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255M
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85,141,343 |
{
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"DOI": "10.2503/JJSHS.64.611",
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|
To use RAPD method for the identification of evergreen azalea cultivars, the optimum method for DNA extraction in Rhododendron spp. was investigated. Of almost all Rhododendron species native to Japan and some cultivar groups, neither SDS nor CTAB method was sufficient to isolate clean DNA from leaves. But, by using the modified CTAB method after Greenwood et al. (1989), we obtained a good yield of high quality DNA from the materials used in this experiment. Using the optimum extraction method mentioned above and RAPD analysis, differences among azalea cultivars could be distinguished. Sixteen out of 100 primers tested produced obvious, definitive polymorphic DNA bands. Cultivars in the Edo-Kirishima group (9 cultivars) or Kurume azalea group (14 cultivars) were clearly recognized from one another by using primer OPK-19 or OPK-20. In the Satsuki group, these two primers could be used to discern 'Kouzan' from its bud sport cultivars. The results of this study strongly suggest that RAPD method is a very useful tool for cultivar identification in evergreen azalea.
|
2023-01-01T15:37:51.775Z
|
222,231,639 |
{
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"ArXiv": null,
"DOI": "10.1117/12.2573698",
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|
Linear Astigmatism Free - Three Mirror System (LAF-TMS) is a confocal off-axis system that eliminates linear astigmatism, which is the most critical aberration especially in the large field angle, and therefore, enables the telescope to have a wide field of view. Based on our experience with the telescope, we optimized the LAF-TMS for wavelength ranges of mid-wavelength infrared (3-5 µm) and long-wavelength infrared (8-12 µm) sensors onboard Unmanned Aerial Vehicles (UAVs). It has an entrance pupil diameter of 70 mm, a focal ratio of 1.4, and a wide field of view (FoV) of 6.20° × 4.68°, matching 10.9 mm × 8.2 mm sensor with 17 µ m sized pixels (LAF-TMS D70F1.4). The freeform mirrors of LAF- TMS D70F1.4 are optimized to eliminate the high order aberration. As a result, LAF-TMS D70F1.4 can achieve high- quality optical performance over a wide FoV without any additional correcting lenses. We performed the sensitivity analysis and the Monte-Carlo simulations as the feasibility study. During the sensitivity analysis and the Monte-Carlo simulation, decenter, tilt, despace, and surface RMS errors of three mirrors were analyzed. From the sensitivity analysis, we investigated 80% Energy Encircled Diameter by single factor perturbations. The system tolerance limits were calculated using the Monte-Carlo method with a normal distribution of errors. According to the results, we confirmed that the LAF-TMS D70F1.4 was feasible considering general fabrication and alignment tolerances.
|
2022-02-08T00:58:04.395Z
|
82,849,620 |
{
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"ArXiv": null,
"DOI": "10.25110/ARQSAUDE.V2I3.1998.932",
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|
A vagina possui flora bacteriana natural abundante, composta de uma mistura de microorganismos aerobios e anaerobios que podem causar inflamacao. Embora muitos destes microorganismos sejam considerados patogenos, sua mera presenca nao indica necessariamente infeccao. Apesar da inquestionavel importância diagnostica da colpocitologia na deteccao de bacterias da flora vaginal normal ou disturbios desta, escassas sao as referencias completas sobre este tema, fatos estes que motivaram a realizacao de uma revisao na literatura sobre as bacterias do trato genital feminino que podem ser detectadas pela citologia. Tal revisao copreende: bacterias aerobias-lactobacilos, cocos gram positivos e negativos, coliformes e bacilos difteroides; e bacterias anaerobias- Gardnerella vaginalis, Mobiluncus sp., Actinomyces sp., Fusobacterium sp. e Leptothrix vaginalis. Discute-se ainda a aplicacao dos termos vaginites e vaginoses bacterianas. Conclue-se com o presente trabalho que o conhecimento das bacterias que podem ser encontradas colonizando o sistema genital feminino, de maneira normal ou nao, sao relevantes para o diagnostico copocitologico das vaginoses e vaginites. A analise critica quanto ao potencial infeccioso dos microorganismos em questao bemcomo das alteracoes de esfregaco por eles induzidas sao tambem de fundamental importância.
|
2022-02-11T01:43:29.774Z
|
34,023,122 |
{
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"ArXiv": null,
"DOI": "10.1056/NEJMIMC1516704",
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"url": null
}
|
This interactive feature presents a 43-year-old man who presented to the emergency department with abrupt onset of abdominal pain. Test your diagnostic and therapeutic skills at NEJM.org.
|
2022-02-12T09:41:02.723Z
|
40,963,124 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/1756-185X.12923",
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|
Pulmonary thromboembolism (PTE) is rarely reported in Behçet's disease (BD) due to its distinctive thrombus‐forming mechanism. In BD, the inflammation on vessel walls causes venous thrombosis. The thrombi are considered to be tethered to the inflamed walls making embolization less frequent. Thus, immunosuppressive agents are the mainstay of treatment. However, the necessity of anticoagulation therapy is controversial because of its uncertain efficacy of resolving thrombi and the possibility of fatal side effects of hemorrhage. A 25‐year‐old man with recurrent oral aphthae visited with abrupt onset of dyspnea and chest pain. Based on history, imaging studies and laboratory results, he was diagnosed with BD with vascular involvement and antiphospholipid syndrome (APS), causing PTE from deep vein thrombosis. The co‐existing APS may have further promoted the thrombosis, shifting his blood profile toward the hypercoagulable state. Immunosuppressive therapy with glucocorticoid and azathioprine, and concomitant anticoagulation with warfarin were achieved successfully without any fatal complications. When atypical features of vascular involvement in BD develop, other coexisting diseases should be considered to design an optimal therapeutic plan.
|
2022-02-12T04:05:41.379Z
|
55,873,183 |
{
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"ArXiv": null,
"DOI": "10.7508/CEIJ.2015.02.002",
"MAG": "2176402235",
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|
This paper deals with the dynamic analysis of stress field in cylindrically layeredstructures reinforced by carbon nanotube (CLSRCN) subjected to mechanical shock loading.Application of meshless local integral equations based on meshless local Petrov-Galerkin(MLPG) method is developed for dynamic stress analysis in this article. Analysis is carriedout in frequency domain by applying the Laplace transformation on governing equations andthen the stresses are transferred to time domain, using Talbot inversion Laplace techniques.The mechanical properties of the nanocomposite are mathematically simulated using fourtypes of carbon nanotube distributions in radial volume fraction forms. The propagation ofstresses is indicated through radial direction for various grading patterns at different timeinstants. The effects of various grading patterns on stresses are specifically investigated.Numerical examples, presented in the accompanying section 4 of this paper, show thatvariation of *CN V has no significant effect on the amplitude of radial stresses. Examplesillustrate that stress distributions in cylindrical layer structures made of a CNT type aremore sensitive rather than other grading pattern types of CNTs. Results derived in thisanalysis are compared with FEM and previous published work and a good agreement isobserved between them.
|
2022-02-11T19:40:58.401Z
|
7,215,497 |
{
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"ArXiv": null,
"DOI": "10.1103/PHYSREVE.53.4229",
"MAG": "2000977338",
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"status": null,
"url": null
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|
We examine analytically the linear operation of relativistic traveling wave tube amplifiers. In this regime it is found that the maximum growth rate occurs at a beam velocity below that expected on the basis of resonance with the cold dispersion relation of the slow wave structure. The maximum growth rate can be much larger than that at the resonance condition. These results have significance when extending Pierce{close_quote}s theory to traveling wave amplifiers driven by relativistic electron beams. {copyright} {ital 1996 The American Physical Society.}
|
2022-07-29T11:07:02.207Z
|
157,611,798 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1163/2211906X-00601002",
"MAG": "2614610342",
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},
"license": null,
"status": null,
"url": null
}
|
This article provides comprehensive insights into the study of the Ghana legal system as an academic discipline in the law faculties in Ghana. It urges the view that the study of the Ghana legal system, as an academic discipline, should be transsystemic. Transsystemic pedagogy consists in the introduction of ideas, structures and principles which may be drawn from different legal traditions such as civil law, common law, religion-based law, African law and socialist law traditions to influence the study of law. Transsystemia involves teaching law ‘across,’ ‘through,’ and ‘beyond’ disciplinary fixations associated with a particular legal system. It is a mode of scholarship that defies biased allegiance to one legal tradition in order to foster cross-cultural dialogue among legal traditions. It involves a study of law that re-directs focus from one concerned with ‘pure’ legal system to a discourse that is grounded on multiple legal traditions.
|
2022-07-30T05:45:22.037Z
|
205,491,428 |
{
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"ArXiv": null,
"DOI": "10.1111/j.1442-2050.2010.01160.x",
"MAG": "1782138359",
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"license": null,
"status": "BRONZE",
"url": "https://academic.oup.com/dote/article-pdf/24/6/381/10395618/dote0381.pdf"
}
|
Dysplasia and esophageal adenocarcinoma may arise in patients with Barrett's esophagus after fundoplication esophageal pH monitoring showing no acid in esophagus. This suggests the need to develop methodology to evaluate the occurrence of ultra-distal reflux (1cm above the LES). The objective of the study was to compare acid exposition in three different levels: 5cm above the upper border of the LES, 1cm above the LES and in the intrasphincteric region. Eleven patients with Barrett's esophagus after Nissen fundoplication with no clinical, endoscopic and radiologic evidence of reflux were selected. Four-channel pH monitoring took place: channel A, 5cm above the upper border of the LES; channel B, 1cm above the LES; channel C, intrasphincteric; channel D, intragastric. The results of channels A, B and C were compared. There was significant increase in number of reflux episodes and a higher fraction of time with pH <4.0 in channel B compared to channel A. There was significant decrease in fraction of time with pH <4.0 in channel B compared to channel C. Two cases of esophageal adenocarcinoma were diagnosed in the studied patients. The region 1cm above the upper border of the LES is more exposed to acid than the region 5cm above the upper border of the LES, although this exposure occurred in reduced levels. The region 1cm above the upper border of the LES is less exposed to acid than the intrasphincteric region.
|
2022-12-10T10:06:54.610Z
|
23,432,601 |
{
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"ArXiv": "nlin/0209029",
"DOI": "10.1103/PhysRevE.65.046216",
"MAG": "2041715682",
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|
Dynamical and statistical properties of the vortex and passive particle advection in chaotic flows generated by 4- and 16-point vortices are investigated. General transport properties of these flows are found to be anomalous and exhibit a superdiffusive behavior with typical second moment exponent mu approximately 1.75. The origin of this anomaly is traced to the presence of coherent structures within the flow, the vortex cores, and the region far from where vortices are located. In the vicinity of these regions stickiness is observed and the motion of tracers is quasiballistic. The chaotic nature of the underlying flow dictates the choice for thorough analysis of transport properties. Passive tracer motion is analyzed by measuring the mutual relative evolution of two nearby tracers. Some tracers travel in each other's vicinity for relatively long times. This is related to a hidden order for the tracers, which we call jets. Jets are localized and found in sticky regions. Their structure is analyzed and found to be formed of a nested set of jets within jets. The analysis of the jet trapping time statistics shows a quantitative agreement with the observed transport exponent.
|
2022-12-15T03:10:39.076Z
|
14,634,160 |
{
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"ArXiv": null,
"DOI": "10.1109/CIS.2013.126",
"MAG": "1991526256",
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}
|
Pseudo random numbers are important in various applications. Pseudo random number generators (PRNGs) have been used widely to provide ideal pseudo random number generating sources. Recently the researches on chaos-based PRNGs have also attracted much attention. Based on Li-York's chaotic map criteria, this paper introduces a novel piecewise linear chaotic map (PLCM). Combining the PLCM with the logistic map designs a chaotic PRNG (CPRNG). Using the FIPS 140-2 test suit tests the randomness of two 1000 key streams consisting of 20000 bits and 220 bits, respectively. The results show that for the 1000 key streams consisting of 20000 bits, the statistical properties of the randomness of the sequences generated via the CPRNG and an m-sequence PRNG do not have significant differences. As applications, image encryption examples via the CPRNG and the m-Sequence based PRNG are given.
