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255M
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86,250,604 |
{
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"ArXiv": null,
"DOI": "10.1002/JCCS.200700080",
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|
Tumor cells transduced with herpes simplex virus thymidine kinase gene have been intensively applied to the field of positron emission tomography via imaging of its substrate. As a pilot synthesis approach, a facile preparation of 5-[ 125 1]iodoarabinosyl uridine starting from commercially available uridine is reported herein.
|
2022-09-14T17:53:19.709Z
|
249,256,768 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1093/sleep/zsac079.092",
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"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://academic.oup.com/sleep/article-pdf/45/Supplement_1/A42/43842363/zsac079.092.pdf"
}
|
The importance of human cortical theta-band power during REM is suggested by its association with aspects of emotional processing. Currently, this is measured first by visual-inspection of polysomnography to define REM-sleep (scored-REM) and then summing the total theta power within. However, activity attributed to scored-REM has been hypothesized to occur during some scored-NREM (“covert REM”) and total theta conflates different theta-band sources. Oscillatory theta-band activity (OTA) in the hippocampus and associated regions is the hallmark of REM-like sleep in invasive animal studies. We posit that an EEG assessment specifically targeting all-night OTA is a more accurate biomarker of theta-dependent REM functions than current methods. As a first step towards testing this hypothesis, we developed a sleep stage independent approach to isolate REM-like OTA from scalp-EEG. For validation, we compared this measure to conventional-staging and high-frequency activity.
Our method uses Irregular-Resampling Auto-Spectral Analysis to remove the aperiodic spectrum (a major source of theta-band power), followed by low-band power normalization to derive the relative oscillatory-theta activity (OTA). Covert REM-containing epochs were calculated based on OTA exceeding a threshold. We combined data from two in-laboratory studies resulting in a sample size of 42 healthy young adult subjects. Analyses used non-sleep restricted overnight EEG recordings from a frontal channel.
A clear oscillatory-theta peak was observed after processing. Using all sleep stages, we found separation of OTA from total theta-band power evidenced by conventional staging (OTA: scored-REM>scored-NREM, p=0.003 vs total theta: scored-REM<scored-NREM, p<0.001) and correlation with beta-band activity (OTA: r=0.2, p<0.001 vs total theta: p=0.4). Supporting “covert REM”, OTA was present during scored-NREM (p<0.001). On average during a single sleep episode, covert REM was found in 28% of scored- NREM epochs (range=2-85%).
We developed a novel automated method for measuring REM-like oscillatory-theta activity, independent of conventional sleep staging methods. This method was used to measure REM-like activity across all sleep stages and, as reported in a companion abstract, test the hypothesis that this constitutes a better predictor of REM-dependent behavioral effects than current conventions.
This effort was fully supported by the Department of Defense Military Operational Medicine Research Program (MOMRP).
|
2022-11-25T00:46:27.426Z
|
108,893,784 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/IEDM.1974.188793",
"MAG": "1994070065",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Summary form only given, as follows. The speed and packing density of circuits can be increased by the use of small devices such as FETs. !n analyzing a circuit that incorporates small FET devices, the engineer needs to describe the inherent short-channel effects. Also, the greater speed and packing density increase the need for accuracy in the statistical descriptions of both devices and circuits. In this work a model to describe short-channel effects, as well as process-induced device statistics and temperature effects, is given. The model includes an expression for the current of an IGFET, taking into account the dependence of mobility on the electric field; appropriate corrections are made for channel doping and temperature. To describe the saturation current, an approximation to a quasi-two-dimensional Poisson solution is applied to the pinch-off region. The saturation current-voltage characteristic is matched to that of the triode, with continuity maintained in the first derivative. By using the charge control approach and accounting for the gate charge and the channel charge, the gate-source and gate-drain capacitances that exist with the device on are derived as a function of the gate-source and gate-drain potentials. The gatesubstrate capacitance is introduced with the device off. The expressions in the model are given in terms of the thickness and charge of the gate oxide; the length, width, and doping of the channel; and a variety of geometrical factors for calculating the overlap capacitance. By using this model with ASTAP, computations for statistical analysis can be made readily by introducing variations in relevant parameters.
|
2022-02-10T06:43:44.039Z
|
207,558,948 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1172/JCI117064",
"MAG": "1988454200",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Pancreatic beta-cell function was studied in six subjects with mutations in the enzyme glucokinase (GCK) who were found to have elevated fasting and postprandial glucose levels in comparison to six normoglycemic controls. Insulin secretion rates (ISRs) were estimated by deconvolution of peripheral C-peptide values using a two-compartment model and individual C-peptide kinetics obtained after bolus intravenous injections of biosynthetic human C-peptide. First-phase insulin secretory responses to intravenous glucose and insulin secretion rates over a 24-h period on a weight maintenance diet were not different in subjects with GCK mutations and controls. However, the dose-response curve relating glucose and ISR obtained during graded intravenous glucose infusions was shifted to the right in the subjects with GCK mutations and average ISRs over a glucose range between 5 and 9 mM were 61% lower than those in controls. In the controls, the beta cell was most sensitive to an increase in glucose at concentrations between 5.5 and 6.0 mM, whereas in the patients with GCK mutations the point of maximal responsiveness was increased to between 6.5 and 7.5 mM. Even mutations that resulted in mild impairment of in vitro enzyme activity were associated with a > 50% reduction in ISR. The responsiveness of the beta cell to glucose was increased by 45% in the subjects with mutations after a 42-h intravenous glucose infusion at a rate of 4-6 mg/kg per min. During oscillatory glucose infusion with a period of 144 min, profiles from the subjects with mutations revealed reduced spectral power at 144 min for glucose and ISR compared with controls, indicating decreased ability to entrain the beta cell with exogenous glucose. In conclusion, subjects with mutations in GCK demonstrate decreased responsiveness of the beta cell to glucose manifest by a shift in the glucose ISR dose-response curve to the right and reduced ability to entrain the ultradian oscillations of insulin secretion with exogenous glucose. These results support a key role for the enzyme GCK in determining the in vivo glucose/ISR dose-response relationships and define the alterations in beta-cell responsiveness that occur in subjects with GCK mutations.
|
2022-12-20T13:44:18.790Z
|
39,568,428 |
{
"externalids": {
"ACL": null,
"ArXiv": "1403.6751",
"DOI": "10.1088/0004-637X/797/2/92",
"MAG": "2129435656",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The low-mass X-ray binary (LMXB) Cen X-4 is the brightest and closest (<1.2 kpc) quiescent neutron star transient. Previous 0.5–10 keV X-ray observations of Cen X-4 in quiescence identified two spectral components: soft thermal emission from the neutron star atmosphere and a hard power-law tail of unknown origin. We report here on a simultaneous observation of Cen X-4 with NuSTAR (3–79 keV) and XMM-Newton (0.3–10 keV) in 2013 January, providing the first sensitive hard X-ray spectrum of a quiescent neutron star transient. The 0.3–79 keV luminosity was erg s−1, with ≃60% in the thermal component. We clearly detect a cutoff of the hard spectral tail above 10 keV, the first time such a feature has been detected in this source class. We show that thermal Comptonization and synchrotron shock origins for the hard X-ray emission are ruled out on physical grounds. However, the hard X-ray spectrum is well fit by a thermal bremsstrahlung model with kTe = 18 keV, which can be understood as arising either in a hot layer above the neutron star atmosphere or in a radiatively inefficient accretion flow. The power-law cutoff energy may be set by the degree of Compton cooling of the bremsstrahlung electrons by thermal seed photons from the neutron star surface. Lower thermal luminosities should lead to higher (possibly undetectable) cutoff energies. We compare Cen X-4's behavior with PSR J1023+0038, IGR J18245−2452, and XSS J12270−4859, which have shown transitions between LMXB and radio pulsar modes at a similar X-ray luminosity.
|
2022-12-25T21:52:00.407Z
|
86,106,606 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.7744/CNUJAS.2011.38.2.249",
"MAG": "2202714014",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This study was performed to investigate the characterization of infectious BLV env gene isolated form Korean Holstein Cattle and to determine its incoming origin. Gp51 region of BLV env gene known as having important role in immunological function was characterized using PCR-RFLP sequencing and phylogenetic analysis. BLV env gene was grouped into PCR-RFLP patterns with three restriction endonucleases including Pvu Ⅱ, BamHI and HaeⅢ, and we identified two new RFLP patterns from nucleotide sequences of each group. Phylogenetic analysis showed that 80% of the Korean Holstein was included in the USA and Japanese group. These results here can provide a valuable information about the character of the BLV env gene and research on infection route of BLV.
|
2022-03-06T09:01:33.102Z
|
109,403,344 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.13031/2013.32068",
"MAG": "2014110090",
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},
"license": null,
"status": null,
"url": null
}
|
A device, consisting of a jar fitted with an inlet comprised of a gas-tight check valve and two-way ball valve outlet connected via tubing to a portable peristaltic pump, was constructed to collect water samples without atmospheric contamination or loss of dissolved gases. A headspace void for dissolved gas analysis was created by enclosing silicone tubing sealed with rubber stoppers within the jar. The device was deployed in a 0.4-ha lagoon that served as the primary waste recipient of a 2,000-sow farrowing operation as well as a 4,000-ha impoundment reservoir. Water samples were analyzed for dissolved methane and common indices of water quality such as pH, suspended solids, various ions, and metals concentration. In addition, lagoon wastewater samples were analyzed for malodorous compounds. For reservoir samples, methane concentrations at the bottom of the lake of 60 µg L-1 were about three orders of magnitude higher than at the upper levels of the lake while ammonium levels increased from 0.03 mg L-1 at the surface to 1.67 mg L-1 in bottom samples. pH steadily decreased from 8.58 near the surface to 7.47 at the bottom. Other water quality parameters such as dissolved metals were similar at each depth. For lagoon samples, ammonium concentration and malodorous compounds declined markedly as temperatures warmed. Results for both reservoir and lagoon sampling indicate that this device affords an inexpensive yet effective means of water collection for subsequent analysis of both water quality and dissolved gas concentration.
|
2022-09-09T11:12:39.667Z
|
45,488,203 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3390/APP7090929",
"MAG": "2754071796",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The Internet of Things (IoTs) relies on efficient node memories to process data among sensors, cloud and RF front-end. Both mainstream and emerging memories have been developed to achieve this energy efficiency target. Spin transfer torque magnetic tunnel junction (STT-MTJ)-based nonvolatile memory (NVM) has demonstrated great performance in terms of zero standby power, switching power efficiency, infinite endurance and high density. However, it still has a big performance gap; e.g., high dynamic write energy, large latency, yield and reliability. Recently, voltage-controlled magnetic anisotropy (VCMA) has been introduced to achieve improved energy-delay efficiency and robust non-volatile writing control with an electric field or a switching voltage. VCMA-MTJ-based MRAM could be a promising candidate in IoT node memory for high-performance, ultra-low power consumption targets.
|
2022-12-02T11:28:07.912Z
|
35,821,184 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3290/j.jad.a32569",
"MAG": "2414415335",
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},
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"status": null,
"url": null
}
|
PURPOSE
To test the hypothesis that the number of adhesive layers influences the adhesive interface properties under cariogenic challenge conditions using a Streptococcus mutans model.
MATERIALS AND METHODS
Bovine teeth (n = 90) were sectioned into blocks of 5 mm and divided into two groups for microleakage testing (n = 60) and tensile bond strength testing (n = 30). In each group, the samples were subdivided into subgroups according to the number of adhesive layers applied on the dentin: one (SB1), two (SB2), and three adhesive layers (SB3). The samples of the control groups were placed in BHI broth medium supplemented with 2% sucrose without microorganisms, and the experimental groups were submitted to Streptococcus mutans American Type Culture Collection (ATCC) for 5 days. For the tensile strength test, samples were sectioned into 1-mm-thick slices and submitted to a constant load of 0.5 mm/min in a universal testing machine. Fractured surfaces were analyzed and characterized as adhesive, cohesive, or mixed. The microleakage test was performed with silver nitrate solution.
RESULTS
In experimental groups, the tensile test revealed a statistically significant difference between the one- (18.59 ± 5.3) and three-layer (11.28 ± 5.0) groups (p < 0.001; ANOVA and Tukey's test). The adhesive failure mode was slightly more frequent in the one- (60%) and three-layer (80%) adhesive application groups. On the other hand, the microleakage levels of all experimental groups were statistically similar (Kruskal-Wallis; p > 0.05).
