s3-t1",
"arg2_id": "DerAnaesthesist.80470193.eng.abstr-s3-t6",
"normalized": []
}
] |
DerAnaesthesist.80470202.eng.abstr
|
DerAnaesthesist.80470202.eng.abstr
|
[
{
"id": "DerAnaesthesist.80470202.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Epidural anaesthesia is extremely useful in providing postoperative analgesia for children after surgery of the lower body . Although results on early pharmacokinetics in children have previously been reported , no data are available on the long-term effects of epidural anaesthesia . The aim of this investigation was the assessment of plasma bupivacaine levels in children with continuous epidural anaesthesia in the postoperative period . A catheter with an outer diameter of 0.63 mm was inserted through a 19G Tuohy cannula into the epidural space . A maximum dose of 0.4 mg/kg/h bupivacaine was administered for continuous epidural infusion . Careful monitoring was performed to detect early signs of local anaesthetic intoxication . Two milliliters of blood were obtained in each patient per day and nepholometric serum measurement were performed to determine 1-acid glycoprotein and albumin levels . Bupivacaine plasma concentrations were assessed according to the method described by Sattler et al. [ 25 ] . Ten children were included in the investigation . The measured albumin and 1-acid glycoprotein concentrations were within the range described by other investigators . At the onset of pain therapy maximum levels of 0.5 µg/ml where recorded after a loading dose of bupivacaine and levels of up to 2.2 µg/ml were achieved following continuous infusion . There were no neurologic complications or signs of lokal anesthetic intoxication . In conclusion our results show that a dose of up to 0.4 mg/kg/h bupivacaine during continuous epidural infusion is not associated with toxic complications . Careful monitoring of the children by experienced staff is mandatory ."
],
"offsets": [
[
0,
1677
]
]
}
] |
[
{
"id": "DerAnaesthesist.80470202.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"postoperative"
],
"offsets": [
[
54,
67
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0032790"
}
]
},
{
"id": "DerAnaesthesist.80470202.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"analgesia"
],
"offsets": [
[
68,
77
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0002766"
}
]
},
{
"id": "DerAnaesthesist.80470202.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"children"
],
"offsets": [
[
82,
90
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0008059"
}
]
},
{
"id": "DerAnaesthesist.80470202.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"surgery"
],
"offsets": [
[
97,
104
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0038894"
},
{
"db_name": "UMLS",
"db_id": "C0038895"
}
]
},
{
"id": "DerAnaesthesist.80470202.eng.abstr-s1-t5",
"type": "umlsterm",
"text": [
"Epidural anaesthesia"
],
"offsets": [
[
0,
20
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0002913"
}
]
},
{
"id": "DerAnaesthesist.80470202.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"pharmacokinetics"
],
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[
151,
167
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0031327"
},
{
"db_name": "UMLS",
"db_id": "C0031328"
}
]
},
{
"id": "DerAnaesthesist.80470202.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"children"
],
"offsets": [
[
171,
179
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0008059"
}
]
},
{
"id": "DerAnaesthesist.80470202.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"long-term effects"
],
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[
241,
258
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0023983"
}
]
},
{
"id": "DerAnaesthesist.80470202.eng.abstr-s2-t4",
"type": "umlsterm",
"text": [
"epidural anaesthesia"
],
"offsets": [
[
262,
282
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0002913"
}
]
},
{
"id": "DerAnaesthesist.80470202.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"aim"
],
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[
289,
292
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0108800"
}
]
},
{
"id": "DerAnaesthesist.80470202.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"assessment"
],
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[
323,
333
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0028708"
}
]
},
{
"id": "DerAnaesthesist.80470202.eng.abstr-s3-t3",
"type": "umlsterm",
"text": [
"plasma"
],
"offsets": [
[
337,
343
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0032105"
}
]
},
{
"id": "DerAnaesthesist.80470202.eng.abstr-s3-t4",
"type": "umlsterm",
"text": [
"bupivacaine"
],
"offsets": [
[
344,
355
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0006400"
}
]
},
{
"id": "DerAnaesthesist.80470202.eng.abstr-s3-t5",
"type": "umlsterm",
"text": [
"children"
],
"offsets": [
[
366,
374
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0008059"
}
]
},
{
"id": "DerAnaesthesist.80470202.eng.abstr-s3-t6",
"type": "umlsterm",
"text": [
"postoperative"
],
"offsets": [
[
419,
432
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0032790"
}
]
},
{
"id": "DerAnaesthesist.80470202.eng.abstr-s3-t7",
"type": "umlsterm",
"text": [
"period"
],
"offsets": [
[
433,
439
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0025344"
}
]
},
{
"id": "DerAnaesthesist.80470202.eng.abstr-s3-t8",
"type": "umlsterm",
"text": [
"epidural anaesthesia"
],
"offsets": [
[
391,
411
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0002913"
}
]
},
{
"id": "DerAnaesthesist.80470202.eng.abstr-s3-t9",
"type": "umlsterm",
"text": [
"postoperative period"
],
"offsets": [
[
419,
439
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0032790"
}
]
},
{
"id": "DerAnaesthesist.80470202.eng.abstr-s4-t1",
"type": "umlsterm",
"text": [
"catheter"
],
"offsets": [
[
444,
452
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0085590"
}
]
},
{
"id": "DerAnaesthesist.80470202.eng.abstr-s4-t2",
"type": "umlsterm",
"text": [
"cannula"
],
"offsets": [
[
520,
527
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0520453"
}
]
},
{
"id": "DerAnaesthesist.80470202.eng.abstr-s4-t3",
"type": "umlsterm",
"text": [
"epidural space"
],
"offsets": [
[
537,
551
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0014537"
}
]
},
{
"id": "DerAnaesthesist.80470202.eng.abstr-s5-t1",
"type": "umlsterm",
"text": [
"bupivacaine"
],
"offsets": [
[
584,
595
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0006400"
}
]
},
{
"id": "DerAnaesthesist.80470202.eng.abstr-s6-t1",
"type": "umlsterm",
"text": [
"signs"
],
"offsets": [
[
697,
702
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0220912"
}
]
},
{
"id": "DerAnaesthesist.80470202.eng.abstr-s6-t2",
"type": "umlsterm",
"text": [
"anaesthetic"
],
"offsets": [
[
712,
723
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0002932"
}
]
},
{
"id": "DerAnaesthesist.80470202.eng.abstr-s6-t3",
"type": "umlsterm",
"text": [
"intoxication"
],
"offsets": [
[
724,
736
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0032344"
},
{
"db_name": "UMLS",
"db_id": "C0728899"
}
]
},
{
"id": "DerAnaesthesist.80470202.eng.abstr-s6-t4",
"type": "umlsterm",
"text": [
"local anaesthetic"
],
"offsets": [
[
706,
723
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0002934"
},
{
"db_name": "UMLS",
"db_id": "C0002921"
}
]
},
{
"id": "DerAnaesthesist.80470202.eng.abstr-s7-t1",
"type": "umlsterm",
"text": [
"blood"
],
"offsets": [
[
758,
763
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0005767"
},
{
"db_name": "UMLS",
"db_id": "C0005768"
},
{
"db_name": "UMLS",
"db_id": "C0005835"
}
]
},
{
"id": "DerAnaesthesist.80470202.eng.abstr-s7-t2",
"type": "umlsterm",
"text": [
"patient"
],
"offsets": [
[
786,
793
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0030705"
}
]
},
{
"id": "DerAnaesthesist.80470202.eng.abstr-s7-t3",
"type": "umlsterm",
"text": [
"nepholometric"
],
"offsets": [
[
806,
819
]
],
"normalized": [
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] |
DerAnaesthesist.80470209.eng.abstr
|
DerAnaesthesist.80470209.eng.abstr
|
[
{
"id": "DerAnaesthesist.80470209.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Despite advances and technical developments in the area of intensive care medicine is has not been possible to lower the mortality of patients with pulmonary insufficiency . Therefore , alternative ventilation strategies have been developed and applied . One of these ventilation techniques is superimposed high-frequency jet ventilation ( SHFJV ) . For optimal application of SHFJV we designed a special jet-adapter . Methods : This jet-adapter made of plastic consists of a T-piece and four central , small-bore cannulas and can be connected to any commercially available endotracheal tube . Therefore , it does not require reintubation with an endotracheal jet tube when beginning SHFJV . The simultaneous high-frequency and low-frequency jet ventilation is performed over two jet-nozzles that have been designed according to optimal flow dynamic measurements . Two further cannulas are used for continuous airway pressure monitoring and humidification of the applied gases . A pre-warmed and humidified bias flow with exactly defined oxygen concentration is led through the cross-part of the T-piece for gas entrainment . Additionally , the cross-part contains a port that can be opened for endotracheal suctioning or bronchoscopy and makes disconnection of the jet adapter from the endotracheal tube for either purpose unnecessary . Conclusion : The jet adapter can be used : ( 1 ) to apply SHFJV ; ( 2 ) to measure airway pressures continuously ; ( 3 ) to humidify and warm inspired gases ; ( 4 ) to administer medications or add nitrous oxide by the inspiratory route , enabling combination with new therapeutic possibilities in the management of patients with severe ARDS ."
],
"offsets": [
[
0,
1681
]
]
}
] |
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31,
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DerAnaesthesist.80470229.eng.abstr
|
DerAnaesthesist.80470229.eng.abstr
|
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],
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0,
549
]
]
}
] |
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],
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"children"
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"id": "DerAnaesthesist.80470229.eng.abstr-s3-t5",
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},
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"id": "DerAnaesthesist.80470229.eng.abstr-s3-t6",
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"id": "DerAnaesthesist.80470229.eng.abstr-s3-t10",
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"normalized": [
{
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"db_id": "C0011000"
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] |
[] |
[] |
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DerAnaesthesist.80470238.eng.abstr
|
DerAnaesthesist.80470238.eng.abstr
|
[
{
"id": "DerAnaesthesist.80470238.eng.abstr-passage-0",
"type": "abstract",
"text": [
"We report the case of a 3-year-old boy , who received long-term parent-controlled analgesia after traumatic amputation of one leg . He underwent surgery 17 times for a period of 25 days . Parent-controlled analgesia was started four days after admission because analgesia with non-opioid analgetics ( acetaminophen ) proved to be insuffient . The pump was set to a bolus-dose of 23 µg kg-1 piritramide ( dipidolor ) and a lockout interval of 10 minutes . Permitted maximum cumulative dose in four hours was 5 mg piritramide . There was no continuous infusion of opioid . PCA and possible adverse effects were explained to the mother . A monitoring regimen was used to assess efficacy ( pain intensity estimated by the mother ) , adverse effects ( sedation score , occurrence of nausea and vomiting ) and piritramide consumption . For fear of side effects opioid administration was insufficient in the beginning . After three days the mother used the PCA effectively and no additional analgesic medication was required . Nausea or other side effects were not observed . After seven days opioid consumption nearly doubled . Apart from tolerance , this might have resulted from the mother's caution in the first days . After 17 days the PCA was discontinued . Oral analgetics ( tramadol ) controlled the pain adequately . Management of postoperative pain in childrens is difficult and too often insufficient . PCA is a safe and effective method of providing postoperative pain relief . Feasability was shown in adolescents and , more recently , in children aged five years and over . Only few reports are available describing long term use of PCA in children younger than five years . Our case suggests that PCA may also be used effectively and safely in children younger than five years , if experienced staff , a monitoring regimen and cooperative and well instructed parents are available ."
],
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[
0,
1890
]
]
}
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DerAnaesthesist.80470269.eng.abstr
|
DerAnaesthesist.80470269.eng.abstr
|
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{
"id": "DerAnaesthesist.80470269.eng.abstr-passage-0",
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"text": [
"Hyperbaric Oxygen ( HBO ) therapy is a kind of medical treatment in which a patient breathes 100% of oxygen inside a pressure chamber while the pressure of the chamber is increased to a point higher than sea level pressure . It is strongly based on clearly defined physical laws and physiological regularities . For the clinical use of HBO therapy , according to international recommendations , there are several commonly accepted indications in which HBO either is the only causative life-saving kind of treatment , or is an essential and oftenly decisive component of a comprehensive interdisciplinary intensive care therapy . Among potential adverse effects , barotrauma of the lungs and especially oxygen toxicity to the central nervous system have to be mentioned . Clinical use of HBO therefore requires special knowledge of its effects , risks , and adverse effects , a clear and distinct indication , and the ability and skills to keep complications under control by means of intensive care or emergency medical measures . The clinical use of hyperbaric oxygen with its interdisciplinary-like character of emergency medicine or intensive care therapy therefore should be an additional , most interesting field of activity for the anaesthesiologist ."
],
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0,
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]
}
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] |
DerAnaesthesist.80470295.eng.abstr
|
DerAnaesthesist.80470295.eng.abstr
|
[
{
"id": "DerAnaesthesist.80470295.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Turnaround time for analysis of prothrombin time ( PT ) and activated partial thromboplastin time ( APTT ) by standard laboratory methods ranges between 40 min and several hours . The delay in obtaining the test results limits their clinical utility for treatment of perioperative coagulation disorders and adequate anti-coagulation therapy . In this study , we compared on-site coagulation testing ( OCT ) of whole blood , which takes about 3 min , with standard laboratory plasma coagulation tests by our institutional laboratory ( LAB ) to assess the accuracy of the OCT in a clinical setting ( abdominal and postcardiac surgery ) ."
],
"offsets": [
[
0,
635
]
]
}
] |
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DerAnaesthesist.80470303.eng.abstr
|
DerAnaesthesist.80470303.eng.abstr
|
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],
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0,
399
]
]
}
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DerAnaesthesist.80470311.eng.abstr
|
DerAnaesthesist.80470311.eng.abstr
|
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],
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0,
276
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]
}
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"id": "DerAnaesthesist.80470311.eng.abstr-s1-t7",
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"id": "DerAnaesthesist.80470311.eng.abstr-s1-t9",
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75,
89
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},
{
"id": "DerAnaesthesist.80470311.eng.abstr-s1-t10",
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114,
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},
{
"id": "DerAnaesthesist.80470311.eng.abstr-s1-t11",
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226,
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{
"id": "DerAnaesthesist.80470311.eng.abstr-s1-t14",
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114,
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] |
[] |
[] |
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DerAnaesthesist.80470320.eng.abstr
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DerAnaesthesist.80470320.eng.abstr
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"Early defibrillation is the standard of care for patients with ventricular fibrillation ( VF ) and pulseless ventricular tachycardia ( VT ) . Technical developments aim at further miniaturization and simplification of defibrillators as well as adaptation of energy requirements to the patient's needs . Implantable Cardioverter-Defibrillators ( ICD ) and automated external defibrillators ( AED ) are based upon the same technology . Both devices analyze the ECG signal internally , followed by a \" shock \" or \" no shock \" decision . Use of automated devices is the prerequisite for defibrillation by non-physicians . Chest impedance measurements and use of alternative shock waveforms , such as biphasic , aim at adaptation of energy or current to the patient's individual needs and avoid application of unnecessarily high amounts of energy to the myocardium . Calculation of median frequency is a non-invasive method for analyzing the heart's metabolic and electrical state . It helps to determine the optimal moment for defibrillation during cardiopulmonary resuscitation ( CPR ) . Developments concerning the structure of in-hospital emergency systems or pre-hospital emergency medical services ( EMS ) aim at further reductions in time from collapse of a patient until first defibrillation . Such developments include early defibrillation programs for emergency medical technicians ( EMT ) , nurses , and fire or police department first responders as well as wide distribution of easy-to-operate defibrillators in public areas , as discussed during the American Heart Association's Public Access Defibrillation conferences . All programs of that kind have to be organized and supervised by a physician who is responsible for training and supervision of the personnel involved ."
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] |
DerAnaesthesist.80470330.eng.abstr
|
DerAnaesthesist.80470330.eng.abstr
|
[
{
"id": "DerAnaesthesist.80470330.eng.abstr-passage-0",
"type": "abstract",
"text": [
"In addition to renal elimination and gastrointestinal metabolism ( amylase ; splenic and hepatic dextranase ) colloid plasma solutions like dextran and hydroxyethyl starch deposit in tissues , especially in the reticuloendothelial system ( RES ) . This tissue storage is limited in time ( weeks to months ) , is influenced by the employed solution and other factors ( lysosomes ) and has usually no clinical importance ( no RES blockade ) . We report here a case study of a patient with sepsis ( lung , liver and kidney failure ) who had an overload of the RES with colloids while being treated with dextran ( molecular weight 40000 and 70000 daltons ) and hydroxyethyl starch ( mw 450000 daltons , molar substitution 0,7 ) ."
