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255M
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132,012,722 |
{
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"DOI": "10.1061/(ASCE)HE.1943-5584.0001422",
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|
AbstractAn important goal of combining weather radar with rain gauge data is to provide reliable estimates of rainfall rate and accumulation and to further identify intense precipitation and issue flood warnings. Scanning radars provide the ability to observe precipitation over wider areas within shorter timeframes compared to rain gauges, leading to improved situational awareness and more accurate and reliable warnings of future precipitation and flooding events. The focus of this study is on evaluating the performance of the multi-radar multi-sensor (MRMS) system with and without the impact of a local gap filling radar. The challenge of using radar and rain gauges to provide accurate rainfall estimates in complex terrain is investigated. The area of interest is the Russian River basin north of San Francisco, CA, which lies within the National Oceanic and Atmospheric Administration (NOAA) Hydrometeorology Testbed (HMT). In this complex mountainous terrain, the challenge of obtaining reliable quantitative...
|
2022-09-17T14:58:02.254Z
|
220,730,676 |
{
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"DOI": "10.3892/or.2020.7673",
"MAG": "3038547291",
"PubMedCentral": "7388243"
},
"license": "CCBYNCND",
"status": "HYBRID",
"url": "https://www.spandidos-publications.com/10.3892/or.2020.7673/download"
}
|
Pancreatic cancer is a severe disease with high morbidity and mortality. However, the primary molecular mechanisms of pancreatic tumor formation and progression remain unclear. The present study using sequencing technology revealed that the centromere protein M (CENPM) gene was overexpressed in pancreatic cancer tissues. CENPM is one of the components of a complex that plays a central role in kinetochore protein assembly, mitotic progression and chromosome segregation. However, the biological function of CENPM in pancreatic cancer has yet to be determined. Hence, two effective siRNAs were designed to knock down CENPM. Notably, downregulation of CENPM inhibited pancreatic cancer cell proliferation, altered the cell cycle and limited pancreatic cancer cell migration and invasion via the mTOR/p70S6K signaling pathway. This research provides new evidence that CENPM overexpression plays a significant role in the progression of pancreatic cancer. Overall, the present findings indicated that CENPM may be a significant biomarker for predicting the development and progression of pancreatic malignancy.
|
2022-10-18T18:40:42.315Z
|
248,783,823 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2169/internalmedicine.9365-22",
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"PubMedCentral": null
},
"license": null,
"status": "GOLD",
"url": "https://www.jstage.jst.go.jp/article/internalmedicine/61/23/61_9365-22/_pdf"
}
|
Background Pituitary inflammation due to IgG4-related disease is a rare condition and is sometimes accompanied by central diabetes insipidus. Central diabetes insipidus produces a strong thirst sensation, which may be difficult to distinguish when complicated by salivary insufficiency. Case presentation A 45-year-old man was admitted to our department for a thorough examination of his thirst and polyuria. He had suddenly developed these symptoms more than one year earlier and visited an oral surgeon. Swelling of the left submandibular gland, right parotid gland, and cervical lymph nodes had been observed. Since his IgG4 level was relatively high at 792 mg/dL and a lip biopsy showed high plasmacytoid infiltration around the gland ducts, he had been diagnosed with IgG4-related disease. He had started taking 0.4 mg/kg/day of prednisolone, and his chief complaint temporarily improved. However, since the symptom recurred, he was referred to our institution. After admission, to examine the cause of his thirst and polyuria, we performed a water restriction test, vasopressin loading test, hypertonic saline loading test and pituitary magnetic resonance imaging. Based on the findings, we diagnosed him with central diabetes insipidus due to IgG4-related hypophysitis. We increased the dose of prednisolone to 0.6 mg/kg/day and started 10 μg/day of intranasal desmopressin. His symptoms were subsequently alleviated, and his serum IgG4 level finally normalized. Conclusion We should remember that IgG4-related disease can be accompanied by hypophysitis and that central diabetes insipidus is brought about by IgG4-related hypophysitis. This case report should remind physicians of the fact that pituitary inflammation due to IgG4-related disease is very rare and can be masked by symptoms due to salivary gland inflammation, which can lead to pitfalls in the diagnosis in clinical practice.
|
2022-12-10T09:15:38.511Z
|
5,864,915 |
{
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"DOI": "10.1053/j.jrn.2008.08.011",
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|
OBJECTIVE
This study used the health belief model (HBM) and the transtheoretical model (TTM) to assess hemodialysis (HD) patients' readiness to comply with recommended fluid intake as it relates to their perceptions of therapy and disease.
DESIGN
This was a multicenter, cross-sectional study.
SETTING
The setting involved 3 hospital-based HD centers in Lebanon.
PATIENTS
Patients included 172 consenting HD patients who had been on HD for at least 3 months and were mentally stable.
INTERVENTION
Placement of patients into TTM stages was based on their readiness to comply with recommended fluid intake, as confirmed by 4-week interdialytic weight-gain measures, and taking into account their perceptions toward therapy (using HBM constructs).
MAIN OUTCOME MEASURES
Mean scores of HBM constructs for each patient were placed in one of the TTM stages of readiness to change.
RESULTS
This study included 54.1% males, the average age was 57.8 +/- 14.0 (SD) years, and average number of years on dialysis was 4.6 +/- 4.9. Regarding stages, 18.5% of participants were placed in precontemplation, 40.0% in contemplation, 38.1% in preparation, and 3.4% were in the action/maintenance stages. The HBM constructs were significantly associated with TTM (P < .01). Perceptions of benefits (P = .04) and self-efficacy (P < .01) were significantly associated with TTM.
CONCLUSION
Compliance is a multifaceted topic, essential for the survival and quality of life of HD patients. A better understanding of patients' beliefs and level of self-efficacy is a fundamental key to enhancing patients' compliance to therapy and achieving the required behavioral modifications.
|
2022-12-19T08:52:27.084Z
|
14,955,977 |
{
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"ArXiv": null,
"DOI": "10.1099/0022-1317-80-11-2813",
"MAG": "2135999995",
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"license": null,
"status": "BRONZE",
"url": "https://doi.org/10.1099/0022-1317-80-11-2813"
}
|
A full-length cDNA copy of the genome of Potato leafroll virus (PLRV) was introduced into the genome of tobacco and potato plants by Agrobacterium tumefaciens-mediated transformation. Transgenic lines were obtained in which the transgene was readily detected by PCR with DNA extracted from T(1) tobacco seedlings and clonally multiplied potato plants. PLRV-specific genomic and sub- genomic RNAs, coat protein antigen and virus particles were detected in transgenic plants. Aphids fed on the transgenic tobacco plants readily transmitted PLRV to test plants. Infected transgenic tobacco plants, like non-transgenic (WT) PLRV-infected plants, displayed no symptoms of the infection but transgenic plants of potato were severely stunted. In parallel tests, the mean PLRV titres in WT tobacco plants and transgenic tobacco plants were 600 and 630 ng virus/g leaf, respectively, although differences in PLRV titres among transgenic plants were much greater than those among infected WT plants. In similar tests with potato, the mean PLRV titre of WT plants was 50 ng virus/g leaf whereas higher concentrations (up to 3400 ng virus/g leaf) accumulated in transgenic potato plants. In tissue prints of stems, PLRV was detected in similar proportions of phloem cells in transgenic and infected WT plants. In transgenic tobacco and potato plants, but not in infected WT plants, a few stem epidermal cells also contained virus. From tissue prints of transgenic tobacco leaves, it was estimated that about one in 40000 mesophyll cells contained virus, but in transgenic potato, a greater proportion of mesophyll cells was infected.
|
2022-12-20T15:47:38.278Z
|
718,277 |
{
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"DOI": "10.1002/iub.44",
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"status": "CLOSED",
"url": null
}
|
Mitochondria play a key role in death signaling. The intermembrane space of these organelles contains a number of proteins which promote cell death once they are redistributed to the cytosol. The formation of pores in the outer membrane of mitochondria defines a gateway through which the apoptogenic proteins pass during death signaling. Interactions between pro‐apoptotic and pro‐survival members of the Bcl‐2 family of proteins are decisive in the initiation of pore opening. While the specific composition of the pore in molecular terms is still subject to debate and continuing investigation, it is recognized functionally as a passive channel which not only allows egress of proteins to cytosol but also entry in the reverse direction. A variety of constraints may restrict the release of proteins from the intermembrane space to the cytosol. These include trapping in the intercristal spaces formed by the convoluted invaginations of the inner membrane, binding of proteins to the inner membrane or to other soluble proteins of the intermembrane space, or insertion of proteins into the inner membrane. There is a corresponding variety of mechanisms that facilitate release of apoptogenic proteins from such entrapment. Morphological changes that expand the inner membrane enable proteins to be released from enclosure in intercristal spaces, allowing these proteins access to the mitochondrial gateway. Specific cases include cytochrome c molecules bound to inner membrane cardiolipin and released upon oxidation of that lipid component. Further, AIF that is embedded in the inner membrane is released by proteases (caspases or calpains), which enter from the cytosol once the outer membrane pore has opened. The facilitation (or restriction) of apoptogenic protein release through the mitochondrial gateway may provide new opportunities for regulating cell death. © 2008 IUBMB IUBMB Life, 60(6): 383–389, 2008.
|
2022-12-21T09:59:47.615Z
|
38,507,493 |
{
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"ArXiv": null,
"DOI": "10.1111/j.1600-0536.2006.00931.x",
"MAG": "2104101401",
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},
"license": null,
"status": "CLOSED",
"url": null
}
|
There are very few reports on hypersensitivity reactions in association with titanium‐based materials so that the existence of allergy to titanium is still put in question. We report on a patient in whom impaired fracture healing and eczema localized to the perioperative area developed upon titanium‐based osteosynthesis. Patch testing gave no reactions to titanium nor to nickel, chromium, or cobalt. However, in the lymphocyte transformation test, the patient’s lymphocytes showed markedly enhanced proliferation in vitro to titanium. After removal of the titanium material, fracture healing was achieved and the eczema cleared. Parallel to this, in vitro hyperreactivity to titanium disappeared. Although contact allergic reactions to titanium have been very rarely reported, these findings support a diagnosis of titanium allergy in our patient.
|
2022-12-21T10:01:23.808Z
|
243,172,697 |
{
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"DOI": "10.1093/oso/9780190080495.003.0011",
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|
The term “Gross National Happiness” or GNH emerged in the 1970s, when journalists asked Bhutan’s Fourth King about his country’s gross national product. The young king’s reply, that “Gross National Happiness is more important than gross national product,” clearly articulated his vision that the happiness and well-being of the country, rather than simply its economic output, should be the focus of the country’s development....
|
2022-01-27T02:00:31.827Z
|
214,709,088 |
{
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"DOI": "10.21608/jppp.2015.75439",
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},
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"status": "BRONZE",
"url": "https://jppp.journals.ekb.eg/article_75439_68921c936ba0eb0df06a3074a126c86e.pdf"
}
|
Echinostoma liei (Jeyarasasingam, Heyneman, Lim and Mansour, 1972), was used for the first time as bio control agent for the wild rat Rattus rattus frugivorus Rafinesque . Two levels of infection were used (250 and 500 metacercariae / rat ) and histopathological alterations were studied in the affected organs ( intestine ,liver and testis ) . The investigation revealed that high infection of E. liei resulted in severe pathological alteration in rat intestine, and liver, such as edema, lymphocytic infiltration, necrosis and hemorrhage in the liver lead to death in addition to testis hypertrophy with seminiferous tubules devoid of sperms that may lead to sterility. Thus, E. liei could be considered a new effective biological agent for controlling wild rats causing either death or sterility and also safe to human since people in Egypt don’t eat fresh water snails either raw or cocked ).
|
2022-01-27T03:00:05.363Z
|
107,752,342 |
{
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"ArXiv": null,
"DOI": "10.1109/IECON.1994.397974",
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|
A fractal method is applied to a measurement technique for complicated patterns of floc in a wastewater treatment process in this study. A fractal dimension is calculated in a simple procedure using online sampled image data taken by ITV camera in a flocculation process. The image data indicate complicated patterns and they are numerated with the fractal dimension. The more complicated the pattern is, the bigger the fractal dimension is. When the fractal dimension is maximum, the density and the size of floc are also maximum, and the water content of floc is minimum. Experimental data testify that the proposed fractal method is useful for the wastewater treatment process in a food producing factory.<<ETX>>
|
2022-02-10T07:34:55.494Z
|
80,153,210 |
{
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"DOI": "10.1183/1393003.CONGRESS-2017.PA4962",
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|
Introduction: Studies suggest that high blood EOS count may be a marker of increased exacerbation risk in COPD patients (pts) with a history of exacerbations. We investigated the effect of blood EOS count on the efficacy of roflumilast (ROF) on COPD exacerbation rate. Methods: A post-hoc analysis was performed on two trials (REACT [NCT01329029], RE2SPOND [NCT01443845]) in which pts with severe COPD and ≥2 exacerbations in the previous year were randomised to ROF 500μg od or placebo (PBO) added to ICS/LABA±LAMA for 52 weeks. Primary endpoint was rate of moderate or severe COPD exacerbations/pt/year. Exacerbation rates were analysed by baseline EOS cell count strata ( Results: Of 4287 pts, 2146 had an EOS count ≥150 cells/mm3 at entry. ROF reduced moderate or severe exacerbations rates by 19.1% (p=0.002) in pts with EOS ≥150 cells/mm3 and by 3.8% (p=0.605) in pts with EOS Conclusions: In this post-hoc analysis, PBO-treated COPD pts with higher blood baseline EOS counts had more exacerbations. Pts with higher blood baseline EOS counts derived greater benefit from ROF in exacerbation risk reduction compared to PBO.
|
2022-07-01T18:04:16.924Z
|
234,542,425 |
{
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"ArXiv": null,
"DOI": "10.1109/tg.2020.3042900",
"MAG": "3110872353",
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"url": null
}
|
Error-related potential (ErrP) are a particular type of Event-Related Potential (ERP) elicited by a person attending a recognizable error. These Electroencephalographic (EEG) signals can be used to train a gaming agent by a Reinforcement Learning (RL) algorithm to learn an optimal policy. The experimental process consists of an observational human critic (OHC) observing a simple game scenario while their brain signals are captured. The game consists of a grid, where a green spot has to reach a desired target in the fewest amount of steps. Results show that there is an effective transfer of information and that the agent successfully learns to solve the game efficiently, from the initial 97 steps on average required to reach the target to the optimal number of 8 steps. Our results are expressed in threefold: (i) the mechanics of a simple grid-based game that can elicit the ErrP signal component, (ii) the verification that the reward function only penalizes wrong steps, which means that type II error (not properly identifying a wrong movement) does not affect significantly the agent learning process; (iii) collaborative rewards from multiple observational human critics can be used to train the algorithm effectively and can compensate low classification accuracies and a limited scope of transfer learning schemes.
|
2022-07-10T06:03:28.458Z
|
88,123,630 |
{
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"ArXiv": null,
"DOI": "10.1093/AESA/64.3.603",
"MAG": "2330076864",
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},
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"url": null
}
|
The female reproductive system of Schizaphis graminum (Rondani) consists of 2 ovaries (each composed of 5 telotrophic ovarioles), lateral oviducts, median oviduct, and genital chamber. The ovaries and lateral oviducts are derived from 3 mesodermal tissues: anterior ovarian strands, primary epithelial sheaths, and posterior ovarian strands. The genital chamber arises as a ventral invagination between the 7th and 8th abdominal segments during early postparturition. The median oviduct arises from ectodermal ampullae within the 7th abdominal segment. The genital chamber joins with the central mass of the median oviduct, and these eventually develop confluent lumina.