CONCLUSION
The experimental conditions influenced tensile properties and failure modes of different adhesive interfaces; however, they did not influence microleakage.
|
2022-11-24T18:36:31.142Z
|
83,798,325 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1556/CRC.36.2008.SUPPL.B.16",
"MAG": "1984316130",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Wheat Fusarium head blight (FHB) may cause serious losses in grain yield and quality in China. More than 7 million hectares which approximately accounts for 25% of the total areas in China is infected by the disease. The cultivation of wheat varieties with resistance to Fusarium head blight is recognized as one of the most important components to diminish losses due to this disease. Chinese wheat breeders have commenced the research on FHB since 1950s. Wheat cultivars with improved FHB resistance were developed through conventional breeding. Some famous resistant varieties such as Sumai 3, Yangmai 158 and Ning 7840 were released from Jiangsu Academy of Agricultural Sciences, these varieties were widely applied in wheat production and breeding programs. Significant achievements concerning molecular mapping and marker assisted selection have been made in the past decade. The major QTL on chromosome 3BS was identified and located in the same region on chromosome 3BS in Sumai 3, Ning 894037, Wangshuibai, and Chinese Spring. Using SSR marker in this QTL region for assisted selection, some lines with the same resistance to FHB were obtained. New STS markers and SSCP markers were developed and will be tested for the efficiency of MAS. However, further achievements are still hindered by a number of constraints. More FHB resistance genetic resources from landrace in middle to lower reaches of Yangtze River are necessary to be used for improving FHB resistant. The genetic mechanism of the varieties contributing the resistance to improved cultivars is needed to be understood. Development of functional markers for FHB is discussed.
|
2022-09-14T18:28:17.745Z
|
7,568,491 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/10615806.2010.481792",
"MAG": "2029897127",
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},
"license": null,
"status": null,
"url": null
}
|
Abstract Taking care of offspring during a prolonged period of time is probably one of the most stressful life experiences for parents. The present study compares the cortisol awakening response (CAR) in 38 long-term caregivers (mothers and fathers of schizophrenic relatives) with a control group of 32 non-caregivers. Factors such as general stress, caregiver burden, patient severity, and institutionalization were studied. Although a blunted CAR was observed in caregivers in comparison with controls, this difference was not significant. Among caregivers, the absence of institutionalization for the patient is associated with a lack of CAR in caregivers in comparison with caregivers of institutionally supported patients. General stress, caregiver burden, and patient severity themselves did not favor significant changes in CAR. CAR shows greater sensitivity to institutional support than patient severity and perceived stress. Further research is needed to explain the impact of these factors on health and the psychological factors involved.
|
2022-12-12T05:07:40.837Z
|
207,973,329 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/ISGT-LA.2019.8895020",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This paper presents an impact analysis of distributed generation high insertion in a microgrid connected to an electric power distribution system, focusing on the short-circuit levels. The study is conducted considering four distributed generator technologies: DFIG, photovoltaic generator, synchronous generator, and induction generator. The investigation was carried out by applying solid three-phase faults in different system buses and considering different scenarios of generators connection, allowing to evaluate the increase of network short-circuit levels due to the individual and collective operation of the distributed generators. The influence of the generators in voltage sags in the system is also analyzed. Simulations were carried out in Simulink® software using a distribution system based on a real feeder. Only the grid-connected mode of the microgrid was considered. The results allowed to evaluate key factors related to the different contributions of each type of distributed generator in the system short-circuit levels and the possible impacts caused by the massive insertion of such technologies.
|
2022-12-19T03:46:20.357Z
|
8,239,465 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4172/2329-891X.1000146",
"MAG": "2144617703",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Schistosomiasis, a debilitating disease dating back to ancient times, is currently endemic in 78 tropical and subtropical countries with 243 million people requiring treatment. Current treatment of schistosomiasis depends primarily on a single drug, praziquantel which is less effective against larval stage of the parasite and has potential for development of resistance. Thus, there is urgent need for development of new, effective and inexpensive antischistosomal drugs. Simple naphthoquinone (NAPQ) secondary metabolites in plants are known to act as phytotoxins in preventing bacterial, fungal and parasitic attacks. The present study reports antischistosomal activity of nineteen plant-derived and synthetic simple NAPQs and naphthols against Schistosoma mansoni adult worms under in vitro conditions. Four of the tested compounds met the WHO’s Special Program for Research and Training in Tropical Diseases (TDR) in vitro criterion for “hit” and lead compound (100% mortality of adult worms at a concentration of ≤ 5 µg/ml when incubated for 48 h): plant-derived naphthazarin, two synthetic NAPQs, 1, 4-NAPQ and 2-methy-1, 4-NAPQ (menadione) and synthetic 1-amino-2-naphthol hydrochloride. Structure-antischistosomal activity studies with 1, 4-NAPQs indicated the importance of the number and position of hydroxyl and methyl groups, particularly at C-2, C-5 and C-8 positions of the parent NAPQ molecule, which play important role in stabilizing quinone moiety and formation of reactive oxygen species essential for antiparasitic effect. The results call for further in vivo studies on the chemopreventive potential of plant-derived naphthazarin and synthetic 1,4-NAPQ, menadione and 1-amino-2-naphthol, all of which have met the WHO/TDR in vitro criterion for their consideration as lead schistosomicidal candidates.
|
2022-12-18T15:30:06.869Z
|
234,075,643 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1039/d0ra07800j",
"MAG": "3126404239",
"PubMedCentral": "9133880"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://pubs.rsc.org/en/content/articlepdf/2021/ra/d0ra07800j"
}
|
Conducting polymers are extensively studied due to their outstanding properties, including tunable electrical property, optical and high mechanical properties, easy synthesis and effortless fabrication and high environmental stability over conventional inorganic materials. Although conducting polymers have a lot of limitations in their pristine form, hybridization with other materials overcomes these limitations. The synergetic effects of conducting polymer composites give them wide applications in electrical, electronics and optoelectronic fields. An in-depth analysis of composites of conducting polymers with carbonaceous materials, metal oxides, transition metals and transition metal dichalcogenides etc. is used to study them effectively. Here in this review we seek to describe the transport models which help to explain the conduction mechanism, relevant synthesis approaches, and physical properties, including electrical, optical and mechanical properties. Recent developments in their applications in the fields of energy storage, photocatalysis, anti-corrosion coatings, biomedical applications and sensing applications are also explained. Structural properties play an important role in the performance of the composites.
|
2022-12-29T16:24:27.769Z
|
155,345,042 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2202/2161-2412.1049",
"MAG": "2313056152",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "https://scholarsarchive.byu.edu/cgi/viewcontent.cgi?article=3096&context=facpub"
}
|
Teachers were recruited from the mainland of the United States to work in rural areas in the State of Hawaii to meet the high demand for personnel. But often there is a mismatch between the culture of the island residents and that of the new teachers. To alleviate this mismatch, a workshop was developed to promote multicultural proficiency of school personnel focusing on Asian/Pacific cultures. One hundred teachers, administrators and staff (including custodians and cafeteria workers) from four rural elementary schools participated in a three hour workshop. The workshop consisted of three activities: (a) self-awareness, (b) awareness of Asian/Pacific Island cultures, and (c) instructional strategies and resources to support culturally diverse students. A mixed repeated measures design was used to make comparisons between the workshop participants responses on pre/post administrations of the Multicultural Assessment of Proficiency (MAP) scale, a questionnaire designed and developed to measure the effects of the workshop. Results indicated that all participants improved significantly and that three factors accounted for the majority of the variance: knowledge of strategies and resources, awareness of self/others (beliefs), and willingness to take future action. Limitations, suggestions for future research, and implications for practice are discussed.
|
2022-12-30T00:16:46.050Z
|
95,570,120 |
{
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"ACL": null,
"ArXiv": null,
"DOI": "10.1590/S0100-06832002000100019",
"MAG": "2036145977",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Seeds of common bean (Phaseolus vulgaris L.) with high P concentration, obtained from plants which had received foliar fertilization, were used in a greenhouse experiment to evaluate the effects of seed P concentration on growth and nodulation of common bean during the vegetative stage.The experiment had a 2x2x 3x3 factorial randomized block design with four replicates: two cultivars (Carioca and Rio Tibagi), two seed P concentrations (low and high, corresponding to 4.3 and 5.6mgg-1 for Carioca, and 4.8 and 6.3mgg-1 for Rio Tibagi), three levels of P applied to the soil (0, 30 and 60mgkg-1, respectively, P0, P30 and P60) and three times of harvesting (20, 30 and 40days after emergence - DAE).The high seed P concentration increased the dry matter of bean plants at P0 at the three harvests, and at P30 at 40DAE.Plants originating from high P seeds showed a lower dependence of soil P supply, in regard to dry matter production, than those originating from low P seeds.The high seed P concentration increased the number of nodules in Carioca at P0 by 20 and 30DAE, and increased nodule mass at P30 by 20DAE in both cultivars, and by 40DAE at P30 in Carioca and at P60 in Rio Tibagi.The accumulation of N by shoots at 20DAE was greater in plants originating from high P seeds.The results demonstrate that seeds with high P concentration obtained by foliar fertilization can enhance growth, nodulation and N accumulation of bean plants at early growth stages, particularly at low P levels applied to the soil.
|
2022-12-30T01:17:38.948Z
|
170,848,405 |
{
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"ArXiv": null,
"DOI": "10.5380/AVS.V20I3.38527",
"MAG": "2301651216",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Com o objetivo de se avaliar a influencia da concentracao serica de IgG no ganho de peso de bezerras em fase de aleitamento e apos um ano de vida, 45 bezerras Holandesas foram distribuidas em tres baias coletivas com alimentadores automaticos e submetidas a tres protocolos de aleitamento (Tratamentos experimentais) denominados de 4L, que teve o fornecimento de quatro litros diarios de sucedâneo lacteo; 6L, com seis litros; e AL, com fornecimento ad libitum. As bezerras entraram no experimento com cinco dias de idade e concentracao de IgG que variou entre 13,4 e 43,7 mg/dL. O peso foi aferido semanalmente. Apos o desmame todas as bezerras foram manejadas sob as mesmas condicoes ate um ano de vida. Nessa fase, a mensuracao do peso corporal foi feita mensalmente. Utilizou-se o delineamento inteiramente casualizado, correlacao linear de Pearson, analise de variância ANOVA e testes de Tukey, e t pareado a 5%. Nao houve influencia da IgG no ganho de peso ao desmame e tambem apos um ano, entre os tratamentos e desconsiderando-se os tratamentos. Quanto aos protocolos de aleitamento, os tratamentos 6L e AL foram superiores no ganho de peso ao desmame, enquanto 4L e ALforam superiores apos um ano.
|
2022-04-08T00:18:59.668Z
|
95,444,714 |
{
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"ArXiv": null,
"DOI": "10.1557/PROC-353-1405",
"MAG": "2002568665",
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},
"license": null,
"status": null,
"url": null
}
|
Curium-doped perovskite slurry, which had the nominal composition of Ca{sub 0.98919}(CM,Pu){sub 0.01081}Al{sub 0.01081}Ti{sub 0.98919}O{sub 3}, was calcined at 750 C for 2 h and then hot-pressed at 1,250 C and 29MPa for 2 h. The hot-pressed cylinder samples had the specific {sup 244}Cm activity of 22.3 GBq/g on 31 March 1993. Their average density was 4.083 g/cm{sup 3} after the samples got a cumulative dose of 0.7 {times} 10{sup 17} {alpha} decays/g. The rate of density change was slightly larger in the present perovskite material than in Cm-doped Synroc reported previously. Half-disk perovskite specimens, which had accumulated doses of 1.6 {times} 10{sup 17} and 4.0 {times} 10{sup 17} {alpha} decays/g, were MCC-1 leach tested in pH {approximately}2 solution at 90 C and 2.3 g/m{sup 2}/day, respectively. These high leach rates caused a significant increase in pH in the later stage of the leaching runs. As-leached surfaces of Cm-doped perovskite showed the formation of anatase (TiO{sub 2}). For the first 28 days, the Ca and Cm leach rates at the two different doses increased with leach time. More damaged specimens tended to give higher leach rates. In the final 28-day leaching run, both leach rates at the two different doses convergedmore » on each lower value although the Cm leach rate was lower than the Ca leach rate by a factor of >20. Nonradioactive perovskite material showed similar changes in Ca leach rate and pH to the Cm-doped one although the as-leached surfaces of the former material showed much higher degree of alteration of perovskite to anatase.« less
|
2022-09-04T01:49:01.291Z
|
137,239,117 |
{
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"ArXiv": null,
"DOI": "10.1063/1.1594552",
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},
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"status": null,
"url": null
}
|
Three compositionally identical Pu-bearing reference glasses were prepared in July 1982, each containing 1 wt.% PuO2; however, the 238Pu/239Pu isotopic ratio was different in each glass. As a result, the a-activities in the as-prepared glasses varied by nearly a factor of 200. The actual activities measured are within 15% of the intended values. In the 20 some years since their preparation, several studies have been performed on these glasses. The final results of the most recent studies are summarized in this paper.
|
2022-09-05T08:13:50.231Z
|
167,875,074 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2139/ssrn.1618730",
"MAG": "2286971079",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This paper examines the effects of competing measures of earnings surprises on the value of insurance firms for a sample of 105 Life-Health insurers and 109 Property-Casualty insurers during the 1998-2007 period. Using the surprise portfolio approach, we find that investors in insurance stocks react to "street earnings" rather than accounting earnings and there is a positive relation between the magnitude and direction of earnings surprises and cumulative abnormal returns. Our results support the differential information hypothesis in the context of insurance industry. The evidence shows that smaller size insurers, those with higher information asymmetry and those followed by fewer analysts convey more information to market participants, generating higher cumulative abnormal returns in response to earnings surprises.
|
2022-12-09T11:53:58.600Z
|
85,226,846 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3101/1098-7096(2006)66[118:SIGOPF]2.0.CO;2",
"MAG": "2055888127",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
ABSTRACT We conducted dose-response studies of the toxicity of salicylate (SA; a putative signal molecule for enhancement of plant disease resistance [EPDR]) toward plant-pathogenic fungi. SA concentrations ≥10.0 mM were required for complete inhibition of fungal growth from mycelial plugs. SA doses of 2.0–5.0 mM typically reduced fungal growth by 50%, whereas doses of 0.5 mM or lower had little or no effect on fungal growth. However, growth of several test fungi was completely inhibited by 2.0 mM SA combined with concentrations of cupric chloride, antifungal bacterial culture fluids, or neem extract that were otherwise only slightly to moderately inhibitory. We conclude that (1) endogenous SA concentrations (up to 10.0–100.0 μM) are unlikely to directly inhibit fungi in plants, (2) concentrations of exogenous SA applied for EPDR (2.0–10.0 mM) are likely to be only moderately inhibitory to fungi, and (3) additions of other antifungal materials with which SA synergizes may enhance the antifungal activity of SA applied to plant surfaces for EPDR. The latter conclusion provides a rationale for further study of the synergistic interactions of moderately active antifungal materials for practical plant disease control.