|
2022-12-21T18:13:45.236Z
|
25,426,956 |
{
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"ACL": null,
"ArXiv": null,
"DOI": "10.1021/es505516w",
"MAG": "2004328221",
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}
|
This study investigated the impacts of buffer ions, natural organic matter (NOM), and particulate Fe(III) on ferrate(VI) decomposition and characterized Fe(VI) decomposition kinetics and exposure in various waters. Homogeneous and heterogeneous Fe(VI) decomposition can be described as a second- and first-order reaction with respect to Fe(VI), respectively. Fe(VI) decay was catalyzed by Fe(VI) decomposition products. Solutes capable of forming complexes with iron hydroxides retarded Fe(VI) decay. Fractionation of the resulting solutions from Fe(VI) self-decay and ferric chloride addition in borate- and phosphate-buffered waters showed that phosphate could sequester Fe(III). The nature of the iron precipitate from Fe(VI) decomposition was different from that of freshly precipitated ferric hydroxide from ferric chloride solutions. The stabilizing effects of different solutes on Fe(VI) are in the following order: phosphate > bicarbonate > borate. The constituents of colored and alkaline waters (NOM and bicarbonate) inhibited the catalytic effects of Fe(VI) decomposition products and stabilized Fe(VI) in natural waters. Because of the stabilizing effects of solutes, moderate doses of Fe(VI) added to natural waters at pH 7.5 resulted in exposures that have been shown to be effective for inactivation of target pathogens. Preformed ferric hydroxide was less effective than freshly dosed ferric chloride in accelerating Fe(VI) decomposition.
|
2022-12-26T16:55:51.225Z
|
238,359,762 |
{
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"ArXiv": null,
"DOI": "10.3389/fnins.2021.724391",
"MAG": null,
"PubMedCentral": "8526737"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.frontiersin.org/articles/10.3389/fnins.2021.724391/pdf"
}
|
Preterm is a worldwide problem that affects infants’ lives significantly. Moreover, the early impairment is more than limited to isolated brain regions but also to global and profound negative outcomes later, such as cognitive disorder. Therefore, seeking the differences of brain connectome between preterm and term infant brains is a vital step for understanding the developmental impairment caused by preterm. Existing studies revealed that studying the relationship between brain function and structure, and further investigating their differentiable connectomes between preterm and term infant brains is a way to comprehend and unveil the differences that occur in the preterm infant brains. Therefore, in this article, we proposed a novel canonical correlation analysis (CCA) with locality preserving projection (LPP) approach to investigate the relationship between brain functional and structural connectomes and how such a relationship differs between preterm and term infant brains. CCA is proposed to study the relationship between functional and structural connections, while LPP is adopted to identify the distinguishing features from the connections which can differentiate the preterm and term brains. After investigating the whole brain connections on a fine-scale connectome approach, we successfully identified 89 functional and 97 structural connections, which mostly contributed to differentiate preterm and term infant brains from the functional MRI (fMRI) and diffusion MRI (dMRI) of the public developing Human Connectome Project (dHCP) dataset. By further exploring those identified connections, the results innovatively revealed that the identified functional connections are short-range and within the functional network. On the contrary, the identified structural connections are usually remote connections across different functional networks. In addition, these connectome-level results show the new insights that longitudinal functional changes could deviate from longitudinal structural changes in the preterm infant brains, which help us better understand the brain-behavior changes in preterm infant brains.
|
2022-12-29T14:32:03.558Z
|
255,220,740 |
{
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"DOI": "10.18137/cardiometry.2022.24.10221027",
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"license": "CCBY",
"status": "GOLD",
"url": "https://s3.timeweb.com/cm94660-20b5ac41-549d-43b0-a32e-a074405a8023/eng/issues/no24-november-2022/mean-platelet-volume.pdf"
}
|
INTRODUCTION: Coronary artery disease is the disease manifested mainly the process of atherosclerosis and their complications. Platelets have a major part in the atherosclerosis process initiation and the formation of thrombus in the coronary vessels. Larger the size of the platelet , higher the risk of thrombosis as it is metabolically and in enzymatic way more active compared to smaller platelets.1 Since MPV gives the measurement of average size of the platelets, MPV measurement predicts the risk of developing Acute coronary syndrome. METHOD: All patients who come to Emergency Department and Out patient Department of Sree Balaji Medical College and Hospital with chest pain who are not a known case of Acute Coronary Syndrome, and fulfilling the inclusion and exclusion criteria will be taken for our study. As soon as patient got admitted , informed consent was obtained from patients and attenders. Initial evaluation involves thorough clinical history and examination, Electrocardiography and Troponin I (biomarker). Venous samples for troponin I and MPV will be taken at the time of arrival and before the treatment initiation and the platelet volume indices are assessed and the correlation between ACS (STEMI, NSTEMI) and Non ACS patients with MPV values are assessed and also among STEMI and NSTEMI patients. RESULTS: Mean platelet volume (MPV) was assessed in our study and we have found it higher in ACS patients (9.716 ± 0.829) compared to the control group (8.730 ± 0.840) , which was significant , P wave of less than 0.05. It was also determined that high MPV values were there among patients who are diagnosed with STEMI as compared with NSTEMI with values of 9.98 ±0.675 and 9.412 ±0.896 , significant statistically (P less than 0.05). CONCLUSION: In our study, MPV values assessed were obtained to be high in ACS diagnosed patients than with Control group and similarly MPV values were high in the patients with STEMI patients more than in NSTEMI and also proved it to be significant . Hence it could be useful as a simple test with other biomarkers in the prediction of ACS earlier. Large platelets are usually metabolically active more , they carry the higher risk of developing coronary thrombosis leading to the Acute coronary syndrome. As this test could be done in routine analysis and could help in ACS early detection.
|
2022-12-30T01:12:36.123Z
|
97,808,211 |
{
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"ArXiv": null,
"DOI": "10.1080/00222338608069476",
"MAG": "2052853068",
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},
"license": null,
"status": null,
"url": null
}
|
Abstract The free-radical copolymerization of ω-unsaturated oligo(methyl methacrylate) (1) with each of ethyl acrylate, styrene, methyl methacrylate, acrylonitrile, and vinyl acetate have been investigated. Incorporation of (1) into the polymer was observed in all cases although the molecular weights of the copolymers were substantially lower than those of the homopolymers obtained in the absence of (1) but under otherwise identical conditions. These experiments, together with a product study of the reactions of (1) with cyanoisopropyl radicals, have shown that the addition of free radicals to the double bond of (1) occurs readily. The sterically hindered radical so formed, however, undergoes facile β-scission, resulting in the termination of chains (chain transfer) in competition with chain propagation. The implications of these findings to the usefulness of (1) in the synthesis of graft copolymers and their relevance to the chemistry of free-radical polymerizations when methyl methacrylate is employed a...
|
2022-12-31T16:03:01.615Z
|
237,446,915 |
{
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"ArXiv": null,
"DOI": "10.1109/ICoICT52021.2021.9527451",
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},
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"url": null
}
|
The use of game has become a norm for generation-z, whose live revolves around technology. The ease of access towards games via handheld devices such as tablets or smartphones cultivates a specific type of motivation among students. These motivational goals will indirectly influence the ways students investigate tasks that may or may not have a snippet of game-like environments. As such, it will be vital to identify the player motivation among these students. This study used a quasi-experimental design with a one-group post-test-only design. Participants from a tertiary institution were tested using an adapted Bartle Player Motivation questionnaire after learning via an e-learning platform. The overall findings showed that all students have a higher tendency of Achiever player motivation followed by Explorer, Killer, and Socializer. This showed that players go for individualistic games that are played for fun, personal gain, or occupying their time, thus the low level of preference towards socialization. Meanwhile, when differentiating among genders, female students' Achiever Player motivation tendencies are higher than male students, while the Killer Player motivation tendencies of male students are higher than female students. This can be attributed to the morale of female students leaning towards proving or achieving something in a game. Meanwhile, male students have gaming intentions to not only win but dominate others. As such, identifying students' motivation in learning and using technology can guide them in the right path of interest, leading to a personalized learning path.
|
2022-01-24T23:24:43.022Z
|
229,387,142 |
{
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"DOI": "10.20961/SHES.V3I3.46161",
"MAG": "3108902996",
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"url": null
}
|
The purpose of this study was to improve student learning outcomes in the Mathematical muple in grade III elementary schools with the Problem Based Learning (PBL) learning model. The research conducted was a Classroom Action Research (CAR) in two cycles, with each cycle consisting of two meetings. The stages of each cycle are planning, implementing, observing and reflecting. Each meeting is carried out a pre test and post test to determine the progress of students. In cycle I students who completed after carrying out the post test were 53%. In cycle II participants students who complete after carrying out the post test are 90%. These results indicate that the Problem Based Learning (PBL) learning model can improve the learning outcomes of students, especially Class III Mathematics at SDN 1 Randurejo.
|
2022-01-27T01:41:22.555Z
|
114,698,229 |
{
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"ArXiv": null,
"DOI": "10.4028/www.scientific.net/KEM.692.110",
"MAG": "2406197697",
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"status": null,
"url": null
}
|
In an underground R.C. Tunnel constructed as conduit for SS Pipes carrying industrial waste liquid, heavy ingress of ground water was witnessed and had to be overcome. Industrial wastes are to be carried through pipes in pipe system with an outer casing of a 200 mm dia SS pipe. Continuous contact of ground water with the casing SS pipe will deteriorate the pipe with the consequence of mixing of waste with the ground water. To avoid this, tunnel was sealed by enclosing the casing pipe with self-compacting concrete (SCC) for preventing ingress of ground water into the tunnel. As sustainability comprise Economy, Environment and social impact, the use of SCC take care the above factors by utilizing fly ash which replaces cement ,thereby, protecting the environment from industrial waste to produce socially accepted concrete and ensuring sustainable construction.
|
2022-01-27T03:38:53.987Z
|
137,326,006 |
{
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"ArXiv": null,
"DOI": "10.13031/2013.37769",
"MAG": "2075049818",
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}
|
Diesel fuel emulsions have been considered for compression ignition engines to enhance the combustion efficiencies and reduce the harmful exhaust emissions. High NOx emission is one of the limiting factors on extended utilization of biodiesel. The presence of water in fuel emulsions can reduce the NOx emissions. The interaction of biodiesel and surfactant concentrations of water-biodiesel-diesel emulsions on diesel engine exhaust emissions are unclear and need investigation. The objective of this study was to determine the effects of biodiesel and surfactant concentrations of a water-biodiesel-diesel nanoemulsion fuel system on engine performance and exhaust emissions of a compression ignition engine. The results showed that biodiesel nanoemulsions reduced the NOx emissions compared to biodiesel blends at the same biodiesel concentrations. Increasing the surfactant concentration at constant water (10%) and biodiesel concentrations produced higher engine powers. However, biodiesel nanoemulsions significantly increased the BSFC compared to the biodiesel-diesel blends and diesel fuels. Biodiesel nanoemulsions reduced the NOx emissions and exhaust temperature but increased the BSFC and CO emissions.