Reproductive system development begins in embryos within postparturienic nymphs, and all organ development is complete by 50 hours postparturition.
|
2022-08-26T04:41:50.889Z
|
225,476,152 |
{
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"ArXiv": null,
"DOI": "10.3390/catal10080932",
"MAG": "3049408576",
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},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.mdpi.com/2073-4344/10/8/932/pdf?version=1597313470"
}
|
In polymer electrolyte membrane fuel cells (PEMFCs) for fuel cell electric vehicles, cell reversal (CR) at the anode side can occasionally occur—usually when hydrogen supply is interrupted—which results in degradation of the anode. To mitigate this problem, reversal-tolerant anodes (RTAs) using oxygen evolution reaction catalysts have been generally applied. Adding such materials promotes water oxidation and, thus, provides the protons and electrons during CR situation, while minimizing the carbon-oxidation reaction. In this study, we performed a detailed investigation of the sole use of IrxRuy/C catalysts for RTAs in the membrane electrode assembly (MEA)—including the effects of the IrRu alloy composition and the degree of graphitization of the carbon support on the durability under fuel starvation. Supported IrRu alloy catalysts with different Ir/Ru ratios were prepared via a facile impregnation method on carbon supports with differing degrees of graphitization by heat-treatment at a range of high temperatures. X-ray diffraction patterns indicated that the crystal structure of the alloy nanoparticles depended on the alloy composition, showing the development of a hexagonal closely packed structure with increasing Ru content. Raman spectroscopy indicated an increase in the degree of graphitization of carbon with progressively higher processing temperatures. IrxRuy alloys were found to be a suitable replacement for Pt anode from single-cell MEA performance testing. Furthermore, we examined the synergic enhancement of the CR durability of IrRu alloys with different compositions comparing to the Ir and Ru metals by measuring the initial and total voltage change of MEAs under hydrogen starvation. For the same alloy composition, higher CR durability was observed for MEAs with catalysts prepared using a higher degree of graphitization of the carbon support. Based on the results, we concluded that to develop efficient catalysts for RTAs of automotive PEMFCs, it is important to consider both the durability of the carbon support under high voltages and the catalyst composition.
|
2022-09-12T07:14:50.076Z
|
55,016,899 |
{
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"DOI": "10.4236/NS.2013.510130",
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},
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}
|
Iraq is part of West Asia and North Africa (WANA) region. The area is known as dry land, famous with gap of crop yield as a result of the water shortage problem. Six basins with total catchment area of 614.19 km 2 at rain-fed of Northern Sinjar District (Iraq) had been chosen to investigate both of the potential of rainwater harvesting (RWH) and three supplemental irrigation (SI) scenarios S1, S2, and S3 (100%, 75%, and 50% of full irrigation requirement) to support the wheat yield (bread and durum) under various rainfall conditions for the study period 1990-2009. The results indicated that, the total volume of harvested runoff can be considered for irrigation practices, that reached up to 42.4, 25.1, 0.6, 10.9 (× 10 6 m 3 ) during 1995-1996, 1996-1997, 1998-1999, and 2001-2002, respectively. The total irrigated area ranged between 10.9 - 5163.7 and 8.8 3595.7 (ha) for bread and durum wheat crop for the four selected seasons respectively. The yield scenarios for supplemental irrigation condition Y1, Y2, and Y3 give 68 - 9712, 94 - 12,999, and 105 - 22,806 Ton for bread wheat, and for durum wheat give 56 - 8035, 87 - 10,906, and 103 - 17,396 Ton.
|
2022-12-07T17:01:30.547Z
|
254,387,990 |
{
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"DOI": "10.22452/mjcs.sp2022no2.5",
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},
"license": null,
"status": "BRONZE",
"url": "https://ejournal.um.edu.my/index.php/MJCS/article/download/40414/15137"
}
|
Biomedical image processing and decision making is a growing research demand under global pandemic situation. The quality of medical images plays a vital role in streamlining remote diagnosis and processing via telemedicine platform, in providing unambiguous results and decision supports. This paper presents an improved Medical Image Content Quality (MICQ) technique and it aims to enrich the Magnetic Resonance (MR) image content or pixels based on semi supervised clustering technique for the process of deeper analysis and investigation to identify the normal and abnormal portions. The proposed (IMICQ) system is containing three stages namely pre-processing, clustering and validation respectively. In the pre-processing stage, the MICQ divides the MR image into finite number of non-overlapping blocks or vectors with size (2*2). Next stage, the proposed MICQ system iteratively partitions the MR image dataset or vector set into optimum number of highly relative dissimilar clusters based on K-Means clustering technique. In the last stage, the proposed system measures the quality of clustering result which obtained in the previous stage based on Effective Cluster Validation Measure (ECVM). Experimental results show that the MICQ is better suitable to improve MR image content quality for telemedicine platform and to predict the normal and abnormal portions over the image with higher accuracy ratio.
|
2022-12-10T10:00:13.977Z
|
82,056,872 |
{
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"DOI": "10.21236/ada280927",
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},
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"url": null
}
|
Abstract : The goal of the EPSCoR project is to conduct these assays in channel catfish (Ictalurus punctatus) preparations and to make the study a comparative toxicology study. During the first year of the project, Mr Carr has optimized the catfish brain membrane preparation for the assay of 35S-TBPS blinding. He has expanded his background in neurochemistry to learn receptor binding methods and calculation of receptor saturation experiments for the calculation of Kd and Bmax, and he has extended his experience with radioisotope procedures and calculations. He has studied the competition of 12 of the available organochlorine compounds with 35TPBS binding to catfish brain membranes. The compounds selected for study were chosen based on high, moderate and low potency in the rat brain system. The results thus far indicate a much lower concentration of GABA receptors per unit wet weight in catfish brain compared to rat brain. In general, the organochlorine compounds tested thus far have demonstrated similar relative potency in the catfish brain as in the rat brain. Results were submitted for presentation at the Society of Toxicology annual meeting, Dallas, Texas, March, 1994. Studies of the interference of the compounds with 36C1- flux will be initiated in the second year.
|
2022-02-11T02:18:15.541Z
|
109,024,357 |
{
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"DOI": "10.1111/J.1936-704X.2013.03155.X",
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"status": null,
"url": null
}
|
Large amounts of water are required for electricity generation, and demand for thermoelectric power is predicted to increase significantly over the next several decades. Of concern, is that nearly half of this new demand is in regions currently subject to fresh water shortages due to over-appropriation, drought, and climatic drivers. This study explores the suitability of using non-traditional sources of water, namely wastewater and brackish ground water for future thermoelectric cooling in 22 continental Electricity Market Module Regions. Both sources pose unique financial, technical, and management challenges, but are widely available and in the majority of instances economically feasible. While neither resource can meet all future demand by thermoelectric generation, when added to the existing water supply and management portfolio, they provide significant augmentation to existing traditional water supplies.
|
2022-08-24T10:32:02.475Z
|
123,675,441 |
{
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"DOI": "10.3934/DCDSB.2011.16.669",
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|
In this paper we are concerned with a class of nonlinear
degenerate elliptic equations under the natural growth. We show
that each bounded weak solution of $A$-harmonic type equations
under the natural growth belongs to local Holder continuity
based on a density lemma and the Moser-Nash's argument. Then we
show that its weak solution is of optimal regularity with the
Holder exponent for any $\gamma$: $0\le \gamma<\kappa$, where
$\kappa$ is the same as the Holder's index for homogeneous
$A$-harmonic equations.
|
2022-08-27T06:21:07.251Z
|
3,677,482 |
{
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"DOI": "10.1097/BCR.0b013e3181db5250",
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"url": null
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|
Clinically, the initial blanching in burn scar seen on transparent plastic face mask application seems to diminish with time and movement requiring mask alteration. To date, studies quantifying perfusion with prolonged mask use do not exist. This study used laser Doppler imaging (LDI) to assess perfusion through the transparent face mask and movement in subjects with and without burn over time. Five subjects fitted with transparent face masks were scanned with the LDI on four occasions. The four subjects without burn were scanned in the following manner: 1) no mask, 2) mask on while at rest, 3) mask on with alternating intervals of sustained facial expression and rest, and 4) after mask removal. Images were acquired every 3 minutes throughout the 85-minute study period. The subject with burn underwent a shortened scanning protocol to increase comfort. Each face was divided into five regions of interest for analysis. Compared with baseline, mask application decreased perfusion significantly in all subjects (P < .0001). Perfusion did not change during the rest period. There were no significant differences with changing facial expression in any of the regions of interest. On mask removal, all regions of the face demonstrated a hyperemic effect with the chin (P = .05) and each cheek (P < .0001) reaching statistical significance. Perfusion levels did not return to baseline in the chin and cheeks after 30 minutes of mask removal. Perfusions remain constantly low while wearing the face mask, despite changing facial expressions. Changing facial expressions with the mask on did not alter perfusion. Hyperemic response occurs on removal of the mask. This study exposed methodology and statistical issues worth considering when conducting future research with the face, pressure therapy, and with LDI technology.
|
2022-09-16T02:47:18.770Z
|
148,699,939 |
{
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"DOI": "10.1177/2043820617752005",
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"license": null,
"status": null,
"url": null
}
|
Phillips and Smith’s attempt to refresh (rural) gentrification theory is successful as they provide a prolific set of epistemological comparative threads and substantiate this position via analysis of the UK, France and the US cases. Nevertheless, in my opinion, academia should go beyond the Western European/North American comfort zone and embrace theoretical and epistemological complexity, the currently extended and variegated planetary space presents.
|
2022-12-11T05:00:09.089Z
|
85,080,615 |
{
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"DOI": "10.1093/JXB/29.5.1099",
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"status": null,
"url": null
}
|
Growth and catechol oxidase activity were followed in suspension cultures of cells derived from apple fruit. In cultures which required the addition of hormones, enzyme activity was affected by 2,4-D (2,4-dichlorophenoxyacetic acid) and kinetin via their effect on growth. Exogenous hormones did not affect catechol oxidase activity of habituated cultures. Ethylene and PC IB (a-4 chlorophenoxyisobutyric acid) rapidly depressed enzyme activity in all cell fractions, but only at concentrations which repressed growth. Ethionine caused an immediate decrease in enzyme activity which preceded the repression of growth. Ethionine did not inhibit enzyme activity in vitro. Possible mechanisms of the action of ethionine are discussed and the formation of a specific inhibitor is
|
2022-12-16T14:25:37.882Z
|
163,905,369 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1017/S0035869X00087396",
"MAG": "2312558880",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
PERIODE PARTHE. By GHOLAM-REZA KIAN. 10 x 6£, pp. 251, figs. 10. Paris : Paul Geuthner, 1934. Frs. 60. The first part of this work deals with the origins of money from the early barter stage down through the later period of metallic currency to the appearance of coinage properly speaking. Some account is also given of the Babylonian contribution to the history of weights and measures. The second part particularizes the coinage of ancient Persia as far as the end of the Parthian dynasty. There is nothing original in the author's fairly readable account of the subject. He has made use of the standard authorities. But as a Doctor of the University of Paris one would expect a closer attention to one of the fundamentals of research work, accuracy in the matter of references. The bibliography is tragic. Page 246, for example, is a mass of errors. One rather suspects the author's scholastic equipment when Niitzel's Berlin catalogue of the oriental coins in the Konigliche Museen is referred to as the work of Ester (sic) Band and Zweiter Band as well as of Koniglich (sic). And it is distressing to find Gholam-Reza Kian making reference (p. 238) to Firdausl's Ghah-Nameh (sic).
|
2022-07-08T20:53:35.123Z
|
10,569,744 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.21873/anticanres.12135",
"MAG": "2987134757",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "http://ar.iiarjournals.org/content/37/12/6749.full.pdf"
}
|
BACKGROUND/AIM
Combination therapies are often explored to treat cancer. The use of curcumin as an adjuvant to current chemotherapies has been reported, whilst aminonaphthoquinones have shown potential as anticancer agents in various tumour cell lines. This study aimed at screening synthetic aminonathoquinone derivatives (Rau 008, Rau 010, Rau 015 and Rau 018) alone and in combination with curcumin for anti-breast cancer activity.
MATERIALS AND METHODS
Combination effects were determined in MCF-7 breast cancer cells using combination index analyses. Synergistic anti-proliferative effects were further investigated in breast (MCF-7, MDA-MB-231), osteosarcoma (MG-63) and endometrial (HEC-1A) cancer-derived cells.
RESULTS
Rau 015 (15 μM) and curcumin (112.5 μM) significantly reduced MCF-7, MDA-MB-231 and MG-63 cell proliferation compared to individual treatment, indicating synergistic anti-proliferative effects. Rau 018 (30 μM) and curcumin (100 μM) displayed similar effects in MCF-7 and MG-63 cells.
