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130,680,297 |
{
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"DOI": "10.1306/BDFF7552-1718-11D7-8645000102C1865D",
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|
The Uinta and Paradox basins in eastern Utah contain most of the state's oil and gas fields. Saline water is normally co-produced during the production of liquid and gaseous hydrocarbons from these fields. This study (1) characterized the chemical composition and salinity of the co-produced waters from the two basins; (2) determined the vertical and lateral changes in their salinities and chemical compositions, and the probable causes for these changes; (3) postulated flow paths and barriers for both oil and water; (4) evaluated potential economic uses for these saline waters.
|
2022-02-09T14:06:04.066Z
|
61,134,709 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.3182/20100712-3-FR-2020.00015",
"MAG": "1981778450",
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"url": null
}
|
Abstract Automated reasoning techniques are gaining popularity in administrative and legal fields. In particular, they are crucial for situations in which a huge number of heterogeneous reasoning rules must be taken into account. They allow both ensuring the coherence of the system and making the decision process equitable and more efficient. The National Family Benefits Fund of the Grand-Duchy of Luxembourg is responsible for the attribution of allowances to more than 160,000 individuals whose cases, due to the peculiarity of the local economy based on foreign laborers, and given the European and bilateral agreements between countries, pertain to different legislations. Accordingly, the Fund has decided the development of a customized decision support system, named Cadral, for processing allowance applications. The knowledge of the system is contained into decision rules that express administrative procedures used for processing the applications. An intuitive formalism has been set up for the rules, along with an easy-to-use editor, so that a non-computer specialized user can update the system, according to the evolution of the law. The inference engine is based on the Soar forward-chaining architecture. In addition, links to a legal database, used in connection with the reasoning trace of the system, allows exhibiting a legal justification of the resulting decisions.
|
2022-08-20T18:43:40.887Z
|
133,803,907 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1127/NJGPA/233/2004/69",
"MAG": "2744071800",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Taking into account the difficulty in defining the relationship between large mammal faunas from the Italian peninsula and France on the basis of the biochronological setting proposed to date, a multivariate analysis was carried out to test the affinity between the Italian and French Pliocene-Middle Pleistocene local faunas (LFAs). The analysis points out a high similarity between the Italian early Villafranchian and French Ruscinian LFAs and a relatively good homogeneity between the Italian and French middle Villafranchian LFAs as well as among the latest Early Pleistocene LFAs that show a transitional character, whereas the Middle Pleistocene LFAs show a low degree of similarities because of their provincialism. Zusammenfassung: Aufgrund der Schwierigkeiten, Beziehungen zwischen den Großsäugerfaunen des italienischen Stiefels und Frankreichs unter Einbeziehung ihrer aktuellen Datierung zu definieren, wurde eine multivariate Statistik zwischen den pliozänen bis mittelpleistozänen italienischen und französischen Lokalfaunen (LFAs) durchgeführt. Diese Analyse ergibt eine große Ähnlichkeit zwischen den italienischen frühen Villafranchiumund den französischen Ruscinium-Faunen; des weiteren eine relativ gute Übereinstimmung zwischen den italienischen und französischen Mittel-Villafranchium-Lokalfaunen und auch noch zwischen den Lokalfaunen aus dem jüngsten Unter-Pleistozän, letztere mit Übergangscharakter, wogegen die Mittel-Pleistozän-Lokalfaunen aufgrund ihres Provinzialismus weniger Ähnlichkeiten zeigen. 0077-7749/04/0233-0069 $ 8.50 © 2004 E. Schweizerbart’sche Verlagsbuchhandlung, D-70176 Stuttgart 836-palombo-17.1. 02.07.2004 15:11 Uhr Seite 69 (Schwarz Bogen) (c) 2015 www.schweizerbart.com DOI:10.1127/njgpa/233/2004/69
|
2022-08-25T12:51:45.344Z
|
88,887,210 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1182/BLOOD.V122.21.4468.4468",
"MAG": "2528659141",
"PubMedCentral": null
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"license": null,
"status": null,
"url": null
}
|
Allogeneic hematopoetic stem cell transplantation (HSCT) is the treatment of choice for a variety of hematologic malignancies. Graft-versus-Host disease (GvHD) is a key contributor to treatment related morbidity and mortality and consequently limits the efficacy of allogeneic HSCT. Interleukin 10 (IL-10) is a well-known cytokine with immunoregulatory and anti-inflammatory properties, also important in context of GvHD. B cells have been described as potent IL-10 producers in various situations. Here we show how host as well as donor derived B cells contribute to GvHD amelioration through IL-10 production.
We address the role of IL-10 in GvHD in an acute murine MHC mismatch model: Mice on a C57BL/6 background received bone marrow and CD90+ T cells from mice on a BALB/c background or vice versa. Transplantation experiments with IL-10 deficient donor or host cells clearly show the importance of donor derived IL-10 in general. To further dissect the cells contributing to IL-10 production in this situation we employed an IL-10 knock-in reporter mouse in which expression of eGFP is under control of the Il-10 locus. Lethal irradiation as used in the conditioning regiment before transplantation revealed B cells as major contributors of host derived IL-10. In addition, transfer of cells from reporter mice into preconditioned recipients showed also donor B cells as contributors to IL-10 production. A phenotypical characterization of the eGFP+ B cells exhibited a CD1d+TIM-1+CD5int phenotype, in line with immunoregulatory B cells. To finally confirm the relevance of B cells derived IL-10 in GvHD, we employed B6.B-IL-10-/- mice that have a B cell specific IL-10 knock-out as donors or recipients. Here we found a reduced survival associated with the incapability of the B cells to produce IL-10 in both cases.
Taken together, our results provide new insights in the mechanisms and the variety of cells contributing to the course of GvHD. An improved understanding of these aspects might help to pave the way for new treatment options to overcome current limitations of allogenic HSCT.
Disclosures: No relevant conflicts of interest to declare.
|
2022-02-10T20:06:53.139Z
|
122,878,509 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1063/1.4766284",
"MAG": "2070840530",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
We report on an in-situ oxidation effect during annealing of SiO2/SiO1.0N0.23 multilayers prepared by plasma enhanced chemical vapour deposition (PECVD). This in-situ oxidation leads to an undesired growth of the tunneling oxide and also affects the silicon nanocrystal (SiNC) size control, i.e., a NC shrinkage. The origin of this oxidation is identified to be a “quasi-wet” oxidation by O–H groups incorporated in the PECVD-SiO2 barrier layers. By varying the thickness of the PECVD-SiO2 layer underneath a single SiO1.0N0.23 layer, the extent of NC oxidation is tuned. The shrinkage of SiNCs is proven by a blueshift of the photoluminescence peak position as well as by transmission electron microscopy.
|
2022-09-23T09:25:23.951Z
|
35,229,108 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3748/WJG.V12.I25.4106",
"MAG": "1586489795",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Small bowel stenosis is a serious complication of intestinal anisakiosis. The aim of this report is to investigate whether severe stenosis of the small intestine can be conservatively managed. We treated two patients with severe stenosis of the small intestine caused by anisakiosis. Surgical intervention was eventually performed on the 23rd and 35th in the hospital, respectively. Histopathological examination of the resected specimens revealed that the intestinal wall had been completely damaged by the inflammatory reaction of anisakiosis, and that the damage was irreversible, thereby suggesting that laparotomy is needed in cases of severe small bowel stenosis caused by intestinal anisakiosis, even if a long period of conservative treatment for the intestinal anisakiosis allowed the patient to pass successfully through the acute phase.
|
2022-12-12T21:51:31.248Z
|
122,209,956 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1086/501010",
"MAG": "2039032424",
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
We report a study of the spectra and structure of the accretion disk of the dwarf nova V2051 Ophiuchi while the star was in an unusual faint brightness state during 1996. The differences between the UV resonant lines and continuum disk surface brightness distributions indicate a vertically extended disk with the emission from these lines arising from the upper atmospheric layers. Distinct emission along the stream trajectory suggests the occurrence of gas stream overflow. Spatially resolved spectra show that the lines are in emission at all disk radii. The Balmer decrement becomes shallower with increasing radius. The FWHMs of the emission lines show differences with respect to that expected for a gas in Keplerian rotation, and the line intensities drop with a radial dependency of I ∝ R-1.78. The uneclipsed light contributes about 5%-10% of the total flux, and its spectrum is dominated by a Balmer jump and strong lines in emission. Broad absorption bands, possibly due to Fe II, are present in the spectra of the disk side farther away from the secondary star, suggesting it arises from absorption by a extended gas region above the disk; the differences between the spectra of the hemisphere farther from and nearer to the secondary star are interpreted in terms of chromospheric emission from a disk with a nonnegligible opening angle (limb-brightening effect). Stellar atmosphere model fits to the extracted white dwarf spectrum lead to a temperature TWD = 9500 K and a distance d = 67 pc if the inner disk is opaque or d = 92 pc if the inner disk is optically thin.
|
2022-12-15T05:33:35.242Z
|
36,172,706 |
{
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"ArXiv": null,
"DOI": "10.1097/00005650-200007000-00005",
"MAG": "2040264449",
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"license": null,
"status": null,
"url": null
}
|
BACKGROUND AND OBJECTIVES
The number of US residents with limited English proficiency (LEP) is 14 million and rising. The goal of this study was to estimate the effects of LEP on physician time and resource use.
DESIGN
This was a prospective, observational study.
SETTING AND SUBJECTS
The study included 285 Medicaid patients speaking English (n = 112), Spanish (n = 62), or Russian (n = 111) visiting the General Medicine and Family Practice Clinics at the UC Davis Medical Center in 1996-1997 (participation rate, 85%). Bilingual research assistants administered patient questionnaires, abstracted the medical record, and conducted detailed time and motion studies.
MAIN OUTCOME MEASURES
We used seemingly unrelated regression models to evaluate the effect of language on visit time, controlling for patient demographics and health status, physician specialty, visit type, and resident involvement in care. We also estimated the effect of LEP on cross-sectional utilization of health care resources and adherence to follow-up with referral and testing appointments.
RESULTS
The 3 language groups differed significantly by age, education, and reason for visit but not gender, number of active medical conditions, physical functioning, or mental health. Physician visit time averaged 38+/-20 minutes (mean+/-SD). Compared with English-speaking patients and after multivariate adjustment, Spanish and Russian speakers averaged 9.1 and 5.6 additional minutes of physician time, respectively (P <0.05). The language effect was confined largely to follow-up visits with resident physicians (house staff). Compared with English speakers, Russian speakers had more referrals (P = 0.003) and Spanish speakers were less likely to follow-up with recommended laboratory studies (P = 0.031).
CONCLUSIONS
In these academic primary care clinics, some groups of patients using interpreters required more physician time than those proficient in English Additional reimbursement may be needed to ensure continued access and high-quality care for this special population.
|
2022-12-16T12:14:21.425Z
|
14,055,371 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1371/journal.pone.0082907",
"MAG": "2037179471",
"PubMedCentral": "3865095"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0082907&type=printable"
}
|
Background Numerous studies examining the relationship between Cyclooxygenase-2 (COX-2) immunoexpression and clinical outcome in osteosarcoma patients have yielded inconclusive results. Methods We accordingly conducted a meta-analysis of 9 studies (442 patients) that evaluated the correlation between COX-2 immunoexpression and clinical prognosis (death). Pooled odds ratios (OR) and risk ratios (RR) with 95% confidence intervals (95% CI) were calculated using the random-effects or fixed-effects model. Results Meta–analysis showed no significant association between COX-2 positivity and age, gender, tumor location, histology, stage, metastasis or 90% necrosis. Conversely, COX-2 immunoexpression was associated with overall survival rate (RR=2.12; 95% CI: 1.10–3.74; P=0.009) and disease-free survival rate (RR=1.63; 95% CI: 1.17–2.28; P=0.004) at 2 years. Sensitivity analysis performed by omitting low quality studies showed that the pooled results were stable. Conclusions COX-2 positivity was associated with a lower 2-year overall survival rate and disease-free survival rate. COX-2 expression change is an independent prognostic factor in patients with osteosarcoma.
|
2022-12-19T05:14:44.838Z
|
235,676,704 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/jcph.1864",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
Pediatric safety evaluations are an essential part of a pediatric drug development program. Communication of the results of these safety evaluations is primarily accomplished by labeling of the drug either during the initial pediatric drug development program, or during the postmarketing period after drug approval for pediatric patients. During drug development, the dose–adverse drug event (ADE) relationship is an important part of the evaluation, but a consideration for pediatric ADEs that are unrelated to drug dosage must be maintained. Examples of dose‐related and non–dose‐related ADEs are presented. The failure to label a product for pediatric use has been safety related for a number of development programs. The US Food and Drug Administration's Pediatric Advisory Committee is a primary source of the pediatric postmarketing safety review and has been associated with a number of labeling changes through its ongoing review process. Pediatric drug safety remains a critical part of the assessment of dose‐effect relationship in the pediatric patient population during the drug development and postmarketing surveillance process.
|
2022-12-20T21:45:32.625Z
|
24,089,924 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/ICRC.2017.8123660",
"MAG": "2773744293",
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},
"license": null,
"status": null,
"url": null
}
|
Considerable efforts have been devoted to the design of low-power digital electronics. However, after decades of improvements and maturation, CMOS technology could face an efficiency ceiling. This is due to the trade-off between leakage and conduction losses inherent to transistors. Consequently, the lowest dissipation per operation remains nowadays few decades higher than the theoretical Landauer''s limit (3 zJ at 300 K). Adiabatic CMOS architectures are good candidates for reducing the dynamic losses. But adiabatic operation reduces operating frequency, thus exacerbating the leakage loss. Consequently, transistors could not be the appropriate support for adiabatic logic. In this paper, we bring in a new paradigm for computation. The elementary device which replaces transistor is based on coupled moving masses suspended by springs. Such objects can be fabricated with MEMS in order to provide a relatively high computing speed (in the order of 1 MHz for a micrometer-scaled device). In this paradigm, the logic states are encoded mechanically instead of electrically. The computation is performed by means of electrostatic interactions between the moving elements. We show how they can be arranged in order to create combinational logic gates that can be cascaded. Information is injected and extracted electrically, thus allowing compatibility with conventional circuits. We estimate resistive and damping dissipation of the system via electromechanical simulations, for the case of an AND gate. When the gate is driven adiabatically, the energy per operation drops in the range of the attojoule, even with a micrometer-scaled elementary device. This dissipation almost vanishes for lower frequencies of operation. This suggests that electromechanical adiabatic computing (EMAC) could be able to approach Landauer''s limit. EMAC could be valuable for devices operating under high energy constrains with low computing power requirements, such as future massively spread environmental sensors.
