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Dynamic tripartite construct of interregional engram circuits underlies forgetting of extinction memory
|
neuroscience
|
Goal-driven optimization of single-neuron properties in artificial networks reveals regularization role of neural diversity and adaptation
|
neuroscience
|
Differential activation of NLRP3 inflammasome by Acinetobacter baumannii strains
|
microbiology
|
Genomic, transcriptomic and proteomic depiction of iPSC-derived smooth muscle cells as emerging cellular models for arterial diseases
|
cell biology
|
Genetic architecture of spatially complex color patterning in hybrid Mimulus
|
genetics
|
Unifying genomics and transcriptomics in single cells with ResolveOME amplification chemistry to illuminate oncogenic and drug resistance mechanisms
|
genomics
|
Activation Of Transposable Elements Upon Statin Treatment
|
bioinformatics
|
Elevator mechanism dynamics in a sodium-coupled dicarboxylate transporter
|
biophysics
|
Generic solving of physiologically-based kinetic models in support of next generation risk assessment due to chemicals
|
pharmacology and toxicology
|
Synthetic Mechanotransduction Using Engineered SynNotch Receptors
|
synthetic biology
|
A role for the anterior hippocampus in autobiographical memory construction regardless of temporal distance
|
neuroscience
|
Characterization of Extensive Diversity In Immunoglobulin Light Chain Variable Germline Genes Across Biomedically Important Mouse Strains
|
immunology
|
Metabarcoding metacommunities: time, space, and land use interact to structure aquatic macroinvertebrate communities in streams
|
ecology
|
Role of aIF5B in archaeal translation initiation
|
biochemistry
|
One-Pot Endonucleolytically Exponentiated Rolling Circle Amplification by CRISPR-Cas12a Affords Sensitive, Expedited Isothermal Detection of MicroRNAs
|
bioengineering
|
Microbial metabolite butyrate-prodrug polymeric micelles promote gut health and treat food allergies
|
bioengineering
|
Building a knowledge graph to enable precision medicine
|
bioinformatics
|
Lithium orotate is more potent, effective, and less toxic than lithium carbonate in a mouse model of mania
|
pharmacology and toxicology
|
Impatiens banen sp. nov. & I. etugei sp. nov. (Balsaminaceae), threatened lowland species of the Cross-Sanaga Interval, Cameroon
|
plant biology
|
Light-dependent modulation of protein localization and function in living bacteria cells
|
synthetic biology
|
Coordinated control of neuronal differentiation and wiring by a sustained code of transcription factors
|
neuroscience
|
Fc-engineered antibodies leverage neutrophils to drive control of Mycobacterium tuberculosis
|
immunology
|
A transcriptional mechanism involving R-loop, m6A modification and RNA abasic sites regulates an enhancer RNA of APOE.
|
molecular biology
|
RNA exosome ribonuclease DIS3 degrades Pou6f1 to promote mouse pre-implantation cell differentiation
|
developmental biology
|
Staining-Free, In-Flow Enumeration of Tumor Cells in Blood Using Digital Holographic Microscopy and Deep Learning
|
bioengineering
|
How to Best Represent Proteins in Machine Learning-based Prediction of Drug/Compound-Target Interactions
|
bioinformatics
|
Differential regulation of GUV mechanics via actin network architectures
|
biophysics
|
Immune defense in Drosophila melanogaster depends on diet, sex, and mating status
|
physiology
|
The capsid precursor protein of astrovirus VA1 is proteolytically processed intracellularly
|
microbiology
|
CORK1, a LRR-Malectin Receptor Kinase for Cellooligomer Perception in Arabidopsis thaliana
|
plant biology
|
Decoding violated sensory expectations from the auditory cortex of anaesthetized mice: Hierarchical recurrent neural network depicts separate 'danger' and 'safety' units
|
neuroscience
|
Human Lung-resident Mucosal-Associated Invariant T cells are Abundant, Express Antimicrobial Proteins, and are Cytokine Responsive
|
immunology
|
Decreased in vitro dihydroartemisinin sensitivity in malaria parasites infecting sickle cell disease patients
|
microbiology
|
Shock or jump: deimatic behaviour is repeatable and polymorphic in a yellow-bellied toad
|
ecology
|
Interphotoreceptor matrix proteoglycans IMPG1 and IMPG2 proteolyze in the SEA domain and reveal localization mutual dependency
|
molecular biology
|
The Medicines for Malaria Venture Malaria Box contains inhibitors of protein secretion in Plasmodium falciparum blood stage parasites
|
biochemistry
|
A Simulator for Somatic Evolution Study Design
|
bioinformatics
|
Genomic characteristics and clinical significance of CD56+ Circulating Tumor Cells in Small Cell Lung Carcinoma
|
cancer biology
|
Ex vivo to in vivo model of malignant peripheral nerve sheath tumors for precision oncology
|
cancer biology
|
Repeated birth injuries lead to pelvic floor muscle dysfunction and impairment in regeneration
|
physiology
|
Biomechanics and hydraulics of Opuntia ficus-indica roots exposed to extreme drought
|
plant biology
|
Uncovering molecular iron compounds in the living human brain.