CONCLUSION
We report on the potential of Rau 015 or Rau 018 as anti-breast cancer agents when combined with curcumin.
|
2022-11-13T17:32:36.122Z
|
121,954,843 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/ULTSYM.1994.401612",
"MAG": "2162760404",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In the effort to continually reduce the size and cost of wireless communications products the level of integration has improved dramatically in recent years. In order to reduce future generations of wireless systems to single chip form, there is a need for on-chip filtering capabilities. In this paper the first report of an experimental waveguide-coupled resonator filter for cellular radio applications is presented. Measured results indicate a typical insertion loss of 26 dB at a center frequency of 132 MHz using a 2 um AlN film on {001}<110> Si. In addition a laser probe analysis has been conducted and a theoretical analysis of the first order reflection coefficients is presented
|
2022-09-12T10:36:01.787Z
|
8,826,162 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1073/PNAS.85.2.622",
"MAG": "1974670594",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Dynorphin, an opioid peptide, is thought to play an important role in the modulation of nociceptive neural circuits at the level of the spinal cord. In a model of peripheral inflammation and hyperalgesia, an oligodeoxyribonucleotide probe complementary to a portion of preprodynorphin mRNA and antisera to dynorphin A-(1-8) were used to localize changes in dynorphin mRNA and peptide to individual spinal cord neurons. Intraplantar injection in rats of complete Freund's adjuvant resulted in edema and hyperalgesia to radiant heat stimulation of the injected hind paw that reached a peak at 4 days. At the same time, in situ hybridization histochemistry and immunocytochemistry identified an increase in transcription of preprodynorphin mRNA that was paralleled by an increase in dynorphin peptide. These changes were seen in spinal neurons in the medial two-thirds of laminae I and II and in laminae V and VI of lumbar segments receiving innervation from the inflamed paw. Since neurons demonstrating the increase in dynorphin biosynthesis are located in both the superficial and deep dorsal horn laminae, our data provide evidence for opioid modulation of nociceptive neural circuits in these two distinct spinal locations.
|
2022-12-19T10:03:55.077Z
|
73,522,778 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/SLCT.201800683",
"MAG": "2801167789",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
By means of MP2 and DFT computations we predict gas-phase acidities and liquid-phase (MeCN) acidities of (di)carboxylic acids derived from icosahedral ortho, meta, and para-carboranes. For comparative purpose, we include the benzoic and phthalic acids. Substitution of benzene by a carborane cage – cage effect – strikingly increases the GA for the (di)carboxylic acids, being the ortho isomers always the most acidic, following the order ortho >> meta > para. The computed GA of the dicarboxylic acid derived from ortho-carborane is far lower than sulphuric acid, due to an enhanced stabilization of the carboxylate through an intramolecular OHO bridge connection, also taking place in phthalic acid. The change of GA relative to ortho, meta and para positions of the carboxylic groups − isomer effect − is larger for carboranes. As regards to liquid-phase (MeCN), the computations show that carborane (di)carboxylic acids also show a larger acidity as compared to the phthalic acids and that the dicarboxylic ortho-carborane is also a superacid in the liquid phase (MeCN), due to the OHO bridge connection in the carboxylate, as in the gas phase. Additional computations show how much of this isomeric effect is to be attributed to the electronic delocalization.
|
2022-12-23T02:06:05.268Z
|
191,750,616 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1177/1368430219841135",
"MAG": "2947996414",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "https://kar.kent.ac.uk/74234/1/LessHumanMoreBlameREVISED2402.pdf"
}
|
Increasing economic inequality adversely affects groups with low socioeconomic status (low-SES). However, many people are opposed to wealth redistribution policies. In this context, we examined whether dehumanization of low-SES groups has a role in this opposition. In the first study (N = 303), opposition to wealth redistribution was related to denying human uniqueness (e.g., intelligence and rationality) and having negative attitudes toward low-SES groups, more than denying human nature (e.g., emotionality and capacity to suffer) to low-SES groups. Mediation analyses indicated that this effect occurred via blaming low-SES groups for their plight, after controlling for participants’ SES and negative attitudes towards low-SES groups. In the second study (N = 220), manipulating the human uniqueness of a fictitious low-SES group affected support for wealth redistribution measures through blame. These results indicate that animalizing low-SES groups reduces support for wealth redistribution via blaming low-SES groups for their situation.
|
2022-12-24T17:40:41.723Z
|
210,800,258 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1049/mnl.2018.5663",
"MAG": "2981890451",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://ietresearch.onlinelibrary.wiley.com/doi/pdfdirect/10.1049/mnl.2018.5663"
}
|
Electrical field flow fractionation (EFFF) is a particle separation method that employs an electrical field to cause particles in the carrier flow transferring in the vertical direction. The electrical characteristics of EFFF are one of the important aspects to explore electrical field how to work on the particle separation in EFFF channel. The equivalent electrical circuit model of EFFF channel was built. The experiments of chronoamperometry and electrochemical impedance spectroscopy (EIS) were conducted on the EFFF channel. The electrical circuit was utilised to fit the data of EIS experiments on EFFF channel. The fitting data were compared with the experimental data of EIS. The result indicates that the experimental data is highly quantified with the fitting data. It manifested that the equivalent electrical circuit reflected the electrical characteristics of the EFFF channel.
|
2022-05-29T21:03:35.503Z
|
115,534,108 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1049/IET-CDS.2018.5178",
"MAG": "2902608230",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
High-speed backplane connectors are extensively used in digital baseband communication circuits. Connector degradation may lead to deterioration of the integrity of digital signals and is one of the major causes of low communication quality. In this study, an accelerated test was used to produce degraded connector samples. Based on the degradation characteristics of the connector electrical contact surface, the differential transmission method was applied to enhance signal integrity in such degraded electrical contact circuits. Referring to the Gigabit Ethernet standard, the differential signal waveforms and eye diagrams of high-speed channels with un-degraded and degraded connectors were studied. Improvement of the circuit reliability by differential transmission was demonstrated from the perspectives of both experimental investigations and analysis using probability calculations.
|
2022-06-03T16:48:22.471Z
|
132,689,881 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1190/GEO2016-0155.1",
"MAG": "2551118659",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
ABSTRACTHeavy oil reservoirs are important alternative energy resources to conventional oil and gas reservoirs. However, due to the high viscosity, most production methods of heavy oil reservoirs involve thermal production. Heavy oil reservoirs’ properties change dramatically during thermal production because the viscosity drops drastically with increasing temperature. Moreover, the velocity and density also decrease after steam injection, leading to a longer traveltime of seismic velocities and low impedance of the steam chamber zone. These changes of properties can act as indicators of the steam chamber and can be detected through the time-lapse inversion method. We first establish the rock-physics relationship between oil sands’ impedance and temperature on the basis of our previous laboratory work. Then, we perform the forward modeling of the heavy oil reservoir with the steam chamber to demonstrate the influence of steam injection on seismic profiles. Then, we develop a modified-Cauchy prior-distribu...
|
2022-03-27T18:41:46.357Z
|
134,687,679 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5167/UZH-18100",
"MAG": "2795328342",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Permafrost research has a practical relevance for the construction and maintenance of infrastructure as well as for the assessment or prevention of natural hazards in cold-mountain areas. The occurrence and temperature of permafrost are largely controlled by climatic conditions
and, therefore, atmospheric warming leads to corresponding warming or thawing of permafrost in most cases. Because it is invisible at the ground surface, the delineation and
thermal characterization of permafrost largely depends on numerical models. The design and validation of such models, however, is complicated by the high spatial variability of surface properties and conditions that are characteristic of mountain areas. Three main challenges can be identified for the development of models simulating transient ground temperatures and mountain permafrost: a) to investigate and to model quantitatively, aiming for the transient
simulation of three-dimensional temperature fields; b) to investigate surface types such as bedrock or moraines and to expand knowledge on permafrost beyond coarse blocky surfaces; and c) to provide the quantitative spatial input data required by such models.
Several steps in the direction of these challenges were taken and lead to interesting results. A surface energy-balance model partly developed in this dissertation successfully simulates time series of rock surface temperatures in rugged high-mountain terrain. This was validated using the results of a systematic one-year measurement campaign of rock temperatures in the Swiss Alps. Coupled with a one-dimensional ground heat-conduction scheme this validated model was then employed to investigate the evolution and distribution of Alpine rock temperatures in steep terrain using a 22-year forward model run. This combined approach of measurements and modelling was also successful in demonstrating the degradation of permafrost during the hot summer of 2003.
A three-dimensional model of heat-transfer in rock forced with surface temperatures based on measurements and model experiments was used to investigate the effects of topography and variable surface conditions on the temperature distribution at depth. Using this approach, possibilities and caveats of the reconstruction of temperature histories from borehole temperaturedepth
profiles could be elaborated.
Straight-forward methods for the delineation of coarse blocky surfaces from aerial photography and airborne laser-scanning were developed and tested. Airborne hyperspectral data was recorded and used to fit BRDF (bidirectional reflectivity distribution function) models and to
derive albedo in rugged terrain.
Quantitative transient modelling of mountain permafrost will likely be of increasing importance for research and the assessment of natural or geotechnical hazards in the near future. The methods and results presented in this dissertation contribute to a development into this direction.
|
2022-09-14T16:05:51.243Z
|
245,875,956 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3390/nano12020195",
"MAG": null,
"PubMedCentral": "8781292"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.mdpi.com/2079-4991/12/2/195/pdf?version=1641554930"
}
|
Aluminum-doped zinc oxide film was deposited on a glass substrate by mist chemical vapor deposition method. The influence of different aluminum doping ratios on the structural and optical properties of zinc oxide film was investigated. The XRD results revealed that the diffraction peak of (101) crystal plane was the dominant peak for the deposited AZO films with the Al doping ratios increasing from 1 wt % to 3 wt %. It was found that the variation of AZO film structures was strongly dependent on the Al/Zn ratios. The intertwined nanosheet structures were obtained when Zn/O ratios were greater than Al/O ratios with the deposition temperature of 400 °C. The optical transmittance of all AZO films was greater than 80% in the visible region. The AZO film deposited with Al doping ratio of 2 wt % showed the highest photocatalytic efficiency between the wavelength of 475 nm and 700 nm, with the high first-order reaction rate of 0.004 min−1 under ultraviolet radiation. The mechanism of the AZO film influenced by aluminum doping ratio during mist chemical vapor deposition process was revealed.
|
2022-11-11T07:48:54.002Z
|
250,959,645 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3389/fnins.2022.912000",
"MAG": null,
"PubMedCentral": "9365701"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.frontiersin.org/articles/10.3389/fnins.2022.912000/pdf"
}
|
Multiple sclerosis (MS) is an autoimmune disease that causes lesions in the central nervous system of humans due to demyelinating axons. Magnetic resonance imaging (MRI) is widely used for monitoring and measuring MS lesions. Automated methods for MS lesion segmentation have usually been performed on individual MRI scans. Recently, tracking lesion activity for quantifying and monitoring MS disease progression, especially detecting new lesions, has become an important biomarker. In this study, a unique pipeline with a deep neural network that combines U-Net, attention gate, and residual learning is proposed to perform better new MS lesion segmentation using baseline and follow-up 3D FLAIR MR images. The proposed network has a similar architecture to U-Net and is formed from residual units which facilitate the training of deep networks. Networks with fewer parameters are designed with better performance through the skip connections of U-Net and residual units, which facilitate information propagation without degradation. Attention gates also learn to focus on salient features of the target structures of various sizes and shapes. The MSSEG-2 dataset was used for training and testing the proposed pipeline, and the results were compared with those of other proposed pipelines of the challenge and experts who participated in the same challenge. According to the results over the testing set, the lesion-wise F1 and dice scores were obtained as a mean of 48 and 44.30%. For the no-lesion cases, the number of tested and volume of tested lesions were obtained as a mean of 0.148 and 1.488, respectively. The proposed pipeline outperformed 22 proposed pipelines and ranked 8th in the challenge.
|
2022-12-24T17:55:49.536Z
|
223,621,282 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3760/CMA.J.ISSN.0254-1416.2010.08.041",
"MAG": "3032110385",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
二氧化碳气腹可引起血液动力学明显变化,内脏血流减少[1],血小板聚集、活化[2],虽然对机体影响短暂,但对潜在缺血或合并血栓疾病患者,气腹可诱发急性冠状动脉综合症、小肠缺血、坏死和术后深部静脉血栓形成等并发症[3-5].血栓素A2(TXA2)和前列环素(PGI2)平衡是维持血管张力和血小板正常功能的主要调节因子[6]。
|
2022-01-23T03:06:19.901Z
|
71,948,166 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1158/1538-7445.AM2012-3862",
"MAG": "2019832113",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL
Background and Aim: Liver regeneration occurs after liver damage by ischaemia, hepatitis, or in hepatocellular carcinoma (HCC) patients receiving hepatic resection or liver transplantation. Understanding the molecular bases of this process will provide novel therapeutic approaches for patients with various liver diseases. Previous studies suggested the linkage between CD44, a multifunctional cell surface receptor, and liver regeneration. The detailed role of this receptor in liver regeneration, however, remained unclear. The present study aimed at elucidating the role of CD44 in liver regeneration. Materials and Methods: A mouse model of liver regeneration induced by partial hepatectomy (PH) was employed. Serum and liver tissues were collected at different time points after PH. ELISA was performed to measure hyaluronic acid (ligand for CD44) level in serum. Flow cytometry was done to characterize liver cell populations after PH. Liver regeneration was quantified by measurement of liver mass and by immunohistochemical staining for PCNA (a proliferation marker). Quantitative PCR was performed to compare gene expression pattern of 46 genes between CD45− CD44+ cells and their CD44− counterparts. Results: Firstly, serum hyaluronic acid level was elevated at the early stage of liver regeneration. Secondly, by flow cytometry, an increase in CD45− CD44+ cell population was found. Thirdly, immunohistochemical analysis revealed active hepatocyte proliferation during this period. Interestingly, the hepatectomy-induced cell proliferation was suppressed after treating mice with anti-CD44 antibody, suggesting a functional role of CD44 in liver regeneration. Lastly, dysregulation of genes involving in cell proliferation, angiogenesis, and metabolism of hyaluronic acid was disclosed in CD45− CD44+ cells. Conclusion: The present study indicated that CD44-mediated pathways are required for liver regeneration, which may have therapeutic implications in treating liver diseases, including HCC.
Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3862. doi:1538-7445.AM2012-3862
|
2022-02-11T10:20:40.980Z
|
131,116,158 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3313/JLS1964.11.32",
"MAG": "2321829007",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
地質分類は多 くのものが提案 されかつ利用 され ている が,い ずれ の場合で も,運 動 の形式 と地質地形 の要素 あ るいは土質な どがある程度 まじ りあ った ものであ り9ど こに重点をおいたか でか な り違 ってい る。地質に重点 を おいた分類を基本 的形式 と結びつけ ることは大 きな課題 であ るが,地 すべ りの発生 は岩相 ・層相 ・岩 目**・走 向 傾斜 ・褶曲構造 ・変成度 な どの地質要素に支配 され るの で,こ れ らを充分に組合せた分類 はか な り困難な よ うで ある。一応,地 質分類 の見方 を要約す る と次の よ うであ る。 3.1 地質構造区(Geological province)に よる分類 新第三 系の分布地域 と広域変成岩 の分布地帯 とで は, そ こに発生す る地すべ りの性格がいち じる しく相違す る ことはすでに よ く知 られてい る。また,変 成岩地すべ り は原岩 の性質や変成 の特徴に よる変成帯区分 で も大 き く 違 ってい る。 とくに,三 波川変成岩帯におけ る地す べ り は分布 ・規模 ・発生機構 などい ろい ろの点で注 目されて い る。はげ しい花 崗岩化作用を伴 った領家 ・阿武隈変成 帯 な どでは割合に地すべ りが少ない。神居古潭変成帯は 蛇紋岩の貫入がいち じるしく,蛇 紋岩地すべ りな ども多 い。 広域 変成帯-と くに泥 ・砂お よび塩基 性凝 灰質 の堆 積岩をお もな源岩 とした低温高圧型 の三波川変成帯では 節理 ・片理 ・壁開の発達 した岩石が多い。破砕帯地すべ りあるいは片岩型地すべ りといわれ るのは,風 化作用に もとつ く岩石の剥離細片化が大 き要素で あ り,こ のよ う な性質を もった無点紋帯の黒色片岩や緑色片岩 の上に地 す べ り地区が大 き く発達 してい る。外 国ではほ とんどみ られない もので あ り,わ が国特有 といえ るよ うなむずか しい面 を もった地すべ りであ る。 片理(Schistosity)は 板状 ・柱状 ・針状 の造岩鉱物が」一定の方向に配 列す るた め,薄 板 を重ねた よ うな組織 とな り,岩 石が平 行に割れ やす くな った構造で ある。割れ る面を片理面 はげやす い性質を有す るものを片理性 とい う。 この組織は応力を 受けなが ら再結 晶 したために生 じた もの といわれ,広 域 変成岩にみ られ る構造で あるが,片 理は地層面 にほぼ平 行であ る場合が多い。粒状鉱物が多 くな ると弱 くな り, また変成度が進んだ岩石で も弱いが,変 成度が低い黒 色 片岩や緑色片岩 は もっ とも強 く片理があ らわれてい る。 劈開(Cleavage)は 岩石 が数cm以 下 の間隔で特定の 平行面にそ って割れ やす い性質で ある。 スレー ト劈開 ・ ち りめ んじわ劈開 ・断裂劈開が変成岩 によ く発達す る。 また鉱物が原子配列に もとついて特定 の方 向を もった 面 にそ って割れやすい性質を さし,層 状構造 をもった雲 母族 は底面 と平行に劈開 しやすい。 剥離細片化がいち じ * 通商産業省地質調査所 ** 岩 目とは節理 ・層理 ・片理な ど岩石のは く離面を総称す る 。
|
2022-06-06T12:44:55.935Z
|
109,475,658 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3141/2224-02",
"MAG": "1902372132",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A case study of the University of Washington Mailing Service, which operates a heterogeneous fleet of vehicles, provides insight into the impact of operational changes on cost, service quality, and emissions. An emissions minimization problem was formulated and solutions were identified with a creation and local search algorithm based on the I1 and 2-opts heuristics. The algorithm could be used to find many solutions that could improve existing routing on both cost and emissions metrics, reduce emissions by an average of almost 6%, and reduce costs by an average of 9%. More significant cost and emissions savings could be found with service quality reductions. For example, reducing delivery frequency to once a day could lead to emissions and cost savings of close to 35% and 3%, respectively. Rules of thumb for vehicle assignment within heterogeneous fleets were explored to gain an understanding of simple implementations, such as assigning cleaner vehicles to routes with more customers and longer travel distances. This case study identified significant emissions reductions that could be obtained with minimal effects on cost and service and that offered new, practical applications that could be used by fleet managers interested in reducing their carbon footprint.