],
"offsets": [
[
0,
725
]
]
}
] |
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"metabolism"
],
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54,
64
]
],
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}
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{
"id": "DerAnaesthesist.80470330.eng.abstr-s1-t2",
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"amylase"
],
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67,
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]
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"db_id": "C0002712"
}
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},
{
"id": "DerAnaesthesist.80470330.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"dextranase"
],
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[
97,
107
]
],
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{
"db_name": "UMLS",
"db_id": "C0011805"
}
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},
{
"id": "DerAnaesthesist.80470330.eng.abstr-s1-t4",
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"colloid"
],
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110,
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]
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124
]
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"id": "DerAnaesthesist.80470330.eng.abstr-s1-t8",
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],
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165,
171
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"id": "DerAnaesthesist.80470330.eng.abstr-s1-t9",
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"tissues"
],
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183,
190
]
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"db_id": "C0040300"
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},
{
"id": "DerAnaesthesist.80470330.eng.abstr-s1-t10",
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"hydroxyethyl starch"
],
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152,
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]
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{
"id": "DerAnaesthesist.80470330.eng.abstr-s2-t1",
"type": "umlsterm",
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"tissue"
],
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253,
259
]
],
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"time"
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{
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},
{
"id": "DerAnaesthesist.80470330.eng.abstr-s3-r18-t11.1-t4.1",
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DerAnaesthesist.80470368.eng.abstr
|
DerAnaesthesist.80470368.eng.abstr
|
[
{
"id": "DerAnaesthesist.80470368.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Abstract Monitoring has made great strides in the last half century . It enables us to titrate drugs to the desired effect , warns us of impending danger , and helps with the diagnosis of problems confronting our patients . Beyond that it has enormously increased our understanding of anesthetic pathophysiology . Modern monitors , however , are still focused on single variables ; they do not provide the panoramic view offered by our senses . They do not give data on the patient ? s appearance , movement , or position . The clinician incorporates that type of information with the data provided by the monitors and melds that with a much richer information about the system in which he operates , the colleagues with whom he works and the circumstances that affect his patient . Even though we appreciate the importance of that wealth of information , we lack scientific tools to measure its value ."
],
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[
0,
903
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]
}
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{
"id": "DerAnaesthesist.80470368.eng.abstr-s1-t1",
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"id": "DerAnaesthesist.80470368.eng.abstr-s1-t2",
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"Monitoring"
],
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9,
19
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],
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}
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{
"id": "DerAnaesthesist.80470368.eng.abstr-s2-t1",
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"drugs"
],
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[
95,
100
]
],
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},
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"id": "DerAnaesthesist.80470368.eng.abstr-s2-t2",
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175,
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"patients"
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213,
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268,
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"id": "DerAnaesthesist.80470368.eng.abstr-s3-t2",
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"id": "DerAnaesthesist.80470368.eng.abstr-s3-t3",
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296,
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"id": "DerAnaesthesist.80470368.eng.abstr-s4-t1",
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"monitors"
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321,
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}
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{
"id": "DerAnaesthesist.80470368.eng.abstr-s4-t2",
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"id": "DerAnaesthesist.80470368.eng.abstr-s5-t1",
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"id": "DerAnaesthesist.80470368.eng.abstr-s6-t1",
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"movement"
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"id": "DerAnaesthesist.80470368.eng.abstr-s7-t1",
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606,
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"id": "DerAnaesthesist.80470368.eng.abstr-s7-t2",
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"value"
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{
"db_name": "UMLS",
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}
] |
[] |
[] |
[
{
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"type": "affects",
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"id": "DerAnaesthesist.80470368.eng.abstr-s2-r2-t2.1-t1.1",
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"id": "DerAnaesthesist.80470368.eng.abstr-s3-r1-t3.1-t1.1",
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"arg2_id": "DerAnaesthesist.80470368.eng.abstr-s8-t1",
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}
] |
DerAnaesthesist.80470373.eng.abstr
|
DerAnaesthesist.80470373.eng.abstr
|
[
{
"id": "DerAnaesthesist.80470373.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Objective : The aim of this study is to examine whether a routine preoperative ECG is necessary in children to assess the risks in anaesthesia and surgery ."
],
"offsets": [
[
0,
156
]
]
}
] |
[
{
"id": "DerAnaesthesist.80470373.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"Objective"
],
"offsets": [
[
0,
9
]
],
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{
"db_name": "UMLS",
"db_id": "C0018017"
}
]
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{
"id": "DerAnaesthesist.80470373.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"aim"
],
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[
16,
19
]
],
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{
"db_name": "UMLS",
"db_id": "C0108800"
}
]
},
{
"id": "DerAnaesthesist.80470373.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"ECG"
],
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[
79,
82
]
],
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{
"db_name": "UMLS",
"db_id": "C0013798"
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]
},
{
"id": "DerAnaesthesist.80470373.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"children"
],
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[
99,
107
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],
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}
]
},
{
"id": "DerAnaesthesist.80470373.eng.abstr-s1-t5",
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"risks"
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122,
127
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"db_id": "C0035647"
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},
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"id": "DerAnaesthesist.80470373.eng.abstr-s1-t6",
"type": "umlsterm",
"text": [
"surgery"
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[
147,
154
]
],
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{
"db_name": "UMLS",
"db_id": "C0038894"
},
{
"db_name": "UMLS",
"db_id": "C0038895"
}
]
}
] |
[] |
[] |
[
{
"id": "DerAnaesthesist.80470373.eng.abstr-s1-r1-t4.1-t2.1",
"type": "performs",
"arg1_id": "DerAnaesthesist.80470373.eng.abstr-s1-t4",
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"normalized": []
},
{
"id": "DerAnaesthesist.80470373.eng.abstr-s1-r2-t2.1-t6.1",
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"arg1_id": "DerAnaesthesist.80470373.eng.abstr-s1-t2",
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},
{
"id": "DerAnaesthesist.80470373.eng.abstr-s1-r3-t1.1-t2.1",
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},
{
"id": "DerAnaesthesist.80470373.eng.abstr-s1-r5-t4.1-t6.1",
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"arg2_id": "DerAnaesthesist.80470373.eng.abstr-s1-t6",
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},
{
"id": "DerAnaesthesist.80470373.eng.abstr-s1-r6-t5.1-t2.1",
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},
{
"id": "DerAnaesthesist.80470373.eng.abstr-s1-r7-t4.1-t1.1",
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},
{
"id": "DerAnaesthesist.80470373.eng.abstr-s1-r8-t2.1-t6.1",
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"normalized": []
},
{
"id": "DerAnaesthesist.80470373.eng.abstr-s1-r9-t1.1-t6.1",
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},
{
"id": "DerAnaesthesist.80470373.eng.abstr-s1-r10-t5.1-t6.1",
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},
{
"id": "DerAnaesthesist.80470373.eng.abstr-s1-r11-t2.1-t5.1",
"type": "measures",
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"arg2_id": "DerAnaesthesist.80470373.eng.abstr-s1-t5",
"normalized": []
}
] |
DerAnaesthesist.80470379.eng.abstr
|
DerAnaesthesist.80470379.eng.abstr
|
[
{
"id": "DerAnaesthesist.80470379.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Objective : Anaesthetic agents are believed to have an adverse effect on human immune defense mechanisms . We investigated changes in peripheral immune cell numbers such as natural killer ( NK ) cells , B cells and T lymphocyte subpopulations ( CD4+ and CD8+ cells ) and differences in cytokine production after stimulation with different mitogens before and during narcosis ."
],
"offsets": [
[
0,
376
]
]
}
] |
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{
"id": "DerAnaesthesist.80470379.eng.abstr-s1-t1",
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"db_id": "C0018017"
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{
"id": "DerAnaesthesist.80470379.eng.abstr-s1-t2",
"type": "umlsterm",
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],
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12,
23
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],
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"db_name": "UMLS",
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}
]
},
{
"id": "DerAnaesthesist.80470379.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"human"
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73,
78
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],
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"db_id": "C0020114"
}
]
},
{
"id": "DerAnaesthesist.80470379.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"adverse effect"
],
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[
55,
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],
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"db_id": "C0001688"
}
]
},
{
"id": "DerAnaesthesist.80470379.eng.abstr-s1-t5",
"type": "umlsterm",
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"defense mechanisms"
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"db_id": "C0011142"
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},
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"id": "DerAnaesthesist.80470379.eng.abstr-s2-t1",
"type": "umlsterm",
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"cell"
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152,
156
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"db_id": "C0007634"
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]
},
{
"id": "DerAnaesthesist.80470379.eng.abstr-s2-t2",
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"cells"
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[
195,
200
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]
},
{
"id": "DerAnaesthesist.80470379.eng.abstr-s2-t3",
"type": "umlsterm",
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"cells"
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205,
210
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}
]
},
{
"id": "DerAnaesthesist.80470379.eng.abstr-s2-t4",
"type": "umlsterm",
"text": [
"lymphocyte"
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217,
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"db_id": "C0024264"
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[] |
[] |
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DerAnaesthesist.80470387.eng.abstr
|
DerAnaesthesist.80470387.eng.abstr
|
[
{
"id": "DerAnaesthesist.80470387.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The goal of this prospective , randomised and double-blind pilot-study was to investigate the analgesic potency and the side-effects of tramadol enantiomers in clinical practice . One hundred patients recovering from orthopaedic surgery with a postoperative pain intensity of more than 50 on a visual analogue scale 0-100 mm ( Table 1 ) were recruited for the study . They were treated in a randomised , double-blind way with a maximal dose of 150 mg i.v. ( + ) - , ( - ) -tramadol , racemate , or 15 mg i.v. morphine or saline in the placebo group ( 5 groups , 20 patients each ) . The primary criterium of efficacy was the number of responders defined as patients with a pain reduction of at least 20 on VAS after 40 min . In case of pain , responders were allowed to continue with the double-blind drug up to six hours . The non-responders were treated with morphine as the rescue analgesic . The secondary criterium was the incidence and severity of side-effects . Six patients terminated the study prematurely . One patient was excluded because of an allergic reaction to morphine , one patient could not be treated sufficiently with morphine , four were excluded because of protocol violations . There were 8 responders in the ( + ) -tramadol-, 6 in the ( - ) -tramadol- and 6 in the racemate group , 16* ( P 0,05 ) in the morphine group , and 5 in the placebo group . Pain intensity after 40 min was reduced by 20 ( p 0,05 ) , 17 ( p 0,05 ) , 17 ( p 0,05 ) , 36 ( p 0,01 vs placebo , p 0,05 vs ( + ) - , ( - ) -tramadol , and racemate group ) and 5 mm on the VAS in the ( + ) - , ( - ) - , ( +/-)-tramadol-, morphine- and placebo-group , respectively . Thirty eight adverse events like nausea , vomiting , PCO2-increase, and urinary retention occurred in 20 patients , most frequently in the ( + ) -tramadol- and morphine group . Sedation was significantly less profound in the ( - ) -tramadol group 1-4 h postoperatively . There were no side-effect in the tramadol racemate group . The enantiomers were equal to the racemate in analgesic potency , but inferior by far to morphine . They showed more adverse events and , hence , can not be preferred to the racemate in postoperative pain therapy ."
],
"offsets": [
[
0,
2204
]
]
}
] |
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DerAnaesthesist.80470400.eng.abstr
|
DerAnaesthesist.80470400.eng.abstr
|
[
{
"id": "DerAnaesthesist.80470400.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Prehospital blood gas analysis is a new method in out-of-hospital emergency care . In a prospective pilot study we evaluated the feasibility of prehospital compensation of severe acidosis relying on different monitoring systems to evaluate patients oxygen , carbon dioxide or acid-base status , respectively . Methods : With the help of arterial blood gas checks taken at the site of the emergency , the acid base status of patients undergoing out of hospital cardiopulmonary resuscitation was analysed . The values derived from the first arterial puncture were used to determine the presence and the type of acidosis . The data of the arterial blood gas checks were set into relation with the time elapsed since the beginning of resuscitation and they were compared with end-tidal CO2. Results : During the observation period 26 blood gas analyses from patients who had out-of-hospital resuscitation because of cardiac arrest were done . Twenty three patients had severe acidosis ( pH range 6.9 to 7.31 ) , one had alkalosis ( pH 7.51 ) . Only two had an arterial pH within normal range . The pCO2 was variable ( range : 24 to 97 mm Hg ) . The correlation of pH with time from the beginning of resuscitation to arterial puncture was poor ( r=0.407, p 0.05 ) . There was no correlation between pH and BE ( r=0.267) or pH and pCO2, ( r=0.016) respectively . Prehospital capnometry had a poor correlation with arterial pCO2 in most emergeny patients . Only patients with respiratory disturbances of extrapulmonary origin showed a good correlation between end-tidal CO2 and the arterial pCO2. In severely ill patients the arterio-alveolar CO2-difference was unexpectedly high ( > 15 mm Hg ) . In four patients resuscitation was not sucessful until compensation of an unexpectedly severe acidosis based upon the findings from blood-gas analysis had been performed . Conclusions : Arterial blood gas analysis proved to be helpful in the optimal management of out of hospital cardiac arrest . The incidence of severe acidosis in patients undergoing cardiopulmonary resuscitation was 80% . The probability of developing acidosis was found to increase slightly depending on the time elapsed since the beginning of CPR . The application of a calculated buffering of acidosis with sodium bicarbonate showed a good outcome in selected cases . In emergency patients alternative methods fail to detect severe disturbances of the patients oxygen and/or carbon dioxide status and the acid-base balance . Management of prehospital cardiac arrest could be optimized by the routine use of blood gas analysis ."
],
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0,
2591
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[] |
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DerAnaesthesist.80470409.eng.abstr
|
DerAnaesthesist.80470409.eng.abstr
|
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],
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0,
456
]
]
}
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[] |
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DerAnaesthesist.80470442.eng.abstr
|
DerAnaesthesist.80470442.eng.abstr
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"Managed care , i.e. , the integration of health insurance and delivery of care under the direction of one organization , is gaining importance in the USA health market . The initial effects consisted of a decrease in insurance premiums , a very attractive feature for employers . Managed care promises to contain expenditures for health care . Given the shrinking public resources in Germany , managed care seems attractive for the German health system , too . In this review the development of managed care , the principal elements , forms of organisation and practical tools are outlined . The regulation of the delivery of care by means of controlling and financial incentives threatens the autonomy of physicians : the physician must act as a \" double agent \" , caring for the interest for the individual patient and being restricted by the contract with the managed care organisation . Cost containment by managed care was achieved by reducing the fees for physicians and hospitals ( and partly by restricting care for patients ) . Only a fraction of this cost reduction was handed over to the enrollee or employer , and most of the money was returned with profit to the shareholders of the managed care organisations . The preeminent role of primary care physicians as gatekeepers of the health network led to a reduced demand for specialist services in general and for university hospitals and anesthesiologists in particular . The paradigm of managed care , i.e. , to guide the patient and the care giver through the health care system in order to achieve cost-effective and high quality care , seems very attractive . The stress on cost minimization by any means in the daily practice of managed care makes it doubtful if managed care should be an option for the German health system , in particular because there are a number of restrictions on it in German law ."
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}
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DerAnaesthesist.80470460.eng.abstr
|
DerAnaesthesist.80470460.eng.abstr
|
[
{
"id": "DerAnaesthesist.80470460.eng.abstr-passage-0",
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"text": [
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],
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264,
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"id": "DerAnaesthesist.80470460.eng.abstr-s2-t5",
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147,
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{
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]
}
] |
[] |
[] |
[
{
"id": "DerAnaesthesist.80470460.eng.abstr-s1-r1-t1.2-t2.1",
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},
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},
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},
{
"id": "DerAnaesthesist.80470460.eng.abstr-s2-r2-t4.1-t6.1",
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},
{
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},
{
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},
{
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},
{
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},
{
"id": "DerAnaesthesist.80470460.eng.abstr-s2-r9-t4.1-t6.1",
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{
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"arg2_id": "DerAnaesthesist.80470460.eng.abstr-s2-t2",
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}
] |
DerAnaesthesist.80470475.eng.abstr
|
DerAnaesthesist.80470475.eng.abstr
|
[
{
"id": "DerAnaesthesist.80470475.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Children are very sensible to the occurrence of intraoperative hypothermia ( HT ) ( core temperature =36 . 0 C ) during general anaesthesia because their regulation capacity is less effective than in adults and due to a large skin-surface area compared with their body mass . We compared the efficacy of different heating devices to prevent HT in children during surgery ."
