corpusid
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255M
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202,359,646 |
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"DOI": "10.1080/08961530.2018.1561345",
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Abstract This study examines the salient organic food related values driving consumers’ attitude and purchase intentions in a developing country (Iran) and a developed country (US). Additionally, we explain and compare the role of subjective norms in organic food purchase intention between these countries. To examine, the organic food values and patterns of consumers’ organic food choices, we collected data from 217 and 210 respondents in Iran and the US, respectively. Our findings show that “Price” in Iran and “Authenticity/naturalness” in the US were the strongest predictors of attitude toward the organic food. Eating culture, consumer’s knowledge, perceptions, and concerns in society could be the underlying reason for the differences in importance of values between two societies. We also found the relationship of subjective norms with purchase intention varies across societies. At the end of this study, we discuss the implications for international marketing campaigns and for policy makers in each country.
|
2022-12-30T18:16:04.643Z
|
24,125,845 |
{
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"DOI": "10.3944/AOTT.2015.14.0346",
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|
OBJECTIVE
The purpose of this study was to investigate the objective and subjective outcomes of proximal row carpectomy (PRC) for stage III Kienböck's disease and determine if the physician's objective measurements correlate with the patients' subjective outcomes.
METHODS
Twenty-four patients who underwent PRC for stage III Kienböck's disease with a follow-up period of more than 18 months were enrolled in the study. Clinical evaluation included preoperative and postoperative Quick Disabilities of the Arm, Shoulder and Hand (Q-DASH) questionnaire, postoperative Mayo wrist score, postoperative total joint range of motion (ROM), as well as grip and pinch strength measurements of the operated and normal side. Radiographic criteria such as carpal height ratio, subchondral cyst, and osteophyte formation were assessed during the follow-up period. Mean follow-up period was 41.7 months (range: 18-106 months).
RESULTS
No wrists underwent total arthrodesis. Reflex sympathetic dystrophy was observed in 2 patients (8.3%). Postoperative ROM measurements, power grip, and pinch strength values significantly decreased in both stages (IIIA and IIIB) on the operated side compared to the normal side. In contrast, Q-DASH scores significantly increased in both stages compared to preoperative values. Average Mayo wrist score was 67.3 (range: 10-90).
CONCLUSION
PRC is a well-tolerated procedure for stage III Kienböck's disease with certain complications. While subjective values improved significantly, there was no correlation between this improvement in subjective values and objective measurements. PRC was not able to restore motion postoperatively to that of the normal side, even though this feature did not affect postoperative subjective patient satisfaction.
|
2022-08-24T04:46:22.265Z
|
73,250,084 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.1108/WWOP-08-2013-0020",
"MAG": "2116896051",
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|
– The purpose of this paper is to describe the findings from a research project that explored the mental health experiences and expectations of the so-called “baby boomer” population born between 1946 and 1955 who are now moving into later life. , – The research combined primary and secondary research, and a panel of experts. The primary research was both quantitative and qualitative. , – Findings covered issues of identity, health and wellbeing, family and relationships, work, occupation, retirement and financial security, as well as key implications for policy makers, opinion formers and decision makers. , – The “baby boomer” cohort is extremely large and to provide definitive findings on such a wide range of aspects that potentially influence their mental health requires a much larger study than this as well as one that focuses on particular sub-groups of this cohort. It also raises the question of similarities and differences between this cohort and the second wave of baby boomers born between the late 1950s and early 1960s. , – This is an important piece of research, drawing together a wide range of resources and data to provide a unique overview of a key dimension of health for this group in the population which because of their numbers as well as perceived shared life experiences will be of great interest to policy makers, academics and the media, as well as members of this population cohort and people who have an interest in them.
|
2022-09-06T02:38:14.014Z
|
159,681,178 |
{
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"ArXiv": null,
"DOI": "10.1353/CAT.1997.0132",
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|
The Gunpowder Plot.' Terror and Faith in 1605. By Antonia Fraser. (London: Weidenfeld and Nicolson.1996. Pp. xxxv,347.L20.00.) This is a handsome production, well illustrated and indexed, based on good sources, and presented in a prose at once elegant and readable, which we would expect by now from this author. It has been well received by reviewers generally in England who usually reveal little knowledge about the plot except from what they read here. It is safe to prophesy that there will never be a last word on what Joel Hurstfield once described as a "non-event"; but it is to be regretted that one cannot recommend this as an outstanding milestone on the way. The book refers to a "no plot" faction, but no one denies a plot. The question remains, whose was it and of what kind? Fraser retells the traditional story of the plot as the concoction of a group of disaffected Catholics driven to desperation and despair by persecution and seeing no other remedy.The dark hero of the piece was dashing Robert Catesby, whose zeal inflamed and led the rest to all-time disaster for the Catholic cause. She follows in essentials Mark Nicholls's thesis as expounded in Investigating Gunpowder Plot (1991) and also an unpublished manuscript by the late W K. L.Webb, SJ. It is extremely plausible that this was the way of it since we are all too well aware of the terrorist answer to seemingly insoluble political problems in our own time. Nevertheless, closer inspection of the evidence, which is, admittedly, often unsatisfactory and incomplete, must confirm many in the view that the plot was Robert Cecil's contrivance-one of quite a series which began with the Lopez plot of 1594, which no one takes seriously, and the Squire plot of 1598, aimed at the Jesuits, which nobody would take seriously if people knew anything about it.The Main and Bye plots were rather better contrived but still bear the falsifying imprint of the master.The gunpowder plot,"Cecil's holiday" as it was described by contemporaries, was the last and best stage-managed of them all, so skillfully that it continues to deceive even those it was intended to destroy down to our day. It is the great outcrop sticking up in our English sands of time to hold back the sinister force of popish revisionism. Cecil had two aims in mind: first to bring the papists into everlasting hatred; second to discredit those Catholics and their cause who, finding nothing worthwhile for them to do in his England, tried to find employment and honor abroad fighting for the archdukes in Flanders.The oblique attack on the English regiment is an essential part of the story.The group which made its way to the last stand at Holbeach on November 8 was the remnant of a contingent intended for Flanders. Guy Fawkes, prototype of the fall-guy and the only professional soldier, was their liaison man. The operation was infiltrated by four men working for Cecil, viz., Thomas Percy, the principal mole, with Robert Catesby as his main contact in the field, and William Monteagle and Francis Tresham as assistants. …
|
2022-09-13T05:23:04.895Z
|
6,106,866 |
{
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"ArXiv": null,
"DOI": "10.3109/17453674.2015.1103568",
"MAG": "2190856065",
"PubMedCentral": "4940593"
},
"license": "CCBYNC",
"status": "GREEN",
"url": "https://europepmc.org/articles/pmc4940593?pdf=render"
}
|
Background and purpose — Aseptic revisions comprise 80% of revision total knee arthroplasties (TKAs). We determined the incidence of re-revision TKA, the reasons for re-revision, and risk factors associated with these procedures. Patients and methods — We conducted a retrospective cohort study of 1,154 patients who underwent aseptic revision TKA between 2002 and 2013 and were followed prospectively by a total joint replacement registry in the USA. Revision was defined as any operation in which an implanted component was replaced. Patient-, surgeon-, and procedure-related risk factors were evaluated. Survival analyses were conducted. Results — There were 114 re-revisions (10%) with a median time to reoperation of 3.6 years (interquartile range (IQR): 2.6–5.2). The infection rate was 2.9% (34/1,154) and accounted for 30% of re-revisions (34 of 114). In adjusted models, use of antibiotic-loaded cement was associated with a 50% lower risk of all-cause re-revision surgery (hazard ratio (HR) = 0.5, 95% CI: 0.3–0.9), age with a 20% lower risk for every 10-year increase (HR = 0.8, CI: 0.7–1.0), body mass index (BMI) with a 20% lower risk for every 5-unit increase (HR = 0.8, CI: 0.7–1.0), and a surgeon’s greater cumulative experience (≥ 20 cases vs. < 20 cases) with a 3 times higher risk of re-revision (HR = 2.8, CI: 1.5–5). Interpretation — Revised TKAs were at high risk of subsequent failure. The use of antibiotic-loaded cement, higher age, and higher BMI were associated with lower risk of further revision whereas a higher degree of surgeon experience was associated with higher risk.
|
2022-12-07T22:05:46.258Z
|
147,937,784 |
{
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"ArXiv": null,
"DOI": "10.21153/DLR2007VOL12NO1ART168",
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}
|
Australian courts are already dealing with issues around electronic documents and technology in the pre-trial and trial stages of litigation, in particular in cases involving large volumes of documentation. However issues surrounding the ease with which such documents can be disseminated have troubled the courts. The adoption of new technology is gathering pace, but the courts are proceeding with caution.
|
2022-12-10T09:18:14.016Z
|
28,474,117 |
{
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"ArXiv": null,
"DOI": "10.1136/bmj.296.6632.1281",
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"status": "GREEN",
"url": "https://europepmc.org/articles/pmc2545763?pdf=render"
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|
The end tidal partial pressure of carbon dioxide (Pco2) was measured during treadmill exercise in 30 normal controls and 113 patients referred for assessment of chest pain. Among the 92 patients without significant ST depression hypocapnia occurred more often in those reporting “typical” than “atypical” chest pain (17 of 22 patients compared with 29 of 70; p<0·01). Hypocapnia was uncommon in patients with significant ST depression whether reporting typical or atypical chest pain (one of 10 patients and two of 11, respectively). Hypocapnia at rest (Pco2 <4 kPa) occurred in 16 (14%) patients but in only one control. Hypocapnia occurred during or after exercise in only one control and three of the 21 patients with significant ST depression on exercise (group 1). The remaining 92 patients were divided into those with a history suggestive of hyperventilation (group 2; n=30) and those without (group 3; n=62). Hypocapnia developed significantly more often in both these groups (21 and 25 patients respectively) than in controls or patients with significant ST depression. An abnormal response of the Pco2 to exercise provided objective data to support a clinical suspicion of chest pain induced by hyperventilation in 24 cases, suggested a cause for equivocal ST depression other than coronary stenosis in five patients, and led to the diagnosis of previously unsuspected respiratory disease in 14 patients. Measurement of end tidal Pco2 gives additional valuable diagnostic information during the conventional treadmill exercise test in patients with both typical and atypical chest pain.
|
2022-12-17T10:22:17.204Z
|
137,421,427 |
{
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"ACL": null,
"ArXiv": null,
"DOI": "10.1146/ANNUREV.MATSCI.38.060407.130231",
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"status": null,
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|
This review critically examines the experimental aspects of dynamic wetting, considering extant data for different geometries. Both partial wetting and complete wetting are considered for cases that include droplets, fibers, tubes, and plates. The wetting of porous materials is also considered, along with the new field of micro- and nanofluidics.
|
2022-12-20T17:41:07.683Z
|
203,624,712 |
{
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"ArXiv": null,
"DOI": "10.1002/adma.201904957",
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"license": "CCBYNC",
"status": "HYBRID",
"url": "https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/adma.201904957"
}
|
Responsive interfaces are interfaces that show a defined and reversible change in physical properties in response to external stimuli. Typically, responsive interfaces result from the immobilization of responsive molecular components at the interface that translate a nanoscale signal into a macroscopic effect. Responsive interfaces can also be obtained if the topology of the interface can be reversibly changed using an external stimulus. As the surface of any material is its connection to the environment, responsive interfaces provide opportunities for interactive materials which are not only able to change properties upon demand, but also sense their environment and act autonomously. The application of responsive molecular components at interfaces, however, requires chemical and physical compatibility with the material surface of interest, posing a challenge not least in the retention of the responsive functionality. The state of the art in “active” interfaces which display responsive wettability, permeability, or adhesion is discussed, with a particular emphasis on microscale and nanoscale patterning since patterned interfaces can give rise to unique material properties. Finally, perspectives in the development of responsive interfaces, as well as promising approaches for bypassing the most prominent challenges are discussed.
|
2022-12-20T12:08:03.475Z
|
94,838,552 |
{
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"ArXiv": null,
"DOI": "10.1116/1.586547",
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|
Choosing the correct passivation film can be a complicated task. Factors such as sidewall integrity, sodium penetrability, and ability to withstand postpassivation temperature cycles must be considered. Previous studies have defined standard techniques for testing sidewall integrity and sodium barrier ability. In this study, the effect of thermal cycle exposure on the sidewall integrity of plasma enhanced chemical vapor deposition (PECVD) passivation films (TEOS‐based oxide, oxynitride, and nitride) by varying factors such as film type, metal sputter temperature, and film stress was examined. It will be shown that metal sputter temperature and film stress are much more important than film type. In addition, the newer generation of TEOS‐based phosphorous‐doped passivation films was compared to the standard, silane‐based phosphosilicate glass which is deposited using atmospheric pressure chemical vapor deposition (APCVD). The conclusion is that APCVD films are slightly better as deposited, but degrade durin...
|
2022-08-29T01:49:53.753Z
|
218,818,825 |
{
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"ACL": null,
"ArXiv": null,
"DOI": "10.1080/09720529.2020.1726079",
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"url": null
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|
Abstract In the last decade, Sparse representation method of classification has proved its efficiency for face recognition applications. The major challenge for face recognition algorithms is partial occlusion and expression changes in face images. In case of upper or lower face occlusion, a large portion of discriminative information gets missing which results into lower classification accuracy. In this paper a novel two quadrant sparse classifier is proposed which implements sparse representation in two different quadrants. Proposed classifier uses visual face information present in upper and lower quadrants independently to classify the test face image which provides correct classification even if one quadrant is occluded. The enhanced accuracy of proposed technique is proved using extensive simulations carried out on two standard databases (ORL and YALE). The experimental results for all number of training images and training sets are compared with simple sparse method in terms of mean classification accuracy. The performance of proposed technique is analysed with a maximum improvement of 3.51 % in terms of classification accuracy.