|
2022-12-23T02:20:57.232Z
|
76,198,630 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5795/JJSCC.33.563",
"MAG": "2321013838",
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},
"license": null,
"status": null,
"url": null
}
|
子宮原発のepithelioid leiomyosarcomaの1例を経験したので報告する.症例は82歳の女性で, 低血糖による意識障害を主訴に内科を受診し, 画像診断により下腹部腫瘤を指摘され, 当科へ紹介受診となった.開腹術で子宮壁から発生した腫瘍であることが確認され子宮全摘出術ならびに両側卵巣摘出術を施行した.腫瘍部分の捺印細胞診では, 出血性背景のもとに軽度の大小不同を伴う多稜形ないし短紡錘形の腫瘍細胞を認め, 核は類円形ないし楕円形で, 一部の細胞では分葉状であり, クロマチンは顆粒ないし粗網状で, 明らかな核小体は観察されなかった.細胞質は辺縁明瞭でcyanophilicで比較的広く厚かった.また多核細胞, 巨細胞も散見された.病理組織学的には, 豊富な細胞質を有する短紡錘形細胞と多角形細胞の2種類の細胞が浸潤性に増殖しており, 大部分は明るい胞体を有する類上皮様細胞よりなり, 核分裂像は平均10/10HPF認められた.また免疫組織化学的検索では, vimentin, desminがともに陽性となり, cytokeratinが巣状に陽性を示した.以上より子宮に原発したepithelioid leiomyosarcomaと診断した.
|
2022-02-11T06:37:06.776Z
|
109,877,481 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/bate.201010028",
"MAG": "1595797462",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Mit der Planung und Errichtung des Neubaus für die Kultur‐ und Gesellschaftswissenschaftliche Fakultät (KGW) der Universität Salzburg entsteht ein Gebäude, das dank seiner exponierten und herausfordernden Architektur, aber auch wegen der Problematik des anstehenden Baugrunds höchste Anforderungen an die Aus‐ und Durchbildung des gesamten Tragwerks stellt, über das zu berichten lohnt. Dabei bedingen die unterschiedlichsten gestalterischen und funktionalen Anforderungen des Gebäudes bauteilkonkret spezifische Antworten, die frühzeitig in der Planung an zudenken und bezüglich ihrer Wirtschaftlichkeit zu bewerten waren. Die entwurfsbedingt weitgehende Freistellung der mittleren Geschosse des Baus von Stützelementen erfordert die Ausbildung weitspannender Tragwerke in den Obergeschossen, wobei hier nur begrenzt Platz für die Erzielung statischer Höhen zur Verfügung stand. Andererseits mussten die konzentriert angreifenden, beträchtlichen Lasten der Obergeschosse mit weit gespannten Gründungskonstruktionen verteilt und in den begrenzt tragfähigen Baugrund abgeleitet werden.
|
2022-03-26T05:08:47.542Z
|
249,833,599 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4028/p-m7918n",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This paper discusses in detail Recent Trends in Tribology of Polymers, Polymer Composites and Polymer Nanocomposites, since they have certain properties unachievable with traditional materials. Important commercial materials used have been given. Some unique properties and applications of PPCs have been outlined. Carbon Nanotubes have been discussed in detail. Some explanation of the synthesis and experimental results of Cellulose-based hydrogels as reported in the literature , have been discussed in detail.
|
2022-06-29T19:14:20.079Z
|
107,657,595 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2172/6747267",
"MAG": "310509203",
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},
"license": null,
"status": "GREEN",
"url": "https://www.osti.gov/biblio/6747267"
}
|
Achieving acceptable filtration efficiency of gas-entrained solid particles has been an important industrial problem. A high dust collection efficiency is essential for many industrial operations either to avoid the possibility of a serious health hazard or to recover valuable solid materials which would otherwise be lost. There is renewed interest in using fibrous and fluidized-bed filters to remove dust from the hot combustion gases from a pressurized fluidized-bed combustor. Such gases may be used to drive a turbine system for power generation. The literature available on the use of fixed-bed and fluidized-bed filters is reviewed to assess our present ability to design efficient and reliable filtration units for hot, compressed gases. The basic mechanisms for solids collection from gas streams are: gravity settling, direct interception, inertial impaction, Brownian diffusion, and thermal separation. The guiding principles of these mechanisms and the characteristic parameters which control the collection of particles are summarized. Calculation procedures are enumerated for estimating total or overall collection efficiency of a single filter unit (cylinder or sphere) and that of a filter consisting of an assembly of individual filter units. Most investigations were at room temperature and 1-atm pressure, and the probable effect of these two variables (temperaturemore » and pressure) on the solids collection efficiency has been analyzed theoretically. The use of fluidized beds in series and containing bed material which can be electrically charged appears to be promising for flue-gas cleaning. It is possible to develop an efficient filter that will match a specific requirement for a given system. Much theoretical and experimental research and development work will be needed for successful understanding and operation of efficient filter systems.« less
|
2022-07-04T21:06:03.528Z
|
172,060,961 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.21143/JHP.VOL24.NO5.1052",
"MAG": "2737380084",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Pasal 23 UUD 1945 merupakan suatu "Communis Opinio Doktorum" di bidang Keuangan Negara. Pasal tersebut tidak hanya mengatur keuangan negara yang bersumber dari APBN. Itu dapat dibuktikan dari bunyi Pasal 23 ayat (4) dan dari risalah pasal 23 yang disusun oleh M. Yamin. Untuk memberikan pengertian dan luas lingkup keuangan negara dalam pasal tersebut diperlukan pendekatan-pendekatan yang berbeda. Karangan ini mencoba menjelaskan Bab VII hal keuangan pasal 23 UUD 1945 melalui pendekatan yuridis formal dan filosofis.
|
2022-11-11T07:32:15.597Z
|
235,449,148 |
{
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"ArXiv": null,
"DOI": "10.1177/13524585211023345",
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},
"license": "CCBYNC",
"status": "HYBRID",
"url": "https://doi.org/10.1177/13524585211023345"
}
|
Background: Advanced magnetic resonance imaging (MRI) methods can provide more specific information about various microstructural tissue changes in multiple sclerosis (MS) brain. Quantitative measurement of T1 and T2 relaxation, and diffusion basis spectrum imaging (DBSI) yield metrics related to the pathology of neuroinflammation and neurodegeneration that occurs across the spectrum of MS. Objective: To use relaxation and DBSI MRI metrics to describe measures of neuroinflammation, myelin and axons in different MS subtypes. Methods: 103 participants (20 clinically isolated syndrome (CIS), 33 relapsing-remitting MS (RRMS), 30 secondary progressive MS and 20 primary progressive MS) underwent quantitative T1, T2, DBSI and conventional 3T MRI. Whole brain, normal-appearing white matter, lesion and corpus callosum MRI metrics were compared across MS subtypes. Results: A gradation of MRI metric values was seen from CIS to RRMS to progressive MS. RRMS demonstrated large oedema-related differences, while progressive MS had the most extensive abnormalities in myelin and axonal measures. Conclusion: Relaxation and DBSI-derived MRI measures show differences between MS subtypes related to the severity and composition of underlying tissue damage. RRMS showed oedema, demyelination and axonal loss compared with CIS. Progressive MS had even more evidence of increased oedema, demyelination and axonal loss compared with CIS and RRMS.
|
2022-11-25T00:43:26.926Z
|
3,200,165 |
{
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"ArXiv": null,
"DOI": "10.1609/hcomp.v2i1.13137",
"MAG": "1487101415",
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},
"license": null,
"status": "BRONZE",
"url": "https://ojs.aaai.org/index.php/HCOMP/article/download/13137/12985"
}
|
Comparative genomics is a field of research that aims to provide us accurate mappings between the genetic material of multiple species. These techniques are useful for biomedical research and evolutionary studies. We present Phylo and Open-Phylo, an open citizen science platform and human computing-game for comparative genomic studies that reached more than 300,000 users.
|
2022-12-09T13:39:47.760Z
|
122,597,380 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1063/1.4890579",
"MAG": "2090972770",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Solution-processed ultra-thin (∼3 nm) zinc tin oxide (ZTO) thin film transistors (TFTs) with a mobility of 8 cm2/Vs are obtained with post spin-coating annealing at only 350 °C. The effect of light illumination (at wavelengths of 405 nm or 532 nm) on the stability of TFT transfer characteristics under various gate bias stress conditions (zero, positive, and negative) is investigated. It is found that the ΔVth (Vthstress 3400 s − stress 0 s) window is significantly positive when ZTO TFTs are under positive bias stress (PBS, ΔVth = 9.98 V) and positive bias illumination stress (λ = 405 nm and ΔVth = 6.96 V), but ΔVth is slightly negative under only light illumination stress (λ = 405 nm and ΔVth = −2.02 V) or negative bias stress (ΔVth = −2.27 V). However, the ΔVth of ZTO TFT under negative bias illumination stress is substantial, and it will efficiently recover the ΔVth caused by PBS. The result is attributed to the photo-ionization and subsequent transition of electronic states of oxygen vacancies (i.e., V...
|
2022-12-21T09:26:59.062Z
|
128,490,219 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.1139/T08-066",
"MAG": "2115546212",
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},
"license": null,
"status": null,
"url": null
}
|
The soil specimen in a centrifuge model is subject to spatial variability depending on the method of sample preparation and the stress field induced by the centrifugal acceleration, even though it is intended to be uniformly pre- pared. In contrast to extensive measurements for studying the variability of in situ soil properties, soil variability in centri- fuge models, especially that which is based on data at very close sampling distances, is less understood. In this paper, the variability of soil density in two centrifuge models is presented. Random field theory is adopted to characterize the spatial soil variability in the two centrifuge models. The importance of taking spatial variability parameters as a model similarity requirement in centrifuge model design is illustrated and discussed. It is demonstrated that, although centrifuge models of different sizes can be designed to simulate the same prototype, the prototypes these models actually represent are not iden- tical in terms of soil spatial variability. To achieve similarity in spatial variability between a centrifuge model and its pro- totype, one may need to control either the point coefficient of variation or the scale of fluctuation of the model soil so that the coefficients of variation of the spatially averaged soil property in the model and the prototype are the same.
|
2022-12-24T17:51:31.744Z
|
216,464,499 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.24988/ije.202035114",
"MAG": "3013174696",
"PubMedCentral": null
},
"license": "CCBYNC",
"status": "GOLD",
"url": "https://dergipark.org.tr/tr/download/article-file/1028752"
}
|
Bu arastirmada sosyal sermayenin stratejik ceviklik uzerindeki etkisi incelenmistir. Bu baglamda nedensel tarama deseninde nicel veri analizine dayali bir arastirma yontemi gerceklestirilmistir. Veri toplamak amaciyla Bitlis ilinde faaliyette bulunan 38 KOBI’nin yonetici ve sahipleriyle bir anket calismasi gerceklestirilmistir. Arastirmanin hipotezlerini test etmek icin elde edilen veriler SPSS programi yardimiyla coklu regresyon analizlerine tabi tutulmustur. Yapilan analizler sonucunda, sosyal sermaye alt boyutlarinin stratejik cevikligin alt boyutlari uzerinde pozitif etkiye sahip oldugu gorulmustur. Arastirmanin sosyal sermaye ve stratejik ceviklik iliskisini inceleyen ilk arastirma olmasi bakimindan literature katki sunmasi beklenmektedir.
|
2022-09-30T16:36:42.162Z
|
10,553,374 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1159/000224874",
"MAG": "2063422018",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Introduction: The innervation of the membranous urethra (MU) is still under debate. We analysed the functional effects of electrostimulation of the rhabdosphincter branch of the pelvic nerve (RBP) on the MU in a standardized male rabbit model, paying attention both to the efferent and the possible afferent effects of stimulation. Material and Methods: Six male rabbits (chinchilla bastards) were included in this study. Pudendal nerve branches as well as pelvic nerve branches were exposed bilaterally in all animals. Randomized electrostimulation trials of both the pudendal nerve fibres and the RBP were carried out using a biphasic signal (0.3 mA, 200 μs). The stimulation frequency ranged from 10 to 40 Hz in a randomized pattern. Changes in MU pressure were measured urodynamically. The pressure changes occurring as a result of stimulation were compared in both nerve structures. At the end of the stimulation trial, the RBP and the pudendal nerve were dissected at different positions before repeating the stimulation and the MU pressure recording. Results: The mean MU baseline pressure without stimulation was 24 cm H2O (range 21–27) in all animals. During unilateral pudendal stimulation, the mean pressure response rose by highly significant values (p < 0.005) compared to baseline. The pressure response was frequency dependent. Stimulation of the RBP resulted in a small but significant change of the MU pressure in the lower frequency range (10 and 20 Hz) (p > 0.05). On performing stimulation at higher frequencies, there was no significant difference from baseline. The pressure response of the MU during stimulation of the intact RBP did not differ significantly from the response after dissection of the RBP. However, after dissecting the pudendal nerve, the MU pressure response to RBP stimulation was diminished. Conclusion: Our results confirm the primacy of the pudendal nerve in the innervation of the MU. Stimulation of the RBP, however, may produce an afferent signal which is transmitted to the pudendal nerve, thus resulting in a pressure increase of the MU and contributing towards continence. We showed the importance of the RBP to maintain full urinary continence in rabbits. Our results suggest that substantially higher continence rates can be achieved through a nerve-sparing procedure in radical prostatectomy. Nerve-sparing radical prostatectomy incidentally also protects the RBP from injury.
