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255M
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153,435,390 |
{
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"DOI": "10.1108/FS-01-2015-0005",
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|
Purpose – The aim of this paper is to test and explore the hypothesis global ruling power, as well as review the six approaches featured in the special edition on global governance/ruling power. Design/methodology/approach – Anthropological and historical records are presented as support for the emergence of ruling power in society; moreover, evidence of global ruling governance/power is reviewed in the six papers featured in the special edition. Findings – Alternatives for global governance are reviewed in two papers, while four papers present evidence in support of the thesis of the emergence of a transnational ruling power/class. Research limitations/implications – Because global ruling power exists informally and surreptitiously, the exact mechanisms of control are difficult to delineate, especially due to the fact that the Powers that Be spend much effort to block research into this area; however, this special edition opens up a promising area for new research efforts into global ruling power and the...
|
2022-12-17T13:57:08.312Z
|
126,010,555 |
{
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"ArXiv": null,
"DOI": "10.1142/S021988781850024X",
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|
We study radical screen transversal (ST)-lightlike submanifolds of an indefinite Kaehler manifold admitting a quarter-symmetric non-metric connection and obtain a necessary and sufficient condition...
|
2022-02-09T16:27:35.187Z
|
249,142,215 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.34190/ictr.15.1.124",
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"license": "CCBYNCND",
"status": "HYBRID",
"url": "https://papers.academic-conferences.org/index.php/ictr/article/download/124/310"
}
|
This paper studies the financial determinants of debt of Portuguese hotel companies using the main indicators suggested by the Trade-Off and the Pecking Order theories. The main objective of this study was to analyse the determinants that most contribute to the debt of Portuguese companies in the hotel industry. The study also aimed to understand the impact of crisis periods on the debt. Since data collected refers to the period between 2005 and 2020 it also analyses the impact of the 2008 financial crisis and, more recently, the global pandemic COVID-19. The results show that debt is negatively associated with profitability and age, and is positively associated with size, growth opportunities and tangibility. These results are in line with the Pecking Order theory, ranking the choice of financing methods. We can also conclude that the way hotels finance their assets will affect their level of debt. We also evidence that debt of Portuguese hotels companies increases in periods of crisis.
Keywords: Debt; Hotels companies; Crisis; Capital Structure
|
2022-07-16T20:31:02.388Z
|
250,688,343 |
{
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"ArXiv": null,
"DOI": "10.1088/1742-6596/49/1/052",
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"license": null,
"status": "GOLD",
"url": "https://doi.org/10.1088/1742-6596/49/1/052"
}
|
The cluster structures of the excited states in 11B are studied by analyzing the isoscalar monopole and quadrupole strengths in the 11B(d, d′) reaction at Ed = 200 MeV. The excitation strengths are compared with the theoretical predictions by the antisymmetrized molecular-dynamics (AMD) calculations. It is found that the large monopole strength for the 3/2−3 state at Ex = 8.56 MeV is well described by the AMD wave function with a dilute 2α + tcluster structure.
|
2022-07-31T09:47:22.499Z
|
216,156,896 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.1386/jsca_00012_1",
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"url": null
}
|
When fiction introduces controversial new perspectives, the novel and its film adaptation can play different roles in a cultural discussion. In the wake of globalization and Generation X, the novel 101 Reykjavík (Helgason [1996] 2002) suggested a sex-obsessed slacker identity that most Icelanders rejected or ignored. A later film adaptation (Kormákur, 2000) cut the sharpest edges off the story’s postmodern critique, lessened the protagonist’s immorality, made the narrative more conventional and offered an ending with communal reunification. The film’s success led Icelanders to revaluate not only the novel’s message but their own identity. 101 Reykjavík became the new truth about young Icelanders in the 1990s. This combination of a disputatious novel and a more conciliatory film adaptation is not uncommon with Nordic fiction. For socially ambitious filmmakers, retelling contentious stories in a form more fit for mass consumption can help them bring audiences and nations from old truths to new.
|
2022-09-03T19:59:29.907Z
|
77,612,131 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1596/978-1-4648-0348-2_CH2",
"MAG": "2463137642",
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"status": null,
"url": null
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|
This chapter presents the burden of global reproductive ill health and, where data permit, regional estimates for selected conditions. Ill health refers to morbid conditions such as infections and injury and to nonmorbid measures of reproductive health that directly contribute to adverse reproductive health outcomes, including unwanted pregnancies and violence against women. The chapter is organized into six subsections: unintended pregnancies, unsafe abortions, non-sexually transmitted reproductive tract infections (RTIs), infertility, violence against women, and female genital mutilation (FGM). Unintended pregnancies lead to unintended births and induced abortions. Unintended births often occur among young women who are emotionally and physiologically not mature, which has effects on the health of the mother, the pregnancy, and its outcome. Induced abortions in countries where the practice is illegal are often provided in unsafe environments and by untrained personnel, which contribute to the high maternal death from abortion complications. Sexually transmitted infections (STIs) of the reproductive tract receive attention in programming and research, but little attention is focused on other infections that affect fertility and increase the risk of transmission of other infections. Violence against women violates their rights, including limiting access to and use of prevention and treatment services in addition to physical injury and death. FGM causes bodily disfigurement and may present immediate surgical complications and long-term risk of poor reproductive outcomes, especially during delivery.
|
2022-09-12T03:59:49.278Z
|
128,985,646 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1126/SCIENCE.1137417",
"MAG": "1596682308",
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},
"license": null,
"status": null,
"url": null
}
|
An integrated monitoring system is proposed for India that will monitor terrestrial, coastal, and oceanic environments.
|
2022-11-16T16:05:35.885Z
|
144,837,662 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/1467271022000035929",
"MAG": "2050928616",
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"license": null,
"status": null,
"url": null
}
|
This article examines the deterioration in relations between two Cambodian opposition parties and the “international community” from whom they sought support during the 1998 Cambodian elections. It is suggested that the manipulation, by influential political actors, of internationally promoted political concepts such as “democracy,” “sovereignty,” and “the people's will” is problematic for mutual understanding between international and local political actors. In Cambodia in 1998, liberal views of the “people's will” as an amoral and neutral construct facilitating the delegation of authority were awkwardly but influentially conflated, by the election campaigning of the two parties, with a view of the “people's will” as a moral imperative to liberate the nation from alleged “traitors.” This caused widespread adherence, among the parties' followers, to views of the 1998 elections that were non-liberal and antidemocratic in a number of respects. When sharp differences in understandings of the political situation emerged between local and international actors, following the electoral defeat of those opposition party leaders, the fragile nature of a purported “partnership” between a self-appointed “international community” and the Cambodian people was exposed.
|
2022-12-12T22:21:30.401Z
|
1,532,233 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4103/1673-5374.219045",
"MAG": "2770970968",
"PubMedCentral": "5745838"
},
"license": "CCBYNCSA",
"status": "GOLD",
"url": "https://doi.org/10.4103/1673-5374.219045"
}
|
Platelet-derived growth factor receptor alpha (PDGFRα) is a marker of oligodendrocyte precursor cells in the central nervous system. NG2 is also considered a marker of oligodendrocyte precursor cells. However, whether there are differences in the distribution and morphology of oligodendrocyte precursor cells labeled by NG2 or PDGFRα in the developing neonatal rat brain remains unclear. In this study, by immunohistochemical staining, NG2 positive (NG2+) cells were ubiquitous in the molecular layer, external pyramidal layer, internal pyramidal layer, and polymorphic layer of the cerebral cortex, and corpus callosum, external capsule, piriform cortex, and medial septal nucleus. NG2+ cells were stellate or fusiform in shape with long processes that were progressively decreased and shortened over the course of brain development. The distribution and morphology of PDGFRα positive (PDGFRα+) cells were coincident with NG2+ cells. The colocalization of NG2 and PDGFRα in the cell bodies and processes of some cells was confirmed by double immunofluorescence labeling. Moreover, cells double-labeled for NG2 and PDGFRα were predominantly in the early postnatal stage of development. The numbers of NG2+/PDGFRα+ cells and PDGFRα+ cells decreased, but the number of NG2+ cells increased from postnatal days 3 to 14 in the developing brain. In addition, amoeboid microglial cells of the corpus callosum, newborn brain macrophages in the normal developing brain, did not express NG2 or PDGFRα, but NG2 expression was detected in amoeboid microglia after hypoxia. The present results suggest that NG2 and PDGFRα are specific markers of oligodendrocyte precursor cells at different stages during early development. Additionally, the NG2 protein is involved in inflammatory and pathological processes of amoeboid microglial cells.
|
2022-12-16T14:19:00.393Z
|
73,411,473 |
{
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"ArXiv": null,
"DOI": "10.1089/hum.2018.178",
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},
"license": null,
"status": "CLOSED",
"url": null
}
|
Seventy-five percent of patients with beta thalassemia (β-thalassemia) do not have human leukocyte antigen-matched siblings and until recently had no access to a curative treatment. Gene therapy is a promising treatment that can be proposed to these patients. This study estimates its cost and efficacy. In a monocentric retrospective study and cost-efficacy analysis, this study compared the two-year outcomes and costs of patients with β-thalassemia treated by gene therapy and hematopoietic stem-cell transplantation (HSCT). Grade III and grade IV complications, hospitalizations, and length of stay were extracted from the hospital discharge data. Costs were estimated from hospital accounting information and national cost studies. A total of seven patients with β-thalassemia treated between 2009 and 2016 were included, of whom four received gene therapy. Patients treated by gene therapy were older and had fewer complications and hospital admissions. Infectious complications were three times more frequent for patients treated with HSCT than for gene therapy. Average costs were €608,086 for patients treated by gene therapy and €215,571 for HSCT. The total cost of the vector was 48% of the total cost of gene therapy. Gene therapy as a curative alternative for patients lacking human leukocyte antigen-matched donors was costlier but resulted in fewer complications than HSCT.
|
2022-12-17T21:09:21.750Z
|
117,914,547 |
{
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"ArXiv": null,
"DOI": "10.14710/MEDSTAT.5.1.27-35",
"MAG": "1547023180",
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"url": null
}
|
Interval estimation of a parameter is one part of statistical inference. One of the methods that used is the Bayes method. A Bayesian method is combine prior distribution and distribution of samples, so that the posterior distribution can be obtained. Interval estimation using a method Bayes called credibel interval estimation. In this thesis, the distribution of the sample is used a two-parameter Weibull distribution scale-shape-version of survival distribution (reliability). Data that used are data that is not censored data type and data type II censored if prior distribution using non-informative which of the produce distribution the resulting posterior distribution is gamma distribution. Parameters of the sample distribution that to find out is a parameter that by the parameter c (shape parameter) known while the parameter b (scale parameter) had unknown.
|
2022-12-23T16:54:15.135Z
|
213,942,119 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.18378/cvads.v9i7.6912",
"MAG": "2999594825",
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},
"license": "CCBY",
"status": "HYBRID",
"url": "https://www.gvaa.com.br/revista/index.php/CVADS/article/download/6912/7021"
}
|
A pimenta-do-reino foi bastante cultivada no município de Serraria-PB, porém com o passar do tempo foi substituída pelas culturas de subsistência. Todavia, encontram-se alguns exemplares da cultura em poucas propriedades, precisando de atividades de multiplicação e divulgação, a fim de garantir a sustentabilidade do cultivo. O objetivo desse trabalho foi avaliar a produção de mudas assexuada de pimenta-do-reino com e sem o nó na estaca, para posterior plantio da piperácea em uma área de mata nativa. O trabalho foi desenvolvido no Sítio Matinha, zona rural do município de Serraria-PB, de maio a agosto de 2017, em uma área em transição agroecológica. Para produção das mudas de pimenta-do-reino foi utilizado o método de reprodução assexuada, com a técnica de estaquia, onde foram feitas 200 estacas de 30 cm a partir das ramas. As estacas da piperácea com o nó foram as que melhor se desenvolveram dentro das condições trabalhadas, validando assim a experiência dos agricultores.
|
2022-01-27T02:15:13.920Z
|
14,968,113 |
{
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"ArXiv": null,
"DOI": "10.1109/ICCKE.2012.6395355",
"MAG": "2018990455",
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},
"license": null,
"status": null,
"url": null
}
|
The four-leg voltage source inverter (VSI) is becoming increasingly popular in power applications due to its superior performance characteristics such as relatively low dc-bus voltage and capability to handle unbalanced or nonlinear load currents. With unbalanced load condition, to balance such a system, a neutral connection is needed to control each phase voltage independently. Average large signal model in ABC coordinates is obtained and state space equation is presented. This paper presents new decoupled control strategy based on state feedback with simple proportional controller thus each phase is controlled independently in order to track references properly. Simulation results with MATLAB/Simulink show acceptable performance in unbalanced load conditions.
|
2022-02-13T02:11:39.828Z
|
146,741,244 |
{
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"ArXiv": null,
"DOI": "10.1080/14330237.2011.10820450",
"MAG": "2225387257",
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},
"license": null,
"status": null,
"url": null
}
|
The article explores the connections between context, masculinity and the fraternal relationship to understand brotherhood in Xhosa culture. The participant was a Xhosa man (32 years old, with tertiary level education). Data were collected using a semi-structured interview. The data suggest that the fraternal bond is constructed as a complex interplay of sometimes contradictory stances including those that reinforce authoritarian and hierarchical brothering practices. Counternarratives highlight the potential for intimacy and equality in these male-male relationships.
|
2022-08-24T21:42:25.131Z
|
242,264,476 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.21203/rs.2.9522/v1",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBY",
"status": "GREEN",
"url": "https://bmcophthalmol.biomedcentral.com/track/pdf/10.1186/s12886-020-01407-y"
}
|
Background: Data on the retinal vessel morphology in the north China are still scarce so far. The study aimed to evaluate retinal vascular abnormalities and their associations with self-reported diagnosis of cardiovascular and cerebrovascsular diseases in a rural adult population of northeast China.
Methods: A population-based, cross-sectional study was conducted, using the cluster random sampling method. two 40° non-mydriatic retinal photographs of one eye from each participant was taken using a fundus camera. The main Outcome measures: the prevalence of focal and general arteriolar narrowing, arteriovenous nicking, arteriolar sheathing, and retinopathy. Clinical data including general parameters and system diseases were collected by physical and laboratory examination and standard questionnaires.The association between retinal vascular abnormalities and cardiovascular and cerebrovascsular diseases and their risk factors was determined using logistic regressions.
Results: Among 6 267 participants with an age ≥50 years, photographs were obtained of 99.2%, with quality sufficient to perform retinal evaluations in 82.5% (from 5172 participants). Among them, 432 subjects had diabetes. The average age was 61.25±7.37 years. The prevalence of focal arteriolar narrowing, arteriovenous nicking, arteriolar sheathing, retinopathy and general arteriolar narrowing were 9.1%, 8.9 %, 5.0 %, 6.6 % and 6.2% respectively. All the retinal lesions were associated with hypertension (all P<0.01). No significant associations were found between the subjects with or without the presence of diabetes mellitus (P >0.05). After adjusting for age, gender and left/right eyes, hypertension, hyperlipidemia, diabetes mellitus, habits of past or current smoking and alcohol drinking, arteriovenous nicking was strongly associated with the self-reported histories of coronary heart diseases (OR, 1.44; 95% CI, 1.09, 1.89) and retinopathy was significantly associated with self-reported histories of stroke (OR, 2.05; 95% CI, 1.18, 3.57).