|
2022-09-08T21:34:57.696Z
|
2,147,893 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/APCC.2006.255929",
"MAG": "1986840202",
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},
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}
|
In this paper, we investigate the link failure problem of network coding for point-to-point networks, multicast networks, and multi-source multi-sink networks, respectively. We decompose the total network link space into three disjoint parts such as the A-set, the B-set and another one, where the A-set include the most important edges to the network capacity and the B-set include the edges having less influence on the network capacity. It is shown that the A-set and B-set of a network can be found out in polynomial time. According to the results of link decomposition, some basic algebraic structures of the link failure space are proposed
|
2022-09-15T02:45:54.332Z
|
217,965,407 |
{
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"DOI": "10.1360/n972015-00025",
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}
|
The emission of CO2 continues to cause serious environmental problems, and there has therefore been a considerable increase in the number of researcher working towards the development of new technologies for the capture and utilization of CO2. As a green, abundant, cheap and renewable C1 resource, CO2 could participate in a wide range of chemical reactions, and could therefore be converted into various value-added chemicals. The conversion of CO2 into other value-added chemicals therefore represents an important way to use CO2, although it contributes very little to reducing the concentration of CO2 in the Earths atmosphere. The green features of CO2-involved chemical processes are of critical importance from the perspective of sustainable development. However, only a few industrial processes have been reported that use CO2 as a raw material because CO2 is thermodynamically stable and chemically inert. To achieve chemical transformations with CO2, a high energy input is generally required, which can be achieved using highly reactive chemicals, specific catalytic systems and high temperature/pressure conditions. Based on these rules, research towards the development of CO2 chemical conversion processes has made great progress. CO2 has been successfully used as a green C1 building block for the production of a variety of different value-added chemicals via the construction of C-H, C-C, C-O and C-N bonds. In particular, CO2 hydrogenation processes and reactions involving the formation of C-O bonds have been widely investigated. Furthermore, the CO2-based synthesis of chemicals via the construction of C-N and C-C bonds has recently attracted considerable attention from numerous researchers, and many excellent results have been reported in literature. For example, aziridines, amino alcohols, acetylenic amines, primary amines, secondary amines, 2-aminobenzonitrile, 1,2-diamines and o-phenylenediamines have all been reacted with CO2 as nitrogen-containing nucleophiles to give the corresponding oxazolidinones, ureas, quinazolines, imidazolidones and benzimidazoles via the formation of C-N bonds. Organozinc compounds, organoboronic esters, dienes, alkenes, alkynes, aryl halides and arenes bearing acidic C-H bonds have also been reacted as nucleophiles with CO2 to give the corresponding aromatic acids and aromatic aldehydes via the construction of C-C bonds. In most cases, it has been demonstrated that catalysts can play a crucial role in the transformation of CO2. It is noteworthy that the chemical transformation of CO2 can be achieved under mild conditions, even at room temperature under atmospheric pressure, through the design of highly efficient catalytic systems. This review will provide a summary of recent advances in the field of CO2-based C-N and C-C bond formation processes for the production of oxazolidinones, quinazolinediones, ureas, isocyanates, imidazolinones, benzimidazoles, aromatic acids and aromatic aldehydes, with particular emphasis on the catalytic systems used to achieve these transformation and possible catalytic reaction mechanisms. This review should therefore provide basic ideas with regard to the use CO2 as an ideal and attractive C1 source in organic synthesis to generate value-added chemicals.
|
2022-10-19T14:32:44.537Z
|
138,577,805 |
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"DOI": "10.2172/6545611",
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"status": "GREEN",
"url": "https://digital.library.unt.edu/ark:/67531/metadc866471/m2/1/high_res_d/1118081.pdf"
}
|
This report summarizes the fiscal year (FY) 1992 progress of the subcontracted photovoltaic (PV) research and development (R D) performed under the Photovoltaic Advanced Research and Development Project at the National Renewable Energy Laboratory (NREL)-formerly the Solar Energy Research Institute (SERI). The mission of the national PV program is to develop PV technology for large-scale generation of economically competitive electric power in the United States. The technical sections of the report cover the main areas of the subcontract program: the Crystalline Materials and Advanced Concepts project, the Polycrystalline Thin Films project, Amorphous Silicon Research project, the Photovoltaic Manufacturing Technology (PVMaT) project, PV Module and System Performance and Engineering project, and the PV Analysis and Applications Development project. Technical summaries of each of the subcontracted programs provide a discussion of approaches, major accomplishments in FY 1992, and future research directions.
|
2022-10-28T00:35:39.482Z
|
14,831,555 |
{
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"DOI": "10.1159/000446836",
"MAG": "2461044803",
"PubMedCentral": "4965536"
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"license": "CCBYNC",
"status": "GOLD",
"url": "https://www.karger.com/Article/Pdf/446836"
}
|
Atopic dermatitis (AD) is a chronic, pruritic skin disease often complicated by bacterial superinfection affecting 10.7% of American children. The pathogenesis involves a skin barrier breakdown in addition to dysfunctional innate and adaptive immune response, including an unbalanced increase in T-helper 2 cells and hyperimmunoglobulinemia E. The increased numbers of T-helper 2 cells are involved in stimulating the production of immunoglobulin E and eosinophilia by releasing interleukin-4, -5, and -13 as well as in decreasing protection against bacterial superinfection by releasing interleukin-10. The current Food and Drug Administration-approved symptomatic treatment for AD includes topical ointments, topical and systemic corticosteroids, topical immunomodulant therapy, antibiotics, and phototherapy, but there are not approved targeted therapies or cures. By presenting a case of an 8-year-old African-American boy, this case report supports novel therapy of moderate-to-severe AD with apremilast, a phosphodiesterase type 4 inhibitor. Apremilast has recently completed the phase 2 clinical trial (NCT02087943) for treatment of AD in adults. This case report illustrates the potential for apremilast as a treatment for AD in children, where there is a great need for safe and effective medications.
|
2022-12-09T19:30:35.112Z
|
31,574,416 |
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"DOI": "10.1128/jcm.30.3.655-662.1992",
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"url": "https://europepmc.org/articles/pmc265127?pdf=render"
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|
The transfer of six internal RNA segments from the avian influenza A/Mallard/New York/6750/78 (H2N2) virus reproducibly attenuates human influenza A viruses for squirrel monkeys and adult humans. To identify the avian influenza A virus genes that specify the attenuation and host range restriction of avian-human (ah) influenza A reassortant viruses (referred to as ah reassortants), we isolated six single-gene reassortant viruses (SGRs), each having a single internal RNA segment of the influenza A/Mallard/New York/6750/78 virus and seven RNA segments from the human influenza A/Los Angeles/2/87 (H3N2) wild-type virus. To assess the level of attenuation, we compared each SGR with the A/Los Angeles/2/87 wild-type virus and a 6-2 gene ah reassortant (having six internal RNA segments from the avian influenza A virus parent and two genes encoding the hemagglutinin and neuraminidase glycoproteins from the wild-type human influenza A virus) for the ability to replicate in seronegative squirrel monkeys and adult human volunteers. In monkeys and humans, replication of the 6-2 gene ah reassortant was highly restricted. In humans, the NS, M, PB2, and PB1 SGRs each replicated significantly less efficiently (P less than 0.05) than the wild-type human influenza A virus parent, suggesting that each of these genes contributes to the attenuation phenotype. In monkeys, only the NP, PB2, and possibly the M genes contributed to the attenuation phenotype. These discordant observations, particularly with regard to the NP SGR, indicate that not all genetic determinants of attenuation of influenza A viruses for humans can be identified during studies of SGRs conducted with monkeys. The PB2 and M SGRs that were attenuated in humans each exhibited a new phenotype that was not observed for either parental virus. Thus, it was not possible to determine whether avian influenza virus PB2 or M gene itself or a specific constellation of avian and human influenza A virus specified restriction of virus replication in humans.
|
2022-12-26T16:08:43.924Z
|
83,426,067 |
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"DOI": "10.15421/010838",
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"license": "CCBY",
"status": "HYBRID",
"url": "https://ecology.dp.ua/index.php/ECO/article/download/299/289"
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|
It was shown that some emergent aquatic plants may be used for treatment of waste waters. The plants have specific composition of surface lipids (SL). The SL composition was found to be changed under the influence of water pollutants. These changes concerned the processes of elongation and desaturation of the SL components. The response to contamination was specific for each species.
|
2022-12-30T00:24:29.820Z
|
149,168,070 |
{
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"DOI": "10.1215/10642684-3818453",
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|
As a gay man directing straight hardcore pornographic films in the 1970s, Zebedy Colt smuggled a certain queer eros into the visual culture of heterosexuality. Indeed, he belonged to a queer cohort of hetero-pornographers whose subversive flourishes have gone largely unrecognized by porn studies and queer studies scholars, in part because of the incomplete archives generally used to narrate and analyze pornography. Yet Colt's work, in such films as The Devil Inside Her (1976), Sex Wish (1976), Virgin Dreams (1977), and others, was a reactionary queer cinema, in which he leveraged a particularly misogynistic white masculinity to achieve his queer interventions. This article attends to both his implantation of queer desire into the heart of normative heterosexuality and the gender and racial politics that allowed heteromasculinity to absorb those seeming challenges without any threat of veering toward a queer utopian horizon.
|
2022-03-08T16:15:11.001Z
|
77,716,680 |
{
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"DOI": "10.4324/9781315767895-4",
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|
The Human Fertilisation and Embryology Act 2008 was a major update to the UK’s laws on the use and regulation of reproductive technology and assisted reproduction. Since the enactment of the new law, the sector’s regulatory body, the Human Fertilisation and Embryology Authority (HFEA), has also consulted on various related topics including barriers to egg and sperm donation in the UK, multiple births/single embryo transfer and using IVF technology to prevent mitochondrial disease.
This book critically considers recent developments in human fertilisation legislation, asking whether the 2008 Act has achieved its stated aim of being fit for purpose. Bringing together a range of international experts, the book evaluates the fresh risks and challenges emerging from both established and existing technologies and techniques in the field of human fertilisation and embryology, as well as offering valuable insights into the social and regulatory challenges that lie ahead. Key topics include problems with DIY assisted conception; the lack of reform in respect of the regulation of surrogacy arrangements; and mitochondrial DNA transfer.
As a review of the status of assisted reproduction legislation, this book will be of great use and interest to students, researchers and practitioners in medical law, bioethics, medicine and child welfare.
|
2022-09-16T08:05:55.366Z
|
91,082,388 |
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"DOI": "10.17707/AGRICULTFOREST.64.1.15",
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}
|
We evaluated the phenotypic stability and adaptability of spring barley varieties using the additive main effect and multiplicative interaction (AMMI) and genotype main effect (G) plus genotype-environment (GE) interaction (G+GE) biplot models. The research was conducted in five locations by randomized complete block design with three replications in each location in 2015-2016. The grain yields of all nine barley genotypes were significantly affected by environment, which accounted for 90.5% of the total variation, whereas genotype and genotype-environment interaction accounted for 4.0% and 5.5%, respectively. The AMMI and GGE biplot models reflected most of the variation caused by genotype and genotype-environment interaction effects in the first two principal components – 78.8% and 79.3%, respectively. The AMMI stability value (ASV) revealed that varieties Khors (G4) and Poduv (G5) were stable. GGE-biplot "which-won-where" showed that 9 environments used for the study belonged to 3 mega-environments with wining varieties Vzirets (G1), Inkliuziv (G6) and Dokaz (G9). According to the ideal genotype biplot, varieties Dokaz (G9), Inkliuziv (G6) and Khors (G4) were the best genotypes demonstrating high average yields and high stability of performance across the test locations. The results finally indicated that AMMI and GGE biplot were informative methods to explore stability and adaptation patterns of genotypes in practical plant breeding and in subsequent variety recommendations.
|
2022-11-04T20:37:00.348Z
|
230,598,892 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.18617/liinc.v16i2.5340",
"MAG": "3111316619",
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "http://revista.ibict.br/liinc/article/download/5340/5116"
}
|
Este artigo tem como objetivo refletir, com base na Sociologia da Ciência e na Ciência da Informação, sobre as condições de produção, divulgação e validação de enunciados, discursos e fatos científicos dentro e fora dos laboratórios. Em continuidade, pretendeu-se abordar a informação na sociedade contemporânea, apresentando as concepções de infodemia e desinformação, bem como apresentar as possíveis formas de mobilização dos indivíduos por meio das dimensões da competência em informação frente à pandemia da COVID-19. No que diz respeito aos procedimentos metodológicos, essa pesquisa se caracteriza quanto aos objetivos como exploratória, já no que se refere aos procedimentos, utilizou-se a pesquisa bibliográfica. A partir dos dados analisados, inferimos que a pandemia demonstrou que uma parcela significativa da população está vulnerável a infodemia e a desinformação. As fontes de informação institucionalizadas são o melhor canal de comunicação para reverter essa situação. Conclui-se que, torna-se cada vez mais urgente fomentar e implementar políticas informacionais voltadas para formação da competência em informação
|
2022-12-03T09:08:53.218Z
|
94,967,164 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1071/CH13081",
"MAG": "2039759393",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Advanced glycation end products (AGEs) were determined by a polyclonal ELISA method in three milk powders of varying lipid content, during storage in sealed containers at 65°C for up to 20 days. AGEs content correlated with increased water activity (aw), decreased glass transition temperature (Tg), increased lactose crystallisation, and browning in the three milk powders. Formation of stable radicals as detected by electron spin resonance spectroscopy correlated with crystallisation of lactose and brown discoloration in the three powders indicating origin from Maillard reactions rather than lipid oxidation. AGEs content was greatest in whole milk powder with highest lipid content, while in butter milk powder formation of secondary lipid oxidation products increased faster as determined by thiobarbituric acid reactive substances.
|
2022-02-10T15:56:54.319Z
|
72,766,515 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1159/000272604",
"MAG": "2058838457",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Die Standardbehandlung des fortgeschrittenen Ovarialkarzinoms besteht aus radikaler Primaroperation mit Debulking, eventueller retroperitonealer Lymphadenektomie sowie post-operativer Chemotherapie. W
|
2022-02-11T09:41:03.033Z
|
111,237,378 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1049/EL:19981148",
"MAG": "2079412198",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Reference LPN-ARTICLE-1998-004doi:10.1049/el:19981148View record in Web of Science Record created on 2008-02-29, modified on 2017-12-03
|
2022-02-10T04:26:35.328Z
|
86,708,142 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/01650420701411184",
"MAG": "2114031952",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Abstract A new species of Tupiperla, T. jumirim, is described from Chapada dos Veadeiros, northern Goiás State, Brazil. Kempnyia oliveirai is recorded from the same locality.
|
2022-02-10T22:06:44.237Z
|
133,848,844 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/cepa.712",
"MAG": "2805510936",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The research includes work on historical buildings, fortifications and cult monuments. Because of its diverse architectural and historical heritages, Albania offers plenty of research opportunities particularly in the repair of the geotechnical structures. A set of geological and geotechnical conditions will be analysed in order to comprehend conditions of two case studies placed in Peqini region. These are of significant importance according to their construction and for the fact that their closed contour foundations are present from the Romans period (in the Peqini castle) and constructed with limestone material brought from an older object (in the Clock Tower). Combination of type of structure and plain terrain geological characteristics are assessed. The goal is to contribute in the geotechnical assessment and revitalization of the case studies selected as objects with value for the community and for the field of geotechnical maintenance. Ultimately, this fosters a better appreciation of the historical heritage in Albania through the understanding of their geotechnical predictions reliability.
|
2022-07-11T01:02:58.464Z
|
12,413,945 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1177/074823379601200318",
"MAG": "2110402999",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Epidemiological studies of exposed human populations can provide valuable evidence of human health effects. Information has been sparse on human health effects associated with consumption of contaminated Great Lakes fish. As part of its Great Lakes Human Health Effects Research Program, the Agency for Toxic Substances and Disease Registry (ATSDR) has funded ten projects. Of these studies, eight are epidemiologic investigations of human exposure and potential health effects from consumption of contaminated fish. To strengthen and to enhance the findings and comparability across the health studies, ATSDR has initiated several activities. These activities include harmonizing questionnaires, analytical protocols, human health end points, and contaminants tested. Also included is the establishment of a quality assurance and quality control (QA/QC) program and tissue bank. These activities will allow ATSDR to enhance exposure assessment in the Great Lakes basin. In addition, these research activities allow ATSDR to evaluate and to interpret data across all the projects, including a basin-wide health risk analysis on exposure, levels of contaminants or body burden, and the potential for human health effects from exposure to Great Lakes contaminants.
