text
stringlengths 164
66.8k
|
|---|
Die vorgestellte Studie ist eine monozentrische, retrospektive Datenerhebung aller Patienten, die am LMU-Klinikum bis zum 31.07.2020 intensivmedizinisch aufgrund von COVID-19 behandelt wurden. Die ansässige Ethikkommission stimmte der Datenerhebung und -auswertung zu (CORKUM, WHO trial ID DRKS00021225).
|
Higher gut microbial species diversity is generally linked to more functional redundancy and better health (29). A more diverse diet may create a more varied nutritional habitat in the gut favoring a wider range of microbial taxa (50). Our results showed that the alpha diversity of gut microbial community of Brandt’s voles consistently increased with a higher DSR diet. According to the phylogenetic analysis, stochastic processes dominated microbial community assemblages in the vole gut ecosystem in a low DSR diet. However, after the addition of nonpreferred plant species into the vole diet, deterministic processes tended to intensify. This pattern is assumed to be largely the result of changes in sIgA and prebiotics content (e.g., resistant starch and fructo-oligosaccharides or FOS) with the increase of DSR of diets. The sIgA and prebiotics may play essential roles in determining which bacteria colonize the gut. For example, sIgA antibodies can bind to Salmonella typhimurium and inhibit Salmonella invasion (47). Moreover, resistant starch supplementation can promote the growth of Bifidobacterium adolescentis and Ruminococcus bromii and thus increase butyrate production (51). High FOS consumption can elevate the relative abundance of probiotic microbes (e.g., Bifidobacterium and Lactobacillus) and butyrate-producing microbes such as Oscillospira, Ruminococcus and Faecalibacterium (52).
|
Secondary HLH is associated with hematological malignancies, viral infection, and rheumatic disease, with the latter being termed as macrophage activation syndrome (MAS)) . Ramos-Casals et al. detailed 2197 adult HLH cases between 1974 and 2011 and identified HLH associated with an infectious trigger in 50.4%, malignant trigger in 47.7%, autoimmune trigger in 12.6% and an unknown trigger in 3.7%. Nearly one third of cases had more than one underlying cause . Hematologic malignancies such as lymphomas, T/NK-cell disorders, acute leukemias, lymphoproliferative diseases, and myelodysplastic syndrome, are the most common triggers of malignancy derived HLH . Interestingly, EBV is a frequent co-trigger affecting 24% of patients and 88% of patients during chemotherapy . Chemotherapeutic triggers cell lysis and necrosis, resulting in a release of IL-5, IL-13, IL-10, IL-6, TNF-α, IFN-γ and IL-1β, further potentiated by tumor infiltrating lymphocytes . Chemotherapy can also increase underlying single nucleotide polymorphism or subclinical mutation leading to development of HLH .
|
The Japanese-language version of the Impact of Event Scale—Revised (IES-R-J) (14) was used to evaluate PTSD from the Great East Japan Earthquakes. This questionnaire consisted of 22 questions in three subscales, including intrusion items, avoidance items, and hyperarousal items, and utilized five-point scales (0–4) for each question, leading to development of a composite PTSD score. A cutoff value of 24/25 in total score was used to define clinically concerning PTSD and partial PTSD (14). The respondents were asked to answer how strong (0–4 scale) they recalled feeling about items in the questionnaire 1 month after the disaster and at the time of the event (i.e., 4.4 years after the disaster).
|
The norm-related BOLD signals were found in the ventral striatum ([10, 16, -2]) for the Controllable condition, and in the right anterior insula ([28, 16, -6]) and the amygdala ([18, -6, -8]) for the Uncontrollable condition at PFWE <.05, small volume corrected. However, the whole brain contrast showed no difference between the conditions. Figure 5—figure supplement 4 was displayed at P <.01, uncorrected, k > 50.
|
Insect neuropeptides act as neuromodulators in the central and peripheral nervous system, as well as regulatory hormones released into the circulation. The functional roles of insect neuropeptides include regulation of homeostasis, organization of behaviors, initiation and modulation of neuronal and muscular activity and coordination of developmental processes and reproduction . In the malaria mosquito Anopheles gambiae, at least 35 genes encoding peptide precursors and 40 putative peptide G-protein-coupled receptors (GPCRs) were identified . In the Aedes aegypti genome 43 neuropeptides , and over 40 GPCRs have been described.
|
Dans notre étude, le taux moyen de l'HVG (71,05%). C'est le cas de Bah A. O. et al. en 2006 en République de Guinée (72,95%) et tout récemment de A. Aldlouni et al. en 2011 au Maroc (87%) . Ce taux élevé d'HVG s'explique par la fréquence de l'anémie, de l'HTA et de la prise de poids excessive chez ces patients. Une attention particulière sera accordée au suivi de l'anémie et de l'HTA d'autant plus qu'ils ont été identifiés comme déterminants majeurs de la survenue de l'HVG. Ce fait a été aussi rapporté par Eba A., Aghrabat M.S. en 2006 en Mauritanie . Il en est de même de la FAV proximale à haut débit qui est reconnue comme un facteur favorisant l'HVG [5, 6]. Statistiquement ceci conforte les résultats de notre étude. Parmi nos 8 patients qui avaient une FAV proximale, 4 avaient un hyperdébit. Au cours du suivi, la proportion des troubles de la repolarisation étaient retrouvés chez 13 patients soit 34,21% avec un âge moyen de 50,4 ans. Ce résultat est similaire à ceux retrouvés par SABOURI où l’âge moyen était de 55,7 ans. Dans la littérature comme le rapporte l’étude de B. CHARRA , la prévalence élevée de l'hypertrophie ventriculaire gauche, de l'hypertension artérielle et du diabète chez les hémodialysés est à l'origine d'une maladie coronaire souvent silencieuse et associée à des troubles de la repolarisation non spécifiques sur l'ECG de repos. Ceci conforte notre étude où nous avons établi une corrélation significative entre l'HVG et la survenue des troubles de la repolarisation. Cependant, il n'y avait pas de corrélation entre les troubles de la repolarisation et le diabète ainsi qu'avec l'HTA avec une différence non significative dans les 2 cas ce qui s'explique entre autres par la faible taille de l’échantillon. Ce constat va à l'encontre des résultats d'autres études qui ont recherché les facteurs de risque cardio-vasculaires chez l'hémodialysé. Notamment TAKEDA et Al. au Japon, qui ont démontré que le risque de survenue de nouveaux évènements cardio-vasculaires était fortement lié à l'HTA (p< 0,0005).
|
In the injured leg (right), there were improvements in gastrocnemius medialis MT (~10%) and PA (~12.7%), as measured by US, which appeared to be reflected by the relative improvement in Dm (~47%) and, to a lesser extent, Tc (~6.7%). These findings were expected, as they mirror improvements in muscle size and function in response to resistance exercise . Strength increases prior to changes in muscle size and is usually proportionally greater, i.e., modest gains in muscle size are usually associated with 3–4 times the relative strength gains . In the early stages of resistance training, this is suggested to be as a result of an increase in the neural drive to muscle . Häkkinen and colleagues reported the largest motor units to be recruited within the first 7 weeks of resistance training . The force output of a muscle increases in response to the number of sarcomeres in parallel. An increase in PA facilitates more sarcomeres in parallel, i.e., an increase in physiological cross-sectional area (CSA) without a change in anatomical CSA . It is likely that the increase in PA and the overall increase in contractile mass (MT) contributed to the increase in Dm reported in this athlete. However, Dm is not a measure of force but of stiffness and therefore, it is likely to be heavily influenced by the tendon aponeurosis complex and intramuscular connective tissue. These are the structures which transfer muscle force to the bone. Increases in musculotendinous stiffness have previously been reported in response to resistance training and likely contribute to changes reported in Dm. These changes in connective tissue stiffness are thought to be primarily driven by an increase in type I collagen synthesis .
|
The replication of PyV genomes occurs in close proximity to PML NBs.During infection, PML NBs increase in size and number and their composition changes.In MCPyV infection, Sp100 was found to negatively influence viral transcription.In JCPyV infection, particle formation was detected at the surface of PML NBs.
|
As oxidative stress is well established as associated with inflammation, we examined CaD effects on ROS. Specifically, NADPH oxidase is accepted as the most important inducer of phagocytic cell generation of ROS (especially H2O2), which acts as a second messenger in activating signaling pathways that induce monocyte adhesion, invasion, and migration in atherosclerosis . ROS is also implicated in various cell signaling processes, including monocyte-to-macrophage differentiation , via glucose or PMA activation of PKC/MAPK signaling ; this is suppressed by antioxidants, such as curcumin, NAC, vitamin E, and vitamin C . Additionally, CaD is a potent antioxidant in both in vitro and in vivo animal models , although its exact mechanism is not fully elucidated. In the present study, we found that the ROS scavenger NAC and the NADPH oxidase inhibitor DPI inhibited CD14, TLR4, and MMP-9 expression in PMA-treated cells, while also demonstrating that CaD markedly suppressed ROS production during PMA-induced THP-1 differentiation. This is the first report of ROS modulating CD14 expression in human macrophages to the best of our knowledge. Recently, Akhter et al. reported that treatment of peripheral blood mononuclear cells with H2O2 induced TLR4 expression via ROS production , which also upregulates macrophage MMP-9 expression and cell migration . These findings clearly show that CaD modulated monocyte-to-macrophage differentiation and inflammation via ROS scavenging.
|
A total of 1700 schoolchildren were approached, of which 1627 (response rate = 95.7%) accepted to respond to the questionnaire. Of those that responded, 16 were excluded for incomplete questionnaires. Therefore, the responses from 1611 (860 girls and 751 boys) were included in the analyses.
|
Na análise bruta, observaram-se que a idade (oddsratio de 0,48; intervalo de confiança de IC95%: 0,24- 0,97) foi associada à desistência, já que adolescentes >15 anos apresentaram chance 0,48 menor de aderir ao programa, em comparação aos mais novos (Tabela 2).
|
13. DESENDER, K., ALDERWEIRELDT, M., DE KEER, R., POLLET, M., 1988. Ecologisch onderzoek naar het voorkomen, de funktie en impakt van spinnen en loopkevers in akkers, graasweiden en hun randzones: implikaties voor biologische bestrijding en natuurbehoud. Rapport van het project 01160188 OZF RUG, 4 pp + 11 bijlagen.