|
2022-09-05T10:30:41.919Z
|
56,197,390 |
{
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"DOI": "10.5539/ELT.V11N4P138",
"MAG": "2794508905",
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"url": null
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Even though there is plenty of published information about the advantages of peer review, little can be found on what the beneficiaries (i.e. the students) feel about this method and what they might expect from it. In this paper, we present an analysis of the perceptions of 44 students at one of the largest universities in Ecuador, who had just undertaken a course in academic writing which used peer revision as the main tool for improving final essay compositions. The results show that participants of the groups who followed a peer revision approach do believe that they benefited from this method. This conclusion was reached after analysing students’ answers to a questionnaire which comprised closed option (multiple choice) questions as well as open-ended responses on the same three aspects pertaining to the impact of peer review: critical thinking, collaborative work and composition quality. This research is based on Vygotsky’s socio-cultural approach; it also supports and broadens previous investigations on this topic giving a more detailed and deep-rooted perspective, as participants who have used this methodology comment on its benefits and/or flaws.
|
2022-10-19T15:56:26.065Z
|
1,514,559 |
{
"externalids": {
"ACL": null,
"ArXiv": "0706.3150",
"DOI": "10.1088/1126-6708/2007/09/102",
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},
"license": null,
"status": "GREEN",
"url": "http://arxiv.org/pdf/0706.3150"
}
|
Inclusive b-quark production in two-photon collisions has been measured at LEP using an integrated luminosity of 698 pb−1 collected by the ALEPH detector with √ s between 130 and 209 GeV. The b quarks were identified using lifetime information. The cross section is found to be σ(e+e− → e+e−bb̄X) = (5.4 ± 0.8 stat ± 0.8 syst) pb, which is consistent with Next-to-Leading Order QCD.
|
2022-12-23T01:56:36.990Z
|
113,018,190 |
{
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"DOI": "10.3775/JIE.57.384",
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"url": null
}
|
Changes in the coal belnding theory, which is a basic condition for the manufacture of blast furnace coke, are comprehensively considered.Both rank and caking property parameters, founded on the basic concept on coal blending, has been used in the determination of coal blending in practice. Five couples of rank and caking property parameters are analyzed and compared. As a result, it was revealed that the relative positions of each coal group and charged coal for chamber oven are approximately constant, on the axis of co-ordinates of rank and caking property parameters. Therefore, the selection of the method for determining the blending standard is the one of the measuring procedure for the para-meters.At the end the author considered the character of each blending parameter. In future we will have to cope with the new conditions of the enlargement in coal sour-ces, development of new coke making processes and clarification of coke property under heat. For this purpose it was suggested that the texture and constitution of coal, caking property under heat and the texture and constitution of coke should be clarified.
|
2022-02-10T02:46:49.753Z
|
24,391,691 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1021/JF991212M",
"MAG": "2063767393",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The objective of this paper was to study the stability of a medicated premix and a medicated farm feed containing sulfadimidine as the active ingredient. The medicated premix is supplied as powdered form and administered orally after mixing with animal feed. The sulfadimidine analytical method described in United States Pharmacopoeia 23 cannot be used to carry out the stability study because of its lack of specificity for different degradation products. Therefore, a high-performance liquid chromatography method was developed to assay sulfadimidine. This method was optimized and validated for the stability study. According to International Committee Harmonization (ICH) guidelines, the samples were stored under long-term testing and accelerated conditions for the stability study of the premix and the medicated farm feed. Sulfadimidine degradation was not detected in either form under any of the conditions studied.
|
2022-02-12T18:42:38.719Z
|
69,280,962 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5506/APHYSPOLBSUPP.11.707",
"MAG": "2901435882",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
TheMulti Purpose Detector (MPD) experiment at Nuclotron based Ion Collider fAcility (NICA) which is under construction at the Laboratory of High Energy Physics at the Joint Institute for Nuclear Research will be studying relativistic heavy-ion collisions. Such experiments give not only experimental data, but also a variety of operational parameters which should be monitored and controlled during regular operation. For this purpose, the Slow Control System is needed. This paper shows the design brief of the Slow Control System which is being prepared for the MPD-TOF detector.
|
2022-02-11T11:49:00.548Z
|
109,796,304 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/J.1538-7305.1962.TB03272.X",
"MAG": "2022296989",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In the field of microwave tubes, the cold test plays an important role. However, no attempt in this direction has been made for the variable capacitance amplifier. It is the purpose of this paper to present the theory of a cold test procedure for parametric amplifiers. The cold test is essentially the measurement of the impedance locus of the input, the output and the pump circuits under the no-pump condition, with the diode bias voltage as the variable parameter. From these impedance loci one can evaluate all the important circuit parameters of the equivalent circuit of the parametric amplifier, including the value of the dynamic quality factor of the diode. Using these data, it is relatively easy to design or adjust the circuit so as to give the best noise performance. Since the theory of the cold test procedure neglects the effects of (1) higher harmonics, (2) any parallel conductance of the diode, and (3) circuit losses, the validity of the theory can be established only by experiment. For this reason, this paper also presents some of the experimental results obtained with a 6-kmc degenerate amplifier. The correlation between theory and experiment has proved to be excellent.
|
2022-09-07T22:22:00.923Z
|
13,119,310 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/elps.200700614",
"MAG": "2000778394",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Charcot‐Marie‐Tooth (CMT) disease is the most common inherited disorder of the human peripheral nerve, with an estimated overall prevalence of 17‐40/10 000 [1]. The typical phenotype presents peroneal muscular atrophy and pes cavus [2]. CMT is usually divided into two large types, about two‐thirds of the patients have CMT type 1 (CMT1), that affects the layer of myelin (demyelination). In type 2 (CMT2) the nerve fibers are affected (axonal). CMT diseases have autosomal dominant, autosomal recessive, and X‐linked inheritance [1]. The most frequent subtype is 1A (CMT1A) with autosomal dominant transmission, secondary in most cases to a tandem duplication of a 1.5 Mb DNA fragment on chromosome 17p11.2‐p12 [4–7]. In this region, the codification of the peripheral myelin protein 22 (PMP22) takes place. The severity of the disease varies among patients, even within the same family, from almost no symptoms to severe foot‐drop and sensory loss. The PMP22 gene has four exons and is regulated by two promoters located toward the extreme 5′. The origin of the duplication that causes the disease is an uneven exchange of the chromatids during the meiosis. This unequal recombination occurs between two regions that limit the PMP22 gene, described as REP places of 24 kb, proximal and distal [3, 4].
|
2022-09-11T21:58:54.939Z
|
56,097,244 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1021/ACS.JPCC.6B05036",
"MAG": "2482167405",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Magnesium zirconium phosphate, MgZr4P6O24 (MZP), is a magnesium ion conducting ceramic material with potential for application as solid electrolyte in high temperature electrochemical sensor in non-ferrous scrap metal refining and virgin metal alloying operations. In this work, MZP was synthesized using a simple but novel and economical sol–gel route at a significantly reduced temperature. An insight into the calcination process and possible phase transformation at higher temperature was obtained using simultaneous thermogravimetric analysis and differential scanning calorimetry (TGA/DSC). Phase identification of the synthesized material was studied after calcining the powder at 900 °C for 3 h using X-ray diffraction (XRD); a single monoclinic phase was observed at that temperature. However, a trace amount of possible minor second phase, zirconium oxide phosphate [Zr2(PO4)2O], was formed after heating at temperatures T ≥ 1000 °C. Impedance spectroscopy measurements on platinized sintered-MZP pellets were ...
|
2022-12-07T22:31:32.222Z
|
237,503,648 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.7150/thno.63396",
"MAG": null,
"PubMedCentral": "8419039"
},
"license": "CCBYNC",
"status": "GOLD",
"url": "https://doi.org/10.7150/thno.63396"
}
|
Tissue regeneration following injury from disease or medical treatment still represents a challenge in regeneration medicine. Prostaglandin E2 (PGE2), which involves diverse physiological processes via E-type prostanoid (EP) receptor family, favors the regeneration of various organ systems following injury for its capabilities such as activation of endogenous stem cells, immune regulation, and angiogenesis. Understanding how PGE2 modulates tissue regeneration and then exploring how to elevate the regenerative efficiency of PGE2 will provide key insights into the tissue repair and regeneration processes by PGE2. In this review, we summarized the application of PGE2 to guide the regeneration of different tissues, including skin, heart, liver, kidney, intestine, bone, skeletal muscle, and hematopoietic stem cell regeneration. Moreover, we introduced PGE2-based therapeutic strategies to accelerate the recovery of impaired tissue or organs, including 15-hydroxyprostaglandin dehydrogenase (15-PGDH) inhibitors boosting endogenous PGE2 levels and biomaterial scaffolds to control PGE2 release.
|
2022-12-29T16:31:52.503Z
|
131,855,650 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.15359/REE.20-3.13",
"MAG": "2512415439",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In this paper, we deal with conceptual and methodological elements to develop the pedagogical inclusive competence of the professors of higher education in Ecuador. We analyze the current conceptions and the main drawbacks related to the inclusion process in the university environment nowadays. We support a theoretical procedural model, and from the practical standpoint, we implemented the methodological procedures structured in a map of processes to reach an inclusive formative process. The main results are given in the development of the pedagogical inclusive competence and the increase of the inclusion culture at the university, and revealed in the improvement of university curriculum from an inclusive approach, the betterment of the physical and technological infrastructure, the permanent upgrading of professors and putting into practice policies of affirmative action.
|
2022-12-30T00:45:08.003Z
|
171,295,821 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2143/RTL.31.2.2017519",
"MAG": "2404380701",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In radical ecology, the consciousness of human responsibility goes together with deep pessimism concerning the dignity of human beings who are viewed as being the planet's parasites. The ecological movement is at its most important in countries with a Protestant culture. Could this be because of a reaction against a school of thought accused of excessive anthropocentrism ? In this article we examine the relationship between Protestantism, modernity and the disillusionment of the world. This relationship is not simply a causal one, since the desacralization of nature is a fundamental theme in Judaism and in ancient Christianity. We have a look at John Calvin and his legacy, in particular the literary success of Robinson Crusoe. Finally we suggest a perspective which respects human freedom based on the idea created by Albert Schweitzer «Ehrfurcht von dem Leben» - «respect of ail life».
|
2022-02-08T16:54:04.850Z
|
108,686,269 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.16878/gsuiletişim.v6i6.5000004874",
"MAG": "1867215466",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In this text it is mentioned that in the last the three decades capital groups that came from different business branches had started to have very important places in media industry. Television contents have been transformed to a commercial goods, because of that commercial aim. Consequently in order to communicate with mass people, television programme contents have been changed that would not agree with traditional broadcasting comprehension. Mass culture that came from USA has been changing people's consuming attitude all around the world by using the mass communication. The other reason of this change is the aim of multi-national companies that are originated in USA to change the consuming attitudes of people and to harmonize these attitudes with American culture. In the past business world had present people what they need. In today's world the consumers are being oriented to need and consume what the producers offer them. In this bunch all mass communication implements are trying to include readers/listeners/viewers into that consuming world by the advertisements.
|
2022-02-28T12:08:43.639Z
|
109,684,250 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1063/1.1469968",
"MAG": "1565023911",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
We have measured the nuclear fusion cross section for 3He(3He,2p)4He near the solar Gamow peak with a compact accelerator facility OCEAN and with an assembly of counter telescopes with a detection efficiency of 10%. The data obtained at Ecm=45.3 to 31.2 keV improved the existing astrophysical S-factors in statistical and systematic errors. A Monte Carlo simulation program exploiting GEANTS, SRIM and GENBOD computer codes has been developed to estimate the detection efficiency for two proton coincidence with a ΔE-E telescopes. The precision of developed program has been investigated by comparing the simulated results with the experimental values for cross section of the D(3He,p)α reaction carried out by replacing the target with D gas. It turned out that the present study involves around 3% systematic errors for an estimation of the detection efficiency. The overall systematic errors for these data from 45.3 to 31.2 keV is 3.8%, that is as good as those of the previous experiments. The latest data obtained...