|
2022-09-04T12:32:57.479Z
|
135,831,046 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1117/12.965628",
"MAG": "2072616541",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Diffraction gratings on the surfaces of optical substrates have been demonstrated to perform functions such as beam sampling and infrared polarization. These surface gratings are defined by holographic exposure and ion beam sputter etched into a gold layer on the substrate. The patterns can be designed with spatially varying periods to provide optical power in the diffracted beam and they can cover large areas on flat or non-flat surfaces. High grating accuracy and edge definition result in improved performance when compared to conventional fabrication techniques.
|
2022-11-25T19:09:44.051Z
|
199,173,849 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.22492/IJMCF.1.1.06",
"MAG": "2957794184",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In Indonesia, there is a growing trend to open businesses through social media, especially by women. There are many reasons that account for this trend, the main reason being the flexibility that it affords businesses, allowing transactions to be done from anywhere, including one’s own home. This paper argues that online business has great potential in empowering women by assisting them to become entrepreneurs. Online businesses can also be seen as a solution to the dilemma faced by women who must manage and balance their career and family life. Ultimately, social media entrepreneurship works well for women in Indonesia due to its unique characteristics that include: mobility and flexibility, social capital gained through social media interactions, the unequal distribution of products in Indonesian cities, the lack of time on the part of customers to visit physical shops and the confidence and satisfaction experienced by women as a result of this enterprise.
|
2022-12-16T09:52:02.388Z
|
226,814,117 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.21608/ajar.2019.102951",
"MAG": "3044122637",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://ajar.journals.ekb.eg/article_102951_aa93b389ebfb981b7f10d07a5fb296d5.pdf"
}
|
The industry adds antioxidants in the formulation of meat products to prevent or delay meat oxidation reactions. Therefore, this investigation was carried out to study the effect of normal essential oil and loaded-solid lipid nanoparticles as antioxidants and the effect of the abovementioned volatile oils on chemical properties (TBA) and shelf life of frozen beef burger. The antioxidant activity of volatile oils (cinnamon and ginger) normal and nano particle size at different concentrations were assessed. Also, the effect of the above mentioned volatile oils addition with different concentrations on chemical properties and shelf life of frozen beef burger was investigated. Results indicated that, the diphenylpicrylhydrazyl free radical scavenging activity increased by increasing the volatile oil concentrations for all studied treatments. Moreover, the antioxidant activity of volatile oils (cinnamon and ginger) nanoparticles was higher than that of the same concentrations of normal volatile oil. The chemical properties values thiobarbituric acid value (TBA) of beef burger decreased by increasing volatile oils concentrations and essential oils nanoparticles reduced chemical properties (TBA) values more than normal essential oils, beside extending the shelf life of beef burger treatments up to 6 months in comparison with control sample which have a four-month shelf life. In conclusion, the transformation of essential oils into nanoparticle size can affect their antioxidant activity and promote the chemical properties and shelf life of beef burger.
|
2022-12-17T07:06:35.287Z
|
205,259,922 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/adma.201500329",
"MAG": "2171902254",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "https://europepmc.org/articles/pmc4418194?pdf=render"
}
|
Electrospun nanofibers with controllable degrees of crimping are fabricated by simply exposing the samples to a plasticizer at preset shrinkage ratios. Compared with their straight counterparts, the crimped nanofibers are able to mechanically mimic native tendon tissue and better protect tendon fibroblasts under uniaxial strains.
|
2022-12-19T20:48:53.958Z
|
120,751,746 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1364/JOSAA.11.000325",
"MAG": "1976730120",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The Kolmogorov theory is used to illustrate that the mean-square wave-front error E2, which results when the wave-front distortion associated with an artificial guide-star reference is used to compensate a telescope aperture of diameter D, for imaging an object at infinity is given by E2 = (D/d0)5/3. The quantity d0 is a measure of the effective diameter of the compensated imaging system (i.e., a telescope with a diameter equal to d0 will have 1 rad of rms wave-front error) and is expressed as an integral over the Cn2 profile. The Cn2-weighting function is expressed in terms of hypergeometric functions whose series representation converges very rapidly. (Typically only a few terms are required). As a result d0 can be evaluated quite quickly on a microcomputer or a scientific calculator. In this study the quantity d0 is evaluated for six Cn2 profiles of interest, illustrating the importance of including the altitude weighting in the theoretical formulation of d0. In addition, this study illustrates the importance of removing the piston and the tilt from the wave-front distortion when assessing the performance of an imaging system.
|
2022-12-23T07:27:44.488Z
|
16,616,766 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1364/JOCN.7.000286",
"MAG": "2123077770",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Wavelength routing based on arrayed waveguide grating (AWG) devices has been proposed as a disruptive technology for capacity, footprint, and flexibility requirements of cloud data centers. The limited buffering capacity of AWG-based routers, however, affects network throughput and makes them highly susceptible to data center traffic imbalance. A load-balancing stage, capable of evenly distributing the incoming traffic in both space and time, can improve network robustness and remedy congestion penalties. Robustness and scalability due to load balancing come at the cost of physical-layer complexities in terms of added cost, power consumption, and impairments. In this paper, we conduct a novel scalable analysis to study load-balancing tradeoffs between network-layer gains and physical-layer penalties in a multistage routing scenario. Our cross-layer simulations examine the requirements of a wavelength-routing load balancer based on AWG and tunable wavelength converters (TWCs) in order to achieve performance interesting for a data center. Our results point to the critical contribution of Q-factor degradation to load-balancer performance and encourage efforts in the design of novel router architectures, aiming to consolidate routing with scheduling-based load balancing.
|
2022-12-24T11:22:07.031Z
|
110,399,817 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2514/6.2010-7721",
"MAG": "2042445606",
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
This paper describes a conceptual design of the Thrust Vector Control (TVC) system and preliminary modeling of propellant slosh, for the Altair Lunar Lander. Altair is a vehicle element of the NASA Constellation Program aimed at returning humans to the moon. Guidance, Navigation, and Control (GN&C) is the measurement and control of spacecraft position, velocity, and attitude in support of mission objectives. One key GN&C function is the commanding of effectors that control attitude and impart ∆V on the vehicle, utilizing both reaction control system (RCS) thrusters and throttling and TVC gimbaling of the vehicle main engine. Both the Altair descent and ascent modules carry fuel tanks. During thrusting maneuvers, the sloshing of liquid fuels in partially filled tanks can interact with the controlled system in such a way as to cause the overall system to be unstable. These fuel tanks must be properly placed, relative to the spacecraft’s c.m., to avoid any unstable interactions. Following this will be a discussion of propellant slosh modeling work performed for the present vehicle configuration, including slosh frequency and participatory fluid mass predictions. Knowing the range of slosh mode frequencies over mission phases, the TVC bandwidth must be carefully selected so as not to excite the slosh modes at those frequencies. The likely need to increase the damping factor of slosh modes via baffles will also be discussed. To conclude, a discussion of operations procedures aimed at minimizing TVCslosh interactions will be given.
|
2022-12-28T20:45:46.999Z
|
150,992,762 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1136/BMJEBM-2018-111070.132",
"MAG": "2914925160",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Background Competing interests among patient decision aid authors have potential to undermine the usefulness of these tools for supporting patients to make informed and values-concordant health decisions. Competing interests may also contribute to overdiagnosis and overtreatment. Prevailing decision aid quality standards attempt to counteract the potential effects of competing interests by advocating disclosure. However, we know little about how decision aid users perceive and respond to competing interest disclosure statements and thus, whether this approach is sufficient. This poster will describe the protocol for a forthcoming experimental study designed to better understand users’ perceptions of and reactions to competing interest disclosure statements in patient decision aids. Methods Approximately 360 English-speaking adults in the United States will be recruited to participate in an online survey using a commercial panel service. Recruitment quotas will be imposed so that the final sample is composed equally of participants with adequate and limited health literacy. During the survey, participants will be asked to ‘Imagine that you have been told by a doctor that you have a rare and serious strain of the flu called Elephant Influenza’ and will be randomised to receive advice that either ‘While searching online, you find this decision aid on treatment options for Elephant Influenza’ or ‘While in the clinic, your doctor gives you this decision aid on treatment options for Elephant Influenza’. Participants will then be randomised to view a brief fictional patient decision aid on treatment options for Elephant Influenza that features one of three different competing interest disclosure statements (disclosure of no competing interests, disclosure of competing interests, disclosure of competing interests with additional cautionary statement about the bias competing interests can introduce) and asked several closed and open-ended questions. Analysis and dissemination Data analysis will address four primary research questions: (1) how frequently do decision aid readers notice, remember, and understand author competing interest disclosure statements in a patient decision aid, and does this depend on type of disclosure statement? (2) what is the effect of type of disclosure statement on decision aid readers’ perceptions of the trustworthiness of the decision aid, their (hypothetical) treatment choices, and their perceptions of the values concordance of their (hypothetical) treatment choices? (3) is the effect of type of disclosure statement on perceived trustworthiness, treatment choices, and perceived values concordance moderated by the (imagined) mode of delivery of the decision aid? and (4) how unnecessary, informative, patronizing, and important do decision aid readers perceive disclosure statements to be, and does this depend on type of disclosure statement? Study results will be disseminated widely and inform understanding of the adequacy of current approaches to managing competing interests among patient decision aid authors.
|
2022-02-09T03:36:20.301Z
|
229,481,227 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1093/ehjci/ehaa946.0194",
"MAG": "3110519608",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Data on changes in left atrial (LA) and left ventricular (LV) volumes after transcatheter mitral valve replacement (TMVR) are limited.
This study sought to describe the anatomical and functional changes in left-sided cardiac chambers by computed tomography angiography (CTA) from baseline to 1-month after TMVR with Tendyne prosthesis.
We analyzed patients who underwent TMVR with Tendyne prosthesis (Abbott Structural, Menlo Park, CA) between 2015 and 2018. Changes in LV end-diastolic volume (LVEDV), ejection fraction (LVEF), mass (LV mass), LA volume and global longitudinal strain (GLS) were assessed at baseline and at 1-month after TMVR with CTA. Specific Tendyne implant characteristics were identified and correlated with remodeling changes.
A total of 36 patients (mean age 73±8 years, 78% men, 86% secondary MR) were studied. There were significant decreases in LVEDV (268±68 vs. 240±66ml, p<0.001), LVEF (38±10 vs. 32±11%, p<0.001), LV mass (126±37 vs. 117±32g, p<0.001), LA volume (181±74 vs. 174±70 ml, p=0.027) and GLS (−12.6±5.1 vs. −9.5±4.0%, p<0.001) from baseline to 1-month follow-up. Favorable LVEDV reverse-remodeling occurred in the majority (30 of 36 patients, or 83%). Closer proximity of the Tendyne apical pad to the true apex was predictive of favorable remodeling (pad distance: 25.0±7.7 vs. 33.5±8.8mm, p=0.02 for those with and without favorable remodeling).
TMVR with Tendyne results in favorable left-sided chamber remodeling in the majority of patients treated, as detected on CTA at 1-month after implantation. CTA identifies the favorable post-TMVR changes, which could be related to specific characteristics of the device implantation.
Type of funding source: None
|
2022-02-07T22:56:08.803Z
|
71,672,693 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3329/BDJPS.V1I1.6488",
"MAG": "1995720629",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Background: Hair transplantation is one of the most evolving procedures in aesthetic surgery accompanied by regular improvement in technique. The recent advancement in technology and the concept of using follicular unit grafts have made this procedure reach a new height. A precise appreciation of anatomy has allowed the use of follicular unit graft. With better methods of harvesting and implantation, hair transplantation results represent a blend of art and science. Materials & method: 60 patients underwent hair transplant surgery from July/2008 to June/2009. Age limit was 18-58 years. Patients were evaluated and prepared in standard way. Operations were done by Robotic follicular unit graft by a specially designed machine. Procedures were performed under nerve block and local infiltration .Grafting sessions lasted for 5-6 hours, during which 1500-2000 FUGs were transplanted. Patients were discharged on the same day. Results: Minimum complications were observed. Most of the patients were satisfied except a few. Some patients needed second sitting surgery. Conclusion: With better methods of harvesting and implantation, Hair transplantation, if done judiciously, is a very rewarding procedure, both for the surgeon and the patient. DOI: http://dx.doi.org/10.3329/bdjps.v1i1.6488 Bangladesh Journal of Plastic Surgery (2010) Vol. 1 (1) pp.19-23
|
2022-12-18T03:58:07.163Z
|
974,003 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1177/0891988714522701",
"MAG": "2017127671",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Montreal Cognitive Assessment (MoCA) is a new cognitive tool developed for screening mild cognitive impairment (MCI). The authors examined validity of MoCA and discriminating power of subtests in a Turkish population comprising of 474 participants (246 healthy controls, 114 subjects with MCI and 114 subjects with dementia). The ANCOVAs showed that age and education had a main effect on MoCA scores. Cut scores were computed according to different education levels. The overall cut-off values for MCI and dementia were found to be lower compared to western studies. MoCA was found to have good internal consistency. The subtests most useful in discriminating MCI from healthy controls were recall, visuospatial and language, while in discriminating dementia from MCI were visuospatial, orientation and attention subtests. The results demonstrated that MoCA is a valid and reliable instrument in screening MCI, and compared with the MMSE, MoCA was proved to have superior sensitivity and specificity in detecting MCI.
|
2022-12-19T08:07:32.353Z
|
6,616,014 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1159/000474753",
"MAG": "2417538113",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Antegrade urethroscopy was performed through a cystostomy using a 10.8-fr caliber flexible renoureteroscope in 4 children (aged 2 years and 8 months, 2 months, 14 years and 1 month) with anterior urethral valve. The anatomy of the valves as well as their destruction after transurethral resection (TUR) were well visualized by antegrade urethroscopy. This technique was helpful in performing TUR-valve, after which the findings of voiding cystourethrography in every case and the findings of uroflowmetry in the elder 2 cases showed remarkable improvement. This technique is relatively simple to perform and is thought to be one of the best methods to treat anterior urethral valve. This technique is also applicable to other lower urinary tract lesions in children.
|
2022-04-07T22:44:58.570Z
|
5,020,877 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1093/aje/kwn389",
"MAG": "2171569521",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://academic.oup.com/aje/article-pdf/169/6/769/201667/kwn389.pdf"
}
|
The authors used data from a nationally representative survey of 933 adults aged 54 years or older (mean age = 66.2 years; standard deviation, 8.0) in Taiwan to explore whether mortality prediction at older ages is improved by the use of 3 clusters of biomarkers: 1) standard cardiovascular and metabolic risk factors; 2) markers of disease progression; and 3) nonclinical (neuroendocrine and immune) markers. They also evaluated the extent to which these biomarkers account for the female advantage in survival. Estimates from logistic regression models of the probability of dying between 2000 and 2006 (162 deaths; mean length of follow-up = 5.8 years) showed that inclusion of each of the 3 sets of markers significantly (P = 0.024, P = 0.002, and P = 0.003, respectively) improved discriminatory power in comparison with a base model that adjusted for demographic characteristics, smoking, and baseline health status. The set of disease progression markers and the set of nonclinical markers each provided more discriminatory power than standard risk factors. Most of the excess male mortality resulted from the men being more likely than women to smoke, but each of 3 markers related to disease progression or inflammation (albumin, neutrophils, and interleukin-6) explained more than 10% of excess male mortality.