],
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[
0,
372
]
]
}
] |
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{
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],
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0,
8
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]
},
{
"id": "DerAnaesthesist.80470475.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"occurrence"
],
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34,
44
]
],
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{
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"db_id": "C0243132"
}
]
},
{
"id": "DerAnaesthesist.80470475.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"hypothermia"
],
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[
63,
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]
],
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"db_id": "C0020672"
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]
},
{
"id": "DerAnaesthesist.80470475.eng.abstr-s1-t4",
"type": "umlsterm",
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"temperature"
],
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89,
100
]
],
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"db_id": "C0039476"
},
{
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"db_id": "C0005903"
}
]
},
{
"id": "DerAnaesthesist.80470475.eng.abstr-s2-t1",
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"regulation"
],
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154,
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]
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}
]
},
{
"id": "DerAnaesthesist.80470475.eng.abstr-s2-t2",
"type": "umlsterm",
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"adults"
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200,
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{
"id": "DerAnaesthesist.80470475.eng.abstr-s2-t3",
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"general anaesthesia"
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120,
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"id": "DerAnaesthesist.80470475.eng.abstr-s3-t1",
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{
"id": "DerAnaesthesist.80470475.eng.abstr-s3-t2",
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}
]
},
{
"id": "DerAnaesthesist.80470475.eng.abstr-s3-t3",
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"children"
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347,
355
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}
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},
{
"id": "DerAnaesthesist.80470475.eng.abstr-s3-t4",
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"db_id": "C0038894"
},
{
"db_name": "UMLS",
"db_id": "C0038895"
}
]
}
] |
[] |
[] |
[
{
"id": "DerAnaesthesist.80470475.eng.abstr-s1-r1-t2.1-t4.2",
"type": "evaluation_of",
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},
{
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{
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},
{
"id": "DerAnaesthesist.80470475.eng.abstr-s3-r1-t1.1-t4.1",
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},
{
"id": "DerAnaesthesist.80470475.eng.abstr-s3-r2-t2.1-t4.1",
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},
{
"id": "DerAnaesthesist.80470475.eng.abstr-s3-r4-t2.2-t4.1",
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"arg2_id": "DerAnaesthesist.80470475.eng.abstr-s3-t4",
"normalized": []
}
] |
DerAnaesthesist.80470479.eng.abstr
|
DerAnaesthesist.80470479.eng.abstr
|
[
{
"id": "DerAnaesthesist.80470479.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Partial liquid ventilation ( PLV ) is a relatively new therapeutic approach to acute lung injury ( ALI ) and the acute respiratory distress syndrome ( ARDS ) . The idea of combining the intrapulmonary application of an oxygencarrying substance and positive pressure ventilation was introduced by Fuhrman in 1991 and originally called perfluorocarbonassociated gas exchange ( PAGE ) . Nowadays , the technique is mostly known as partial liquid ventilation ( PLV ) . The efficacy of PVL treatment has been demonstrated in numerous animal studies in different models of lung injury . The results of those studies led to multicenter phase I-II studies in patients of all age groups in the United States and Canada . Recently , the first randomized , controlled study in 90 adult patients suffering from ALI and ARDS was completed and first results have been published . Comparison of overall mortality and number of ventilator-free days ( VFD's ) in a 28-day period showed no differences between PLV and conventionally treated patients . A post-hoc stratification by age ( 55 years ) demonstrated a tendency to lower mortality ( PLV 25.6% ; CMV 36.8% ) and a significant increase of VFD ( PLV 8.95 days ; CMV 4.11 days ; p=0,03) in PLV when compared to conventionally treated patients . Perfluorocarbons ( PFCs ) are chemically stable and inert . They are mostly eliminated via exhalation ( > 99% ) . The unique physicochemical properties of PFCs permit access to atelectatic , non-ventilated lung areas , enhance gas exchange and decrease inflammation . The dense PFCs prevent the endexpiratory collapse of alveoli and reestablish functional residual capacity ( FRC ) . Comparable to positive endexpiratory pressure ( PEEP ) , these effects have been described as \" liquid or fluid PEEP \" . These properties offer a new approach to the underlying pathophysiology of ALI and ARDS . In addition , the combination with other therapeutic approaches to ALI and ARDS like high-frequency oscillations ( HFO ) , inhaled nitric oxide ( NO ) therapy , and surfactant replacement can be considered and is already the subject of recent publications . However , combination therapy is still experimental and further investigation is necessary to evaluate efficacy and potential risks . Many questions still exist which need to be answered by experimental as well as human pilot studies . Based on these studies , the results of ongoing human trials can be assessed properly and new multicenter trials can be planned effectively ."
],
"offsets": [
[
0,
2513
]
]
}
] |
[
{
"id": "DerAnaesthesist.80470479.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"ventilation"
],
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[
15,
26
]
],
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"db_id": "C0042491"
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"db_id": "C0035203"
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]
},
{
"id": "DerAnaesthesist.80470479.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"therapeutic"
],
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[
55,
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],
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"db_id": "C0039796"
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]
},
{
"id": "DerAnaesthesist.80470479.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"lung"
],
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[
85,
89
]
],
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"db_id": "C0024109"
}
]
},
{
"id": "DerAnaesthesist.80470479.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"injury"
],
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[
90,
96
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DerAnaesthesist.80470490.eng.abstr
|
DerAnaesthesist.80470490.eng.abstr
|
[
{
"id": "DerAnaesthesist.80470490.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Within the last few years the use of Point-of-Care Analyzers increased . These testing is primarily performed in the emergency room , intensive care units , and in the operating room using small portable analyzers . The fact of being transportable and working with rechargeable or changable batteries and disposable cartridges caused us to use blood gas analysis in the prehospital setting ."
],
"offsets": [
[
0,
391
]
]
}
] |
[
{
"id": "DerAnaesthesist.80470490.eng.abstr-s1-t1",
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"text": [
"use"
],
"offsets": [
[
30,
33
]
],
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DerAnaesthesist.80470496.eng.abstr
|
DerAnaesthesist.80470496.eng.abstr
|
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{
"id": "DerAnaesthesist.80470496.eng.abstr-passage-0",
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"In 1847 J.Y. Simpson in Scotland was the first to describe the administration of ether for analgesia in painful deliveries . Only a few days later E.C.J. von Siebold ( *1801 in Wuerzburg - \\dagger1861 in Goettingen ) performed the first systematic study on ether in obstetrics . Following a preceding evaluation of the action of ether on non-pregnant woman and on pregnant women not in active labour , he administered ether for analgesia during the second stage of labour in eight parturients . The first administration was on February 25th 1847. While he was satisfied with the good analgesia without sequelae of the new-born , he was discouraged by the termination of uterine contractions observed in all his patients . He concluded that ether was not a useful substance for analgesia during vaginal delivery , since it disturbed the natural course of labour . On the other hand , von Siebold was very pleased with the administration of ether for operative obstetric procedures such as forceps deliveries or placental retention ."
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[] |
[] |
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DerAnaesthesist.80470501.eng.abstr
|
DerAnaesthesist.80470501.eng.abstr
|
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"id": "DerAnaesthesist.80470501.eng.abstr-passage-0",
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"This review highlights the advantages of regional anaesthesia techniques , especially of epidural analgesia , for the management of postoperative and posttraumatic pain : excellent pain relief and a high degree of patient satisfaction , even compared to the gold standard of acute pain therapy , i.v. PCA with opioids . Further advantages of epidural analgesia ( EA ) are discussed , such as early recovery of gastrointestinal function , reduction of postoperative respiratory complications , lower incidence of myocardial ischema , better mobilisation , reduced risk of thromboembolism , lower incidence of chronic pain problems ( such as phantom limb pain ) etc. Nevertheless , many studies failed to show significant effects on outcome ( e.g. mortality ) . Weighing the risks , costs and benefits of EA , this technique is indicated in case of significant postoperative pain , especially in case of painful mobilisation , in patients with significant pulmonary risk factors ( ASA 3 or IV ) , in patients where an improved perfusion or gastrointestinal motility is deemed essential , and if chronic pain syndromes are common problems that should be prevented ( e.g. amputation ) . For the praxis of epidural analgesia it is emphasised to place the catheter in an appropriate segment to obtain sufficient analgesia without side effects . Organisational structures ( such as an acute pain service ) and appropriate monitoring allow to continue EA with local anaesthetics and/or opioids on surgical wards . Recommendations are given for the monitoring of EA on surgical wards . Clear cut agreements should define the role of anaesthesiologists , surgeons and nurses in the management of patients treated with postoperative EA on surgical wards ."
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[] |
[] |
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DerAnaesthesist.80470557.eng.abstr
|
DerAnaesthesist.80470557.eng.abstr
|
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107
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[] |
[] |
[] |
DerAnaesthesist.80470565.eng.abstr
|
DerAnaesthesist.80470565.eng.abstr
|
[
{
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0,
255
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[] |
[] |
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DerAnaesthesist.80470571.eng.abstr
|
DerAnaesthesist.80470571.eng.abstr
|
[
{
"id": "DerAnaesthesist.80470571.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Object of the study : The aim of the study was to assess , whether the pneumatic pressure of an antishock-trouser ( AST ) of 20-40 mm Hg induces a decreased oxygenation of the anterior tibial muscle and attenuates muscular response potential ( MRP ) of n . peronaeus profundus ?"
],
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0,
278
]
]
}
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26,
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"AST"
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116,
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]
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"oxygenation"
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157,
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]
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{
"id": "DerAnaesthesist.80470571.eng.abstr-s1-t5",
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"text": [
"anterior"
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176,
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"text": [
"muscle"
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192,
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{
"id": "DerAnaesthesist.80470571.eng.abstr-s1-t7",
"type": "umlsterm",
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"anterior tibial muscle"
],
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176,
198
]
],
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{
"db_name": "UMLS",
"db_id": "C0242690"
}
]
}
] |
[] |
[] |
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},
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}
] |
DerAnaesthesist.80470588.eng.abstr
|
DerAnaesthesist.80470588.eng.abstr
|
[
{
"id": "DerAnaesthesist.80470588.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Objective . In the German physician-based emergency medical system ( EMS ) psychiatric emergency situations ( PES ) rank on third place contradictory to it's importance during emergency physician training program . The aim of our study was to examine the relevance of PES and the stress which PES imposes upon EMS physicians . Further , the interest of training programs on that issue was determined . Knowledge about PES was investigated by a short test . Methods : 952 emergency physicians were sent a questionnaire about following : demographic data , frequency of PES , strain by PES , own knowledge , interest about training programs . Further five typical PES were presented for diagnostic and therapeutic judgement . Results : 222 responded ( 183 men/37 women/2 without gender data , average age : 40.1 +/- 6.7 , qualification as emergency physician : 9.6 +/- 5.1 years , most frequent subspeciality in-hospital physicians : anaesthesiology 67.5% , in-practice physicians : general medicine 72.1% ) . PES frequence was estimated at 9.4% , personal knowledge judged only by 13% as sufficient , 14.2 felt incapable by PES . 73% saw importance of training , especially expressed by the more experienced ( P 0.05 ) . Test presented 65% correct diagnoses , 33% correct therapy , 26% incorrect decision of hospital admission . Conclusion : PES are a frequent problem of pre-hospital patient care for emergency physicians . As personal knowledge was estimated to be insufficient , the interest for courses concerning PES issues is high ."
],
"offsets": [
[
0,
1537
]
]
}
] |
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"id": "DerAnaesthesist.80470588.eng.abstr-s1-t1",
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"Objective"
],
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[
0,
9
]
],
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},
{
"id": "DerAnaesthesist.80470588.eng.abstr-s2-t1",
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"text": [
"physician-based"
],
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[
26,
41
]
],
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{
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"db_id": "C0031831"
}
]
},
{
"id": "DerAnaesthesist.80470588.eng.abstr-s2-t2",
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"text": [
"emergency"
],
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42,
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]
],
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"emergency"
],
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87,
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"id": "DerAnaesthesist.80470588.eng.abstr-s2-t4",
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"PES"
],
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110,
113
]
],
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"db_id": "C0016504"
}
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{
"id": "DerAnaesthesist.80470588.eng.abstr-s2-t5",
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"text": [
"it's"
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153,
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]
],
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"db_id": "C0605770"
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"id": "DerAnaesthesist.80470588.eng.abstr-s2-t6",
"type": "umlsterm",
"text": [
"emergency"
],
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176,
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] |
DerAnaesthesist.80470595.eng.abstr
|
DerAnaesthesist.80470595.eng.abstr
|
[
{
"id": "DerAnaesthesist.80470595.eng.abstr-passage-0",
"type": "abstract",
"text": [
"We examined the efficacy of the vertical infraclavicular block for plexus brachialis anaesthesia using a nerve stimulator after introducing the method ( VIP1) and after three years of clinical experience ( VIP2). In two prospective studies we compared the results with each other as well as with the efficacy of the axillary block ( AX ) . At VIP1, we found a complete analgesia in 88% of the patients , whereas in 9% a supplementation was needed . In group AX the results were significantly worse ( complete : 70% , supplementation : 24% ; p 0.001 ) . No increase of the rate of efficacy could be found when having some clinical experience with the VIP ( VIP2: complete 87% , supplement : 11% ) . In general , the results of the VIP depended on the motoric answer to the nerve stimulation . There were no complications of the VIP such as nerve lesions or pneumothorax . The VIP using a nerve stimulator is a simple , reliable and uncomplicated method for plexus-brachialis-anaesthesia , which is easy to learn ."
],
"offsets": [
[
0,
1012
]
]
}
] |
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},
{
"id": "DerAnaesthesist.80470595.eng.abstr-s1-t3",
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"plexus brachialis"
],
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67,
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220,
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"analgesia"
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"id": "DerAnaesthesist.80470595.eng.abstr-s4-t1",
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"VIP"
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]
}
] |
[] |
[] |
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] |
DerAnaesthesist.80470600.eng.abstr
|
DerAnaesthesist.80470600.eng.abstr
|
[
{
"id": "DerAnaesthesist.80470600.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Hypothermia has a considerable protective effect during brain ischemia . On the other hand small increases of brain temperature have a remarkable effect on the exacerbation of neurological damage following an ischemic event . Hyperthermia of the brain tissue after severe head injury is described . The effect of acutely increased intracranial pressure on cerebrovenous blood temperature is not described yet . The aim of this study was to investigate the relationship between temperature in the cerebrovenous compartment ( Tcv ) and changes of the CPP in an animal model of raised intracranial pressure . Methods : A thermocouple was inserted in the sagittal sinus in 9 pigs under general anesthesia . By stepwise inflating a supracerebral and infratentorial placed balloon catheter intracranial pressure ( ICP ) was increased and CPP concomitantly decreased . The central body temperature was measured simultaneously in the abdominal aorta ( Ta ) with a second thermocouple . Results : In our model th Tcv was lower than Ta at the beginning of the ICP increase . The mean difference between Ta and Tcv , ( Ta-cv ) was 0,86 ° C ( +/- 0,44 ) prior to ICP increase and 1,19 ° C ( 0,58 ) at the maximum ICP increase . Thus , Tav increased during CPP reduction . This relation was represented by an adjusted R ( square ) of r2=0.89 ( p 0,001 ) . Conclusions : The CPP decrease , caused by an increasing ICP , results in changes of the cerebrovenous blood temperature . Interpreting the present results the experimental situation of a relative colder cerebral compartment in comparison to the central body temperature has to be considered . However , the results imply , that simultaneous temperature monitoring of the central body temperature and the cerebrovenpus blood temperature is an additional source of information about relative changes of the CBF ."
],
"offsets": [
[
0,
1854
]
]
}
] |
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"id": "DerAnaesthesist.80470600.eng.abstr-s14-r18-t1.1-t2.2",
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},
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"id": "DerAnaesthesist.80470600.eng.abstr-s15-r3-t5.1-t8.1",
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}
] |
DerAnaesthesist.80470629.eng.abstr
|
DerAnaesthesist.80470629.eng.abstr
|
[
{
"id": "DerAnaesthesist.80470629.eng.abstr-passage-0",
"type": "abstract",
"text": [
"In this article current indications and limitations of neuromuscular monitoring are reviewed . Attention is mainly focused on detection of residual curarisation . New insights in the pathophysiological consequences of residual neuromuscular blockade and the actual criteria of complete recovery are discussed . Surprisingly in this context , despite the benefit of neuromuscular monitoring , its utilisation in clinical practice is rather an exception than the routine . A lack of standardisation of neuromuscular monitoring is probably the major problem on the way to a widespread utilisation of the monitoring ."
