corpusid
int64 5
255M
| openaccessinfo
dict | abstract
stringlengths 1
10k
| updated
stringlengths 20
24
|
|---|---|---|---|
95,626,408 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1063/1.1733885",
"MAG": "1992422338",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The intensity of the fundamental vibration—rotation band of NO has been measured using the Wilson—Wells—Penner—Weber self‐broadening technique. The reported value is 111±7 cm—1/cm atm at 273°K, considerably higher than some previously published values, and in marginal agreement with other less precise previous determinations.
|
2022-09-04T02:39:30.132Z
|
94,384,084 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/EJIC.200700620",
"MAG": "1973791275",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A convenient method has been developed to bring together two discrete moieties of [Pt2(μ-S)2(PPh3)4] to give an open Pt4 aggregate of Pt2···(spacer)···Pt2, as exemplified in the isolation of [(PPh3)4Pt2(μ-S)(μ-SRS)(μ-S)Pt2(PPh3)4](PF6)2 [R = m-CH2C6H4CH2, p-CH2C6H4CH2, CH2C10H6CH2, and CH2(C6H4)2CH2]. The spacer is a dithiolate with an extended skeletal backbone formed from the alkylation of sulfide with a suitable dibromo-organic compound. This synthetic methodology can tolerate a range of conformationally contrasting thiolate substituents with different chemical functionalities. Shorter or stereochemically more restrictive spacers could opt to be an intramolecular bridge over the Pt2 core, as given in [Pt2(μ-S-o-CH2C6H4-C6H4CH2S)(PPh3)4](PF6)2. A few representative complexes have been characterized by single-crystal X-ray diffraction analysis.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
|
2022-09-10T08:57:06.482Z
|
34,984,107 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/MWSYM.1995.406020",
"MAG": "2164041241",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A novel technology that drastically improves output power and efficiency of amplifiers has been developed. A record high 74% power added efficiency (PAE) with an output power (Pout) of 31.4 dBm (1.4 W) has been achieved from an ion implanted GaAs MESFET at a low supply voltage of 3.5 V and 930 MHz, by optimally terminating second-harmonic source impedance as well as second-harmonic load impedance. By using this technology, a small sized (0.4 cc) power amplifier module for cellular phones has been developed. It has realized a high PAE of 66% with Pout of 31 dBm (1.25 W) under the condition of 3.5 V around 915-945 MHz band.<<ETX>>
|
2022-09-14T12:00:09.626Z
|
244,303,117 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/00138398.2021.1969096",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Abstract
Poe’s ‘The Masque of the Red Death’ turns on the paradox of a privileged elite succumbing to a plague that is ravaging society at large, and from which they believe themselves completely protected. The horror of the story consists not in the devastation of external society – that is taken for granted – but in the abject failure of the elite’s supposedly impregnable defences, their faith in which is exposed by the ‘Red Death’ as utterly delusory. ‘Put not your trust in Princes’ (Ps. 146.3) takes on an entirely new meaning.
|
2022-09-15T09:54:55.394Z
|
87,481,735 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2222/JSV.8.352",
"MAG": "2330265516",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
It was shown that poliovirus type I (Brunhilde strain) and type III (Nakamura strain) can be serially cultivated over many generations in the developing chick embryo and this can be verified by the interference diagnosis test which is specifically prevented by sera of monkeys taken during the convalescent phase of poliomyelitis.
|
2022-09-15T02:34:27.709Z
|
10,636,133 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/ICEEE.2006.251924",
"MAG": "2035228826",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Today, most routing problems are solved using Dijkstra's shortest path algorithm. Many efficient implementations of Dijkstra's algorithm exist and can handle large networks in short runtimes. Despite these advances, it is difficult to incorporate user-specific conditions on the solution when using Dijkstra's algorithm. Such conditions can include forcing the path to go through a specific node, forcing the path to avoid a specific node, using any combination of inclusion/exclusion of nodes in the path, etc. In this paper, we propose a new approach to solving the shortest path problem using advanced Boolean satisfiability (SAT) techniques. SAT has been heavily researched in the last few years. Significant advances have been proposed and has lead to the development of powerful SAT solvers that can handle very large problems. SAT solvers use intelligent search algorithms that can traverse the search space and efficiently prune parts that contain no solutions. These solvers have recently been used to solve many problems in engineering and computer science. In this paper, we show how to formulate the shortest path problem as a SAT problem. Our approach is verified on various network topologies. The results are promising and indicate that using the proposed approach can improve on previous techniques
|
2022-10-31T16:06:25.167Z
|
24,964,903 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/j.1365-2265.1992.tb02304.x",
"MAG": "2170158074",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
OBJECTIVE We investigated the relationship between age, sex, pituitary tumour volume, serum GH, PRL and IGF‐I levels with the responsiveness of GH to TRH, bromocriptine and octreotide in patients with acromegaly.
|
2022-12-15T23:37:51.205Z
|
122,688,696 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3788/COL201311.093001",
"MAG": "2149727755",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The structural, morphological, optical, and nonlinear optical properties of a lead sulfide (PbS) thin film grown by chemical bath deposition (CBD) are investigated by X-ray diffraction (XRD), scanning electron microscope (SEM), ultraviolet-visible (UV-Vis), and open aperture Z-scan experiments. The band gap energy of the PbS nanocrystalline film is 1.82 eV, higher than that of bulk PbS at 300 K. The nonlinear absorption properties of the film are investigated using the open aperture Z-scan technique at 1064 nm and pulse durations of 4 ns and 65 ps. Intensity-dependent switching of the film from nonlinear absorption to saturable absorption is observed. The nonlinear absorption coefficient increases monotonically with increasing pulse duration from 65 ps to 4 ns.
|
2022-12-16T11:39:35.330Z
|
41,157,771 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1051/PARASITE/1982572127",
"MAG": "182309938",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Oswaldofilaria samfordensis n.sp. is described from Physignathus lesueurii and a redescription of O. chlamydosauri (Breinl, 1913) from Chlamydosaurus kingii and Amphibolurus barbatus is given. O. pflugfelderi (Frank, 1964) is confirmed as a valid species. A key is added to separate the four Australian species in the genus. Gonocephalus boydii was recorded as a new host for O innisfailensis (Mackerras, 1962). A survey involving fifty specimens of P. lesueurii from South Queensland revealed that multiple infections with different filarioids are common and can include up to three different species in one individual animal. Pseudothamugadia physignathi (Johnston, 1912) (Splendidofilariinae) was the filarioid most frequently found, followed by O. Samfordensis and O. pflugfelderi
|
2022-12-16T15:09:36.669Z
|
7,032,630 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.12688/f1000research.4824.1",
"MAG": "1987961197",
"PubMedCentral": "4184311"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://f1000research.com/articles/3-197/v1/pdf"
}
|
Objective: To evaluate our unit’s theatre throughput efficiency, to identify where inefficiencies existed and consequently where the greatest improvement might be made. To identify the causes of day of surgery cancellations and how they might be avoided. Patients and Methods: A prospective audit of theatre utilisation was undertaken over a 6 month period between 05/02//2013 and 02/08/2013 at Ipswich General Hospital, QLD, Australia. Times collected were: time of patient arrival in anaesthetic bay, start time of operative procedure, end time of operative procedure, and time of patient leaving theatre. The causative factors for any delays or day of surgery cancellations were identified and recorded where possible. Results: In the six month period 26,850 sessional minutes were available for elective operating over 100 operating sessions. 304 elective cases were performed, split between 21 major and 283 minor procedures The sessions ran overtime a cumulative 2114 minutes. Total non-operative minutes totalled 13,209 (50.3% of all available time), split between late starts 499 minutes (1.8%), early list finishes 1894 minutes (7.05%), changeover time 1869 minutes (6.9%) and anaesthetic time, 8974 minutes (33.4%) Actual operating time only compromised 50.7% of all available elective operating session time (13,614 minutes) Theatre utilisation was 91.8%. 51 procedures were cancelled on the day of surgery during the audit period, representing 14.3% of all scheduled procedures. The most common reason for cancellation was lack of surgical fitness, followed by inadequate operative time. Conclusion: A significant proportion of all elective operative time was consumed by non-operative minutes. Inefficiencies existed in turnover of patients as well as over as well as underbooking of patients on elective lists. An excessive number of cases were cancelled on the day of surgery, wasting valuable operative time. A multi-parametric approach must be taken to improve operation list utilisation.
|
2022-12-19T18:22:30.251Z
|
137,480,954 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4028/www.scientific.net/MSF.704-705.102",
"MAG": "1988309908",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Multi-point forming (MPF) is an advanced flexible manufacturing technology for three-dimensional sheet metal forming. The substance of MPF is replacing the conventional solid dies by a set of discrete punches called ‘‘punch group’’. Because the reconfigurable discrete punches are used, part manufacturing costs are reduced and manufacturing time is shortened. However due to the discrete contacts between the workpiece and punches, the dimple defects occurred, which are inevitable and particular for MPF. For thick plate, the surface defect is the mainly dimple defect during its MPF process. In this study, elastic cushion was proposed to prevent these surface defects. The dynamic explicit finite element method was chosen to implement the simulation of MPF process. The Hill’s anisotropic yield criterion was used to describe the workpiece material behavior, and the elastic cushion was described with using the hyperelastic material model. The method to determine each punch position to construct forming surface was introduced. The MPF process with and without using elastic cushion was simulated to study the effect of the elastic cushion on preventing the surface defects. The relevant experiment was implemented, and it verified that the elastic cushion is effective method to suppress the surface defects during the thick plate MPF process. Keyword: flexible forming process (FFP), elastic cushion, surface defects, multi-point forming (MPF), thick plate, numerical simulation
|
2022-02-09T10:36:21.341Z
|
9,839,519 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1371/journal.pone.0100731",
"MAG": "2022667018",
"PubMedCentral": "4067348"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0100731&type=printable"
}
|
Lactic acid is an important chemical with various industrial applications, and it can be efficiently produced by fermentation, in which Bacillus coagulans strains present excellent performance. Betaine can promote lactic acid fermentation as an effective osmoprotectant. Here, positive effect of betaine on fermentation by B. coagulans is revealed. Betaine could enhance lactic acid production by protecting l-LDH activity and cell growth from osmotic inhibition, especially under high glucose concentrations and with poor organic nitrogen nutrients. The fermentation with 0.05 g/L betaine could produce 17.9% more lactic acid compared to the fermentation without betaine. Beet molasses, which is rich in sucrose and betaine, was utilized in a co-feeding fermentation and raised the productivity by 22%. The efficient lactic acid fermentation by B. coagulans is thus developed by using betaine and beet molasses.
|
2022-12-10T06:45:05.753Z
|
41,650,940 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1046/j.1440-1746.2002.02834.x",
"MAG": "2094301972",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Abstract Background: Microbial agents are a possible cause of ulcerative colitis. We have previously reported evidence of bacteria invading the colonic mucosa of patients with ulcerative colitis. We have isolated bacteria from inflamed colonic mucosa, examined the localization of the species in the mucosa, and assayed for serum antibodies to the bacteria.
|
2022-12-17T09:06:30.641Z
|
25,470,515 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/ijc.11436",
"MAG": "2078128814",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.11436"
}
|
Matrix metalloproteinases, and notably the gelatinases MMP‐2 and MMP‐9, have important roles in tumour invasion, metastasis and angiogenesis. Our study investigates the distribution of MMP‐2 and MMP‐9 in colorectal cancer, the correlation with plasma levels, changes following surgical resection and whether plasma levels reflect clinical staging and disease course. MMP‐2 and MMP‐9 expression in 48 colorectal tumours and 13 adenomatous polyps was analysed by RT‐PCR, immunohistochemistry, and quantified by ELISA of tumour lysates. Concentrations of MMP‐2 and MMP‐9 in plasma samples from these patients and 36 other patients who underwent curative resections were measured by ELISA prior to and 6–12 months after surgery. MMP‐2 expression was significantly increased in colorectal cancer tissues compared to matched normal colon as measured by ELISA. Active MMP‐2 was localised by immunohistochemistry to regions where tumour cells invaded the muscularis with little staining in more superficial areas. Plasma MMP‐2 levels were also significantly elevated in patients with colorectal cancer, with significant reductions following curative resections at all stages. Similarly, MMP‐9 expression was significantly increased in colorectal cancer tissues, predominantly in the tumour stroma. Plasma levels of MMP‐9 were significantly elevated at all stages in colorectal cancer patients and a significant reduction was seen following curative resections. With both MMP‐2 and MMP‐9, the strongest correlation with clinical staging in colorectal cancer was represented by the total plasma concentration of the enzymes, both falling to within the normal range following curative surgery. Plasma levels of these enzymes may therefore have potential as a noninvasive indicator of invasion or metastasis in colorectal cancer or as a marker of disease status during follow‐up. © 2003 Wiley‐Liss, Inc.