|
Distinctive mutational patterns, termed ‘mutational signatures,’ are associated with different mutational mechanisms (Alexandrov et al. 2013). There are more than 100 somatic mutational signatures defined across various cancers, of which some have been attributed to endogenous mutagenic processes (Phillips 2018). Most germline mutations can be accounted for by two signatures, SBS1 and SBS5. Both signatures are ubiquitous among normal and cancer cells (Moore et al. 2021). The mutational signatures identified in our patient exhibited known single base substitution signatures (SBS1, SBS5), including one associated with HR-based DNA damage repair error (SBS3), consistent with RAD51C role in HR-mediated repair of ICL and double-strand DNA breaks (Somyajit et al. 2012; Vaz et al. 2010). In Kaplanis et al., the two individuals with postzygotic mutational factors shared a large contribution from SBS1 (Kaplanis et al. 2022).
|
Data handling, statistical analyses, and graphical representation were performed in R, version 4.0.3 (packages tidyverse, naniar, tableone and ggplot2) (36, 37) and in MS Excel. Distribution of A→G mutation and viral load of patient samples was visualized with function ggplot, method “loess.” Causal diagram analysis was performed with directed acyclic graph using tool for creating, editing, and analyzing causal diagrams [DAGitty, version 3.0 (38)].
|
Estudos realizados entre 2002 e 2006, os quais envolveram 90.000 pacientes em 81 países, demonstraram um aumento da prevalência estimada de tuberculose resistente (DR-TB, do inglês drug-resistant tuberculosis).( 4 , 5 ) Em 2005, ocorreram 500.000 casos novos de TBMR no mundo, correspondendo a 5% do número total de casos de tuberculose. No mesmo ano, a prevalência de TBMR primária foi de 2,9% (variação, 2,2-3,6%), enquanto a de TBMR adquirida foi de 15,3% (variação, 9,6-21,1%), respectivamente.( 4 )
|
The difficulty in extracting totally intact mRNA from brush oral cytology is thought to be due to the high level of ribonuclease in saliva present during cell collection, storage, and processing, which results in differences in levels of specific mRNAs [17, 18]. Another important contribution to the RNA quality may be the dead and dying cells that make up the squamous epithelium. In fact a case could be made that brush cytology samples of any squamous epithelium, such as skin, cervix, or oral and pharyngeal tissue, are going to include partially degraded RNA. Despite this, RNA from brush cytology has shown changes in gene expression supported by work from different laboratories when RT-PCR is used with suitable mRNA controls and consistent primer design [15, 16, 19, 20].
|
Nos patients ont tous été pris en charge dans les 72 heures suivant le diagnostic. Durant les 24 heures après le diagnostic de SIADPO, 64,4% des patients ont été réopérés. Tous nos patients ont bénéficié d'une préparation pré-opératoire par un remplissage vasculaire à base de sérum physiologique dont la quantité variait en fonction du poids et de la diurèse; l'objectif étant d'obtenir une diurèse d'au moins 75ml/heure. Des flacons de macromolécules ont été perfusés aux patients présentant un état de choc, soit dans 22,2% des cas. Une transfusion de sang total a été effectuée chez 19 patients (42,2%). Du plasma frais congelé a été administré chez 2 patients (4,4%).
|
Первичный гиперпаратиреоз (ПГПТ) — это повышение секреторной активности околощитовидных желез (ОЩЖ) вследствие их опухолевого или гиперпластического изменения. При этом на сегодняшний день ПГПТ во всем мире рассматривается как третья эндокринная эпидемия, наравне с сахарным диабетом и другими заболеваниями щитовидной железы . Стоит отметить, что истинная распространенность этого заболевания претерпела изменения после внедрения лабораторно-диагностического алгоритма, включающего обязательное исследование общего и ионизированного кальция в стандартном биохимическом анализе крови. Ввиду отсутствия эффективной альтернативы лечению ПГПТ хирургический способ по-прежнему остается единственным верным тактическим решением ведения больных с установленным диагнозом ПГПТ . Эффективность хирургического лечения составляет 95–98% при частоте возможных послеоперационных осложнений до 1–2% при условии высокой квалификации и опыта хирурга . В связи со сложностью топической диагностики для выполнения адекватной паратиреоидэктомии, как правило, выполняется ревизия всех ОЩЖ с последующим удалением одной или нескольких пораженных желез [6–8]. Однако двусторонняя ревизия шеи ввиду травматичности приводит к таким возможным осложнениям, как травматизация возвратных гортанных нервов и сосудов шеи, проявляющаяся парезом и кровотечением соответственно.
|
Ein generisches Problem, das sich insbesondere im Kontext von Peptidvakzinen stellt, ist die Frage nach der richtigen Auswahl von geeigneten Zielantigenen für eine effektive T‑Zellantwort. Prinzipiell ist es möglich, nur ein einzelnes Antigen für einen Impfstoff auszuwählen, allerdings sprechen triftige Gründe dagegen. Beispielsweise erscheint der Einsatz von multiplen Antigenen schon deshalb sinnvoll, weil neben HLA-Klasse-I- auch HLA-Klasse-II-restringierte Peptide enthalten sein sollten, die eine CD4+-T-Zellantwort induzieren können und die für die Entwicklung einer produktiven Immunantwort wesentlich sind. Zudem können kurze Peptide, so wie sie auf HLA-Klasse-I-Molekülen natürlich vorkommen, verwendet werden, aber auch verlängerte Peptide können zum Einsatz kommen, von denen man annimmt, dass sie nach entsprechender Prozessierung zu spezifischen Immunantworten führen. Ein weiterer relevanter Vorteil von synthetischen Peptiden, im Vergleich zu verschiedenen anderen therapeutischen Ansätzen ist, dass Aminosäuresequenzen einen sehr genau definierbaren Wirkstoff darstellen, der grundsätzlich kurzfristig und nach spezifischen Vorgaben herstellbar ist. Andererseits wird dadurch natürlich auch das Spektrum möglicher Immunantworten begrenzt, was wiederum die Auswahl der Zielantigene sehr zentral macht. Ein wesentlicher Aspekt dabei ist die Einschränkung, dass für die Auswahl von HLA-Klasse-I-Liganden der jeweilige persönliche HLA-Genotyp eine wesentliche Rolle spielt. Dies kann durch die individuelle Analyse von Zielstrukturen, beispielsweise durch eine massenspektrometrische Analyse von HLA-gebundenen Peptiden [29, 30], oder aber durch Stratifizierung der Patienten entsprechend ihres HLA-Allotyps adressiert werden. Vakzinierungsstudien mit solchen synthetischen Peptiden in verlängerter Form zeigten bei Frühformen des Vulvakarzinoms eine klinische Wirksamkeit. Allerdings muss hier als Einschränkung beachtet werden, dass in diesem Fall die durch die Impfung induzierte T‑Zellimmunität primär gegen das ursächliche humane Papillomvirus 16 (HPV 16) und nicht gegen die zellulären Tumorantigene gerichtet war .
|
Los datos necesarios para la validez de los procedimientos se basaron en el programa SERAP de la SER, realizado en 34 áreas de salud con el objetivo de detectar precozmente la artritis de inicio y establecer unidades de artritis de inicio (derivación+diagnóstico+tratamiento) . El programa incluía instrucciones y materiales de derivación, un algoritmo diagnóstico y recomendaciones de tratamiento basadas en la evidencia y se caracterizaba por una gran flexibilidad. En SERAP se observó que los factores asociados a la mayor eficiencia de las unidades eran la retroalimentación a primaria, incluida la negativa y que los tiempos de espera a reumatología general fueran cortos .
|
Usually, the main ingredients in compound feed (hereinafter: feed) preparation are cereals . The prevalence of mycotoxins in crops could be up to 60–80%, and it is supposed to be higher in the grains used for feed preparation than in food crops . The infestation of crops by mycotoxigenic fungi can occur in the field, during cultivation, or during storage and processing. Inadequate agricultural and crop management practices, inadequate drying of raw materials, poor packaging, storage, and/or transport conditions, favor the growth of fungi, thus increasing the likelihood of mycotoxin contamination .
|
Where C shows the concentration index for health outcome (i.e., poor-HRQoL), x¯k is the mean of explanatory variable xk, Ck is the C for xk, defined analogously to the C and βkx¯kμ is the elasticity of poor-HRQoL with respect to the explanatory variable xk. The ∑kβkx¯kμCk indicates the contribution of explanatory factor xk to the C. A negative (positive) contribution of an explanatory factor to the C demonstrates that the wealth-related distribution of the factor and the association between the relevant factor and poor-HRQoL contributes to a lower likelihood of poor-HRQoL among the poor (rich). The last term, GCεμ, is the residuals component and reflects the socioeconomic-related inequality in health outcome that cannot be explained by systematic variation in xk across wealth groups25.
|
Статистическую обработку полученных данных вы- полняли с использованием пакета программ STATISTICA (ver. 8.0; StatSoft, Inc., 2001). Проверка нормальности рас- пределения количественных признаков была проведена с использованием критерия Шапиро-Уилка (Shapiro-Wilk’s W-test). Поскольку выборки исследованных параметров поведения удовлетворяли гипотезе о нормальном рас- пределении, были использованы методы параметрической статистики: однофакторный дисперсионный анализ (ANOVA) с фактором «группа» (контроль, агрессивные самцы, жертвы); последующее попарное сравнение по- казателей осуществляли с помощью LSD-теста Фишера.
|
En México, los resultados de la Encuesta Nacional de Epidemiología Psiquiátrica (ENEP) señalan que los tres trastornos mentales más frecuentes padecidos alguna vez en la vida fueron los de ansiedad (14,3%) seguidos por los trastornos asociados con el abuso de sustancias (9,2%) y los del estado de ánimo (9,1%) (5). Al desagregar estos datos por sexo, los tres trastornos principales en las mujeres fueron las fobias (específicas y sociales) y el episodio depresivo mayor (5). Por otra parte, datos del Programa Nacional de Salud (2007–2012) indican que la depresión unipolar es una de las principales enfermedades responsables de AVISA en las mujeres. De acuerdo con lo anterior, las mujeres son más propensas a padecer estos trastornos y síntomas de depresión y ansiedad (6–7).
|
As autoridades sanitárias nos diferentes países passaram, então, a recomendar a adoção de outras estratégias para conter a transmissão do vírus, tais como: a proibição de aglomerações, restrição à circulação e limitação do contato com populações especiais (por exemplo, em instituições de longa permanência, como é o caso de prisões). Tais medidas geraram impactos negativos sociais, econômicos e relacionados à saúde10.
