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Repurposing of mitochondria-targeted tamoxifen: Novel anti-cancer drug exhibits potent activity against major protozoan and fungal pathogens.
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microbiology
|
Transcriptome-wide Analyses of Adipose Tissue in Outbred Rats Reveal Genetic Regulatory Mechanisms Relevant for Human Obesity
|
genomics
|
Improved And Optimized Drug Repurposing For The SARS-CoV-2 Pandemic
|
bioinformatics
|
LSMMD-MA: Scaling multimodal data integration for single-cell genomics data analysis
|
bioinformatics
|
A cell cycle-linked mechanism for the glutamine driven establishment of stem cell fate
|
cell biology
|
Unmyelinated neurons use Neuregulin signals to promote myelination of neighboring neurons in the CNS
|
developmental biology
|
Autoantibody discovery across monogenic, acquired, and COVID19-associated autoimmunity with scalable PhIP-Seq
|
immunology
|
Recognition of copy-back defective interfering rabies virus genomes by RIG-I triggers the antiviral response against vaccine strains
|
microbiology
|
The lectin LecB induces patches with basolateral characteristics at the apical membrane to promote Pseudomonas aeruginosa host cell invasion
|
microbiology
|
Discovery of a Novel Inhibitor for Chikungunya Virus
|
microbiology
|
First description of a Yersinia pseudotuberculosis clonal outbreak in France, confirmed using a new core genome multilocus sequence typing method
|
microbiology
|
Why is the average collateral effect of synonymous mutations so similar across alternative reading frames?
|
evolutionary biology
|
Using genome scans to identify genes used repeatedly for adaptation
|
evolutionary biology
|
Global, regional, and cryptic population structure in a high gene-flow transatlantic fish
|
evolutionary biology
|
Gamete interaction protein evolution evinces Pantherines hybridizing history
|
evolutionary biology
|
Full-length transcriptome maps of reef-building coral illuminate the molecular basis of calcification, symbiosis, and circadian genes
|
evolutionary biology
|
High resolution analysis of proteolytic substrate processing
|
biochemistry
|
B cell receptor repertoire analysis unveils dynamic antibody response and severity markers in COVID-19 patients
|
immunology
|
SARS-CoV-2 harnesses host translational shutoff and autophagy to optimize virus yields: The role of the envelope (E) protein
|
microbiology
|
A Computational Pipeline to Identify Potential Drug Targets and Interacting Chemotypes in SARS-CoV-2
|
bioinformatics
|
Acute manipulation and real-time visualization of membrane trafficking and exocytosis in Drosophila
|
cell biology
|
Patient-derived parathyroid organoids as tracer and drug-screening application model
|
cell biology
|
A nuclear receptor facilitates differentiation of human PSCs into more mature hepatocytes
|
developmental biology
|
Forest refuge areas and carbon emissions from tropical deforestation in the 21st century
|
ecology
|
Fewer non-native insects in freshwater than in terrestrial habitats across continents
|
ecology
|
flashfm-ivis: interactive visualisation for fine-mapping of multiple quantitative traits
|
genetics
|
High-throughput and high-sensitivity biomarker monitoring in body fluid by FAIMS-enhanced fast LC SureQuant™ IS targeted quantitation
|
biochemistry
|
Transfer learning of an in vivo-derived senescence signature identifies conserved and tissue-specific senescence across species and diverse pathologies
|
bioengineering
|
MRSCloud: a Cloud-based MR Spectroscopy Tool for Basis Set Simulation
|
bioengineering
|
Inference of B cell clonal families using heavy/light chain pairing information
|
bioinformatics
|
Ontology-Aware Biomedical Relation Extraction
|
bioinformatics
|
Crimp: fast and scalable cluster relabeling based on impurity minimization
|
bioinformatics
|
Competitive membrane wetting of polymer blends in artificial cells initiates phase separation and promotes fractionation
|
biophysics
|
Long-term cellular cargo tracking reveals intricate trafficking through active cytoskeletal networks
