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Dynamic tripartite construct of interregional engram circuits underlies forgetting of extinction memory
neuroscience
Goal-driven optimization of single-neuron properties in artificial networks reveals regularization role of neural diversity and adaptation
neuroscience
Differential activation of NLRP3 inflammasome by Acinetobacter baumannii strains
microbiology
Genomic, transcriptomic and proteomic depiction of iPSC-derived smooth muscle cells as emerging cellular models for arterial diseases
cell biology
Genetic architecture of spatially complex color patterning in hybrid Mimulus
genetics
Unifying genomics and transcriptomics in single cells with ResolveOME amplification chemistry to illuminate oncogenic and drug resistance mechanisms
genomics
Activation Of Transposable Elements Upon Statin Treatment
bioinformatics
Elevator mechanism dynamics in a sodium-coupled dicarboxylate transporter
biophysics
Generic solving of physiologically-based kinetic models in support of next generation risk assessment due to chemicals
pharmacology and toxicology
Synthetic Mechanotransduction Using Engineered SynNotch Receptors
synthetic biology
A role for the anterior hippocampus in autobiographical memory construction regardless of temporal distance
neuroscience
Characterization of Extensive Diversity In Immunoglobulin Light Chain Variable Germline Genes Across Biomedically Important Mouse Strains
immunology
Metabarcoding metacommunities: time, space, and land use interact to structure aquatic macroinvertebrate communities in streams
ecology
Role of aIF5B in archaeal translation initiation
biochemistry
One-Pot Endonucleolytically Exponentiated Rolling Circle Amplification by CRISPR-Cas12a Affords Sensitive, Expedited Isothermal Detection of MicroRNAs
bioengineering
Microbial metabolite butyrate-prodrug polymeric micelles promote gut health and treat food allergies
bioengineering
Building a knowledge graph to enable precision medicine
bioinformatics
Lithium orotate is more potent, effective, and less toxic than lithium carbonate in a mouse model of mania
pharmacology and toxicology
Impatiens banen sp. nov. & I. etugei sp. nov. (Balsaminaceae), threatened lowland species of the Cross-Sanaga Interval, Cameroon
plant biology
Light-dependent modulation of protein localization and function in living bacteria cells
synthetic biology
Coordinated control of neuronal differentiation and wiring by a sustained code of transcription factors
neuroscience
Fc-engineered antibodies leverage neutrophils to drive control of Mycobacterium tuberculosis
immunology
A transcriptional mechanism involving R-loop, m6A modification and RNA abasic sites regulates an enhancer RNA of APOE.
molecular biology
RNA exosome ribonuclease DIS3 degrades Pou6f1 to promote mouse pre-implantation cell differentiation
developmental biology
Staining-Free, In-Flow Enumeration of Tumor Cells in Blood Using Digital Holographic Microscopy and Deep Learning
bioengineering
How to Best Represent Proteins in Machine Learning-based Prediction of Drug/Compound-Target Interactions
bioinformatics
Differential regulation of GUV mechanics via actin network architectures
biophysics
Immune defense in Drosophila melanogaster depends on diet, sex, and mating status
physiology
The capsid precursor protein of astrovirus VA1 is proteolytically processed intracellularly
microbiology
CORK1, a LRR-Malectin Receptor Kinase for Cellooligomer Perception in Arabidopsis thaliana
plant biology
Decoding violated sensory expectations from the auditory cortex of anaesthetized mice: Hierarchical recurrent neural network depicts separate 'danger' and 'safety' units
neuroscience
Human Lung-resident Mucosal-Associated Invariant T cells are Abundant, Express Antimicrobial Proteins, and are Cytokine Responsive
immunology
Decreased in vitro dihydroartemisinin sensitivity in malaria parasites infecting sickle cell disease patients
microbiology
Shock or jump: deimatic behaviour is repeatable and polymorphic in a yellow-bellied toad
ecology
Interphotoreceptor matrix proteoglycans IMPG1 and IMPG2 proteolyze in the SEA domain and reveal localization mutual dependency
molecular biology
The Medicines for Malaria Venture Malaria Box contains inhibitors of protein secretion in Plasmodium falciparum blood stage parasites
biochemistry
A Simulator for Somatic Evolution Study Design
bioinformatics
Genomic characteristics and clinical significance of CD56+ Circulating Tumor Cells in Small Cell Lung Carcinoma
cancer biology
Ex vivo to in vivo model of malignant peripheral nerve sheath tumors for precision oncology
cancer biology
Repeated birth injuries lead to pelvic floor muscle dysfunction and impairment in regeneration
physiology
Biomechanics and hydraulics of Opuntia ficus-indica roots exposed to extreme drought
plant biology
Uncovering molecular iron compounds in the living human brain.
neuroscience
Longitudinal 7T MRI reveals volumetric changes in subregions of human medial temporal lobe to sex hormone fluctuations
neuroscience
Decoding of Speech Information using EEG in Children with Dyslexia: Less Accurate Low-Frequency Representations of Speech, Not "Noisy" Representations
neuroscience
Angiotensin II regulates the neural expression of subjective fear in humans
neuroscience
Optimal Control Costs of Brain State Transitions in Linear Stochastic Systems
neuroscience
Temporal changes in the microglial proteome of male and female mice after a diffuse brain injury using label-free quantitative proteomics
neuroscience
Minute-scale oscillatory sequences in medial entorhinal cortex
neuroscience
GD2-targeting CAR-T cells enhanced by transgenic IL-15 expression are an effective and clinically feasible therapy for glioblastoma
immunology
Inferring the T-cells repertoire dynamics of healthy individuals
immunology
Spatial, Quantitative and Functional Deconstruction of Virus and Host Protein Interactions Inside Intact Cytomegalovirus Particles
microbiology
Accelerated aging induced by stress in experimental murine ocular hypertension.