|
Mutations of BTN3A1 in human cancers. (A) The mutation frequencies of BTN3A1 in different cancers in cBioportal database. CNA, copy number alteration. (B) The mutation types of BTN3A1 in cancers. (C) Nucleotide substitutions of BTN3A1 in cancers. (D) The number of mutations and the affected amino acids of BTN3A1 in cancers. (E) The frequency of driver mutations in patients of BTN3A1 altered and unaltered groups (*P < 0.05).
|
The pIMBB258 plasmid used is a derivate of pZ52, in which all 4 cysteine codons had been substituted with serine codons and the codons for the first five amino acids of SecA from E. coli had been deleted and replaced by a hexa-histidine tag21. Therefore, we re-introduced the first codons using a QuickChange protocol according to the manufacturer's description. Also using site-directed mutagenesis, two codons were changed to code for cysteines, resulting in proteins with two cysteines, either in position 329 and 704 or 329 and 472 and an N-terminal hexa-histidine tag after translation. The SecA mutants were expressed in BL21 (DE3) cells in LB medium containing 100 µg mL−1 ampicillin at 37 °C to mid-log phase and induced with 0.5 mM IPTG for 2 h. Cells were then resuspended in 50 mM Tris-HCl pH 8, 50 mM KCl, 5 mM MgCl2, 2 mM dithiothreitol (DTT) pH 8, and purified by nickel affinity chromatography (Ni-NTA, Qiagen, Hilden, Germany), followed by size exclusion chromatography on Superdex 200 (16/60; GE Health Care) that removed DTT. SecA fractions (0.2 mg mL−1) in 50 mM Tris-HCl pH 8, 50 mM KCl, 5 mM MgCl2 were subjected to labelling with fluorescent dyes via maleimide chemistry, with a stochastic process occurring during derivatization with equimolar ratios of the dye molecules. A fivefold excess of a solution containing equimolar concentrations of the fluorescent FRET-pair dyes Atto520 (donor) and Atto647N (acceptor) were added and incubated at room temperature for 60 min. Subsequently, the protein was separated from unbound dye via size exclusion chromatography. Due to the stochastic labelling, the protein solution contained equimolar ratios of both dyes, with a total degree of labelling of approximately 0.2.
|
The area under the curve of the power spectra in the gamma range was calculated over the 2 s stimulus period and then the log of this value was taken to provide a measure of gamma power. Analysis of the increase in gamma (30–100 Hz) power during each of the stimulation intensities, using a one-way repeated measures ANOVA of gamma power × stimulation intensity, confirmed a general dependence of gamma amplitude on stimulation intensity [F(11) = 6.07, p = 0.002]. Time-frequency spectrograms (Figure 2) demonstrated a clear increase in the >30 Hz gamma power range during stimulation, in the high sensation, low pain and high pain intensities, which was not apparent in low sensation. The gamma power increase appeared to follow the periodicity of the stimulation train at 7 Hz, consistent with the observation of a 7 Hz increase in the spectrogram. In addition, decreases were observed in the mu (~10 Hz) and beta (15–30 Hz) frequency ranges, consistent with effects observed in previous stimulation studies (Cheyne et al., 2003; Gaetz and Cheyne, 2006; Ploner et al., 2006). Analysis of the mean gamma power (30–100 Hz) confirms an increase with stimulus intensity (Figure 3). Furthermore, analysis performed in order to explore phase-locking revealed that the gamma oscillations seen in this study were evoked.
|
Pacientes com DAP classificados como Rutherford Grau I e Categoria 1 a 3 foram avaliados no Centro de Pesquisa Clínica do Centro de Ciências da Saúde da Universidade de Oklahoma. Os pacientes chegaram em jejum, mas foram autorizados a tomar seus medicamentos habituais. Todos foram recrutados por encaminhamento das clínicas vasculares do Centro de Ciências da Saúde, bem como por anúncios em jornais para possível inscrição em um estudo ligado a exercícios físicos.14,15 No entanto, os pacientes foram incluídos no estudo se estivessem totalmente dentro dos seguintes critérios: (a) teste ergométrico em esteira com limitações devido a sintomas de claudicação intermitente e (b) índice tornozelo-braquial (ITB) ≥ 0,90 em repouso ou ITB ≥ 0,73 após o exercício.1
|
（1）一线治疗：Svoboda等曾探索BV-R-CHP（BV+利妥昔单抗+环磷酰胺+阿霉素+泼尼松）方案一线治疗CD30阳性B细胞淋巴瘤的疗效和安全性。这项单臂Ⅰ/Ⅱ期研究安全性分析共纳入31例患者，研究结果显示ORR为100％，其中86％患者获得CR。值得注意的是，研究中5例DLBCL患者均取得较理想的疗效，截至文章发表，均未发生疾病进展。另有一项随机对照Ⅱ期研究试图比较R-CHOP与BV-R-CHP方案一线治疗DLBCL的疗效及安全性，但随着DLBCL一线治疗格局的变化，研究于2017年暂停。因此，BV联合方案一线治疗DLBCL的临床证据有待更多数据支持。
|
After Ku55933 treatment, the levels of H3.1K9ac decreased continually until 24 h after UV radiation ( Figures 2A, C ). At the same time, the acetylation of H3.1K14 showed a decrease after radiation and the lowest level appeared at approximately 4 h after radiation. Then, the H3.1K14ac levels were restored and remained steady until 24 h ( Figures 2A, C ). Combined with Ku55933 and UV radiation treatment, levels of H3.1K27ac and H3.1K56ac were also decreased, while the patterns of H3.1K27ac and H3.1K56ac were the same as those in radiation samples from treated cells, which are shown in Figures 1B, D . The H3.1K27ac level has bottomed out at approximately 4 h after radiation and then remained steady at this level for 24 h. The lowest H3.1K56ac also appeared at approximately 4 h after UV irradiation and then the acetylation levels started rising and returned to normal levels at approximately 16 h after radiation and continued to rise slowly for 24 h ( Figures 2A, C ).
|
MM and GH conceived the study and supervised its design and coordination. The design of the study was set up by HdV and MB. HdV, MB, HB and GH were involved in experimental work. Microarray analysis was performed by HdV, PdG and GH. HdV drafted the manuscript and GH and MM participated in its preparation. All authors have read and approved the final manuscript.
|
Practice nurses and healthcare assistants will be trained for around 45 min to deliver standardised sessions that will include two principal discussion points. First, participants will be provided with the results of their blood tests and will be informed about the different types of blood cholesterol and its importance for CVD risk. They will highlight that diet is an important modifiable risk factor that can potentially help them decrease their CVD risk by lowering LDL cholesterol. The second point of discussion will focus on the major sources of SFA in the diet for the population at large, including dairy, meat and cakes/biscuits. Participants will be given the opportunity to ask any questions with regards to the information provided, and the HP will finish the session by emphasising that the proposed changes can achieve results in a short time period.
|
Op T3 en T4 werden dezelfde vragenlijsten gebruikt, waarbij op T3 veelal de meer algemeen geldende situaties en op T4 de periode van de eerste lockdown (gedefinieerd als: ‘de periode van half maart 2020 tot half juni 2020 toen scholen gesloten waren en er alleen online onderwijs was vanwege het coronavirus’) werden uitgevraagd. De vragenlijst richtte zich op de volgende domeinen: eet- en drinkgedrag (suikerhoudende non-alcoholische dranken, gezonde en ongezonde snacks), leefstijl (roken, alcohol, fysieke activiteit), sociaal-emotionele gezondheid (eenzaamheid, relatietevredenheid ouders en beste vriend(in), geluk). De vraagstelling en codering wordt beschreven in de aanvullende digitale content Supplement Methode.
|
Table 1 shows detection limits of LAMP and PCR assays detecting DNA of meningitis pathogens and using spiked CSF specimens. The pneumococcus LAMP method could detect as few as 10 copies of both purified DNA and spiked CSF specimens within 30 min with greater sensitivity than conventional PCR (11). The sensitivity of the LAMP method was comparable to that of real-time PCR targeting lytA (31). Hib LAMP also detects 10 copies of purified DNA in a 60-min reaction, reflecting a detection limit with a more than 100-fold greater sensitivity than both PCR for the detection of bexA and nested PCR for the detection of Hib (9). The meningococcus LAMP assay was more sensitive than the previously described PCR method. The detection limit of the LAMP assay was measured down to around 10 copies per reaction with a greater sensitivity than that of conventional PCR (10, 12). Using the DNA spike CSF specimens as a template, the detection limit of meningococcal PCR detection method was attenuated while that of LAMP method unchanged.
|
virale Vektoren, die ein Antigen von Mtb exprimieren. Als Vektoren dienen replikationsunfähige Influenzaviren, modifizierte Vaccinia-Ankara-Viren (MVA) und humane oder Schimpansenadenoviren. Hierzu zählen TB-FLU-04L, MVA85A, Ad5Ag85A und ChAdOx.185A (Tab. 1 und Tab. 2; [28–32]).
|
First I explored the steady-state levels of SodA at intermediate Fe-Fur levels in the absence of superoxide stress. Simulations showed that SodA mRNA levels were kept in a relatively narrow range as Fe-Fur levels were changed from 2 to 2000 nM (Figure 2). Unlike typical regulatory systems which regulate transitions between a high and a low expression state, i.e. turn a gene on or off, this FFL regulates transitions between similar expression states. Although the SodA mRNA has similar concentrations in these states, it has substantially higher turnover (higher production and degradation rates) at low iron levels (Figure 2, dotted line).
|
Sucrose, myo-inositol and sinigrin were obtained from Sigma Chemical Co. (purity > 99.5%). For electrophysiological tests, sucrose was presented in a series of concentrations from 0.001 to 10 mM dissolved in 2 mM KCl, an appropriate electrolyte for the electrophysiology of Helicoverpa caterpillars2777. As a control for the specificity of effects of diets on the sensitivity of the sucrose-best neuron, we also tested whether diets containing different contents of sucrose have effects on the sensitivity of another phagostimulant neuron and a deterrent neuron, i.e. the independent phagostimulant neuron to myo-inositol and the deterrent neuron to sinigrin in the medial sensillum of H. armigera caterpillars37. Concentration of both chemicals was 1 mM, a concentration often used in lepidopteran taste studies6478.
|
We first clustered the genes of S. taccada, S. hainanensis, and nine other angiosperm species (Helianthus annuus, Lactuca sativa, Daucus carota, Arctium lappa, Erigeron canadensis, Coffea canephora, Arabidopsis thaliana, Eutrema salsugineum, and Nelumbo nucifera) into homologous gene groups, with 31,225 groups identified. Among these gene groups, 8266 were shared by all species and 658 were single-copy orthologous groups. In order to date the divergence between S. taccada and S. hainanensis, the 658 single-copy genes were used for phylogenetic tree construction. With the constructed phylogeny, we estimated that S. taccada and S. hainanensis diverged ~11 million years ago (Figure 2d).