|
2022-12-24T17:56:07.721Z
|
54,652,967 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.13189/LLS.2015.030305",
"MAG": "904272072",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Historical fiction is a sub-genre of fiction, not history, since it often portrays fictional accounts or dramatization of historical figures or events. Historical fiction presents readers with stories that take place during a notable period in history and usually during a significant event in that period. Historical fictionists misrepresent historical "fact" in an attempt to achieve a certain artistic effect: to capture the social and cultural conditions of the people in a given time, with particular attention paid to accurate contemporary details often ignored by historians. This paper explores reasons why writers of historical fiction employ certain tactics when they write, such as lying and manipulating. Finagling an audience ties directly into Brown and Levinson's definition of Negative Face and so this paper also explores the intersection of B/L's politeness theory and creative writing, specifically how the relationship that exists between interlocutors in oral communication mirrors the same relationship between author and reader in creative fiction.
|
2022-02-11T20:50:53.593Z
|
56,303,351 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.18983/CASELE.19.0_53",
"MAG": "2577827792",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
1 . Background 1.1. Word order strategy in English A large body of crosslinguistic research investigating the subject role assignment in the three kinds of transitive verb sentence which consist of one transitive verb and two nouns (NVN, VNN, NNV) has extracted a specific function mapping onto these word orders by English native speakers viz., NVN=SVO, VNN=VOS, NNV=OSV. The latter two are called the 'second noun strategy' because the second noun is exclusively chosen as the sentence subject (Bates et al, 1982). These form-function mappings reflect the probabilistic occurrence of word order in I English. Macwhinney et al. (1984) cite some examples of the possible word order which should contribute to the second noun strategy of English native speakers.
|
2022-02-11T19:29:26.793Z
|
359,897 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2152/jmi.62.264",
"MAG": "2174474958",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://www.jstage.jst.go.jp/article/jmi/62/3.4/62_264/_pdf"
}
|
We report the case of a 50-year-old female Jehovah's Witness with advanced esophageal cancer who underwent esophagectomy following induction chemotherapy. She visited our hospital complaining of dysphagia and was diagnosed of advanced esophageal cancer by upper endoscopy. She refused allogeneic transfusion. Induction chemotherapy was performed. Severe anemia occurred as an adverse event. A subtotal esophagectomy was performed after her anemia improved. During the surgery, a large volume of replacement fluid was injected, the blood was diluted, and intraoperative bleeding was relatively reduced. Intraoperative blood salvage was made using Cell Saver. The postoperative course were stable by using autologous blood and albumin infusion. The patient was discharged on postoperative day 27. Jehovah's Witnesses with gastrointestinal malignancies can be treated safely by performing surgical therapy based on blood replacement therapy and autologous blood transfusion.
|
2022-04-22T04:43:17.142Z
|
240,717,571 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5194/epsc2021-521",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
<p>Studying the presence of water and characterizing the tectonic structure in the firsts tens of kilometers of the crust of the Galilean icy moons are crucial to understand the formation and evolution of these bodies and could provide an insight into the setting for extra-terrestrial life within our solar system (Nimmo and Pappalardo, 2016). The most promising technique for directly detecting subsurface oceans is a penetrating radar and the use of low frequencies (< 30 MHz) is preferred to probe the moons' subsurfaces since the losses due to the surface roughness and absorption of the ice are reduced (Bruzzone et al., 2011). However, Jupiter has a loud radio environment for frequencies < 40 MHz  (Cecconi et al., 2012), and the use of a passive mode, which would exploit Jupiter’s decametric radio emissions, is considered to operate the radar with low frequencies in the sub-Jovian hemispheres. However, the passive radar operates in a complex bistatic 3D geometry where Doppler and delay information are not separable. This justifies the use of simulations with realistic orbitographies to identify which configurations will lead to the best and worst performances, which is necessary to establish the scenarios of observation of the radar. In this paper, we compute the impact of the geometry on the final bistatic performances, using planned Juice orbits.</p>
<p>In order to study the influence of the geometry only, we do not take into consideration the stochastic character of Jupiter’s noise. The emission is then a simple impulsion located in the Jupiter auroral coronas:  we regard four sources, at the Eastern and Western borders of Jupiter’s North and South auroral coronas, as presented in Figure 1.</p>
<p>In this geometry, the passive radar is orbiting around Ganymede and studies the reflection of the Jovian signal by a point target at the nadir in a monostatic geometry, or a point making a specular reflection in the bistatic case. To recognize weak, delayed, and Doppler-shifted contributions of the Jovian signal (also called reference signal), cross-correlation is carried out between the registered Jovian signal and the measured reflection. The next signal processing is the computation of the SAR synthesis to retrieve a Range-Doppler map of the surface probed.</p>
<p> </p>
<p><img src="data:image/png;base64, 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
|
2022-01-27T04:19:40.500Z
|
52,815,100 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1145/3220267.3220289",
"MAG": "2890536207",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This paper introduces a model to analyze and predict students' performance based on two dimensions; teaching style, and eLearning activities. Such data will be collected from educational settings within an academic institution. The analyzed data is used to reveal knowledge and useful patterns from which critical decisions could be made.
The suggested model should be able to:
• Classify modules according to their module nature
• Analyze different kinds of students' interaction with eLearning
• Classify teaching styles and pedagogical approaches and their effect on students' performance
• Classify students and their final grades according to their background and characteristics.
• Utilize different correlation analysis and feature selection techniques
|
2022-09-29T22:45:02.722Z
|
72,371,024 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1076/noph.26.1.59.8051",
"MAG": "2061713100",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
To examine the reproducibility and sensitivity of flash visual evoked potential (VEP) testing in rabbits, we recorded the VEPs elicited by light stimuli in conscious rabbits from an active electrode placed on the primary visual cortex. We analyzed flash VEPs of rab-bits by detecting the first negative peak, which was designated N 1.We evaluated the effects of dark adaptation time (from 5 to 30 min) on the latency and amplitude of N 1, and the coefficient of variation (CV) of these parameters. Then, the intensity of photopic stimulation was varied using a neutral density (ND) filter from the standard 0.6 J to its -1.8 log unit energy level at 0.3 log unit decrements. The N 1 latency and amplitude were measured at each recording. There was no significant change in VEP latency or amplitude when the dark adaptation time was varied from 5 to 30 min (n = 7, P > 0.05, ANOVA). The CV of the N1 latency was 0.4% and that of the N1 amplitude was 4.2% (n = 6). The N1 peak latency was prolonged and its amplitude decreased sig-nificantly with the decrease in the stimulus intensity; the changes in latency and amplitude relative to the standard were significant (n =11, p < 0.001, ANOVA) and were strongly correlated with the reduction in the stimulus intensity (r = 0.90 and -0.80, respectively, Pearson's test). Also, the latencies and amplitudes were significantly different between all adjacent 0.3 and 0.6 log unit pairs of stimulus intensity, respectively. These results indicated that rabbit VEPs showed good reproducibility and a high sensitivity to light difference intensities, and that they may be useful not only to evaluate functional damage, but also to investi-gate the neuroprotective effect of drugs or cytokines.
|
2022-12-14T03:45:28.921Z
|
122,880,495 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1515/JGT.2006.012",
"MAG": "2133659753",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Abstract A generalized tetrahedron group is the colimit of a triangle of groups whose vertex groups are generalized triangle groups and whose edge groups are finite cyclic. We prove an improved spelling theorem for generalized triangle groups which enables us to compute the precise Gersten–Stallings angles of this triangle of groups, and hence obtain a classification of generalized tetrahedron groups according to the curvature properties of the triangle. We also prove that the colimit of a negatively curved triangle of groups contains a non-abelian free subgroup. Finally, we apply these results to prove the Tits alternative for all generalized tetrahedron groups where the triangle is non-spherical: with three abelian-by-finite exceptions, every such group contains a non-abelian free subgroup.
|
2022-12-15T06:39:20.876Z
|
9,606,616 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2188/JEA.8.258",
"MAG": "1964109279",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
To examine the impact of health-related lifestyle upon medical care utilization and its costs, we conducted a cohort study among all National Health Insurance beneficiaries aged from 40 to 79 years living in the catchment area of Ohsaki Public Health Center, Miyagi, Japan. The baseline survey, using self-completed questionnaire regarding health-related lifestyle, was conducted between October and December 1994. Out of 54,996 eligible subjects, 52,029 (94.6%) responded and formed the cohort under study. Medical care utilization (number of outpatient visits and days of inpatient care) and the costs for each subject have been obtained from National Health Insurance Claim History files since January 1995. The baseline characteristics of health-related lifestyle and medical history at the study subjects were consistent with those at our another cohort subjects (so-called Miyagi cohort study; N = 47,605), which included all the residents aged from 40 to 64 years at 14 municipalities in Miyagi Prefecture, Japan conducted in 1990. The medical costs per capita in this cohort was quite compatible with the national average. This prospective cohort study would quantitatively demonstrate the economic impact of health-related lifestyle, thus would lead us to better provision of cost-effective preventive health services.
|
2022-12-21T10:18:23.057Z
|
248,279,375 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.53724/lrd/v6n3.09",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBYNC",
"status": "HYBRID",
"url": "http://lrdjournal.com/index.php/lrd/article/download/153/220"
}
|
In this research paper, the meaning and definition of public opinion are discussed and how it affects the entire criminal justice system of India. Various factors are discussed which give a detailed idea of how public opinion influences police investigations and then court decisions. This research paper has also discussed the role of media in molding public opinion. There is a need to reorganize the criminal justice system so as to inspire public confidence by treating all fairly and providing a systematically high standard of service to victims and witnesses, and to provide more justice through a modern and efficient justice system in compliance with the rule of law. The criminal justice system should focus more on actual evidence and witnesses and less on public opinion when delivering justice. Only by ensuring equal justice for everyone, we can assure peace for all.
|
2022-04-22T04:41:13.251Z
|
146,134,522 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5195/JWSR.2010.439",
"MAG": "2196116206",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This is an explosive book, iconoclastic, myth-shattering, and profound. But it is also fine tuned and rich in detail, the work of a master (no pun intended) craftswoman. You have simply got to read this book. Wilma Dunaway has issued a provocative rebuttal to those who have argued that slaveholders rarely broke-up enslaved African families; that slaves were adequately fed, clothed, and sheltered; and that slave health or death risks were no greater than those experienced by white adults. According to Dunaway these weaknesses in much scholarly research stem from a flawed view of the slave family, scholarly neglect of small plantations, limited analysis of Upper South enslavement, and academic exaggeration of slave agency. Dunaways study relies largely on her analysis of slave narratives.
|
2022-07-20T01:36:49.967Z
|
237,644,264 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2139/ssrn.3889352",
"MAG": "3186442470",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Background: The healthcare workers (HCWs) have been on the frontline in combating the pandemic and were prioritized for vaccination when COVID-19 vaccines became available. Although vaccines effectively prevent infection in most cases, some cases of post-vaccination infections have been reported, raising concerns about vaccine efficacy. This study investigated the efficacy of COVID-19 vaccines in preventing and reducing the severity of post-vaccination infections (PVI) among HCWs.
Methods: This observational study examined 28342 vaccinated HCWs with SARS-CoV-2 (symptomatic severe acute respiratory syndrome coronavirus 2) infections during the initial five months of vaccination (January 16-June 15, 2021). They worked at 43 Apollo Group hospitals in 24 Indian cities. PVI was investigated after recombinant ChAdOx nCOV-19 (Recombinant) or the whole virion inactivated Vero cell vaccines were administered. Various parameters were evaluated such as age, sex, time to infection, type of vaccine, infections after a single and two doses, monthly and regional case distribution, clinical severity of infection, hospitalization and intensive care unit (ICU) requirement, and death.
Findings: Symptomatic PVIs occurred in a low percentage of vaccinated cohorts (5⸱07%, p 50 years significantly contracted more infections(p<0⸱001 and p=0⸱001, respectively). Two-dose vaccination has significantly lower odds of developing PVI (0.83, 95%CI – 0.72 to 0.97). Maximum infections occurred during the peak of the second COVID-19 wave from mid-April to May 2021 (p<0⸱001). No significant difference existed in the infection between sex, vaccine type, and the number of vaccine doses received (p≥0⸱05).
Interpretation: PVI occurred in a small percentage of HCWs. Vaccination protected them significantly from the infection but also severe disease.
Funding Information: None.
Declaration of Interests: None.
