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Pre-T cell receptor Self-MHC Sampling Restricts Thymocyte Dedifferentiation
|
immunology
|
Plasma membrane topography governs the three-dimensional dynamic localization of IgM B cell receptor clusters
|
cell biology
|
California's forest carbon offsets buffer pool is severely undercapitalized
|
ecology
|
Developmental changes of opsin gene expression in ray-finned fishes (Actinopterygii)
|
evolutionary biology
|
Complete sequences of six Major Histocompatibility Complex haplotypes, including all the major MHC class II structures
|
genomics
|
A Novel Y-Shaped, S-O-N-O-S-Bridged Crosslink between Three Residues C22, C44, and K61 Is a Redox Switch of the SARS-CoV-2 Main Protease
|
biochemistry
|
Systematic analysis of alternative splicing in time course data using Spycone
|
bioinformatics
|
Differentiated dynamic response in C. elegans chemosensory cilia
|
biophysics
|
Smoke exposed roots causes reduced whole-plant vascular sectoriality.
|
physiology
|
Age-related changes in neural synchronization and the sustained response to amplitude and frequency modulation of sound
|
neuroscience
|
A model of the mouse cortex with attractor dynamics explains the structure and emergence of rsfMRI co-activation patterns
|
neuroscience
|
Microglial ferroptotic stress causes non-cell autonomous neuronal death
|
neuroscience
|
Sex Differences in Central Amygdala Reactivity following Psychedelic Drug Exposure
|
neuroscience
|
A bacteriophage-based, highly efficacious, needle and adjuvant-free, mucosal COVID-19 vaccine
|
microbiology
|
Touch receptor end-organ innervation and function requires sensory expression of the transcription factor Meis2.
|
developmental biology
|
Long-term temporal trends in gastrointestinal parasite infection in wild Soay sheep
|
ecology
|
A Unifying Statistical Framework to Discover Disease Genes from GWAS
|
genomics
|
Argon plasma-modified bacterial cellulose filters for protection against respiratory pathogens
|
bioengineering
|
Benchmark of tools for in silico prediction of MHC class I and class II genotypes from NGS data
|
bioinformatics
|
Data-driven Identification of Total RNA Expression Genes (TREGs) for Estimation of RNA Abundance in Heterogeneous Cell Types
|
bioinformatics
|
Mechanism of multimodal substrate translocation in P-glycoprotein
|
biophysics
|
Genome-wide screen for enhanced noncanonical amino acid incorporation in yeast
|
synthetic biology
|
C-Jun N-terminal Kinase Promotes Stress Granule Assembly and Neurodegeneration in C9orf72-mediated ALS and FTD
|
neuroscience
|
Classification of electrically-evoked compound action potentials in the parkinsonian subthalamic nucleus of non-human primates
|
neuroscience
|
Polyphyly of the Niphargus stygius species group (Crustacea, Amphipoda, Niphargidae) in the Southern Limestone Alps
|
evolutionary biology
|
Modeling Transient Brain Coactivity Patterns in Latent Space with FMRI Data
|
bioengineering
|
TAMPA: interpretable analysis and visualization of metagenomics-based taxon abundance profiles
|
bioinformatics
|
Detergent headgroups control TolC folding in vitro
|
biophysics
|
Senescence-Induced Immune Remodeling Facilitates Metastatic Adrenal Cancer in a Sex-Dimorphic Manner
|
cancer biology
|
Lysosomal alterations and decreased electrophysiological activity in CLN3 disease (966 bp deletion, E295K) patient-derived cortical neurons
|
neuroscience
|
Immediate myeloid depot for SARS-CoV-2 in the human lung
|
immunology
|
Regenerating axolotl retinas regrow diverse cell types with modulation by Notch signaling and reconnect to the brain
|
neuroscience
|
Bacterial catabolic system of acetovanillone and acetosyringone useful for upgrading aromatic compounds obtained through chemical lignin depolymerization
|
microbiology
|
High fat diet changes bacterial signatures in the murine pancreas
|
microbiology
|
Molecular Determinants of Tissue Specificity of Flavivirus Nonstructural Protein 1 Interaction with Endothelial Cells
|
microbiology
|
'Erythritol, a safe natural sweetener exhibits multi-stage anti-malarial activity by blocking Plasmodium falciparum membrane transporter 'aquaporin
|
molecular biology
|
Cortical tracking of lexical speech units in a multi-talker background is immature in school-aged children
|
neuroscience
|
HIV-1 Rev-RRE Functional Activity in Primary Isolates is Highly Dependent on Minimal Context-Dependent Changes in Rev
|
microbiology
|
Few amino acid mutations in H6 influenza A virus from South American lineage increase pathogenicity in poultry
