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HNO.90470642.eng.abstr
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HNO.90470642.eng.abstr
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"Superficial leptomeningeal hemosiderosis is a rare disease of the central nervous system . Chronic bleeding into the subarachnoid space causes deposition of hemosiderin in glial cells and subsequent damage to adjacent brain tissue . There is a characteristic predilection for the cerebellum and eighth cranial nerve . Accordingly , among a variety of symptoms , cerebellar ataxia and sensorineural hearing loss progressing to total deafness commonly occur . To date , the hearing loss has been believed to be purely neural . We present a case of superficial hemosiderosis in a patient with total deafness who was successfully provided with a cochlear implant . Audiometry demonstrated total bilateral cochlear hearing losses but with preserved function of the eighth cranial nerve . These findings make us conclude that in contrast to current opinion , superficial hemosiderosis can initially damage the cochlea alone . Thus , patients with total deafness due to this disorder may benefit from cochlear implantation . All patients require careful audiometric assessment , including promontory stimulation ."
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] |
HNO.90470688.eng.abstr
|
HNO.90470688.eng.abstr
|
[
{
"id": "HNO.90470688.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Protruding ears are the most common auricular deformities for which patients seek consultation . These deformities belong to the first degree dysplasias and result from an overdeveloped concha , an underdeveloped anthelix or a prominent lobule . Otoplastic techniques to correct these malformations are based on such surgical principles as suturing , incision , excision , scoring and burring of the auricular cartilage . By emphasizing these basic procedures the most useful techniques are described . Special importance is placed on the indications for surgery , basic principles and techniques used ."
],
"offsets": [
[
0,
603
]
]
}
] |
[
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],
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[
11,
15
]
],
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{
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}
]
},
{
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],
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[
46,
57
]
],
"normalized": [
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}
]
},
{
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],
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68,
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]
],
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}
]
},
{
"id": "HNO.90470688.eng.abstr-s1-t4",
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],
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82,
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]
],
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] |
[] |
[] |
[
{
"id": "HNO.90470688.eng.abstr-s1-r1-t4.1-t2.1",
"type": "associated_with",
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{
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{
"id": "HNO.90470688.eng.abstr-s3-r1-t2.2-t1.1",
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},
{
"id": "HNO.90470688.eng.abstr-s5-r2-t2.1-t1.1",
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}
] |
HNO.90470695.eng.abstr
|
HNO.90470695.eng.abstr
|
[
{
"id": "HNO.90470695.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The objective of this trial was to analyse the predictive character of the angiogenic factors vascular endothelial growth factor ( VEGF ) , basic fibroblast growth factor ( bFGF ) and matrix metalloproteinase-2 ( MMP-2) in the sera of patients with advanced carcinomas of the head and neck treated by primary radiochemotherapy . From 1992 to 1995 , 25 patients with UICC stage cancers and one patient with stage III disease were treated in the departments of otolaryngology and radio-oncology of the University of Heidelberg according to a protocol of accelerated concomitant boost radiochemotherapy with carboplatin . The serum levels of VEGF , bFGF and MMP-2 were measured by enzyme-linked radiosorbent assay and data were correlated with followup findings ( median time of follow up : 60 months ) . Patients with serum levels above normal were detected for VEGF in 4 patients , MMP-2 in 7 patients and for bFGF in 13 patients . An increase in bFGF serum levels above the upper limit of normal controls was significantly associated with a shorter time of locoregional control ( P=0.036). In a covariate analysis bFGF proved to be independent of other prognostic factors , such as age , site , total tumor volume and response to therapy . No prognostic relevance of VEGF and MMP2 serum levels could be determined . The present suggest that bFGF is an independent prognostic factor for tumor control in advanced head and neck cancer after primary radiochemotherapy ."
],
"offsets": [
[
0,
1466
]
]
}
] |
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[] |
[] |
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] |
HNO.90470702.eng.abstr
|
HNO.90470702.eng.abstr
|
[
{
"id": "HNO.90470702.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Microsurgery of the larynx is commonly performed as direct laryngoscopy ( DL ) under general anesthesia . An alternative in selected cases is flexible laryngoscopy ( FSL ) under local anesthesia . We used a flexible laryngoscope that contained an additional working tunnel ( Olympus ENF Type T3). Local anaesthesia of the larynx was achieved with 1% oxybuprocaine-HCl . Tissue samples were taken under endoscopic view and control . Twenty-five patients were studied and had benign lesions of the larynx or were being followed after treatment for cancer . The examination was tolerated well by all patients . The handling of the endoscope allowed precise targeting and sample taking . Due to the 2.2 mm diameter of the forceps the sizes of the biopsies were also limited . However , nearly all of the biopsies taken allowed sufficient histological examination . The advantage of the FSL was its simplicity and the minor inconvenience for patients . Although true histological results of suspect findings are possible , limitations in examining the hypopharynx prevent true staging of cancer patients . In general , FCL is a worth-while complement to DL ."
],
"offsets": [
[
0,
1153
]
]
}
] |
[
{
"id": "HNO.90470702.eng.abstr-s1-t1",
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"Microsurgery"
],
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[
0,
12
]
],
"normalized": [
{
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"db_id": "C0026035"
}
]
},
{
"id": "HNO.90470702.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"larynx"
],
"offsets": [
[
20,
26
]
],
"normalized": [
{
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"db_id": "C0023078"
},
{
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] |
[] |
[] |
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"id": "HNO.90470702.eng.abstr-s11-r3-t1.1-t3.1",
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},
{
"id": "HNO.90470702.eng.abstr-s11-r4-t1.1-t2.1",
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"arg2_id": "HNO.90470702.eng.abstr-s11-t2",
"normalized": []
}
] |
HNO.90470706.eng.abstr
|
HNO.90470706.eng.abstr
|
[
{
"id": "HNO.90470706.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Vascular endothelial growth factor ( VEGF ) is one of the most potent factors in tumor-induced neoangiogenesis . After binding to its specific receptors KDR and FLT-1 on the endothelial cell surface cell proliferation and migration are stimulated . Recently there has been some evidence for the expression of these receptors on tumor cells . We investigated the protein and mRNA expression of KDR and FLT-1 in native tissues and tumor cell cultures from squamous cell carcinomas of the head and neck ( HNSCC ) and analyzed their in vitro functional significance for tumor cell proliferation and migration . Apart from the expected expression of VEGF receptors on endothelial cells we observed a tumor cell-specific localization of FLT-1 in 29 tumors and KDR in 16 of 37 tumors analyzed . Functional studies in vitro revealed that the addition of VEGF to HNSCC cells inhibited the proliferation and migration of these cells in a dose-dependent manner . Our data suggest a potential negative regulatory loop for VEGF and FLT1 when tumor cells have an insufficient blood supply ."
],
"offsets": [
[
0,
1076
]
]
}
] |
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{
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{
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{
"id": "HNO.90470706.eng.abstr-s4-t17",
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"id": "HNO.90470706.eng.abstr-s5-t7",
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}
]
}
] |
[] |
[] |
[
{
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"type": "produces",
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{
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},
{
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},
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},
{
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},
{
"id": "HNO.90470706.eng.abstr-s1-r7-t1.2-t2.1",
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},
{
"id": "HNO.90470706.eng.abstr-s1-r8-t1.2-t1.1",
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},
{
"id": "HNO.90470706.eng.abstr-s1-r9-t2.1-t1.1",
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},
{
"id": "HNO.90470706.eng.abstr-s3-r1-t2.1-t1.1",
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"normalized": []
},
{
"id": "HNO.90470706.eng.abstr-s4-r1-t3.1-t6.1",
"type": "surrounds",
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"normalized": []
},
{
"id": "HNO.90470706.eng.abstr-s4-r2-t2.1-t13.1",
"type": "disrupts",
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"arg2_id": "HNO.90470706.eng.abstr-s4-t13",
"normalized": []
},
{
"id": "HNO.90470706.eng.abstr-s4-r3-t13.1-t9.1",
"type": "location_of",
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{
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},
{
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},
{
"id": "HNO.90470706.eng.abstr-s4-r6-t11.1-t5.1",
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},
{
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},
{
"id": "HNO.90470706.eng.abstr-s4-r8-t14.1-t16.1",
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HNO.90470718.eng.abstr
|
HNO.90470718.eng.abstr
|
[
{
"id": "HNO.90470718.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The reliability of skin prick tests ( SPT ) may be insufficient for the screening of occupational inhalant allergies . The influence of different flour extracts on the SPT in flour allergic subjects has not been compared previously . In this study , SPT reactions against two commercially available rye and wheat flour extracts and individually prepared extracts from flour samples were compared in 35 patients with known bakers ' rhinitis . Flour sensitization was confirmed by a positive nasal provocation test ( NPT ) and/or serum-specific IgE . The sensitivity of NPT with a combination of rye and wheat flour extracts of individual flour samples was 94% . Wheat and/or rye flour specific IgE ( RAST > =2 ) was true positive in 86% . The sensitivity of the SPT was 94% for individual rye flour extracts compared to 38% and 59% for two commercially available rye flour extracts and 88% for individual wheat flour extract compared to 53% and 48% for commercially available wheat flour extracts . SPT and sIgE did not reveal a significant difference in prevalence between rye and wheat flour sensitization . Thirty healthy volunteers served as the control group . Three control subjects with histamine equivalent SPT reactions to grass pollen had a positive SPT reaction against individual flour extracts , whereas NPT with undiluted individual flour extracts was negative in all controls . SPT with individually prepared flour extracts appears to be sensitive for the demonstration of inhalant flour allergy . Our findings show that extracts of individual flour samples rather than commercially available extracts should be used for both SPT and NPT if flour allergy is suspected ."
],
"offsets": [
[
0,
1683
]
]
}
] |
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{
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{
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{
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{
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{
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"flour"
],
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[
313,
318
]
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}
]
},
{
"id": "HNO.90470718.eng.abstr-s3-t4",
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"flour"
],
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368,
373
]
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{
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402,
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{
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"text": [
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],
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},
{
"id": "HNO.90470718.eng.abstr-s4-t1",
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],
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]
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},
{
"id": "HNO.90470718.eng.abstr-s4-t3",
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"text": [
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] |
[] |
[] |
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"id": "HNO.90470718.eng.abstr-s12-r4-t1.1-t4.1",
"type": "affects",
"arg1_id": "HNO.90470718.eng.abstr-s12-t1",
"arg2_id": "HNO.90470718.eng.abstr-s12-t4",
"normalized": []
}
] |
HNO.90470723.eng.abstr
|
HNO.90470723.eng.abstr
|
[
{
"id": "HNO.90470723.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Tenascin is a glycoprotein of the extracellular matrix and is mainly expressed in association with a high proliferative and migratory activity . This characteristic has made it a successfully used target molecule in the treatment of glioblastoma . An application of anti-tenascin therapy concept in squamous cell carcinomas of the head and neck ( HNSCC ) mainly depends on the expression pattern of tenascin in a tumor type . In the present study , we analyzed the messenger ( m ) RNA and protein expression of tenascin in HNSCC tumors when compared to normal mucosa and determined its cellular localization and correlation with various clinical parameters , including tumor staging . In native tissue tenascin protein was localized in the entire extracellular matrix surrounding the tumor . Normal mucosa showed only a weak and interrupted basement membrane staining . In situ hybridization revealed a very faint tenascin mRNA signal in basal cells of normal mucosa and a strong signal in tumor cells . This tumor cell-specific expression of tenascin was confirmed at the protein level in HNSCC cultures . However , there was no correlation of tenascin expression with tumor staging or tumor cell proliferation . Our data clearly show that tenascin is selectively expressed in HNSCC and therefore could be useful for a therapeutic intervention in these tumors ."
],
"offsets": [
[
0,
1362
]
]
}
] |
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}
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{
"id": "HNO.90470723.eng.abstr-s1-t2",
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{
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{
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]
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{
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"id": "HNO.90470723.eng.abstr-s3-t1",
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{
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}
]
},
{
"id": "HNO.90470723.eng.abstr-s3-t3",
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}
]
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{
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{
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{
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"head"
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{
"id": "HNO.90470723.eng.abstr-s3-t7",
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"neck"
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{
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}
]
},
{
"id": "HNO.90470723.eng.abstr-s3-t10",
"type": "umlsterm",
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"squamous cell carcinomas"
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"id": "HNO.90470723.eng.abstr-s4-t1",
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"id": "HNO.90470723.eng.abstr-s4-t2",
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{
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{
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"id": "HNO.90470723.eng.abstr-s5-t1",
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{
"id": "HNO.90470723.eng.abstr-s5-t2",
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{
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{
"id": "HNO.90470723.eng.abstr-s6-t2",
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"membrane"
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{
"id": "HNO.90470723.eng.abstr-s6-t3",
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}
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{
"id": "HNO.90470723.eng.abstr-s7-t1",
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}
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{
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{
"id": "HNO.90470723.eng.abstr-s7-t4",
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{
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{
"id": "HNO.90470723.eng.abstr-s9-t5",
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},
{
"id": "HNO.90470723.eng.abstr-s10-t2",
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]
},
{
"id": "HNO.90470723.eng.abstr-s10-t3",
"type": "umlsterm",
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{
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"db_id": "C0027651"
}
]
}
] |
[] |
[] |
[
{
"id": "HNO.90470723.eng.abstr-s1-r1-t4.1-t2.1",
"type": "produces",
"arg1_id": "HNO.90470723.eng.abstr-s9-t4",
"arg2_id": "HNO.90470723.eng.abstr-s10-t2",
"normalized": []
},
{
"id": "HNO.90470723.eng.abstr-s1-r2-t1.1-t4.1",
"type": "disrupts",
"arg1_id": "HNO.90470723.eng.abstr-s10-t1",
"arg2_id": "HNO.90470723.eng.abstr-s9-t4",
"normalized": []
},
{
"id": "HNO.90470723.eng.abstr-s1-r3-t1.1-t2.1",
"type": "interacts_with",
"arg1_id": "HNO.90470723.eng.abstr-s10-t1",
"arg2_id": "HNO.90470723.eng.abstr-s10-t2",
"normalized": []
},
{
"id": "HNO.90470723.eng.abstr-s1-r4-t3.1-t1.1",
"type": "produces",
"arg1_id": "HNO.90470723.eng.abstr-s10-t3",
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"normalized": []
},
{
"id": "HNO.90470723.eng.abstr-s1-r5-t1.1-t3.1",
"type": "affects",
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"normalized": []
},
{
"id": "HNO.90470723.eng.abstr-s1-r6-t4.1-t3.1",
"type": "location_of",
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},
{
"id": "HNO.90470723.eng.abstr-s1-r7-t4.1-t1.1",
"type": "produces",
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"normalized": []
},
{
"id": "HNO.90470723.eng.abstr-s1-r8-t2.1-t3.1",
"type": "affects",
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},
{
"id": "HNO.90470723.eng.abstr-s1-r9-t2.1-t1.1",
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] |
HNO.90470730.eng.abstr
|
HNO.90470730.eng.abstr
|
[
{
"id": "HNO.90470730.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Background : Workers in the construction industry carry an increased risk for head and neck cancer due to the high consumption of alcohol and tobacco plus exposure to occupational carcinogenic or co-carcinogenic agents . These latter substances include asbestos , tar products , metal dust , wood dust , cement dust and paints ."
],
"offsets": [
[
0,
328
]
]
}
] |
[
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{
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{
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{
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},
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},
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},
{
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},
{
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},
{
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},
{
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},
{
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},
{
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},
{
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]
},
{
"id": "HNO.90470730.eng.abstr-s2-t8",
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326
]
],
"normalized": [
{
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"db_id": "C0030206"
}
]
}
] |
[] |
[] |
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] |
HNO.90470737.eng.abstr
|
HNO.90470737.eng.abstr
|
[
{
"id": "HNO.90470737.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Epidermoid cysts are rare lesions in the head and neck . Most often the are located in the submental region , although they sometimes can impose certain diagnostic problems . We report the case of a 19-year-old girl who presented with a fluctuant , painless , midline swelling of the floor of her mouth that had persisted for three months . Ultrasonographic examination showed a 5x5x4 cm cystic tumor with the unusual aspect of multiple smaller spherical formations . The differential diagnosis of the lesion included dermoid cysts , epidermoid cysts , ranula and parasitic lesions . Computed tomography and magnetic resonance tomography were not diagnostic . The patient underwent excision of the lesion , during which the cyst was completely removed . Histopathological diagnosis was consistent with an epidermoid cyst . The striking sonographic aspect of multiple spherical formations in the lesion was caused by multiple spherical keratin formations ."
],
"offsets": [
[
0,
955
]
]
}
] |
[
{
"id": "HNO.90470737.eng.abstr-s1-t1",
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"text": [
"cysts"
],
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[
11,
16
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0010709"
}
]
},
{
"id": "HNO.90470737.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"head"
],
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[
41,
45
]
],
"normalized": [
{
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"db_id": "C0018670"
}
]
},
{
"id": "HNO.90470737.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"neck"
],
"offsets": [
[
50,
54
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0027530"
}
]
},
{
"id": "HNO.90470737.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"Epidermoid cysts"
],
"offsets": [
[
0,
16
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0014511"
}
]
},
{
"id": "HNO.90470737.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"diagnostic"
],
"offsets": [
[
153,
163
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0348026"
}
]
},
{
"id": "HNO.90470737.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"midline"
],
"offsets": [
[
260,
267
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0677502"
}
]
},
{
"id": "HNO.90470737.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"floor"
],
"offsets": [
[
284,
289
]
],
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{
"db_name": "UMLS",
"db_id": "C0016249"
}
]
},
{
"id": "HNO.90470737.eng.abstr-s3-t3",
"type": "umlsterm",
"text": [
"mouth"
],
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[
297,
302
]
],
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{
"db_name": "UMLS",
"db_id": "C0153381"
},
{
"db_name": "UMLS",
"db_id": "C0226896"
}
]
},
{
"id": "HNO.90470737.eng.abstr-s4-t1",
"type": "umlsterm",
"text": [
"tumor"
],
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[
395,
400
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0027651"
}
]
},
{
"id": "HNO.90470737.eng.abstr-s5-t1",
"type": "umlsterm",
"text": [
"diagnosis"
],
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[
485,
494
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0011900"
},
{
"db_name": "UMLS",
"db_id": "C0348026"
}
]
},
{
"id": "HNO.90470737.eng.abstr-s5-t2",
"type": "umlsterm",
"text": [
"dermoid"
],
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[
518,
525
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0011649"
}
]
},
{
"id": "HNO.90470737.eng.abstr-s5-t3",
"type": "umlsterm",
"text": [
"cysts"
],
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[
526,
531
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0010709"
}
]
},
{
"id": "HNO.90470737.eng.abstr-s5-t4",
"type": "umlsterm",
"text": [
"cysts"
],
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[
545,
550
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0010709"
}
]
},
{
"id": "HNO.90470737.eng.abstr-s5-t5",
"type": "umlsterm",
"text": [
"ranula"
],
"offsets": [
[
553,
559
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0034666"
}
]
},
{
"id": "HNO.90470737.eng.abstr-s5-t6",
"type": "umlsterm",
"text": [
"parasitic"
],
"offsets": [
[
564,
573
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0521066"
}
]
},
{
"id": "HNO.90470737.eng.abstr-s5-t7",
"type": "umlsterm",
"text": [
"differential diagnosis"
],
"offsets": [
[
472,
494
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0220820"
},
{
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"db_id": "C0011906"
}
]
},
{
"id": "HNO.90470737.eng.abstr-s5-t8",
"type": "umlsterm",
"text": [
"dermoid cysts"
],
"offsets": [
[
518,
531
]
],
"normalized": [
{
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"db_id": "C0011649"
}
]
},
{
"id": "HNO.90470737.eng.abstr-s5-t9",
"type": "umlsterm",
"text": [
"epidermoid cysts"
],
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[
534,
550
]
],
"normalized": [
{
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"db_id": "C0014511"
}
]
},
{
"id": "HNO.90470737.eng.abstr-s6-t1",
"type": "umlsterm",
"text": [
"tomography"
],
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[
593,
603
]
],
"normalized": [
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"db_id": "C0040395"
}
]
},
{
"id": "HNO.90470737.eng.abstr-s6-t2",
"type": "umlsterm",
"text": [
"magnetic"
],
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[
608,
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]
],
"normalized": [
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"db_id": "C0024488"
}
]
},
{
"id": "HNO.90470737.eng.abstr-s6-t3",
"type": "umlsterm",
"text": [
"resonance"
],
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[
617,
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]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0459800"
}
]
},
{
"id": "HNO.90470737.eng.abstr-s6-t4",
"type": "umlsterm",
"text": [
"tomography"
],
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[
627,
637
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0040395"
}
]
},
{
"id": "HNO.90470737.eng.abstr-s6-t5",
"type": "umlsterm",
"text": [
"diagnostic"
],
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[
647,
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]
],
"normalized": [
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"db_name": "UMLS",
"db_id": "C0348026"
}
]
},
{
"id": "HNO.90470737.eng.abstr-s6-t6",
"type": "umlsterm",
"text": [
"Computed tomography"
],
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[
584,
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],
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}
]
},
{
"id": "HNO.90470737.eng.abstr-s6-t7",
"type": "umlsterm",
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"magnetic resonance"
],
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[
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]
],
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"db_id": "C0917874"
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]
},
{
"id": "HNO.90470737.eng.abstr-s7-t1",
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"patient"
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]
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]
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{
"id": "HNO.90470737.eng.abstr-s7-t2",
"type": "umlsterm",
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"cyst"
],
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[
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]
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]
},
{
"id": "HNO.90470737.eng.abstr-s8-t1",
"type": "umlsterm",
"text": [
"Histopathological"
],
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[
754,
771
]
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"db_id": "C0243140"
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]
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{
"id": "HNO.90470737.eng.abstr-s8-t2",
"type": "umlsterm",
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"diagnosis"
],
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]
},
{
"id": "HNO.90470737.eng.abstr-s8-t3",
"type": "umlsterm",
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"cyst"
],
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]
],
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}
]
},
{
"id": "HNO.90470737.eng.abstr-s8-t4",
"type": "umlsterm",
"text": [
"epidermoid cyst"
],
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[
805,
820
]
],
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{
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"db_id": "C0014511"
}
]
},
{
"id": "HNO.90470737.eng.abstr-s9-t1",
"type": "umlsterm",
"text": [
"keratin"
],
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[
935,
942
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0022564"
}
]
}
] |
[] |
[] |
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HNO.90470741.eng.abstr
|
HNO.90470741.eng.abstr
|
[
{
"id": "HNO.90470741.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A 22-year-old male presented with a submandibular cystic mass in the ENT Clinic of Berlin-Buch . Histopathology revealed a dystopic papillary carcinoma in a thyroglossal duct cyst . Worldwide only about 150 cases are known . We describe our diagnostic and therapeutic procedures employed and included tumor excision , bilateral neck dissections and total thyroidectomy . No abnormalities in the thyroid gland but a metastatic carcinoma was uncovered in an ipsilateral lymph node in the jugular foramen area . A preoperative 99 Tc-thyroid scan and MRI study had not shown any evidence for a malignant tumor . The therapeutic approach advocated in literature is controversial but the intraoperative findings in our patient supported our decision to choose a relatively radical but not mutilating therapy ."