|
2022-12-05T03:42:50.290Z
|
126,188,974 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/NSSMIC.2009.5401617",
"MAG": "2542244729",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Model fitting of PET time activity curves (TACs) is typically accomplished according to the least squares (LS) criterion, which is optimal for data with Gaussian distributed errors, but not robust in the presence of outliers (e.g., head motion). In contrast, quantile regression (QR) is an alternative for robust fitting that provides estimates not heavily influenced by outliers only losing a little efficiency, relative to LS, when no outliers are present. A data adaptive (DA) approach, relying on the rationale that QR should be used when outliers are present and LS otherwise, chooses LS or QR based solely on the observed TAC by measuring the influentiality of each TAC point and using QR when the maximum influentiality among the TAC points is higher than a given threshold. We first compare the results of applying DA to those using LS on a group of 24 healthy controls studied with [11C]-DASB to investigate whether DA improves the accuracy of parameter estimates. We also studied the application of DA to a test-retest data set of 11 controls to determine whether DA improves test-retest reproducibility. DA decreases the standard deviation (SD) of the radioligand distribution volume (V T ) (relative improvement range: 0.12% -2.59%), while keeping the within-group average V T values almost unchanged. This ~2.5% decrease in SD would result in a ~5% decrease in the number of subjects needed to maintain the same statistical power when doing group comparisons. For the test-retest data, DA reduces the V T percent difference (PD) by 0.01% - 4.39% in 63% of the regions for the majority of test-retest pairs. The practical import of this reduction in the SD and PD, achievable by simply implementing a different fitting approach, is smaller required sample size to detect differences between groups and enhanced test-retest experiments reproducibility (i.e. improved sensitivity in occupancy studies).
|
2022-12-12T07:07:39.889Z
|
2,232,850 |
{
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"ArXiv": null,
"DOI": "10.1002/dta.286",
"MAG": "2019928851",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In this work, a multiwall carbon nanotubes modified electrode (prepared by incorporating TiO(2) nanoparticles with p-aminophenol as a mediator) was used as voltammetric sensor for the determination of 6-mercaptopurine (6-MP) in the presence of uric acid (UA). The voltammograms of 6-MP and UA in a mixture can be separated from each other by differential pulse voltammetry with a potential difference of 380 mV at a scan rate of 10 mV s(-1). These conditions are sufficient to allow for the determination of 6-MP and UA both individually and simultaneously. The electrocatalytic currents increase linearly with 6-MP concentration in the ranges of 0.09-350 µmol L(-1) (two linear segments with different slopes). The detection limit for 6-MP was 0.065 µmol L(-1) . The RSD% for 1.0 and 15.0 µmol L(-1) 6-MP were 0.7%, and 1.2%, respectively. The kinetic parameters of the system were determined using electrochemical approaches. The method was successfully applied for the determination of 6-MP in drug sample, and 6-MP plus UA in urine samples.
|
2022-12-13T04:58:23.401Z
|
21,854,222 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1006/JCIS.2001.8128",
"MAG": "1966495939",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A theoretical and experimental study was performed to investigate the depletion interaction between two colloidal particles next to a solid wall in a solution of nonadsorbing macromolecules. By calculating the change in free volume available to the macromolecules upon approach of the two particles, a relatively simple expression was developed for the interparticle depletion attraction in hard sphere systems as a function of the particle-particle and particle-plate spacing. Perhaps the most useful result obtained from this analysis was that the wall has no effect whenever the ratio of the particle radius to the macromolecule radius is greater than four. (In charged systems, this ratio would apply to the effective particle and macromolecule sizes.) A series of experiments was then performed in which the hydrodynamic force balance (HFB) apparatus was used to measure the shear force needed to separate a colloidal doublet consisting of two particles trapped in a secondary energy well formed by a repulsive electrostatic force and an attractive depletion force. The macromolecules used here were small, nanometer-sized spheres of either silica or polystyrene. Agreement between the measured separation forces and those predicted using the force balance model of J. Y. Walz and A. Sharma (J. Colloid Interface Sci. 168, 485 (1994)) was within a factor of 1.3 using no adjustable parameters and accounting for polydispersity and uncertainty in the macromolecule size. It is shown that this remaining discrepancy could be caused by the Brownian (stochastic) nature of the doublet breakup process.
|
2022-12-13T10:31:37.397Z
|
22,384,318 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/TMAG.2011.2150738",
"MAG": "2171076850",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In this paper we present an improved model of the multilayered T-type electromagnetic interference chip LC filter for printed circuit board applications, and an improved measurement technique for characterization of such devices. Electrical parameters measurements of the same LC filter can vary for different measurement types. Because of that, we have developed new adaptation microstrip test fixture on printed circuit board for vector network analyzers' measurements of surface mount devices with three terminals. Two commercially available components, multilayer T-type LC filters, are measured and characterized using a vector network analyzer. The comparison of measurement data and simulation values of electrical equivalent circuit and electromagnetic model for two LC filters is further presented. The new improved model of T-type LC filters has provided better agreement between measurement and simulation.
|
2022-12-16T23:31:25.195Z
|
237,584,855 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/jcla.24008",
"MAG": null,
"PubMedCentral": "8605127"
},
"license": null,
"status": "GREEN",
"url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8605127"
}
|
Recently, measurement of serum circular RNAs (circRNAs) as a non‐invasive tumor marker has been considered more. We designed the present study to investigate the diagnostic efficiency of serum Circ‐ELP3 and Circ‐FAF1, separately and simultaneously, for diagnosis of patients with breast cancer.
|
2022-12-20T02:28:41.775Z
|
123,180,511 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1063/1.2404791",
"MAG": "2102421896",
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},
"license": null,
"status": "GREEN",
"url": "https://dr.ntu.edu.sg/bitstream/10356/90538/1/Interpolation%20of%20quaternary%20III-V%20alloy%20parameters%20with%20surface%20bowing%20estimations.pdf"
}
|
We present the weighted-sum expression of quaternary parameter estimations via balancing surface bowing estimation errors. Expressions have been derived for both quaternary alloys AxByCzD and AxB1−xCyD1−y and applied to the band gaps of AlGaInAs, AlGaInP, InAsPSb, GaInAsP, and GaInAsSb. Approximation can be improved by fitting known data of quaternary alloys and maximum deviations are less than 20meV with respect to the lattice-matched polynomial expressions.
|
2022-12-21T19:37:35.641Z
|
212,874,511 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.33720/kisgd.502426",
"MAG": "2998182705",
"PubMedCentral": null
},
"license": null,
"status": "GOLD",
"url": "https://dergipark.org.tr/tr/download/article-file/907708"
}
|
Ulkemizde yapilarda muhendislik cozumleri, 1999 yilinda gerceklesen depremden sonra ciddi bir ivme kazanmistir. Bu muhendislik disiplininin, pratik ve guvenilir olmasi her sekilde is sagligi ve guvenligi onlemleri ile baglantilidir. Is sagligi ve guvenliginin onemi yadsinamaz derecede fazladir. Ulkenin is sahasinda ki dunya konumunu, calisan personellerin egitimli olmasi ayrica teknik personelin de uretim ve guvenlik konusunda bilgi ve becerisi belirlemektedir. Ulkemizde 2012 yilinda yururluge giren 6331 sayili Is Sagligi ve Guvenligi Kanunu ile is sahalarinda saglik ve guvenlik yaptirimlari artmistir. Kanun’un getirdigi gerekliliklerin yaninda dunya literaturunde de teknik personelin yararlanabilecegi kaynak ve uygulamalar gorulmektedir. Ayrica belirtilmelidir ki dunyada ve ulkemizde bu denli hizli ilerleyen nufus artisi, yapi sektorune ragbeti arttirmaktadir. Temel kazilari, baraj, metro-tunel, tas ocaklari gibi alanlarda karsilasilan sert kayaclarda ilerleme ancak patlatmali kazi ile olabilmektedir. Patlatmalarda buluslarin 19. yuzyildan itibaren hizlanmasi muhendislik anlamda gelisimine yol acarken tehlikeli olan bu uygulamanin daha emniyetli halde yapilmasi sektorun birinci onceligi oldugu gorulmektedir. Son bolumde islenen ekip arkadaslariyla yapilan is guvenligi toplantilarinin is kazasi riskinin azaltilmasina olumlu etkisi tartisilmistir. Bu da patlatma muhendisliginde is guvenligi uygulamalarinin onemini ortaya koymaktadir.
|
2022-09-09T19:41:29.416Z
|
248,419,578 |
{
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"ACL": null,
"ArXiv": null,
"DOI": "10.1145/3491101.3516399",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
In recent years, the notion of the Metaverse has become the focus of a growing body of work in the industry. However, there is no consensus on the conceptualization in academia. To date, much of this attention has revolved around technological challenges. However, what is notably missing from these discussions is a consideration of the human factors and social aspects that are considered more critical challenges within HCI. The aims of this SIG are as follows: Firstly, to provide a platform for researchers and practitioners to engage with the various definitions and the ways in which the Metaverse is developing. Secondly, to discuss the opportunities, challenges, and future possibilities in the context of HCI. This will lay the foundations to build a network for academics interested in the field for future multidisciplinary research relating to the Metaverse.
|
2022-12-06T14:08:12.433Z
|
97,380,814 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1021/MA00100A022",
"MAG": "2086615054",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The segmental adsorption energy parameter, χ s po , was measured for poly(2-ethyl-2-oxazoline), PEOX, using a disorption/displacement technique. PEOX was desorbed from silica with five low molecular weight organic displaced in two solvents-water and ethanol-to obtain values of the critical volume fraction of the displacer at which the desorption was complete, O cr . The segmental adsorption energy for PEOX was 5.1 kT and 3.2 kT in water and ethanol, respectively. These values are consistent with the polymer adsorbing principally by hydrogen bonding between the carbonyl groups on the polymer and surface silenol groups
|
2022-08-28T01:03:52.892Z
|
9,128,705 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5194/ISPRS-ARCHIVES-XLII-2-W6-303-2017",
"MAG": "2753388286",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Abstract. The Unmanned Aerial Vehicles (UAV) and its applications are growing for both civilian and military purposes. The operability of an UAV proved that some tasks and operations can be done easily and at a good cost-efficiency ratio. Nowadays, an UAV can perform autonomous missions. It is very useful to certain UAV applications, such as meteorology, vigilance systems, agriculture, environment mapping and search and rescue operations. One of the biggest problems that an UAV faces is the possibility of collision with other objects in the flight area. To avoid this, an algorithm was developed and implemented in order to prevent UAV collision with other objects. “Sense and Avoid” algorithm was developed as a system for UAVs to avoid objects in collision course. This algorithm uses a Light Detection and Ranging (LiDAR), to detect objects facing the UAV in mid-flights. This light sensor is connected to an on-board hardware, Pixhawk’s flight controller, which interfaces its communications with another hardware: Raspberry Pi. Communications between Ground Control Station and UAV are made via Wi-Fi or cellular third or fourth generation (3G/4G). Some tests were made in order to evaluate the “Sense and Avoid” algorithm’s overall performance. These tests were done in two different environments: A 3D simulated environment and a real outdoor environment. Both modes worked successfully on a simulated 3D environment, and “Brake” mode on a real outdoor, proving its concepts.
|
2022-12-19T09:30:11.913Z
|
55,791,740 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5194/GMD-5-919-2012",
"MAG": "2118203740",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Abstract. Process-based models (PBMs) of vegetation function can be used to interpret and integrate experimental results. Water limitation to plant carbon uptake is a highly uncertain process in the context of environmental change, and many experiments have been carried out that study drought limitations to vegetation function at spatial scales from seedlings to entire canopies. What is lacking in the synthesis of these experiments is a quantitative tool incorporating a detailed mechanistic representation of the water balance that can be used to integrate and analyse experimental results at scales of both the whole-plant and the forest canopy. To fill this gap, we developed an individual tree-based model (MAESPA), largely based on combining the well-known MAESTRA and SPA ecosystem models. The model includes a hydraulically-based model of stomatal conductance, root water uptake routines, drainage, infiltration, runoff and canopy interception, as well as detailed radiation interception and leaf physiology routines from the MAESTRA model. The model can be applied both to single plants of arbitrary size and shape, as well as stands of trees. The utility of this model is demonstrated by studying the interaction between elevated [CO2] (eCa) and drought. Based on theory, this interaction is generally expected to be positive, so that plants growing in eCa should be less susceptible to drought. Experimental results, however, are varied. We apply the model to a previously published experiment on droughted cherry, and show that changes in plant parameters due to long-term growth at eCa (acclimation) may strongly affect the outcome of Ca × drought experiments. We discuss potential applications of MAESPA and some of the key uncertainties in process representation.
|
2022-12-21T09:00:29.436Z
|
211,012,413 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.1242/dmm.044024",
"MAG": null,
"PubMedCentral": "6994924"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://doi.org/10.1242/dmm.044024"
}
|
ABSTRACT First Person is a series of interviews with the first authors of a selection of papers published in Disease Models & Mechanisms (DMM), helping early-career researchers promote themselves alongside their papers. Sarah Colijn is first author on ‘Cell-specific and athero-protective roles for RIPK3 in a murine model of atherosclerosis’, published in DMM. Sarah conducted the research described in this article while a graduate student in Courtney Griffin's lab at Oklahoma Medical Research Foundation, Oklahoma City, OK, USA. She is now a Postdoctoral Research Associate in the lab of Amber Stratman at Washington University in St. Louis, School of Medicine, St. Louis, MO, USA, investigating how the cardiovascular system develops during embryogenesis in both physiological and pathological scenarios.