Conclusions: Retinopathy is associated with self-reported diagnosis stroke while arteriovenous nicking is associated with the self-reported diagnosis of coronary heart diseases, but the rest retinal lesions are not consistently related to the self-reported diagnosis of coronary heart diseases. Thus, an examination of retinal microvascular characteristics may offer clues to the cardiovascular and cerebrovascsular diseases and could be a potentially novel risk marker.
|
2022-12-15T15:19:19.758Z
|
94,074,221 |
{
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"ACL": null,
"ArXiv": "1504.01345",
"DOI": "10.1002/pip.2735",
"MAG": "1577246871",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "http://arxiv.org/pdf/1504.01345"
}
|
Development of alternative thin film photovoltaic technologies is an important research topic because of the potential of low‐cost, high‐efficiency solar cells to produce terawatt levels of clean power. However, this development of unexplored yet promising absorbers can be hindered by complications that arise during solar cell fabrication. Here, a high‐throughput combinatorial method is applied to accelerate development of photovoltaic devices, in this case, using the novel CuSbS2 absorber via a newly developed three‐stage self‐regulated growth process to control absorber purity and orientation. Photovoltaic performance of the absorber, using the typical substrate CuInxGa1 − xSe2 (CIGS) device architecture, is explored as a function of absorber quality and thickness using a variety of back contacts. This study yields CuSbS2 device prototypes with ~1% conversion efficiency, suggesting that the optimal CuSbS2 device fabrication parameters and contact selection criteria are quite different than for CIGS, despite the similarity of these two absorbers. The CuSbS2 device efficiency is at present limited by low short‐circuit current because of bulk recombination related to defects, and a small open‐circuit voltage because of a theoretically predicted cliff‐type conduction band offset between CuSbS2 and CdS. Overall, these results illustrate both the potential and limits of combinatorial methods to accelerate the development of thin film photovoltaic devices using novel absorbers. Copyright © 2016 John Wiley & Sons, Ltd.
|
2022-12-19T05:13:49.553Z
|
143,544,017 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.1177/1066480799072010",
"MAG": "2003247369",
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},
"license": null,
"status": null,
"url": null
}
|
Planned suicide is a topic that receives much attention in both the popular press and the scholarly literature, and it is not unlikely that family counselors will have clients who ask for assistance as they deal with this topic. In this article, the author provides a case scenario followed by a discussion of pertinent legal and ethical issues.
|
2022-12-20T12:57:53.919Z
|
36,358,956 |
{
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"ArXiv": null,
"DOI": "10.3844/AMJNSP.2012.17.24",
"MAG": "2116852887",
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},
"license": null,
"status": null,
"url": null
}
|
Problem statement: At present, the novel agent that is effective, che ap and easy to approach for treating male sexual dysfunction is re quired due to the current poor therapeutic efficacy . Though Moringa oleifera is reputed for aphrodisiac activity in traditional folklore, no scientific evidence is available. Therefore, we aimed to deter mine the effect of M.oleifera leaves extract on male sexual behaviors in animal model of sexual dysfunct ion. Moreover, the possible underlying mechanisms were also investigated. Approach: Male Wistar rats, weighing 200-250 g, had been ora lly given M.oleifera leaves extract at doses of 10, 50 and 250 mg kg -1 BW once daily at 30 min before the exposure to 12-h immobilization stress for 14 days. They were assessed male sexual behaviors including mounting, intromission and ejaculation nu mbers and latencies after single administration and every 7 days until the end of experiment. To furthe r investigate the possible mechanisms of action, we also determined serum testosterone level of all rat s at the end of experiment together with the determination of suppression effect of the plant ex tract on MAO B and PDE-5 activities. Results: The results showed that after single administration, ra ts subjected to M.oleifera extract at dose of 10 mg kg -1 BW significantly enhanced mounting number. When the treatment was prolonged to 7 days rats subjected to the low dose of extract showed the enh anced intromission number whereas rats subjected to high dose of extract showed the enhanced mounting number. Our data also showed no significant change in serum testosterone level. However, the ex tract could also suppress MAO B and PDE-5 activities. Taken all together, the extract could e nhance male sexual desire and performance via the suppression of MAO B and PDE-5 activities. Conclusion: M.oleifera can be the potential sexual enhancer particularly for acute and short term appl ication. However, further researches are necessary.
|
2022-12-25T17:25:47.735Z
|
10,246,754 |
{
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"DOI": "10.12973/EURASIA.2017.00711A",
"MAG": "2628016176",
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},
"license": null,
"status": null,
"url": null
}
|
Background:As pupils are largely increased the opportunities to contact digital games, the effect of digital games has been broadly discussed and studied. Digital games no longer play the function of entertainment, but could assist students in more active learning and deeper and broader learning, when being applied to instruction. It is limited to learn in classes that combining courses with situated digital games presents the immersive feeling.Material and methods:This study therefore intends to discuss the effect of digital game-based instruction on students’ learning motivation and achievement.Three universities in Taiwan, which are listed on top universities in Taiwan province, are selected as the research subjects in this study. With experimental research, total 326 students of two classes each from the three universities are preceded the experimental teaching for 3 hours per week for 16 weeks (total 48 hours)Results:The research results are summarized as below. 1. Game-based instruction would affect learning motivation. 2. Game-based instruction would influence learning achievement. 3. Learning motivation presents significantly positive effects on learning effect in learning achievement. 4. Learning motivation shows remarkably positive effects on learning harvest in learning achievement.Conclusions:Aiming at the research results, it is expected to propose suggestions for education studies and talent cultivation.
|
2022-12-28T18:09:09.986Z
|
1,016,121 |
{
"externalids": {
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"DOI": "10.1111/j.1467-8519.2009.01725.x",
"MAG": "2010464743",
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},
"license": null,
"status": null,
"url": null
}
|
There is concern that the use of neuroenhancements to alter character traits undermines consumer's authenticity. But the meaning, scope and value of authenticity remain vague. However, the majority of contemporary autonomy accounts ground individual autonomy on a notion of authenticity. So if neuroenhancements diminish an agent's authenticity, they may undermine his autonomy. This paper clarifies the relation between autonomy, authenticity and possible threats by neuroenhancements. We present six neuroenhancement scenarios and analyse how autonomy accounts evaluate them. Some cases are considered differently by criminal courts; we demonstrate where academic autonomy theories and legal reasoning diverge and ascertain whether courts should reconsider their concept of autonomy. We argue that authenticity is not an appropriate condition for autonomy and that new enhancement technologies pose no unique threats to personal autonomy.
|
2023-01-01T17:54:45.737Z
|
236,185,844 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/CTMCD53128.2021.00066",
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"url": null
}
|
Meteorological disasters are the main factors threatening the security of modern power grid, and transmission lines, as the carrier of power transmission, are more easily restricted by the complex and changeable natural environment. Therefore, a risk assessment model based on entropy weighted grey correlation analysis algorithm is proposed. Firstly, the risk of various meteorological disasters is analyzed, and the quantitative expression model of disaster factors is established; then, the correlation between disaster information and transmission line is extracted by using the improved algorithm of multiple grey correlation analysis with entropy weight. Finally, the risk assessment of line operation is realized based on the risk assessment model. The experimental results show that the application of the risk assessment model improves the power grid risk early warning ability and intelligent monitoring level.
|
2022-01-24T18:18:22.523Z
|
149,218,293 |
{
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"ArXiv": null,
"DOI": "10.2307/20458976",
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"url": null
}
|
PERFORMANCE ARTIST AND SOCIAL ACTIVIST Rhodessa Jones began conducting drama workshops with incarcerated women in the late 1980s. Inspired by the success of her one-woman show based on the lives of four inmates in her class, Big Butt Girls-Hard Headed Women, Jones decided to cre ate an ensemble with the inmates at San Francisco County jail. She used as a model Jean Trounstine's theater workshop inside Framingham, Massa chusetts, Prison for Women.' Never one to think small, Jones envisioned a troupe that would not only write and stage original works, but one that would perform in professional theaters for public audiences. She enlisted the help of Sean Reynolds, a social worker and health educator at the jail, and together they assembled a talented collective of artists and activists to work with the inmates, but it took three years to persuade the Sheriff's Department to allow incarcerated women to participate in a public per formance. In 1992, the group staged its first production, Reality IsJust Outside the Window: The Tragedy of Medea Jackson, to a standing-room-only crowd at the Theatre Artaud in San Francisco. The performance was loosely based on Euripides's Medea, and Jones dubbed their experiment the Medea Project: Theater for Incarcerated Women.2 The decision to use Medea stemmed from the fact that a young woman
|
2022-09-02T00:17:09.382Z
|
206,953,193 |
{
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"DOI": "10.1182/blood-2017-04-742726",
"MAG": "2742865635",
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},
"license": null,
"status": "BRONZE",
"url": "https://ashpublications.org/blood/article-pdf/130/11/1285/1402216/blood742726.pdf"
}
|
The US Food and Drug Administration (FDA) negotiates the evidence necessary for drug approval with pharmaceutical sponsors. The resulting data package submitted in support of approval includes labeling that conveys the benefits and risks of a particular agent. Recent approvals in hematology
|
2022-09-12T03:34:34.328Z
|
42,238,805 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.1515/jbcpp-2015-0073",
"MAG": "2215002952",
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"license": null,
"status": "BRONZE",
"url": "http://www.degruyter.com/downloadpdf/j/jbcpp.2016.27.issue-3/jbcpp-2015-0073/jbcpp-2015-0073.xml"
}
|
Abstract Recently, there has been a rapidly growing interest in the role of cannabinoids in the regulation of skeletal remodeling and bone mass, addressed in basic, translational and clinical research. Since the first publications in 2005, there are more than 1000 publications addressing the skeletal endocannabinoid system. This review focuses on the roles of the endocannabinoid system in skeletal biology via the cannabinoid receptors CB1, CB2 and others. Endocannabinoids play important roles in bone formation, bone resorption and skeletal growth, and are sometimes age, gender, species and strain dependent. Controversies in the literature and potential therapeutic approaches targeting the endocannabinoid system in skeletal disorders are also discussed.
|
2022-11-21T18:58:05.766Z
|
231,680,042 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4085/462-20",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": "GOLD",
"url": "https://meridian.allenpress.com/jat/article-pdf/56/9/1003/2903034/i1062-6050-56-9-1003.pdf"
}
|
CONTEXT
Previous reports suggest high-specialized adolescent athletes may be at a higher risk of injury, worse sleep quality, and lower sport enjoyment than low-specialized athletes. Currently, sport specialization literature is primarily composed of adolescent athletes from a variety of sports. However, it is unknown if the findings on sport specialization from predominantly non-running athletes are generalizable to adolescent long-distance runners.
OBJECTIVE
Compare injury history, running volume, quality of life, sleep habits, and running enjoyment among male and female middle- and high-school long-distance runners from different sport specialization levels.
DESIGN
Cross-sectional.
SETTING
Online survey.
PARTICIPANTS
A total of 102 male (age=15.8±0.9 years) and 157 female (age=15.6±1.4 years) uninjured middle- and high-school athletes who participated in long-distance running activities (completion rate=50.7%).
MAIN OUTCOME MEASURE(S)
Participants were stratified by sex and sport specialization level (low, moderate, high). Group differences in self-reported running-related injuries, EQ-5D-Y quality of life, Pittsburgh Sleep Quality Index sleep quality, sleep duration, running habits, and running enjoyment were assessed.
RESULTS
High-specialized male and female middle- and high-school long-distance runners reported competing more months per year (p<0.001), higher weekly run distance (p<0.001), more runs per week (p<0.001), higher average distance per run (p<0.001), and higher running enjoyment (p<0.001) than low-specialized runners. Males reported higher average weekly run distance (p=0.01), higher average distance per run (p=0.01), and better sleep quality (p=0.01) than females. No differences among sport specialization were found for running-related injuries (p=0.25), quality of life (p=0.07), sleep quality (p=0.19), or sleep duration (p=0.11) among male or female middle- and high-school runners.
CONCLUSIONS
High-specialized male and female middle- and high-school long-distance runners reported higher running volumes and running enjoyment than low-specialized runners. However, high-specialized runners did not report a greater number of running-related injuries, lower quality of life, or lower sleep quality or duration as expected.
|
2022-09-09T05:40:52.166Z
|
218,661,183 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1179/174587009X452404",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Mary Ward, 1585–1645, ed. CHRISTINA KENWORTHY-BROWNE (Catholic Record Society, Record Series, 81. 2008. Boydell Press. £45) comprises a carefully selected and well-edited set of sources for the life of Mary Ward. Born to recusant parents near Ripon, Mary Ward’s childhood was spent in Catholic households, where she developed her sense of vocation. Aged twenty-one, she travelled to Flanders where she joined the Poor Clares but felt called to found a new religious congregation for women, independent, self-governing, mobile, unenclosed and prepared to take part in the apostolic work of the Church. For a time her communities and schools, backed by powerful patrons, flourished, but official mistrust and opposition grew, until in 1631 the Pope suppressed the congregation. After imprisonment and living under the surveillance of the Inquisition, Mary Ward was eventually able to return to Yorkshire where, after experiencing something of the dangers and hardships of the siege of York in 1644, she died in January 1645. The major part of the volume is devoted to the English Vita, or Briefe Relation, by Mary Poyntz (the earliest biography of Mary Ward); in addition there are autobiographical fragments and a few miscellaneous letters. A valuable source, and a credit to the CRS and the editor.
|
2022-01-27T10:36:29.388Z
|
163,592,733 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1163/9789004235496_008",
"MAG": "2485828303",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Through the extensive diaries of Presbyterian minister Oliver Heywood, this book explores the role that individuals played in fashioning their religious communities during the Restoration, as England stumbled from persecution towards a limited toleration of Protestant dissenters.
|
2022-02-08T21:09:39.622Z
|
151,720,202 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1017/S0265052516000236",
"MAG": "2560816357",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Abstract: The ideal theory debate rests on two conflicting claims: that justice is “the first virtue of social systems” (justice first), and that a just society is one in which “everyone accepts and knows that the others accept the same principles of justice” (universal consent). Justice first holds that questions about the meaning of justice — and thus about what an ideally just society would look like — must be settled before we can effectively pursue justice. However, universal consent entails a project of justification that can only take place over time. I propose that we avoid this impasse by treating freedom rather than justice as the “first virtue” of a liberal society. Liberal freedom has two distinct and complementary dimensions, which give rise to two distinct and complementary moral aims: on the one hand, to create the social conditions that make responsible agency possible (republican freedom), and on the other hand to carve out a social space within which the demands of responsible agency are relaxed or absent (market freedom). Striking the appropriate balance between these two dimensions of liberal freedom is irreducibly a matter of judgment. A freedom-centered liberalism therefore requires that we treat justice as the endpoint rather than the starting point of political action, thus severing the link between legitimacy and consent.