],
"offsets": [
[
0,
613
]
]
}
] |
[
{
"id": "DerAnaesthesist.80470629.eng.abstr-s2-t1",
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"text": [
"Attention"
],
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[
95,
104
]
],
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{
"db_name": "UMLS",
"db_id": "C0004268"
}
]
},
{
"id": "DerAnaesthesist.80470629.eng.abstr-s3-t1",
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"criteria"
],
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[
265,
273
]
],
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{
"db_name": "UMLS",
"db_id": "C0243161"
}
]
},
{
"id": "DerAnaesthesist.80470629.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"neuromuscular blockade"
],
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[
227,
249
]
],
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{
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"db_id": "C0235062"
}
]
},
{
"id": "DerAnaesthesist.80470629.eng.abstr-s4-t1",
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"utilisation"
],
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{
"id": "DerAnaesthesist.80470629.eng.abstr-s5-t1",
"type": "umlsterm",
"text": [
"standardisation"
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481,
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"db_id": "C0038136"
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"id": "DerAnaesthesist.80470629.eng.abstr-s5-t2",
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"utilisation"
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[
582,
593
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0042153"
}
]
}
] |
[] |
[] |
[
{
"id": "DerAnaesthesist.80470629.eng.abstr-s5-r1-t1.1-t2.1",
"type": "measures",
"arg1_id": "DerAnaesthesist.80470629.eng.abstr-s5-t1",
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] |
DerAnaesthesist.80470638.eng.abstr
|
DerAnaesthesist.80470638.eng.abstr
|
[
{
"id": "DerAnaesthesist.80470638.eng.abstr-passage-0",
"type": "abstract",
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"This investigation was conducted as a national multicenter study to evaluate effectiveness and safety of prophylactic and therapeutic ondansetron for postoperative nausea and vomiting ( PONV ) in major gynaecological surgery ."
],
"offsets": [
[
0,
226
]
]
}
] |
[
{
"id": "DerAnaesthesist.80470638.eng.abstr-s1-t1",
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"text": [
"national"
],
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[
38,
46
]
],
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{
"db_name": "UMLS",
"db_id": "C0015737"
}
]
},
{
"id": "DerAnaesthesist.80470638.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"safety"
],
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95,
101
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],
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},
{
"id": "DerAnaesthesist.80470638.eng.abstr-s1-t3",
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"prophylactic"
],
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105,
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]
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122,
133
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]
},
{
"id": "DerAnaesthesist.80470638.eng.abstr-s1-t5",
"type": "umlsterm",
"text": [
"ondansetron"
],
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134,
145
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],
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"db_id": "C0061851"
}
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},
{
"id": "DerAnaesthesist.80470638.eng.abstr-s1-t6",
"type": "umlsterm",
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"postoperative"
],
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150,
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]
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}
]
},
{
"id": "DerAnaesthesist.80470638.eng.abstr-s1-t7",
"type": "umlsterm",
"text": [
"nausea"
],
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[
164,
170
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0027497"
}
]
},
{
"id": "DerAnaesthesist.80470638.eng.abstr-s1-t8",
"type": "umlsterm",
"text": [
"vomiting"
],
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[
175,
183
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"db_id": "C0042963"
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},
{
"id": "DerAnaesthesist.80470638.eng.abstr-s1-t9",
"type": "umlsterm",
"text": [
"PONV"
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186,
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},
{
"id": "DerAnaesthesist.80470638.eng.abstr-s1-t10",
"type": "umlsterm",
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"surgery"
],
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217,
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"db_name": "UMLS",
"db_id": "C0038894"
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"db_name": "UMLS",
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}
]
},
{
"id": "DerAnaesthesist.80470638.eng.abstr-s1-t11",
"type": "umlsterm",
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],
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47,
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"db_name": "UMLS",
"db_id": "C0282439"
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},
{
"id": "DerAnaesthesist.80470638.eng.abstr-s1-t12",
"type": "umlsterm",
"text": [
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150,
170
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],
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{
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"db_id": "C0520904"
}
]
},
{
"id": "DerAnaesthesist.80470638.eng.abstr-s1-t13",
"type": "umlsterm",
"text": [
"gynaecological surgery"
],
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[
202,
224
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0038902"
}
]
}
] |
[] |
[] |
[
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"type": "method_of",
"arg1_id": "DerAnaesthesist.80470638.eng.abstr-s1-t4",
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},
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"id": "DerAnaesthesist.80470638.eng.abstr-s1-r8-t12.1-t9.1",
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"arg2_id": "DerAnaesthesist.80470638.eng.abstr-s1-t9",
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{
"id": "DerAnaesthesist.80470638.eng.abstr-s1-r9-t12.1-t8.1",
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{
"id": "DerAnaesthesist.80470638.eng.abstr-s1-r10-t4.1-t5.1",
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{
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{
"id": "DerAnaesthesist.80470638.eng.abstr-s1-r13-t9.1-t8.1",
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{
"id": "DerAnaesthesist.80470638.eng.abstr-s1-r14-t9.1-t7.1",
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},
{
"id": "DerAnaesthesist.80470638.eng.abstr-s1-r15-t12.1-t4.1",
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{
"id": "DerAnaesthesist.80470638.eng.abstr-s1-r16-t1.1-t10.2",
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"id": "DerAnaesthesist.80470638.eng.abstr-s1-r17-t12.1-t3.1",
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},
{
"id": "DerAnaesthesist.80470638.eng.abstr-s1-r18-t9.1-t10.1",
"type": "issue_in",
"arg1_id": "DerAnaesthesist.80470638.eng.abstr-s1-t9",
"arg2_id": "DerAnaesthesist.80470638.eng.abstr-s1-t10",
"normalized": []
},
{
"id": "DerAnaesthesist.80470638.eng.abstr-s1-r19-t12.1-t10.1",
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},
{
"id": "DerAnaesthesist.80470638.eng.abstr-s1-r21-t9.1-t4.1",
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"arg2_id": "DerAnaesthesist.80470638.eng.abstr-s1-t4",
"normalized": []
},
{
"id": "DerAnaesthesist.80470638.eng.abstr-s1-r22-t3.1-t7.1",
"type": "treats",
"arg1_id": "DerAnaesthesist.80470638.eng.abstr-s1-t3",
"arg2_id": "DerAnaesthesist.80470638.eng.abstr-s1-t7",
"normalized": []
},
{
"id": "DerAnaesthesist.80470638.eng.abstr-s1-r23-t1.1-t9.1",
"type": "result_of",
"arg1_id": "DerAnaesthesist.80470638.eng.abstr-s1-t1",
"arg2_id": "DerAnaesthesist.80470638.eng.abstr-s1-t9",
"normalized": []
},
{
"id": "DerAnaesthesist.80470638.eng.abstr-s1-r24-t4.1-t7.1",
"type": "treats",
"arg1_id": "DerAnaesthesist.80470638.eng.abstr-s1-t4",
"arg2_id": "DerAnaesthesist.80470638.eng.abstr-s1-t7",
"normalized": []
},
{
"id": "DerAnaesthesist.80470638.eng.abstr-s1-r25-t5.1-t9.1",
"type": "affects",
"arg1_id": "DerAnaesthesist.80470638.eng.abstr-s1-t5",
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},
{
"id": "DerAnaesthesist.80470638.eng.abstr-s1-r26-t12.1-t8.1",
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"arg2_id": "DerAnaesthesist.80470638.eng.abstr-s1-t8",
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},
{
"id": "DerAnaesthesist.80470638.eng.abstr-s1-r27-t10.2-t9.1",
"type": "associated_with",
"arg1_id": "DerAnaesthesist.80470638.eng.abstr-s1-t10",
"arg2_id": "DerAnaesthesist.80470638.eng.abstr-s1-t9",
"normalized": []
},
{
"id": "DerAnaesthesist.80470638.eng.abstr-s1-r28-t5.1-t7.1",
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"arg1_id": "DerAnaesthesist.80470638.eng.abstr-s1-t5",
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},
{
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},
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] |
DerAnaesthesist.80470644.eng.abstr
|
DerAnaesthesist.80470644.eng.abstr
|
[
{
"id": "DerAnaesthesist.80470644.eng.abstr-passage-0",
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"text": [
"Objective : Autologous blood donation before elective surgery decreases the perioperative risk although donation itself can cause adverse effects . Are there specific donor characteristics , which influence the frequency and severity of adverse effects ?"
],
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[
0,
254
]
]
}
] |
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}
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{
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23,
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237,
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] |
[] |
[] |
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] |
DerAnaesthesist.80470663.eng.abstr
|
DerAnaesthesist.80470663.eng.abstr
|
[
{
"id": "DerAnaesthesist.80470663.eng.abstr-passage-0",
"type": "abstract",
"text": [
"In Germany a TCI-system for propofol ( Disoprifusor-TCI ) has been commercially available since spring 1997. We investigated the prediction error and precision of this TCI system as part of a multicentre study . Bias , precision , blood concentrations and dosage of propofol were compared with patients receiving propofol via a manually controlled infusion device ."
],
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[
0,
365
]
]
}
] |
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"id": "DerAnaesthesist.80470663.eng.abstr-s1-t1",
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10
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"id": "DerAnaesthesist.80470663.eng.abstr-s1-t2",
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},
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192,
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],
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}
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},
{
"id": "DerAnaesthesist.80470663.eng.abstr-s2-t1",
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"Bias"
],
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212,
216
]
],
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"db_id": "C0242568"
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]
},
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"id": "DerAnaesthesist.80470663.eng.abstr-s2-t2",
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[] |
[] |
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DerAnaesthesist.80470669.eng.abstr
|
DerAnaesthesist.80470669.eng.abstr
|
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[] |
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DerAnaesthesist.80470685.eng.abstr
|
DerAnaesthesist.80470685.eng.abstr
|
[
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"id": "DerAnaesthesist.80470685.eng.abstr-passage-0",
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"text": [
"As a consequence of the progress in ( perinatal ) medicine the number of pregnant women with severe cardiopulmonal risk , who need caesarean delivery , is rising . The anaesthetic care of these patients requires optimal preparation and - as a prerequisite - constant intraoperative vitalfunctions ( heartrate , bloodpressure , oxygensaturation ) . Typical risks like airway-problems , hypoxia , hyper- and hypotension and tachycardia must be strictly avoided . We report a case of successful caesarean delivery in a patient with severe coronary heart disease , using spinal catheter technique . Case report : The patient was a 36-year-old woman with a symptomatic coronary heart disease . Risk factors were hypercholesterinaemia , obesity ( 105 kg/168 cm ) , COPD consecutive to excessive nicotineabuse and hypertonia . Emergency admissions in the 12th and 14th gestation week led to the necessity of PTCA in the 15th and 19th gestation week in spite of pregnancy : coronary stenoses of 90% and 70% were dilated . Caesarean section was scheduled for 38 weeks ' gestation , however due to the high risk involved we decided to use a continuous spinal technique . There were no problems with introducing the catheter ( 28 gauge , L 3-4 interspace ) . Under careful titration a total of 2.2 ml plain bupivacaine 0.5% ( spinal catheter ) and 0.5 mg alfentanil ( intravenously ) were administered . This produced anaesthesia up to T 8 without any respiratory or cardiovascular embarrassment . A healthy male infant ( Apgar score 9/10/10 ) was delivered . Postoperative analgesia was provided by intrathecal injections of bupivacaine and intravenous injections of piritramide . There were no intraoperative or postoperative problems . Discussion : By means of continuous spinal anaesthesia for caesarean section it is possible to avoid typical complications of general anaesthesia ( hypoxia , airway management , aspiration , tachycardia ) , of single-shot spinal anaesthesia ( hypotension , low or high block ) and of epidural anaesthesia ( high dose of local anaesthetics , danger of accidental intrathecal or intravenous injection ) . The possibility of postoperative analgesia is advantageous . Technical difficulties , postspinal headache and the high costs of the sets may be disadvantageous . Conclusion : This case demonstrates , that the use of a continuous spinal catheter technique for caesarean section anaesthesia is an alternative method , which should be considered especially in high risk patients , when meticulous care for constant vital functions is requested urgently ."
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] |
DerAnaesthesist.80470707.eng.abstr
|
DerAnaesthesist.80470707.eng.abstr
|
[
{
"id": "DerAnaesthesist.80470707.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Injuries to the oro-dental tissue are still one of the most frequent mishaps during endotracheal intubation and general anaesthesia . However , damage to the soft and hard tissues in most cases involves oral structures already showing advanced pathogenic alterations . Injuries to the teeth are therefore rather more often due to the disease of the teeth than to mistakes during anaesthesia . The risk of injuries to the teeth can be ascertained by means of a presurgical inspection of the oral cavity and evaluation of the individual anatomical conditions in the head and neck region , which may well interfere with the endotracheal intubation . In contrast to anaesthetic pitfalls causing severe disturbance of general health , dental trauma can be treated with quite satisfying functional and aesthetic results . However , in order to maintain conditions for the complete restitution of injured teeth immediate dental therapy is recommended . In preterm infants which need mechanical ventilation during the postnatal period direct laryngoscopy as well as mechanical alterations caused by an oral tube can cause injuries to the tooth germs of the first and second dentition and deformation of the maxillary skeleton . In consequence the patient will need intensive therapy of the resulting disturbances for several years . This review gives information about the causes and types of injuries to the oral and maxillofacial region during general anaesthesia . In addition , the anatomical conditions and pathological changes associated with an increased risk for oro-dental injuries and the facilities for prevention are discussed . Finally , the main aspects of emergency treatment of injuries to the dental hard tissues are presented ."
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"id": "DerAnaesthesist.80470707.eng.abstr-s11-r13-t5.1-t3.1",
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] |
DerAnaesthesist.80470732.eng.abstr
|
DerAnaesthesist.80470732.eng.abstr
|
[
{
"id": "DerAnaesthesist.80470732.eng.abstr-passage-0",
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"text": [
"Despite numerous factors are thought to affect postoperative vomiting ( PV ) recent studies demonstrated that the risk of PV can be predicted by considering just the most important ones . Therefore , the aim of this study was to present the clinically most relevant factors , a risk score based upon those factors and its clinical applicability for other types of surgery ."
],
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[
0,
373
]
]
}
] |
[
{
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47,
60
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{
"id": "DerAnaesthesist.80470732.eng.abstr-s1-t2",
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61,
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"id": "DerAnaesthesist.80470732.eng.abstr-s1-t4",
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"postoperative vomiting"
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47,
69
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"id": "DerAnaesthesist.80470732.eng.abstr-s1-t5",
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"db_name": "UMLS",
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[] |
[] |
[
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"id": "DerAnaesthesist.80470732.eng.abstr-s1-r2-t2.1-t4.1",
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DerAnaesthesist.80470741.eng.abstr
|
DerAnaesthesist.80470741.eng.abstr
|
[
{
"id": "DerAnaesthesist.80470741.eng.abstr-passage-0",
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],
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[
0,
308
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}
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13,
22
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"id": "DerAnaesthesist.80470741.eng.abstr-s1-t2",
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102,
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197,
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"id": "DerAnaesthesist.80470741.eng.abstr-s2-t3",
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"id": "DerAnaesthesist.80470741.eng.abstr-s2-t4",
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271,
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"id": "DerAnaesthesist.80470741.eng.abstr-s2-t5",
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296,
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"id": "DerAnaesthesist.80470741.eng.abstr-s2-t6",
"type": "umlsterm",
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226,
244
]
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"normalized": [
{
"db_name": "UMLS",
"db_id": "C0002928"
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] |
[] |
[] |
[
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{
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] |
DerAnaesthesist.80470747.eng.abstr
|
DerAnaesthesist.80470747.eng.abstr
|
[
{
"id": "DerAnaesthesist.80470747.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Incomplete anaesthesia is a major clinical problem both in single spinal and in single epidural anaesthesia . The clinical efficacy of epidural anaesthesia with augmentation ( aEA ) and combined epidural and spinal anesthesia ( CSE ) for cesarean section was investigated in a prospective randomized study on 45 patients ."
],
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[
0,
322
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]
}
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[
{
"id": "DerAnaesthesist.80470747.eng.abstr-s1-t1",
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"id": "DerAnaesthesist.80470747.eng.abstr-s1-t3",
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87,
107
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"db_id": "C0002913"
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},
{
"id": "DerAnaesthesist.80470747.eng.abstr-s2-t1",
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215,
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135,
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{
"id": "DerAnaesthesist.80470747.eng.abstr-s2-t4",
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208,
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{
"id": "DerAnaesthesist.80470747.eng.abstr-s2-t5",
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238,
254
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],
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{
"db_name": "UMLS",
"db_id": "C0007876"
}
]
}
] |
[] |
[] |
[
{
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"id": "DerAnaesthesist.80470747.eng.abstr-s2-r2-t2.1-t5.1",
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"id": "DerAnaesthesist.80470747.eng.abstr-s2-r3-t2.1-t4.1",
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"id": "DerAnaesthesist.80470747.eng.abstr-s2-r4-t2.1-t3.1",
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"arg2_id": "DerAnaesthesist.80470747.eng.abstr-s2-t3",
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}
] |
DerAnaesthesist.80470757.eng.abstr
|
DerAnaesthesist.80470757.eng.abstr
|
[
{
"id": "DerAnaesthesist.80470757.eng.abstr-passage-0",
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"Obviously there is a world-wide trend towards regional analgesia for pain relief during delivery . Data on the current practice in Germany are lacking ."