|
At this point already, these microRNAs (and miR-371a-3p in particular) seem to check most of the requirements for a reliable liquid biopsy marker . Nevertheless, two important studies (one in serum and one in plasma), having the strength of being multicentric in nature, were even more determinant to confirm the true application of this marker in the clinical setting. First, the prospective study by Dieckmann and collaborators, including 616 TGCT patients and 258 male controls, disclosed a diagnostic sensitivity, specificity and area under the curve of 90.1%, 94.0% and 0.966, respectively, for miR-371a-3p. Its accuracy clearly surpasses the combined sensitivity of classical serum markers across histologies (seminomas and non-seminomas) and clinical stages (I to III) . Additionally, Nappi and co-workers disclosed 100% specificity and 96% sensitivity for confirming active germ cell malignancy in 111 patients with history of GCT . These large studies were decisive for prompting miR-371a-3p forward and towards implementation in real-life clinical context . Finally, interesting work by Lembeck and collaborators indicate that miR-371a-3p could solve the issue reported above related to non-specific elevations of AFP due to liver cytotoxicity from chemotherapy agents, since miR-371a-3p remained undetectable in this scenario .
|
Mice were sacrificed by cervical dislocation, and the hind-leg muscles were carefully excised, fixed in 1% paraformaldehyde (PFA) for 30 min at room temperature (RT), dehydrated in a sucrose gradient, and frozen in liquid nitrogen. A cryostat (Leica CM 1850, Leica Microsystems GmbH, Wetzlar, Germany) was used to obtain 10-μm muscle sections, and the sections were processed for immunofluorescence, following the protocol described by Straka et al. (2018). Primary antibodies used in this study are listed in Supplementary Table S1.
|
The histopathological aspects of the alveolar damage described for the six patient biopsies in this study are in line with the results already published for the patients by Barisione and colleagues . The main observation was DAD, to various severity, with an accumulation of material and exudate in the remaining extracellular space, an enrichment of macrophages, neutrophilic granulocytes, and collagen. These results coincide with data from many other studies and reveal a considerable similarity with histopathological data from other cases showing ARDS [6, 8, 25]. Few and still limited ultrastructural investigations on the ultrastructural changes of the lung in COVID-19 patients have been published so far (e.g., [7, 26]). These studies underline the similarity between lung damage induced by COVID-19 and other cases of ARDS. The data of our more extended analysis reveal a striking similarity with detailed ultrastructural data presented for ARDS in other diseases [24, 27]. Alveolar damage seems to start with the detachment of alveolar epithelial cells. The endothelial cells appear intact in regions where the alveolar epithelial cells have started to detach and reveal intracellular changes, such as vacuolization, in regions of more severe alveolar epithelium damage. The structural integrity of the capillary endothelium at early stages of ARDS was also described for other cases of ARDS [24, 27] and in animal models which suggests that the endothelial damage follows the damage of the alveolar epithelium and is not the cause for the latter. However, we cannot rule out the presence of molecular changes, e.g., in the cell contacts providing the barrier function of the endothelium, which were not directly visible at the ultrastructural level.
|
Desta forma, nota-se que a avaliação do tecido pulmonar e do VD após o IAM é um diferencial do trabalho, bem como a caracterização do efeito antioxidante do PS nesses tecidos, abrindo caminhos para melhor entendimento das ações de compostos antioxidantes nas alterações pós infarto e o uso do PS em diferentes tempos de intervenção e em outros modelos.
|
Ainda, dirigir por mais de quatro horas ininterruptas também permaneceu como preditor do uso de anfetaminas, porém, com diferença marginalmente significante (p = 0,073). Somado ao achado descrito acima, essas informações apontam para a necessidade de observância dos pressupostos da Lei 12.619/2012, a Lei do Descanso. b Essa lei assegura ao motorista intervalo mínimo de uma hora para refeição, além de intervalo de repouso diário de 11 horas, o que sugere um período de trabalho diário de até 12 horas. Logo, os motoristas que dirigem por mais de 12 horas diárias, além de estarem em desacordo com a lei, estão mais predispostos a usar anfetaminas. Esse dado é consistente com o estudo de Williamson 22 que mostrou que motoristas de caminhão que usam estimulantes desobedecem as leis de trânsito, especialmente aquelas relacionadas às horas de trabalho. A periculosidade dessa infração é observada pelo fato de que motoristas que dirigem mais de 12 horas diárias estão mais propensos à fadiga e aos seus desdobramentos. 2 Assim, van der Beek 2 propôs que a redução do número de horas trabalhadas seja uma das estratégias de proteção à segurança e saúde dos motoristas de caminhão, aumentando as chances de sua adequada recuperação após um dia típico de trabalho e, por outro lado, reduzindo a chance de seu envolvimento em acidentes de trânsito.
|
As observed in other C4 species, most genes encoding for proteins involved in C4 photosynthesis were significantly upregulated in the C4 species B. prostrata (C4) when compared with Sed. sedoides (C2) and T. diffusa (C3) (Table 1, Supplementary Dataset S2–S4). Out of 18 C4-related transcripts, 16 and 13 transcripts encoding known C4 cycle proteins were significantly upregulated (p < 0.001) in B. prostrata (C4) compared with T. diffusa (C3) and Sed. sedoides (C2), respectively. ALANINE AMINOTRANSFERASE (AlaAT, Log2FC = 5.17) was the most abundant followed by PYRUVATE ORTHOPHOSPHATE DIKINASE (PPdK, Log2FC = 4.63), PHOSPHOENOLPYRUVATE CARBOXYLASE (PEPC, Log2FC =4.12), BILE ACID:SODIUM SYMPORTER FAMILY PROTEIN 2 (BASS2, Log2FC = 3.97), NADP-malic enzyme (NADP-ME Log2FC = 3.86), PEP/phosphate translocator (PPT, Log2FC = 3.61) in B. prostrata (C4) as compared with T. diffusa (C3). Conversely, BASS2 Log2FC = 3.51, PPdK Log2FC = 3.37, PHOSPHATE TRANSPORTER 1 (PHT1, Log2FC = 3.16), PEPC (Log2FC = 2.95), and AlaAT (Log2FC = 2.61) were in the top five of highly upregulated genes in B. prostrata (C4) when compared with Sed. sedoides (C2). However, not all C4-related geneswere significantly upregulated in B. prostrata (C4) as compared with Sed. sedoides (C2). TRIOSE PHOSPHATE TRANSLOCATORransporters [TPT (Bv8_194450_rkme.t1), a chloroplast dicarboxylate transporter isoform [DIT (Bv4_072630_xjai.t1)] and a CARBONIC ANHYDRASE isoform [CA (Bv8_194450_rkme.t1)] were significantly upregulated in Sed. sedoides (C2) when compared with B. prostrata (C4) (Supplementary Dataset S2). Interesting, PHT1 (Bv3_049110_qgnh.t1) was significantly upregulated in T. diffusa (C3) as compared with Sed. sedoides (C2) (Supplementary Dataset S2).
|
La metodología en esta investigación fue de tipo cualitativa. Esta metodología permite interpretar las diferentes miradas, lecturas y símbolos de la realidad, aproximándose de esta forma a los diferentes contextos y marcos conceptuales, haciendo posible la organización, sistematización e interpretación de las políticas públicas (19,20).
|
Schulung in Blutzucker-Selbstmessung. Dokumentation der Glukose-Profile: mindestens 4 Messungen täglich (nüchtern, 1 h postprandial). Bei Beginn einer Insulintherapie sollte die Patientin über die Symptome und Risiko von Hypoglykämien, sowie über das richtige Verhalten in dieser Situation geschult werden. Eine schlechte Adhärenz zu regelmäßigen selbstständigen Blutzuckermessungen steht mit einem erhöhten Präeklampsierisiko in Zusammenhang und war in einer Studie mit Zugehörigkeit zu niedriger sozialer Klasse, nichteuropäischer Herkunft und Diabetes in der Familienanamnese assoziiert . Hingegen konnten bei guter Adhärenz mit guter Blutzuckereinstellung keine Unterschiede zwischen täglich 4 Messungen und Messungen jeden zweiten Tag in mütterlichen und kindlichen Outcomes festgestellt werden . Eine Reduktion der Blutzuckermessungen (Messung alle 2 Tage) kann bei guter Blutzuckereinstellung und fortgeschrittener Schwangerschaft überlegt werden. Sollte eine kontinuierliche Glukosemessung erfolgen sind folgende Blutzuckerwerte anzustreben: Zielbereich 63–140 mg/dl, Zeit im Zielbereich (Time in Range) > 70 %, Zeit unter Zielbereich < 4 %, Zeit über Zielbereich < 25 %
|
Altogether 155 malignant mesenchymal tumours were analysed for MED12 exon 2 mutations. Three mutations were observed, two in early-onset uterine leiomyosarcomas, and one in a metastasis of a uterine leiomyosarcoma (3/41; 7% of uterine leiomyosarcomas studied). This finding is in line with the results of a recent study by Pérot et al (2012), where MED12 mutations were reported in 2/10 (20%) uterine leiomyosarcomas and 1/9 (11%) smooth muscle tumour of uncertain malignant potential, respectively. Highly aggressive and malignant uterine leiomyosarcomas are not generally considered to develop from benign leiomyomas. The observed MED12 mutations are probably not the driving force behind the malignant transformation, but rather indicate that these tumours have developed from leiomyoma precursors. Indeed, it has also previously been suggested that a small subgroup of leiomyomas may actually develop into malignancy (Christacos et al, 2006). Would this be the case, identification of molecular markers that could be used in detecting such leiomyomas would be of high clinical significance as in most cases the leiomyosarcoma diagnosis is only made at surgery and many patients present with an advanced disease. In this study, no mutations were found in other sarcomas or in gastrointestinal stromal tumours. Overall, the low frequency of MED12 exon 2 mutations in various mesenchymal tumours suggests that the high mutation frequency observed in uterine leiomyomas is not a common feature for all mesenchymal tumours.
