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MEK inhibitor resistance in lung cancer cells associated with addiction to sustained ERK suppression
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cancer biology
|
Effects of lowered o and membrane depolarization on the Ca2+ transients of fast skeletal muscle fibers. Implications for muscle fatigue.
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physiology
|
NSF/αSNAP2-mediated cis-SNARE complex disassembly precedes membrane fusion generating the cell plate during Arabidopsis cytokinesis
|
plant biology
|
Chemical ecology of Himalayan eggplant variety's antixenosis: Identification of geraniol as an oviposition deterrent against the eggplant shoot and fruit borer
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plant biology
|
Local field potentials and single unit dynamics in motor cortex of unconstrained macaques during different behavioral states
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neuroscience
|
EndophilinA-dependent coupling between activity-dependent calcium influx and synaptic autophagy is disrupted by a Parkinson-risk mutation
|
neuroscience
|
Effects of calcium-regulated autophagy on Candidatus Liberibacter solanacearum in carrot psyllid midguts
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molecular biology
|
MCIBox: A Toolkit for Single-molecule Multi-way Chromatin Interaction Visualization and Micro-Domains Identification
|
genomics
|
Drug-like small molecules that inhibit expression of the oncogenic microRNA-21
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biochemistry
|
A novel computational approach to identify cancer cells in scRNA-seq data
|
bioinformatics
|
Experimental Guidance for Discovering Genetic Networks through Iterative Hypothesis Reduction on Time Series
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systems biology
|
Genetic epidemiology of human neutrophil antigen variants suggest significant global variability
|
genomics
|
INPP5D limits plaque formation and glial reactivity in the APP/PS1 mouse model of Alzheimer's disease
|
neuroscience
|
Asynchronous excitatory neuron development in an isogenic cortical spheroid model of Down syndrome
|
neuroscience
|
Colour polymorphism associated with a gene duplication in male wood tiger moths
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evolutionary biology
|
Comparison of selective genotyping strategies in genomic selection programs for broilers using stochastic simulation
|
genetics
|
Bacterial plasmid-associated and chromosomal proteins have fundamentally different properties in protein interaction networks
|
genomics
|
Aggression and multimodal signaling in noise in the European robin
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animal behavior and cognition
|
Statistical correction of input gradients for black box models trained with categorical input features
|
bioinformatics
|
Identification of Key Genes and Biological Pathways in Bipolar Disorder by Bioinformatics and Next Generation Sequencing Data Analysis
|
bioinformatics
|
Deep Learning-based Pseudo-Mass Spectrometry Imaging Analysis for Precision Medicine
|
bioinformatics
|
Covalent Docking and Molecular Dynamics Simulations Reveal the Specificity-Shifting Mutations Ala237Arg and Ala237Lys in TEM Beta-Lactamase
|
bioinformatics
|
Tensor decomposition and principal component analysis-based unsupervised feature extraction outperforms state-of-the-art methods when applied to histone modification profiles
|
bioinformatics
|
microbeSEG: Accurate Cell Segmentation with OMERO Data Management
|
bioinformatics
|
The effect of external lateral stabilization on ankle moment control during steady-state walking
|
biophysics
|
Hypoxia-mediated regulation of DDX5 through decreased chromatin accessibility and post-translational targeting restricts R-loop accumulation
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cancer biology
|
Non-Invasive Cancer Detection in Canine Urine through C. elegans Chemotaxis
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cancer biology
|
Quantum pBac: An effective, high-capacity piggyBac-based gene integration vector system for unlocking gene therapy potential
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cancer biology
|
A new highly-specific Natural Killer cell-specific gene signature predicting recurrence in colorectal cancer patients.
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cancer biology
|
Uncovering Additional Predictors of Urothelial Carcinoma from Voided Urothelial Cell Clusters Through a Deep Learning Based Image Preprocessing Technique
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pathology
|
Characterization of metabolic changes associated with floral transition in Arabidopsis: RAFFINOSE SYNTHASE 5 contributes to determine the timing of floral transition
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plant biology
|
Leaf-level metabolic changes in response to drought affect daytime CO2 emission and isoprenoid synthesis
|
plant biology
|
Taxonomically Restricted Genes are Associated with Responses to Biotic and Abiotic Stresses in Sugarcane (Saccharum spp.)