],
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[
0,
152
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]
}
] |
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"trend"
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"id": "DerAnaesthesist.80470757.eng.abstr-s1-t2",
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"analgesia"
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55,
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{
"id": "DerAnaesthesist.80470757.eng.abstr-s1-t3",
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"id": "DerAnaesthesist.80470757.eng.abstr-s1-t4",
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[] |
[] |
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{
"id": "DerAnaesthesist.80470757.eng.abstr-s1-r1-t4.1-t3.1",
"type": "treats",
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},
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"id": "DerAnaesthesist.80470757.eng.abstr-s1-r2-t1.1-t3.1",
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"arg2_id": "DerAnaesthesist.80470757.eng.abstr-s1-t3",
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}
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DerAnaesthesist.80470765.eng.abstr
|
DerAnaesthesist.80470765.eng.abstr
|
[
{
"id": "DerAnaesthesist.80470765.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Acute pancreatitis is a multietiologic entity with rather diverse clinical courses . Whereas edematous pancreatitis has a mortality of less than 1% , nowadays ; still approximately 20% of all patients with the necrotizing form succumb to the disease . To further improve therapeutic results a standardized approach should be used . For effective treatment the differentiation between edematous and necrotizing pancreatitis is crucial . All patients with signs of pancreatic necroses during abdominal ultrasound and patients with organ insufficiencies should undergo a CT-scan to define exactly the nature and the extent of the disease . Primarily all patients are treated conservatively . Main indications for operative intervention are signs for infection of pancreatic necroses and an acute abdomen due to local complications of acute pancreatitis . In cases of biliary origin an elective cholecystectomy has to be performed during a free interval to prevent a recurrence ."
],
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[
0,
975
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]
}
] |
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{
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"id": "DerAnaesthesist.80470765.eng.abstr-s2-t2",
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"id": "DerAnaesthesist.80470765.eng.abstr-s3-t1",
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"id": "DerAnaesthesist.80470765.eng.abstr-s4-t3",
"type": "umlsterm",
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"necrotizing pancreatitis"
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"id": "DerAnaesthesist.80470765.eng.abstr-s5-t3",
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"signs"
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"id": "DerAnaesthesist.80470765.eng.abstr-s5-t5",
"type": "umlsterm",
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"id": "DerAnaesthesist.80470765.eng.abstr-s7-t1",
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{
"id": "DerAnaesthesist.80470765.eng.abstr-s7-t2",
"type": "umlsterm",
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"id": "DerAnaesthesist.80470765.eng.abstr-s7-t3",
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"pancreatic"
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"id": "DerAnaesthesist.80470765.eng.abstr-s7-t4",
"type": "umlsterm",
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"necroses"
],
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{
"id": "DerAnaesthesist.80470765.eng.abstr-s7-t5",
"type": "umlsterm",
"text": [
"abdomen"
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"id": "DerAnaesthesist.80470765.eng.abstr-s7-t6",
"type": "umlsterm",
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"id": "DerAnaesthesist.80470765.eng.abstr-s7-t7",
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"id": "DerAnaesthesist.80470765.eng.abstr-s7-t8",
"type": "umlsterm",
"text": [
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"id": "DerAnaesthesist.80470765.eng.abstr-s8-t1",
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"id": "DerAnaesthesist.80470765.eng.abstr-s8-t2",
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"id": "DerAnaesthesist.80470765.eng.abstr-s8-t3",
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"text": [
"recurrence"
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],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0034897"
}
]
}
] |
[] |
[] |
[
{
"id": "DerAnaesthesist.80470765.eng.abstr-s2-r1-t4.1-t3.1",
"type": "occurs_in",
"arg1_id": "DerAnaesthesist.80470765.eng.abstr-s7-t4",
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{
"id": "DerAnaesthesist.80470765.eng.abstr-s2-r2-t1.1-t3.1",
"type": "occurs_in",
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},
{
"id": "DerAnaesthesist.80470765.eng.abstr-s2-r3-t3.1-t4.1",
"type": "uses",
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},
{
"id": "DerAnaesthesist.80470765.eng.abstr-s2-r4-t4.1-t1.1",
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{
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{
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},
{
"id": "DerAnaesthesist.80470765.eng.abstr-s5-r3-t3.1-t1.1",
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{
"id": "DerAnaesthesist.80470765.eng.abstr-s5-r4-t3.1-t5.3",
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},
{
"id": "DerAnaesthesist.80470765.eng.abstr-s5-r5-t4.1-t1.1",
"type": "affects",
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{
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{
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{
"id": "DerAnaesthesist.80470765.eng.abstr-s5-r10-t8.1-t3.1",
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},
{
"id": "DerAnaesthesist.80470765.eng.abstr-s5-r11-t3.1-t5.3",
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{
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"arg2_id": "DerAnaesthesist.80470765.eng.abstr-s8-t1",
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},
{
"id": "DerAnaesthesist.80470765.eng.abstr-s5-r13-t3.1-t6.1",
"type": "affects",
"arg1_id": "DerAnaesthesist.80470765.eng.abstr-s8-t3",
"arg2_id": "DerAnaesthesist.80470765.eng.abstr-s7-t6",
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},
{
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DerAnaesthesist.80470833.eng.abstr
|
DerAnaesthesist.80470833.eng.abstr
|
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],
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[
0,
443
]
]
}
] |
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] |
[] |
[] |
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DerAnaesthesist.80470844.eng.abstr
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DerAnaesthesist.80470844.eng.abstr
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"id": "DerAnaesthesist.80470844.eng.abstr-passage-0",
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"Determination of Functional Residual Capacity ( FRC ) can be performed through washout methods , indicator gas dilution or bodyplethysmography . Some of these techniques have been adapted for use in intensive care patients whilst being mechanically ventilated . However , most measurement setups are bulky , cumbersome to use and their running costs are high . Hence FRC measurement has not become a routine method in intensive care although it offers considerable advantages in the management of ventilated patients such as the determination of \" best PEEP \" , the detection of progressive alveolar collapse in the course of acute lung injury and during weaning from mechanical ventilation . Up to now most efforts to improve and simplify FRC measurement were made at the expense of accuracy . An ideal method ought to be accurate , easy to handle and cost-effective . It should supply not only FRC data but also information about intrapulmonary gas distribution and dead space . These demands can be met using modern data acquisition software . The pros and cons of all methods available for FRC measurement are discussed in view of their suitability for intensive care patients . A conventional nitrogen washout using emission spectroscopy for measurement of nitrogen concentration gives satisfying exact values for the determination of the parameters mentioned above . The measurement error can be lowered under 5% by special corrections for flow and nitrogen signal ( delay and rise times , changes of gas viscosity ) . For flow measurement a normal pneumotachograph can be used . Using a laptop computer for data acquisition the bed-side monitor fulfills most of the demands in intensive care . It is then also possible to measure indices of intrapulmonary gas distribution such as Alveolar Mixing Efficiency and Lung Clearance Index ."
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DerAnaesthesist.80470903.eng.abstr
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DerAnaesthesist.80470903.eng.abstr
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"Echocardiography is a noninvasive method for cardiac evaluation . A review of the current literature shows that the routine use of echocardiography for assessing perioperative cardiac risk in patients undergoing noncardiac surgery can not be supported . Only patients with suspected relevant heart valve diseases , acute heart failure , cardiomyopathy or condition after heart or heart-lung transplantation may benefit from preoperative echocardiography . In patients with suspected or proven coronary artery disease stress echocardiography offers the most relevant additional information for the anaesthesiologist . However , because of the high financial and personal implications it should be reserved to those patients who are not able to perform a normal stress test . Besides in patients in whom transthoracic echocardiography doesn ' t offer sufficient information or is not possible transesophageal echocardiography plays only a minor role in preoperative cardiac evaluation ."
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[] |
[] |
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] |
DerAnaesthesist.80470912.eng.abstr
|
DerAnaesthesist.80470912.eng.abstr
|
[
{
"id": "DerAnaesthesist.80470912.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Objectives : To investigate the agreement ( and its potential dependency on extravascular lung water ) between transpulmonary ( TPID ) and standard pulmonary artery ( PAID ) thermodilution cardiac output measurements ."
],
"offsets": [
[
0,
218
]
]
}
] |
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10
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90,
94
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100
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"id": "DerAnaesthesist.80470912.eng.abstr-s1-t9",
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148,
164
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{
"id": "DerAnaesthesist.80470912.eng.abstr-s1-t10",
"type": "umlsterm",
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76,
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DerAnaesthesist.80470918.eng.abstr
|
DerAnaesthesist.80470918.eng.abstr
|
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{
"id": "DerAnaesthesist.80470918.eng.abstr-passage-0",
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"text": [
"Propofol is known to possess direct antiemetic effects . Its use for induction and maintenance of anaesthesia has been shown to be associated with a lower incidence of postoperative nausea and vomiting ( PONV ) when compared to any other anaesthetic drug or technique . However , its mechanism of action in this context is still not well understood . In this article , the best ways to take advantage of propofol's antiemetic properties are emphasized . The possible effects of propofol on the cerebral cortex , its interactions with the dopaminergic and the serotoninergic systems are evaluated by the known clinical and basic science results . Finally , the advantages and disadvantages of using propofol to decrease the incidence of PONV in clinical practice are discussed ."
],
"offsets": [
[
0,
777
]
]
}
] |
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{
"id": "DerAnaesthesist.80470918.eng.abstr-s1-t2",
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"text": [
"direct"
],
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29,
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]
],
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{
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}
]
},
{
"id": "DerAnaesthesist.80470918.eng.abstr-s1-t3",
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"antiemetic"
],
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36,
46
]
],
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{
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},
{
"id": "DerAnaesthesist.80470918.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"use"
],
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61,
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]
],
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},
{
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"maintenance"
],
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"text": [
"incidence"
],
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],
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},
{
"id": "DerAnaesthesist.80470918.eng.abstr-s2-t4",
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"text": [
"postoperative"
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{
"id": "DerAnaesthesist.80470918.eng.abstr-s2-t5",
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},
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"id": "DerAnaesthesist.80470918.eng.abstr-s2-t6",
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"vomiting"
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193,
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{
"id": "DerAnaesthesist.80470918.eng.abstr-s2-t7",
"type": "umlsterm",
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"PONV"
],
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204,
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]
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},
{
"id": "DerAnaesthesist.80470918.eng.abstr-s2-t8",
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],
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"id": "DerAnaesthesist.80470918.eng.abstr-s2-t9",
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"drug"
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"id": "DerAnaesthesist.80470918.eng.abstr-s2-t11",
"type": "umlsterm",
"text": [
"postoperative nausea"
],
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DerAnaesthesist.80470925.eng.abstr
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DerAnaesthesist.80470925.eng.abstr
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"id": "DerAnaesthesist.80470925.eng.abstr-passage-0",
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"The official German guidelines for prevention of nosocomial pneumonia were published by the Bundesgesundheitsamt , now called Robert-Koch-Institut , twelve years ago . The recently published official \" guidelines for prevention of nosocomial pneumonia \" of the Centers for Disease Control and Prevention ( CDC ) are categorized according to scientific evidence . The American guidelines are very detailed and differ in some aspects from the official German guidelines . The purpose of the present paper is to inform the German anaesthesiologist about the official CDC guidelines and to provide a renewed background for the prevention of nosocomial pneumonia ."
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[] |
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DerAnaesthesist.80470936.eng.abstr
|
DerAnaesthesist.80470936.eng.abstr
|
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"id": "DerAnaesthesist.80470936.eng.abstr-passage-0",
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0,
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[] |
[] |
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DerAnaesthesist.80470957.eng.abstr
|
DerAnaesthesist.80470957.eng.abstr
|
[
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"id": "DerAnaesthesist.80470957.eng.abstr-passage-0",
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"text": [
"Evidence Based ( Emergency ) Medicine ( EB ( E ) M is a term referring to the application into daily clinical practice of only those methods , procedures , medications etc. which are based on scientific evidence . Where diagnostic and therapeutic principles have not been validated on a prospective , controlled randomised basis , this should be tried out at a later time , if at all possible . This concept may allow to bridge the gap between research and clinical practice , and represents the major goal of EB ( E ) M. Protagonists of EBEM are at times confronted with criticism that EBEM does not constitute the only but one out of several possible approaches to quality controlled medical care . The fact that more than 50% of all emergency procedures are not evidence based give rise to the question as to whether the performance of randomised controlled studies is ethically justifiable , if control groups are included whose treatment leaves out generally recommended and recognised ( though not evidence based ) therapeutic and/or diagnostic principles . The following examples may enumerate some of the procedures , methods or medications , respectively , without proven scientific evidence : ..."
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[] |
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DerAnaesthesist.80470968.eng.abstr
|
DerAnaesthesist.80470968.eng.abstr
|
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[] |
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] |
DerAnaesthesist.8047s007.eng.abstr
|
DerAnaesthesist.8047s007.eng.abstr
|
[
{
"id": "DerAnaesthesist.8047s007.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Sevoflurane , like all currently used volatile anaesthetics , is degraded by carbon dioxide absorbents . The most significant degradant is a haloalkene known trivially as \" compound A \" . Compound A is nephrotoxic in rats and , at higher doses , in nonhuman primates , causing proximal tubular necrosis . There has been much interest in the potential for compound A toxicity in humans . Inhaled compound A concentrations are greatest at low flow rates , high sevoflurane concentrations , warmer absorbent , barium hydroxide vs soda lime , and drier absorbent . Typical inspired compound A concentrations during low-flow and closed-circuit sevoflurane anaesthesia in humans are 8-24 and 20-32 ppm with soda lime and barium hydroxide lime , respectively . Renal effects of compound A production during sevoflurane anesthesia have been examined in surgical patients and volunteers , using standard ( creatinine clearance , serum BUN and creatinine ) and experimental ( urine excretion of protein , glucose , NAG , GST , AAP ) markers of renal function . Investigations to date in surgical patients show similar renal effects of low-flow sevoflurane , low-flow isoflurane or high-flow sevoflurane . There have been no case reports of compound A-associated renal injury in humans . In volunteers , one study found changes in experimental but not conventional renal markers , while other investigations show no significant changes in either standard or experimental markers . The mechanism of compound A nephrotoxicity in rats appears to involve metabolism to glutathione and cysteine conjugates , and their subsequent renal uptake and metabolism by pathways that are different in rats and humans ."
],
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[
0,
1692
]
]
}
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},
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},
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},
{
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}
] |
DerAnaesthesist.8047s011.eng.abstr
|
DerAnaesthesist.8047s011.eng.abstr
|
[
{
"id": "DerAnaesthesist.8047s011.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The cardiovascular effects of sevoflurane are similar to those of isoflurane with some minor exceptions . In contrast to isoflurane and particularly to desflurane , sevoflurane has not been associated with increases in heart rate in healthy volunteers and in patients . The coronary vasodilatory potency of sevoflurane appears to be lower than that of isoflurane and it has not been associated with a reduction of blood flow to collateral myocardium in dogs with steal-prone anatomy . In several multi-center studies of patients with coronary artery disease or at high risk for coronary artery disease receiving either sevoflurane or isoflurane for either cardiac or non-cardiac surgery , the incidence of myocardial ischemia and infarction did not differ between treatment groups . In both human and animal models , sevoflurane preserves cerebral blood flow and reduces cerebral metabolic rate , much like isoflurane ."
],
"offsets": [
[
0,
919
]
]
}
] |
[
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121,
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] |
[] |
[] |
[
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},
{
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{
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DerAnaesthesist.8047s019.eng.abstr
|
DerAnaesthesist.8047s019.eng.abstr
|
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"In common with other halogenated volatile anaesthetics , sevoflurane causes a dose-related cardiovascular depression and therefore the affection of blood flow of different organ systems is suggested . So far known , sevoflurane is not different compared to isoflurane in affecting liver and splanchnic blood flow . Concluded from former published studies there was no case of hepatic toxicity of sevoflurane been published so that this substance can be used in patients with reduced hepatic function . The primary organic metabolite of sevoflurane is hexafluorisopropanol ( HFIP ) , which is readily and rapidly conjugated with glucuronic acid . No reactive intermediates are formed and HFIP appears to be an unlikely compound to form liver protein adducts . For this reasons sevoflurane \" hepatitis \" is not expected . Like most other inhalation agents sevoflurane increase the neuromuscular blockade after treatment with muscle relaxants in anaesthesia . The MAC values of Sevoflurane where reduced after the application of nitrous oxide , benzodiazepines and opiates . From human studies we know that chronic drug therapy with isoniazid induces the metabolism of sevoflurane , enflurane and isoflurane , markedly increasing peak plasma fluoride concentrations . However , barbiturates as well as phenytoin do not influence the metabolism of sevoflurane because these agents do not induce the major hepatic defluorinating enzyme cytochrome P450 2E1. Obesity , untreated diabetes mellitus and alcohol abuse increase the hepatic content and activity of cytochrome P450 2E1 and therefore enhanced anaesthetic defluorination is to be suspected . Until now , there are no studies about sevoflurane anaesthesia in patients after liver transplantation but the extremely low hepatotoxic potential as compared to isoflurane provides no argument to avoid this substance for anesthesia in liver transplanted patients ."