|
When glomerulation, petechia, or mucosal fissure developed after bladder deflation, it was graded from none (0) to severe (4). Bladder biopsies were taken at four sites about 2 cm lateral and posterior to the ureteral orifice immediately after hydrodistention. The purpose of the bladder biopsy was to exclude the possibility of carcinoma in situ. A 14-Fr urethral Foley catheter was indwelled for one day after injection and an oral antibiotic was prescribed for seven days upon discharge. Patients were monitored in the outpatient clinic two weeks later and had a follow-up every three months. During each visit, a three-day voiding diary, symptom scores, pain VAS, and global response assessment (GRA) were reassessed. The largest voided volume in the three-day voiding diary was considered the measure of functional bladder capacity (FBC).
|
Des bibliothécaires sympathiques et compétents de l’Université de Calgary nous ont aidés à construire la plateforme d’une publication en ligne. Ils nous ont guidés tout au long de nos démarches pour faire enregistrer une URL et nous ont offert des fonds de départ en puisant dans une subvention aux publications. Le DrDonnon, à titre de corédacteur, moi-même à titre de rédacteur et l’un de nos auxiliaires à l’enseignement à titre de directeur de rédaction, avons lancé la revue. On a annoncé la publication d’une nouvelle revue, lancé un appel à communications, reçu et envoyé des manuscrits pour examen, pris des décisions éditoriales et publié le premier numéro de la revue. La production des numéros suivants a été très exigeante puisque nous n’étions que trois à faire tout le travail. Malgré les formidables défis que représente le démarrage d’une nouvelle revue, on a construit la base, obtenu plus d’aide, persisté et nous y sommes arrivés.
|
MuS is a chronic neurological disease characterized by inflammatory, autoimmune, demyelinating, and neurodegenerative events . It affects the CNS, and although it is typically presented as episodes of clinical deterioration followed by periods of remission (relapsing-remitting), most patients with MuS will present irreversible neurological disabilities over time . The diagnosis of MuS diagnosis relies on a combination of characteristics seen via neuroimaging studies such as magnetic resonance imaging (MRI), CSF sampling, and nonspecific clinical symptoms . Given that these findings are not specific to MuS—especially in the initial stages of the disease—the diagnosis is usually delayed and often confused with other neuroinflammatory disorders. Nevertheless, evidence has suggested that early diagnosis—and, consequently, early therapeutic intervention—may attenuate the disease symptoms and further progression by decreasing the harmful effects of chronic inflammation in the CNS .
|
O aneurisma verdadeiro da artéria dorsal do pé é incomum e sua fisiopatologia segue ainda obscura 5 , 8 . Para Aragão et al. 1 , somente 24 casos foram relatados até o momento na literatura. Porém, a maioria dos aneurismas envolvendo artérias infrapoplíteas comumente é de origem traumática 2 , 9 . Afastar antecedentes de traumas ou procedimentos no membro inferior é importante, uma vez que, na maior parte dos casos de aneurisma descritos na artéria dorsal do pé, tratava-se de pseudoaneurimas e não de aneurismas verdadeiros 1 , 5 , 6 .
|
Ook gaven enkele deelnemers aan dat het door de maatregelen en adviezen om de verspreiding van het COVID-19-virus tegen te gaan, lastiger was geworden om goed op aanbiedingen te letten (bijvoorbeeld omdat er minder frequent boodschappen werden gedaan of nog maar één supermarkt werd bezocht) en dat door het ‘hamsteren’ in de supermarkten soms juist de goedkopere producten niet meer te verkrijgen waren, zoals hieronder geïllustreerd:‘Sinds de corona-uitbraak zijn a: de boodschappen weer veel duurder geworden. Waardoor het moeilijker rondkomen is. En dankzij de periodes waarin mensen massaal gingen hamsteren hebben wij wel eens zonder boodschappen gezeten. Omdat de normaal wat goedkopere producten gewoon uitverkocht waren. We moesten dan vaak de duurdere of andere producten halen, waar we het budget dus niet voor hebben.’
|
The argument that total population risk might increase and therefore we should not inform people about THR - though arithmetically absurd and based on the unethical premise that it is acceptable to mislead people - has proven to be a remarkably persistent rationalization for anti-THR activists. It is so often repeated that the original debunking of it, an article that basically just graphs the y = (1-x)/x function and expands on the point from the previous paragraph , has been cited by scores of journal articles about THR (including most of the substantive overview articles on the topic) and hundreds of presentations and popular communications, presumably because the later authors believed it was necessary to respond to the claim that the article debunks. But there has not previously been a good quantitative response to the next layer of rationalization: Even though social risk will clearly be lower if THR is widely adopted, somewhere out there is a hapless smoker who would have soon won his struggle to give up nicotine to avoid all further health cost, but he becomes doomed to failure when presented with the information that he could use a low-risk alternative, resulting in a net health cost.
|
La restauration fonctionnelle pourrait être considérée comme un acte de renaissance, de restauration narcissique et de remaniement identitaire. En effet, nous pensons que la prise en charge chirurgicale, impliquant l’acte et la relation avec le chirurgien, participe à l’amélioration psychique du suicidant, en permettant sa reconstruction mentale.
|
In den letzten drei Jahrzehnten hat sich ein Organisations- und Arbeitsmodell durchgesetzt, das von den privaten und öffentlichen Akteuren in der Produktion, in den Dienstleistungen und in der Verwaltung zum Leitbild erkoren wurde. Es avancierte zu einem generellen Muster für die Gestaltung von Organisationen. Die Innovation diffundierte jedoch weltweit erst durch eine weitere, nämlich technische. Beide Neuerungen zusammen beschleunigen den Wandel, der vor allem durch stete technologische Fortschritte immer schneller wird. Das Modell firmiert unter dem Namen lean production bzw. lean administration. Es intendiert, eine möglichst schlanke, von allem vermeintlich überflüssigen Ballast bereinigte Organisation zu etablieren, wobei die Informationstechnologie, vornehmlich in Gestalt des Internets als Fundament für die globale Reichweite und die ständige Temposteigerung gilt. Diese zum Ideal stilisierte Organisation ist durch die Corona-Pandemie in eine Krise gestürzt. Sie wird vermutlich überleben, sofern tiefgreifende Korrekturen erfolgen. Zu erinnern ist daran, dass dieses System angesichts augenfälliger Dysfunktionen in den letzten Jahren bereits verändert wurde.
|
En la franja b, se observó una gran dispersión de las concentraciones alrededor de los 25 µg/m3 en la zona occidental, abarcando por completo las localidades de Bosa, Fontibón, Kennedy, Puente Aranda y, parcialmente, a Engativá, Antonio Nariño, Rafael Uribe Uribe, Tunjuelito y Ciudad Bolívar (figura 4). El resto de la ciudad se ubicó en el objetivo intermedio 3 y tan solo la parte norte de la unidad de planeación zonal de Usaquén y la parte sur de la unidad de planeación zonal de Los Cedros (localidad de Usaquén), así como la unidad de planeación zonal Lourdes (localidad de Santa Fe) y parte de las unidades de planeación zonal de Sosiego, 20 de Julio y San Blas (localidad de San Cristóbal) cumplieron con las guías, lo que indica que las concentraciones aumentaron en la parte oriental de la ciudad comparada con la franja a, en la cual se cumplió con los valores de las guías.
|
During the first 3 months after the operation, the patient experienced hepatic failure, AKI, disseminated intravascular coagulation (DIC), and pneumonia. Hemodialysis was performed three times per week. The patient was bedridden for the entire day, and his ECOG PS was 3–4. The enteral tube was placed in the jejunum to administer medicine and nutrition; however, enteral nutrition was stopped repeatedly owing to the worsening of postoperative complications or gastrointestinal symptoms. Consequently, he received both parenteral and enteral nutrition with a total energy of 1200 kcal/day and 25.0 g/day protein. Physical findings and serum levels related to renal function are shown in Table 1. When his body composition was analyzed using the InBody® (Inbody S20; Biospace, Seoul, Korea) system, the skeletal muscle mass, skeletal muscle mass index (SMI), fat mass, body fat, and extracellular water (ECW) to total body water (TBW) ratio were 14.2 kg, 5.85 kg/m2, 19.4 kg, 39.0%, and 0.436, respectively. The patient had edema, ascites, and a pleural effusion. His dry weight estimated by subtracting the excess fluid from the actual body weight was 47.0 kg; the patient lost 10.0 kg in about 5 months. He met the diagnostic criteria for sarcopenia by the Asian Working Group for Sarcopenia (AWGS) and was classified as severely malnourished. He underwent repeated cycles of constipation and diarrhea. Table 1Physical findings and serum levels related to renal functionLevelDay −126day1day112day200Height (cm)155155155155Weight (kg)57.149.847.855.9Body mass index (kg/m2)23.820.719.923.3Serum creatinine (mg/dL)0.802.361.060.77eGFR creatinine (mL/min)72.622.253.375.4Serum cystatin C (mg/dL)0.953.472.942.81eGFR cystatin (mL/min)74.113.918.019.1Day −126: first day of hospitalizationDay 1: first day of nutritional intervention
|
PD-L1 expression was examined in human bone marrow stromal cells (NKTert and HS5) either when they were cultured alone or co-cultured with NKTCL cells (SNK-6 and NKYS). qRT-PCR and western blot revealed remarkably elevated levels of PD-L1 mRNA and protein in stromal cells, respectively, when co-cultured with NKTCL cells (Figures 1A–D). Consistently, flow cytometric and immunofluorescent analysis showed higher levels PD-L1 expression on bone marrow stromal cells, respectively, after co-culturing with NKTCL cells (Figures 2, 3).
|
The PERMANOVA indicated a significant effect of species (R2 = 0.86, p = 0.001), Year (R2 = 0.06, p = 0.001), and interaction between year and species (R2 = 0.02, p = 0.001) on δ13C and δ15N values. Colony type was not significant in this analysis (R2 = 0.003, p = 0.06), and neither was the interaction between species and the colony type.
|
No entanto, estudos randomizados de grande impacto não mostraram diferença a favor da CRM sem CEC no que diz respeito à morbimortalidade.19 - 21 Em nossa análise, com uma amostra atual e multicêntrica, a única diferença encontrada a favor da CRM sem CEC foi o menor número de reoperações por sangramento. Isso também foi verificado no estudo de Lamy et al.,22 onde mesmo não existindo uma diferença significativa na morbimortalidade, houve uma diminuição na taxa de reoperação por sangramento. A taxa de reoperação por sangramento encontrada em nosso estudo é similar à encontrada em outro estudo,23 mas, em contrapartida, a mortalidade foi 4,5 vezes maior nos pacientes que tiveram essa complicação.
