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Structure-guided synthesis of FK506 and FK520 analogs with increased selectivity exhibit in vivo therapeutic efficacy against C. neoformans
|
microbiology
|
Drug design and repurposing with a sequence-to-drug paradigm
|
molecular biology
|
A Conformation-specific Nanobody Targeting the NMN-activated State of SARM1
|
molecular biology
|
Telomerase-independent maintenance of telomere length in a vertebrate
|
molecular biology
|
Chemical inhibition of prolyl hydroxylases impairs angiogenic competence of human vascular endothelium through metabolic reprogramming
|
molecular biology
|
Structural basis of transcription antitermination by Q{lambda}: NusA induces refolding of Q{lambda} to form nozzle for RNA polymerase exit channel
|
molecular biology
|
Reciprocity and interaction effectiveness in generalised mutualisms among free-living species
|
ecology
|
Unearthing the global impact of mining construction minerals on biodiversity
|
ecology
|
On-farm Implementation of Midseason Drainage to Decrease Greenhouse Gas Emissions and Grain Arsenic Concentration in Rice Systems
|
ecology
|
HIV-1 CD4-binding site germline antibody-Env structures inform vaccine design
|
biochemistry
|
Structural visualization of the tubulin folding pathway directed by eukaryotic chaperonin TRiC
|
biochemistry
|
Sub-cellular dynamic investigation of the multi-component drug on the gastric cancer cell BGC823 using Raman spectroscopy
|
bioengineering
|
Glioblastoma states are defined by cohabitating cellular populations with progression-, imaging- and sex-distinct patterns
|
cancer biology
|
The effect of Septoria glycines and fungicide application on the soybean phyllosphere mycobiome
|
plant biology
|
Differentiation of airway cholinergic neurons from human pluripotent stem cells for airway neurobiology studies
|
neuroscience
|
EPHierStats: a statistical tool to model the hierarchical relationships in electrophysiological data
|
neuroscience
|
GASEOUS TRANSMITTER MODULATION OF HYPOGLOSSAL MOTONEURON ACTIVITY
|
neuroscience
|
Coregistration of heading to visual cues in retrosplenial cortex
|
neuroscience
|
Microbial Energy Metabolism Fuels a CSF2-dependent Intestinal Macrophage Niche within Tertiary Lymphoid Organs
|
immunology
|
Genomic diversity across Candida auris clinical isolates shapes rapid development of antifungal resistance in vitro and in vivo
|
microbiology
|
Genetic glyco-profiling and rewiring of insulated flagellin glycosylation pathways
|
microbiology
|
Distribution and genomic variation of thermophilic cyanobacteria in diverse microbial mats at the upper temperature limits of photosynthesis
|
microbiology
|
Infection dynamics of co-transmitted reproductive symbionts are mediated by sex, tissue, and development
|
microbiology
|
Epigenetic modulators link mitochondrial redox homeostasis to cardiac function
|
molecular biology
|
Korean endemic species no more: on the occurrence of Pelophylax chosenicus in China
|
ecology
|
Polytypy and systematics: diversification of Papilio swallowtail butterflies in the biogeographically complex Indo-Australian Region
|
evolutionary biology
|
Spatiotemporal variations in retrovirus-host interactions among Darwin's finches
|
evolutionary biology
|
Intestinal epithelial Axin1 deficiency protects against colitis via altered gut microbiota
|
pathology
|
Cyb5r3-based mechanism and reversal of secondary failure to sulfonylurea
|
physiology
|
Thiazides induce glucose intolerance through inhibition of mitochondrial carbonic anhydrase 5b in β-cells
|
physiology
|
Unleashing the Potential of Noncanonical Amino Acid Biosynthesis for Creation of Cells with Site-Specific Tyrosine Sulfation
|
synthetic biology
|
In silico Investigation of Molecular Networks Linking Gastrointestinal Diseases, Malnutrition, and Sarcopenia
|
systems biology
|
SCAMPR: Single-Cell Automated Multiplex Pipeline for RNA Quantification and Spatial Mapping
|
neuroscience
|
Fast-synaptic axo-axonal transmission from striatal cholinergic interneurons onto dopamine fibers.