],
"offsets": [
[
0,
803
]
]
}
] |
[
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]
},
{
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{
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{
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{
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{
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{
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{
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},
{
"id": "HNO.90470741.eng.abstr-s4-t4",
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{
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] |
[] |
[] |
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] |
HNO.90470787.eng.abstr
|
HNO.90470787.eng.abstr
|
[
{
"id": "HNO.90470787.eng.abstr-passage-0",
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"Category loudness scaling was used to investigate the loudness perception of 31 patients with a cochlear hearing loss ( Group 1 ) by comparing the results with those found in 15 patients with retro-cochlear hearing loss caused by an acoustic neuroma ( Group 2 ) . Narrow-band noise signals at four different frequencies ( 0.5 to 4.0 kHz ) were used . In the cochlear hearing-impaired subjects the slopes of the level-loudness functions tended to increase with increasing hearing loss , indicating positive recruitment , whereas the much shallower slopes associated with retro-cochlear lesions were presumed to reflect negative recruitment . The graphic representation of the iso-loudness functions revealed a different dynamic range between Group 1 and 2 with the ability to discriminate small differences of stimulus levels reduced in the presence of an acoustic neuroma . Category loudness scaling has been shown to be a valuable tool describing the individual perception of sound in a qualitative and quantitative manner . Furthermore , the method can be employed as an indicator of recruitment without any restrictive preconditions . For this reason the categorial loudness scaling can be a desirable method for supplementing the audiological diagnosis of a retro-cochlear hearing impairment through the frequency-specific description of a usable hearing-field and its dynamic range ."
],
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0,
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}
] |
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] |
[] |
[] |
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HNO.90470796.eng.abstr
|
HNO.90470796.eng.abstr
|
[
{
"id": "HNO.90470796.eng.abstr-passage-0",
"type": "abstract",
"text": [
"In order to identify squamous cell carcinomas of the head and neck ( HNSCC ) with common biological and clinical features , we investigated the incidence and properties of carcinomas lacking retinoblastoma protein ( pR6) cell cycle control . Of 208 HNSCC investigated , 23 ( 11% ) showed a lack of pRb expression . The majority of these tumors ( 65% ) were tonsillar carcinomas . The pRb-negative tonsillar tumors were all stage IV , had metastasized to lymph nodes at the time of diagnosis and were in general poorly differentiated or undifferentiated . Very significantly , the pRb-negative phenotype was strongly associated with the presence of oncogenic human papilloma viruses , implying a viral etiology and functional inactivation of pRb by the viral E7 oncoprotein . Despite the very adverse histopathological factors , patients with pRb-negative tonsillar carcinomas had a better clinical outcome , which was consistent with a uniform favorable responsiveness of these tumors to postoperative radiation therapy ."
],
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0,
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]
}
] |
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}
] |
[] |
[] |
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] |
HNO.90470804.eng.abstr
|
HNO.90470804.eng.abstr
|
[
{
"id": "HNO.90470804.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The established criteria of auditory brainstem responses ( ABR ) such as JV latency , JI-V interpeak latency and interaural differences of latency or amplitude have been found to be sensitive for detecting tumors of the cerebellopontine angle if a response is present . However , the ABR can be absent in cases of acoustic neuromas because of desynchronization , even though pure-one audiometry indicates that responses should be present . This retrospective study compared the ABR and pure-tone thresholds in 234 cases with cerebellopontine angle tumors and a control group of 181 cases with sensory hearing losses in order to quantify threshold discrepancies . The average deficit of the objective ABR threshold ( DOABRT ) to the subjective pure-tone threshold for those frequencies between 1-6 kHz was 3.6 dB for the control group ( ABR and pure tone thresholds very close ) and 31.2 dB for the tumor group ( ABR threshold much higher than the pure-tone threshold ) . ABR thresholds 30 dB higher than the high-frequency pure tone thresholds were found in 40.6% of the tumor group and in none of the control group . Thus , deficits of the ABR threshold > 30 dB can be considered to be an additional criterion for detecting retrocochlear disease and increases ABR sensitivity for tumor detection even if responses are absent ."
],
"offsets": [
[
0,
1327
]
]
}
] |
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] |
[] |
[] |
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},
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},
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},
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},
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},
{
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"normalized": []
}
] |
HNO.90470816.eng.abstr
|
HNO.90470816.eng.abstr
|
[
{
"id": "HNO.90470816.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Bilateral glomus jugulare tumors are rare . However , their treatment should preserve not only the function of the facial nerve but also the caudal cranial nerves and the middle ears in order to avoid bilateral hearing losses . Further , venous cerebral drainage has to be ensured in order to avoid cerebral hypertension and hemorrhagic infarction after bilateral jugular ligations . In the case presented bilateral glomus jugulare tumors required super-selective angiography and embolization . Complete tumor removal on both sides was then possible by a transmastoid-transcervical approach without any further functional deteriorations . Middle ear function was preserved on both sides by temporary ventral translocation of the posterior wall of the auditory meatus . As the sigmoid sinus and internal jugular vein had been ligated during initial previous surgery , venous drainage was tested one year later by angiography and compression of the remaining internal jugular vein . A sufficient collateral circulation was found and permitted surgery on the second side ."
],
"offsets": [
[
0,
1069
]
]
}
] |
[
{
"id": "HNO.90470816.eng.abstr-s1-t1",
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"tumors"
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26,
32
]
],
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"db_id": "C0027651"
}
]
},
{
"id": "HNO.90470816.eng.abstr-s1-t2",
"type": "umlsterm",
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"glomus jugulare"
],
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10,
25
]
],
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{
"id": "HNO.90470816.eng.abstr-s1-t3",
"type": "umlsterm",
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"glomus jugulare tumors"
],
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[
10,
32
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]
},
{
"id": "HNO.90470816.eng.abstr-s2-t1",
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69
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}
]
},
{
"id": "HNO.90470816.eng.abstr-s2-t2",
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"function"
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107
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}
]
},
{
"id": "HNO.90470816.eng.abstr-s2-t3",
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"nerve"
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122,
127
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],
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},
{
"id": "HNO.90470816.eng.abstr-s2-t4",
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"nerves"
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]
},
{
"id": "HNO.90470816.eng.abstr-s2-t5",
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],
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182
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}
]
},
{
"id": "HNO.90470816.eng.abstr-s2-t6",
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"hearing"
],
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211,
218
]
],
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}
]
},
{
"id": "HNO.90470816.eng.abstr-s2-t7",
"type": "umlsterm",
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"facial nerve"
],
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115,
127
]
],
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"db_id": "C0015462"
}
]
},
{
"id": "HNO.90470816.eng.abstr-s2-t8",
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"cranial nerves"
],
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148,
162
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}
]
},
{
"id": "HNO.90470816.eng.abstr-s2-t9",
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"middle ears"
],
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171,
182
]
],
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]
},
{
"id": "HNO.90470816.eng.abstr-s2-t10",
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"hearing losses"
],
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211,
225
]
],
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}
]
},
{
"id": "HNO.90470816.eng.abstr-s2-t11",
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],
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201,
225
]
],
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}
]
},
{
"id": "HNO.90470816.eng.abstr-s3-t1",
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254,
262
]
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}
]
},
{
"id": "HNO.90470816.eng.abstr-s3-t2",
"type": "umlsterm",
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"hypertension"
],
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]
],
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]
},
{
"id": "HNO.90470816.eng.abstr-s3-t3",
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],
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]
},
{
"id": "HNO.90470816.eng.abstr-s3-t4",
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],
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]
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]
},
{
"id": "HNO.90470816.eng.abstr-s4-t1",
"type": "umlsterm",
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]
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]
},
{
"id": "HNO.90470816.eng.abstr-s4-t2",
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}
]
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{
"id": "HNO.90470816.eng.abstr-s4-t3",
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"embolization"
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]
},
{
"id": "HNO.90470816.eng.abstr-s4-t4",
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]
},
{
"id": "HNO.90470816.eng.abstr-s4-t5",
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],
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{
"id": "HNO.90470816.eng.abstr-s5-t1",
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{
"id": "HNO.90470816.eng.abstr-s6-t1",
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{
"id": "HNO.90470816.eng.abstr-s6-t3",
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{
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{
"id": "HNO.90470816.eng.abstr-s6-t5",
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{
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]
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{
"id": "HNO.90470816.eng.abstr-s7-t2",
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"sinus"
],
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]
},
{
"id": "HNO.90470816.eng.abstr-s7-t3",
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{
"id": "HNO.90470816.eng.abstr-s7-t4",
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]
},
{
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]
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{
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{
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]
},
{
"id": "HNO.90470816.eng.abstr-s7-t8",
"type": "umlsterm",
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"jugular vein"
],
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803,
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]
],
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]
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{
"id": "HNO.90470816.eng.abstr-s7-t9",
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{
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]
},
{
"id": "HNO.90470816.eng.abstr-s8-t3",
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],
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"db_id": "C0009348"
}
]
}
] |
[] |
[] |
[
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},
{
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{
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{
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{
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},
{
"id": "HNO.90470816.eng.abstr-s2-r12-t10.1-t8.2",
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},
{
"id": "HNO.90470816.eng.abstr-s2-r13-t8.2-t10.1",
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},
{
"id": "HNO.90470816.eng.abstr-s2-r14-t8.2-t10.1",
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},
{
"id": "HNO.90470816.eng.abstr-s2-r15-t11.1-t4.1",
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{
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}
] |
HNO.90470821.eng.abstr
|
HNO.90470821.eng.abstr
|
[
{
"id": "HNO.90470821.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Cervical thymic cysts belong to the rare causes of neck masses and therefore are frequently not included in a preoperative differental diagnosis . Here we report our experience in managing a 7-year-old boy who presented with a three-month history of a lateral neck mass causing stridor during sleep . Clinical findings and macroscopic and histopathological features are described and reviewed with respect to the available literature . The inclusion of a cervical thymic cyst in a preoperative differential diagnosis is important for determining the extent of the neck mass and planning any surgical procedure ."
],
"offsets": [
[
0,
611
]
]
}
] |
[
{
"id": "HNO.90470821.eng.abstr-s1-t1",
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"text": [
"cysts"
],
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[
16,
21
]
],
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{
"db_name": "UMLS",
"db_id": "C0010709"
}
]
},
{
"id": "HNO.90470821.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"causes"
],
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[
41,
47
]
],
"normalized": [
{
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"db_id": "C0015127"
}
]
},
{
"id": "HNO.90470821.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"neck"
],
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[
51,
55
]
],
"normalized": [
{
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}
]
},
{
"id": "HNO.90470821.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"diagnosis"
],
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[
135,
144
]
],
"normalized": [
{
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"db_id": "C0011900"
},
{
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}
]
},
{
"id": "HNO.90470821.eng.abstr-s1-t5",
"type": "umlsterm",
"text": [
"thymic cysts"
],
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[
9,
21
]
],
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{
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"db_id": "C0040072"
}
]
},
{
"id": "HNO.90470821.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"history"
],
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[
239,
246
]
],
"normalized": [
{
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"db_id": "C0019664"
},
{
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}
]
},
{
"id": "HNO.90470821.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"neck"
],
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[
260,
264
]
],
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{
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}
]
},
{
"id": "HNO.90470821.eng.abstr-s2-t3",
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"text": [
"stridor"
],
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[
278,
285
]
],
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{
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"db_id": "C0038450"
}
]
},
{
"id": "HNO.90470821.eng.abstr-s2-t4",
"type": "umlsterm",
"text": [
"sleep"
],
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[
293,
298
]
],
"normalized": [
{
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"db_id": "C0037313"
}
]
},
{
"id": "HNO.90470821.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"findings"
],
"offsets": [
[
310,
318
]
],
"normalized": [
{
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"db_id": "C0243095"
}
]
},
{
"id": "HNO.90470821.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"histopathological"
],
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[
339,
356
]
],
"normalized": [
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}
]
},
{
"id": "HNO.90470821.eng.abstr-s3-t3",
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"text": [
"literature"
],
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[
423,
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]
],
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}
]
},
{
"id": "HNO.90470821.eng.abstr-s4-t1",
"type": "umlsterm",
"text": [
"cyst"
],
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[
471,
475
]
],
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{
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}
]
},
{
"id": "HNO.90470821.eng.abstr-s4-t2",
"type": "umlsterm",
"text": [
"diagnosis"
],
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[
507,
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]
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},
{
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}
]
},
{
"id": "HNO.90470821.eng.abstr-s4-t3",
"type": "umlsterm",
"text": [
"neck"
],
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[
564,
568
]
],
"normalized": [
{
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}
]
},
{
"id": "HNO.90470821.eng.abstr-s4-t4",
"type": "umlsterm",
"text": [
"surgical"
],
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[
591,
599
]
],
"normalized": [
{
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}
]
},
{
"id": "HNO.90470821.eng.abstr-s4-t5",
"type": "umlsterm",
"text": [
"procedure"
],
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[
600,
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]
],
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}
]
},
{
"id": "HNO.90470821.eng.abstr-s4-t6",
"type": "umlsterm",
"text": [
"thymic cyst"
],
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[
464,
475
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0040072"
}
]
},
{
"id": "HNO.90470821.eng.abstr-s4-t7",
"type": "umlsterm",
"text": [
"differential diagnosis"
],
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[
494,
516
]
],
"normalized": [
{
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"db_id": "C0220820"
},
{
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}
]
},
{
"id": "HNO.90470821.eng.abstr-s4-t8",
"type": "umlsterm",
"text": [
"surgical procedure"
],
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[
591,
609
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0543467"
}
]
}
] |
[] |
[] |
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{
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{
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{
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{
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{
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{
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}
] |
HNO.90470825.eng.abstr
|
HNO.90470825.eng.abstr
|
[
{
"id": "HNO.90470825.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A case is reported of a 57-year-old man who was found to have a right vocal cord paralysis that most likely followed prolonged treatment with the anti-arrythmic medication Amiodaron-HCl ( Cordarex ) . Phoniatric treatment was given for 5 1/2 months , during which time microlaryngoscopy and stroboscopy were performed . With the help of speech therapy , mobility of the paralyzed cord was seen to begin to return 3 1/2 months after discontinuing the Amiodaron-HCl . Full cord mobility has not returned to date ."
],
"offsets": [
[
0,
511
]
]
}
] |
[
{
"id": "HNO.90470825.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"man"
],
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[
36,
39
]
],
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{
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"db_id": "C0025266"
},
{
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"db_id": "C0024554"
}
]
},
{
"id": "HNO.90470825.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"right"
],
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[
64,
69
]
],
"normalized": [
{
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"db_id": "C0035621"
}
]
},
{
"id": "HNO.90470825.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"paralysis"
],
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[
81,
90
]
],
"normalized": [
{
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"db_id": "C0030440"
}
]
},
{
"id": "HNO.90470825.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"treatment"
],
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[
127,
136
]
],
"normalized": [
{
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"db_id": "C0087111"
},
{
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}
]
},
{
"id": "HNO.90470825.eng.abstr-s1-t5",
"type": "umlsterm",
"text": [
"medication"
],
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[
161,
171
]
],
"normalized": [
{
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"db_id": "C0013227"
}
]
},
{
"id": "HNO.90470825.eng.abstr-s1-t6",
"type": "umlsterm",
"text": [
"vocal cord"
],
"offsets": [
[
70,
80
]
],
"normalized": [
{
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"db_id": "C0042930"
}
]
},
{
"id": "HNO.90470825.eng.abstr-s1-t7",
"type": "umlsterm",
"text": [
"vocal cord paralysis"
],
"offsets": [
[
70,
90
]
],
"normalized": [
{
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"db_id": "C0042928"
}
]
},
{
"id": "HNO.90470825.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"treatment"
],
"offsets": [
[
212,
221
]
],
"normalized": [
{
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"db_id": "C0087111"
},
{
"db_name": "UMLS",
"db_id": "C0039798"
}
]
},
{
"id": "HNO.90470825.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"time"
],
"offsets": [
[
264,
268
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0040223"
}
]
},
{
"id": "HNO.90470825.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"speech"
],
"offsets": [
[
337,
343
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0037817"
}
]
},
{
"id": "HNO.90470825.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"therapy"
],
"offsets": [
[
344,
351
]
],
"normalized": [
{
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"db_id": "C0087111"
},
{
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}
]
},
{
"id": "HNO.90470825.eng.abstr-s3-t3",
"type": "umlsterm",
"text": [
"speech therapy"
],
"offsets": [
[
337,
351
]
],
"normalized": [
{
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"db_id": "C0037831"
}
]
},
{
"id": "HNO.90470825.eng.abstr-s4-t1",
"type": "umlsterm",
"text": [
"date"
],
"offsets": [
[
505,
509
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0011008"
}
]
}
] |
[] |
[] |
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{
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{
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},
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},
{
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},
{
"id": "HNO.90470825.eng.abstr-s1-r18-t4.1-t1.2",
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},
{
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}
] |
HNO.90470867.eng.abstr
|
HNO.90470867.eng.abstr
|
[
{
"id": "HNO.90470867.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Hiccup is defined as involuntary contractions of the diaphragm and the auxiliary respiratory muscles , mostly in irregular series , followed by glottic closure , thereby producing a typical \" hiccuping \" inspiration . This is a physiologic phenomenon , which already exists in utero . Hiccup is believed to be a gastrointestinal reflex ; however , function and the reflex arch are hypothetical . Acute hiccup is distinguished from pathological , chronic hiccup , defined by a duration execuiding 48 h , or recurrent episodes . Among approximately 100 causes for hiccup , the most common are located in the gastrointestinal tract , with gastro-esophageal reflux as the most important . While the respiratory effect is generally negligible , alkalosis may ensue in tracheotomized patients due to hyperventilation . A stepwise management plan for patients with hiccup is presented . If simple physical maneuvers and causal therapy fail , or causal therapy is impossible , the treatment of choice is medical , with baclofen . Interruption of the reflex arch may be causal therapy or be considered as a last resort ."