Ethics Approval Statement: This study was approved by an Ethical Institutional Committee (EIC), and a consent waiver was given by the EIC.
|
2022-07-29T09:46:01.021Z
|
198,709,120 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.18260/1-2--31176",
"MAG": "2956037752",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "https://peer.asee.org/31176.pdf"
}
|
Design of machine parts routinely focus on the dimensional and form tolerances. In applications where surface quality is critical and requires a characterizing indicator, surface roughness parameters, Ra (roughness average) is predominantly used. Traditionally, surface texture has been used more as an index of the variation in the process due to tool wear, machine tool vibration, damaged machine elements, etc., than as a measure of the performance of the component. There are many reasons that contribute to this tendency: average roughness remains so easy to calculate, it is well understood, and vast amount of published literature explains it, and historical part data is based upon it. It has been seen that Ra, typically, proves too general to describe surface’s true functional nature. Additionally, the push for complex geometry, coupled with the emerging technological advances in establishing new limits in manufacturing tolerances and better understanding of the tribological phenomena, implies the need for surface characterization to correlate surface quality with desirable function of the surface. In turn, the surface quality over the entire area, not just the 2D Ra parameter, dictates the performance and reliability of the part. Both ISO and ASME current standards on surface texture have a range of 3D surface quality parameters. This is further aided by the availability of modern equipment to accurately measure them. Despite these advances, design and quality professionals continue to specify surface finish based solely on the value of Ra. The same outlook trails in graduate and undergraduate education and their textbooks. This article explores how these multitudes of 2D and 3D surface quality parameters are to be understood in the design and development of high performance surfaces, and the strong need for them to be incorporated into graduate undergraduate engineering curriculum, and be taught as an improved toolkit to the aspiring engineers, process engineers and quality control professionals. Included case studies can be used to captivate the attention of the students (target audience would include industry professionals as well) and route their inquisitiveness into why they need to think beyond Ra in this era of advanced manufacturing.
|
2022-11-20T17:29:45.312Z
|
3,774,594 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1158/1078-0432.CCR-17-3055",
"MAG": "2793022348",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Purpose: Epigenetic changes are implicated in acquired resistance to platinum. Guadecitabine is a next-generation hypomethylating agent (HMA). Here, we report the clinical results, along with pharmacokinetic (PK) and pharmacodynamic analyses of the phase I study of guadecitabine and carboplatin in patients with recurrent, platinum-resistant high-grade serous ovarian cancer, primary peritoneal carcinoma (PPC), or fallopian tube cancer (FTC). Experimental Design: Guadecitabine was administered once daily on days 1 to 5 followed by carboplatin i.v. on day 8 of a 28-day cycle. Patients had either measurable or detectable disease. Safety assessments used CTCAE v4. Results: Twenty patients were enrolled and treated. Median age was 56 years (38–72 years). The median number of prior regimens was 7 (1–14). In the first cohort (N = 6), the starting doses were guadecitabine 45 mg/m2 and carboplatin AUC5. Four patients experienced dose-limiting toxicity (DLT; neutropenia and thrombocytopenia), leading to dose deescalation of guadecitabine to 30 mg/m2 and of carboplatin to AUC4. No DLTs were observed in the subsequent 14 patients. Grade ≥3 adverse events ≥10% were neutropenia, leukopenia, anemia, nausea, vomiting, ascites, constipation, hypokalemia, pulmonary embolism, small-intestinal obstruction, and thrombocytopenia. Three patients had a partial response (PR), and 6 patients had stable disease (SD) >3 months, for an overall response rate (ORR) and clinical benefit rate of 15% and 45%, respectively. LINE-1 demethylation in PBMCs and promoter demethylation/gene reexpression in paired tumor biopsies/ascites were recorded. Conclusions: Guadecitabine and carboplatin were tolerated and induced clinical responses in a heavily pretreated platinum-resistant ovarian cancer population, supporting a subsequent randomized phase II trial. Clin Cancer Res; 24(10); 2285–93. ©2018 AACR.
|
2022-12-19T05:41:12.196Z
|
1,844,439 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/j.1442-200X.2011.03420.x",
"MAG": "1587233334",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Background: Extra‐uterine growth retardation (EUGR) is associated with an increased risk for cardiometabolic diseases later in life. The aim of the present study was to examine the relationship between early weight change after birth in preterm infants and adiponectin (adn) multimeric complexes.
|
2022-12-20T04:16:57.726Z
|
14,792,724 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1093/hmg/ddp585",
"MAG": "2108070864",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://academic.oup.com/hmg/article-pdf/19/7/1153/17250205/ddp585.pdf"
}
|
The loss of HBII-52 and related C/D box small nucleolar RNA (snoRNA) expression units have been implicated as a cause for the Prader-Willi syndrome (PWS). We recently found that the C/D box snoRNA HBII-52 changes the alternative splicing of the serotonin receptor 2C pre-mRNA, which is different from the traditional C/D box snoRNA function in non-mRNA methylation. Using bioinformatic predictions and experimental verification, we identified five pre-mRNAs (DPM2, TAF1, RALGPS1, PBRM1 and CRHR1) containing alternative exons that are regulated by MBII-52, the mouse homolog of HBII-52. Analysis of a single member of the MBII-52 cluster of snoRNAs by RNase protection and northern blot analysis shows that the MBII-52 expressing unit generates shorter RNAs that originate from the full-length MBII-52 snoRNA through additional processing steps. These novel RNAs associate with hnRNPs and not with proteins associated with canonical C/D box snoRNAs. Our data indicate that not a traditional C/D box snoRNA MBII-52, but a processed version lacking the snoRNA stem is the predominant MBII-52 RNA missing in PWS. This processed snoRNA functions in alternative splice-site selection. Its substitution could be a therapeutic principle for PWS.
|
2023-01-01T17:33:05.639Z
|
240,104,016 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.53879/id.53.08.10589",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The present research work was aimed to formulate transparent mouth dissolving films of ondansetron. Ondansetron is poorly soluble in aqueous solvents (less than 5 mg/mL) and thus improvisation in solubility was crucial. The phase solubility studies were carried in order to study the formation of inclusion complex with Hydroxy Propyl Beta cyclodextrin. The phase solubility diagrams revealed the formation of stable inclusion complex and apparent stability constants were evaluated. The calculated apparent stability constant, Kc was found to be 288.5 mol-1. The shape of solubility graph indicated that there is probability of the formation of 1:1complex with respect to HP-b-CD concentration (Slope of less than 1). The Scanning Electron Microscopy study of plain ondansetron and ondansetron orodispersible film revealed the formation of stable inclusion complex, which renders the complete solubilisation of ondansetron, yielding the formation of transparent mouth dissolving films.
|
2022-01-24T18:07:57.131Z
|
112,988,132 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4028/www.scientific.net/AMM.769.312",
"MAG": "2248421135",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The hygrothermal effect is introduced by using empirical relations for degrading the material stiffness properties of the matrix. A parametric study is conducted by varying the fiber volume fraction and the fiber orientation of the angle plies in the laminate. It is possible to minimize the environmental effect by judiciously selecting the laminate configuration.
|
2022-01-27T13:39:04.966Z
|
143,291,403 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.18568/CMC.V3I8.80",
"MAG": "1884476692",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Tomando como referencia epistemologica efeitos provocados pela violencia contemporânea, discursiva e midiatizada, o artigo problematiza lugares possiveis a serem ocupados pelas teorias da comunicacao diante da violencia como fato social demarcado por incessantes processos de simbolizacao. Propoe, neste sentido, a possibilidade de uma narrativa
sobre a violencia que toma por inspiracao o principio lyotardiano da anamnese, defendendo, igualmente, sua localizacao em uma linhagem teorica ancorada no pensamento critico. Propoe, finalmente, identificar dinâmicas de consumo cultural que, no Brasil, sinalizam reapropriacoes de cenas de violencia, seja para afirma-la, seja para
contesta-la ou contrapo-la.
Palavras-chave: Violencia; comunicacao; consumo.
Abstract
Taking as an epistemological reference the effects of contemporary violence, both discursive and mediated, the article focuses on communication theories, considering among other facts the symbolic forms with which social
violence is constructed. It postulates, in this direction, the possibilityof a narrative that takes for inspiration lyotard’s principle of anamnese, defending, equally, its localization in the theoretical framework of critical theory. Finally, intends to identify some dynamics of cultural consumption
that, in Brazil, signal re-appropriations of violence scenes, either to affirm or contest it.
Keywords: Violence; communication; consumption.
|
2022-02-09T07:37:09.909Z
|
84,300,018 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1071/ea9760038",
"MAG": "2016270295",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In two experiments Merino breeding ewes were fed wheat in pens (wheat/pen) or small paddocks (wheat/paddock) from joining to weaning. Three levels of wheat were examined in each experiment (L1, M1, H1-experiment 1 ; L2, M2, H2-experiment 2) and at each wheat level a group of ewes received vitamin A. Control groups of ewes were run at pasture. The percentage of ewes pregnant in experiment 1 was higher in groups fed pasture than in groups fed wheat. There were no differences due to wheat level or vitamin A treatments. In experiment 2 there was an interaction between treatments in their effects on pregnancy rate. In experiment 2 wheat level had a linear effect on the proportion of multiple births and wheat/pen ewes gave birth to fewer twins than wheat/paddock ewes. The effects of wheat level on lamb birth weight were linear and quadratic in experiments 1 and 2 respectively. Lamb survival between birth and weaning was not influenced by wheat level or vitamin A in experiment 1. Lamb survival among groups fed wheat and pasture was 46 per cent and 84 per cent respectively. In experiment 2 there was an interaction between the treatments in lamb survival. In experiments 1 and 2, 66 per cent and 53 per cent respectively of lamb deaths among groups fed wheat were attributed to starvation. Goitre was diagnosed in 9 per cent of dead lambs from the wheat/pen groups of experiment 2. In both experiments white muscle disease was found in dead lambs from the wheat/pen groups.
|
2022-02-11T00:26:59.261Z
|
239,905,104 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1201/b22030-60",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Constitutional homeophatic medicines are used to trigger reactions in the body, reducing the susceptibility morbid, while organotherapics medicines have as a principle biological identity restoring function through the homologous healthy. Aim: evaluate the effect of the constitutional medicine Lycopodium clavatum association with organotherapics of the spleen and heart of healthy mice on parasitological and clinical aspects of murine infection by Trypanosoma cruzi. Infected mices (1400 tripomastigotes-strain-Y T. cruzi) was formed according to treatment: GLB (L. clavatum and spleen’s organotherapic 13c) n=10; GLC (L. clavatum and heart’s organotherapic 13c) n=10; GLBC (L. clavatum, spleen and heart’s organotherapics 13c) n=11; GCI (7% hydroalcoholic solution, vehicle of preparation of the medicines), n=11. The total parasitaemia was significantly lower in GLBC and GLC than GCI (p<0,05). GLBC presented smaller parasitic peak than all the groups and highest pre-patent period in relation to the GCI (p<0,05). GLBC and GLB had higher temperature and body weight in relation to GCI throughout the infection (p<0,05). The increase in feed intake was significantly higher only in GLBC compared to GCI at the end of the patent period (p<0,05), showing a healthier state than the other groups. The results suggest that the associations of constitutional medicine to organotherapic made from heart and spleen, decrease the morbidity of the infection, with clinical improvement by reducing parasitism in mice infected with the Y strain of T. cruzi, which is highly pathogenic. The results encourage the use of homeopathic medicines in the treatment of Chagas' disease. * Autor Correspondente: gisajanaina@hotmail.com (G. J. Falkowski-Temporini) G. J. Falkowski-Temporini et al./ Vittalle v. 30, n. 1 (2018) 36-45
|
2022-07-09T10:30:36.349Z
|
137,326,164 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4028/www.scientific.net/KEM.353-358.138",
"MAG": "2058506145",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Fatigue crack growth (FCG) tests have been performed in an X70 steel with various microstructures (respectively in the as-received and the normalized condition). The effect of room temperature creep (RTC) on FCG behavior has been investigated by comparing with single wave overloads (SWOL). The as-received X70 pipeline steel has high FCG rate at the near-threshold region. While at the Paris region, FCG rate seems insensitive to the microstructure. In both conditions, time-dependent deformation is observed at crack tips (i.e., RTC), which increases with increasing stress-intensity-factor. And this deformation has a high value in the normalized state, under identical testing conditions. Both RTC and SWOL can bring subsequent fatigue crack growth a very short initial acceleration before deceleration, whereas the former induces more serious deceleration and retardation, which attributes to more significant crack closures.
|
2022-09-07T06:05:31.939Z
|
109,020,327 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2514/6.1991-2659",
"MAG": "1983468294",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The paper presents a guidance scheme and several optimal reentry trajectories for a HERMES type reentry vehicle from a low-earth orbit mission to a landing site in Southern France. The guidance scheme is an extension of the guidance principles employed by the U.S. Space Shuttle. In particular, the range-control by linearization is replaced by an on-line optimization using the full nonlinear dynamics with a low parameterization for the velocity dependent drag-profile.
|
2022-09-09T01:21:43.213Z
|
102,938,897 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1021/ACS.ENERGYFUELS.7B00999",
"MAG": "2724401477",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Microbial remediation of fracturing fluid damage is for the first time to be presented in this paper. One guar gum degrading bacterial strain, Bacillus sonorensis, numbered by XSJ, was isolated from oilfield produced water and identified through 16S rDNA. The characterizations show that strain XSJ is mesophilic, alkalophilic, facultative, and halophilic, which is suitable for the reservoir environment. In addition, the guar gum degrading performance of this strain was investigated through apparent viscosity of the guar gum solution, the average molecular weight of guar gum, and gas chromatography. Besides, the degrading performance of insoluble residue of guar gum was analyzed through the measurement of particle size distribution using a laser particle size analyzer and total weight of insoluble residue using a weighing method. Finally, a kind of sand-pack column was designed to determine the recovery of permeability. The results indicate the following: (1) Bacillus sonorensis can efficiently degrade guar...