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] |
[] |
[] |
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] |
DerAnaesthesist.8047s024.eng.abstr
|
DerAnaesthesist.8047s024.eng.abstr
|
[
{
"id": "DerAnaesthesist.8047s024.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The new inhalational anesthetic sevoflurane is biotransformed by approximately 5% . Serum fluoride concentrations resulting from transformation mainly depend on rate of hepatic defluorination , total amount of anesthetic given and the solubility of the volatile anesthetic , as expressed by its blood gas partition coefficient . Enflurane is metabolized by 5-11% . However subsequent peak fluoride levels are lower than after sevoflurane which is a consequence of its lower rate of hepatic defluorination . To date numerous studies have examined the nephrotoxic potential of the sevoflurane degradation product fluoride . However , fluoride-related toxicity was not observed , neither in clinical or in animal studies , nor after prolonged administration or in patients with preexisting renal disease . New insights into intrarenal metabolisation of volatile anesthetics may well explain absence of nephrotoxicity after sevoflurane . The threshold of fluoride nephrotoxicity of 50 µmol/l, which has been empirically found after methoxyflurane , and which is still listed in many medical textbooks , can not be assumed a marker of nephrotoxicity after isoflurane , enflurane or sevoflurane . Therefore also , the elevated serum fluoride concentrations , as regularly obtained after anesthesia with sevoflurane are devoid of clinical significance . In addition , exposure to sevoflurane or its metabolites is not associated with hepatic toxicity ."
],
"offsets": [
[
0,
1445
]
]
}
] |
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"normalized": []
},
{
"id": "DerAnaesthesist.8047s024.eng.abstr-s9-r3-t4.1-t1.1",
"type": "interacts_with",
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},
{
"id": "DerAnaesthesist.8047s024.eng.abstr-s9-r4-t2.1-t4.1",
"type": "uses",
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},
{
"id": "DerAnaesthesist.8047s024.eng.abstr-s9-r5-t4.1-t2.1",
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"normalized": []
},
{
"id": "DerAnaesthesist.8047s024.eng.abstr-s10-r1-t1.1-t2.1",
"type": "treats",
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"normalized": []
},
{
"id": "DerAnaesthesist.8047s024.eng.abstr-s10-r2-t1.1-t2.1",
"type": "causes",
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"arg2_id": "DerAnaesthesist.8047s024.eng.abstr-s10-t2",
"normalized": []
}
] |
DerAnaesthesist.8047s033.eng.abstr
|
DerAnaesthesist.8047s033.eng.abstr
|
[
{
"id": "DerAnaesthesist.8047s033.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Sevoflurane degrades in CO2 absorbents to produce compound A , which may have hepatotoxic potential in humans . Several recent studies in human volunteers have been performed to evaluate this potential . Three studies have evaluated sevoflurane administered to volunteers using a 3% concentration for 8 h duration at approximately 2 L/min flow rate . The initial investigation found high excretion of protein , glucose and renal tubular enzymes in the urine of the volunteers receiving sevoflurane . Subsequent investigations using identical protocols found more minor or absent changes in excretion of these markers . One additional investigation in volunteers studied 3% sevoflurane anesthesia for 4 h duration using a low-flow ( 1 L/min ) technique . No significant excretion of protein , glucose or renal enzymes was observed . Application of these results to clinical practice must be interpreted in light of the experimental nature of the anesthetic administration . Although some controversy remains , these data , combined with results of recent studies in surgical patients , suggest that renal function following modest duration low-flow sevoflurane anesthesia is similar to that following isoflurane anesthesia ."
],
"offsets": [
[
0,
1223
]
]
}
] |
[
{
"id": "DerAnaesthesist.8047s033.eng.abstr-s1-t1",
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"Sevoflurane"
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0,
11
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]
},
{
"id": "DerAnaesthesist.8047s033.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"CO2"
],
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[
24,
27
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}
]
},
{
"id": "DerAnaesthesist.8047s033.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"humans"
],
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103,
109
]
],
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{
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]
},
{
"id": "DerAnaesthesist.8047s033.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"compound A"
],
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50,
60
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{
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}
]
},
{
"id": "DerAnaesthesist.8047s033.eng.abstr-s2-t1",
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"human"
],
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[
138,
143
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}
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},
{
"id": "DerAnaesthesist.8047s033.eng.abstr-s2-t2",
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"text": [
"volunteers"
],
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144,
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},
{
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"human volunteers"
],
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138,
154
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]
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{
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"type": "umlsterm",
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"sevoflurane"
],
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233,
244
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{
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}
]
},
{
"id": "DerAnaesthesist.8047s033.eng.abstr-s3-t2",
"type": "umlsterm",
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"volunteers"
],
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261,
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],
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}
]
},
{
"id": "DerAnaesthesist.8047s033.eng.abstr-s3-t3",
"type": "umlsterm",
"text": [
"concentration"
],
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283,
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]
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{
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]
},
{
"id": "DerAnaesthesist.8047s033.eng.abstr-s4-t1",
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"protein"
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401,
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]
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]
},
{
"id": "DerAnaesthesist.8047s033.eng.abstr-s4-t2",
"type": "umlsterm",
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"glucose"
],
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411,
418
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],
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}
]
},
{
"id": "DerAnaesthesist.8047s033.eng.abstr-s4-t3",
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"enzymes"
],
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437,
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}
]
},
{
"id": "DerAnaesthesist.8047s033.eng.abstr-s4-t4",
"type": "umlsterm",
"text": [
"urine"
],
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452,
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{
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]
},
{
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{
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"id": "DerAnaesthesist.8047s033.eng.abstr-s5-t1",
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"minor"
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{
"id": "DerAnaesthesist.8047s033.eng.abstr-s5-t2",
"type": "umlsterm",
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"markers"
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{
"id": "DerAnaesthesist.8047s033.eng.abstr-s6-t3",
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"anesthesia"
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{
"id": "DerAnaesthesist.8047s033.eng.abstr-s6-t4",
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"technique"
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{
"id": "DerAnaesthesist.8047s033.eng.abstr-s7-t1",
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"protein"
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{
"id": "DerAnaesthesist.8047s033.eng.abstr-s7-t2",
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"id": "DerAnaesthesist.8047s033.eng.abstr-s9-t1",
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"surgical"
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"id": "DerAnaesthesist.8047s033.eng.abstr-s9-t4",
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1148,
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{
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"isoflurane"
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1200,
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{
"id": "DerAnaesthesist.8047s033.eng.abstr-s9-t7",
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"anesthesia"
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],
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{
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}
]
}
] |
[] |
[] |
[
{
"id": "DerAnaesthesist.8047s033.eng.abstr-s1-r1-t4.2-t4.1",
"type": "interacts_with",
"arg1_id": "DerAnaesthesist.8047s033.eng.abstr-s4-t4",
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{
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},
{
"id": "DerAnaesthesist.8047s033.eng.abstr-s1-r5-t4.1-t4.2",
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{
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{
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},
{
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},
{
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},
{
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},
{
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},
{
"id": "DerAnaesthesist.8047s033.eng.abstr-s4-r4-t3.1-t3.2",
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{
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},
{
"id": "DerAnaesthesist.8047s033.eng.abstr-s4-r6-t1.1-t6.1",
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},
{
"id": "DerAnaesthesist.8047s033.eng.abstr-s4-r7-t6.1-t1.1",
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},
{
"id": "DerAnaesthesist.8047s033.eng.abstr-s4-r8-t3.1-t1.1",
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"arg2_id": "DerAnaesthesist.8047s033.eng.abstr-s9-t1",
"normalized": []
},
{
"id": "DerAnaesthesist.8047s033.eng.abstr-s4-r9-t4.2-t3.2",
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"arg2_id": "DerAnaesthesist.8047s033.eng.abstr-s7-t3",
"normalized": []
},
{
"id": "DerAnaesthesist.8047s033.eng.abstr-s4-r10-t1.1-t3.1",
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{
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] |
DerAnaesthesist.8047s037.eng.abstr
|
DerAnaesthesist.8047s037.eng.abstr
|
[
{
"id": "DerAnaesthesist.8047s037.eng.abstr-passage-0",
"type": "abstract",
"text": [
"During sevoflurane anaesthesia cerebral blood flow is preserved or slightly decreased . Cerebral oxygen consumption is reduced to 50% under 1 MAC sevoflurane . Autoregulation of cerebral blood flow and responsiveness of cerebral blood flow to changes in Pa CO2 are widely preserved . Sevoflurane produces a dose dependent increase in intracranial pressure and a decrease in cerebrovascular resistance that can not be observed under hypocapnic conditions . Central stimulus processing , the electroencephalogram and sensory evoked potentials are suppressed under sevoflurane in a dose dependent fashion . The electrophysiological data indicate that intraoperative awareness phenomena should be suppressed with sevoflurane 1.5-2.0 vol . % . Recovery of cognitive and psychomotor functions seems to be faster and more complete after sevoflurane than after isoflurane anaesthesia . In inducing seizure like EEG or muscle activity , sevoflurane seems to be comparable with isoflurane . There is no limitation of sevoflurane use in patients with concomitant psychiatric or neurological diseases , and sevoflurane may be valuable addition in neurosurgery or carotid surgery ."
],
"offsets": [
[
0,
1168
]
]
}
] |
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DerAnaesthesist.8047s043.eng.abstr
|
DerAnaesthesist.8047s043.eng.abstr
|
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"id": "DerAnaesthesist.8047s043.eng.abstr-passage-0",
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"Inhalational anaesthesia is the most common anaesthesia technique in paediatric anaesthesia worldwide . Up to now the standard anaesthetic used is halothane . Because halothane is tolerated in the upper airways without side effects it is well suited for the inhalational induction of anaesthesia . However , halothane exerts side effects on the hepatic and the cardiovascular system . This review focuses on the replacement of halothane by sevoflurane in paediatric anaesthesia . Apart from its favorable pharmacological properties sevoflurane is also superior because of economical considerations . The following conclusions are drawn : ( 1 ) Halothane and sevoflurane do not cause irritations of the airways and are thus suitable for an inhalational induction . Sevoflurane should be administered in oxygen/nitrous oxide during induction of anaesthesia to reduce excitation . ( 2 ) The MAC values of sevoflurane are age dependent . In contrast to adult patients the MAC values of sevoflurane are only decreased by 20 to 25% in paediatric patients . The end-tidal concentration of sevoflurane necessary for intubation or insertion of a laryngeal mask is 2 to 4 Vol . % . ( 3 ) The blood/gas partition coefficient of sevoflurane is low , resulting in shorter induction times with sevoflurane compared to halothane . The so called priming technique with 8 Vol . % of sevoflurane results in shorter induction times . Consequently , times to recovery and psycho-motor functions are favourable for sevoflurane compared to halothane in paediatric patients . However , shorter recovery times lead to earlier perception of postoperative pain , requiring adequate pain management . ( 4 ) The hemodynamic stability after administration of sevoflurane is favourable to that after halothane in paediatric patients , leading to significantly less bradycardia . ( 5 ) In paediatric patients no negative effects on kidney function have been observed after administration of sevoflurane . There is no scientific basis for organotoxic effects , thus sevoflurane is suitable for low-flow and minimal-flow anaesthesia . ( 6 ) The duration of the action of muscle relaxants is increased to a greater extent in presence of sevoflurane compared to halothane . Consequently , the total dose of muscle relaxants can be reduced using sevoflurane . ( 7 ) Similar to the established inhalational anaesthetics sevoflurane triggers malignant hyperthermia ( MH ) and must not be used in patients in which MH is suspected or in which a predisposition for MH is known ."
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DerAnaesthesist.8047s049.eng.abstr
|
DerAnaesthesist.8047s049.eng.abstr
|
[
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"id": "DerAnaesthesist.8047s049.eng.abstr-passage-0",
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"Sevoflurane is a viable alternative to propofol and desflurane for both induction and maintenance of general anaesthesia in the ambulatory setting . As a result of sevoflurane's lack of respiratory irritant properties , it provides for a smooth induction and prompt emergence from outpatient anaesthesia . In addition , the relatively low incidence of postoperative nausea and vomiting facilitates \" fast-tracking \" after ambulatory surgery . Although no single anaesthetic agent is ideal , when sevoflurane is combined with other adjunctive drugs it can produce excellent surgical conditions for a wide variety of ambulatory surgical and diagnostic procedures ."
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662
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]
}
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[] |
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"id": "DerAnaesthesist.8047s049.eng.abstr-s3-r10-t5.2-t3.1",
"type": "associated_with",
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"arg2_id": "DerAnaesthesist.8047s049.eng.abstr-s4-t3",
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},
{
"id": "DerAnaesthesist.8047s049.eng.abstr-s3-r11-t6.1-t4.1",
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},
{
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},
{
"id": "DerAnaesthesist.8047s049.eng.abstr-s3-r13-t1.1-t5.1",
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},
{
"id": "DerAnaesthesist.8047s049.eng.abstr-s3-r14-t5.2-t4.1",
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},
{
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},
{
"id": "DerAnaesthesist.8047s049.eng.abstr-s4-r1-t3.1-t1.1",
"type": "interacts_with",
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},
{
"id": "DerAnaesthesist.8047s049.eng.abstr-s4-r2-t1.1-t8.2",
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}
] |
DerAnaesthesist.8047s052.eng.abstr
|
DerAnaesthesist.8047s052.eng.abstr
|
[
{
"id": "DerAnaesthesist.8047s052.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The low blood/gas solubility , the rapid uptake and nonpungent odor permits mask induction with sevoflurane in adults . Depending on the induction techniques ( tidal breathing , deep breaths or single-breath induction ) , the use of nitrous oxide and the concentration of inspired sevoflurane anesthesia can rapidly be induced within 41-178 s. Adverse effects like coughing , breath-holding or increased secretions occur with a low incidence of 2%-20% . Some 88 to 100% of the volunteers or patients would accept a mask induction again . Clinical experience shows that sevoflurane is well indicated for mask induction in adults ."