|
2022-12-18T03:11:26.686Z
|
84,373,249 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4167/JBV.2015.45.1.54",
"MAG": "2026452917",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Tobacco rattle virus (TRV) is a plant pathogen belonging to the Group IV positive-sense single-stranded RNA viruses. TRV causes disease in various plants (e.g., potato, tomato and tobacco), for which it was classified as a controlled quarantine virus in Korea. This study aimed to develop specific primer sets for the rapid detection of TRV. Two RT-PCR primer sets were developed for specific detection of TRV. Furthermore, nested primer sets were also developed, which is required for high sensitivity detection in plant quarantine. The RT-PCR and nested PCR products had the following sizes: set 5 (1,096→540 bp), and set 7 (878→756 bp), respectively. In addition, a modified positive-control plasmid was also developed for use as a positive control in TRV quarantine. The diagnostic system for TRV detection was verified using samples from Korean quarantine sites for the last five years (2009-2014). A total of 83 cases were detected among various import crops. This system for detection of TRV will continuously contribute to plant quarantine in the future.
|
2022-12-18T06:51:35.274Z
|
6,015,428 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/TVT.2014.2329696",
"MAG": "2034415518",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Leveraging the development of mobile communication technologies and increased capabilities of mobile devices, mobile multimedia services have set new trends. To support high-quality Video-on-Demand (VoD) in mobile wireless networks, using virtual community-based approaches to balance the efficiency of content sharing and maintenance cost of performance-aware solutions has attracted increasing research interest. In this paper, we propose a novel Performance-aware Mobile Community-based VoD streaming solution over vehicular ad hoc networks (PMCV). PMCV relies on a newly designed mobile community detection scheme and an innovative community member management mechanism. The former employs a novel fuzzy ant-inspired clustering algorithm and an innovative mobility similarity estimation model to group together the mobile users with similar behavior in terms of playback and movement into mobile communities. The latter introduces the role and task of members, member join and leave, collaborative store and search for resources, and replacement of a broker member. Simulation-based testing shows how PMCV outperforms another state-of-the-art solution in terms of performance.
|
2022-12-27T20:24:29.363Z
|
129,850,098 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3997/2214-4609.201411964",
"MAG": "2029206603",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
em, decisions have been made by Petrobras to relocate various well placements. During the process we have taken the issues and incorporated them into a new revision of the system which shall also be explained, comparing the current “Next Generation” OptoSeis design to that which was installed on the Jubarte field. While the design changes are subtle they will lead to a more cost effective and reliable system in the future.
|
2022-02-09T14:31:09.961Z
|
250,108,270 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3390/su14137781",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.mdpi.com/2071-1050/14/13/7781/pdf?version=1656234048"
}
|
In order to explore the application of robots in intelligent supply-chain and digital logistics, and to achieve efficient operation, energy conservation, and emission reduction in the field of warehousing and sorting, we conducted research in the field of unmanned sorting and automated warehousing. Under the guidance of the theory of sustainable development, the ESG (Environmental Social Governance) goals in the social aspect are realized through digital technology in the storage field. In the picking process of warehousing, efficient and accurate cargo identification is the premise to ensure the accuracy and timeliness of intelligent robot operation. According to the driving and grasping methods of different robot arms, the image recognition model of arbitrarily shaped objects is established by using a convolution neural network (CNN) on the basis of simulating a human hand grasping objects. The model updates the loss function value and global step size by exponential decay and moving average, realizes the identification and classification of goods, and obtains the running dynamics of the program in real time by using visual tools. In addition, combined with the different characteristics of the data set, such as shape, size, surface material, brittleness, weight, among others, different intelligent grab solutions are selected for different types of goods to realize the automatic picking of goods of any shape in the picking list. Through the application of intelligent item grabbing in the storage field, it lays a foundation for the construction of an intelligent supply-chain system, and provides a new research perspective for cooperative robots (COBOT) in the field of logistics warehousing.
|
2022-07-04T21:27:28.369Z
|
158,345,163 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2991/COEMA-17.2017.21",
"MAG": "2751439839",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The purpose of this research to describe: (1) learning the values of mutual cooperation in the social studies grade IV SDN Mayangan I, Probolinggo, (2) the values of local wisdom Petik Laut District of Mayangan Probolinggo city, (3) the implementation of the values of mutual cooperation through local wisdom Petik Laut in social studies grade IV SDN Mayangan I Probolinggo city. Data were collected with a qualitative research method by observation, interviews, and documentation with community leaders, school principals, curriculum matters, and teachers. Type of research is descriptive and analytical results to use qualitative non-statistical data analysis, in the form of descriptive exposure. The results showed that (1) learning the values of mutual cooperation shows that students are already reflecting in part the character of mutual aid; (2) the values of local wisdom Petik Laut, such as: (a) the value of togetherness, (b) the value of tolerance, and (c) the value of mutual cooperation; (3) the implementation of the values of mutual cooperation through local wisdom Petik Laut showed that the students do with the activities of voluntary work, cooperation throw trash regardless of social status, and were able to share during a break, regardless of their gender, social status, religion or age difference.
|
2022-07-19T20:51:10.355Z
|
164,324,913 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/1369801X.2017.1337521",
"MAG": "2625083274",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In Inventing Ireland: The Literature of the Modern Nation (1996), the Irish critic Declan Kiberd argues “postcolonial writing does not begin only when the occupier withdraws: rather it is initiated at that very moment when a native writer formulates a text committed to cultural resistance”. While I agree with Kiberd that postcoloniality cannot be said to be synonymous with post-independence, in this essay I extend his formulation by adding another subversive initiator of the postcolonial moment, the sympathizing radical activist within the metropolis. I use the American case in relation to the Congo context in the nineteenth and early twentieth centuries to foreground my argument, especially with reference to the anticolonial activism of the African-American Presbyterian missionary William Sheppard and his co-worker Samuel Lapsley, and the anti-imperial stance of the American writer Mark Twain.
|
2022-09-10T15:50:41.837Z
|
25,190,201 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1099/00222615-5-1-109",
"MAG": "2122019629",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "http://jmm.microbiologyresearch.org/deliver/fulltext/jmm/5/1/medmicro-5-1-109.pdf?itemId=/content/journal/jmm/10.1099/00222615-5-1-109&mimeType=pdf&isFastTrackArticle="
}
|
Summary
A strain of Staph. aureus isolated from an infected wound showed firmly linked resistance to penicillin and kanamycin. Variants sensitive to both these antibiotics were produced spontaneously and at a high frequency during storage for a few days at ambient temperature.
Both sensitive and resistant variants produced a highly coloured diffusible pigment.
|
2022-09-10T19:37:34.021Z
|
94,912,959 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1021/IC00345A025",
"MAG": "2015210907",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The reactions of tetrakis (μ-2-anilinopyridinato) dirhodium(II, III) chloride, Rh 2 (ap) 4 Cl, with NaR or LiR, where R is the terminal acetylide ion (C≡CH, C≡CC 6 H 5 , C≡CC 5 H 11 , or C≡CC 4 H 8 C≡CH), results in the nucleophilic substitution of the axial chloride with the aliphatic group to form a Rh-C σ bond. The complex Rh 2 (ap) 4 (C≡CH), C 46 H 37 N 8 Rh 2 •CH 2 Cl 2 , crystallizes in the triclinic space group P1
|
2022-09-11T07:50:31.086Z
|
31,455,352 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2466/pr0.1986.58.1.95",
"MAG": "2052637951",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The disabling escape and avoidance behaviors of agoraphobics are known to be psychological sequelae to the onset of apparently spontaneous attacks of severe anxiety. Evidence is cited in favor of the view that such spontaneous panic attacks have a biological etiology and that the avoidance rituals and escape behavior of the agoraphobic may be accounted for in terms of superstitious conditioning. Although panic attacks subside within a few minutes, in most cases, regardless of the activities of the individual, ongoing operant behavior such as flight may be adventitiously reinforced by the removal of severe anxiety. Only a few such episodes may be required to establish superstitious avoidance. This analysis is supported by extensive clinical research indicating that an effective technique in alleviating agoraphobic behavior consists of exposing the patient for prolonged periods of time to anxiety-evoking situations while he refrains from all escape and avoidance behavior. This appears to weaken the apparent established contingency relationships between panic relief, and phobic escape and avoidance, and extinguishes such superstitious behavior.
|
2022-09-12T00:16:55.947Z
|
231,698,468 |
{
"externalids": {
"ACL": null,
"ArXiv": "2101.10275",
"DOI": "10.1021/acs.jpcb.1c04779",
"MAG": null,
"PubMedCentral": "8419842"
},
"license": "CCBY",
"status": "HYBRID",
"url": "https://pubs.acs.org/doi/pdf/10.1021/acs.jpcb.1c04779"
}
|
Responsiveness of polypeptides and polymers in aqueous solution plays an important role in biomedical applications and in designing advanced functional materials. Elastin-like polypeptides (ELPs) are a well-known class of synthetic intrinsically disordered proteins (IDPs), which exhibit a lower critical solution temperature (LCST) in pure water and in aqueous solutions. Here, we compare the influence of cis/trans proline isomerization on the phase behavior of single ELPs in pure water. Our results reveal that proline isomerization tunes the conformational behavior of ELPs while keeping the transition temperature unchanged. We find that the presence of the cis isomers facilitates compact structures by preventing peptide–water hydrogen bonding while promoting intramolecular interactions. In other words, the LCST transition of ELPs with all proline residues in the cis state occurs with almost no noticeable conformational change.
|
2022-10-05T14:21:30.405Z
|
57,439,729 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/ACC.1995.532220",
"MAG": "1639840331",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This paper deals with manipulator systems comprising a long-reach flexible manipulator (LRM) with a short-reach dextrous manipulator (SRM) attached to its end. The problem addressed is that of active damping, or vibration suppression, of the LRM by using SRM. The proposed solution uses the reaction force from SRM to LRM as a control variable and hence, it involves determining the motion of a rigid manipulator required to transmit a prescribed force to the supporting flexible arm. Performance of the active damping algorithm is illustrated with a 6-DOF rigid manipulator on a flexible mast.
|
2022-12-15T11:19:10.662Z
|
15,831,624 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1103/PHYSREVE.88.062513",
"MAG": "1982004508",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Chromonic liquid crystals are formed by molecules that spontaneously assemble into anisotropic structures in water. The ordering unit is therefore a molecular assembly instead of a molecule as in thermotropic liquid crystals. Although it has been known for a long time that certain dyes, drugs, and nucleic acids form chromonic liquid crystals, only recently has enough knowledge been gained on how to control their alignment so that studies of their fundamental liquid crystal properties can be performed. In this article, a simple method for producing planar alignment of the nematic phase in chromonic liquid crystals is described, and this in turn is used to create twisted nematic structures of both achiral and chiral chromonic liquid crystals. The optics of 90-degree twist cells allows the anchoring strength to be measured in achiral systems, which for this alignment technique is quite weak, about 3×10(-7) J/m(2) for both disodium cromoglycate and Sunset Yellow FCF. The addition of a chiral amino acid to the system causes the chiral nematic phase to form, and similar optical measurements in 90-degree twist cells produce a measurement of the intrinsic pitch of the chiral nematic phase. From these measurements, the helical twisting power for L-alanine is found to be (1.1±0.4)×10(-2) μm(-1) wt%(-1) for 15 wt% disodium cromoglycate.
|
2022-12-16T21:09:22.166Z
|
125,707,577 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/01621459.2017.1375932",
"MAG": "2760743788",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
ABSTRACT Probability weights are used in many areas of research including complex survey designs, missing data analysis, and adjustment for confounding factors. They are useful analytic tools but can lead to statistical inefficiencies when they contain outlying values. This issue is frequently tackled by replacing large weights with smaller ones or by normalizing them through smoothing functions. While these approaches are practical, they are also prone to yield biased inferences. This article introduces a method for obtaining optimal weights, defined as those with smallest Euclidean distance from target weights among all sets of weights that satisfy a constraint on the variance of the resulting weighted estimator. The optimal weights yield minimum-bias estimators among all estimators with specified precision. The method is based on solving a constrained nonlinear optimization problem whose Lagrange multipliers and objective function can help assess the trade-off between bias and precision of the resulting weighted estimator. The finite-sample performance of the optimally weighted estimator is assessed in a simulation study, and its applicability is illustrated through an analysis of heterogeneity over age of the effect of the timing of treatment-initiation on long-term treatment efficacy in patient infected by human immunodeficiency virus in Sweden.
|
2022-12-19T10:08:14.930Z
|
8,882,819 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1159/000380870",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Developing experimental models to understand dental caries has been the theme in our research group. Our first, the pH-cycling model, was developed to investigate the chemical reactions in enamel or dentine, which lead to dental caries. It aimed to leverage our understanding of the fluoride mode of action and was also utilized for the formulation of oral care products. In addition, we made use of intra-oral (in situ) models to study other features of the oral environment that drive the de/remineralization balance in individual patients. This model addressed basic questions, such as how enamel and dentine are affected by challenges in the oral cavity, as well as practical issues related to fluoride toothpaste efficacy. The observation that perhaps fluoride is not sufficiently potent to reduce dental caries in the present-day society triggered us to expand our knowledge in the bacterial aetiology of dental caries. For this we developed the Amsterdam Active Attachment biofilm model. Different from studies on planktonic (‘single') bacteria, this biofilm model captures bacteria in a habitat similar to dental plaque. With data from the combination of these models, it should be possible to study separate processes which together may lead to dental caries. Also products and novel agents could be evaluated that interfere with either of the processes. Having these separate models in place, a suggestion is made to design computer models to encompass the available information. Models but also role models are of the utmost importance in bringing and guiding research and researchers.