|
2022-11-24T16:54:18.084Z
|
59,335,351 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.22038/EBCJ.2016.7195",
"MAG": "2512699385",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Background: As two of the most prominent cultural components, spirituality and religion give sense to our human values, conducts, and experiences. The spiritual dimension is one of the four significant aspects of holistic care. However, the diversity of views has resulted in different interpretations of the reality of spirituality and its origins and consequences. Aim: This study aimed to examine the available approaches and paradigms in the realm of spirituality. Method: In the present integrative review, the initial search was performed in national and international databases, including Science Direct, PubMed, Google Scholar, Scopus, Sage, Medline, Wiley, SID, MagIran, IranMedex, and IranDoc, using the keyword, "spirituality", without considering any time limits. Articles relevant to the objectives of the study were then fully reviewed. Results: Since ancient times, spirituality has been sporadically discussed in human intellectual and artistic artifacts. This concept was expanded as an independent, systematic, and conscious movement since the second half of the 19th century in Europe, USA, and Canada. The three prominent approaches to spirituality include religious, secular, and holistic health perspectives. Implications for Practice: Despite the growing interest in research on spirituality, it is difficult to reach a unanimous decision about this concept. However, it should be noted that spiritual concerns cannot be disregarded, considering the holistic perspective to humanity as the building block of holistic nursing care. Overall, every patient is a unique human being whose spiritual needs are affected by his/her cultural beliefs and values.
|
2022-12-17T23:24:48.691Z
|
212,584,480 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.15761/nfo.1000119",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.oatext.com/pdf/NFO-2-119.pdf"
}
|
Change in levels of vascular endothelial growth factors (VEGF) isoforms is a feature of diabetic retinopathy. To better characterize the expression of VEGFa and VEGF165b isoforms in the diabetic retina and to explore how oxidative stress influences the balance between these molecules, we have used the Ins2Akita mouse model of diabetes. Retinal tissue collected from wild-type and Ins2Akita mice, together with D407 retinal pigment epithelial (RPE) cells were used as experimental models. The retina of the Ins2Akita diabetic mice was shown to have decreased levels of the anti-angiogenic VEGF165b protein and a high production of reactive oxygen species (ROS). High glucose deregulated the expression of VEGF proteins as well as the production of ROS in RPE cells. Physiological levels of H2O2 were found to preserve the equilibrium between VEGF isoforms in RPE cells while pathological levels down-regulated the VEGF165b. Besides hyperglycemia, oxidative stress also contributes to disrupt the equilibrium between proand anti-angiogenic factors in the retina, a profile frequently found in retinal pathologies. Abbreviations: AMD – age-related macular degeneration; BRB – blood-retinal barrier; DR – diabetic retinopathy; PEDF – pigment epithelium-derived; factor RPE – retinal pigment epithelial; ROS – reactive oxygen species; VEGF – vascular endothelial growth factor
|
2022-12-30T00:41:24.109Z
|
35,946,727 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/ICIP.1999.817295",
"MAG": "2105206720",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
We propose a technique for the real-time synthesis of temporally interpolated video frames suitable for low bandwidth applications. The system is based on the warping of edge preserving meshes. Node selection segments the scene and places mesh nodes on top of object edges in the reference frame. Constrained Delaunay triangulation is used to create a mesh that keeps triangulation edges aligned with object edges in the scene. Node displacements are estimated and several interpolated frames may be synthesized between each pair of original frames without the need for fitting a new mesh to the reference frame. Each of the interpolated frames is synthesized by warping the mesh. We present experimental results that demonstrate the performance and applicability of the proposed method.
|
2022-01-27T10:53:32.732Z
|
226,202,588 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.15690/RPJ.V1I2.2088",
"MAG": "3024624147",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Background . Congenital heart defects (CHD) are the most common type of developmental anomalies in children. At present the early diagnosis of congestive heart failure (CHF) and CHF-associated pathologic conditions is becoming increasingly important for optimization of protocols for following up pediatric patients in the primary health care settings. Objective . The study aimed at determining the prognostic role of brain natriuretic peptide (BNP) as a diagnostic marker of CHF progression and development of CHF-associated pathological conditions in babies with CHD during the first year of life. Methods . A prospective cohort study was carried out in a total of 114 children of the first year of life. The main study group was comprised of 61 children with confirmed diagnosis of CHD, and the control group of 53 health status group I–IIA children without CHD. Results . Diagnostic role of BNP elevation > 30 pg/mL was determined. At this BNP level the risk for developing stage 2A CHF increased 7-fold (OR 7.5 [1.8–31.5]), for developing functional class (FC) 2 CHF — nearly 5-fold (OR 4.6 [1.3–16.0]), and for FC 3 CHF such risk increased 9-fold (OR 9.2 [2.3–36.1]). Our results demonstrated that the BNP level measurements can be used in clinical practice to determine the likelihood of persistence of symptoms of perinatal CNS injuries during the first year of life (OR 7.6 [1.7–34.5]) and protein and energy deficit (PED) (OR 9.5 [2.5–35.5]) in children with CHD.
|
2022-06-14T03:28:23.130Z
|
250,941,061 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.51522/2307-0382-2022-237-2-55-61",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
В настоящее время важным для осуществления исправительного процесса в местах ли-шения свободы является изучение особенностей личности осужденных как важнейшей предпосылкииндивидуализации карательных и воспитательных воздействий, повышения их эффективности.Цель исследования – изучение особенностей личности осужденных женского пола, впервые отбыва-ющих наказание за насильственные преступления в исправительной колонии.Научная и практическая значимость работы заключается в том, что при использовании модифи-цированной методики «Подростки о родителях» (ПоР, ADOR) была отмечена негативная тенденция вметодах и стиле воспитания в родительской семье осужденных женщин, что могло оказать влияние настремление к нарушению норм и правил и повлечь за собой совершение противоправных действий.Методология исследования базируется на фундаментальных и прикладных работах пенитенциар-ных психологов и педагогов.В ходе исследования была представлена характеристика осужденных женского пола, впервые от-бывающих наказание за преступления насильственного характера, которую необходимо учитыватьпри осуществлении исправительного процесса в условиях лишения свободы.Результаты исследования можно использовать при разработке научно обоснованной программыпсихокоррекционной работы, направленной на повышение эффективности мероприятий ресоциали-зирующего характера и понижения уровня рецидива.
At present, it is important for the implementation of the correctional process in places ofdeprivation of liberty to study convicts’ personality characteristics as the most important prerequisite forthe individualization of punitive and educational influence, increasing the effectiveness of the latter for thecorrectional process implementation in places of deprivation of liberty. The aim of the research is to studypersonality traits of female convicts serving their sentences for violent crimes in a correctional colony forthe first time. Scientific and practical significance of the work lies in the fact that while using the modifiedmethodology "Teenagers about Parents" (POR, ADOR), a negative trend in methods and style of upbringingin the parental family of convicted women has been noted, that might have an impact on the desire to violatenorms and rules and give rise to unlawful acts. The research methodology is based on psychologists’ andeducators’ fundamental and applied penitentiary works. The study has presented the characteristics ofconvicted females serving sentences for crimes of a violent nature for the first time and which must be takeninto account when implementing the correctional process in conditions of deprivation of liberty. The results ofthe study can be used in the development of a scientifically based program of psychocorrectional work aimedat increasing the effectiveness of resocializing measures and reducing the level of reoffending.
|
2022-07-23T15:48:37.248Z
|
1,248,522 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/ANA.410430123",
"MAG": "1992067926",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In inclusion body myositis, T cells invade and destroy nonnecrotic muscle fibers. The mechanism by which T cells damage muscle fibers in inflammatory myopathies is not known. In this study we have investigated the expression of Fas and Fas ligand in muscle in five patients with inclusion body myositis. Reverse transcription polymerase chain reaction showed upregulation of both Fas and Fas ligand in all inclusion body myositis patients. Immunohistochemical investigation showed expression of Fas ligand in many of the muscle infiltrating mononuclear cells. Fas was expressed both in mononuclear cells and on the surface of muscle fibers in inclusion body myositis patients and in patients with polymyositis but not in patients with Duchenne muscular dystrophy or denervation. The results indicate that the Fas/Fas ligand system may be of importance for the inflammatory reaction and T‐cell–mediated muscle cell injury.
|
2022-09-30T17:27:53.894Z
|
583,045 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1159/000362883",
"MAG": "1973395878",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Background: In general, it seems that both genetic and environmental factors play important roles in the induction of neural tube defects. Lipomyelomeningocele (LipoMMC) is a rather common type of closed neural tube defect, but only limited studies have investigated the potential risk factors of this anomaly. Therefore, the purpose of this case-control study was to investigate the risk factors involved in LipoMMC formation. Material and Method: Various risk factors were evaluated in 35 children between 1 month and 10 years of age with LipoMMC in a hospital-based case-control study. The 2 control arms consisted of 35 children with myelomeningocele (MMC group) and 35 children with congenital anomalies other than central nervous system problems (control group). All groups were matched for age and visited the same hospital. A structured questionnaire was used for the collection of all data, including the mothers' weight and height during pregnancy, education, reproductive history, previous abortions, and socioeconomic status, as well as the parents' consanguinity and family history of the same anomalies. Results: Univariate analysis of the children with LipoMMC compared to the control group showed that the use of periconceptional folic acid supplementation was significantly lower in the MMC and LipoMMC groups compared to the control group. In addition, comparison of the MMC and control groups revealed statistically significant differences regarding the use of folic acid and maternal obesity. In multivariate analysis, use of folic acid in the periconceptional period and during the first trimester was an independent risk factor for LipoMMC and MMC. Furthermore, maternal obesity was a significantly positive risk factor for MMC. Conclusion: The probable risk factors for LipoMMC were investigated in this case-control study. Consumption of folic acid in the periconceptional period and during the first trimester is an independent protective factor against LipoMMC. It seems that larger studies are needed to examine other possible risk factors.
|
2022-12-11T03:38:22.480Z
|
37,862,207 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1001/ARCHPSYC.60.5.490",
"MAG": "2158422476",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
BACKGROUND
Certain aspects of the personality may be associated with the vulnerability to develop depression. A sib-pair method has been used to examine the familiality of the 7 scales of the Temperament and Character Inventory (TCI) and whether this could be related to the genetic vulnerability to develop depression.
METHODS
Probands with depression and their nearest-aged siblings from Wales were compared with healthy control probands and their nearest-aged siblings on the TCI and measures of depressed mood.
RESULTS
All 7 scales of the TCI were familial, and scores on 6 of the scales were similar to US population scores. However, the Welsh subjects' scores on the self-transcendence scale were markedly lower than the US mean, suggesting strong cultural or national influences on this measure. Harm avoidance scores were substantially influenced by current and past depression, but this scale also showed stable traitlike characteristics that are likely related to the genetic vulnerability to depression. Novelty seeking and self-directedness were also partly state-dependent and were negatively correlated with low mood; high scorers may be resilient to the development of depression. High reward dependence may also protect against the development of depression and is unrelated to mood state. The cooperativeness, persistence, and self-transcendence scales appear to have a limited relationship with the development of depression.