],
"offsets": [
[
0,
629
]
]
}
] |
[
{
"id": "DerAnaesthesist.8047s052.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"solubility"
],
"offsets": [
[
18,
28
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0037628"
}
]
},
{
"id": "DerAnaesthesist.8047s052.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"odor"
],
"offsets": [
[
63,
67
]
],
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{
"db_name": "UMLS",
"db_id": "C0028884"
}
]
},
{
"id": "DerAnaesthesist.8047s052.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"mask"
],
"offsets": [
[
76,
80
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0024861"
}
]
},
{
"id": "DerAnaesthesist.8047s052.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"sevoflurane"
],
"offsets": [
[
96,
107
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0074414"
}
]
},
{
"id": "DerAnaesthesist.8047s052.eng.abstr-s1-t5",
"type": "umlsterm",
"text": [
"adults"
],
"offsets": [
[
111,
117
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0001675"
}
]
},
{
"id": "DerAnaesthesist.8047s052.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"techniques"
],
"offsets": [
[
147,
157
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0025664"
}
]
},
{
"id": "DerAnaesthesist.8047s052.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"breathing"
],
"offsets": [
[
166,
175
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0035203"
},
{
"db_name": "UMLS",
"db_id": "C0004048"
}
]
},
{
"id": "DerAnaesthesist.8047s052.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"single-breath"
],
"offsets": [
[
194,
207
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0087136"
}
]
},
{
"id": "DerAnaesthesist.8047s052.eng.abstr-s2-t4",
"type": "umlsterm",
"text": [
"use"
],
"offsets": [
[
226,
229
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0042153"
}
]
},
{
"id": "DerAnaesthesist.8047s052.eng.abstr-s2-t5",
"type": "umlsterm",
"text": [
"oxide"
],
"offsets": [
[
241,
246
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0030015"
}
]
},
{
"id": "DerAnaesthesist.8047s052.eng.abstr-s2-t6",
"type": "umlsterm",
"text": [
"concentration"
],
"offsets": [
[
255,
268
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0086045"
}
]
},
{
"id": "DerAnaesthesist.8047s052.eng.abstr-s2-t7",
"type": "umlsterm",
"text": [
"sevoflurane"
],
"offsets": [
[
281,
292
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0074414"
}
]
},
{
"id": "DerAnaesthesist.8047s052.eng.abstr-s2-t8",
"type": "umlsterm",
"text": [
"anesthesia"
],
"offsets": [
[
293,
303
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0002903"
}
]
},
{
"id": "DerAnaesthesist.8047s052.eng.abstr-s2-t9",
"type": "umlsterm",
"text": [
"secretions"
],
"offsets": [
[
404,
414
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0036537"
},
{
"db_name": "UMLS",
"db_id": "C0036536"
}
]
},
{
"id": "DerAnaesthesist.8047s052.eng.abstr-s2-t10",
"type": "umlsterm",
"text": [
"incidence"
],
"offsets": [
[
432,
441
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0220856"
},
{
"db_name": "UMLS",
"db_id": "C0021149"
}
]
},
{
"id": "DerAnaesthesist.8047s052.eng.abstr-s2-t11",
"type": "umlsterm",
"text": [
"nitrous oxide"
],
"offsets": [
[
233,
246
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0028215"
}
]
},
{
"id": "DerAnaesthesist.8047s052.eng.abstr-s2-t12",
"type": "umlsterm",
"text": [
"Adverse effects"
],
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[
344,
359
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0001688"
}
]
},
{
"id": "DerAnaesthesist.8047s052.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"volunteers"
],
"offsets": [
[
477,
487
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0042960"
}
]
},
{
"id": "DerAnaesthesist.8047s052.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"patients"
],
"offsets": [
[
491,
499
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0030705"
}
]
},
{
"id": "DerAnaesthesist.8047s052.eng.abstr-s3-t3",
"type": "umlsterm",
"text": [
"mask"
],
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[
515,
519
]
],
"normalized": [
{
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}
]
},
{
"id": "DerAnaesthesist.8047s052.eng.abstr-s4-t1",
"type": "umlsterm",
"text": [
"sevoflurane"
],
"offsets": [
[
569,
580
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0074414"
}
]
},
{
"id": "DerAnaesthesist.8047s052.eng.abstr-s4-t2",
"type": "umlsterm",
"text": [
"mask"
],
"offsets": [
[
603,
607
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0024861"
}
]
},
{
"id": "DerAnaesthesist.8047s052.eng.abstr-s4-t3",
"type": "umlsterm",
"text": [
"adults"
],
"offsets": [
[
621,
627
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0001675"
}
]
}
] |
[] |
[] |
[
{
"id": "DerAnaesthesist.8047s052.eng.abstr-s1-r1-t4.1-t2.1",
"type": "affects",
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},
{
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},
{
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{
"id": "DerAnaesthesist.8047s052.eng.abstr-s2-r4-t11.1-t3.1",
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{
"id": "DerAnaesthesist.8047s052.eng.abstr-s2-r5-t3.1-t1.1",
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},
{
"id": "DerAnaesthesist.8047s052.eng.abstr-s2-r6-t7.1-t3.1",
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},
{
"id": "DerAnaesthesist.8047s052.eng.abstr-s2-r7-t2.2-t9.1",
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},
{
"id": "DerAnaesthesist.8047s052.eng.abstr-s2-r8-t1.1-t6.1",
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},
{
"id": "DerAnaesthesist.8047s052.eng.abstr-s2-r9-t6.1-t1.1",
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{
"id": "DerAnaesthesist.8047s052.eng.abstr-s2-r10-t9.2-t12.1",
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{
"id": "DerAnaesthesist.8047s052.eng.abstr-s2-r12-t6.1-t2.2",
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},
{
"id": "DerAnaesthesist.8047s052.eng.abstr-s2-r15-t6.1-t12.1",
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},
{
"id": "DerAnaesthesist.8047s052.eng.abstr-s2-r16-t3.1-t1.1",
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},
{
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},
{
"id": "DerAnaesthesist.8047s052.eng.abstr-s2-r18-t7.1-t6.1",
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},
{
"id": "DerAnaesthesist.8047s052.eng.abstr-s2-r19-t3.1-t9.2",
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},
{
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"normalized": []
},
{
"id": "DerAnaesthesist.8047s052.eng.abstr-s2-r21-t11.1-t2.2",
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"arg2_id": "DerAnaesthesist.8047s052.eng.abstr-s2-t2",
"normalized": []
},
{
"id": "DerAnaesthesist.8047s052.eng.abstr-s2-r22-t11.1-t12.1",
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},
{
"id": "DerAnaesthesist.8047s052.eng.abstr-s2-r23-t11.1-t6.1",
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},
{
"id": "DerAnaesthesist.8047s052.eng.abstr-s2-r24-t6.1-t1.1",
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},
{
"id": "DerAnaesthesist.8047s052.eng.abstr-s2-r25-t3.1-t12.1",
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},
{
"id": "DerAnaesthesist.8047s052.eng.abstr-s2-r26-t7.1-t1.1",
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},
{
"id": "DerAnaesthesist.8047s052.eng.abstr-s2-r27-t4.1-t2.2",
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},
{
"id": "DerAnaesthesist.8047s052.eng.abstr-s2-r28-t6.1-t7.1",
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{
"id": "DerAnaesthesist.8047s052.eng.abstr-s2-r29-t6.1-t9.2",
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{
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DerAnaesthesist.8047s070.eng.abstr
|
DerAnaesthesist.8047s070.eng.abstr
|
[
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"id": "DerAnaesthesist.8047s070.eng.abstr-passage-0",
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"Due to its low solubility and the high maximum concentration delivered by the vaporizer sevoflurane is especially suitable for the performance of low flow anaesthetic techniques . High flow phases for wash-in or wash-out of anaesthetic gases can be kept short , the difference between the volatile's concentration in the fresh gas and within the breathing system is comparatively small , and the time constants are short even during low flow anaesthesia . The monitoring , required to sufficiently ensure the safety of the patients , corresponds to the current obliging technical safety standards . As compound A may accumulate in the breathing system , sevoflurane should not be administered with fresh gas flows lower than 1.0 l/min , until the scientific discussion on nephrotoxicity of this substance in humans is solved . Low flow anaesthesia guarantees a sufficient and continuous wash-out of trace gases . Thoroughly the use of sevoflurane with dry soda lime must be avoided , as this volatile in an extreme exothermic reaction is absorbed nearly totally and degraded to a considerable degree by dry carbon dioxide absorbent . The gaseous degradation products are pungent and possibly may be harmful to the patients . Only by low flow anaesthesia the use of sevoflurane will gain an economically and ecologically acceptable range of efficiency ."
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}
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] |
[] |
[] |
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] |
DerAnaesthesist.8047s077.eng.abstr
|
DerAnaesthesist.8047s077.eng.abstr
|
[
{
"id": "DerAnaesthesist.8047s077.eng.abstr-passage-0",
"type": "abstract",
"text": [
"There are a number of assays available to study genetic toxicity of inhalation anaesthetics . Those discussed in this review are the Ames Salmonella mutagenesis test and assays for structural chromosome aberrations , micronuclei ( MN ) and sister chromatid exchanges ( SCEs ) . None of these assays showed abnormalities induced by volatile inhalation anaesthetics . Only Compound A induced a slight increase in the number of SCEs . However , the implications of this in vitro study are unclear . Results of studies focussing on the effects of long-term occupational exposure to inhalation anaesthetics are controversial . Neither harmfulness nor safety of chronic exposure to low concentrations of inhalation anaesthetics have been proven . Although there is no clear evidence of harmfulness , there is general agreement that occupational exposure should be minimized for precautionary reasons . This particularly applies to N2O. Therefore , occupational exposure standards have been established in many countries , though not yet for sevoflurane and desflurane . In Germany , occupational exposure can be kept below the threshold values , when working in operation theatres with a standard air conditioning system , a high-flow scavenging system , low leakage anaesthesia machines and preventative maintenance of equipment . Under these conditions occupational exposure is low even when using laryngeal mask airways and uncuffed tracheal tubes . Sevoflurane is a halocarbon , but is only partially halogenated and the only halogen it contains is fluorine . Sevoflurane , therefore , appears to have an insignificant effect on ozone depletion and its contribution to the greenhouse effect is negligible ."
],
"offsets": [
[
0,
1704
]
]
}
] |
[
{
"id": "DerAnaesthesist.8047s077.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"toxicity"
],
"offsets": [
[
56,
64
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0600688"
},
{
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},
{
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},
{
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},
{
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},
{
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{
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},
{
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},
{
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},
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},
{
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},
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},
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},
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},
{
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},
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"normalized": []
}
] |
DerAnaesthesist.8047s087.eng.abstr
|
DerAnaesthesist.8047s087.eng.abstr
|
[
{
"id": "DerAnaesthesist.8047s087.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The total costs for a department of anaesthesia amount to a fraction of the total hospital budget that is proportional to the overall number of hospital departments ; this means anaesthetic departments are in general not cost drivers ."
],
"offsets": [
[
0,
235
]
]
}
] |
[
{
"id": "DerAnaesthesist.8047s087.eng.abstr-s1-t1",
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"text": [
"costs"
],
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[
10,
15
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0010186"
},
{
"db_name": "UMLS",
"db_id": "C0010181"
},
{
"db_name": "UMLS",
"db_id": "C0220812"
}
]
},
{
"id": "DerAnaesthesist.8047s087.eng.abstr-s1-t2",
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"hospital"
],
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[
82,
90
]
],
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{
"db_name": "UMLS",
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}
]
},
{
"id": "DerAnaesthesist.8047s087.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"budget"
],
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[
91,
97
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0006347"
}
]
},
{
"id": "DerAnaesthesist.8047s087.eng.abstr-s1-t4",
"type": "umlsterm",
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"overall"
],
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[
126,
133
]
],
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{
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"db_id": "C0282416"
}
]
},
{
"id": "DerAnaesthesist.8047s087.eng.abstr-s1-t5",
"type": "umlsterm",
"text": [
"hospital"
],
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[
144,
152
]
],
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{
"db_name": "UMLS",
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}
]
},
{
"id": "DerAnaesthesist.8047s087.eng.abstr-s1-t6",
"type": "umlsterm",
"text": [
"anaesthetic"
],
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[
178,
189
]
],
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{
"db_name": "UMLS",
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}
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},
{
"id": "DerAnaesthesist.8047s087.eng.abstr-s1-t7",
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"cost"
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221,
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]
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}
]
},
{
"id": "DerAnaesthesist.8047s087.eng.abstr-s1-t8",
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"hospital departments"
],
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144,
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]
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{
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}
]
},
{
"id": "DerAnaesthesist.8047s087.eng.abstr-s1-t9",
"type": "umlsterm",
"text": [
"anaesthetic departments"
],
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[
178,
201
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0002907"
}
]
}
] |
[] |
[] |
[] |
DerAnaesthesist.90480003.eng.abstr
|
DerAnaesthesist.90480003.eng.abstr
|
[
{
"id": "DerAnaesthesist.90480003.eng.abstr-passage-0",
"type": "abstract",
"text": [
"After successful centralization of laboratory analyses since more than 30 years , advances in biosensors , microprocessors , measurement of undiluted whole blood and miniaturization of laboratory analyzers are leading nowadays more and more to a re-decentralization in the laboratory medicine . Point-of-care-testing ( POCT ) , which is defined as any laboratory test performed outside central or decentralized laboratories , is becoming more and more popular . The theoretical advantages of POCT are faster turn-around-times ( TAT ) , more rapid medical decisions , avoidance of sample identification and sample transport problems and the need of only small specimen volumes . These advantages are frequently mentioned , but are not associated with a clear clinical benefit . The disadvantages of POCT such as incorrect handling and/or maintenance of the analyzers by non-trained clinical staff , inadequate or even absent calibrations and/or quality controls , lack of cost-effectiveness because of an increased number of analyzers and more expensive reagents , insufficient documentation and difficult comparability of the obtained POCT-results with routine laboratory results , are strongly evident . According to the authors ' opinion the decision for the establishing of POCT has only to be made in a close co-operation between physicians and laboratorians in order to vouch for necessity and high quality of the analyses . Taking the local situation into consideration ( 24-h-central laboratory , etc. ) the spectrum of parameters measured by means of POCT should be rigorously restricted to the vital functions . Such analytes should be : hemoglobin or hematocrit , activated whole blood clotting time , blood gases , sodium , potassium , ionized calcium , glucose , creatinine , ammonia and lactate ."
],
"offsets": [
[
0,
1809
]
]
}
] |
[
{
"id": "DerAnaesthesist.90480003.eng.abstr-s1-t1",
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"laboratory"
],
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35,
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]
],
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}
]
},
{
"id": "DerAnaesthesist.90480003.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"analyses"
],
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[
46,
54
]
],
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"db_id": "C0002778"
}
]
},
{
"id": "DerAnaesthesist.90480003.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"biosensors"
],
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[
94,
104
]
],
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{
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"db_id": "C0600364"
}
]
},
{
"id": "DerAnaesthesist.90480003.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"microprocessors"
],
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[
107,
122
]
],
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"db_id": "C0026012"
}
]
},
{
"id": "DerAnaesthesist.90480003.eng.abstr-s1-t5",
"type": "umlsterm",
"text": [
"measurement"
],
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[
125,
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]
],
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{
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"db_id": "C0242485"
}
]
},
{
"id": "DerAnaesthesist.90480003.eng.abstr-s1-t6",
"type": "umlsterm",
"text": [
"blood"
],
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[
156,
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]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0005767"
},
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"db_name": "UMLS",
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},
{
"db_name": "UMLS",
"db_id": "C0005835"
}
]
},
{
"id": "DerAnaesthesist.90480003.eng.abstr-s1-t7",
"type": "umlsterm",
"text": [
"miniaturization"
],
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[
166,
181
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0026164"
}
]
},
{
"id": "DerAnaesthesist.90480003.eng.abstr-s1-t8",
"type": "umlsterm",
"text": [
"laboratory"
],
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[
185,
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]
],
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{
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}
]
},
{
"id": "DerAnaesthesist.90480003.eng.abstr-s1-t9",
"type": "umlsterm",
"text": [
"re-decentralization"
],
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[
246,
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]
],
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"db_id": "C0011101"
}
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},
{
"id": "DerAnaesthesist.90480003.eng.abstr-s1-t10",
"type": "umlsterm",
"text": [
"laboratory"
],
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},
{
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},
{
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},
{
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{
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}
] |
DerAnaesthesist.90480009.eng.abstr
|
DerAnaesthesist.90480009.eng.abstr
|
[
{
"id": "DerAnaesthesist.90480009.eng.abstr-passage-0",
"type": "abstract",
"text": [
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],
"offsets": [
[
0,
320
]
]
}
] |
[
{
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],
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}
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"surgery"
],
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[
35,
42
]
],
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]
},
{
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],
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119,
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]
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{
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"blood"
],
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215,
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]
],
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},
{
"db_name": "UMLS",
"db_id": "C0005835"
}
]
},
{
"id": "DerAnaesthesist.90480009.eng.abstr-s1-t5",
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"text": [
"vascular surgery"
],
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26,
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]
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}
]
},
{
"id": "DerAnaesthesist.90480009.eng.abstr-s2-t1",
"type": "umlsterm",
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"balance"
],
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276,
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]
],
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}
]
},
{
"id": "DerAnaesthesist.90480009.eng.abstr-s2-t2",
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"text": [
"fluid balance"
],
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[
270,
283
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0016284"
}
]
}
] |
[] |
[] |
[
{
"id": "DerAnaesthesist.90480009.eng.abstr-s1-r1-t4.2-t2.1",
"type": "issue_in",
"arg1_id": "DerAnaesthesist.90480009.eng.abstr-s1-t4",
"arg2_id": "DerAnaesthesist.90480009.eng.abstr-s2-t2",
"normalized": []
},
{
"id": "DerAnaesthesist.90480009.eng.abstr-s1-r2-t5.1-t2.2",
"type": "affects",
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},
{
"id": "DerAnaesthesist.90480009.eng.abstr-s1-r3-t1.1-t2.1",
"type": "issue_in",
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"arg2_id": "DerAnaesthesist.90480009.eng.abstr-s2-t2",
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},
{
"id": "DerAnaesthesist.90480009.eng.abstr-s1-r4-t4.1-t2.2",
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},
{
"id": "DerAnaesthesist.90480009.eng.abstr-s1-r5-t5.1-t1.1",
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},
{
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},
{
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"type": "performs",
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},
{
"id": "DerAnaesthesist.90480009.eng.abstr-s1-r10-t4.1-t5.1",
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},
{
"id": "DerAnaesthesist.90480009.eng.abstr-s1-r11-t5.1-t2.1",
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{
"id": "DerAnaesthesist.90480009.eng.abstr-s1-r12-t2.2-t4.2",
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{
"id": "DerAnaesthesist.90480009.eng.abstr-s1-r13-t4.1-t2.1",
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"arg2_id": "DerAnaesthesist.90480009.eng.abstr-s2-t2",
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}
] |
DerAnaesthesist.90480019.eng.abstr
|
DerAnaesthesist.90480019.eng.abstr
|
[
{
"id": "DerAnaesthesist.90480019.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Background : Droperidol even in low doses such as 0,5 mg to 1,25 mg can increase postoperative anxiety and state of tension . The aim of this study was to determine whether these side effects occur frequently following low-dose droperidol and to see whether these are dose related ."
