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HNO.80460175.eng.abstr
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HNO.80460175.eng.abstr
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"Metastatic lesions represent 1-8% of all malignant tumors of the mouth and jaws , with rare sites of metastasis originating from different primary tumors , especially the lung and breast . The vast majority of these lesions ( up to 90% ) have been observed in the mandible and maxilla ( 5-20% ) . Another rare type of cancer that usually metastasizes to the lungs , lymph nodes , bones , liver or brain may occasionally also show spread to the paranasal sinuses . In the present paper we report our management of a 5-year-old male with renal cell carcinoma who developed metastases to the frontal and ethmoid sinuses ."
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] |
HNO.80460220.eng.abstr
|
HNO.80460220.eng.abstr
|
[
{
"id": "HNO.80460220.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Recently , the transducer and microphone of a cochlea amplifier implant ( CAI ) for the treatment of sensorineural cochlear hearing loss have been developed further for implantation into the mastoid cavity . At present , the University of Tuebingen implantable cochlea amplifier consists of an implantable microphone and an implantable piezoelectric transducer . It has been implanted into the first patients . Successful future application of this new implant depends on the suitable fit of the CAI within a patient's mastoid cavity . Using conventional X-ray and CT scans , we analyzed 50 cadaver specimens of the temporal bone before total mastoidectomy . After total mastoidectomy , the volume of the mastoid cavity was measured using CT scans and water volume determination . Finally , the CAI was implanted into those temporal bones that were large enough to house it . Our results demonstrate that the degree of pneumatization in the conventional Schueller X-ray is already a good parameter for preoperative evaluation ."
],
"offsets": [
[
0,
1027
]
]
}
] |
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]
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"cochlea"
],
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46,
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]
],
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},
{
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"CAI"
],
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"hearing"
],
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[
124,
131
]
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{
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},
{
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],
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191,
198
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]
},
{
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"hearing loss"
],
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[
124,
136
]
],
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"University"
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235
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},
{
"id": "HNO.80460220.eng.abstr-s2-t2",
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],
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261,
268
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{
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278
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{
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360
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},
{
"id": "HNO.80460220.eng.abstr-s3-t1",
"type": "umlsterm",
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[] |
[] |
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] |
HNO.80460233.eng.abstr
|
HNO.80460233.eng.abstr
|
[
{
"id": "HNO.80460233.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A comparison was made of the staining intensities of selected immunohistochemical proliferating antigens ( p53, PCNA , Ki67), DNA flow-cytometry and ultrastructures of neoplastic cells from 120 cases of laryngeal cancers . Clinically very advanced tumors were in the majority ( T3, 43% ; T4, 18% ) . A 5-grade scale was adopted to evaluate the level of immunohistochemical staining of the carcinoma cell nuclei . Positive staining was obtained in 70% for p53, 57% for Ki67 and 80% for PCNA . Sixty-two percent of the cases were DNA-diploid and 38% DNA-aneuploid . The DNA-diploid carcinomas were accompanied by enlargement of the cell nuclei , preservation of wide margins of nuclear heterochromatin , enlargements of the nuclear areas and increases in the number of nuclei . In the aneuploid-polyploid cancers the nuclei had a substantial polymorphism , with large cleaved nuclei showing significant variations in size and having a nuclear envelope . A frequent finding was euchromatization of chromatin . Dense chromatin appeared in the form of small clumps spread over the whole area of these irregular nuclei . Enlargement and activation of nucleoli were found ."
],
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{
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{
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{
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{
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{
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{
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{
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{
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]
}
] |
[] |
[] |
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HNO.80460241.eng.abstr
|
HNO.80460241.eng.abstr
|
[
{
"id": "HNO.80460241.eng.abstr-passage-0",
"type": "abstract",
"text": [
"With the aid of a mechanical middle ear model ( MMM ) the sound transmission properties of different middle ear implants were investigated . Input of the MMM involved a broad-band signal from 100 to 5000 Hz that was supplied by a miniaturized loudspeaker . Displacement of an artificial stapes footplate was measured by a fiberoptic probe . The transfer functions of four different total ossicular replacement prostheses ( TORPs ) of different materials and shapes were compared . Three of the devices revealed similar transfer functions which corresponded to the typical curve of the normal middle ear . One of the prostheses demonstrated a high-frequency deterioration of approximately 5 dB . This effect was explained by a 3- to 6-times higher mass of the implant when compared to the others . Altogether , the weight of the prosthesis seems to have the most marked impact on sound transmission to the inner ear , whereas stiffness of the implant itself is less crucial as long as it can be regarded as a rigid body ."
],
"offsets": [
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0,
1020
]
]
}
] |
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HNO.80460246.eng.abstr
|
HNO.80460246.eng.abstr
|
[
{
"id": "HNO.80460246.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Learning microsurgery of the middle ear requires preparations of temporal bones . Ethical and moral restrictions in obtaining specimens make training and research with temporal bone preparations increasingly more difficult . Due to the complex structure of the temporal bone with its communicating cavities , the manufacture of facsimiles up to now has been impossible . Rapid prototyping techniques must be able to produce identical objects from an original one . By using CT scans of temporal bones from anatomic preparations and patients we have been able to reconstruct 3D pictures on a CAD workstation . We are now able to incorporate data in a stereolithographic system to create an anatomic facsimile of the temporal bone . It is possible to produce a considerable number of these facsimiles from the same real object . With this method we can produce models of human structure for medical teaching , training and research . Our artificial preparations of temporal bones correspond to both the material characteristics and anatomic details of human structures , allowing various surgical exercises to be carried out ."
],
"offsets": [
[
0,
1124
]
]
}
] |
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[] |
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HNO.80460252.eng.abstr
|
HNO.80460252.eng.abstr
|
[
{
"id": "HNO.80460252.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The present study sought to determine the etiology of bilateral profound hearing losses in children living in Germany . Additionally , a comparison with the data of previous investigations in the available literature was used to update causes now known through medical progress . Patients and methods : The medical charts of 314 profoundly hearing-impaired pupils at schools for the deaf in Cologne , Germany , were reviewed . All available data on possible etiological factors were collected . In addition , the families of these children were interviewed using a standardized questionnaire . Results : Sixty children were found to have bilateral sensorineural hearing losses averaging 30 to 60 dBHL within the frequency ranges of 500-2000 HZ , while 254 had bi- lateral hearing impairments of 60 dBHL or greater . The etiology of the hearing disorder could be determined in 218 of the children . Eighty-two children suffered from hereditary deafness and 136 from acquired hearing losses . The etiology could not be determined in 96 children . Hereditary causes included 34 children with mendelian autosomal dominant losses , 46 with autosomal recessive losses and two children with genetic but non-mendelian causes . Immigrants to Germany ( mostly from Turkey and the former Soviet Union ) were found significantly more frequently among the students of these schools than among the total population of the Cologne area . In this group of students , autosomal recessive deafness was particularly common as compared to the overall native population . Acquired hearing disorders were broken down into three subgroups : prenatal , perinatal and postnatal disorders . A prenatal etiology was considered in 32 children , 21 of whom had known congenital rubella infection . This entity was significantly less common among younger children . A perinatal etiology was considered in 60 children . Causative factors were birth asphyxia , apnea and/or hyperbilirubinemia . Forty-four children had deafness attributed to postnatal causes , with bacterial meningitis ( n=31) being the most important single factor . The findings reported indicate changing trends for causes of hearing loss in children with severe hearing impairment in Germany ."
],
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0,
2233
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}
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HNO.80460266.eng.abstr
|
HNO.80460266.eng.abstr
|
[
{
"id": "HNO.80460266.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Laryngeal candidiasis is very rare in the absence of other more proximal diseases in the aerodigestive tract . The lesion shows pseudoepitheliomatous hyperplasia or acanthosis and , given its rarity , may be confused with cancer . In the present paper we report on a 56-year-old male patient who presented with hoarseness . Physical examination of the larynx revealed a hyperplastic lesion involving both vocal cords . The clinical aspect and the risk factor profile of the patient ( ten bottles of beer and 40 cigarettes per day ) generated the clinical diagnosis of laryngeal cancer . A biopsy was taken . The histopathological examination of the specimen excluded a squamous cell carcinoma ; however , it could not provide a clear diagnosis . Laryngeal papillomatosis and tuberculosis , which had been suspected , could be excluded . As the lesion progressed , further biopsies led to the diagnosis of candidiasis . Systemic antimycotic treatment with fluconazol and amphotericin caused a complete remission ."
],
"offsets": [
[
0,
1012
]
]
}
] |
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352,
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]
},
{
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{
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[] |
[] |
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HNO.80460270.eng.abstr
|
HNO.80460270.eng.abstr
|
[
{
"id": "HNO.80460270.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Processes in the middle ear can occasionally lead to clinical disorders extending beyond the anatomic boundaries of the area of the mastoid process . In contrast to this , pathological processes of the areas adjoining the middle ear might also lead to secondary involvement of the tympanic area . The report describes an initially asymptomatic epidural hematoma , which secondarily led to involvement of the middle ear . In general , such cases affecting the middle ear will produce symptoms usually interpreted as primary middle ear pathology . This association shows which disorders must be considered , the differential diagnosis and methods of therapy ."
],
"offsets": [
[
0,
657
]
]
}
] |
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{
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{
"id": "HNO.80460270.eng.abstr-s3-t1",
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{
"id": "HNO.80460270.eng.abstr-s3-t3",
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[] |
[] |
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"id": "HNO.80460270.eng.abstr-s5-r23-t3.2-t2.1",
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"id": "HNO.80460270.eng.abstr-s5-r24-t4.2-t5.1",
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}
] |
HNO.80460303.eng.abstr
|
HNO.80460303.eng.abstr
|
[
{
"id": "HNO.80460303.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Speculations concerning a possible association between temporomandibular disorders ( TMDs ) and ear symptoms of otalgia and tinnitus have been made in the dental and medical literature for a long time . Current understanding of this association is reviewed . An analysis of relevant studies published between 1947 and 1996 shows that a relatively high percentage of TMD patients reported the presence of ear pain and noise . However , a cause-effect relationship has not been established to date . Theories that try to explain the concurrence of TMD symptoms and ear symptoms ( particularly tinnitus ) by a common underlying cause remain speculative . It has to be taken into consideration that due to their high prevalence , TMDs and ear symptoms in a given patient may be present by chance alone . A methodological weakness of most of the studies available is the fact that control groups were not considered . Owing to the lack of prospective , controlled , and randomized studies , statements regarding the effectiveness of certain dental measures for the treatment of otalgia and tinnitus in TMD patients are not well supported ."
],
"offsets": [
[
0,
1134
]
]
}
] |
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{
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"type": "umlsterm",
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"disorders"
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73,
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{
"id": "HNO.80460303.eng.abstr-s1-t3",
"type": "umlsterm",
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"ear"
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"symptoms"
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100,
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"id": "HNO.80460303.eng.abstr-s1-t5",
"type": "umlsterm",
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"otalgia"
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112,
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"tinnitus"
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124,
132
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"temporomandibular disorders"
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"understanding"
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"pain"
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"noise"
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"id": "HNO.80460303.eng.abstr-s3-t6",
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"ear pain"
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"ear"
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{
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"tinnitus"
],
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591,
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"cause"
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{
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"prevalence"
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"weakness"
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]
},
{
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"control"
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}
]
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{
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"type": "umlsterm",
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"control groups"
],
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"type": "umlsterm",
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"measures"
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}
]
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{
"id": "HNO.80460303.eng.abstr-s8-t2",
"type": "umlsterm",
"text": [
"treatment"
],
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1060,
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}
]
},
{
"id": "HNO.80460303.eng.abstr-s8-t3",
"type": "umlsterm",
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"otalgia"
],
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1073,
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]
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}
]
},
{
"id": "HNO.80460303.eng.abstr-s8-t4",
"type": "umlsterm",
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"tinnitus"
],
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[
1085,
1093
]
],
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}
]
},
{
"id": "HNO.80460303.eng.abstr-s8-t5",
"type": "umlsterm",
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"patients"
],
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[
1101,
1109
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0030705"
}
]
}
] |
[] |
[] |
[
{
"id": "HNO.80460303.eng.abstr-s1-r1-t2.1-t6.1",
"type": "associated_with",
"arg1_id": "HNO.80460303.eng.abstr-s8-t2",
"arg2_id": "HNO.80460303.eng.abstr-s3-t6",
"normalized": []
},
{
"id": "HNO.80460303.eng.abstr-s1-r2-t9.1-t4.1",
"type": "associated_with",
"arg1_id": "HNO.80460303.eng.abstr-s1-t9",
"arg2_id": "HNO.80460303.eng.abstr-s8-t4",
"normalized": []
},
{
"id": "HNO.80460303.eng.abstr-s1-r3-t1.1-t9.1",
"type": "result_of",
"arg1_id": "HNO.80460303.eng.abstr-s8-t1",
"arg2_id": "HNO.80460303.eng.abstr-s1-t9",
"normalized": []
},
{
"id": "HNO.80460303.eng.abstr-s1-r4-t2.1-t4.1",
"type": "associated_with",
"arg1_id": "HNO.80460303.eng.abstr-s8-t2",
"arg2_id": "HNO.80460303.eng.abstr-s8-t4",
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},
{
"id": "HNO.80460303.eng.abstr-s1-r5-t3.1-t2.1",
"type": "location_of",
"arg1_id": "HNO.80460303.eng.abstr-s8-t3",
"arg2_id": "HNO.80460303.eng.abstr-s8-t2",
"normalized": []
},
{
"id": "HNO.80460303.eng.abstr-s1-r6-t8.1-t1.1",
"type": "result_of",
"arg1_id": "HNO.80460303.eng.abstr-s1-t8",
"arg2_id": "HNO.80460303.eng.abstr-s8-t1",
"normalized": []
},
{
"id": "HNO.80460303.eng.abstr-s1-r7-t2.1-t1.1",
"type": "result_of",
"arg1_id": "HNO.80460303.eng.abstr-s8-t2",
"arg2_id": "HNO.80460303.eng.abstr-s8-t1",
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},
{
"id": "HNO.80460303.eng.abstr-s1-r8-t1.1-t8.1",
"type": "occurs_in",
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},
{
"id": "HNO.80460303.eng.abstr-s1-r9-t9.1-t1.1",
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},
{
"id": "HNO.80460303.eng.abstr-s1-r10-t1.1-t2.1",
"type": "result_of",
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"normalized": []
},
{
"id": "HNO.80460303.eng.abstr-s1-r11-t3.1-t1.1",
"type": "location_of",
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},
{
"id": "HNO.80460303.eng.abstr-s1-r12-t3.1-t9.1",
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},
{
"id": "HNO.80460303.eng.abstr-s1-r13-t9.1-t6.1",
"type": "associated_with",
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"arg2_id": "HNO.80460303.eng.abstr-s3-t6",
"normalized": []
},
{
"id": "HNO.80460303.eng.abstr-s6-r1-t3.1-t1.1",
"type": "uses",
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"arg2_id": "HNO.80460303.eng.abstr-s8-t1",
"normalized": []
},
{
"id": "HNO.80460303.eng.abstr-s8-r1-t1.1-t4.1",
"type": "treats",
"arg1_id": "HNO.80460303.eng.abstr-s8-t1",
"arg2_id": "HNO.80460303.eng.abstr-s8-t4",
"normalized": []
},
{
"id": "HNO.80460303.eng.abstr-s8-r2-t2.1-t4.1",
"type": "treats",
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"arg2_id": "HNO.80460303.eng.abstr-s8-t4",
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},
{
"id": "HNO.80460303.eng.abstr-s8-r3-t2.1-t1.1",
"type": "treats",
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},
{
"id": "HNO.80460303.eng.abstr-s8-r4-t1.1-t5.1",
"type": "affects",
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},
{
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{
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"type": "performs",
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},
{
"id": "HNO.80460303.eng.abstr-s8-r7-t2.1-t5.1",
"type": "affects",
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},
{
"id": "HNO.80460303.eng.abstr-s8-r8-t5.1-t1.1",
"type": "performs",
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"arg2_id": "HNO.80460303.eng.abstr-s8-t1",
"normalized": []
}
] |
HNO.80460311.eng.abstr
|
HNO.80460311.eng.abstr
|
[
{
"id": "HNO.80460311.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The first electronic implantable hearing aids for patients with hearing loss are coupled to the ossicular chain or perilymph during implantation and are now available . Our new Tuebingen implant designed for sensorineural hearing loss ( SNHL ) is the combination of an implantable microphone and piezotransducer . To avoid hearing losses during implantation , the Tuebingen piezotransducer will be ( 1 ) fixed to the mastoid cavity and ( 2 ) positioned to one of the ossicular target points . This can be done with a micromanipulator which will be implanted together with transducer and microphone in the mastoid cavity . The manipulator weights 0.7 g . With four degrees of freedom , it allows highly secure and safe positioning of the transducer's probe tip to the ossicular chain under close to stereotactic conditions . The main advantages of the present micromanipulator are ( 1 ) easy handling during surgery , ( 2 ) the transducer's precise positioning to the ossicular target point with sufficient degrees of freedom , and ( 3 ) the transducer's stable fixation in the mastoid cavity in the final position . Following integrated safety as the leading principle , ossicular or inner ear injuries caused , e.g. , by the patient's head movement or unintentional manual contact by the surgeon , are minimized . The micromanipulator is , as it were , the surgeon's vibration-free \" artificial hand \" . The manipulator's development and its optimization to the mastoid cavity by test implantation in 50 human temporal bones are shown in detail . While coupling the transducer to the body of the incus , transducer , microphone , and micromanipulator can be implanted into 76% of all mastoid cavities without protrusion . In the case of transducers coupling to the long process of the incus , the protrusion-free implantation rate of the above-mentioned three implant modules is 78% ."
],
"offsets": [
[
0,
1885
]
]
}
] |
[
{
"id": "HNO.80460311.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"electronic"
],
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[
10,
20
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0013850"
}
]
},
{
"id": "HNO.80460311.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"hearing"
],
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[
33,
40
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0018767"
}
]
},
{
"id": "HNO.80460311.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"aids"
],
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[
41,
45
]
],
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{
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"db_id": "C0021588"
},
{
"db_name": "UMLS",
"db_id": "C0001175"
}
]
},
{
"id": "HNO.80460311.eng.abstr-s1-t4",
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] |
[] |
[] |
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HNO.80460324.eng.abstr
|
HNO.80460324.eng.abstr
|
[
{
"id": "HNO.80460324.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Within the battery of functional tests used in patients considered to have an acoustic neuroma , the use of vestibular examination has been reduced by the widespread use of magnetic resonance imaging . Especially small tumors often show normal or atypical results in electronystagmographic examinations ( ENG ) . The purpose of the present study was to determine the diagnostic value of preoperative vestibular diagnosis in predicting the origin of an acoustic neuroma , as well as the duration of postoperative vestibular compensation and facial nerve function . Sixty-seven patients with intraoperatively confirmed tumor origins were examined preoperatively by ENG and electroneurography in addition to careful clinical examination . Group 1 ( n=45) consisted of patients with tumor originating from the inferior vestibular nerve and group 2 ( n=22) had tumor involving the superior vestibular nerve . Postoperatively , facial nerve function was determined by using the House grading system and vestibular function was defined by ENG 3 , 6 and 12 months after surgery . Forty-seven percent of the patients in group 1 showed a pathologic caloric response compared to 64% in group 2. When patients had only a small tumor ( 1 cm ) , 27% of the patients in group 1 and 71% in group 2 had abnormal caloric results . Vestibular recovery was prolonged in group 1 , but a statistically significant difference in postoperative facial nerve function could not be found . These findings confirm that especially small tumors arising from the inferior vestibular nerve can remain undetected by using ENG for diagnosis ."
],
"offsets": [
[
0,
1608
]
]
}
] |
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[] |
[] |
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HNO.80460339.eng.abstr
|
HNO.80460339.eng.abstr
|
[
{
"id": "HNO.80460339.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The German Registry for Hearing Loss in Children ( DZH ) processes nationwide data from audiological centers . Coping with the accrued data and its subsequent management and analysis requires a high degree of security and control . To establish a nationwide registry it is necessary at an early stage to take into consideration the legal requirements of the participating states . Use of the DZH as an example demonstrates how a pragmatic solution can be reached . Special issues concerning data collection , transfer , storage and deletion , coding strategies to ensure anonymity , checking for duplicate entries , data separation , and automated data analysis and data protection are explained ."
],
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[
0,
697
]
]
}
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40,
48
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666,
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}
] |
[] |
[] |
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HNO.80460348.eng.abstr
|
HNO.80460348.eng.abstr
|
[
{
"id": "HNO.80460348.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The simulation of unilateral deafness is very rare . Objective findings are of special interest if it happens . A patient with alleged deafness on the left-hand side due to commotio cerebri was treated in our hospital . Pure tone audiometry showed deafness on the left-hand side and normal hearing on the right-hand side . However , stapedius reflexes were found ipsilaterally left as well as contralaterally right , at 0.5 to 2 kHz with a stimulation of approxamately 90 dB SPL . Transiently evoked otoacoustic emissions ( TEOAE ) and distortion-product otoacoustic emissions ( DPOAE ) were measured . The TEOAE had the same reproducibility but a very low response on both sides , such that inner ear function could not be evaluated . In comparison , the DP gram showed clear DP amplitudes over the whole frequency range on both sides . Nonphysiological DPs could be excluded by assessing the DP growth rate at three different frequencies . By means of brainstem electric response audiometry ( BERA ) , with which the IV/V complex was detectable up to stimulation with 20 dB SPL clicks , and the Stenger test , a neural or central hearing loss could be excluded . Normal hearing on the left-hand side was thus confirmed . In cases of simulated deafness it is possible to prove a normal inner ear function by DPOAE . DPOAE therefore complements the list of potential audiological simulation tests ."