|
2022-08-28T03:41:45.578Z
|
154,160,852 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2202/1935-1704.1398",
"MAG": "2034000933",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
We study two-player all-pay contests in which there is a positive probability of a tied outcome. We show that the players' efforts in equilibrium do not depend on the expected prize in the case of a tie given that this prize is smaller than the prize for winning. The implications of this result are twofold. First, in symmetric one-stage contests, the designer who wishes to maximize the expected total effort should not award a prize in the case of a tie which is larger than one-third of the prize for winning. Second, in multi-stage contests, the designer should not limit the number of stages (tie-breaks) but should allow the contest to continue until a winner is decided.
|
2022-12-04T17:28:28.799Z
|
1,049,198 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1128/JB.01989-12",
"MAG": "2055432654",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
ABSTRACT Enterotoxigenic Escherichia coli (ETEC) is a bacterial pathogen that causes diarrhea in children and travelers in developing countries. ETEC adheres to host epithelial cells in the small intestine via a variety of different pili. The CS1 pilus is a prototype for a family of related pili, including the CFA/I pili, present on ETEC and other Gram-negative bacterial pathogens. These pili are assembled by an outer membrane usher protein that catalyzes subunit polymerization via donor strand complementation, in which the N terminus of each incoming pilin subunit fits into a hydrophobic groove in the terminal subunit, completing a β-sheet in the Ig fold. Here we determined a crystal structure of the CS1 major pilin subunit, CooA, to a 1.6-Å resolution. CooA is a globular protein with an Ig fold and is similar in structure to the CFA/I major pilin CfaB. We determined three distinct negative-stain electron microscopic reconstructions of the CS1 pilus and generated pseudoatomic-resolution pilus structures using the CooA crystal structure. CS1 pili adopt multiple structural states with differences in subunit orientations and packing. We propose that the structural perturbations are accommodated by flexibility in the N-terminal donor strand of CooA and by plasticity in interactions between exposed flexible loops on adjacent subunits. Our results suggest that CS1 and other pili of this class are extensible filaments that can be stretched in response to mechanical stress encountered during colonization.
|
2022-12-15T00:07:13.080Z
|
97,146,271 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.1002/BSCB.19850941104",
"MAG": "2091966858",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The X-ray structure of N-Piv-D-Phe-L-Pro-NHEt(C21H31N3O3) was solved by direct methods from diffractometer data. Crystallized from diethylether solution, orthorhombic, space group P212121, a = 19.336(24) b = 16.818(18), c = 6.488(7)A, V = 2110(4)A3, Dx = 1.18 g cm−3 for Z = 4. MoKα radiation, λ = 0.71069 A; μ = 0.85 cm−1, F(000) = 808. Final R value = 0.084 for 1307 observed reflections.
The peptide backbone is in the all-transoid configuration and takes the type II β bend conformation characterized by ϕ1,Ψ1,ϕ2 and Ψ2 values of 61.8°, -123.2°, -84.8° and 0.8° respectively and by an intramolecular hydrogen bond involving the ethylamide NH and the pivaloyl carboxyl oxygen. The phenyl group stacks over the central amide bond in the “extended-to-oxygen” rotamer, thereby facing the prolyl side chain.
|
2022-12-16T02:31:23.291Z
|
1,524,943 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1155/2009/902326",
"MAG": "2135894269",
"PubMedCentral": "2804038"
},
"license": "CCBY",
"status": "GOLD",
"url": "http://downloads.hindawi.com/journals/ijbi/2009/902326.pdf"
}
|
Breast cancer is a serious threat worldwide and is the number two killer of women in the United States. The key to successful management is screening and early detection. What follows is a description of the state of the art in screening and detection for breast cancer as well as a discussion of new and emerging technologies. This paper aims to serve as a starting point for those who are not acquainted with this growing field.
|
2022-12-18T12:24:01.134Z
|
240,965,264 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5149/northcarolina/9781469653709.003.0002",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This chapter examines the rise of organized American tackle football for high school and college students in the late nineteenth and early twentieth centuries. The sport became most prominently associated with white, Anglo-Saxon, protestant students at elite colleges and universities. Early safety debates turned on whether football’s physical dangers were uncivilized and “brutish,” or whether exposure to its risks fostered American ideals of civilized manliness. These ideals were in turn intertwined with dominant understandings of race, gender, and national identity. School administrators and other leaders, including President Theodore Roosevelt, saw football as preparing boys for future business and military leadership. As a consequence, they contended that the sport’s perceived violence was civilized and conferred moral benefits upon players. By the early twentieth century, football was firmly established in elite American colleges and expanding at the high school level.
|
2022-01-27T03:31:43.745Z
|
184,575,105 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1515/fjsb-2004-0118",
"MAG": "2562624130",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Veröffentlichungen sozialer Bewegungen werden von staatlichen Archiven, die immer noch in erster Linie an .amtlichem' Schriftgut orientiert sind, nur lückenhaft gesammelt. So genannte graue Literatur und illegalisierte Schriften finden selten den Weg in institutionalisierte Sammlungen. Bewegungsarchive, d. h. Archive, die von sozialen Bewegungen selbst gegründet und unterhalten werden, sind aber nicht nur deshalb unverzichtbarer Baustein in der kritischen Auseinandersetzung mit Bewegungsgeschichte, weil sie über einzigartige Dokumente verfügen. Die meist ehrenamtlichen Bewegungsarchivare und -archivarinnen verstehen sich oft selbst als Teil politischer Bewegungen und verfügen über ein wertvolles Wissen über die sozialen Kämpfe wenn auch ihre Tätigkeit des Sammeins und Abheftens in den Bewegungen oft nicht sehr angesehen ist.
|
2022-02-08T11:51:24.178Z
|
62,179,915 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1177/016555158200400505",
"MAG": "2066179618",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A storage and retrieval system for Charged Particle Nuclear Reaction Data (CPND) has been designed and implemented. CPND is a typical case of raw data produced in scientific research activities. The system has the architecture of an inter mediate system which lies between an IR system and a Data Base Management System (DBMS). Data input to the system are coded by a "data language" of free format. A doubly inverted file structure is incorporated into the system for both information representation and indexing. The implications of this system in the context of scientific information systems in general is discussed.
|
2022-06-18T13:11:32.284Z
|
80,139,309 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1051/RADIOPRO/19862102105",
"MAG": "2750078922",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
L’utilisation des donnees mensuelles d’exposition externe des travailleurs se situe a differents niveaux : l’individu isole, l'individu dans son groupe, le groupe en soi, enfin les groupes entre eux.Dans chaque cas, des indicateurs statistiques (dose annuelle, dose collective annuelle, dose annuelle moyenne, etc.) sont employes pour resumer une situation individuelle ou collective. La pertinence et l’efficacite des indicateurs sont discutees dans une perspective de gestion du risque radiologique individuel et collectif. La necessite de recourir aux distributions statistiques apparait des qu’il faut repondre a un probleme d’estimation, tant au plan individuel, c’est le cas des donnees manquantes, qu'au plan du groupe pour les doses annuelles des individus le composant ou pour les doses recues par ceux-ci sur une certaine periode qui peut etre celle de la vie professionnelle.
|
2022-07-11T02:32:16.312Z
|
27,970,192 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1006/JMBI.2000.4205",
"MAG": "2577105955",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
We have previously shown the existence of two DNA-binding sites on the globular domain of H5 (termed GH5), both of which are required for nucleosome organisation, as judged by the protection of a 166 bp chromatosome intermediate during micrococcal nuclease digestion of chromatin. This supports a model in which GH5 contacts two duplexes on the nucleosome. However, studies of a nucleosome assembled on the 5 S rRNA gene have argued against the requirement for two DNA-binding sites for chromatosome protection, which has implications for the role of linker histones. We have used this proposed difference in the requirement for a second site on the globular domain in the two models as a means of investigating whether bulk and reconstituted 5 S nucleosomes are indeed fundamentally different. GH5 protects a 166 bp chromatosome in both "bulk" and 5 S systems, and in both cases protection is abolished when all four basic residues in site II are replaced by alanine. Binding to four-way DNA junctions, which present a pair of juxtaposed duplexes, is also abolished. Single mutations of the basic residues did not abolish chromatosome protection in either system, or binding to four-way junctions, suggesting that the residues function as a cluster. Both bulk and 5 S nucleosomes thus require a functional second DNA-binding site on GH5 in order to bind properly to the nucleosome. This is likely to reflect a similar mode of binding in each case, in which two DNA duplexes are contacted in the nucleosome. There is no indication from these experiments that linker histones bind fundamentally differently to 5 S and bulk nucleosomes.
|
2022-09-14T22:29:33.295Z
|
124,273,441 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2307/3212207",
"MAG": "2327983403",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In a previous paper [2] the author has studied the single-server queue with non-homogeneous Poisson input and general service time, with particular emphasis on the case when the parameter of the Poisson input is of the form
|
2022-09-15T09:41:22.026Z
|
211,119,865 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/ICAIT47043.2019.8987408",
"MAG": "3006526018",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Wireless Sensor Networks is growing very fast in today’s era. The ideas of of this circuitry’s digital is, wireless transceiver, and micro electro-mechanical systems (MIELMESY) has made it possible that all the combined way of occasion, data firefight, wireless tinkle and power supply will be available into an low-cost inch scale device. Conjunctively, the torque and inexpensive WSN consist of thousands of these nodes and it has attracted much customer retention. Balance Scale sensor devices have been designed to work with limited power requirements for longest times. One of the hard-fought challenges that had been faced by the WSNs is their energy performant with an increase in the network engorged at any point of time number of sensor nodes can amalgamate or disconnect the network and also the torque of the network is sweepingly high.
|
2022-12-10T21:52:52.990Z
|
17,513,478 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3390/cancers9020016",
"MAG": "2586689382",
"PubMedCentral": "5332939"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.mdpi.com/2072-6694/9/2/16/pdf?version=1486457938"
}
|
EGF signaling is a well-known oncogenic pathway in animals. It is also a key developmental pathway regulating terminal and dorsal-ventral patterning along with many other aspects of embryogenesis. In this review, we focus on the diverse roles for the EGF pathway in Drosophila embryogenesis. We review the existing body of evidence concerning EGF signaling in Drosophila embryogenesis focusing on current uncertainties in the field and areas for future study. This review provides a foundation for utilizing the Drosophila model system for research into EGF effects on cancer.
|
2022-12-16T12:26:34.003Z
|
24,377,431 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1211/jpp.59.10.0007",
"MAG": "1992003475",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The objectives of this study were to compare two methods for the preparation of bicarbonate buffer, and to compare media prepared with bicarbonate buffer with commonly used biorelevant and pharmacopoeial media in terms of their suitability for dissolution testing. The various media were compared with regard to ease of preparation, robustness and reproducibility of composition. The dissolution of three formulations of a typical Biopharmaceutical Classification System Class II drug (BIXX) was compared in bicarbonate buffer, standard phosphate buffer, a biorelevant buffer (fasted‐state simulating intestinal fluid, FaSSIF) and a modified FaSSIF prepared with bicarbonate buffer. The bicarbonate buffer used for dissolution testing was produced by supplying carbon dioxide to a saline solution (0.9% NaCl, to which 12 or 42 mmol NaOH had been added). The bicarbonate buffer had to be prepared in‐situ, which proved to be time‐consuming, and the pH stability of the bicarbonate buffer could only be maintained under constant CO2 supply. To minimize the mechanical stress caused by inflow and evaporation of gas, the carbon dioxide was supplied above the medium during the dissolution test. Despite taking these measures, use of bicarbonate buffer led to less reproducible dissolution results than the phosphate buffers commonly used to prepare compendial media and FaSSIF, with coefficient of variance values 1.5‐ to 5‐times higher in bicarbonate buffer. It was concluded that although a bicarbonate buffer system would be physiologically relevant for the fasted state in the small intestine, its suitability for dissolution testing is restricted by lack of practicability and poor reproducibility of results.
|
2022-12-21T20:01:29.472Z
|
16,561,726 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1212/NXI.0000000000000194",
"MAG": "2265012467",
"PubMedCentral": "4723135"
},
"license": null,
"status": null,
"url": null
}
|
Objective: To analyze changes in T-helper (Th) subsets, T-regulatory (Treg) cell percentages and function, and mRNA levels of immunologically relevant molecules during a 24-month follow-up after alemtuzumab treatment in patients with relapsing-remitting multiple sclerosis (RRMS). Methods: Multicenter follow-up of 29 alemtuzumab-treated patients with RRMS in the Comparison of Alemtuzumab and Rebif Efficacy in Multiple Sclerosis (CARE-MS) I and CARE-MS II trials. Peripheral blood (PB) samples were obtained at months 0, 6, 12, 18, and 24. We evaluated (1) mRNA levels of 26 immunologic molecules (cytokines, chemokines, chemokine receptors, and transcriptional factors); (2) Th1, Th17, and Treg cell percentages; and (3) myelin basic protein (MBP)–specific Treg suppressor activity. Results: We observed 12 relapses in 9 patients. mRNA levels of the anti-inflammatory cytokines interleukin (IL)–10, IL-27, and transforming growth factor–β persistently increased whereas those of proinflammatory molecules related to the Th1 or Th17 subsets persistently decreased after alemtuzumab administration throughout the follow-up period. PB CD4+ cell percentage remained significantly lower than baseline while that of Th1 and Th17 cells did not significantly change. A significant increase in Treg cell percentage was observed at month 24 and was accompanied by an increase in Treg cell suppressive activity against MBP-specific Th1 and Th17 cells. Conclusions: The long-lasting therapeutic benefit of alemtuzumab in RRMS may involve a shift in the cytokine balance towards inhibition of inflammation associated with a reconstitution of the PB CD4+ T-cell subsets that includes expansion of Treg cells with increased suppressive function.
|
2022-12-30T01:07:29.035Z
|
238,012,477 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.36566/ijhsrd/vol3.iss1/61",
"MAG": "3173154550",
"PubMedCentral": null
},
"license": "CCBYSA",
"status": "GOLD",
"url": "https://ijhsrd.com/index.php/ijhsrd/article/download/61/41"
}
|
Background:For Kendari City, the NO2 concentration in the air measured on Jl.Abdullah Silondae street still below the quality standard. However, the NO2 concentration has increased and decreased based on the results of air monitoring from the Environment and Forestry Service regarding the Air Quality Index which is measured 2 times a year with NO2 parameters in 2017, the first measurement is the value obtained of 1.58 µg / m3 and the second measurement. amounting to 1.57 µg / m3. In 2018 the NO2 value in the first measurement was 4.2 µg / m3 and the second measurement was 5.23 µg / m3. Whereas in 2019 the NO2 value in the first measurement was 5.8 µg / m3 and in the second measurement was 3.8 µg / m3.