],
"offsets": [
[
0,
1111
]
]
}
] |
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{
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{
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{
"id": "HNO.90470867.eng.abstr-s3-t4",
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{
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{
"id": "HNO.90470867.eng.abstr-s6-t3",
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{
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"therapy"
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{
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"choice"
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}
]
},
{
"id": "HNO.90470867.eng.abstr-s8-t5",
"type": "umlsterm",
"text": [
"baclofen"
],
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},
{
"id": "HNO.90470867.eng.abstr-s9-t1",
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"reflex"
],
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}
]
},
{
"id": "HNO.90470867.eng.abstr-s9-t3",
"type": "umlsterm",
"text": [
"resort"
],
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[
1103,
1109
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0035198"
}
]
}
] |
[] |
[] |
[
{
"id": "HNO.90470867.eng.abstr-s1-r1-t3.1-t5.1",
"type": "developmental_form_of",
"arg1_id": "HNO.90470867.eng.abstr-s9-t3",
"arg2_id": "HNO.90470867.eng.abstr-s8-t5",
"normalized": []
},
{
"id": "HNO.90470867.eng.abstr-s1-r2-t5.1-t3.1",
"type": "surrounds",
"arg1_id": "HNO.90470867.eng.abstr-s8-t5",
"arg2_id": "HNO.90470867.eng.abstr-s9-t3",
"normalized": []
},
{
"id": "HNO.90470867.eng.abstr-s1-r3-t3.1-t2.1",
"type": "developmental_form_of",
"arg1_id": "HNO.90470867.eng.abstr-s9-t3",
"arg2_id": "HNO.90470867.eng.abstr-s9-t2",
"normalized": []
},
{
"id": "HNO.90470867.eng.abstr-s1-r4-t2.1-t3.1",
"type": "surrounds",
"arg1_id": "HNO.90470867.eng.abstr-s9-t2",
"arg2_id": "HNO.90470867.eng.abstr-s9-t3",
"normalized": []
},
{
"id": "HNO.90470867.eng.abstr-s1-r5-t2.1-t1.1",
"type": "treats",
"arg1_id": "HNO.90470867.eng.abstr-s9-t2",
"arg2_id": "HNO.90470867.eng.abstr-s9-t1",
"normalized": []
},
{
"id": "HNO.90470867.eng.abstr-s1-r6-t2.1-t4.1",
"type": "location_of",
"arg1_id": "HNO.90470867.eng.abstr-s9-t2",
"arg2_id": "HNO.90470867.eng.abstr-s8-t4",
"normalized": []
},
{
"id": "HNO.90470867.eng.abstr-s1-r7-t5.1-t4.1",
"type": "location_of",
"arg1_id": "HNO.90470867.eng.abstr-s8-t5",
"arg2_id": "HNO.90470867.eng.abstr-s8-t4",
"normalized": []
},
{
"id": "HNO.90470867.eng.abstr-s1-r8-t3.1-t4.1",
"type": "location_of",
"arg1_id": "HNO.90470867.eng.abstr-s9-t3",
"arg2_id": "HNO.90470867.eng.abstr-s8-t4",
"normalized": []
},
{
"id": "HNO.90470867.eng.abstr-s1-r9-t1.1-t4.1",
"type": "evaluation_of",
"arg1_id": "HNO.90470867.eng.abstr-s9-t1",
"arg2_id": "HNO.90470867.eng.abstr-s8-t4",
"normalized": []
},
{
"id": "HNO.90470867.eng.abstr-s3-r1-t1.1-t3.1",
"type": "evaluation_of",
"arg1_id": "HNO.90470867.eng.abstr-s9-t1",
"arg2_id": "HNO.90470867.eng.abstr-s9-t3",
"normalized": []
},
{
"id": "HNO.90470867.eng.abstr-s3-r2-t3.1-t2.1",
"type": "result_of",
"arg1_id": "HNO.90470867.eng.abstr-s9-t3",
"arg2_id": "HNO.90470867.eng.abstr-s9-t2",
"normalized": []
},
{
"id": "HNO.90470867.eng.abstr-s3-r3-t1.1-t2.1",
"type": "evaluation_of",
"arg1_id": "HNO.90470867.eng.abstr-s9-t1",
"arg2_id": "HNO.90470867.eng.abstr-s9-t2",
"normalized": []
},
{
"id": "HNO.90470867.eng.abstr-s3-r4-t2.1-t3.1",
"type": "result_of",
"arg1_id": "HNO.90470867.eng.abstr-s9-t2",
"arg2_id": "HNO.90470867.eng.abstr-s9-t3",
"normalized": []
},
{
"id": "HNO.90470867.eng.abstr-s5-r1-t3.1-t1.1",
"type": "associated_with",
"arg1_id": "HNO.90470867.eng.abstr-s9-t3",
"arg2_id": "HNO.90470867.eng.abstr-s9-t1",
"normalized": []
},
{
"id": "HNO.90470867.eng.abstr-s5-r2-t1.1-t3.1",
"type": "associated_with",
"arg1_id": "HNO.90470867.eng.abstr-s9-t1",
"arg2_id": "HNO.90470867.eng.abstr-s9-t3",
"normalized": []
},
{
"id": "HNO.90470867.eng.abstr-s6-r1-t3.1-t2.1",
"type": "occurs_in",
"arg1_id": "HNO.90470867.eng.abstr-s9-t3",
"arg2_id": "HNO.90470867.eng.abstr-s9-t2",
"normalized": []
},
{
"id": "HNO.90470867.eng.abstr-s6-r2-t3.1-t1.1",
"type": "associated_with",
"arg1_id": "HNO.90470867.eng.abstr-s9-t3",
"arg2_id": "HNO.90470867.eng.abstr-s9-t1",
"normalized": []
},
{
"id": "HNO.90470867.eng.abstr-s6-r3-t3.1-t1.1",
"type": "degree_of",
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"arg2_id": "HNO.90470867.eng.abstr-s9-t1",
"normalized": []
},
{
"id": "HNO.90470867.eng.abstr-s6-r4-t1.1-t2.1",
"type": "occurs_in",
"arg1_id": "HNO.90470867.eng.abstr-s9-t1",
"arg2_id": "HNO.90470867.eng.abstr-s9-t2",
"normalized": []
},
{
"id": "HNO.90470867.eng.abstr-s6-r5-t1.1-t3.1",
"type": "associated_with",
"arg1_id": "HNO.90470867.eng.abstr-s9-t1",
"arg2_id": "HNO.90470867.eng.abstr-s9-t3",
"normalized": []
},
{
"id": "HNO.90470867.eng.abstr-s6-r6-t1.1-t3.1",
"type": "degree_of",
"arg1_id": "HNO.90470867.eng.abstr-s9-t1",
"arg2_id": "HNO.90470867.eng.abstr-s9-t3",
"normalized": []
},
{
"id": "HNO.90470867.eng.abstr-s7-r1-t3.1-t1.1",
"type": "evaluation_of",
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"arg2_id": "HNO.90470867.eng.abstr-s9-t1",
"normalized": []
},
{
"id": "HNO.90470867.eng.abstr-s9-r1-t2.1-t3.1",
"type": "uses",
"arg1_id": "HNO.90470867.eng.abstr-s9-t2",
"arg2_id": "HNO.90470867.eng.abstr-s9-t3",
"normalized": []
},
{
"id": "HNO.90470867.eng.abstr-s9-r2-t3.1-t2.1",
"type": "carries_out",
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"arg2_id": "HNO.90470867.eng.abstr-s9-t2",
"normalized": []
},
{
"id": "HNO.90470867.eng.abstr-s9-r3-t2.1-t1.1",
"type": "affects",
"arg1_id": "HNO.90470867.eng.abstr-s9-t2",
"arg2_id": "HNO.90470867.eng.abstr-s9-t1",
"normalized": []
}
] |
HNO.90470879.eng.abstr
|
HNO.90470879.eng.abstr
|
[
{
"id": "HNO.90470879.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Transforming growth factor-beta ( TGF- ) and interleukin 10 ( Il-10) are cytokines that have a strong immunosuppressive ability . Their secretion by tumor cells is able to suppress an immunological response against tumor . Both factors have been shown to enhance tumor growth in glioblastomas and carcinoma of the breast . We determined the expression pattern of TGF- and Il-10 in squamous cell carcinomas of the head and neck ( HNSCC ) and a possible association with tumor stage and their pre-treatment cytokine serum levels . Cytokine expression in primary tumors and metastases of 21 patients with HNSCC was investigated by immunohistochemistry . To assess the TGF-2 and Il-10 levels in tumor patients before therapy 49 serum specimens were analyzed by ELISA . TGF-2 was detected in 95% of all tumor tissues analyzed and Il-10 in 79% of all tumors . TGF-2 was localized in tumor cells and tumor borders , while Il-10 was preferentially found in peritumoral connective tissue . Metastasizing tumors showed elevated pretreatment serum levels for TGF-2 and Il-10. There was no correlation between TGF-2 and Il-10 expression in tumor tissue and pretreatment serum levels . Our data show that the majority of HNSCC analyzed express TGF-2 and Il-10. A correlation between pretherapy elevated cytokine serum levels and tumor grade was shown ."
],
"offsets": [
[
0,
1339
]
]
}
] |
[
{
"id": "HNO.90470879.eng.abstr-s1-t1",
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"growth"
],
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[
13,
19
]
],
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{
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"db_id": "C0018270"
},
{
"db_name": "UMLS",
"db_id": "C0220844"
}
]
},
{
"id": "HNO.90470879.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"interleukin"
],
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45,
56
]
],
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{
"db_name": "UMLS",
"db_id": "C0021764"
}
]
},
{
"id": "HNO.90470879.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"cytokines"
],
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73,
82
]
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{
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"db_id": "C0079189"
}
]
},
{
"id": "HNO.90470879.eng.abstr-s1-t4",
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"text": [
"immunosuppressive"
],
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[
102,
119
]
],
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{
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"db_id": "C0021081"
}
]
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] |
[] |
[] |
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] |
HNO.90470885.eng.abstr
|
HNO.90470885.eng.abstr
|
[
{
"id": "HNO.90470885.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The immunomodulating effect of primary surgical intervention was investigated in 33 patients with squamous cell carcinomas of the oral cavity , pharynx and larynx . An operation time longer than 7 h was significantly associated with a decrease in lymphocytes , CD4+ T-lymphocytes and CD8+ T-lymphocytes . The CD4/CD8-ratio as a marker for the down-regulation of the cellular immune response was slightly decreased but was still in the normal range . CD4-lymphocyte counts increased 7 days after operation while CD8 lymphocytes were found elevated 4 weeks after sugery . The in vitro stimulation of the lymphocytes was impaired for 1 to 4 weeks . Interleukins , interferon-gamma and tumor necrosis factor did not show any changes after surgery . Decreases of lymphocytes , especially CD4+ and CD8+ lymphocytes , were significantly associated with the time of operation and the volume of blood loss . Extensive trauma , age , different kinds of anesthesia and intensive care interventions were not associated with specific immunomodulating effects , although these factors might be responsible for suppressing cytokine responses ."
],
"offsets": [
[
0,
1128
]
]
}
] |
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[] |
[] |
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] |
HNO.90470899.eng.abstr
|
HNO.90470899.eng.abstr
|
[
{
"id": "HNO.90470899.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Although induction chemotherapy administered prior to local therapy produces encouraging initial response rates in head and neck cancer , randomized studies have failed to demonstrate an improvement in survival rates . All randomized studies included only patients with advanced stage III and IV disease . In our opinion , this is the main reason for the low rate of complete responses demonstrated in the randomized trials ( maximum 18% ) . Frei et al. estimate that a 40%-50% complete response rate is necessary before improved survival rates are seen . To date , such complete response rates with induction chemotherapy have only been attainable in resectable T2-T3, N0-N2 disease . Therefore , we initiated a prospective randomized trial including only patients with the mentioned disease stages . Patients ( pts ) were randomized to receive either induction chemotherapy with three cycles of carboplatin/5-FU prior to surgery and radiotherapy ( arm A , 70 pts ) or standard treatment with surgery and radiotherapy ( arm B , 74 pts ) . Patients were classified according to primary tumour site and neck disease . The observed remission rate after chemotherapy confirmed the primary estimated rate for this subgroup of patients with head and neck cancer ( CR : 43% , PR : 37% , NR : 15% , PD : 5% ) . After a follow-up of 12-96 months overall survival was 58% in arm A and 45% in arm B ( n.s. ) . Disease-free survival in arm A ( 61% ) is statistically significantly better than in arm B ( 43% , P=0.03). Therefore , we recommend further controlled trials to investigate the role of induction chemotherapy in patients with primary resectable carcinomas of the oral cavity and tonsils and stage T2-T3 and N0-N2 disease prior to surgery ."
],
"offsets": [
[
0,
1739
]
]
}
] |
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] |
[] |
[] |
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HNO.90470907.eng.abstr
|
HNO.90470907.eng.abstr
|
[
{
"id": "HNO.90470907.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Acute hearing loss following non-otologic surgery and general anesthesia is a rare occurrence . Deafness following anesthesia has more commonly been associated with spinal anesthesia or cardiopulmonary bypass surgical procedures . We present a case with unilateral cochlear dysfunction and sensorineural hearing loss after inguinal hernia operation . The literature is reviewed and the mechanisms causing hearing loss during anesthesia are discussed ."
],
"offsets": [
[
0,
451
]
]
}
] |
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{
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}
] |
[] |
[] |
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HNO.90470941.eng.abstr
|
HNO.90470941.eng.abstr
|
[
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"id": "HNO.90470941.eng.abstr-passage-0",
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"text": [
"An absolute requirement for acquiring a driving license according to German law consists in the suitability for driving a motor vehicle . The \" driving license decree \" defines these requirements ; in case of doubt the administrative authority may demand a medical certificate . According to law ( enactment : 1.1.99 ) these medical certificates must be refunded by either appropriate medical specialists , company doctors or public health officers . The criterions for appraisal are set down in the guidelines for driving ability which are edited by the advisory board for traffic medicine ; a new edition will be published soon . Concerning otorhinolaryngology hearing impairment and dizziness are the most relevant diseases . Bilateral deafness is no general exception for confering a driving license for the classes A and B ; for classes C and DE hearing loss , established from the pure tone audiogram must not exceed 60% ; an exceptional case is a three year demonstration of reliability in class B. Permanent dizziness or vertigo attacks are in most cases incompatible with confering driving licenses . The most important issue for medical appraisal is to determine the amount of compensation of the impaired sense organ . Therefore in cases of multiple disabilities more stringent criterions must be established ."
],
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]
]
}
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] |
[] |
[] |
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] |
HNO.90470947.eng.abstr
|
HNO.90470947.eng.abstr
|
[
{
"id": "HNO.90470947.eng.abstr-passage-0",
"type": "abstract",
"text": [
"In benign laryngotracheal stenosis the amount of respiratory deterioration rather than the crude morphologic appearance will determine whether or not surgical measures such as dilatation or resection should be applied . This review focusses on currently available and newly developed diagnostic tools to assess the functional importance of central airway obstruction . After an outline of upper airway physiology is formulated , spirometric measurements at rest are collected . Among these , Peak Expiratory Flow Rate ( PEF ) proved to be the simplest and most reliable parameter to monitor an obstructing lesion of the upper airways . A novel technique for fibrobronchoscopic assessment of glottic and tracheal resistance is presented in detail . In contrast to usual tests of total airflow resistance which cannot distinguish between central and peripheral contributions , this test identifies the pressure-flow-relationship created exclusively by the local lesion . In serial stenoses , it indicates which is of higher clinical impact . Patients with upper airway obstruction complain of impaired exercise capacity . They tend to hypoventilate with imminent respiratory muscle fatigue . Therefore , spiroergometry may play a role in defining the point of incomplete compensation of a central load . The decision to operate will depend upon up the degree of physical capacity required to compensate for the stenosis ."
],
"offsets": [
[
0,
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]
]
}
] |
[
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] |
[] |
[] |
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] |
HNO.90470957.eng.abstr
|
HNO.90470957.eng.abstr
|
[
{
"id": "HNO.90470957.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Abstract The 5th edition of the TNM classification entails a number of changes concerning head and neck tumors . The division of stage IV tumors into three subcategories marks a significant expansion of the stage grouping procedure . Methods : In a retrospective study the clinical course of 3247 patients with head and neck carcinomas were comparatively evaluated according to the 4th and 5th editions of the new TNM classification . In particular it was the aim of the study to test the prognostic relevance of the subdivision of stage IV especially in mucosal cancer . Results : In classifying the primary tumor the most extensive changes were noted for supraglottic and salivary gland tumors . On the basis of the 4th edition of the TNM classification the following recurrence-free 5-year survival rates for 3033 cases of mucosal cancer were calculated : stage I 91,0% , stage II 78,6% , stage III 61,4% , stage IV 31,0% . The calculations based on the 5th edition yielded : stage I 91,0% , stage II 77,2% , stage III 61,2% , stage IVA 32,4% , stage IVB 25,3% , stage IVC 3,6% . Conclusions : The adequacy of the revised stage classification in establishing a prognostic hierarchy was confirmed . However , a significant prognostic distinction between N2- ( stage IVA ) and N3-metastasis ( stage IVB ) could not be found ."
],
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0,
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]
]
}
] |
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] |
[] |
[] |
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HNO.90470963.eng.abstr
|
HNO.90470963.eng.abstr
|
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{
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],
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[
0,
268
]
]
}
] |
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72,
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] |
[] |
[] |
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HNO.90470970.eng.abstr
|
HNO.90470970.eng.abstr
|
[
{
"id": "HNO.90470970.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The programming of a cochlear implant speech processor used by young children is often difficult , especially when the stimulus level associated with maximum auditory loudness ( MAL ) needs to be determined . Excessively high stimulation should be avoided as this can have a traumatic effect . The aim of this study was to determine if a relationship exists between the intraoperatively determined electrical stapedius reflex threshold ( ESRT ) and the postoperatively determined MAL and hearing threshold for 27 patients , each having one of three implant types . The question of whether the ESRT provides a practical technique to simplify , improve and accelerate speech processor programming was investigated . For the monopolar stimulation mode used for the Med-El and Clarion implant systems , the average MAL and threshold was expressed as a percentage of the average ESRT across all electrodes . For the \" common ground \" stimulation mode used for the Nucleus implant system , a parabolic transformation was used to relate MAL and ESRT to one another . These transformations between MAL values calculated from the ESRT and the actual MAL values , determined psychoacoustically , diverged considerably from one another . Therefore , it was not possible to determine the MAL from the ESRT with certainty . The ESRT does , however , provide a means to estimate an approximate upper boundary for the MAL , apart from its use to control implant function . The determination of the exact MAL will still need to be determined using behavioural techniques ."
],
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0,
1556
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]
}
] |
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"speech"
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{
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"children"
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{
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"aim"
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{
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{
"id": "HNO.90470970.eng.abstr-s6-t1",
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}
] |
[] |
[] |
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{
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] |
HNO.90470976.eng.abstr
|
HNO.90470976.eng.abstr
|
[
{
"id": "HNO.90470976.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Mucosal lesions of the nasal septum during septal surgery are frequent , but there is scarce information in the literature about their outcome . In 283 operations of the nasal septum , 92 ( 32.5% ) mucosal lesions occurred , 67 of these could be documented and classified 1 , 3 and 6 months postoperatively . Although there was no therapy in 93% ( 74 cases ) of the one-sided lesions , no permanent septal perforation was seen . A total of 7% ( six cases ) were treated by suture or lyophilised dura combined with tissue adhesive . On the other hand , double-sided and correspondent lesions ( 12 cases : six without therapy , four sutures , one lyophilised fascia , one tissue adhesive ) showed a perforation in five cases without any symptoms . This represents 1.7% of all operations of the nasal septum and 7.4% of all recorded mucosal lesions of the nasal septum . Although the number of examinations are still few , it might be justifiable to conclude that one-sided lesions of the nasal septum need no specific therapy . All bilateral corresponding lesions , even those smaller than 5 mm , should be treated by one-sided suture in the anterior septum and with tissue adhesive in the posterior septum . The use of cartilage , bone or fascia alone is insufficient . Large defects of the mucosa should be treated by maximal therapy , i.e. covering with lyophilised fascia or dura , underlaying of cartilage or bone and using tissue adhesive ."
],
"offsets": [
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0,
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]
]
}
] |
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}
] |
[] |
[] |
[
{
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HNO.90470981.eng.abstr
|
HNO.90470981.eng.abstr
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"The authors have for the first time evaluated the basic parameters of the voice using computed voice analysis in patients with myasthenia gravis ( MG ) . The aim of the study was to introduce an objective method suitable for the assessment of dysphonic symptoms , which predominate in bulbar , oculobulbar and generalized MG . Voice profile studies included the evaluation of the singing voice range , voice dynamics , maximum phonation time , and mean fundamental frequency and intensity during speech . The characteristic of the stroboscopic picture was also determined . Investigations were carried out before and after the intake of Mestinon , a reversible cholinesterase inhibitor , and healthy subjects were used as a control group . In MG , the voice range and dynamics are badly impaired , maximum phonation time is shortened , the mean fundamental frequency during speech is increased , while the intensity is decreased . Mestinon resulted in an improvement in all these parameters , however , they were still impaired in comparison to the control subjects . Most changes were found to be statistically significant . The authors emphasize the role of the otolaryngologist and objective phoniatric methods in the evaluation of MG and other myasthenia-like neurological diseases . The use of these methods for the assessment of phoniatric symptoms in neurological diseases is highly recommended ."
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HNO.90470990.eng.abstr
|
HNO.90470990.eng.abstr
|
[
{
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"We report our experience in managing a temporal bone fracture after head trauma that had no apparent clinical signs . Recurrent CSF rhinorrhea and meningitis lead to extensive diagnostic procedures . Operative exploration of the temporal bone demonstrated a fracture line along the horizontal part of the carotid artery . The location of the fracture did not cause such typical symptoms as hearing impairment , facial paralysis , vertigo or tinnitus . Only CSF liquorrhea through the Eustachian tube indicated a fracture at the lateral skull base ."
],
"offsets": [
[
0,
548
]
]
}
] |
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{
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}
] |
[] |
[] |
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] |
HNO.90471038.eng.abstr
|
HNO.90471038.eng.abstr
|
[
{
"id": "HNO.90471038.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Although many studies are available concerning the treatment of sudden deafness using hyperbaric oxygenation , only a few of these deal with tinnitus . The aim of the present study was to evaluate the therapeutic use of hyperbaric oxygenation in cases of tinnitus . A total of 193 patients , having undergone primary intravenous hemorheologic therapy , were treated with hyperbaric oxygenation . Tinnitus was evaluated before , after ten sessions and after 15 sessions using a tinnitus questionaire . Additionally , an audiometric examination was performed . Measurable improvements of the tinnitus occurred in 22% of the patients , whereas a moderate improvement was seen in 17% of cases . 10.4% showed an excellent improvement and tinnitus disappeared completely in two patients . The improvement rate decreased in those cases where the time from onset of tinnitus exceeded 40 days . In conclusion , hyperbaric oxygenation seems to be a moderately effective additional treatment in the therapy of tinnitus after primary hemorheologic therapy , provided the time from onset of tinnitus is less than 1 month ."
],
"offsets": [
[
0,
1109
]
]
}
] |
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}
] |
[] |
[] |
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HNO.90471046.eng.abstr
|
HNO.90471046.eng.abstr
|
[
{
"id": "HNO.90471046.eng.abstr-passage-0",
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"From April 1992 to July 1998 stereotactic radiosurgery ( Gamma Knife ) was used to treat 1382 patients ; 181 had acoustic neurinomas and were followed up , 44 of them for at least 4 years ( 48-75 months , median 60 ) . With no mortality control of growth tumor was achieved in all cases but one . It was possible to preserve useful hearing in more than half of the patients ( 60% ) . In two patients complications due to the radiation with enlargement of the cystic component were observed . One patient needed additional microsurgical decompression . Three patients suffered transient incomplete facial palsy ( one permanent , HBI III ) , and two patients complained of mild trigeminal neuropathy . One suffered from hydrocephalus and a shunting procedure was necessary . The neurological state improved in 23 patients ( 52% ) ; five complained of new or worsened deficits . Radiosurgery is an effective alternative treatment for acoustic neurinomas with exceptionally low mortality and morbidity . With respect to preserving cranial nerve function the results are just as good as those of microsurgical resection . Short duration of hospitalization and quick return to normal activities make radiosurgery quite cost effective ."