],
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[
0,
1398
]
]
}
] |
[
{
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"deafness"
],
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[
29,
37
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] |
[] |
[] |
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HNO.80460354.eng.abstr
|
HNO.80460354.eng.abstr
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{
"id": "HNO.80460354.eng.abstr-passage-0",
"type": "abstract",
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"Actinomycosis is currently an uncommonly diagnosed human disease . However , it can still complicate trauma to the respiratory and digestive tracts , including operative procedures . A patient with cervicofacial actinomycosis commonly gives a history of recent dental manipulation which usually , involves extraction of a mandibular molar . The common initial symptoms of infection - such as , sudden onset of cervicofacial pain , swelling , erythema , edema and suppuration - can be absent . Infection due to actinomyces is a well-known mimic of malignancy is clinical , radiological and pathological findings . In the case described a 65-year-old man had a mass in his right parotid area . Because of its painless rapid growth with infiltration of the mandible as demonstrated by clinical findings and CT and MRI scans , we established an initial diagnosis of salivary gland malignancy . Salivary gland biopsy then revealed a histological picture of infection due to actinomyces . Therapy was initiated with intravenous amoxicillin and sulbactam . After 20 days of treatment diseased soft tissues and bone were resected . To prevent a relapse the patient received oral clindamycin for 6 weeks . After a followup of two years , the patient has remained free of disease ."
],
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] |
[] |
[] |
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HNO.80460494.eng.abstr
|
HNO.80460494.eng.abstr
|
[
{
"id": "HNO.80460494.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The epithelial pathogenesis of acquired cholesteatoma has been widely accepted , but clinical and experimental data have not been able to answer questions like : How does a cholesteatoma start or grow or how is bone resorption of conducted ? From our own experiments and literature a new hypothesis of cholesteatoma origin and growth is drawn . Three prerequisites are necessary for development : ( 1 ) the unique anatomical situation at the ear-drum ( two different epithelial layers close together ) ; ( 2 ) chronic destruction of the submucosal tissue in the middle ear ( infection , inflammation ) ; ( 3 ) wound healing ( proliferation phase ) . Destruction of the submucosal space by middle ear infection and cell necrosis starts the wound healing cascade . In wound healing generally the connective tissue fibroblasts and macrophages play a pivotal role . Cyto- kines of the wound healing thought to promote the re-epithelization of the mucosal defect and scar tissue development act upon the intact squamous cell layer of the outer surface of the ear-drum at the same time . Thereby a proliferation of the undamaged epithelial layer is induced . Cholesteatoma matrix is always surrounded by a layer of connective tissue , the perimatrix . Persistence of the inflammation causes permanent wound healing in the perimatrix , proliferation of the fibroblasts ( granulation tissue ) and proliferation of the epithelium ( matrix ) . It is speculated that by virtue of wound healing cytokines of fibroblasts and macrophages are the driving forces of cholesteatoma origin , growth and bone destruction ."
],
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0,
1602
]
]
}
] |
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] |
[] |
[] |
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HNO.80460502.eng.abstr
|
HNO.80460502.eng.abstr
|
[
{
"id": "HNO.80460502.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The vomeronasal organ , or Jacobson's organ , is essential for pheromone detection and reproductive behavior in most mammals . In humans , it has been described as a blind diverticulum in the anterior nasal septum , but without a documented function . The purpose of this study is to describe the fine structure of the human adult vomeronasal organ in 14 specimens . Our studies showed a duct-like invagination of the epithelium that was surrounded by numerous exocrine glands with short ducts . The fine structure of these glands suggested a serous secretion . In the depth of the invagination , pseudostratified columnar epithelial cells were seen that had plump processes , kinocilia and microvilli at the apical cell membrane . Several cell types were seen that differed regarding their organelles and electron density , with light sensory cells exhibiting neurofilaments . Underneath the typical basement membrane , numerous myelinated and unmyelinated axons were present in the very vascular lamina proprion . These morphological findings are unique in the human body and suggest that a chemosensory epithelium corresponding to a vomeronasal organ may exist . Its central connections and the possible functional significance of this tubed organ for pheromone detection are unknown and need further study ."
],
"offsets": [
[
0,
1311
]
]
}
] |
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HNO.80460513.eng.abstr
|
HNO.80460513.eng.abstr
|
[
{
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"type": "abstract",
"text": [
"In contrast to auditory brainstem potentials ( ABR ) , a more apically defined generation of middle latency evoked potentials ( MLR ) can be assumed due to the longer integration time present . To date , the effect of stimulus frequency spectra on MLR has not been completely known . By using masking with high-pass filtered white noise in 12 normal-hearing adults , we measured the dependence of amplitude and latency of ABR and MLR on filter frequency . No differences were found between the masking effects for ABR and MLR evoked by tone bursts of 0.5 and 2 kHz . The high-pass masking of click stimuli showed a greater influence on the amplitude and latency of the ABR than on MLR . These different qualities have to be considered clinically when evaluating the methods and results of hearing testing with acoustic evoked potentials . Our findings show that MLR evoked by tone bursts should be used for the frequency selective diagnosis of hearing thresholds , especially in low- frequency ranges ."
],
"offsets": [
[
0,
1002
]
]
}
] |
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] |
[] |
[] |
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] |
HNO.80460519.eng.abstr
|
HNO.80460519.eng.abstr
|
[
{
"id": "HNO.80460519.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Elevation of nasal resistance has been described as an effect of increased air temperature by different authors . The aim of this study was to evaluate the effect of high environmental temperature on congestion of the nasal mucosa . In all , 102 volunteers were studied and included normal controls , heart rehabilitation patients and high performance sportsmen . Rhinomanometric examinations were carried out before and after 10 min in a dry Finnish sauna at a 90 °C temperature . Computerized active anterior rhinomanometry was used . A uniform response pattern to the increased temperature could not be observed : i.e. , some individuals had an elevated resistance immediately after the sauna while resistance was decreased in others . The relationship between the reaction of the nasal mucosa to body work and temperature is discussed ."
],
"offsets": [
[
0,
840
]
]
}
] |
[
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78
]
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},
{
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"temperature"
],
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79,
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]
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},
{
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}
]
},
{
"id": "HNO.80460519.eng.abstr-s2-t1",
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"aim"
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}
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},
{
"id": "HNO.80460519.eng.abstr-s2-t2",
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"temperature"
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185,
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]
},
{
"id": "HNO.80460519.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"mucosa"
],
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[
224,
230
]
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]
},
{
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],
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218,
230
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{
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{
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]
},
{
"id": "HNO.80460519.eng.abstr-s3-t3",
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"text": [
"heart"
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[
301,
306
]
],
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}
]
},
{
"id": "HNO.80460519.eng.abstr-s3-t4",
"type": "umlsterm",
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"rehabilitation"
],
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[
307,
321
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},
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}
]
},
{
"id": "HNO.80460519.eng.abstr-s3-t5",
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]
},
{
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]
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}
]
},
{
"id": "HNO.80460519.eng.abstr-s4-t2",
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"sauna"
],
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[
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},
{
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],
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468,
479
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],
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}
]
},
{
"id": "HNO.80460519.eng.abstr-s5-t1",
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],
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]
},
{
"id": "HNO.80460519.eng.abstr-s5-t2",
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],
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511,
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]
],
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]
},
{
"id": "HNO.80460519.eng.abstr-s6-t1",
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] |
[] |
[] |
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] |
HNO.80460524.eng.abstr
|
HNO.80460524.eng.abstr
|
[
{
"id": "HNO.80460524.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Cochlear implantation has evolved from its experimental state into a safe and effective therapy for the treatment of profound deafness . Although not applicable to all patients , it offers an alternative to a life in silence . In particular , in early detected and treated deafness in childhood inner ear prostheses have enabled affected persons to be integrated into the world of sound . In addition to the significant impact that therapy has on the life of the individual , there is a social and cultural consequence for society . This is epitomized in the criticism by the deaf community that has resulted in the total rejection of cochlear implants . A critical analysis reveals different personal images prevailing in the deaf community . Knowledge of these differences and their relevance is important for all clinicians involved in counselling a cochlear implant candidate ."
],
"offsets": [
[
0,
881
]
]
}
] |
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}
] |
[] |
[] |
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HNO.80460529.eng.abstr
|
HNO.80460529.eng.abstr
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"Acoustic rhinometry is a unique non-invasive technique for imaging and measuring the free cross-sectional area of the main nasal cavity . By so doing , reactions of the mucosa can be assessed at any selected site in the nose . The goal of this study was to define the optimal conditions for the utilization of acoustic rhinometry to determine the ability of an antihistamine to alter the effects of histamine in the mucous membrane of the nose . In a group of 30 healthy volunteers subjectively normal nasal breathing , and no history of allergy , rhinometry was performed to measure the cross-sectional area in the region of the head of the inferior nasal concha at 0.5 , 10 and 15 min after histamine provocation . The volunteers subsequently received cetirizine as antihistamine . Four hours later , rhinometry was repeated after adminis-tration of histamine via the contralateral nostril . Findings showed that conchal dilatation measured 10 min after provocation was statistically less severe in 63.3% of the patients treated with cetirizine . Compared to pretreatment values , the ventilated cross-sectional area became 45.6% larger after administration antihistamine . These findings demonstrated that the nasal swelling measured 10 min after antihistamine administration was due to the effects of histamine and was not due to tactile or physical stimuli . Thepresent studies showed that the new measurement technique is precise and reproducible . These results have also demonstrated that a acoustic rhinometry permits an objective assessment of drug efficacy while making it possible to avoid the errors observed in other variable regions of the nose , such as the nasal isthmus or nasopharynx as well as errors associated with subjective scoring systems ."
],
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] |
[] |
[] |
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] |
HNO.80460542.eng.abstr
|
HNO.80460542.eng.abstr
|
[
{
"id": "HNO.80460542.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The clinical features of progression sensorineural hearing loss and vertigo in combina-tion with the radiologic finding of a contrast- enhancing mass within the inner auditory canal are suggestive of an acoustic neuroma . We report our findings in a 57-year-old woman with known mixed connective tissue disease who was presumed to have a neuroma . A large malignant lymphoma of the cerebellopontine angle presented clinically with a primary acoustic none palsy and no other central neurological deficits . Both the primary radiological examinations and the exclusively peripheral nerve palsy failed to indicate manifestationes of a lymphoma . The development of a progressive facial palsy within 8 weeks of presentation and an atypi-cal occipital headache were uncommon findings for an acoustic neuroma . Such changes in symptoms despite the occurrence of car-dinal symptoms require further diagnostic measures . Manifestations of a malignant lymphoma in the cerebellopontine angle are extremely rare . To our knowledge a case of an intracerebral lymphoma in a patient with Sjoegren's syndrome has never been reported before ."
],
"offsets": [
[
0,
1126
]
]
}
] |
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] |
[] |
[] |
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] |
HNO.80460548.eng.abstr
|
HNO.80460548.eng.abstr
|
[
{
"id": "HNO.80460548.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A case of tracheal cyst is described in a 43-year-old man who was admitted with nonspecific symptoms of an obstruction in the upper respiratory tract . A CT scan of the thorax showed a solid tumor on the inner tracheal wall . Bronchoscopy revealed a tumor with a borad base and smooth surface that almost completely obstructed the trachea . Intraoperatively , the tumor was found to be a cyst and was successfully removed endoscopically . Tracheal cysts are quite rare and most of the reported cases have been confined to pediatric patients as a congenital disease . More frequently , congenital intraluminal cysts of the upper respiratory tract are found as epiglottic retention cysts and laryngoceles ."
],
"offsets": [
[
0,
704
]
]
}
] |
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{
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{
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{
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] |
HNO.80460569.eng.abstr
|
HNO.80460569.eng.abstr
|
[
{
"id": "HNO.80460569.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The prosthetic rehabilitation of cranio-facial defects and malformations has made enormous progress with the development of currently available silicones and the discovery of titanium as an optimally bicompatible implant material . This allows for a reliable , solid fixation of cranio-facial prostheses , which , due to modern production techniques , give outstanding camouflage to defects . To reconstruct such complex aesthetic entities as the ear , nose and orbit , bone-anchored prostheses now represent more than just an alternative to plastic surgery . Their removal also allows early recognition of recurrences following tumor surgery . The principles of implantology and all commercially available systems are presented , as well as indications , contraindications and our personal experience with 120 patients who received bone-anchored prostheses at the ENT Department of the University of Saarland in Homburg , Germany ."
],
"offsets": [
[
0,
932
]
]
}
] |
[
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]
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},
{
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54
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{
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[] |
[] |
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},
{
"id": "HNO.80460569.eng.abstr-s4-r8-t4.2-t4.1",
"type": "issue_in",
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},
{
"id": "HNO.80460569.eng.abstr-s4-r9-t3.1-t2.1",
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},
{
"id": "HNO.80460569.eng.abstr-s4-r10-t2.1-t1.1",
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{
"id": "HNO.80460569.eng.abstr-s4-r11-t3.1-t1.1",
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},
{
"id": "HNO.80460569.eng.abstr-s5-r1-t3.1-t1.1",
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},
{
"id": "HNO.80460569.eng.abstr-s5-r2-t1.1-t3.1",
"type": "performs",
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"arg2_id": "HNO.80460569.eng.abstr-s5-t3",
"normalized": []
},
{
"id": "HNO.80460569.eng.abstr-s5-r3-t1.1-t3.1",
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},
{
"id": "HNO.80460569.eng.abstr-s5-r4-t1.1-t3.2",
"type": "uses",
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"arg2_id": "HNO.80460569.eng.abstr-s5-t3",
"normalized": []
}
] |
HNO.80460579.eng.abstr
|
HNO.80460579.eng.abstr
|
[
{
"id": "HNO.80460579.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The long-term and successful treatment of facial defects with bone-anchored prostheses requires daily cleaning of the prosthesis , any retention elements and surrounding skin . This keeps a potential problem zone around the implant healthy and free of inflammation . Suitable concepts for care and cleaning aids are discussed ."
],
"offsets": [
[
0,
327
]
]
}
] |
[
{
"id": "HNO.80460579.eng.abstr-s1-t1",
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"treatment"
],
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[
29,
38
]
],
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"db_id": "C0087111"
},
{
"db_name": "UMLS",
"db_id": "C0039798"
}
]
},
{
"id": "HNO.80460579.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"defects"
],
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[
49,
56
]
],
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{
"db_name": "UMLS",
"db_id": "C0243067"
}
]
},
{
"id": "HNO.80460579.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"prostheses"
],
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[
76,
86
]
],
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{
"db_name": "UMLS",
"db_id": "C0525024"
},
{
"db_name": "UMLS",
"db_id": "C0175649"
}
]
},
{
"id": "HNO.80460579.eng.abstr-s1-t4",
"type": "umlsterm",
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"prosthesis"
],
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[
118,
128
]
],
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{
"db_name": "UMLS",
"db_id": "C0525024"
},
{
"db_name": "UMLS",
"db_id": "C0175649"
}
]
},
{
"id": "HNO.80460579.eng.abstr-s1-t5",
"type": "umlsterm",
"text": [
"retention"
],
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[
135,
144
]
],
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{
"db_name": "UMLS",
"db_id": "C0080274"
},
{
"db_name": "UMLS",
"db_id": "C0035280"
}
]
},
{
"id": "HNO.80460579.eng.abstr-s1-t6",
"type": "umlsterm",
"text": [
"elements"
],
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[
145,
153
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0013879"
}
]
},
{
"id": "HNO.80460579.eng.abstr-s1-t7",
"type": "umlsterm",
"text": [
"skin"
],
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[
170,
174
]
],
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{
"db_name": "UMLS",
"db_id": "C0037267"
}
]
},
{
"id": "HNO.80460579.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"inflammation"
],
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[
252,
264
]
],
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{
"db_name": "UMLS",
"db_id": "C0021368"
}
]
},
{
"id": "HNO.80460579.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"care"
],
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[
289,
293
]
],
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{
"db_name": "UMLS",
"db_id": "C0150499"
}
]
},
{
"id": "HNO.80460579.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"aids"
],
"offsets": [
[
307,
311
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0021588"
},
{
"db_name": "UMLS",
"db_id": "C0001175"
}
]
}
] |
[] |
[] |
[
{
"id": "HNO.80460579.eng.abstr-s1-r1-t6.1-t4.2",
"type": "affects",
"arg1_id": "HNO.80460579.eng.abstr-s1-t6",
"arg2_id": "HNO.80460579.eng.abstr-s1-t4",
"normalized": []
},
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"id": "HNO.80460579.eng.abstr-s1-r2-t7.1-t5.2",
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},
{
"id": "HNO.80460579.eng.abstr-s1-r4-t4.2-t7.1",
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"arg2_id": "HNO.80460579.eng.abstr-s1-t7",
"normalized": []
},
{
"id": "HNO.80460579.eng.abstr-s1-r5-t7.1-t1.1",
"type": "isa",
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},
{
"id": "HNO.80460579.eng.abstr-s1-r6-t4.2-t5.2",
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},
{
"id": "HNO.80460579.eng.abstr-s1-r7-t7.1-t5.2",
"type": "result_of",
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"normalized": []
},
{
"id": "HNO.80460579.eng.abstr-s1-r8-t5.2-t4.2",
"type": "result_of",
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"normalized": []
},
{
"id": "HNO.80460579.eng.abstr-s1-r9-t7.1-t5.2",
"type": "location_of",
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"normalized": []
},
{
"id": "HNO.80460579.eng.abstr-s1-r10-t7.1-t1.1",
"type": "location_of",
"arg1_id": "HNO.80460579.eng.abstr-s1-t7",
"arg2_id": "HNO.80460579.eng.abstr-s3-t1",
"normalized": []
},
{
"id": "HNO.80460579.eng.abstr-s1-r11-t4.2-t1.1",
"type": "associated_with",
"arg1_id": "HNO.80460579.eng.abstr-s1-t4",
"arg2_id": "HNO.80460579.eng.abstr-s3-t1",
"normalized": []
},
{
"id": "HNO.80460579.eng.abstr-s1-r12-t5.2-t7.1",
"type": "affects",
"arg1_id": "HNO.80460579.eng.abstr-s1-t5",
"arg2_id": "HNO.80460579.eng.abstr-s1-t7",
"normalized": []
},
{
"id": "HNO.80460579.eng.abstr-s1-r13-t7.1-t4.2",
"type": "location_of",
"arg1_id": "HNO.80460579.eng.abstr-s1-t7",
"arg2_id": "HNO.80460579.eng.abstr-s1-t4",
"normalized": []
},
{
"id": "HNO.80460579.eng.abstr-s1-r14-t7.1-t3.2",
"type": "location_of",
"arg1_id": "HNO.80460579.eng.abstr-s1-t7",
"arg2_id": "HNO.80460579.eng.abstr-s1-t3",
"normalized": []
},
{
"id": "HNO.80460579.eng.abstr-s1-r15-t7.1-t1.2",
"type": "isa",
"arg1_id": "HNO.80460579.eng.abstr-s1-t7",
"arg2_id": "HNO.80460579.eng.abstr-s1-t1",
"normalized": []
},
{
"id": "HNO.80460579.eng.abstr-s1-r16-t6.1-t5.2",
"type": "affects",
"arg1_id": "HNO.80460579.eng.abstr-s1-t6",
"arg2_id": "HNO.80460579.eng.abstr-s1-t5",
"normalized": []
},
{
"id": "HNO.80460579.eng.abstr-s1-r17-t7.1-t2.1",
"type": "isa",
"arg1_id": "HNO.80460579.eng.abstr-s1-t7",
"arg2_id": "HNO.80460579.eng.abstr-s3-t2",
"normalized": []
},
{
"id": "HNO.80460579.eng.abstr-s1-r18-t7.1-t4.2",
"type": "associated_with",
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"arg2_id": "HNO.80460579.eng.abstr-s1-t4",
"normalized": []
},
{
"id": "HNO.80460579.eng.abstr-s1-r19-t4.2-t5.2",
"type": "result_of",
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"arg2_id": "HNO.80460579.eng.abstr-s1-t5",
"normalized": []
},
{
"id": "HNO.80460579.eng.abstr-s1-r20-t4.2-t7.1",
"type": "associated_with",
"arg1_id": "HNO.80460579.eng.abstr-s1-t4",
"arg2_id": "HNO.80460579.eng.abstr-s1-t7",
"normalized": []
},
{
"id": "HNO.80460579.eng.abstr-s3-r1-t2.2-t1.1",
"type": "associated_with",
"arg1_id": "HNO.80460579.eng.abstr-s3-t2",
"arg2_id": "HNO.80460579.eng.abstr-s3-t1",
"normalized": []
},
{
"id": "HNO.80460579.eng.abstr-s3-r2-t1.1-t2.2",
"type": "associated_with",
"arg1_id": "HNO.80460579.eng.abstr-s3-t1",
"arg2_id": "HNO.80460579.eng.abstr-s3-t2",
"normalized": []
},
{
"id": "HNO.80460579.eng.abstr-s3-r3-t2.2-t1.1",
"type": "result_of",
"arg1_id": "HNO.80460579.eng.abstr-s3-t2",
"arg2_id": "HNO.80460579.eng.abstr-s3-t1",
"normalized": []
}
] |
HNO.80460587.eng.abstr
|
HNO.80460587.eng.abstr
|
[
{
"id": "HNO.80460587.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Introduction : In recent studies we identified two morphological phenomena in the facial nucleus of the brainstem that play an important role in the recovery of facial movement : hyperinnervation and misdirected reinnervation . While the hyperinnervation could easily be quantified by cell counting , the extent of misdirected reinnervation could not be estimated accurately . In the present study we developed a method for accurate quantification of this misdirected reinnervation ."