Methods:This type of research is descriptive quantitative (Field Research and Laboratory Research). The population is the total number of public transportation and the number of drivers for the Baru-Kota Rayon 02 route, amounting to 154 public transportation units and 154 public transport drivers with the male gender. The samples are some of the public transport drivers for the New Kampus-Kota rayon 02 route.
Results:Nitrogen dioxide (NO2) measurements were obtained96.85 µg / Nm3, 108.79 µg / Nm3 and 100.83 µg / Nm3 for 3 different locations. The highest respiratory complaints were cough symptoms for 47 people and the lowest was shortness of breath as many as 8 people.
Conclusion:Risk management is carried out by reducing exposure time, planting trees that can absorb air pollution, maintaining endurance, limiting the age of motor vehicles and using environmentally friendly fuels.
|
2022-12-28T18:11:33.032Z
|
79,578,090 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4103/TDJ.TDJ_24_17",
"MAG": "2792253080",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Background Rehabilitation of edentulous mandible opposing natural maxillary teeth is associated with many problems. The advent of implants provides a treatment modality that allows the remaining maxillary teeth to be kept. Aim The aim of this study was to evaluate clinically and Radiographically the effect of locator attachment in implant-assisted complete versus single lower overdenture. Materials and methods Twelve patients were selected for this study, half of them were completely edentulous and the other half had edentulous mandible opposing dentulous maxilla. All patients received a lower complete overdenture constructed over two implants, placed at the canine region and retained with locator attachment. Each patient was presented to a questionnaire. The patients were evaluated as regards implant stability, gingival recession, and probing depth. Radiographically, the patients were examined to determine the amount of marginal bone loss. Results The results showed no significant difference in patient satisfaction between the two groups. As regarding the implant stability, gingival recession and probing depth, there was a significant difference of both groups during the follow up period, but the difference was insignificant between both groups at the same follow-up period. Radiographically, there was a significant marginal bone loss during the follow-up period of both groups. In comparing between the two groups, there was an insignificant difference in bone loss between the two groups after 6 months while after 12 months, the difference was signify cant. Locator attachment exhibit high denture stability, better patient satisfaction and accepted clinical parameters and alveolar bone resorption when opposed by dentulous maxilla.
|
2022-02-11T03:51:29.467Z
|
164,847,586 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3906/ZOO-1807-3",
"MAG": "2944050615",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The present study was conducted to elucidate the movement and home range of 7 subadult cinereous vultures Aegypius monachus during the wintering and summering periods using a telemetry system from January 2015 to March 2017 in East Asia. In total, 7053 locations (180?1607 points per bird) were used to analyze the home range size and movement distance of the birds during the wintering, migration, and summering periods. The tracked birds overwintered in South Korea. They migrated between South Korea and Mongolia during spring and autumn, respectively. Their movement and home range size varied considerably throughout the annual cycle between the wintering and summering grounds. The migration route and home range exhibited considerable overlap among the vultures tracked. Further studies on breeding ecology and habitat use pattern are necessary for the conservation of cinereous vultures and their habitats in the wintering and summering grounds.
|
2022-03-27T06:02:01.970Z
|
120,974,818 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.1088/0022-3727/3/1/311",
"MAG": "2047670553",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
It is shown experimentally, using a mercury discharge tube, that the well-documented compression of the gas towards the anode in a low-pressure positive column of uniform cross section can give place to a rarefaction if the cross section is made spatially periodic. This negative pressure gradient has a profound effect on the current-carrying capacity of such columns. A theoretical interpretation of this behaviour is based on the suggestion that, in reflection at the wall sheath in the non-uniform column, the electrons lose, on the average, a proportion of their anode-directed momentum. The periodic column thus provides a case where application of customary assumptions following Langmuir's work leads to new results.
|
2022-09-06T07:13:38.730Z
|
41,656,617 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/ANIE.197200071",
"MAG": "2128584036",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Higher organisms having anatomically and functionally differentiated organ systems must be able to coordinate biochemical processes within and between the various organs or cells, even under rapidly changing environmental conditions. Hormones play an important part in the regulation processes: they promote numerous metabolic reactions and differentiation processes, and show considerable differences in the speed with which they act. Some hormones act almost instantaneously by stimulating adenyl cyclase and thus initiating the production of adenosine 3′,5′-monophosphate (cyclic AMP), which passes on the hormone message (“second messenger”) to the intracellular metabolism by modifying enzyme activities. Delayed-action hormones, mainly morphogenetic hormones, act primarily on the cell nucleus where they induce the synthesis of certain enzymes by activation of genes.
|
2022-09-09T02:49:15.055Z
|
86,701,061 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1210/js.2019-00027",
"MAG": "2916587682",
"PubMedCentral": "6446888"
},
"license": "CCBYNCND",
"status": "GOLD",
"url": "https://academic.oup.com/jes/article-pdf/3/4/763/28269228/js.2019-00027.pdf"
}
|
Abstract The proper clinical evaluation of pituitary and adrenal disorders depends on the accurate measurement of plasma ACTH. The modern two-site sandwich ACTH immunoassay is a great improvement compared with older methods but still has the potential for interferences such as heterophile antibodies and pro-opiomelanocortin (POMC) and ACTH fragments. We report the cases of five patients in whom the diagnosis or differential diagnosis of Cushing syndrome was confounded by erroneously elevated results from the Siemens ACTH Immulite assay [ACTH(Immulite)] that were resolved using the Roche Cobas or Tosoh AIA [ACTH(Cobas) and ACTH(AIA), respectively]. In one case, falsely elevated ACTH(Immulite) results owing to interfering antibodies resulted in several invasive differential diagnostic procedures (including inferior petrosal sinus sampling), MRI, and unnecessary pituitary surgery. ACTH(Cobas) measurements were normal, and further studies excluded the diagnosis of Cushing syndrome. In three cases, either Cushing disease or occult ectopic ACTH were suspected owing to elevated ACTH(Immulite) results. However, adrenal (ACTH-independent) Cushing syndrome was established using ACTH(AIA) or ACTH(Cobas) and proved surgically. In one case, ectopic ACTH was suspected owing to elevated ACTH(Immulite) results; however, the ACTH(Cobas) findings led to the diagnosis of alcohol-induced hypercortisolism that resolved with abstinence. We have concluded that ACTH(Immulite) results can be falsely increased and alternate ACTH assays should be used in the diagnosis or differential diagnosis of clinical disorders of the hypothalamic–pituitary–adrenal axis.
|
2022-10-29T18:40:55.719Z
|
123,642,521 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1103/PHYSREVB.45.11911",
"MAG": "2083213991",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The self-consistent subband electronic structure, potential profile, and charge distribution of a GaAs quantum wire with cylindrical symmetry has been obtained by a numerical solution of the coupled Schrodinger and Poisson equations (within the Hartree approximation). The potential profile is exactly (nearly) parabolic when there are no (few) free carriers inside the wire, but approximates a stretched harmonic oscillator as charge accumulates in the cylindrical quantum wire. The dependence of the results on physical parameters such as the wire radius and concentration of surface states is analyzed
|
2022-12-11T02:05:19.502Z
|
164,987,171 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1210/JS.2019-SUN-016",
"MAG": "2944169880",
"PubMedCentral": "6553081"
},
"license": null,
"status": null,
"url": null
}
|
Abstract 27-Hydroxycholesterol (27-HC) is the most prevalent metabolite of cholesterol in circulation, and also the first identified endogenous selective estrogen receptor (ER) modulator (SERM) (1). Previously, we found that 27-HC acts as an agonist of ER in breast cancer cells, while it acts as an antagonist of ER in endothelial cells in the cardiovasculature. Yet, potential agonistic or antagonistic effects of 27-HC on ER activity in other tissues and cell types remain largely unknown. Here, we examined the effects of 27-HC on ER activity using an ER responsive element (ERE)-luciferase transgenic mice, which have the expression plasmid that contain ERE, linked to a luciferase gene. This mouse model expresses luciferase proteins upon activation of ER, which could be further quantified and visualized by luciferase assay, and imaging respectively. To remove any artifacts from estrogens in the diet and endogenous production at the ovary, the mice were fed an estrogen depleted diet, and female mice were ovariectomized at 8 weeks of age. Both male and female mice were injected subcutaneously with either physiological dose of 27-HC (20 mg/kg body weight), 5ug/kg of 17b-estradiol (E2), E2 plus 27-HC, or vehicle control, at 9am of the day of sacrifice, imaged by in vivo imaging system after treating with luciferin (150mg/kg body weight) intraperitoneally at 3pm, and sacrificed at the same day, at age of 10 weeks. Tissues were collected, homogenized, and measured for luciferase activity through luciferase assay (Promega). The tissue extraction method was also determined to make sure that the luciferase activities are comparable among tissues. The level of ER activity in the presence of E2 was used as a positive control, and upon E2 treatment, ER activity was significantly increased in all analyzed tissues compared to vehicle treatment, with highest levels of ER activity in liver, testis, ovaries, and brain. Interestingly, the 27-HC treatment decreased the ER activity significantly in many tissues both in male and females, suggesting the existence of basal ER activity and an important antagonistic role of 27-HC. Yet, 27-HC showed agonistic effect and the levels of ER activity was even higher than E2 treatments in some tissues, showing a potential important role of 27-HC in these tissues. This study shed light upon potential effects of 27-HC on ER activity in various tissues, that can open the doors for further studies on 27-HC SERM characteristics. Reference:(1) Umetani, Michihisa, et al. Nature medicine 13.10 (2007): 1185.
|
2022-12-16T01:19:01.606Z
|
205,690,480 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/j.1528-1167.2009.02423.x",
"MAG": "1984082922",
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
We have created the Epilepsy Genetic Association Database (epiGAD, http://www.epigad.org, an online database of epilepsy genetic association studies. A systematic search using several search engines identified 165 studies. Herein we analyze the types of studies available, the sample sizes used, and the strength of the findings. Common questions examined were susceptibility to idiopathic generalized epilepsy, focal epilepsy, or febrile seizures, and pharmacogenomic approaches to drug‐resistant epilepsy. Sample sizes were generally small; 80% of studies had 200 or fewer cases, although more recent studies published from 2005–2008 incorporated slightly larger sample sizes. No association was judged as “strong” using current criteria for assessing genetic associations—this is probably due to inadequate sample sizes. Sample sizes need to increase, either by research collaboration or via systematic reviews and meta‐analyses. We believe epiGAD will facilitate future meta‐analyses.
|
2022-12-18T05:10:42.662Z
|
22,401,638 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1074/jbc.M601580200",
"MAG": "2005539763",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The copper chaperone for superoxide dismutase (CCS) is an intracellular metallochaperone required for incorporation of copper into the essential antioxidant enzyme copper/zinc superoxide dismutase (SOD1). Nutritional studies have revealed that the abundance of CCS is inversely proportional to the dietary and tissue copper content. To determine the mechanisms of copper-dependent regulation of CCS, copper incorporation into SOD1 and SOD1 enzymatic activity as well as CCS abundance and half-life were determined after metabolic labeling of CCS-/- fibroblasts transfected with wild-type or mutant CCS. Wild-type CCS restored SOD1 activity in CCS-/- fibroblasts, and the abundance of this chaperone in these cells was inversely proportional to the copper content of the media, indicating that copper-dependent regulation of CCS is entirely post-translational. Although mutational studies demonstrated no role for CCS Domain I in this copper-dependent regulation, similar analysis of the CXC motif in Domain III revealed a critical role for these cysteine residues in mediating copper-dependent turnover of CCS. Further mutational studies revealed that this CXC-dependent copper-mediated turnover of CCS is independent of the mechanisms of delivery of copper to SOD1 including CCS-SOD1 interaction. Taken together these data demonstrate a mechanism determining the abundance of CCS that is competitive with the process of copper delivery to SOD1, revealing a unique post-translational component of intracellular copper homeostasis.
|
2022-12-23T20:58:25.378Z
|
1,364,547 |
{
"externalids": {
"ACL": null,
"ArXiv": "1203.2552",
"DOI": "10.1090/S0894-0347-2013-00775-4",
"MAG": "2593748334",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Let p > 2 be prime. We prove the weight part of Serre’s conjecture for rank two unitary groups for mod p representations in the unramified case (that is, the Buzzard–Diamond–Jarvis conjecture for unitary groups), by proving that any Serre weight which occurs is a predicted weight. Our methods are purely local, using the theory of (φ, Ĝ)-modules to determine the possible reductions of certain two-dimensional crystalline representations.