|
2022-03-06T04:33:56.218Z
|
247,966,151 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.52600/2763-583x.bjcr.2022.2.2.48-57",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBY",
"status": "HYBRID",
"url": "https://bjcasereports.com.br/index.php/bjcr/article/download/cistite_fungica_por_candida_spp_em_felino_com_historico_de_obstr/cistite_fungica_por_candida_spp_em_felino_com_historico_de_obstr"
}
|
Cistites fúngicas são raras em felinos e normalmente estão precedidas de outras doenças do trato urinário, imunossupressão e tratamentos prévios. O objetivo deste estudo foi relatar um caso de cistite fúngica por Candida spp. em um felino, macho, castrado, de 3 anos de idade sem raça definida (SRD). O animal foi atendido no Hospital Veterinário “Professor Ricardo Alexandre Hippler” localizado na cidade de Vila Velha, Espírito Santo, no ano de 2021, apresentando os sinais clínicos de disúria, periúria, polaciúria e incontinência urinária, além do histórico de desobstrução uretral há dois meses. Na sedimentoscopia urinária foram observadas estruturas compatíveis com fungo, confirmado posteriormente pela cultura de urina que identificou o gênero Candida spp. O tratamento recomendado para o paciente foi o antifúngico Fluconazol administrado por via oral, apresentando melhora dos sinais clínicos após 28 dias de exposição ao tratamento. Com 44 dias do início do tratamento o animal apresentou recidiva dos sinais clínicos, uma nova urinálise e urocultura foi realizada no qual a enterobactéria Klebsiella pneumoniae foi identificada, e a amostra foi negativa para Candida spp. O tratamento com fluconazol foi eficaz para eliminar a cistite fúngica causada posteriormente a desobstrução uretral do paciente, entretanto apresentou cistite bacteriana posteriormente.
|
2022-04-08T00:19:45.794Z
|
248,115,749 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.31358/techne.v21i1.305",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBYNCSA",
"status": "GOLD",
"url": "https://ojs.jurnaltechne.org/index.php/techne/article/download/305/201"
}
|
Sepeda motor merupakan alat transportasi penting di bidang kontruksi. Pengawas kontruksi lebih cepat menuju lapangan kerja yang jaraknya jauh dari kantor pusat atau tidak dapat diakses menggunakan kendaraan roda empat. Saat pengawas kontruksi meninjau pekerjaan di lapangan, sepeda motor diparkir di tempat terbuka dan jauh dari pandangan pengawas sehingga diperlukan sistem keamanan guna melindungi sepeda motor dari tindakan pencurian. Sistem ini terdiri dari perangkat keras seperti sensor fingerprint, GPS U-Blox Neo-6M, NodeMCU sebagai pengendali utama, buzzer sebagai alarm, dan dilengkapi dengan tombol bypass sebagai kunci rahasia, sedangkan perangkat lunaknya yaitu Blynk untuk menampilkan peta melalui Android. Berdasarkan pengujian didapatkan response time sistem untuk mengenali sidik jari, yaitu 0,83 detik, delay time relay dengan metode fingerprint dan metode tombol bypass masing-masing sebesar 1,07 detik dan 0,97 detik. Delay time sangat dipengaruhi oleh kecepatan internet dan kecepatan proses dari nodeMCU. Delay time pada buzzer bila terdapat percobaan menyalakan kendaran yang tidak dikenali sistem, yaitu 0,56 detik. Sedangkan rata-rata akurasi antara modul GPS dengan GPS ponsel adalah 3,85 meter.
|
2022-04-28T10:57:48.691Z
|
55,652,913 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3126/JCMSN.V10I1.12769",
"MAG": "619496643",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Forensic medicine deals with the application of medicine for the purpose of law. It is now commonly used to describe all aspects of forensic caseworks; including forensic pathology, that branch of forensic medicine which investigates death, and clinical forensic medicine, which involves interaction between the law, judiciary and the police involving (generally) living persons. The medico legal investigation system in our country still lags far behind the developed countries. The doctors doing the medico legal and post-mortem work at the district level hospitals are often untrained in this sensitive job. It is a job of great responsibility and to leave it to inexperienced doctors is actually doing injustice to the society. Forensic experts handle a very small part of total medico-legal work as most of them work in private medical colleges which are not permitted to handle the work. Mortuaries are housed in outdated facilities. Exposure to the medical students on medico legal cases including autopsy is done only on a sporadic basis taking them to nearby government hospitals and even if they visit the hospitals, inadequate infrastructure prevents better learning. Private medical colleges are conducting postgraduate course in forensic medicine without handling medico legal cases. There should be a post of forensic medicine specialist, at least at the zonal hospitals and the district hospitals handling more medico legal cases. The private medical colleges, especially those enrolling postgraduate students in the field, must seek permission to conduct medico legal works and the government also should not be reluctant in permitting so as it’s not producing adequate experts in itself as per the need of the country. DOI: http://dx.doi.org/10.3126/jcmsn.v10i1.12769 Journal of College of Medical Sciences-Nepal, 2014, Vol.10(1); 49-54
|
2022-07-27T01:19:35.365Z
|
99,300,403 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.7567/APEX.9.064301",
"MAG": "2397392764",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
For SiC metal–oxide–semiconductor field-effect transistors (MOSFETs), it has been shown that unidentified positive mobile ions are generated in SiO2 after conventional hydrogen annealing, which leads to significant reliability degradation known as bias temperature instability (BTI). Discovering the origin of these mobile ions is important for fabricating highly reliable SiC MOSFETs. On the basis of first-principles calculations, we verified that the BTI of SiC MOSFETs is caused by hydrogen ions combining with CO3-like defects in SiO2. These hydrogen ions dissociate from the CO3-like defects and diffuse “as protons” in SiO2. These results indicate that the observed positive mobile ions are protons.
|
2022-07-31T20:30:59.889Z
|
89,811,473 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.30969/acsa.v2i1.16",
"MAG": "2596882236",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Determinou-se a incidencia fungica na silagem de flor de seda (C. procera S. W.) em associacao ao capim andrequice (L. hexandra). O experimento foi desenvolvido no LPF/LANA/CSTR/UFCG, campus de Patos-PB. Os tratamentos experimentais constaram de silagens formadas pela associacao de flor de seda com pre-secagens em 12, 24 e 36 horas ao capim andrequice nas seguintes proporcoes: 33:67; 66:34; 100:0, respectivamente. O delineamento utilizado foi o inteiramente casualizado, num arranjo fatorial 3 X 3 (niveis de flor de seda e tempos de pre-secagem), com 5 repeticoes. As forragens foram ensiladas em silos experimentais de PVC, que permaneceram lacrados por 90 dias. Apos a abertura dos silos foram colhidas amostras das silagens para isolamento, identificacao e quantificacao dos fungos. Os generos incidentes foram: Aspergillus spp., Epicocum spp., Fusarium spp., Penicilium spp., Torula spp., Nigrospora spp., Mucor spp. e levedura. As silagens, com pre-secagem de 24 horas apresentaram menores valores de fungos toxigenicos, e os niveis crescentes de flor de seda indicaram reducao nos niveis de fungos toxigenicos.
|
2022-08-20T07:51:19.439Z
|
248,136,968 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.21037/atm-22-999",
"MAG": null,
"PubMedCentral": "9073784"
},
"license": "CCBYNCND",
"status": "GOLD",
"url": "https://atm.amegroups.com/article/viewFile/92900/pdf"
}
|
Background Little is known about the anatomical changes in lumbosacral vertebrae and their correlation with facet joint-derived low back pain in patients with hip osteoarthritis (HOA) after total hip arthroplasty. Methods Seventy-four HOA patients with low back pain who underwent initial total hip arthroplasty were included. Their Harris Hip Score (HHS), Oswestry Disability Index (ODI), Visual Analogue Scale (VAS) and anatomical parameters were analyzed. Paired t-tests were used to compare the various index scores before and after surgery, and independent sample t-tests were used for the between-group comparisons. Results The HHS and ODI significantly changed at 3 and 6 months postoperatively [HHS: preoperative (43.56±4.34) vs. 3 months (80.34±5.23) vs. 6 months (84.37±4.78); ODI: preoperative (36.26±5.34) vs. 3 months (26.44±3.23) vs. 6 months (19.34±3.27); P<0.001]. At the first 3 months after surgery, the VAS low back pain score decreased from 5.24±1.21 to 2.89±1.03 (P<0.001), and the VAS hip pain score decreased from 7.45±1.32 to 2.34±1.12 (P<0.001). There was also a statistically significant difference between the preoperative and 1-month postoperative anatomical indices: lumbar lordosis (LL) increased significantly after surgery [preoperative (43.46°±13.89°) vs. 1 month (48.27°±14.42°), P=0.001], while slip angle (SA) decreased significantly [preoperative (89.20°±5.03°) vs. 1 month (84.45°±4.89°), P=0.010]. Sacral slope (SS) and radial abduction angle (RAA) showed significant postoperative changes compared with preoperative assessments; after surgery, SS increased significantly [preoperative (31.33°±8.23°) vs. 1 month (37.65°±8.19°), P=0.006), while RAA decreased significantly [preoperative (42.32°±8.12°) vs. 1 month (35.45°±7.67°), P=0.021]. Moreover, the increase of LL was both significantly correlated with the decrease of the VAS low back pain (P=0.009) and the VAS hip pain score (P=0.038). Conclusions Total hip arthroplasty was associated with the anatomical changes in lumbosacral vertebrae.
|
2022-08-29T05:43:51.221Z
|
154,264,363 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2753/PET1061-1991430689",
"MAG": "2015603682",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The funds being allocated for the technical retooling of all sectors of the economy—industry, transport, agriculture, construction and the building industry, and many services spheres—have been decreasing year by year since the first years of restructuring. Some sectors (for example, light industry) have long since dropped to the zero level for this indicator. This means that the lag in technical sophistication that existed in prior years is now being replaced with total stagnation, with the destruction of entire industrial complexes as its consequence. Unfortunately, these problems are discussed in a unilateral fashion in our economic literature, as a rule, oriented toward looking for ways to achieve macroeconomic stability.
|
2022-09-14T07:20:29.879Z
|
153,836,270 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/J.1937-5956.2007.TB00264.X",
"MAG": "2027844153",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Information delays exist when the most recent inventory information available to the Inventory Manager (IM) is dated. Such situations arise when it takes a while to process the demand data, count the inventory, and pass the results to the IM. We show that the optimal total inventory-related cost decreases when the length of the information delay decreases. The amount of the decrease is an important datum for an IM interested in considering whether or not to invest in reducing the delay. The investment is required to finance design and acquisition of an information (collection and dissemination) system that can reduce the information delay. Such systems include phone calls, business meetings, and the use of information collection mechanisms such as radiofrequency identification tags.
|
2022-09-15T01:59:58.458Z
|
94,530,025 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1021/AC00164A021",
"MAG": "1976620811",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Procedural blanks from commercial solid-phase extraction (SPE) cartridges have been characterized. Alkanes, alkenes, plasticizers, and antioxidants were identified as possible interference compounds by extracting components of the cartridges and by analyzing these extracts by GC/MS. Most of the compounds identified in the extracts were also observed in the procedural blanks from use of the SPE cartridges.