],
"offsets": [
[
0,
282
]
]
}
] |
[
{
"id": "DerAnaesthesist.90480019.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"Droperidol"
],
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[
13,
23
]
],
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"db_id": "C0013136"
}
]
},
{
"id": "DerAnaesthesist.90480019.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"postoperative"
],
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[
81,
94
]
],
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{
"db_name": "UMLS",
"db_id": "C0032790"
}
]
},
{
"id": "DerAnaesthesist.90480019.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"anxiety"
],
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[
95,
102
]
],
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{
"db_name": "UMLS",
"db_id": "C0003467"
}
]
},
{
"id": "DerAnaesthesist.90480019.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"aim"
],
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[
130,
133
]
],
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{
"db_name": "UMLS",
"db_id": "C0108800"
}
]
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{
"id": "DerAnaesthesist.90480019.eng.abstr-s2-t2",
"type": "umlsterm",
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"droperidol"
],
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228,
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]
],
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"db_id": "C0013136"
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{
"id": "DerAnaesthesist.90480019.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"side effects"
],
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[
179,
191
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0001688"
}
]
}
] |
[] |
[] |
[
{
"id": "DerAnaesthesist.90480019.eng.abstr-s1-r1-t2.1-t3.1",
"type": "result_of",
"arg1_id": "DerAnaesthesist.90480019.eng.abstr-s2-t2",
"arg2_id": "DerAnaesthesist.90480019.eng.abstr-s2-t3",
"normalized": []
},
{
"id": "DerAnaesthesist.90480019.eng.abstr-s1-r2-t3.1-t2.1",
"type": "occurs_in",
"arg1_id": "DerAnaesthesist.90480019.eng.abstr-s2-t3",
"arg2_id": "DerAnaesthesist.90480019.eng.abstr-s2-t2",
"normalized": []
},
{
"id": "DerAnaesthesist.90480019.eng.abstr-s1-r3-t1.1-t3.1",
"type": "treats",
"arg1_id": "DerAnaesthesist.90480019.eng.abstr-s2-t1",
"arg2_id": "DerAnaesthesist.90480019.eng.abstr-s2-t3",
"normalized": []
},
{
"id": "DerAnaesthesist.90480019.eng.abstr-s1-r4-t1.1-t3.1",
"type": "affects",
"arg1_id": "DerAnaesthesist.90480019.eng.abstr-s2-t1",
"arg2_id": "DerAnaesthesist.90480019.eng.abstr-s2-t3",
"normalized": []
},
{
"id": "DerAnaesthesist.90480019.eng.abstr-s2-r1-t3.1-t1.1",
"type": "produces",
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},
{
"id": "DerAnaesthesist.90480019.eng.abstr-s2-r2-t1.1-t3.1",
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"normalized": []
},
{
"id": "DerAnaesthesist.90480019.eng.abstr-s2-r3-t1.1-t3.1",
"type": "indicates",
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"normalized": []
},
{
"id": "DerAnaesthesist.90480019.eng.abstr-s2-r4-t1.1-t3.1",
"type": "causes",
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},
{
"id": "DerAnaesthesist.90480019.eng.abstr-s2-r5-t1.1-t3.1",
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"arg2_id": "DerAnaesthesist.90480019.eng.abstr-s2-t3",
"normalized": []
},
{
"id": "DerAnaesthesist.90480019.eng.abstr-s2-r6-t1.1-t3.1",
"type": "complicates",
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"arg2_id": "DerAnaesthesist.90480019.eng.abstr-s2-t3",
"normalized": []
},
{
"id": "DerAnaesthesist.90480019.eng.abstr-s2-r7-t1.1-t3.1",
"type": "treats",
"arg1_id": "DerAnaesthesist.90480019.eng.abstr-s2-t1",
"arg2_id": "DerAnaesthesist.90480019.eng.abstr-s2-t3",
"normalized": []
}
] |
DerAnaesthesist.90480063.eng.abstr
|
DerAnaesthesist.90480063.eng.abstr
|
[
{
"id": "DerAnaesthesist.90480063.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Object of this review is to present the physiological principles , diagnostic techniques and therapeutic options that are related to modifications of oxygen delivery in sepsis . Despite intense research activities in this area , many topics regarding oxygen transport and oxygen consumption in sepsis are still not clear . For example , the often discussed shift of the critical value of oxygen delivery to higher values in sepsis has not been proven , yet . Beside an impaired regional perfusion also disturbances in the cellular oxygen utilization may be responsible for organ failure in sepsis . Until now , it was not shown , whether the increase of oxygen delivery to supranormal levels reduces mortality in septic patients . It is also unknown , which catecholamine and which infusion solution is suitable for the treatment of septic patients . In future further research is necessary to solve the problems associated with sepsis therapy ."
],
"offsets": [
[
0,
945
]
]
}
] |
[
{
"id": "DerAnaesthesist.90480063.eng.abstr-s1-t1",
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],
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21
]
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"db_name": "UMLS",
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}
]
},
{
"id": "DerAnaesthesist.90480063.eng.abstr-s1-t2",
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"text": [
"diagnostic"
],
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[
67,
77
]
],
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{
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"db_id": "C0348026"
}
]
},
{
"id": "DerAnaesthesist.90480063.eng.abstr-s1-t3",
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"text": [
"techniques"
],
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[
78,
88
]
],
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{
"db_name": "UMLS",
"db_id": "C0025664"
}
]
},
{
"id": "DerAnaesthesist.90480063.eng.abstr-s1-t4",
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] |
DerAnaesthesist.90480080.eng.abstr
|
DerAnaesthesist.90480080.eng.abstr
|
[
{
"id": "DerAnaesthesist.90480080.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Background : Postoperative nausea and vomiting ( PONV ) is still one of the major problems in strabismus surgery , especially in children . In recent years many studies have been published , suggesting that choosing propofol as the anaesthetic agent may help to reduce the high incidence of PONV in children undergoing strabismus surgery . Experience with remifentanil in children is still very limited and little is known , whether propofol in combination with this new short acting opioid is also superior regarding PONV in squint surgery compared to sevoflurane/N2O. Additionally , little is known , whether the type of operation or the muscle which is operated on has any influence with respect to PONV ."
],
"offsets": [
[
0,
708
]
]
}
] |
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13,
26
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],
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],
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{
"id": "DerAnaesthesist.90480080.eng.abstr-s1-t4",
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"PONV"
],
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],
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"id": "DerAnaesthesist.90480080.eng.abstr-s1-t7",
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33
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{
"id": "DerAnaesthesist.90480080.eng.abstr-s2-t1",
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"propofol"
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216,
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{
"id": "DerAnaesthesist.90480080.eng.abstr-s2-t2",
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{
"id": "DerAnaesthesist.90480080.eng.abstr-s2-t4",
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DerAnaesthesist.90480108.eng.abstr
|
DerAnaesthesist.90480108.eng.abstr
|
[
{
"id": "DerAnaesthesist.90480108.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The volume of preoperative screening investigations for outpatient anaesthesia ranges from few , selectively ordered investigations to extensive routine diagnostic procedures . It seem appropriate to reevaluate benefit and efficacy of routine preoperative assessment programs . The purpose of preoperative diagnostic is to assess the risk of anaesthesia and surgery for the patient . As shown by a number of studies , preoperative screening investigations seldom disclose new pathological findings of clinical relevance . Abnormal laboratory results in otherwise healthy patients rarely alter the anaesthetic management of the patient and are not related to perioperative complications . Extensive use of costly diagnostic procedures considerably increases health care budgets . A more selective approach to order preoperative investigations promises considerable savings . To achieve costeffective evalulation an efficient organisation of properative assessment must be established to avoid costly delay and on-day-of-surgery-cancellations . There is no medicolegal obligation to perform routine diagnostic testing . The anaesthetist must be sufficiently informed in time to assess the perioperative risk of the patient and to alter anaesthetic management as necessary . According to the presented studies a clinical history and a thorough physical examination represent an effective method of screening for the presence of disease . Careful medical history evaluation and physical examination can avoid extensive investigations in apparently healthy individuals and the latter should only be ordered if indicated ."
],
"offsets": [
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0,
1616
]
]
}
] |
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[] |
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DerAnaesthesist.90480157.eng.abstr
|
DerAnaesthesist.90480157.eng.abstr
|
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310
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}
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[
152,
180
]
],
"normalized": [
{
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"db_id": "C0027866"
}
]
},
{
"id": "DerAnaesthesist.90480157.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"muscle"
],
"offsets": [
[
193,
199
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0026845"
}
]
},
{
"id": "DerAnaesthesist.90480157.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"mivacurium"
],
"offsets": [
[
218,
228
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0066621"
}
]
},
{
"id": "DerAnaesthesist.90480157.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"fast"
],
"offsets": [
[
239,
243
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0015663"
}
]
}
] |
[] |
[] |
[
{
"id": "DerAnaesthesist.90480157.eng.abstr-s1-r1-t4.1-t5.1",
"type": "uses",
"arg1_id": "DerAnaesthesist.90480157.eng.abstr-s1-t4",
"arg2_id": "DerAnaesthesist.90480157.eng.abstr-s1-t5",
"normalized": []
},
{
"id": "DerAnaesthesist.90480157.eng.abstr-s1-r2-t4.1-t3.1",
"type": "measures",
"arg1_id": "DerAnaesthesist.90480157.eng.abstr-s1-t4",
"arg2_id": "DerAnaesthesist.90480157.eng.abstr-s2-t3",
"normalized": []
},
{
"id": "DerAnaesthesist.90480157.eng.abstr-s1-r3-t4.1-t3.1",
"type": "uses",
"arg1_id": "DerAnaesthesist.90480157.eng.abstr-s1-t4",
"arg2_id": "DerAnaesthesist.90480157.eng.abstr-s2-t3",
"normalized": []
},
{
"id": "DerAnaesthesist.90480157.eng.abstr-s1-r4-t5.1-t1.1",
"type": "disrupts",
"arg1_id": "DerAnaesthesist.90480157.eng.abstr-s1-t5",
"arg2_id": "DerAnaesthesist.90480157.eng.abstr-s2-t1",
"normalized": []
},
{
"id": "DerAnaesthesist.90480157.eng.abstr-s1-r5-t3.1-t1.1",
"type": "disrupts",
"arg1_id": "DerAnaesthesist.90480157.eng.abstr-s2-t3",
"arg2_id": "DerAnaesthesist.90480157.eng.abstr-s2-t1",
"normalized": []
},
{
"id": "DerAnaesthesist.90480157.eng.abstr-s1-r6-t1.1-t4.1",
"type": "location_of",
"arg1_id": "DerAnaesthesist.90480157.eng.abstr-s2-t1",
"arg2_id": "DerAnaesthesist.90480157.eng.abstr-s1-t4",
"normalized": []
},
{
"id": "DerAnaesthesist.90480157.eng.abstr-s1-r7-t4.1-t5.1",
"type": "measures",
"arg1_id": "DerAnaesthesist.90480157.eng.abstr-s1-t4",
"arg2_id": "DerAnaesthesist.90480157.eng.abstr-s1-t5",
"normalized": []
},
{
"id": "DerAnaesthesist.90480157.eng.abstr-s2-r1-t2.1-t1.1",
"type": "disrupts",
"arg1_id": "DerAnaesthesist.90480157.eng.abstr-s2-t2",
"arg2_id": "DerAnaesthesist.90480157.eng.abstr-s2-t1",
"normalized": []
},
{
"id": "DerAnaesthesist.90480157.eng.abstr-s2-r2-t1.1-t2.1",
"type": "location_of",
"arg1_id": "DerAnaesthesist.90480157.eng.abstr-s2-t1",
"arg2_id": "DerAnaesthesist.90480157.eng.abstr-s2-t2",
"normalized": []
},
{
"id": "DerAnaesthesist.90480157.eng.abstr-s2-r3-t1.1-t2.1",
"type": "produces",
"arg1_id": "DerAnaesthesist.90480157.eng.abstr-s2-t1",
"arg2_id": "DerAnaesthesist.90480157.eng.abstr-s2-t2",
"normalized": []
}
] |
DerAnaesthesist.90480164.eng.abstr
|
DerAnaesthesist.90480164.eng.abstr
|
[
{
"id": "DerAnaesthesist.90480164.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Background : Rocuronium is a non-depolarising neuromuscular blocking agent structurally related to vecuronium . The compound has a rapid onset and an intermediate duration of action . The rapid onset is of importance in patients at risk for pulmonary aspiration , for elective induction of anaesthesia slower onset properties generally are accepted . In this context , we asked whether the induction dose of rocuronium may be reduced to doses smaller than 2xED95 in situations in which slower onset properties may be acceptable ."
],
"offsets": [
[
0,
529
]
]
}
] |
[
{
"id": "DerAnaesthesist.90480164.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"Rocuronium"
],
"offsets": [
[
13,
23
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0209337"
}
]
},
{
"id": "DerAnaesthesist.90480164.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"vecuronium"
],
"offsets": [
[
99,
109
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0242531"
}
]
},
{
"id": "DerAnaesthesist.90480164.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"neuromuscular blocking"
],
"offsets": [
[
46,
68
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0235062"
}
]
},
{
"id": "DerAnaesthesist.90480164.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"neuromuscular blocking agent"
],
"offsets": [
[
46,
74
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0027866"
}
]
},
{
"id": "DerAnaesthesist.90480164.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"patients"
],
"offsets": [
[
220,
228
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0030705"
}
]
},
{
"id": "DerAnaesthesist.90480164.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"risk"
],
"offsets": [
[
232,
236
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0035647"
}
]
},
{
"id": "DerAnaesthesist.90480164.eng.abstr-s3-t3",
"type": "umlsterm",
"text": [
"aspiration"
],
"offsets": [
[
251,
261
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0004056"
},
{
"db_name": "UMLS",
"db_id": "C0004048"
}
]
},
{
"id": "DerAnaesthesist.90480164.eng.abstr-s4-t1",
"type": "umlsterm",
"text": [
"rocuronium"
],
"offsets": [
[
408,
418
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0209337"
}
]
}
] |
[] |
[] |
[
{
"id": "DerAnaesthesist.90480164.eng.abstr-s1-r1-t1.1-t4.1",
"type": "measures",
"arg1_id": "DerAnaesthesist.90480164.eng.abstr-s4-t1",
"arg2_id": "DerAnaesthesist.90480164.eng.abstr-s1-t4",
"normalized": []
},
{
"id": "DerAnaesthesist.90480164.eng.abstr-s1-r2-t1.1-t4.1",
"type": "uses",
"arg1_id": "DerAnaesthesist.90480164.eng.abstr-s4-t1",
"arg2_id": "DerAnaesthesist.90480164.eng.abstr-s1-t4",
"normalized": []
},
{
"id": "DerAnaesthesist.90480164.eng.abstr-s1-r3-t1.1-t2.1",
"type": "measures",
"arg1_id": "DerAnaesthesist.90480164.eng.abstr-s4-t1",
"arg2_id": "DerAnaesthesist.90480164.eng.abstr-s3-t2",
"normalized": []
},
{
"id": "DerAnaesthesist.90480164.eng.abstr-s1-r4-t1.1-t2.1",
"type": "uses",
"arg1_id": "DerAnaesthesist.90480164.eng.abstr-s4-t1",
"arg2_id": "DerAnaesthesist.90480164.eng.abstr-s3-t2",
"normalized": []
},
{
"id": "DerAnaesthesist.90480164.eng.abstr-s3-r2-t2.1-t3.1",
"type": "result_of",
"arg1_id": "DerAnaesthesist.90480164.eng.abstr-s3-t2",
"arg2_id": "DerAnaesthesist.90480164.eng.abstr-s3-t3",
"normalized": []
},
{
"id": "DerAnaesthesist.90480164.eng.abstr-s3-r3-t2.1-t3.1",
"type": "measurement_of",
"arg1_id": "DerAnaesthesist.90480164.eng.abstr-s3-t2",
"arg2_id": "DerAnaesthesist.90480164.eng.abstr-s3-t3",
"normalized": []
},
{
"id": "DerAnaesthesist.90480164.eng.abstr-s3-r5-t2.1-t3.2",
"type": "measurement_of",
"arg1_id": "DerAnaesthesist.90480164.eng.abstr-s3-t2",
"arg2_id": "DerAnaesthesist.90480164.eng.abstr-s3-t3",
"normalized": []
}
] |
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