|
2022-12-22T17:47:19.084Z
|
155,758,057 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1332/204080515X14357650822877",
"MAG": "2210163024",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This study explores the generally prevailing diagnosis of 'hybridization' in the third sector under a new mode of governing welfare, with a focus on processes of devolution of public responsibility and 'responsibilized autonomy' for third sector organizations (TSOs) and volunteers. To this end we conducted semi-structured in-depth interviews with representatives from field-specific umbrella organizations and with officials working in independent governmental agencies. Our analysis generally deals with three themes: devolution of responsibility, accountability, and volunteers as responsibilized service providers. Our findings reveal four paradoxes or unintended consequences of 'responsibilized autonomy': decreased autonomy for TSOs, an administrative deadlock that crowds out grassroots associations and volunteers, an increasing demand for professional support for volunteering, and a bifurcation between strong and weak volunteers, whereby the latter are 're-excluded' through volunteering.
|
2022-12-26T20:02:32.934Z
|
238,055,401 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/14708477.2021.1900214",
"MAG": "3173361674",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
ABSTRACT Attracting the best students into universities is a policy agenda driven by the state and universities in Estonia and Denmark. While the policy of internationalization of higher education (IoHE) in Estonia and Denmark is well crafted in the policy and academic domains, the value additions international graduates add to the learning environments and cultures are hardly explored. This study aims at describing the value added through IoHE in Estonia and Denmark. The study revealed that international graduates bring diversity into the learning environment which promotes teaching, learning and tolerance of other cultures.
|
2022-12-31T18:15:51.346Z
|
138,455,195 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/APP.1982.070271106",
"MAG": "2164840849",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Drawn nylon 6 filaments were subjected to swelling treatment with benzyl alcohol and aqueous solution of phenol and formic acid under slack condition and under tension. The pretreated samples were dyed with a disperse dye Foron Yellow SE-FL (C.I. Disperse Yellow 42). A considerable increase in the equilibrium dye uptake was observed as a result of swelling treatment. Studies on lateral order by X-ray methods showed that lateral order has increased considerably as a result of preswelling treatment. This apparent contradiction, viz., increase in lateral order and at the same time increase in dye upstake, is explained as due to increased void volume. Studies on mechanical properties showed that the percentage elongation is increased as a result of swelling treatment under slack condition in spite of increased lateral order. This is explained as due to the slippage of chain-folded crystallites.
|
2022-02-09T10:07:30.612Z
|
55,144,333 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.17148/IARJSET.2017.4623",
"MAG": "2736809367",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Minerals are essential for human body to regulate the metabolic processes but some elements are also toxic to human body. Seaweeds are taken as food items in different developed and developing countries. So, estimation of minerals composition of seaweeds including the trace metals is important to evaluate food safety. On the other hand, the industrial effluents with pollutant, including toxic heavy metals have adverse effects on the aquatic environment. Different costly conventional treatment technologies are applying for removal of heavy metals from the marine environment. These techniques are economically less beneficial and produce a huge load of toxic chemical sludge on the environment. So, remediation of heavy metals by marine macro algae is a novel eco-friendly alternative approach. The Inductively Coupled Plasma-Optical Emission Spectroscopy (ICP-OES) has been applied to analyse elements such as (Ag, Cu, Co, Ni, Mn, Cr, Pb, Zn, Cd, Al, B, Fe, Mg and Na) of some seaweeds. The two separate standard methods of acid digestion were used to estimate the minerals composition. The aim of study is to evaluate the composition of minerals including heavy metal. From this study, it is concluded that in compare to other seaweeds species, heavy metals are present in high amount in Valoniopsis pachynema, so this species may be used as heavy metals remediator and is not safe to consider as edible. Accordingly, Codium tomentosum and Gracilaria opuntia contain high amount of aluminium, sodium and boron, so these species should also not be consider as edible.
|
2022-02-11T20:14:38.531Z
|
53,978,873 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4236/JSEA.2013.611070",
"MAG": "2089507388",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The Visiting Card Format (VCF) has already been widely used in mobile devices and personal computers (PC). Many mobile manufacturers have developed visiting card recognition systems by using Optical Character Recognition (OCR) technology, which can convert and save the information on the paper cards. However, the inaccuracy of OCR always leads to error in recognition, and it only seizes text information, ignoring images. Our research is to solve that problem based on the vCard format by creating a new VCF, vCardPackage, which contains both textual and pictorial information. It consists of a layout layer, a text content layer, a resource layer and a template layer. The design combines content, layout and images together, and enables users to view or modify mobile devices. The XML storage structure is adopted in the vCardPackage, which is compatible with VCF data, so that the original data can be stored completely when shared or transferred.
|
2022-06-14T08:59:54.643Z
|
252,478,321 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.26689/jcer.v6i9.4314",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": "GOLD",
"url": "http://ojs.bbwpublisher.com/index.php/JCER/article/download/4314/3802"
}
|
The flawed engineering practice is considered the main factor that is affecting to the development quality of engineering postgraduates. Taking Foshan Base as an example, this paper has analyzed the operational pattern, practice teaching model, and internal governance system of the open-ended base as a new system for engineering practice and proposed several suggestions for the reformation of engineering postgraduates based on the construction effect.
|
2022-09-25T17:26:43.436Z
|
6,811,237 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4155/tde-2016-0003",
"MAG": "2339546434",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://www.future-science.com/doi/pdf/10.4155/tde-2016-0003"
}
|
A primary envisioned use for nanoparticles (NPs) in a cellular context is for controlled drug delivery where the full benefit of NP attributes (small size, large drug cargo loading capacity) can improve the pharmacokinetics of the drug cargo. This requires the ability to controllably manipulate the release of the drug cargo from the NP vehicle or 'controlled actuation'. In this review, we highlight new developments in this field from 2013 to 2015. The number and breadth of reports are a testament to the significant advancements made in this field over this time period. We conclude with a perspective of how we envision this field to continue to develop in the years to come.
|
2022-10-25T14:24:19.478Z
|
24,103,993 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1152/AJPGI.1990.258.3.G426",
"MAG": "236280379",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In vitro degradation of 125I-labeled somatostatin-14 (Tyr11) [I-SS-14(Tyr11)] by luminal flushings of rat gastrointestinal segments was studied to characterize the fate of somatostatin in the gastrointestinal lumen. In addition, we evaluated the effect of rat milk as a potential inhibitor of luminal degradation of 125I-SS-14(Tyr11). Degradation of 125I-SS-14(Tyr11) was not detected in stomach flushings from either suckling or weanling rats. Luminal flushings from the small intestine degraded 125I-SS-14(Tyr11), with a gradient increase of activity from duodenum to midjejunum (degradation in suckling rat midjejunum and ileum was about five times lower than that in weanling rat). Degradation of 125I-SS-14(Tyr11) by luminal flushings of suckling rat midjejunum was dose dependently inhibited by rat milk casein and soluble fractions. Inhibitory activity of rat milk soluble fraction was heat labile and several times more potent than that of casein fraction. Casein fraction appeared to be stable at 100 degrees C for up to 30 min of exposure. These studies suggest that somatostatin is stable in the gastric lumen and that milk protects somatostatin from intestinal luminal proteolysis, indicating a possible physiological significance of milk-borne SS-14 for the suckling rat gastrointestinal tract.
|
2022-09-13T07:18:58.871Z
|
199,583,496 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/TVT.2019.2929475",
"MAG": "2963132464",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In the traditional interference channel (IC), each transmitter works in the mode of one-to-one. For serving more user terminals (UTs), a multiple-multicast network is proposed, in which there are multiple transmitters, and each transmitter works in the mode of one-to-many. Thus, each UT would suffer from both the intra-transmitter and inter-transmitter interference. Given the transmitting and receiving degrees of freedom, the desired signal would be more difficult to be separated from the numerous interference signals. For managing the interference, an interference subspace alignment (ISA) algorithm is proposed to decrease the dimension of the interference subspace. Different from the traditional iterative interference alignment (IA) algorithms, which iteratively calculate the precoding and receiving combining matrices to minimize the strength of interference, the ISA algorithm directly aligns the interference subspace spanned by the <inline-formula><tex-math notation="LaTeX">$T-N$</tex-math></inline-formula> transmitters within that spanned by the residual <inline-formula><tex-math notation="LaTeX">$N$</tex-math></inline-formula> transmitters, in which <inline-formula><tex-math notation="LaTeX">$T$</tex-math></inline-formula> denotes the number of all the transmitters, and <inline-formula><tex-math notation="LaTeX">$N$</tex-math></inline-formula> is the cardinality of the transmitter set used for IA. Now, the dimension of each UT's interference subspace is determined via <inline-formula><tex-math notation="LaTeX">$N$</tex-math></inline-formula> transmitters (<inline-formula><tex-math notation="LaTeX">$N < T$</tex-math></inline-formula>). During the subspace alignment, we, respectively, construct the composite IC state matrices for the <inline-formula><tex-math notation="LaTeX">$T-N$</tex-math></inline-formula> and <inline-formula><tex-math notation="LaTeX">$N$</tex-math></inline-formula> transmitters, and the composite precoding vector, which lies in the null space of the composite IC matrices. Thus, all the precoding matrices can be obtained once. After the subspace alignment, each UT's receiving combining matrix can be designed to lie in the null space of the aligned interference subspace. According to the simulation results, the proposed ISA algorithm can effectively suppress the interference and improve the system sum rate compared with the traditional interference management algorithms.
|
2022-12-10T16:36:11.175Z
|
219,732,027 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/1353333021000048950",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
portending catastrophic change in some of the book’s clinical material (such as the case of ‘Mrs A.’). This is perplexing, partly since Ahumada mentions ‘years as an editor and author’ (p.152, italics added), but more significantly because his epilogue explicitly concerns ‘[t]he role of writing and psychoanalytic writings’. Here he espouses the idea that the written text enables us to speak with ourselves, ‘building a psychic space or, in Bion’s terms, an apparatus for thinking thoughts’ (p. 141). (And ‘a gap in the build-up of psychic spaces results from the shift from the culture of text to that of action-in-images’ (ibid.).) However, the empiricist stance ‘distinguishes between words and facts’ and so ‘distances the literary from the psychoanalytic’ (p. 147), so, perhaps, it is as though Ahumada’s empiricist commitment leads him to inhibit his language from coming alive and usurping the place of other, more properly ‘psychoanalytic’, forms of contact with reality. But it seems to me that lifeless language misrepresents life (or represents well only pathologies of lifelessness), and that the comings-into-words of intuition, of the fleetingly conscious, could be warm-blooded and lively without usurping the priority and independence of the experiences of which they are transformations, The Logics of the Mind does succeed in making a space where one can speak to oneself and so think and entertain ‘evolutions’. But the speech has to be that of the (too-absent) editor before it can properly become that of an auditor.
|
2022-12-12T10:18:23.075Z
|
199,543,429 |
{
"externalids": {
"ACL": null,
"ArXiv": "1908.03576",
"DOI": "10.1103/physrevresearch.2.023205",
"MAG": "3008982716",
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "http://link.aps.org/pdf/10.1103/PhysRevResearch.2.023205"
}
|
A 'smoking gun' experiment for the existence of Majorana zero modes in vortices of Fe-based superconductors is the demonstration of error-prone topological quantum computing by moving the vortices around each other infinitely slowly. This kind of braiding, however, poses yet unmet high experimental demands. We introduce a replacing emulation of braiding by only slightly moving vortices within a special spatial arrangement in a finite time. We present analytical results for the braiding gate and highlight their real-world robustness by a realistic tight-binding model for FeTe$_x$Se$_{1-x}$. The results are extended to the (magic) $\pi/8$ phase gate and the CNOT gate resulting in a scalable scheme for finite-time Majorana quantum computing without physically braiding vortices.
|
2022-12-17T15:33:25.303Z
|
119,133,207 |
{
"externalids": {
"ACL": null,
"ArXiv": "1308.4504",
"DOI": "10.1166/jcsmd.2013.1018",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "http://arxiv.org/pdf/1308.4504"
}
|
Abstract. We develop a rigorous formalism for the description of the kinetic evolution of interacting entities modeling systems in mathematical biology within the framework of the evolution of marginal observables. For this purpose we construct the mean field asymptotic behavior of a solution of the Cauchy problem of the dual BBGKY hierarchy (Bogolyubov-Born-Green-Kirkwood-Yvon) for marginal observables of the dynamical systems based on the Markov jump processes, exhibiting the intrinsic properties of the living entities. The constructed scaling limit is governed by the set of recurrence evolution equations, namely by the dual Vlasov-type hierarchy. Moreover, the relationships of the dual Vlasov hierarchy for the limit marginal observables with the Vlasov-type kinetic equation is established.
|
2022-08-29T05:07:22.631Z
|
5,489,167 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1136/bmj.j5523",
"MAG": "2770181860",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Transvaginal mesh should not be used to treat vaginal wall prolapse, because of “serious but well recognised safety concerns,” says draft procedural guidance from the UK National Institute for Health and Care Excellence seen by The BMJ .
The guidance from NICE’s Interventional Procedure Advisory Committee, due to be published on 20 December, concluded that transvaginal mesh repair of anterior or posterior vaginal wall prolapse should be used only in the context of research. NICE said that its guidance had not yet been officially released and was subject to change.