|
neuroscience
|
Longitudinal 7T MRI reveals volumetric changes in subregions of human medial temporal lobe to sex hormone fluctuations
|
neuroscience
|
Decoding of Speech Information using EEG in Children with Dyslexia: Less Accurate Low-Frequency Representations of Speech, Not "Noisy" Representations
|
neuroscience
|
Angiotensin II regulates the neural expression of subjective fear in humans
|
neuroscience
|
Optimal Control Costs of Brain State Transitions in Linear Stochastic Systems
|
neuroscience
|
Temporal changes in the microglial proteome of male and female mice after a diffuse brain injury using label-free quantitative proteomics
|
neuroscience
|
Minute-scale oscillatory sequences in medial entorhinal cortex
|
neuroscience
|
GD2-targeting CAR-T cells enhanced by transgenic IL-15 expression are an effective and clinically feasible therapy for glioblastoma
|
immunology
|
Inferring the T-cells repertoire dynamics of healthy individuals
|
immunology
|
Spatial, Quantitative and Functional Deconstruction of Virus and Host Protein Interactions Inside Intact Cytomegalovirus Particles
|
microbiology
|
Accelerated aging induced by stress in experimental murine ocular hypertension.
|
molecular biology
|
Essential oils of plants and their combinations as an alternative adulticides against Anopheles gambiae (Diptera: Culicidae) populations.
|
ecology
|
Genetic modification of the ant Lasius niger using CRISPR-Cas9 technology
|
genetics
|
20 years of misunderstanding: compensatory traits can explain U-shaped cost function of purely sexual traits
|
animal behavior and cognition
|
Atomic model of Vesicular Stomatitis Virus and Mechanism of Assembly
|
biochemistry
|
Structure of V-ATPase from citrus fruit
|
biochemistry
|
Engineering cell morphology by CRISPR interference in Acinetobacter baylyi ADP1
|
bioengineering
|
The Rosenbluth sampling Calculation of Hydrophobic-Polar Model
|
bioinformatics
|
Interpretable deep learning to uncover the molecular binding patterns determining TCR-epitope interactions
|
bioinformatics
|
A de novo MS1 feature detector for the Bruker timsTOF Pro
|
bioinformatics
|
Resolution of the curse of dimensionality in single-cell RNA sequencing data analysis
|
bioinformatics
|
Displacement and dissociation of oligonucleotidesduring DNA hairpin closure under strain
|
biophysics
|
Mechanical communication-induced cell directional migration and branching connections mediated by calcium channels, integrin β1 and N-cadherin
|
biophysics
|
Distinct Mechanisms of Innate and Adaptive Immune Regulation Underlie Poor Oncologic Outcomes Associated with KRAS-TP53 Co-Alteration in Pancreatic Cancer
|
cancer biology
|
An Integrated 3D bioprinted disease in a dish lung cancer model to simultaneously study drug efficacy, toxicity and metabolism
|
pharmacology and toxicology
|
Modelling somatic mutation accumulation and expansion in a long-lived tree with hierarchical modular architecture
|
plant biology
|
Neurocomputational evidence that conflicting prosocial motives guide distributive justice
|
neuroscience
|
Widespread employment of conserved C. elegans homeobox genes in neuronal identity specification
|
neuroscience
|
Inhibition of c-Jun in AgRP neurons mediates chronic stress-induced anxiety-like behaviors and colitis susceptibility
|
neuroscience
|
Choosing memory retrieval strategies: a critical role for inhibition in the dentate gyrus
|
neuroscience
|
CSF circulation and dispersion yield rapid clearancefrom intracranial compartments
|
neuroscience
|