CONCLUSIONS
Harm avoidance, reward dependence, novelty seeking, and self-directedness have traitlike characteristics that are related to the familiality of depression. Cooperativeness, self-transcendence, and persistence are also familial, but this appears to be unrelated to depression.
|
2022-12-21T01:29:43.706Z
|
156,397,654 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2307/1055013",
"MAG": "2332506309",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Depending on one's purpose, the term "Southern Agriculture" may signify different geographic areas. As used in this paper the Old Cotton South, includes eight States-the Carolinas, Alabama, Georgia, Tennessee, Mississippi, Arkansas, and Louisiana. This is not a homogeneous area. Had data permitted, the Old South would have been delineated along more homogeneous lines. But the region selected does have common problems, and it is from this standpoint that the long-term prospects of its agriculture are considered.
|
2022-02-09T00:48:35.004Z
|
98,202,054 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1021/ED041P458",
"MAG": "2091152286",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Ignatius Martinovics suffered the same fate as Lavoisier, but for very different political reasons.
|
2022-02-10T12:54:23.534Z
|
238,137,263 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.18272/post(s).v6i1.2072",
"MAG": "3186160351",
"PubMedCentral": null
},
"license": "CCBYNCSA",
"status": "GOLD",
"url": "https://revistas.usfq.edu.ec/index.php/posts/article/download/2072/2146"
}
|
Healing Through Remembering es una serie fotográfica en la que Eli Farinango emprende un viaje de sanación y encuentro con sus ancestros. Es una historia íntima que se teje entre las conversaciones con sus abuelas, entre emociones y dolor. La familia de Eli migró a Canadá cuando ella tenía nueve años. Eli creció entre idas y venidas, a medio camino siempre entre pertenecer y no pertenecer. En este trabajo, escuchamos a Eli conversar con ella misma, con los suyos y con nosotrxs. La vemos buscarse y encontrarse en tres lenguas, en distintos territorios y siempre en ella.
|
2022-06-18T12:42:54.352Z
|
200,050,761 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.18820/23099089/ACTAT.SUP27.8",
"MAG": "2964087587",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The unemployment crisis is a growing threat in the socio-economic fabric of South African society. Close to fifteen million people live on social grants, while seven million are registered as unemployed. The number is growing exponentially. High-school leavers and university graduates have no assurance of employment at the end of their academic careers. The church, in general, is bombarded by demands of these masses for survival. The number of beggars at the urban church doors increases daily. In the meantime, the church is, in a broader context, silent or passive towards the voices of the unemployed. There is not only deafening silence, but also no plans, strategies, or initiatives to launch projects that can assist in minimising unemployment in society. However, acknowledgement is attested to many churches undertaking some programmes to address this threat. The unemployed feel marginalised. They are robbed of their dignity through short-term interventions instead of proactive initiatives that can make them employable 1 In this instance, the word “church” is used in two senses. First, in a general sense, to refer to a particular body of faithful people, and the whole body of the faithful. Secondly, as a reference to “assembly, congregation, council”, or “convocation” in a specific geographical setting. The epitaph is always visible at the entrance to the building where the second sense of the word applies. K.T. Resane Dr. K.T. Resane, Research fellow, Department of Historical and Constructive Theology, University of the Free State, South Africa. E-mail: resanekt@ufs. ac.za. ORCID: https://orcid. org/0000-0002-45024933 DOI: http://dx.doi. org/10.18820/23099089/ actat.Sup27.8 ISSN 1015-8758 (Print) ISSN 2309-9089 (Online) Acta Theologica 2019 39(1):132-147
|
2022-07-07T11:30:47.497Z
|
250,893,058 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1088/0256-307X/17/5/016",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Several envelope soliton fine structures have been observed in solar radio metric-wave emission. We present a model of longitudinal modulational instability to explain these fine structures. It is found that this instability can only occur in the condition of sound velocity being larger than Alfvén velocity in corona. Therefore, the envelope soliton fine structures should display in the coronal region with high temperature and low magnetic field, which corresponds to the solar radio emission in the region of meter and decameter wavelength.
|
2022-07-31T03:30:26.706Z
|
251,324,861 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/ITAIC54216.2022.9836593",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
5G network slicing plays a key role in the smart grid business. The existing authentication schemes for 5G slicing in smart grids require high computing costs, so they are time-consuming and do not fully consider the security of authentication. Aiming at the application scenario of 5G smart grid, this paper proposes an identity-based lightweight secondary authentication scheme. Compared with other well-known methods, in the protocol interaction of this paper, both the user Ui and the grid server can authenticate each other's identities, thereby preventing illegal users from pretending to be identities. The grid user Ui and the grid server can complete the authentication process without resorting to complex bilinear mapping calculations, so the computational overhead is small. The grid user and grid server can complete the authentication process without transmitting the original identification. Therefore, this scheme has the feature of anonymous authentication. In this solution, the authentication process does not require infrastructure such as PKI, so the deployment is simple. Experimental results show that the protocol is feasible in practical applications
|
2022-08-11T18:31:08.245Z
|
229,360,932 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.21608/ttaip.2019.123732",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://ttaip.journals.ekb.eg/article_123732_42a9414853104d2dacf5a3268d81922a.pdf"
}
|
The research has a threefold literary approach with a psychological, philosophical as well as a technical perspective. It aims at examining the narrative technique used by Egyptian novelist and script writer Mohamed Rageh in A Quarter Citizen. The research seeks to show Rageh’s novel as belonging to the narrative therapy type. It suggests that following this type of therapeutic narrative, Rageh builds heavily on the Michael Foucault’s concept of ‘heterotopia’ and frame narrative technique. This could be traced in the novel’s presentation of different types of heterotopias together with a form of frame narrative exemplified in his presentation of a scriptwithina novel technique. This sets narration in Rageh’s A Quarter Citizen as starkly built on parallelism and juxtaposition. In his scenanovel, as he ventures to calls it, Rageh juxtaposes the protagonist's true experience with a different version of it rendered in the form of a script. A further type of parallel in the novel is that between different forms of 'heterotopias' especially the prison as heterotopias of deviation where the larger part of the novel's actions take place. In light of this, the research seeks to trace the extent to which narration was an aid to the novel's protagonist and how far it helped him to relieve his psychic disturbances resulted from his incarceration experience. In so doing, the research poses the question whether narration in Rageh's A Quarter Citizen proves to be therapeutic or not and if it successfully follows the two prerequisite steps of narrative therapy namely externalization and suggestion. Further questions are concerned with the therapeutic role played by the script/ heterotopia and the models of identity building suggested by the script.
|
2022-08-20T10:40:18.359Z
|
23,171,013 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4012/DMJ.2011-137",
"MAG": "2000048157",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The purpose of this study was to evaluate the influence of flexural modulus of non-metal posts on the fracture strength and failure mode of composite resin cores. Thirty-two human premolars were divided into four groups: prefabricated glass fiber post with 1.0 mm diameter and composite resin core (Group PE1.0), that with 1.5 mm diameter and composite resin core (Group PE1.5), experimental post (flexural modulus; 4.25GPa) and composite resin core (Group EX), and preparation for abutment teeth only (Group NT). After a static loading test, the fracture strength and failure mode were recorded. Group NT (1670.81 N) showed higher fracture strength than Groups PE1.0 (866.44 N), PE1.5 (825.19 N) and EX (1075.63 N) (p<0.05). This study showed that the fracture strength of endodontically treated teeth restored with composite resin cores is not influenced by the flexural modulus of non-metal posts.
|
2022-08-24T18:10:37.835Z
|
221,721,819 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1097/CM9.0000000000001072",
"MAG": "3086546459",
"PubMedCentral": "7575175"
},
"license": null,
"status": null,
"url": null
}
|
Abstract Background: Epithelial to mesenchymal transition (EMT) is strongly linked with tumor invasion and metastasis, which performs a vital role in carcinogenesis and cancer progression. Emerging evidence suggests that microRNAs (miRNAs) expression are closely associated to EMT by regulating targeted genes. MiR542 has been found to be involved in the EMT program and bound up with various cancers. However, the functions of miR542 and its underlying mechanism in glioblastoma multiforme (GBM) remain largely unknown. In the current study, we investigated the effect of astrocyte elevated gene-1 (AEG-1) on U251 cells aggressiveness, proliferation, apoptosis, and cell cycle. Methods: The screening of targeted miRNAs was performed, as well as the functional roles and mechanisms of miR542 were explored. Results: MiR542 was selected as the target because of the most significantly differential expression and this high level of expression negatively correlated with cell migration and proliferation, which suggested that miR542 could be a novel tumor suppressor. Moreover, we confirmed that AEG-1 was a direct targeted gene of miR542 by luciferase activity assay, reverse transcription-polymerase chain reaction, and immunoblotting analysis. Furthermore, miR542 suppressed the expression of AEG-1, which upgraded the level of E-cadherin and degraded Vimentin expression contributing to retraining EMT. Conclusion: The in vitro findings demonstrated that miR542 inhibited the migration and proliferation of U251 cells and suppressed EMT through targeting AEG-1, indicating that miR542 may be a potential anti-cancer target for GBM.
|
2022-09-08T20:45:58.392Z
|
46,931,250 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4172/2161-0673.1000201",
"MAG": "2796739045",
"PubMedCentral": null
},
"license": "CCBY",
"status": "HYBRID",
"url": "https://doi.org/10.4172/2161-0673.1000201"
}
|
A percutaneous electrogastrogram (EGG) is a simple and low-restraint way to measure the electrical activity of the gastrointestinal tract. An electrogastrogram examination is a noninvasive method of evaluating gastrointestinal motility and autonomic nervous system activity. However, EGGs are not as widely used in clinical settings as electrocardiograms (ECGs) or electroencephalographs (EEGs) because an EGG can be impacted by electrical activity from the myocardium and the diaphragm (due to respiration), and there is no method to relate the functions of the stomach to the data obtained. This paper examines the effect of exercise on gastric electrical activity using two exercise intensities to confirm the basic biological response of an EGG. It was found that, after high-intensity exercising, the spectrum density at the normal frequency band of the stomach (2.4-3.7 cpm) decreased, which may indicate a decline in gastric activity taking place during exercise. Moreover, after high-intensity exercise, translation error increased significantly. Exercise intensity is thought to affect the electrical activity of not only the gastrointestinal tract, but also of other organs.
|
2022-10-19T16:32:47.349Z
|
13,069 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1145/1824801.1824805",
"MAG": "2039917338",
"PubMedCentral": null
},
"license": "pd",
"status": "GREEN",
"url": "https://digital.library.unt.edu/ark:/67531/metadc899585/m2/1/high_res_d/941539.pdf"
}
|
The Thick-Restart Lanczos (TRLan) method is an effective method for solving large-scale Hermitian eigenvalue problems. The performance of the method strongly depends on the dimension of the projection subspace used at each restart. In this article, we propose an objective function to quantify the effectiveness of the selection of subspace dimension, and then introduce an adaptive scheme to dynamically select the dimension to optimize the performance. We have developed an open-source software package a--TRLan to include this adaptive scheme in the TRLan method. When applied to calculate the electronic structure of quantum dots, a--TRLan runs up to 2.3x faster than a state-of-the-art preconditioned conjugate gradient eigensolver.
|
2022-12-14T06:05:54.236Z
|
39,077,973 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/CQR.2009.5137352",
"MAG": "2146441187",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
As the industry moves to more mature software processes (e.g., CMMI) there is increased need to adopt more rigorous, sophisticated (i.e., quantitative) metrics. While quantitative product readiness criteria are often used for business cases and related areas, software readiness is often assessed more subjectively & qualitatively. Quite often there is no explicit linkage to original performance and reliability requirements for the software. The criteria are primarily process-oriented (versus product oriented) and/or subjective. Such an approach to deciding software readiness increases the risk of poor field performance and unhappy customers. Unfortunately, creating meaningful and useful quantitative in-process metrics for software development has been notoriously difficult.
|
2022-12-17T13:02:57.020Z
|
252,778,720 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/hep4.2111",
"MAG": null,
"PubMedCentral": "9701460"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hep4.2111"
}
|
To the editor: We appreciate the interest garnered by the article “Heterologous adenovirusvector/messenger RNA regimen is associated with improved severe acute respiratory syndrome coronavirus 2 humoral response in liver transplant recipients.” The comments by Dr. Sookaromdee and Dr. Wiwanitkit highlighted the importance of assessing prior severe acute respiratory syndrome coronavirus 2 (SARSCoV2) infection when testing antibody response to SARSCoV2 vaccination. This observation is relevant given that patients who recovered from corona virus disease 2019 (Covid19) present detectable prevaccination antispike immunoglobulin G titers, even liver transplant recipients.[1] Moreover, after receiving a complete vaccination scheme, the antibody titer can significantly increase compared to patients naive for Covid19.[1,2] However, to avoid this bias and consequently misinterpret the effect of vaccination, in our study population, we excluded patients with prior infection confirmed by polymerase chain reaction. Likewise, as detailed in the methods section, before patients' inclusion, antibodies toward the nucleocapsid (N) protein were analyzed by chemiluminescence assay (ALINITY SARSCOV2 IGG; Abbott) in a certified biochemistry testing laboratory to estimate past SARSCoV2 infection. In summary, we are satisfied with these discussions and interactions, which enrich our study, and we trust that our results will be a key tool for both conventional clinical practices as well as future research.
|
2022-12-21T19:37:56.638Z
|
49,589,512 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/hbm.24286",
"MAG": "2811045939",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hbm.24286"
}
|
Excessive internet use is shown to be cross sectionally associated with lower cognitive functioning and reduced volume of several brain areas. However, the effects of daily internet use on the development of verbal intelligence and brain structures have not been investigated. Here, we cross sectionally examined the effects of the frequency of internet use on regional gray/white matter volume (rGMV/rWMV) and verbal intelligence as well as their longitudinal changes after 3.0 ± 0.3 (standard deviation) years in a large sample of children recruited from the general population (mean age, 11.2 ± 3.1 years; range, 5.7–18.4 years). Although there were no significant associations in cross sectional analyses, a higher frequency of internet use was found to be associated with decrease of verbal intelligence and smaller increase in rGMV and rWMV of widespread brain areas after a few years in longitudinal analyses. These areas involve areas related to language processing, attention and executive functions, emotion, and reward. In conclusion, frequent internet use is directly or indirectly associated with decrease of verbal intelligence and development to smaller gray matter volume at later stages.