The draft procedural guidance said that data from randomised controlled trials showed no added benefit of using mesh over native tissue repair. It added that when complications occurred these could be serious and have life changing consequences. Evidence of long term effectiveness was inadequate in quality and quantity, it said. Further research was needed, it concluded, which should include details of selection of patients, long term outcomes, including complications, the type of mesh used and method of fixation, and measures of quality …
|
2022-12-11T03:40:26.701Z
|
15,813,898 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1021/JM051119R",
"MAG": "2154896740",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
T-Taxol is a proposal for the bioactive conformation of paclitaxel (PTX) derived from fitting ligand conformations to the electron crystallographic (EC) density. Although confirmed by a number of studies, some structural ambiguities based on the interpretation of two solid-state REDOR (13)C-(19)F distances in a fluorinated PTX derivative remain. An evaluation of the static and dynamic properties of the PTX-tubulin complex shows that small 6-12 degrees variations in calculated torsions and a justifiable increase of the REDOR distance error to > or = +/-0.7 A readily resolves key discrepancies around T-Taxol's service as the bioactive conformation. In addition, conformational analysis reveals a range of (13)C-(19)F separations compatible with the REDOR measurements suggesting that the present PTX REDOR distances may not provide a precise model for bioactive, tubulin-bound bridged taxanes. In addition, we show that New York-Taxol (PTX-NY), a recently proposed alternative to T-Taxol, is incompatible with both the EC density and the activity of a highly active series of bridged taxanes.
|
2022-12-20T03:32:42.297Z
|
246,461,394 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.9734/jpri/2021/v33i60b34894",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": "GOLD",
"url": "https://doi.org/10.9734/jpri/2021/v33i60b34894"
}
|
The superficial surface of the body called as skin has its main function as tactile reception, on stimulation of the emotional background there might be a presence of certain type of psychosomatic reactions that tend to cause dermatological changes, this in turn brings about the vast nature of psychodermatology.
Background: Several report study and research have revealed that psychological stress has a huge role in the progression or worsening of a wide range of skin conditions.
Aim: To determine if psychological stress has any role to play in onset or progression of skin related diseases or disorders
Methodology: We conducted a systemic search of the related topics on pubmed, google scholar, Medline and some manual searches were done for the relevant studies and accordingly the articles were selected and reviewed.
Results: As per many researches and studies that were conducted, some prevalent skin disorders caused due to psychological stresses are: dermatitis artefacta, skin hypochondriasis, acne, eczema, psoriasis.
Conclusion: Psychological stress has been linked to the worsening of certain skin conditions. However, due to the difficulties of identifying and quantify Psychologicccal stress, along with issues about the etiologic importance of neuroimmunological findings in skin illnesses, this condition become more worsened.
|
2022-12-23T02:05:38.655Z
|
11,785,366 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/1469-8986.00116",
"MAG": "2119749606",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "https://europepmc.org/articles/pmc1413574?pdf=render"
}
|
Distinct event-related potential effects have been related to familiarity and recollection processes underlying recognition memory. Familiarity has been conceptualized as similar either to perceptual priming mechanisms supporting implicit memory or to amodal global-matching processes that should show little sensitivity to perceptual variables. The present experiment manipulated the study modality of words (auditory, visual) that were visually tested for recognition memory. The mid-frontal (300-500 ms) old/new effect often attributed to familiarity was not affected by study modality, so it appears related to an amodal familiarity process. An earlier (176-260 ms) fronto-polar old/new effect was perceptually specific in that it was observed only following visual study. The parietal old/new effect (400-800 ms), often attributed to recollection, was similar following both visual and auditory study. Temporal-spatial PCA clarified the separability of these effects.
|
2023-01-01T16:17:09.532Z
|
200,119,305 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.21125/EDULEARN.2019.0365",
"MAG": "2964182608",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Simulation involves participating in a very real learning experience that closely resembles an actual setting. This presentation will delineate what we know and do not know about the use of simulations in teacher preparation programs. Based on a literature review, the advantages and disadvantages will be shared with the audience. While simulated environments are not a replacement for field experiences, they do offer several advantages to perhaps better prepare preservice teachers and can be possibly be used to argument field experiences. Simulations have been found to have distinct advantages, such as increasing understanding; providing a format for skill building; and developing critical thinking and cultural skills (Clapper, 2010). Virtual classrooms can also offer an environment for experiencing various student characteristics and learning about teaching approaches not easily observable in real classrooms. Foley and McAllister (2015) reported that the complex diversity of the simulated environment in terms of racial, cultural, and language needs of virtual students was a useful context for candidates to become more aware of issues, to understand students’ unique characteristics, and to plan for differentiated strategies. There are also limitations of simulations including that simulated environments usually only represent a small group of students and not a full classroom; the lessons learned and knowledge gained may not transfer to real world classroom; and the work in the simulated environment may not increase candidate’s confidence in actual classrooms. The purpose of this session is to review how simulated learning experiences have been used to enhance or replace traditional field experiences in preservice teacher education programs and to discuss the benefits and limitations of these experiences. Participations will learn about classroom simulations, how they are currently used in teacher preparation programs, and the advantages and disadvantages of their usage. Based on the presentation, participants can make informed decisions about the use of classroom simulations in teacher preparation programs.
|
2022-01-19T20:45:02.954Z
|
227,137,607 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3760/CMA.J.ISSN.1005-054X.2008.06.005",
"MAG": "3030819501",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Objective To investigate changes in gene expression of nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) after acute peripheral nerve injury in rats.Methods Forty-eight SD rats were randomly divided into 8 groups.Right sciatic nerve injury model was established by transection and direct repair in rats of 7 groups.Another group of unoperated rats served as normal control.One cm of sciatic nerve segment centered at the repair site was harvested at postoperative day 1,2,3,4,5,6 and 7 respectively.Total RNA was extracted and expression of NGF mRNA and BDNF mRNA was quantified using reverse transcriptase-polymerase chain reaction (RT-PCR).Results NGF mRNA and BDNF mRNA could be detected in normal rat sciatic nerves at a relatively low level.Obvious increase of NGF mRNA expression was seen first day after sciatic nerve injury,which maintained at a higher level there after.BDNF mRNA rose to a higher than normal level 4 days after nerve injury.At postoperative day 5 and day 6 it dropped to nomal.At postoperative day 7 BDNF mRNA increased again.Conclusion Changes of NGF and BDNF expression are not synchronized after rat sciatic nerve injury.This indicated that different factors are involved in regulating NGF and BDNF mRNA content in acute peripheral nerve injury.
Key words:
Peripheral nerves; NGF; BDNF; mRNA
|
2022-02-07T23:38:39.376Z
|
153,903,523 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1386/NCIN.6.2.145_4",
"MAG": "2036151842",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Film festival report, raising wider questions of political commitment in contemporary cinema
|
2022-02-09T02:07:03.046Z
|
21,392,909 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/MC.2011.27",
"MAG": "2041908578",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
As we look to the future, we must not only anticipate a year of innovation and progress but also a migration of labor that will remake the field of digital technology.
|
2022-02-12T21:08:11.335Z
|
16,581,416 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.17487/RFC7064",
"MAG": "2267951270",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This document specifies the syntax and semantics of the Uniform
Resource Identifier (URI) scheme for the Session Traversal Utilities
for NAT (STUN) protocol.
|
2022-06-04T14:34:00.467Z
|
96,097,650 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/POL.1977.180150803",
"MAG": "1993472566",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Raman depolarization (ρ) measurements have been made over the temperature range 20 > T > 60°C for solutions of poly(dimethyl siloxane) (mol wt 7.7 × 104 and 2.0 × 104) for several concentrations up to 100%. The band studied was the highly polarized methyl stretch at 2907 cm−1. Computer calculations of the probability pt of a rotational isomer being trans allow the ρ values to be related to ΔG, the free energy of mixing. ΔG is plotted as a function of concentration and minima are observed at 60 ± 3% (mol wt = 7.7 × 104) and 70 ± 3% (mol wt = 2 × 104).
|
2022-07-08T10:49:28.340Z
|
104,918,278 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.30638/EEMJ.2016.288",
"MAG": "2886756051",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A new simple empirical model is proposed to describe the waste sludge volumetric flow rate in the steady-state completely mixed activated sludge process. The model is derived based on the nonlinear regression analysis by using the Richardson’s extrapolation method and the Levenberg–Marquardt algorithm. The application of the model has been explored for a wide range of eleven fundamental biological design variables and tested against a total of 1500 additional computational scenarios and real wastewater plant data. All predictions are proven to be satisfactory with very high determination coefficients of about 0.97 and 0.99, respectively, for the forecast of waste sludge flow rate. Compared with the theoretical approach, the proposed model offers a quite simple and practical mathematical structure incorporating easily obtainable parameters, which are routinely ascertained in the activated sludge-based treatment plants. Besides obviating the need for time-consuming theoretical procedure, the developed equation facilitates the calculations and can be used for any distinct cases of waste sludge withdrawal. Computational results demonstrate that the proposed equation is accurate enough to be used in estimation of waste sludge production and sufficiently simple to be used with a hand-held calculator.
|
2022-09-02T00:17:46.073Z
|
4,439,150 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1177/0272989X16654692",
"MAG": "2469491786",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Background. Physicians’ recommendations affect patients’ treatment choices. However, most research relies on physicians’ or patients’ retrospective reports of recommendations, which offer a limited perspective and have limitations such as recall bias. Objective. To develop a reliable and valid method to measure the strength of physician recommendations using direct observation of clinical encounters. Methods. Clinical encounters (n = 257) were recorded as part of a larger study of prostate cancer decision making. We used an iterative process to create the 5-point Physician Recommendation Coding System (PhyReCS). To determine reliability, research assistants double-coded 50 transcripts. To establish content validity, we used 1-way analyses of variance to determine whether relative treatment recommendation scores differed as a function of which treatment patients received. To establish concurrent validity, we examined whether patients’ perceived treatment recommendations matched our coded recommendations. Results. The PhyReCS was highly reliable (Krippendorf’s alpha = 0.89, 95% CI [0.86, 0.91]). The average relative treatment recommendation score for each treatment was higher for individuals who received that particular treatment. For example, the average relative surgery recommendation score was higher for individuals who received surgery versus radiation (mean difference = 0.98, SE = 0.18, P < 0.001) or active surveillance (mean difference = 1.10, SE = 0.14, P < 0.001). Patients’ perceived recommendations matched coded recommendations 81% of the time. Conclusion. The PhyReCS is a reliable and valid way to capture the strength of physician recommendations. We believe that the PhyReCS would be helpful for other researchers who wish to study physician recommendations, an important part of patient decision making.
|
2022-02-13T11:48:48.369Z
|
97,666,399 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/KIN.550090204",
"MAG": "2952995457",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The reactions have been studied by a mass-balance method involving the photolysis of small amounts of biacetyl in the presence of a large excess of isobutane containing a small proportion of the unsaturated substrate. The following Arrhenius parameters have been derived: Text
Table Text. Temperature
E log A range
Reaction (kcal/mol) (1./mol·sec) (°K)
ĊH3 + C2H4 Ċ3H7 7.3 ± 1.0 8.32 ± 0.5 350 – 500
ĊH3 + C2H2 Ċ3H5 7.7 ± 1.5 8.79 ± 0.8 379 – 487
ĊH3 + C6H6 C7H9 7.6 ± 1.0 8.79 ± 0.5 372 – 484
The results for methyl addition to ethylene are based on previous determinations by other techniques as well as the present studies. The results for methyl addition to acetylene and benzene are derived solely from the present experiments and are calculated relative to a rate constant of log k2(l./mol·sec) = 7.42 - (7.1/θ) for the reference reaction (2), ·H3 + (CH3)3CH CH4 + ·4H9.
|
2022-12-11T03:01:18.331Z
|
21,554,959 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/EPTC.2012.6507094",
"MAG": "1995823728",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
As companies realize that alternatives to 3D TSV die stacks are needed for commercial products, many companies are moving into production with embedded components in IC package substrates. The use of embedded die enables the production of a thin package that meets critical requirements of mobile products. Embedded components are found in many different configurations. Package-on-package is one of the latest package types to make use of embedded components. Some companies will embed active components in the substrate using a lamination process while others have adopted different manufacturing methods. Embedded actives are just one example of production packages, and there are applications that also use embedded formed resistors or capacitors, while others embed discrete passive components. This presentation examines the drivers for today's embedded component applications and how today's developments differ from technology introduced in the past.
|
2022-02-12T21:01:19.663Z
|
202,961,754 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.21744/ijllc.v5n5.727",
"MAG": "2971144433",
"PubMedCentral": null
},
"license": "CCBYNCND",
"status": "GOLD",
"url": "https://sloap.org/journals/index.php/ijllc/article/download/727/1221"
}
|
One of the important points within the evaluation is who performs it, long ago it was understood that the evaluation always came from an external instance to the evaluation, which was usually the teacher. Self-assessment is when the student is evaluated, while co-evaluation is when the group evaluates in a reciprocal way, encouraging participation, critical and constructive reflection, identifying achievements and shortcomings within the process of Learning. This article aimed to identify the application of self-assessment and co-evaluation in learning processes, where the research was of exploratory type, the scientific method was applied, synthetic analytical, gave as end result that teachers know the importance of these evaluative practices, because of situations of conformity, monotony, and fear of causing enmities with students do not use them.
|
2022-03-07T02:56:31.131Z
|
245,429,543 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.54103/2464-8914/16888",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "https://riviste.unimi.it/index.php/irlh/article/download/16888/14851"
}
|
The documents conserved in the Terracini Jewish Archive of Turin allow the reader to examine the application of the legislation concerning Jewish communities during the period of time starting from the Napoleonic domination until the Italian unity. My research focuses in particular on the notarial deeds and judicial documents relating to the property of the synagogue and the cemetery of the Jewish community of Mondovì. Under the rule of France the Jewish people living in Piedmont were allowed to become real estate owners and the plots of land where the Jewish cemetery was located and the house that hosted the synagogue in Mondovì were allotted to the Jewish community. During the Restoration, the ban to become real estate property was introduced again. Even if the Jewish people of Mondovì had bought from its owner the house of the synagogue and they had obtained from the French administration the property of the plots of land of the cemetery, they were not anymore recognized as owners. After the emancipation of the Jewish population and the Italian unity, the Jewish community of Mondovì claimed its rights on those real estate properties: my essay would focus on the exam of the archive documents that show how the legislation concerning real estate property for Jewish people was applied over time.
|
2022-05-27T00:14:24.146Z
|
233,193,300 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5863/1551-6776-26.3.271",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8021249"
}
|
OBJECTIVE
To evaluate the safety of the combination of methadone and an atypical antipsychotic in PICU patients.