|
neuroscience
|
Nr2f1-dependent shaping of mitochondrial architecture in newborn mouse hippocampal neurons unravels novel insights into the neurodevelopmental disorder BBSOAS
|
neuroscience
|
mTORC2 coordinates the leading and trailing edge cytoskeletal programs during neutrophil migration
|
cell biology
|
Degeneracy in the neurological model of auditory speech repetition
|
neuroscience
|
Inter-brain coupling reflects disciplinary differences in real-world classroom learning
|
neuroscience
|
Indirect decoding of behavior from brain signals via reconstruction of experimental conditions
|
neuroscience
|
Gata2-regulated Gfi1b expression controls endothelial programming during endothelial-to-hematopoietic transition
|
developmental biology
|
Modeling phytoplankton-zooplankton interactions: opportunities for species richness and challenges for modern coexistence theory
|
ecology
|
Environmental response in gene expression and DNA methylation reveals factors influencing the adaptive potential of Arabidopsis lyrata
|
evolutionary biology
|
The maintenance of self-incompatibility: overdominance of inbreeding depression and S-linked genetic load
|
evolutionary biology
|
Study of aging using circuit tests and parametric analysis
|
animal behavior and cognition
|
Designing Cost-Effective, Open-Source, Multi-Head Bioprinters via Conversion of Hobby-Grade 3D Printers
|
bioengineering
|
Extended longevity geometrically-inverted proximal tubule organoids for protein uptake studies
|
bioengineering
|
Gfastats: conversion, evaluation and manipulation of genome sequences using assembly graphs
|
bioinformatics
|
bpRNA-align: Improved RNA Secondary Structure Global Alignment for Comparing and Clustering RNA Structures
|
bioinformatics
|
CellSium - Versatile Cell Simulator for Microcolony Ground Truth Generation
|
bioinformatics
|
diemr: Genome polarisation for detecting barriers to geneflow in R
|
bioinformatics
|
StrainXpress: strain aware metagenome assembly from short reads
|
bioinformatics
|
L-GIREMI uncovers RNA editing sites in long-read RNA-seq
|
bioinformatics
|
Proton-transporting heliorhodopsins from marine giant viruses
|
biophysics
|
TCGADEPMAP -- Mapping Translational Dependencies and Synthetic Lethalities within The Cancer Genome Atlas
|
cancer biology
|
Multi-omic analysis of the cardiac cellulome defines a vascular contribution to cardiac diastolic dysfunction in obese female mice
|
physiology
|
Spatiotemporal patterns of sleep spindle activity in human anterior thalamus and cortex
|
neuroscience
|
Two modes of mid-frontal theta suggest a role in conflict and error processing
|
neuroscience
|
Stable working memory and perceptual representations in macaque lateral prefrontal cortex during naturalistic vision in virtual environments
|
neuroscience
|
Local 5-HT signal bi-directionally regulates the coincidence time window of associative learning
|
neuroscience
|
HALO: A software tool for real-time head alignment in the MR scanner
|
neuroscience
|
Temporal dynamics of cognitive flexibility in adolescents with anorexia nervosa: a high density EEG study
|
neuroscience
|
Structural and functional MRI data differentially predict chronological age and behavioral memory performance
|
neuroscience
|
Suboptimal foraging decisions and involvement of the ventral tegmental area in human opioid addiction
|
neuroscience
|
A novel maxillofacial technique to deliver drugs to the visual pathway, the optic nerve and the retina using the glymphatic system.