|
2022-12-23T08:12:45.203Z
|
44,181,798 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1177/0142723711409976",
"MAG": "2163409996",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This study proposes a new methodology for determining the relationship between child-directed speech and child speech in early acquisition. It illustrates the use of this methodology in investigating the relationship between the morphological richness of child-directed speech and the speed of morphological development in child speech. Both variables are defined in terms of mean size of paradigm (MSP) and estimated in a set of longitudinal spontaneous speech corpora of nine children and their caretakers. The children are aged 1;3–3;0, acquiring nine different languages that vary in terms of morphological richness. The main result is that the degree of morphological richness in child-directed speech is positively related to the speed of development of noun and verb paradigms in child speech.
|
2023-01-01T21:02:56.075Z
|
224,988,417 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.15593/perm.mech/2020.2.06",
"MAG": "3046269142",
"PubMedCentral": null
},
"license": "CCBYNC",
"status": "HYBRID",
"url": "https://ered.pstu.ru/index.php/mechanics/article/download/731/477"
}
|
We developed a three-dimensional numerical model of a piezoelectric luminescent optical fiber sensor fixed on a composite’s plate. The computational region of the sensor is the optical fiber with two concentric (with 6 sectors) shells of electroluminescent and piezoelectric materials, two control electrodes on interface surfaces, such as optical fiber-electroluminophore and piezoelectric-cover. The external sensor’s cover is made in the form of a semi-elliptic cylindrical polymer shell, which rectangular base is fixed on the surface of the fiberglass plate. In the piezoelectric shell sectors, the polarization directions of the PVDF transversal-isotropic polymer piezoelectric are different and non-planar for any three sectors. Deformation of the plate causes deformation of the sensor fixed on its surface, as well as the occurrence of informative piezoelectric fields in it, thus the occurrence of informative glows of electroluminescent elements. As a result, we find the requested information about the combined deformed state of the composite plate along the length of the sensor based on the digital processing of the integral intensities of the polychrome light signals at the output of the optical fiber. In simple cases of electric and mechanical loads, we present new numerical results of simulating the distribution of non-uniform electroelastic fields in the sensor multiphase volume, the sensor’s external cover and inside fragment of the composite plate. Loading of the sensor-covering-plate system is performed by controlling electric voltage on the sensor’s electrodes and the plate’s mechanical deformation by stretching along the transverse and longitudinal axes, as well as by twisting around these axes and bending in transverse and longitudinal planes. Numerical values of the control and informative transfer coefficients of the piezoelectric luminescent optical fiber sensor are determined, which makes it possible to perform a reliable and high-precision diagnostics of complex deformations of the composite plates and design sensors of this type.
|
2022-01-27T08:31:38.490Z
|
2,672,900 |
{
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"DOI": "10.5507/bp.2014.032",
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"license": "CCBY",
"status": "GOLD",
"url": "http://biomed.papers.upol.cz/doi/10.5507/bp.2014.032.pdf"
}
|
BACKGROUND
P-glycoprotein (P-gp/MDR1), a member of the ATP-binding cassette (ABC) transporters super family, encoded by the ABCB1/MDR1 gene, is one of suggested respiratory tract protection components, found in various tissues with a barrier function, such as tracheobronchial epithelium and lung parenchyma. As an ATP-dependent pump, P-gp extrudes lipophilic particles out of cells and acts as a gatekeeper against numerous xenobiotics, with a protective role in mediating DNA damage, secretion of toxic compounds, apoptosis and the immune response. Therefore, a presence of MDR1 polymorphisms and altered P-gp expression may be important for pathogenesis of reduced lung inflammatory response on cigarette smoke exposure, as well as for the severity of chronic obstructive pulmonary disease and lung cancer pathogenesis and treatment efficacy.
METHODS AND RESULTS
We have analyzed data available from experimental and clinical studies performed to establish the role of MDR1 polymorphisms, especially the 3435C>T variation, and P-gp expression in pathogenesis and clinical outcome of human respiratory diseases.
CONCLUSIONS
Although there are indications that altered expression of P-gp and/or polymorphisms of MDR1 gene play an important role in respiratory diseases pathogenesis and treatment, their exact role and relevance are insufficiently investigated, with exception of certain chemotherapeutic agents' efficacy in lung cancer treatment. Further research in this field, including bigger series of patients, is necessary for better understanding of respiratory diseases' pathogenesis and treatment.
|
2022-09-02T09:42:45.990Z
|
252,900,248 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/ICDSIS55133.2022.9915954",
"MAG": null,
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"license": null,
"status": null,
"url": null
}
|
Machine learning (ML) is trending knowledge tool for finding disease. It facilitates systems that can learn data automatically. Breast cancer (BC) is second largest disease among the women. In all over world 50 % women are dying due to the BC. ML is used in finding the results in BC as malignant or benign because predication of BC at early stage is going to be very challenging. This proposed work is to identify the BC disease before time stage with the help of machine learning algorithms viz. K-Nearest Neighbor, Random Forest, Naive Bayes, Support Vector Machine (SVM) & Decision Tree. Herein projected work, the dataset used has been collect from the UCI repository. In Breast cancer dataset Out of total 450 samples, 150 samples are found either benign or malignant. The results obtained to achieve higher performance measures show that RF gives best outcome by smallest amount inaccuracy rate.
|
2022-10-18T19:26:07.953Z
|
6,113,976 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.4238/gmr.15038206",
"MAG": "2512954480",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://doi.org/10.4238/gmr.15038206"
}
|
Head and neck squamous cell carcinoma (HNSCC) has become one of the most common forms of cancer worldwide. Hypermethylation-induced silencing of tumor-associated gene has been proposed as an important cofactor in cancer pathology. This paper aimed to characterize the gene methylation patterns in human papillomavirus (HPV) associated-HNSCC. TIMP3 and APC methylation status in neoplastic (N = 92) and non-neoplastic tissues (N = 92) of HNSCC as well as their association with HPV infection were investigated via methylation-specific PCR assays. Results indicated that methylation level of TIMP3 was markedly higher in HPV-positive tumors as compared with HPV-negative tumors. Both TIMP3 and APC methylation were associated with lymph node metastasis and higher clinical stage of tumors. Patients with methylation at TIMP3 or APC had worse prognoses as compared to those without these alterations. This is the first study that shows a possible linkage between HPV infection and APC methylation. Methylation patterns of tumor-related genes may contribute to different disease prognosis in HNSCC according to the HPV infection status.
|
2022-11-18T17:01:06.958Z
|
254,526,946 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.52420/2071-5943-2022-21-6-89-94",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBY",
"status": "HYBRID",
"url": "https://umj.usma.ru/jour/article/download/1127/935"
}
|
Introduction. Primary cell cultures of breast carcinoma (BC) are used as a model for study the processes of intratumoral heterogeneity, drug resistance and various molecular and biological processes. One of the variants of primary culture is non-adhesive cell culture in the form of spheroids – mammospheres. There is evidence that cells isolated from mammospheres have mesenchymal features. However, the acquisition of mesenchymal features in mammospheres derived from tumors correlates with suppression of estrogen receptor expression and, therefore, with resistance to therapy against hormone-dependent tumors.The aim of the study was to determine the effect of the method of culturing BC cells on the ability of cells to preserve the epithelial phenotype.Materials and methods A comparative analysis of two BC culture samples examined over three passages using different methods of cultivation was performed. Staining for morphological evaluation was carried out according to Pappenheim. Determination of belonging to epitheliocytes was performed using anti-Pan Keratin (AE1/AE3/ PCK26) Primary Antibody (Roche diagnostics, USA).Results Three passages (P2, P3, P4) of non-adherent and three passages of adherent cells were taken for culture analysis. During the study of these BC culture variants, the morphological features of the cells in each passage were determined and it was found that regardless of the technique chosen during cultivation, the cells of the cultures under study retained the epithelial phenotype. However, the study of the adhesive culture revealed a higher percentage of cells showing the epithelial phenotype compared to the cells of the non-adhesive culture.Discussion In the course of our study, six morphological groups of cells obtained during the creation of a primary culture of a BC sample were identified, among which differences in the preservation of the epithelial nature throughout the cultivation were manifested.Conclusion The choice of cultivation technique influences the ability of cells to retain the epithelial phenotype for three passages. In the second passage, the level of pancytokeratin expression in the adhesive culture is significantly differed from that in the non-adhesive culture. By the fourth passage there is a sharp decrease in the number of epithelial cells.
|
2022-12-16T15:18:17.125Z
|
168,242,381 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1108/IJSMS-14-02-2013-B002",
"MAG": "2463461808",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This study surveys professional niche sports sponsors in an effort to empirically understand what selection criteria these companies deem important when evaluating professional niche sports sponsorship proposals. Findings suggest that professional niche sports properties may possess unique attributes on which sponsors place very high levels of importance, such as cost effectiveness, flexibility in assisting sponsors achieve their objectives, a more targeted fan-base and decreased sponsorship clutter. Pragmatically, findings provide professional niche sports managers with tools that may be useful when competing for sponsorship funding against more established mainstream sports properties. Theoretically, the current study begins to fill a gap in the sports sponsorship literature which has primarily focused on mainstream professional sports, major intercollegiate sports and elite amateur sports such as the Olympic Games.
|
2022-12-16T20:44:09.384Z
|
170,370,557 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.15181/RH.V0I14.755",
"MAG": "2202424927",
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},
"license": null,
"status": null,
"url": null
}
|
This article is dedicated to study of archetype of faith in the text by Vladimir Korotkevich “Christ has landed in Grodno” (1996). Archetype of faith is an ontological component of the novel’s artistic world, by which the author forms a system of spiritual and material values of heroes in his work. The text represents both the traditional (Christian) idea of true faith that has existed for centuries, and the new one that is implemented in the neo-myth of Korotkevich in the XX century. The power in Grodno propagates the idea about faith, which is associated with enslavement of Byelorussians, violence and dictatorship. Rebels, who are striving for freedom in Belarus, asserting the rights of a Human in the society of Grodno that is not free, see the faith as love, good, confidence and devotion.KEY WORDS: faith, Christianity, humility, the Middle Ages, the Renaissance, liberty, love.
|
2022-02-08T17:22:57.813Z
|
109,066,863 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1055/S-2004-813364",
"MAG": "1966415517",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Die Beurteilung von Gesundheitssystemen ist kein einfaches Unterfangen. Das zeigen sowohl die aktuelle Debatte, 100 Tage nach Einfuhrung der Gesundheitsreform in Deutschland, als auch die internationale Diskussion. Im Weltgesundheitsbericht 2000 hat die WHO 191 Gesundheitssysteme dieser Welt beurteilt und in einer Weltrangliste aufgereiht. Die Ergebnisse haben gerade in den Industrienationen einiges Befremden ausgelost. Ziel der Studie ist es, die unterschiedlichen Beurteilungen von Gesundheitssystemen durch Experten und Laien herauszuarbeiten. Hierzu werden die Einschatzungen der WHO mit den Wahrnehmungen der Menschen, die in 17 Industrielandern leben und diese Systeme taglich nutzen bzw. erleben, verglichen (Methodik). Die Ergebnisse zeigen nur geringe Ubereinstimmungen. Einige WHO-Spitzenreiter werden von der eigenen Bevolkerung sehr kritisch beurteilt (z. B. Italien, Spanien) und umgekehrt (z. B. Danemark, Finnland). Eine Schlussfolgerung daraus ist, dass bei der Beurteilung von Gesundheitssystemen nicht nur Expertenmeinungen, sondern auch die Einschatzungen der Nutzer dieser Systeme („Offentlichkeit”) berucksichtigt werden sollten. Beide Beurteilungen liegen auch in der aktuellen Reformdiskussion in Deutschland weit auseinander. The assessment of health systems is a bold venture. Both, Germany's debate about the actual reform's strengths and areas of improvement as well as WHO's approaches to the assessment of health systems in 191 countries are continuously discussed. The latter was mainly based on measures from public health experts. It was introduced in the World Health Report 2000 and had an immediate impact. The goal of this paper is to compare the WHO rankings (indicator approach by “experts”) for seventeen industrialised countries with the perceptions of their citizens (questionnaire approach by “non-experts”) (methodology). The results show little relationship between WHO assessments and the satisfaction of the citizens who experience these health systems. Some WHO top performers are rated poorely by their citizens e. g. Italy and Spain. The two rated most highly by the public: Denmark and Finland, rank at the bottom of the WHO assessments. The same situation occurs in Germany: politicians as well as public health experts applaud the recent reforms whereas the public is unsatisfied about it. These findings suggest that both public perceptions and expert views should be considered in health system assessments (conclusion).
|
2022-02-10T06:38:54.832Z
|
79,899,016 |
{
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"DOI": "10.18869/ACADPUB.JNKUMS.9.1.55",
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"license": null,
"status": null,
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|
Background & Objectives: Tuberculosis is a bacterial disease that gets created by Mycobacterium Tuberculosis. Pulmonary tuberculosis constitutes more than 80% of the Tuberculosis cases. Despite the availability of effective treatment for pulmonary TB, sputum smear negative time course of patients affected by various factors is not as expected. The aim of this study was to examine the factors affecting patient’s in North Khorasan province. Material and Methods: It is a historical cohort study, in which all of the smearpositive pulmonary TB cases in North Khorasan province from 1384 to 1393 were enrolled. Information of patients was extracted from the software for patients’ registration, as well as registered documents TB available in the health centers. The relationship between negative sputum smears time course and effective factors was determined by ordinal regression and with the outcome of the treatment was determined by multiple linear regression. Results: At the end of the second month of treatment, sputum smear negative rate was 72.6%. Addiction in people increased the chance of negative sputum smear at the end of sixth month (OR: 3.151) (p = 0.034). Basil density also had a significant correlation with sputum smear negative duration (p<0.001). Conclusion: The findings showed that the negative sputum smears time course for patients at the end of the second month of treatment, was not get the expected amount of treatment for TB patients in the study population.
|
2022-02-11T03:36:21.152Z
|
23,787,514 |
{
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"DOI": "10.3760/CMA.J.ISSN.1002-0098.2013.11.004",
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|
OBJECTIVE
To investigate the regulatory mechanisms of integrin α5 and β1 in osteoblast in the process of gingipains-induced apoptosis.
METHODS
Gingipains were isolated and purified from supernatants of Porphyromonas gingivalis W83 which was cultured under standard anaerobic conditions. MC3T3-E1 was challenged with or without 8.3480 U/L gingipains for 48 h and apoptosis was examined by transferase-mediated deoxyuridine triphosphate-biotin nick end labeling-(4-Amidinophenyl)-6-indolecarbamidine dihydrochloride (TUNEL-DAPI) staining. The expression of integrin α5 and β1 was analyzed by Western blotting after MC3T3-E1 was treated under different conditions.