],
"offsets": [
[
0,
483
]
]
}
] |
[
{
"id": "HNO.80460587.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"morphological"
],
"offsets": [
[
51,
64
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0543482"
}
]
},
{
"id": "HNO.80460587.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"nucleus"
],
"offsets": [
[
89,
96
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0007610"
}
]
},
{
"id": "HNO.80460587.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"brainstem"
],
"offsets": [
[
104,
113
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0006121"
}
]
},
{
"id": "HNO.80460587.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"role"
],
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[
137,
141
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0035820"
}
]
},
{
"id": "HNO.80460587.eng.abstr-s1-t5",
"type": "umlsterm",
"text": [
"movement"
],
"offsets": [
[
168,
176
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0026649"
}
]
},
{
"id": "HNO.80460587.eng.abstr-s1-t6",
"type": "umlsterm",
"text": [
"reinnervation"
],
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[
212,
225
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0021516"
}
]
},
{
"id": "HNO.80460587.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"cell"
],
"offsets": [
[
285,
289
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0007634"
}
]
},
{
"id": "HNO.80460587.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"reinnervation"
],
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[
327,
340
]
],
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{
"db_name": "UMLS",
"db_id": "C0021516"
}
]
},
{
"id": "HNO.80460587.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"cell counting"
],
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[
285,
298
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0007584"
}
]
},
{
"id": "HNO.80460587.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"method"
],
"offsets": [
[
413,
419
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0025663"
},
{
"db_name": "UMLS",
"db_id": "C0025664"
}
]
},
{
"id": "HNO.80460587.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"reinnervation"
],
"offsets": [
[
468,
481
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0021516"
}
]
}
] |
[] |
[] |
[
{
"id": "HNO.80460587.eng.abstr-s1-r1-t5.1-t6.1",
"type": "result_of",
"arg1_id": "HNO.80460587.eng.abstr-s1-t5",
"arg2_id": "HNO.80460587.eng.abstr-s1-t6",
"normalized": []
},
{
"id": "HNO.80460587.eng.abstr-s1-r2-t1.1-t6.1",
"type": "affects",
"arg1_id": "HNO.80460587.eng.abstr-s3-t1",
"arg2_id": "HNO.80460587.eng.abstr-s1-t6",
"normalized": []
},
{
"id": "HNO.80460587.eng.abstr-s1-r3-t1.1-t5.1",
"type": "affects",
"arg1_id": "HNO.80460587.eng.abstr-s3-t1",
"arg2_id": "HNO.80460587.eng.abstr-s1-t5",
"normalized": []
},
{
"id": "HNO.80460587.eng.abstr-s1-r4-t3.1-t5.1",
"type": "location_of",
"arg1_id": "HNO.80460587.eng.abstr-s2-t3",
"arg2_id": "HNO.80460587.eng.abstr-s1-t5",
"normalized": []
},
{
"id": "HNO.80460587.eng.abstr-s1-r5-t6.1-t5.1",
"type": "result_of",
"arg1_id": "HNO.80460587.eng.abstr-s1-t6",
"arg2_id": "HNO.80460587.eng.abstr-s1-t5",
"normalized": []
},
{
"id": "HNO.80460587.eng.abstr-s1-r6-t1.1-t3.1",
"type": "part_of",
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"arg2_id": "HNO.80460587.eng.abstr-s2-t3",
"normalized": []
},
{
"id": "HNO.80460587.eng.abstr-s1-r7-t3.1-t6.1",
"type": "location_of",
"arg1_id": "HNO.80460587.eng.abstr-s2-t3",
"arg2_id": "HNO.80460587.eng.abstr-s1-t6",
"normalized": []
},
{
"id": "HNO.80460587.eng.abstr-s2-r1-t1.1-t2.1",
"type": "location_of",
"arg1_id": "HNO.80460587.eng.abstr-s3-t1",
"arg2_id": "HNO.80460587.eng.abstr-s3-t2",
"normalized": []
},
{
"id": "HNO.80460587.eng.abstr-s3-r1-t1.1-t2.1",
"type": "measurement_of",
"arg1_id": "HNO.80460587.eng.abstr-s3-t1",
"arg2_id": "HNO.80460587.eng.abstr-s3-t2",
"normalized": []
},
{
"id": "HNO.80460587.eng.abstr-s3-r2-t2.1-t1.1",
"type": "affects",
"arg1_id": "HNO.80460587.eng.abstr-s3-t2",
"arg2_id": "HNO.80460587.eng.abstr-s3-t1",
"normalized": []
}
] |
HNO.80460592.eng.abstr
|
HNO.80460592.eng.abstr
|
[
{
"id": "HNO.80460592.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Fifteen patients at the University of Mainz were diagnosed as having T3 or T4 carcinomas of the paranasal sinuses that invaded the orbit . Treatment involved surgical resections of tumor with adjacent periorbita but without enucleation in an attempt to preserve vision and/or cosmesis . Survival rates and especially the rate , time and locations of recurrences were investigated . Analysis of the data revealed that preservation of the eye in these cases with advanced sinus carcinomas with orbital tumor involvement did not seem to worsen prognosis . The individual gain in terms of quality of life through the preservation of vision and cosmesis seems to justify the surgical approach used ."
],
"offsets": [
[
0,
694
]
]
}
] |
[
{
"id": "HNO.80460592.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"patients"
],
"offsets": [
[
8,
16
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0030705"
}
]
},
{
"id": "HNO.80460592.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"University"
],
"offsets": [
[
24,
34
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0041740"
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[] |
[] |
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] |
HNO.80460598.eng.abstr
|
HNO.80460598.eng.abstr
|
[
{
"id": "HNO.80460598.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Since 1994 , the German Registry for Hearing Loss in Children has registered data of 1500 children and by now can present results concerning the age at diagnosis of permanent hearing loss in children in Germany . The mean age at diagnosis is still very high . There is a strong correlation between age at diagnosis and degree of hearing loss , i.e. , severe and profound hearing loss , is diagnosed distinctly earlier than mild and moderate hearing loss . On average , mild hearing loss is diagnosed with 6.2 years , moderate h.l. with 4.4 years , severe hearing loss with 2.5 years and profound hearing loss with 1.9 years . This corresponds with the results of regional German studies . At least regionally , in other European countries the age at diagnosis is known to be distinctly lower . In 36% of the children registered in Germany the delay between first suspicion and diagnosis of permanent hearing loss is 1 year or more ."
],
"offsets": [
[
0,
932
]
]
}
] |
[
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{
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] |
[] |
[] |
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HNO.80460606.eng.abstr
|
HNO.80460606.eng.abstr
|
[
{
"id": "HNO.80460606.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Oncocytomas of the minor salivary glands are uncommon epithelial tumors . Their occurrence is controversial because the formation of metastases and histological criteria of malignancy such as hypercellularity in connection with nuclear pleomorphism and local aggressive growth , have been described in only single cases . We report a case of a 66-year-old woman who was found to have an oncocytic adenoma localized in her left laryngeal vestibular ligament . Because no signs of malignancy could be found in our case the tumor was classified histologically as primary benign . We emphasize that thorough histological examination of oncocytic tumors and close clinical supervi-sion are necessary . A general overview of the available literature and the histological classification of oncocytomas is given ."
],
"offsets": [
[
0,
805
]
]
}
] |
[
{
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"Oncocytomas"
],
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[
0,
11
]
],
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},
{
"id": "HNO.80460606.eng.abstr-s1-t2",
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"minor"
],
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[
19,
24
]
],
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{
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"db_id": "C0026193"
}
]
},
{
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"tumors"
],
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65,
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]
],
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"db_id": "C0027651"
}
]
},
{
"id": "HNO.80460606.eng.abstr-s1-t4",
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"text": [
"salivary glands"
],
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[
25,
40
]
],
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{
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"db_id": "C0036098"
}
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},
{
"id": "HNO.80460606.eng.abstr-s1-t5",
"type": "umlsterm",
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"epithelial tumors"
],
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[
54,
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"db_id": "C0205853"
}
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},
{
"id": "HNO.80460606.eng.abstr-s1-t6",
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"minor salivary glands"
],
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[
19,
40
]
],
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{
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"db_id": "C0036099"
}
]
},
{
"id": "HNO.80460606.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"occurrence"
],
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[
80,
90
]
],
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}
]
},
{
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"text": [
"metastases"
],
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133,
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}
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},
{
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"text": [
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],
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161,
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}
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},
{
"id": "HNO.80460606.eng.abstr-s2-t4",
"type": "umlsterm",
"text": [
"malignancy"
],
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[
173,
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]
],
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}
]
},
{
"id": "HNO.80460606.eng.abstr-s2-t5",
"type": "umlsterm",
"text": [
"hypercellularity"
],
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[
192,
208
]
],
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{
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"text": [
"growth"
],
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270,
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}
]
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{
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"single"
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},
{
"id": "HNO.80460606.eng.abstr-s3-t1",
"type": "umlsterm",
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"woman"
],
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},
{
"id": "HNO.80460606.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"adenoma"
],
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397,
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},
{
"id": "HNO.80460606.eng.abstr-s3-t3",
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"ligament"
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{
"id": "HNO.80460606.eng.abstr-s3-t4",
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{
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{
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{
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{
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},
{
"id": "HNO.80460606.eng.abstr-s6-t3",
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],
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[
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],
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{
"db_name": "UMLS",
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}
]
}
] |
[] |
[] |
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},
{
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},
{
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},
{
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},
{
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},
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},
{
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},
{
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},
{
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{
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{
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}
] |
HNO.80460643.eng.abstr
|
HNO.80460643.eng.abstr
|
[
{
"id": "HNO.80460643.eng.abstr-passage-0",
"type": "abstract",
"text": [
"It is the task of each medical specialty to develop guidelines for diagnosis and therapies . Examinations done by several specialties should follow a common consensus . A randomized survey at 70 German ENT departments investigated the current position of tracheobronchoscopy and esophagoscopy at each institution . Sixty questionnaires were evaluable . Altogether 8,295 tracheobronchoscopies and 10,404 esophagoscopies were performed . Thirty-six percent of all tracheobronchoscopies and 6% of all esophagoscopies were done with a flexible system . Approximately 58% of all tracheobronchoscopies and 55% of all esophagoscopies were performed for tumor staging . Complications during tracheobronchoscopy occurred in 0.8% of cases and in 0.58% of the esophagoscopies . Using these data an interdisciplinary quality assurance concept was developed for tracheobronchoscopy and esophagoscopy . Current experience has shown that a otolaryngologists in Germany mainly perform rigid tracheobronchoscopy and esophagoscopy . Although endoscopy is mostly done in cases with varied anatomic structures , complications are very rare and comparable to flexible techniques . Greater experience with flexible systems also is to be encouraged in ENT departments ."
],
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}
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[] |
[] |
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HNO.80460660.eng.abstr
|
HNO.80460660.eng.abstr
|
[
{
"id": "HNO.80460660.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Percutaneous endoscopically controlled gastrostomy ( PEG ) enables patients suffering from a tumor of the upper aerodigestive tract to receive direct gastric feedings . The procedure also avoids the social stigma of a nasal feeding tube . The results of 630 PEG procedures used in 555 patients suffering from various head and neck cancers are reported . The mean age of the patients was 58.0 years with a range from 11 to 92 years . The PEG procedure was carried out under local anesthesia in 60% of the cases and with general anesthesia in 40% . In 512 patients the initial PEG procedure was successful while 43 of the patients required a second PEG procedure after loss of the PEG . In 19 patients the PEG procedure was not successful because of tumor obstruction or it was not possible to perform endoscopy . Twenty-four patients were successfully treated in a second or third session . Altogether 97% ( n = 563 ) of all 555 patients and 92% ( n = 579 ) of all PEG procedures were successful . The mean duration of PEG use was 243 days ( range : 0-2271 days ) . In 66 patients ( 10.5% ) complications occurred but severe complications developed in only 8 patients ( 1.3% ) . Operative interventions were necessary in two cases . No deaths resulted from the PEG . These findings show that the PEG technique is safe to do with only few complications when performed by a skilled team ."
],
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] |
[] |
[] |
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] |
HNO.80460666.eng.abstr
|
HNO.80460666.eng.abstr
|
[
{
"id": "HNO.80460666.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Retrograde or fiberoptic intubation techniques are recommended for patients in whom intubation is difficult ; however , each method has its own limitations . Good results have been reported with a combination of both techniques , i.e. retrograde passage of a guidewire through the cricothyroid membrane to guide a fiberoptic bronchoscope . The practicality , success and complication rates of our retrograde-guided fiberoptic bronchoscopic technique ( RGFT ) were studied prospectively in 93 patients with obstructing tumors scheduled for laryngectomy . The technique showed itself to be successful , practical and safe , with negligible complications in 89/93 patients ( 96% ) . The ability to insert the bronchoscope by means of a guidewire and to direct the intubation procedure optically was found to be advantageous . Limitations were found in two patients with extreme obesity and in two other patients with advanced obstructive carcinomas of the larynx . Additionally , use of the tracheal puncture allows the RGFT to be integrated into clinical medical education as a preparatory exercise for emergency coniotomy ."
],
"offsets": [
[
0,
1122
]
]
}
] |
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[] |
[] |
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] |
HNO.80460672.eng.abstr
|
HNO.80460672.eng.abstr
|
[
{
"id": "HNO.80460672.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Cold knife surgery , electrosurgery and laser surgery all offer techniques , instruments , equipment and systems for resecting and destroying mucosal lesions and for hemostasis in the upper aerodigestive tract . When used in the head and neck , argon plasma surgery ( APS ) offers a new , contact-free , electrosurgical technique in which high-frequency current is applied through ionized , and thus electrically conductive , argon ( argon plasma ) to the tissue undergoing treatment . Especially noteworthy in APS are its advantages for removing a lesion and controlling bleeding : the technique is easy to control , and the depth of thermal tissue destruction is limited to a maximum of 3 mm even in wide-area application , so that damage to adjacent or submucosal tissues can be avoided . Initial results with APS in the reduction of hyperplastic nasal turbinates , treatment of hereditary hemorrhagic teleangiectasia ( Osler's disease ) in the nasal mucosa , and in treating progressive juvenile papillomatosis of the larynx have shown clear advantages for APS over other methods used ."
],
"offsets": [
[
0,
1090
]
]
}
] |
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] |
[] |
[] |
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HNO.80460684.eng.abstr
|
HNO.80460684.eng.abstr
|
[
{
"id": "HNO.80460684.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The need for an objective assessment of voice quality can be seen in the increasing use of acoustic analysis methods for clinical diagnosis and research . The hoarseness diagram allows clinicians to objectively describe even highly disturbed or aphonic voices . Its application possibilities are illustrated in three case studies in which changes in voice quality were monitored during voice rehabilitation . The distributions of voice groups that were defined on the basis of specific pathophysiological phonation conditions were then compared for their acoustic differences . The groups comprised various phonation conditions after the resections of laryngeal tumors and different types of laryngeal paralyses . Interpretation of the results suggests a direct correspondence of the hoarseness diagram coordinates and the irregularity of vibration on the one side and the degree of glottal closure on the other . This illustrates the potential usefulness of the hoarseness diagram in a clinical context ."
],
"offsets": [
[
0,
1005
]
]
}
] |
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HNO.80460692.eng.abstr
|
HNO.80460692.eng.abstr
|
[
{
"id": "HNO.80460692.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The Tullio phenomenon is defined as an acoustically inducible vestibular disorder that was first described in 1929. In an animal experiment Tullio provoked acoustic oscillations at the labyrinth followed by signs of imbalance . In the literature this phenomenon can be found in healthy but sensitive persons as well as in patients with Meniere's disease and patients with lesions between the stapes , footplate and the membranous labyrinth caused by fractures , stapes dislocations , labyrinthitis or perilymphatic fistulas . In this case report a patient complained about vertigo after cochlear implantation provoked by acoustical stimulation at a sound pressure level above 90 dB independent of the cochlear implant ( CI ) . During tympanoscopy we found scar tissue surrounding the ossicles after CI . After disconnecting the ossicular chain no vertigo or nystagmus could be provoked . After CI regular ENT examinations and appropriate explorations of postoperative complaints are necessary . Vertigo especially requires very careful diagnostic procedures ."
],
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[
0,
1059
]
]
}
] |
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] |
[] |
[] |
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HNO.80460712.eng.abstr
|
HNO.80460712.eng.abstr
|
[
{
"id": "HNO.80460712.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Dysphagia is related to the impairment of food passage from the mouth to the stomach . Globus pharyngis implies the frequent and often painful sensation of a lump in the throat that usually does not interfere with swallowing and may even be relieved by food intake . The diagnosis is based upon a careful history , clinical examination , endoscopy , dynamic imaging ( videofluoroscopy , cinematography , videosonography ) and electrophysiologic procedures ( including pharyngoesophageal manometry , electromyography and pH determinations ) . Structural lesions of the cervical spine such as diffuse idiopathic skeletal hyperostosis are rare causes of dysphagia . Dysphagia following anterior cervical fusion as well as globus and dysphonia due to dysfunction of the vertebral joints are more likely . Symptoms with swallowing fluids indicate a neurogenic origin . Dyscoordinated swallowing , nasal reflux , dysphonia or general weakness may also occur . Chronic aspiration with respiratory compromize is the main consequence in a variety of neurological disorders as well as in cases of postsurgical dysphagia . Relaxation of the upper esophageal sphincter indicates coordinated muscle movement between the pharynx and esophagus . Dysfunction of the pharyngoesophageal segment may lead to cricopharyngeal achalasia . A dyskinetic sphincter commonly represents an extrapharyngeal cause : i.e. , disease associated with gastroesophageal reflux . Disorders of the esophageal phase of deglutition can produce retrosternal pain , heartburn , regurgitation and vomiting , as well as laryngeal and respiratory signs . Esophageal motility disorders include lower achalasia , tumors , peptic strictures , inflammatory diseases , drug-induced ulcers , rings and webs . Motility disorders present with aperistaltic , spontaneous contractions , diffuse esophagospasm , or a hypermotile esophagus . Gastroesophageal reflux with esophagitis must always be excluded , especially in patients with a globus sensation . The multiple features of the appearance of the symptoms of dysphagia and globus makes multidisciplinary approach necessary in order to establish a diagnosis and begin effective treatment ."
],
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0,
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] |
[] |
[] |
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}
] |
HNO.80460731.eng.abstr
|
HNO.80460731.eng.abstr
|
[
{
"id": "HNO.80460731.eng.abstr-passage-0",
"type": "abstract",
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"In addition to mucositis and myelotoxicity as well known early reactions after radiotherapy or radiochemotherapy in advanced head and neck tumors , late toxicity following treatment is an often underestimated problem ."
],
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[
0,
218
]
]
}
] |
[
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],
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79,
91
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}
]
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139,
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"id": "HNO.80460731.eng.abstr-s1-t5",
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],
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153,
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172,
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]
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}
]
},
{
"id": "HNO.80460731.eng.abstr-s1-t7",
"type": "umlsterm",
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"neck tumors"
],
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134,
145
]
],
"normalized": [
{
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}
]
}
] |
[] |
[] |
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}
] |
HNO.80460739.eng.abstr
|
HNO.80460739.eng.abstr
|
[
{
"id": "HNO.80460739.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The current adjustment of cochlear implant ( CI ) speech processors is based on a knowledge of the lower and upper limits ( T- and C-levels ) for electrical stimulus currents . These data are usually acquired from subjective classifications of individual patients . In cases with non-reliable patient responses , objective methods are necessary . Especially for the estimation of correct T-levels , auditory evoked potentials ( AEP ) can be applied , since they allow the determination of response thresholds in a frequency-specific manner . By determining the AEP of different latencies , late cortical responses can be registered almost without artifact contamination . These patients have been examined in 20 patients provided with 22- or 8-channel CI-systems ( Nucleus or Med-El implants ) . In all cases , clear responses and clearly discernible threshold transitions could be detected . By making use of acoustical stimulation in a free sound field , subjective hearing threshold and the T-levels of electrical stimulation could be verified . Since late responses are generated in the primary auditory cortex , their assessment permits a nearly integral functional control of the aided hearing system . To date , no problems have occured from maturation or attentional effects in either pediatric or adult patients . The applicability in very young children remains to be explored ."
],
"offsets": [
[
0,
1388
]
]
}
] |
[
{
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12,
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]
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}
]
},
{
"id": "HNO.80460739.eng.abstr-s1-t2",
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"speech"
],
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[
50,
56
]
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{
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26,
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}
]
},
{
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225,
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{
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}
] |
[] |
[] |
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}
] |
HNO.80460748.eng.abstr
|
HNO.80460748.eng.abstr
|
[
{
"id": "HNO.80460748.eng.abstr-passage-0",
"type": "abstract",
"text": [
"In the present study we investigated resected tympanic membranes taken during tympanoplasty . Tissue from 111 patients with chronic otitis media was analyzed after being embedded in paraffin and stained with hematoxylin and eosin . In 67 patients ( 60% ) the tympanic membrane epidermis did not extend beyond the margin of the perforation rim , so that no epithelial migration was observed on the inner side of the tympanic membrane . In 27 specimens ( 24% ) we found an epithelial migration on the inner side of the tympanic membrane , but this did not extend to the margins of the excised tissue . In 17 tissue specimens ( 16% ) epithelial migration extended to the margins of the resected tissue . Clinically , these patients were found to have non-functioning Eustachian tubes . The size of the tympanic membrane perforation was not found to impact on epithelial migration . However , there was a correlation between the extent of the epithelial migration seen in the specimens and the occurrence of a permanent tympanic membrane perforation after tympanoplasty . Of 17 patients with these findings , 4 ( 23% ) had consistent reperforations . The tympanic membrane rims of these patients were completely covered with squamous epithelium . Patients with no or only little epithelial migration to the inner side of the tympanic membrane were found to have a significantly lower postoperative rate of recurrent infection and drum reperforation ."
