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Structural dynamics of Zika Virus NS1 via a reductionist approach reveal the disordered nature of its beta roll domain in isolation
|
biophysics
|
Protein kinase D promotes prostate cancer cell bone metastasis by positively regulating Runx2 in a MEK/ERK1/2-dependent manner
|
cancer biology
|
Plant-on-Chip: core morphogenesis processes in the tiny plant Wolffia australiana
|
plant biology
|
Dual orexin antagonist DORA-22 suppressed posttraumatic seizures and enhances GABAergic inhibition in dentate granule cells
|
neuroscience
|
Asymmetric activation of microglia in the hippocampus drives anxiodepressive consequences of trigeminal neuralgia
|
neuroscience
|
mGlu2 and mGlu3 receptor negative allosteric modulators affect the discriminative stimulus effects of alcohol
|
neuroscience
|
Peptidergic signaling controls the dynamics of sickness behavior in Caenorhabditis elegans
|
neuroscience
|
CD200R1 promotes IL-17 production by ILC3s, by enhancing STAT3 activation
|
immunology
|
Characterization of enterovirus D68 infection in four nonhuman primate species
|
microbiology
|
Gene editing is suitable to treat GM1 Gangliosidosis: a proof-of-concept study
|
genetics
|
Development of a high-density 665 K SNP array for rainbow trout genome-wide genotyping
|
genomics
|
An atlas of genetic scores to predict multi-omic traits
|
genomics
|
Calculating ATP production rates from oxidative phosphorylation and glycolysis during cell activation
|
biochemistry
|
Subchondral bone and synovial fluid metabolomic profiles are altered in injured and contralateral limbs 7 days after non-invasive joint injury in skeletally-mature C57BL/6 mice
|
bioengineering
|
Inferring functions of coding and non-coding genes using epigenomic patterns and deciphering the effect of combinatorics of transcription factors binding at promoters
|
bioinformatics
|
HiCHub: A Network-Based Approach to Identify Domains of Differential Interactions from 3D Genome Data
|
bioinformatics
|
SOAR: a spatial transcriptomics analysis resource to model spatial variability and cell type interactions
|
bioinformatics
|
MetaPhage: an automated pipeline for analyzing, annotating, and classifying bacteriophages in metagenomics sequencing data.
|
bioinformatics
|
The bacterial lectin LecA from P. aeruginosa alters membrane organization by dispersing ordered domains
|
biophysics
|
Newly discovered alleles of the tomato antiflorigen gene SELF PRUNING provide a range of plant compactness and yield
|
plant biology
|
Uncovering the "ZIP code" for bZIP dimers reveals novel motifs, regulatory rules and one billion years of cis-element evolution
|
molecular biology
|
A cobB like protein in Oryza sativa indica regulates the mitochondrial machinery under stress conditions
|
plant biology
|
HOPX governs a molecular and physiological switch between cardiomyocyte progenitor and maturation gene programs
|
developmental biology
|
Mycn regulates intestinal development through ribosomal biogenesis in a zebrafish model of Feingold syndrome 1
|
developmental biology
|
In vitro and in vivo antioxidant therapeutic evaluation of Dodonaea viscosa Jacq.