|
2022-03-06T11:17:33.426Z
|
220,202,317 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1136/bmj.s3-4.194.805",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://www.bmj.com/content/bmj/s3-4/194/805.full.pdf"
}
|
by numerous pealy fibres concentrically armaged. It had under the microscope an indistinctly fibrous structure, but cetic acid developed quantities of round and elongated nuclei, the latter with their long axes in the same direction. In a word, it was a most typical specimen of a .$rtw tumour. 'The growth in the liver, on the other hand, differed from the two preceding ones, in having the properties, not of a fibrous, but of a bhro-piastic growth. It was about the size of a filbert, cut hard with a section of a uniform dead white, with points of translucency here and there, and devoid of any sanguineous staining. A mass of fibres was seen in the field of the microscope, and after the addition of acetic acid, a niumber of nuclei, some spheroidal, some fusiform and narrow. In the lungs were some irregular deposits resembling exudation-matter, consisting of a great many fibres, mostly of an elastic nature, and what appeared to be a few oat-shaped nuclei. (11) EPITIIELIAL CANCER. (Paget, Schuh.) Epithelial growths agree with the general characters of cancer in three particulars: 1. Their infiltrating character, irrespective and destructive of the natural tissues met with in their progressive evolution. 2. Their tendency to the production of the same disease in the adjacent lymphatic glands. 3. Their tendency to recurrence after surgical operations. Now, if of these three cancerous attributes it could be proved, that the two latter are dependent on, and mere consequences of, the first, a great step would be made in the surgery of the disease. That epithelial cancer of the tongue and lips should so constantly recur after operations, need not surprise us; indeed, any one who has dissected these tumnours, and observed how marked their infiltrating nature is, would feel more surprised if they did not return. If, on the other hand, it can be shown that epithelial cancers of the extremities do not return when amputation is performed early (and before any trace of glandular swelling has nianifested itself) above the next joint, it becomes a quebtion, whether complete removal of the tongue and lips, although an operation of extreme severity, would not be more in accordance with the principles of surgery than any partial operation on those organs ? CAsE. Epithetial Cancer of the Foot; Amputation at the Ankle-Joint; no ret arn of the Disease thwree years after the Operation. Mary B. was 71 years of age when she was admitted into the University College Hospital for a malignant ulceration of the foot. She had hitherto always enjoyed good health: no cancer was to be traced in her parents. Mtany years ago she had a corn about the size of a florin, near the little toe ; this she had been in the habit of soaking and cutting from time to time, when, from its size, it prevented her walking. Last January, in going up stairs, she struck her corn, and felt severe pain in it. From that time forwards it had gradually been getting into its present condition. On the outer side of the auterior half of the left foot was a malignant looking ulcer, which extended an inch and a half back on the dorsum, and three inches into the sole of the foot, and rose about half an inch above the general level of the adjacent sound skin. The surface of the ulcer was very rugged from prominient shreds of concreted discharge; and where this was absent, pale red warty excreseences came into view. The margin of the ulcers was thick and rounded. The skin around had a slight bluish, but felt natural. With the exception of the little toe (which was involved in the ulceration in its posterior half), the toes of the foot were sound. The discharge had a fetid smell; she compared this at times to that "of a water-closet". It had bled several times. During the day she suffered comparatively little pain, of a " gnawing" character; but at night a most intense pain was superadded, which she described as of " a -plunging nature, as if a bundle of forks were driven into the part". She was, considering her age and sufferings, a remarkably healthy looking old woman, with a tolerable amount -of flesh on her extremities, her mental faculties most perfect, her spinrts excellent. Two days after she had been in the hospital, Mr. Marshall removed the foot at the ankle-joint. Atatomny of the Growth. Its most marked character was that, by gently insinuating the handle of a scalpel, the growth could be split up into several portions: a section through its substance shewed this to depend on the columnar structure it possessed, allowing its separation into papilliform shreds. Some poitious, however, consisted of a mere granular pulp of broken up structures. The general colour of the section was dead white, but the individual papillie had a degree of opalescence. Portions of these were examined microscopically, and then found to consist of epithelium scales, similar to those of healthy cuticle; but in some fields of view multitudes of nuclei were alone seen, the outlines of the epithelium cells been concealed) when in several layers. After a prolonged stay in the hospital, several abscesses and sinuses having formed in the course of the healing of the operation-wound, she u! tiuately made an excellent recovery. August 14th, 1856. The stump continues perfectly sound, being constituted by a firm thick pad of flesh: about an inch above this there is in front a very narrow firm cicatrix. She feels " throbbiing" pains in the stump, simlar to those she felt formerly in the corn, before the weath er ebanges. She walks onee a week to St. Pancras Weorkhouse and back with the aid of a stick. She told me she was seventy-four years of age the 16th of last NMarch, and continues in excellent health. Here we have a case of, what the German pathologists would call, the most " exquisite" epithelial cancer, which has not returned three years after amputation. The only objection that arises is, How are we to explain away those cases, where, after removal of the primary disease, the disease returns not in its original situation, but after perhaps a considerable lapse of time in the adjacent lymphatic glands? Yet we have two important points in support of the nonconstitutional nature of the disease. 1. That these growths appear to kill by their purely local effects: involvement of vital organs, pain, discharges, and h-w-norrhages. I do not remember ever having sece a cachectic state produced independent of such effects. 2. Thlat it is extremely rare to find secondary deposits in the viscera in Iost mortema ex' aminations of cases of epithelial caucer, of however long duration.*
|
2022-07-04T22:31:52.141Z
|
249,527,789 |
{
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"ArXiv": null,
"DOI": "10.25199/2408-9613-2021-8-4-30-33",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.riri.su/jour/article/download/265/259"
}
|
The article describes the complex surgical treatment of a patient with a bilateral hip phlegmon complicated by severe sepsis, multiple organ failure syndrome (cardiac, respiratory), as well as deep pressure ulcers of various depths and localization under the primarily diagnosed diabetes mellitus.
|
2022-06-12T10:09:44.981Z
|
220,290,879 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3102/0034654311399732",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
As a visionary organ izat ion , NAIES seeks solutions to problems relating to social jus t i ce and the wedding of the academic and non-academ i c commun i t i es . The authors for this issue of Ezp ZoPa t ions have presen t e d information reflecting the concerns of t h e organi za t i on as a whole , but this information equals nothi ng i f you file it convenient ly upon your we l l-organ ized booksh el f .
|
2022-08-19T21:11:22.418Z
|
96,302,938 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/BBPC.19920961146",
"MAG": "2000057911",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Li was adsorbed at room temperature (RT) onto UHV cleaved 2H WX2 (X = S, Se) and 1T TaS2 (0001) van der Waals surfaces. On TaS2 Li is intercalated in terms of the rigid band model leading to several phase transitions of the charge density waves. On WX2 Li is intercalated for low concentrations and leads to a decomposition reaction to Li2S and W0 for high concentrations. These experimental results and those of previously studied alkali/layered chalcogenide combinations and their reactivity are discussed in terms of thermodynamic, kinetic and electronic effects.
|
2022-06-01T08:54:51.227Z
|
763,972 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/ctr.12809",
"MAG": "2462373920",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Inadequate bowel preparations can necessitate early repeat of colonoscopy and increased healthcare costs. Established risk factors for suboptimal bowel preparation are known, yet data are lacking in the specific subgroup of patients with decompensated cirrhosis. The primary aim of this study was to reduce inadequate bowel preparation rates in patients with decompensated cirrhosis undergoing evaluation for liver transplant via a quality improvement initiative targeting patient education.
|
2022-12-03T02:24:24.767Z
|
28,467,313 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.1053/j.jfas.2009.07.010",
"MAG": "2001791335",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
UNLABELLED
The authors report an unusual case wherein a fasciocutaneous free flap from an amputated upper limb was used to repair a severe soft tissue injury of the ipsilateral forefoot and ankle. After amputating the nonviable portions of the forefoot, a residual limb flap from the patient's forearm, pedicled with the brachial artery, was used to cover the lower extremity defect. Three years after the injury, the patient was able to maintain balance and ambulate without assistance on the reconstructed lower extremity.
LEVEL OF CLINICAL EVIDENCE
4.
|
2022-02-12T14:16:06.783Z
|
21,207,859 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1248/BPB.27.851",
"MAG": "2092043118",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
For the purpose of screening of inhibitors that are effective for wide range of metallo-beta-lactamases, the inhibitory effect of two series of compounds, 2-omega-phenylalkyl-3-mercaptopropionic acid (PhenylCnSH (n=1-4)) and N-[(7-chloro-quinolin-4-ylamino)-alkyl]-3-mercapto-propionamide (QuinolineCnSH (n=2-6)), where n denotes the alkyl chain length, on metallo-beta-lactamases IMP-1 and VIM-2 was examined. These inhibitors contain a thiol group and a hydrophobic group linked by variable-length methylene chain. PhenylCnSH (n=1-4) was found to be a potent inhibitor of both IMP-1 and VIM-2. PhenylC4SH was the potent inhibitor of both IMP-1 (IC(50)=1.2 microM) and VIM-2 (IC(50)=1.1 microM) among this study. When the number of methylene units was varied, QuinolineC4SH showed the maximum inhibitory activity against IMP-1 and VIM-2 (IC(50)=2.5 microM and IC(50)=2.4 microM). The relationship between the inhibitory effect of the alkyl chain length was different for both series of inhibitors, suggesting that IMP-1 has a tighter binding site than VIM-2. QuinolineCnSH did not serve as a fluorescence reagent for metallo-beta-lactamases.
|
2022-12-12T00:15:07.261Z
|
46,382,087 |
{
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"ArXiv": null,
"DOI": "10.2174/156652312802762536",
"MAG": "2167507894",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Several viral and non-viral vectors have been developed for exogenous protein expression in specific cells. Conventionally, this purpose is achieved through the use of recombinant DNA. But mainly due to the risks associated with permanent genetic alteration of cells, safety and ethical concerns have been raised for the use of DNA-based vectors in human clinical therapy. In the last years, synthetic messenger RNA has emerged as powerful tool to deliver genetic information. RNA vectors exhibit several advantages compared to DNA and are particularly interesting for applications that require transient gene expression. RNA stability and translation efficiency can be increased by cis-acting structural elements in the RNA such as the 5'-cap, the poly(A)-tail, untranslated regions and the sequence of the coding region. Here we review recent developments in the optimization of messenger RNA as vector for modulation of protein expression emphasizing on stability, transfection and immunogenicity. In addition, we summarize current pre-clinical and clinical studies using RNA-based vectors for immunotherapy, T cell, stem cell as well as gene therapy.
|
2022-12-25T22:50:21.726Z
|
11,771,836 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.1128/IAI.69.8.4988-4995.2001",
"MAG": "2059311311",
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},
"license": null,
"status": null,
"url": null
}
|
ABSTRACT The streptococcal pyrogenic exotoxins (Spes) play a central role in the pathogenesis of invasive group A streptococcal (GAS) infections. The majority of recent invasive GAS infections have been caused by an M1T1 strain that harbors the genes for several streptococcal superantigens, including speA, speB,speF, speG, and smeZ. However, considerable variation in the expression of Spe proteins among clonal M1 isolates has been found, and many of thespeA-positive M1 strains do not produce detectable amounts of SpeA in vitro. This study was designed to test the hypothesis that speA gene expression can be induced in vivo. A mouse infection chamber model that allows sequential sampling of GAS isolates at various time points postinfection was developed and used to monitor the kinetics of Spe production in vivo. Micropore Teflon diffusion chambers were implanted subcutaneously in BALB/c mice, and after 3 weeks the pores became sealed with connective tissue and sterile fluid containing a white blood cell infiltrate accumulated inside the infection chambers. Representative clonal M1T1 isolates expressing no detectable SpeA were inoculated into the implanted chambers, and the expression of SpeA in the aspirated aliquots of the chamber fluid was analyzed on successive days postinfection. Expression of SpeA was detected in the chamber fluid as early as days 3 to 5 postinfection in most animals, with a significant increase in expression by day 7 in all infected mice. Isolates recovered from the chamber and grown in vitro continued to produce SpeA even after 21 passages in vitro, suggesting stable switch on of thespeA gene. A temporal relation between the upregulation of SpeA expression and the downregulation of SpeB expression was observed in vivo. These data suggest that in vivo host and/or environmental signals induced speA gene expression and suppressed speB gene expression. This underscores the role of the host-pathogen interaction in regulating the expression of streptococcal virulence factors in vivo. The model described here should facilitate such studies.
|
2022-12-27T16:21:12.984Z
|
186,807,709 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.30827/CAUG.V0I0.11021",
"MAG": "6570150",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Muy escasas son las referencias a Don Manuel de Rueda en el siglo XVIII y estas van dirigidas exclusivamentea su obra. En efecto,Manuel Salvador Carmona -uno de los mas relevantes grabadores academicos del siglo de las luces- redacta un informe, en 26 de Octubre de 1792, en el que recomienda a los grabadores espanoles lean y trabajen el libro de Manuel de Rueda. Unos anos antes, Rejon y Silva habia citado a Rueda, como autoridad, al pie de la mayoria de los terminosde grabado recogidos en su pionero y famoso diccionario,publicado en Segovia en 1788.
|
2022-02-08T10:55:38.206Z
|
158,547,225 |
{
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"ACL": null,
"ArXiv": null,
"DOI": "10.25145/j.recaesin.2018.76.008",
"MAG": "2803168118",
"PubMedCentral": null
},
"license": "CCBYNCND",
"status": "HYBRID",
"url": "https://riull.ull.es/xmlui/bitstream/915/7560/9/RCEI_76_%28%202018%29_08.pdf"
}
|
espanolAsi como el personaje del ‘terrorista’ (generalmente musulman o paquistani) esta presente en muchos filmes de Bollywood, el nacionalismo hindu esta tomando la iniciativa en la esfera politica del pais. Sin embargo el cine indio tambien puede hacerse eco de acontecimientos ocurridos en Paquistan, donde desde los anos Setenta se ha manifestado un proceso de islamizacion de la sociedad, con una indudable impronta wahabi. Estimo que la historia reciente de Paquistan intenta deshacerse de su legado hindostanico, a la vez que senalo que los estudios sobre el musulman en “Bollywood” pecan de simplificarlo como un arquetipo, si no una caricatura. Pero la frontera entre India y Paquistan, entre Yo y el Otro, es decir, entre musulmanes e hindues es mas porosa de lo que cabe imaginar, lo que me lleva a concluir en las opciones de mantenerla y subvertirla. EnglishThere is but no question that we can speak about the emergence of the (usually Pakistani or Muslim) ‘terrorist’ figure in many Bollywood films, and likewise there is the indisputable fact of the rise of Hindu nationalism in the political and public sphere. Indian cinema, however, may also be viewed in the backdrop of political developments in Pakistan, where the project of Islamicization can be dated to least the late 1970s and where the turn to a Wahhabi-inspired version of Islam is unmistakable. I argue that the recent history of Pakistan must be seen as instigated by a disavowal of the country’s Indic self, and similarly I suggest that scholarly and popular studies of the ‘representation’ of the Muslim in “Bollywood” rather too easily assume that such a figure is always the product of caricature and stereotyping. But the border between Pakistan and India, between the self and the other, and the Hindu and the Muslim is rather more porous than we have imagined, and I close with hints at what it means to both retain and subvert the border.
|
2022-02-08T23:41:53.352Z
|
54,117,775 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1212/WNL.59.4.654",
"MAG": "1530063201",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
edited by Neil Scolding, 446 pp., ill., Oxford, UK, Butterworth–Heinemann, 2001, $59.95
They say one should not judge a book by its cover. It is difficult, however, to ignore the cover design of Contemporary Treatments in Neurology , edited by Neil Scolding (who also had a hand in the cover design). The cover illustrations highlight past, present, and future neurologic treatments, and are set against a background text from 1807 entitled Primitive Physic, or an Easy and Natural Method of Curing Most Diseases by John Wesley. Although Scolding’s book has a more humble title, he makes it clear in the preface that the reader can expect to find an authoritative, evidence-based account of current and future treatments in neurologic disorders. In this respect, the book fulfills its promise.
There are 30 or so contributors, with the majority from the United Kingdom and the remainder from continental Europe. The American reader will come across some occasional pharmacologic and stylistic differences (such as the liberal use of the term “fits” for seizures).