|
2022-03-11T09:08:39.717Z
|
9,160,235 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1152/AJPLUNG.1991.260.6.L489",
"MAG": "2402309866",
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},
"license": null,
"status": null,
"url": null
}
|
The mechanism of the accumulation of guanosine 3',5'-cyclic monophosphate (cGMP) induced by carbachol was investigated in bovine tracheal smooth muscle preparations. The effects of carbachol on cGMP were prevented with methylene blue, hemoglobin, or atropine, indicating that the increase of cGMP induced by carbachol is due to the activation of muscarinic cholinergic receptors and is mediated by the stimulation of soluble guanylyl cyclase. The elevation in cGMP induced by carbachol was also inhibited by the superoxide anion-generating compound pyrogallol (100 microM). This inhibition was reversed by superoxide dismutase (100 U/ml). Furthermore, NG-methyl-L-arginine (100 microM) and NG-nitro-L-arginine (3 microM) inhibited cGMP accumulation induced by carbachol, and this was reversed by the addition of L-arginine (1 mM). These results suggest that an endothelium-derived relaxing factor-like substance is generated in the course of carbachol-induced cGMP accumulation in bovine tracheal smooth muscle and that the precursor of this substance is L-arginine.
|
2022-09-11T10:40:22.233Z
|
209,318,554 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3390/su11236850",
"MAG": "2990666473",
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.mdpi.com/2071-1050/11/23/6850/pdf?version=1575284194"
}
|
In the context of economic globalization, the manufacturing production space in the global city-regions of developing countries have presented significant spatial characteristics, attracting attention to the problems of intensive and sustainable development of production space. Taking global city-region in the Pearl River Delta (PRD) as an example, manufacturing production space based on remote sensing (RS) technology and point of interest (POI) data extraction was more precise and continuous, which had more advantages for further analysis of spatial characteristics and influencing factors in multi-scale, and precise policy recommendations. The results show that: (1) under different scales, the distribution characteristics of manufacturing production space and the agglomeration characteristics of spatial form are different. It is not simply extensive agglomeration or diffusion that can accurately explain its diversified spatial characteristics. Meanwhile, for the local manufacturing production space optimization control, the local government should apply advanced experience according to local conditions instead of simply and roughly promotion or containment. (2) Influencing factors show a strong positive correlation with the urbanization rate, the number of foreign direct investment (FDI) enterprises and gross industrial production, and which shows a weak negative correlation with fixed asset investment and the employment population. In conclusion, the spatial characteristics of manufacturing production space in global city-regions in developing countries is significantly different from that in Western countries, and its influencing factors have similarities and differences. Therefore, when conducting multi-scale space optimization and sustainable regulation, the government should consider more about the actual multi-scale spatial characteristics of manufacturing production space and its influencing factors instead of copy the Western experience.
|
2022-12-02T10:52:53.710Z
|
207,499,504 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4155/bio.15.182",
"MAG": "2178432458",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://www.future-science.com/doi/pdf/10.4155/bio.15.182"
}
|
Applications Chemical derivatization has long proved itself as an analytical technique in bioanalysis to overcome problems associated with low ionization efficiency, compound instability, poor selectivity or unacceptable chromatographic performance (poor retention, bad peak shape and carryover issues) and even poor volatility for GC separation [1,2]. This technique is a powerful tool in many areas of chemistry including medical, forensic, food science, doping control and environmental disciplines. The goal of chemical derivatization is to modify the structure of the analyte (either a nucleophile or electrophile) using a chemical reagent (either an electrophile or nucleophile depending on the nature of the analyte) and, as a result, a new compound (the reaction’s derivate) with improved chemical and physical properties for analysis is formed. The reaction conditions (amount of the reagent, reaction time and temperature, etc) are optimized in favor of the formation of the desired derivative with the highest possible reaction yield. Additional sample clean up procedures can be developed to eliminate unwanted byproducts and excess reagents, thereby minimizing analyte inferences upon analysis. Using chemical derivatization, analysis of the impossible becomes possible. Many examples of this have been presented in the literature; impacting GC, LC–MS/MS [1–3] and NMR [4–6] detection. Most notable has been the chromatographic separation of enantiomers through chiral derivatization using specific resolving reagents without the use of specialized chiral columns and separation conditions [7–9].
|
2022-12-09T04:05:29.747Z
|
13,700,282 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1128/mBio.00625-18",
"MAG": "2801703923",
"PubMedCentral": "5941073"
},
"license": null,
"status": null,
"url": null
}
|
ABSTRACT Plasmodium vivax causes heavy burdens of disease across malarious regions worldwide. Mature P. vivax asexual and transmissive gametocyte stages occur in the blood circulation, and it is often assumed that accumulation/sequestration in tissues is not an important phase in their development. Here, we present a systematic study of P. vivax stage distributions in infected tissues of nonhuman primate (NHP) malaria models as well as in blood from human infections. In a comparative analysis of the transcriptomes of P. vivax and Plasmodium falciparum blood-stage parasites, we found a conserved cascade of stage-specific gene expression despite the greatly different gametocyte maturity times of these two species. Using this knowledge, we validated a set of conserved asexual- and gametocyte-stage markers both by quantitative real-time PCR and by antibody assays of peripheral blood samples from infected patients and NHP (Aotus sp.). Histological analyses of P. vivax parasites in organs of 13 infected NHP (Aotus and Saimiri species) demonstrated a major fraction of immature gametocytes in the parenchyma of the bone marrow, while asexual schizont forms were enriched to a somewhat lesser extent in this region of the bone marrow as well as in sinusoids of the liver. These findings suggest that the bone marrow is an important reservoir for gametocyte development and proliferation of malaria parasites. IMPORTANCE Plasmodium vivax malaria continues to cause major public health burdens worldwide. Yet, significant knowledge gaps in the basic biology and epidemiology of P. vivax malaria remain, largely due to limited available tools for research and diagnostics. Here, we present a systematic examination of tissue sequestration during P. vivax infection. Studies of nonhuman primates and malaria patients revealed enrichment of developing sexual stages (gametocytes) and mature replicative stages (schizonts) in the bone marrow and liver, relative to those present in peripheral blood. Identification of the bone marrow as a major P. vivax tissue reservoir has important implications for parasite diagnosis and treatment. Plasmodium vivax malaria continues to cause major public health burdens worldwide. Yet, significant knowledge gaps in the basic biology and epidemiology of P. vivax malaria remain, largely due to limited available tools for research and diagnostics. Here, we present a systematic examination of tissue sequestration during P. vivax infection. Studies of nonhuman primates and malaria patients revealed enrichment of developing sexual stages (gametocytes) and mature replicative stages (schizonts) in the bone marrow and liver, relative to those present in peripheral blood. Identification of the bone marrow as a major P. vivax tissue reservoir has important implications for parasite diagnosis and treatment.
|
2022-12-18T04:44:45.358Z
|
9,873,970 |
{
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"ArXiv": null,
"DOI": "10.1128/jb.133.2.925-931.1978",
"MAG": "1581666696",
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},
"license": null,
"status": "GREEN",
"url": "https://europepmc.org/articles/pmc222105?pdf=render"
}
|
Spiroplasma citri was examined by electron microscopy for morphological changes when maintained under a variety of conditions. PPLO serum fraction maintained spiral and helical morphology of S. citri at pH values of 8.0, 7.5, and 7.0, but only partially at pH 6.0 and 5.0. The absence of PPLO serum fraction resulted in round, deteriorated cells at all pH values tested. Bovine serum albumin (BSA), Phytone, soluble starch, potato starch, spermine, lipid-extracted PPLO serum fraction, and lipid-extracted BSA could substitute for PPLO serum fraction in maintaining spiral and helical morphology at pH 7.5. At pH 5.0, only BSA, lipid-extracted BSA, and lipid-extracted PPLO serum fraction were effective. Only BSA supported growth of S. citri for more than two transfers, whereas all other substitutes could not support growth longer than two transfers.
|
2022-12-23T02:18:28.579Z
|
37,691,160 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1136/jnnp.49.5.524",
"MAG": "2124269560",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://jnnp.bmj.com/content/jnnp/49/5/524.full.pdf"
}
|
Two cases of thalamic tumour, spreading through the midbrain into the pons ventrolaterally, showed suppression of cerebellar blood flow on the opposite side to the tumour, and also showed reduction of blood flow in the pons on the side of the tumour in positron emission tomographic studies. The pathophysiological mechanism of crossed cerebellar diaschisis may be due to functional suppression of the pontine nuclei by destruction of descending fibres from the cerebral cortex.
|
2022-12-23T02:20:46.238Z
|
135,844,231 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1117/12.163669",
"MAG": "2075542670",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
When gradient index rods (GI rods) were prepared by interfacial-gel copolymerization, the bulk polymerization caused serious shrinkage, which, in turn, resulted in inevitable defects. These defects in GI rods can be reduced by control of reaction conditions. Experimental results revealed that properly adjusting the reaction conditions such as concentrations of initiator, chain transfer agent, and/or temperature could reduce the viscosities of the reaction mixtures and could produce GI rods with a parabolic refractive index distribution.
|
2022-02-09T11:27:23.836Z
|
46,957,295 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.11607/ijp.2018.suppl.e",
"MAG": "2809865566",
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},
"license": null,
"status": null,
"url": null
}
|
No abstract available.
|
2022-02-11T23:17:55.448Z
|
15,444,393 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3182/20050703-6-CZ-1902.01569",
"MAG": "1217450446",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Abstract The criterion used for partitioning is d- separation : a parallel between causal independency property and vertex separation in digraphs. If X , Y and Z represent the vertex subsets of two neighbouring partition regions and respectively the border between them, the d- separation criterion is used to decide if “knowing Z renders Y irrelevant to X ”. It follows that diagnosis may be performed locally, inside each region, without communicating, via partition borders, with other regions. If borders are affected by faults, communication is needed. The described partitioning provides minimal borders between regions. It follows that communication process has minimal computational complexity.
|
2022-08-30T01:44:55.334Z
|
28,998,921 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1055/S-2007-985861",
"MAG": "2048889428",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
BACKGROUND
With neuronavigation-assistance, endoscopic neurosurgery has a variety of advantages for brain tumor resection. However, intraoperative neuronavigation has to be operated by frequently alternating a neuronavigation wand and moving the microscope back-and-forth on the surgical field while the microscope is being used for surgery, except when using stereo overlays in the operating microscope aligned to the operative scene. In our practice, our surgical endoscope was used as a sole optical device and was also calibrated as a virtual wand targeting to tumor nodules while the operation was being performed under its simultaneous visualization. This paper gives a brief description and technical report of applications of image-guided endoscopy in two cases with multiple tumor nodules.
METHODS
A 0-degree, 4-mm rigid endoscopes (DCI; Storz and Co., Tuttlingen, Germany) and Voyager SX navigation system by Z-KAT (Marconi, USA) were used for both cases, a 32-year-old woman with multiple hemangioblastomas and a 46-year-old man with two recurrent astrocytomas. The endoscope has a digital video output, which was registered with reference calibration for rendered image-guided stereoscopic views. The neuronavigation screen was formatted to provide axial, coronal, and sagittal magnetic resonance (MR) images demonstrating the location and trajectory of the endoscope's tip. Endoscope angles of 0 degrees and 30 degrees were used interchangeably during surgery. For both posterior fossa tumors, an entry point on the skull was identified using "virtual endoscopy" to visualize the intracranial anatomy and lesions.
RESULTS
A 3-cm linear skin incision for both cases was made at the entry point guided by the endoscope's video output and a 3-dimensional (3-D) rendered image on the navigation system. Three tumor nodules in the first patient, and two nodules in the second, were removed directly under navigated-endoscopic visualization on one monitor with 3D imaging-guidance images on the other side-by-side.
CONCLUSION
The neuronavigated endoscope coordinates of the tip of endoscope, and the trajectory of targets, provide both 3D orientation and direct endoscopic visualization simultaneously, and present with the unique feature for solely endoscopic minimally invasive procedures, especially for multiple intracranial lesions.
|
2022-09-13T13:08:38.224Z
|
248,049,581 |
{
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"ACL": null,
"ArXiv": null,
"DOI": "10.1177/21925682221093965",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBYNCND",
"status": "GOLD",
"url": "https://journals.sagepub.com/doi/pdf/10.1177/21925682221093965"
}
|
STUDY DESIGN
Retrospective case-control study.
OBJECTIVES
The purpose of this study is to assess whether cannabis use disorder (CUD) patients undergoing primary 1- to 2-level lumbar fusion (1-2LF) for the treatment of degenerative lumbar spine disorders have higher rates of: (1) in-hospital lengths of stay (LOS), (2) medical complications, and (3) healthcare expenditures.
MATERIALS AND METHODS
A retrospective case-control study of the MSpine dataset of the PearlDiver claims from January 2007 to March 2018 was performed. Patients with CUD undergoing 1-2LF were queried and matched to a comparison group in a 1:5 ratio by age, sex, and various medical comorbidities yielding 22, 815 patients within the study (CUD = 3805; control = 19 010). Outcomes analyzed included LOS, 90-day medical complications, and costs. A P-value less than .004 was considered significant.
RESULTS
This study found CUD patients undergoing primary 1-2LF experience longer in-hospital LOS (4- vs. 3-days, P < .0001). Additionally, CUD patients were found to have significantly higher frequency and odds-ratios (OR) (31.88 vs. 18.01% OR: 1.41, P < .0001) of adverse events within ninety days following their procedure. CUD patients also had significantly higher day of surgery ($18,946.79 vs. $15,691.02, P < .0001) and 90 days healthcare expenditures ($21,469.01 vs. $19,556.71, P < .0001).