],
"offsets": [
[
0,
1446
]
]
}
] |
[
{
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"membranes"
],
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[
55,
64
]
],
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{
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"db_id": "C0025255"
}
]
},
{
"id": "HNO.80460748.eng.abstr-s1-t2",
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"text": [
"tympanoplasty"
],
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[
78,
91
]
],
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"db_id": "C0041447"
}
]
},
{
"id": "HNO.80460748.eng.abstr-s1-t3",
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"tympanic membranes"
],
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[
46,
64
]
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]
},
{
"id": "HNO.80460748.eng.abstr-s2-t1",
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"Tissue"
],
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[
94,
100
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{
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{
"id": "HNO.80460748.eng.abstr-s2-t3",
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"otitis"
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132,
138
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{
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"media"
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}
]
},
{
"id": "HNO.80460748.eng.abstr-s2-t5",
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"paraffin"
],
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[
182,
190
]
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"db_id": "C0030415"
}
]
},
{
"id": "HNO.80460748.eng.abstr-s2-t6",
"type": "umlsterm",
"text": [
"hematoxylin"
],
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[
208,
219
]
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{
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"db_id": "C0018964"
}
]
},
{
"id": "HNO.80460748.eng.abstr-s2-t7",
"type": "umlsterm",
"text": [
"eosin"
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[
224,
229
]
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"db_id": "C0014448"
}
]
},
{
"id": "HNO.80460748.eng.abstr-s2-t8",
"type": "umlsterm",
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"otitis media"
],
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132,
144
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},
{
"id": "HNO.80460748.eng.abstr-s3-t1",
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238,
246
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]
},
{
"id": "HNO.80460748.eng.abstr-s3-t2",
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"membrane"
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268,
276
]
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}
]
},
{
"id": "HNO.80460748.eng.abstr-s3-t3",
"type": "umlsterm",
"text": [
"epidermis"
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] |
[] |
[] |
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HNO.80460757.eng.abstr
|
HNO.80460757.eng.abstr
|
[
{
"id": "HNO.80460757.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Conductive and sensorineural hearing losses are of genetic origin in 20% to 60% of cases . In general , genetic abnormalities are more often expressed as a sensorineural hearing loss than as a conductive hearing loss . At present several genes for sensorineural hearing loss have been isolated . The most common genetically transmitted forms for isolated conductive hearing losses are otosclerosis and small malformations of the ossicles . To date no genes responsible for these deformations have been isolated . We present a family with four siblings having conductive hearing losses caused by ossification of the stapedial tendon . This finding is suggestive of an autosomal recessive inheritance . The early diagnosis of an hereditary conductive hearing loss contains the possibility for permitting normal development of speech ."
],
"offsets": [
[
0,
832
]
]
}
] |
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[] |
[] |
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HNO.80460762.eng.abstr
|
HNO.80460762.eng.abstr
|
[
{
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"type": "abstract",
"text": [
"Aneurysms of the temporal part of the carotid artery are unusually rare . The literature contains only a few previous reports dealing with hemorrhage from such malformations . In the present case massive bleeding occurred from a right-sided intrapetrous aneurym after myringotomy , which was performed as treatment for bilateral secretory otitis media . Due to the absence of any specific symptoms and the masking effect of middle ear glue preoperative identification of the aneurysm was not possible . Subsequent angiography showed the large fusiform extension of the intrapetrous aneurysm as well as multiple intracranial aneurysms . Leakage from the aneurism was closed definitively with muscle , fascia lata and a gelatin-resorcin-formalin-glue ( Cardial ) . In order to apply the tissue patch the hypotympanic site of the aneurism was exposed using a posterior otosurgical approach . Due to extensive intracranial collateralization to the vertebral arteries bleeding persisted even after ligation of both carotid arteries . Temporary cardiac asystole was then induced to allow safe closure of the aneurysm . Following surgery the patient sustained loss of hearing in her ear and a partial peripheral facial palsy ."
],
"offsets": [
[
0,
1219
]
]
}
] |
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}
] |
[] |
[] |
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HNO.80460799.eng.abstr
|
HNO.80460799.eng.abstr
|
[
{
"id": "HNO.80460799.eng.abstr-passage-0",
"type": "abstract",
"text": [
"We have reviewed 103 cases of rigid tracheobronchoscopies that were performed in pediatric patients at the ENT University Hospital in Tuebingen between 1989 and 1997. In 84% of our patients the indication for en- doscopy was the suspicion of foreign body aspiration , while others were congenital dysplasia in the tracheobronchial tree , tracheomalacia or lesions after long-term intubation . After evaluation of all rigid bronchoscopies in children through age 12 , we found that 69% had one or more foreign bodies . Except for one case of a needle , all foreign bodies could be removed by rigid bronchoscopy . There were no serious complications such as bleeding or airway obstruction requiring tracheotomy . At the University Hospital rigid tracheobronchoscopy was found to be an effective and safe procedure . In particular , the procedure should be carried out if the history or clinical findings suggest foreign body aspiration ."
],
"offsets": [
[
0,
935
]
]
}
] |
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] |
[] |
[] |
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] |
HNO.80460804.eng.abstr
|
HNO.80460804.eng.abstr
|
[
{
"id": "HNO.80460804.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The growth of a cholesteatoma requires angioneogenesis in the connective tissue of the perimatrix . Angioneogenesis is also needed for wound healing as a host response to tissue injury . Normal wound repair is conducted through a wide number of growth factors . Basic fibroblast growth factor ( b-FGF ) plays a pivotal role in wound repair . This cytokine exerts its effects through stimulation of a wide range of target cells . B-FGF is chemotactic and mitogenic for fibroblasts , endothelial cells and keratinocytes . In addition , b-FGF can stimulate the production of collagenase and plasminogen activators to enhance fibroblast proliferation and angioneogenesis . Its necessity for normal wound repair has been confirmed by several workers ."
],
"offsets": [
[
0,
746
]
]
}
] |
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] |
[] |
[] |
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] |
HNO.80460809.eng.abstr
|
HNO.80460809.eng.abstr
|
[
{
"id": "HNO.80460809.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The authors describe a study in progress to identify Turkish families with hereditary hearing loss and isolate possible responsible disease genes . Due to extreme genetic heterogeneity and limited audiological differentiation of hereditary hearing loss , it is necessary to identify large or small families from genetic isolates to locate loci responsible for hearing loss on a chromosome . To accomplish this goal , the medical records of 3800 children were examined at the ENT Clinic of Ege University between 1975 and 1994. All were suspected of having various hearing impairments . Additionally , students from two schools for the hearing impaired in Izmir and Eskisehir , Turkey were examined . To date , 16 families with syndromal deafness and 55 families with non-syndromal hereditary hearing loss involving two or more affected individuals have been identified and categorized according to the mode of inheritance . The majority ( 66% ) of the non-syndromal families showed an autosomal recessive pattern , 29% an autosomal dominant inheritance and 5% an X-linked mode of inheritance . In the study presented there has been a predominance of affected males versus females and the consanguinity rate was 22% ."
],
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0,
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]
}
] |
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]
}
] |
[] |
[] |
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}
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HNO.80460815.eng.abstr
|
HNO.80460815.eng.abstr
|
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{
"id": "HNO.80460815.eng.abstr-passage-0",
"type": "abstract",
"text": [
"In order to understand the repeated occurrences of auditory impairments caused by toy pistols , an analysis of the circumstances involved was performed at Justus-Liebig University of Giessen . The accoustic impact of toy pistols on the ear was determined with a special measuring system for impulse noise . Results were compared with the acoustic impacts of the G3 common rifle of the German military on the ear of the soldier . It was apparent that all of the five randomly selected types of toy pistols were much louder than the military rifle , if fired close to the ear . The current standard of the European Union related to the safety of toys ( EN 71-1 ) tolerates peaks of impulse noise from toy pistols that are actually illegal for workplaces without auditory protection . Measurements showed that the toy pistols tested were even louder than that tolerated by the EU standard . Problems related to acute acoustic trauma caused by these toys are discussed using recent examples . In order to prevent such injuries , we suggest limiting the loudness of the \" worst case \" instead of using unrealistic measurements ."
],
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[
0,
1123
]
]
}
] |
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}
] |
[] |
[] |
[
{
"id": "HNO.80460815.eng.abstr-s1-r1-t1.1-t3.1",
"type": "carries_out",
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},
{
"id": "HNO.80460815.eng.abstr-s1-r2-t3.1-t1.1",
"type": "measures",
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{
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{
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},
{
"id": "HNO.80460815.eng.abstr-s5-r3-t7.1-t1.1",
"type": "produces",
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},
{
"id": "HNO.80460815.eng.abstr-s6-r1-t3.2-t1.1",
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{
"id": "HNO.80460815.eng.abstr-s7-r1-t1.1-t3.1",
"type": "result_of",
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"type": "associated_with",
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},
{
"id": "HNO.80460815.eng.abstr-s7-r3-t3.1-t2.1",
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{
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{
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{
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"normalized": []
}
] |
HNO.80460821.eng.abstr
|
HNO.80460821.eng.abstr
|
[
{
"id": "HNO.80460821.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Basal cell adenocarcinoma is a rare entity that was first defined as a malignant salivary gland tumor in 1991. We present another case report and discuss pathology , pathogenesis , differential diagnosis , therapy and prognosis on the basis of currently available literature . Although histomorphologic features of the tumors are similar to basal cell adenomas , proof of an infiltrative and destructive growth is essential for diagnosis . Adenoid cystic carcinoma and basaloid squamous carcinoma must also be considered in any differential diagnosis . Tumor development within a pre-existing basal cell adenoma and de novo development are discussed ."
],
"offsets": [
[
0,
651
]
]
}
] |
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{
"id": "HNO.80460821.eng.abstr-s1-t2",
"type": "umlsterm",
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"adenocarcinoma"
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11,
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{
"id": "HNO.80460821.eng.abstr-s1-t3",
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"tumor"
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{
"id": "HNO.80460821.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"tumors"
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] |
[] |
[] |
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HNO.80460844.eng.abstr
|
HNO.80460844.eng.abstr
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"For the majority of patients with sensorineural hearing loss ( SNHL ) many available hearing aids often do not achieve satisfactory results . For these patients partially implantable hearing devices have been developed , allowing distortion-free hearing and speech intelligibility that may be superior to conventional hearing aids . The external parts of partial implants , however , may result in a patient's stigmatization . Furthermore , they do not use the acoustic properties of the external auditory canal . Recently , we published the successful development of the first totally implantable hearing device for the treatment of SNHL ( HNO 46 [ 1998 ] 853-863 ) . Here we report the first implantations of this unique , totally implantable electronic hearing system in patients with SNHL : Implex TICA LZ 3001. The implant microphone is implanted subcutaneously in the outer ear canal near the ear drum . The signal is processed by a digitally programmable multichannel audioprocessor located subcutaneously on the bony skull behind the ear . A piezoelectric transducer is coupled to the body of the incus and drives the ossicular chain by vibratory actions . Energy is provided by an implantable battery . Implanted patients describe hearing as being distortion-free and transparent . Speech intelligibility and the hearing of music are improved . Patients may achieve better speech discrimination , especially in the presence of background noise . The aid can be used during sports , including swimming . To our knowledge , this is the first report of the implantation of a totally implantable electronic hearing system in patients . These results encourage further implantations of the totally implantable hearing system in the course of an ongoing clinical study ."
],
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[] |
[] |
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HNO.80460853.eng.abstr
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HNO.80460853.eng.abstr
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"Recently , Zenner et al. implanted the first totally implantable electronic hearing devices in patients with SNHL ( HNO 46 [ 1998 ] 844-852 ) . In the present report , technical and audiological features of the implant TICA are published . The development of the piezoelectric transducer and the microphone for implantation in the posterior wall of the auditory canal as components for the present fully implantable hearing system has already been described ( HNO 45 , 1997 , 792-880 ) . Here we report about our experience with the electronic main module that completes the TICA LZ 3001 system . This module is suited for implantation in the mastoid bone and contains the signal-processing electronics and an integrated battery that can be recharged transcutaneously with a portable charger . The recharging time is around 2 h for an implant operating time of 50h . The microphone and transducer connectors allow for easy replacement of the main module when the battery lifetime is reached . This lifetime is around 3-5 years . A small wireless remote control allows volume adjustment , contains an on/off switch , and permits selection of four different individual hearing programs . The basic audiological features are provided by a flexible , digitally programmable 3-channel-AGC-system with a peak clipping function . The total bandwidth is around 10 kHz . To our knowledge this is the first fully implantable hearing system that has been in implanted in humans ."
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[] |
[] |
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HNO.80460870.eng.abstr
|
HNO.80460870.eng.abstr
|
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"The CO2 laser myringotomy is a current low-pain procedure for middle-ear ventilation for secretory otitis media ( SOM ) that can be performed under topical anesthesia , even in children . The duration of middle-ear ventilation is essentially determined by the size of the perforation created . Perforations with a diameter greater than 2 mm ventilate the tympanic cavity for approximately 3 weeks , thus avoiding tympanic ventilation tubes . To date , the CO2 laser beam can only be reliably applied to the tympanic membrane via a micromanipulator system coupled to an ear microscope . The CO2 laser otoscope is a new application system that markedly reduces the technical complexity of surgery and improves the mobility and availability of the system . The incorporation of a small inexpen-sive CO2 laser in the otoscope represents a significant development in SOM therapy ."
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] |
[] |
[] |
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}
] |
HNO.80460879.eng.abstr
|
HNO.80460879.eng.abstr
|
[
{
"id": "HNO.80460879.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The case of a 22-year-old nurse with Muenchhausen syndrome is described . Faked symptoms included sudden hearing loss and fever . In addition to the definition and classification , clues for diagnosis of faked disease are given . Early diagnosis avoids unnecessary diagnostic and therapeutic procedures . The prognosis of Muenchhausen's syndrome depends on the ability to establish an effective doctor-patient relationship , even though the nature of disease renders any treatment difficult ."
],
"offsets": [
[
0,
492
]
]
}
] |
[
{
"id": "HNO.80460879.eng.abstr-s1-t1",
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"nurse"
],
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[
26,
31
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0028677"
},
{
"db_name": "UMLS",
"db_id": "C0028661"
}
]
},
{
"id": "HNO.80460879.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"syndrome"
],
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[
50,
58
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0039082"
}
]
},
{
"id": "HNO.80460879.eng.abstr-s2-t1",
"type": "umlsterm",
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"symptoms"
],
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[
80,
88
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0683368"
}
]
},
{
"id": "HNO.80460879.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"hearing"
],
"offsets": [
[
105,
112
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0018767"
}
]
},
{
"id": "HNO.80460879.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"fever"
],
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[
122,
127
]
],
"normalized": [
{
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"db_id": "C0015967"
}
]
},
{
"id": "HNO.80460879.eng.abstr-s2-t4",
"type": "umlsterm",
"text": [
"hearing loss"
],
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[
105,
117
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0011053"
}
]
},
{
"id": "HNO.80460879.eng.abstr-s2-t5",
"type": "umlsterm",
"text": [
"sudden hearing loss"
],
"offsets": [
[
98,
117
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0011057"
}
]
},
{
"id": "HNO.80460879.eng.abstr-s3-t1",
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"text": [
"classification"
],
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[
164,
178
]
],
"normalized": [
{
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"db_id": "C0008902"
},
{
"db_name": "UMLS",
"db_id": "C0008903"
}
]
},
{
"id": "HNO.80460879.eng.abstr-s3-t2",
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"text": [
"diagnosis"
],
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[
191,
200
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0011900"
},
{
"db_name": "UMLS",
"db_id": "C0348026"
}
]
},
{
"id": "HNO.80460879.eng.abstr-s3-t3",
"type": "umlsterm",
"text": [
"disease"
],
"offsets": [
[
210,
217
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0012634"
}
]
},
{
"id": "HNO.80460879.eng.abstr-s4-t1",
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[] |
[] |
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] |
HNO.80460903.eng.abstr
|
HNO.80460903.eng.abstr
|
[
{
"id": "HNO.80460903.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Fetal surgery is defined as the intrauterine surgical correction of malformations that endanger the unborn child's life in prenatal stages of development or lead to death or severe damage of the child postnatally . Such surgery is a clinical reality now . Indications for intrataurine surgical procedures also exist for head and neck abnormalities , especially in the upper respiratory tract . These include exposure and temporary obstruction of the fetal trachea for correction of pulmonary hypoplasia in cases with congenital diaphragmatic hernias , prenatal tracheotomy in cases of laryngeal atresia for the correction of lethal pulmonary overdistension , and resection of embryonic tumors that obstruct the respiratory tract . The relatively high surgical risk resulting in particular from preterm labor occurring postoperatively may be reduced by employing minimally invasive techniques . Endoscopic procedures render opening of the uterus unnecessary and are of particular importance . In part of the procedures , only endoscopic surgery has led to therapeutic success rates justifying its clinical use . Further reduction of the operative risk suggests prenatal interventions , even in cases with non-lethal conditions . More diseases of the head and neck may thus be included in the spectrum of indications . One example is prenatal correction of a cleft lip and palate , which until now has only been performed in animal experiments . The particular characteristics of fetal wound healing allow this to take place without scarring up to a certain stage in pregnancy . This offers the prospect of a surgical correction that is invisible externally and avoids growth-impeding scars . The particular ethical and legal aspects of fetal surgery are discussed ."
],
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[
0,
1764
]
]
}
] |
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{
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{
"id": "HNO.80460903.eng.abstr-s4-t2",
"type": "umlsterm",
"text": [
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] |
[] |
[] |
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] |
HNO.80460914.eng.abstr
|
HNO.80460914.eng.abstr
|
[
{
"id": "HNO.80460914.eng.abstr-passage-0",
"type": "abstract",
"text": [
"There are different hypotheses for the development of epitympanic retraction pockets . These can occur as the result of an inflammatory process and negative pressure in the middle ear spaces . Anatomic bottlenecks in the middle ear favor diminished inflation of the epitympanic space . The eustachian tube provides pressure equilibration in the middle ear . Its dysfunction involving tubal opening or closing is thought to be the main reason for a permanent negative pressure in the middle ear . A patulous eustachian tube is now claimed for prolonged negative pressure in the middle ear and is caused by a so-called \" sniffing \" habit . The purpose of this study was to elucidate objectively the frequency of patulous eustachian tubes in ears with epitympanic retraction pockets . We examined passive tubal function in 41 patients with 50 epitympanic retraction pockets by using dual impedance in a pressure chamber . We identified three stages of epitympanic retraction pockets . Stage 1 involved a mobile and controllable retraction pocket ; stage 2 corresponded with a fixed but controllable pocket , whereas stage 3 described a fixed pocket that was developing into a cholesteatoma . Results were compared with the function tests of 100 healthy ears in 50 normal individuals . We found 27 patulous eustachian tubes in patients with epitympanic retraction pockets , 22 of which occurred in affected ears while only 2 patulous tubes were found in the group of the healthy ears . Tubal opening pressure ( P 0.001 ) and tubal closing pressure ( P 0.01 ) were significantly lower in ears with epitympanic retraction pockets than in healthy ears ."
],
"offsets": [
[
0,
1646
]
]
}
] |
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}
] |
[] |
[] |
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] |
HNO.80460919.eng.abstr
|
HNO.80460919.eng.abstr
|
[
{
"id": "HNO.80460919.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Between 1983 and 1991 ten patients with chronic frontal sinus disease underwent frontal osteoplastic flaps with fat obliteration . In order to judge operative success on a long-term basis all patients were called for postoperative follow-up . They then completed a questionaire , in which they were asked about postoperative complaints . Additionally , sinuses were examined by computed tomographic ( CT ) and magnetic resonance imaging ( MR ) . Among the patients evaluated seven had no complaints , and no evidence of disease could be found by medical examination . CT scans showed complete obliteration of the frontal sinuses in all patients . In these patients , two-thirds of the fat had been replaced by connective tissue . MR was used in an attempt to show evidence for suppurative disease in the frontal sinus , but the MR images failed to correlate with symptoms . Additional results could not be obtained when compared to CT . Overall operating success could only be determined by clinical assessment and confirmed the value of the frontal osteoplastic flap with fat obliteration ."
],
"offsets": [
[
0,
1091
]
]
}
] |
[
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"patients"
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34
]
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{
"id": "HNO.80460919.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"sinus"
],
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[
56,
61
]
],
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{
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"db_id": "C0030471"
}
]
},
{
"id": "HNO.80460919.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"disease"
],
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[
62,
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{
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}
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{
"id": "HNO.80460919.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"flaps"
],
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[
101,
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]
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},
{
"id": "HNO.80460919.eng.abstr-s1-t5",
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"text": [
"fat"
],
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[
112,
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{
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"frontal sinus"
],
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48,
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{
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"postoperative"
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{
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]
},
{
"id": "HNO.80460919.eng.abstr-s4-t1",
"type": "umlsterm",
"text": [
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] |
[] |
[] |
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"id": "HNO.80460919.eng.abstr-s10-r3-t3.1-t1.1",
"type": "evaluation_of",
"arg1_id": "HNO.80460919.eng.abstr-s10-t3",
"arg2_id": "HNO.80460919.eng.abstr-s10-t1",
"normalized": []
},
{
"id": "HNO.80460919.eng.abstr-s10-r4-t3.1-t1.1",
"type": "location_of",
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"arg2_id": "HNO.80460919.eng.abstr-s10-t1",
"normalized": []
}
] |
HNO.80460925.eng.abstr
|
HNO.80460925.eng.abstr
|
[
{
"id": "HNO.80460925.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Oral food intake in patients with obstructing pharyngeal and esophageal carcinomas is commonly insufficient because of tumor-induced dysphagia which gives rise to cachexia unless treated . While entailing an unfavorable prognosis , malnutrition is often a therapy-limiting factor . Tube feeding with liquid formula diets currently offers the most efficient and least-risky approach to long-term use and is best adopted even at a pre-treatment stage irrespective of the tumor therapy intended . A feeding tube placed by a percutaneous endoscopically controlled gastrostomy ( PEG ) increasingly offers an alternative to a nasogastric tube . After using diaphanoscopy , the stomach is punctured from outside under local anesthesia and a feeding tube inserted by means of a retrograde thread or a direct puncture method . A modification of the direct puncture method has been preferred at the Magdeburg University E.N.T. Department . The tube is held in place by thermally activated helical winding of a gastic tube end ( using a memory-retaining helix ) . During the 1991-1996 period 415 patients with obstructing carcinomas of the upper digestive tract were treated with a feeding tube . No fatal complications were observed . Severe complications ( peritonitis ) occurred in three patients . In 160 patients with PEG the following parameters were recorded : weight-to-size index , body mass index , degree of dysphagia , nutrition status , lymphocyte count , total serum protein and patients ' compliance to PEG . The enteral nutrition therapy used was indicated in all of the patients treated with advanced carcinomas of the head and neck . In 81% of the patients the compliance to PEG was positive . Findings demonstrated that long-term intestinal nutrition via PEG was a safe and effective form of treatment . Inserting the tube by the direct puncture method was advantageous for patients with carcinomas in the upper digestive tract as only few mechanical alterations take place along tumorous tissues following PEG while contamination with bacteria and neoplastic cells from the tumor region into the abdomen are precluded ."