|
microbiology
|
Core genome sequencing and genotyping of Leptospira interrogans in clinical samples by target capture sequencing
|
microbiology
|
CpG enrichment as a vaccine strategy for influenza A virus
|
microbiology
|
Divergent transcriptional response to thermal stress among life stages could constrain coral adaptation to climate change
|
molecular biology
|
Neryl acetate, the major component of Corsican Helichrysum Italicum essential oil, mediates its biological activities on skin barrier
|
molecular biology
|
Signals Generated by Neutrophil Receptors for Danger Molecules Transactivate Allosterically Modulated FFA2R: Distinct response patterns are mediated by modulators recognized by different allosteric receptor sites
|
cell biology
|
Loss of heterochromatin at endogenous retroviruses creates competition for transcription factor binding
|
genomics
|
Multiscale obstruction sensitivity in collective cell migration
|
biophysics
|
Model building in SHELXE
|
biophysics
|
A quorum sensing-regulated type VI secretion system containing multiple nonredundant VgrG proteins is required for interbacterial competition in Chromobacterium violaceum
|
microbiology
|
Extensive uORF translation from HIV-1 transcripts conditions DDX3 dependency for expression of main ORFs and elicits specific T cell immune responses in infected individuals
|
microbiology
|
You will know by its tail: a method for quantification of heterogeneity of bacterial populations using single cell MIC profiling
|
microbiology
|
In situ structure of a dimeric hibernating ribosome from a eukaryotic intracellular pathogen
|
molecular biology
|
Novel CRISPR-based detection of Leishmania species
|
molecular biology
|
Actin cytoskeleton signaling via MRTF/SRF entrains circadian clock
|
cell biology
|
Elevated CD47 is a hallmark of dysfunctional aged muscle stem cells that can be targeted to augment regeneration
|
cell biology
|
Off-target integron activity leads to rapid plasmid compensatory evolution in response to antibiotic selection pressure
|
evolutionary biology
|
New insights from short and long reads sequencing to explore cytochrome b variants of Plasmopara viticola populations collected in vineyard and related to resistance to complex III inhibitors
|
evolutionary biology
|
Selenocyanate Derived Se-Incorporation into the Nitrogenase Fe Protein Cluster
|
biochemistry
|
Nanobodies identify an activated state of the TRIB2 pseudokinase
|
biochemistry
|
Cells function as a ternary logic gate to decide migration direction under integrated chemical and fluidic cues
|
biophysics
|
Robustness of the autophagy pathway to somatic copy number losses
|
cancer biology
|
The contribution of Neanderthal introgression and natural selection to neurodegenerative diseases
|
neuroscience
|
Nipsnap1- A Regulatory Factor Required for Long-Term Maintenance of Non-Shivering Thermogenesis
|
molecular biology
|
Histone deacetylase 6 inhibition promotes microtubule acetylation and facilitates autophagosome-lysosome fusion in dystrophin-deficient mdx mice
|
cell biology
|
Aβ42 and Aβ40 oligomers form transient and persistent pores with different time evolutions and toxicities
|
cell biology
|
Transcription factor binding sites are frequently under accelerated evolution in primates
|
evolutionary biology
|
Comparison of R9.4.1/Kit10 and R10/Kit12 Oxford Nanopore flowcells and chemistries in bacterial genome reconstruction
|
genomics
|
H4K16ac activates transcription of transposable elements and contribute to their cis regulatory function
|
genomics
|
DeepSlice: rapid fully automatic registration of mouse brain imaging to a volumetric atlas
|
neuroscience
|
The Features Underlying the Memorability of Objects
|
neuroscience
|
Ablation of palladin in adult heart causes dilated cardiomyopathy associated with intercalated disc abnormalities
|
molecular biology
|
Intracellular injection of brain extracts from Alzheimer's disease patients trigger unregulated Ca2+ release from intracellular stores that hinders cellular bioenergetics
|
cell biology
|
An improved pipeline for reprogramming human induced pluripotent stem cells with TET1
|
cell biology
|
SPTLC1 variants associated with childhood onset amyotrophic lateral sclerosis produce distinct sphingolipid signatures through impaired interaction with ORMDL proteins
|
biochemistry
|
Hyperimmune bovine colostrum containing lipopolysaccharide antibodies (Imm124-E) has a non-detrimental effect on gut microbial communities in unchallenged mice.