The book opens with a useful chapter on the design, analysis, and interpretation of clinical trials in neurology, although for the “busy neurologist,” to whom the book is clearly directed, more emphasis on interpretation of trials would have been welcome. The remainder of the book is divided into sections on degenerative diseases of the nervous system, inflammatory disorders, metabolic diseases, vascular disease, and episodic neurologic diseases. The section on degenerative diseases includes individual chapters on the dementias, diseases of the basal ganglia, motor neuron disease, and a chapter on the management of cervical spondylosis. The section on inflammatory diseases includes chapters on MS, peripheral nerve, neuromuscular junction, and muscle disorders, as well as chapters on neurologic manifestations of systemic inflammatory diseases and neurologic infections. There is an outstandingly clear discussion …
|
2022-07-07T12:08:17.378Z
|
314,857 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1017/sjp.2016.8",
"MAG": "2290223820",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Abstract This study analyzes the role of Perceived Emotional Intelligence (PEI) on sources of job stress and mental health in 250 elementary school teachers from Jaén (Spain). The aim of the study was two-fold: (1) to analyze the associations between Perceived Emotional Intelligence (PEI), sources of occupational stress and mental health; and (2) to determine whether PEI moderates the relationship between sources of occupational stress and mental health. An initial sample of 250 teachers was assessed Three questionnaires, the Trait Meta-Mood Scale, the Sources of Stress Scale in Teachers and the Medical Outcomes Study 36-item Short Form Health Survey, were used to evaluate PEI, sources of occupational stress and mental health, respectively. Teachers with higher levels of emotional attention reported lower levels of mental health (r = –.30; p < .001), while teachers showing high emotional clarity reported better emotional role (r = .14; p < .05) and social functioning (r = .15; p < .05). Moreover, PEI components moderate the relationship between sources of occupational stress and emotional role. Specifically, each significant interaction (i.e., deficiencies x attention, adaptation x attention, and adaptation x clarity) made a small and unique contribution in the explanation of emotional role (all p < .05, all sr 2 ∼ .02). Finally, our results imply that PEI is an important moderator of teachers´ occupational stressors on mental health.
|
2022-12-15T05:36:14.265Z
|
8,955,344 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1242/jcs.02839",
"MAG": "1978785653",
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
An apical brush border is a characteristic of many mature epithelia. This dynamic structure consists of dense microvilli supported by F-actin bundles that protrude into the apical cytoplasm, where they are crosslinked by spectrin and myosin II to form the terminal web. Little is known about the terminal web, through which vesicles transit to and from the apical membrane. Analysis of mutations in βHeavy-spectrin, the Drosophila brush border spectrin, reveals that this protein is necessary for the maintenance of Rab5 endosomes in the midgut. As a consequence, an apical H+ V-ATPase that is probably responsible for lumenal acidification is lost both from the brush border and Rab5 endosomes. Epistasis tests indicate that βHeavy-spectrin is required during endocytosis after Dynamin and before Rab5-mediated endosome activities. These data are consistent with the location of spectrin in the terminal web, and suggest that this molecule is required for correct sorting decisions at the early endosome.
|
2022-12-21T17:52:09.515Z
|
19,204,307 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/LAWP.2018.2814051",
"MAG": "2794652702",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This letter presents a new wideband high-gain circularly polarized (CP) substrate integrated cavity excited antenna array for the 60 GHz applications. First, a 2 × 2-element CP array is proposed with an aperture-coupled two-arm spiral antenna as its radiating element, which can exhibit good CP radiation performance. Instead of the conventional lossy and complicated feed network, a simple but efficient excitation structure based on higher-order-mode (TE340) cavity resonance is used to feed the array. The higher-order-mode cavity feeds all of the radiating elements in the same phase and magnitude, and the resonant mode is excited by a single slot aperture. Then, the proposed 2 × 2-element CP array is used as subarray to implement a sequential-rotationally fed 4 × 4-element CP array. Measured results show that the array has a wide axial-ratio bandwidth of more than 18.8% (53–64 GHz) with a peak gain reaching 20 dBic occurring at 61 GHz. The radiation patterns of the array are generally symmetrical with its main beam fixed at boresight.
|
2022-12-22T18:59:01.662Z
|
214,651,460 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/14742250802178330",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The continuing popularity of all things ‘Celtic’ has spawned a number of recent books on the subject of Irish monasticism. Both these volumes are written by religious sisters and appear under the imprint of T & T Clark but they are very different in tone and substance. One provides a general survey of ground that has already been well covered while the other is a much more original study on the specific topic of the observance of canonical hours and monastic liturgy in the eighth century. Catherine Thom, an Australian nun who gathered most of the material for Early Irish Monasticism during visits to the British Isles in the mid-1990s, admits that her book began as a study of the ‘suppression’ of the Celtic Church by Rome at the Synod of Whitby in 664. Although she soon came to realise that this was a misconceived project, resting on an over-simplistic and over-polarised understanding of what happened at Whitby, she remains firmly in the camp of those who posit a distinct Celtic consciousness, theology and church over and against an equally monolithic and distinct Roman church. While acknowledging the scholarly debate as to whether it is really meaningful or appropriate to speak of a ‘Celtic Church’, she uses the term freely herself. She is even more inclined to use the terms ‘Celticness’ and ‘Celtic Consciousness’ which she defines, somewhat bafflingly, at one point (page 42) as ‘a stress on the individual as recalcitrant and unorthodox, with a theology that is eclectic and pragmatic’. The influence of the wildly romantic and imaginative Irish scholar Noel O’Donoghue is evident here and in other places in this book and it is not surprising to read him being singled out for special praise in the acknowledgements. There is more than a whiff of Celtic twilight romanticism in the pages that follow, combined with a rather tortuous and archaic prose style that does not always make for easy reading. The third chapter, on Irish monastic rules of the sixth to the eight centuries, for example, begins with a somewhat opaque disquisition on the importance of acknowledging both the individual and communal aspects of the person: ‘Each is different yet complementary in that the whole coin would not exist without both sides. They reveal different aspects of the coin but contribute to the wholeness thereof. The dilemma and tension this identifies and the resolving thereof are an important endeavour of monastic striving’ (p. 77). Once one has navigated one’s way round these and other less than limpid passages in the book, what is left is an account of the main principles of Irish monasticism from the sixth to eighth centuries which relies fairly heavily on secondary sources. There are International Journal for the Study of the Christian Church Vol. 8, No. 3, August 2008, 252–264
|
2022-01-27T02:43:39.769Z
|
223,618,037 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3760/CMA.J.ISSN.1671-7368.2012.04.021",
"MAG": "3031975886",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
To observe the D-dimer levels and the numbers of micro-embolic signals (MES) in atrial fibrillation patients with different thromboembolic risk scores. A total of 216 persistent atrial patients were classified according to their different scores with a range of 0 -6.They were also divided into two groups by ≥2 or ＜ 2 according to the CardiacFailure,Hypertension,Age,Diabetes,Stroke 2 (CHADS2) point system.D-dimer levels and the numbers of MES were detected in all patients.A rising trend of D-dimer level and the number of MES was observed with the increases of CHADS2 score. D-dimer level and the number of MES in group 0 or 1 score were significantly lower than those in other high score groups (P ＜ 0.05).And the number of MES in group 5 or 6 score was significantly higher than those in other low score groups (P ＜ 0.05).D-dimer level and the number of MES in the group of ≥ 2 score were significantly higher than those in group ＜ 2 score ( P ＜ 0.01 ).It suggests that D-dimer level and the nunber of MES may reflect the thromboembolic risks in atrial fibrillation patients.
Key words:
Atrial fibrillation; Thromboembolic; D-dimer
|
2022-02-08T00:34:38.632Z
|
233,309,767 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4045/tidsskr.20.0775",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBYND",
"status": "GOLD",
"url": "https://tidsskriftet.no/node/60755/pdf"
}
|
Many medicines prescribed for older patients have an unintended anticholinergic effect in addition to the primary intended effect. This may lead to adverse reactions such as dizziness and memory loss, particularly in older people. Before prescribing new medicines, it is therefore important to assess the total anticholinergic burden by means of specific screening tools, such as AGS Beers Criteria® and the STOPP/START criteria. If the anticholinergic burden is high, drugs should be replaced or discontinued.
|
2022-03-25T01:20:36.585Z
|
231,711,493 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1123/jsr.2020-0231",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
CONTEXT
Little research has examined health-related quality of life in former National Football League (NFL) players.
OBJECTIVE
Examine the association of musculoskeletal injury history and current self-reported physical and mental health in former NFL players.
SETTING
Cross-sectional questionnaire.
PATIENTS OR OTHER PARTICIPANTS
Historical cohort of 2,103 former NFL players that played at least one season between 1940 and 2001.
INTERVENTION
Players were grouped by self-reported professional career musculoskeletal injury history and whether injuries affected current health: (1) no musculoskeletal injury history; (2) musculoskeletal injury history, currently affected by injuries; and (3) musculoskeletal injury history, not currently affected by injuries.
MAIN OUTCOME MEASURE
The Short Form 36 Measurement Model for Functional Assessment of Health and Well-Being (SF-36) yielded physical and mental health composite scores (PCS and MCS, respectively); higher scores indicated better health. Multivariable linear regression computed mean differences (MD) among injury groups. Covariates included demographics, playing history characteristics, surgical intervention for musculoskeletal injuries, and whether injury resulted in premature end to career. MD with 95% CI excluding 0.00 were deemed significant.
RESULTS
Overall, 90.3% reported at least one musculoskeletal injury during their professional football careers, of which 74.8% reported being affected by their injuries at time of survey completion. Adjusting for covariates, mean PCS in the "injury and affected" group was lower than the "no injury" (MD = -3.2; 95% CI: -4.8, -1.7) and "injury and not affected" groups (MD = -4.3; 95% CI: -5.4, -3.3); mean MCS did not differ.
CONCLUSION
Many players reported musculoskeletal injuries, highlighting the need for developing and evaluating injury management interventions.
|
2022-02-07T22:17:38.841Z
|
144,855,274 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1300/J293V11N02_06",
"MAG": "2062473195",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
SUMMARY An experimental design was attempted to test the effectiveness of self-help group participation among people with severe and long-standing mental illnesses. A sample of 90 individuals was randomized to either experimental or control groups with experimentals invited to join self-help groups and given outreach to encourage participation. Control subjects were not invited to join self-help groups. Results showed low rates of 17% participation in the self-help groups for both experimental and control subjects. The small number of experimental subjects participating and the presence of cross-overs from the control group yielded a sample too small for statistical analyses and the experiment was ended. Post hoc analyses comparing subjects who participated in self-help (15), non-participating subjects (75) and a comparison group of existing self-help group members (90) showed participants to have more severe psychiatric symptoms than either non-participants or members. Participating subjects were more li...
|
2022-09-10T02:54:05.553Z
|
98,066,928 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2116/BUNSEKIKAGAKU.54.939",
"MAG": "2054202653",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
石油試料の前処理として酸素高圧燃焼法による分解，キレート樹脂による濃縮を行い，誘導結合プラズマ質量分析法（ICP-MS）による希土類元素の多元素同時分析法の確立を目指した．酸素高圧燃焼法による分解では，石油試料1.0 gを使用し，燃焼酸化物の吸収液として5％ HNO3－1％ H2O2水溶液5 mlを容器内にセットし，3 MPaまで酸素を圧入，燃焼させた．キレート樹脂を用いた濃縮では，上記吸収液をアンモニア水を用いてpH 4に調節し，キレート樹脂（Chelex 100）1.0 gを入れかくはんした．その後，キレート樹脂に吸着したイオンを2 mol/l HNO3で溶離し10 mlの測定溶液とし，ICP-MSによる測定を行った． 測定の際にScにはBe，Y～SmにはIn，Eu～LuにはReを内標準元素として用い，更にBa及び希土類元素の酸化物・水酸化物の生成率を求めて質量スペクトル干渉の補正を行った．本法により実試料数種について希土類元素の定量を行った．
|
2022-09-13T05:06:37.113Z
|
239,712,767 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/1746-692x.12321",
"MAG": "3197785483",
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
Today, the food sector is largely excluded from climate protection policies. Nevertheless, the food sector is responsible for about 20 per cent of greenhouse gases. Food policies could substantially contribute to the EU’s ambitious climate goals. Currently, the debate on CO2‐e labelling is gaining momentum. Consumers know very little about the climate footprint associated with food choices. A climate label would strengthen consumer knowledge, may eventually influence food choices, could trigger reformulation efforts, raises awareness, and contribute to better informed discussions about climate policy. Based on a review of the current state of research and industry developments on designing CO2 footprint labels, this article provides recommendations on how to develop a clearly understood and trustworthy label. We propose a government approved, multi‐level, and categorical CO2‐e label, with colour coding and numeric CO2 equivalents; primarily based initially on median values. The design of the label should allow for an adoption of other environmental dimensions in the future. It should be scaled to weight (CO2‐e per kg) and apply to food products and meals. In the proposed form, a CO2‐e label is a low‐cost instrument. As more and more companies are already starting to label their products in different ways, consumer confusion is likely to rise if no uniform guidelines are established. Aujourd'hui, le secteur alimentaire est largement exclu des politiques de protection du climat. Il est neanmoins responsable d'environ 20 pour cent des gaz a effet de serre. Les politiques alimentaires pourraient contribuer de maniere substantielle aux objectifs climatiques ambitieux de l'Union europeenne. Actuellement, le debat sur l'etiquetage des equivalents CO2 (CO2‐e) prend de l'ampleur. Les consommateurs connaissent tres peu l'empreinte climatique associee aux choix alimentaires. Un label climatique renforcerait les connaissances des consommateurs, pourrait a terme influencer les choix alimentaires, et pourrait declencher des efforts de reformulation, sensibiliser et contribuer a des discussions mieux informees sur la politique climatique. A partir d’un examen de l'etat actuel de la recherche et des evolutions de l'industrie sur la conception d'etiquettes d'empreinte CO2, cet article fournit des recommandations sur la facon de developper une etiquette clairement comprise et digne de confiance. Nous proposons une etiquette CO2‐e approuvee par les pouvoirs publics, avec plusieurs niveaux et categories, et un codage couleur et des equivalents CO2 numeriques. Il serait principalement fonde initialement sur des valeurs medianes. La conception du label devrait permettre l'adoption d'autres dimensions environnementales a l'avenir. Il doit etre mis a l'echelle en fonction du poids (CO2‐e par kg) et s'appliquer aux produits alimentaires et aux repas. Dans la forme proposee, une etiquette CO2‐e est un instrument a faible cout. Comme de plus en plus d'entreprises commencent deja a etiqueter leurs produits de differentes manieres, la confusion des consommateurs risque de s'accroitre si aucune directive uniforme n'est etablie. Der Lebensmittelsektor wird gegenwartig von der Klimaschutzpolitik weitestgehend ausgenommen. Dennoch ist er fur etwa 20 Prozent der Treibhausgase verantwortlich. Die Lebensmittelpolitik konnte einen wesentlichen Beitrag zu den ambitionierten Klimazielen der EU leisten. Derzeit gewinnt die Diskussion uber ein CO2‐Label an Bedeutung. Verbraucherinnen und Verbraucher wissen haufig wenig uber den CO2‐Fusabdruck, der mit der Wahl ihrer Lebensmittel verbunden ist. Ein Klimalabel wurde nicht nur ihr Wissen uber den CO2‐Fusabdruck verbessern, sondern moglicherweise auch ihre Wahl von Lebensmitteln beeinflussen. Das CO2‐Label konnte daruber hinaus Anderungen in der Lebensmittelzusammensetzung anstosen, ein Bewusstsein schaffen und zu besser fundierten Diskussionen uber die Klimapolitik beitragen. Dieser Artikel gibt auf der Basis eines Reviews zum aktuellen Stand der Forschung und der Entwicklungen in der Lebensmittelindustrie Empfehlungen fur die Entwicklung eines leichtverstandlichen und vertrauenswurdigen Labels. Wir schlagen ein staatlich zertifiziertes, mehrstufiges und in Kategorien eingeteiltes Klimalabel mit Farbkodierung und numerischen CO2‐Aquivalenten vor, das zunachst uberwiegend auf mittleren Werten basieren soll. Die Ausgestaltung des Labels sollte daruber hinaus die Moglichkeit beinhalten, zukunftig auch andere Umweltdimensionen mit aufzunehmen. Es sollte sich auf das Gewicht (CO2‐Aquivalente pro kg) beziehen und fur Lebensmittel und Mahlzeiten gelten. In der vorgeschlagenen Form ist das Klimalabel ein kostengunstiges Instrument. Bereits jetzt kennzeichnen immer mehr Unternehmen ihre Produkte auf unterschiedliche Art und Weise. Die Kennzeichnungsvielfalt tragt zu einer steigenden Verwirrung der Verbraucherinnen und Verbraucher bei, falls keine einheitliche Festlegung von Richtlinien erfolgen sollte.