|
Se construyó una base de datos con los resultados obtenidos y se hizo el análisis estadístico descriptivo correspondiente. Con el programa Stata 12, se hizo un ANOVA de una vía para determinar diferencias entre las excreciones y secreciones nativas, y las mayores y menores de 10 kDa de C. vicina y S. magellanica, seguido de la prueba post hoc de Bonferroni para establecer cuál de las variables estudiadas aportaba dicha diferencia.
|
Looking at the individual anthocyanins, Dp-glu and its derivatives (Dp-ac-glu and Dp-pc-glu) increased over time whereas Cy-glu and its derivatives remained constant. The non-significant changes of Dp-pc-glu/Dp-glu and Cy-pc-glu/Cy-glu might be the consequence of coumarylated glucosides being produced at the same rate of non-acylated glucosides. However, a different rate of consumption of the two molecules can not be ruled out and it would lead to the same result: coumaroyl-glucoside derivatives may be more reactive and preferential substrate for the formation of derived pigments. A higher reactivity has been indeed previously reported in a fermentation study, where the rate of synthesis of p-coumaroyl-vitisins resulted higher than that of non-acylated vitisins.34
|
In the last decade, researchers are addressing the identification and determination of lignan profiles in main food groups and in food chain products; when a new dataset for nutritional values is used, it is very important to evaluate the quality of the analytical information . New experimental and analytical data on lignan content are now available for updating and expanding food composition databases . In Table 1 the main national databases of lignans are described.
|
The degree of T cell clonal expansion can be estimated with these diversity indices, which are used to characterise the relative distributions of multiple TCR clones (Table 1) . Diversity scores have been used to characterise immune reconstitution of T cells following transplantation under different conditions, e.g., different procedural choices or different graft sources of HSCs, but also in the context of viral infections or GvHD. Studies reporting TCR diversity in GvHD patients are summarised in Table 2.Table 1Important definitions associated with TCR diversity indices.Important definitions for TCR diversity analysis∙ Gini coefficient: inequality of a system or frequency distribution of different TCRs with values ranging between 0 (maximum diversity with perfect equality) to 1 (maximum unevenness)∙ Shannon entropy & diversity index: a measure of the randomness within the system, takes into account both species richness and evenness, rises with increase in number of TCRs and evenness of their abundance with 0 representing no diversity. There is no upper limit to the value of Shannon diversity index∙ Simpson’s diversity index, Ds: measures the probability that sequences randomly selected from a sample will belong to different T cell clonotype (0 = system with no diversity, 1 = system with high diversity)∙ Inverse Simpson’s diversity index, 1/(1-Ds): is inverse of Simpson’s Diversity index (1 = system with no diversity, increasing value = increase in the diversity)Table 2TCR sequencing studies analysing GvHD tissue biopsy samples and peripheral blood samples.Author, Journal, YearStudy DesignMentioned GvHD prophylaxisSamples & Timepoints (n = Number of patients for sequencing)Measurement of DiversityKeypointsMeyer et al., Blood. 2013 Comparison on basis of response to steroidsCSA/MMF/MTX/TacPB—time of aGvHD diagnosis and 25–35 days after; GI biopsy - time of aGvHD diagnosis (n = 15)Gini coefficientBetween the steroid-sensitive and steroid-refractory GvHD patients, there was no difference in TCR diversity in either blood samples or biopsiesLongitudinal tracking of TCR clones identified in the GI tract in blood at the time of diagnosis and 30 days after indicated clonal expansion in patients with steroid-refractory GvHD when compared with patients with steroid-sensitive GvHD.Samples from patients with severe steroid-refractory GvHD had more consistent TRB clonotype populations in different areas of biopsies than those from patients with steroid-sensitive GvHD.van Heijst et al., Nature Medicine. 2013 Comparison of TCR diversity in patients with graft source, GvHD status, steroid therapy and infection (CMV/EBV)T cell depleted graft or CSA/MMF/TacPB (CD4 and CD8 T cells)—either 6 months or 1 year post-SCT (n = 28, 18 aGvHD patients)Inverse Simpson’s diversity indexPatients with aGVHD (grade 2 or 3) are associated with higher TCR diversity than patients without aGvHD and with mild grade 1 aGvHDYew et al., Bone Marrow Transplantation. 2015 Comparison of TCR diversity between type of transplant and GvH responseT cell depleted graft or haplo transplantPB - before SCT and different time points post (GvHD patients - closest to the date of aGvHD diagnosis) (n = 21, 11 aGvHD patients)Inverse Simpson’s diversity indexSignificantly stronger enrichment of the ten most abundant TRB clones in GvHD patients than in non-GvHD patients; very modest difference in TRA with GvHD statusKanakry et al., JCI Insight. 2016 Retrospective analysis of 8 aGvHD patients by obtaining skin and/or GI tract biopsiesPTCy or CNI/MTXPB - different timepoints; Skin biopsies - different timepoints; GI biopsies - time of aGvHD diagnosis (n = 8)-With few exceptions, dominant clones in blood were infrequently observed in GI tract biopsy samples and almost not at all in skin biopsy samples.Gkazi et al., Front Immunol. 2018 Assessment of TCR repertoire in cord blood transplant paediatric patients (median age = 2 years and 1 month)Not mentionedPB - different timepoints (n = 16, 14 GvHD patients)Gini coefficientTCR diversity inversely correlated with GvHD scores - GvHD drives clonal expansionLink-Rachner et al., Haematologica. 2019 Comparison between different transplant regimensATG or PTCy, CSA + MTX, Tac + MMFPB (CD8 T cells) - day 60 and day 180 post-SCT (n = 25, 16 aGvHD patients & 12 cGvHD patients)Inverse Simpson’s diversity indexaGvHD—memory CD8—tended towards higher diversity; cGvHD—memory CD8—tended towards lower diversityKoyama et al., Biology of Blood and Marrow Transplantation. 2019 Evaluate TCR repertoire in GvHD tissuesTac + MTXPB - time of aGvHD diagnosis, and before first-line treatment; Biopsies - same as PB (n = 8)-Clonal expansion of TCR repertoires in different organs in GvHD.Limited overlap of the gut and blood repertoire.Organ specificity of TCR repertoires post SCT and in GvHD.Leick et al., Biol Blood Marrow Transplant. 2020 Look at longitudinal changes in reconstitution of T cells during first 3 months post-SCTTac + MTXPB - different timepoints (day 15, day 30, day 50 and day 100 post-SCT) (n = 99, 40 aGVHD patients)Increased clonal expansion precedes aGVHD development (on comparison with donors)Shah et al., Biol Blood Marrow Transplant. 2020 Comparison on basis of response to steroids and mismatchesNot mentionedPB - time of aGvHD diagnosis (n = 146)Shannon entropy, Simpson’s diversity indexNo difference in TCR diversity between steroid responders and nonresponders among aGvHD patientsThe table summarises studies using TCR sequencing to analyse TCR repertoires in GvHD patients. The site and timepoint of the collection of samples are mentioned for each study.GI gastrointestinal, aGvHD acute graft-vs.-host-disease, SCT stem cell transplantation, TCR T cell receptor, TRB T cell receptor beta chain, PTCy post transplantation cyclophosphamide, ATG antithymocyte globulin, Tac tacrolimus, MTX methotrexate, CSA cyclosporine, MMF mycophenolate mofetil, CNI calcineurin inhibitor, PB peripheral blood
|
En la presente investigación, el análisis de la distribución alélica y de los genotipos correspondientes a los polimorfismos Q192R y L55M de la PON1 demostró una ausencia de riesgo por estos factores genéticos para la EVC aterotrombótica, similar a lo encontrado en otras poblaciones, aún con una muestra mayor, para el riesgo de enfermedad coronaria 18 e infarto cerebral 19. Sin embargo, existen aún resultados contradictorios, ya que en un meta- análisis realizado se encontró que hay un pequeño incremento a padecer infarto cerebral en personas que presentan el alelo R del polimorfismo Q192R 20. Posiblemente, aumentando el número de individuos en los grupos control y de casos se realizaría un óptimo análisis de la relación entre los polimorfismos de la PON1 y la EVC en nuestra población.
|
After confirming activation of the mTOR pathway during asthma onset and demonstrating the requirement of mTOR for asthma disease onset, we then further analyzed whether mTOR pathway suppression can rescue the loss of balance between Th17 and Treg and between Th1 and Th2 cytokines in asthmatic mice during disease onset. The levels of serum mTOR and cytokines in mice were measured by ELISA after asthma induction with or without budenoside or mTOR inhibitor treatment. As a result, mTOR in mouse serum was elevated in the asthmatic mice compared to that in the controls, and this increase was reversed by treatment with budenoside or mTOR pathway inhibitors. There were no significant differences between mTOR levels in the intervention groups (Fig. 3c).
|
Dos estudios en un seguimiento a 30 días de pacientes con IAMSEST, encontraron asociación entre el intervalo QTc y eventos cardiovasculares mayores: a mayor intervalo QTc mayor mortalidad cardiovascular 8,9. En uno de estos estudios se encontró que un intervalo QTc > 468 ms predijo eventos cardiovasculares mayores con una sensibilidad de 72% y una especificidad de 61% 9, mientras que, en el otro, el punto de corte fue > 458 ms con una sensibilidad de 76,2% y una especificidad de 88,2% 8.
|
Concomitant pain medications during the 12 weeks of study are summarized in Table 1. No new medication was started during the 12 weeks of study. The patients carried on with the medication administered prior to capsaicin patch treatment because they presumably were on optimal doses.
|
Here we define annotations for the gene expression data, genes, and samples that we will use across this paper in both the existing methods and the proposed method section. Let X ij be the expression values for genes i = 1,2, ..., m and samples j = 1,2, ..., n. We assume that samples are grouped into two groups S1 and S2. In our work, S1 represents cancer samples and S2 represents normal samples.
|
Our data demonstrate that mHTT interaction with PNKP and the resultant decline in PNKP’s enzymatic activity was evident in CTX and STR of HD transgenic mouse models but insignificant in the CRBL. Consistent with these findings, CTX and STR, the most affected brain regions in HD displayed extensive DNA strand breaks with impaired DNA repair capacity. In contrast, PNKP activity and genome integrity was marginally affected in CRBL, the brain region that is reported to be relatively unaffected in HD. However, no alterations in the steady-state levels of PNKP, ATXN3 and other key TCR components were observed between CRBL vs. CTX or STR. Our present data do not explain why mHTT expression specifically impacts PNKP activity and genome integrity in the CTX and STR but spares CRBL. Further investigation is required to understand region-specific decreases in PNKP activity and DNA break accumulation in the HD brain. Complete characterization of the TCR complex in different brain regions may provide valuable insight into the selective neuronal vulnerability to mHTT-mediated toxicity. It will be interesting to understand the mechanism that imparts protection to CRBL against mHTT and could provide another node in the signaling pathway that could potentially be developed as a therapeutic target. Furthermore, more rigorous biophysical and structural studies are necessary with purified peptides/proteins to characterize the true nature of the protein-protein interactions and interacting partners to understand how this putative HTT-RNA polymerase complex maintains neuronal genome integrity and survival.
