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Cell-Type-Specific Decrease of the Intrinsic Excitability of Motor Cortical Pyramidal Neurons in Parkinsonism
|
neuroscience
|
The E3 ligase TRIM1 ubiquitinates LRRK2 and controls its localization, degradation, and toxicity
|
molecular biology
|
Evolution of diversity in metabolic strategies
|
evolutionary biology
|
Mutational meltdown of microbial altruists in Streptomyces coelicolor colonies
|
evolutionary biology
|
Viral susceptibility across host species is largely independent of dietary protein to carbohydrate ratios
|
evolutionary biology
|
The wheat 55K SNP-based exploration of loci for spikelet number per spike from a tetraploid wheat (Triticum turgidum L.) recombinant inbred line population derived from a Chinese landrace Ailanmai and a wild emmer accession
|
genetics
|
Inhibitory interneurons show early dysfunction in a SOD1 mouse model of ALS
|
neuroscience
|
Explainable Machine Learning Approach to Predict and Explain the Relationship between Task-based fMRI and Individual Differences in Cognition
|
neuroscience
|
Compensatory hepatic adaptation accompanies permanent absence of intrahepatic biliary network due to YAP1 loss in liver progenitors
|
pathology
|
Context dependent activation and repression of enhancers by Hunchback binding sites in Drosophila embryo
|
developmental biology
|
PharmaNet: Pharmaceutical discovery with deep recurrent neural networks.
|
bioinformatics
|
A deep learning algorithm for 3D cell detection in whole mouse brain image datasets
|
neuroscience
|
Genetic effects on brain traits impact cell-type specific gene regulation during neurogenesis
|
genetics
|
Executive function supports single-shot endowment of value to arbitrary transient goals
|
neuroscience
|
Forty years of change in a monomictic tropical lake
|
ecology
|
Plant Scaffolds Support Motor Recovery and Regeneration in Rats after Traumatic Spinal Cord Injury
|
bioengineering
|
Distinct Phenotypes of SARS-CoV-2 Isolates Reveal Viral Traits Critical for Replication in Primary Human Respiratory Cells
|
microbiology
|
Automated Feature Extraction from Large Cardiac Electrophysiological Data Sets
|
physiology
|
Absence of postsynaptic activity on developing neurons alters gene expression profiles without preventing the refinement of inputs
|
neuroscience
|
Histone H2A ubiquitination resulting from Brap loss of function connects multiple aging hallmarks and accelerates neurodegeneration
|
neuroscience
|
Circular RNAs exhibit limited evidence for translation, or translation regulation of the mRNA-counterpart in terminal hematopoiesis
|
molecular biology
|
Evaluation of pigmentation gene knock-outs by CRISPR as potential targets for the genetic engineering of Culex quinquefasciatus
|
genetics
|
A computationally tractable birth-death model that combines phylogenetic and epidemiological data
|
genomics
|
Polyploidy-associated paramutation in Arabidopsis is determined by small RNAs, temperature, and allele structure
|
genetics
|
Mapping the organization and dynamics of the posterior medial network during movie watching
|
neuroscience
|
PEPATAC: An optimized pipeline for ATAC-seq data analysis with serial alignments
|
genomics
|
Cuttlefish: Fast, parallel, and low-memory compaction of de Bruijn graphs from large-scale genome collections
|
bioinformatics
|
A 9-kDa matricellular SPARC fragment released by cathepsin D exhibits pro-tumor activity in the triple-negative breast cancer microenvironment
|
cancer biology
|
Lymphatic PD-L1 expression restricts tumor-specific CD8+ T cell responses
|
immunology
|
A Gut Microbial Peptide and Molecular Mimicry in the Pathogenesis of Type 1 Diabetes
|
immunology
|
Thermally tolerant symbionts may explain Caribbean octocoral resilience to heat stress
|
evolutionary biology
|
Asymmetric directed functional connectivity within the frontoparietal motor network during motor imagery and execution
|
neuroscience
|
PSK signaling controls ABA homeostasis and signaling genes and maintains shoot growth under osmotic stress
|
plant biology
|
In vitro gut modeling as a tool for adaptive evolutionary engineering of Lactiplantibacillus plantarum
|
evolutionary biology
|
Atlas of tissue-specific and tissue-preferential gene expression in ecologically and economically significant conifer Pinus sylvestris
|
genomics
|
Quantifying growth perturbations over the fattening period in swine via mathematical modelling
|
systems biology
|
A new method to accurately identify single nucleotide variants using small FFPE breast samples.