|
2022-12-17T10:09:45.301Z
|
18,281,641 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3346/jkms.2016.31.1.139",
"MAG": "2224610238",
"PubMedCentral": "4712573"
},
"license": "CCBYNC",
"status": "GOLD",
"url": "https://doi.org/10.3346/jkms.2016.31.1.139"
}
|
The time between symptom onset and arrival at an emergency department (ED) (S2D) is a crucial time for optimal intravenous reperfusion care for ischemic stroke. We aimed to analyze the effect of emergency medical services (EMS) utilization and inter-hospital transfer on S2D in Korea. Ischemic stroke patients were prospectively enrolled from November 2007 to December 2012 in 23 tertiary and teaching hospital EDs in Korea. Of 31,443 adult ischemic stroke patients, 20,780 were categorized into 4 groups based on modes of EMS utilization and inter-hospital transfer: direct transport to destination ED by EMS (EMS direct; n=6,257, 30.1%), transfer after transport to another ED by EMS (EMS indirect; n=754, 3.6%), direct transport to the ED without using EMS (non-EMS direct; n=8,928, 43.0%), and transfer after visiting another hospital without using EMS (non-EMS indirect; n=4,841, 23.3%). Our primary outcome variable was of S2D within 2 hr (S2D ≤2 hr) and found that 30.8% of all patients and 52.3%, 16.4%, 25.9%, and 13.9% of EMS direct, EMS indirect, non-EMS direct, and non-EMS indirect, respectively, achieved S2D ≤2 hr. Adjusted odds ratio for S2D ≤2 hr were 6.56 (95% confidence interval [CI], 5.94-7.24), 2.27 (95% CI, 2.06-2.50), and 1.07 (95% CI, 0.87-1.33) for EMS direct, non-EMS direct, and EMS indirect, respectively. Patients directly transported to destination hospitals by the EMS show the highest proportion of therapeutic time window for optimal care in ischemic stroke.
|
2022-12-18T11:30:28.574Z
|
156,199,539 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1017/CBO9780511902727.006",
"MAG": "2496103624",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This is a moment to seize. The Kaleidoscope has been shaken. The pieces are in flux. Soon they will settle again. Before they do, let us re-order this world around us. Tony Blair, 2 October 2001 THE COLLAPSIBLE SPACE BETWEEN US: HYPHENATED IDENTITIES IN THE TWENTY-FIRST CENTURY One of the many pivotal scenes in Roberto Bolano’s galaxial novel 2666 takes place at a lavish and decadent Nazi dinner party in a German castle, in the early days of the Second World War. One of the guests, a Romanian general named Entrescu, asks the assembled company whether Jesus Christ could have had any understanding of the global reach, in the twentieth century, of the church that was built in his name. Could he have suspected, he asks, that ‘his church would spread to the farthest corners of the Earth?’ Did Christ even have ‘what we today call an idea of the world? Did Jesus Christ, who apparently knew everything, know that the world was round and to the east lived the Chinese, and to the west the primitive peoples of America?’. Entrescu answers his own question, by remarking that of course Christ had no such idea, that such geographical knowledge was unavailable to him, notwithstanding his alleged omniscience. But Entrescu qualifies his own reply. ‘In a way’, he says, ‘having an idea of the world is easy, everybody has one, generally an idea restricted to one’s village, bound to the land, to the tangible and mediocre things before one’s eyes’ (p. 686).
|
2022-12-18T15:09:07.764Z
|
510,783 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4103/ijmpo.ijmpo_193_16",
"MAG": "2773844985",
"PubMedCentral": "5759075"
},
"license": "CCBYNCND",
"status": "HYBRID",
"url": "https://doi.org/10.4103/ijmpo.ijmpo_193_16"
}
|
Purpose: Nivolumab is one of the most extensively studied immune checkpoint inhibitors across various tumor types. In this narrative review, the current clinical efficacy and safety data of anti-programmed death-1 (PD-1) nivolumab for nonsmall cell lung cancer (NSCLC) and renal cell cancer (RCC) are elucidated. Methods: Systematic search was done on Pubmed, Medline, Embase, Web of Knowledge, and Cochrane Central through September 2016 for controlled prospective interventional studies of nivolumab across two indications - NSCLC and RCC. There was heterogeneity at all levels of abstraction; hence, author did not plan to provide a meta-analysis, but instead, a narrative elaboration of results structured around the conceptual frameworks. Results: Checkpoint receptor PD-1 is a negative regulatory molecule expressed by activated T and B lymphocytes. Binding of PD-1 to its ligands, programmed death-ligands 1 and 2, results in the downregulation of lymphocyte activation. Nivolumab is a fully human PD-1 immune checkpoint inhibitor. Nivolumab inhibits the interaction between PD-1 and its ligands and promotes immune responses including antitumor immune response and antigen-specific T-cell responses to both foreign antigens as well as self-antigens. In 2013, the Food and Drug Administration granted fast track designation for nivolumab in NSCLC, RCC, and melanoma. Conclusion: The encouraging literature on nivolumab lends credibility to the promise of immune checkpoint blockade, not just in terms of its feasibility as an oncotherapeutic strategy but also as a key tool of the future in the therapeutic approaches against advanced cancers.
|
2022-12-18T23:41:23.702Z
|
195,837,458 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3389/fnins.2019.00709",
"MAG": "2957986603",
"PubMedCentral": "6635473"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.frontiersin.org/articles/10.3389/fnins.2019.00709/pdf"
}
|
Limited in part by the spatial resolution of typical in vivo magnetic resonance imaging (MRI) data, recent neuroimaging studies have only identified a connectivity-based shell-core-like partitioning of the nucleus accumbens (Acb) in humans. This has hindered the process of making a more refined description of the Acb using non-invasive neuroimaging technologies and approaches. In this study, high-resolution ex vivo macaque brain diffusion MRI data were acquired to investigate the tractography-based parcellation of the Acb. Our results identified a shell-core-like partitioning in macaques that is similar to that in humans as well as an alternative solution that subdivided the Acb into four parcels, the medial shell, the lateral shell, the ventral core, and the dorsal core. Furthermore, we characterized the specific anatomical and functional connectivity profiles of these Acb subregions and generalized their specialized functions to establish a fine-grained macaque Acb brainnetome atlas. This atlas should be helpful in neuroimaging, stereotactic surgery, and comparative neuroimaging studies to reveal the neurophysiological substrates of various diseases and cognitive functions associated with the Acb.
|
2022-12-19T05:01:10.289Z
|
235,339,994 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/IEEECONF51394.2020.9443375",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This paper proposes a joint source-channel rate-distortion (RD) optimization for real-time video transmission. The video compression and forward error correction (FEC) options are optimized by looking for the best trade-off between the estimated end-to-end distortion of a video packet and the sum of the number of source bits and FEC bits used to encode that packet. Video coding options include coding mode and quantization parameter, which are selected for each macroblock. Channel coding options consist of different FEC code rates that provide different levels of protection against the lossy channel. The proposed RD technique adjusts the bit rate to meet a target using a Lagrange multiplier approach. The encoder also uses the instantaneous channel state information to improve performance for a varying channel. Conventional RD optimization approaches optimize over the video coding modes, and our approach which considers the channel and FEC bits as well has better performance over both AWGN and Rayleigh fading channels. We also consider an approach to reduce the computational complexity of the proposed RD scheme.
|
2022-12-20T22:13:20.837Z
|
162,312,727 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1017/S0041977X00073559",
"MAG": "2050790797",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
he marries Durga, born of Gauri's dark aspect; amra, kampai, and ambara are here irrelevant, and it seems probable that the incestuous marriages of *!§vetamba-Dvyamba narrated in an ' Ekambapurana ' represent the oldest material contained in the Kancipurarta. The symbolism of incest and plural mothers (light, dark, and mottled), as well as the dual vdsas of light and darkness, and the primordial tree (not, however, specifically mango or fig) may be observed in the Rgveda, but the immediate source of the Tamil original will have been proto-Jaina Prakrit.
|
2022-02-09T01:15:42.984Z
|
90,035,058 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1182/BLOOD.V112.11.27.27",
"MAG": "2567297599",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Introduction: Tumor formation results from a complex interplay between genetic/epigenetic alterations, cell cycle dysregulation and promotion by the tumor environment. Stimulation by extracellular survival factors is important for chronic lymphocytic leukemia (CLL), since the leukemic cells undergo spontaneous apoptosis when removed from their normal milieu. Since preliminary experiments demonstrated that macrophage migration inhibitory factor (MIF), a chemokine-like proinflammatory mediator and an intracellular regulator of growth and apoptosis, is overexpressed in human CLL, we investigated whether MIF participates in the pathogenesis of murine CLL. Methods: We studied the role of MIF in CLL by crossing the Eμ-TCL1-transgenic mouse model with MIF knockout (MIF−/−) mice. B-cell-specific overexpression of T cell leukemia-1 (TCL1) leads to accumulation and proliferation of IgM+/CD5+ mature B-cells via activation of AKT. This results in a CLL-like disease with peripheral lymphocytic leukemia, lymphadenopathy, splenomegaly, BM infiltration and premature death after 8–15 months. TCL1+/wtMIF−/− and TCL1+/wtMIF+/+ mice were compared with respect to leukemia development, tumor burden, cytogenetics and survival. Results: The MIF receptors CD74/CD44 and CXCR2 are expressed on murine B-cells. TCL1+/wtMIF+/+ mice exhibited increased numbers of IgM+/CD5+ B-cells already in the preleukemic phase at month 3 and developed overt leukemia (WBC > 20G/l) 3 months earlier than their MIF−/− counterparts (p = 0.02). Leukemia load at 12 months of age as measured by hepatosplenomegaly was increased in TCL1+/wtMIF+/+ animals and lymphatic organs were densely infiltrated by small, mature lymphocytes. The accelerated disease progression in the presence of MIF translated into a median survival which was 60 days shorter than in the absence of MIF (TCL1+/wtMIF+/+ 400 days, TCL1+/wtMIF−/− 460 days, p = 0.04). SKY analysis in leukemic splenocytes yielded various complex genetic aberrations with trisomies (e.g. +15), tetraploidy, translocations and deletions. Overexpression of tp53 due to the presence of an inactivating mutation in the p53 gene was found more frequently in TCL1+/wtMIF+/+ than in TCL1+/wtMIF−/− animals. Although the rates of DNA-damage-induced apoptosis in pre-leukemic and leukemic mice ex vivo were not significantly different between the genotypes, this defect in the p53-dependent apoptosis pathway corresponded with a reduced rate of spontaneous apoptosis in spleens of leukemic TCL1+/wtMIF+/+ animals. Conclusions: Our experience with the Eμ-TCL-1-transgenic mice shows that this model is suitable for the identification of novel regulators of CLL-like disease. We provide genetic proof that MIF acts to promote the early preleukemic and the leukemic phase of TCL1-induced CLL and thereby identify MIF as a novel regulator of CLL pathogenesis. Ongoing efforts are focussing on further characterizing the differences in pathology, the activation of the AKT pathway and cell cycle control between TCL1+/wtMIF−/− and TCL1+/wtMIF+/+ mice.
|
2022-11-20T15:24:35.264Z
|
245,559,621 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.14489/hb.2021.02.pp.034-038",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The activities of many enterprises are regulated by the requirements of national standards in the field of quality management, lean production, environmental management and labor protection. Despite the fact that these standards are oriented as independent subsystems of enterprise management, they have common elements, the implementation of which can be integrated. The article presents an analysis of the identity of the principles of the quality management system and the lean production system, regulated by GOST R ISO 9000–2015, GOST R 56020–2014 and GOST R ISO 10006–2005. Proposals are given for creating integrated management principles taking into account the requirements of GOST R 53893–2010, GOST R 55269–2012 and GOST R 57522–2017.
|
2022-01-27T15:37:12.547Z
|
153,188,340 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1163/ej.9789004177161.i-692.39",
"MAG": "747341938",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The origins and preparation of the tPrinciples of European Contract Lawt (hereafter tEuropean Principlest) were largely similar to those of the UNIDROIT Principles. The absence of comparative notes in the UNIDROIT Principles has been criticised on the ground that the indication of the national precedents for the solutions adopted in the UNIDROIT Principles would have conferred on them greater authoritative character. At first sight it may seem surprising that such similar instruments as the UNIDROIT Principles and the European Principles could have been elaborated more or less contemporaneously. In actual practice the UNIDROIT Principles and the European Principles have never overlapped so far but have played equally important, though not interchangeable, roles.Keywords: European Contract Law; UNIDROIT Principles
|
2022-02-09T02:29:15.461Z
|
39,969,707 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/MSMW.2013.6622046",
"MAG": "2084137292",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The dispersion equations for azimuthally asymmetric slow waves propagating along the plasma column, located in the dielectric cylinder are derived and solved. These waves induce currents that lead to the radiation of electromagnetic waves into the surrounding space. The antenna, which is a hollow dielectric cylinder of finite length, filled with an isotropic cold collisionless plasma is considered. The formulas for the angular distribution of the radiation in the far-field for azimuthally asymmetric and azimuthally symmetric slow current waves propagating along the antenna are derived. They can be used for case when the antenna length is much greater than antenna transverse dimensions and the radiated wave length. At that antenna radius, the thickness of the dielectric tube and dielectric permittivity, plasma density, the phase velocity and the wave current frequency can be arbitrary. Practically interesting case of a linear antenna of a traveling wave, which phase velocity is close to the speed of light is considered. Asymmetrical current wave with m=1 has a particular place. For it the maximum of directional diagram (pattern), unlike the asymmetric waves (m>1) and the symmetric wave (m=0), accounts for the direction of the antenna axis, and the side-lobe level is much lower than for the symmetric wave. The width of the pattern is decreased with increasing the ratio of the antenna length to the radiated wave length L/λ and is 17° for L/λ=10 and 12° for L/λ=20. Thus, the plasma antenna operating in the regime of the asymmetric wave current with m=1, can serve as a source of strictly axial radiation. It is shown that a sufficiently thin dielectric shell does not influence on the normalized radiation pattern.