],
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}
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[] |
[] |
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] |
HNO.90471052.eng.abstr
|
HNO.90471052.eng.abstr
|
[
{
"id": "HNO.90471052.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The vertical open MRI ( Signa SP , 0,5Tesla ) is ideal for interventional diagnosis and therapy . From our point of view indications in Otorhinolaryngology are biopsies of tumors which are difficult to access such as the petrous apex and the petroclival region , the parapharyngeal space and neck and the orbit . Furthermore the open MRI is useful in the surgery of paranasal sinuses , in the evaluation of tissue-resection and helpfull in detection of the anatomy of delicate structures as the internal carotid artery , the skull-base and the orbit . Also navigation in open MRI is possible for example with a flash-point-system . The advantage to conventional navigation systems is the possibility of real-time-imaging , which allows detection of tissue shift occuring during the procedure . We report about our experience with ten biopsies of the petrous apex and the petroclival junction and two biopsy of the parapharyngeal space and the neck . Further experience was gained with MR guided placement of afterloading tubes into large neck metastases in three cases and microscopic surgery of paranasal sinuses in five cases . In all operative procedures an excellent resolution was found especially for soft tissue structures as for example blood vessels . With the aid of special pointer systems or artefacts by surgical instruments all relevant anatomical structures could be detected intraoperatively , concerning normal and pathologic tissue . Thus open MRI proved to be a helpful instrument in these operative procedures ."
],
"offsets": [
[
0,
1531
]
]
}
] |
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],
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],
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]
},
{
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{
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},
{
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},
{
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],
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},
{
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},
{
"id": "HNO.90471052.eng.abstr-s3-t2",
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},
{
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],
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] |
[] |
[] |
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] |
HNO.90471058.eng.abstr
|
HNO.90471058.eng.abstr
|
[
{
"id": "HNO.90471058.eng.abstr-passage-0",
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"Purpose : It is well known that chemotherapy and radiotherapy in other tumor sites than head and neck cause immunomodulating effects . The purpose of this trial was to assess the influence of radiochemotherapy in head and neck on cellular and subcellular immunity ."
],
"offsets": [
[
0,
265
]
]
}
] |
[
{
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],
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44
]
],
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{
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}
]
},
{
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92
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},
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217
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},
{
"id": "HNO.90471058.eng.abstr-s2-t3",
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255,
263
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0020964"
}
]
}
] |
[] |
[] |
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HNO.90471063.eng.abstr
|
HNO.90471063.eng.abstr
|
[
{
"id": "HNO.90471063.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Hyperimmunoglobulin E syndrome ( Hiob syndrome or Buckley syndrome ) is a rare disorder of the immune system that can show characteristic manifestations in the head and neck . Typical symptoms are fever , recurrent urticarial rashes , lymphadenitis , and bacterial infections of the skin and various parenchymatous organs . Diagnosis is established by elevated serum IgE concentrations with the absence of any signs of allergy or parasitic disease . We present our clinical experiences in managing of a 29-year old woman whose hyper IgE syndrome was diagnosed initially during of the treatment of lymphatic hyperplasia of the base of the tongue although she had typical symptoms of hyper IgE syndrome for some years . High-dose intravenous immunoglobulin therapy ( IVIG ) was found to be well-tolerated and effective . More than one year after a single course of immunoglobin therapy symptoms markedly improved . Current knowledge and therapeutic options in hyper IgE syndrome are discussed . We recommend that IVIG be considered as one of the first choices in the treatment of hyper IgE syndrome ."
],
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0,
1098
]
]
}
] |
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}
] |
[] |
[] |
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] |
Herz.00250068.eng.abstr
|
Herz.00250068.eng.abstr
|
[
{
"id": "Herz.00250068.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The obligate intracellular bacterium Chlamydia pneumoniae has been implicated in the pathogenesis of atherosclerosis since viable pathogen has been recovered from plaques . Chlamydiae are epithelial pathogens notorious for causing persistent infection . Atherosclerosis , however , is a chronic inflammatory disease involving mesenchymal cells of the vascular wall . A bacterial contribution to atherosclerosis appears more relevant if the resident mesenchymal cells of the vascular wall that constitute the plaque can support chlamydial infection continuously ."
],
"offsets": [
[
0,
562
]
]
}
] |
[
{
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],
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36
]
],
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},
{
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]
},
{
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},
{
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],
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{
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{
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]
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]
},
{
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],
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},
{
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{
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},
{
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],
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},
{
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],
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]
},
{
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],
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{
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}
]
}
] |
[] |
[] |
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] |
Herz.00250073.eng.abstr
|
Herz.00250073.eng.abstr
|
[
{
"id": "Herz.00250073.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Aim of this study was to isolate T lymphocytes from atheromatous plaques and to determine they respond to Chlamydia antigens ."
],
"offsets": [
[
0,
126
]
]
}
] |
[
{
"id": "Herz.00250073.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"lymphocytes"
],
"offsets": [
[
35,
46
]
],
"normalized": [
{
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"db_id": "C0024264"
}
]
},
{
"id": "Herz.00250073.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"plaques"
],
"offsets": [
[
65,
72
]
],
"normalized": [
{
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},
{
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}
]
},
{
"id": "Herz.00250073.eng.abstr-s1-t3",
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"text": [
"Chlamydia"
],
"offsets": [
[
106,
115
]
],
"normalized": [
{
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{
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}
]
},
{
"id": "Herz.00250073.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
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],
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[
116,
124
]
],
"normalized": [
{
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},
{
"id": "Herz.00250073.eng.abstr-s1-t5",
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],
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[
33,
46
]
],
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]
},
{
"id": "Herz.00250073.eng.abstr-s1-t6",
"type": "umlsterm",
"text": [
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],
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[
52,
72
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0004150"
}
]
}
] |
[] |
[] |
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] |
Herz.00250079.eng.abstr
|
Herz.00250079.eng.abstr
|
[
{
"id": "Herz.00250079.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Appreciation of atherosclerosis as an infectious disease has fostered interest in the role that Chlamydia pneumoniae may play in atheroma development . Although data from seroepidemiological and experimental studies have established an association between the pathogen and atherosclerosis , little is known about how the organism contributes to lesion development . Atherosclerosis is a complex disease process and the role of any pathogen must be considered in the context of other risk factors ."
],
"offsets": [
[
0,
497
]
]
}
] |
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],
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},
{
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}
] |
[] |
[] |
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}
] |
Herz.00250091.eng.abstr
|
Herz.00250091.eng.abstr
|
[
{
"id": "Herz.00250091.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Infectious agents may directly or indirectly ( through the response of the host's immune system ) modulate the growth of vascular cells . Local and/or systemic increase of cytokines could influence the extent of ( re- ) stenosis in the vascular tree . Further studies in this field may identify patients at a high risk for atherogenesis and restenosis . Their results should be helpful in treating restenosis after percutaneous coronary interventions ."
],
"offsets": [
[
0,
452
]
]
}
] |
[
{
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],
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}
]
},
{
"id": "Herz.00250091.eng.abstr-s1-t2",
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]
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},
{
"id": "Herz.00250091.eng.abstr-s1-t3",
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],
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[
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]
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}
]
},
{
"id": "Herz.00250091.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
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] |
[] |
[] |
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] |
Herz.00250095.eng.abstr
|
Herz.00250095.eng.abstr
|
[
{
"id": "Herz.00250095.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Although transplant vasculopathy and native atherosclerosis are clinically and pathologically different entities , the pathogenesis of both diseases exhibits some common mechanisms . Both may be regarded as responses to injury within a broadened concept of the immune system . Alloantigens ( e . g . on donor endothelial cells ) or autoantigens ( e . g . oxydized LDL cholesterol ) are presented by antigen presenting cells to the T cells of the body's immune system . With the appropriate costimulatory signal , this signal pattern generates a differentiated T cell , B cell , and inflammatory cell response whereas without the second signal , the immune cells undergo apoptosis . In case of immune cell proliferation and differentiation , a coordinated pattern of cytokine release is initiated . Monocyte-derived macrophages are also involved in this process which culminates in rolling , sticking , and idapedesis through the coronary vascular endothelium and phenotype switch of medial smooth muscle cells mediated by generation off growth-promoting cytokines . Thus , viewed within a broadened paradigm of the immune system's role both disease entities may represent different vignettes of an integrated pathophysiological response to an endothelial injury ."
],
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[
0,
1263
]
]
}
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] |
[] |
[] |
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Herz.00250100.eng.abstr
|
Herz.00250100.eng.abstr
|
[
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],
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]
]
}
] |
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] |
Herz.00250108.eng.abstr
|
Herz.00250108.eng.abstr
|
[
{
"id": "Herz.00250108.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The presence of inflammatory infiltrates in unstable coronary plaques suggests that inflammatory processes may contribute to the pathogenesis of these syndromes . In patients with unstable angina , coronary atherosclerotic plaques are characterized by the presence of macrophages , and to a lesser extent , T-lymphocytes , at the immediate site of either plaque rupture or superficial erosion : moreover , the rupture-related inflammatory cells are activated , indicating ongoing inflammation at the site of plaque disruption . These observations are confirmed by clinical studies demonstrating activated circulating neutrophils , lymphocytes and monocytes , and increased concentrations of pro-inflammatory cytokines , such as interleukin ( IL ) 1 and 6 , and of acute phase reactants in patients with unstable angina and myocardial infarction . In particular elevated levels of C-reactive protein are associated with an increased risk of in-hospital and 1 to 2 years new coronary events in patients with unstable angina , but are also associated with an increased long-term risk of death and myocardial infarction in apparently normal subjects . Thus , accumulating evidence suggests that inflammation may cause local endothelial activation and , possibly , plaque fissure , leading to unstable angina and infarction . Although no information is yet available on the causes of inflammation and on its localization , these novel lines of research may open the way to a different approach to the patient with acute coronary syndromes ."
],
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0,
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}
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] |
Herz.00250113.eng.abstr
|
Herz.00250113.eng.abstr
|
[
{
"id": "Herz.00250113.eng.abstr-passage-0",
"type": "abstract",
"text": [
"In recent years we identified numerous cardiovascular risk factors and had been able to reduce cardiovascular events by a variety of different interventions . There is no question that we can improve the course of coronary artery disease ( CAD ) in patients with a high-risk profile by modifying these factors . Despite this knowledge , many patients with known CAD or myocardial infarction are not treated for secondary prevention as recommended by well established guidelines . In order to improve secondary prevention in our patients we started a project , the so called \" Marburg CAD Prevention Project \" . By this we combine our computer data base of the CAD preventional routine laboratory with the computer program CARDDAS . Individual risk factors and the angiographic findings were analyzed . Patients as well as local physicians were informed on the need to treat the important risk factors . This approach ensures that at least all of out patients with documented CAD receive the appropriate preventional recommendations and treatment ."
],
"offsets": [
[
0,
1047
]
]
}
] |
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] |
[] |
[] |
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}
] |
Herz.00250117.eng.abstr
|
Herz.00250117.eng.abstr
|
[
{
"id": "Herz.00250117.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Atherosclerosis has many features of a chronic inflammatory disease . Atherosclerotic lesions contain inflammatory cells like activated T-lymphocytes and macrophages . Systemic markers of inflammation such as white blood cells , C-reactive protein , serum amyloid A , interleukin 6 and soluble adhesion molecules are predictive of future cardiovascular events , even after adjustment for the contribution of established cardiovascular risk factors . Atherogenic lipoprotein particles , in particular modified low-density lipoproteins ( LDL ) , elicit pro-inflammatory responses of cellular elements of the vessel wall , including endothelial dysfunction and activation of monocyte-derived macrophages ."
],
"offsets": [
[
0,
702
]
]
}
] |
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]
}
] |
[] |
[] |
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] |
Herz.00250126.eng.abstr
|
Herz.00250126.eng.abstr
|
[
{
"id": "Herz.00250126.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Vascular endothelial growth factor ( VEGF ) was discovered 10 years ago as a growth factor that can regulate angiogenesis and in addition the permeability of blood vessels . Numerous studies have revealed that it is essential for normal embryonic development and that it plays a major role in physiological and pathological events of angiogenesis in adults . It is unique in that its expression is regulated directly by hypoxia . These properties are now being exploited in attempts aimed at the induction of new blood vessels in pathological situations such as ischemic heart disease . Five VEGF forms of 121 to 206 amino-acids are produced from a single gene by alternative splicing . Cells expressing VEGF usually express several forms simultaneously . VEGF121 does not contain exons 6 and 7 of the gene and consequently lacks a heparin binding ability . However , this form is fully active as an inducer of angiogenesis , and as a blood vessel permeabilizing agent . Exon 6 and 7 contain 2 independent heparin binding domains . The VEGF form containing exon 7 ( VEGF165) and the vascular endothelial growth factor form containing exon 6 ( VEGF145) display similar biological potencies raising the question of why so many VEGF forms are required . It was found that VEGF121 diffuses better because it does not bind to heparan-sulfate proteoglycans . In contrast , VEGF145 binds to extracellular matrix ad is released from it slowly . When the receptor binding properties of VEGF121 and VEGF165 were compared it was found that VEGF165 binds to a class of VEGF receptors that is not recognized by VEGF121. These receptors are encoded by the neuropilin-1 gene , and we have recently found that the related neuropilin-2 gene also encodes a VEGF165 receptor . We have recently found evidence indicating the neuropilins form complexes with another VEGF receptor , VEGFR-1. However , the biological function of this complex remains to be elucidated ."
],
"offsets": [
[
0,
1946
]
]
}
] |
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] |
Herz.00250130.eng.abstr
|
Herz.00250130.eng.abstr
|
[
{
"id": "Herz.00250130.eng.abstr-passage-0",
"type": "abstract",
"text": [
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],
"offsets": [
[
0,
183
]
]
}
] |
[
{
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],
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0,
9
]
],
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{
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}
]
},
{
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"vasodilator"
],
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[
74,
85
]
],
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]
},
{
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],
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86,
91
]
],
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},
{
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],
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164,
175
]
],
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]
},
{
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},
{
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],
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0,
17
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],
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},
{
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],
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74,
91
]
],
"normalized": [
{
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}
]
}
] |
[] |
[] |
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] |
Herz.00250156.eng.abstr
|
Herz.00250156.eng.abstr
|
[
{
"id": "Herz.00250156.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Familial dilated cardiomyopathy ( DCM ) should be an \" evidence-based \" diagnosis derived from clinical and echocardiographic screening of informed and consenting relatives of index patients , and on the examination of clinical reports for deceased relatives . Most familial dilated cardiomyopathy pedigrees show an autosomal pattern of inheritance . Very few of them are X-linked and matrilinear . Autosomal recessive inheritance is difficult to be assessed in an evidence-based setting . By linkage analysis , several loci , but no disease gene , have been identified . At present , few cases of familial dilated cardiomyopathy can benefit of a molecular diagnosis ."
],
"offsets": [
[
0,
668
]
]
}
] |
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{
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{
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"relatives"
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"index"
],
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[
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"patients"
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182,
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{
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},
{
"id": "Herz.00250156.eng.abstr-s2-t2",
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298,
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],
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},
{
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{
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},
{
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{
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{
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{
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{
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{
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}
] |
[] |
[] |
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"type": "location_of",
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"normalized": []
},
{
"id": "Herz.00250156.eng.abstr-s5-r5-t2.1-t1.1",
"type": "result_of",
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"arg2_id": "Herz.00250156.eng.abstr-s6-t1",
"normalized": []
},
{
"id": "Herz.00250156.eng.abstr-s5-r6-t2.1-t1.1",
"type": "assesses_effect_of",
"arg1_id": "Herz.00250156.eng.abstr-s6-t2",
"arg2_id": "Herz.00250156.eng.abstr-s6-t1",
"normalized": []
},
{
"id": "Herz.00250156.eng.abstr-s6-r1-t2.1-t1.1",
"type": "associated_with",
"arg1_id": "Herz.00250156.eng.abstr-s6-t2",
"arg2_id": "Herz.00250156.eng.abstr-s6-t1",
"normalized": []
},
{
"id": "Herz.00250156.eng.abstr-s6-r4-t1.1-t2.1",
"type": "associated_with",
"arg1_id": "Herz.00250156.eng.abstr-s6-t1",
"arg2_id": "Herz.00250156.eng.abstr-s6-t2",
"normalized": []
}
] |
Herz.00250176.eng.abstr
|
Herz.00250176.eng.abstr
|
[
{
"id": "Herz.00250176.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The adenine nucleotide translocator ( ANT ) , the only mitochondrial carrier for ADP and ATP , combines mitochondrial energy-producing and cytosolic energy-consuming processes . The ANT function was observed to be impaired in explanted heart tissue from patients with dilated cardiomyopathy ( DCM ) . In order to clariry whether an altered ANT isoform composition might be responsible for the restricted ANT function , we analyzed the ANT isoform expression pattern in the myocardium of patients suffering from dilated cardiomyopathy ."
],
"offsets": [
[
0,
535
]
]
}
] |
[
{
"id": "Herz.00250176.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"adenine"
],
"offsets": [
[
4,
11
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0001407"
}
]
},
{
"id": "Herz.00250176.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"nucleotide"
],
"offsets": [
[
12,
22
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0028630"
}
]
},
{
"id": "Herz.00250176.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"ANT"
],
"offsets": [
[
38,
41
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0003455"
}
]
},
{
"id": "Herz.00250176.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"carrier"
],
"offsets": [
[
69,
76
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0007293"
},
{
"db_name": "UMLS",
"db_id": "C0007294"
}
]
},
{
"id": "Herz.00250176.eng.abstr-s1-t5",
"type": "umlsterm",
"text": [
"ADP"
],
"offsets": [
[
81,
84
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0004374"
},
{
"db_name": "UMLS",
"db_id": "C0001459"
}
]
},
{
"id": "Herz.00250176.eng.abstr-s1-t6",
"type": "umlsterm",
"text": [
"ATP"
],
"offsets": [
[
89,
92
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0004482"
},
{
"db_name": "UMLS",
"db_id": "C0001480"
}
]
},
{
"id": "Herz.00250176.eng.abstr-s1-t7",
"type": "umlsterm",
"text": [
"adenine nucleotide"
],
"offsets": [
[
4,
22
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0001413"
}
]
},
{
"id": "Herz.00250176.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"ANT"
],
"offsets": [
[
182,
185
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0003455"
}
]
},
{
"id": "Herz.00250176.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"function"
],
"offsets": [
[
186,
194
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0031843"
}
]
},
{
"id": "Herz.00250176.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"heart"
],
"offsets": [
[
236,
241
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0018787"
}
]
},
{
"id": "Herz.00250176.eng.abstr-s2-t4",
"type": "umlsterm",
"text": [
"tissue"
],
"offsets": [
[
242,
248
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0040300"
}
]
},
{
"id": "Herz.00250176.eng.abstr-s2-t5",
"type": "umlsterm",
"text": [
"patients"
],
"offsets": [
[
254,
262
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0030705"
}
]
},
{
"id": "Herz.00250176.eng.abstr-s2-t6",
"type": "umlsterm",
"text": [
"cardiomyopathy"
],
"offsets": [
[
276,
290
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0027049"
}
]
},
{
"id": "Herz.00250176.eng.abstr-s2-t7",
"type": "umlsterm",
"text": [
"dilated cardiomyopathy"
],
"offsets": [
[
268,
290
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0007193"
}
]
},
{
"id": "Herz.00250176.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"ANT"
],
"offsets": [
[
340,
343
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0003455"
}
]
},
{
"id": "Herz.00250176.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"isoform"
],
"offsets": [
[
344,
351
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0597298"
}
]
},
{
"id": "Herz.00250176.eng.abstr-s3-t3",
"type": "umlsterm",
"text": [
"ANT"
],
"offsets": [
[
404,
407
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0003455"
}
]
},
{
"id": "Herz.00250176.eng.abstr-s3-t4",
"type": "umlsterm",
"text": [
"function"
],
"offsets": [
[
408,
416
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0031843"
}
]
},
{
"id": "Herz.00250176.eng.abstr-s3-t5",
"type": "umlsterm",
"text": [
"ANT"
],
"offsets": [
[
435,
438
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0003455"
}
]
},
{
"id": "Herz.00250176.eng.abstr-s3-t6",
"type": "umlsterm",
"text": [
"isoform"
],
"offsets": [
[
439,
446
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0597298"
}
]
},
{
"id": "Herz.00250176.eng.abstr-s3-t7",
"type": "umlsterm",
"text": [
"myocardium"
],
"offsets": [
[
473,
483
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0027061"
}
]
},
{
"id": "Herz.00250176.eng.abstr-s3-t8",
"type": "umlsterm",
"text": [
"patients"
],
"offsets": [
[
487,
495
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0030705"
}
]
},
{
"id": "Herz.00250176.eng.abstr-s3-t9",
"type": "umlsterm",
"text": [
"cardiomyopathy"
],
"offsets": [
[
519,
533
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0027049"
}
]
},
{
"id": "Herz.00250176.eng.abstr-s3-t10",
"type": "umlsterm",
"text": [
"dilated cardiomyopathy"
],
"offsets": [
[
511,
533
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0007193"
}
]
}
] |
[] |
[] |
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{
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{
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] |
Herz.00250181.eng.abstr
|
Herz.00250181.eng.abstr
|
[
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"id": "Herz.00250181.eng.abstr-passage-0",
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],
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[
0,
197
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]
}
] |
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] |
[] |
[] |
[] |
Herz.00250189.eng.abstr
|
Herz.00250189.eng.abstr
|
[
{
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],
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0,
733
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Herz.00250200.eng.abstr
|
Herz.00250200.eng.abstr
|
[
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],
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0,
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]
}
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{
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}
]
}
] |
[] |
[] |
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}
] |
Herz.00250210.eng.abstr
|
Herz.00250210.eng.abstr
|
[
{
"id": "Herz.00250210.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Arrhythmogenic right ventricular cardiomyopathy is a primary heart muscle disease characterized by progressive myocardial atrophy of the right ventricle , with transmural fatty or fibrofatty replacement , either segmental or diffuse , accounting for electrical instability at risk of life-threatening ventricular arrhythmias . It was recently included among cardiomyopathies in the revised WHO classification . The disease was found to be a major cause of sudden death in the young and in athletes of the Veneto Region , Italy . A familial occurrence with autosomic dominant inheritance was then discovered with a prevalence estimated to be 6/10 , 000 inhabitants and 5 loci have been identified by linkage analysis so far , 2 mapping to chromosome 14 and to chromosome 1 , 2 and 3 one each . A recessive form associated with palmoplantar keratosis has also been reported , mapping to chromosome 17. Nonetheless , the specific gene defects as well as the defective coded proteins have not yet been identified ."