molecular biology
Essential oils of plants and their combinations as an alternative adulticides against Anopheles gambiae (Diptera: Culicidae) populations.
ecology
Genetic modification of the ant Lasius niger using CRISPR-Cas9 technology
genetics
20 years of misunderstanding: compensatory traits can explain U-shaped cost function of purely sexual traits
animal behavior and cognition
Atomic model of Vesicular Stomatitis Virus and Mechanism of Assembly
biochemistry
Structure of V-ATPase from citrus fruit
biochemistry
Engineering cell morphology by CRISPR interference in Acinetobacter baylyi ADP1
bioengineering
The Rosenbluth sampling Calculation of Hydrophobic-Polar Model
bioinformatics
Interpretable deep learning to uncover the molecular binding patterns determining TCR-epitope interactions
bioinformatics
A de novo MS1 feature detector for the Bruker timsTOF Pro
bioinformatics
Resolution of the curse of dimensionality in single-cell RNA sequencing data analysis
bioinformatics
Displacement and dissociation of oligonucleotidesduring DNA hairpin closure under strain
biophysics
Mechanical communication-induced cell directional migration and branching connections mediated by calcium channels, integrin β1 and N-cadherin
biophysics
Distinct Mechanisms of Innate and Adaptive Immune Regulation Underlie Poor Oncologic Outcomes Associated with KRAS-TP53 Co-Alteration in Pancreatic Cancer
cancer biology
An Integrated 3D bioprinted disease in a dish lung cancer model to simultaneously study drug efficacy, toxicity and metabolism
pharmacology and toxicology
Modelling somatic mutation accumulation and expansion in a long-lived tree with hierarchical modular architecture
plant biology
Neurocomputational evidence that conflicting prosocial motives guide distributive justice
neuroscience
Widespread employment of conserved C. elegans homeobox genes in neuronal identity specification
neuroscience
Inhibition of c-Jun in AgRP neurons mediates chronic stress-induced anxiety-like behaviors and colitis susceptibility
neuroscience
Choosing memory retrieval strategies: a critical role for inhibition in the dentate gyrus
neuroscience
CSF circulation and dispersion yield rapid clearancefrom intracranial compartments
neuroscience
PfHDAC1 is an essential regulator of parasite asexual growth with its altered genomic occupancy and activity associated with artemisinin drug resistance in Plasmodium falciparum
microbiology
Minimal functional domains of the core polarity regulator Dlg
developmental biology
Consistency in defence and competitiveness trade-off in a planktonic predator-prey system
ecology
MITE infestation of germline accommodated by genome editing in Blepharisma
genomics
Associations of human femoral condyle cartilage structure and composition with viscoelastic and constituent-specific material properties at different stages of osteoarthritis
biophysics
Translational approach to increase phosphate accumulation in two plant species through perturbance of inositol pyrophosphates
plant biology
The transcription factor RUNX2 drives the generation of human NK cells and promotes tissue residency
immunology
Integrated viral elements unveil the dual lifestyle of Tetraselmis spp. polinton-like viruses
microbiology
Dauer quiescence as well as continuity of the life cycle after dauer-exit in Caenorhabditis elegans are dependent on the endoribonuclease activity of XRN-2
molecular biology
Loss of mitochondrial Chchd10 or Chchd2 in zebrafish leads to an ALS-like phenotype and Complex I deficiency independent of the mt-ISR
developmental biology
Microbiome signatures in Acropora cervicornis are associated with genotypic resistance to elevated nutrients and heat stress
ecology
Heterologously secreted MbxA from Moraxella bovis induces a membrane blebbing response of the human host cell
biochemistry
SARS-CoV-2 Main Protease: a Kinetic Approach
biophysics
Quantitative analysis of neuroligin-3 expression in the enteric nervous system of the Neuroligin-3R451C mouse model of autism
neuroscience
BA.2.12.1, BA.4 and BA.5 escape antibodies elicited by Omicron infection
immunology
Comparative computational structural genomics highlights divergent evolution of fungal effectors
microbiology
The highly conserved stem-loop II motif is important for the lifecycle of astroviruses but dispensable for SARS-CoV-2
microbiology
Nsp1 proteins of human coronaviruses HCoV-OC43 and SARS-CoV2 inhibit stress granule formation
microbiology
Relationships of Worldwide Onobrychis species: from seed & pod morphology and molecular perspective
evolutionary biology
Visualizing the Coordination of APE1 and DNA Polymerase β During Base Excision Repair
biochemistry
Improving the RNA velocity approach using long-read single cell sequencing
bioinformatics
Mechanically primed cells transfer memory to fibrous matrices for persistent invasion
biophysics
Expression of YAP1-MAML2 and constitutively active YAP1 drive the formation of meningioma-like tumors in mice that resemble NF2-mutant meningiomas
cancer biology
Ultradeep characterisation of translational sequence determinants refutes rare-codon hypothesis and unveils quadruplet base pairing of initiator tRNA and transcript
synthetic biology
Syntaxin Habc is required to open Unc18 to template SNARE assembly
neuroscience
Effects of the investigational drug sodium phenylbutyrate-TUDCA (AMX0035) on the transcriptional and metabolic landscape of sporadic ALS fibroblasts
neuroscience
Genetic and pharmacological reduction of CDK14 mitigates synucleinopathy
neuroscience
An Epitope-Focused Trypanosome-Derived Vaccine Platform Elicits High-Affinity Antibodies and Immunity Against Fentanyl Effects
immunology