|
2022-12-19T09:56:21.798Z
|
229,449,330 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.21203/rs.3.rs-100428/v1",
"MAG": "3110610428",
"PubMedCentral": null
},
"license": "CCBY",
"status": "GREEN",
"url": "https://www.researchsquare.com/article/rs-100428/v1.pdf?c=1631862465000"
}
|
Chronic infection of HBV is a serious global health issue. However, the HBV covalently closed circular DNA (cccDNA) cannot be completely cleaned in liver. Here, we engineer a novel polypeptide, termed D-TTK001, targeting HBV X protein (HBx) against HBV cccDNA. D-TTK001 is a D-type polypeptide, which has a high binding affinity to HBx. Interestingly, it is able to against HBV efficiently in primary human hepatocytes (PHHs) from three donors. D-TTK001 displays high activities against HBV, remarkably reducing the levels of cccDNA in the HBV-infected human liver-chimeric mice. Mechanically, D-TTK001 depresses cccDNA transcription by regulating the epigenetic modification of cccDNA minichromosome and disturbing the interaction of HBx with DDB1 in the cells. D-TTK001 decreases the levels of cccDNA by down-regulating MSL2, leading to the increase of APOBEC3B in liver. When combined with entecavir or interferon-α, D-TTK001 shows additive antiviral effects. Clinically, D-TTK001 is a strong candidate to clear cccDNA against HBV.
|
2022-09-04T14:10:55.327Z
|
204,188,736 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3906/mat-1905-86",
"MAG": "2973609631",
"PubMedCentral": null
},
"license": "CCBY",
"status": "GREEN",
"url": "https://dergipark.org.tr/tr/download/article-file/894343"
}
|
The purpose of this paper is to determine derivations of the algebra Hα,β of generalized quaternions over the reals and hence to obtain the algebra Der(Hα,β) of derivations of Hα,β . Once we know derivations we might decompose Der(Hα,β) in terms of its inner and/or central derivations whenever they exist. Apart from Der(Hα,β) we would also be able to obtain generalized derivations, which have been studied by analysts in the context of algebras of some normed spaces, and of prime and semiprime rings.
|
2022-12-31T18:26:55.087Z
|
247,048,467 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1177/03611981221076843",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
During the peak hour, ridership is much higher, and this can lead to problems such as overcrowding for customers and vehicle bunching for the operator as dwell times increase for the lead bus. In this paper, we examined whether to avoid overcrowding people might be willing to wait for the next bus knowing there were seats and if they were offered an incentive. Three distinct types of incentive were offered, defined according to goal-framing theory. To obtain the choice data, a discrete choice experiment was developed and incorporated into an online survey that was distributed to public transport users. A binary logit model and a mixed multinomial logit model were used to investigate how different factors influence public transport users’ bus choice behavior. Results show several considerations that increase the likelihood of users agreeing to the request to wait. These include the weather being sunny/fine, not very cold, or both, the purpose being seeing a friend or shopping, longer in-vehicle time, shorter proposed bus waiting time, and the incentive. The results of the mixed multinomial logit model show variation among the respondents with regard to the incentives. We found that age, gender, work status, possession of a driver ID, and vehicle availability are significant predictors for incentive preference. In that our models target specific groups of users with tailored incentives, the results indicate how to persuade public transport users to avoid overcrowded buses.
|
2023-01-01T17:30:15.675Z
|
145,457,996 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3406/CARAV.1999.2834",
"MAG": "2082974027",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
RESUMEN-El destino historico de F. Solano Lopez coincide con una etapa dificil de la nacion paraguaya : la Guerra de la Triple Alianza." Este estudio basado en la obra literaria de A. Roa Bastos —Hijo de hombre, « El sonambulo » y El Fiscal— trata de mostrar los vinculos que la ficcion literaria construye y desconstruye entre heroe y nacion.
|
2022-02-09T06:31:51.211Z
|
120,787,354 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1121/1.424784",
"MAG": "1982788133",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Ocean medium fluctuations reduce the temporal coherence of acoustic signals. At low (e.g., 500 Hz) frequencies, temporal coherence limits the time duration of a replica field used for matched‐field source localization in a random ocean. At mid (e.g., 10 kHz) frequencies, temporal coherence of the acoustic signal dictates the update rate for the channel equalizer for a phase coherent communication scheme. In this paper, the temporal coherence of broadband acoustic signals is studied at low‐ and mid‐frequencies in a shallow‐water environment which includes both the linear and nonlinear (solitary) internal waves. The internal wave model is constructed based on the measured (average) sound‐speed profile and sound‐speed variance collected during the SWARM‐95 experiment. A broadband pseudorandom (PRN) signal is used at low‐ and midfrequencies. The signals are propagated using a PE model through the internal wave perturbed sound‐speed profiles which evolve in time according to the internal wave equation of motio...
|
2022-02-09T21:09:47.451Z
|
58,393,724 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.20287/EC.N27.V1.A08",
"MAG": "2906498073",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This document analyze the presence in digital platforms of first-person narrations that approach experiences related to motherhood from a critical point of view, in relation to the mandates and expectations of the dominant socio-sexual imaginaries. For women, lesbians, transvestites and trans, Internet has meant a powerful tool to think and narrate the world from a glance of their own. Some authors who enroll in cyberfeminism (Velasquez Herrera, 2015, Zafra, 2008, Haraway, 1985) consider that the possibility of socializing these other forms of narration, in a de-centered way in relation to the masculine, heterosexual, white and occidental vision – and without mediation of professional knowledge, academia or the publishing industry – has not only had positive consequences for women and dissident identities, it has also transformed the dynamics of circulation and access to non-hegemonic knowledges and positionings. Starting from the point of view of the feminist epistemology, which conceives all knowledge as situated (Haraway, 1985), we resort to a methodology based on semantic content analysis to approach a corpus composed of: the Facebook profile "Mama Mala"( Argentina) and the blog "Las dos mamis, virtual activism"(Mejico).
|
2022-02-11T17:28:39.868Z
|
249,262,681 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1093/sleep/zsac079.702",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://academic.oup.com/sleep/article-pdf/45/Supplement_1/A310/43843735/zsac079.702.pdf"
}
|
Positional obstructive sleep apnea (p-OSA) is commonly defined as a supine-position dependent OSA with the ratio of apnea hypopnea index while supine (s-AHI) to AHI while non-supine (ns-AHI) being greater than 2. Prevalence of p-OSA amongst OSA patients varies from 20 to 75% depending on the study. Previous studies using this definition showed p-OSA being more likely to be in subjects with lower BMI, smaller neck circumference, and milder OSA compared to patients with non-positional OSA (np-OSA). The primary aim of this study is to assess the prevalence of p-OSA using different cutoffs of s-AHI/ ns-AHI ratio and to evaluate the correlation of p-OSA with age, gender, neck circumference (NC), and medical comorbidities of OSA.
846 participants aged 18 year or older who underwent diagnostic polysomnography at an academic sleep disorders center from July 2011 to June 2012 were recruited for this study. Inclusion criteria were total sleep time greater than 120 minutes, diagnosis of OSA, sleep time in supine position more than 10 minutes, and sleep time in non-supine position more than 10 minutes. We tested supine position dependency using the ratio of supine AHI to non-supine AHI (s-AHI/ns-AHI) and classified the subjects into p-OSA and np-OSA based on the ratio of s-AHI/ns-AHI at 2, 3, 5, and 10 respectively to assess the prevalence of p-OSA using each cut-off. For the multivariable logistic analysis of p-OSA and its association with independent variables, s-AHI/ns-AHI of 10 and ns-AHI of being less than 5 was used to define p-OSA. Multivariate analysis was conducted to explore correlation with age, gender, neck circumference, and OSA comorbidities (COPD, hypertension, diabetes). Age of 60 was used to define older age group.
Of 356 eligible participants, p-OSA was highly prevalent when conventional s-AHI/ns-AHI ration of 2 was used resulting in p-OSA in 274 subjects (prevalence of 77%). The mean value of s-AHI/ns-AHI in this aggregate group of all 356 subjects was 11.7 (much higher than conventional ratio of 2). Thus, using s-AHI/ns-AHI ratio of 10 as the cut-off for supine-position dependency, 114 subjects were classified to have p-OSA. Logarithmic multivariate analysis demonstrated that there was a statistically significant, correlation between age and s-AHI/ns-AHI after adjusting for gender, NC, diabetes, hypertension, and COPD (p-value < 0.05). In the older group, 44.3% of older patient had s-AHI/ns-AHI > 10 compared to 30% of young patients (p-value < 0.05). 41.8% of the older group met criteria for p-OSA compared to 29.2% of younger group (p-value < 0.05). Being of older age was strong risk factor for p-OSA with odds ratio (OR) of 1.76 (confidence interval 1.01 – 3.09; p< 0.05). This effect of age on p-OSA was further modified by gender and diabetes. Older men had significantly higher OR of 3.23 (CI 1.51-6.89) for p-OSA whereas olde women was with OR of 0.79 (CI 0.33-2.42). Older persons with diabetes showed significantly higher OR than non-diabetic older persons (OR of 6.81 [CI 1.7-26.8] vs OR 1.22 [CI 0.65-2.29] respectively).
Supine-position dependency of obstructive events is much stronger than the conventional ratio of two. Thus, stricter definition is positional OSA is desired for more clinically meaningful use of this subgroup of OSA. Using stricter definition with higher supine-position dependency, an older age is significantly associated with positional OSA, especially in men or in diabetic patients.
|
2022-07-10T02:24:53.974Z
|
124,730,236 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2514/6.2016-2840",
"MAG": "2399399512",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "https://eprints.soton.ac.uk/396454/1/6%25252E2016-2840.pdf"
}
|
An advanced digital filter method is presented to generate divergence-free synthetic turbulence with homogeneous anisotropic velocity spectra. The resulting fluctuating velocity field is obtained through a superposition of anisotropic Gaussian eddies. This method is used to generate a two-dimensional turbulent flow with the key statistics of homogeneous axisymmetric turbulence. This type of turbulence has been reported in aero-engine intakes, fan wakes and open-jet wind tunnel experiments. The advanced digital filter method is implemented in a linearized Euler solver in order to investigate potential effects of anisotropic turbulence on leading edge noise. Computational aeroacoustic simulations are performed for anisotropic turbulence with streamwise-to-transverse length scale ratios ranging from 0.33 to 3 on a number of isolated airfoil configurations, including variations in mean flow Mach number, airfoil thickness and angle of attack. Noise reduction due to airfoil thickness is assessed on a NACA 0012 airfoil at zero angle of attack, showing similar trends for both isotropic and moderately anisotropic turbulent flows. Effects of anisotropic turbulence on noise become evident for airfoil configurations at non-zero angle of attack.
|
2022-09-19T14:12:47.734Z
|
248,016,907 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1088/1748-9326/ac64b6",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "https://doi.org/10.1088/1748-9326/ac64b6"
}
|
Agricultural irrigation has significantly reshaped the land surface energy and water balance. Previous studies have well investigated its cooling effect on air temperature (T air). However, its effect on increasing air humidity which can intensify the humid heat was often overlooked, particularly over urban areas with high population density, high T air, and consequently greater exposure to moist heat stress. In this study, using state-of-the-art reanalysis data at a high spatial resolution (∼9 km), we evaluated how changes in area equipped for irrigation (AEI) around a city affect urban moist heat stress (UMHS) in more than 1000 cities in China and India. In addition to T air, wet-bulb temperature (T WB) and wet-bulb globe temperature (T WBG), which consider humidity and are closer to the perceived temperature, were assessed. We found that although AEI expansion lowers urban T air, irrigation increases T WB and T WBG due to increased air humidity, thereby exacerbating the UMHS. This ‘warming’ effect of irrigation is more evident in northern India where AEI has expanded significantly in recent decades, and is prominent in the pre-monsoon and post-monsoon seasons, when precipitation and air humidity are low. However, this effect is not evident in China due to the lower intensity of AEI expansion and differing climatic conditions. Overall, this study highlights the side-effect of irrigation on regional climate, providing crucial information for better understanding urban heat stress and for future city planning.
|
2022-09-28T23:35:13.528Z
|
219,779,136 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1200/jco.2020.38.15_suppl.5534",
"MAG": "3029698543",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
5534Background: Comprehensive genomic profiling (CGP) was done on pre-systemic treatment (pre) PT, post-treatment (post) MET sites and LB in PC to uncover differences in genomic alterations (GA) an...
|
2022-01-27T02:29:49.569Z
|
241,225,000 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.51202/0947-7527-2021-18-057",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Angeführt von den Selbstständigen, bauen die Supermärkte seit Jahren erfolgreich ihre regionalen und lokalen Angebote aus. Den großen Discountern scheint hingegen nichts ferner zu sein als das Naheliegende – sie wirken wie gelähmt, wenn es darum geht, mehr Nähe zuzulassen. Den kleineren fällt das leichter. Doch was Regionalität heißt, davon hat jeder eine andere Vorstellung. Matthias Queck
|
2022-01-27T02:21:53.981Z
|
7,570,831 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1093/jac/3.suppl_B.129",
"MAG": "2121106992",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The comparative efficacy of pivmecillinam and amoxycillin in 243 patients with acute simple cystitis was determined in a randomized double-blind trial. Pivmecillinam was found to be significantly more effective on both clinical and bacteriological grounds. The superiority of pivmecillinam was primarily due to its efficacy in infections due to ampicillin resistant Escherichia coli. Fewer side effects were reported in patients who received pivmecillinam.