CONCLUSION
Patients with CUD can prepare for increased LOS, complications, and costs following primary 1-2LF. The study can be used to educate these patients of the potential outcomes following their procedure.
|
2022-10-12T17:41:47.154Z
|
93,396,750 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/(SICI)1099-0518(199712)35:17<3619::AID-POLA1>3.0.CO;2-N",
"MAG": "1985880393",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
1H- and 13C-NMR techniques were used to study the microscopic structure of NMA/VP copolymer hydrogels. Evidence was obtained for a plasticization effect of MMA chains by VP. An original 1H-NMR approach revealed the existence of several types of water with various degree of bounding to the polymer network, a conclusion that is corroborated by a complementary 13C-NMR study. © 1997 John Wiley & Sons, Inc. J Polym Sci A: Polym Chem 35: 3619–3625, 1997
|
2022-12-19T08:27:45.624Z
|
26,606,130 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/08839510050119244",
"MAG": "2121983851",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This paper describes a theoretical architecture of a multiagent system that offers an integrated access to the data and knowledge that is available in local applications. By integrating the local data management activities into one transparent information distribution process, modern organizations can offer better support for its workers in the execution and coordination of their work activities. After the theoretical discussion it is shown how this architecture was implemented at a bank, and which alterations were forced on the theoretical model due to practical considerations.
|
2022-12-22T15:08:42.557Z
|
184,788,699 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.18837/RDA.V15I2.7186",
"MAG": "2519082069",
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},
"license": null,
"status": null,
"url": null
}
|
RESUMO: A questao central deste estudo e compreender em que sentido a experiencia bem-sucedida do Canada pode apresentar contribuicoes para as reflexoes e discussoes sobre formacao docente que vem sendo realizada por educadores e pesquisadores no Brasil. Destaca-se o alto nivel de resultados que o sistema educacional canadense tem alcancado em avaliacoes externas como o PISA sem abdicar de principios de uma Educacao para a cidadania. Para tanto, realizou-se uma imersao na revisao de literatura para se apresentar os sistemas de educacao canadense e o brasileiro, assim como o processo de formacao docente em cada um desses paises. Descobriu-se diferencas significativas no tocante ao departamento federal de politica educacional e ao multiculturalismo.
|
2022-01-24T23:13:24.047Z
|
100,256,318 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1152/AJPLEGACY.1942.135.3.606",
"MAG": "2599889679",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In their review of the literature concerning the plasma proteins, Madden and Whipple (1) referred to the depression of the plasma proteins which occurs in rats within twenty-four hours after partial hepatectomy, and stated, “It would be interesting to know something about blood volume at this time in these rats.” This work is concerned with the determination of blood volumes at varying periods after partial hepatectomy in the white rat. METHODS. White male rats of Wistar strain, four to six months of age, raised on a stock diet, were used. Partial hepatectomy, under ether anesthesia, was performed according to the procedure of Higgins and Anderson (2). Intact animals of the same age served as controls. After operation the animals were continued on the stock diet, and were allowed food and water ad Zibitum. Blood volume determinations were made with the dye method of Gibson and Evans (3) and Gibson and Evelyn (4), as modified for rats by Beckwith and Chanutin (5). For this procedure the animals were anesthetized with intraperitoneal sodium-pentobarbital, with precautions outlined by Sheifley and Higgins (6). In a few instances two blood volume determinations were made on the same rat at different periods after partial hepatectomy, but in most cases the animals were sacrificed after one determination. RESULTS. Data for total blood volume, plasma and red cell volumes are presented graphically in figure 1. Plasma and red cell volumes decreased comparably during the first days, and as a result none of the values for total blood volume fell within the control range during this period. Thereafter the plasma volume rose progressively, reaching the average control value on the seventh day; the individual and average values for plasma volume continued to increase appreciably and in many cases were greater than those of the control group. The majority of values for red cell volume were within the control range on the seventh day, -but the average value had not reached the control level on the twentieth day. The return of the total blood volumes to the control level about the ninth day was due principally to the increased plasma volumes. Blood volume determinations on animals subjected to simple laparotomy alone showed no devia.tion from the control range on the first and third days after operation. COMMENT. It has been observed (7) that following cessation of a moderate hemorrhage, the blood volume is quickly restored to its previous level, presum-
|
2022-06-11T21:04:30.052Z
|
21,001,767 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.1177/028418519203300415",
"MAG": "2072223797",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Plain radiographs and air enema were performed in 37 patients with ulcerative colitis, 7 patients with proctitis, and 8 patients with Crohn's disease. The air enema was superior to plain radiographs for diagnosing colitis, and for delineating the extent of disease and the degree of mucosal involvement. The air enema is simple to perform and easy to evaluate as shown by an almost complete agreement between 2 observers.
|
2022-08-27T09:09:53.699Z
|
216,438,271 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.24057/2071-9388-2019-17",
"MAG": "3015139579",
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "https://ges.rgo.ru/jour/article/download/1031/439"
}
|
The objective identification of landscape cover units is very important for sustainable environmental management planning. The article proposes a method-algorithm for describing the formation of landscape structures, which is based on the classic landscape analysis and applies the parameters of geophysical fields. The main driving forces of all structure-forming processes are the gradients of gravitational and insolation fields, parameters of which were calculated using the digital elevation models and the GIS-technologies. A minimum number of principal parameters are selected for typological and functional classification of landscapes. The number and importance of parameters were identified basing on the results of numerical experiments. Landscape classifications elaborated on the basis of standard numerical methods take a fundamental geophysical value. In this case, a concept of polystructural landscape organization is logical: by selecting different structure-forming processes and physical parameters, different classifications of landscapes could be elaborated. The models of geosystem functioning are closely related to their structure through boundary conditions and relations between parameters. All models of processes and structures are verified by field experimental data obtained under diverse environmental conditions.
|
2022-09-08T01:49:03.141Z
|
95,160,923 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/ZAAC.19865320125",
"MAG": "2030336867",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In alkalischem Medium reagiert S7NH mit Cu-Salzen unter Bildung verschiedenartiger Produkte. Mit CuCN entsteht [Cu(S3N)(CN)]−, als [Ph4As][Cu(S3N)(CN)] isoliert. Es kristallisiert monoklin, P21/c, a = 10,499(5), b = 13,418(6), c = 18,032(8) A, β = 91,84°(3), Z = 4.
Aus CuCl2 und S7NH konnen neben den bekannten Komplexionen [Cu(S3N)2]− und [Cu(S3N)Cl]− noch weitere entstehen. Unter bestimmten Bedingungen bleibt der S7N-Ring zum Teil erhalten; es bildet sich [Cu(S3N)(S7N)]−. Das schwerlosliche [(Ph3P)2N][Cu(S3N)(S7N)] kristallisiert monoklin, P21/n, a = 9,335(6), b = 30.984(11), c = 15,108(8) A, β = 102,87°(4), Z = 4.
Bei langen Reaktionszeiten entsteht aus CuCl2 und S7NH [(S3N)Cu(S2O3)Cu(S3N)]− −, bei dem die beiden Cu-Atome durch ein S-Atom eines S2O3− −-Ions verbruckt sind. Das [Ph4As]+-Salz kristallisiert triklin, P1, a = 11,226(6), b = 12,423(6), c = 19,000(10) A, α = 76,47°(4), β 83,98°(4), γ 84,71°(4), Z = 2.
In all diesen Verbindungen ist die Koordination an CuI trigonal-planar und die S3N−-Chelatgruppe in der ublichen Weise uber 2 S-Atome an Cu gebunden.
Metal Sulfur-Nitrogen Compounds. 19. Novel Complexes of CuI with the S3N− Chelate Ligand. Preparation and Structure of [Ph4As][Cu(S3N)(CN)], [(Ph3P)2N][Cu(S3N)(S7N)], and [Ph4As]2[(S3N)Cu(S2O3)Cu(S3N)]
In alkaline media S7NH reacts with Cu salts to yield different products. With Cu(CN) the ion [Cu(S3N)(CN)]− is formed, which was isolated as the [Ph4As]+ salt. The crystals are monoclinic, space group P21/c, a = 10.499(5), b = 13.418(6), c = 18.032(8) A, β = 91.84°(3), Z = 4.
Besides the known complex ions [Cu(S3N)2]− and [Cu(S3N)Cl]− still some more may be obtained when CuCl2 is reacted with S7NH: Under special conditions the S7N ring is partly preserved, and [Cu(S3N)(S7N)]− is formed. Its sparingly soluble [(Ph3P)2N]+ salt is monoclinic, space group P21/n, a = 9.335(6), b = 30.984(11), c = 15.108(8) A, β = 102.87°(4), Z = 4.
Using a longer reaction time a dinuclear complex [(S3N)Cu(S2O3)Cu(S3N)]− − results from the reaction of CuCl2 with S7NH. The two Cu atoms are bridged by an S atom of the S2O3− − anion. The [Ph4As]+ salt of the dinuclear complex anion is triclinic, space group P1, a = 11.226(6), b = 12.423(6), c = 19.000(10) A, β = 76.47°(4), β = 83.98°(4), γ = 84.71°(4), Z = 2.
In all these compounds the coordination of CuI is trigonal-planar, the S3N− chelate group coordinates the Cu in the usual way by two S atoms.
|
2022-09-11T03:29:08.431Z
|
142,624,528 |
{
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"ArXiv": null,
"DOI": "10.2307/j.ctt9qgtbc",
"MAG": "1533259780",
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},
"license": null,
"status": null,
"url": null
}
|
The division of professional and family labour An integrated conceptual approach to the daily life A new normative approach to the division of labour in society Actual evolution of the division of professional and family labour The Complete Combination Model as the basis for an integrated policy in a strong democracy Policy perspectives for the realisation of the Complete Combination Model Major results
|
2022-12-13T08:59:27.988Z
|
930,957 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1128/CVI.00340-07",
"MAG": "2125869208",
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},
"license": null,
"status": null,
"url": null
}
|
ABSTRACT The detection of antibody to the Borrelia burgdorferi C6 peptide by use of enzyme-linked immunoassays is a widely accepted method for the diagnosis of Lyme disease spirochete infection in dogs and in humans. Antibody to the C6 peptide is highly specific for B. burgdorferi and declines following treatment of dogs and humans exposed to B. burgdorferi. A quantitative assay for determining C6 antibody levels was developed and used to measure changes in antibody levels following antibiotic treatment of B. burgdorferi antibody-positive nonclinical dogs. One hundred thirty-two client-owned dogs were used in the study; 64 were negative, 53 of 68 positive animals received treatment, and 15 were untreated controls. Test sera were collected at 3, 6, and 12 months from seropositive dogs receiving treatment and untreated controls. Dogs in the treated group were assigned to moderate-to-high (≥29 U/ml)- and low (<29 U/ml)-C6-level groups because the change in the C6 level after treatment was dependent on the level prior to treatment. There were significant declines in the 30 dogs with moderate-to-high initial C6 levels that exceeded the maximal declines of the untreated control dogs in all cases at 6 months (16 data points) and 12 months (29 data points) posttreatment. There was little change in C6 level following antibiotic therapy in the 23 dogs with low initial C6 levels. The quantitative C6 antibody test can be used to measure changes in C6 antibody levels following treatment of antibody-positive nonclinical dogs.
|
2022-12-16T12:02:09.468Z
|
25,003,234 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/14660820050515403",
"MAG": "2156802797",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The classification and nomenclature of motor neuron disease, whether sporadic or familial, is confused. For example, both the sporadic and familial motor neuron diseases are phenotypically heterogeneous and, in familial ALS, phenotypic heterogeneity correlates only weakly with different underlying mutations in the SOD1 gene. We propose a classification which is based on underlying causative mechanisms, where these are known, but which also recognizes different clinical phenotypes when the cause is unknown. This classification is flexible, and allows re-attribution of clinical syndromes when their causation is understood. Currently uncertain associations – for example, a possible association of ALS with cancer – are given tentative recognition in this classification. In addition, this new classification recognizes geographical clustering and descriptions of unusual motor neuron disorder phenotypes of unknown origin in different parts of the world. (ALS 2000; 1:105–112)
|
2022-12-31T19:13:28.241Z
|
46,591,701 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1088/0967-3334/31/10/001",
"MAG": "2034712255",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Cerebral autoregulation has been studied by linear filter systems, with arterial blood pressure (ABP) as the input and cerebral blood flow velocity (CBFV—from transcranial Doppler Ultrasound) as the output. The current work extends this by using adaptive filters to investigate the dynamics of time-varying cerebral autoregulation during step-wise changes in arterial PaCO2. Cerebral autoregulation was transiently impaired in 11 normal adult volunteers, by switching inspiratory air to a CO2/air mixture (5% CO2, 30% O2 and 65% N2) for approximately 2 min and then back to the ambient air, causing step-wise changes in end-tidal CO2 (EtCO2). Simultaneously, ABP and CBFV were recorded continuously. Simulated data corresponding to the same protocol were also generated using an established physiological model, in order to refine the signal analysis methods. Autoregulation was quantified by the time-varying phase lead, estimated from the adaptive filter model. The adaptive filter was able to follow rapid changes in autoregulation, as was confirmed in the simulated data. In the recorded signals, there was a slow decrease in autoregulatory function following the step-wise increase in PaCO2 (but this did not reach a steady state within approximately 2 min of recording), with a more rapid change in autoregulation on return to normocapnia. Adaptive filter modelling was thus able to demonstrate time-varying autoregulation. It was further noted that impairment and recovery of autoregulation during transient increases in EtCO2 occur in an asymmetric manner, which should be taken into account when designing experimental protocols for the study of autoregulation.
|
2023-01-01T16:29:30.692Z
|
236,360,531 |
{
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"ACL": null,
"ArXiv": null,
"DOI": "10.18378/REBAGRO.V12I2.8886",
"MAG": "3169906020",
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},
"license": null,
"status": null,
"url": null
}
|
The omega-3 series polyunsaturated fatty acids are widely recognized as essential nutrients for humans, as they exert a variety of health benefits through their molecular, cellular and physiological action. They are considered essential for the normal growth and development of the human body, as they are not synthesized in the body, which can be supplied through the diet. Changes in the diet profile over the years have led to an imbalance between the consumption of fatty acids in the omega-6 and omega-3 series by the population. Reducing the omega-6 / omega-3 ratio would be ideal, since this imbalance is associated with several physiological diseases. A lower omega-6 / omega-3 ratio can be achieved by increasing the consumption of omega3. Considering the physiological effects attributed to these fatty acids, by enriching eggs and meat, which are the main sources of protein and indicated in healthy diets, with omega-3, they can help even more in the promotion of health. A reduction in the omega-6 / omega-3 ratio is expected in the final product intended for the consumer, a higher content of eicosapentaenoic acid and docosahexaenoic acid and an improvement in the quality of meat and eggs. This review aims to address the enrichment of meat and eggs with fatty acids of the n-3 series, as well as their benefits for human health. The consumption of food containing these substances will be in the future an alternative for both producers and consumers.
|
2022-01-27T14:35:29.912Z
|
38,639,202 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1097/MPH.0B013E318055642B",
"MAG": "2472730501",
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},
"license": null,
"status": null,
"url": null
}
|
C linicians are familiar with the statement that ‘‘common things occur commonly.’’ However, we also are aware that ‘‘all that glitters is not gold.’’ The purpose of this column is to encourage thinking outside of the proverbial box. An interesting case with accompanying radiograph, slide, or other diagnostic material will be presented for your consideration. Readers are encouraged to submit their diagnoses electronically to https// jpho.edmgr.com. Submit your diagnosis as you would any other submission. Choose ‘‘Pyrite Answer’’ for the Article Type and then attach your Word document under the Complete Manuscript (including title page, abstract, text, and references) item as you do with other submissions.
|
2022-02-28T01:05:23.878Z
|
202,700,046 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.1109/ICIMTech.2019.8843773",
"MAG": "2973686738",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The numbers of documents are increasing rapidly in a web format. Therefore, automatic document classification is needed to help human to classify the documents. Text classification is one of the common tasks in text mining problems. In order to build a model that is able to classify a document, the words are the main source as a feature to create a model. Because there are so many words in a corpus, we need to be selective which features that are significant to the labels. Feature selection has been introduced to improve the classification task. Moreover, it could be used to reduce the high dimensionality feature space. Feature selection becomes one of the most familiar solutions to high dimensionality problem of document classification. In text classification, selection of good features plays an important role. Feature selection is an approach that can be used to increase model classification accuracy and computational efficiency. This paper presents an empirical study of the most widely used feature selection methods. Term Frequency (TF), Mutual Information (MI), and Chi-square (X2) with 2 distinct classifiers Support Vector Machine (SVM) and Multinomial Naïve Bayes (MNB). The experimentations are tested out on commonly used benchmark datasets such as 20-Newsgroups, Reuters and our dataset. Because there are some parameters on how many features that we should take given that documents, we use the best 10 percent until 20 percent of features to test it out. The obtained results show that the six experiments that has been conducted Chi-squared is out as the best performance for text classification.