|
2022-12-03T12:32:14.237Z
|
16,103,461 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1093/ehjci/jet246",
"MAG": "2147102404",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://academic.oup.com/ehjcimaging/article-pdf/15/2/233/7121067/jet246.pdf"
}
|
We have read with great interest the article ‘Expert consensus for multi-modality imaging evaluation of cardiovascular complications of radiotherapy in adults: a report from the European Association of Cardiovascular Imaging and the American Society of Echocardiography’ by Lancellotti et al .1 Late cardiovascular complications after chest radiotherapy (RT), even modern RT techniques, are a remarkably increasing problem. Care of cancer survivors is becoming an emergent and topic issue especially after chest irradiation and more so for left breast cancer patients.2 In this subset of patients, RT should be addressed a risk factor for coronary artery disease (CAD) and …
|
2022-11-25T00:26:49.075Z
|
248,375,215 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1177/1358863X221091320",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Background: Despite strong association of elevated lipoprotein (a) (Lp(a)) levels with incident coronary and cerebrovascular disease, data for incident peripheral artery disease (PAD) are less robust. The main objective of the present systematic review was to analyze the association between elevated Lp(a) levels and PAD outcomes. Methods: This systematic review was performed according to PRISMA guidelines. A literature search was performed to detect randomized clinical trials or observational studies with a cohort design that evaluated the association between Lp(a) levels and PAD outcomes. Results: Fifteen studies including 493,650 subjects were identified and considered eligible for this systematic review. This systematic review showed that the vast majority of the studies reported a significant association between elevated Lp(a) levels and the risk of PAD outcomes. The elevated Lp(a) levels were associated with a higher risk of incident claudication (RR: 1.20), PAD progression (HR: 1.41), restenosis (HR: 6.10), death and hospitalization related to PAD (HR: 1.37), limb amputation (HR: 22.75), and lower limb revascularization (HR: 1.29 and 2.90). In addition, the presence of elevated Lp(a) values were associated with a higher risk of combined PAD outcomes, with HRs in a range between 1.14 and 2.80, despite adjusting for traditional risk factors. Heterogeneity of results can be explained by different patient populations studied and varying Lp(a) cut-off points of Lp(a) analyzed. Conclusion: This systematic review suggests that evidence is available to support an independent positive association between Lp(a) levels and the risk of future PAD outcomes. PROSPERO Registration No.: 289253.
|
2022-12-14T09:24:30.264Z
|
28,407,688 |
{
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"DOI": "10.1177/1076029610378500",
"MAG": "2103093284",
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},
"license": null,
"status": null,
"url": null
}
|
Local anesthetics have been reported to have anticoagulant properties, but the mechanisms responsible for this action are poorly understood. Here, we evaluated the in vitro effects of 3 local anesthetics—lidocaine, ropivacaine, and bupivacaine—on the tissue factor expression by monocytes. Monocytes from peripheral blood were stimulated with lipopolysaccharide (LPS) in the presence or absence of local anesthetics. All 3 local anesthetics inhibited the expression of tissue factor antigen and tissue factor activity in LPS-stimulated monocytes in a dose- and time-dependent manner and reduced tissue factor messenger RNA (mRNA) expression in endothelial cells and a monocytic cell line. None of the 3 drugs induced apoptosis or affected the viability of monocytes. Our findings that local anesthetics inhibited the tissue factor induction in activated monocytes by inhibiting tissue factor mRNA level may demonstrate the feasibility of using local anesthetics in hypercoagulable and inflammatory conditions.
|
2022-12-17T23:41:46.828Z
|
5,335,144 |
{
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"ACL": null,
"ArXiv": null,
"DOI": "10.1021/bi7014234",
"MAG": "2059079445",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "https://europepmc.org/articles/pmc4662662?pdf=render"
}
|
The umbrella and penknife models hypothesize that insecticidal Bacillus thuringiensis Cry toxins partition into the apical membrane of the insect midgut by insertion of only two alpha-helices from domain I of the protein, alpha-helices 4 and 5 in the case of the umbrella model and alpha-helices 5 and 6 in the case of the penknife model. Neither model envisages membrane partitioning by domains II and III. In this study, we present data suggesting that mutations in the domain II residue, F371, affect insertion of the whole toxin into Manduca sexta brush border membrane vesicles (BBMVs). Using steady state fluorescence measurements combined with a proteinase K protection assay, we show that mutants of F371 have lost their ability to insert into the BBMV, even though binding to cadherin is almost unaffected. The study also identifies a difference in partitioning of toxins into artificial lipid vesicles (SUVs) as opposed to native BBMVs. While the F371 mutations block insertion of domains I and II into BBMVs, they only block domain II insertion into SUVs. Bioassay and voltage clamping of midguts also confirm the fluorescence data that the noninserting mutants are nontoxic. Our study leads us to propose that, in contrast to previous models of individual free helices inserting into the membrane, the toxin enters into the membrane as a whole molecule or oligomers of the molecule, wherein the domain II residue F371 has a vital role to play in membrane insertion.
|
2022-12-25T23:07:06.774Z
|
144,782,625 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.1353/RHE.1998.0003",
"MAG": "2033468424",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This paper summarizes findings from classic and contemporary research on campus racial climate according to a four-dimensional model: (a) an institution's historical legacy of inclusion or exclusion of various racial/ethnic groups, (b) its structural diversity, or the numerical representation of various racial/ethnic groups, (c) the psychological climate of perceptions and attitudes between and among groups, and (d) the behavioral climate, of campus intergroup relations. For each dimension, the paper recommends ways to enhance educational policy.
|
2022-12-28T20:33:15.431Z
|
15,465,635 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1145/2591888.2591916",
"MAG": "2059999325",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This paper describes the framework and initiatives followed by Colombia to foster e-participation. E-participation implies openness and inclusiveness and the current ICT policy provides the basics for the accomplishment of such principles as the progress in infrastructure, access to services, applications and citizens and public servants capacities has enabled citizens' engagement. In addition, e-participation involves the provision of information, consultation and decision-making. The Crystal Ballot Box facilitates those three levels of participation so it becomes a relevant example of active e-participation in Colombia.
|
2022-01-27T19:08:30.310Z
|
244,972,787 |
{
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"ArXiv": null,
"DOI": "10.22054/IJER.2021.60686.976",
"MAG": "3211124579",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
ضرورت ایجاد شرایط پایدار و شفاف اقتصادی باعث شده است که مبارزه با پولشویی به عنوان یک خطمشی جهان شمول توسط همه کشورها در دستور کار مجالس و دولتها قرار گیرد. این موضوع در حال حاضر مساله خاص کشور در نظام پولی و بانکی محسوب میشود. براساس تجارب سایر کشورها، به کارگیری عوامل رویکرد زیرساختی شامل تمام ابعاد موثر در سازوکارهای بینالمللی مبارزه با پولشوئی، نظیر شاخص کمیته بال و توصیههای گروه ویژه اقدام مالی موجب ارتقاء جایگاه پولی و بانکی ایران در سطح بینالملل و محدود سازی پولشویی میگردد. در این پژوهش، به منظور شناسایی چالشهای این حوزه و دستیابی به الگویی که در برگیرنده مجموعهای از عوامل زیرساختی در مبارزه با پولشویی باشد از دو بخش کمی و کیفی استفاده شده است؛ در بخش کیفی، از معیارهای برخواسته از نظر خبرگان به روش مصاحبه حضوری و کدگذاری چند مرحلهای، تحلیل محتوایی و روش دلفی فازی و در بخش کمی از پرسشنامه و تکنیک تحلیل عاملی و در برازش الگو از شاخص RMSEA استفاده شده است. یافتههای پژوهش حاکی از این است که به کارگیری نظاممند الگوی زیرساختی بر مبنای رهنمودهای بینالمللی شامل ابعاد کارکردی، زمینهای و ساختاری موجب بهبود کارایی سیستم مبارزه با پولشویی و مدیریت بهینه چالشهای مبارزه با پولشویی در بانکها میگردد. از میان عوامل سهگانه الگوی پیشنهادی در این پژوهش، بعد ساختاری به لحاظ اولویت در وزن نسبی که مؤلفههای قانونی، سیاسی، ژئوپولیتیک و ریسک پذیری دارند، اهمیت و لزوم تمرکز بر مؤلفههای مربوط به آن را در نظام بانکی روشن میسازد.
|
2022-01-27T12:30:06.250Z
|
83,463,397 |
{
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"DOI": "10.1177/0894318419826256",
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},
"license": null,
"status": "CLOSED",
"url": null
}
|
The following introduction discusses education related to evidence-based practice in nursing curricula.
|
2022-02-11T01:22:45.093Z
|
248,900,116 |
{
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"DOI": "10.12962/j23373539.v10i2.64907",
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},
"license": "CCBYSA",
"status": "GOLD",
"url": "https://ejurnal.its.ac.id/index.php/teknik/article/download/64907/6897"
}
|
Abstrak—Frangible bullet harus memiliki karakteristik sesuai dengan standar. Untuk menganalisa karakteristik proyektil dapat dilakukan secara eksperimen dan simulasi menggunakan metode elemen hingga. Simulasi pada proyektil dapat menganalisa pengaruh tekanan terhadap distribusi tegangan yang terjadi pada proyektil. Untuk memproduksi proyektil digunakan mesin kompaksi hidrolik 4 kolom yang memiliki tingkat akurasi yang tinggi. Pada jurnal ini dilakukan analisa pengaruh variasi tekanan terhadap distribusi tegangan pada proyektil. Berdasarkan hasil simulasi semakin tinggi variasi tekanan yang diberikan, semakin tinggi distribusi tegangan yang terjadi pada proyaktil. Hasil simulasi menunjukkan pada variasi tekanan yang diberikan diperoleh hasil distribusi tegangan maksimal yaitu 240 Mpa. Nilai distribusi tegangan tesebut masih dibawah nilai yield strength material yang sebesar 280 MPa sehingga kekuatan tekan proyektil dapat mencapai lebih dari variasi tekanan yang diberikan.
|
2022-08-20T16:48:22.902Z
|
246,343,645 |
{
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"ACL": null,
"ArXiv": null,
"DOI": "10.3390/math10030374",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.mdpi.com/2227-7390/10/3/374/pdf?version=1643187721"
}
|
Selecting the most miniature possible set of genes from microarray datasets for clinical diagnosis and prediction is one of the most challenging machine learning tasks. A robust gene selection technique is required to identify the most significant subset of genes by removing spurious or non-predictive genes from the original dataset without sacrificing or reducing classification accuracy. Numerous studies have attempted to address this issue by implementing either a filter or a wrapper. Although the filter approaches are computationally efficient, they are completely independent of the induction algorithm. On the other hand, wrapper approaches outperform filter approaches but are computationally more expensive. Therefore, this study proposes an enhanced gene selection method that uses a hybrid technique that combines the Symmetrical Uncertainty (SU) filter and Reference Set Harmony Search Algorithm (RSHSA) wrapper method, known as SU-RSHSA. The framework to develop the proposed SU-RSHSA includes numerous stages: (1) investigate a novel gene selection method based on the HSA and will then determine appropriate values for the HSA’s parameters, (2) enhance the construction process of the initial harmony memory while satisfying the diversity of the solution by embedding a reference set within the HSA (RSHSA), and (3) investigates the effect of integrating Symmetrical Uncertainty (SU) as a filter and RSHSA as a wrapper (SU-RSHSA) to maximize classification accuracy by leveraging their respective advantages. The results demonstrate that the SU-RSHSA outperforms the original HSA and SU-HSA in terms of classification accuracy, a small number of selected relevant genes, and reduced computational time. More importantly, the proposed SU-RSHSA gene selection method effectively generates a small subset of salient genes with high classification accuracy.
|
2022-10-07T00:15:37.827Z
|
253,105,430 |
{
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"ArXiv": null,
"DOI": "10.12746/swrccc.v10i45.1101",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBYSA",
"status": "GOLD",
"url": "https://pulmonarychronicles.com/index.php/pulmonarychronicles/article/download/1101/2331"
}
|
Sedative medications have been used in intensive care units (ICU) to minimize discomfort, prevent pain /anxiety, allow invasive procedures, reduce stress, and improve synchrony in mechanically ventilated (MV) patients. However, these drugs can have adverse effects resulting in increased length of ICU/hospital stay, health care costs, morbidity, and mortality. This review summarizes the mechanisms of action, usual doses, side effects, adverse effects, contraindications, and recent studies of sedatives which are frequently used in adult ICUs and the sedation assessment tools for measuring quality and depth of sedation in adult ICU patients.