|
2022-12-30T00:21:42.468Z
|
252,770,030 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5582/irdr.2022.01079",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": "GOLD",
"url": "https://www.jstage.jst.go.jp/article/irdr/11/4/11_2022.01079/_pdf"
}
|
Rare diseases (RDs) affect up to 8% of the world's population, and unfortunately, health professionals have a low level of knowledge regarding the impacts of RDs on the social, psychological, and economic spheres of the patients and their families; hence, RD management is inadequate, consistently empirical, and precarious. The objective of this study was to determine the knowledge level of the medical students from a non-state university and physicians from Lima, Peru of RDs through a virtual survey for an analytical cross-sectional study. A total of 338 medical students and 382 physicians were surveyed. Results showed that several of the respondents (68.1% of students and 48.7% of physicians) had heard of the term "rare disease", but only a few stated that they had received any kind of training specific to it. Of the physicians, 46.6% considered that there should be a course about RDs in medical curricula, and more than 60% considered RDs a public health problem. Most respondents prioritized the planning of a higher budget for common diseases and believe it is convenient to allocate a specific fund for RDs. More than half of the participants had a very poor knowledge level. Due to students and physicians' low level of general knowledge of RDs, it is important to raise awareness and improve their education about these pathologies because this will have beneficial effects for RD patient care.
|
2022-12-16T14:41:49.921Z
|
135,907,367 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4028/www.scientific.net/AMR.163-167.1485",
"MAG": "1999264065",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In the three kinds of constraint ratio (ξ = 0.065, ξ= 0.1025, ξ= 0.205), respectively, by the comparative analysis of 55 prism specimens using CFRP confined concrete(strain ratses are 10-5/s-1, 10-4/s-1, 10-3/s-1 and 10-2/s-1), the stress-strain curves, strength, strain, elastic modulus and Poisson's ratio were studied at different constraints and different strain rate. The results show that: (1) with the strain rate increased,the inflexion strength and ultimate strength of concrete were improved; (2) with the strain rate increased, the static and dynamic elastic modulus increased slightly; (3) Poisson's ratio increased slightly with the growth strain rate.
|
2022-02-09T11:24:21.764Z
|
238,474,813 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3760/cma.j.cn112144-20210508-00218",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Objective: To assess the longitudinal changes in oral health-related quality of life (OHRQoL) and the denture satisfaction of immediate rehabilitation by implant-supported full-arch prostheses in patients of the edentulous and potential edentulous jaws. Methods: Patients in the Department of Implantology, Peking University School and Hospital of Stomatology from April 2008 to November 2020 were enrolled in the study. The treatment group (TG) consisted of 73 patients who had been treated with immediate rehabilitation by using implant-supported full-arch prostheses while the control group (CG) consisted of 31 patients who would be treated with immediate rehabilitation of implant-supported full-arch prostheses. The mean age of the patients in the treatment group was (57.5±11.1) years (ranged 31-79) and the average follow-up duration was 5.5±2.9 years (ranged 1-12). The OHRQL ratings were collected using oral health impact profile-20 (OHIP-20) and the visual analogue scales (VAS) was used to assess the denture satisfaction including stability, aesthetics, mastication, ease of cleaning, speaking and general satisfaction. Independent t-test, Mann-Whitney U-test and locally weighted scatterplot smoothing were applied for data analysis. Results: The cumulative survival rate (CSR) of the implants was 97.6% (450/461). The CSR of the prostheses was 93.3% (98/105). The average peri-implant marginal bone loss (MBL) was (0.8±0.4) mm and (1.2±0.6) mm after 1 and 5 years, respectively. The mean OHIP-20 total scores of TG and CG were 5(7) and 32.9±12.6, respectively, which had statistical difference between the two groups (P<0.001). The general satisfaction in the TG was 95.0(10.0), while the higher scores were for chewing [100.0(7.5)] stability [100.0(10.0)] and esthetics [100.0(10.0)] and the lower scores were for ease of cleaning [85.0(25.0)] and speaking ability [100.0(12.5)]. With prolonged follow-up, the total OHIP-20 score decreased significantly at first and then remained stable with minor fluctuations. Conclusions: Based on the present study, immediate rehabilitation with implant-supported full-arch prostheses was a feasible treatment program that had a long-term positive impact on OHRQoL, provided strong psychological and sociological support to the patients and restored the chewing and speech functions effectively.
|
2022-02-07T20:32:08.446Z
|
146,891,197 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.12731/2218-7405-2015-11-64",
"MAG": "2301818603",
"PubMedCentral": null
},
"license": "CCBYNCND",
"status": "GOLD",
"url": "https://doi.org/10.12731/2218-7405-2015-11-64"
}
|
В статье, в целях успешного формирования и развития интеллекта будущих офицеров внутренних войск МВД России, проведен системный анализ различных научных источников, посвященных исследованию проблемы педагогических условий формирования и развития различных качеств личности в педагогическом процессе. Авторы обосновывают актуальность проведения такой работы, рассматривают полученные результаты, приводят мнения различных авторов по данному вопросу. На основе представленных данных сделаны соответствующие выводы. Полученные авторами научные результаты можно использовать в образовательной практике военного вуза. Ключевые слова: интеллект; интеллектуальные способности; интеллектуальная
|
2022-04-08T01:08:12.568Z
|
144,981,540 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/02687038.2013.793283",
"MAG": "2056135265",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Background: Anomia is often one of the earliest signs of Alzheimer disease (AD), and progressive language impairment remains a major source of disability throughout the disease course. Aims: This article reviews the potential uses of pharmacological adjuvants to augment neuroplasticity during speech and language therapy. Main Contribution: We begin with a discussion of the nature of anomia in AD from the perspective of classical aphasia models and in terms of a parallel distributed processing model of language. Physiological functions of acetylcholine, norepinephrine and dopamine are reviewed. We consider how pharmacological manipulation of these neurotransmitters in combination with speech and language therapy has the potential to promote maintenance and restoration of the functional connectivity within the lexical, semantic and phonological networks that are the basis of propositional language. Conclusions: AD is a disease of synaptic loss. People with AD are able to reacquire knowledge, and pharmacological modulation of acetylcholine, norepinephrine and dopamine can influence the maintenance and reformation of neuronal networks.
|
2022-07-02T06:03:01.810Z
|
114,279,881 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.17533/UDEA.REDIN.N77A18",
"MAG": "2370132163",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In order to obtain the envelope curve of shear force and bending moment induced by vehicle live loads along Mexican isostatic bridges with spans from 15.0 to 50.0 m, fi rst and second-degree equations are calculated by considering the position from the initial right joint to the fi nal left joint of a beam as the independent variable. Additional to the professional use of this elementary tool, it can be used in academic courses of bridge design in order to avoid the illegal use of commercial software. By using a simple-short algorithm developed in a free software application, the theoretical envelope curves are obtained. In order to simplify the process, these curves are used to calculate the coeffi cients of shear force and bending moment equations by means of a statistical analysis. The minimum value of correlation coeffi cient for both methodologies was 0.98. This proposed method could be also extended to other vehicle loads used worldwide.
|
2022-07-10T22:30:57.566Z
|
250,932,582 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.23919/ascc56756.2022.9828275",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Distributed filtering problem with event-based transmissions and uncorrelated additive noises has been extensively studied in the literature. However, in many practical applications, the sensor node measurements are corrupted with multiplicative noise along with additive noise. Furthermore, the additive noises (of the process and sensor) are also correlated. Hence, the filter’s performance may not be optimal if the above two additional conditions are not considered while designing the filter. Therefore, in this work, we consider the distributed filtering problem for a linear discrete-time system with event-based transmissions, multiplicative measurement noise, and correlated additive noises. To design an optimal distributed filter for such a system, we first derive the upper bound of the estimation error covariance matrix to show that the mean square error of the distributed filter is convergent. We then derive the filter gain matrix by minimizing the trace of the upper bound of the estimation error covariance matrix to compute the state estimates of the considered system. Finally, a numerical example is presented to validate the derived distributed filtering algorithm.
|
2022-08-06T01:12:09.373Z
|
32,521,138 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/j.1600-0536.1991.tb01825.x",
"MAG": "2023349725",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
We report a case of occupational allergic contact dermatitis from rhoidium sulphate and cobalt Chloride in a 29‐year‐old woman working in a goldsmith's workshop. the relevance and source of sensitization to these metals in our patient is described, and the literature on the subject reviewed.
|
2022-09-10T09:39:15.063Z
|
95,138,919 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2115/FIBER.58.117",
"MAG": "2005042590",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Thermal decomposition in the initial stage of Nylon 66 carpets and their components was analyzed by thermogravimetry (TG), and TG-Fourier transform infrared spectrometry (TG-FTIR). The Ozawa-Flynn-Wall method was applied in the initial stage of thermal decomposition. It was found that the thermal stability of carpet depends on the characteristics of backing materials. Poly(vinyl chloride) (PVC) backing is easily decomposed and mass residues was high due to the presence of additives. HCl gas was evolved from PVC backing in a temperature ranging from 300 to 400 °C where, in contrast, a-olefin backing showed stable performance.
|
2022-12-02T18:38:42.047Z
|
56,487,148 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1515/icom-2018-0023",
"MAG": "2900816027",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Abstract What will future creativity-based work in collaboration with ubiquitous, AI-driven systems be like? In this paper, we argue that following a ‘tangible interaction’ approach can be beneficial in this context. We describe six connected objects that illustrate how the quality of future creative work could be designed. The objects aim to shape embedded computation in ways that support embodied interaction. They include a place for sacrificing one’s phone, an olfactory calendar, a reader/writer for cloud data in everyday objects, a concrete-based data logger, a slot machine for recombining old ideas into new ones, and a dimmer for artificial intelligence. We summarize the results of a critical reflection of the prototypes in an argument for designing interactions that foster collaborative creative processes between embodied humans in a world of embedded computation.
|
2022-02-11T19:14:19.250Z
|
245,480,701 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/pde.14842",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Swimmers often complain of dry skin, consistent with decreased skin sebum levels, and yet may also have acne, which is commonly related to elevated sebum levels. Sixteen adolescent swimmers with and without acne were enrolled to examine two markers of facial sebum levels before and after 1 hour of swimming. Swimmers with acne did not have significant decreases in their sebum levels or shine measurements after swimming, whereas swimmers without acne did. Overall, swimming may remove superficial sebum more than follicular sebum and therefore leave swimmers subject to both dry skin and acne simultaneously.
|
2022-07-11T03:51:58.760Z
|
31,947,705 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/j.1463-1318.2007.01306.x",
"MAG": "1964463923",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Objective This study was undertaken to determine the relationship between epidermal growth factor receptor (EGFR) status in primary colorectal cancer (CRC) to different clinico‐pathological prognostic factors.
|
2022-09-05T02:42:31.318Z
|
8,584,452 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1145/1836845.1836926",
"MAG": "2023705399",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
It is known that a high dynamic range (HDR) image can be produced by sequentially capturing a set of low dynamic range (LDR) images with different exposure times [Debevec and Malik 1997]. However, ghosting artifacts could be produced via this method when there are moving objects in a scene. In this poster, a similarity index is first introduced for such LDR images by using intensity mapping functions (IMFs) among them. The index is then applied to detect moving objects such that ghosting artifacts are removed from the eventual HDR image. The details are given as below.
|
2022-09-15T06:18:46.169Z
|
22,841,316 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1121/1.2902167",
"MAG": "1984352330",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Pathologic changes within the organic constitution of vocal folds or a functional impairment of the larynx may result in disturbed or even irregular vocal fold vibrations. The consequences are perturbations of the acoustic speech signal which are perceived as a hoarse voice. By means of appropriate image processing techniques, the vocal fold dynamics are extracted from digital high-speed videos. This study addresses the approach to obtain a parametric description of the spatio-temporal characteristics of the vocal fold oscillations for the aim of classification. For this purpose a biomechanical vocal fold model is introduced. An automatic optimization procedure is developed for fitting the model dynamics to the observed vocal fold oscillations. Thus, the resulting parameter values represent a specific vibration pattern and serve as an objective quantification measure. Performance and reliability of the optimization procedure are validated with synthetically generated data sets. The high-speed videos of two normal voice subjects and six patients suffering from different voice disorders are processed. The resulting model parameters represent a rough approximation of physiological parameters along the entire vocal folds.
|
2022-12-03T18:24:51.294Z
|
152,035,794 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1353/NLH.2016.0015",
"MAG": "2523083280",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Abstract: Bruno Latour and Antoine Hennion have been travelling companions for a long time. In order to discuss concretely the possible relationship between the humanities and Latour’s An Inquiry into Modes of Existence, this article retraces exchanges that actually occurred at the CSI, in a common effort to rebuild links between political, scientific, and artistic representations that had been disconnected by the traditional disciplines. Under the heading of a “return to the object,” Hennion draws a kind of partial archeology of the Inquiry by confronting in particular his own work on music, amateurs, and attachments and the actor-network-theory developed at the CSI. The review of reciprocal exchanges is woven between problems to do with science and technology, on the one hand, and culture, on the other, allowing him to address concepts and issues such as mediation and its contrast with translation, the question of attachments, the criticism of Bourdieu’s critical sociology, and the revival of pragmatism in social inquiries.