|
genomics
|
Multivariate genome-wide association study identifies 780 unique genetic loci associated with cortical morphology.
|
genetics
|
Cell group analysis reveals changes in upper-layer neurons associated with schizophrenia
|
genomics
|
mRNA based SARS-CoV-2 vaccine candidate CVnCoV induces high levels of virus neutralizing antibodies and mediates protection in rodents
|
immunology
|
Potential Achilles heels of SARS-CoV-2 are best displayed by the base order-dependent component of RNA folding energy
|
microbiology
|
ATRX alteration contributes to tumor growth and immune escape in pleomorphic sarcomas
|
cancer biology
|
A damaged informed lung ventilator model for ventilator waveforms
|
physiology
|
The Oscillatory Effects of Rhythmic Median Nerve Stimulation
|
neuroscience
|
A unified physiological framework of transitions between seizures, sustained ictal activity, and depolarization block at the single neuron level
|
neuroscience
|
Environmental enrichment enhances patterning and remodeling of synaptic nanoarchitecture revealed by STED nanoscopy
|
neuroscience
|
Limited and strain-specific transcriptional and growth responses to acquisition of a multidrug resistance plasmid in genetically diverse Escherichia coli lineages
|
microbiology
|
Structural classification of proteins based on the computationally efficient recurrence quantification analysis and horizontal visibility graphs
|
bioinformatics
|
In vivo visualization of propagating α-synuclein pathologies in mouse and marmoset models by a bimodal imaging probe, C05-05
|
neuroscience
|
Dynamics of sex chromosome evolution in a rapid radiation of cichlid fishes
|
evolutionary biology
|
Functional Molecular Switches of Mammalian G Protein-Coupled Bitter-Taste Receptors
|
bioinformatics
|
homologizer: Phylogenetic phasing of gene copies into polyploid subgenomes
|
evolutionary biology
|
Differences in the gut microbiomes of distinct ethnicities within the same geographic area are linked to host metabolic health
|
microbiology
|
Viral mimicry of p65/RelA transactivation domain to inhibit NF-κB activation
|
microbiology
|
SRF-MYOCD axis is the targetable driver of a well differentiated aggressive subtype of leiomyosarcomas
|
cancer biology
|
Neural Mechanism of Hunger Gated Food-seeking and evaluating
|
neuroscience
|
CSF-1 maintains pathogenic but not homeostatic myeloid cells in the central nervous system during autoimmune neuroinflammation.