|
plant biology
|
Public exams provide opportunities for deeper thought with less anxiety
|
scientific communication and education
|
Application and Evaluation of Flipped Teaching Based on Video Conference in Standardized Training for Internal Medicine Residents during Vacation
|
scientific communication and education
|
Insulated expression of periplasmic uricase in E. coli Nissle 1917 for the treatment of hyperuricemia
|
synthetic biology
|
Chlamydia trachomatis effector Dre1 interacts with dynactin to reposition host organelles during infection
|
microbiology
|
The Effects of Vitamin E Analogues α-Tocopherol and γ-Tocotrienol on the Human Osteocyte Response to Ultra-high Molecular Weight Polyethylene Wear Particles
|
cell biology
|
Evolution of self-sustained circadian rhythms requires seasonal change of daylight
|
evolutionary biology
|
Diversity chromosome evolution of Ty1-copia Retrotransposons in Pennisetum purpureum Revealed by FISH
|
genetics
|
Multi-marker DNA metabarcoding detects suites of environmental gradients from an urban harbour
|
genomics
|
WFA-GPU: Gap-affine pairwise alignment using GPUs
|
bioinformatics
|
The field of protein function prediction as viewed by different domain scientists
|
bioinformatics
|
TITAN: A Toolbox for Information-Theoretic Analysis of Molecular Networks
|
bioinformatics
|
US-align: Universal Structure Alignments of Proteins, Nucleic Acids, and Macromolecular Complexes
|
bioinformatics
|
A deep reinforcement learning approach to reconstructing quaternary structures of protein dimers through self-learning
|
bioinformatics
|
scTour: a deep learning architecture for robust inference and accurate prediction of cellular dynamics
|
bioinformatics
|
Metastatic potential in clonal melanoma cells is driven by a rare, early-invading subpopulation
|
cancer biology
|
Immunological Synapse Dynamics Induced by Bispecific T-cell Engagers Predict Clinical Pharmacodynamics and Tumor Evolution across Anatomical Sites
|
pharmacology and toxicology
|
A systems biology approach to disentangle the direct and indirect effects of global transcription factors on gene expression in Escherichia coli
|
systems biology
|
Organelle-selective click labeling coupled with flow cytometry allows high-throughput CRISPR screening of genes involved in phosphatidylcholine metabolism
|
cell biology
|
Green Lacewing Chrysoperla rufilabris (Neuroptera: Chrysopidae) is a potential biological agent for controlling crapemyrtle bark scale (Hemiptera: Eriococcidae)
|
ecology
|
Comparative analysis of temperature preference behavior and effects of temperature on daily behavior in eleven Drosophila species
|
evolutionary biology
|
Highly parallelized laboratory evolution of wine yeasts for enhanced metabolic phenotypes
|
bioengineering
|
gr Predictor: a Deep-Learning Model for Predicting the Hydration Structures around Proteins
|
biophysics
|
Roles of Clamp Closing and Allosteric Effects of Discriminator and Upstream Interactions on Downstream Elements in Stabilizing an E. coli RNA Polymerase-Promoter Open Complex
|
biophysics
|
Benchmarking the Widely Used Structure-based Binding Affinity Predictors on the Spike-ACE2 Deep Mutational Interaction Set
|
bioinformatics
|
In Silico transcriptional analysis of asymptomatic and severe COVID-19 patients reveals the susceptibility of severe patients to other comorbidities and non-viral pathological conditions
|
bioinformatics
|
Persistent post-COVID-19 smell loss is associated with inflammatory infiltration and altered olfactory epithelial gene expression
|
neuroscience
|
The SARS-CoV-2 Omicron BA.1 spike G446S potentiates HLA-A*24:02-restricted T cell immunity
|
immunology
|
Ocular tropism of SARS-CoV-2 with retinal inflammation through neuronal invasion in animal models
|
microbiology
|
Antibody escape and cryptic cross-domain stabilization in the SARS CoV-2 Omicron spike protein
|
immunology
|
Reassessing the helix bundle crossing model for gating in a non-selective ion channel
|
biochemistry
|
A chip-based array for high-resolution fluorescence characterization of free-standing horizontal lipid membranes under voltage clamp
|
bioengineering
|
Coisolation of peptide pairs for peptide identification and MS/MS-based quantification
|
systems biology
|
Localization, induction, and cellular effects of tau-phospho-threonine 217
|
neuroscience
|
Fleeting Effects of Incentives: Adult Age Differences in ERP Measures of Motivated Attention
|
neuroscience
|
Neural instructive signals for associative cerebellar learning
|
neuroscience
|
Pyochelin biotransformation shapes bacterial competition
|
microbiology
|
The DNA replication initiation protein DnaD is recruited to a specific strand of the Bacillus subtilis chromosome origin
|
molecular biology
|