RESULTS
Arginine-specific proteinases(Rgp) activity was (41.74 ± 2.11) U/L and lysine-specific proteinase(Kgp) was (1.02 ± 0.25) U/L.Gingipains induced MC3T3-E1 cells apoptosis after 48 h. Compared with control group, expression of integrin α5 and β1 was down-regulated by gingipains in a time-dependent manner within short periods ( ≤ 72 h), integrin α5 and β1 relative expression was (0.485 ± 0.039),(0.504 ± 0.002) at 48 h,(0.398 ± 0.058),(0.179 ± 0.001) at 72 h respectively (P < 0.05). After 72 h, integrin α5 expression in MC3T3-E1 cells was stable compared with control group while integrin β1 was still lower(control group:1.000 ± 0.000, 96 h:0.604 ± 0.003, 120 h: 0.357 ± 0.002) (P < 0.05). Proteinase inhibitor tosyl- L- lysine-chloromethyl-ketone(TLCK) effectively blocked the activity of gingipain and inhibited down-regulation of integrin α5 and β1 induced by gingipains from (0.398 ± 0.058,0.179 ± 0.001 ) to (0.781 ± 0.012, 0.857 ± 0.060) (P < 0.05). TLCK alone did not have any effect on integrin α5 and β1(P > 0.05). Gingipains also decreased integrin α5 and β1 in a dose-dependent manner.When cells were treated with 20.8700 U/L gingipains, integrin α5 and β1 relative expression reached to the lowest(0.105 ± 0.004,0.020 ± 0.000) (P < 0.05).
CONCLUSIONS
Gingipains inhibited the expression of integrin α5 and β1 in a time- and dose- dependent manner in osteoblasts in the process of apoptosis, which may not be mediated by direct proteolytic effect.
|
2022-02-12T19:06:41.499Z
|
84,052,977 |
{
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"DOI": "10.1179/174328209X431259",
"MAG": "1974341731",
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"url": null
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|
China has a rich moss flora and the genus Entodon is well represented (Hu, 1983). However, in the last revision of the genus for the region, Hu (1983) described a new species, Entodon acutifolius, from Yunnan, and placed it in subgenus Entodon. The distinguishing characters of subgenus Entodon are a yellow seta and a lack of annular differentiation [as opposed to a red seta and a well-developed annulus in subgenus Erythropus (Broth.) Mizush. (Buck, 1980)]. When we re-examined the material of Entodon acutifolius, it was found that the characters of this species were in conflict with Hu’s (1983) original description, in that E. acutifolius lacks an annulus, and the seta is reddish. Through a recent revision of Entodon in East Asia by the first author, we were provided with an opportunity to examine the type specimen of E. acutifolius, which is housed at PE. After a detailed examination of the type material, we realized that E. acutifolius is best placed in the synonymy of Platygyriella aurea (Schwägr.) W. R. Buck, on the basis of the decurrent ovate-lanceolate leaves, strongly bordered exostomial teeth, and a relatively high endostomial basal membrane. Platygyriella aurea (Schwägr.) W.R. Buck Brittonia 36: 86. 1984. (Figs 1, 2) Neckera aurea Schwägr., Sp. Musc. Frond., Suppl. 3(1): 217b. 1827; Pterogonium aureum Hook., Musci Exot. 3: 147. 1819, hom. illeg.; Pterigynandrum aureum Steud., Nomencl. Bot. 2: 355. 1824, hom. illeg.; Maschalocarpus aureus (Schwägr.) Spreng., Syst. Veg. 4(1): 160. 1827; Anomodon aureum (Schwägr.) Fürnr., Flora 12(2): 46. 1829; Leskea aurea (Schwägr.) Harv., J. Bot. (Hooker) 2: 16. 1840; Stereodon aureus (Schwägr.) Mitt., J. Proc. Linn. Soc., Bot. Suppl. 1: 94. 1859; Entodon aureus (Schwägr.) A. Jaeger, Ber. Thätigk. St. Gallischen Naturwiss. Ges. 1876– 77: 293. 1878; Cylindrothecium aureum (Schwägr.) Paris, Index Bryol. 295. 1894; Pylaisia aurea (Schwägr.) Broth., Nat. Pflanzenfam. 1(3): 886. 1907; Bryosedgwickia aurea (Schwägr.) M. Fleisch., Hedwigia 63: 211. 1922. TYPE: Nepal. D. Gardner s.n. (isotype: NY!) Entodon acutifolius R.L. Hu, Bryologist 86: 206, figs. 23– 30. 1983, syn. nov. TYPE: China. Yunnan Prov., Yang 326 (holotype PE!). Plants slender to medium-sized, yellowish-green, glossy, in soft mats. Stems prostrate, to 6.0 cm long, subpinnately branched; branches simple, short, to 1.8 cm long, terete-foliate, attenuate; in cross-section nearly round, with 2–4 rows of small, thick-walled, colored cells, internally with large, thin-walled cells, central strand none; pseudoparaphyllia foliose. Stem leaves ovate-lanceolate, 1.2–1.460.4–0.6 mm, concave, acute to acuminate, shortdecurrent; margins plane, entire; costae double, very short; median leaf cells linear, 45.0–70.064.0–5.0 mm, smooth; alar cells numerous, quadrate, extending up leaf margins by 10–15 cells, usually not extending to costae at leaf base, group triangular in outline, cells of narrow decurrencies larger in 1–2 rows and extending downward by 4–6 cells. Branch leaves similar to stem leaves but slightly smaller, 1.0–1.260.3–0.4 mm. Autoicous. Perichaetia on stems; inner perichaetial leaves oblong-lanceolate, acuminate, ca. 1.8 mm long, ecostate. Setae reddish, 1.5–1.8 cm long; capsules erect, cylindrical, reddish-brown, 2.0–2.560.7– 0.8 mm; annulus absent; operculum short-rostrate, straight to oblique; peristome attached slightly below mouth, double; exostome teeth lanceolate, strongly bordered, to 0.3 mm long, cross-striolate in basal 5–6 plates, becoming papillose to obliquely striolate at middle, and smooth above, yellowish-brown, back surface smooth or slightly papillose; endostome with a fairly high (3–5 cells) basal membrane, segments narrow, smooth, slightly shorter than teeth. Spores 12.0–30.0 mm in diam., finely papillose. Distribution: China, Nepal, Bhutan, and India. Illustrations: Figs 1, 2; Gangulee (1980: 1939, fig. 993). Selected specimens examined: China. NEI MONGOL: Gao 3424 (IFSBH); SICHUAN: Gao 20099, Zhang et al. 21516 (both IFSBH); YUNNAN: Li 80–74 (HKAS), Yunnan Univ. Biol. Dept. 0928 (YUKU), Zang 5698 (HKAS). Nepal. Miehe 15192A (NY). India. Bahariu 334, Gollan 3346, Gollan 6057, Mohindan 65, Rhan s.n. (all NY). Platygyriella aurea, a species of Hypnaceae, is characterized by terete-foliation; absence of a central strands in stems; ovate-lanceolate leaves with acute to narrowly acuminate apices and short, narrow decurrencies; peristome inserted below mouth; exostome teeth strongly bordered; and a relatively high endostomial basal membrane. Bryosedgwickia, a generic synonym of Platygyriella (Buck, 1984), was based on a single Indian species, described by Cardot and Dixon (in Dixon, 1912), and was assigned to Entodontaceae. However, decurrent leaves, strongly bordered exostome and high basal membrane preclude the genus from that family, and rather show its affinities with Hypnaceae. Journal of Bryology (2009) 31: 197–210
|
2022-08-30T01:49:48.076Z
|
94,322,924 |
{
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"DOI": "10.1021/JP9009756",
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|
Very small spherical nanoparticles (size in the range of 2−5 nm) of Y2Sn2O7 doped with both Ce3+ and Tb3+ were prepared by the urea hydrolysis of Y3+, Sn4+, Ce3+, and Tb3+ in ethylene glycol medium at 150 °C followed by heating at 700 °C. These nanoparticles exhibit very poor energy transfer between Ce3+ and Tb3+ ions and associated luminescence due to the combined effect of centrosymmetric D3d environment around the lanthanide ions and quenching of the lanthanide ion excited state due to the vibrations of surface hydroxyl groups present on the nanoparticles. However, the energy transfer and associated luminescence can be significantly improved after dispersing the nanoparticles in silica matrix. On the basis of the detailed steady-state and time-resolved luminescence studies, it has been established that a significant amount of Ce3+ and Tb3+ ions migrate from Y2Sn2O7 host to both the silica matrix and the interface region between silica and Y2Sn2O7 nanoparticles. Improved energy transfer from Ce3+ to Tb3...
|
2022-09-24T01:24:13.766Z
|
104,395,186 |
{
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"DOI": "10.15406/mojbb.2018.05.00121",
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},
"license": null,
"status": "CLOSED",
"url": null
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|
The number of new drug candidates with poor aqueous solubility and dissolution rate has grown steadily over the past two decades due to the use of high throughput and combinatorial screening tools during the drug discovery and selection phase.1 Improvement of oral bioavailability of poorly water-soluble drugs remains one of the most challenging aspects of drug development. Many approaches, such as salt formation, solubilization and particle size reduction have commonly been used to increase dissolution rate and thereby oral absorption and bioavailability of such drugs.2 However; all these techniques have potential limitations. All poorly soluble drugs are not suitable for improving their solubility by salt formation. Use of co-solvents or surfactants to improve dissolution rate pose problems and decreasing particle size increases solubility but there is poor wetting and flow.3–6 Solid dispersions can overcome these problems. Many carriers used in solid dispersions also cause problems due to their hygroscopic nature. Hence, continuous search for new carriers and new techniques is going on which will be useful for large scale manufacturing. Research for alternative carriers has been increasing to suit for the industrial applications as well as to reduce the production cost and toxic effects. Many polymers have limitations in enhancing solubility of poorly water soluble drugs due to their high viscosity. Use of polymers with low viscosity and high swelling capacity offers better alternative for these types of polymers. Use of natural polymer is more beneficial because of their low cost, biocompatibility, and biodegradability.7 Cost effective pharmaceutical excipients are always desirable. Pharmaceutical excipients developed from natural sources are economic. Present day consumers look for natural ingredients in food, drugs and cosmetics as they believe that anything natural will be safer and devoid of side effects.8,9 Natural excipients show lack of toxicity, easy availability and economic considerations in pharmaceutical industry as compared to their synthetic counterparts. Naturally, derived excipients have shown promising results in the modification of drug release from the formulations.10
|
2022-12-07T23:18:55.129Z
|
42,047,198 |
{
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"DOI": "10.20529/IJME.2012.006",
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"license": null,
"status": null,
"url": null
}
|
WHO-TDR and the Indian Council of Medical Research recommend site visits by institutional ethics committees (IECs) for continued oversight, to ensure the ethical conduct of research. Our IEC conducted seven site visits in 2008-2009 using a standardised format to monitor adherence to protocol and the informed consent process. The study identified issues related to informed consent (6/7), deviation from protocol (5/7), reporting of study progress to the IEC (3/7), recruiting additional participants without IEC approval (2/7), reporting of serious adverse events (1/7), investigator's lack of awareness of protocol and the informed consent document (2/7) and other findings. Investigators were informed about the findings and were asked to submit an explanation. The IEC issued warnings about not repeating such lapses in the future (5/7), restricted enrollment of new participants (2/7), recommended continued good clinical practice training to the study team (4/7), advised the recruitment of additional study coordinators (2/7), and requested the submission of adverse event reports (2/7) or sponsors' audit reports (2/7). Our study showed that the ethical conduct of studies can be ensured by conducting routine site monitoring.
|
2022-12-12T06:39:25.048Z
|
203,044,841 |
{
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"DOI": "10.26441/rc18.2-2019-a8",
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},
"license": "CCBYNC",
"status": "GOLD",
"url": "https://revistadecomunicacion.com/article/download/1291/1105"
}
|
A partir del análisis de discurso de las intervenciones de los conductores de noticiarios de TV abierta de Chile durante el terremoto de 8,8 Mw de 2010, se desarrolló una propuesta conceptual de perfiles y roles que estos pueden asumir durante la cobertura de un desastre. Esta se usó para identificar y describir la presencia de tres potenciales perfiles: informativo (presentación descriptiva del contenido), opinante (predominio del juicio de valor), y de diálogo con la audiencia (mensaje directo a los espectadores). Los datos muestran que el perfil predominante fue el informativo, que el opinante aparece con fuerza durante los primeros días de desastre y luego se debilita, y que el de diálogo con la audiencia comienza a tomar fuerza desde el tercer día. Estos resultados abren una línea de investigación sobre el rol de los medios en la promoción de la recuperación espontánea del trauma que experimenta la población.
|
2022-12-19T08:11:41.534Z
|
240,511,343 |
{
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"DOI": "10.1002/essoar.10508045.1",
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"url": null
}
|
About 60 percent of the hydrographic stations show negative bias for collected river 12 discharge. 13 Nearly 80 percent of the hydrographic stations show good skill with significant mean 14 abs...
|
2022-02-07T20:17:18.169Z
|
242,871,574 |
{
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"DOI": "10.7767/9783205213697",
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}
|
Our goal is always to offer you an assortment of cost-free ebooks too as aid resolve your troubles. We have got a considerable collection of totally free of expense Book for people from every single stroll of life. We have got tried our finest to gather a sizable library of preferred cost-free as well as paid files. This is really going to save you time and your money in something should think about. If you're seeking then search around for online. Without a doubt there are several these available and a lot of them have the freedom. However no doubt you receive what you spend on. An alternate way to get ideas would be to check another osterreichisches jahrbuch fur politik 2018. Need a magnificent e-book? osterreichisches jahrbuch fur politik 2018 by , the most effective one! Wan na get it? Locate this exceptional e-book by here currently. Download and install or review online is offered. Why we are the best website for downloading this osterreichisches jahrbuch fur politik 2018 Of course, you could select the book in various report kinds and media. Try to find ppt, txt, pdf, word, rar, zip, as well as kindle? Why not? Get them below, currently! GO TO THE TECHNICAL WRITING FOR AN EXPANDED TYPE OF THIS OSTERREICHISCHES JAHRBUCH FUR POLITIK 2018, ALONG WITH A CORRECTLY FORMATTED VERSION OF THE INSTANCE MANUAL PAGE ABOVE.
|
2022-05-13T02:21:16.818Z
|
33,383,265 |
{
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"ACL": null,
"ArXiv": null,
"DOI": "10.1139/O83-149",
"MAG": "2051263364",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Incubation of intact platelets with prostaglandins (PGE1 and PGI2) and phosphodiesterase inhibitors (1-methyl-3-isobutylxanthine, indomethacin, dipyridamol) lead to activation of cAMP phosphodiesterase. The activation was rapid (maximal within 30 s) and stable after removal of agents and homogenization of platelets. The activation remained after DEAE-Sepharose chromatography. The effect of the two types of agents on phosphodiesterase activity was more than additive and activation did not alter the nonlinear kinetic behavior of phosphodiesterase. The mechanism of the ex vivo stimulation is unknown at the present time, however, it does not seem to be due to cellular redistribution of the enzyme. The results suggest that activation of a cAMP-dependent protein kinase is an intermediate step. The ex vivo stimulation is regulated by a calcium-dependent process, since addition of Ca2+ ions and ionophore A23187 to Ca2+ depleted platelets abolished the ex vivo stimulation by PGE1 and MIX.