|
2022-06-23T15:35:25.146Z
|
161,882,178 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1353/wfs.2014.0032",
"MAG": "2031360226",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This essay examines the case of a lesser-known nineteenth-century female traveler: the French Romantic woman writer Sophie Cottin (1770-1807), who spent the last few months of 1806 traveling through Italy with a convalescing relative and writing letters home sharing her impressions. These letters have scholarly significance not only because they predate nineteenth-century French women's travel narratives examined elsewhere, but also because they offer insight into various other “journeys” Cottin completed during the final year of her life: reconciling the domesticity ideals of Jean-Jacques Rousseau she espoused with her work as a novelist (femininity versus fame) as well as weighing the influence of religion and ideology in her life (faith versus philosophy).
|
2022-09-08T06:16:57.229Z
|
17,457,164 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/ICICTA.2009.15",
"MAG": "2167348825",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The principal contribution of this paper is designed a general framework for an intelligent control system used in course angle control of remotely operated vehicle (ROV). A control scheme based on reinforcement learning (RL) agent combined with radial basis function (RBF) neural network control algorithm is applied. The effectiveness of the controller is demonstrated through simulations, and implementation issues are discussed. The control law is conceptually simple and computationally easy to implement.
|
2022-10-24T23:47:00.192Z
|
83,730,147 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1017/S003118200007030X",
"MAG": "1908633240",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Analysis of the egg counts of calves infected with one dose of larvae showed that they followed exactly the same course as those of calves infected daily, rising to a peak 25–30 days after infection and then decreasing logarithmically. An experiment in which calves were infected on a single occasion with different numbers of worms showed that faecal egg counts were not a reflection of worm numbers but were limited by a separate mechanism. Evidence is discussed which suggests that the number of eggs present in a female worm is not an entirely satisfactory measure of its rate of ovulation.
|
2022-12-15T03:06:58.420Z
|
21,736,856 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1093/BJA/80.5.660",
"MAG": "2103953639",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Respiratory infection is a major cause of morbidity after general anaesthesia. Impairment of respiratory ciliary beat frequency (CBF) by different stress factors causes a decrease in mucus transport rate (MTR). We have tested the effect of different concentrations of oxygen on CBF of human respiratory epithelium in a prospective, randomized, in vitro study. Samples of superficial mucosa of the inferior nasal turbinates of 20 non-smoking healthy volunteers were harvested and exposed to three different oxygen environments (group I = 21% oxygen, group II = 60% oxygen and group III = 95% oxygen) for 2 h. In 50% of the samples, exposure time was prolonged. At 30, 60, 90, 120 and 240 min, light microscopic images of cilia activity were videotaped and CBF was later assessed in slow motion. Compared with baseline, group I showed no difference in CBF throughout the study. CBF was increased in group II from mean 9.7 (SD 0.4) to 11.2 (0.4) Hz (16%, P < 0.001) and in group III from 9.5 (0.6) to 12.1 (0.5) Hz (28%, P < 0.001) at 120 min. After 240 min of exposure to 95% oxygen, the CBF trend in group III was reduced to 11.8 (0.6) Hz but still remained above baseline. We conclude that oxygen appeared to have a dose- and time-dependent accelerating effect on CBF. Prolonged exposure to high oxygen concentrations reversed this trend. Direct oxygen toxicity ("oxygen stress") is a possible explanation for this effect. These changes may result in impaired MTR.
|
2022-12-16T08:57:50.797Z
|
13,714,423 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1172/JCI96636",
"MAG": "2800595396",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
TNF is an important mediator in numerous inflammatory diseases, e.g., in inflammatory bowel diseases (IBDs). In IBD, acute increases in TNF production can lead to disease flares. Glucocorticoids (GCs), which are steroids that bind and activate the glucocorticoid receptor (GR), are able to protect animals and humans against acute TNF-induced inflammatory symptoms. Mice with a poor transcriptional response of GR dimer–dependent target genes were studied in a model of TNF-induced lethal inflammation. In contrast to the GRWT/WT mice, these GRdim/dim mice displayed a substantial increase in TNF sensitivity and a lack of protection by the GC dexamethasone (DEX). Unchallenged GRdim/dim mice had a strong IFN-stimulated gene (ISG) signature, along with STAT1 upregulation and phosphorylation. This ISG signature was gut specific and, based on our studies with antibiotics, depended on the gut microbiota. GR dimers directly bound to short DNA sequences in the STAT1 promoter known as inverted repeat negative GRE (IR-nGRE) elements. Poor control of STAT1 in GRdim/dim mice led to failure to repress ISG genes, resulting in excessive necroptosis induction by TNF. Our findings support a critical interplay among gut microbiota, IFNs, necroptosis, and GR in both the basal response to acute inflammatory challenges and pharmacological intervention by GCs.
|
2022-12-29T17:38:54.133Z
|
157,315,682 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.24914/jeb.v19i2.557",
"MAG": "2565623609",
"PubMedCentral": null
},
"license": "CCBYNCSA",
"status": "GOLD",
"url": "http://ejournal.uksw.edu/jeb/article/download/557/365"
}
|
This study aims to know whether the character of the entrepreneurial spirit of Ciputra University students which is expected to be the factor in being a successful enterprenour in the future, is influenced by parent who has a career as an independent enterprenour. The population of the study is students who have completed a minimum of two year study, have a sustainable business project at the time being, and have parents as family business entrepreneur. This is an exploratory qualitative research done by conducting in-depth interviews to students who become informants. Results from this study indicated that the character of the entrepreneurial spirit in the students themselves can be formed through an educational process, and also through action and the way of thought from parents in running the business. Character of entrepreneurial spirit is professionally sharpened the students in learning process at Ciputra University which is based on entrepreneurship.
|
2022-06-05T04:31:12.324Z
|
142,095,044 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1353/RHE.1986.0007",
"MAG": "242579524",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Abstract: The authors identify a “fifth generation” of community colleges and propose an agenda for priority research and methods of research to be implemented.
|
2022-08-29T05:41:58.974Z
|
214,208,766 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/LGRS.2019.2959660",
"MAG": "2998141712",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
There are two technical difficulties to overcome before obtaining a well-focused image from high squint (HS) synthetic aperture radar (SAR) with constant acceleration. One is effective range modeling and the other is the correction of space-variant (SV) Doppler parameters. Based on the imaging characteristics analysis, an orthogonal expansion range model (OERM) is proposed which can handle the coordinate rotation caused by range walk correction (RWC). Then a modified spectral analysis (SPECAN) with the Doppler resampling method is designed to correct the SV Doppler parameters. Finally, the proposed algorithm is verified by both simulated and real SAR data. Meanwhile, it shows an improvement in azimuth focusing quality over the reference one.
|
2022-11-27T23:19:33.605Z
|
42,340,681 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1177/000331977402500407",
"MAG": "2007197785",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A patient with Ehlers-Danlos syndrome (hypermobility of the joints, and hyperelasticity and fragility of the skin) associated with aortic regurgitation is reported. The aortic regurgitation appeared to be due to a combination of dilatation of the aortic ring and enlargement of the sinuses of Valsalva. Ehlers- Danlos syndrome is a rare cause of aortic regurgitation which occasionally, as in this patient, may be of clinical importance.
|
2022-12-18T00:36:44.714Z
|
83,906,894 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1086/323418",
"MAG": "1974560612",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The dicotyledonous family Styracaceae is distributed among all the major Tertiary mixed‐mesophytic forest refugia of the Northern Hemisphere. To infer the biogeographical history of the family and its significance for models of Northern Hemisphere historical biogeography, the phylogeny of the Styracaceae was estimated from separate and combined analyses of three DNA sequence data sets (chloroplast trnL intron/trnL‐trnF spacer, chloroplast rbcL gene, ITS region of nuclear ribosomal DNA) and a morphological data set of 47 characters. Up to 15 samples of other families of Ericales sensu the Angiosperm Phylogeny Group were employed as outgroups. The results strongly support the monophyly of the family. Dispersal‐vicariance analysis and Fitch parsimony optimization support a Eurasian origin of the Styracaceae, with subsequent dispersion to the Americas. This scenario is consistent with a hypothesized European origin for the family based on the fossil record. The eastern Asian–eastern North American disjunct genus Halesia is not supported as monophyletic. The sole Asian species of this genus groups with the Asian genus Rehderodendron, whereas the two North American species most often form parts of polytomies with other genera. The generally nested placement of the warm‐temperate deciduous species of Styrax within the amphi‐Pacific tropical evergreen group is consistent with an initial spread of the genus across the North Atlantic land bridge as part of the Eocene boreotropical flora and subsequent intercontinental dispersion of derived warm‐temperate‐adapted elements.
|
2022-12-24T17:58:00.647Z
|
129,095,516 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1029/2012JE004099",
"MAG": "2033021357",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
[1] The lack of magnetic anomalies within the major impact basins (Hellas, Argyre, and Isidis) has led many investigators to the conclusion that Mars' dynamo shut down prior to the time when these basins formed (∼4.0 Ga). We test this hypothesis by analyzing gravity and magnetic anomalies in the regions surrounding Tyrrhenus Mons and Syrtis Major, two volcanoes that were active during the late Noachian and Hesperian. We model magnetic anomalies that are associated with gravity anomalies and generally find that sources located below Noachian surface units tend to favor paleopoles near the equator and sources located below Hesperian surface features favor paleopoles near the geographical poles, suggesting polar wander during the Noachian-Hesperian. Both paleopole clusters have positive and negative polarities, indicating reversals of the field during the Noachian and Hesperian. Magnetization of sources below Hesperian surfaces is evidence that the dynamo persisted beyond the formation of the major impact basins. The demagnetization associated with the volcanic construct of Syrtis Major implies dynamo cessation occurred while it was geologically active approximately 3.6 billion years ago. Timing of dynamo activity is fundamentally linked to Mars' climate via the stability of its atmosphere, and is coupled to the extent and duration of surface geologic activity. Thus, the dynamo history is key for understanding both when Mars was most geologically active and when it may have been most hospitable to life.
|
2022-12-25T21:44:25.447Z
|
170,575,062 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1177/002096430006100108",
"MAG": "2021360775",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
THIS LECTIONARY SEGMENT OF PS 36 consists of five verses that express a confident trust in the Lord's steadfast love and two verses of a concluding prayer. If this passage were set aside and considered as a separate psalm, it would be categorized as a hymn of praise. In language that is as bold as it is poetic, the psalm draws a three-way intersection between God's character, God's creation, and God's covenantal salvation and protection. A clumsy interpreter might be tempted to separate the verses of trust from the verses of petition, but such a separation swims upstream against the witness of the psalm. The rhetorical impact is precisely that an indivisible unity exists between God's character and actions.
|
2022-01-27T18:38:24.613Z
|
131,752,586 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1093/AMT/28.1.E71",
"MAG": "2314041493",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The objective of the study was to evaluate the effectiveness of soil insecticide for management of cucumber beetles on seedling squash. Plots were located on the University of Arkansas Vegetable Station, Kibler, AR. Soil type is Roxanna silt loam. Plots consisted of a single six foot wide bed 35 ft long. Experimental design was RCB with four replications. Black Beauty zucchini squash was planted with a single cone Hege planter on 29 Apr 2002. Seed was placed every 1 ft within each plot. Insecticide treatments applied at planting were applied within the planting furrow with a single TeeJet 8002E nozzle positioned just behind the seed tube and in front of the press wheel. The sprayer was propelled with CO2 and calibrated to deliver 2864 ml per 1,000 row ft at 25 psi (126 ml/15 s). Planter speed was 2 mph or 341 s/1,000 row ft. Additional insecticide treatments were applied when adult cucumber beetles reached the threshold of two per seedling (two unfolded true leaves). Treatments were applied as described for the planting applications with the exception of treatment location which follows. A 1.5-inch wide plow with open bottom was fitted with the single nozzle of the sprayer and run with a Kubota tractor (4th gear at the rate 1900 rpm) approximately 3 inches from one side of the drill line. Depth was approximately 4 inches. Sampling was initiated on 16 May when plants had two true leaves. Five sample areas each 18 inch x 18 inch, were randomly selected along the drill line of each plot. Plants and ground within each of the five areas were searched for dead (inability to walk) striped and spotted cucumber beetles. Also, within each sample area the two cotyledon bottoms of each of two plants were rated for cucumber beetle feeding. Ratings ranged from 0 (no damage) to 5 (completely damaged). Data were analyzed with ANOVA and LSD.
|
2022-02-09T13:45:35.528Z
|
246,330,341 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1115/imece2021-70310",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Compared with traditional surgery, femtosecond laser minimally invasive surgery has many uncomparable advantages and will have a significant impact on the medical industry in the future. In this paper, a simple scene for laser minimally invasive virtual surgery training is designed, in which the testers can practice repeatedly until the basic operational requirements are met. The haptic device adopts the Geomagic Touch from American 3D Systems Company. Eight testers using Geomagic Touch handle perform four basic actions (clamping, adjusting posture, pushing / pressing, moving tiny objects) in the left interface virtual environment. Each action was performed 10 times by per tester. During the process of human-computer interaction, the position, attitude, speed, button and other information of the handle are collected in real time, and the collected data is saved in the form of text. The collected data is multivariate time series data. Based on the characteristics of multivariate time series data, this paper proposes a design of an evaluation system based on LSTM model to classify the collected data and evaluate the standard of surgical action according to the output probability of action classification.
|
2022-01-28T23:04:21.444Z
|
8,960,201 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3233/MAS-2012-0238",
"MAG": "1803085559",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Traditional statistical modeling in applied marketing is a huge area both for scientists and practitioners. Agent Based Models (ABM), on the other hand, are comparatively new field, yet gaining its weight very fast in last decade. The purpose of this article is to show some aspects of interrelations between these two types of models and address the common challenges, based on the concept of self-organized ABM. In particular, the complicated problems of semantic analysis of marketing texts and the extraction of the numerical values (a problem scarcely discussed in the literature) are considered; its importance is demonstrated on some examples from marketing texts. A Marketing Net Ontology draft version is proposed. An ABM for typical business web oriented process is designed. On its example it is shown, how problems of optimal ABM parameters tuning may be better understood using proposed statistical techniques.