Keywords sedations, mechanical ventilation, intensive care unit, sedation assessment tools
|
2022-10-28T01:14:18.939Z
|
85,122,401 |
{
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"ArXiv": null,
"DOI": "10.1017/S003118200000963X",
"MAG": "2051642423",
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},
"license": null,
"status": null,
"url": null
}
|
This peculiar larval form of cestode, parasitic in man, was first discovered in a Japanese woman (Case I) on 9. vii. 1904, and described by Prof. Ijima in 1905. Subsequently it was found in an American by Dr H. Gates, of Manatee, Florida, in June, 1907, and described by Dr Charles Stiles, who had received Gates' specimens for identification on 25. v. 1908. In the same year in which Gates' case was recorded, we observed a second case (Case II) in Japan. In this case an enormous number of worms were present and they were generally larger than those from the former Japanese and American cases. Recently a patient suffering from the same form of cestode larva (Case III) was found in the Dermatological Institute of the Imperial University of Kyoto.
|
2022-11-18T01:16:53.578Z
|
27,326,878 |
{
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"DOI": "10.1021/JA053462R",
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},
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"url": null
}
|
A ruthenium-catalyzed hydrative cyclization of enynes has been developed. The reaction converts a range of 1,5-enynes bearing terminal alkyne and Michael acceptor moieties into cyclopentanone derivatives. From extensive catalyst screening experiments, a trinuclear ruthenium complex, [Ru3(dppm)3Cl5]PF6, has been identified to be an effective catalyst in mediating the 1,1-difunctionalization of alkynes. It is proposed that this novel umpolung reaction proceeds through the formation of a ruthenium vinylidene, anti-Markovnikov hydration, and intramolecular Michael addition of an acyl ruthenium to the alkene.
|
2022-12-11T06:39:25.038Z
|
110,519,769 |
{
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"ArXiv": null,
"DOI": "10.15623/IJRET.2013.0207019",
"MAG": "2161349596",
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},
"license": null,
"status": null,
"url": null
}
|
Mechanic studies realized on the two dimensional be ams structures with swivel joints show that in stat ics, the vertical displacement is continuous, but the rotation is discontinuous at th e node where there is a swivel joint. Moreover, in dynamics, many authors do not usually take into account the friction effect, mode ling of these structures. We propose in this paper, a modeling of the beams structures with swivel joints which integrates viscosity effec ts in dynamics. Hence this work we will present the formulation of motion equations of such structures and the modal analysis method wh ich is used to solve these equations.
|
2022-02-10T05:05:00.572Z
|
141,518,558 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.7202/1022239AR",
"MAG": "338812281",
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},
"license": null,
"status": null,
"url": null
}
|
Ce texte propose une reflexion sur les enjeux et les modalites de prestation de services publics par des organisations cooperatives. Les auteurs s’attachent tout d’abord a decrire le contexte de cette problematique recente, autour de la dynamique de recomposition des rapports entre Etat, marche, economie sociale et cooperative. Pourquoi sous-traiter des services publics ? Quelle place les cooperatives peuvent-elles prendre dans la prestation de services publics ? Ces questions sont envisagees a la lumiere de travaux de recherche presentes dans l’article. Dans un second temps, six experiences representatives des trois niveaux de gouvernement canadien — municipal, provincial et federal — sont analysees. Les auteurs soulignent la diversite des modalites de sous-traitance developpees au travers de ces experiences encore recentes. Certaines tendances sont egalement degagees, relatives aux conditions de reussite et d’echec de telles experimentations de sous-traitance de services publics sous forme cooperative.
|
2022-08-26T14:19:52.151Z
|
86,280,657 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5539/JPS.V2N1P145",
"MAG": "2147057305",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
An investigation was undertaken to find out the effect of paclobutrazol and post flowering foliar nutrient sprays on harvesting, yield and fruit quality of karonda. Seven treatments consisted of foliar application of paclobutrazol (100 ppm) before flowering and combinations of urea (1%), KNO 3 (3%) and MKP (0.5%) were studied in randomized block design. Use of foliar application of paclobutrazol and nutrients accelerated harvesting in karonda. All foliar sprays improved yield and quality of karonda. The treatment T 3 (1% urea at fruit set and 0.5% MKP 20 Days after fruit set) was the best where 64% of total fruits were harvested before rains.
|
2022-09-08T23:04:08.922Z
|
35,792,874 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/ICQR2MSE.2012.6246397",
"MAG": "2095324173",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Wind power emerges as a sustainable energy resource to meet the increasing electricity needs in the next 20-30 years. Power volatility and maintenance costs are the key challenges in harvesting this type of renewable energy. The levelized cost of energy (LCOE) allows the utility and investors to compare the costs of various generation technologies of unequal lifetimes and capacities. In this study we propose a probabilistic-based LCOE model to assess the investment risks by taking into account four major factors: wind speed, system availability, maintenance policy, and spares stock level. Moment methods are applied to estimate the mean and the variance of the energy yield. The goal of the study is to develop a decision aid methodology guiding the wind farmers to minimize the ownership cost by jointly optimizing the maintenance and the spares inventory. We assume the maintenance and repair service is carried by a third party logistics provider. Genetic algorithm is used to search the optimality of the mixed integer non-linear decision model.
|
2022-12-03T05:12:23.167Z
|
103,763,448 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1039/C8TA04621B",
"MAG": "2809141282",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Herein, we explore a strategy for significantly enhancing the photoelectrochemical (PEC) water splitting efficiency by means of a synergistic interaction between plasmonic Au nanoparticles (NPs) and oxygen vacancies in an amorphous black TiO2 (A-B-TiO2) nanoporous film. The interaction between plasmonic metals and semiconductor substrates was investigated, for the first time, showing that A-B-TiO2 would be a better support for plasmonic Au NPs than pristine TiO2 for plasmon-enhanced PEC water splitting. The rationally designed Au@A-B-TiO2 heterostructure significantly increases the plasmonic effect of Au NPs and consequently improves hot electron injection from Au to A-B-TiO2, boosting the separation efficiency of hot electron/hole pairs and leading to considerably improved water splitting performance under solar light irradiation. As a proof-of-concept, the Au@A-B-TiO2 photoelectrode exhibits a photocurrent density of 2.82 mA cm−2 at 1.23 V vs. RHE under AM 1.5G illumination, which is much higher than those of the state-of-the-art Au–TiO2 photoelectrodes for PEC water splitting.
|
2022-12-09T08:22:02.953Z
|
229,178,454 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/jum.15596",
"MAG": "3111285710",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
To the Editor: We read with great attention the article published by Martire et al. We congratulate the authors on investigating an important scientific area: the appearance of the pelvis on ultrasound imaging after surgery for endometriosis. The authors report that this is “the first study to describe the transvaginal ultrasound features of patients who were surgically treated by laparoscopic segmental rectosigmoid resection” for deep endometriosis (DE). We would like to point out that in 2020, our team published a research study entitled “Ultrasound Evaluation of Pouch of Douglas Obliteration and Rectal Deep Endometriosis in Women Who Have Had Previous Combined Colorectal and Gynaecological Laparoscopic Surgery for Rectal Endometriosis: A Pilot Study”. Compared to our study, this study found similarly high rates of pouch of Douglas (POD) obliteration after bowel surgery for DE (Martire et al, 58%; versus Alhayo et al, 36.4%). We reported a recurrence of bowel DE in 39.1% of participants, whereas Martire et al reported “residual or recurrent” posterior DE in 31.0%. We are glad to see that Martire et al acknowledge the possibility of residual disease, which remains a possibility (including in our study) even when preoperative ultrasound is used. In our study, we included participants who underwent rectal shaving, disk excision, or segmental resection. Hypothetically, rectal shaving or disk excision would be more prone to residual disease than segmental resection. All participants in the study by Martire et al underwent segmental resection, so we wonder whether this residual disease was posterior compartment DE other than rectal. We also wonder whether we are, in fact, observing residual/recurrent rectal DE rather than the aftereffects of surgery on the bowel (eg, fibrosis and anastomosis sites). The sample size in our study was small. Similarly, the sample size reported by Martire et al was small. We acknowledged the inability to adequately report the correlation between postoperative ultrasound findings and symptoms, although a very interesting concept. We are not convinced that there is an association between ultrasound findings and ongoing pain symptoms as suggested by Martire et al. No sample size calculation was performed in this study, and the retrospective design ingrained a high degree of bias. Only those who had an ultrasound examination performed within 6 to 12 months of their surgery were included. Patients who underwent segmental resection with substantial improvement in symptoms may not have returned for a postoperative ultrasound examination, and it is entirely possible that these patients had the same rate of residual/recurrent disease. The study that must be performed involves prospectively and routinely evaluating all patients after surgery for rectal endometriosis and POD obliteration to understand the state of the pelvis, regardless of patient well-being. There will always be a degree of uncertainty about whether noted findings are actual residual/recurrent disease or simply effects of surgery unless patients undergo a second-look laparoscopy. That said, because of the unfortunate chronic and complex nature of endometriosis, many patients do undergo subsequent surgeries in their lives. So, it may be possible to develop some understanding of noninvasive ultrasound findings in individuals who previously underwent advanced pelvic surgery, who may be undergoing reoperation.
|
2022-01-27T01:28:42.683Z
|
88,298,248 |
{
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"ArXiv": null,
"DOI": "10.1158/0008-5472.SABCS-2018",
"MAG": "2324571110",
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"license": null,
"status": null,
"url": null
}
|
Abstract #2018 Background: Overexpression of HER2 is associated with an aggressive cancer and poor prognosis for patients. HER2-positive patients are treated with trastuzumab; however resistance is common. Mechanisms that regulate activity of HER2 or downstream kinase AKT are involved in regulation of survival. Calpains are cysteine proteases involved in transmission of signals during growth, motility and transformation in cancer. Mechanisms by which calpain regulates transmission of signals in HER2-positive breast cancer are not known. Here we investigate possibility that calpain regulates survival in HER2-positive breast cancer.
Material and Methods: Activity of calpain in parental or resistant skbr3 cells was measured alone or in presence of inhibitors under conditions of adhesion or stimulation with trastuzumab using a fluorescently labeled substrate. To investigate regulation of HER2, assays were performed by mixing purified proteins or cell lysates with calpain1. Activity of HER2 was analyzed using phosphotyrosine-specific antibodies in Western blots while cleavage using antibody specific to the C-terminus. HER2-positive cancer tissue or lysates of cell lines were analyzed for presence of C-terminal fragments. Cells were transfected with the plasmid expressing catalytically inactive mutant of calpain1, selected for resistance to G418 and used in experiments to analyze the activity of HER2 and AKT. Sensitivity to trastuzumab was determined by measuring survival in presence of trastuzumab in a 96 well plate assay.
Results: In skbr3 cells, activity of calpain increased following adhesion or stimulation with trastuzumab and was inhibited by inhibitors. Calpain induced cleavage of C-terminal domains and reduced activity in full length HER2. C-terminal fragments were detectable in the lysates of HER2-positive breast cancer tissue, cell lines and also overproduced by overexpression of calpain1. Conversely, in cells expressing catalytically inactive calpain1 the activity of HER2 and AKT was increased correlating with increased survival on fibronectin in the presence of trastuzumab. As another model for calpain-induced regulation of HER2 in mechanisms of resistance, we analyzed regulation in trastuzumab-resistant skbr3 cells. Compared to parental in resistant cells adhesion- or trastuzumab-dependent activity of HER2 was increased whereas cleavage was reduced suggesting mechanisms that regulate generation of C-terminal fragments during transmission of signals were altered. Consistenly, adhesion-dependent activity of calpain was reduced whereas trastuzumab failed to stimulate activation.