|
2022-06-28T10:55:01.874Z
|
78,600,275 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1158/1538-7445.AM2015-SY19-01",
"MAG": "2563325869",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Dynamic re-wiring of signaling networks is a prominent mechanism responsible for the development of resistance to many molecular-targeted anti-cancer agents. Here we show how this same dynamic re-wiring process can be used therapeutically to enhance the response of tumors to cytotoxic anti-cancer agents. Using cell lines and murine tumor models of triple-negative breast cancer, non-small cell lung cancer, and head and neck cancer, we show that chronic inhibition of EGFR and/or FGFR driver oncogenes dramatically enhances cell death in response to topoisomerase inhibitors and platinum DNA crosslinking drugs. In marked contrast, no such sensitization is observed when the growth factor receptor inhibitors are co-administered with the cytotoxic agents. The molecular mechanism responsible for this time-dependent growth factor inhibitor-induced tumor cell sensitization was explored using a systems biology-based model of DNA damage signaling in which protein kinase activities, substrate phosphorylation, and phosphoprotein-binding events for multiple signaling pathways were quantitatively measured at densely sampled points in time, and mathematically correlated with tumor cell responses including cell cycle arrest, cytokine production, autophagy, and apoptosis. This analysis revealed that sustained EGFR/FGFR suppression unmasks an apoptotic network involving Caspase-8 that is normally suppressed by oncogene addiction, resulting in an enhanced apoptotic response to equivalent amounts of DNA damage. This discovery demonstrates that the timing interval between administration of different drugs in combination chemotherapy can have profound effects on the tumor response through the dynamic re-wiring of cell signaling pathways in real time. Finally, we take advantage of this dynamic re-wiring process by developing tumor-targeted time-staggered release nanoparticles that deliver EGFR inhibitors at early times followed by the delayed release of doxorubicin. We show that these nanoparticles cause dramatic regression of murine NSCLC and TNBC tumor xenografts in vivo, substantiating the utility of therapeutic network re-wiring for anti-cancer therapy in the clinic. Citation Format: Michael J. Lee, Yogesh Dayma, Anne-Margriet Heijinks, Stephen W. Morton, Erik C. Dreaden, Paula T. Hammond, Michael B. Yaffe. Therapeutic network re-wiring of the DNA damage response can be used to enhance tumor killing by cytotoxic chemotherapy. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr SY19-01. doi:10.1158/1538-7445.AM2015-SY19-01
|
2022-02-11T04:41:31.637Z
|
145,112,736 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1177/1541204014551427",
"MAG": "2088220814",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The current study tested whether teacher-rated externalizing behavior and academic (reading) performance mediate the relationship between childhood onset conduct disorder and self-reported adolescent delinquency and officially recorded adult offending. All 411 boys from the Cambridge Study of Delinquent Development served as participants in this study. Mediation analysis revealed that the direct effect of childhood onset conduct disorder and the indirect effect of reading performance on mid-adolescent delinquency and early adult offending were nonsignificant, but that adolescent externalizing behavior had a significant indirect effect on both delinquency and adult offending.
|
2022-08-27T06:30:16.418Z
|
16,643,298 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3390/F7030057",
"MAG": "2292058419",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Variability in woody plant species, vegetation assemblages and anthropogenic activities derails the efforts to have common approaches for estimating biomass and carbon stocks in Africa. In order to suggest management options, it is important to understand the vegetation dynamics and the major drivers governing the observed conditions. This study uses data from 29 sentinel landscapes (4640 plots) across the southern Africa. We used T-Square distance method to sample trees. Allometric models were used to estimate aboveground tree biomass from which aboveground biomass carbon stock (AGBCS) was derived for each site. Results show average tree density of 502 trees·ha−1 with semi-arid areas having the highest (682 trees·ha−1) and arid regions the lowest (393 trees·ha−1). The overall AGBCS was 56.4 Mg·ha−1. However, significant site to site variability existed across the region. Over 60 fold differences were noted between the lowest AGBCS (2.2 Mg·ha−1) in the Musungwa plains of Zambia and the highest (138.1 Mg·ha−1) in the scrublands of Kenilworth in Zimbabwe. Semi-arid and humid sites had higher carbon stocks than sites in sub-humid and arid regions. Anthropogenic activities also influenced the observed carbon stocks. Repeated measurements would reveal future trends in tree cover and carbon stocks across different systems.
|
2022-10-14T01:23:35.585Z
|
254,217,385 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.17721/tppe.2022.44.4",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "http://tppe.econom.univ.kiev.ua/data/2022_44/zb44_04.pdf"
}
|
The article defines the essence and features of distance employment, analyzes the challenges and problems of personal management in the distant format of work, as well as the factors that determine the effectiveness of such work. The scientific novelty of the study is the systematization of features of distance employment and influencing factors on the effectiveness of personal management. An element of novelty also includes the analysis of the challenges of of personal management under the conditions of distance employment based on the author's sociological survey. A SWOT analysis of the transformational leadership theory as a method of effective work of personal management was conducted. The use of the "Technology-Organization-Environment" theory made it possible to single out main factors influencing the effectiveness of distance work of personal management: balanced state regulation; developed IT infrastructure; awareness of employees in the use of digital and communication technologies; organizational support of employees; workplace comfort; development of the necessary "soft skills" are positive attitude to work, concentration and emotional stability. The results of the author's survey on the experience of distance employment confirmed the generally positive assessment by employees of the distance work format. Many respondents noted increased productivity and a willingness to improve skills for work efficiency and effectiveness. At the same time, the survey also showed that distance employment has complications that can affect performance and labor relations. Communication, the system of management and leadership are undergoing a significant transformation. The lack of live communication has a significant impact on the cultural spirit and motivation of employees. Changing the work format requires employees to maintain high concentration during the working day and time management skills Based on the completed analysis, the methods of increasing the efficiency of management were singled out. The research hypothesis that the transformation of management methods in conditions of remote employment can increase the efficiency of employees' work has been confirmed.
|
2022-12-10T09:17:04.470Z
|
111,166,501 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/TELESC.2000.918447",
"MAG": "2111922980",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This paper describes the proposed improvement in the reliability of uninterruptible power supply systems for the powering of telecom equipment on the basis of redundant connection of an AC UPS and electric generator. The proposed improvement provides higher reliability of power supply system performance achieved by more efficient using of full resources of UPS and by special procedure of starting up of generator in operation. This feature is particular beneficial for the peculiarity of conditions of the mains (commercial source of electric power) in local utilities in Russia and the CIS. It concludes that the use of proposed procedure of operation in power systems is an effective way for a substantial improvement in reliability of total system and to avoid the mechanical wear of generator as well.
|
2022-12-17T06:25:26.737Z
|
74,017,277 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1136/SEXTRANS-2015-052126.174",
"MAG": "2284556082",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Background/introduction County Durham and Darlington NHS Foundation Trust (CDDFT) recently published local standards of care for patients disclosing sexual assault within the sexual health service. CDDFT is the sole provider of sexual health services throughout the county, offering fully integrated GUM, Family Planning and HIV clinics. Aim(s)/objectives This study aims describe the current management of sexual assault within CDDFT Sexual Health Services. Methods Patients who disclosed an alleged sexual assault from 01.01.2014–31.12.2014 were identified by local electronic codes and retrospective case note review was performed. Summary statistics were calculated using STATA v 11.0 and means /percentages presented as appropriate. Results Of 55 patients reporting alleged sexual assault, 44 case notes were available for review (80%). 39 patients were female (89%) and 5 were male (11%) with a similar mean age of 24.5 years. Police involvement was equally prevalent in patients reporting recent verses historical sexual assault (18/28 (64%) v 9/16 (56%) p = 0.52) and incident details were recorded in all cases where police referral was declined (17/17, 100%). 39/44 patients accepted STI screening, 7/44 patients were at risk of unwanted pregnancy and accepted emergency contraception; 12/44 patients were offered prophylactic antibiotics and 24/44 were offered Hep B vaccination; 6/44 patients commenced PEP and 6/8 under 18 year olds were referred to local safeguarding teams. Discussion/conclusion Patients reporting alleged sexual assault were seen infrequently but often had complex needs. Implementing new local policy with strengthen our ability to identify these patients and standardise our approach to management.
|
2022-12-20T04:39:36.836Z
|
81,239,441 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1200/JCO.2018.36.15_SUPPL.11567",
"MAG": "2892325722",
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},
"license": null,
"status": null,
"url": null
}
|
11567Background: Synovial, Clear cell, Angiosarcoma, adult Rhabdomyosarcoma and Epithelioid sarcoma is often referred to by the mnemonic SCARE as soft tissue sarcoma subtypes with higher risk of ly...
|
2022-08-11T14:18:36.448Z
|
34,714,855 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1542/peds.2008-1645",
"MAG": "1999768571",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
REFERENCES 1. Keidan I, Gravenstein D, Berkenstadt H, Ziv A, Shavit I, Sidi A. Supplemental oxygen compromises the use of pulse oximetry for detection of apnea and hypoventilation during sedation in simulated pediatric patients. Pediatrics. 2008;122(2):293–298 2. Cook TM, Wolf AR, Henderson AJ. Changes in blood-gas tensions during apnoeic oxygenation in paediatric patients. Br J Anaesth. 1998;81(3):338–342 3. Patel R, Lenczyk M, Hannallah RS, McGill WA. Age and the onset of desaturation in apnoeic children. Can J Anaesth. 1994; 41(9):771–774
|
2022-08-28T10:25:25.136Z
|
7,136,555 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/jan.12719",
"MAG": "1922768758",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
AIM
To conduct an integrative review of primary research examining patient care roles introduced into emergency department waiting rooms.
BACKGROUND
Internationally, emergency departments are under pressure to meet increasing patient demand with limited resources. Several initiatives have been developed that incorporate a healthcare role in waiting rooms, to assess and initiate early interventions to decrease waiting times, detect patient deterioration and improve communication. The literature reporting these roles has not been systematically evaluated.
DESIGN
Integrative review.
DATA SOURCES
Published English-language peer reviewed articles in CINAHL, Scopus, Medline and Web of Knowledge between 2003-2014.
REVIEW METHODS
Identified literature was evaluated using an integrative review framework, incorporating methodological critique and narrative synthesis of findings.
RESULTS
Six papers were included, with three waiting room roles identified internationally - clinical initiative nurse, Physician-Nurse Supplementary Assessment Team and clinical assistants. All roles varied in terms of definitions, scope, responsibilities and skill sets of individuals in the position. There was limited evidence that the roles decreased waiting times or improved patient care, especially during busy periods. Of note, staff members performing these roles require high-level therapeutic relationship and effective interpersonal skills with patients, family and staff. The role requires support from other staff, particularly during periods of high workload, for optimal functioning and effective patient care.
CONCLUSION
Generalisations and practice recommendations are limited due to the lack of available literature. Further research is required to evaluate the impact emergency department waiting room roles have on patient outcomes and staff perspectives.
|
2022-09-15T08:05:11.585Z
|
46,977,408 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/27.736042",
"MAG": "2109353899",
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
Successful introduction of pulsed corona for industrial purposes very much depends on the reliability of high-voltage and pulsed power technology and on the efficiency of energy transfer. In addition, it is of the utmost importance that adequate electromagnetic compatibility (EMC) is achieved between the high-voltage pulse source and the surrounding equipment. Pulsed corona is generated in a pilot unit that produces narrow 50 MW pulses at 1000 pps (net average corona power 1.5 kW). The pilot unit can run continuously for use in industrial applications such as cleaning of gases (100 m/sup 3//h) containing NO or volatile organic compounds (VOCs) or fluids (e.g., waste water). Simultaneous removal of NO and ethylene to obtain clean CO/sub 2/ from the exhaust of a combustion engine was tested at an industrial site. Various chemical processes, such as removal of toluene or styrene from an airflow are tested in the laboratory. We developed a model to analyze the conversion of these pollutants. To examine the discharges in the reactor we use current, voltage, and E-field sensors as well as a fast charge-coupled device (CCD) camera. Detailed energy input measurements are compared with CCD movies to investigate the efficiency of different streamer phases. EMC techniques incorporated in the pilot unit are based on the successful concept of constructing a low transfer impedance between common mode currents induced by pulsed power and differential mode voltages in signal lines and external main lines.
|
2022-12-18T23:48:09.071Z
|
14,915,470 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/ICCITECHN.2014.6997331",
"MAG": "1973253071",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This paper represents design, analysis & investigation of an radiator for UHF RFID applications. This antenna covered the frequency spectrum 2392.86-2457.14MHz with bandwidth 14.28MHz which is sufficient for RFID tag applications. We have designed as well as simulated this antenna using Numerical Electromagnetic Code (NEC) antenna modeling software package which is based on the method of moments solution and after simulation we have got SWR exactly 1.097 having reflection coefficient -26.68 without filtering and after passing through a low-pass L-network the SWR value is sharply 1.00054 with reflection coefficient -71.386 at 2.45 GHz band. The total antenna gain is excellent and it is approximately 22.3 dBi. We have achieved the decent impedance that is 48.36-j4.95 ohm before filtering and 49.99-j0.029 ohm after filtering. Afterward we have fabricated this designed antenna on a low-cost printed circuit board with ground plane including dielectric constant 4.4 & thickness of the metal 1.58mm. The efficiency of the proposed antenna is 99.96%. The measurement shows that the SWR value is 1.05404 at 0 dB attenuation.
|
2022-12-27T21:09:09.002Z
|
141,648,443 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5204/QUTLR.V1I2.71",
"MAG": "649876511",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This paper analyses a number of areas in which issues of gender and power between men and women arise in the context of relationship breakdown, most specifically in the Family Court. These areas include power imbalances in the family law process, family violence and denial of access to legal representation, as well as broader socio-economic issues such as differential earning capacity and its consequences.The Family Court is both a major provider of primary dispute resolution services and the forum in which many family law disputes are determined. The paper discusses several ways in which the Court recognises the vulnerability of its clients and seeks to address any imbalances between them.
|
2022-09-08T02:02:32.564Z
|
90,063,906 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1556/034.60.2018.1-2.4",
"MAG": "2794133359",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "http://real.mtak.hu/79021/1/034.60.2018.1-2.4.pdf"
}
|
Species delimitation is essential since species is regarded as the basic unit of analysis in nearly all biological disciplines, such as ecology, biogeography, conservation biology, and macroevolution. The genus Geranium (Geraniaceae) comprises about 350 species distributed throughout most parts of the world. The subg. Robertium comprises 30 species which are arranged in 8 sections. This subgenus is represented in Iran by 10 species. These species are grouped into 5 sections. In spite vast distribution of many Geranium species that grow in Iran, there are not any available report on their genetic diversity, mode of divergence and patterns of dispersal. Therefore molecular (ISSR markers) and morphological studies of 147 accessions from 10 species of Geranium (subg. Robertium), that were collected from different habitats in Iran were performed. The aims of the present study are: 1) to find the diagnostic value of ISSR markers in delimitation of Geranium species, 2) to find the genetic structure of these taxa in Iran, and 3) to investigate the species inter-relationship. The present study revealed that combination of morphological and ISSR data can delimit the species. AMOVA and STRUCTURE analysis revealed that the species of subg. Robertium are genetically differentiated but have some degree of shared common alleles.
|
2022-09-12T03:29:28.878Z
|
13,685,038 |
{
"externalids": {
"ACL": null,
"ArXiv": "1804.10177",
"DOI": "10.1364/ao.57.003281",
"MAG": "2949996838",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "http://arxiv.org/pdf/1804.10177"
}
|
We report on an optical imaging design based on common-path off-axis digital holography, using a multiplexed volume Bragg grating. In the reported method, a reference optical wave is made by deflection and spatial filtering through a volume Bragg grating. This design has several advantages, including simplicity, stability, and robustness against misalignment.