|
microbiology
|
MEIG1/PACRG associated and non-associated functions of axonemal dynein light intermediate polypeptide 1 (DNALI1) in mammalian spermatogenesis
|
cell biology
|
Actin-regulated Siglec-1 nanoclustering influences HIV-1 capture and virus-containing compartment formation in dendritic cells
|
cell biology
|
Thyroid hormone and ALK5 inhibitor improve maturation of human pluripotent stem cell derived hepatocytes
|
developmental biology
|
Divergence of trafficking and polarity mechanisms for PIN auxin transporters during land plant evolution
|
evolutionary biology
|
Machine learning-based detection of label-free cancer stem-like cell fate
|
bioinformatics
|
The replication stress response suppresses mutation rates in mismatch repair deficient budding yeast and human cancers
|
cancer biology
|
Rewiring of liver diurnal transcriptome rhythms by triiodothyronine (T3) supplementation
|
physiology
|
PILS proteins provide a homeostatic feedback on auxin signaling output
|
plant biology
|
GB_SynP: a modular dCas9-regulated synthetic promoter collection for fine-tuned recombinant gene expression in plants.
|
synthetic biology
|
The activation of mGluR4 rescues parallel fiber LTP, motor learning and social behavior in a mouse model of Fragile X Syndrome
|
neuroscience
|
5' Untranslated mRNA Regions Allow Bypass of Host Cell Translation Inhibition by Legionella pneumophila
|
microbiology
|
Long Term Virucidal Activity of Rosin Soap on Surfaces
|
microbiology
|
Partial refuges from biological control due to intraspecific variation in protective host traits: a case study with the egg parasitoid Trissolcus japonicus
|
ecology
|
Sorting Single T cells based on Secreted Cytokines and Surface Markers using Hydrogel Nanovials
|
bioengineering
|
Genomic analyses identify significant biological processes in DDX21-mediated colorectal cancer cells
|
bioinformatics
|
Early steps of embryo implantation are regulated by exchange of extracellular vesicles between the embryo and the endometrium
|
physiology
|
BMAL1 loss in oligodendroglial lineage cells dysregulates myelination and sleep
|
neuroscience
|
Evidence for the presence and diagnostic utility of SPM in human peripheral blood
|
immunology
|
A guide for membrane potential measurements in Gram-negative bacteria using voltage-sensitive dyes
|
microbiology
|
Characterization of the DNA binding domain of StbA, a key protein of a new type of DNA segregation system
|
microbiology
|
Dispersal between interconnected patches can reduce the total population size
|
ecology
|
Adaptation of the eyes of grass puffer (Takifugu niphobles) to the riverine and marine environments
|
evolutionary biology
|
The mutational landscape of single neurons and oligodendrocytes reveals evidence of inflammation-associated DNA damage in multiple sclerosis
|
genomics
|
A chromosome-length genome assembly and annotation of blackberry (Rubus argutus, cv. Hillquist)
|
genomics
|
Inferring sources of suboptimality in perceptual decision making using a causal inference task
|
animal behavior and cognition
|
Protein complex prediction using Rosetta, AlphaFold, and mass spectrometry covalent labeling
|
biophysics
|
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