PfHDAC1 is an essential regulator of parasite asexual growth with its altered genomic occupancy and activity associated with artemisinin drug resistance in Plasmodium falciparum
|
microbiology
|
Minimal functional domains of the core polarity regulator Dlg
|
developmental biology
|
Consistency in defence and competitiveness trade-off in a planktonic predator-prey system
|
ecology
|
MITE infestation of germline accommodated by genome editing in Blepharisma
|
genomics
|
Associations of human femoral condyle cartilage structure and composition with viscoelastic and constituent-specific material properties at different stages of osteoarthritis
|
biophysics
|
Translational approach to increase phosphate accumulation in two plant species through perturbance of inositol pyrophosphates
|
plant biology
|
The transcription factor RUNX2 drives the generation of human NK cells and promotes tissue residency
|
immunology
|
Integrated viral elements unveil the dual lifestyle of Tetraselmis spp. polinton-like viruses
|
microbiology
|
Dauer quiescence as well as continuity of the life cycle after dauer-exit in Caenorhabditis elegans are dependent on the endoribonuclease activity of XRN-2
|
molecular biology
|
Loss of mitochondrial Chchd10 or Chchd2 in zebrafish leads to an ALS-like phenotype and Complex I deficiency independent of the mt-ISR
|
developmental biology
|
Microbiome signatures in Acropora cervicornis are associated with genotypic resistance to elevated nutrients and heat stress
|
ecology
|
Heterologously secreted MbxA from Moraxella bovis induces a membrane blebbing response of the human host cell
|
biochemistry
|
SARS-CoV-2 Main Protease: a Kinetic Approach
|
biophysics
|
Quantitative analysis of neuroligin-3 expression in the enteric nervous system of the Neuroligin-3R451C mouse model of autism
|
neuroscience
|
BA.2.12.1, BA.4 and BA.5 escape antibodies elicited by Omicron infection
|
immunology
|
Comparative computational structural genomics highlights divergent evolution of fungal effectors
|
microbiology
|
The highly conserved stem-loop II motif is important for the lifecycle of astroviruses but dispensable for SARS-CoV-2
|
microbiology
|
Nsp1 proteins of human coronaviruses HCoV-OC43 and SARS-CoV2 inhibit stress granule formation
|
microbiology
|
Relationships of Worldwide Onobrychis species: from seed & pod morphology and molecular perspective
|
evolutionary biology
|
Visualizing the Coordination of APE1 and DNA Polymerase β During Base Excision Repair
|
biochemistry
|
Improving the RNA velocity approach using long-read single cell sequencing
|
bioinformatics
|
Mechanically primed cells transfer memory to fibrous matrices for persistent invasion
|
biophysics
|
Expression of YAP1-MAML2 and constitutively active YAP1 drive the formation of meningioma-like tumors in mice that resemble NF2-mutant meningiomas
|
cancer biology
|
Ultradeep characterisation of translational sequence determinants refutes rare-codon hypothesis and unveils quadruplet base pairing of initiator tRNA and transcript
|
synthetic biology
|
Syntaxin Habc is required to open Unc18 to template SNARE assembly
|
neuroscience
|
Effects of the investigational drug sodium phenylbutyrate-TUDCA (AMX0035) on the transcriptional and metabolic landscape of sporadic ALS fibroblasts
|
neuroscience
|
Genetic and pharmacological reduction of CDK14 mitigates synucleinopathy
|
neuroscience
|
An Epitope-Focused Trypanosome-Derived Vaccine Platform Elicits High-Affinity Antibodies and Immunity Against Fentanyl Effects
|
immunology
|
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