|
2022-09-11T02:42:40.962Z
|
252,841,598 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/SeFeT55524.2022.9909339",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
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|
This paper presents a study focused on the solar-based switched reluctance motor (SRM) irrigation pump drive with a grid-support through a single-phase Vienna rectifier. Vienna rectifier is a unidirectional active power flow-controlled AC-DC converter with improved power quality. In this work, a hysteresis current controller (HCC) based Vienna control is used to draw grid current with minimum harmonics while maintaining the unity power factor (UPF) condition. Besides this, Vienna rectifier offers a three-level balanced DC voltage at the output with minimum ripple content, suitable for mid-point converter feeding the balanced supply to all the phases of SRM. The employed Vienna control ensures the grid-side power quality parameters follows the IEEE-519 recommendations throughout the operation and facilitates rated water discharge irrespective to the environmental conditions. The obtained results suggest that Vienna rectifier-based grid-interference provides an effective and reliable solution for solar fed irrigation pumps in compliance with the power quality norms.
|
2022-10-13T17:45:13.535Z
|
30,005,087 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1128/aem.53.3.505-508.1987",
"MAG": "1572105842",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "https://europepmc.org/articles/pmc203696?pdf=render"
}
|
The lytic action of glycerol and sucrose esters of fatty acids with different carbon chain lengths on the exponentially growing cells of Bacillus subtilis 168 was investigated. Of each series of esters, glycerol dodecanoate and sucrose hexadecanoate were the most active. Lysis at 1 h after the addition of 0.1 mM glycerol dodecanoate or 20 μg of sucrose hexadecanoate per ml was 81 or 79%, respectively, as evaluated by the reduction in optical density. During this treatment a great loss of viability occurred that preceded lysis. The results that were obtained suggest that autolysis is induced by these esters. The esters caused morphological changes in the cells, but a seeming adaptation of the cells to esters was seen.
|
2022-10-07T00:55:55.511Z
|
17,748,251 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/WI.2016.0033",
"MAG": "2571900796",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Football (aka Soccer) is the most popular sport in the world. The popularity of the sport leads to several stories (some perhaps anecdotal) about supporters behaviors and to the emergence of rivalries such as the famous Barcelona-Real Madrid (in Spain). Little however has been done to characterize/profile online users' behaviors as football supporters and use them as an aggregate measure to club characterization. Today, the availability of data enable us to understand at a much greater scale if rivalries exist and if there are signatures that can be used to characterize supporting behavior. In this paper we use techniques from Data Science to characterize football supporters according to their activity on Twitter and to characterize clubs according to the behavior of their supporters. We show that it is possible to: (i) rank football clubs by their popularity and fans' dislike, (ii) identify the rivalries that exist between clubs and their supporters, and (iii) find specific signatures that repeat themselves across different clubs and in different countries. The results are evaluated on a large dataset of tweets relevant to major football leagues in Brazil and in the United Kingdom.
|
2022-10-21T16:04:39.676Z
|
22,326,615 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1366/000370210791114301",
"MAG": "1988630573",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Mid-infrared (mid-IR) analysis of solid biomaterials by the familiar KBr disc technique is all too often frustrated by water interference in the very important protein (amide) and carbohydrate (hydroxyl) regions of their spectra. A method was therefore devised that overcomes the difficulty and corrects IR spectra of solid biomaterials in KBr discs by mathematically eliminating the interference that arises from water molecules absorbed and bound in the KBr crystal lattice. The derivation of a linear system of chemometric equations that solves the water interference problem in a rigorous objective way is presented. Infrared spectra that result after correction by the method can be used reliably for quantitative analysis as well as structure identification. A major advantage is realized in quantitative analysis as the technique permits cryogenic pulverization of the biomaterial in KBr to prevent change in chemical structure and minimize the particle size to closely approach the solid solution condition required by the Beer–Lambert law. Extensive pulverization, which produces large water absorption bands that overlap and obscure the amide and hydroxyl regions of interest, is no longer problematic. The method is illustrated by removing strong water interference to extract the spectra of corn starch and gluten in pressed KBr discs. Results of the new method are compared with attenuated total reflection (ATR) spectra of gluten corrected using the conventional advanced ATR correction algorithm.
|
2022-10-29T09:01:53.507Z
|
172,107,423 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1515/agph-1971-0303",
"MAG": "2566119769",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
I. Mit seinen Gedanken über die Relation „Ganzes und Teil" knüpft Leibniz weder an Aristoteles an, noch führt er mit ihnen zu Kant hin — um nur die wichtigsten begriffsgeschichtlichen Bezugspunkte zu nennen. Sich diese Bezüge zu vergegenwärtigen, ist trotzdem für eine Beurteilung der leibnizischen Position notwendig, was wiederum, wie sich zeigen wird, zwei Unterscheidungen erforderlich oder doch wünschenswert macht, die sich bei keinem der drei Denker finden. Wir wollen zunächst komplektierende und strukturelle Ganze unterscheiden: jene sind aufgehäuft wie ein Haufen von vielleicht auch zugeschnittenen Brettern, diese gegliedert wie ein aus Brettern gefügter Kasten mit einem Boden, mit Seitenwänden usf., um ein aristotelisches Beispiel zu nehmen. Dort sind abweichende Eigenschaften unter den Teilen irrelevant oder nicht vorhanden, hier bedingen gerade untereinander verschiedene Teile besondere Bestimmungen für das Ganze. Ferner empfiehlt es sich, da das Kategorienproblem in unsere Thematik hereinspielt, generelle und regionale Kategorien einander entgegenzusetzen: jene gelten für alles Seiende wie die vier ersten aristotelischen Kategorien der Substanz, der Qualität, der Quantität und der Relation, diese nur für bestimmte Bezirke des Seienden, z. B. bei Aristoteles das Wo, das Wann und das Wirken (zunächst) in der Natur, das Wirken und Leiden bei Lebewesen, das Denken bei beseelten Wesen nach Descartes. Bei Aristoteles erscheint die Relation zwischen Ganzem und Teilen nicht unter den Kategorien. Das Ganze (öAov) wird als dasjenige definiert, woran nichts fehlt wie beim ganzen Menschen oder ganzen Kasten; woran etwas fehlt, das ist kein Ganzes (ttccv). Die Ausdrücke oAov und t t5v sind hier also synonym und bezeichnen
|
2022-12-19T08:59:23.693Z
|
24,249,385 |
{
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"DOI": "10.1002/jbm.a.33033",
"MAG": "2112372122",
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"status": null,
"url": null
}
|
The goal of this study was to design a nontoxic scaffold with both composition and microstructure suitable for bone engineering using collagen (Coll), hydroxyapatite (HA), and poly(lactide-co-ε-caprolactone) (PLCL). Mineralized type I Coll was produced by direct nucleation of HA particles inside self-assembled Coll fibers to obtain a Coll/HA complex, which was then added to dissolved PLCL (70:30) in 1,4-dioxane. A 3D porous Coll/HA/PLCL scaffold was subsequently produced through freeze-drying/lyophilization and salt-leaching procedures. The resulting Coll/HA/PLCL scaffold displayed a high uniform porosity and highly interconnected pores. X-ray photoelectron spectrometer and Fourier transform infrared analyses revealed the presence of both collagen and HA particles on the surface of the Coll/HA/PLCL scaffold. Proliferation assay, microscopic observations, and gene analysis with quantitative RT-PCR showed that osteoblast cells were able to attach, proliferate, and maintain an osteoblastlike phenotype when cultured on the Coll/HA/PLCL scaffold. In summary, we produced a nontoxic scaffold that contains natural polymers (Coll and HA) and synthetic polymer (PLCL). Through its chemical composition and porous morphology, this scaffold may be useful for osteoblast growth, differentiation, and bone tissue formation.
|
2022-12-18T10:43:36.624Z
|
30,535,665 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1042/BST20150215",
"MAG": "2255991663",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Eukaryotic cells have ubiquitously utilized the myo-inositol backbone to generate a diverse array of signalling molecules. This is achieved by arranging phosphate groups around the six-carbon inositol ring. There is virtually no biological process that does not take advantage of the uniquely variable architecture of phosphorylated inositol. In inositol biology, phosphates are able to form three distinct covalent bonds: phosphoester, phosphodiester and phosphoanhydride bonds, with each providing different properties. The phosphoester bond links phosphate groups to the inositol ring, the variable arrangement of which forms the basis of the signalling capacity of the inositol phosphates. Phosphate groups can also form the structural bridge between myo-inositol and diacylglycerol through the phosphodiester bond. The resulting lipid-bound inositol phosphates, or phosphoinositides, further expand the signalling potential of this family of molecules. Finally, inositol is also notable for its ability to host more phosphates than it has carbons. These unusual organic molecules are commonly referred to as the inositol pyrophosphates (PP-IPs), due to the presence of high-energy phosphoanhydride bonds (pyro- or diphospho-). PP-IPs themselves constitute a varied family of molecules with one or more pyrophosphate moiety/ies located around the inositol. Considering the relationship between phosphate and inositol, it is no surprise that members of the inositol phosphate family also regulate cellular phosphate homoeostasis. Notably, the PP-IPs play a fundamental role in controlling the metabolism of the ancient polymeric form of phosphate, inorganic polyphosphate (polyP). Here we explore the intimate links between phosphate, inositol phosphates and polyP, speculating on the evolution of these relationships.
|
2022-12-28T20:31:06.063Z
|
219,067,041 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.32702/2307-2105-2020.4.201",
"MAG": "3022035435",
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "http://www.economy.nayka.com.ua/pdf/4_2020/203.pdf"
}
|
У статті здійснено порівняльну оцінку впливу окремих інструментів державного регулювання на економічний розвиток країни. Здійснено порівняня впливу окремих інструментів державного регулювання, зокрема фіскального регулювання, на економічний розвиток країни. Розглянуто та охарактеризовано основні сучасні концепції побудови фіскальної політики як складової системи фіскального регулювання. Здійснено ретроспективний аналіз розвитку податкової системи в Україні. Проаналізовано динаміку та структуру податкових надходжень до Державного бюджету України за прямими та непрямими податками. Оцінено взаємозв’язок податкових надходжень та валового внутрішнього продукту. Визначено принципи та сучасні напрями реформування податкової системи України, як складової системи фіскального регулювання. Обґрунтовано, що в результаті зіткнення інтересів у суспільстві, повинен скластися рівноважний податковий тягар – оптимальний рівень податкового тиску, в основі якого лежать сукупні державні витрати, пов'язані з відтворенням державою своїх функцій з урахуванням співвідношення попиту на податки (покриття потреб держави) і пропозиції дохідних джерел.
|
2022-02-08T01:38:58.142Z
|
79,504,262 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1136/BMJ.J1759",
"MAG": "2789258657",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
With the proportion of women in medicine reaching 50%, Abi Rimmer looks at whether there is still a need to campaign for gender equality in the profession
|
2022-02-11T03:52:06.426Z
|
53,112,703 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1200/EDBK_159060",
"MAG": "2413905242",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Editor's Note: The following article is based on the 2016 ASCO Annual Meeting Education Session "Less Is More: A Multidisciplinary Conversation on Treatment Options." The authors review the indications for reducing the treatment burden for women with breast cancer by capitalizing on the emerging opportunity to identify and recognize more indolent forms of the disease using advanced tools, therapies, and screening methods.
|
2022-07-09T04:11:38.406Z
|
24,926,056 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1093/JMEDENT/26.5.474",
"MAG": "2155520825",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The egg of Aedes triseriatus (Say) is described with the aid of scanning electron micrographs. The egg is dull black, very broadly cigar shaped, and slightly tapered posteriorly. The length is about 681 microns and the width about 202 microns. On the ventral surface, the irregularly pentagonal or hexagonal outer chorionic cells are about as long as wide and are bounded by the greatly elevated walls of the chorionic reticulum. Each cell has usually one (occasionally two or three) large tubercles set in the cell corners, abutted against the reticulum wall. On the dorsal surface, the chorionic cells are different in structure, each filled by a large, smooth domed tubercle. The micropylar collar is continuous (without gaps), and the micropylar disk is especially clearly defined and has a raised outer margin.
|
2022-11-29T17:02:54.390Z
|
244,505,426 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1161/res.129.suppl_1.p314",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Heart failure is a common and morbid disease frequently caused by dilated cardiomyopathy (DCM). Fibrotic remodeling is a key feature of DCM. Stress signaling pathways trigger transdifferentiation of quiescent cardiac fibroblasts into myofibroblasts (MF). Bromodomain and extra-terminal (BET) epigenetic reader proteins are stress-responsive distal signaling integrators that drive fibrosis. Here, we explored the role of BETs on distinct inflammatory pathways in ex vivo cultured cardiac fibroblasts. The Langendorff hanging heart procedure was used to isolate and culture primary non-myocytes from wild type hearts, which are almost exclusively fibroblasts. Cells were stimulated with TGFβ2 to trigger MF transdifferentiation. Prior to TGFβ2 treatment, fibroblasts were treated with 1 of the following: vehicle, the BET inhibitor JQ1, or siRNA targeting either
Smad3
or
Rela
. MF-specific gene expression was assessed by Q-PCR. α-smooth muscle actin (αSMA) levels were assessed by immunocytochemistry (ICC) and immunoblotting. NFκB transcriptional activity was evaluated using a dual luciferase reporter assay. TGFβ2 activated MF-specific gene expression (
Acta2
, 9.0-fold;
Col3a1
, 3.6-fold;
Ctgf,
10.1-fold;
Postn
, 12.8-fold; p<0.05 for all vs. vehicle), and increased αSMA levels (1.5-fold by ICC and immunoblotting; p<0.05 vs. vehicle) in cultured primary cardiac fibroblasts. This was ablated by JQ1 and
Smad3
siRNA. By contrast,
Rela
siRNA alone induced MF-specific gene expression (
Acta2
, 6.9-fold;
Col3a1
, 7.0-fold;
Ctgf,
3.7-fold;
Postn
, 11.2-fold; p<0.05 for all vs. vehicle), and increased αSMA staining by ICC (3.4-fold; p<0.05) but not protein (1.3-fold; p=NS). TGFβ2 further potentiated MF-specific gene expression (
Acta2
, 17.1-fold;
Col3a1
, 7.1-fold;
Ctgf,
13.2-fold;
Postn
, 42.5-fold; p<0.05 for all vs. vehicle) and αSMA protein (1.7-fold; p<0.05) in fibroblasts treated with
Rela
siRNA. NFκB transcriptional activity was reduced by TGFβ2 (-2.9-fold; p<0.05) and with JQ1 pre-treatment (-2.7-fold; p<0.05). These data define a critical role for BETs in TGFβ2-mediated gene transcription in cardiac fibroblasts. Surprisingly, NFκB does not appear to be a key activator of TGFβ2-stimulated fibroblast transdifferentiation.