|
The expression data for the three biological replicates on the three carbon sources were normalized (Additional data file 8 [Tables S3 to S5]) and compared in a pair-wise manner, in order to detect genome-wide transcriptional changes in response to a change in carbon source. Differentially expressed genes for each of the comparisons were identified by applying a significance statistical test (see Materials and methods, below) and considering a significance level (or cutoff in P value) of 0.01. Table 2 shows the total number of significantly regulated genes within the genome of A. nidulans for the three possible pair-wise comparisons between carbon sources, as well as the number of upregulated and downregulated genes. Because the change in carbon source is expected to result in changes in carbon metabolism, the number of differentially expressed genes that were comprised in the metabolic reconstruction for A. nidulans is also presented for each case. It is observed that there is an over-representation of metabolic genes that exhibit significant changes in expression (metabolic genes only comprise about 7% of the total number of genes). The complete list of genes whose expression was significantly changed in the pair-wise comparisons can be found in Additional data file 9 (Tables S6 to S8; they are also partly illustrated in Figures S1 to S3 in Additional data files 1, 2 and 3, respectively). The differentially expressed genes were functionally classified based on Gene Ontology (GO) assignments provided by CADRE (Additional data file 10 [Tables S9 and S10]).
|
Some studies have demonstrated that MSCs are able to promote conversion of the Th1 phenotype into a Th2 response . In this sense, MSCs could contribute to NP, considering the microenvironment already saturated with Th2-dependent interleukins in this setting. In the present study, we did not detect IL-4 which is considered an important interleukin that induces differentiation from Th0 to Th2 immune response in NP-derived cell cultures, regardless of the presence of MSCs. This would suggest that in our coculture experiments with NP-derived cells, MSCs could not intensify a specific Th2 response.
|
(A,B) Galvanostatic cycling of Li/Li2OHCl/Li cell with and without LE optimization at a current density of 0.1 mA cm−2. (C,D) Galvanostatic cycling of LE-optimized Li/Li2OHCl/Li cell at current densities of 0.1 mA cm−2 (100 h), 0.2 mA cm−2 (200 h), and 0.4 mA cm−2 (100 h).
|
Tussen mei en augustus 21 werden 20 NeuroSAFE-patiënten gelijktijdig geëvalueerd middels CLM. De Histolog®-scanner werd gebruikt (SamanTree Medical SA, Lausanne, Zwitserland) om prostaatweefsel te scannen. Na de prostatectomie werden aan de posterolaterale zijde van de prostaat twee kapjes gesneden, na bewerking gescand met de Histolog®-scanner en beoordeeld op beeldkwaliteit door een getrainde pathologielaborant. Vervolgens werden de kapjes in 4-6 lamellen gesneden en ook gescand. De lamellen werden vervolgens geïnkt en verder verwerkt voor NeuroSAFE volgens protocol. De snijvlakken in vriescoupes werden als positief of negatief beoordeeld door een uro-patholoog. De CLM-beelden werden beoordeeld door één getrainde uropatholoog.
|
Mediante el programa SPSS 26 se calculó la adecuación de la muestra con el índice de Káiser-Meyer-Olkin (satisfactorio si es mayor de 0,80), el cual fue de 0,903; la matriz de correlaciones mostró que los ítems estaban fuertemente interrelacionados y conformaban los nueve dominios descritos.
|
Following the ensemble modeling strategy, it is important to understand how the LRM regions affect the system’s predictive performance. In particular, what method should be used for response and what for predictive purposes in the regression setting? To answer this question, we chose to run regression model multiple times according to the rotation of variables serving each role, response vs regressors. This scheme is known as Alternating Regression Model37 and measures how each variable contributes to the predicted response values according to a cross-validation scheme. Since each variable alternates its role at both sides of the equation, the final step involves computing statistics like mean and median values across both the replicated model runs and the predicted profiles. Intuitively, the LRM stability improves by rotating the variables, and we noted that an outlying role is played by Limma. We averaged the final profiles with and without it, but found the best results when Limma is excluded from the final averaging step. Its outlying values are not matched by other methods, meaning that no method contributes to its profile when Limma is used as the response. Instead, its predictive effects are retained (i.e. Limma as regressor) because the ensemble LRM models neutralizes them by assigning non-significance to the corresponding regression coefficients. Finally, gene and ncRNA signatures derived from each of the DE profiles required some control of variability, and we applied thresholding through the boxplots and the IQR measures applied to the estimated LRM coefficients. The stringency of the assigned thresholds affects the size of our final selections.
|
Bezüglich der Operationstechnik wird aktuell zwischen der nichtanatomischen extraartikulären Stabilisierung in der modifizierten Lemaire-Technik mittels Tractusstreifen und der anatomischen Rekonstruktion des anterolateralen Ligamentes mittels autologer Gracilissehne unterschieden. Ein eindeutiger Vorteil einer dieser Techniken konnte bislang nicht beschrieben werden. In ersten Untersuchungen scheint eine Kombination aus VKB-Ersatzbandplastik und anterolateraler Stabilisierung zu einer geringeren Rerupturrate und zu sehr guten, teils der isolierten VKB-Ersatzbandplastik überlegenen klinischen Ergebnissen zu führen [29, 30].
|
Entre as TCs que foram solicitadas para diagnóstico presuntivo de COVID-19, 63,2% tiveram achados incidentais, e a maioria deles consistiram em nódulos pulmonares (15,8%), espessamentos peribrônquicos (13,1%), faixas fibroatelectásicas (11,4%) e atelectasia (9,5%). Entre os achados pulmonares, os nódulos apresentaram significância estatística de p < 0,0001 entre os demais. Nódulos pequenos, acredita-se, não apresentam relevância clínica; no entanto, oito pacientes apresentaram achados de massa pulmonar superior a 3 cm (0,5% da amostra). Isso reforça a hipótese de que a grande maioria dos achados incidentais são irrelevantes; porém, o método também permite detectar lesões assintomáticas que necessitam de melhor gerenciamento11. Assim, embora opacidade em vidro fosco bilateral e consolidação tenham sido relatadas como as características predominantes dos exames de imagem por COVID-19, as manifestações da TC no tórax podem variar em diferentes pacientes e estágios11.
|
Teachers responded to a single item regarding students’ in-class behavioral engagement (i.e., “over this week, what level of engagement has this student shown in your PE class?”). Teachers rated each student on a 7-point scale, anchored at 1 (no engagement), 4 (average engagement), and 7 (very high level of engagement) based on the intensity of their participation (relative to their classmates) within the last week. A single item was used at the request of teachers in order to minimize response burden; similar approaches have been implemented previously for the measurement of behavioral engagement, and have been shown to display evidence of criterion validity (e.g., Ntoumanis, 2005).
|
Según la literatura científica, la exposición a dos o más contaminantes puede causar efectos aditivos o interactivos debido a la sinergia entre estos. En estos casos, se recomienda estimar el cociente de riesgo combinado (combined HQ, CHQ), el cual se calculó para la exposición a glifosato más AMPA, siguiendo las recomendaciones de Miri, et al. 39.
|
Bez względu na rodzaj pobudzonego receptora łuk odruchowy kaszlu obejmuje przewodzenie pobudze-nia włóknami aferentnymi nerwu błędnego przez zwój czuciowy górny do części grzbietowo-przyśrodkowej jądra pasma samotnego (pierwsza synapsa odruchu), a następnie do pnia mózgu. Drogę eferentną tworzą włókna ruchowe nerwu błędnego (nerwy krtaniowe) i nerwów rdzeniowych (nerwy międzyżebrowe i nerw przeponowy). Łuk odruchowy kończy się skurczem efektorów – mięśni międzyżebrowych, mięśnia przepony i mięśni krtani [4, 12, 14] (rycina 1). Klinicznie pierwszą przygotowawczą fazą odruchu jest głęboki wdech z towarzyszącym zwiększeniem ciśnienia w jamie brzusznej wskutek skurczu i obniżenia przepony. Następnie dochodzi do gwałtownego wydechu przy zamkniętej głośni, co wiąże się ze wzrostem ciśnienia w klatce piersiowej. Na szczycie wysokiego ciśnienia następuje otwarcie głośni, uniesienie podniebienia miękkiego oraz skurcz mięśni brzucha, co powoduje uniesienie do góry przepony i wyrzut powietrza pod dużym ciśnieniem przez górne drogi oddechowe [4, 12].
|
Outros estudos26 , 27 sugerem avaliações mais prolongadas, de até 10 minutos, uma vez que muitos participantes desenvolveram HO tardiamente. Em nosso estudo, com média de idade mais baixa (52,1 ± 9,1 anos), alguns participantes também desenvolveram queda pressórica mais tardia, visto que a prevalência aos 3 minutos foi maior que aos 2, e que a de 5 minutos foi maior que ambas.
|
Mice submitted or not to AMF exposure were perfused with 4% paraformaldehyde 1 day or 7 days post-treatment. After extraction of the brains, the tissues were frozen and subsequently cut in 12 μm-thick slices using a cryostat. Iron was detected using an iron stain kit (Sigma) in accordance with the manufacturer’s instructions.
|
A pressão do líquido cefalorraquidiano eleva-se imediatamente após o clampeamento aórtico e após a isquemia medular. Juntamente à diminuição da pressão de perfusão medular, esse mecanismo pode ser uma das principais causas de isquemia medular. A pressão do líquido cefalorraquidiano pode ser facilmente monitorizada, e a drenagem do liquor com o intuito de reduzir sua pressão a níveis abaixo de 10 cmH2O é amplamente praticada. Uma revisão da literatura confirmou a eficácia da drenagem do líquido cefalorraquidiano na prevenção e no tratamento da isquemia medular após o tratamento do aneurisma torácico e do AATA12. A drenagem do líquido cefalorraquidiano pode ser realizada com segurança com o uso do LiquoGuard® (Möller Medical GmbH, Fulda, Alemanha), um novo dispositivo para drenagem liquórica controlada e contínua, projetado para manter a pressão do líquido cefalorraquidiano próxima aos valores desejados. Isso evita a drenagem desnecessária e permite a monitorização simultânea da pressão liquórica e sua drenagem ativa13.