],
"offsets": [
[
0,
1010
]
]
}
] |
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}
] |
Herz.00250216.eng.abstr
|
Herz.00250216.eng.abstr
|
[
{
"id": "Herz.00250216.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Enteroviruses of the Picornaviridae and primarily coxsackieviruses of group B ( CVB ) can be detected in humans and various experimental murine models of acute myocarditis and chronic heart muscle diseases indicating enterovirus persistence in the myocardium . Persistent myocardial infection is characterized by restricted viral replication and gene expression in myocytes capable of sustaining chronic inflammation . Viral cytotoxicity was found to be crucial for organ pathology both during acute and persistent infection ."
],
"offsets": [
[
0,
526
]
]
}
] |
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{
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{
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{
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{
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{
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{
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{
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{
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{
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{
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{
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{
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}
] |
[] |
[] |
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Herz.00250221.eng.abstr
|
Herz.00250221.eng.abstr
|
[
{
"id": "Herz.00250221.eng.abstr-passage-0",
"type": "abstract",
"text": [
"In the report of the 1995 World Health Federation/International Society and Federation of Cardiology ( WHF/ISFC ) Task Force on the Definition and Classification of Cardiomyopathies , the definition of heart muscle diseases was updated . Idiopathic , autoimmune , and infectious forms of inflammatory cardiomyopathy are now recognized in this definition . Enteroviruses , adenoviruses and cytomegaloviruses are considered as main etiopathological factors in the pathogenesis of inflammatory heart disease ."
],
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[
0,
506
]
]
}
] |
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[] |
[] |
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"id": "Herz.00250221.eng.abstr-s3-r2-t4.1-t2.2",
"type": "location_of",
"arg1_id": "Herz.00250221.eng.abstr-s3-t4",
"arg2_id": "Herz.00250221.eng.abstr-s3-t2",
"normalized": []
},
{
"id": "Herz.00250221.eng.abstr-s3-r3-t1.1-t2.2",
"type": "causes",
"arg1_id": "Herz.00250221.eng.abstr-s3-t1",
"arg2_id": "Herz.00250221.eng.abstr-s3-t2",
"normalized": []
},
{
"id": "Herz.00250221.eng.abstr-s3-r5-t3.1-t2.2",
"type": "causes",
"arg1_id": "Herz.00250221.eng.abstr-s3-t3",
"arg2_id": "Herz.00250221.eng.abstr-s3-t2",
"normalized": []
},
{
"id": "Herz.00250221.eng.abstr-s3-r6-t4.1-t7.1",
"type": "location_of",
"arg1_id": "Herz.00250221.eng.abstr-s3-t4",
"arg2_id": "Herz.00250221.eng.abstr-s3-t7",
"normalized": []
},
{
"id": "Herz.00250221.eng.abstr-s3-r7-t6.1-t3.1",
"type": "affects",
"arg1_id": "Herz.00250221.eng.abstr-s3-t6",
"arg2_id": "Herz.00250221.eng.abstr-s3-t3",
"normalized": []
},
{
"id": "Herz.00250221.eng.abstr-s3-r8-t4.1-t6.1",
"type": "location_of",
"arg1_id": "Herz.00250221.eng.abstr-s3-t4",
"arg2_id": "Herz.00250221.eng.abstr-s3-t6",
"normalized": []
},
{
"id": "Herz.00250221.eng.abstr-s3-r9-t7.1-t3.1",
"type": "affects",
"arg1_id": "Herz.00250221.eng.abstr-s3-t7",
"arg2_id": "Herz.00250221.eng.abstr-s3-t3",
"normalized": []
},
{
"id": "Herz.00250221.eng.abstr-s3-r10-t6.1-t2.1",
"type": "affects",
"arg1_id": "Herz.00250221.eng.abstr-s3-t6",
"arg2_id": "Herz.00250221.eng.abstr-s3-t2",
"normalized": []
},
{
"id": "Herz.00250221.eng.abstr-s3-r11-t7.1-t2.1",
"type": "affects",
"arg1_id": "Herz.00250221.eng.abstr-s3-t7",
"arg2_id": "Herz.00250221.eng.abstr-s3-t2",
"normalized": []
},
{
"id": "Herz.00250221.eng.abstr-s3-r12-t1.1-t6.1",
"type": "causes",
"arg1_id": "Herz.00250221.eng.abstr-s3-t1",
"arg2_id": "Herz.00250221.eng.abstr-s3-t6",
"normalized": []
},
{
"id": "Herz.00250221.eng.abstr-s3-r13-t4.1-t3.1",
"type": "location_of",
"arg1_id": "Herz.00250221.eng.abstr-s3-t4",
"arg2_id": "Herz.00250221.eng.abstr-s3-t3",
"normalized": []
},
{
"id": "Herz.00250221.eng.abstr-s3-r14-t6.1-t1.1",
"type": "affects",
"arg1_id": "Herz.00250221.eng.abstr-s3-t6",
"arg2_id": "Herz.00250221.eng.abstr-s3-t1",
"normalized": []
},
{
"id": "Herz.00250221.eng.abstr-s3-r15-t2.1-t6.1",
"type": "causes",
"arg1_id": "Herz.00250221.eng.abstr-s3-t2",
"arg2_id": "Herz.00250221.eng.abstr-s3-t6",
"normalized": []
},
{
"id": "Herz.00250221.eng.abstr-s3-r16-t2.2-t3.1",
"type": "affects",
"arg1_id": "Herz.00250221.eng.abstr-s3-t2",
"arg2_id": "Herz.00250221.eng.abstr-s3-t3",
"normalized": []
},
{
"id": "Herz.00250221.eng.abstr-s3-r17-t3.1-t6.1",
"type": "causes",
"arg1_id": "Herz.00250221.eng.abstr-s3-t3",
"arg2_id": "Herz.00250221.eng.abstr-s3-t6",
"normalized": []
},
{
"id": "Herz.00250221.eng.abstr-s3-r18-t7.1-t1.1",
"type": "affects",
"arg1_id": "Herz.00250221.eng.abstr-s3-t7",
"arg2_id": "Herz.00250221.eng.abstr-s3-t1",
"normalized": []
},
{
"id": "Herz.00250221.eng.abstr-s3-r19-t4.1-t2.1",
"type": "location_of",
"arg1_id": "Herz.00250221.eng.abstr-s3-t4",
"arg2_id": "Herz.00250221.eng.abstr-s3-t2",
"normalized": []
},
{
"id": "Herz.00250221.eng.abstr-s3-r20-t4.1-t1.1",
"type": "location_of",
"arg1_id": "Herz.00250221.eng.abstr-s3-t4",
"arg2_id": "Herz.00250221.eng.abstr-s3-t1",
"normalized": []
},
{
"id": "Herz.00250221.eng.abstr-s3-r22-t1.1-t7.1",
"type": "causes",
"arg1_id": "Herz.00250221.eng.abstr-s3-t1",
"arg2_id": "Herz.00250221.eng.abstr-s3-t7",
"normalized": []
},
{
"id": "Herz.00250221.eng.abstr-s3-r23-t2.2-t1.1",
"type": "affects",
"arg1_id": "Herz.00250221.eng.abstr-s3-t2",
"arg2_id": "Herz.00250221.eng.abstr-s3-t1",
"normalized": []
},
{
"id": "Herz.00250221.eng.abstr-s3-r24-t2.1-t7.1",
"type": "causes",
"arg1_id": "Herz.00250221.eng.abstr-s3-t2",
"arg2_id": "Herz.00250221.eng.abstr-s3-t7",
"normalized": []
}
] |
Herz.00250227.eng.abstr
|
Herz.00250227.eng.abstr
|
[
{
"id": "Herz.00250227.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Genetic deficiency of the dystrophin-glycoprotein complex causes hereditary dilated cardiomyopathy . Enteroviruses can also cause cardiomyopathy and we have recently described a potential molecular mechanism for enterovirus-induced dilated cardiomyopathy . The coxsackieviral protease 2A proteolytically cleaves and functionally impairs dystrophin . Additionally , during infection with coxsackievirus B3, the dystrophin-glycoprotein complex becomes disrupted and the sarcolemmal integrity is lost ."
],
"offsets": [
[
0,
499
]
]
}
] |
[
{
"id": "Herz.00250227.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"deficiency"
],
"offsets": [
[
8,
18
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0011155"
}
]
},
{
"id": "Herz.00250227.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"dystrophin-glycoprotein"
],
"offsets": [
[
26,
49
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0079259"
}
]
},
{
"id": "Herz.00250227.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"dystrophin-glycoprotein"
],
"offsets": [
[
26,
49
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0017968"
}
]
},
{
"id": "Herz.00250227.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"cardiomyopathy"
],
"offsets": [
[
84,
98
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0027049"
}
]
},
{
"id": "Herz.00250227.eng.abstr-s1-t5",
"type": "umlsterm",
"text": [
"dilated cardiomyopathy"
],
"offsets": [
[
76,
98
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0007193"
}
]
},
{
"id": "Herz.00250227.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"Enteroviruses"
],
"offsets": [
[
101,
114
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0014383"
}
]
},
{
"id": "Herz.00250227.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"cardiomyopathy"
],
"offsets": [
[
130,
144
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0027049"
}
]
},
{
"id": "Herz.00250227.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"cardiomyopathy"
],
"offsets": [
[
240,
254
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0027049"
}
]
},
{
"id": "Herz.00250227.eng.abstr-s2-t4",
"type": "umlsterm",
"text": [
"dilated cardiomyopathy"
],
"offsets": [
[
232,
254
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0007193"
}
]
},
{
"id": "Herz.00250227.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"protease"
],
"offsets": [
[
276,
284
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0030946"
}
]
},
{
"id": "Herz.00250227.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"dystrophin"
],
"offsets": [
[
337,
347
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0079259"
}
]
},
{
"id": "Herz.00250227.eng.abstr-s4-t1",
"type": "umlsterm",
"text": [
"infection"
],
"offsets": [
[
372,
381
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0021311"
}
]
},
{
"id": "Herz.00250227.eng.abstr-s4-t2",
"type": "umlsterm",
"text": [
"dystrophin-glycoprotein"
],
"offsets": [
[
410,
433
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0079259"
}
]
},
{
"id": "Herz.00250227.eng.abstr-s4-t3",
"type": "umlsterm",
"text": [
"dystrophin-glycoprotein"
],
"offsets": [
[
410,
433
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0017968"
}
]
}
] |
[] |
[] |
[
{
"id": "Herz.00250227.eng.abstr-s1-r1-t3.1-t1.1",
"type": "interacts_with",
"arg1_id": "Herz.00250227.eng.abstr-s4-t3",
"arg2_id": "Herz.00250227.eng.abstr-s4-t1",
"normalized": []
},
{
"id": "Herz.00250227.eng.abstr-s1-r2-t3.1-t5.1",
"type": "affects",
"arg1_id": "Herz.00250227.eng.abstr-s4-t3",
"arg2_id": "Herz.00250227.eng.abstr-s1-t5",
"normalized": []
},
{
"id": "Herz.00250227.eng.abstr-s1-r3-t4.1-t1.1",
"type": "produces",
"arg1_id": "Herz.00250227.eng.abstr-s2-t4",
"arg2_id": "Herz.00250227.eng.abstr-s4-t1",
"normalized": []
},
{
"id": "Herz.00250227.eng.abstr-s1-r4-t1.1-t5.1",
"type": "affects",
"arg1_id": "Herz.00250227.eng.abstr-s4-t1",
"arg2_id": "Herz.00250227.eng.abstr-s1-t5",
"normalized": []
},
{
"id": "Herz.00250227.eng.abstr-s1-r5-t3.1-t4.1",
"type": "affects",
"arg1_id": "Herz.00250227.eng.abstr-s4-t3",
"arg2_id": "Herz.00250227.eng.abstr-s2-t4",
"normalized": []
},
{
"id": "Herz.00250227.eng.abstr-s1-r6-t1.1-t4.1",
"type": "affects",
"arg1_id": "Herz.00250227.eng.abstr-s4-t1",
"arg2_id": "Herz.00250227.eng.abstr-s2-t4",
"normalized": []
},
{
"id": "Herz.00250227.eng.abstr-s1-r7-t5.1-t1.1",
"type": "produces",
"arg1_id": "Herz.00250227.eng.abstr-s1-t5",
"arg2_id": "Herz.00250227.eng.abstr-s4-t1",
"normalized": []
},
{
"id": "Herz.00250227.eng.abstr-s1-r8-t1.1-t3.1",
"type": "interacts_with",
"arg1_id": "Herz.00250227.eng.abstr-s4-t1",
"arg2_id": "Herz.00250227.eng.abstr-s4-t3",
"normalized": []
},
{
"id": "Herz.00250227.eng.abstr-s2-r1-t1.1-t3.1",
"type": "causes",
"arg1_id": "Herz.00250227.eng.abstr-s4-t1",
"arg2_id": "Herz.00250227.eng.abstr-s4-t3",
"normalized": []
},
{
"id": "Herz.00250227.eng.abstr-s2-r2-t3.1-t1.1",
"type": "affects",
"arg1_id": "Herz.00250227.eng.abstr-s4-t3",
"arg2_id": "Herz.00250227.eng.abstr-s4-t1",
"normalized": []
},
{
"id": "Herz.00250227.eng.abstr-s2-r3-t1.1-t2.1",
"type": "causes",
"arg1_id": "Herz.00250227.eng.abstr-s4-t1",
"arg2_id": "Herz.00250227.eng.abstr-s4-t2",
"normalized": []
},
{
"id": "Herz.00250227.eng.abstr-s2-r4-t4.1-t1.1",
"type": "affects",
"arg1_id": "Herz.00250227.eng.abstr-s2-t4",
"arg2_id": "Herz.00250227.eng.abstr-s4-t1",
"normalized": []
},
{
"id": "Herz.00250227.eng.abstr-s2-r5-t1.1-t4.1",
"type": "causes",
"arg1_id": "Herz.00250227.eng.abstr-s4-t1",
"arg2_id": "Herz.00250227.eng.abstr-s2-t4",
"normalized": []
},
{
"id": "Herz.00250227.eng.abstr-s2-r6-t2.1-t1.1",
"type": "affects",
"arg1_id": "Herz.00250227.eng.abstr-s4-t2",
"arg2_id": "Herz.00250227.eng.abstr-s4-t1",
"normalized": []
},
{
"id": "Herz.00250227.eng.abstr-s3-r1-t1.1-t2.1",
"type": "interacts_with",
"arg1_id": "Herz.00250227.eng.abstr-s4-t1",
"arg2_id": "Herz.00250227.eng.abstr-s4-t2",
"normalized": []
},
{
"id": "Herz.00250227.eng.abstr-s3-r2-t2.1-t1.1",
"type": "interacts_with",
"arg1_id": "Herz.00250227.eng.abstr-s4-t2",
"arg2_id": "Herz.00250227.eng.abstr-s4-t1",
"normalized": []
},
{
"id": "Herz.00250227.eng.abstr-s4-r1-t2.1-t3.1",
"type": "interacts_with",
"arg1_id": "Herz.00250227.eng.abstr-s4-t2",
"arg2_id": "Herz.00250227.eng.abstr-s4-t3",
"normalized": []
},
{
"id": "Herz.00250227.eng.abstr-s4-r2-t3.1-t1.1",
"type": "affects",
"arg1_id": "Herz.00250227.eng.abstr-s4-t3",
"arg2_id": "Herz.00250227.eng.abstr-s4-t1",
"normalized": []
},
{
"id": "Herz.00250227.eng.abstr-s4-r3-t1.1-t2.1",
"type": "produces",
"arg1_id": "Herz.00250227.eng.abstr-s4-t1",
"arg2_id": "Herz.00250227.eng.abstr-s4-t2",
"normalized": []
},
{
"id": "Herz.00250227.eng.abstr-s4-r4-t3.1-t2.1",
"type": "interacts_with",
"arg1_id": "Herz.00250227.eng.abstr-s4-t3",
"arg2_id": "Herz.00250227.eng.abstr-s4-t2",
"normalized": []
},
{
"id": "Herz.00250227.eng.abstr-s4-r5-t2.1-t1.1",
"type": "affects",
"arg1_id": "Herz.00250227.eng.abstr-s4-t2",
"arg2_id": "Herz.00250227.eng.abstr-s4-t1",
"normalized": []
}
] |
Herz.00250240.eng.abstr
|
Herz.00250240.eng.abstr
|
[
{
"id": "Herz.00250240.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Severe combined immune deficiency ( SCID ) mice have been used as an animal model to study both the direct cytopathic effect of enteroviruses on the heart in the absence of an effective immune system and to investigate the role of immune mediated processes in the pathogenesis of human myocarditis ."
],
"offsets": [
[
0,
299
]
]
}
] |
[
{
"id": "Herz.00250240.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"deficiency"
],
"offsets": [
[
23,
33
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0011155"
}
]
},
{
"id": "Herz.00250240.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"SCID"
],
"offsets": [
[
36,
40
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0085110"
}
]
},
{
"id": "Herz.00250240.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"mice"
],
"offsets": [
[
43,
47
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0025914"
}
]
},
{
"id": "Herz.00250240.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"animal"
],
"offsets": [
[
69,
75
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0003043"
},
{
"db_name": "UMLS",
"db_id": "C0003062"
}
]
},
{
"id": "Herz.00250240.eng.abstr-s1-t5",
"type": "umlsterm",
"text": [
"direct"
],
"offsets": [
[
100,
106
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0700157"
}
]
},
{
"id": "Herz.00250240.eng.abstr-s1-t6",
"type": "umlsterm",
"text": [
"enteroviruses"
],
"offsets": [
[
128,
141
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0014383"
}
]
},
{
"id": "Herz.00250240.eng.abstr-s1-t7",
"type": "umlsterm",
"text": [
"heart"
],
"offsets": [
[
149,
154
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0018787"
}
]
},
{
"id": "Herz.00250240.eng.abstr-s1-t8",
"type": "umlsterm",
"text": [
"role"
],
"offsets": [
[
223,
227
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0035820"
}
]
},
{
"id": "Herz.00250240.eng.abstr-s1-t9",
"type": "umlsterm",
"text": [
"pathogenesis"
],
"offsets": [
[
264,
276
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0543483"
}
]
},
{
"id": "Herz.00250240.eng.abstr-s1-t10",
"type": "umlsterm",
"text": [
"human"
],
"offsets": [
[
280,
285
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0020114"
}
]
},
{
"id": "Herz.00250240.eng.abstr-s1-t11",
"type": "umlsterm",
"text": [
"myocarditis"
],
"offsets": [
[
286,
297
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0027059"
}
]
},
{
"id": "Herz.00250240.eng.abstr-s1-t12",
"type": "umlsterm",
"text": [
"animal model"
],
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[
69,
81
]
],
"normalized": [
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}
] |
Herz.00250249.eng.abstr
|
Herz.00250249.eng.abstr
|
[
{
"id": "Herz.00250249.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The importance of hepatitis C virus infection has been recently noted in patients with hypertrophic cardiomyopathy or dilated cardiomyopathy . In a collaborative research project of the Committees for the Study of Idiopathic Cardiomyopathy , hepatitis C virus antibody was found in 74 of 697 patients ( 10.65 ) with hypertrophic cardiomyopathy and in 42 of 663 patients ( 6.3% ) with dilated cardiomyopathy ; these prevalences were significantly higher than that found in volunteer blood donors in Japan . Hepatitis C virus antibody was detected in 650 of 11,967 patients ( 5.4% ) seeking care in 5 academic hospitals . Various cardiac abnormalities were found , and arrhythmias were the most frequent . These observations suggest that hepatitis C virus infection is an important cause of a variety of otherwise unexplained heart diseases ."
],
"offsets": [
[
0,
840
]
]
}
] |
[
{
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],
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[
18,
27
]
],
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{
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},
{
"id": "Herz.00250249.eng.abstr-s1-t2",
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"virus"
],
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[
30,
35
]
],
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{
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}
]
},
{
"id": "Herz.00250249.eng.abstr-s1-t3",
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"infection"
],
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[
36,
45
]
],
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{
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}
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},
{
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"patients"
],
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73,
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]
],
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{
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},
{
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"hypertrophic"
],
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[
87,
99
]
],
"normalized": [
{
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]
},
{
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"cardiomyopathy"
],
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[
100,
114
]
],
"normalized": [
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]
},
{
"id": "Herz.00250249.eng.abstr-s1-t7",
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],
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126,
140
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},
{
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],
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[
18,
29
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],
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},
{
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],
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[
30,
45
]
],
"normalized": [
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]
},
{
"id": "Herz.00250249.eng.abstr-s1-t10",
"type": "umlsterm",
"text": [
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],
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[
87,
114
]
],
"normalized": [
{
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]
},
{
"id": "Herz.00250249.eng.abstr-s1-t11",
"type": "umlsterm",
"text": [
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],
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[
118,
140
]
],
"normalized": [
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]
},
{
"id": "Herz.00250249.eng.abstr-s1-t12",
"type": "umlsterm",
"text": [
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],
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[
18,
35
]
],
"normalized": [
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Herz.00250255.eng.abstr
|
Herz.00250255.eng.abstr
|
[
{
"id": "Herz.00250255.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Nitric oxide ( NO ) is an important bioactive molecule with regulatory , cytotoxic or cytoprotective properties . In virus-induced myocarditis , NO mediates host defense mechanisms against the infection or causes cardiac dysfunctions . NO is synthesized from L-arginine by the enzyme nitric oxide synthase ( NOS ) . The expression of the inducible form of the nitric oxide synthase ( iNOS ) is regulated by cytokines , involved in the complex myocardial immune response to enterovirus infections ."
],
"offsets": [
[
0,
497
]
]
}
] |
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360,
381
]
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}
] |
[] |
[] |
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{
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}
] |
Herz.00250261.eng.abstr
|
Herz.00250261.eng.abstr
|
[
{
"id": "Herz.00250261.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The sera of patients with idiopathic dilated cardiomyopathy and the Chagas ' disease contain agonist-like autoantibodies directed against the 1-adrenoceptor and/or the muscarinic M2-receptor. The anti-1-adrenoceptor antibodies could be directed against amino acid sequences of the first or second extracellular loop ."