|
neuroscience
|
Peripheral blood T-cell deficiency and hyperinflammatory monocyte responses associate with MAC lung disease
|
immunology
|
Longitudinal single cell transcriptional and epigenetic mapping of effector, memory, and exhausted CD8 T cells reveals shared biological circuits across distinct cell fates
|
immunology
|
Spatial exploration of immune cell heterogeneity in skin functional scar-less wound regeneration model at single-cell resolution
|
immunology
|
AIRRscape: an interactive tool for exploring B-cell receptor repertoires and antibody responses
|
immunology
|
PIP4K2B is a mechanosensor and induces heterochromatin-driven nuclear softening through UHRF1.
|
cell biology
|
The role of hepatitis B virus surface protein in inducing Sertoli cell ferroptosis
|
cell biology
|
DiSiR: a software framework to identify ligand-receptor interactions at subunit level from single-cell RNA-sequencing data
|
cell biology
|
Germline/soma distinction in Drosophila embryos requires regulators of zygotic genome activation
|
developmental biology
|
Scalable Generation of Pseudo-Unipolar Sensory Neurons from Human Pluripotent Stem Cells
|
developmental biology
|
Combinatorial interactions of Hox genes establish appendage diversity of the amphipod crustacean Parhyale hawaiensis
|
developmental biology
|
Zinc as a non-hormonal contraceptive: a better alternative to the copper intrauterine device (IUD)
|
developmental biology
|
Ecological diversity exceeds evolutionary diversity in model ecosystems
|
ecology
|
Long-term temperature trend in Kamchatka supports expansion of harmful algae
|
ecology
|
Mark loss can strongly bias demographic rates in multi-state models: a case study with simulated and empirical datasets
|
ecology
|
Habitat resource overlap in two broad-ranged sympatric Neotropical forest eagles
|
ecology
|
sdmTMB: an R package for fast, flexible, and user-friendly generalized linear mixed effects models with spatial and spatiotemporal random fields
|
ecology
|
Sexual selection on female copulatory devices in an insect with nuptial gifts
|
evolutionary biology
|
Facultative parthenogenesis in an asexual stick insect: re-evolution of sex or vestigial sexual capacity?
|
evolutionary biology
|
Ecological and evolutionary consequences of selective interspecific information use
|
evolutionary biology
|
A spatial genome aligner for multiplexed DNA-FISH
|
genomics
|
circRAB3IP modulates cell proliferation by reorganizing gene expression and mRNA processing in a paracrine manner
|
genomics
|
A chromosome-level assembly of the "Cascade" hop (Humulus lupulus) genome provides insights into Cannabaceae evolution
|
genomics
|
A global high-density chromatin interaction network reveals functional long-range and trans-chromosomal relationships
|
genomics
|
Discordant genotype calls across technology platforms elucidate variants with systematic errors in next-generation sequencing
|
genomics
|
Bursts of genomic instability potentiate phenotypic and genomic diversification in Saccharomyces cerevisiae
|
genomics
|
Stress-induced transcriptional readthrough into neighboring genes is linked to intron retention
|
genomics
|
Dynamic interaction of bacterial cellulose synthase subunit D (BcsD) in type I bacterial cellulose synthase
|
biochemistry
|
Modulation of RNA binding properties of the RNA helicase UPF1 by its activator UPF2
|
biochemistry
|
Treatment with an Antigen-Specific Dual Microparticle System Reverses Advanced Multiple Sclerosis in Mice
|
bioengineering
|
Variants identify sarcomere inter-protein contacts distinguishing inheritable cardiac muscle diseases
|
bioinformatics
|
Repositioning linifanib as a potent anti-necroptosis agent for sepsis
|
bioinformatics
|
PLO3S : Protein LOcal Surficial Similarity Screening
|
bioinformatics
|
Extraction and analysis of methylation features from Pacific Biosciences SMRT reads using MeStudio
|
bioinformatics
|
Effective holistic characterization of small molecule effects using heterogeneous biological networks
|
bioinformatics
|
SIEVE: joint inference of single-nucleotide variants and cell phylogeny from single-cell DNA sequencing data
|
bioinformatics
|
PPML-Omics: a Privacy-Preserving federated Machine Learning system protects patients' privacy from omic data
|
bioinformatics
|
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