|
2022-12-09T01:07:41.256Z
|
33,490,953 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1536/IHJ.50.259",
"MAG": "2018799469",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A 23-year-old woman with pre-excitation who was resuscitated from ventricular fibrillation underwent electrophysiologic testing. Successful catheter ablation of a left posteroseptal accessory pathway was achieved. Though the JT and JTc intervals as well as QT and QTc intervals were prolonged before and one day after the ablation, they normalized within about 5 hours after the ablation. This case demonstrated that in a patient with pre-excitation and long QT syndrome (LQTs), the JTc interval was useful for diagnosing LQTs and a longer follow-up of the JTc interval after the ablation was necessary in order not to miss the diagnosis of LQTs.
|
2022-12-11T06:52:07.028Z
|
88,356,162 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1093/NEUONC/NOV061.100",
"MAG": "2321563334",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Despite landmark advances in the genomics of medulloblastoma, significant ambiguity exists in the translation these findings into therapeutic advances. We propose that quantitative proteomics can be used to better discern driver aberrations and more directly view the functional, and therefore targetable, biology of this disease. METHODS: We created a Stable isotope Labeling of Amino acids in cell Culture (SILAC) reference atlas of proteins from 4 medulloblastoma cell lines and spiked it into cell lysates of low passage medulloblastoma cultures. A Hybrid LTQ-Orbitrap mass spectrometer was used to quantitate proteins relative to the atlas. RESULTS AND DISCUSSION: We used the SILAC reference atlas to quantitate the proteome of myc-amplified and non-myc-amplified group 3 low passage medulloblastoma cells. Accurate quantitation was achieved for an average of 1215 proteins per primary cell line. Technical replicates resulted in r2 values between 0.91 and 0.98. The differentially abundant proteins myc-amplified tumors reveal protein-protein connectivity networks associated with alternative splicing, ribosome biogenesis and metabolism. At the junction of splicing and metabolism, we confirmed the upregulation of specific splicing factors (HNRNPs) in the myc-amplified group. We demonstrate the HNRNP control of PKM isoform generation and the subsequent effect upon tumor cell metabolism and resistance to hypoxia. Furthermore, we confirm these proteomic findings using independent medulloblastoma tissue samples and show they are conserved in low passage primary tumor cultures. CONCLUSIONS: Our results demonstrate the advantages of quantitative proteomic profiling to discover oncogenic driver molecules. This is particularly significant given the emerging evidence of the poor correlation between mRNA abundance and protein abundance. Ultimately, insight into the protein level biology provided by these types of studies will yield more readily accessible therapeutic targets and allow clearer inferences of disease biology.
|
2022-02-10T20:36:59.620Z
|
32,973,168 |
{
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"ArXiv": null,
"DOI": "10.1080/03079458708436355",
"MAG": "2018072287",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Lesions of a contact dermatitis have resulted in serious downgrading of broiler carcases in the Northern Ireland poultry industry. A longitudinal survey was initiated to identify the important epidemiological factors involved in the occurrence of the condition. The results from the analysis of data from 986 flocks containing 12.6 million birds over a 2 year period, have quantified the effects which the major aspects of production have on the incidence of the condition in individual flocks. The stocking density, feed manufacturer, average age of removal and the sex of birds all had a profound effect. Lesions were more frequently recorded in flocks during the winter months and a strong correlation with the weather variable, relative humidity, obtained. Individual producers and houses varied in the incidence of the condition which was closely associated with the presence of poor litter conditions in the flocks.
|
2022-12-21T10:14:43.684Z
|
216,680,046 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.52948/ds.v1i2.97",
"MAG": "3015958968",
"PubMedCentral": null
},
"license": "CCBYNCND",
"status": "GOLD",
"url": "https://cipres.sanmateo.edu.co/ojs/index.php/designio/article/download/97/76"
}
|
El objetivo del presente artículo es realizar un análisis iconográfico e iconológico sobre la obra pictórica “La fusión de dos culturas” del muralista Jorge González Camarena. La finalidad es demostrar si la vestimenta de los guerreros presentes en la obra antes mencionada, corresponde al atavío. Lo anterior, con base en las fuentes arqueológicas que dan un acercamiento más preciso; también contextualiza, más a fondo, dónde se sitúan las representaciones pictóricas. Además, ofrece una respuesta a si estas son certeras según las fuentes arqueológicas y no solamente a lo que refieren las fuentes históricas.
|
2022-01-27T08:50:12.641Z
|
94,241,751 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/JCCS.198100038",
"MAG": "1943759670",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A facile and generally applicable procedure for acetylation of hindered phenols using tetra-n-butylammonium bromide as phase transfer catalyst and acetic anhydride as acetylation agent has been developed. The isolation yield is 85–91%.
|
2022-06-26T06:54:25.087Z
|
21,130,763 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1088/0953-8984/21/44/445701",
"MAG": "2102376813",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Electronic Raman scattering of two-band superconductors is studied based on the time-dependent Landau–Ginzburg theory. The focus is on the possible features of the π phase shift between the two superconducting order parameters which may be realized in the Fe-pnictides. The Raman response was computed up to the Gaussian fluctuations in the functional integral formalism including the long range Coulomb interaction with the four channels of symmetric and antisymmetric combinations of the phases and amplitudes of the two order parameters. The Raman spectra is found to be composed of the quasiparticle and the phase collective mode contributions without mixing between them. The contributions from the quasiparticle and the symmetric phase collective mode (the Anderson–Bogolyubov mode) are similar to the two-band superconductors without the π phase shift. The antisymmetric phase mode (the Leggett mode) originates from the fluctuations of the relative phase of the two order parameters. It lies between twice the smaller gap and twice the larger gap and is damped by the quasiparticles. However, this mode is eliminated by the long range Coulomb interaction in the zero-wavenumber limit.
|
2022-09-08T09:00:52.919Z
|
235,325,784 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1101/2021.06.01.446543",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBY",
"status": "GREEN",
"url": "https://www.biorxiv.org/content/biorxiv/early/2021/06/02/2021.06.01.446543.full.pdf"
}
|
Experimental studies reveal that genome architecture splits into DNA sequence domains suggesting a well-structured genomic architecture, where, for each species, genome populations are integrated by individual mutational variants. Herein, we show that, consistent with the fundamental theorem of Abelian finite groups, the architecture of population genomes from the same or closed related species can be quantitatively represented in terms of the direct sum of homocyclic Abelian groups of prime-power order defined on the genetic code and on the set of DNA bases, where populations can be stratified into subpopulations with the same canonical decomposition into p-groups. Through concrete examples we show that the architectures of current annotated genomic regions including (but not limited to) transcription factors binding-motif, promoter regulatory boxes, exon and intron arrangement associated to gene splicing are subjects for feasible modeling as decomposable Abelian p-groups. Moreover, we show that the epigenomic variations induced by diseases or environmental changes also can be represented as an Abelian group decomposable into homocyclic Abelian p-groups. The nexus between the direct sum of homocycle Abelian p-groups and the endomorphism ring paved the ways to unveil unsuspected stochastic-deterministic logical propositions ruling the ensemble of genomic regions. Our study aims to set the basis for concrete applications of the theory in computational biology and bioinformatics. Consistently with this goal, a computational tool designed for the analysis of fixed mutational events in gene/genome populations represented as endomorphisms and automorphisms is provided. Results suggest that complex local architectures and evolutionary features no evident through the direct experimentation can be unveiled through the analysis of the endomorphism ring and the subsequent application of machine learning approaches for the identification of stochastic-deterministic logical rules (reflecting the evolutionary pressure on the region) constraining the set of possible mutational events (represented as homomorphisms) and the evolutionary paths.
|
2022-11-25T16:30:22.857Z
|
24,750,149 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1136/bcr-2013-009841",
"MAG": "1983795251",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "https://europepmc.org/articles/pmc3762211?pdf=render"
}
|
Tuberculosis and malaria are two common diseases afflicting the population of the Indian subcontinent. Both are associated with fatal neurological complications. Clinically, it may be difficult to differentiate between the two, except for that the focal neurological complications are more common with central nervous system (CNS) tuberculosis than with cerebral malaria. We report the case of a 48-year-old woman who presented with a history of fever and altered sensorium of short duration. She was initially treated for falciparum malaria on the basis of positive peripheral smear and normal CT scan of the brain, but later on diagnosed to have CNS tuberculosis on the basis of persistence of symptoms, development of focal neurological symptoms and MRI of the brain showing multiple tuberculomas. She improved significantly with a course of antitubercular treatment (ATT) and systemic corticosteroids.
|
2022-12-18T01:24:35.837Z
|
35,756,750 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/pds.2085",
"MAG": "2134460568",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Maternal medication use during pregnancy is explored extensively, as it may cause birth defects. This study aimed to evaluate the validity of recorded medication use in the Medical Birth Registry of Norway (MBRN).
|
2022-12-16T02:22:25.337Z
|
5,543,061 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/ICCW.2015.7247489",
"MAG": "1575828036",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
We consider overloaded (non-orthogonal) code division multiple access multiuser wireless communication systems with many transmitting users and one central aggregation node, a typical scenario in e.g. machine-to-machine communications. The task of the central node is to detect the set of active devices and separate their data streams, whose number at any time instance is relatively small compared to the total number of devices in the system. We introduce a novel two-step detection procedure: the first step involves the simultaneous transmission of a pilot sequence used for identification of the active devices and the estimation of their respective channel coefficients. In the second step the payload is transmitted by all active devices and received synchronously at the central node. The first step reduces to a compressed sensing (CS) problem due to the relatively small number of simultaneously active devices. Using an efficient CS recovery scheme (approximate message passing), joint activity detection and channel estimation with high reliability is possible, even for extremely large-scale systems. This, in turn, reduces the data detection task to a simple overdetermined system of linear equations that is then solved by classical methods in the second step.
|
2022-12-26T22:07:50Z
|
51,926,728 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1093/femsyr/foy086",
"MAG": "2886366771",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://academic.oup.com/femsyr/article-pdf/18/8/foy086/25564229/foy086.pdf"
}
|
The red yeast Rhodosporidium toruloide is a versatile host for production of lipids and carotenoids. Genetic tools are underdeveloped for red yeasts due to their unique genetics and physiology. Currently expression of a heterogonous gene in red yeasts is largely based on integration of the designed cassette by Agrobacterium mediated transformation, yet this method is somewhat restricted when multiple genes are required to be expressed due to the lack of functional genetic elements. Here we demonstrate that virus 2A sequence is effective to mediate co-expression of multiple enzymes in R. toruloides. Two different 2A sequences, Porcine teschovirus-1 2A (P2A) and foot-and-mouth disease virus 2A (F2A), were evaluated. It was found that P2A sequence was more effective for co-expression of two antibiotic selection markers. Co-expression of three antibiotic resistance proteins was successful from a single promoter mediated by P2A sequence. When three heterogeneous enzymes responsible for β-carotene biosynthesis were co-expressed, recombinant R. toruloides strains produced up to 4.5-fold more β-carotene than that of the parental one. The use of 2A sequence can facilitate cassette construction to engineer advanced cell factories for production of lipids and related oleochemicals.
|
2022-12-27T23:06:45.364Z
|
255,213,028 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3390/jmse11010023",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.mdpi.com/2077-1312/11/1/23/pdf?version=1672017723"
}
|
In recent decades, coastal erosion phenomena have increased due to climate change. The increased frequency and intensity of extreme events and the poor sediment supply by anthropized river basins (dams, river weirs, culverts, etc.) have a crucial role in coastal erosion. Therefore, an integrated analysis of coastal erosion is crucial to produce detailed and accurate coastal erosion vulnerability information to support mitigation strategies. This research aimed to assess the erosion vulnerability of the Sicilian coast, also including a validation procedure of the obtained scenario. The coastal vulnerability was computed by means of the CeVI (Coastal Erosion Vulnerability Index) approach, which considers physical indicators such as geomorphology and geology, coastal slope, sea storms, wave maxima energy flux and sediment supply to river mouths. Each indicator was quantified using indexes which were assessed considering transects orthogonal to the coastline in 2020. These transects were clustered inside natural compartments called littoral cells. Each cell was assumed to contain a complete cycle of sedimentation and not to have sediment exchange with the near cells. Physical parameters were identified to define a new erosion vulnerability index for the Sicilian coast. By using physical indexes (geological/geomorphological, erosion/sediment supply, sea storms, etc.), the CeVI was calculated both for each littoral cell and for the transects that fall into retreating/advancing coastal areas. The vulnerability index was then validated by comparing CeVI values and the coastline change over time. The validation study showed a direct link between the coastline retreat and high values of CeVI. The proposed method allowed for a detailed mapping of the Sicilian coastal vulnerability, and it will be useful for coastal erosion risk management purposes.
|
2022-12-30T00:29:01.240Z
|
162,309,256 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1353/mfs.2014.0048",
"MAG": "2076185847",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This article examines the influence of Emmanuel Levinas’s philosophy on the ethical aspects of the life and work of André Schwarz-Bart. The essay is framed through recent re-interest in Schwarz-Bart’s collaborative works with his wife, Simone, as a bridge between Holocaust and postcolonial studies. The publications, arguments, and key points of intersubjective ethics in Levinas’s work that Schwarz-Bart encountered are carefully examined. The argument confronts the critical reception of Levinas’s concepts of the feminine and dwelling to demonstrate how, when seen through a Judaic lens, these notions form a new gendered reading of Schwarz-Bart’s The Last of the Just.