|
2022-02-12T04:55:18.197Z
|
80,192,822 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1056/JW200408130000003",
"MAG": "2743653411",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Guidelines for treating HIV-positive patients continue to be revised as understanding of disease pathogenesis improves and additional antiretroviral
|
2022-02-11T03:23:59.975Z
|
247,507,380 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.21790/rvs.2022.21.1.1",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBYNC",
"status": "GOLD",
"url": "https://www.e-rvs.org/upload/pdf/rvs-21-1-1.pdf"
}
|
Postural orthostatic tachycardia syndrome (POTS) is a cerebrovascular autonomic dysfunction that is common in young women. POTS can cause dizziness due to orthostatic intolerance. In patients with orthostatic intolerance, it can be diagnosed when the heart rate increases by more than 30 beats per minute within 10 minutes of standing up through the head-up tilt test. However, even a neuro-otologist has difficulty in diagnosing POTS due to the high possibility of misdiagnosis if not paying attention. In this paper, the clinical symptoms, pathophysiology, diagnosis, and treatment of POTS are investigated. In addition, the latest knowledge of POTS is searched to help diagnose and treat POTS.
|
2022-04-01T01:38:40.400Z
|
52,190,178 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.17236/sat00173",
"MAG": "2890032624",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
INTRODUCTION
The aim of the study was to evaluate the molecular and histological effects of negative pressure wound therapy (NPWT) on vascularisation in clinical cases of open wound treatment in dogs. Open wounds (n=10) were randomly assigned to one of two groups: NPWT treatment (n=5) or foam treatment (polyurethane-foam dressing, n=5). Wounds were matched based on age and underlying cause and analysed with respect to neovascularisation (CD31) and matrix proteinase changes (MMP-9). Histological slides were blinded and analysis was performed using automated histomorphometric software. Values determined at day zero after debridement were used as a reference and wound development at day six was evaluated using linear mixed models. Signalment, pre-treatment time and underlying cause were similar between groups. NPWT resulted in a highly significant increase of vascularisation (p.
|
2022-08-20T15:42:50.155Z
|
82,918,513 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1248/CPB.9.709",
"MAG": "1598131851",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Synthesis of glycosyl-2-thiothymine from glycosylthiourea was carried out. Acetylation of 1-β-D-glucopyranosylthiourea with acetic anhydride, glacial acetic acid, and perchloric acid was found to give 1-(tetra-O-acetyl-β-D-glucosyl) thiourea and it was condensed with 2-methyl-3-methoxyacryloyl chloride. Cyclization of its product afforded 1-β-D-glucopyranosyl-2-thiothymine. In a similar manner, thiourea, prepared from tri-O-benzoyl-D-ribofuranosyl chloride through isothiocyanate, afforded 1-β-D-ribofuranosyl-2-thiothymine by the same method. The structure of all the compounds synthesized was established.
|
2022-09-08T11:27:36.624Z
|
17,208,827 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1161/01.HYP.13.4.361",
"MAG": "1984041314",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Hearts with advanced pressure-overload hypertrophy from systemic hypertension have been shown to have an increased susceptibility to the development of diastolic dysfunction in response to tissue hypoxia and ischemia. It is not known if this propensity to develop diastolic dysfunction in response to ischemia is dependent on the presence of a substantial increase in left ventricular mass, or alternatively, is characteristic of hearts subjected to mild chronic hypertension early in the development of cardiac hypertrophy. We tested the hypothesis that systemic hypertension associated with mild left ventricular hypertrophy increases the susceptibility to the development of diastolic dysfunction in response to demand ischemia. The effects of demand ischemia (6 minutes) were studied in hearts from New Zealand white rabbits with chronic systemic hypertension produced by the one-kidney, one-wrap method (n = 15) and compared with age-matched, sham-operated control rabbits (n = 11) with similar left ventricular mass (5.4 +/- 0.2 vs. 5.4 +/- 0.3 g, respectively). The hearts were studied using an isolated, isovolumic (balloon in left ventricle) preparation with absent pericardium that was perfused with fresh whole blood. At baseline, coronary perfusion pressure was 100 mm Hg with comparable coronary flow per gram left ventricular weight; the hearts were paced at a physiological rate of 3 Hz, and the left ventricular balloon volume was adjusted to achieve a left ventricular end-diastolic pressure of 15 mm Hg in both groups. Left ventricular balloon volume was similar in both groups and volume was thereafter held constant. At baseline, left ventricular systolic pressure (114 +/- 4 vs. 95 +/- 3 mm Hg, p less than 0.001) and developed pressure (18.9 +/- 1.2 vs. 15.1 +/- 0.9 mm Hg/g, p less than 0.05) were higher in the hearts from the hypertensive group in comparison with the control group. During the first minute of global ischemia produced by reducing coronary perfusion pressure from 100 to 20 mm Hg, there was an immediate fall in left ventricular systolic pressure in both groups without an increase in diastolic pressure. In response to the superimposition of pacing tachycardia (heart rate, 6 Hz) during the remaining 5 minutes of the period of ischemia, left ventricular developed pressure was comparable. However, isovolumic left ventricular end-diastolic pressure (measured during long diastoles obtained with transient cessation of pacing) rose to a significantly higher level in the hearts from hypertensive rabbits than in those from the control rabbits (29 +/- 3 vs. 18 +/- 2 mm Hg, p less than 0.01).(ABSTRACT TRUNCATED AT 400 WORDS)
|
2022-09-16T09:50:37.855Z
|
97,857,687 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/KIN.550030507",
"MAG": "2081726706",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
An experimental study of the decomposition kinetics of chemically activated 2-methyl-l-butene and 3-methyl-l-butene produced from photolysis of diazomethane-isobutene-neopentane-oxygen mixtures is reported. The experimental rate constants for 3-methyl-l-butene decomposition were 1.74 ± 0.44 × 108 sec−1 and 1.01 ± 0.25 × 108 sec−1 at 3660 and 4358 A, respectively. 2-Methyl-l-butene experimental decomposition rate constants were found to be 5.94 ± 0.59 × 107 sec−1 at 3660 A and 3.42 ± 0.34 × 107 sec−1 at 4358 A. Activated complex structures giving Arrhenius A-factors calculated from absolute rate theory of 1016.6 ± 0.5 sec−1 for 3-methyl-l-butene and 1016.2 ± 0.4 sec−1 for 2-methyl-l-butene, both calculated at 1000°K, were required to fit RRKM theory calculated rate constants to the experimental rate constants at reasonable E0 and E* values. Corrected calculations (adjusted E0 values) on previous results for 2-pentene decomposition gave an Arrhenius A-factor of 1016.45 ± 0.35 sec−1 at 1000°K. The predicted A-factors for these three alkene decompositions giving resonance-stabilized methylully radicals are in good internal agreement. The fact that these A-factors are only slightly less than those for related alkane decompositions indicates that methylallylic resonance in the decomposition products leads to only a small amount of tightening in the corresponding activated complexes. This tightening is a significantly smaller factor than the large reduction in the critical energy due to resonance stabilization.
|
2022-12-10T13:48:32.718Z
|
2,831,213 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/ICASSP.2011.5947312",
"MAG": "2160786347",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
With the electromagnetic theory as basis, we present a sensor model for three-axis magnetometers suitable for localization and tracking applications. The model depends on a physical magnetic dipole model of the target and its relative position to the sensor. Furthermore, the dependency between the magnetic dipole and the target orientation has been modeled enabling tracking of a maneuvering target. Due to multi-modality, a bank of Extended Kalman Filters is proposed for tracking road vehicles. Results from field test data indicate excellent tracking of target position.
|
2022-12-13T09:24:02.177Z
|
117,193,274 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5755/J01.EIE.25.1.22738",
"MAG": "2912162950",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Unmanned Aerial Vehicle (UAV) technology is being used increasingly for military and civilian purposes. The primary reason for this increase is that UAVs eliminate the risk to human life in difficult and dangerous missions, are cost effective, and easily are deployed. Developments in UAV technology and decreasing costs have increased UAV usage. However, when multiple UAVs are deployed, inter UAV communication becomes complicated. For this reason, communication in multi-UAV systems is the most important problem that needs to be solved. To enable communication among UAVs without infrastructure support, a Flying Ad Hoc Network (FANET) is used. A FANET provides UAVs to fly in tandem without colliding. To ensure coordinated flight, UAVs require the location information of other UAVs. In this study, we developed a common channel multi-token circulation protocol to share location information in multi-UAV systems that communicate using a FANET. The proposed method ensures that UAVs in multi-UAV systems know each other's coordinate information with minimum error.DOI: 10.5755/j01.eie.25.1.22738
|
2023-01-01T17:31:46.612Z
|
255,259,266 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.33854/heme.v4i2.955",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBYNCSA",
"status": "HYBRID",
"url": "https://jurnal.unbrah.ac.id/index.php/heme/article/download/955/pdf"
}
|
Introduction: Onychodystrophy can caused by variety of underlying diseases such as fungal and nonfungal infections, various noninfectious inflammatory dermatologic diseases of the nail unit and tumors. To establish the underlying disease leading to nail dystrophy as a first step one should differentiate between infectious and noninfectious disorders by obtaining nail material for microscopic examination and culture. Case Report: A case of onychodystrophy on twenty nail in 43 years old housewife woman was reported. The chief complaint was all of her fingernails and toenails were brittle, the color became yellow brown blackish since 6 month ago and sometimes excreted smell discharge. There were onychodystrophy, onycholysis, subungual hyperkeratosis and yellow brown blackish discolorization of all fingernails and toenail on physical examination. There were longitudinal striae, aurora borealis pattern, jagged margin of proximal edge on dermoscopic examination. Microscopic examination of nail clipping and scrapping of fingernails with 20 % potassium hydroxide was negative. The culture of fungi showed Candida Parapsilosis. Culture of bacteria was Staphylococcus aureus. PAS stain from nail clipping resulted was Candida Spp. Patient treated with oral pulse antifungal itraconazole 2x200 mg/day combination with ciprofloxacin 2x500 mg twice a day and ketokonazol cream twice a day. Conclusion: Onychodystrophy can caused by onychomycosis aggravated by bacterial infection. Diagnosis of onychomycosis candida was made base on diagnosis, physical examination, microscopic, culture and histopatology. Predisposition factor in this patient was chronic exposure with water. There is improvement clinical appearance after therapy with antifungal and antibiotic
|
2022-12-31T19:03:20.525Z
|
144,571,880 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1353/PGN.1996.0066",
"MAG": "2064170014",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
strange to find numerous individual entries for the metrical romances, summarising plots and detailing verse forms. Entries on Shakespeare's plays follow a formula: first, a plot summary for new readers which it is the business of such guides to offer; then some brief unexceptional evaluative judgement, a comment on a particular feature, such as its use of music, and, more exceptionable, one interpretative remark. Ben Jonson and other 'dramatists other than Shakespeare', together with individual piay entries, in m y sampling, make livelier reading. Chaucer scholars too can be pleased with the attractive impression given by the Chaucer entry. It is written by someone at ease with poetry. Not the same is true for Wyatt or Donne, sad to report. The most compelling entries are, one fears', on more recent writers. But there are exceptions in the earlier period, one being the entries on Elizabethan and Jacobean acting and theatre history, which are pithy and up to date. Though Ousby's 'Editor's Note' promises entries only for postGlobe buildings, in fact earlier theatres, the Rose for instance, are included. One is reminded of the mansion which was so vast that even the owner did know how many rooms, or windows, it had. Ann Blake School of English La Trobe University
|
2022-01-27T19:54:10.791Z
|
249,249,545 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.36803/ijpmr.v11i01.324",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBYNC",
"status": "HYBRID",
"url": "http://indojournalpmr.org/IJPMR/article/download/324/241"
}
|
ABSTRACT
Introduction: Spina bifida, a congenital spinal cord injury, is a complex disability that results from a failure of the caudal neural tube to fuse early in embryonic development. Spina bifida affects about 300.000 newborns each year worldwide. Hydrocephalus is common in children with spina bifida, developing in 80% to 90% of children with myelomeningocele. Anatomical abnormalities in which the myelomeningocele sac occurs is associated with neurological, motor and sensory deficits. They showimpaired speech and ambulation.Case presentation: We report a six-year-old boy was taken to the hospital by his parents because he could not stand and walk since he was born. At birth there was a lump on the lower back, and the patient also had hydrocephalus, then surgery had been performed. The patient was diagnosed with sixth lumbar spina bifida and hydrocephalus with meningocele. He had some delay in gross motor, fine motor and language development. The patient had history of seizures. He received trunk control exercise, pelvic stabilityexercise, positioning and handling, coordination exercises and fine motor skills to increase independence in activities of daily life. The patient obtained 4 years exercises of speaking, comprehension, vocabulary and articulation. The child also received attention and concentration enhancement exercises.Conclusion: A patient with spina bifida requires a lifelong commitment by the patient, family, and the health care personnel involved in the treatment. The medical goal is to maintain stable neurological functioning throughout the patient’s lifetime. The wide range of extensive speech and ambulation impairments and long-term disabilities in patients with spina bifida present a considerable challenge to the management of these patients.Keywords: ambulation, hydrocephalus, meningocele, speech, spina bifida
|
2022-06-04T15:01:55.789Z
|
122,997,039 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/17476930601065458",
"MAG": "2103507790",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In this article we obtain invariant two-point distortion theorems for univalent holomorphic mappings of the unit ball in one and in several variables. A new locally uniform minimum growth bound for biholomorphic mappings of the unit ball in dimension n>1 is obtained for those mappings with finite “norm order”. The results are framed in the context of linear invariant families and the Koebe transform. ¶Dedicated to Professor Peter L. Duren on the occasion of his 70th birthday
|
2022-08-27T15:09:56.878Z
|
2,656,394 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/WETICE.2013.46",
"MAG": "1966273264",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In the context of adaptive component-based systems, self-expression is the capability of changing the adaptation pattern at run-time when some changes occur in the system itself or in its environment. Even if functional requirements can be met without changing the adaptation pattern, the achievement of non-functional requirements, such as performance, can benefit from a change of adaptation pattern. The aim of this paper is to show, by means of a case study in swarm robotics, that a change of adaptation pattern can affect the performance of a system. In particular we show that the change of adaptation pattern can be useful in adaptive component-based systems to react to changes in the situation of the environment.
|
2022-09-13T14:26:39.217Z
|
35,902,988 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1663/0013-0001(2004)058[0456:EOSNLI]2.0.CO;2",
"MAG": "2163893221",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Ethnobotany of Sambucus nigraL. in Catalonia (Iberian Peninsula):The Integral Exploitation of a Natural Resource in Mountain Regions. Economic Botany 58(3):456-469, 2004. We present in this paper data about the popular uses of elder (Sambucus nigra) obtained in two ethnobotanical studies carried out in the districts (comarques) of Pallars Jussà and Pallars Sobirà (Pyrenees) and in the Montseny Massif (Catalan Prelittoral Range), complemented with others from different Catalan regions (also investigated by our group) and compared with those from other Iberian and Mediterranean territories. This bush or small tree belonging to the family Caprifoliaceae is one of the plants that have been most reported and used (for medicinal and other purposes) by the informants, not only in the two regions studied but in all Catalonia and in many Mediterranean areas as well. It is one of the most versatile of plants, being used for food, medicine, crafts and games, as well as for ornamental purposes. In addition, almost every part of the plant, including the bark, roots, leaves, flowers, and fruit, has some uses.ResumenPresentamos en este trabajo los datos sobre la utilizatión popular del saúco(Sambucus nigra) obtenidos en sendos estudios etnobotánicos llevados a cabo en las comorcas del Pallars Jussà y Pallars Sobirà (Pirineo) y el el macizo del Montseny (Cordillera Prelitoral Catalana), complementados por otros procedentes de distintas regiones catalanas (también investigadas por nuestro grupo), y comparados con los de otros territorios ibéricos y mediterráneos. Este arbusto o arbolito perteneciente a la familia Caprifoliaceae es una de las plantas más citadas y usadas (con fines medicinales y de otro tipo), no sólo en las dos regiones estudiadas, sino en toda Cataluña y en muchas zonas del Mediterráneo. Es una de las plantas más versatiles, puesto que sus usos comprenden campos muy diversos, tales como medicinal, alimentario, ornamental, artesanal y lúdico entre otros. Es de resaltar además la característica de que casi todas sus partes (corteza, raíz, hojas, flores, frutos) tienen algún uso.