SirA inhibits the essential DnaA:DnaD interaction to block helicase recruitment during Bacillus subtilis sporulation
|
molecular biology
|
Lithium-induced ciliary lengthening sparks Arp2/3 complex-dependent endocytosis
|
cell biology
|
Extracellular matrix assembly stress drives Drosophila central nervous system morphogenesis
|
developmental biology
|
Genome-wide detection of human variants that disrupt intronic branchpoints
|
genetics
|
Homing pigeon (Columba livia) dominance hierarchies are stable over time and resistant to perturbation
|
animal behavior and cognition
|
Sequence dependencies and biophysical features both govern cleavage of diverse cut-sites by HIV protease
|
biochemistry
|
Flexible control of representational dynamics in a disinhibition-based model of decision making
|
neuroscience
|
HNRNPH1 destabilizes the G-quadruplex structures formed by G-rich RNA sequences that regulate the alternative splicing of an oncogenic fusion transcript
|
molecular biology
|
Trophoblast and blood vessel organoid cultures recapitulate the role of WNT2B in promoting intravillous vascularization in human intrauterine and ectopic pregnancy
|
cell biology
|
Severe drought events trigger long-term salt marsh dieback in the Southeastern and Gulf of Mexico USA
|
ecology
|
Transcriptional dynamics of transposable elements in the type I IFN response in Myotis lucifugus cells
|
evolutionary biology
|
genomeSidekick: a user-friendly epigenomics data analysis tool
|
genomics
|
Transcriptome-guided annotation and functional classification of long non-coding RNAs in Arabidopsis thaliana
|
genomics
|
Phertilizer: growing a clonal tree from ultra-low coverage single-cell DNA sequencing data of tumors
|
bioinformatics
|
MetaRelSubNetVis: Referenceable network visualizations based on integrated patient data with group-wise comparison
|
bioinformatics
|
Sirtuin gene isoforms and genomic sequences of mouse and humans: Divergence across species
|
genetics
|
A coupled atrioventricular-aortic setup for in-vitro hemodynamic study of the systemic circulation: Design, Fabrication, and Physiological relevancy
|
bioengineering
|
GeneticsMakie.jl: A versatile and scalable toolkit for visualizing locus-level genetic and genomic data
|
bioinformatics
|
Modeling COVID-19 disease biology to identify drug treatment candidates
|
systems biology
|
Quantitative modeling demonstrates format-invariant representations of mathematical problems in the brain
|
neuroscience
|
Synaptotagmin 9 modulates spontaneous neurotransmitter release in striatal neurons by regulating substance P secretion
|
neuroscience
|
Sequence characterization of the complete chloroplast genome of Eupatorium fortunei
|
bioinformatics
|
NuRD independent Mi-2 activity represses ectopic gene expression during neuronal maturation.
|
developmental biology
|
Bleaching-resistant single-molecule fluorescence and FRET monitoring based on fluorophore exchange via transient DNA binding
|
biophysics
|
Biofilms preserve transmissibility of a multi-drug resistance plasmid
|
microbiology
|
Route of oxytetracycline administration differentially impacts the growth and gut microbiome of pigs co-infected with Bordetella bronchiseptica and Pasteurella multocida
|
microbiology
|
The yeast claudin Dcv1 is important for demarcating the front domain of pheromone-responding yeast cells
|
cell biology
|
Sperm-mediated regulation of region-specific responses in the oviduct during establishment of pregnancy in mice
|
cell biology
|
A multi-continental analysis of the responses of freshwater food webs to climate and land use change
|
ecology
|
Men in menopause? Experimental verification of the mate choice theory of menopause with Drosophila melanogaster
|
evolutionary biology
|
A flexible modeling and inference framework for estimating variant effect sizes from GWAS summary statistics
|
genomics
|
Ultrafast and interpretable single-cell 3D genome analysis with Fast-Higashi
|
bioinformatics
|
Stress fibers orient traction forces on micropatterns: A hybrid cellular Potts model study
|
biophysics
|
Examining the efficacy of localised gemcitabine therapy for the treatment of pancreatic cancer using a hybrid agent-based model
|
cancer biology
|
High-dimensional and spatial analysis reveals immune landscape dependent progression in cutaneous squamous cell carcinoma
|
pathology
|
The role of environmental calcium in the extreme acid tolerance of northern banjo frog (Limnodynastes terraereginae) larvae
|
physiology
|
A Chitin-Binding Protein Ultra-highly expressed in the Outer Fold of Mantle is Related to Shell Colour in Pacific Oyster Crassostrea gigas
|
physiology
|
Structure-guided investigations into HMG-CoA reductase as a herbicide target
|
plant biology
|
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