|
2022-07-22T06:56:23.689Z
|
16,475,078 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1097/MD.0000000000003373",
"MAG": "2346954041",
"PubMedCentral": "4863760"
},
"license": null,
"status": null,
"url": null
}
|
AbstractEpidural steroid injection (ESI) is one of the most commonly used treatments for radiculopathy. Previous studies have described the effectiveness of ESI in the management of radiculopathy. However, controversy exists regarding the route that is most beneficial and effective with respect to the administration of epidural steroids, as both transforaminal (TF) and caudal (C) routes are commonly used.This analysis reviewed studies comparing the effectiveness of TF-ESIs with that of C-ESIs in the treatment of radiculopathy as a means of providing pain relief and improving functionality. This meta-analysis was performed to guide clinical decision-making.The study was a systematic review of comparative studies.A systematic literature search was performed using the PubMed, EMBASE, and Cochrane Library databases for trials written in English. The randomized trials and observational studies that met our inclusion criteria were subsequently included. Two reviewers, respectively, extracted data and estimated the risk of bias. All statistical analyses were performed using Review Manager 5.3.Six prospective and 2 retrospective studies involving 664 patients were included. Statistical analysis was performed utilizing only the 6 prospective studies. Although slight pain and functional improvements were noted in the TF-ESI groups compared with the C-ESI groups, these improvements were neither clinically nor statistically significant.The limitations of this meta-analysis resulted primarily from the weaknesses of the comparative studies and the relative paucity of patients included in each study.Both the TF and C approaches are effective in reducing pain and improving functional scores, and they demonstrated similar efficacies in the management of lumbosacral radicular pain.
|
2022-11-17T02:23:16.132Z
|
14,015,573 |
{
"externalids": {
"ACL": null,
"ArXiv": "1606.04914",
"DOI": "10.1063/1.4955401",
"MAG": "3101563643",
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "https://aip.scitation.org/doi/pdf/10.1063/1.4955401"
}
|
In semiconductors almost all heat is conducted by phonons (lattice vibrations), which is limited by their quasi-particle lifetimes. Phonon-phonon interactions represent scattering mechanisms that produce thermal resistance. In thermoelectric materials, this resistance due to anharmonicity should be maximised for optimal performance. We use a first-principles lattice-dynamics approach to explore the changes in lattice dynamics across an isostructural series where the average atomic mass is conserved: ZnS to CuGaS$_2$ to Cu$_2$ZnGeS$_4$. Our results demonstrate an enhancement of phonon interactions in the multernary materials, and confirm that lattice thermal conductivity can be controlled independently of the average mass and local coordination environments.
|
2022-12-16T15:37:47.321Z
|
53,334,758 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1142/S0219024908005056",
"MAG": "2254448215",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This article derives a series of analytic formulae for various contingent claims under the real-world probability measure using the stylised minimal market model (SMMM). This model provides realistic dynamics for the growth optimal portfolio (GOP) as a well-diversified equity index. It captures both leptokurtic returns with correct tail properties and the leverage effect. Under the SMMM, the discounted GOP takes the form of a time-transformed squared Bessel process of dimension four. From this property, one finds that the SMMM possesses a special and interesting relationship to non-central chi-square random variables with zero degrees of freedom. The analytic formulae derived under the SMMM include options on the GOP, options on exchange prices and options on zero-coupon bonds. For options on zero-coupon bonds, analytic prices facilitate efficient calculation of interest rate caps and floors.
|
2023-01-01T19:40:23.600Z
|
198,639,784 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1177/0843871419842053",
"MAG": "2955950095",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In the too-hidden history of black and minority ethnic (BAME) seafaring, the story of First World War internees is a lost one. But now black seamen’s experiences as detainees at Ruhleben camp in Germany has been somewhat revealed by this new exhibition. In peacetime, happy crowds had jaunted 10 km west from central Berlin by way of the Tiergarten and Charlottenberg suburbs to turn down a suburban lane near Spandau and enjoy watching horses harnessed to sulkies race each other at this track by the River Spree. But from November 1914 to November 1918 the people heading for the racecourse went there under duress and armed guard: British interned civilians, there for the duration of the war, if they did not escape. Now spectators, including many captured seafarers, far from home watched their comrades perform Lady Windermere’s Fan and play cricket. And yes, in these barracks (see Figure 1) they still gambled. Seafarers were around two-thirds of the BAME people in the camp. BAME men were roughly one in 15 of the 5,500 (at peak) detainees there. Britons included intellectuals who had been holidaying in Germany, seafarers working on German ships, (see Figure 2) and stranded business men. Poignant photographs in Grant’s new exhibition represent the lives of the 300 British civilian subjects who happened to be black and in Germany at the outbreak of war. Many seafarers of every background were aboard colliers, fishing trawlers and cargo ships impounded on 4 August 1914 at Hamburg, Bremerhaven and Bremen: the Banana, Dartwen, Indianola, May Scott, Nicoya, Oron, Pandosia, Rossall, Sangara, Treglisson, Treneglos and West Quarter. Merchant seafarers from Sierra Leone/ Liverpool and the Yemen/South Shields, mainly firemen and trimmers, were with their shipmates from Hull, Grimsby and Boston. Others among them were from further afield, such as Barbadian William Savory (51), working on the minute Grimsby trawler FV Seti, which was captured in the North Sea on 26 August 1914 by torpedo boat V 154. More
|
2022-02-08T06:06:33.956Z
|
136,220,337 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.7498/aps.38.1869",
"MAG": "2620758237",
"PubMedCentral": null
},
"license": "CCBY",
"status": "HYBRID",
"url": "https://doi.org/10.7498/aps.38.1869"
}
|
We report the experimental set-up and measurement system combining with a fast-scan Fourier transform spectrometer for photothermal ionization spectroscopy. They have been successfully applied for the investigation and detection of residual shallow impurity centers in ultra-pure germanium and silicon single crystals with high resolution as well as high sensitivity. Boron acceptor at a concentration of the order of magnitude of 10 8 cm -3 has been detected in ultra-pure germanium, and the detection limit of at least 10 7 cm -3 has been demonstrated. Lithiumoxygen donor complex D(Li, O) has been revealed in n-type highpurity silicon. Transition line series of both boron acceptor and phosphorus donor in p-type high-purity silicon have been observed simultaneously with the excitation of intrinsic light. In addition, the transitions associated with higher excited states of shallow impurities in both germanium and silicon have also been observed.
|
2022-02-09T11:15:14.087Z
|
45,350,649 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/PICMET.2009.5262277",
"MAG": "2106261982",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The author believes that developing countries (DC), in particular Iran, need to urgently develop a culturally appropriate national strategy if they wish information technology (IT) to have a positive impact on their overall socio-economic development. While countries like Singapore claim to have very successful national strategies, the long-term impact on the country's social development may have been over looked. Left unchecked the technological marketplace will impose a hard-to-reverse negative role on small countries like Iran. This will make it increasingly difficult for Iran to decide its is own long-term preferences for social and economic development. Put bluntly, these countries need to decide what they want from the global technology marketplace and then work out how they are going to achieve it. It is believed that hard technological determinism can only be countered by very real and well thought out national strategies. The paper argues that the national IT strategy will need to address the issues of resistance to change due to cultural, personal and infrastructure factors, be very culturally sensitive and given the rate change of the technology, will need to be constructed as an evolving, and learning system. The first stage in the development of such a system is to design an appropriate forum for discussion, and a well-constituted and ongoing decision-making protocol. It seems appropriate that in countries with a less than thriving technology marketplace, it is incumbent on their Government to provide a lead in this complex undertaking.
|
2022-03-03T23:24:28.277Z
|
248,253,712 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.26522/tg.v7i1.3639",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBYNCND",
"status": "GOLD",
"url": "https://journals.library.brocku.ca/index.php/bujh/article/download/3639/2980"
}
|
Based on the primary source “The Passion of SS. Perpetua and Felicitas,” this paper aims to explore the relationship between the physical and spiritual realms in the early Christian mindset. The account of Perpetua—a third-century Christian martyr—offers insight into religious persecution in the Roman Empire prior to the decriminalization of Christianity by Emperor Constantine in the fourth century. Many physical and spiritual elements are included as the account describes Perpetua’s conversion, her imprisonment, and supernatural visions. Two of Perpetua’s visions are analysed in this context in an effort to more fully understand the early Christian perception of the fluidity between heaven and earth. Not only do spiritual beliefs have observable implications in the temporal world, but physical objects and experiences are present in the spiritual realm as well.
|
2022-07-04T09:27:49.077Z
|
169,432,268 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.25126/JTIIK.2018551113",
"MAG": "2898837451",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Kecelakaan lalu lintas di jalan raya masih menjadi penyumbang tingginya angka kematian di Indonesia, sehingga menjadi perhatian khusus bagi kepolisian di negara ini. Termasuk Kepolisian Resor (Polres) Tanah Laut, yang telah membuktikan perhatian tersebut dengan membentuk komunitas korban kecelakaan lalu lintas dan Pelatihan Pertolongan Pertama Gawat Darurat (PPGD). Tahapan awal pencegahan kecelakaan lalu lintas adalah dengan mengetahui faktor-faktor penyebab kecelakaan lalu lintas yang diperoleh melalui analisa data kecelakaan. Analisa tersebut dapat dilakukan dengan data mining, yaitu K-Means Clustering. K-Means Clustering mengelompokkan data menjadi beberapa cluster sesuai karakteristik data tersebut. Data kecelakaan lalu lintas dibagi menjadi 2 dataset, yakni dataset 1 dan dataset 2. Hasil cluster penerapan K-means clustering terhadap dataset 1 dan dataset 2 kemudian dilakukan pengujian silhoutte coefficient untuk mencari hasil cluster dengan kualitas terbaik. Pengujian silhoutte coefficient secara berurutan menghasilkan distance measure paling optimal yakni clustering dengan 4 cluster untuk dataset 1 dan clustering dengan 2 cluster untuk dataset 2. Selain memperoleh cluster dengan kualitas terbaik, penganalisaan data juga menghasilkan beberapa informasi kecelakaan lalu lintas yang sering terjadi, yakni faktor penyebab dan korban kecelakaan adalah pengemudi, umur korban adalah 9 sampai 28 tahun, dan keadaan korban kecelakaan adalah luka ringan. AbstractTraffic accidents on the highway are still contribute to the high mortality rate in Indonesia, which are becoming a special concern for the police. Including the Police of Tanah Laut Resort where prove themselves by established The Community of Traffic Accident Victims and Emergency First Aid Training. The first prevention of traffic accidents is knowing the factors causing traffic accidents which is obtained through the analysis of traffic accident’s data. It can be done through data mining, i.e. K-Means Clustering, which is clustering data into clusters according to characteristics of the data. Traffic accident data is divided into two datasets, namely dataset 1 and dataset 2. After obtaining the cluster results, the next step is to calculate silhoutte coefficient which is used to find the best quality cluster result. The result of testing silhoutte coefficient are clustering with 4 clusters for dataset 1 and clustering with 2 clusters for dataset 2. Analyzing data in this research also produces some information on traffic accidents that often occur, namely the causes and victims of accidents are drivers, the age of the victims is between 9 and 28 years old, and the circumstance of the accidents victims are minor injuries.
|
2022-08-20T13:35:38.639Z
|
240,244,425 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3390/met11111722",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.mdpi.com/2075-4701/11/11/1722/pdf?version=1635416142"
}
|
A novel grain refinement method using a CaMgSn intermetallic phase was investigated via adding a Mg–CaMgSn master alloy to an AZ31 magnesium alloy. The results showed a remarkable grain refinement effect in as-cast AZ31, with the average grain size reduced from approximately 260–93 μm after adding 0.45 wt.% CaMgSn particles. The added CaMgSn phase was found in grain interiors and acted as heterogeneous nucleation sites during solidification. The edge-to-edge matching model confirmed a low mismatch value of 2.3% for the {0002}Mg/{211}CaMgSn close-packed plane, suggesting that {211}CaMgSn was the possible matching plane for Mg nucleation. The microhardness and compressive yield strength were also improved by adding CaMgSn particles, confirming that adding Mg–CaMgSn master alloy was an effective method for refining the microstructure and improving the mechanical properties of Mg–Al-based alloys.
|
2022-11-04T01:05:31.506Z
|
86,313,682 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1093/JXB/43.12.1611",
"MAG": "2171731028",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
6-benzylaminopurine (BAP) delays leaf abscission of soybean Glycine max (L.) Merr. Abscission of the distal pulvinus of primary leaves was induced in 12-d-old seedlings or explants by removal of the leaf blade. BAP applied to the cut end of the pulvinus following leaf blade removal delayed abscission. Discoloration of the pulvinus occurred before abscission commenced and the number of grana in chloroplasts within cortical parenchyma cells of the pulvinus decreased over time following leaf blade removal
|
2022-12-09T20:51:16.190Z
|
17,099,289 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1155/2012/589359",
"MAG": "2129025664",
"PubMedCentral": "3465901"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://doi.org/10.1155/2012/589359"
}
|
The occurrence of nephritis in patients with systemic lupus erythematosus is associated with increased morbidity and mortality. The pathogenesis of lupus nephritis is complex, involving innate and adaptive cellular and humoral immune responses. Autoantibodies in particular have been shown to be critical in the initiation and progression of renal injury, via interactions with both Fc-receptors and complement. One approach in the management of patients with lupus nephritis has been the use of intravenous immunoglobulin. This therapy has shown benefit in the setting of many forms of autoantibody-mediated injury; however, the mechanisms of efficacy are not fully understood. In this paper, the data supporting the use of immunoglobulin therapy in lupus nephritis will be evaluated. In addition, the potential mechanisms of action will be discussed with respect to the known involvement of complement and Fc-receptors in the kidney parenchyma. Results are provocative and warrant additional clinical trials.
|
2022-12-13T01:11:05.192Z
|
110,799,910 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.12989/WAS.2007.10.5.401",
"MAG": "2041094801",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Field measurements of the wind-induced response of two residential reinforced concrete buildings, among the tallest in the world, have been performed during two typhoons. Natural periods and damping values have been determined and compared with other field measurements and empirical predictors. Suitable and common empirical predictors of natural period and structural damping have been obtained that describe the trend of tall, reinforced concrete buildings whose structural vibrations have been measured in the collection of studies in Hong Kong compiled by the authors. This data is especially important as the amount of information known about the dynamic parameters of buildings of these heights is limited. Effects of the variation of the natural period and damping values on the alongwind response of a tall building for serviceability-level wind conditions have been profiled using the gust response factor approach. When using this approach on these two buildings, the often overestimated natural periods and structural damping values suggested by empirical predictors tended to offset each other. Gust response factors calculated using the natural periods and structural damping values measured in the field were smaller than if calculated using design-stage values.