|
2022-09-14T06:33:55.549Z
|
146,763,519 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/02732173.1992.9982008",
"MAG": "2166003574",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Poulantzas’ three class‐determining aspects of power (ownership, authority, and mental labor) are examined as predictors of individualism, which in turn is tested for its effect on political orientation. Of the three class dimensions considered, mental labor alone was found to have a significant effect on individualism. Although ownership had no significant attitudinal effect, it was the only class dimension of the three tested to directly influence political orientation. Individualism significantly predicted political party orientation, tending to be associated with Republicanism. Results are discussed in terms of the changing American class structure and its concomitant effects on future political trends.
|
2022-09-15T06:55:26.633Z
|
233,959,108 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1785/0220200215",
"MAG": "3133052304",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In response to the dramatic increase in earthquake rates in the central United States, the U.S Geological Survey began releasing 1 yr earthquake hazard models for induced earthquakes in 2016. Although these models have been shown to accurately forecast earthquake hazard, they rely purely on earthquake statistics because there was no precedent for forecasting induced earthquakes based upon wastewater injection data. Since the publication of these hazard models, multiple physics-based methods have been proposed to forecast earthquake rates using injection data. Here, we use one of these methods to generate earthquake hazard forecasts. Our earthquake hazard forecasts are more accurate than statistics-based hazard forecasts. These results imply that fluid injection data, where and when available, and the physical implications of fluid injection should be included in future induced earthquake hazard forecasts.
|
2022-09-15T09:22:27.191Z
|
146,885,826 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2307/846089",
"MAG": "2315414029",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
While most western democracies have renounced the death penalty, capital punishment enjoys vast and growing support in the United States. A significant and vocal minority, however, continues to oppose it. Against Capital Punishment is the first full account of anti-death penalty activism in America during the years since the ten-year moratorium on executions ended. Building on in-depth interviews with movement leaders and the records of key abolitionist organizations, this work traces the struggle against the pro-death penalty backlash that has steadily gained momentum since the 1970s. It reviews the conservative turn in the courts which, over the last two decades, has forced death penalty opponents to rely less on the litigation strategies that once served them well. It describes their efforts to mount a broad-based educational and political assault on what they see as the most cruel, racist, ineffective, and expensive manifestation of a criminal justice system gone wrong. Despite the efforts of death-penalty opponents, executions in the United States are on the increase. Against Capital Punishment diagnoses the reasons for the failure to mobilize widespread opposition to executions, and assesses the prospects for opposition to capital punishment in the future of the United States.
|
2022-09-15T12:43:39.640Z
|
25,024,670 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.1364/OL.28.000459",
"MAG": "1980805577",
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|
Bragg gratings are used in several photonic devices to reflect, and thus to isolate, specific wavelengths of light. Gratings can be photoinduced in chalcogenide glasses by illumination of bandgap light in an interference pattern. We used holographic interferometry to create Bragg gratings in amorphous As2Se3 thin films with a period of 0.56 microm by illumination with 633-nm light. The quality of the gratings was tested in real time, and refractive-index modulations as high as 0.037 were measured. These gratings were found to be stable over a period of several months if they were kept in the dark.
|
2022-12-17T10:21:40.266Z
|
16,625,131 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/ICISCE.2016.277",
"MAG": "2548713202",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Commonly, the analog self-interference cancellation (ASIC) can not eliminate self-interference completely in the co-time and co-frequency full-duplex (CCFD) system. Therefore, the self-interference cancellation in digital domain is essential to take the CCFD system into practical. A cancellation method based on least mean square Volterra (LMS-Volterra) algorithm is proposed in this paper, which can suppress the residual nonlinear self-interference in digital domain. The digital nonlinear self-interference cancellation model via the Volterra-series and LMS filter is built. Moreover, the detailed formulation of this cancellation procedure is derived. The expression of interference cancellation ratio (ICR) is achieved. This cancellation method can estimate the self-interference channel and suppress the residual nonlinear interference without the pilot sequence. Analysis and simulation results indicate the validity of the proposed digital nonlinear self-interference cancellation algorithm.
|
2022-12-18T15:23:25.252Z
|
237,748,679 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.7922/G2KK993X",
"MAG": "3181653593",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Author(s): Dowds, Jonathan; McRae, Glenn | Abstract: Climate adaptation is now a well-documented need in the transportation sector, and there are strong conceptual frameworks for the adaptation process. Since climate adaptation is an emerging field, the pathways for developing the skills and competencies for adaptation careers are not well established. This white paper assesses the workforce development needs and current training opportunities related to transportation-sector climate adaptation. To do so, training needs were examined and opportunities identified by state and regional transportation agencies; training needs of aspiring and early-career climate adaptation professionals were cataloged; and a scan was completed of the educational opportunities in climate adaptation currently offered by universities in the United States. There is evidence of convergence on the areas of content knowledge, technical expertise, and soft skills that form the core competencies necessary to support climate adaptation within the transportation sector. These core competencies are in climate science, adaptation strategies, communication, and selection of adaptation measures/decision making under uncertainty. While these competencies need to be broadly distributed throughout transportation agencies, the relative emphasis placed on each competency will vary across agency functions and job responsibilities. The increased value placed on adaptation-related expertise by state departments of transportation and regional transportation agencies, as well as the emergence of new educational and training opportunities in climate adaptation available in higher education and professional organizations, is indicative of the potential for rapid growth in this area.View the NCST Project Webpage
|
2022-02-07T20:42:56.230Z
|
134,443,048 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.22460/p.v1i4p441-454.809",
"MAG": "2899481623",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The research to discuss about using dialect Minang Language. At novel Terusir by Buya Hamka wuth using theory linguistics dialektologis social as a descriptive methods. In a novel Terusir consiset a Minang dialect language in daily activity. In this case have interpretation with Indonesian language in term of gramatical and lexical. Source of research Minang language in a novel Terusir by Buya Hamka using technique list that is writen and compared with Indonesian language. Analysis techniques in a research make a simple to understand utilized interpretation of Minang language in Indonesian language. The result from the research be found the same words, between dialect Minang in novel Terusir with Indonesian language in daily activiy. The quanty of different words between dialect Minang and Indonesian language it 12% word the percentage of utilized dialect Minang at the novel Terusir get 60 % (precents) this case indicate the work indine a using Minang language the compare with Indonesian language. Althought this work is refresments by readers majority except Minang
|
2022-02-09T12:08:28.386Z
|
126,101,927 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1121/1.4970756",
"MAG": "2554296746",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Vector flow mapping (VFM) is an echocardiographic approach for visualizing two-dimensional cardiac flow dynamics by estimating the radial component of flow from the Doppler velocities and wall motion velocities using mass-conservation equations. Although VFM provides two-dimensional flow in a clinically suitable, fast, and easy manner, it is only applicable to bounded regions such as ventricles. In this study, the VFM algorithm is modified so that the velocities are estimated regardless of the flow geometry. The proposed method, vascular VFM, operates on the same principle as VFM but with additional boundary conditions created by using Doppler velocities measured at a different steering angle. The method was optimized and validated using a common carotid artery phantom and particle-image-velocimetry (PIV). The results indicated that the optimal angle of an additional Doppler beam ranged from 10 to 20 degrees. Under this optimal-beam-angle condition, the standard deviation (SD) of total vascular VFM error,...
|
2022-02-09T16:24:35.092Z
|
198,884,488 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/24751839.2019.1630792",
"MAG": "2955676113",
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
ABSTRACT This article describes the solution of the problem of determining the ore belonging to a particular quarry in the multi-flow technological process of ore crushing at the ore enrichment fabric of a mining and processing plant. The paper proposes a new temporal model for solving this problem and describes its implementation in the form of an online monitoring system of ore quality and it belonging to a concrete quarry. This publication is an expanded version of the publication on The 10th Asian Conference on Intelligent Information and Database Systems (ACIIDS) 19–21 March 2018, Dong Hoi City, Vietnam (Toporov, Axelrod, & Tukeyev, 2018). The added material concerns issues related to the following aspects: – increased visibility of the object of monitoring of ore-preparation operations of concentrating mills, where, as a rule, ore of various quarries is processed; – detailing the functional structure of the automated system for operational monitoring of characteristics of processed ores; – an assessment of the adequacy of the operational model of the input characteristics of the processed ores and the adaptation of its parameters.
|
2022-03-18T01:11:10.201Z
|
23,900,735 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/UGIM.2010.5508942",
"MAG": "2098481756",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
University buildings are diverse in population and use. Some buildings have cafe's and undergraduate classrooms in the same buildings as the nano research that uses hazardous gases. Toxic gas monitoring systems are exanding on university campuses and at times the toxic gas systems need to interact with the buiding's fire alarm system. This paper describes various types of toxic gas monitoring systems and how they interact with the buildings fire alarm systems. When you install a large or small toxic gas system and then interface it with a fire alarm system a formal process needs to be develop and various parties need to be involved. This paper will describe Harvard Universities system for interfacing a TGMS with a FAS and vice versa.
|
2022-07-22T04:33:31.254Z
|
22,944,050 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1043/0003-9985(2002)126<0028:DROFEI>2.0.CO;2",
"MAG": "2175933479",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
CONTEXT
The mechanism by which human immunodeficiency virus 1 (HIV-1) infection causes increased rates of apoptosis and gradual chronic depletion of CD4(+) T lymphocytes in patients infected with HIV-1 is not known. Findings from in vitro culture studies and analysis of mononuclear cells in the peripheral blood of HIV-infected patients have led to the hypothesis that abnormal expression and/or interaction of Fas and Fas ligand (FasL) may play significant roles in the derangement of homeostasis of CD4(+) lymphocytes in patients infected with HIV-1.
OBJECTIVE
To determine the in situ expression of Fas and FasL in the lymph nodes of patients infected with HIV-1.
DESIGN
Immunohistochemical expression of Fas and FasL was studied in the lymph node biopsy specimens from 20 patients infected with HIV-1. As controls, we also studied 120 lymph nodes from 28 HIV-1-seronegative patients with reactive lymphadenopathy.
RESULTS
In the reactive lymph nodes of seronegative patients, expression of Fas was diffuse in the germinal centers and also in immunoblast-like cells in the T-cell regions. In the lymph nodes of patients infected with HIV, there was a consistent remarkable decrease in Fas expression in 12 of 20 patients and a total lack of Fas expression in the remaining 8 patients. Expression of FasL was comparable in both patient groups.
CONCLUSIONS
There is marked down-regulation of Fas in the lymph nodes of HIV-infected patients, a sharp contrast to what occurs in circulating mononuclear cells in the peripheral blood of these patients. These results indicate the need for further studies of this molecular event for possible therapeutic intervention based on reconstitution of Fas and/or FasL activity in the treatment of HIV infection.
|
2022-08-24T18:58:21.549Z
|
153,909,320 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1632/pmla.2008.123.5.1573",
"MAG": "2022358136",
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},
"license": null,
"status": null,
"url": null
}
|
and locus of racism from ethnic and color lines to religious and cul tural affiliations or differentials. Acting as a fully political apparatus, racism against Muslim and Arab Americans serves not only the ra tionalizing claims of the post-9/11 clampdown on civil liberties but also the derealizing aims of the global war on terror. In this introduc tion I sketch the history of this ideologically driven racism and show how Muslim and Arab American writers have sought not merely to expose but also to intervene in the material and palpable workings of the complicit apparatuses of racism and war. The essays collected here explore how an eclectic group of North American Muslim and Arab writers make use of diverse narrative forms to challenge the inimical image of Islam and Arabness as well as the continual violence of which it is simultaneously the target and the product. The essays conclude variably by analyzing the significance of human resilience and suffer ing in affirming a measure of communal and transnational solidarity.
|
2022-09-13T23:50:56.862Z
|
125,805,656 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.1142/S0219887818500755",
"MAG": "2779512618",
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},
"license": null,
"status": null,
"url": null
}
|
In this paper, we investigate homothetic Ricci collineations (HRCs) for non-static plane symmetric spacetimes. The source of the energy–momentum tensor is assumed to be a perfect fluid. Both degenerate as well as non-degenerate cases are considered and the HRC equations are solved in different cases. It is concluded that these spacetimes may possess 6, 7, 8, 10 or 11 HRCs in non-degenerate case, while they admit seven or infinite number of HRCs for degenerate Ricci tensor.
|
2022-12-02T10:54:50.396Z
|
20,991,832 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1056/NEJMOA021812",
"MAG": "2381269982",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
BACKGROUND
Adefovir dipivoxil, a nucleotide analogue, demonstrated clinically significant antiviral activity in patients with chronic hepatitis B in phase 1 and 2 clinical trials.
METHODS
We randomly assigned 185 patients with chronic hepatitis B who were negative for hepatitis B e antigen (HBeAg) to receive either 10 mg of adefovir dipivoxil or placebo once daily for 48 weeks in a 2:1 ratio and a double-blind manner. The primary end point was histologic improvement.
RESULTS
At week 48, 64 percent of patients who had base-line liver-biopsy specimens available in the adefovir dipivoxil group had improvement in histologic liver abnormalities (77 of 121), as compared with 33 percent of patients in the placebo group (19 of 57, P<0.001). Serum hepatitis B virus (HBV) DNA levels were reduced to fewer than 400 copies per milliliter in 51 percent of patients in the adefovir dipivoxil group (63 of 123) and in 0 percent of those in the placebo group (0 of 61, P<0.001). The median decrease in log-transformed HBV DNA levels was greater with adefovir dipivoxil treatment than with placebo (3.91 vs. 1.35 log copies per milliliter, P<0.001). Alanine aminotransferase levels had normalized at week 48 in 72 percent of patients receiving adefovir dipivoxil (84 of 116), as compared with 29 percent of those receiving placebo (17 of 59, P<0.001). No HBV polymerase mutations associated with resistance to adefovir were identified. The safety profile of adefovir dipivoxil was similar to that of placebo.