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plant biology
|
In-situ energy budget of needle-leaves reveals shift from evaporative to 'air cooling' under drought
|
plant biology
|
A transcription factor module regulating stomatal formation is co-opted for the development of setae in the astomatous liverwort Marchantia polymorpha
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plant biology
|
A pipeline for assessing the quality of images and metadata from crowd-sourced databases.
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zoology
|
Concussive head trauma perturbs axon initial segment function in axotomized and intact layer 5 pyramidal neurons
|
neuroscience
|
Preserved executive control in ageing: The role of literacy experience
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neuroscience
|
Explaining and Predicting the Effects of Neurostimulation via Neuronal Excitation/Inhibition
|
neuroscience
|
Hippocampal cAMP-dependent synaptic potentiation, ERK-dependent immediate-early gene activation, and context-dependent fear conditioning in mice are linked through dependence on the guanine nucleotide exchange factor RapGEF2
|
neuroscience
|
Learning to suppress likely distractor locations in visual search is driven by the local distractor frequency
|
neuroscience
|
NMDA-receptor-Fc-fusion constructs neutralize anti- NMDA receptor antibodies
|
neuroscience
|
Recurrent neural network model of human event-related potentials in response to intensity oddball stimulation
|
neuroscience
|
An in situ quantitative map of initial human colorectal HIV transmission
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immunology
|
INFLAMMATION INDUCED DOWNREGULATION OF SUCCINATE DEHYDROGENASE REGULATES ADRENOCORTICAL FUNCTION
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immunology
|
The dual character of the inhibitory functions of CD6
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immunology
|
Genome-wide identification of SINA gene family in sugarcane and functional analysis of SsSINA1a in drought response
|
molecular biology
|
Sequential functional differentiation of luminal epithelial cells regulated by maternal and embryonic signaling in the mouse endometrium
|
cell biology
|
Cellular orientational fluctuations, rotational diffusion and nematic order under periodic driving
|
cell biology
|
Toxicology assessment of manganese oxide nanomaterials with enhanced electrochemical properties using human in vitro models representing different exposure routes
|
cell biology
|
A ratchet-like apical constriction drives cell ingression during the mouse gastrulation EMT
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developmental biology
|
A CXCL12 morphogen gradient uncovers lung endothelial heterogeneity and promotes distal vascular growth
|
developmental biology
|
Variant Polycomb complexes in Drosophila consistent with ancient functional diversity
|
developmental biology
|
Long-term population decline of a genetically homogenous continental-wide top Arctic predator
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ecology
|
Heterogeneity of Interaction Strengths and Its Consequences on Ecological Systems
|
ecology
|
Evolution is not uniform along protein sequences
|
evolutionary biology
|
Distinct Effects of the Male-Killing Bacteria Wolbachia and Spiroplasma and a Partiti-Like Virus in the Tea Pest Moth, Homona magnanima
|
evolutionary biology
|
Leveraging spatio-temporal genomic breeding value estimates of dry matter yield and herbage quality in ryegrass via random regression models
|
genetics
|
An automated approach to quantify chemotaxis index in Caenorhabditis nematodes
|
genetics
|
Hybridization drives mitochondrial DNA degeneration and metabolic shift in a species with biparental mitochondrial inheritance
|
genomics
|
Heritability of Urinary Amines, Organic Acids, and Steroid Hormones in Children
|
genomics
|
Qualification of Identity, Quality-Attribute Monitoring and New Peak Detection in An Improved Multi-Attribute Method with Lys-C Digestion for Characterization and Quality Control of Therapeutic Monoclonal Antibodies
|
biochemistry
|
Deep mutational scanning and machine learning reveal structural and molecular rules governing allosteric hotspots in homologous proteins
|
biochemistry
|
Magnetic Enrichment of Immuno-Specific Extracellular Vesicles for Mass Spectrometry Using Biofilm-Derived Iron Oxide Nanowires