],
"offsets": [
[
0,
2128
]
]
}
] |
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{
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]
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"patients"
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]
},
{
"id": "HNO.80460925.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"esophageal"
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}
]
},
{
"id": "HNO.80460925.eng.abstr-s1-t4",
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"carcinomas"
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{
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}
]
},
{
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}
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"type": "umlsterm",
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},
{
"id": "HNO.80460925.eng.abstr-s3-t6",
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},
{
"id": "HNO.80460925.eng.abstr-s3-t7",
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]
},
{
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"type": "umlsterm",
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{
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{
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{
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{
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{
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{
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{
"id": "HNO.80460925.eng.abstr-s7-t1",
"type": "umlsterm",
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"gastic"
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]
},
{
"id": "HNO.80460925.eng.abstr-s7-t2",
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"gastic"
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}
]
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{
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"helix"
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{
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]
},
{
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]
},
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},
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]
},
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] |
[] |
[] |
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] |
HNO.80460932.eng.abstr
|
HNO.80460932.eng.abstr
|
[
{
"id": "HNO.80460932.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Following the recommendations of the United States National Institutes of Health Consensus Conference in 1993 , otoacoustic emissions ( OAE ) are now used internationally for hearing screening . The use of recording systems as well as the interpretation of results requires specially trained personnel although measurements are easier to perform than other recording methods available . To date , no objective method for general hearing screening , has been introduced in Germany , for neonates or children at risk , even though it would be desirable to detect and rehabilitate children with congenital hearing loss as early as possible ( incidence , 1-6 per 1000 ) . The Echosensor provides the means for carrying out OAE recordings within a short period of time and includes an automatic evaluation of results . Recordings can also be made by trained personnel . As a comparison test , audiologically trained staff recorded otoacoustic emissions in 111 newborn children in order to compare the results of the Echosensor with the results of a conventional OAE measurement device ( the ILO88). The aim of this pilot study was to determine the reliability and validity of the recordings in comparison with available standards in brainstem audiometry . Our study showed that the results of the Echosensor corresponded well with the ILO88 results . Consequently , an OAE measuring method is now available is also provides high sensitivity and specificity and is easy to use . Our findings show that the Echosensor can meet the demands of systematic hearing screening in Germany ."
],
"offsets": [
[
0,
1576
]
]
}
] |
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[] |
[] |
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HNO.80460944.eng.abstr
|
HNO.80460944.eng.abstr
|
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"A case report is presented of a 54-year-old woman with tinnitus synchronous with her pulse and an ipsilateral conductive hearing loss . Otoscopy showed a pulsatile structure behind the right eardrum . Imaging with high-resolution computed tomography of the temporal bone showed an enlarged jugular vein bulb . Magnetic resonance imaging could not be performed because of an implanted pacemaker . Since a glomus jugulare tumor could not be excluded right diagnostic tympanoscopy was performed and revealed a high jugular bulb that filled nearly a third of the tympanum ."
],
"offsets": [
[
0,
569
]
]
}
] |
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"Imaging"
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] |
[] |
[] |
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HNO.80460958.eng.abstr
|
HNO.80460958.eng.abstr
|
[
{
"id": "HNO.80460958.eng.abstr-passage-0",
"type": "abstract",
"text": [
"ENT specialists are now being asked for help by increasing numbers of snoring patients who complain about nocturnal apnea and excessive daytime sleepiness . A final diagnosis is often made in a sleep disorders center . Sleep medicine has emerged as a new interdisciplinary specialty during the last decade , although otorhinolaryngologists commonly are unable to fully interpret clinical findings . This report discusses the terms and information often detailed at a sleep disorders center . The evaluation of diagnostic and therapeutic procedures is explained ."
],
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[
0,
562
]
]
}
] |
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}
] |
[] |
[] |
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}
] |
HNO.80460986.eng.abstr
|
HNO.80460986.eng.abstr
|
[
{
"id": "HNO.80460986.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Starter's pistols are often bought for self-defense , but can also be used for criminal activities ( e.g. assaults , etc. ) . When a starter's pistol is loaded with blank cartridges and is fired , a powerful shooting noise results . The level of the noise produced is high enough to cause acoustic trauma . For legal examinations and giving an expert opinion further information is needed about the power of such noise . We examined how high peak sound pressure levels were of the gunshots of blank cartridges and whether there existed any directional characteristics from the noise emissions . In all , 15 different models of starter's pistols of 8 different calibres were examined . In addition to blank cartridges , 8 mm tear gas cartridges were also examined . Four transducers were situated in the horizontal plane around the muzzle : 0 ° ( shooting direction ) , 45 ° , 90 ° , and 180 ° ( towards the firer ) . The distances between the transducers and the muzzle were 25 cm , 50 cm , 100 cm , and 200 cm . At a distance of 1 m and in the 0 ° shooting direction the peak sound pressure levels of nearly all weapons tested exceeded 160 dB . At a shooting distance of 25 cm the peak sound pressure levels reached 181 dB . In addition , we observed a directional characteristic concerning the emission of noise : pistols produced higher peak sound pressure levels to the front than backwards towards the firer ."
],
"offsets": [
[
0,
1414
]
]
}
] |
[
{
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"Starter's"
],
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0,
9
]
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}
]
},
{
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"starter's"
],
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133,
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]
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}
] |
[] |
[] |
[
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}
] |
HNO.80460993.eng.abstr
|
HNO.80460993.eng.abstr
|
[
{
"id": "HNO.80460993.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Orbital pseudotumor can be divided histopathologically into three basic types : lymphoid , granulomatous and sclerosing . Chronic lymphoid and granulomatous types may eventually transform into the sclerosing type . The calcifying orbital pseudotumor is a very rare disorder due to a chronic , idiopathic inflammatory process of the orbit . The granulomatous type shows a good response to steroids while radiotherapy is the method of choice for lymphoid lesions . In general , calcifying pseudotumors can be treated only by operative exploration and tumor removal . We report a patient with a calcifying pseudotumor of the orbital apex that was removed through an endonasal approach . Preoperative diagnostic procedures and differential diagnosis are discussed ."
],
"offsets": [
[
0,
761
]
]
}
] |
[
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{
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"orbit"
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{
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{
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{
"id": "HNO.80460993.eng.abstr-s4-t3",
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{
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"choice"
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{
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{
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{
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"db_id": "C0220820"
},
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}
]
}
] |
[] |
[] |
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HNO.90470006.eng.abstr
|
HNO.90470006.eng.abstr
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[
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"Sonography has provided an important addition to the tools available for the diagnosis of the soft tissues in the head and neck region . The ENT surgeon himself is able to examine pathological formations by this quick , non-invasive and , last but not least , less expensive method . Due to the high resolution of the procedure the chance of detecting even small changes is increased and the exactness of diagnosis of pathological lymph nodes of the neck has been significantly improved compared to palpation alone . Ultrasound has replaced the sialographic procedures in the field of diagnostic evaluation of salivary gland disease in the daily practice except for special indications . After inauguration of color Doppler sonography non-invasive evaluation of vascular stenosis of the large cervical vessels concerning their hemodynamic effects has become possible . This issue is important for the differential dignosis of otoneurological diseases such as sudden hearing loss , vertigo and tinnitus . Additionally , the extent of perfusion of space-occupying lesions can be easily examined , and therefore the risk of mass bleeding can be preoperatively assessed by this method without harm to the patient . Especially carotid body tumors may be diagnosed with high accuracy by the evidence of significant diffuse perfusion of the lesion . In several studies the specificity of the assessment of cervical lymph node disease could be increased by examination of resistance indices . However , other authors have shown inconsistent results in differentiation of benign and malignant lumps ; therefore , final judgment does not seem to be possible yet . Use of echo-contrast agents to enhance the ultrasound signal seems to be a promising approach for future developments in color Doppler imaging ."
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[] |
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"arg2_id": "HNO.90470006.eng.abstr-s11-t4",
"normalized": []
},
{
"id": "HNO.90470006.eng.abstr-s11-r37-t5.1-t4.1",
"type": "occurs_in",
"arg1_id": "HNO.90470006.eng.abstr-s11-t5",
"arg2_id": "HNO.90470006.eng.abstr-s11-t4",
"normalized": []
}
] |
HNO.90470019.eng.abstr
|
HNO.90470019.eng.abstr
|
[
{
"id": "HNO.90470019.eng.abstr-passage-0",
"type": "abstract",
"text": [
"In the present study 220 patients suffering from recurrent rhinosinusitis and not responding to antibiotic treatment were evaluated for a defect in IgG-immunoglobulin subclasses . Twenty-one of these patients were found to have an antibody deficiency . These included deficiencies of IgG-2 ( n=10), IgG-1 ( n=6), IgG-3 ( n=1) and IgG-4 ( n=1). A common variable immune disease was diagnosed in three patients that was characterized by an additional defect in the IgG main class . However , an IgG subclass deficiency can only be ascertained by an immunological evaluation . The significance of a deficiency can be identified by a reaction to vaccination using ( for example ) protein or polysaccharide antigens . Treatment consists of antibiotics , intravenous immunoglobulins and long-term follow-up . Endonasal microsurgery should only be performed in cases that do not respond to conservative treatment . It is particularly necessary to observe these patients because a deficiency of immunoglobulin subclass in certain cases is the first sign of an immunological impairment that can advance to a severe immunodeficiency and predispose to the development of malignancy ."
],
"offsets": [
[
0,
1172
]
]
}
] |
[
{
"id": "HNO.90470019.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"patients"
],
"offsets": [
[
25,
33
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0030705"
}
]
},
{
"id": "HNO.90470019.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"antibiotic"
],
"offsets": [
[
96,
106
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0003232"
}
]
},
{
"id": "HNO.90470019.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"treatment"
],
"offsets": [
[
107,
116
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0087111"
},
{
"db_name": "UMLS",
"db_id": "C0039798"
}
]
},
{
"id": "HNO.90470019.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"defect"
],
"offsets": [
[
138,
144
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0243067"
}
]
},
{
"id": "HNO.90470019.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"patients"
],
"offsets": [
[
200,
208
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0030705"
}
]
},
{
"id": "HNO.90470019.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"antibody"
],
"offsets": [
[
231,
239
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0003241"
}
]
},
{
"id": "HNO.90470019.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"deficiency"
],
"offsets": [
[
240,
250
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0011155"
}
]
},
{
"id": "HNO.90470019.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"deficiencies"
],
"offsets": [
[
268,
280
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0011155"
}
]
},
{
"id": "HNO.90470019.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"disease"
],
"offsets": [
[
369,
376
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0012634"
}
]
},
{
"id": "HNO.90470019.eng.abstr-s3-t3",
"type": "umlsterm",
"text": [
"patients"
],
"offsets": [
[
400,
408
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0030705"
}
]
},
{
"id": "HNO.90470019.eng.abstr-s3-t4",
"type": "umlsterm",
"text": [
"defect"
],
"offsets": [
[
449,
455
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0243067"
}
]
},
{
"id": "HNO.90470019.eng.abstr-s3-t5",
"type": "umlsterm",
"text": [
"IgG"
],
"offsets": [
[
463,
466
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0020852"
}
]
},
{
"id": "HNO.90470019.eng.abstr-s4-t1",
"type": "umlsterm",
"text": [
"IgG"
],
"offsets": [
[
493,
496
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0020852"
}
]
},
{
"id": "HNO.90470019.eng.abstr-s4-t2",
"type": "umlsterm",
"text": [
"deficiency"
],
"offsets": [
[
506,
516
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0011155"
}
]
},
{
"id": "HNO.90470019.eng.abstr-s4-t3",
"type": "umlsterm",
"text": [
"evaluation"
],
"offsets": [
[
561,
571
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0220825"
}
]
},
{
"id": "HNO.90470019.eng.abstr-s5-t1",
"type": "umlsterm",
"text": [
"deficiency"
],
"offsets": [
[
596,
606
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0011155"
}
]
},
{
"id": "HNO.90470019.eng.abstr-s5-t2",
"type": "umlsterm",
"text": [
"vaccination"
],
"offsets": [
[
642,
653
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0042196"
}
]
},
{
"id": "HNO.90470019.eng.abstr-s5-t3",
"type": "umlsterm",
"text": [
"protein"
],
"offsets": [
[
676,
683
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0033684"
}
]
},
{
"id": "HNO.90470019.eng.abstr-s5-t4",
"type": "umlsterm",
"text": [
"polysaccharide"
],
"offsets": [
[
687,
701
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0032594"
}
]
},
{
"id": "HNO.90470019.eng.abstr-s5-t5",
"type": "umlsterm",
"text": [
"antigens"
],
"offsets": [
[
702,
710
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0003320"
}
]
},
{
"id": "HNO.90470019.eng.abstr-s6-t1",
"type": "umlsterm",
"text": [
"Treatment"
],
"offsets": [
[
713,
722
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0087111"
},
{
"db_name": "UMLS",
"db_id": "C0039798"
}
]
},
{
"id": "HNO.90470019.eng.abstr-s6-t2",
"type": "umlsterm",
"text": [
"antibiotics"
],
"offsets": [
[
735,
746
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0003232"
}
]
},
{
"id": "HNO.90470019.eng.abstr-s6-t3",
"type": "umlsterm",
"text": [
"immunoglobulins"
],
"offsets": [
[
761,
776
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0021027"
}
]
},
{
"id": "HNO.90470019.eng.abstr-s6-t4",
"type": "umlsterm",
"text": [
"intravenous immunoglobulins"
],
"offsets": [
[
749,
776
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0085297"
}
]
},
{
"id": "HNO.90470019.eng.abstr-s7-t1",
"type": "umlsterm",
"text": [
"microsurgery"
],
"offsets": [
[
813,
825
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0026035"
}
]
},
{
"id": "HNO.90470019.eng.abstr-s7-t2",
"type": "umlsterm",
"text": [
"treatment"
],
"offsets": [
[
896,
905
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0087111"
},
{
"db_name": "UMLS",
"db_id": "C0039798"
}
]
},
{
"id": "HNO.90470019.eng.abstr-s8-t1",
"type": "umlsterm",
"text": [
"patients"
],
"offsets": [
[
954,
962
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0030705"
}
]
},
{
"id": "HNO.90470019.eng.abstr-s8-t2",
"type": "umlsterm",
"text": [
"deficiency"
],
"offsets": [
[
973,
983
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0011155"
}
]
},
{
"id": "HNO.90470019.eng.abstr-s8-t3",
"type": "umlsterm",
"text": [
"immunoglobulin"
],
"offsets": [
[
987,
1001
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0021027"
}
]
},
{
"id": "HNO.90470019.eng.abstr-s8-t4",
"type": "umlsterm",
"text": [
"sign"
],
"offsets": [
[
1041,
1045
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0220912"
}
]
},
{
"id": "HNO.90470019.eng.abstr-s8-t5",
"type": "umlsterm",
"text": [
"immunodeficiency"
],
"offsets": [
[
1106,
1122
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0021051"
}
]
},
{
"id": "HNO.90470019.eng.abstr-s8-t6",
"type": "umlsterm",
"text": [
"development"
],
"offsets": [
[
1145,
1156
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0243107"
},
{
"db_name": "UMLS",
"db_id": "C0020119"
}
]
},
{
"id": "HNO.90470019.eng.abstr-s8-t7",
"type": "umlsterm",
"text": [
"malignancy"
],
"offsets": [
[
1160,
1170
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0006826"
}
]
}
] |
[] |
[] |
[
{
"id": "HNO.90470019.eng.abstr-s1-r1-t3.1-t1.1",
"type": "affects",
"arg1_id": "HNO.90470019.eng.abstr-s8-t3",
"arg2_id": "HNO.90470019.eng.abstr-s8-t1",
"normalized": []
},
{
"id": "HNO.90470019.eng.abstr-s1-r2-t1.1-t3.1",
"type": "performs",
"arg1_id": "HNO.90470019.eng.abstr-s8-t1",
"arg2_id": "HNO.90470019.eng.abstr-s8-t3",
"normalized": []
},
{
"id": "HNO.90470019.eng.abstr-s1-r3-t3.1-t2.1",
"type": "uses",
"arg1_id": "HNO.90470019.eng.abstr-s8-t3",
"arg2_id": "HNO.90470019.eng.abstr-s8-t2",
"normalized": []
},
{
"id": "HNO.90470019.eng.abstr-s3-r1-t4.1-t1.1",
"type": "indicates",
"arg1_id": "HNO.90470019.eng.abstr-s8-t4",
"arg2_id": "HNO.90470019.eng.abstr-s8-t1",
"normalized": []
},
{
"id": "HNO.90470019.eng.abstr-s3-r2-t1.1-t3.1",
"type": "occurs_in",
"arg1_id": "HNO.90470019.eng.abstr-s8-t1",
"arg2_id": "HNO.90470019.eng.abstr-s8-t3",
"normalized": []
},
{
"id": "HNO.90470019.eng.abstr-s3-r3-t1.1-t4.1",
"type": "produces",
"arg1_id": "HNO.90470019.eng.abstr-s8-t1",
"arg2_id": "HNO.90470019.eng.abstr-s8-t4",
"normalized": []
},
{
"id": "HNO.90470019.eng.abstr-s3-r4-t4.1-t1.1",
"type": "affects",
"arg1_id": "HNO.90470019.eng.abstr-s8-t4",
"arg2_id": "HNO.90470019.eng.abstr-s8-t1",
"normalized": []
},
{
"id": "HNO.90470019.eng.abstr-s4-r1-t3.1-t1.1",
"type": "measures",
"arg1_id": "HNO.90470019.eng.abstr-s8-t3",
"arg2_id": "HNO.90470019.eng.abstr-s8-t1",
"normalized": []
},
{
"id": "HNO.90470019.eng.abstr-s5-r1-t3.1-t4.1",
"type": "interacts_with",
"arg1_id": "HNO.90470019.eng.abstr-s8-t3",
"arg2_id": "HNO.90470019.eng.abstr-s8-t4",
"normalized": []
},
{
"id": "HNO.90470019.eng.abstr-s5-r2-t5.1-t4.1",
"type": "interacts_with",
"arg1_id": "HNO.90470019.eng.abstr-s8-t5",
"arg2_id": "HNO.90470019.eng.abstr-s8-t4",
"normalized": []
},
{
"id": "HNO.90470019.eng.abstr-s5-r3-t1.1-t4.1",
"type": "uses",
"arg1_id": "HNO.90470019.eng.abstr-s8-t1",
"arg2_id": "HNO.90470019.eng.abstr-s8-t4",
"normalized": []
},
{
"id": "HNO.90470019.eng.abstr-s5-r4-t4.1-t5.1",
"type": "interacts_with",
"arg1_id": "HNO.90470019.eng.abstr-s8-t4",
"arg2_id": "HNO.90470019.eng.abstr-s8-t5",
"normalized": []
},
{
"id": "HNO.90470019.eng.abstr-s5-r5-t5.1-t3.1",
"type": "interacts_with",
"arg1_id": "HNO.90470019.eng.abstr-s8-t5",
"arg2_id": "HNO.90470019.eng.abstr-s8-t3",
"normalized": []
},
{
"id": "HNO.90470019.eng.abstr-s5-r6-t3.1-t5.1",
"type": "interacts_with",
"arg1_id": "HNO.90470019.eng.abstr-s8-t3",
"arg2_id": "HNO.90470019.eng.abstr-s8-t5",
"normalized": []
},
{
"id": "HNO.90470019.eng.abstr-s5-r7-t4.1-t3.1",
"type": "interacts_with",
"arg1_id": "HNO.90470019.eng.abstr-s8-t4",
"arg2_id": "HNO.90470019.eng.abstr-s8-t3",
"normalized": []
},
{
"id": "HNO.90470019.eng.abstr-s6-r1-t3.1-t4.1",
"type": "interacts_with",
"arg1_id": "HNO.90470019.eng.abstr-s8-t3",
"arg2_id": "HNO.90470019.eng.abstr-s8-t4",
"normalized": []
},
{
"id": "HNO.90470019.eng.abstr-s6-r2-t1.1-t3.1",
"type": "uses",
"arg1_id": "HNO.90470019.eng.abstr-s8-t1",
"arg2_id": "HNO.90470019.eng.abstr-s8-t3",
"normalized": []
},
{
"id": "HNO.90470019.eng.abstr-s6-r3-t4.1-t1.1",
"type": "interacts_with",
"arg1_id": "HNO.90470019.eng.abstr-s8-t4",
"arg2_id": "HNO.90470019.eng.abstr-s8-t1",
"normalized": []
},
{
"id": "HNO.90470019.eng.abstr-s6-r4-t1.1-t4.1",
"type": "uses",
"arg1_id": "HNO.90470019.eng.abstr-s8-t1",
"arg2_id": "HNO.90470019.eng.abstr-s8-t4",
"normalized": []
},
{
"id": "HNO.90470019.eng.abstr-s6-r5-t3.1-t1.1",
"type": "interacts_with",
"arg1_id": "HNO.90470019.eng.abstr-s8-t3",
"arg2_id": "HNO.90470019.eng.abstr-s8-t1",
"normalized": []
},
{
"id": "HNO.90470019.eng.abstr-s6-r6-t1.1-t4.1",
"type": "interacts_with",
"arg1_id": "HNO.90470019.eng.abstr-s8-t1",
"arg2_id": "HNO.90470019.eng.abstr-s8-t4",
"normalized": []
},
{
"id": "HNO.90470019.eng.abstr-s6-r7-t4.1-t3.1",
"type": "interacts_with",
"arg1_id": "HNO.90470019.eng.abstr-s8-t4",
"arg2_id": "HNO.90470019.eng.abstr-s8-t3",
"normalized": []
},
{
"id": "HNO.90470019.eng.abstr-s6-r8-t1.1-t3.1",
"type": "interacts_with",
"arg1_id": "HNO.90470019.eng.abstr-s8-t1",
"arg2_id": "HNO.90470019.eng.abstr-s8-t3",
"normalized": []
},
{
"id": "HNO.90470019.eng.abstr-s8-r1-t2.1-t4.1",
"type": "affects",
"arg1_id": "HNO.90470019.eng.abstr-s8-t2",
"arg2_id": "HNO.90470019.eng.abstr-s8-t4",
"normalized": []
},
{
"id": "HNO.90470019.eng.abstr-s8-r2-t2.1-t7.1",
"type": "affects",
"arg1_id": "HNO.90470019.eng.abstr-s8-t2",
"arg2_id": "HNO.90470019.eng.abstr-s8-t7",
"normalized": []
},
{
"id": "HNO.90470019.eng.abstr-s8-r3-t4.1-t6.1",
"type": "evaluation_of",
"arg1_id": "HNO.90470019.eng.abstr-s8-t4",
"arg2_id": "HNO.90470019.eng.abstr-s8-t6",
"normalized": []
},
{
"id": "HNO.90470019.eng.abstr-s8-r4-t7.1-t4.1",
"type": "degree_of",
"arg1_id": "HNO.90470019.eng.abstr-s8-t7",
"arg2_id": "HNO.90470019.eng.abstr-s8-t4",
"normalized": []
},
{
"id": "HNO.90470019.eng.abstr-s8-r5-t2.1-t4.1",
"type": "indicates",
"arg1_id": "HNO.90470019.eng.abstr-s8-t2",
"arg2_id": "HNO.90470019.eng.abstr-s8-t4",
"normalized": []
},
{
"id": "HNO.90470019.eng.abstr-s8-r6-t2.1-t4.1",
"type": "diagnoses",
"arg1_id": "HNO.90470019.eng.abstr-s8-t2",
"arg2_id": "HNO.90470019.eng.abstr-s8-t4",
"normalized": []
},
{
"id": "HNO.90470019.eng.abstr-s8-r7-t7.1-t6.1",
"type": "result_of",
"arg1_id": "HNO.90470019.eng.abstr-s8-t7",
"arg2_id": "HNO.90470019.eng.abstr-s8-t6",
"normalized": []
},
{
"id": "HNO.90470019.eng.abstr-s8-r8-t2.1-t6.1",
"type": "affects",
"arg1_id": "HNO.90470019.eng.abstr-s8-t2",
"arg2_id": "HNO.90470019.eng.abstr-s8-t6",
"normalized": []
},
{
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] |
HNO.90470025.eng.abstr
|
HNO.90470025.eng.abstr
|
[
{
"id": "HNO.90470025.eng.abstr-passage-0",
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"text": [
"Background : To determine the applicability of alloplastic materials as bone substitutes it is now standard procedure to test materials for possible toxic effects and to study their behavior in animal models and cell cultures . This is especially important with respect to middle ear implants that can be put at risk by recurrent infections and require additional testing in a bacterially contaminated environment ."