|
The “Endo-symbiotic Theory of Mitochondrial Evolution” suggests that mitochondria originally evolved from engulfed aerobic bacteria, over millions of years of adaptation [68, 69]. As such, antibiotics target mitochondria, and therefore this side effect could be exploited to target the increased mitochondrial mass within CSCs. Interestingly, several FDA-approved drugs/antibiotics that target mitochondria have already been shown to eradicate CSC activity, such as OXPHOS inhibitors (metformin and pyrvinium pamoate) [70–73], a potassium ionophore (salinomycin) [74, 75] and known inhibitors of mitochondrial biogenesis and mitochondrial translation (the erythromycins, the tetracyclines and the glycylcyclines) [76, 77]. In fact, doxycycline and azithromycin have already shown significant efficacy in treatment-resistant cancer patients, with MALT lymphoma and non-small cell lung tumors, respectively [78–80].
|
Nasilenie lęku u matek sprawdzono Inwentarzem stanu i cechy lęku (STAI), autorstwa Spielbergera, Gorsucha i Lushene’a, w polskiej adaptacji Spielbergera, Strelaua, Tysarczyk i Wrześniewskiego . Kwestionariusz złożony jest z 20 pytań, składających się na dwie skale: X-1, która służy do badania lęku-stanu oraz X-2, do badania lęku-cechy .
|
In the next step, MgsR stability was analyzed in both, a ΔmcsB deletion as well as a kinase inactive mcsBC167S mutant (Kirstein et al., 2005) that resulted in a significant increase of MgsR half-life (Figure 2). The higher basal level of MgsR already indicates that arg-P could be an important trigger for protein degradation. Interestingly, the sole inactivation of the McsB kinase function in the mcsBC167S mutant also resulted in an extended MgsR half-life (12.3 min) compared to the wild type, but was also slightly shortened in comparison to the ΔmcsB deletion mutant (17.7 min). These results indicate that (i) the McsB kinase activity plays an important role for MgsR destabilization but also that (ii) the McsB protein itself is needed for proper MgsR degradation. The difference in half-life extension observed in both mutant strains prompted us to speculate that kinase activity and adaptor protein function of McsB are two distinguishable modes of operation.
|
Резкое изменение спектральных характеристик растений на границе видимой красной и ближней инфракрас- ной частей спектра в диапазоне 690…740 нм (положение «красных краев») имеет большое значение для диагностики стрессовых воздействий. Подобную особенность отмечали A. Lowe с коллегами (2017). Она может быть объяснена тем, что хлорофилл сильно поглощает длины волн вплоть до 700 нм, и, следовательно, растительный материал в этом диапазоне имеет низкую отражательную способность, которая резко возрастает в ближней инфракрасной области спектра (~720 нм). Обнаружено, что различия в спектрах можно описать за счет изменения ряда известных индексов, в частности TVI и MCARI, связанных с содержанием хлорофилла.
|
Similarly, the values of HRV indicators of the subjects during the S2 experiment were also significantly higher than those at baseline, indicating that the sympathetic activation induced by the children’s perceived risk caused a substantial change in EDA and HRV (Table 5, Figure 5). Girls had a higher relative change than boys. Specifically, the analysis of the relative change of IBI, SDNN, RMSSD, LF, HF and LF/HF from the baseline to the S2 experiment was performed after grouping the 41 subjects by gender. According to the analysis, the relative changes in all seven physiological indicators for HRV were lower in boys than in girls. Among them, IBI, SDNN, RMSSD, LF and HF increased from the baseline to the S2 experiment, but boys had lower scores than girls, and the relative change was positive. LF/HF showed a downward trend from the baseline period to the S2 experiment, the relative change was negative, and boys had higher scores on these two indicators than girls did. In summary, the amplitude of variation of HRV indicators was lower in boys than in girls, indicating that girls are more sensitive than boys to alarm sound signals.
|
A síndrome DRESS foi descrita pela primeira vez por Bocquet et. al. em 1996, em pacientes com sintomas constitucionais, linfadenopatia e eosinofilia periférica. É considerada uma reação idiossincrática importante e de hipersensibilidade a medicamentos, com extensas características clínicas. Sua incidência é desconhecida, mas ocorre com maior frequência em adultos.3,4 Vários medicamentos estiveram associados à DRESS, mas a vancomicina é um dos mais frequentes.3,5 A DRESS tem um amplo espectro de condições clínicas, desde sintomas leves até falência de múltiplos órgãos. No entanto, o tempo de exposição ao medicamento, a suscetibilidade individual e o diagnóstico imediato podem influenciar a resposta do paciente. As taxas de mortalidade variam de 3 a 10% e o diagnóstico imediato e a retirada do medicamento são importantes para obter um resultado favorável.3,4
|
Im Folgenden werden wir nach einigen allgemeinen Ausführungen zum Verhältnis von Erzählen und Argumentieren in der Social-Media-Interaktion (Kap. 2) anhand eines Korpus von Social-Media-Daten zu politischen Reden (Kap. 3) induktiv herausarbeiten, wie sich alltägliches Erzählen und Argumentieren in Social-Media-Kommentaren zu politischen Reden verbindet. Dabei wird sich zeigen, dass Erzählen neben dem sprachlichen Ausdruck von Alltagserlebnissen auch zur Stützung von Argumenten und zur Positionierung im kommunikativen Gefüge der beteiligten Akteure dient (Kap. 4). Um die Rolle zu beleuchten, die das fragmentarische Erzählen für das Argumentieren in der interaktiven Nachbearbeitung von politischen Reden auf Social-Media-Plattformen hat, fragen wir danach, welche Anschlussstellen für erzählendes Argumentieren es in den Reden gibt, wie sich Miniatur-Erzählungen in den jeweiligen kommunikativen Konstellationen und medialen Umgebungen der untersuchten Textgattungen jeweils ausprägen und welche spezifischen argumentativen Funktionen sie erfüllen. Schließlich fassen wir die wichtigsten Beobachtungen zusammen und formulieren einen Ausblick (Kap. 5).
|
A left atrial endocardial EAM was obtained using the HD Grid, via a patent foramen ovale, with the catheter’s soft, closed shape permitting gentle reconstruction of the LAA endocardial anatomy. The LAA EAM was then refined via an optical fiber, contact-sensing, open-irrigated ablation catheter (TactiCath SE, Sensor Enabled; Abbott), which was constantly monitored via transesophageal echocardiography visualization.
|
In the research of noninvasive blood glucose detection using spectral technology, China started late and fell far behind the developed countries, but in recent years, some initial research has been gradually carried out. Inspired by the dual-wavelength noninvasive oximeter, Xi et al. from Shanghai University of Traditional Chinese Medicine theoretically deduced the use of a limited number of near-infrared wavelengths to detect blood glucose concentration and established a mathematical model. Shen et al. from Beijing Medical University used Fourier near infrared spectrophotometer to conduct a noninvasive test of blood glucose. Li et al. from China Medical University have done some studies on glucose concentration in bovine blood by using near infrared spectroscopy. Chen , president of the Chinese Academy of Sciences, proposed a method of combining near-infrared spectroscopy with differential blood volume spectroscopy. Although this method has great difficulty in implementation, its breakthrough in principle is of great significance. Zhang et al. combined with domestic and foreign research experience carried out some research work on the pressure between the light source probe and the measured part in noninvasive blood glucose detection and studied the application of the genetic algorithm and neural network algorithm in near-infrared noninvasive blood glucose detection.
|
Toutes les fiches proposées étaient construites selon un modèle identique afin de favoriser leur utilisation. Le recto, destiné à la classe, aux élèves, supportant essentiellement un ou plusieurs documents iconographiques (photo, dessin, reproduction d’affiches, texte). Le verso, destiné à l’enseignant et aux parents, présente la trame de l’exploitation pédagogique du document iconographique. En fonction de l’intention pédagogique, chaque fiche pouvait être téléchargée indépendamment. Ces ressources sont complétées par des vidéos de personnels de la santé et de l’éducation qui proposent aux enseignants et aux familles des éléments sur leur utilisation.
|
We then assessed whether the observed result was linked to differences in gene constraint. First, we looked for correlation between the LCV score and the missense o/e score in both the GTEx (all tissues and all genes) and EyeGEx (retinal tissue and genes implicated in inherited retinal disorders only) datasets; we found no significant correlation (Supplementary File 2). Second, we assessed the difference in various constraint metrics between IP/VE-associated genes and all other IED-implicated genes; the findings suggested that the coding constraint is unlikely to be a significant confounding factor (Supplementary File 2).
|
Os resultados mostraram que más condições ocupacionais de motoristas profissionais de caminhão interferem sobre o uso de anfetaminas, após o controle do efeito de características demográficas, de saúde mental e do uso de outras drogas. Embora não seja possível especular sobre a relação causal da associação aqui encontrada, o estudo aponta para a importância de as autoridades competentes atentarem para a organização da atividade ocupacional desses profissionais e, sobretudo, a respeito da fiscalização das leis que a disciplinam, de forma a prevenir o uso de anfetaminas, seus efeitos sobre a direção e possíveis desdobramentos negativos no trânsito.
|
The main inclusions occurred in July and September 2004 and March 2005, which correspond to the peaks of infection and were linked to positive IgM-HEV serology. In Bangui, the rainy season starts in May and finishes in December, and a recrudescence of cases of acute hepatitis E is observed during that period in tropical countries, due to overflowing drains and short-circuiting of networks of clean water and structures for purifying wastewater. The level of endemicity results in high IgG anti-HEV seroprevalences. As there is generally a single source of contamination, generally from water, epidemics of hepatitis E are characterized by spectacular numbers of infected people . The lack of samples during August was probably related to the absence of health professionals, who take their annual vacation at this time. The outbreak may therefore have peaked during August, and the peak observed in September might be only the downward part of the curve of infection. The period between October 2004 and February 2005 represents the inter-epidemic season. Asymptomatic excretion of HEV particles in the stools and the environmental reservoir of the HEV may explain the background noise observed and circulation of the virus.
|
Tous les prestataires des soins (100%) connaissaient que les préservatifs et l’abstinence sont des pratiques pivot pour la prévention et 50 (58,8%) prestataires n’avaient jamais prescrit la prophylaxie post exposition alors que 35 (41,2%) prestataires avaient déjà prescrit la prophylaxie post exposition (Tableau 3).
|
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.