],
"offsets": [
[
0,
317
]
]
}
] |
[
{
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"patients"
],
"offsets": [
[
12,
20
]
],
"normalized": [
{
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}
]
},
{
"id": "Herz.00250261.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"cardiomyopathy"
],
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[
45,
59
]
],
"normalized": [
{
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}
]
},
{
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"type": "umlsterm",
"text": [
"Chagas"
],
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[
68,
74
]
],
"normalized": [
{
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}
]
},
{
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"type": "umlsterm",
"text": [
"Chagas"
],
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[
68,
74
]
],
"normalized": [
{
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}
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},
{
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],
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[
77,
84
]
],
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{
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}
]
},
{
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"text": [
"agonist-like"
],
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[
93,
105
]
],
"normalized": [
{
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]
},
{
"id": "Herz.00250261.eng.abstr-s1-t7",
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"text": [
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],
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[
106,
120
]
],
"normalized": [
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}
]
},
{
"id": "Herz.00250261.eng.abstr-s1-t8",
"type": "umlsterm",
"text": [
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],
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[
216,
226
]
],
"normalized": [
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}
]
},
{
"id": "Herz.00250261.eng.abstr-s1-t9",
"type": "umlsterm",
"text": [
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],
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[
253,
258
]
],
"normalized": [
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}
]
},
{
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"text": [
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],
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[
259,
263
]
],
"normalized": [
{
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}
]
},
{
"id": "Herz.00250261.eng.abstr-s1-t11",
"type": "umlsterm",
"text": [
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],
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[
37,
59
]
],
"normalized": [
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},
{
"id": "Herz.00250261.eng.abstr-s1-t12",
"type": "umlsterm",
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],
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[
253,
263
]
],
"normalized": [
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},
{
"id": "Herz.00250261.eng.abstr-s1-t13",
"type": "umlsterm",
"text": [
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],
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[
253,
273
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0002518"
}
]
}
] |
[] |
[] |
[
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Herz.00250267.eng.abstr
|
Herz.00250267.eng.abstr
|
[
{
"id": "Herz.00250267.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Idiopathic dilated cardiomyopathy is a severe disease of unknown etiology . Accumulating evidence suggests that agonist-like autoantibodies against the 1 adrenoceptor in the circulation of dilated cardiomyopathy may play an important role . The aim of this study was to evaluate the effects of the selective 1-adrenoceptor blocker , bisoprolol , on 1-adrenoceptor peptide induced autoimmune myocardial damage ."
],
"offsets": [
[
0,
410
]
]
}
] |
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{
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{
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{
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]
}
] |
[] |
[] |
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{
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}
] |
Herz.00250271.eng.abstr
|
Herz.00250271.eng.abstr
|
[
{
"id": "Herz.00250271.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Cytokine blood levels are found to be moderately elevated in chronic heart failure , as a function of severity of disease . The source of these cytokines and the trigger mechanisms stimulating cytokine release are a matter of intense research . Potential players include bacterial endotoxin from intestinal translocation , a neurohumoral dysbalance with an enhanced sympathetic tone or an overspill of cytoines from the failing heart itself . We present arguments in favor of a direct link between the chronically enhanced sympathetic tone in heart failure and the clinically over activation of the immune system , particularly interleukin 6 release ."
],
"offsets": [
[
0,
651
]
]
}
] |
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},
{
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}
] |
[] |
[] |
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{
"id": "Herz.00250271.eng.abstr-s2-r7-t3.1-t2.1",
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},
{
"id": "Herz.00250271.eng.abstr-s2-r8-t2.1-t1.1",
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"normalized": []
},
{
"id": "Herz.00250271.eng.abstr-s3-r1-t1.1-t3.1",
"type": "affects",
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"arg2_id": "Herz.00250271.eng.abstr-s4-t3",
"normalized": []
},
{
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},
{
"id": "Herz.00250271.eng.abstr-s3-r3-t1.1-t4.1",
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},
{
"id": "Herz.00250271.eng.abstr-s4-r1-t1.1-t5.1",
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{
"id": "Herz.00250271.eng.abstr-s4-r2-t4.1-t5.1",
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{
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},
{
"id": "Herz.00250271.eng.abstr-s4-r5-t1.1-t4.1",
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},
{
"id": "Herz.00250271.eng.abstr-s4-r9-t4.1-t1.1",
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{
"id": "Herz.00250271.eng.abstr-s4-r13-t4.1-t1.1",
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{
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},
{
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"normalized": []
}
] |
Herz.00250274.eng.abstr
|
Herz.00250274.eng.abstr
|
[
{
"id": "Herz.00250274.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The pathomechanisms of autoimmune myocarditis are quite different from viral infection . In this type of myocarditis , cardiac myosin fragments , proper dentritic cells and autoreactive T cells are the 3 major elements in initiating and promoting the inflammation . The causative epitope is locating on the S2 rod portion of the myosin heavy chain ( MHC ) . Through our recombinant study , the peptide was found to be located on the latter half of MHC residues 1070 to 1165. Activity of antigenicity was not different between and chain . The cardiac dentritic cell presents a unique structure with large mononuclear and interdigitating process . This antigen presenter is quickly activated and suppressed by the antigen . The autoreactive T cell is closely linked with cytokine production . In the initial stage of myocarditis , IL-2 and IL-12 are increased . According to the progression of inflammatory changes , a great amount of IL-1b, INF- and TNF- is released around the diseased tissue . At the same time , NO is massively produced from infiltrating macrophages . Cytokines secreted from inflammatory cells accelerate T cell induction from Th0 to Th1. In the convalescent stage , production of TGF-1 and IL-10 become dominant . They contribute to cell induction from Th0 to Th2."
],
"offsets": [
[
0,
1285
]
]
}
] |
[
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"id": "Herz.00250274.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"myocarditis"
],
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34,
45
]
],
"normalized": [
{
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"db_id": "C0027059"
}
]
},
{
"id": "Herz.00250274.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"viral"
],
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[
71,
76
]
],
"normalized": [
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}
]
},
{
"id": "Herz.00250274.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"infection"
],
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[
77,
86
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0021311"
}
]
},
{
"id": "Herz.00250274.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"viral infection"
],
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71,
86
]
],
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}
]
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{
"id": "Herz.00250274.eng.abstr-s2-t1",
"type": "umlsterm",
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"myocarditis"
],
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116
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]
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"id": "Herz.00250274.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"myosin"
],
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[
127,
133
]
],
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"type": "umlsterm",
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{
"id": "Herz.00250274.eng.abstr-s2-t4",
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"cells"
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193
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{
"id": "Herz.00250274.eng.abstr-s2-t5",
"type": "umlsterm",
"text": [
"elements"
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218
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}
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{
"id": "Herz.00250274.eng.abstr-s2-t6",
"type": "umlsterm",
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"inflammation"
],
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"id": "Herz.00250274.eng.abstr-s2-t7",
"type": "umlsterm",
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"T cells"
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{
"id": "Herz.00250274.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"epitope"
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{
"id": "Herz.00250274.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"rod"
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}
]
},
{
"id": "Herz.00250274.eng.abstr-s3-t3",
"type": "umlsterm",
"text": [
"myosin"
],
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329,
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]
],
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}
]
},
{
"id": "Herz.00250274.eng.abstr-s3-t4",
"type": "umlsterm",
"text": [
"MHC"
],
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}
]
},
{
"id": "Herz.00250274.eng.abstr-s3-t5",
"type": "umlsterm",
"text": [
"myosin heavy chain"
],
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],
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]
},
{
"id": "Herz.00250274.eng.abstr-s4-t1",
"type": "umlsterm",
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"peptide"
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{
"id": "Herz.00250274.eng.abstr-s4-t2",
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"antigen"
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{
"id": "Herz.00250274.eng.abstr-s7-t2",
"type": "umlsterm",
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{
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{
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"Cytokines"
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{
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{
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}
]
}
] |
[] |
[] |
[
{
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"type": "produces",
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"normalized": []
},
{
"id": "Herz.00250274.eng.abstr-s2-r2-t5.1-t1.1",
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"arg1_id": "Herz.00250274.eng.abstr-s11-t5",
"arg2_id": "Herz.00250274.eng.abstr-s12-t1",
"normalized": []
},
{
"id": "Herz.00250274.eng.abstr-s2-r3-t7.1-t1.1",
"type": "location_of",
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},
{
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{
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Herz.00250279.eng.abstr
|
Herz.00250279.eng.abstr
|
[
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"By including immunohistochemical parameters the WHF Task Force for the Definition of Acute and Chronic Myocarditis expanded the light microscopical Dalla criteria of myocarditis . The rapid development of new molecular biological techniques such as polymerase chain reaction ( PCR ) and in-situ hybridization has improved our understanding of the underlying etiological and pathophysiological mechanisms in inflammatory heart disease . Treatment of dilated cardiomyopathy with inflammation is still controversial , however . The American Myocarditis Treatment Trial could not demonstrate a significant difference in the improvement of ejection fraction between patients with active myocarditis in the cyclosporine/prednisolone treated group when compared to placebo ."
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0,
767
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] |
Herz.00250291.eng.abstr
|
Herz.00250291.eng.abstr
|
[
{
"id": "Herz.00250291.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Giant cell myocarditis is a rare but devastating disease that usually affects young otherwise healthy individuals . Associations with tymoma , inflammatory bowel disease , and a variety of autoimmune disorders have been reported . The rate of death or heart transplantation is approximately 70% at 1 year . Data from a Lewis rat model and from observational human studies suggest that giant cell myocarditis is mediated by T lymphocytes and may respond to treatment aimed at attenuating T cell function . Recent findings from the Giant Cell Myocarditis Registry , a clinical and pathologic database from 63 cases of giant cell myocarditis gathered from 36 medical centers , include the following : The sensitivity of endomyocardial biopsy for giant cell myocarditis for patients who undergo transplantation or autopsy is 82 to 85% . Registry subjects who received cyclosporine in combination with steroid , azathioprine , or muromonab-CD3 have prolonged transplant-free survival ( 12.6 months vs. 3.0 months for no immunosuppression ) . Post-transplantation survival is approximately 71% at 5 years despite a 25% rate of giant cell infiltration in the donor heart . To confirm and extend these findings , a randomized trial of immunosuppression including muromonab-CD3, cyclosporine , and steroids is underway ."
],
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0,
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}
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] |
Herz.00250299.eng.abstr
|
Herz.00250299.eng.abstr
|
[
{
"id": "Herz.00250299.eng.abstr-passage-0",
"type": "abstract",
"text": [
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],
"offsets": [
[
0,
325
]
]
}
] |
[
{
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],
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8,
19
]
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{
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}
]
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{
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],
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61
]
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{
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],
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87
]
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{
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{
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],
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[
124,
132
]
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{
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},
{
"id": "Herz.00250299.eng.abstr-s1-t5",
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[
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167
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{
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],
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[
168,
178
]
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},
{
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],
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[
203,
215
]
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{
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236,
244
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{
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},
{
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],
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{
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}
] |
[] |
[] |
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Herz.00250331.eng.abstr
|
Herz.00250331.eng.abstr
|
[
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[] |
[] |
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},
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}
] |
Herz.00250342.eng.abstr
|
Herz.00250342.eng.abstr
|
[
{
"id": "Herz.00250342.eng.abstr-passage-0",
"type": "abstract",
"text": [
"For clinical evaluation and decision-making in patients with valvular heart disease , the diagnostic armamentarium expands steadily . This evolution makes it difficult to choose the most appropriate approach for a specific valvular lesion . It may also reflect our uncertainty of what are the findings that best predict clinical outcome of patients , e . g . after surgery . Accordingly , for each type of valvular lesion , some pathopysiological considerations are stated in order to derive the most important measures that would allow optimal guidance of patients . Based on the considerations the value of an MR study is discussed for each valvular lesion ."
],
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0,
660
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]
}
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[] |
[] |
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Herz.00250356.eng.abstr
|
Herz.00250356.eng.abstr
|
[
{
"id": "Herz.00250356.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Arrhythmogenic right ventricular dysplasia ( ARVD ) is a heart muscle disorder of unknown cause that is characterized pathologically by fibrofatty replacement of the right ventricular myocardium . Clinical manifestations include structural and functional malformations of the right ventricle , electrocardiographic abnormalities , and presentation with ventricular tachycardias with left bundle branch pattern or sudden death . The disease is often familial with an autosomal inheritance . In addition to right ventricular dilatation , right ventricular aneurysms are typical deformities of ARVD and they are distributed in the so-called \" triangle of dysplasia \" , i . e . , right ventricular outflow tract , apex , and infundibulum . Ventricular aneurysms at these sites can be considered pathognomonic of ARVD . Another typical hallmark of ARVD is fibrofatty infiltration of the right ventricular free wall . These functional and morphologic characteristics are relevant to clinical imaging investigations such as contrast angiography , echocardiography , radionuclide angiography , ultrafast computed tomography , and magnetic resonance imaging ( MRI ) . Among these techniques , MRI allows the clearest visualization of the heart , in particular because the right ventricle is involved , which is usually more difficult to explore with the other imaging modalities . Furthermore , MRI offers the specific advantage of visualizing adipose infiltration as a bright signal of the right ventricular myocardium . MRI provides the most important anatomic , functional , and morphologic criteria for diagnosis of ARVD within one single study . As a result , MRI appears to be the optimal imaging technique for detecting and following patients with clinical suspicion of ARVD ."
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Herz.00250365.eng.abstr
|
Herz.00250365.eng.abstr
|
[
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],
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0,
272
]
]
}
] |
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] |
[] |
[] |
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Herz.00250384.eng.abstr
|
Herz.00250384.eng.abstr
|
[
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761
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]
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[] |
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Herz.00250392.eng.abstr
|
Herz.00250392.eng.abstr
|
[
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"Cardiac dysfunction is a major cause of cardiovascular morbidity and mortality . Accurate and reproducible assessment of cardiac function is essential for the diagnosis , the assessment of prognosis and evaluation of a patient's response to therapy . Cardiovascular Magnetic Resonance ( CMR ) provides a measure of global and regional function that is not only accurate and reproducible but is noninvasive , free of ionising radiation , and independent of the geometric assumptions and acoustic windows that limit echocardiography . With the advent of faster scanners , automated analysis , increasing availability and reducing costs , CMR is fast becoming a clinically tenable reference standard for the measurement of cardiac function ."
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}
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[] |
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Herz.00250409.eng.abstr
|
Herz.00250409.eng.abstr
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Herz.00250417.eng.abstr
|
Herz.00250417.eng.abstr
|
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"Distinguishing between viable and non-viable myocardium is an important clinical issue . Several magnetic resonance ( MR ) techniques to address this issue have been proposed . Spectroscopy of phosphorus-31 and hydrogen-1 from creatine as well as imaging of sodium-23 and potassium-39 reflect information related to cellular metabolism . The spatial and temporal resolutions of these techniques are limited , however , by the small magnitude of the MR signal . Proton imaging techniques include examination of pathologic alterations in MR relaxation times ( T1 and T2), wall thickness and thickening , cine MRI combined with low-dose dobutamine , first-pass contrast enhancement patterns , and delayed contrast enhancement patterns . Of the proton imaging approaches , cine MRI combined with low-dose dobutamine is supported by the largest body of clinical evidence supporting the hypothesis that the technique yields useful information regarding myocardial viability . Recent data suggest that delayed contrast enhancement examines the transmural extent of viable myocardium irrespective of contractile function and that this technique should also be considered in a clinical setting ."
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0,
1186
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[] |
[] |
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Herz.00250431.eng.abstr
|
Herz.00250431.eng.abstr
|
[
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Herz.00250452.eng.abstr
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Herz.00250452.eng.abstr
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"MR spectroscopy is the only method for non-invasive detection of various aspects of cardiac metabolism in humans . While the 1H nucleus of water and fat molecules is the signal source for MR imaging , the MR spectroscopic technique allows for the study of a number of other nuclei , such as 13C , 19F , 23Na , 31P , 39K and 87Rb . Clinical applications presently are confined to the 31P nucleus . 31P-MR spectroscopy allows the non-invasive study of cardiac high-energy phosphate metabolites ATP and phosphocreatine . The phosphocreatine/ATP ratio is considered an index of the energetic state of the heart . Possible clinical indications include heart failure , valve disease and coronary artery disease . In heart failure , the phosphocreatine/ATP ratio is reduced and correlates with clinical severity , ejection fraction and prognosis . In mitral and aortic valve disease , a reduced phosphocreatine/ATP ratio may indicate the optimum timing for valve replacement . In coronary artery disease , a regional decrease of phosphocreatine during stress ( \" biochemical ergometry \" ) may indicate local ischemia . Furthermore , absolute quantification of high-energy phosphates may allow diagnosis of myocardial viability . Major technical developments , leading to improved spatial and temporal resolution will be necessary to establish MR spectroscopy as a routine clinical tool ."
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Herz.00250476.eng.abstr
|
Herz.00250476.eng.abstr
|
[
{
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"type": "abstract",
"text": [
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],
"offsets": [
[
0,
382
]
]
}
] |
[
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85
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]
},
{
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{
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{
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},
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},
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{
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235,
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},
{
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],
"normalized": [
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}
]
}
] |
[] |
[] |
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Herz.00250487.eng.abstr
|
Herz.00250487.eng.abstr
|
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"type": "interacts_with",
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},
{
"id": "Herz.00250487.eng.abstr-s2-r4-t3.2-t2.1",
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"arg2_id": "Herz.00250487.eng.abstr-s2-t2",
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},
{
"id": "Herz.00250487.eng.abstr-s2-r5-t3.1-t6.1",
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"normalized": []
},
{
"id": "Herz.00250487.eng.abstr-s2-r6-t2.1-t3.1",
"type": "diagnoses",
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"arg2_id": "Herz.00250487.eng.abstr-s2-t3",
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},
{
"id": "Herz.00250487.eng.abstr-s2-r7-t3.2-t2.1",
"type": "interacts_with",
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"arg2_id": "Herz.00250487.eng.abstr-s2-t2",
"normalized": []
},
{
"id": "Herz.00250487.eng.abstr-s2-r10-t4.1-t2.1",
"type": "uses",
"arg1_id": "Herz.00250487.eng.abstr-s2-t4",
"arg2_id": "Herz.00250487.eng.abstr-s2-t2",
"normalized": []
},
{
"id": "Herz.00250487.eng.abstr-s2-r11-t3.1-t4.1",
"type": "associated_with",
"arg1_id": "Herz.00250487.eng.abstr-s2-t3",
"arg2_id": "Herz.00250487.eng.abstr-s2-t4",
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},
{
"id": "Herz.00250487.eng.abstr-s2-r12-t3.2-t1.1",
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},
{
"id": "Herz.00250487.eng.abstr-s2-r13-t1.1-t2.1",
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},
{
"id": "Herz.00250487.eng.abstr-s2-r14-t4.1-t3.2",
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},
{
"id": "Herz.00250487.eng.abstr-s2-r15-t6.1-t3.1",
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},
{
"id": "Herz.00250487.eng.abstr-s2-r16-t2.1-t3.2",
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},
{
"id": "Herz.00250487.eng.abstr-s2-r19-t4.1-t3.1",
"type": "associated_with",
"arg1_id": "Herz.00250487.eng.abstr-s2-t4",
"arg2_id": "Herz.00250487.eng.abstr-s2-t3",
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},
{
"id": "Herz.00250487.eng.abstr-s2-r20-t2.1-t1.1",
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"arg2_id": "Herz.00250487.eng.abstr-s2-t1",
"normalized": []
}
] |
Herz.00250495.eng.abstr
|
Herz.00250495.eng.abstr
|
[
{
"id": "Herz.00250495.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The reduction of acute complications and late restenosis compared to conventional PTCA has led to a rapid increase in stent implantation as initial treatment for coronary stenosis . As a result , in-stent restenosis has become an important clinical and economical problem , especially the diffuse form , which is much more likely to reappear . In order to compare the consequences of initial stenting and initial angioplasty , we developed an analytic model , considering the differences between diffuse and focal in-stent restenosis ."