|
2022-12-20T22:06:57.488Z
|
236,998,924 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1021/jacs.1c06092",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
While a diverse set of design strategies have produced various chemical tools for biomolecule labeling in aqueous media, the development of nonaqueous, biomolecule-compatible media for bioconjugation has significantly lagged behind. In this report, we demonstrate that an aprotic ionic liquid serves as a novel reaction solvent for protein bioconjugation without noticeable loss of the biomolecule functions. The ionic liquid bioconjugation approach led to discovery of a novel triphenylphosphine-mediated amine-azide coupling reaction that forges a stable tetrazene linkage on unprotected peptides and proteins. This strategy of using untraditional media would provide untapped opportunities for expanding the scope of chemical approaches for bioconjugation.
|
2022-12-20T22:44:47.032Z
|
17,461,902 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1093/jrr/rrt034",
"MAG": "2775919757",
"PubMedCentral": "3823771"
},
"license": "CCBYNC",
"status": "GOLD",
"url": "https://academic.oup.com/jrr/article-pdf/54/6/1069/3919077/rrt034.pdf"
}
|
Before the sorafenib era, advanced but liver-confined hepatocellular carcinoma (HCC) was treated by liver-directed therapy. Hepatic arterial concurrent chemoradiotherapy (CCRT) has been performed in our group, giving substantial local control but frequent failure. The aim of this study was to analyze patterns of failure and find out predictive clinical factors in HCC treated with a liver-directed therapy, CCRT. A retrospective analysis was done for 138 HCC patients treated with CCRT between May 2001 and November 2009. Protocol-based CCRT was performed with local radiotherapy (RT) and concurrent 5-fluorouracil (5-FU) hepatic arterial infusion chemotherapy (HAIC), followed by monthly HAIC (5-FU and cisplatin). Patterns of failure were categorized into three groups: infield, intrahepatic-outfield and extrahepatic failure. Treatment failure occurred in 34.0% of patients at 3 months after RT. Infield, intrahepatic-outfield and extrahepatic failure were observed in 12 (8.6%), 26 (18.7%) and 27 (19.6%) patients, respectively. Median progression-free survival for infield, outfield and extrahepatic failure was 22.4, 18 and 21.5 months, respectively. For infield failure, a history of pre-CCRT treatment was a significant factor (P = 0.020). Pre-CCRT levels of alpha-fetoprotein and prothrombin induced by vitamin K absence or antagonist-II were significant factors for extrahepatic failure (P = 0.029). Treatment failures after CCRT were frequent in HCC patients, and were more commonly intrahepatic-outfield and extrahepatic failures than infield failure. A history of pre-CCRT treatment and levels of pre-CCRT tumor markers were identified as risk factors that could predict treatment failure. More intensified treatment is required for patients presenting risk factors.
|
2022-12-21T00:38:12.521Z
|
37,396,202 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1017/S0021932000019131",
"MAG": "2009760816",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
There are a large number of social, economic and biological variables which have been shown to associate with the growth and physical development of children. These variables include social class, nutritional and disease status, psychological stress, quality of the environment as measured by variation in housing conditions and degree of crowding, as well as genetic, neural and hormonal influences. The variation in growth under these influences is manifest in differences in stature. Since there are recent or forthcoming reviews on height variation in relation to migration (Boyce, 1984; Mascie-Taylor & Lasker, 1988), pollution (Schell, 1991) and climate (Greksa, 1991) these topics have, in general, not been included here. This review deliberately focuses on the various biosocial factors which influence height particularly in the context of industrialized societies although, where relevant, reference is also made to work carried out in developing countries.
|
2022-12-21T09:42:42.308Z
|
184,656,653 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.15359/ABRA.36-53.1",
"MAG": "2522535445",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Este articulo presenta un analisis; a partir de tecnicas multivariadas; para determinar las variables prioritarias de intervencion de un estudio de clima organizacional realizado en el 2013 en una Municipalidad en Costa Rica. El estudio inicial consistio en una descripcion general de la percepcion de variables que influyen en el clima organizacional de la misma, donde se analizaron 8 variables agrupadas en 3 dimensiones y recomendaciones para cada una de ellas. Los resultados del analisis con tecnicas multivariadas mostraron que la Municipalidad en estudio, si desea mejorar su clima debe priorizar y fortalecer acciones y recursos en las dimensiones de “Estructura, Procedimientos y Funciones” y “Motivacion y Compromiso”; especificamente en las variables “Comunicacion” y “Compromiso e Identidad”. Ademas, debe considerar que los puestos de jefatura confieren mayor valor a la variable “Compromiso” que los otros puestos y el personal con mas de cinco anos de laborar en la institucion a la variable “desafio y recompensa”. Se concluyo que el empleo de tecnicas multivariadas muestra tendencias especificas que aportan al estudio inicial insumos para la definicion de prioridades. En el caso de estudio los resultados del analisis multivariado indicaron que para el mejoramiento del clima organizacional, la Municipalidad debe orientarse, en primera instancia; a la planificacion de estrategias para el mejoramiento organizacional segun los hallazgos del analisis. Esto resulta fundamental para la definicion y orientacion presupuestaria e implementacion de las acciones propuestas en el estudio primario.
|
2022-03-10T12:08:41.121Z
|
144,299,077 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2307/369049",
"MAG": "2067926237",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
List of Tables and Figures List of Abbreviations Preface Acknowledgments A Twin Study of a Different Kind The Two Germanys Public and Private Values in the German Democratic Republic Education Values and the Law in the Federal Republic of Germany Goals of Education in East and West Who Runs the Schools? Different Schools for Different Twins The Curriculum: Free Choice and Diversity versus No Choice and Requirements Teaching and Learning in the Schools of East and West Conclusion: Alternative Schools-Hospitals or Laboratories? Bibliography Index
|
2022-09-09T12:13:42.014Z
|
95,254,580 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/MRC.1270080714",
"MAG": "2016676964",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The 1H n.m.r. spectra of doubly 15N labelled urea and 1,3-dimethylurea have been analysed with the aid of computer simulation. 1H1H, 1H15N, 15N15N and 13C15N (from 13C Ft spectra) couplings are reported.
|
2022-09-15T08:23:41.849Z
|
198,690,547 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.12968/cypn.2016.5.10",
"MAG": "2953858114",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Interim findings of a review of the youth justice system outline plans to devolve delivery to local communities and organisations, but justice experts warn this could have far-reaching consequences for youth offending teams
|
2022-10-27T15:59:09.364Z
|
4,882,002 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.19070/2379-156X-1600013",
"MAG": "2592667553",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
1 Department of Surgery, Research Institute NUTRIM, Maastricht University Medical Centre, AZ, Maastricht, The Netherlands. 2 Department of Surgery, Erasmus University Medical Centre Rotterdam, CA, Rotterdam, the Netherlands. 3 Department of Molecular Genetics, Research Institute CARIM, Maastricht University Medical Centre, AZ, Maastricht, The Netherlands. 4 Department of Pathology, Research Institute CARIM, Maastricht University Medical Centre, AZ, Maastricht, The Netherlands. 5 Department of Medical Biochemistry, Academic Medical Centre, Meibergdreef AZ, Amsterdam, The Netherlands.
|
2022-11-04T00:36:51.949Z
|
236,978,437 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1177/08862605211037433",
"MAG": null,
"PubMedCentral": "9554278"
},
"license": "CCBYNC",
"status": "HYBRID",
"url": "https://doi.org/10.1177/08862605211037433"
}
|
Debates on how sex, gender, and sexual identity relate to intimate partner violence (IPV) are longstanding. Yet the role that measurement plays in how we understand the distribution of IPV has been understudied. We investigated whether people respond differently to IPV items by sex and sexual identity and the implications this has for understanding differences in IPV burdens. Our sample was 2,412 randomly selected residents of Toronto, Canada, from the Neighborhood Effects on Health and Well-being (NEHW) study. IPV was measured using short forms of the Physical and Nonphysical Partner Abuse Scales (20 items). We evaluated the psychometric properties of this measure by sex and sexual identity. We examined whether experiences of IPV differed by sex and sexual identity (accounting for age and neighborhood clustering) and the impacts of accounting for latent structure and measurement variance. We identified differential item functioning by sex for six items, mostly related to nonphysical IPV (e.g., partner jealousy). Males had higher probabilities of reporting five of the six items compared to females with the same latent IPV scores. Being female and identifying as lesbian, gay, or bisexual were positively associated with experiencing IPV. However, the association between female sex and IPV was underestimated when response bias was not accounted for and outcomes were dichotomized as “any IPV.” Common practices of assuming measurement invariance and dichotomizing IPV can underestimate the association between sex or gender and IPV. Researchers should continue to attend to gender-based and intersectional differences in IPV but test for measurement invariance prior to comparing groups and analyze scale (as opposed to binary) measures to account for chronicity or intensity.
|
2022-12-13T01:57:20.511Z
|
18,320,815 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1089/wound.2015.0683",
"MAG": "2401866806",
"PubMedCentral": "5105345"
},
"license": "CCBY",
"status": "HYBRID",
"url": "https://www.liebertpub.com/doi/pdf/10.1089/wound.2015.0683"
}
|
Objective: Debridement to remove necrotic and/or infected tissue and promote active healing remains a cornerstone of contemporary chronic wound management. While there has been a recent shift toward less invasive polymer-based debriding devices, their efficacy requires rigorous evaluation. Approach: This study was designed to directly compare monofilament debriding devices to traditional gauze using a wounded porcine skin biofilm model with standardized application parameters. Biofilm removal was determined using a surface viability assay, bacterial counts, histological assessment, and scanning electron microscopy (SEM). Results: Quantitative analysis revealed that monofilament debriding devices outperformed the standard gauze, resulting in up to 100-fold greater reduction in bacterial counts. Interestingly, histological and morphological analyses suggested that debridement not only removed bacteria, but also differentially disrupted the bacterially-derived extracellular polymeric substance. Finally, SEM of post-debridement monofilaments showed structural changes in attached bacteria, implying a negative impact on viability. Innovation: This is the first study to combine controlled and defined debridement application with a biologically relevant ex vivo biofilm model to directly compare monofilament debriding devices. Conclusion: These data support the use of monofilament debriding devices for the removal of established wound biofilms and suggest variable efficacy towards biofilms composed of different species of bacteria.
|
2022-12-11T13:13:17.639Z
|
33,131,440 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1097/AOG.0000000000001266",
"MAG": "2599583473",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Preterm delivery occurs in approximately 12% of all births in the United States and is a major factor that contributes to perinatal morbidity and mortality (1, 2). Preterm premature rupture of membranes (PROM) complicates approximately 3% of all pregnancies in the United States (3). The optimal approach to clinical assessment and treatment of women with term and preterm PROM remains controversial. Management hinges on knowledge of gestational age and evaluation of the relative risks of delivery versus the risks of expectant management (eg, infection, abruptio placentae, and umbilical cord accident). The purpose of this document is to review the current understanding of this condition and to provide management guidelines that have been validated by appropriately conducted outcome-based research when available. Additional guidelines on the basis of consensus and expert opinion also are presented.
|
2022-12-19T06:51:15.398Z
|
145,119,899 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1142/S021849580400004X",
"MAG": "2080603966",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This paper aims to identify determinants of entrepreneurial intention among young people. The empirical basis is formed by surveys among Indonesian and Norwegian students. The main objective is to compare the impact of different economic and cultural contexts. Independent variables in the study include demographic factors and individual background, personality traits and attitudes, and contextual elements such as access to capital and information. The individual perceptions of self-efficacy and instrumental readiness are the variables that affect entrepreneurial intention most significantly. Age, gender and educational background have no statistically significant impact. Generally, the level of entrepreneurial intention is higher among Indonesian students. The lower level of entrepreneurial intention among Norwegian students is explained by the social status and economic remuneration of entrepreneurs in comparison with those enjoyed by employees in the Norwegian context.
|
2022-12-29T02:55:14.399Z
|
191,467,410 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.11606/ISSN.1981-7169.CRIOULA.2012.55570",
"MAG": "2069735207",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
O PRESENTE ENSAIO PROPOE UMA ANALISE COMPARATIVA COM ENFOQUE NOS GENEROS NARRATIVO E DRAMATICO. PARA TANTO, TOMA COMO CORPUS O ROMANCE D’A PEDRA DO REINO (1971), DE ARIANO SUASSUNA, E INVESTIGA OS RECURSOS QUE PROPORCIONAM UM EFEITO DRAMATICO NA REFERIDA OBRA. AO CONTAR EPISODIOS DE SUA VIDA COM PINCELADAS DE HUMOR, DE HEROISMO E DE AVENTURA, O NARRADOR PROTAGONISTA QUADERNA IMAGINA A TESSITURA DE UM ROMANCE QUE SE MOSTRA PARA O LEITOR COMO UMA PECA ENCENADA DEVIDO A PLASTICIDADE E AO TOM ORAL E ELOQUENTE EMPREGADO EM SEU NARRAR.