],
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[
0,
415
]
]
}
] |
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]
}
] |
[] |
[] |
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{
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] |
HNO.90470033.eng.abstr
|
HNO.90470033.eng.abstr
|
[
{
"id": "HNO.90470033.eng.abstr-passage-0",
"type": "abstract",
"text": [
"It is now well known that chronic alcohol abuse is an important factor for developing head and neck squamous cell carcinoma ( HNSCC ) . While hospitalized , these patients are at great risk for developing an unexpected alcohol-withdrawal syndrome . Compared to common markers of alcohol abuse , carbohydrate-deficient transferrin ( CDT ) has been found to be more sensitive and specific . It is therefore very useful for detecting alcoholism and controlling compliance of alcohol withdrawal . We analyzed the serum concentrations of CDT , liver enzymes and mean corpuscular volume in 49 male patients with HNSCC . Elevated CDT levels were found in more than 25% of patients who earlier denied a history of chronic alcohol abuse . Over one-third of these patients developed an alcohol-withdrawal syndrome . These findings demonstrated that analysis of elevated CDT serum levels was a valuable method for detecting chronic alcohol abuse and recognizing patients at risk for developing an alcohol-withdrawal syndrome postoperatively ."
],
"offsets": [
[
0,
1031
]
]
}
] |
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{
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"neck"
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{
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"cell"
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{
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},
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},
{
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]
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"patients"
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]
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}
]
},
{
"id": "HNO.90470033.eng.abstr-s2-t2",
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"risk"
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]
],
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}
]
},
{
"id": "HNO.90470033.eng.abstr-s2-t3",
"type": "umlsterm",
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"alcohol-withdrawal"
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{
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]
},
{
"id": "HNO.90470033.eng.abstr-s3-t1",
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"markers"
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},
{
"id": "HNO.90470033.eng.abstr-s3-t2",
"type": "umlsterm",
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"alcohol"
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]
},
{
"id": "HNO.90470033.eng.abstr-s3-t3",
"type": "umlsterm",
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"abuse"
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]
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]
},
{
"id": "HNO.90470033.eng.abstr-s3-t4",
"type": "umlsterm",
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"carbohydrate-deficient"
],
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295,
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]
},
{
"id": "HNO.90470033.eng.abstr-s3-t5",
"type": "umlsterm",
"text": [
"transferrin"
],
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},
{
"id": "HNO.90470033.eng.abstr-s3-t6",
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"CDT"
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{
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]
},
{
"id": "HNO.90470033.eng.abstr-s3-t8",
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{
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{
"id": "HNO.90470033.eng.abstr-s4-t3",
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},
{
"id": "HNO.90470033.eng.abstr-s5-t1",
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"concentrations"
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{
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{
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{
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"male"
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{
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{
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},
{
"id": "HNO.90470033.eng.abstr-s8-t11",
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],
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{
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}
]
}
] |
[] |
[] |
[
{
"id": "HNO.90470033.eng.abstr-s1-r1-t2.1-t7.1",
"type": "location_of",
"arg1_id": "HNO.90470033.eng.abstr-s8-t2",
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},
{
"id": "HNO.90470033.eng.abstr-s1-r2-t6.1-t7.1",
"type": "degree_of",
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"arg2_id": "HNO.90470033.eng.abstr-s8-t7",
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},
{
"id": "HNO.90470033.eng.abstr-s1-r3-t2.1-t6.1",
"type": "location_of",
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"arg2_id": "HNO.90470033.eng.abstr-s8-t6",
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},
{
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] |
HNO.90470038.eng.abstr
|
HNO.90470038.eng.abstr
|
[
{
"id": "HNO.90470038.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Screening for distant metastases from head and neck tumors is still controversial . In the present study , the records of 1087 patients with newly diagnosed squamous cell carcinomas of the upper aerodigestive tract were reviewed retrospectively to determine clinical factors influencing the incidence and location of distant metastases . Overall , 130 patients ( 12.0% ) developed clinical evidence of metastatic disease , 17 of whom ( 1.6% ) had metastases at the time of initial presentation . The rate of distant metastases significantly increased with the initial stage of tumors ( P 0.00001 ) and the occurrence of local and/or regional recurrences ( P 0.00001 ) or of second primaries below the clavicles ( P 0.0005 ) . The locations of primary cancers as well as histopathologic grading were not independent risk factors for the development of distant metastases . They mainly reflected different frequency distributions of stages . The lungs , liver and bones were the most common sites of metastatic disease , being involved in 68.5% , 23.8% and 20.0% of cases , respectively . Our findings show that at the time of initial presentation chest X-ray alone appears to be sufficient to exclude distant metastases from tumors classified as T1-3 N0. Further screening comprising abdominal ultrasound , bone scanning and/or CT scans of the thorax is particularly indicated for patients with advanced-stage disease , local and/or regional recurrences and second primaries below the clavicles . However , the individual decisions should consider whether the detection of distant metastases will significantly affect clinical management ."
],
"offsets": [
[
0,
1638
]
]
}
] |
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] |
[] |
[] |
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HNO.90470045.eng.abstr
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HNO.90470045.eng.abstr
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"The importance of the neurobiological basis of developmental language disorders includes somatosensory modalities . Twenty-five children were diagnosed as having specific language-impairment at preschool age . All were examined with regard to their manual haptic form discrimination without visual control at a mean age of 8.7 years +/- 7.1 months . This study group was compared to age- and gender-matched normal children of equal non-verbal intelligence ( control group ) . Haptic discrimination was measured with the Seguin formboard on which the children were required to place ten geometrical forms in appropriate holes . Both groups differed significantly in their mean quantitative performances in favor of the control group ( P 0.05 ) . The difference in their mean performance and their mean discrimination times did not reach statistical significance . All results were not age-dependent . The control group on average performed significantly better with their left hands than the study group ( P 0.05 ) . Qualitative analysis revealed a significant difference in haptic discrimination of the pointed forms and was probably caused by inadequate exploration procedures and/or cognitive representation deficits . The results of the children with previous developmental language disorders were interpreted as an expression of an impaired cerebral maturation ."
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[] |
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] |
HNO.90470051.eng.abstr
|
HNO.90470051.eng.abstr
|
[
{
"id": "HNO.90470051.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Extracranial meningiomas are rare tumors of the lateral skull base . A 37-year-old woman presented with tinnitus und progressive hearing loss of her right ear . A painful mass lesion was also palpable in her mandibular angle . CT and MRI scans revealed an intracranial mass with extension to the lateral skull base . These findings suggested the occurrence of a paraganglioma or meningioma . In a two-stage surgical procedure tumor was extirpated without functional impairment to the patient . Histology of the excised lesion demonstrated an endotheliomatous meningioma . Since an extracranial meningioma can present as a mass lesion of the lateral skull base , CT and MRI scans are essential in preoperative surgical planning ."
],
"offsets": [
[
0,
728
]
]
}
] |
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[] |
[] |
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] |
HNO.90470101.eng.abstr
|
HNO.90470101.eng.abstr
|
[
{
"id": "HNO.90470101.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The erbium : YAG laser ( wavelength 2940 nm ; pulse duration 0.350 ms ; pulse energy 0.1-1.7 J ) allows vaporization of very thin skin layers without scarring and minimal lateral thermal injury due to an extremely short pulse duration . It permits exact ablation of relatively large areas of facial skin . We report our results with 216 patients following treatment for different facial lesions ( facial wrinkles , acne scars , syringomas , and circumscribed sebaceous gland hyperplasia ) using a new erbium : YAG laser system . Good-to-excellent cosmetic results were obtained in these patients . Our findings show that the erbium : YAG laser is an elegant and promising new method for the treatment of facial lesions ."
],
"offsets": [
[
0,
720
]
]
}
] |
[
{
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],
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4,
10
]
],
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{
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],
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17,
22
]
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[] |
[] |
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HNO.90470107.eng.abstr
|
HNO.90470107.eng.abstr
|
[
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"type": "abstract",
"text": [
"Otorrhea is the most common complication after tympanostomy tube insertions . In Germany there are currently two commonly used types of tympanostomy tubes : silicon tubes ( ST ) and gilded silver tubes ( GT ) . Previously published in vitro studies by Tajima uncovered a positive correlation between the silicon concentration in culture fluid and the rate of growth of Staphylococcus aureus . Our study retrospectively evaluates the types of bacteria and rates of otorrhea after ST and GT insertions . The present study was undertaken to determine which of these tubes had a higher incidence of otorrhea and then whether silicon tubes stimulated the growth of certain types of bacteria , such as Staphylococcus aureus . In all , 186 ST and 59 GT were placed in 245 ears of 144 children . Both ST and GT were separated into three groups : first insertion of a tympanostomy tube , second implantation and insertion of a tympanostomy tube in an infected ear in the course of a mastoidectomy . No differences between ST and GT in causing otorrhea were found in the three groups . Nevertheless , ST in comparison to GT was associated with a higher incidence of infections with Pseudomonas aeruginosa . In contrast , a higher incidence of Staphylococcus aureus related to ST could not be proved . Twenty percent of the ears with mastoiditis were found to have Pseudomonas aeruginosa , but none of these ears implanted with a GT developed postoperative otorrhea . Our findings show that GT should be used when a ventilation tube is used during a mastoidectomy . Further , it is tenable to implant only GT because postoperative otorrhea in many cases is caused by insufficient water protection and water isfrequently polluted with Pseudomonas aeruginosa ."
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] |
[] |
[] |
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] |
HNO.90470112.eng.abstr
|
HNO.90470112.eng.abstr
|
[
{
"id": "HNO.90470112.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Monitoring of pH of the esophagus is a routine diagnostic procedure , whereas until now pH-monitoring of the hypopharynx has been used only for scientific research . In the present study a critical evaluation scale was used to record the results of 112 patients who underwent pH monitoring to determine possible reflux . Since high refluxes often remain unnoticed clinically , further study is required in certain cases . The extent of reflux in the esophagus may not represent pathological changes in the hypopharynx . In such cases 24-h pH monitoring of the hypopharynx can be a useful diagnostic procedure and may also help detect the pathogenesis of \" gastric laryngitis \" ."
],
"offsets": [
[
0,
678
]
]
}
] |
[
{
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],
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10
]
],
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}
]
},
{
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"esophagus"
],
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24,
33
]
],
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{
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}
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{
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47,
57
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{
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"procedure"
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{
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109,
120
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{
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{
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{
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"patients"
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253,
261
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}
]
},
{
"id": "HNO.90470112.eng.abstr-s4-t1",
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"text": [
"esophagus"
],
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450,
459
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},
{
"id": "HNO.90470112.eng.abstr-s4-t2",
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]
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{
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{
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},
{
"id": "HNO.90470112.eng.abstr-s5-t3",
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}
]
},
{
"id": "HNO.90470112.eng.abstr-s5-t4",
"type": "umlsterm",
"text": [
"pathogenesis"
],
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[
638,
650
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],
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]
},
{
"id": "HNO.90470112.eng.abstr-s5-t5",
"type": "umlsterm",
"text": [
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664,
674
]
],
"normalized": [
{
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"db_id": "C0023067"
}
]
}
] |
[] |
[] |
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HNO.90470117.eng.abstr
|
HNO.90470117.eng.abstr
|
[
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"Multiple-system atrophy ( MSA ) is characterized by progressive autonomic failure with cerebellar , pyramidal and extrapyramidal signs . In MSA patients laryngoscopy often reveals unilateral or bilateral abductor vocal fold palsies . Snoring is very common . However , assessment of sites of obstruction and their severity is needed . We report our clinical experience in managing a 56-year-old, obese male MSA patient ( 1.76 m height , 100 kg weight , BMI 32.3 kg/m2) who was admitted for evaluation of snoring and excessive daytime sleepiness . Endoscopy while awake demonstrated an incomplete abductor vocal fold palsy . Polysomnography confirmed heavy snoring with arousals ( 11.1/h) and an RDI of 1.4/h. Sleep efficiency was low ( 51.9% ) due to long intermittent awake periods . Sleep videoendoscopy of the upper airway proved the entire pharynx to be open during REM and non-REM sleep . During inspiration fluttering movements of the vocal cords caused the snoring . This was regularly terminated by arousals . The further treatment is discussed . In general , glottic snoring without daytime stridor is rare and has only been described in MSA patients . However , certain of these patients will also be pharyngeal snorers . The source of the sound and site of obstruction can only be diagnosed by sleep videoendoscopy ."
],
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[] |
[] |
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] |
HNO.90470122.eng.abstr
|
HNO.90470122.eng.abstr
|
[
{
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"type": "abstract",
"text": [
"Between May 1995 and March 1996 we were able to diagnose and remove glomus tumors of the left nasal cavity from three female patients . Ages of the patients were 9 , 36 and 74 years . All patients suffered from a frequent epistaxis and all were extremely sensitive to the slightest nasal touch . One patient reported breathing difficulties due to nasal congestion . Examination revealed a tumor that filled the entire nasal cavity . The method of choice in treatment of these tumors is surgical removal . Hemangiopericytoma , non-chromaffin paraganglioma , hidradenoma , cavernous hemangioma and nevus cell nevi have to be excluded by histology and immunohistochemical techniques . From a clinical perspective the bleeding septal polyp ( granuloma telangiectaticum sive pyogenicum sive pediculatum ) has to be considered because it often comes from Kieselbachi's plexus , has a mushroom-like appearance and bleeds slightly ."
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] |
[] |
[] |
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HNO.90470157.eng.abstr
|
HNO.90470157.eng.abstr
|
[
{
"id": "HNO.90470157.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Cystic fibrosis ( CF ) is the most commonly inherited disease in Caucasians and is caused by a mutation in the gene encoding a membrane transport protein . This cystic fibrosis transmembrane conductance regulator ( CFTR ) is thought to be an apical Cl- channel activated by intracellular cAMP . Most recent findings suggest that CFTR is more than a pure Cl- channel and might be involved in the regulation of other transport systems . In the present study we show that CFTR as a Cl- channel plays only a minor role in primary cultured human nasal epithelium derived from non-CF and CF patients . These findings are especially of interest for non-CF human nasal epithelia in which CFTR is correctly inserted . In both tissues Cl- secretion is negligible as compared with Na+ absorption . We confirm and expand our previous observations that Na+ absorption in human nasal epithelium is the dominant ion transport process and that Cl- secretion is detectable in both CF and non-CF tissue . Moreover , we show that cAMP and ATP were not able to stimulate any silent Cl- channels in CF or non-CF human nasal epithelial cells . We further give evidence that in human nasal CF and non-CF epithelium Na+ absorption is mediated by epithelial Na+ channels ( ENaC ) that are either different from those of other epithelia or which exhibit altered regulation . These differences between Na+ channels of human nasal epithelium and \" classical \" epithelial Na+ channels include lack of activation by the intracellular second messenger cAMP and the steroid hormone aldosterone . We show further that human nasal Na+ channels are inhibited by Cl--channel blockers and exhibit a different pharmacology towards common Na+ channel blockers ."
],
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[
0,
1722
]
]
}
] |
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] |
[] |
[] |
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] |
HNO.90470167.eng.abstr
|
HNO.90470167.eng.abstr
|
[
{
"id": "HNO.90470167.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Dysphagia is a common complaint following surgical intervention in the oral cavity and hypopharynx , often leading to prolonged postoperative recovery . Videofluoroscopy allows detailed visualization of deglutition , demonstrating the morphology as well as the functional aspects . Therefore , videofluoroscopy provides the basis for further therapeutic management . We discuss the pathology of deglutition in 19 patients recovering from tumor surgery of the oro- and hypopharynx . In most cases the results demonstrated severe impairment of both the oral and pharyngeal phase of deglutition . Our data emphasize the importance of the oral phase of deglutition for preparation and initiation of the following phases ."
],
"offsets": [
[
0,
717
]
]
}
] |
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{
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{
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{
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{
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{
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{
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649,
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]
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]
}
] |
[] |
[] |
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}
] |
HNO.90470172.eng.abstr
|
HNO.90470172.eng.abstr
|
[
{
"id": "HNO.90470172.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The importance of spiral-CT is clinically accepted for diagnosing spreading disease and for making a decision about the therapy strategy for head and neck tumors . Its importance for follow-up after radiotherapy was examined in 26 patients with irradiated laryngeal tumors . Using spiral-CT multiple signs of alterations ( n=98) can be diagnosed , which are not only important for tumour relapse , but also for assessment . Spiral-CT offers the possibility of achieviny various additional information about the larynx that cannot be obtained with laryngoscopy . In follow-up examinations after radiation , laryngoscopy and spiral-CT are recommended as an integrated neck examination using the breath-holding technique ( separately reconstructed ) and also as functional spiral-CT of the vocal cords in \" I \" -phonation ."
],
"offsets": [
[
0,
820
]
]
}
] |
[
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{
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],
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]
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]
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{
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"head"
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{
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]
},
{
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],
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{
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{
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{
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{
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"tumors"
],
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266,
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]
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{
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"signs"
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]
},
{
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"tumour"
],
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]
},
{
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{
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]
},
{
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]
},
{
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{
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},
{
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},
{
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}
]
},
{
"id": "HNO.90470172.eng.abstr-s5-t5",
"type": "umlsterm",
"text": [
"-phonation"
],
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[
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]
],
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{
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"db_id": "C0031577"
}
]
},
{
"id": "HNO.90470172.eng.abstr-s5-t6",
"type": "umlsterm",
"text": [
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],
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]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0042930"
}
]
}
] |
[] |
[] |
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HNO.90470183.eng.abstr
|
HNO.90470183.eng.abstr
|
[
{
"id": "HNO.90470183.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Hemangiopericytomas are mesenchymal tumors and account for about 1% of all CNS tumors . Aggressive growth , tendency to local recurrence and relatively frequent metastases are the clinical features of these tumors . Histological characteristics are marked cellularity , vascularity and a dense net of reticular fibers . This case presents a patient with a local recurrence of a right temporal , atypical meningioma that had been operated on and irradiated elsewhere . After embolization large parts of the tumor were removed palliatively . Histological aspects of the resected tumor were consistent with a diagnosis of an atypical meningioma . Not until hepatic metastases from this tumor were found was the diagnosis re-examined and corrected to a malignant meningeal hemangopericytoma . Surgical resection of primary tumor with frequent controls and , if needed , postoperative radiation therapy is the treatment of choice . Furthermore metastasizing atypical meningiomas should be examined critically to determine if a hemangiopericytoma is present ."
],
"offsets": [
[
0,
1053
]
]
}
] |
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] |
[] |
[] |
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] |
HNO.90470192.eng.abstr
|
HNO.90470192.eng.abstr
|
[
{
"id": "HNO.90470192.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The posterior orbit contain's a number of important and vulnerable structures , including the optic nerve , the opthalmic artery and vein , the ocular muscles and their motor nerves . Because of their close relation to the ocular bult , surgical access to this region is very difficult . Transfrontal , transfrontalethmoidal and transmaxillary procedures have the disadvantage of possible injury to a number of non-tumor affected structures . The endonasal microsurgical transethmoid access is described here along with a case report of a 2x1 cm intraconal hemangioma . Ethmoidectomy was performed after septal mobilization . The optic nerve was identified in the wall of the sphenoid sinus . The lamina papyracea was resected between the sphenoid sinus wall , skull base and ethmoid . The medial rectus muscle was mobilized after slitting open the periorbita to expose tumor . The hemangioma was then removed in toto under microscopic control . Surgery in the retrobulbar region could be performed gently and under microscopic magnification with this technique . The procedure used has a minor risk in the hands of an experienced nasalsurgeon and opens up new possibilities for the treatment of retroorbital lesions ."