],
"offsets": [
[
0,
535
]
]
}
] |
[
{
"id": "Herz.00250495.eng.abstr-s1-t1",
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"complications"
],
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[
23,
36
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0009566"
}
]
},
{
"id": "Herz.00250495.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"PTCA"
],
"offsets": [
[
82,
86
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0002997"
}
]
},
{
"id": "Herz.00250495.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"stent"
],
"offsets": [
[
118,
123
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0038257"
}
]
},
{
"id": "Herz.00250495.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"implantation"
],
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[
124,
136
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0029976"
}
]
},
{
"id": "Herz.00250495.eng.abstr-s1-t5",
"type": "umlsterm",
"text": [
"treatment"
],
"offsets": [
[
148,
157
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0087111"
},
{
"db_name": "UMLS",
"db_id": "C0039798"
}
]
},
{
"id": "Herz.00250495.eng.abstr-s1-t6",
"type": "umlsterm",
"text": [
"stenosis"
],
"offsets": [
[
171,
179
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0009814"
}
]
},
{
"id": "Herz.00250495.eng.abstr-s1-t7",
"type": "umlsterm",
"text": [
"coronary stenosis"
],
"offsets": [
[
162,
179
]
],
"normalized": [
{
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"db_id": "C0242231"
}
]
},
{
"id": "Herz.00250495.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"in-stent"
],
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[
196,
204
]
],
"normalized": [
{
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}
]
},
{
"id": "Herz.00250495.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"form"
],
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[
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301
]
],
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}
]
},
{
"id": "Herz.00250495.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"angioplasty"
],
"offsets": [
[
413,
424
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0162577"
}
]
},
{
"id": "Herz.00250495.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"in-stent"
],
"offsets": [
[
514,
522
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0038257"
}
]
}
] |
[] |
[] |
[
{
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{
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{
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{
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{
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{
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},
{
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},
{
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{
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},
{
"id": "Herz.00250495.eng.abstr-s1-r10-t1.1-t7.1",
"type": "degree_of",
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},
{
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},
{
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},
{
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},
{
"id": "Herz.00250495.eng.abstr-s1-r14-t5.1-t4.1",
"type": "evaluation_of",
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},
{
"id": "Herz.00250495.eng.abstr-s1-r15-t3.1-t7.1",
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},
{
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},
{
"id": "Herz.00250495.eng.abstr-s1-r17-t3.1-t1.1",
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"arg2_id": "Herz.00250495.eng.abstr-s3-t1",
"normalized": []
},
{
"id": "Herz.00250495.eng.abstr-s1-r18-t1.1-t5.1",
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},
{
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},
{
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"type": "degree_of",
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},
{
"id": "Herz.00250495.eng.abstr-s1-r21-t7.1-t1.1",
"type": "degree_of",
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},
{
"id": "Herz.00250495.eng.abstr-s1-r22-t7.1-t5.1",
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"arg1_id": "Herz.00250495.eng.abstr-s1-t7",
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},
{
"id": "Herz.00250495.eng.abstr-s1-r23-t1.1-t4.1",
"type": "result_of",
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"arg2_id": "Herz.00250495.eng.abstr-s1-t4",
"normalized": []
},
{
"id": "Herz.00250495.eng.abstr-s1-r24-t1.1-t4.1",
"type": "affects",
"arg1_id": "Herz.00250495.eng.abstr-s3-t1",
"arg2_id": "Herz.00250495.eng.abstr-s1-t4",
"normalized": []
},
{
"id": "Herz.00250495.eng.abstr-s2-r1-t1.1-t2.1",
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},
{
"id": "Herz.00250495.eng.abstr-s3-r1-t1.1-t2.1",
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"arg2_id": "Herz.00250495.eng.abstr-s3-t2",
"normalized": []
}
] |
Herz.00250502.eng.abstr
|
Herz.00250502.eng.abstr
|
[
{
"id": "Herz.00250502.eng.abstr-passage-0",
"type": "abstract",
"text": [
"In Germany , cardiovascular disturbances belong to the diseases most frequently treated in the offices of general practitioners and internal specialists . With comprehensive monitoring and the taking of adequate therapeutic measures , the average mortality age of the majority of the 18 million patients suffering from circulatory diseases lies at 79.4 years ."
],
"offsets": [
[
0,
360
]
]
}
] |
[
{
"id": "Herz.00250502.eng.abstr-s1-t1",
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"Germany"
],
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[
3,
10
]
],
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}
]
},
{
"id": "Herz.00250502.eng.abstr-s1-t2",
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],
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[
55,
63
]
],
"normalized": [
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]
},
{
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],
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[
141,
152
]
],
"normalized": [
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}
]
},
{
"id": "Herz.00250502.eng.abstr-s1-t4",
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],
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106,
127
]
],
"normalized": [
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}
]
},
{
"id": "Herz.00250502.eng.abstr-s2-t1",
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],
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212,
223
]
],
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}
]
},
{
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"measures"
],
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[
224,
232
]
],
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{
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"db_id": "C0079809"
}
]
},
{
"id": "Herz.00250502.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"mortality"
],
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[
247,
256
]
],
"normalized": [
{
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"db_id": "C0026566"
},
{
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}
]
},
{
"id": "Herz.00250502.eng.abstr-s2-t4",
"type": "umlsterm",
"text": [
"age"
],
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257,
260
]
],
"normalized": [
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"db_id": "C0001792"
},
{
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"db_id": "C0001811"
}
]
},
{
"id": "Herz.00250502.eng.abstr-s2-t5",
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"text": [
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],
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[
295,
303
]
],
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}
]
},
{
"id": "Herz.00250502.eng.abstr-s2-t6",
"type": "umlsterm",
"text": [
"diseases"
],
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[
331,
339
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0012634"
}
]
}
] |
[] |
[] |
[
{
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"type": "diagnoses",
"arg1_id": "Herz.00250502.eng.abstr-s2-t4",
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},
{
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"normalized": []
},
{
"id": "Herz.00250502.eng.abstr-s1-r3-t3.1-t2.1",
"type": "diagnoses",
"arg1_id": "Herz.00250502.eng.abstr-s2-t3",
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"normalized": []
},
{
"id": "Herz.00250502.eng.abstr-s1-r4-t1.1-t2.1",
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},
{
"id": "Herz.00250502.eng.abstr-s1-r5-t2.1-t4.1",
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"arg1_id": "Herz.00250502.eng.abstr-s2-t2",
"arg2_id": "Herz.00250502.eng.abstr-s2-t4",
"normalized": []
},
{
"id": "Herz.00250502.eng.abstr-s1-r6-t2.1-t3.1",
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"arg2_id": "Herz.00250502.eng.abstr-s2-t3",
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},
{
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] |
Herz.00250526.eng.abstr
|
Herz.00250526.eng.abstr
|
[
{
"id": "Herz.00250526.eng.abstr-passage-0",
"type": "abstract",
"text": [
"In the current clinical cardiac electrophysiology well-defined and effective concepts regarding the diagnostic and treatment of cardiac arrhythmias have been intruduced . A further improvement in the cost-benefit and the cost-effectiveness relationships in several fields of cardiac electrophysiology depends on the future technical progress and on the results of ongoing and future scientific studies . On the other side very cost-saving electrophysiological treatments had been developed ; the broader clinical use of these treatments is a possibility to optimize the costs for patients ' care with cardiac arrhythmias ."
],
"offsets": [
[
0,
622
]
]
}
] |
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[] |
[] |
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"type": "performs",
"arg1_id": "Herz.00250526.eng.abstr-s3-t1",
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"normalized": []
},
{
"id": "Herz.00250526.eng.abstr-s3-r13-t10.1-t1.1",
"type": "occurs_in",
"arg1_id": "Herz.00250526.eng.abstr-s3-t10",
"arg2_id": "Herz.00250526.eng.abstr-s3-t1",
"normalized": []
},
{
"id": "Herz.00250526.eng.abstr-s3-r14-t10.1-t1.1",
"type": "associated_with",
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"arg2_id": "Herz.00250526.eng.abstr-s3-t1",
"normalized": []
}
] |
Herz.00250538.eng.abstr
|
Herz.00250538.eng.abstr
|
[
{
"id": "Herz.00250538.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The economic burden of congestive heart failure is significant . Approximately 1 to 2% of total health care expenditure is attributed to the diagnosis , treatment and prevention of congestive heart failure . A great share of this expenditure is related to the costs of long-term complications and productivity losses . In order to manage these costs , providers and policymakers increasingly have to focus on economicaly attractive interventions ."
],
"offsets": [
[
0,
447
]
]
}
] |
[
{
"id": "Herz.00250538.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"economic"
],
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[
4,
12
]
],
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{
"db_name": "UMLS",
"db_id": "C0013557"
}
]
},
{
"id": "Herz.00250538.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"heart"
],
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[
34,
39
]
],
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{
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"db_id": "C0018787"
}
]
},
{
"id": "Herz.00250538.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"congestive heart failure"
],
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[
23,
47
]
],
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{
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"db_id": "C0018802"
}
]
},
{
"id": "Herz.00250538.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"health"
],
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[
96,
102
]
],
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{
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"db_id": "C0018684"
}
]
},
{
"id": "Herz.00250538.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"care"
],
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[
103,
107
]
],
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{
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}
]
},
{
"id": "Herz.00250538.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"expenditure"
],
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[
108,
119
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0015316"
}
]
},
{
"id": "Herz.00250538.eng.abstr-s2-t4",
"type": "umlsterm",
"text": [
"diagnosis"
],
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[
141,
150
]
],
"normalized": [
{
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"db_id": "C0011900"
},
{
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"db_id": "C0348026"
}
]
},
{
"id": "Herz.00250538.eng.abstr-s2-t5",
"type": "umlsterm",
"text": [
"treatment"
],
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[
153,
162
]
],
"normalized": [
{
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"db_id": "C0087111"
},
{
"db_name": "UMLS",
"db_id": "C0039798"
}
]
},
{
"id": "Herz.00250538.eng.abstr-s2-t6",
"type": "umlsterm",
"text": [
"prevention"
],
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[
167,
177
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0687732"
}
]
},
{
"id": "Herz.00250538.eng.abstr-s2-t7",
"type": "umlsterm",
"text": [
"heart"
],
"offsets": [
[
192,
197
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0018787"
}
]
},
{
"id": "Herz.00250538.eng.abstr-s2-t8",
"type": "umlsterm",
"text": [
"health care"
],
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[
96,
107
]
],
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{
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"db_id": "C0086388"
}
]
},
{
"id": "Herz.00250538.eng.abstr-s2-t9",
"type": "umlsterm",
"text": [
"congestive heart failure"
],
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[
181,
205
]
],
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{
"db_name": "UMLS",
"db_id": "C0018802"
}
]
},
{
"id": "Herz.00250538.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"expenditure"
],
"offsets": [
[
230,
241
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0015316"
}
]
},
{
"id": "Herz.00250538.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"costs"
],
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[
260,
265
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0010186"
},
{
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},
{
"db_name": "UMLS",
"db_id": "C0220812"
}
]
},
{
"id": "Herz.00250538.eng.abstr-s3-t3",
"type": "umlsterm",
"text": [
"complications"
],
"offsets": [
[
279,
292
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0009566"
}
]
},
{
"id": "Herz.00250538.eng.abstr-s3-t4",
"type": "umlsterm",
"text": [
"productivity"
],
"offsets": [
[
297,
309
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0033269"
}
]
},
{
"id": "Herz.00250538.eng.abstr-s4-t1",
"type": "umlsterm",
"text": [
"costs"
],
"offsets": [
[
344,
349
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0010186"
},
{
"db_name": "UMLS",
"db_id": "C0010181"
},
{
"db_name": "UMLS",
"db_id": "C0220812"
}
]
},
{
"id": "Herz.00250538.eng.abstr-s4-t2",
"type": "umlsterm",
"text": [
"economicaly"
],
"offsets": [
[
409,
420
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0013557"
}
]
}
] |
[] |
[] |
[
{
"id": "Herz.00250538.eng.abstr-s1-r1-t1.1-t3.1",
"type": "location_of",
"arg1_id": "Herz.00250538.eng.abstr-s4-t1",
"arg2_id": "Herz.00250538.eng.abstr-s3-t3",
"normalized": []
},
{
"id": "Herz.00250538.eng.abstr-s2-r1-t4.2-t5.1",
"type": "location_of",
"arg1_id": "Herz.00250538.eng.abstr-s2-t4",
"arg2_id": "Herz.00250538.eng.abstr-s2-t5",
"normalized": []
},
{
"id": "Herz.00250538.eng.abstr-s2-r2-t3.1-t4.2",
"type": "conceptual_part_of",
"arg1_id": "Herz.00250538.eng.abstr-s3-t3",
"arg2_id": "Herz.00250538.eng.abstr-s2-t4",
"normalized": []
},
{
"id": "Herz.00250538.eng.abstr-s2-r3-t1.1-t2.1",
"type": "conceptually_related_to",
"arg1_id": "Herz.00250538.eng.abstr-s4-t1",
"arg2_id": "Herz.00250538.eng.abstr-s4-t2",
"normalized": []
},
{
"id": "Herz.00250538.eng.abstr-s2-r4-t3.1-t5.1",
"type": "conceptual_part_of",
"arg1_id": "Herz.00250538.eng.abstr-s3-t3",
"arg2_id": "Herz.00250538.eng.abstr-s2-t5",
"normalized": []
},
{
"id": "Herz.00250538.eng.abstr-s2-r5-t8.1-t6.1",
"type": "associated_with",
"arg1_id": "Herz.00250538.eng.abstr-s2-t8",
"arg2_id": "Herz.00250538.eng.abstr-s2-t6",
"normalized": []
},
{
"id": "Herz.00250538.eng.abstr-s2-r6-t8.1-t4.2",
"type": "associated_with",
"arg1_id": "Herz.00250538.eng.abstr-s2-t8",
"arg2_id": "Herz.00250538.eng.abstr-s2-t4",
"normalized": []
},
{
"id": "Herz.00250538.eng.abstr-s2-r7-t3.1-t6.1",
"type": "conceptual_part_of",
"arg1_id": "Herz.00250538.eng.abstr-s3-t3",
"arg2_id": "Herz.00250538.eng.abstr-s2-t6",
"normalized": []
},
{
"id": "Herz.00250538.eng.abstr-s2-r8-t8.1-t5.1",
"type": "associated_with",
"arg1_id": "Herz.00250538.eng.abstr-s2-t8",
"arg2_id": "Herz.00250538.eng.abstr-s2-t5",
"normalized": []
},
{
"id": "Herz.00250538.eng.abstr-s2-r9-t2.1-t8.1",
"type": "isa",
"arg1_id": "Herz.00250538.eng.abstr-s4-t2",
"arg2_id": "Herz.00250538.eng.abstr-s2-t8",
"normalized": []
},
{
"id": "Herz.00250538.eng.abstr-s2-r10-t3.1-t1.1",
"type": "isa",
"arg1_id": "Herz.00250538.eng.abstr-s3-t3",
"arg2_id": "Herz.00250538.eng.abstr-s4-t1",
"normalized": []
},
{
"id": "Herz.00250538.eng.abstr-s2-r11-t2.1-t1.1",
"type": "isa",
"arg1_id": "Herz.00250538.eng.abstr-s4-t2",
"arg2_id": "Herz.00250538.eng.abstr-s4-t1",
"normalized": []
},
{
"id": "Herz.00250538.eng.abstr-s2-r12-t8.1-t2.1",
"type": "associated_with",
"arg1_id": "Herz.00250538.eng.abstr-s2-t8",
"arg2_id": "Herz.00250538.eng.abstr-s4-t2",
"normalized": []
},
{
"id": "Herz.00250538.eng.abstr-s2-r13-t2.1-t6.1",
"type": "precedes",
"arg1_id": "Herz.00250538.eng.abstr-s4-t2",
"arg2_id": "Herz.00250538.eng.abstr-s2-t6",
"normalized": []
},
{
"id": "Herz.00250538.eng.abstr-s2-r14-t8.1-t2.1",
"type": "result_of",
"arg1_id": "Herz.00250538.eng.abstr-s2-t8",
"arg2_id": "Herz.00250538.eng.abstr-s4-t2",
"normalized": []
},
{
"id": "Herz.00250538.eng.abstr-s2-r15-t4.2-t8.1",
"type": "location_of",
"arg1_id": "Herz.00250538.eng.abstr-s2-t4",
"arg2_id": "Herz.00250538.eng.abstr-s2-t8",
"normalized": []
},
{
"id": "Herz.00250538.eng.abstr-s2-r16-t2.1-t1.1",
"type": "conceptually_related_to",
"arg1_id": "Herz.00250538.eng.abstr-s4-t2",
"arg2_id": "Herz.00250538.eng.abstr-s4-t1",
"normalized": []
},
{
"id": "Herz.00250538.eng.abstr-s2-r17-t2.1-t3.1",
"type": "measures",
"arg1_id": "Herz.00250538.eng.abstr-s4-t2",
"arg2_id": "Herz.00250538.eng.abstr-s3-t3",
"normalized": []
},
{
"id": "Herz.00250538.eng.abstr-s2-r18-t2.1-t4.2",
"type": "precedes",
"arg1_id": "Herz.00250538.eng.abstr-s4-t2",
"arg2_id": "Herz.00250538.eng.abstr-s2-t4",
"normalized": []
},
{
"id": "Herz.00250538.eng.abstr-s2-r19-t4.2-t2.1",
"type": "location_of",
"arg1_id": "Herz.00250538.eng.abstr-s2-t4",
"arg2_id": "Herz.00250538.eng.abstr-s4-t2",
"normalized": []
},
{
"id": "Herz.00250538.eng.abstr-s2-r20-t2.1-t4.2",
"type": "conceptual_part_of",
"arg1_id": "Herz.00250538.eng.abstr-s4-t2",
"arg2_id": "Herz.00250538.eng.abstr-s2-t4",
"normalized": []
},
{
"id": "Herz.00250538.eng.abstr-s2-r21-t2.1-t5.1",
"type": "precedes",
"arg1_id": "Herz.00250538.eng.abstr-s4-t2",
"arg2_id": "Herz.00250538.eng.abstr-s2-t5",
"normalized": []
},
{
"id": "Herz.00250538.eng.abstr-s2-r22-t2.1-t5.1",
"type": "conceptual_part_of",
"arg1_id": "Herz.00250538.eng.abstr-s4-t2",
"arg2_id": "Herz.00250538.eng.abstr-s2-t5",
"normalized": []
},
{
"id": "Herz.00250538.eng.abstr-s2-r23-t2.1-t6.1",
"type": "conceptual_part_of",
"arg1_id": "Herz.00250538.eng.abstr-s4-t2",
"arg2_id": "Herz.00250538.eng.abstr-s2-t6",
"normalized": []
},
{
"id": "Herz.00250538.eng.abstr-s2-r24-t4.2-t6.1",
"type": "location_of",
"arg1_id": "Herz.00250538.eng.abstr-s2-t4",
"arg2_id": "Herz.00250538.eng.abstr-s2-t6",
"normalized": []
},
{
"id": "Herz.00250538.eng.abstr-s2-r25-t2.1-t8.1",
"type": "associated_with",
"arg1_id": "Herz.00250538.eng.abstr-s4-t2",
"arg2_id": "Herz.00250538.eng.abstr-s2-t8",
"normalized": []
}
] |
Herz.00250547.eng.abstr
|
Herz.00250547.eng.abstr
|
[
{
"id": "Herz.00250547.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Ischemic heart disease is the most frequent cause of death in industrialized countries . This is a result of persistent risk factors and aging of the population . Medical progress with application of conservative , surgical or interventional strategies indeed reduced the morbidity and mortality of arteriosclerotic diseases , but markedly increased the medical care costs . The result is a discussion about the optimal use of the different therapeutic measures under consideration of the evidence based medicine ."
],
"offsets": [
[
0,
514
]
]
}
] |
[
{
"id": "Herz.00250547.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"Ischemic"
],
"offsets": [
[
0,
8
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0022116"
}
]
},
{
"id": "Herz.00250547.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"heart"
],
"offsets": [
[
9,
14
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0018787"
}
]
},
{
"id": "Herz.00250547.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"disease"
],
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[
15,
22
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0012634"
}
]
},
{
"id": "Herz.00250547.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"cause"
],
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[
44,
49
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0015127"
}
]
},
{
"id": "Herz.00250547.eng.abstr-s1-t5",
"type": "umlsterm",
"text": [
"death"
],
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[
53,
58
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0011065"
}
]
},
{
"id": "Herz.00250547.eng.abstr-s1-t6",
"type": "umlsterm",
"text": [
"heart disease"
],
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[
9,
22
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0018799"
}
]
},
{
"id": "Herz.00250547.eng.abstr-s1-t7",
"type": "umlsterm",
"text": [
"industrialized countries"
],
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[
62,
86
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0282613"
}
]
},
{
"id": "Herz.00250547.eng.abstr-s1-t8",
"type": "umlsterm",
"text": [
"Ischemic heart disease"
],
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[
0,
22
]
],
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{
"db_name": "UMLS",
"db_id": "C0151744"
}
]
},
{
"id": "Herz.00250547.eng.abstr-s1-t9",
"type": "umlsterm",
"text": [
"cause of death"
],
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[
44,
58
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0007465"
}
]
},
{
"id": "Herz.00250547.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"risk"
],
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[
120,
124
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0035647"
}
]
},
{
"id": "Herz.00250547.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"population"
],
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[
150,
160
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0032659"
}
]
},
{
"id": "Herz.00250547.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"risk factors"
],
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[
120,
132
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0035648"
}
]
},
{
"id": "Herz.00250547.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"surgical"
],
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[
215,
223
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0038895"
}
]
},
{
"id": "Herz.00250547.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"morbidity"
],
"offsets": [
[
272,
281
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0220880"
},
{
"db_name": "UMLS",
"db_id": "C0026538"
}
]
},
{
"id": "Herz.00250547.eng.abstr-s3-t3",
"type": "umlsterm",
"text": [
"mortality"
],
"offsets": [
[
286,
295
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0026566"
},
{
"db_name": "UMLS",
"db_id": "C0026565"
}
]
},
{
"id": "Herz.00250547.eng.abstr-s3-t4",
"type": "umlsterm",
"text": [
"diseases"
],
"offsets": [
[
316,
324
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0012634"
}
]
},
{
"id": "Herz.00250547.eng.abstr-s3-t5",
"type": "umlsterm",
"text": [
"care"
],
"offsets": [
[
362,
366
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0150499"
}
]
},
{
"id": "Herz.00250547.eng.abstr-s3-t6",
"type": "umlsterm",
"text": [
"costs"
],
"offsets": [
[
367,
372
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0010186"
},
{
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[] |
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] |
Herz.00250557.eng.abstr
|
Herz.00250557.eng.abstr
|
[
{
"id": "Herz.00250557.eng.abstr-passage-0",
"type": "abstract",
"text": [
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],
"offsets": [
[
0,
580
]
]
}
] |
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[] |
[] |
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] |
Herz.00250570.eng.abstr
|
Herz.00250570.eng.abstr
|
[
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],
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[
0,
625
]
]
}
] |
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}
] |
[] |
[] |
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] |
Herz.00250579.eng.abstr
|
Herz.00250579.eng.abstr
|
[
{
"id": "Herz.00250579.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The clinical and experimental data relevant to the theoretical mechanisms and clinical results of laser myocardial \" revascularization \" are reviewed . Both transmyocardial ( TMR ) and percutaneous ( PMR ) approaches are considered . Special attention is paid to the issue of TMR-induced angiogenesis . Both TMR and PMR result in a reduction in angina symptoms in patients refractory to conventional therapy and are likely to act through common pathways . TMR-induced angiogenesis appears to result from the up-regulation of vascular growth factors . However , the available data suggest that the angiogenic response is not a unique consequence of laser revascularization . Rather , the angiogenesis associated with TMR is likely to be a non-specific response of the myocardium to injury ."