|
2022-02-08T09:04:19.521Z
|
33,016,994 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1136/BMJ.2.3023.625",
"MAG": "1997849484",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
invaded and replaced by an inflammatory fibrous tissue (Fig. 6, d) or new bone may develop in, the ankylosed cartilage and thus bring about osseous ankylosis. Osseous ankylosis takes places by the development of new bone either in ankylosed cartilage or in the fibrous tissae which lhas already produced fibrous ankylosis. Ankylosis may occur between the two zones of calcified cartilage, but this form of fusion shows a tendency to become replaced by one of true bone. Villous outgrowthls are found in some joints. These may be due to (a) overgrowth of normal villi; (b) inflammatory changes in the synovial membrane or in the capsule. Villous outgrowths in a joint may consist of (a) vascular fibrous tissue, (b) dense fibrous tissue, (c) fibrous tissue enclosing groups of fat cells, (d) inflammatory tissue with dilated, capillaries and groups of inflammatory cells, (e) degenerated or necrotic tissue, (f) connective tissue showing vessels deeply congested owing to obstructed circulation. Villous outgrowths may become detached by rupture of tlle fine pedicles, and so forin a loose body in the joint cavity. Tlle detaclhment may be preceded by necrosis. Microscopic villi formed of cartilage are occasionally found on the surface of altered articular cartilage. These may be formed of hyaline or fibro-cartilage. No constant clhanges are found after death in the organs or tissuies of patients wlho lhave suffered from rheumatoid arthritis.
|
2022-08-23T17:24:34.717Z
|
97,476,996 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/10426500802111090",
"MAG": "2116583708",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The reaction of 2-phenyl-5-(4H)-oxazolone 1 and its 4-benzylidene derivative 2 with oxovinylidenetriphenylphosphorane 3 afforded 2-phenylfuro [3,2-d] [1,3]oxazol-5-(6H)-one 6 and 2,7-diphenyl-5H-pyrano[3,2-d][1,3]oxazol-5-one 7 along with triphenylphosphine. Alternatively, when 2-phenyl-5-(4H)-oxazolone 1 reacts with phosphorus ylides 4a–f the corresponding new phosphorane, the cyclic and/or the olefinic adducts were obtained. Moreover, oxazolone reacts with N-(triphenylphosphoranylidene)aniline 5 to give the new imino product 14 together with triphenylphosphine oxide. Possible reaction mechanisms are considered and the structural assignments are based on analytical and spectroscopic results. Biological evaluations of the new products are also studied.
|
2022-09-07T11:34:03.123Z
|
91,871,530 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.31018/JANS.V8I2.831",
"MAG": "2909673001",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In the present investigation, experiment was conducted for in vitro micro-propagation with different concentration of growth regulators in different explants Sprouts and Shoot tips of potato cultivar Kufri Frysona. The maximum survival percentage (40) of sprouts and (100%) of shoot tips were obtained when the explants were surface sterilized with 0.2% bavistin & 0.4% streptocyclin (45minutes) and 0.1% mercuric chloride (60seconds). Sterilized explants were inoculated on MS basal supplemented with various growth regulators and established successfully. The maximum shoot induction (62.5±1.44%) in 11.3±0.33 days and (74.0 ± 2.13 %) in 10.0 ± 0.50 days were reported on medium PM1 (BAP 0.25 mg/l) in sprouts and shoot tip explants respectively. The sprouted explants were further sub-cultured on MS media supplemented with various growth regulator alone and in combination for in vitro multiplication. In Kufri Frysona (11.2) shoots were obtained on MS medium fortified with 0.25mg/l BAP + 0.01mg/l IAA on 42th day of subculture. In vitro rooting was observed on MS basal medium supplemented with 2.0 mg/l NAA in Kufri Frysona after 10 days. Rooted plantlets were successfully hardened in green house using different types of potting mixture and finally transferred to field. The protocol will be very useful for large-scale production of disease free planting material of potato (S. tuberosum) in future.
|
2022-10-11T20:39:22.111Z
|
140,699,643 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1144/gsjgs.146.4.0600",
"MAG": "2128606568",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A reconnaissance study is outlined showing how an improved understanding of the formation and character of fossil vertebrate tracks in soft sediments is provided by the application of the mechanical engineer’s indenter theory, supported by complementary scaled laboratory experiments. Only the footprint at the bottom of the shaft cut by the animal's limbs in general offers the best preservation of the shape of the underside of the foot. The character of the foot is less well preserved in the deformed bedding beneath the footprint and among laminae deposited in the shaft after the passage of the animal. This understanding will help to reduce errors in the use of tracks in taxonomic, biostratigraphic, palaeoecological, behavioural and environmental studies. When a limbed vertebrate traverses yielding sediment, the limbs deform the substrate into tracks which vary with the nature, size and gait of the animal, the forcefulness of its limb movements, and the sediment properties. Most previous geological work on tracks and trackways has emphasized their taxonomic, biostratigraphical, palaeocological and behavioural significance (Lockley 1986; Leonardi 1987), but without an adequate understanding of their environmental implications (Lockley 1986) and, in particular, their genesis and preservation as trace fossils. The response of an elastic-plastic material to an indenter or punch, both in terms of theory (Calladine 1969; Hill 1971; Johnson et al. 1982) and in the light of qualitative laboratory experiments, provides a general mechanical model for track formation and a basis for the assessment of track preservation in sediments. The indenter represents the animal's
|
2022-12-09T10:11:15.238Z
|
128,687,137 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1029/97GL00287",
"MAG": "2043869885",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The dependence of the summed moment release on the fault dimension differs between non‐creeping faults and creeping faults or volcanic regions. This can be attributed to different earthquake scaling laws. The number N of events with fault length L scales for non‐creeping faults as N(L' ∼ L−2 and for creeping faults as N(L' ∼ L−3. This difference offers a means for mapping the distribution of creep in the seismogenic crust.
|
2022-12-19T10:35:50.351Z
|
31,923,200 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/sys.21274",
"MAG": "1985828176",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Requirements categorization is an inherent part of the requirements engineering activity. Conventional approaches use a designer perspective (requirements organized according to design needs or attributes), a contractual perspective (requirements organized according to procurement or acquisition needs), or a combination of both. Such models present several inconveniences that result in limitation of system affordability: facilitate the generation of overlapping requirements, of design‐dependent requirements, and of a mix of requirements applicable to different levels of the architecture decomposition or to different products. The present research proposes a Need‐based Categorization (NbC) model that is system‐centric: Requirements are organized around the system. Inspired by Max‐Neef's model of human needs, the proposed model supports requirement elicitation by defining only what the system does, how well, where, and what it uses to accomplish it. The model facilitates the identification of constraints that limit the solution tradespace without supporting the satisfaction of new needs, of overlapping requirements, and of requirements that are not applicable to the system. Finally, the proposed model defines requirements in subsets that are associated with value to stakeholders, thus reflecting the actual dependency nature of requirements at a given level of an architecture decomposition, which promotes holistic decisions instead of local optimizations.
|
2023-01-01T20:56:05.324Z
|
64,824,609 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.15748/JASSE.4.31",
"MAG": "2794538088",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The current approach to solving large-scale traffic problems is with the simulation of microscopic vehicle behaviors. However, few simulators are capable of conducting such simulations due to the high computational cost. In this study, we propose a new route search method using a simplified network to achieve speedup. We developed a practical implementation for a microscopic traffic simulator and applied the proposed method to a real road network in Okayama city under a dynamic routing condition. The results show that the proposed method reduces the number of links and nodes for route searches by 80% and the route search execution time by 98%.
|
2022-08-29T03:48:40.471Z
|
84,901,193 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1126/SCIENCE.277.5333.1783B",
"MAG": "2048028728",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Eukaryotic DNA Replication. J. JULIAN BLOW, Ed. IRL (Oxford University Press), New York, 1996. xx, 232 pp., illus. $105 or £65, ISBN 0-19-963586-2; paper, $55 or £29.95, ISBN 0-19-963585-4. Frontiers in Molecular Biology, 15.
|
2022-07-19T11:11:46.563Z
|
22,467,625 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1001/ARCHDERM.1976.01630340015003",
"MAG": "2129266944",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The skin of 214 institutionalized patients with the Down syndrome was carefully examined. There were 19 cases of alopecia areata and four cases of vitiligo. Since persons with the Down syndrome are predisposed to immunological deficiency in thymus-dependent (T-cell) function, findings from the skin examinations suggest that immunologic factors might contribute to the increased incidence of vitiligo and alopecia areata seen in the Down syndrome. Syringoma was also common and affected female patients twice as frequently as male patients.
|
2022-12-14T13:25:42.555Z
|
206,380,600 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1021/acs.accounts.6b00237",
"MAG": "2517162516",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Biosensors for highly sensitive, selective, and rapid quantification of specific biomolecules make great contributions to biomedical research, especially molecular diagnostics. However, conventional methods for biomolecular assays often suffer from insufficient sensitivity and poor specificity. In some case (e.g., early disease diagnostics), the concentration of target biomolecules is too low to be detected by these routine approaches, and cumbersome procedures are needed to improve the detection sensitivity. Therefore, there is an urgent need for rapid and ultrasensitive analytical tools. In this respect, single-molecule fluorescence approaches may well satisfy the requirement and hold promising potential for the development of ultrasensitive biosensors. Encouragingly, owing to the advances in single-molecule microscopy and spectroscopy over past decades, the detection of single fluorescent molecule comes true, greatly boosting the development of highly sensitive biosensors. By in vitro/in vivo labeling of target biomolecules with proper fluorescent tags, the quantification of certain biomolecule at the single-molecule level is achieved. In comparison with conventional ensemble measurements, single-molecule detection-based analytical methods possess the advantages of ultrahigh sensitivity, good selectivity, rapid analysis time, and low sample consumption. Consequently, single-molecule detection may be potentially employed as an ideal analytical approach to quantify low-abundant biomolecules with rapidity and simplicity. In this Account, we will summarize our efforts for developing a series of ultrasensitive biosensors based on single-molecule counting. Single-molecule counting is a member of single-molecule detection technologies and may be used as a very simple and ultrasensitive method to quantify target molecules by simply counting the individual fluorescent bursts. In the fluorescent sensors, the signals of target biomolecules may be translated to the fluorescence signals by specific in vitro/in vivo fluorescent labeling, and consequently, the fluorescent molecules indicate the presence of target molecules. The resultant fluorescence signals may be simply counted by either microfluidic device-integrated confocal microscopy or total internal reflection fluorescence-based single-molecule imaging. We have developed a series of single-molecule counting-based biosensors which can be classified as separation-free and separation-assisted assays. As a proof-of-concept, we demonstrate the applications of single-molecule counting-based biosensors for sensitive detection of various target biomolecules such as DNAs, miRNAs, proteins, enzymes, and intact cells, which may function as the disease-related biomarkers. Moreover, we give a summary of future directions to expand the usability of single-molecule counting-based biosensors including (1) the development of more user-friendly and automated instruments, (2) the discovery of new fluorescent labels and labeling strategies, and (3) the introduction of new concepts for the design of novel biosensors. Due to their high sensitivity, good selectivity, rapidity, and simplicity, we believe that the single-molecule counting-based fluorescent biosensors will indubitably find wide applications in biological research, clinical diagnostics, and drug discovery.
|
2022-12-17T00:53:22.606Z
|
71,670,876 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5762/KAIS.2011.12.8.3523",
"MAG": "1993302750",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This study was intended to measure the quality of sleep according to the job stress contents among nurses working for an university hospital. The self-administered questionnaires were given to 482 nurses employed in an university hospital during the period from June 1st to July 31st, 2011. As a results, the quality of sleep was significantly lower in the group with higher job demand, lower job control, lower supervisor and coworker support. In correlation, the level of quality of sleep was positively correlated with job demand, but it was negatively correlated with job control, supervisor and coworker support. In logistic regression analysis, the adjusted odds ratio of the quality of sleep was significantly increased in higher group of job demand than in lower group. But it was significantly decreased in higher group of supervisor and coworker support. The study results may explain that the quality of sleep is independently associated with the job stress contents.
|
2022-12-18T11:40:22.695Z
|
43,169,789 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/TASC.2008.920833",
"MAG": "2111062870",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A high temperature superconducting (HTS) DC cable is ideal for transmitting large amount of electrical power over a long distance. However, it must be designed to operate reliably within the constraints of the electrical systems. Therefore, a study of the electrical insulation is important to develop a HTS DC cable because it is operated in a cryogenic high voltage environment. This paper discusses the dielectric constructions of the cable and summarizes the experiment results on the DC and impulse dielectric characteristics of the insulation material, in sheet form and mini-model cable configuration. This shows how to design such insulation to be operated reliably. These studies are essential for the insulation design of a HTS DC cable operating in cryogenic environment.
|
2022-02-12T02:20:43.784Z
|
110,737,987 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1177/108056999005300201",
"MAG": "2063799921",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Just a few years ago, most business communication textbooks made no mention of collaborative writing, journals published only occasional articles on the subject, and many of our colleagues ignored collaboration~onsidering it at best a special interest area at conferences, at worst the current fad from composition. Today, collaborative writing has become a central concern for business communication-a topic that cannot be ignored by textbook authors, by journal editors, or by
|
2022-12-22T16:40:18.521Z
|