|
biophysics
|
Cellular Mechanisms Underlying Central Sensitization in a Mouse Model of Chronic Muscle Pain
|
neuroscience
|
Production of a functionally active recombinant SARS-CoV-2 (COVID-19) 3C-Like protease and a soluble inactive 3C-like protease-RBD chimeric in a prokaryotic expression system
|
biochemistry
|
Changes of urinary proteomic before and after QIV and COVID-19 vaccination
|
biochemistry
|
Comparative Analysis of Right Ventricular Metabolic Reprogramming in Pre-clinical Rat Models of Severe Pulmonary Hypertension-induced Right Ventricular Failure
|
physiology
|
A Novel Restraint Device to Improve Safety and Efficacy of Blood Collection During Non-Terminal Sampling of Bats
|
zoology
|
Prenatal methadone exposure leads to long-term memory impairments and disruptions of dentate granule cell function in a sex-dependent manner
|
neuroscience
|
Neural activity in the anterior cingulate cortex is required for effort-based decision making
|
neuroscience
|
Elucidating the role of c-di-AMP in Mycobacterium smegmatis: phenotypic characterization and functional analysis
|
microbiology
|
Human neutrophils direct epithelial cell extrusion to enhance intestinal epithelial host defense during Salmonella infection
|
microbiology
|
Towards a multi-stressor theory for coral reefs in a changing world
|
ecology
|
Sex and genetic specific effects on behavioral, but not metabolic, responses to a high fat diet in heterogeneous stock rats
|
genetics
|
Intrathecal tracer dispersion is accelerated by high volume injection and natural micromixing
|
bioengineering
|
Reproducible acquisition, management, and meta-analysis of nucleotide sequence (meta)data using q2-fondue
|
bioinformatics
|
A model for quorum-sensing mediated stochastic biofilm nucleation
|
biophysics
|
Structure-based Evolution of G protein-biased μ-opioid Receptor Agonists
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pharmacology and toxicology
|
An in-silico analysis of experimental designs to study right ventricular function and pulmonary hypertension
|
physiology
|
The gender gap in academic career achievements and the mediation effect of work-family conflict and partner support
|
scientific communication and education
|
Particle-Swarm Based Modelling Reveals Two Distinct Classes of CRHPVN Neurons
|
neuroscience
|
Increased fatty acid metabolism and decreased glycolysis are hallmarks of metabolic reprogramming in the brain during recovery from experimental stroke
|
neuroscience
|
Two mosquito odorant receptors with reciprocal specificity mediated by a single amino acid residue
|
neuroscience
|
Multiple-timescale dynamics, mixed mode oscillations and mixed affective states in a model of Bipolar Disorder
|
neuroscience
|
Quadripulse Stimulation: A Replication Study with A Newly Developed Stimulator
|
neuroscience
|
Structure and influence in an interconnected world: neurocomputational mechanism of real-time distributed learning on social networks
|
neuroscience
|
FKS1 is required for Cryptococcus neoformans fitness in vivo: application of copper-regulated gene expression to mouse models of cryptococcosis
|
microbiology
|
The effects of antibiotic combination treatments on Pseudomonas aeruginosa tolerance evolution and coexistence with Stenotrophomonas maltophilia
|
microbiology
|
The genomics and physiology of abiotic stressors associated with global elevation gradients in Arabidopsis thaliana
|
evolutionary biology
|
Conserved patterns across ion channels correlate with variant pathogenicity and clinical phenotypes
|
genetics
|
An integrative analysis of the biological clock hypothesis in human gut microbiome
|
bioinformatics
|
Seqrutinator: Non-Functional Homologue Sequence Scrutiny for the Generation of large Datatsets for Protein Superfamily Analysis
|
bioinformatics
|
The traits of skull anatomy in green frogs of the genus Pelophylax (Anura, Ranidae)
|
zoology
|
The Rise and Fall of Slow Wave Tides: Vacillations of Slow Wave/Spindle Coupling Shift the Composition of Slow Wave Activity Through Sleep Cycles in Accordance with Depth of Sleep
|