|
2022-12-11T10:31:12.815Z
|
153,011,922 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/joie.12033",
"MAG": "3023172574",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "https://dipot.ulb.ac.be/dspace/bitstream/2013/54078/1/RePEc_eca_wpaper_2008_010.pdf"
}
|
In this paper we abandon the usual assumption that patents bring known benefits to the industry or that their benefits are known to all parties. When royalty payments are increasing in one's patent portfolio, private information about the quality of patents leads to a variety of distortions, in particular the incentives of firms to "pad" by contributing weak patents. Three main results that emerge from the analysis are that: (i) the threat of court disputes reduces incentives to pad but at the cost of lower production of strong patents; (ii) mitigating this undesirable side-effect calls for a simultaneous increase in the cost of padding, that is, a better filtering of patent applications; (iii) upstream firms have more incentives to pad than vertically-integrated firms which internalize the fact that patent proliferation raises the share of profits going to the upstream segment of the industry but at the expense of its downstream segment. This seems consistent with recent evidence concerning padding.
|
2022-12-17T01:32:59.788Z
|
252,317,726 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3390/ijerph191811592",
"MAG": null,
"PubMedCentral": "9517091"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.mdpi.com/1660-4601/19/18/11592/pdf?version=1663743222"
}
|
Background: Sufficient communicative health literacy (COM-HL) is important for patients actively participating in dialogue with physicians, expressing their needs and desires for treatment, and asking clarifying questions. There is a lack of instruments combining communication and HL proficiency. Hence, the aim was to establish an instrument with sufficient psychometric properties for measuring COM-HL. Methods: The HLS19-COM-P instrument was developed based on a conceptual framework integrating HL with central communicative tasks. Data were collected using different data collection modes in nine countries from December 2019 to January 2021 (n = 18,674). Psychometric properties were assessed using Rasch analysis and confirmatory factor analysis. Cronbach’s alpha and Person separation index were considered for reliability. Results: The 11-item version (HLS19-COM-P-Q11) and its short version of six items (HLS19-COM-P-Q6) fit sufficiently the unidimensional partial credit Rasch model, obtained acceptable goodness-of-fit indices and high reliability. Two items tend to under-discriminate. Few items displayed differential item functioning (DIF) across person factors, and there was no consistent pattern in DIF across countries. All items had ordered response categories. Conclusions: The HLS19-COM-P instrument was well accepted in nine countries, in different data collection modes, and could be used to measure COM-HL.
|
2022-12-30T00:37:28.368Z
|
2,944,055 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3109/10428199609051609",
"MAG": "2026742716",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In this review, we discuss the possible relationship between the clinical characteristics and the integration patterns of human T-cell lymphotropic virus type I (HTLV-I) proviral DNA in patients with adult T-cell leukemia/ lymphoma (ATL). Some ATL patients show unusual integration patterns such as multiple or defective HTLV-I and have clinical characteristics unlike those of most ATL patients who have the characteristic integration pattern of one complete provirus. Multiple HTLV-I integrations can be detected as two or more bands using the standard Southern blotting method when the tumor cellular DNA is digested with an endonuclease that does not cleave within the provirus. This includes cases of one tumor cell clone carrying two or more copies of the provirus, or alternatively two or more cell clones, each carrying one copy of the provirus. The former group of patients always manifest severe dyspnea and hypoxemia with unusual organ infiltrations including the retina and muscle and an extremely aggressive clinical course. On the other hand, the latter group of patients have an indolent course with skin lesions or small T lymphocytes with cleaved or lobulated nuclei. A solitary defective HTLV-I in some ATL patients can be detected as one smaller band after digestion of cellular DNA with an endonuclease that does not cleave within the provirus. These patients generally have a favourable clinical course with small cleaved or bilobulated T lymphocytes without lymphadenopathy or skin lesions. These findings suggest that there are clinical implications for the integration patterns of HTLV-I and this may be one of the explanations for the heterogeneous behaviour of the disease. Such studies may provide information on the relationship between virus integration and the clinical manifestations and also improve our understanding of the pathogenesis of ATL.
|
2022-10-13T06:13:02.771Z
|
9,617,289 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4103/ipj.ipj_80_14",
"MAG": "2625025439",
"PubMedCentral": "5479098"
},
"license": "CCBYNCSA",
"status": "GOLD",
"url": "https://doi.org/10.4103/ipj.ipj_80_14"
}
|
Zolpidem, an imidazoline nonbenzodiazepine sedative drug, is used widely. Initial reports showed minimal abuse potential. However, multiple reports have appeared of dose escalation and abuse. Subjective effects of high-dose zolpidem are not known. In light of accumulating evidence of abuse potential, we hereby report a case of high-dose dependence and a review of relevant literature. A 33-year-old male presented with 5 years of daily use of 600–1700 mg of zolpidem tartrate. He reported subjective effects of euphoria, intense craving, and inability to stop use. Loss of receptor specificity, pharmacokinetic factors, and different receptor distributions can explain paradoxical stimulatory effects of high-dose zolpidem. Further studies are required to characterize subjective effects of high-dose zolpidem.
|
2022-11-08T07:18:17.278Z
|
253,267,553 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1136/bmjopen-2022-062853",
"MAG": null,
"PubMedCentral": "9639084"
},
"license": "CCBYNC",
"status": "GOLD",
"url": "https://bmjopen.bmj.com/content/bmjopen/12/11/e062853.full.pdf"
}
|
Introduction Adverse drug events (ADEs) among hospitalised older adults are common yet often preventable. Efforts to recognise ADEs using pharmacist review and electronic health record adaptations have had mixed results. Our health system developed and implemented a geriatric prescribing context designed to offer age-friendly dose and frequency defaults for hospitalised patients 75 years and older. The impact of this context on ADEs remains unknown. To measure its impact, our team created a list of ADE-related International Classification of Diseases (ICD) codes specific to 10 commonly used medications at our institution. This protocol paper presents the process of designing a screening tool for ADEs, validating the tool with manual chart reviews and measuring the impact of the context on ADEs. Methods and analysis This retrospective cross-sectional study will assess our list of ICD-10 codes against manual chart review to determine its accuracy. An electronic health record report for patients aged 75 years and older admitted to the hospital for a minimum of two nights was generated to identify 100 test positives and 100 test negatives. Test positives need at least one code from each level of our ICD-10 code list. The first level of codes identifies any possible ADEs while the second level is more symptom based. Test negatives must not have any code from the list. Two physicians blinded to test status will complete a structured chart review to determine if a patient had an ADE during their hospitalisation. Acceptable inter-rater reliability will need to be met before proceeding with independent chart review. Positive predictive value and negative predictive value will be calculated once all the chart reviews are completed. Ethics and dissemination The Oregon Health & Science University Institutional Review Board approved this study (#21385). The results of the study will be disseminated in peer-reviewed journals and conference presentations.
|
2022-12-10T01:35:37.754Z
|
40,039,656 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1097/00004583-199611000-00023",
"MAG": "2052020946",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
OBJECTIVE
To examine the adjustment of nondisabled siblings of handicapped children.
METHOD
In a 3-year longitudinal study, 46 siblings of children with pervasive developmental disorder (PDD), 45 siblings of children with Down syndrome, and 46 siblings of developmentally normal children (serving as controls) were examined at time 1 using the sibling, primary caretaker, and teacher as informants. Both direct and indirect variables related to sibling adjustment were considered.
RESULTS
Significantly more difficulties were found in the siblings of children with PDD compared with the other two groups. Different correlates of adjustment were present in the siblings of the disabled compared with nondisabled children, and mediating factors differed in parent and teacher reports of internalizing difficulties in siblings of children with PDD. Marital satisfaction, lack of parental depression, a cohesive family, and a warm, nonconflictual sibling relationship were protective for normal control and Down syndrome siblings but not for PDD siblings.
CONCLUSION
Findings underline the risks for the siblings of children with PDD and suggest the importance of a transactional mechanism rather than identification of single risk or protective factors in predicting sibling adjustment. Subsequent data analysis in this longitudinal study will assist in defining these mechanisms and allow for improved intervention strategies.
|
2022-12-20T02:41:42.059Z
|
44,588,794 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/cdc.1980.271868",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
New algorithms for direct adaptive control of non-minimum phase systems are presented. The algorithms are based on identification of models with special structure and pole-zero placement design. The models are such that the residuals are bilinear in the parameters.
|
2022-12-19T03:23:36.600Z
|
123,251,190 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1137/0603042",
"MAG": "2110645612",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "http://www.math.uiuc.edu/~west/pubs/nodup.pdf"
}
|
n people have distinct bits of information, which they communicate via telephone calls in which they transmit everything they know. We require that no one ever hear the same piece of information twice. In the case 4 divides $n,\,n\geqq 8$, we provide a construction that transmits all information using only $9n/4 - 6$ calls. Previous constructions used $\frac{1}{2}n \log n$ calls.
|
2022-12-21T09:13:47.838Z
|
12,790,969 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3109/07853890109002086",
"MAG": "2168973485",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The 15D is a generic, comprehensive, 15-dimensional, standardized, self-administered measure of health-related quality of life (HRQoL) that can be used both as a profile and single index score measure. This paper examines the acceptability, reliability, validity, discriminatory power and responsiveness to change of its health state descriptive system and valuation system and presents some examples of applications. As a profile measure on roughly comparable dimensions the 150 performs equally well as the Nottingham Health Profile (NHP) and SF-20, in some respects even better, and clearly better than EQ-5D. The remaining nine to ten dimensions of the 15D provide a large reserve in terms of discriminatory power and responsiveness to change. The valuation system is based on an application of the multiattribute utility theory. The single index score (15D score) on a 0–1 scale, representing the overall HRQoL, is calculated from the health state descriptive system by using a set of population-based preference or utility weights. The 15D scores are shown to be highly reliable, sensitive and responsive to change, generalisable at least in Western-type societies, and particularly valid for deriving quality-adjusted life years (QALYs) gained for resource allocation purposes. The instrument is recommended by the Washington Panel and is available in several languages for clinical economic evaluation and population studies.
|
2022-12-31T19:57:28.854Z
|
133,389,711 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1088/978-1-6817-4159-8CH7",
"MAG": "2501243905",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This book presents research into the physical rules that can underlie the behaviour of biota, as well as the geochemistry of soil development. It addresses both nutrient and water transport limitations of processes from chemical weathering to vascular plant growth. It attempts to bring order to the question of the extent to which soils can facilitate plant growth, and what limitations on plant sizes, metabolism, occurrence and correlations can be formulated thereby.
|
2022-02-09T12:39:32.864Z
|
79,569,292 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.12968/BJOM.1995.3.2.69",
"MAG": "2781807551",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A retrospective study of 103 opiate-dependent women in Liverpool compared their outcomes of pregnancy with those of non-drug-misusing controls matched by age, parity and postal code. The study group were all on a methadone programme and received regular antenatal care.
|
2022-09-12T12:14:12.630Z
|
112,528,657 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.12989/WAS.2016.22.1.107",
"MAG": "2346831746",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The need for a more affordable, reliable, clean and secure energy has led to explorations in non-traditional sources, particularly renewable energies. Wind is one of the cleanest energy sources that plays a significant role in augmenting sustainability. Wind turbines, as energy convertors, are usually tall and slender structures, and depending on their location (inland or offshore), they can be subject to high wind and/or strong wave loadings. These loads can cause severe vibrations with detrimental effects on energy production, structural lifecycle and initial cost. A dissipativity analysis study was carried out to know whether wind turbine towers require damping enhancement or rigidity modifications for vibration suppression. The results suggest that wind turbines are lightly damped structures and damping enhancement is a potential solution for vibration lessening. Accordingly, the paper investigates different damping enhancement techniques for vibration mitigation. The efficacy of tuned mass damper (TMD), tuned liquid column damper (TLCD), tuned sloshing damper (TSD), and viscous damper (VD) to reduce vibrations is investigated. A comparison among these devices, in terms of robustness and effectiveness, is conducted. The VD can reduce both displacement and acceleration responses of the tower, better than other types of dampers, for the same control effort, followed by TMD, TSD, and finally TLCD. Nevertheless, the use of VDs raises concerns about where they should be located in the structure, and their application may require additional design considerations.
|
2022-10-20T16:49:38.284Z
|
251,082,152 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3390/s22155482",
"MAG": null,
"PubMedCentral": "9332296"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.mdpi.com/1424-8220/22/15/5482/pdf?version=1658497587"
}
|
Falls pose a great danger to social development, especially to the elderly population. When a fall occurs, the body’s center of gravity moves from a high position to a low position, and the magnitude of change varies among body parts. Most existing fall recognition methods based on deep learning have not yet considered the differences between the movement and the change in amplitude of each body part. Besides, some problems exist such as complicated design, slow detection speed, and lack of timeliness. To alleviate these problems, a lightweight subgraph-based deep learning method utilizing skeleton information for fall recognition is proposed in this paper. The skeleton information of the human body is extracted by OpenPose, and an end-to-end lightweight subgraph-based network is designed. Sub-graph division and sub-graph attention modules are introduced to add a larger perceptual field while maintaining its lightweight characteristics. A multi-scale temporal convolution module is also designed to extract and fuse multi-scale temporal features, which enriches the feature representation. The proposed method is evaluated on a partial fall dataset collected in NTU and on two public datasets, and outperforms existing methods. It indicates that the proposed method is accurate and lightweight, which means it is suitable for real-time detection and rapid response to falls.
|
2022-10-30T06:17:41.035Z
|
193,814,133 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.18272/POSTS.V2I1.817",
"MAG": "2600317538",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
uno: rumor del inicio era tu voz, ?tu voz?, no, tu pisada. francisco granizo desde los anos noventa, trabajo con video; me inicie con el formato betamax cuando su uso iba entrando en caducidad, en extincion, he transitado por periodos analogicos y digitales de distinta intensidad y algunas pausas no deseadas, las practicas documentales home y la estetica amateur fueron mi punto de partida y, con el tiempo, el lugar desde el cual me enuncio artisticamente, el impulso es usar el video como una libreta de apuntes que se desborda del soporte camara: instantaneas, sketches, proyecciones fallidas, recortes, objetos encontrados, manuales de uso… un archivo personal. las primeras experiencias de registro me mostraron que la atadura "video = television" tenia mucho peso localmente, los usos experimentales del video no estaban generalizados, la posibilidad de un desmarque de la disciplina y de la division del trabajo arte o comunicacion para producir imagenes no era facil, sin embargo, el video me permitio desarrollar una escritura autoral in progress y traducir el anhelo textual a un cuerpo audiovisual in extenso.
|
2022-12-14T04:17:15.815Z
|
13,888,284 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.13053/cys-18-4-2059",
"MAG": "2054854926",
"PubMedCentral": null
},
"license": "CCBYNC",
"status": "GREEN",
"url": "https://rgu-repository.worktribe.com/preview/824284/MORENO-GARCIA%202014%20Fast%20and%20efficient%20palmprint.pdf"
}
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In some fields like forensic research, experts demand that a found sample of an individual can be matched with its full counterpart contained on a database. This found sample may present several characteristics that make this matching more difficult to perform, such as distortion and most importantly, a very small size. Several solutions have been presented intending to solve this problem, however, big computational effort or low recognition rate is obtained. In this paper, we present a fast, simple and efficient method to relate a small sample of a partial palmprint to a full one using elemental optimization processes and a voting mechanic. Experimentation shows that our method performs with a higher recognition rate than the state of the art method, when trying to identify palmprint samples with a radius as small as 2.64 cm.
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2022-11-17T18:15:01.268Z
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