],
"offsets": [
[
0,
789
]
]
}
] |
[
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],
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98,
103
]
],
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}
]
},
{
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"type": "umlsterm",
"text": [
"attention"
],
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[
242,
251
]
],
"normalized": [
{
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}
]
},
{
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],
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[
345,
351
]
],
"normalized": [
{
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}
]
},
{
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"type": "umlsterm",
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],
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352,
360
]
],
"normalized": [
{
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},
{
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372
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},
{
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],
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407
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],
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]
},
{
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},
{
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],
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540
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{
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}
]
},
{
"id": "Herz.00250579.eng.abstr-s5-t3",
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"text": [
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],
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[
534,
548
]
],
"normalized": [
{
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}
]
},
{
"id": "Herz.00250579.eng.abstr-s6-t1",
"type": "umlsterm",
"text": [
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],
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648,
653
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"normalized": [
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]
},
{
"id": "Herz.00250579.eng.abstr-s7-t1",
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],
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},
{
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"type": "umlsterm",
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],
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"normalized": [
{
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},
{
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"db_id": "C0021501"
}
]
}
] |
[] |
[] |
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] |
Herz.00250589.eng.abstr
|
Herz.00250589.eng.abstr
|
[
{
"id": "Herz.00250589.eng.abstr-passage-0",
"type": "abstract",
"text": [
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],
"offsets": [
[
0,
363
]
]
}
] |
[
{
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{
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}
]
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{
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],
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{
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{
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}
] |
[] |
[] |
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Herz.00250600.eng.abstr
|
Herz.00250600.eng.abstr
|
[
{
"id": "Herz.00250600.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The identification of angiogenetic growth factors was the basis for the development of novel strategies for the treatment of occlusive vascular diseases . Therapeutic angiogenesis resulting in capillary sprouting ( angiogenesis ) and collateral vessel development ( arteriogenesis ) may be a potential alternative for patients suffering from critical limb ischemia . Extensive investigations performed in vitro and in vivo demonstrated therapeutic efficacy through the enhancement of collateral growth resulting in augmented blood flow in ischemic tissues following administration of both , recombinant growth factors and genes encoding for such factors ."
],
"offsets": [
[
0,
655
]
]
}
] |
[
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],
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4,
18
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] |
Herz.00250623.eng.abstr
|
Herz.00250623.eng.abstr
|
[
{
"id": "Herz.00250623.eng.abstr-passage-0",
"type": "abstract",
"text": [
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}
] |
[] |
[] |
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}
] |
Herz.00250627.eng.abstr
|
Herz.00250627.eng.abstr
|
[
{
"id": "Herz.00250627.eng.abstr-passage-0",
"type": "abstract",
"text": [
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],
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[
0,
297
]
]
}
] |
[
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}
] |
[] |
[] |
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Herzschrittmachertherapie.00110004.eng.abstr
|
Herzschrittmachertherapie.00110004.eng.abstr
|
[
{
"id": "Herzschrittmachertherapie.00110004.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The need for overcoming the limitations of the conventional mapping technique and recent technical progress have brought several new mapping techniques into the practice of clinical electrophysiology , among them mapping with multielectrode basket catheters . The multielectrode basket catheter represents a basket-shaped array of electrodes distributed evenly on linear support structures called splines . It provides simultaneous recordings of unipolar or bipolar electrograms within the heart chamber in which it is deployed . Experimental and clinical data provide information on the advantages of using basket catheters for mapping and ablation of atrial and ventricular arrhythmia . Reports of the available studies show that the mapping with a basket catheter is a safe procedure . The low resolution , the poor maneuverability , and the inability to make close contact with the whole endocardial surface due to a poor matching between the basket catheter electrode arrays and the heart chamber anatomy are considered as the most serious limitations of the currently available generation of the basket catheters . From the data available , it could be concluded that the complex or unstable arrhythmias might be the main indication for the use of multielectrode basket catheters in the electrophysiological studies ."
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] |
[] |
[] |
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Herzschrittmachertherapie.00110011.eng.abstr
|
Herzschrittmachertherapie.00110011.eng.abstr
|
[
{
"id": "Herzschrittmachertherapie.00110011.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Epicardial structures are only rarely used for mapping and ablation of supraventricular and ventricular arrhythmias with the exception of WPW syndromes . However in a small percentage of patients obviously presenting an epicardial course of their arrhythmogenic structures , it may become necessary to seek out coronary veins and arteries in order to localize and eventually directly ablate the foci . Only single experiences are available in coronary vein mapping for ventricular tachycardias . In particular non-ischemic conditions like Chagas ' disease , dilative cardiomyopathy and idiopathic left ventricular tachycardias tend to demonstrate an epicardial origin respectively breakthrough . By multipolar mapping using 2-3 French microcatheters with up to 16 poles , almost all coronary vein regions and arrhythmogenic foci can be reached respectively identified . In exceptional cases , microcatheter mapping may also be carried out in coronary arteries for localizing ventricular tachycardias for example due to remote myocardial infarction . Recently a direct approach to the epicardial space by transthoracic pericardial puncture has been introduced to perform a complete mapping of the epicardial surface not being limited by vascular structures . While coronary vein mapping can be considered a safe , reliable and helpful aid in identifying and localizing epicardial arrhythmogenic foci , the different ablative procedures still need to be evaluated and standardized with respect to safety and efficacy . Multipolar basket mapping means an endocardial mapping procedure using a flexible basket consisting of up to 8 arms provided with multiple electrodes . After introducing the basket through a guiding catheter into the ventricle , the basket is distended and attached to the endocardium . An induced ventricular tachycardia may be mapped in seconds making this technique advantageous for nonsustained ventricular tachycardias . Initial results indicate basket mapping to be efficacious and relatively safe . At present , computer-based animation techniques are being evaluated for the transfer of the large amount of endocardial signal data registered into a three-dimensional coordinate system in order to guide the ablation catheter . Before basket mapping may be considered a clinically established tool , further developments and studies comparing basket with other mapping techniques are needed ."
],
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0,
2416
]
]
}
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] |
[] |
[] |
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}
] |
Herzschrittmachertherapie.00110031.eng.abstr
|
Herzschrittmachertherapie.00110031.eng.abstr
|
[
{
"id": "Herzschrittmachertherapie.00110031.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The spread of electrical endo- and epicardial activation is projected also to body surface and can be deducted from various numbers of recording points at the front or the back of the thorax . The resulting data are visualized in a body surface map ( BSM ) ."
],
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[
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]
}
] |
[
{
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"thorax"
],
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{
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"map"
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}
]
},
{
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"body surface map"
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{
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]
}
] |
[] |
[] |
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{
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},
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},
{
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"type": "analyzes",
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"arg2_id": "Herzschrittmachertherapie.00110031.eng.abstr-s2-t1",
"normalized": []
}
] |
Herzschrittmachertherapie.00110052.eng.abstr
|
Herzschrittmachertherapie.00110052.eng.abstr
|
[
{
"id": "Herzschrittmachertherapie.00110052.eng.abstr-passage-0",
"type": "abstract",
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"Implantable cardioverter/defibrillators ( ICD ) have led to a reduction in cardiac mortality in patients with ventricular tachyarrhythmias . A considerable number of patients experience repeated shocks which may have an impact on the quality of life ."
],
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]
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] |
[] |
[] |
[
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{
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},
{
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{
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"type": "occurs_in",
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"arg2_id": "Herzschrittmachertherapie.00110052.eng.abstr-s2-t1",
"normalized": []
}
] |
Herzschrittmachertherapie.00110059.eng.abstr
|
Herzschrittmachertherapie.00110059.eng.abstr
|
[
{
"id": "Herzschrittmachertherapie.00110059.eng.abstr-passage-0",
"type": "abstract",
"text": [
"In the past , most scientific or routine studies on heart rate variability ( HRV ) were done using commercial Holter ECG devices with traditional magnetic tapes . All methods to calculate parameters of HRV are based on the measurement of time intervals between successive sinus cardiac beats , in practice RR intervals . Hence , results of HRV calculation depend on the quality of primary data acquisition . However , technical standards on accuracy of RR interval acquisition in magnetic tape and digital solid state Holter ECG systems do not exist as yet . Therefore in a laboratory investigation accuracy of HRV parameter calculation after traditional standard tape with and without real-time analysis and digital solid state data acquisition was compared in three commercial Holter ECG systems [ Ela medical ( E ) , Oxford Medilog Excel ( O ) and Medset Cardiolight ( M ) ] . A computer-based ECG simulator was used to synthesize a test signal consisting of artificial P-QRS complexes of fixed rate , quartz stabilized \" sinus rhythms \" . Two channel analog tape and digital 24h recordings of the fixed rate test signal were performed simultaneously . The influence of recording technology on accuracy of RR interval measurement and consequently on time domaine HRV was shown by comparing five standard 24-h time domain parameters . As expected , in the three Holter systems the analog tape recordings showed a higher , technically induced , artificial RR variability . The SDNN values ( E : 9.38ms vs 2.68ms ; p 0.001 ; O : 3.89ms vs 0.97ms ; p 0.001 ; M : 10.47ms vs 2.89ms ; p=0.001), SDNN-Index values ( E : 8.22ms vs 0.90ms ; p 0.001 ; O : 3.75ms vs 0.90ms ; p 0.001 ; M : 7.81ms vs 1.49ms , p 0.001 ) and RMSSD-values ( E : 10.39ms vs 2.16ms ; p 0.001 ; O : 10.05ms vs 1.88ms , p 0.001 ; M : 8.62ms vs 1.69ms ; p 0.001 ) were significantly lower if acquisition was done by digital solid devices in all systems , SDANN ( M : 9.83ms vs 5.37ms ; p 0.001 ) in the Medset system too . The used method is a possible way to validate commercial Holter ECG systems for HRV analysis . Clinical significance of artifical HRV seems to be low ."
],
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0,
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"Background : Evidence-based medicine is a popular movement . It claims that decisions on diagnosis and treatment should be based not merely on intuition , personal experience and pathophysiological reasoning , but rather on external evidence from clinical research . It offers a method of systematic literature search combined with a critical appraisal of the findings that can be learned in special teaching programs . Aim : Discussion of the advantages and disadvantages of the approach . Methods : Critical appraisal of the validity and usefulness of evidence-based medicine , along the lines of its own method . Results : While every single step of the method of evidence-based medicine is well described and can be learned systematically , the key term \" evidence \" is vague . There is no automatic method to state evidence , and evidence is in its nature preliminary and less objective than usually assumed . However , although ultimate answers are not to be expected , the systematic strive for the best available evidence may improve medical practice substantially , although a definite proof of this suggestion is outstanding . Conclusions : Since the alternative to striving for external evidence would be ignorance , evidence-based medicine is mandatory for ethical reasons , and only the best way can be a question of debate . Despite its virtues , evidence-based medicine can be misunderstood and abused for political purposes or aggressive marketing strategies . Such an abuse does definitely not meet the intentions of the creators ."
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Herzschrittmachertherapie.00110102.eng.abstr
|
Herzschrittmachertherapie.00110102.eng.abstr
|
[
{
"id": "Herzschrittmachertherapie.00110102.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Background : High specifity and high positive prediction have been reached in risk stratification for SCD after AMI by combining multiple methods . However , sensitivity and positive prediction are still not satisfying . One of these methods is the measurement of HRV , established as an independent predictor for SCD . Actually , HRV is used in cardiology , diabetology and neonatology to obtain quick assessment of the present state of the autonomic nervous system . Aim of the study : We studied the short-term measurement of HRV in patients after AMI as an additional method for risk stratification . Method : We performed one measurement over 5 minutes at rest and one with parasympathetic stimulation by regularized breathing in 158 patients 11 +/- 5 days after AMI . The measurement was repeated immediately and after one week . 87 patients had an additional Holter ECG . Results : Correlation of two consecutive measurements showed a Pearson's correlation coefficient between 0.87 and 0.95. Comparing short- and long-term measurement , only the parameters obtained at rest showed satisfying correlations , but not the parameters representing parasympathetic activity . There was no correlation between HRV and age and , for measurement with parasympathetic stimulation , between HRV and diabetes . Conclusions : Short-term measurement of HRV has an excellent reproducibility and provides reliable information about the balance of the autonomic nervous system . After defining cut-off values and evaluating the method with patients at high risk for SCD , it seems to be a simple and quick method for risk stratification after AMI . Finally , it can also be used for evaluation of patients with diabetes ."
],
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0,
1711
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Herzschrittmachertherapie.00110110.eng.abstr
|
Herzschrittmachertherapie.00110110.eng.abstr
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[
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"id": "Herzschrittmachertherapie.00110110.eng.abstr-passage-0",
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"The accuracy of the RR interval data acquisition is an essential prerequisite for reliable analysis of heart rate variability ( HRV ) . In previous laboratory investigations , in which computerized electrocardiograms were simultaneously sampled at identical heart rates using digital and analog tape recorders , the superiority of the digital recorders was clearly demonstrated . Conventional tape recordings exhibit technical variability which may produce false positive HRV results . However , the clinical significance of this type of variability is not known . Aim of the study : To characterize the clinical relevance of technical RR variability related to the conventional tape recording process . Methods : In 20 patients with cardiac disease and stable sinus rhythm , 24-hour Holter monitoring was performed by connecting each patient simultaneously to a conventional tape and a digital Holter recorder ( Ela medical ) via the same leads . Technical variability was defined as the difference between the HRV results obtained by the respective analog ( A ) and digital ( D ) recording methods . Results : For the following HRV indices significant A-D differences were found : SDNNindex : 38.47ms ( A ) vs. 36.17ms , p=0.003; RMSSD : 25.04ms ( A ) vs. 21.09ms ( D ) , p 0.001 ; pNN50: 3.70% ( A ) vs. 2.40% ( D ) , p=0.006; Total power : 1200.20ms2 ( A ) vs. 1076.55ms2 ( D ) , p=0.032; LF power : 287.35ms2 ( A ) vs. 243.80ms2 ( D ) , p=0.035; HF power : 72.50ms2 ( A ) vs. 54.95ms2 ( D ) ; p=0.001, and the LF/HF ratio : 4.47 ( A ) vs. 5.33 ( D ) , p=0.037. No significant differenes were found for the following indices : SDNN : 95.59ms ( A ) vs. 94.74ms ( D ) , p=0.29; and SDANN : 85.52ms ( A ) vs. 85.08ms ( D ) , p=0.68. Conclusions : Under both experimental and clinical conditions , higher HRV values were found in the conventional ( tape ) recordings . However , the technical variability was small in comparison with the mean values of normal HRV indices and their standard deviation . Thus , differences due to different recorder technology may be neglected in clinical practice . Nevertheless , in scientific HRV trials , it seems wise to use digital Holter recorders ."
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[] |
[] |
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Herzschrittmachertherapie.00110117.eng.abstr
|
Herzschrittmachertherapie.00110117.eng.abstr
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[
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"id": "Herzschrittmachertherapie.00110117.eng.abstr-passage-0",
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"text": [
"Intraartial conduction disturbances ( IACD ) are the known substrate of re-entrant atrial arrhythmias and their diagnosis is important for the selection of proper therapy . Signs of IACD can be missed on the standard ECG , and signal averaged ( SA ) P wave analysis has proved valuable for the evaluation of electrophysiological ( EPS ) properties of atrial myocardium . Unfavourable EPS effects of RAA pacing are known to electrophysiologists , but this aspect is rarely considered in normal practice , and RAA based pacing modes remain standard even for pts . with IACD . We examined and compared EPS effects of different atrial pacing modes using two diagnostic tools : IEGM obtained from two atrial leads of biatrial pacing system ( via telemetry ) and time domain analysis of SA P wave in 22 pts . with BiA pacing system ( implanted due to atrial arrhythmias and IACD ) . The results showed that different atrial pacing modes influence atrial activation timing parameters differently : RAA pacing aggravates IACD in comparison to sinus rhythm ; the effects of CS pacing is less visible . BiA pacing normalises all atrial activation times . The normalisation of SA P wave duration , reduction of SA P wave dispersion , increasing of RMS 20 and decreasing of LAS 5 and finally abolition of presence of late atrial potentials in most of pts . indicates beneficial effects of BiA pacing ( in pts . with IACD ) in comparison to sinus rhythm and RAA pacing . Unfavourable EPS effects of RAA pacing in patients with IACD indicates suitability the need for alternative ( resynchronising ) atrial pacing modes . Time domain analysis of SA P wave is a valuable and sensitive diagnostic tool for non-invasive evaluation of EPS effects of different modes of atrial pacing ."
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[] |
[] |
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"In this review the importance of nonlinear analysis of heart rate variability is discussed . In the introduction the complexity of the heart rate signal is highlighted which reflects an abundance of external and internal control mechanisms . It is shown that one way to improve analysis of heart rate variability in terms of risk prediction is \" perturbation \" analysis . In this system analysis approach , the response of heart rate to a specific perturbation rather than the global dynamics of a 24 hour recording are analyzed . Prominent examples of this approach are \" heart rate turbulence \" and \" heart rate recovery \" . After mentioning 1/f-fluctuations as the dominant but still linear phenomenon in spectral analysis of heart rate variability , the remainder of the review is focused on the return map . Fundamental properties of the return map of heart rate are delineated which clearly demonstrate nonlinear properties of the heart rate signal . In addition , practical aspects of return map analysis are reviewed which prove to be very fruitful in the handling of heart rate data ."
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Herzschrittmachertherapie.00110159.eng.abstr
|
Herzschrittmachertherapie.00110159.eng.abstr
|
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"The main intention of this contribution is to discuss different nonlinear approaches to heart rate and blood pressure variability analysis for a better understanding of the cardiovascular regulation . We investigate measures of complexity which are based on symbolic dynamics , renormalised entropy and the finite time growth rates . The dual sequence method to estimate the baroreflex sensitivity and the maximal correlation method to estimate the nonlinear coupling between time series are employed for analysing bivariate data . The latter appears to be a suitable method to estimate the strength of the nonlinear coupling and the coupling direction . Heart rate and blood pressure data from clinical pilot studies and from very large clinical studies are analysed . We demonstrate that parameters from nonlinear dynamics are useful for risk stratification after myocardial infarction , for the prediction of life-threatening cardiac events even in short time series , and for modelling the relationship between heart rate and blood pressure regulation . These findings could be of importance for clinical diagnostics , in algorithms for risk stratification , and for therapeutic and preventive tools of next generation implantable cardioverter defibrillators ."
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"type": "abstract",
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"Background : The role of the cardiovascular system is to keep up an adequate perfusion pressure in order to maintain the homeostasis in the organism . In this context , the baroreceptor reflex , as the short-term mechanism , is of major importance . As a result of chronotropic incompetence , e.g. because of a dysfunction of the sinus node , the control mechanisms of the baroreceptor reflex do not function , changes of blood pressure are no longer adequately compensated and the heart rate is not adjusted to the current needs . The Inos2CLS pacemaker provides a system that includes the baroreceptor reflex in the regulation of the stimulation rate and the systemic blood pressure and thus reestablishes the functioning of the baroreceptor reflex . Aim of the study : Aim of the study was to prove that the baroreceptor reflex is included in the regulation of the stimulation rate by the pacemaker Inos2CLS. Furthermore , the functionality of the system under emotional and physical stress was tested . Methods : 30 patients ( 14 male , 16 female , mean age 70.9 +/- 7 years ) were implanted with the pacemaker system Inos2CLS. In order to prove the inclusion of the baroreceptor reflex in the Closed Loop Stimulation , the patients had to perform the Valsalva maneuver at the 3-month follow-up investigation . Blood pressure as well as heart rate were continually recorded by a fina-press system . Afterwards , the patients had to perform a mental stress test ( Color-Word Test ) . The physical stress was performed by a symptom-limited treadmill ergonometry . Blood pressure was recorded according to Riva/Rocci . The development of the rate as well as the differentiation between intrinsic and stimulated atrial events was recorded by the data analysis of the pacemaker . Results : All 28 patients , who were included in the investigation , showed a change in mean arterial blood pressure and heart rate which is typical for the Valsalva maneuver . In phase 1 ( rest ) the MABP was 93 +/- 13mmHg , it increased in phase 2 to 113 +/- 21mmHg , and dropped in phase 3 to 84 +/- 16mmHg . A second peak in phase 4 was at 99 +/- 12mmHg . As expected , the MABP leveled off to 94 +/- 8mmHg . At the beginning of the test , the mean rate was at 73 +/- 10bpm and increased to a maximum in phase 3 of 88 +/- 12bpm . Splitting the patients into two groups , one patients 70years , the other patients > =70years, demonstrated that blood pressure and heart rate of the older group varied less . These results reflect the reduced baroreceptor sensitivity in elderly people and can be considered as a physiological phenomenon . During the first mental phase of the Color-Word Test , blood pressure and heart rate increased by 17mmHg and 6bpm , respectively . After a two-minute rest , the test was repeated . An analogous behavior of blood pressure and heart rate could be observed . The results of the treadmill ergonometry showed for all patients an adequate development of blood pressure and heart rate , adapted to the actual situation . The exemplary development of blood pressure and heart rate of a female patient ( 53years , 172cm , 98kg , indication sicksinus syndrome ) showed that only stimulated atrial events could be observed up to the aerobic-anaerobic threshold . When stress increased , the patient's sinus node controlled the heart rate . Conclusion : This study suggests that the Closed Loop Stimulation reestablishes the baroreceptor reflex in the case of chronotropic incompetence . By simply monitoring the contraction dynamics without any further sensor systems , it may be possible to offer an optimal rate adaptation in mental and physical stress situations in the case of bradyarrhythmia combined with chronotropic incompetence . Because of the reestablishment of the baroreceptor reflex , it can be expected that the patients ' prognosis improves significantly and , leads to an increase of the patients ' \" quality of life \" ."
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] |
[] |
[] |
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{
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{
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{
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{
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{
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"arg2_id": "Herzschrittmachertherapie.00110184.eng.abstr-s27-t4",
"normalized": []
}
] |
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