],
"offsets": [
[
0,
1218
]
]
}
] |
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HNO.90470226.eng.abstr
|
HNO.90470226.eng.abstr
|
[
{
"id": "HNO.90470226.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Before the invention of CPAP therapy , the only effective surgical treatment for obstructive sleep apnea syndrome was tracheotomy . Now , surgical approaches mainly focus on two anatomical sites . Each procedure influences either the retropalatal or retrolingual portion of the pharynx . They might be applied individually , synchronously with other procedures , or sequentially with other therapeutic devices . Common methods of velar surgery include uvulopalatopharyngoplasty ( UPPP ) , Laser-assisted uvuloplasty ( LAUP ) , radiofrequency or uvulaflap . These techniques are indicated mainly in patients with mild OSAS . Other procedures focus on the posterior airway space ( PAS ) , including operations that reduce the volume of the tongue or base of tongue . In selected patients , an enlargement of the retrolingual airway is gained by osteosynthetic techniques . Improvement of the nasal airway passage is gained by performing a septoplasty and/or conchotomy . In this paper , the different methods and their indications for surgical therapy will be explained and the results are summarized ."
],
"offsets": [
[
0,
1100
]
]
}
] |
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] |
[] |
[] |
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] |
HNO.90470236.eng.abstr
|
HNO.90470236.eng.abstr
|
[
{
"id": "HNO.90470236.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Although noise in general can induce hearing loss , environmental noise represents an important risk for children , teenagers and young adults . Epidemiological investigations now support the occurrence of an increasing number of irreversible hearing losses in these groups . Major causes of hearing loss are toys ( guns ) , explosives and electroacoustically amplified music delivered by head sets or heard in discotheques and open air concerts . Clinical indications are discussed ."
],
"offsets": [
[
0,
484
]
]
}
] |
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243,
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}
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},
{
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],
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243,
257
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},
{
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]
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},
{
"id": "HNO.90470236.eng.abstr-s3-t3",
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{
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],
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},
{
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[] |
[] |
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] |
HNO.90470249.eng.abstr
|
HNO.90470249.eng.abstr
|
[
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"Purpose : For some time , the ambulatory diagnosis of sleep-related breathing disorders has included the use of seven-channel recording units . One such unit is the POLY-MESAM ( MAP , Martinsried , FRG ) . The first part of the present study prospectively investigated the handling of the system for physicians and patients , its technical reliability , reliability of the software used and the results in comparison to handscoring ."
],
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[
0,
433
]
]
}
] |
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] |
[] |
[] |
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"arg2_id": "HNO.90470249.eng.abstr-s1-t5",
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},
{
"id": "HNO.90470249.eng.abstr-s2-r1-t2.2-t1.1",
"type": "interacts_with",
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"arg2_id": "HNO.90470249.eng.abstr-s3-t1",
"normalized": []
},
{
"id": "HNO.90470249.eng.abstr-s2-r2-t1.1-t2.2",
"type": "interacts_with",
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"arg2_id": "HNO.90470249.eng.abstr-s2-t2",
"normalized": []
},
{
"id": "HNO.90470249.eng.abstr-s3-r1-t4.1-t2.1",
"type": "associated_with",
"arg1_id": "HNO.90470249.eng.abstr-s3-t4",
"arg2_id": "HNO.90470249.eng.abstr-s3-t2",
"normalized": []
},
{
"id": "HNO.90470249.eng.abstr-s3-r2-t1.1-t4.1",
"type": "performs",
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"arg2_id": "HNO.90470249.eng.abstr-s3-t4",
"normalized": []
},
{
"id": "HNO.90470249.eng.abstr-s3-r3-t4.1-t1.1",
"type": "associated_with",
"arg1_id": "HNO.90470249.eng.abstr-s3-t4",
"arg2_id": "HNO.90470249.eng.abstr-s3-t1",
"normalized": []
},
{
"id": "HNO.90470249.eng.abstr-s3-r4-t2.1-t3.1",
"type": "uses",
"arg1_id": "HNO.90470249.eng.abstr-s3-t2",
"arg2_id": "HNO.90470249.eng.abstr-s3-t3",
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},
{
"id": "HNO.90470249.eng.abstr-s3-r5-t1.1-t3.1",
"type": "uses",
"arg1_id": "HNO.90470249.eng.abstr-s3-t1",
"arg2_id": "HNO.90470249.eng.abstr-s3-t3",
"normalized": []
},
{
"id": "HNO.90470249.eng.abstr-s3-r6-t2.1-t4.1",
"type": "performs",
"arg1_id": "HNO.90470249.eng.abstr-s3-t2",
"arg2_id": "HNO.90470249.eng.abstr-s3-t4",
"normalized": []
},
{
"id": "HNO.90470249.eng.abstr-s3-r7-t1.1-t2.1",
"type": "treats",
"arg1_id": "HNO.90470249.eng.abstr-s3-t1",
"arg2_id": "HNO.90470249.eng.abstr-s3-t2",
"normalized": []
},
{
"id": "HNO.90470249.eng.abstr-s3-r8-t2.1-t1.1",
"type": "interacts_with",
"arg1_id": "HNO.90470249.eng.abstr-s3-t2",
"arg2_id": "HNO.90470249.eng.abstr-s3-t1",
"normalized": []
}
] |
HNO.90470256.eng.abstr
|
HNO.90470256.eng.abstr
|
[
{
"id": "HNO.90470256.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Purpose : For some time , the ambulatory diagnosis of respiratory disturbances during sleep has included the use of seven-channel recording units . One of these systems is the POLY-MESAM unit ( MAP , Germany ) ."
],
"offsets": [
[
0,
211
]
]
}
] |
[
{
"id": "HNO.90470256.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"time"
],
"offsets": [
[
19,
23
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0040223"
}
]
},
{
"id": "HNO.90470256.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"diagnosis"
],
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[
41,
50
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0011900"
},
{
"db_name": "UMLS",
"db_id": "C0348026"
}
]
},
{
"id": "HNO.90470256.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"sleep"
],
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[
86,
91
]
],
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{
"db_name": "UMLS",
"db_id": "C0037313"
}
]
},
{
"id": "HNO.90470256.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"use"
],
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[
109,
112
]
],
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{
"db_name": "UMLS",
"db_id": "C0042153"
}
]
},
{
"id": "HNO.90470256.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"POLY-MESAM"
],
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[
176,
186
]
],
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{
"db_name": "UMLS",
"db_id": "C0036002"
}
]
},
{
"id": "HNO.90470256.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"MAP"
],
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[
194,
197
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0024779"
},
{
"db_name": "UMLS",
"db_id": "C0065864"
}
]
},
{
"id": "HNO.90470256.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"Germany"
],
"offsets": [
[
200,
207
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0017480"
}
]
}
] |
[] |
[] |
[
{
"id": "HNO.90470256.eng.abstr-s1-r1-t2.1-t4.1",
"type": "measures",
"arg1_id": "HNO.90470256.eng.abstr-s2-t2",
"arg2_id": "HNO.90470256.eng.abstr-s1-t4",
"normalized": []
},
{
"id": "HNO.90470256.eng.abstr-s1-r2-t2.2-t1.1",
"type": "occurs_in",
"arg1_id": "HNO.90470256.eng.abstr-s2-t2",
"arg2_id": "HNO.90470256.eng.abstr-s2-t1",
"normalized": []
},
{
"id": "HNO.90470256.eng.abstr-s1-r3-t1.1-t2.2",
"type": "result_of",
"arg1_id": "HNO.90470256.eng.abstr-s2-t1",
"arg2_id": "HNO.90470256.eng.abstr-s2-t2",
"normalized": []
},
{
"id": "HNO.90470256.eng.abstr-s1-r4-t2.1-t1.1",
"type": "measures",
"arg1_id": "HNO.90470256.eng.abstr-s2-t2",
"arg2_id": "HNO.90470256.eng.abstr-s2-t1",
"normalized": []
},
{
"id": "HNO.90470256.eng.abstr-s1-r5-t4.1-t2.2",
"type": "measurement_of",
"arg1_id": "HNO.90470256.eng.abstr-s1-t4",
"arg2_id": "HNO.90470256.eng.abstr-s2-t2",
"normalized": []
},
{
"id": "HNO.90470256.eng.abstr-s2-r1-t1.1-t2.2",
"type": "interacts_with",
"arg1_id": "HNO.90470256.eng.abstr-s2-t1",
"arg2_id": "HNO.90470256.eng.abstr-s2-t2",
"normalized": []
},
{
"id": "HNO.90470256.eng.abstr-s2-r2-t2.2-t1.1",
"type": "interacts_with",
"arg1_id": "HNO.90470256.eng.abstr-s2-t2",
"arg2_id": "HNO.90470256.eng.abstr-s2-t1",
"normalized": []
}
] |
HNO.90470262.eng.abstr
|
HNO.90470262.eng.abstr
|
[
{
"id": "HNO.90470262.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Peripheral facial paresis is often accompanied by incomplete closure of the eyelids and may lead to varying degrees of keratopathy . Conservative therapeutic measures are often not sufficient . To achieve better lid closure tarsorraphy has been the primary method of treatment but has certain functional and cosmetic drawbacks for the patient . Alternatively gold weight implants have been used to close the upper lid by the force of gravity and if needed can be combined with further reconstructive facial surgery . From May 1994 to January 1997 29 patients with peripheral facial paralysis were treated with gold weight upper lid implants . Postoperative closure of the lids was sufficient in all cases , and there was a statistically significant decrease in lagophthalmos and improvement in keratopathy . Complications observed included ptosis ( n=5), cosmetically unacceptable bulging of the gold implant ( n=5), extrusion of the implant ( n=1) and the development of a low-grade corneal astigmatism ( n=7). In all cases of astigmatism correction was achieved by the fitting of cylinder glasses . In all , functional results achieved showed that the gold implant was superior to the cosmetically bothersome tarsorraphy ."
],
"offsets": [
[
0,
1224
]
]
}
] |
[
{
"id": "HNO.90470262.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"paresis"
],
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[
18,
25
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0030552"
}
]
},
{
"id": "HNO.90470262.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"eyelids"
],
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[
76,
83
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0015426"
}
]
},
{
"id": "HNO.90470262.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"facial paresis"
],
"offsets": [
[
11,
25
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0427055"
}
]
},
{
"id": "HNO.90470262.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"therapeutic"
],
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[
146,
157
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0039796"
}
]
},
{
"id": "HNO.90470262.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"measures"
],
"offsets": [
[
158,
166
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0079809"
}
]
},
{
"id": "HNO.90470262.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"method"
],
"offsets": [
[
257,
263
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0025663"
},
{
"db_name": "UMLS",
"db_id": "C0025664"
}
]
},
{
"id": "HNO.90470262.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"treatment"
],
"offsets": [
[
267,
276
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0087111"
},
{
"db_name": "UMLS",
"db_id": "C0039798"
}
]
},
{
"id": "HNO.90470262.eng.abstr-s3-t3",
"type": "umlsterm",
"text": [
"cosmetic"
],
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[
308,
316
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0010164"
}
]
},
{
"id": "HNO.90470262.eng.abstr-s3-t4",
"type": "umlsterm",
"text": [
"patient"
],
"offsets": [
[
335,
342
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0030705"
}
]
},
{
"id": "HNO.90470262.eng.abstr-s4-t1",
"type": "umlsterm",
"text": [
"gold"
],
"offsets": [
[
359,
363
]
],
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{
"db_name": "UMLS",
"db_id": "C0018026"
}
]
},
{
"id": "HNO.90470262.eng.abstr-s4-t2",
"type": "umlsterm",
"text": [
"weight"
],
"offsets": [
[
364,
370
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0005910"
},
{
"db_name": "UMLS",
"db_id": "C0043100"
}
]
},
{
"id": "HNO.90470262.eng.abstr-s4-t3",
"type": "umlsterm",
"text": [
"gravity"
],
"offsets": [
[
434,
441
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0282189"
}
]
},
{
"id": "HNO.90470262.eng.abstr-s4-t4",
"type": "umlsterm",
"text": [
"surgery"
],
"offsets": [
[
507,
514
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0038894"
},
{
"db_name": "UMLS",
"db_id": "C0038895"
}
]
},
{
"id": "HNO.90470262.eng.abstr-s5-t1",
"type": "umlsterm",
"text": [
"May"
],
"offsets": [
[
522,
525
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0032335"
}
]
},
{
"id": "HNO.90470262.eng.abstr-s5-t2",
"type": "umlsterm",
"text": [
"patients"
],
"offsets": [
[
550,
558
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0030705"
}
]
},
{
"id": "HNO.90470262.eng.abstr-s5-t3",
"type": "umlsterm",
"text": [
"paralysis"
],
"offsets": [
[
582,
591
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0030440"
}
]
},
{
"id": "HNO.90470262.eng.abstr-s5-t4",
"type": "umlsterm",
"text": [
"gold"
],
"offsets": [
[
610,
614
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0018026"
}
]
},
{
"id": "HNO.90470262.eng.abstr-s5-t5",
"type": "umlsterm",
"text": [
"weight"
],
"offsets": [
[
615,
621
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0005910"
},
{
"db_name": "UMLS",
"db_id": "C0043100"
}
]
},
{
"id": "HNO.90470262.eng.abstr-s5-t6",
"type": "umlsterm",
"text": [
"facial paralysis"
],
"offsets": [
[
575,
591
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0015469"
}
]
},
{
"id": "HNO.90470262.eng.abstr-s5-t7",
"type": "umlsterm",
"text": [
"peripheral facial paralysis"
],
"offsets": [
[
564,
591
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0751142"
}
]
},
{
"id": "HNO.90470262.eng.abstr-s6-t1",
"type": "umlsterm",
"text": [
"Postoperative"
],
"offsets": [
[
643,
656
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0032790"
}
]
},
{
"id": "HNO.90470262.eng.abstr-s7-t1",
"type": "umlsterm",
"text": [
"Complications"
],
"offsets": [
[
808,
821
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0009566"
}
]
},
{
"id": "HNO.90470262.eng.abstr-s7-t2",
"type": "umlsterm",
"text": [
"ptosis"
],
"offsets": [
[
840,
846
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0005745"
},
{
"db_name": "UMLS",
"db_id": "C0033377"
}
]
},
{
"id": "HNO.90470262.eng.abstr-s7-t3",
"type": "umlsterm",
"text": [
"gold"
],
"offsets": [
[
896,
900
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0018026"
}
]
},
{
"id": "HNO.90470262.eng.abstr-s7-t4",
"type": "umlsterm",
"text": [
"development"
],
"offsets": [
[
957,
968
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0243107"
},
{
"db_name": "UMLS",
"db_id": "C0020119"
}
]
},
{
"id": "HNO.90470262.eng.abstr-s7-t5",
"type": "umlsterm",
"text": [
"astigmatism"
],
"offsets": [
[
992,
1003
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0004106"
}
]
},
{
"id": "HNO.90470262.eng.abstr-s7-t6",
"type": "umlsterm",
"text": [
"astigmatism"
],
"offsets": [
[
1028,
1039
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0004106"
}
]
},
{
"id": "HNO.90470262.eng.abstr-s7-t7",
"type": "umlsterm",
"text": [
"fitting"
],
"offsets": [
[
1071,
1078
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0036572"
}
]
},
{
"id": "HNO.90470262.eng.abstr-s7-t8",
"type": "umlsterm",
"text": [
"glasses"
],
"offsets": [
[
1091,
1098
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0017596"
},
{
"db_name": "UMLS",
"db_id": "C0015421"
}
]
},
{
"id": "HNO.90470262.eng.abstr-s8-t1",
"type": "umlsterm",
"text": [
"gold"
],
"offsets": [
[
1154,
1158
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0018026"
}
]
}
] |
[] |
[] |
[
{
"id": "HNO.90470262.eng.abstr-s2-r1-t2.1-t1.1",
"type": "conceptual_part_of",
"arg1_id": "HNO.90470262.eng.abstr-s7-t2",
"arg2_id": "HNO.90470262.eng.abstr-s8-t1",
"normalized": []
},
{
"id": "HNO.90470262.eng.abstr-s3-r1-t4.1-t2.1",
"type": "performs",
"arg1_id": "HNO.90470262.eng.abstr-s7-t4",
"arg2_id": "HNO.90470262.eng.abstr-s7-t2",
"normalized": []
},
{
"id": "HNO.90470262.eng.abstr-s3-r2-t2.1-t4.1",
"type": "affects",
"arg1_id": "HNO.90470262.eng.abstr-s7-t2",
"arg2_id": "HNO.90470262.eng.abstr-s7-t4",
"normalized": []
},
{
"id": "HNO.90470262.eng.abstr-s3-r3-t4.1-t1.1",
"type": "uses",
"arg1_id": "HNO.90470262.eng.abstr-s7-t4",
"arg2_id": "HNO.90470262.eng.abstr-s8-t1",
"normalized": []
},
{
"id": "HNO.90470262.eng.abstr-s3-r4-t2.1-t1.2",
"type": "uses",
"arg1_id": "HNO.90470262.eng.abstr-s7-t2",
"arg2_id": "HNO.90470262.eng.abstr-s3-t1",
"normalized": []
},
{
"id": "HNO.90470262.eng.abstr-s3-r5-t4.1-t1.2",
"type": "uses",
"arg1_id": "HNO.90470262.eng.abstr-s7-t4",
"arg2_id": "HNO.90470262.eng.abstr-s3-t1",
"normalized": []
},
{
"id": "HNO.90470262.eng.abstr-s3-r6-t4.1-t1.2",
"type": "performs",
"arg1_id": "HNO.90470262.eng.abstr-s7-t4",
"arg2_id": "HNO.90470262.eng.abstr-s3-t1",
"normalized": []
},
{
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] |
HNO.90470269.eng.abstr
|
HNO.90470269.eng.abstr
|
[
{
"id": "HNO.90470269.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The clinical courses of vocal rehabilitation of patients with different degrees of laryngeal paralysis can proceed very differently , but usually do not correspond with the physical changes of glottic function seen on laryngoscopy and stroboscopy . In this study 43 patients with laryngeal paralyses were examined , of whom 28 had regeneration of nerve function . Fifteen did not show any improvement in glottal function . All patients were asked to describe their voices , after which subjective data were compared to objective findings concerning vocal penetrating capacity were found to be valid in reflecting therapeutic effects and for estimating voice capability ."
],
"offsets": [
[
0,
670
]
]
}
] |
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{
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"rehabilitation"
],
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44
]
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{
"id": "HNO.90470269.eng.abstr-s1-t3",
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],
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{
"id": "HNO.90470269.eng.abstr-s1-t4",
"type": "umlsterm",
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{
"id": "HNO.90470269.eng.abstr-s1-t5",
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230
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},
{
"id": "HNO.90470269.eng.abstr-s1-t6",
"type": "umlsterm",
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"laryngeal paralysis"
],
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83,
102
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{
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},
{
"id": "HNO.90470269.eng.abstr-s2-t2",
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"text": [
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],
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290,
299
]
],
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}
]
},
{
"id": "HNO.90470269.eng.abstr-s2-t3",
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],
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331,
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}
]
},
{
"id": "HNO.90470269.eng.abstr-s2-t4",
"type": "umlsterm",
"text": [
"nerve"
],
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[
347,
352
]
],
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},
{
"id": "HNO.90470269.eng.abstr-s2-t5",
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{
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},
{
"id": "HNO.90470269.eng.abstr-s4-t3",
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465,
471
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},
{
"id": "HNO.90470269.eng.abstr-s4-t4",
"type": "umlsterm",
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{
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"id": "HNO.90470269.eng.abstr-s4-t7",
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}
] |
[] |
[] |
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HNO.90470279.eng.abstr
|
HNO.90470279.eng.abstr
|
[
{
"id": "HNO.90470279.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Facial nerve schwannomas are rare benign tumors , when occurring , they are located most frequently in the distal fallopian canal and present as extracranial masses . The predominant symptom is a progressive facial nerve paralysis . We report a 20-year-old woman with an intracranial schwannoma originating from the greater superficial petrosal nerve that had wide extension into the pterygopalatine fossa . The motor facial nerve including the geniculate ganglion was not affected . The patient presented with vertigo , progressive hearing loss and mild facial nerve synkinesis but without a lacrimation deficit . The tumor was detected by computed tomography and magnetic resonance imaging . The schwannoma was completely removed using an intracranial , extradural middle fossa approach during which complete preservation of the motor facial nerve was possible . To our knowledge this is the first reported case of an isolated schwannoma of the greater superficial petrosal nerve without involvement of the motor facial nerve ."
],
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[
0,
1029
]
]
}
] |
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}
] |
HNO.90470283.eng.abstr
|
HNO.90470283.eng.abstr
|
[
{
"id": "HNO.90470283.eng.abstr-passage-0",
"type": "abstract",
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"Deep injuries to the parotid region may result in trauma to vital structures : i . e . , the parotid gland and duct and the facial nerve and its branches . While there is no doubt concerning primary microsurgical reconstruction of injuries to the facial nerve clinical approaches for treating disruptions of the parotid duct have been controversial . A case report is presented of a secondarily reanastomosed parotid duct following complete transection . The microsurgical technique and its indications are discussed ."