METHODS
This was a retrospective observational cohort pilot study in a single-center PICU in an academic children's hospital. Children 1 month to 18 years of age were included if they received methadone, were then initiated on an atypical antipsychotic (i.e., quetiapine or risperidone), and had EKG monitoring before and after medication initiation.
RESULTS
Prolongation of the corrected QT (QTc) interval occurred in 5 of the 34 included patients when an atypical antipsychotic was added to methadone. Of the 5 patients who had a prolonged QTc interval, 4 (80%) were older than 12 years and had a median weight of 91.3 kg. There were statistical differences between age and weight when comparing patients who experienced QTc prolongation, but no differences in sex, ethnicity, electrolyte deficiencies, number of additional QTc-prolonging medications, and number of additional drug-drug interactions were identified. When comparing atypical antipsychotics, 9.5% of patients receiving risperidone had a prolonged QTc interval, versus 23% of patients receiving quetiapine (p = 0.04). The net change in QTc interval after initiation of methadone was 0.19 milliseconds (IQR: -3, 15), which increased after atypical antipsychotic initiation to 4 milliseconds (IQR: -16, 15).
CONCLUSIONS
Our pilot trial suggests there is no clinically significant difference in incidence of QTc prolongation with addition of atypical antipsychotics to methadone.
|
2022-06-25T07:20:11.163Z
|
198,183,994 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2991/ICSKSE-18.2019.8",
"MAG": "2953664997",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Local custom-based forest management conducted by Bayan community is one way of forest preservation. Local custom-based management is always guided by awiq awiq local wisdom. Awiq awiq is a customary law that is obligatory for Bayan people to obey. This law regulates the relationship between humans and other humans, nature, and God. A customary law regulating the relationship between humans and the nature is represented in the rules of forest management within Bayan community. This study aims to find out the perception of Bayan community towards the awiq awiq local wisdombased forest management. It is a qualitative study using in-depth interview as the method of data collection. The traditional leaders became the key informants while the supporting informants consisted of the head of Sub-District, Head on Bayan Village, and Bayan indigenous people. The data analysis was conducted in four stages, namely reduction, categorization, synthesis, and conclusion. The results show that the community has a positive perception towards awiq awiq in forest management. The community is still employing this law in their effort to maintain and conserve the forest sustainability.
|
2022-10-19T15:05:53.652Z
|
220,886,644 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/access.2020.3010788",
"MAG": "3043984676",
"PubMedCentral": null
},
"license": "CCBYNCND",
"status": "GOLD",
"url": "https://ieeexplore.ieee.org/ielx7/6287639/8948470/09145749.pdf"
}
|
For electronic nose systems to obtain meaningful information from sensor data, sensor response features are first extracted for further signal processing. However, redundant features may diminish the accuracy of gas classification. To solve this problem, a minimum distance inlier probability (MDIP) feature selection (FS) method is proposed. By incorporating the intrinsic properties of features and ranking strategy, MDIP can efficiently eliminate redundant features and provide better classification accuracy. The performance of the method was validated on two open-access datasets that provide information for system variation and sensor drift problems, respectively. Experimental results revealed that the average classification accuracy for the two datasets was higher by 46.1% and 37.5%, respectively, with the MDIP method.
|
2022-10-28T01:14:22.953Z
|
86,635,052 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.15517/RBT.V55I2.6027",
"MAG": "2090985191",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Se estudiaron los contenidos estomacales de 88 zooides de Ecteinascidia turbinata Herdman 1880 y la composicion cualitativa y cuantitativa del fitoplancton en la columna de agua en Santa Fe (Litoral Norte de la Habana) y Punta del Este (SW de Cuba). En el contenido estomacal de la ascidia se identificaron 59 especies de microalgas y cuatro tintinidos. El tamano de las celulas vario entre 75 y 165 μm de largo y de 2 a 105 μm de ancho. No se encontraron diferencias significativas en la diversidad de especies de microalgas en la columna de agua de las dos localidades. Las diatomeas tuvieron la mayor cantidad de especies y el mayor numero de individuos, tanto en los estomagos como en la columna de agua en ambas localidades. La biomasa de dinoflagelados en Santa Fe fue mayor en agua y estomagos. En Punta del Este el aporte de cada grupo al contenido estomacal es similar al encontrado en la columna de agua. Esta especie filtra de forma constante e irregular durante las 24 horas del dia, independientemente de la disponibilidad de alimento.
|
2022-02-10T22:16:15.763Z
|
146,610,994 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2118/195358-MS",
"MAG": "2938677321",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Alaska North Slope (ANS) contains heavy oil (12-23 API) with an estimated range of original oil in place (OOIP) of 13 to 25 billion barrels. This resource has been considered as one of the largest heavy oil deposits in the United States. However, several technical challenges are limiting its commercial development. One of the most significant difficulty is the overlying 1,800-2,000 ft-thick permafrost layer, which causes unavoidable significant heat losses when steam is injected from the surface steam generators, and the potentially disastrous effects due to melting of the permafrost around the cemented casing. Therefore, surface steam injection might not be a viable option to develop this resource, although it is the most commonly used approach of heavy-oil recovery. Hence, the objective of this research is to conduct a feasibility study on the application of new approach, in which steam is generated downhole using thermochemical reaction (SGT) combined with steam assisted gravity drainage (SAGD), to recover heavy oil from Ugnu reservoir which is one of the major oil deposits in ANS.
A numerical simulation model for Ugnu heavy oil reservoir is built using CMG-STARS simulator. Then a MATLAB framework is integrated with the simulation model to study different recovery strategies on the project profitability. Net Present Value (NPV) is used in this study as the key performance indicator while monitoring oil recovery factor (RF) and cumulative oil production (COP). The design and operational parameters studied and optimized in this paper involve; 1) well configurations and locations, 2) steam injection rate and quality, steam trap and startup heating period to initialize SAGD process.
The results show that the in-situ SGT is a successful approach to recover heavy oil from Ugnu reservoir and it yields high project profitability, in terms of the NPV after 10 years of development. The main reason of this outperformance is ability of SGT to avoid the significant heat losses and associated costs, in the surface steam injection methods.
This paper introduces a novel approach to generate downhole steam using thermochemical reactions to overcome the challenges associated with heavy-oil resource development from Ugnu reservoir, while minimizing the environmental impact by reducing the greenhouse gas emission related to surface steam injection methods.
|
2022-03-02T14:21:55.997Z
|
145,098,609 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1353/BOC.1989.0009",
"MAG": "2089251877",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This study considers the relations between socially mobile prostitutes and decadent aristocrats as dramatized in Cervantes' entremés. The problem springs from the evolution from a traditional land based economy to one where wealth was a function of money, and the consequent realization that the traditional social signifiers of class and status could be counterfeited by money. A law of 1611 had attempted to codify society visually, to put everyone in his/her place by a new system of visual signifiers that would provide reliable data. The action of the play is set immediately following promulgation of the new law, and reveals its effects on two sets of characters who represent its two target groups: prostitutes and aristocrats. The behavior of both groups should be altered, but in practice only the prostitutes are forced to reform. The play's anti-aristocratic social message is encoded in a set of binary oppositions: up-down; in-out; riding-walking; coach-foot; coachhorse that stand for society's divisions. The study elucidates these semiotic relationships and locates them in historical context, especially with relation to the social values present in the signifier vizcaíno. (CBJ)
|
2022-08-29T06:51:12.425Z
|
220,062,248 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/08946566.2020.1782300",
"MAG": "3037217567",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
ABSTRACT Elder abuse is a pervasive public health issue. The relationship between personality traits and elder abuse remains unclear. This study aims to examine the associations between neuroticism, conscientiousness, and elder abuse. Data were derived from the Population Study of Chinese Elderly (PINE), a community-engaged study of 3,157 US Chinese older adults in the greater Chicago area from 2011–2013. Elder abuse included psychological, physical, and sexual abuse, financial exploitation, and caregiver neglect. The assessments of neuroticism and conscientiousness were derived from the NEO Five-Factor Inventory. Logistic regression was used. Higher neuroticism (score range: 6–30, OR = 1.14, CI = 1.11–1.18) and lower conscientiousness (score range: 16–60, OR = 0.97, CI = 0.96–0.99) were associated with a higher risk of elder abuse. With respect to different forms of elder abuse, higher neuroticism was associated with an increased risk of psychological abuse (OR = 1.14, CI = 1.10–1.17), financial exploitation (OR = 1.03, CI = 1.00–1.07), and caregiver neglect (OR = 1.06, CI = 1.03–1.09). Higher conscientiousness was associated with a higher risk of financial exploitation (OR = 1.02, CI = 1.00–1.05). Intervention programs could reduce neuroticism and raise conscientiousness of elder abuse victims.
|
2022-09-07T01:55:27.371Z
|
32,090,044 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/j.1755-3768.1978.tb03808.x",
"MAG": "1972968219",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Of 46 patients consecutively admitted to hospital for ocular contusion with hyphaema in 1964 and 1965, 30 patients were followed‐up somewhat more than 10 years later in order to assess late complications. Angle‐recession was observed in 17 (57%), while none had developed glaucoma. An average increase in depth of the anterior chamber of 0.06 mm in the affected eye was observed; this differences is highly significant with P < 0.005. However, as these changes are small in individual patients, measurement of the increase in anterior chamber depth can only be a supplement to gonioscopy.
|
2022-12-11T23:29:42.044Z
|
24,909,782 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/AR.A.20097",
"MAG": "1973728189",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Following liver transplantation, all hepatic nerves are transected; thus, liver allografts are completely isolated from neural control of their hosts. Despite this absolute denervation, liver allograft function does not appear to be significantly impaired after successful transplantation. In experimental animal models, hepatic denervation has no major effects on bile acid production and biotransformation, while it increases blood pressure and salt retention; decreases the number of hepatic progenitor cells, cholangiocyte proliferation, and liver regeneration; and influences the hepatic microcirculation, diet behavior, and glycemic control. In humans, hepatic denervation after liver transplantation has no major deleterious effects on bile secretion, liver regeneration, and hepatic blood flow. Insulin resistance and postprandial hyperglycemia, changes in ingestion behavior, and reduced stimulation of hepatic progenitor cells in the canals of Hering are the major side effects of absent liver innervation. Despite these abnormalities, patients can lead a new life with improved quality of life.
|
2022-12-24T14:40:25.903Z
|
18,397,885 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1093/NAR/GKF457",
"MAG": "2046244086",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The 5'-leader sequence (called Omega) of tobacco mosaic virus (TMV) functions as a translational enhancer in plants. A poly(CAA) region within Omega is responsible for the translation enhancement and serves as a binding site for the heat shock protein, HSP101, which is required for the translational enhancement. Genetic analysis of the HSP101-mediated enhancement of translation from Omega-containing mRNA suggested that two eukaryotic initiation factors (eIFs), i.e. eIF4G and eIF3, were necessary. In this study, the functional interaction between Omega and other RNA elements known to participate in the recruitment of eIF4G, i.e. the 5'-cap and the poly(A) tail, was examined. Omega exhibited functional overlap with the 5'-cap and the poly(A) tail but not with the native TMV 3'-UTR which contains an independent translational enhancer. Consistent with the role of HSP101 in mediating the translational function of Omega, the enhancement afforded by Omega increased following a heat shock, which elevates expression of HSP101. The use of a fractionated translation lysate revealed that of the two eIF4F proteins present in plants, eIF4F was specifically required for the activity of Omega. The data suggest that Omega is functionally similar to a 5'-cap and a poly(A) tail in that it serves to recruit eIF4F in order to enhance translation from an mRNA.
|
2022-12-26T15:40:16.475Z
|
244,019,388 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.31219/osf.io/uwkd6",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "https://osf.io/uwkd6/download"
}
|
There are significant factors affecting the decisions about supplier selection for procurement in steel construction firms: parts prices and transportation costs, payment periods, parts lengths and considering penalty terms coming from firm’s clients. Therefore, in order to select optimal firms, each proposal must be considered on equal terms. As a result, ‘Net Present Value’ should be calculated in evaluating payment period, lead time, parts lengths and also transportation costs payment period. This evaluation may bring about decrease in costs of parts based on older procurements. For an optimal solution, a mathematical model which includes, demand of units, net present value of products, delay cost due to retardation of Project is required. Moreover, the possibility of making predictions for future scenarios may assist in mapping out a route for the decision makers in steel construction firms. On this account, this study is designed to develop a mathematical model for the supplier selection system using integer programming.
|
2022-01-27T04:19:01.490Z
|
229,519,493 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.26456/vtphilos/2020.3.197",
"MAG": "3108681793",
"PubMedCentral": null
},
"license": null,
"status": "GOLD",
"url": "http://eprints.tversu.ru/10111/1/%D0%92%D0%B5%D1%81%D1%82%D0%BD%D0%B8%D0%BA%20%D0%A4%D0%B8%D0%BB%D0%BE%D1%81%D0%BE%D1%84%D0%B8%D1%8F%202020%20%E2%84%96%203-197-211.pdf"
}
|
В статье ставится цель проведения сравнительного анализа мистериально-теургических учений символистов (Д.С. Мережковский, Андрей Белый, Александр Блок, Вяч. Иванов, Павел Флоренский), направленных на духовное преображение сущности мира и человека на основе конкретного и религиозного усилия по преодолению сдерживающих и тормозящих внутреннее совершенствование начал. Творческие начала мира призваны активизировать эстетический и морально-нравственный потенциал, заложенный в человечестве.