Conclusion: These data are consistent with possibilities 1) HER2 is a direct target of calpain, 2) calpain induces cleavage of the cytoplasmic region during transmission of signals to regulate activity and integrity of HER2, 3) calpain-dependent mechanisms are involved in coupling HER2 to survival and 4) inhibition of calpain during adhesion-dependent transmission of signal or in the presence of trastuzumab allows increased activity of HER2 contributing to resistance. Citation Information: Cancer Res 2009;69(2 Suppl):Abstract nr 2018.
|
2022-12-10T01:10:52.339Z
|
248,435,424 |
{
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"DOI": "10.1109/ISEC52395.2021.9764103",
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"status": null,
"url": null
}
|
A smart city is an urban area that uses different types of electronic methods and sensors to collect data. Insights gained from that data are used to manage assets, resources and services efficiently; in return, that data is used to improve the operations across the city. A concept known as Smartainability is a method for assessing the sustainability of a smart city and IoT applications. Without a sound way to assess smart cities functionality, establishing them would be more challenging. The Smart City paradigm aims to improve citizens quality of life in a scenario where the percentage of people living in urban areas is getting higher and higher. The Smartainability approach allows researchers to estimate, with qualitative and quantitative indicators, how smart cities are more sustainable (and smart) in environmental, economical, energetic and social fields, thanks to innovative technologies.As for results, multiple dimensions, KPI (key performance indicators), and quantifications were recorded and analyzed from the case study in charts. This Smartainability development is focused on two aspects; The first aspect is the methodology consolidation and the definition of guidelines to replicate the assessment, the second one is the extension of Smartainability analysis from the Expo site to real city cases. Using this collected data to implement on real city cases could be the next step to establishing functional, interconnected smart cities.
|
2022-12-13T06:52:46.871Z
|
19,280,777 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1167/iovs.09-3998",
"MAG": "2148036948",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "https://europepmc.org/articles/pmc2941168?pdf=render"
}
|
PURPOSE
To critically evaluate whether the adenosine A2A receptor (A2AR) plays a role in postnatal refractive development in mice.
METHODS
Custom-built biometric systems specifically designed for mice were used to assess the development of relative myopia by examining refraction and biometrics in A2AR knockout (KO) mice and wild-type (WT) littermates between postnatal days (P)28 and P56. Ocular dimensions were measured by customized optical coherence tomography (OCT), refractive state by eccentric infrared photorefraction (EIR), and corneal radius of curvature by modified keratometry. Scleral collagen diameter and density were examined by electron microscopy on P35. The effect of A2AR activation on collagen mRNA expression and on soluble collagen production was examined in cultured human scleral fibroblasts by real-time RT-PCR and a collagen assay kit.
RESULTS
Compared with WT littermates, the A2AR KO mice displayed relative myopia (average difference, 5.1 D between P28 and P35) and associated increases in VC depth and axial length from P28 to P56. Furthermore, the myopic shift in A2AR KO mice was associated with ultrastructural changes in the sclera: Electron microscopy revealed denser collagen fibrils with reduced diameter in A2AR KO compared with WT. Last, A2AR activation induced expression of mRNAs for collagens I, III, and V and increased production of soluble collagen in cultured human scleral fibroblasts.
CONCLUSIONS
Genetic deletion of the A2AR promotes development of relative myopia with increased axial length and altered scleral collagen fiber structure during postnatal development in mice. Thus, the A2AR may be important in normal refractive development.
|
2022-12-23T02:02:15.230Z
|
44,051,391 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/TENCON.2008.4766575",
"MAG": "1989374474",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This paper presents the architecture and the VHDL design of an integer 2-D DCT used in the H.264/AVC. The 2-D DCT computation is performed by exploiting itpsilas orthogonality and separability property. The symmetry of the forward and inverse transform is used in this implementation. To reduce the computation overhead for the addition, subtraction and multiplication operations, we analyze the suitability of carry-free position independent residue number system (RNS) for the implementation of 2-D DCT. The implementation has been carried out in VHDL for Altera FPGA. We used the negative number representation in RNS, bit width analysis of the transforms and dedicated registers present in the Logic element of the FPGA to optimize the area. The complexity and efficiency analysis show that the proposed architecture could provide higher through-put.
|
2022-07-12T20:08:05.377Z
|
21,962,953 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/1062936X.2011.604100",
"MAG": "2952118601",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Assessments necessary to ensure the safety of both humans and the environment are challenged by the sheer number of chemicals in use today. Chemical legislation, such as REACH, aims to use alternative methods to reduce the reliance on in vivo animal testing. Consequently, databases such as the TETRATOX database, containing data from the Tetrahymena pyriformis population growth impairment assay, have been used extensively to develop computational models which aid in priority setting and initial hazard assessments. To use any toxicological data, an assessment of quality is required. One important aspect of quality is the repeatability of the assay. This study considered TETRATOX assay data for 85 structurally and mechanistically diverse compounds. The repeatability of replicate determinations was assessed and factors relating to repeatability are discussed. Despite the majority of compounds demonstrating excellent repeatability, it was found that the mechanism of action is likely to be a modulating factor, with compounds acting via electrophilic mechanisms being more likely to exhibit reduced repeatability than those acting via narcotic mechanisms. It is evident from this study that the TETRATOX assay is a robust and highly repeatable assay, suitable for use in toxicological modelling studies and priority setting.
|
2022-09-10T10:14:30.132Z
|
71,630,106 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/uog.6796",
"MAG": "1998366740",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
using a transvaginal approach with a full bladder. Third, we found a significant difference in full LUS between the two approaches (McNemar test, p < 0.05) with a difference greater than 1mm in 35% of the cases and greater than 0.5 mm in 50% of the cases. Finally, the quality of the images were superior with the transvaginal approach in all cases. Conclusion: There is a high reproducibility between transvaginal and transabdominal approach for the identification of the thinnest area of LUS when it is evaluated with a full bladder. However we found only a moderate correlation for the measurements of the full LUS between the two approaches. While we agree that both should be performed, our data and the literature strongly suggest that transvaginal approach is mandatory for the most precise measurement and is likely the optimal approach in the evaluation of LUS for women with prior Cesarean contemplating a vaginal birth.
|
2022-09-11T15:33:59.182Z
|
141,599,287 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4324/9780203783054",
"MAG": "621748517",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A.R. O'Brien, D.S. Tulsky, The History of Processing Speed and Relationship to Intelligence. T.A. Martin, S.S. Bush, Assessment Tools and Research Methods for Human Information Processing Speed. H.A. Demaree, T.W. Frazier, C.E. Johnson, Information Processing Speed: Measurement Issues and its Relationships with Other Neuropsychological Constructs. D. Posthuma, E. de Gues, The Genetics of Information Processing Speed in Humans. R.V. Kail, Speed of Processing in Childhood and Adolescence: Nature, Consequences, and Implications for Understanding Atypical Development. D. Dickinson, J.M. Gold, Processing Speed and the Digit Symbol Substitution Test in Schizophrenia. J.H. Kalmar, N.D. Chiaravalloti, Multiple Sclerosis. G.J. Kinsella, Traumatic Brain Injury and Processing Speed. R.K. Mahurin, Frontal-subcortical Determinants of Processing Speed in Parkinson's Disease. T.A. Salthouse, D.J. Madden, Information Processing Speed and Aging. K. Ball, D.E. Vance, Everyday Life Applications and Rehabilitation of Processing Speed Deficits: Aging as a Model for Clinical Populations. J. DeLuca, Information Processing Speed: How Fast, How Slow and How Come?
|
2022-12-16T00:58:22.178Z
|
254,311,422 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.13048/jkm.22043",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": "GOLD",
"url": "https://www.jkom.org/upload/jkm-43-4-8.pdf"
}
|
Objectives: Parkinson’s disease (PD) patients experience various non-motor symptoms, among which constipation is the second most common after anosmia. However, there are no clear guidelines or effective treatment for constipation in PD.Methods: To investigate the efficacy of Majainhwan (MH) on constipation in patients with PD, we conducted a retrospective chart review study of PD or Parkinsonism patients with constipation who received outpatient or inpatient treatment and whose previous laxatives were replaced by MH from August 2016 to July 2019.Results: In this study, a total of 68 patients’ medical records were reviewed. Among the 44 outpatients with MH treatment, “effective” results were observed in 86.4% patients. Similarly, among the 24 inpatients, “effective” results were noted in 95.8% patients. The adverse effect was "diarrhea" reported in five cases.Conclusion: Based on these findings, we could suggest that MH is relatively safe and may be effective in the treatment of constipation in patients with PD.
|
2022-12-16T03:44:21.858Z
|
34,374,068 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1001/JAMA.285.9.1183",
"MAG": "2087636597",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
CONTEXT
Considerable concern has been generated in the lay and medical communities by a theory that increased measles-mumps-rubella (MMR) immunization among young children may be the cause of an apparent marked increase in autism occurrence.
OBJECTIVE
To determine if a correlation exists in secular trends of MMR immunization coverage among young children and autism occurrence.
DESIGN, SETTING, AND PARTICIPANTS
Retrospective analyses of MMR immunization coverage rates among children born in 1980-1994 who were enrolled in California kindergartens (survey samples of 600-1900 children each year) and whose school immunization records were reviewed to retrospectively determine the age at which they first received MMR immunization; and of autism caseloads among children born in these years who were diagnosed with autism and were enrolled in the California Department of Developmental Services regional service center system.
MAIN OUTCOME MEASURES
Measles-mumps-rubella immunization coverage rates as of ages 17 months and 24 months and numbers of Department of Developmental Services system enrollees diagnosed with autism, grouped by year of birth.
RESULTS
Essentially no correlation was observed between the secular trend of early childhood MMR immunization rates in California and the secular trend in numbers of children with autism enrolled in California's regional service center system. For the 1980-1994 birth cohorts, a marked, sustained increase in autism case numbers was noted, from 44 cases per 100 000 live births in the 1980 cohort to 208 cases per 100 000 live births in the 1994 cohort (a 373% relative increase), but changes in early childhood MMR immunization coverage over the same time period were much smaller and of shorter duration. Immunization coverage by the age of 24 months increased from 72% to 82%, a relative increase of only 14%, over the same time period.
CONCLUSIONS
These data do not suggest an association between MMR immunization among young children and an increase in autism occurrence.
|
2022-12-22T14:19:32.271Z
|
233,669,505 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3390/SU13063441",
"MAG": "3136449470",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
According to the systemic model of community attachment, high residential stability serves as a precondition on which residents build formal and informal social ties within their communities, ultimately resulting in increased community attachment. However, previous studies have only measured residents’ length of residence in the community to measure residential stability, not considering whether expectations of staying in the community in the future affect residents’ community attachment. This study aims to test if mobility expectation influences residents’ community attachment by employing the logistic multilevel model to analyze 31,159 householders from 31 municipalities in Gyeonggi Province, Korea. The results show that residents’ mobility expectation, in addition to the length of residence, is a significant determinant of community attachment after controlling for individual and regional-level covariates. The results provide implications for urban and regional policies aiming to promote community attachment and participation among residents in the age of increasing residential mobility.
|
2022-12-02T10:25:05.503Z
|
202,577,934 |
{
"externalids": {
"ACL": "D19-1097",
"ArXiv": "1909.06937",
"DOI": "10.18653/v1/D19-1097",
"MAG": "2972380590",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Spoken Language Understanding (SLU) mainly involves two tasks, intent detection and slot filling, which are generally modeled jointly in existing works. However, most existing models fail to fully utilize cooccurrence relations between slots and intents, which restricts their potential performance. To address this issue, in this paper we propose a novel Collaborative Memory Network (CM-Net) based on the well-designed block, named CM-block. The CM-block firstly captures slot-specific and intent-specific features from memories in a collaborative manner, and then uses these enriched features to enhance local context representations, based on which the sequential information flow leads to more specific (slot and intent) global utterance representations. Through stacking multiple CM-blocks, our CM-Net is able to alternately perform information exchange among specific memories, local contexts and the global utterance, and thus incrementally enriches each other. We evaluate the CM-Net on two standard benchmarks (ATIS and SNIPS) and a self-collected corpus (CAIS). Experimental results show that the CM-Net achieves the state-of-the-art results on the ATIS and SNIPS in most of criteria, and significantly outperforms the baseline models on the CAIS. Additionally, we make the CAIS dataset publicly available for the research community.