|
2022-12-16T09:45:01.050Z
|
85,869,550 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.21273/HORTSCI.43.1.271",
"MAG": "2161523072",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This investigation determined the effects of exogenous ATP supply on the senescence-related physiology of cut carnation flowers. With a view to understanding better the role of tissue energy status in the senescence of carnation flowers, the effects of exogenous ATP supply on time to maximum flower expansion, vase life, rates of ethylene production and respiration, and endogenous ATP and adenosine monophosphate (AMP) concentrations during vase life of cut carnation flowers were investigated. Carnation cv. ‘Master’ flowers were obtained from a commercial market in Guangzhou, China. Flowers were transported to the laboratory within 6 h. Flowers were uniform at commercial maturity (outer petals horizontal), as described by Wu et al. (1992). Their stems were recut under water to a length of (cid:2) 30 cm. Stems were assigned at random to flasks containing either distilled water (con-trol) or 0.1 mmol (cid:3) L –1 ATP solution until the end of the vase life of the control flowers (up to 10 d). The concentration of 0.1 mmol (cid:3) L –1 ATP is the most beneficial in extending the vase life of the cut flowers, as identified by Song et al. (2006b). The volume of ATP solu- tion or distilled water was maintained at con-stant levels by replenishing the flasks daily. There were four flowers per flask and three flasks (replications) per treatment. Flasks were arranged in a completely randomized design. Throughout the experimental period, flowers were held at 25 (cid:2) C and 70% to 80% relative humidity with a 12-hour light period per day at an irradiance of 12 W/m 2 at flower level from fluorescent light tubes. The time (d) from harvest to the maximum flower expansion was calculated. Vase life was evaluated every 12 h on a scale from 1 to 5 pt as described by Song et al. (2006b), where 1 pt is fresh without any deterioration;
|
2022-12-23T02:17:46.563Z
|
97,556,011 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/ELAN.1140010403",
"MAG": "2074621850",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
An enzyme-amplified, two-site immunoassay utilizing electrochemical detection has been developed for thyrotropin. The lower detection limit of the assay (mean plus 2 standard deviations of the zero standard) is 0.046 ml. U/L, and the precision is good, giving a working range of 0.2 to 18.5 ml. U/L (determined as a percentage dose CV < 10). The assay of a 25 μL serum sample in an eight-well microtitre strip takes approximately 1 hour. The electrochemical detection is carried out in situ using a custom-built electrode array comprising eight graphite indicator electrodes and eight stainless-steel cathodes. This arrangement, together with a fast multiplexer, allows the quasisimultaneous measurement of eight samples. A good correlation between this method and a radioimmunometric assay (IRMA) procedure was obtained for the determination of thyroid-stimulating hormone (TSH) in patient samples. The relevant properties of a novel graphite material developed for this work are described.
|
2022-02-10T13:25:52.844Z
|
7,720,647 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1021/jp409132e",
"MAG": "1964223854",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The fluorescence spectrum of CdSe core-CdS/ZnS shell colloidal quantum dots (QDs) embedded in porous alumina membrane was studied. Small peaks, superimposed on the principal QD fluorescence spectrum, were observed. Finite-difference time-domain simulation indicates that the QD point radiation emitting from within the membrane is strongly modulated by the photonic band structure introduced by the membrane pores, leading to the observed fine spectral features. Moreover, the principal QD fluorescence peak red-shifted when the optical excitation power was increased, which is attributed to QD material heating due to emitted phonons when the photoexcited electron and hole relax nonradiatively from high-energy states to the ground exciton state before fluorescence.
|
2022-07-23T02:44:30.089Z
|
154,621,438 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/01402390008437776",
"MAG": "2125582980",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
US policymakers and analysts are increasingly pre-occupied by the problem of nuclear proliferation, once considered, in the parlance of the Pentagon, to be a 'lesser included threat' covered by the nuclear policies of the United States and its allies. Several factors, probably the least of which was the 1995 Nuclear Non-Proliferation Treaty Review Conference, have sparked this interest. The end of the Soviet empire has highlighted the potential proliferation of nuclear technology, materials, expertise and even weapons as a superpower-sized nuclear infrastructure is divided among several states, including some that are hard pressed to safeguard a nuclear arsenal or materials.' The concerted efforts of several nations Iraq, Iran and North Korea to acquire nuclear weapons serves as a continuous reminder of the dangers of proliferation. The confrontation between Baghdad and the UN Special Commission repeatedly threatened to end in war, while the termination of UN inspections marked the complete militarization of the US effort to contain Iraq's nuclear ambitions. Doubts also linger about whether or not the 1994 Agreed Framework has contained North Korea's nuclear program. The May 1998 series of Indian and Pakistani nuclear tests suggests that both states are determined to deploy modest nuclear arsenals, thereby adding the prospect of a nuclear arms race to their already troubled relations.
|
2022-08-27T11:45:31.598Z
|
233,567,595 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1049/RSN2.12043",
"MAG": "3137743293",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
National Science Foundation, Grant/Award Number: #AST‐ 1547420 Abstract A signal embedding scheme into the emission of multiple‐input multiple‐output (MIMO) frequency hopping (FH) radar is analysed. In this scheme, the phase shift keying (PSK) communication symbols are multiplied with the frequency hops in fast‐time, resulting in dual‐function radar‐communication (DFRC) waveforms. The authors examine the impact of PSK symbol embedding on the ambiguity function (AF) and power spectral density (PSD) and show that modulation of the radar pulse can benefit the radar functionality. The effect of PSK symbol embedding on the radar target detection performance of the DFRC system is delineated. The authors’ analyses show that the use of the DFRC waveforms enhances target detection performance. The authors also provide the symbol error rates (SERs) corresponding to different phase constellations at the communication receiver and address the practical data transfer rates that can be achieved with the underlying embedding scheme.
|
2022-10-07T00:54:33.911Z
|
253,064,220 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1088/1741-2552/ac9c97",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Objective. Critical slowing features (variance and autocorrelation) of long-term continuous electroencephalography (EEG) and electrocardiography (ECG) data have previously been used to forecast epileptic seizure onset. This study tested the feasibility of forecasting non-epileptic seizures using the same methods. In doing so, we examined if long-term cycles of brain and cardiac activity are present in clinical physiological recordings of psychogenic non-epileptic seizures (PNES). Approach. Retrospectively accessed ambulatory EEG and ECG data from 15 patients with non-epileptic seizures and no background of epilepsy were used for developing the forecasting system. The median period of recordings was 161 h, with a median of 7 non-epileptic seizures per patient. The phases of different cycles (5 min, 1 h, 6 h, 12 h, 24 h) of EEG and RR interval (RRI) critical slowing features were investigated. Forecasters were generated using combinations of the variance and autocorrelation of both EEG and the RRI of the ECG at each of the aforementioned cycle lengths. Optimal forecasters were selected as those with the highest area under the receiver-operator curve (AUC). Main results. It was found that PNES events occurred in the rising phases of EEG feature cycles of 12 and 24 h in duration at a rate significantly above chance. We demonstrated that the proposed forecasters achieved performance significantly better than chance in 8/15 of patients, and the mean AUC of the best forecaster across patients was 0.79. Significance. To our knowledge, this is the first study to retrospectively forecast non-epileptic seizures using both EEG and ECG data. The significance of EEG in the forecasting models suggests that cyclic EEG features of non-epileptic seizures exist. This study opens the potential of seizure forecasting beyond epilepsy, into other disorders of episodic loss of consciousness or dissociation.
|
2022-11-04T20:46:25.829Z
|
235,359,626 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/jcmm.16695",
"MAG": null,
"PubMedCentral": "8278109"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jcmm.16695"
}
|
Melanoma is a kind of skin cancer that is begun by the alteration of melanocytes. miRNAs are small non‐coding RNA molecules that regulate a variety of biological processes. KISS1, the metastasis‐suppressor gene, encodes kisspeptins which inhibits migration and proliferation of cancers. This study was aimed to determine the role of Let‐7i and KISS1 in melanoma cell migration and proliferation. At first, the expression of Let‐7i and KISS1 was determined in patients with melanoma. In the in vitro part of the study, Let‐7i mimics were transfected and the impact of its restoration on target gene expression, proliferation, migration and apoptosis of SK‐MEL‐3 melanoma cell line was assessed by real‐time PCR and Western blotting, MTT assay, wound‐healing assay and flow cytometry, respectively. Besides, KISS1 inhibitor siRNA alone and along with Let‐7i was transfected to determine their probable correlation. The results revealed that either Let‐7i or KISS1 were down‐regulated in patients with melanoma. The results obtained from the in vitro part of the study revealed that restoration of Let‐7i reduced the expression of metastasis‐ and proliferation‐related target genes. Moreover, it was revealed that up‐regulation of Let‐7i attenuated migration and proliferation capability of SK‐MEL‐3 cells. Besides, it was demonstrated that Let‐7i restoration induced apoptosis in melanoma cells. More importantly, the KISS1 inhibitor caused a prominent cell migration and proliferation, attenuated by Let‐7i re‐expression. To sum up, the present study revealed the impressive role of Let‐7i restoration along with its correlation with KISS1 on melanoma carcinogenicity which may be applicable in future in vivo studies.
|
2022-12-10T08:55:33.576Z
|
30,036,042 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1210/ENDO-88-6-1349",
"MAG": "2022050554",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Intravenous injection of ovine prolactin (1 mg/kg) into normal dogs resulted during the first hour in a transient decrease in the plasma free fatty acid (FFA) concentration, which was followed by a significant increase by the third hour and thereafter. The effect of prolactin injection (2 mg/kg) on the preceding day on FFA turnover and oxidation in the postabsorptive state was determined in unanesthetized normal dogs by the intravenous infusion of 14C-palmitate. The elevated plasma FFA levels were associated with an increased rate of FFA production and removal from the plasma. The amount of plasma FFA carbon which was oxidized rapidly to respiratory CO2, as determined by the exhaled 14CO2, was increased in the prolactin- treated dogs, but there was no change in the percentage of the FFA carbon taken up which was oxidized to CO2. (Endocrinology 88: 1349,1971)
|
2022-12-12T10:56:47.421Z
|
25,195,451 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/J.1365-2788.2006.00775.X",
"MAG": "2017348820",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
BACKGROUND
Although there has been considerable research into the genotype and phenotype of Williams syndrome, there have been relatively few studies of long-term prognosis. As a preliminary to a more detailed investigation of adults with Williams syndrome, a parental questionnaire was distributed to members of the UK Williams Syndrome Foundation, focusing on areas of skill and difficulties in adult life.
METHOD
A postal questionnaire was distributed to all members of the UK Williams Syndrome Foundation who had a son or daughter aged 18 years or over. The questionnaire covered issues related to the physical and mental health of the adults with Williams syndrome, together with questions about educational and employment status, self-help and independence skills.
RESULTS
Out of a total of 290 questionnaires distributed, 239 were returned (82% response rate). The data highlighted the continuing high rates of physical problems in this group and apparent increases in rates of mental health problems with age. Parents also expressed their concerns about the lack of adequate support and care. Educational and employment attainments were generally low and self-help skills were relatively poor.
DISCUSSION
The findings highlight the need for far better understanding of conditions such as Williams syndrome among professionals working in adult services and the need for more adequate support from educational, health and social services.
|
2022-12-19T22:48:31.536Z
|
245,743,833 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.17775/cseejpes.2020.04070",
"MAG": "3212449910",
"PubMedCentral": null
},
"license": "CCBYNCND",
"status": "GOLD",
"url": "https://doi.org/10.17775/cseejpes.2020.04070"
}
|
Contactless slipring (CS) system utilizing inductive-power-transfer (IPT) technology is a good candidate for the traditional mechanical slipring assemblies. However, suffering from the high harmonic currents in strong coupling CS system, the output power will deviate from the theoretical values estimated by the fundamental harmonic approximation (FHA) and its extension method, i.e., E-FHA, in which the power are transferred by both the fundamental current and the high order harmonic currents. In order to achieve high precise output estimation, a unified analysis is proposed in this paper. Firstly, "Fundamental-harmonic Double Resonance Phenomenon" is revealed via impedance analysis, to address the nature of the high harmonic currents in strong coupling system. Then, a unified output current expression owning high precision is derived, followed by a unified fundamental load impedance. Discussions show that both the output and the fundamental load impedance of FHA, and E-FHA are all the special cases of the unified expressions proposed. FHA, and E-FHA are precise enough for the loose coupling system, whereas the proposed method is indispensable for the strong coupling system with k>0.4. Finally, simulations and experimental measurements of a 1.6kW CS system, as well as the comparative studies among FHA, E-FHA, and the proposed method, are presented, indicating that the proposed method are effective for high precise output estimation.
|
2022-01-27T09:21:28.074Z
|
57,378,979 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/ICIRCA.2018.8597342",
"MAG": "2909274332",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Since every mobile device is owned primarily by an individual person, it is possible to have a customized recognizer that well matches the qualities of that particular user. In personalisation of language models the need of much huge corpora(database) and massive amount of errors in the previous technologies makes them outdated and also they show poor performance during their execution. The previous technologies includes N gram based language model and recurrent neural network language model(RNNLM). Although projects on acoustic model personalisation has undergone lot of research over many years, but much less work has been reported on linguistic model personalisation. The primary section is the speaker recognition, which is done using MFCC(Mel frequency cepstrual coefficient processor). In the secondary section we will convert the speech input to text with predictive actions, like when we give a voice input to the system it will detect the word and convert it into the personalized text. This is called personalized, because the neural network were trained with the database of the specific user who is supposed to use the the system individually. For this, the data base will be created first with his personal slang. There might be grammatical errors posed by the individual user whilst training the neural network, however the same shall be used to create the database without correction along with other common words used by the individual user, so that it can generate the personalized language while he is talking to the system. Also it will display the next word prediction and the same will be taken from the personalized database. During the work of this thesis, we tend to propose improved customized model by using deep belief network. Here the deep belief network (DBN) shows higher performance than the N gram based models, recurrent neural network and conventional neural network technologies. Presumptively the deep belief network needs only less corpora and shows higher end in word error rate and running time. Also it is possible to have multiple word prediction with more accuracy using deep belief network, whereas with recurrent neural network it is possible only to have single prediction.
|
2022-07-07T11:15:43.138Z
|
142,662,612 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2307/4065824",
"MAG": "1518997699",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Language is a powerful tool in shaping and entrenching power relations in society. Hajira Vahed argues for the need to challenge its use both in society and the classroom
|
2022-09-01T22:06:48.838Z
|
193,944,997 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.17851/2317-2096.11.0.115-125",
"MAG": "1499258831",
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},
"license": "CCBY",
"status": "GOLD",
"url": "https://doi.org/10.17851/2317-2096.11.0.115-125"
}
|
O presente ensaio analisa a obra de Andrei Tarkovski, tomando como ponto de partida as relacoes entre seus filmes e seus escritos teoricos. Ao mesmo tempo, discutindo o lugar que o diretor ocupa no cinema moderno, pretende-se mostrar como Tarkovski se distancia daquilo que Martin Jay chamou de “discurso anti-ocularcentrico”.
|
2022-11-11T08:07:36.040Z
|