|
bioengineering
|
Imaging the structure and dynamic activity of retinal microglia and macrophage-like cells in the living human eye
|
bioengineering
|
Rebound Excitation of Epileptiform Activities by Transcranial Focused Ultrasound Stimulation
|
bioengineering
|
A new computational framework like Google identifies therapeutic targets based on machine learning unveiling influential genes in pancreatic islet cells
|
bioinformatics
|
The reprogrammed mouse heart phosphoproteome in response to the chronic stress of markedly high cardiac-specific adenylyl cyclase type 8 overexpression
|
bioinformatics
|
A deep learning framework for structural variant discovery and genotyping
|
bioinformatics
|
Single cell transcriptional landscape of long non-coding RNAs orchestrating mouse heart development
|
bioinformatics
|
DysRegNet: Patient-specific and confounder-aware dysregulated network inference
|
bioinformatics
|
Effects of Full-cycle Exposure to Difenoconazole in Parental Zebrafish on the Liver-gut Axis of F0 and F1 Generations
|
bioinformatics
|
Evaluating deep learning for predicting epigenomic profiles
|
bioinformatics
|
Robust Normalization and Integration of Single-cell Protein Expression across CITE-seq Datasets
|
bioinformatics
|
Changes in protonation states of in-pathway residues can alter ligand binding pathways obtained from spontaneous binding molecular dynamics simulations
|
biophysics
|
Transcription-induced active forces suppress chromatin motion by inducing a transient disorder-to-order transition
|
biophysics
|
Compressive stress drives adhesion-dependent unjamming transitions in breast cancer cell migration
|
biophysics
|
Sexually dimorphic activation of innate antitumour immunity prevents adrenocortical carcinoma development
|
cancer biology
|
Glutamine is essential for overcoming theimmunosuppressive microenvironment in malignant salivary gland tumors
|
cancer biology
|
TME induced TRAIL secretion from engineered macrophages for anti-tumor therapy
|
cancer biology
|
Increased glucose availability sensitizes pancreatic cancer to chemotherapy
|
cancer biology
|
BRCA1 Hypermethylation In Sporadic Breast Cancers: Discovering A Novel Pathway To Tumorigenesis Via Coordinate NBR2 Deregulation And TNBC Transformation
|
cancer biology
|
Isotope-based visualization of element distribution in phloem provides functional evidence for the operation of SOS1 Na+/H+ exchangers in mature zones of Arabidopsis root
|
plant biology
|
Modelling mouse auditory response dynamics along a continuum of consciousness using a deep recurrent neural network
|
neuroscience
|
Beneficial effects of cellular coinfection resolve inefficiency in influenza A virus transcription
|
microbiology
|
Inter-organ Wingless/Ror/Akt signaling regulates nutrient-dependent hyperarborization of somatosensory neurons
|
developmental biology
|
Tree diversity and density affect damage caused by the invasive pest Cameraria ohridella in urban areas
|
ecology
|
Discordant effects of resource limitation on host survival and systemic pathogen growth in Drosophila-bacteria infection models: resistance vs. tolerance
|
ecology
|
Phylogenomics provides insights into the evolution of cactophily and host plant shifts in Drosophila
|
evolutionary biology
|
Gene expression signatures underlying inbreeding depression as revealed by whole-transcriptome analysis of selectively bred strains of the Pacific Oyster (Crassostrea gigas)
|
genomics
|
Combined MD and QM/MM Calculations reveal Allostery Driven Promiscuity in Dipeptide Epimerases of Enolase Family
|
biochemistry
|
Boosting polygenic risk scores
|
bioinformatics
|
Transcriptome analysis reveals hepatotoxicity in zebrafish induced by cyhalofop-butyl
|
bioinformatics
|
HiCognition: a visual exploration and hypothesis testing tool for 3D genomics
|
bioinformatics
|
Exploratory Meta-Analysis of Hypoxic Transcriptomes Using a Precise Transcript Reference Sequence Set
|
bioinformatics
|
ChemPert: mapping between chemical perturbation and transcriptional response for non-cancer cells
|
bioinformatics
|
A mutation-level covariate model for mutational signatures
|
bioinformatics
|
PanCircBase: An online resource for the exploration of circular RNAs in pancreatic islets
|
bioinformatics
|
A DNA segregation module for synthetic cells
|
biophysics
|
The Breast Cancer Epigenomics Track Hub
|
cancer biology
|
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