|
2022-02-08T21:47:54.864Z
|
225,532,630 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.22271/chemi.2020.v8.i4ac.10009",
"MAG": "3047476075",
"PubMedCentral": null
},
"license": null,
"status": "GOLD",
"url": "https://www.chemijournal.com/archives/2020/vol8issue4/PartAC/8-4-214-841.pdf"
}
|
An investigation on “Response of different iron sources on yield attributes and yield of pearlmillet cultivars" was carried out during kharif season 2019 at College of Agriculture, Rajendranagar. The experiment comprised of two cultivars of bajra as main plot treatments and five iron sources as subplot treatments tested under split plot design with 10 treatments and each treatment replicated three times. Pearlmillet hybrids PBH-1625 and HHB-67 were grown by adopting recommended package of practices. Higher yield attributes and yield were observed in PBH-1625 cultivar. Plant nutrients applied through inorganic fertilizer and in combinations with organic manures or iron sources showed significant effect on yield attributes and yield in different treatments. Application of iron through enriched FYM resulted in increased yield attributes and yield of pearl millet with T3 (FeSO4 fortified manure @ 500 kg ha) treatment.
|
2022-01-27T02:04:02.400Z
|
196,567,860 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1136/annrheumdis-2019-eular.8044",
"MAG": "2951928916",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://ard.bmj.com/content/annrheumdis/78/Suppl_2/564.1.full.pdf"
}
|
Background Fibrodysplasia Ossificans Progressiva (FOP), also known as a “second skeleton disease” is extremely rare (1: 2000000) and disabling genetic disorder, caused by mutation of ACVR1 gene, a bone morphogenetic protein receptor. Among medical specialties there are no certain, capable to provide not only diagnostics, but also all medical maintenance (assessment and monitoring of extent of damages, the differentiated drug treatment, rehabilitation, contact with adjacent experts). It would be reasonable if the rheumatologist carried out a role of the main attending physician for the patient with FOP. It seems to be a lot of similarities between rheumatic diseases, especially spondyloarthritis (SpA) and FOP in the pathophysiology, clinical manifestation and the therapy approach. Objectives: to present the single-center experience of the FOP patients and to identify similar symptoms in FOP and rheumatic disease. Methods The analysis of the large series of patients with FOP, who observed in the rheumatologic clinic. Results Our single center experience includes 26 patients with FOP. All 26 patients (13 male and 13 female) had 3 basic FOP clinical manifestations. In 23 patients molecular-genetic tests were performed and typical mutation (Arginine 206) occurred in 22 cases and one had an extremely rare mutation (Glicine 328). 22 (85%) patients had common for FOP massive heterotopic ossifications. 3 of them had formed heterotopic ossification through the X-ray negative stage to visible changes. Among typical phenotypic stigmas were: great toe malformation; thumbs malformation; peripheral osteochondromas; cervical spine abnormalities. Majority of the cases presented some similarities to SpA manifestations: ankylosis of the apophysial joints and vertebral bodies mostly in cervical spine; X-ray/CT evidence of the sacroiliitis in all patients, who were examined (n=8). Because of severe body deformity or metal details after previous surgery intervention there were no possibility to perform MRI in most patients, but we confirm typical sacroiliitis with extended bone edema on MRI in 3 patients. Recurrent episodes of the large joints synoviitis were present in 5 patients. 4 patients demonstrated gradually formation of great toe ankylosis during the follow-up observation. The involution and decreasing of new FOP nodes associated with non-steroidal anti-inflammatory drug intake and/or glucocorticoids therapy were occurred in all patients. Clinical features Male female Total N of patients Sex ratio 13 13 26 (1:1) Age of initial manifestations (years) <1 8 1 9 (35%) 1-9 6 8 14 (54%) >10 0 3 3 (11%) Great toe malformation 13 12 25 (96%) Thumbs malformation 2 3 5 (19%) Cervical spine abnormalities 12 9 21 (81%) Peripheral osteochondromas 8 7 15 (58%) Massive heterotopic ossifications 12 10 22 (85%) CT/X-Ray/MRI picture of sacroiliitis 2 (of 2) 6 (of 6) 8 of 8 (100%) Conclusion Appearance of the similarities in FOP and SpA manifestation and the therapy approach could identify FOP as a potential rheumatic disease. Clinical observation of FOP patients could provide the important information for rheumatologist about insufficiently explored process of new bone formation. Disclosure of Interests None declared
|
2022-02-08T07:04:08.402Z
|
96,529,410 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/JLAC.198219820321",
"MAG": "2055757454",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
1,4-Dithio-β-threofuranosides by Intramolecular Cyclisation of Dithiane Threoses
An exclusive formation of the β anomer of γ-halopropyl-1,4-dithio-threofuranosides occurs by intramolecular cyclisation of D-threose dithianes with a leaving group in terminal position involving a cyclic sulfonium intermediate.
|
2022-09-12T08:53:00.463Z
|
154,572,476 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/1467-8543.00134",
"MAG": "2078668817",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The term "high-performance work systems" is increasingly being used to label the transformed high-commitment organization associated with the abandonment of Taylorism. A fundamental issue is whether the whole ensemble of high-commitment and total quality management practices tend to be used together or in a fragmented ad hoc way. Latent trait analysis is used to address this question. Using data from Osterman's study of U.S. organizations, the analysis shows that certain practices do co-exist, though quality circle stands apart from them. While it is meaningful to talk of high performance management as an integration of modem quality and personnel management methods, caution must be exercised when defining management approaches in terms of a set of practices on a priori grounds alone.
|
2022-12-19T07:40:24.154Z
|
19,054,751 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/risa.12931",
"MAG": "2766143321",
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
Evacuation planning and management involves estimating the travel demand in the event that such action is required. This is usually done as a function of people's decision to evacuate, which we show is strongly linked to their risk awareness. We use an empirical data set, which shows tsunami evacuation behavior, to demonstrate that risk recognition is not synonymous with objective risk, but is instead determined by a combination of factors including risk education, information, and sociodemographics, and that it changes dynamically over time. Based on these findings, we formulate an ordered logit model to describe risk recognition combined with a latent class model to describe evacuation choices. Our proposed evacuation choice model along with a risk recognition class can evaluate quantitatively the influence of disaster mitigation measures, risk education, and risk information. The results obtained from the risk recognition model show that risk information has a greater impact in the sense that people recognize their high risk. The results of the evacuation choice model show that people who are unaware of their risk take a longer time to evacuate.
|
2022-12-19T21:37:33.782Z
|
16,208,948 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/PESW.2002.985022",
"MAG": "2009002756",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In this paper proposed method of maximum power point tracking using adaptive fuzzy logic control for grid connected photovoltaic system. The system composed of boost converter single-phase inverter connected to utility grid. The maximum power point tracking control is based on adaptive fuzzy logic to control MOSFET switch of boost converter and single phase inverter uses predicted current control to control four IGBTs switch for grid-connected control. Adaptive fuzzy logic controllers provide attractive features such as fast response, good performance and it can also change fuzzy parameter for improving control system. The fuzzy logic predicted current control provide current with sinusoidal waveshape and inphase with voltage. This system can provide energy with low harmonics and high power factor.
|
2022-12-20T04:19:52.588Z
|
15,867,541 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/j.1756-8765.2012.01214.x",
"MAG": "2050113433",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1756-8765.2012.01214.x"
}
|
Following in a psychological and musicological tradition beginning with Leonard Meyer, and continuing through David Huron, we present a functional, cognitive account of the phenomenon of expectation in music, grounded in computational, probabilistic modeling. We summarize a range of evidence for this approach, from psychology, neuroscience, musicology, linguistics, and creativity studies, and argue that simulating expectation is an important part of understanding a broad range of human faculties, in music and beyond.
|
2022-12-26T18:59:05.691Z
|
39,620,531 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1001/JAMA.281.17.1618",
"MAG": "2157420579",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
CONTEXT
Genetic testing for hereditary nonpolyposis colon cancer (HNPCC) is available, but the rates of acceptance of testing or barriers to participation are not known.
OBJECTIVE
To investigate rates and predictors of utilization of genetic testing for HNPCC.
DESIGN
Cohort study conducted between July 1996 and July 1998.
SETTING
Hereditary nonpolyposis colon cancer family registry.
PARTICIPANTS
Adult male and female members (n = 208) of 4 extended HNPCC families contacted for a baseline telephone interview.
INTERVENTIONS
Family education and individual genetic counseling.
MAIN OUTCOME MEASURE
Participant acceptance of HNPCC test results.
RESULTS
Of the 208 family members, 90 (43%) received test results and 118 (57%) declined. Of 139 subjects (67%) who completed a baseline telephone interview, 84 (60%) received test results and 55 (40%) declined. Of the 84 subjects who received test results, 35 (42%) received information indicating that they had HNPCC-associated mutations and 49 (58%) that they did not. Test acceptors had higher education levels (odds ratio [OR], 3.74; 95% confidence interval [CI], 2.49-5.61) and were more likely to have participated in a previous genetic linkage study (OR, 4.30; 95% CI, 1.84-10.10). The presence of depression symptoms significantly reduced rates of HNPCC test use (OR, 0.34; 95% CI, 0.17-0.66). Although rates of test use were identical among men and women, the presence of depression symptoms resulted in a 4-fold decrease in test use among women (OR, 0.25; 95% CI, 0.08-0.80) and a smaller, nonsignificant reduction among men (OR, 0.49; 95% CI, 0.19-1.27).
CONCLUSIONS
Despite having significantly elevated risks of developing colon cancer, a relatively small proportion of HNPCC family members are likely to use genetic testing. Barriers to test acceptance may include less formal education and the presence of depression symptoms, especially among women. Additional research is needed to generalize these findings to different clinical settings and racially diverse populations.
|
2022-12-26T21:57:05.087Z
|
228,493,915 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3760/CMA.J.ISSN.1006-7876.2010.10.014",
"MAG": "3029164474",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
临床资料患者男性,66岁,因"行动、反应慢10余年,意识障碍2 d"于2010年3月23日入院.该患者于10余年前出现行动慢,身体僵硬,行走时小步态,并有反应慢、淡漠、记忆力差、睡眠少.上述症状渐加重,入院前半个月不能行走、少语、进食差、发热,体温达39 ℃,并出现发作性抽搐,发作时意识不清,伴二便失禁.入院前7 d出现意识障碍,在当地医院补液及抗炎治疗1 d后意识转清,但进食仍不佳,继续上述药物治疗,入院前2 d再次发生意识障碍.既往有双眼白内障手术史,否认颈部外伤及甲状腺手术史。
|
2022-01-23T03:47:30.304Z
|
148,892,147 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.18800/AGENDA.201701.004",
"MAG": "2768873377",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Regardless of the difficult scenario facing the Paris Agreement with the recent withdrawal of the US, Peru will continue to comply with its international obligations and consolidating its national policies and frameworks related to climate change. Although Peru entered the international negotiation process late – basically from COP 20 onwards- it has had a decisive participation and influence in its outcome, the Paris Accord. Pero has for over a decade, been developing a robust internal architecture of norms and institutions, to launch the country towards a greener economy. With the difficulties that this means for a developing country like Peru, the future leads inevitably to the search of clean and environmentally friendly and sustainable economies.
|
2022-02-09T04:39:16.090Z
|
23,722,004 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/j.1440-1843.2001.00292.x",
"MAG": "3034388778",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Objective: The first case reports of infection with penicillin‐resistant pneumococci were made in Australia in 1967 and South Africa in 1977. Since this time the increasing emergence of penicillin‐ resistant strains of Streptococcus pneumoniae have been a serious therapeutic problem. Therefore, the aim of the present study was to determine the penicillin resistance of S. pneumoniae strains isolated in the laboratory. The effect of procaine penicillin treatment against these strains was also investigated.
|
2022-02-12T19:09:27.352Z
|
10,094,913 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1152/AJPLEGACY.1960.198.4.797",
"MAG": "147991653",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In order to evaluate the effects of the chronic uremic syndrome upon some aspects of carbohydrate metabolism in vivo , determinations of gastric and intestinal glucose absorption, and of hepatic glycogen deposition were made in 39 chronically uremic rats and in 49 litter-mate controls. A surgical method for producing chronic uremia was developed. Rats fasted for 24 hours were given a glucose gavage of standard concentration. Three hours later residual gastric and intestinal glucose content and liver glycogen content were determined. No statistically significant difference between the two groups was found in either glucose absorption from the gastrointestinal tract or in glycogen deposition.
|
2022-09-01T04:19:19.098Z
|
117,183,160 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1515/dema-2004-0122",
"MAG": "265727822",
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
It is defined a new almost complex structure with Norden metric (hyperbolic metric) on the tangent bundle TM of an n—dimensional Riemannian manifold M. Next, the conditions under which the considered almost complex structure with Norden metric belongs to one of the eight classes of almost complex manifolds with Norden metric obtained by G. T. Ganchev and D. V. Borisov in the classification from [2] there are studied.
|
2022-11-24T17:21:39.863Z
|
216,501,937 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/tcc.2020.2983402",
"MAG": "3014359533",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The Internet of Things continuously generates avalanches of raw sensor data to be transferred to the Cloud for processing and storage. Due to network latency and limited bandwidth, this vertical offloading model, however, fails to meet requirements of time-critical data-intensive applications which must act upon generated data with minimum time delays. To address such a limitation, this article proposes a novel distributed architecture enabling stream data processing at the edge of the network, broadening the principle of enabling processing closer to data sources adopted by Fog and Edge Computing. Specifically, this architecture extends the Apache NiFi stream processing middleware with support for run-time clustering of heterogeneous edge devices, such that computational tasks can be horizontally offloaded to peer devices and executed in parallel. As opposed to vertical offloading on the Cloud, the proposed solution does not suffer from increased network latency and is thus able to offer 5-25 times faster response time, as demonstrated by the experiments on a run-time license plate recognition system.