CONCLUSIONS
In patients with HBeAg-negative chronic hepatitis B, 48 weeks of adefovir dipivoxil treatment resulted in significant histologic, virologic, and biochemical improvement, with an adverse-event profile similar to that of placebo. There was no evidence of the emergence of adefovir-resistant HBV polymerase mutations.
|
2022-12-22T18:49:22.443Z
|
7,079,022 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/j.1365-2893.2006.00723.x",
"MAG": "2159131506",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Summary. CD4+ T cells are thought to contribute to antiviral immune responses by secretion of cytokines thereby providing help to CD8+ T and B cells. However, perforin‐positive cytotoxic CD4+ T cells have been described in human immunodeficiency virus‐positive patients suggesting a role not only of CD8+ but also of CD4+ T cells for killing virus‐infected cells. We investigated 76 patients with viral hepatitis [15 hepatitis B virus (HBV), 22 HBV/hepatitis D virus and 17 hepatitis C virus (HCV)] for cytotoxic CD4+ T cells. The frequency of perforin‐positive CD4+ T cells in viral hepatitis was highly variable ranging from <1% to more than 25%. Perforin‐positive CD4+ T cells displayed the phenotype of terminally differentiated effector cells (CD28−, CD27−). The highest frequencies of CD4+ cytotoxic T lymphocytes (CTLs) were found in patients with delta hepatitis (P = 0.04 vs HBV and HCV patients), and the presence of CD4+ CTLs was associated with elevated aspartate aminotransferase levels (P = 0.01) and decreased platelet counts (P = 0.03). Perforin‐positive CD4+ T cells decreased in two individuals during spontaneous clearance of acute hepatitis C. Significant associations were found between the frequency of perforin‐expressing CD4+ cells and age (P = 0.04), perforin‐positive CD8+ cells (P < 0.001) and perforin‐positive CD4−/CD8− lymphoid cells (P = 0.002). Differentiated CD27− effector CD4+ CTLs can be detected in patients with viral hepatitis. In particular in patients with more advanced liver disease, the accumulation of perforin‐positive T cells with age could be one correlate for the more severe course of viral hepatitis in elderly individuals.
|
2022-12-23T07:02:56.039Z
|
162,114,623 |
{
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"ArXiv": null,
"DOI": "10.4000/BALKANOLOGIE.2093",
"MAG": "1484106787",
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},
"license": null,
"status": null,
"url": null
}
|
C'est, a mon sens, un outil fondamental que nous offre H. Bozarslan, une introduction a l'histoire d'un pays deconcertant, qui, hier « quintessence » de l'Orient, est aujourd'hui candidat a l'integration dans l'Union Europeenne, unique pays industrialise au Proche-Orient, dont le regime possede certains traits de la democratie parlementaire. Il y a, habituellement, bien des mauvaises raisons d'admirer ce pays : nombre de Francais veulent y voir un doublon de leur Republique nationale, laique,...
|
2022-01-23T03:29:23.332Z
|
179,190,852 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.7508/ISIH.2010.08.006",
"MAG": "2247287002",
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},
"license": null,
"status": null,
"url": null
}
|
رویکرد بین رشته ای با تاکید بر ضرورت درک عمیق ماهیت متغیرهای مداخله گر در پیدایش و تکوین واقعیت ها و پدیده های اجتماعی و همچنین شناخت و تحلیل روابط متقابل و متعامل بین آنها، پهنه نوین و وسیعی از مطالعه و پژوهش را فراروی محققان و اندیشمندان حوزه های مختلف علوم گسترده است.براین اساس دانشگاهها و مراکز آموزش عالی در دهه های اخیر دوره ها و برنامه های آموزش بین رشته ای و چند رشته ای متعددی را در پاسخگویی به نیازهای جامعه طراحی و ارائه نموده اند. رویکرد بین رشته ای در معنای وسیع خود در برگیرنده فرایند جامع آموزشی شامل نیازسنجی، برنامه ریزی، تدوین محتوی، تعیین روش های آموزشی، پیش بینی و تدارک فرصت های یادگیری و نهایتا ارزشیابی فعالیت ها است. به همین دلیل در این مقاله به بررسی و تحلیل مفهوم ارزشیابی آموزشی بین رشته ای که از ضروریات و پیش نیازهای توسعه و تعمیق فعالیت های بین رشته ای در آموزش عالی است، پرداخته شده است.بحث محوری ارزشیابی آموزش بین رشته ای بر چگونگی اندازه گیری و ارزش گذاری تکالیف و امتحانات درسی در دوره های بین رشته ای متمرکز و معطوف است. به عبارت دیگر سئوال اساسی در این بحث این است که ملاک های ارزشیابی یک تکلیف بین رشته ای چیست؟ و آیا به صرف استفاده از مفاهیم رشته های علمی مختلف در انجام یک تکلیف می توان صفت و عنوان بین رشته ای را به آن اطلاق نمود؟ در این مقاله ضمن تبیین برخی نظریه های مرتبط با موضوع، دیدگاههای مانسیلا، دارسینگ، میلر و هانیس بطور ویژه مورد توجه قرار گرفته است. ارزشیابی تکالیف بین رشته ای اساسا بر مفهوم بنیادین «درک بین رشته ای» استوار است که بخشی از مقاله به توضیح این مفهوم پرداخته است. به دنبال آن «سطوح» چهارگانه «ساده»، «مقدماتی»، «حرفه ای» و «تخصصی»برای درک بین رشته ای مطرح و چهار بعد اساسی این درک شامل «هدفمندی»، «بنیان علمی»، «انسجام» و «نگرش نقادانه» معرفی و در پایان نیز ماتریس ارزیابی تکالیف بین رشته ای با تلفیق سطوح و ابعاد مذکور ارائه شده است.
|
2022-01-24T17:48:52.864Z
|
139,402,905 |
{
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"DOI": "10.32718/nvlvet9013",
"MAG": "2901767664",
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},
"license": "CCBY",
"status": "GOLD",
"url": "https://nvlvet.com.ua/index.php/food/article/download/2560/2544"
}
|
The article substantiates the possibility of using pears and cinnamon in technology of kefir that was manufactured by a thermostatic method. Natural sources of plant material are selected. It was selected a pear containing sugar, organic acids, enzymes, cellulose , tannins, nitrogen and pectin substances, vitamins C, B1, P, PP, carotene (provitamin A), flavonoids, phytoncides and cinnamon containing essential oils, tannins, resins, minerals and dietary fiber. The technology of preparation of pear fillers, namely, pear puree and pear jam, has been developed. The recipe for kefir with fillers is calculated. The expediency of using the certain ingredients of a beverage is substantiated. For fermentation of the normalized mixture, ferment Kefir 12 was used by Chr. Hansen company. The composition of this ferment includes Lactobacillus acidophilus, Lactobacillus rhamnosus, Lactococcus lactis subsp. lactis biovar diacetylactis, Leuconostoc mesenteroides, Bifidobacterium infantis, Bifidobacterium lactis, Lactobacillus fermentum, Lactobacillus lactis, Lactobacillus paracasei, Lactococcus lactis subsp. cremoris, Lactococcus lactis subsp. lactis. The optimum dose of ferment, which is 0.2–0.4% of the normalized mixture, is determined. Kefir was manufactured by thermostatic method. The normalized milk mixture with fillers was fermentated at a temperature of 27 to 29 °C for 5–6 hours. The mass fraction of fat in the finished product was 2.5%. The study of the change of active and titrated acidity during the fermentation of the product, as well as storage at the 7th and 10th days was conducted. The storage period of the resulting beverage, which is not less than seven days at a temperature of 4 ± 2 °С, is determined. The organoleptic and physico-chemical parameters of the finished product are described. Investigated physico-chemical and organoleptic parameters of kefir samples meet the requirements of DSTU 4417:2005 “Kefir. Specifications”. The use of pears and cinnamon in kefir production is expedient because of the product's enrichment with biologically active substances and the expansion of the assortment of dairy products.
|
2022-06-06T18:45:35.321Z
|
241,129,131 |
{
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"ArXiv": null,
"DOI": "10.26434/chemrxiv.12132939",
"MAG": null,
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},
"license": "CCBYNCND",
"status": "GREEN",
"url": "https://chemrxiv.org/engage/api-gateway/chemrxiv/assets/orp/resource/item/60c74a54842e656075db2efd/original/synthesis-and-mechanistic-interrogation-of-ginkgo-biloba-chemical-space-en-route-to-bilobalide.pdf"
}
|
Here we interrogate the structurally dense (1.63 mcbits/Å3) GABAA receptor antagonist bilobalide, intermediates en route to its synthesis and related mechanistic questions. 13C isotope labeling identified an unexpected bromine migration en route to an α-selective, catalytic asymmetric Reformatsky reaction, ruling out an asymmetric allylation pathway. Experiment and computation converge on the driving forces behind two surprising observations. First, an oxetane acetal is shown to persist in concentrated mineral acid (1.5 M DCl in THF-d8/D2O), and its longevity is correlated to destabilizing steric clashes between substituents. Second, a regioselective oxidation of des-hydroxybilobalide is found to rely on lactone acidification through lone-pair delocalization, which leads to extremely rapid intermolecular enolate equilibration. In addition, we describe multiple pitfalls, puzzles and unexpected reactions that ultimately uncovered a concise total synthesis. These problems arose from the high information density of bilobalide that distinguishes it from other scaffolds and may characterize natural product (NP) space more generally. Therefore, we also include a Python script to quickly (ca. 132,000 molecules/ minute) calculate information content (Böttcher scores), which may be helpful to identify important features of NP space.
|
2022-08-27T12:00:38.522Z
|
150,770,387 |
{
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"ArXiv": null,
"DOI": "10.17077/ETD.D5J2WKY1",
"MAG": "97520991",
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},
"license": null,
"status": null,
"url": null
}
|
Approved: ___________________________________ Thesis Supervisor ____________________________________ Title and Department ____________________________________ Date
|
2022-09-06T20:20:10.496Z
|
225,443,826 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.26782/jmcms.2020.07.00029",
"MAG": "3046328485",
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},
"license": null,
"status": "GOLD",
"url": "https://www.journalimcms.org/wp-content/uploads/journal_download.php?postid=4991"
}
|
The image-based Facial Emotion Recognition (FER) aims to classify the image into basic emotions being communicated by it. FER is one of the most prominent research areas in computer vision. Most of the existing works are aimed at high-quality images which are collected in the lab environment. These images are very different from the real-life facial emotion that leads to a lack of wild labeled data. Deep learning using transfer learning has shown promising results in computer vision in solving the problem of lack of labeled data. In the recent system, there is a great focus to overcome the lack of data issue in FER. Our paper has utilized the deep residual networks with inductive learning and self-attention module to overcome this problem. We have experimented different pre training settings and datasets for the model, which are Image Net and VGG face dataset (source datasets). The selfattention block is applied for better visual perspective to the model. Our target dataset is FER-2013, a benchmark dataset in FER. Trans FER is a deep residual network based on inductive learning and attention module. Our proposed approach has achieved superior performance than the existing state of the art models in the FER application using transfer learning.
|
2022-09-08T08:41:07.736Z
|
33,813,668 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/MSPCT.2013.6782094",
"MAG": "2043093802",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In this paper, we present an approach for counting blood cells during blood smear test. The approach presented in this paper eliminates the major problem of overlapping cells while counting by segmentation using morphological watershed transformation and regional maxima computation providing high degree of accuracy. Simulation results of counting red blood cells (RBCs), white blood cells (WBCs) and platelets in blood smear test images are also presented. The simulations are done in MATLAB®.
|
2022-09-13T12:43:11.910Z
|
238,131,773 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.48075/ijerrs.v2i2.26447",
"MAG": "3181768376",
"PubMedCentral": null
},
"license": "CCBYNCSA",
"status": "HYBRID",
"url": "https://e-revista.unioeste.br/index.php/ijerrs/article/download/26447/16839"
}
|
A busca por informações dos impactos ambientais gerados pelas atividades e setores econômicos tem aumentado. Neste contexto objetivou- analisar e comparar imagens de 18 anos para mais e para menos em relação ao ano de 2000 e pontuar o quanto houve de interferência na temperatura do planeta. Para tanto, foram realizados registros e feitas análises através de pesquisas bibliográficas a fim de correlacionar os assuntos propostos, selecionando artigos que pudessem dar apoio para criar uma hipótese, buscando os estudos mais recentes e importantes na área em função de palavras-chave relacionadas com o tema do artigo: aquecimento global e anomalias da temperatura média do ar. Fez-se necessário também os levantamentos de dados e mapas em sites como o INMET. Observou-se aumento de tendências às anomalias positivas no decorrer do tempo. Esse aumento nas diversas regiões do país, com as maiores anomalias no sul, sudestes e nordeste podendo estar relacionado às maiores ocupações populacionais e número de ações antrópicas nessas áreas. Pode -se destacar a pecuária (na região centro oeste principalmente) com as emissões de CH4 na atmosfera, gás com maior potencial de contribuição para o efeito estufa, bem como processos de industrialização no decorrer do tempo, nas diversas regiões do país. Conclui-se que os efeitos das mudanças climáticas já proporcionam problemas na disponibilidade de água para as atividades humanas, fator que poderá se agravar caso as alterações climáticas continuem nesse ritmo e não sejam desenvolvidos novos hábitos e políticas regionais voltadas para um planejamento eficaz dos usos múltiplos dos recursos hídricos.
|
2022-09-30T00:40:28.333Z
|
54,446,582 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.14740/wjon1143w",
"MAG": "2900938763",
"PubMedCentral": "6279458"
},
"license": "CCBYNC",
"status": "GOLD",
"url": "https://www.wjon.org/index.php/wjon/article/download/1143/898"
}
|
Background To investigate the clinicopathologic characteristics and prognostic factors of trichilemmal carcinoma (TC), and to determine an optimal treatment strategy for these patients. Methods This retrospective study enrolled consecutive patients who were admitted to the Sun Yat-sen University Cancer Center between 1998 and 2012. Results The key prognostic factors influencing the survival were lymph nodes metastasis and surgery margin. Multivariate analysis revealed that there was no risk factor for patient survival. Conclusions Surgery margin and lymph nodes metastasis were prognostic factors that influenced the treatment outcome. Simple excision with 1 cm margins is safe, inexpensive and effective for the treatment of TC; and postoperative follow-up of the patient to facilitate early diagnosis of the recurrence and distant metastasis is necessary. Systemic chemotherapy should be considered for the distance metastases patients.
|
2022-12-13T05:26:55.897Z
|
1,075,382 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1046/j.1537-2995.2001.41080988.x",
"MAG": "2036471691",
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
BACKGROUND: The immunomodulatory effects of allogeneic blood transfusion may contribute to a poor prognosis in patients with cancer who are undergoing surgery, and clinical trials have been carried out to investigate whether these patients would benefit from autologous blood donation. As the immunomodulatory effects of allogeneic blood transfusion have been related to soluble molecules released from residual WBCs during storage, the in vitro immunomodulatory activity of soluble molecules detected in supernatants from stored autologous blood was evaluated.
|
2022-12-16T15:14:21.565Z
|
244,274,645 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/APEMC49932.2021.9597011",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The introduction of information and communication technology in hospitals is rapidly expanding, with wireless communication systems integral to their smooth functioning. However, there are many problems that need to be addressed, such as signals that do not cover the required area or the inability to make a required connection. In medical wireless telemetry systems, the lack of a signal can be life-threatening if alerts about abnormalities in a patient's vital signs do not reach the staff. Many hospitals have problems with the reflection of radio waves from walls and floors, lack of consideration for the placement of metal fixtures, or not having appropriate space for cable routing. Reasons for these problems include the hospital construction process in which the planning of the installation of information and communication equipment is not done until after the building framework is completed and that information on the materials of walls, floors and doors is not shared among all stakeholders. To counter these problems, the Architectural Institute of Japan Steering Committee on Electromagnetic Environment organized a subcommittee to examine how building planners can better take into account the use of radio waves in hospitals. Our first target was to set guidelines for wireless medical telemetry systems. Herein, we show an overview of our guidelines.
|
2022-12-17T14:19:22.738Z
|