|
immunology
|
Speciation in the face of gene flow within the toothed whale superfamily Delphinoidea
|
evolutionary biology
|
A computational approach to evaluate the combined effect of SARS-CoV-2 RBD mutations and ACE2 receptor genetic variants on infectivity: The COVID-19 host-pathogen nexus
|
molecular biology
|
Cortical Responses to the Amplitude Envelopes of Sounds Change with Age
|
neuroscience
|
Time scale separation of information processing between sensory and associative regions
|
neuroscience
|
Attribution of Cancer Origins to Endogenous, Exogenous, and Actionable Mutational Processes
|
cancer biology
|
Geometric and Topological Approaches to Shape Variation in Ginkgo Leaves
|
plant biology
|
Coordination of gene expression noise with cell size: analytical results for agent-based models of growing cell populations
|
systems biology
|
Parasitic success and venom composition evolve upon specialization of parasitoid wasps to different host species
|
evolutionary biology
|
Machine-learning predicts genomic determinants of meiosis-driven structural variation in a eukaryotic pathogen
|
genomics
|
Fitting quantum machine learning potentials to experimental free energy data: Predicting tautomer ratios in solution
|
biophysics
|
A tunable population timer in multicellular consortia
|
synthetic biology
|
Assumptions about frequency-dependent architectures of complex traits bias measures of functional enrichment
|
genetics
|
Life history tradeoffs, division of labor and evolutionary transitions in individuality
|
evolutionary biology
|
A Fast Data-Driven Method for Genotype Imputation, Phasing, and Local Ancestry Inference: MendelImpute.jl
|
genetics
|
Neural networks to learn protein sequence-function relationships from deep mutational scanning data
|
bioinformatics
|
Alleloscope: Integrative single cell analysis of allele-specific copy number alterations and chromatin accessibility in cancer
|
bioinformatics
|
Connectome Gradient Dysfunction in Major Depression and Its Association with Gene Expression Profiles
|
neuroscience
|
Diffusion-Informed Spatial Smoothing of fMRI Data in White Matter Using Spectral Graph Filters
|
neuroscience
|
Decoding subjective emotional arousal from EEG during an immersive Virtual Reality experience
|
neuroscience
|
Transcriptional Diversity of Medium Spiny Neurons in the Primate Striatum
|
neuroscience
|
Heavily burned wood from wildfires is less likely to provide functionality in streams
|
ecology
|
CaMKII binds both substrates and activators at the active site
|
biochemistry
|
Structural basis of rotavirus RNA chaperone displacement and RNA annealing
|
biophysics
|
Multimodal profiling of lung granulomas reveals cellular correlates of tuberculosis control
|
immunology
|
Deep-learning based identification, pose estimation and end-to-end behavior classification for interacting primates and mice in complex environments
|
neuroscience
|
Biotransformation of lindane (γ-hexachlorocyclohexane) to non-toxic end products by sequential treatment with three mixed anaerobic microbial cultures
|
microbiology
|
The Genetics and Evolution of Eye Color in Domestic Pigeons (Columba livia)
|
genetics
|
Mosaic Evolution of Cognitive Skills in Mammals
|
animal behavior and cognition
|
A validated generally applicable approach using the systematic assessment of disease modules by GWAS reveals a multi-omic module strongly associated with risk factors in multiple sclerosis
|
bioinformatics
|
A novel DNA-binding protein regulates sexual differentiation in malaria parasites and is essential for transmission.
|
microbiology
|
Characterization and structural prediction of the putative ORF10 protein in SARS-CoV-2
|
microbiology
|
Ancestral circuits for vertebrate colour vision emerge at the first retinal synapse
|
neuroscience
|
LINE-1 retrotransposons facilitate horizontal gene transfer into poxviruses
|
microbiology
|
Nitric Oxide Regulates the Ralstonia solanacearum Type 3 Secretion System
|
microbiology
|
Principal component analysis of RNA-seq data unveils a novel prostate cancer-associated gene expression signature
|
cancer biology
|
Post-exposure protection of SARS-CoV-2 lethal infected K18-hACE2 transgenic mice by neutralizing human monoclonal antibody
|
immunology
|
Evolutionary dynamics of neutral phenotypes under DNA substitution models
|
evolutionary biology
|
No impact of functional connectivity of the motor system on the resting motor threshold: A replication study.
|
neuroscience
|
HybPhaser: a workflow for the detection and phasing of hybrids in target capture datasets
|
evolutionary biology
|
TGS1 controls snRNA 3' end processing, prevents neurodegeneration and ameliorates SMN-dependent neurological phenotypes in vivo
|
genetics
|
Insights into long non-coding RNA regulation of anthocyanin carrot root pigmentation
|
genomics
|
Pseudomonas aeruginosa PA14 produces R-bodies, extendable protein polymers with roles in host colonization and virulence
|
microbiology
|
Hidden genetic variation in plasticity increases the potential to adapt to novel environments
|
evolutionary biology
|
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