|
2022-12-12T04:28:15.414Z
|
9,405,452 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/BIBE.2009.7",
"MAG": "2152809162",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Gene and protein structural and functional annotations expressed through controlled terminologies and ontologies are paramount especially for the aim of inferring new biomedical knowledge through computational analyses. However, the available annotations are incomplete, in particular for recently studied genomes, and only a few of them are highly reliable human curated information. To support and speed up the time-consuming curation process, prioritized lists of computationally predicted annotations are hence extremely useful. In this paper we leverage a previous work on the automatic prediction of Gene Ontology annotations based on the singular value decomposition (SVD) of the gene-to-term annotation matrix, and we propose a novel post-processing method that uses a Bayesian network to eliminate predictions of anomalous annotations. In fact, we observed that the predicted annotation profiles might suggest that a gene shall be annotated to a term, but not to one of its ancestors, thus violating the constraint imposed by the Gene Ontology. To this end, the proposed algorithm processes the annotation profiles predicted by a SVD based method, and produces a ranked list of computationally discovered candidate annotations which is consistent with the Gene Ontology.
|
2022-12-15T22:36:31.041Z
|
162,200,412 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2307/939268",
"MAG": "2039610402",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
When there are many people who don't need to expect something more than the benefits to take, we will suggest you to have willing to reach all benefits. Be sure and surely do to take this richard strauss the staging of his operas and ballets that gives the best reasons to read. When you really need to get the reason why, this richard strauss the staging of his operas and ballets book will probably make you feel curious.
|
2022-07-31T08:35:01.349Z
|
137,038,146 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/LFNM.2003.1246068",
"MAG": "2102446774",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Single-mode operation of a 2-D (square lattice geometry) antiguided vertical cavity surface emitting laser (VCSEL) array was studied numerically. The VCSEL array is composed of transversely uniform layers including the Bragg mirrors, thin spacer and loss layers located between elements and active layer consisted of 3 quantum wells. Besides, the output facet is patterned by windows in the metal electrode. The lasing mode was found as a result of an iterative procedure consisting of light round-trips in the device and active layer recalculations based on solution of 2D nonlinear diffusion equation for charge carriers. 3D bi-directional beam propagation method was developed for round-trip calculation. For linear stability analysis a number of higher-order optical modes were found in the VCSEL array with gain and index distributions established by the oscillating mode. The in-phase mode with constant phase over the array, out-of-phase mode with alternating phase between elements and modes with mixed symmetry were considered. Calculations were made for various lengths of spacings between elements and sizes of the array. 4x4 and 5x5 laser arrays were studied numerically. Favourable conditions were found for lasing the in-phase mode providing high laser beam quality.
|
2022-09-23T18:11:42.055Z
|
12,160,855 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.7554/eLife.14511",
"MAG": "2293486660",
"PubMedCentral": "4798958"
},
"license": null,
"status": null,
"url": null
}
|
A new study reveals that the ROCK proteins play key roles in the formation of tumours in mice.
|
2022-10-14T00:12:22.553Z
|
7,058,251 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4212/CJHP.V68I1.1420",
"MAG": "2163243994",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
BACKGROUND
Dabigatran, a direct thrombin inhibitor, is indicated for the prevention and treatment of venous thromboembolism and for stroke prophylaxis in atrial fibrillation. The manufacturer recommends that dabigatran etexilate be retained in the original packaging until administration. Currently, no information exists about the stability of dabigatran etexilate outside its original packaging.
OBJECTIVE
To evaluate the stability of dabigatran etexilate capsules over 120 days, with storage in the manufacturer's original packaging, in unit-dose packaging, and in community pharmacy blister packaging.
METHODS
Commercially available dabigatran etexilate capsules (110 mg) were stored at room temperature (25°C) in the manufacturer's original blister pack, in unit-dose packaging, or in community pharmacy blister packs. Samples were collected from each container daily for the first 3 days, weekly up to 28 days, every other week until day 98, and at day 120. Suspensions were prepared, pH was evaluated, and samples were stored at -85°C until analysis. Each sample was analyzed in duplicate by a validated, stability-indicating high-performance liquid chromatography - ultraviolet detection method. The capsules were considered stable if they maintained at least 90% of the initial concentration.
RESULTS
Dabigatran etexilate capsules maintained 100.4% of the original concentration with 120 days of storage in the manufacturer's original blister pack, 98.7% with storage in unit-dose packaging, and 98.0% with storage in community pharmacy blister packs. There were no notable changes in appearance, ease of suspension of the capsule content, or pH over the 120-day period.
CONCLUSION
Dabigatran etexilate 110-mg capsules were stable for 120 days with storage at room temperature in 3 types of packaging widely used in hospital and community settings.
|
2022-09-05T09:20:46.581Z
|
121,956,664 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1063/1.3681380",
"MAG": "2020684791",
"PubMedCentral": null
},
"license": "CCBY",
"status": "GREEN",
"url": "https://bibliotecadigital.exactas.uba.ar/download/paper/paper_00218979_v111_n4_p_Godoy.pdf"
}
|
We report micrometric periodic assembly of live and dead magnetotactic bacteria, Magnetospirillum magneticum AMB-1, which synthesize chains of magnetic nanoparticles inside their bodies, and of superparamagnetic Fe3O4 and ferromagnetic CoFe2O4 nanoparticles in aqueous suspensions using periodically magnetized audio tapes. The distribution of the stray magnetic field at the surface of the tapes was determined analytically and experimentally by magneto-optic imaging. Calculations showed that the magnetic field close to the tape surface was of the order of 100 mT, and the magnetic field gradient was larger than 1 T mm−1. Drops of aqueous solutions were deposited on the tapes, and bacteria and particles were trapped at locations where magnetic energy is minimized, as observed using conventional optical microscopy. Suspensions of M. magneticum AMB-1 treated with formaldehyde and kanamycin were studied, and patterns of trapped dead bacteria indicated that magnetic forces dominate over self-propelling forces in ...
|
2022-09-12T10:33:55.631Z
|
12,780,786 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1371/journal.pone.0115496",
"MAG": "1997062623",
"PubMedCentral": "4275244"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0115496&type=printable"
}
|
Pancreatic adenocarcinoma (PA) is among the most aggressive human tumors with an overall 5-year survival rate of <5% and available treatments are only minimal effective. WNT/β-catenin signaling has been identified as one of 12 core signaling pathways that are commonly mutated in PA. To obtain more insight into the role of WNT/β-catenin signaling in PA we established human PA cell lines that are deficient of the central canonical WNT signaling protein β-catenin by using zinc-finger nuclease (ZFN) mediated targeted genomic disruption in the β-catenin gene (CTNNB1). Five individual CTNNB1 gene disrupted clones (BxPC3ΔCTNNB1) were established from a BxPC-3 founder cell line. Despite the complete absence of β-catenin, all clones displayed normal cell cycle distribution profiles, overall normal morphology and no elevated levels of apoptosis although increased doubling times were observed in three of the five BxPC3ΔCTNNB1 clones. This confirms that WNT/β-catenin signaling is not mandatory for long term cell growth and survival in BxPC-3 cells. Despite a normal morphology of the β-catenin deficient cell lines, quantitative proteomic analysis combined with pathway analysis showed a significant down regulation of proteins implied in cell adhesion combined with an up-regulation of plakoglobin. Treatment of BxPC3ΔCTNNB1 cell lines with siRNA for plakoglobin induced morphological changes compatible with a deficiency in the formation of functional cell to cell contacts. In addition, a re-localization of E-cadherin from membranous in untreated to accumulation in cytoplasmatic puncta in plakoglobin siRNA treated BxPC3ΔCTNNB1 cells was observed. In conclusion we describe in β-catenin deficient BxPC-3 cells a rescue function for plakoglobin on cell to cell contacts and maintaining the localization of E-cadherin at the cellular surface, but not on canonical WNT signaling as measured by TFC/LEF mediated transcription.
|
2022-11-20T17:42:14.426Z
|
32,094,974 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/TNS.2013.2280799",
"MAG": "2081346816",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Scattered events represent a major cause of inaccurate quantification and image degradation in three-dimensional (3D) positron emission tomography (3D PET) scanners. The single scatter simulation (SSS) method is the most widely used scatter correction method. However, this method relies on tail data to scale the estimated scatter to the measured data. Consequently, this method might fail when tail data are insufficient; for example, when scanning obese patients. Unfortunately, the global prevalence of obesity has increased substantially in recent decades; hence, developing alternative solutions to this problem is necessary. The beam stopper (BS) method is used to measure the actual scatter at locations blocked by the BS device. This method can then be applied to estimate the entire scatter sinogram by using an interpolation. However, this interpolation might not reflect the true condition if the BS device has been set up inappropriately. This study presents a hybrid scatter correction method (SSS-BS) based on the SSS and BS methods. In the SSS-BS method, the scatters measured by applying the BS method are used to adjust the scatter distribution calculated by employing the SSS method, thereby obtaining a more accurate scatter distribution. The performance of this hybrid method was investigated by using Monte Carlo simulations. A thorax Zubal phantom (55.8 cm in width and 37.8 cm in height) and a Jaszczak-like phantom (55.2 cm in diameter and 22.75 cm in length) were used to investigate cases involving obese patients. In contrast to the SSS method, the hybrid method does not suffer from the scatter-distribution inaccuracies caused by insufficient tails. The results from the Zubal phantom show that the SSS-BS, SSS, and BS methods yield similar scatter-fraction (SF) estimates, whereas the SSS-BS and SSS methods have a slightly smaller root mean square error (RMSE) of reconstructed images than that of the BS method. For the Jaszczak-like phantom, the SSS-BS method generates a more accurate estimate of SF than both the SSS and BS methods do, reducing the RMSE by nearly half. This study demonstrates that the hybrid method enables the accurate scatter-distribution estimation of 3D PET in cases involving obese patients.
|
2022-12-17T10:51:32.487Z
|
44,582,489 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1136/bjsm.2007.037192",
"MAG": "2101208345",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "https://europepmc.org/articles/pmc2465243?pdf=render"
}
|
In soccer one of the most common knee injuries is the anterior cruciate ligament (ACL) tear, which usually occurs through non-contact mechanisms. Female soccer players are at higher risk of sustaining non-contact ACL injuries than male soccer players. A good understanding of ACL loading mechanisms is the basis for a good understanding of the mechanisms of non-contact ACL injuries, which in turn is essential for identifying risk factors and developing prevention strategies. Current literature demonstrates that sagittal plane biomechanical factors, such as small knee flexion angle, great posterior ground reaction force and great quadriceps muscle force, are the major ACL loading mechanisms. A great posterior ground reaction force may be associated with a great quadriceps muscle force, which would cause great anterior draw force at the knee. A small knee flexion is associated with a large patella tendon-tibia shaft angle and ACL elevation angle, which would result in great ACL loading. Current literature also demonstrates that the ACL is not the major structure of bearing knee valgus-varus moment and internal-external rotation loadings. Knee valgus-varus moment and internal-external rotation moment alone are not likely to result in isolated ACL injuries without injuring other knee structures.
|
2023-01-01T17:22:37.143Z
|
188,100,219 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.25157/JIMAG.V4I3.1650",
"MAG": "2920151845",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Kecamatan Jatiwaras, Kabupaten Tasikmalaya merupakan daerah pengembangan kedelai yang diharapkan mampu mendorong perekonomian daerah. Penelitian ini bertujuan untuk mengetahui tingkat kesejahteraan rumah tangga petani kedelai di Kecamatan Jatiwaras, dalam 1 tahun. Metode yang digunakan dalam penelitian ini adalah survei. Teknik pengumpulan data dengan wawancara menggunakan kuesioner dengan jumlah responden sebanyak 42 orang petani kedelai. Parameter penelitian meliputi 11 indikator tingkat kesejahteraan menurut BPS dalam SUSENAS 2007, yaitu: pendapatan, pengeluaran, keadaan tempat tinggal, fasilitas tempat tinggal, kesehatan anggota rumah tangga, kemudahan mendapatkan pelayanan kesehatan, kemudahan memasukan anak kejenjang pendidikan, kemudahan mendapatkan fasilitas transportasi, kehidupan beragama, rasa aman, dan kemudahan berolahraga. Berdasarkan 11 indikator BPS dalam SUSENAS 2007 nilai kesejahteraan rumah tangga petani kedelai di Kecamatan Jatiwaras adalah 30,85. Hal ini dikategorikan dalam kesejahteraan tinggi yang artinya rumah tangga petani kedelai keadaan pendapatan, pengeluaran, kesehatan, tempat tinggal, dan fasilitas-fasilitas penunjang sudah memenuhi kebutuhan dengan layak. Kata kunci : kedelai, rumah tangga petani kedelai, tingkat kesejahteraan
|
2022-01-24T22:30:48.146Z
|
129,648,130 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1063/1.2807754",
"MAG": "2058921940",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The phrase “geologic time” conjures images of continents moving at centimeters per year, or of mountains forming and eroding over hundreds of millions of years. Yet, some geologic processes evolve at a rate that allows significant changes to take place on the scale of a human lifetime. Earth's magnetic field changes on a time scale of decades—presumably mirroring changes in the planet's electrically conducting, fluid outer core, the motion of which is thought to generate and sustain the geomagnetic field. Last year, Gary Glatzmaier (Los Alamos National Laboratory) and Paul Roberts (University of California, Los Angeles) generated the most realistic model yet of this “geodynamo,” and predicted that the rotation rate of Earth's inner core evolves on a scale of centuries rather than eons. Moreover, in their simulation the magnetic field and the flow of the fluid outer core caused the solid inner core nearly always to spin more rapidly than the mantle and crust—the result of magnetic coupling between the inne...
|
2022-01-27T15:11:24.763Z
|