],
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[
0,
518
]
]
}
] |
[
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5,
13
]
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}
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{
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}
]
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{
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93,
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{
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131,
136
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93,
106
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{
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],
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124,
136
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239
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{
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],
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254,
259
]
],
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}
]
},
{
"id": "HNO.90470283.eng.abstr-s4-t3",
"type": "umlsterm",
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"parotid"
],
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312,
319
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},
{
"id": "HNO.90470283.eng.abstr-s4-t4",
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312,
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409,
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{
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353,
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409,
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473,
482
]
],
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{
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"db_id": "C0025664"
}
]
}
] |
[] |
[] |
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},
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{
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{
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{
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{
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}
] |
HNO.90470466.eng.abstr
|
HNO.90470466.eng.abstr
|
[
{
"id": "HNO.90470466.eng.abstr-passage-0",
"type": "abstract",
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"Dendritic cells play an important role within the mucosal immune system of the upper aerodigestive tract . They process exogenous and endogenous antigens and are able to induce a cytotoxic TC/S lymphocyte reaction against tumors . Recently published data indicate that the in vitro application of tumor lysate incubated dendritic cells can provide a defense against melanoma . Before these new therapeutic strategies are available for the therapy of laryngeal cancer , basic studies have to be performed concerning the distribution of dendritic cells and other subpopulations , such as T- and B-lymphocytes and macrophages . In the present study the distribution of these subpopulations were examined within the epithelial and connective tissue compartments ( \" tumor front \" ) of 20 T2 squamous cell carcinomas of the supraglottis and glottis . The number of dendritic cells was compared with clinical parameters to check whether a high number of dendritic cells could be correlated with a better prognosis . In contrast to T-lymphocytes , results showed that dendritic cells were mainly located within the epithelial compartment of the tumors , their number ranging from 20 cells/mm2 to > 700 cells/mm2. By comparing each patient's clinical course with the number of dendritic cells , findings showed that those patients who died within the first postoperative year were characterized by a very small number of dendritic cells within their tumor tissue ( 100 cells/mm2). Although the number of patients was low , results indicate that a high number of dendritic cells within tumor tissue suggest a better prognosis ."
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[] |
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HNO.90470472.eng.abstr
|
HNO.90470472.eng.abstr
|
[
{
"id": "HNO.90470472.eng.abstr-passage-0",
"type": "abstract",
"text": [
"With the introduction of each new technique for registering eye movements , the question arises concerning whether these provide a reliable and accurate alternative for the diagnosis of labyrinthine dysfunction when compared to the most commonly used electro-oculographic technique . To answer this question we compared mean slow-phase velocity ( SPV ) using three different recording techniques : electro-oculography ( EOG ) , video-oculography ( VOG ) and infra-red oculography ( IROG ) during four different types of examinations . The examinations were the eye target tracking test ( ETT ) , horizontal and vertical optokinetic nystagmus ( OKN ) tests and the rotating chair test of the horizontal vestibulo-ocular reflex ( HVOR ) . For the ETT tests the VOG provided consistently higher mean SPV values with low variance , presumably because of the accuracy and stability of the calibration . For the horizontal OKN and VOR rotating chair tests no significant differences were found between the mean SPV obtained with the different recording techniques , although the IROG recordings were associated with a larger variance . Vertical OKN mean SPV was consistently lower with IROG and VOG techniques presumably because of non-linearities and resolution limitations inherent in these techniques . These results indicate that the EOG technique despite its disadvantages of noise , time to apply and variability of calibration still provides an inexpensive , reliable and accurate means of measuring slow-phase eye movements ."
],
"offsets": [
[
0,
1527
]
]
}
] |
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}
] |
HNO.90470479.eng.abstr
|
HNO.90470479.eng.abstr
|
[
{
"id": "HNO.90470479.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Postoperative swallowing disorders are common after such function-preserving surgery as conventional resections or endoscopic laser procedures for carcinomas of the larynx and hypopharynx . In most cases a reduction in motility of the pharyngeal muscles and sensory impairment of the pharyngeal and laryngeal regions can occur because of postoperative tissue abnormalities , including scarring due to the healing process . We have used fiberoptic endoscopic examinations with methylene blue to analyze postoperative swallowing and observe whether staining or aspiration occurs . By so doing , we have improved postoperative swallowing in 25 patients after extended surgery for cancer and were able to detect or exclude aspiration . The advantages of this minimally invasive , non-stressful diagnostic procedure are discussed and can be important for further successful care after surgery ."
],
"offsets": [
[
0,
889
]
]
}
] |
[
{
"id": "HNO.90470479.eng.abstr-s1-t1",
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"Postoperative"
],
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0,
13
]
],
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}
]
},
{
"id": "HNO.90470479.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"disorders"
],
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[
25,
34
]
],
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{
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"db_id": "C0012634"
}
]
},
{
"id": "HNO.90470479.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"surgery"
],
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[
77,
84
]
],
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},
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}
]
},
{
"id": "HNO.90470479.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"laser"
],
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126,
131
]
],
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}
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},
{
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"procedures"
],
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132,
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]
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]
},
{
"id": "HNO.90470479.eng.abstr-s1-t6",
"type": "umlsterm",
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"carcinomas"
],
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147,
157
]
],
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}
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{
"id": "HNO.90470479.eng.abstr-s1-t7",
"type": "umlsterm",
"text": [
"larynx"
],
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171
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}
]
},
{
"id": "HNO.90470479.eng.abstr-s1-t8",
"type": "umlsterm",
"text": [
"hypopharynx"
],
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176,
187
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}
]
},
{
"id": "HNO.90470479.eng.abstr-s1-t9",
"type": "umlsterm",
"text": [
"swallowing disorders"
],
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[
14,
34
]
],
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{
"db_name": "UMLS",
"db_id": "C0011168"
}
]
},
{
"id": "HNO.90470479.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"muscles"
],
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246,
253
]
],
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"db_id": "C0026845"
}
]
},
{
"id": "HNO.90470479.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"postoperative"
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338,
351
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}
]
},
{
"id": "HNO.90470479.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"tissue"
],
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352,
358
]
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}
]
},
{
"id": "HNO.90470479.eng.abstr-s2-t4",
"type": "umlsterm",
"text": [
"abnormalities"
],
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359,
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]
],
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},
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]
},
{
"id": "HNO.90470479.eng.abstr-s2-t5",
"type": "umlsterm",
"text": [
"pharyngeal muscles"
],
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235,
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},
{
"id": "HNO.90470479.eng.abstr-s3-t1",
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]
},
{
"id": "HNO.90470479.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
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],
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476,
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{
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{
"id": "HNO.90470479.eng.abstr-s3-t5",
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}
] |
[] |
[] |
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HNO.90470485.eng.abstr
|
HNO.90470485.eng.abstr
|
[
{
"id": "HNO.90470485.eng.abstr-passage-0",
"type": "abstract",
"text": [
"It is well known that alterations to the oral cavity caused by dental prostheses may affect speech articulation , although influences on the voice are not assumed . In addition to the vocal fundamental frequency , vibrations of the vocal chords generate overtones . Through the shape of the larynx and the upper airway , resonances and antiresonances are formed , and in this way overtones are amplified to a variable extent . Nozzle changes caused by a dental prosthesis in the oral cavity may possibly influence overtones but influences on the vocal fundamental frequency seem unlikely . The influence of dental prostheses on the voice is demonstrated in a patient who owned two different dental prostheses . The fundamental frequency rose by up to five semitones during speech and his vocal range increased by up to four semitones when a thin denture was used instead of a normal denture . When the position of the mandible was checked by intraoral needle point placement , a more rostral position of the mandible was recorded with the thin denture than with the normal denture . Sagittal magnetic resonance tomography imaging also showed that the larynx was in a more cranial position . This change was presumed to be due to an upward movement of the larynx induced by the tongue , which itself was found to be in a more cranial position with the thin denture . In this situation , increased tension of the laryngeal muscles were believed to induce a rise in fundamental frequency , shifting the voice range toward higher frequencies . These findings show that dental prostheses can cause vocal changes in individual cases . The etiology of this occurrence is still not clear . Its consequences , however , should be known to the dentist , ENT surgeon and phoniatrist if patients notice changes in their voice after having altered or replaced their dentures ."
],
"offsets": [
[
0,
1863
]
]
}
] |
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{
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] |
[] |
[] |
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HNO.90470490.eng.abstr
|
HNO.90470490.eng.abstr
|
[
{
"id": "HNO.90470490.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A case of nasal T-cell lymphoma as a cause of lethal midline granuloma in a 41-year-old woman is described . Primary chemotherapy as management failed , and tumor control was achieved thereafter by local radiotherapy to a dose of 52 Gy . Fourteen months after diagnosis the patient died in multiorgan failure with involvement of her skin , lung and liver . Present studies give strong evidence that lethal midline granuloma is very often a type of T-cell lymphoma that might be caused by Epstein-Barr virus . According to the literature our findings support the hypothesis that tumors are best treated by local high-dose irradiation ."
],
"offsets": [
[
0,
634
]
]
}
] |
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] |
[] |
[] |
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HNO.90470494.eng.abstr
|
HNO.90470494.eng.abstr
|
[
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"The megadolichobasilar artery is a rare vascular anomaly that can cause a variety of clinical symptoms but is usually asymptomatic . Not much attention has been given as yet to a possible sensorineural hearing loss caused by a megadolichobasilar anomaly . Vascular compression of the vestibulocochlear nerve must be assumed to be the pathogenic factor . The megadolichobasilar anomaly represents a rare entity in the differential diagnosis of sudden idiopathic sensorineural hearing loss . More common causes are acoustic neuromas , monosymptomatic Menière's disease and rupture of the round window membrane . We present the case of a 71-year-old white male in whom magnetic resonance angiography combined with contrast-enhanced computed tomography in three-dimensional reconstruction eventually led to the diagnosis of megadolichobasilar anomaly . The combination of both imaging techniques may be required for the effective diagnosis of similar vascular anomalies ."
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[] |
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] |
HNO.90470535.eng.abstr
|
HNO.90470535.eng.abstr
|
[
{
"id": "HNO.90470535.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The study presents an analysis of 20 cases of acute acoustic trauma caused by toy pistols . The problem generally involves boys within the age range from 6 to 11 years . Half of the incidents involved attacks with toy pistols used as weapons . Auditory damage appeared in two types , each of which had a notch in the audiogram at the frequency range between 10 and 14 kHz . In children , a shot close to one ear can damage both ears . Great differences in the severity of tinnitus were apparent . The most severe cases of tinnitus were observed in the children with no or minor premanent auditory damage . Children experiencing long periods of uninterrupted tinnitus suffer significantly . This is not only detrimental to family-life but also to the performance of the children at school . The total expenses of treatment for these 20 cases were estimated to be approximately 80,000 DM ( 40.000 Euro ) ."
],
"offsets": [
[
0,
903
]
]
}
] |
[
{
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],
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22,
30
]
],
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}
]
},
{
"id": "HNO.90470535.eng.abstr-s1-t2",
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"acoustic"
],
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[
52,
60
]
],
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"db_id": "C0001166"
}
]
},
{
"id": "HNO.90470535.eng.abstr-s1-t3",
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"text": [
"trauma"
],
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}
] |
[] |
[] |
[
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"normalized": []
}
] |
HNO.90470541.eng.abstr
|
HNO.90470541.eng.abstr
|
[
{
"id": "HNO.90470541.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Background : Currently normal or pathologic conditions are documental by color slides , photos or videotape . However , it is more difficult to manage large numbers of images and to recall specific pictures or videos at any time . Digital record achives may be a solution for this problem ."
],
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0,
290
]
]
}
] |
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] |
[] |
[] |
[] |
HNO.90470546.eng.abstr
|
HNO.90470546.eng.abstr
|
[
{
"id": "HNO.90470546.eng.abstr-passage-0",
"type": "abstract",
"text": [
"To achieve septoplasty without compromising the surgical goal of attaining a straight and solid septum , even in cases of marked deviations or severe post-traumatic deformities , we now use a new technique in which the septal reconstruction includes the placement of a resorbable implant as a \" compound graft \" . For this purpose the entire septal cartilage is removed , and the severely deviated part is divided into straight sections that are reconnected to each other to form a straight and solid plate . As connecting material we use a polydioxanon ( PDS ) foil . The sections of cartilage are sutured to the foil with PDS suture material . The compound graft thus constructed consists of the septal cartilage and resorbable alloplastic material and is reimplanted into the nose . The PDS and suture material are usually resorbed within 8 months , excluding long-term complications . During the past 2 years this method was used in treating 38 patients . The surgical goal was attained in every case , and no immediate or long-term complications occurred . This method of combining septal cartilage with a resorbable implant leads to a better , significant correction of even severe septal deviations ."
],
"offsets": [
[
0,
1207
]
]
}
] |
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{
"id": "HNO.90470546.eng.abstr-s1-t3",
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{
"id": "HNO.90470546.eng.abstr-s7-t2",
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"id": "HNO.90470546.eng.abstr-s8-t1",
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{
"id": "HNO.90470546.eng.abstr-s8-t2",
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{
"id": "HNO.90470546.eng.abstr-s8-t3",
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]
},
{
"id": "HNO.90470546.eng.abstr-s9-t2",
"type": "umlsterm",
"text": [
"cartilage"
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"normalized": [
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"db_id": "C0007301"
}
]
}
] |
[] |
[] |
[
{
"id": "HNO.90470546.eng.abstr-s1-r1-t4.1-t3.1",
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HNO.90470556.eng.abstr
|
HNO.90470556.eng.abstr
|
[
{
"id": "HNO.90470556.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Sex change surgery for patients with gender identity disorders has been performed successfully during the last decade , especially for males becoming females . A troublesome problem for some of these individuals is the retention of a male voice . Castration and estrogen therapy may produce only minor changes in pitch , with patients requiring further surgical treatment . Techniques used include glottoplasty , crico thyroid approximation and/or anterior commissure advancement . Although the voice is highly gender-specific , the standards of care for transsexuals do not cover guidelines for a diagnostic approach and surgical therapy . For medical jurisprudence , questions concerning specific aspects of German social law are answered in a representative case of a male-to-female transsexual . A review of the literature shows that there is no common thought about whether and when a specific surgical procedure should be performed in a gender-transforming process and which method should be used for long-term results and patient satisfaction . Although world-wide experience with these operations and overall good results are assumed , further reports by phonosurgeons performing these operations are required concerning actual results . We propose that medical scientific societies should offer phonosurgery as an optional treatment for male-to-female transsexuals in their guidelines and standards of care ."
],
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[] |
[] |
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] |
HNO.90470563.eng.abstr
|
HNO.90470563.eng.abstr
|
[
{
"id": "HNO.90470563.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Hemangiomas of the skull base are rare neoplasms and are easily misdiagnosed as acoustic neuromas when occurring in the internal auditory canal . Among these tumors , ossifying hemangiomas are characterized histologically be newly formed bone tissue within their substance . We describe a 26-year old female patient who presented with left-sided sensorineural hearing loss and tinnitus . T2-weighted magnetic resonance imaging demonstrated a bright space-occupying lesion of the internal auditory canal with extension to the geniculate ganglion . Bony erosions of the internal auditory canal were proved by high-resolution computed tomography . A hemangioma was suspected preoperatively and was resected via a middle cranial fossa approach . Histologically , new bone formations were found in a cavernous hemangioma . In general , radiologic findings can suggest a hemangioma of the internal auditory canal and help to differentiate it from acoustic neuroma . Based on the histological findings of intratumoral bone formation , the hemangioma in our patient was classified as an ossifying hemangioma . However , reactive bone formation at the borders of a tumor in the internal auditory canal can also be mistaken as new intratumoral bone formation ."
],
"offsets": [
[
0,
1250
]
]
}
] |
[
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],
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0,
11
]
],
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}
]
},
{
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],
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19,
24
]
],
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{
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],
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39,
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]
],
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{
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80,
88
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},
{
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89,
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},
{
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},
{
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],
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80,
97
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],
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]
},
{
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],
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129,
143
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],
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}
]
},
{
"id": "HNO.90470563.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"tumors"
],
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[
158,
164
]
],
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{
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}
]
},
{
"id": "HNO.90470563.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"hemangiomas"
],
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[
177,
188
]
],
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] |
[] |
[] |
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HNO.90470569.eng.abstr
|
HNO.90470569.eng.abstr
|
[
{
"id": "HNO.90470569.eng.abstr-passage-0",
"type": "abstract",
"text": [
"There are many reasons for cervical lymph-node enlargement . In particular , the large group of infectious diseases must be considered along with malignant diseases . The coexistence of an uncommon infectious disease with malignant disease is a rare event . We report the case of an otherwise healthy 69-year-old man with marked enlargement of his cervical lymph nodes . A diagnosis of a recent toxoplasmosis infection was made based on positive IgG and IgM toxoplasma titers and the results of fine-needle aspiration from a lymph node . Since the enlarged lymph nodes persisted for more than weeks , the lymph node was excised . Histological examination revealed a non-Hodgkin's lymphoma . IgM titers in toxoplasmosis can persist up to 1 year . In cases with rare infectious diseases like toxoplasmosis in immunocompromized patients , swollen lymph nodes that persist or grow should lead to the suspicion of additional disease . A diagnosis can be confirmed by removing a lymph node for histology ."
],
"offsets": [
[
0,
999
]
]
}
] |
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{
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] |
[] |
[] |
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] |
HNO.90470573.eng.abstr
|
HNO.90470573.eng.abstr
|
[
{
"id": "HNO.90470573.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Extracranial meningiomas of the head and neck region are very rare , although secondary extracranial meningiomas beside meningiomas of primary extracranial origin have also been described . Trauma , radiation and ( uncommonly ) metastatic spread have been associated with the pathogenesis of secondary extracranial meningiomas . We present a case of a 53-year-old patient who required six neurosurgical interventions because of a recurrent intracranial meningioma . Further surgery was required for tumor in the left parotid gland . Histological examination of this neoplasm showed an atypical meningotheliomatous meningioma . The patient is now 17 months after surgery and is free of local recurrences or metastases ."
],
"offsets": [
[
0,
718
]
]
}
] |
[
{
"id": "HNO.90470573.eng.abstr-s1-t1",
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"meningiomas"
],
"offsets": [
[
13,
24
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0025286"
}
]
},
{
"id": "HNO.90470573.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"head"
],
"offsets": [
[
32,
36
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0018670"
}
]
},
{
"id": "HNO.90470573.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"neck"
],
"offsets": [
[
41,
45
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[] |
[] |
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HNO.90470602.eng.abstr
|
HNO.90470602.eng.abstr
|
[
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"id": "HNO.90470602.eng.abstr-passage-0",
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"text": [
"Background : Specific immunotherapy ( SIT ) of allergic disorders as introduced by Freeman and Noon involves the application of gradually increasing doses of extracts of the material to which the individual is sensitive . SIT represents the only specific treatment that can be offered to allergic patients besides allergen avoidance . SIT has been widely used in patients with pollen allergic rhinitis and its clinical efficacy has been demonstrated in several controlled clinical trials . The underlying mechanism of this treatment is still not understood . Previous studies have focused on changes in serum antibodies , including blunting of seasonal rises in specific IgE and increases in specific IgG antibodies , especially of the IgG4 isotype . Recent studies have suggested an effect on T-lymphocytes , leading to a switch from a predominant Th2 response - that is , interleukin ( IL ) -4 and IL-5 - to a Th1 response involving interferon ( IFN ) - . The switch of a cytokine profile to a predominant IFN- response results in inhibition of IL-4 dependent IgE production , which is reinforced by a decrease in the production of IL-4 by Th2 cells ."
],
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}
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] |
[] |
[] |
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}
] |
HNO.90470623.eng.abstr
|
HNO.90470623.eng.abstr
|
[
{
"id": "HNO.90470623.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Reconstructive plastic surgery is not always possible or advisable for nasal defects following tumor resections . Facial prostheses offer an alternative therapy . Since 1991 , 37 patients with nasal defects after tumor surgery were treated in the Berlin Center of Facial Prostheses : 28 received \" soft \" silicone facial prostheses and 9 \" solid \" polymethylmetacrylate facial prostheses . In 35 patients protheses were bone-anchored : Brånemark implants were used in 12 patients and an Epitec frame construction in 23 patients . Glue-on prostheses were applied to only two patients . No intraoperative complications occurred at implant insertion . During following visits only minor inflammations were observed around implants and were treated locally . The implant success rate was 78% for the Brånemark implants ( 89.7% in non- radiated areas and 50% in radiated areas ) and 100% in radiated and non-radiated areas for the Epitec system . Our investigation shows that given the right indication , the bone-anchored facial prosthesis is safe , cosmetically acceptable , uncomplicated and not stressful for the patient ."
],
"offsets": [
[
0,
1121
]
]
}
] |
[
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],
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22
]
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{
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"surgery"
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}
]
},
{
"id": "HNO.90470623.eng.abstr-s1-t3",
"type": "umlsterm",
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"defects"
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{
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]
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},
{
"id": "HNO.90470623.eng.abstr-s1-t5",
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"plastic surgery"
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15,
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]
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]
},
{
"id": "HNO.90470623.eng.abstr-s2-t1",
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]
},
{
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]
},
{
"id": "HNO.90470623.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
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] |
[] |
[] |
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HNO.90470629.eng.abstr
|
HNO.90470629.eng.abstr
|
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[] |
[] |
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},
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"id": "HNO.90470629.eng.abstr-s1-r21-t1.1-t9.1",
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] |
HNO.90470637.eng.abstr
|
HNO.90470637.eng.abstr
|
[
{
"id": "HNO.90470637.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Sjoegren's syndrome is an important auto-immune disease in the head and neck . Patients have an increased arrival risk of up to 6% per year for developing B-cell lymphomas , including mucosa-associated lymphoid tissue ( MALT ) lymphomas . The following case report shows this relation and the difficulty of differentiating clinically recurrent swelling of the parotid gland in Sjoegren's syndrome from malignant lymphoma . A 64-year-old woman had a 2-year history of indolent , recurrent swelling of both parotid glands . Blood examination showed elevated ESR and a hypergammaglobulinemia . Immunosupressive therapy produced no improvement . Two years after the diagnosis of Sjoegren's syndrome , swelling of the left parotid gland persisted . Superficial parotidectomy of the left side was performed and histopathological examination revealed a MALT-related lymphoma . Subsequent parotidectomy of the right side also showed infiltration of the gland by a MALT lymphoma . Postoperative radiation therapy was given . During the follow-up period no recurrence or systemic disease was detected . Patients with Sjoegren's syndrome should be examined regularly by the otolaryngologist . If a lymphoma cannot be ruled out , open biopsy must be considered for histological diagnosis . Prognostic factors for developing a lymphoma are possibly a high ESR and hypergammaglobulinemia . Further prognostic factors have to be evaluated ."
],
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[
0,
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]
]
}
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] |
[] |
[] |
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}
] |
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