neuroscience
|
Microglial Piezo1 senses Aβ fibrils stiffness to restrict Alzheimer's disease
|
neuroscience
|
Connexin36 expression in the cochlear nucleus complex of the echolocating bat, Eptesicus fuscus
|
neuroscience
|
Marked regional glial heterogeneity in the human white matter of the central nervous system
|
neuroscience
|
CD4 binding-site antibodies induced by a subtype B HIV-1 envelope trimer
|
immunology
|
Effects of mucin and DNA concentrations in airway mucus on Pseudomonas aeruginosa biofilm recalcitrance
|
microbiology
|
Efficient rescue of a newly classified Ebinur lake orthobunyavirus with GFP reporter and its application in rapid antiviral screening
|
molecular biology
|
Large-scale analysis and computer modeling reveal hidden regularities behind variability of cell division patterns in Arabidopsis thaliana embryogenesis
|
developmental biology
|
Dynamics in vertical transmission of viruses in naturally selected and traditionally managed honey bee colonies across Europe
|
ecology
|
Population dynamics of free-roaming dogs in Europe and implications for population control
|
ecology
|
Prevalence Estimates of Putatively Pathogenic Leptin Variants in the gnomAD Database
|
genetics
|
Genetics of Fertility Restoration in A1 Cytoplasmic Genetic Male Sterility (CGMS) Systems in Sorghum (Sorghum bicolor L. Moench)
|
genetics
|
Influence of residual microbial nucleic acid in instruments for hip joint arthroplasty on false-positive results of metagenomic sequencing
|
genomics
|
The DNA-based global positioning system--a theoretical framework for large-scale spatial genomics
|
bioinformatics
|
Large-bodied ornithomimosaurs inhabited Appalachia during the Late Cretaceous of North America
|
paleontology
|
Evidence for the role of music on the growth and signal response in duckweed
|
plant biology
|
Differential Hebbian learning with time-continuous signals for active noise reduction
|
neuroscience
|
Cardio PyMEA: A user-friendly, open-source Python application for cardiomyocyte microelectrode array analysis
|
cell biology
|
The Graphical R2D2 Estimator for the Precision Matrices
|
bioinformatics
|
Examination of genome-wide ortholog variation in clinical and environmental isolates of the fungal pathogen Aspergillus fumigatus
|
bioinformatics
|
NAb-seq: an accurate, rapid and cost-effective method for antibody long-read sequencing in hybridoma cell lines and single B cells
|
bioinformatics
|
Rad51 is a druggable target that sustains replication fork progression upon DNA replication stress
|
cell biology
|
Neural responses to biological motion distinguish autistic and schizotypal traits in the general population
|
neuroscience
|
Individual behavioral trajectories shape whole-brain connectivity in mice
|
neuroscience
|
Successor-like representation guides the prediction of future events in human visual cortex and hippocampus
|
neuroscience
|
Neural Correlates of Linguistic Collocations During Continuous Speech Perception
|
neuroscience
|
At-home blood collection and stabilization in high temperature climates using homeRNA
|
bioengineering
|
Multifactorial remodeling of the cancer immunopeptidome by interferon gamma
|
cancer biology
|
Keratose sponges in ancient carbonates - a problem of interpretation
|
paleontology
|
Hypomorphism of a novel long ERα isoform causes severe reproductive dysfunctions in female mice
|
physiology
|
A new monoclonal antibody enables BAR analysis of subcellular importin β1 interactomes
|
neuroscience
|
RNA-targeting CRISPR-Cas13 Provides Broad-spectrum Phage Immunity
|
microbiology
|
Conserved GYXLI motif of FlhA is involved in dynamic domain motions of FlhA required for flagellar protein export
|
microbiology
|
Candida albicans filamentation does not require the cAMP-PKA pathway in vivo
|
microbiology
|
Transcriptome of epibiont Saccharibacteria Nanosynbacter lyticus strain TM7x during establishment of symbiosis
|
microbiology
|
Comparative Genome Analysis of Lactobacillus acidophilus Isolates from Different Ecological Niches
|
microbiology
|
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