The goal of the article is to conduct a comparaitive analysis of the mystery-theurgical teachings of the Symbolists (D.S. Merezhkovsky, Andrey Beliy, Aleksandr Blok, Vach. Ivanov, P. Florensky), aimed at spiritual transformation of the essence of the world and of man on the basis of a concrete and religious effort to overcome the principles that restrain and hinder internal improvement. The creative principles of the world, used by them, are designed to activate the aesthetic and moral-ethical potential inherent in humanity.
|
2022-01-27T06:17:02.499Z
|
72,136,039 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1136/BMJ.39392.813160.BE",
"MAG": "2049086168",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
William Stewart Ogden was known to his friends, colleagues, and patients as Bill Ogden. Bill went up to Jesus College, Cambridge, in 1948 to read natural sciences, where he was able to pursue his passions for medicine, rowing, rugby, and jazz. Bill started his medical career in ear, nose, and throat surgery at St Bartholomew's Hospital, …
|
2022-02-11T10:13:26.214Z
|
237,246,170 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/AEMCSE51986.2021.00280",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In recent years, more and more attention has been paid to the safe and stable operation of electrified railway, especially to the vehicle-network coupling stability, which focuses on the phenomena of high frequency resonance (HFR) and low frequency oscillation (LFO), which has become the research hotspot. Firstly, this paper studies the impedance model of the traction network and the train power system, and proposes the AF-RCS impedance model of the vehicle-network. Based on this model, from the perspective of grid-side converter control strategy, AOC inhibition measures are proposed to solve the instability of vehicle-network coupling caused by insufficient system damping. Furthermore, VCT inhibition measures were proposed to quickly reduce the damage of HFR to the system. Finally, the VCT-AOC comprehensive suppression strategy was proposed, which improved the damping ratio and enhanced the stability of the system while rapidly protecting the system. The effectiveness of the method is verified by simulation and experiment.
|
2022-01-24T17:28:35.368Z
|
41,567,163 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/LMAG.2011.2180704",
"MAG": "2072388594",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Magnetostatically interacting structures consisting of 1.5 μm diameter rings of radially oriented nanomagnets were investigated using magnetic force microscopy. An even number of nanomagnets, 16 in this case, formed a ground state in which the magnetizations of neighboring nanomagnets were oriented antiparallel. However, an odd number of nanomagnets, 15, led to a frustrated state in which at least one pair of neighboring nanomagnets was magnetized parallel, giving a net radial magnetic charge. The “defect” in the structure was moved around the ring by a modest external field.
|
2022-03-04T03:11:49.524Z
|
64,336,660 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2991/ICENCE-16.2016.73",
"MAG": "2521657006",
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},
"license": null,
"status": null,
"url": null
}
|
This study aims to research the applicability of the WOFOST model and predict winter wheat yield on a regional scale. The automatic information in study area could be achieved from the wireless sensor network (WSN) deployed in cropland. The observed results including the phenological dates, LAI and the yield are compared with the simulated results in WOFOST. It is found that the maximum deviation of observed and simulated days taken to anthesis is seven days, and the maximum deviation of observed and simulated days taken to maturity is five days. The simulated days to anthesis and days to maturity indicate that WOFOST model underestimates the phenological period of wheat in both years. Through the analysis of LAI, it can be seen that simulated results are agree well with the observed results, except the early stage of growth. The phenomenon can be attributed to the simulated growth period is earlier than the actual test. Moreover, the observed mean yields are 5410 and 5536 kg ha during 2006-2007 and 2007-2008, respectively. The simulated mean yields are 5936 and 6027 kg ha during 2006-2007 and 2007-2008, respectively. Based on the relative root mean square error, the modified WOFOST model presented a very good to fair estimation of wheat yields. The results of this study provide an important theoretical reference for WOFOST model monitoring and estimating winter wheat growth status on a regional scale. It indicates that WOFOST model is a useful tool in yield forecasting.
|
2022-04-26T16:08:17.439Z
|
249,030,470 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.7764/cdi.52.37535",
"MAG": null,
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},
"license": "CCBYSA",
"status": "GOLD",
"url": "http://cuadernos.info/index.php/cdi/article/download/37535/40377"
}
|
Ante la problemática que supone la escasa presencia de las mujeres como fuentes en noticias sobre política en los medios, este estudio observó cuál es el tipo de tratamiento periodístico que se le da a la información política cuando su voz es femenina. Para ello, se analizó el contenido de cuatro periódicos que circulan en la capital de Chile y de dos medios regionales durante 2007, 2011 y 2015, con el fin de estudiar la cantidad de fuentes de ambos sexos presentes en la información política, la cantidad de espacio asignada, el tipo de fuente de las que se trataba, y si la prensa utiliza a hombres y mujeres de manera diferenciada al enmarcar las noticias con algunos de los cinco encuadres noticiosos propuestos por Semetko y Valkenburg (2000). Mediante este análisis, se constató que de las 2569 fuente analizadas las mujeres figuran como fuentes en el 16,8%. Se puede observar que, en general, el periodismo no trata a los hombres y a las mujeres que trabajan en política de manera similar, salvo en el caso de la extensión de las citas. A la luz de los resultados, se plantea la necesidad promover un periodismo más consciente y dispuesto a reducir estas brechas por medio de la visibilidad y la normalización de la participación de la mujer en cargos políticos de alta relevancia, considerados hasta hace pocos años como espacios masculinos.
|
2022-05-27T01:00:29.627Z
|
21,037,183 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/CESYS.2016.7889910",
"MAG": "2600316132",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Aimed at the very nonlinear and vulnerability of differing cost of building changes, another technique for differing cost of building destruction in view of Enhanced Particle Swarm Optimization (EPSO) back propagation has been proposed. By presenting transformation operation and versatile modify of dormancy weight, the issue of simple to fall into neighborhood ideal, untimely, low exactness and low later interation effectiveness of Particle Swarm Optimization are comprehended. By utilizing the Enhanced Particle Swarm Optimization to streamline Back Propagation neural network's parameters, the learning rate and optimization capacity of traditional Back Propagation are adequately moved forward. At that point the versatile molecule swarm optimization calculation taking into account cloud hypothesis was utilized to improve the weights and edges of wavelet Back propagation neural network, Instead of customary inclination drop strategy. The reproduction aftereffects of differing cost of building expectation demonstrate that the anticipate exactness of the new strategy is altogether higher than that of ordinary Back Propagation neural network and wavelet neural network technique. What's more, the technique is viable and attainable.
|
2022-12-12T22:53:06.890Z
|
164,781,499 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/hyp.13478",
"MAG": "2944718328",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Planning soil conservation strategies requires predictive techniques at event scale because a large percentage of soil loss over a long‐time period is due to relatively few large storms. Considering runoff is expected to improve soil loss predictions and allows relation of the process‐oriented approach with the empirical one, furthermore, the effects of detachment and transport on soil erosion processes can be distinguished by a runoff component. In this paper, the empirical model USLE‐MB (USLE‐M based), including a rainfall‐runoff erosivity factor in which the event rainfall erosivity index EI30 of the Universal Soil Loss Equation (USLE) multiplies the runoff coefficient QR raised to an exponent b1 > 1 is tested by the measurements carried out for the Masse (10 plots) and Sparacia (22 plots) experimental stations in Italy. For the Masse experimental station, an exponent b1 > 1 was also estimated by tests carried out by a nozzle‐type rainfall simulator. For each experimental site in fallow conditions, the effect of the sample size of the plot soil loss measurements on the estimate of the b1 coefficient was also studied by the extraction of a fixed number N of randomly obtained pairs of the normalized soil loss and runoff coefficient. The analysis showed that the variability of b1 with N is low and that 350 pairs are sufficient to obtain a stable estimate of b1. A total of 1,262 soil loss data were used to parameterize the model both locally and considering the two sites simultaneously. The b1 exponent varied between the two sites (1.298–1.520), but using a common exponent (1.386) was possible. Using a common b1 exponent for the two experimental areas increases the practical interest for the model and allows the estimation of a baseline component of the soil erodibility factor, which is representative of the at‐site soil intrinsic and quasi‐static properties. Development of a single USLE‐MB model appears possible, and sampling other sites is advisable to develop a single USLE‐MB model for general use.
|
2022-12-17T16:56:25.560Z
|
123,147,594 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1017/S0022112088003106",
"MAG": "2097800434",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A simple phenomenological drag relation is used to characterize weak dynamic coupling of a liquid membrane to an adjacent solid substrate. With this linear velocity-dependent drag relation, the inertialess equations of motion for membrane flow are easily solved for steady translation and rotation of a disk-like particle. The resulting drag coefficients exhibit functional dependencies on the dimensionless particle size very similar to the relations obtained for particle motion in a membrane bounded by semi-infinite liquid domains (Hughes et al. 1981), although the scaling of particle size is different. Within this phenomenological approach, diffusivities of molecular probes in membranes can be used to investigate the intrinsic molecular drag at a solid-liquid membrane interface and to estimate properties of thin lubricating liquid layers between membrane and substrate.
|
2022-12-19T13:44:16.234Z
|
201,814,473 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/ICMA.2019.8816197",
"MAG": "2970234076",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This paper presents an improved SURF algorithm based on gradient and amplitude pre-computation. This method is based on the traditional SURF algorithm and replaces the complex Gauss calculation with integral graph search. There are extreme value features and high frequency noise describing the edge and sharpness of the image. In order to measure the relationship between them, it is necessary to introduce the signal-to-noise ratio measurement index to highlight the effective features or their components. When constructing Hessian matrix with SURF algorithm, Hessian algorithm is sensitive to gradient change. It can describe the gradient of image well. The method of calculating gradient magnitude before Hessian can effectively improve the effect of existing SURF algorithm. This method solves the problem of small number of feature points and non-uniform feature points in traditional SURF algorithm. It has the advantages of high accuracy of feature points extraction and better noise suppression. It can be introduced into underwater three-dimensional reconstruction, which can effectively improve the accuracy and quality of underwater target three-dimensional reconstruction and provide strong support for underwater observation and operation of underwater vehicles.
|
2022-01-27T01:49:24.953Z
|
224,797,911 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1086/447929",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Most of us become acquainted with something called poetry in our early childhood. We meet it as a Mother Goose rhyme, a jingle to remember the months by, a counting-off rhyme, sing-song to be recited while playing certain games, or as the words of a song. We are told that all these are "poems," and we soon learn to recognize other "poems" on our own, through their also being in verse and rhyme. At first we tend to be pleased with almost any verses, so long as the rhythm is emphatic or sprightly enough; later we become more discriminating and begin to think of some poems as good, others as bad; later still we begin to consider the subject of the poem or its diction or something more than the mere verse, and to be pleased or displeased by these as well. Our conception of poetry alters accordingly so that we are not too greatly surprised when we are told, at some point in our education, that there is a distinction between poetry and verse, that, indeed, verse is not essential to a poem. Presently we are told about the special forms of poetry, such as ballad and epic and lyric, as well as about the "nature" of poetry itself; and "laws and rules" of its composition, the criteria by which it is to be judged; and most of us accept these assertions without bothering to puzzle over them, much less question them. Even if we do notice discrepancies among definitions or rules or criteria we are not too much troubled; by now we have unconsciously dismissed certain aspects of poetry as matters of mere taste or opinion, and so tend to be pleased with discrepant statements as reflecting interesting variations in taste and opinion. By now, too, we have read and even studied a good many
|
2022-01-27T05:39:36.813Z
|
122,208,027 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/TMAG.1975.1058754",
"MAG": "2128817586",
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},
"license": null,
"status": null,
"url": null
}
|
The amplitudes of the signal lobes ("Bessel Maxima") observed in several types of thin film SQUIDs excited at 9.2 GHz exhibit pronounced periodic intensity modulation. This behavior is consistent with the simplified flux entry model proposed by Mercereau in the limit of \tau \sim T where T is the shortest time between successive flux entry into loop and τ is the flux passage time. From our results, τ was deduced to be \sim 10^{12} seconds for both proximity effect and narrow constriction devices.
|
2022-07-23T19:21:32.706Z
|
135,698,794 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4028/www.scientific.net/AMR.332-334.1856",
"MAG": "2008337241",
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},
"license": null,
"status": null,
"url": null
}
|
Microencapsulated n-octadecane (MicroC18) and doped with thermochromatic powders (TC-MicroC18) were prepared with melamine-formaldehyde (M-F) resin as the wall via in-situ polymerization. The chemical structure and thermal behavior of microcapsules were investigated using fourier transform infrared spectroscopy (FTIR), and differential scanning calorimetry (DSC). Experimental results show that 63 wt% n-C18 has been incorporated into microcapsules, and the obvious thermochromatic effect of TC-MicroC18 is displayed with temperature changing. The structure-properties of TC-MicroC18 also is discussed in detail from the aspect of molecular structure.
|
2022-09-07T05:02:17.746Z
|
230,574,317 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.7150/ijms.50680",
"MAG": "3111287774",
"PubMedCentral": "7797546"
},
"license": "CCBYNC",
"status": "GOLD",
"url": "https://www.medsci.org/v18p0604.pdf"
}
|
Chronic psychological stress affects many body systems, including the skeleton, through various mechanisms. This review aims to provide an overview of the factors mediating the relationship between psychological stress and bone health. These factors can be divided into physiological and behavioural changes induced by psychological stress. The physiological factors involve endocrinological changes, such as increased glucocorticoids, prolactin, leptin and parathyroid hormone levels and reduced gonadal hormones. Low-grade inflammation and hyperactivation of the sympathetic nervous system during psychological stress are also physiological changes detrimental to bone health. The behavioural changes during mental stress, such as altered dietary pattern, cigarette smoking, alcoholism and physical inactivity, also threaten the skeletal system. Psychological stress may be partly responsible for epigenetic regulation of skeletal development. It may also mediate the relationship between socioeconomic status and bone health. However, more direct evidence is required to prove these hypotheses. In conclusion, chronic psychological stress should be recognised as a risk factor of osteoporosis and stress-coping methods should be incorporated as part of the comprehensive osteoporosis-preventing strategy.
|
2022-12-07T21:36:50.447Z
|