|
2022-12-29T19:13:16.498Z
|
95,823,896 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1063/1.3466550",
"MAG": "2037566623",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The pressure dependent lattice specific heat and mode Gruneisen parameters for III–V nitrides have been calculated using a lattice dynamical model namely the rigid ion model which consists of a usual long range and short range potential. The Murnaghan’s equation of state is adopted for relating the volume dependence with pressure. The non linear least square fitting procedures to obtain the model parameters have been used. The results obtained using the present model calculation on mode Gruneisen parameters and specific are compared with existing experimental data and found in good agreement. There is a increase in in specific heat with pressure. The mode Gruneisen parameters show that the TA phonon mode is responsible for phase transition.
|
2022-02-10T15:04:06.675Z
|
59,516,823 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.19080/JDVS.2018.08.555738",
"MAG": "2908325534",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Enzootic bovine leucosis is an infectious viral disease of cattle distributed worldwide that affect dairy cattle over 2 years of age. This disease produces changes in the animal ́s immune system that may affect vaccine efficacy. During the last 10 years many reports have highlighted the association of BLV infection with a diminished or modified immune response against routinely used cattle vaccines. Our group has focused on studying the possible role of BLV infection on the immune response elicited by foot-and-mouth disease primo or multiple vaccinations making use of serological assays aimed to characterize the antibody response in terms of IgG-subtypes and avidity. These tools demonstrated to be very useful for analyzing the effects of BLV in FMD vaccine immunity. The use of simple high-throughput assays delving on the quality of the antibody response is paramount for assessing vaccine efficacy and can help in analyzing the impact of BLV infection at herd level.
|
2022-07-31T04:42:05.175Z
|
250,856,555 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1088/0264-9381/15/11/011",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "http://arxiv.org/pdf/hep-th/9707239"
}
|
We compute the running of the cosmological constant and Newton's constant at sub-Planckian energies, taking into account the effect of quantum fields with any spin between 0 and 2. We find that Newton's constant does not vary appreciably but the cosmological constant can change by many orders of magnitude when one goes from cosmological scales to typical elementary particle scales. In the extreme infrared, zero modes drive a positive cosmological constant to zero.
|
2022-09-02T02:51:12.228Z
|
118,465,831 |
{
"externalids": {
"ACL": null,
"ArXiv": "1010.0073",
"DOI": "10.1063/1.3533195",
"MAG": "1998102014",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "http://arxiv.org/pdf/1010.0073"
}
|
Answers to some salient questions, which arise in quantum plasmas, are given. Starting from the Schrodinger equation for a single particle it is demonstrated how the Wigner‐Moyal equation can be derived. It is shown that the Wigner‐Moyal type of equation also exists in the classical field theory. As an example, from the Maxwell equations the Wigner‐Moyal type of equation is obtained for a dense photon gas, which is classical, concluding that the Wigner‐Moyal type of equation can be derived for any system, classical or quantum. A new type of quantum kinetic equations are presented. These novel kinetic equations allows to obtain a set of quantum hydrodynamic equations, which is impossible to derive by the Wigner‐Moyal equation. The propagation of small perturbations and instabilities of these perturbations are then discussed, presenting new modes of quantum plasma waves. In the case of low frequency oscillations with ions, a new Bogolyubov type of spectrum is found. Furthermore, the Korteweg‐de Vries (KdV) ...
|
2022-09-07T07:09:53.923Z
|
19,248,702 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/080370598437583",
"MAG": "2169305363",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://www.tandfonline.com/doi/pdf/10.1080/080370598437583?needAccess=true"
}
|
Tsukuba hypertensive mice (THM) are transgenic mice carrying both human renin and angiotensinogen genes, and possessing an overexpressing human renin-angiotensin system. The aim of this study is to evaluate the angiotensin II concentration in the heart and kidney in THM. Twenty-week-old male THM and control C57BL/6 mice (C57) were used. Each group consisted of 3 mice. For each mouse, systolic blood pressure, heart to body weight ratio, renal glomerular sclerosis index and angiotensin II concentration in the heart and kidney were measured. Systolic blood pressure of THM was about 40 mmHg higher than that of C57. Heart to body weight ratio and renal glomerular sclerosis index were significantly higher in THM than those in C57. The angiotensin II concentration in THM was about 4 times higher in the heart and about 5 times higher in the kidney compared with that in C57. These results suggest that accelerated tissue angiotensin II production, significant cardiac hypertrophy and renal glomerular sclerosis all occur because of hypertension.
|
2022-12-02T14:29:18.638Z
|
79,697,543 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.18004/MEM.IICS/1812-9528/2017.015(03)35-040",
"MAG": "2790735972",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Los adultos mayores corresponden una poblacion vulnerable a presentar complicaciones durante su hospitalizacion, pudiendo aparecer una de estas complicaciones durante el soporte enteral, por ello el objetivo de este trabajo fue identificar las complicaciones gastrointestinales, infecciosas y mecanicas durante el soporte enteral en adultos mayores institucionalizados. El diseno fue transversal, en el cual se analizaron fichas de adultos de 60 o mas anos de edad, de ambos sexos, con indicacion de soporte nutricional enteral, internados en el Hospital Geriatrico Dr. Gerardo Buongermini del IPS. Se realizo la revision retrospectiva de 48 historias clinicas, analizandose los datos demograficos, clinicos, de soporte y las complicaciones mediante estadistica descriptiva La mediana de la edad fue 82,5 anos y el 54,2% era del sexo femenino. El 72,9% de los pacientes estaba internado en clinica medica, el 52,1% presento algun tipo de complicacion durante al soporte enteral, siendo estas en orden decreciente: gastrointestinales (60%), infecciosas (44%) y mecanicas (20%). Se encontro que la diarrea (10/11) fue la principal complicacion gastrointestinal. Dentro de las infecciosas, la broncoaspiracion (8/11), y la unica complicacion mecanica fue el autoretiro de la sonda. Todos los pacientes (4/4) con formula artesanal o mixta presentaron complicaciones y estas fueron mas frecuentes en pacientes con forma de administracion tipo bolo y por metodo de infusion continua. En conclusion alrededor de la mitad de los adultos mayores presentaron algun tipo de complicacion durante el soporte enteral.
|
2022-02-11T03:48:08.416Z
|
49,342,433 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/09593330.2018.1491636",
"MAG": "2808729440",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
ABSTRACT Optimizing supports for microorganisms is required for bioreactors. Carbon fibres (CF) were employed as supports for microorganisms. To optimize CF supports for immobilizing bacterial cells, we used methods of nitric acid oxidation and calcium ion coverage. We evaluated the capacity of these CF supports (untreated CF, nitric acid oxidation CF and Ca2+-covered CF) via bacterial cell adhesion tests, based on extended Derjaguin–Landau–Verwey–Overbeek (XDLVO) theory. The results implied that because of the high hamaker constants, oxidized CF supports had higher capacity in this regard than untreated CF supports. However, the growing oxygen groups increased the negative zeta potential of CF supports, thus likely to reduce their capacity, in accordance with XDLVO theory. Since the Ca2+ coverage could decrease the negative zeta potentials of CF without reducing the hamaker constants, it could enhance the capacity of oxidized CF supports. We concluded that a combination of nitric acid oxidation and Ca2+ coverage could increase the capacity of CF supports to immobilize bacterial cells. GRAPHICAL ABSTRACT
|
2022-03-03T17:47:49.374Z
|
215,773,865 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1128/mBio.00112-20",
"MAG": "3015924376",
"PubMedCentral": "7157817"
},
"license": null,
"status": null,
"url": null
}
|
Here, we provide evidence indicating that S. aureus secretes small linear peptides into the environment via a novel processing and secretion pathway. The discovery of a specialized pathway for the production of small linear peptides and the identification of these peptides leads to several important questions regarding their role in S. aureus biology, most interestingly, their potential to act as signaling molecules. The observations in this study provide a foundation for further in-depth studies into the biological activity of small linear peptides in S. aureus. ABSTRACT Staphylococcus aureus can colonize the human host and cause a variety of superficial and invasive infections. The success of S. aureus as a pathogen derives from its ability to modulate its virulence through the release, sensing of and response to cyclic signaling peptides. Here we provide, for the first time, evidence that S. aureus processes and secretes small linear peptides through a specialized pathway that converts a lipoprotein leader into an extracellular peptide signal. We have identified and confirmed the machinery for each step and demonstrate that the putative membrane metalloprotease Eep and the EcsAB transporter are required to complete the processing and secretion of the peptides. In addition, we have identified several linear peptides, including the interspecies signaling molecule staph-cAM373, that are dependent on this processing and secretion pathway. These findings are particularly important because multiple Gram-positive bacteria rely on small linear peptides to control bacterial gene expression and virulence. IMPORTANCE Here, we provide evidence indicating that S. aureus secretes small linear peptides into the environment via a novel processing and secretion pathway. The discovery of a specialized pathway for the production of small linear peptides and the identification of these peptides leads to several important questions regarding their role in S. aureus biology, most interestingly, their potential to act as signaling molecules. The observations in this study provide a foundation for further in-depth studies into the biological activity of small linear peptides in S. aureus.
|
2022-08-23T23:15:06.200Z
|
9,776,945 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/IGARSS.2008.4780119",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Assessment of the radar backscatter from spatially extended geophysical target (SEGT) is under consideration. The SEGT is any geophysical object which is, at least, semi transparent for radar illumination (cloud, rain, snowfall of the atmosphere, thick snow cover of a terrain). It consists of a multitude of point Rayleigh scatterers. The "slice" approach is applied, it means that particles located close to the wave front of the radar illumination produce the backscatter mainly coherently. This approach allows describing the contribution of the microphysical parameters of the scattering media to volume component of the radar cross section (RCS) more comprehensively then the incoherent approach. Known result of the incoherent approach based on summation of RCS from each scatterer takes place in particular case when the fluctuation of particle number within slices is pertaining to the Poisson law.
|
2022-09-02T03:09:01.861Z
|
46,686,594 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1210/ENDO-42-2-129",
"MAG": "2030420482",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Since the discovery by Hisaw (1926) that the separation of the pubic bones in the guinea pig was under the control of a specific substance which was later called relaxin, several controversies have arisen. These controversies are concerned with the identity of this relaxative substance as distinct from the crystalline steroid hormones and with the role played by the steroids in the phenomenon of pubic relaxation. Relaxin was first obtained from the blood of pregnant rabbits (Hisaw, 1926; Brouha and Simmonet, 1928; Tapfer and Haslhofer, 1935; Abramson, Hurwitt and Lesnick, 1937; Marder and Money, 1944). It has also been found in the blood of pregnant sows, dogs, cats, mares and in placentae of rabbits (Hisaw 1927 and 1929), blood of pregnant guinea pigs Hisaw (1927), Zarrow (1947), blood of pregnant women (Pommerenke, 1934; Abramson et al., 1937), and corpora lutea of the sow (Hisaw, 1927; Brouha and Simmonet, 1928; Abramson et al., 1937).
|
2022-09-07T06:22:06.911Z
|
245,780,925 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.54039/ijcnis.v13i3.5096",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://www.ijcnis.org/index.php/ijcnis/article/download/5096/563"
}
|
Power consumption and hardware cost reduction with the use of hybrid beamforming in large-scale millimeter wave MIMO systems. The large dimensional analog precoding integrates with the hybrid beamforming based on the phase shifters including digital precoding with lower dimensionality. The reduction of Euclidean distance between the hybrid precoder and fully digital is the major problem to overcome the minimization of resultant spectral efficiency. The issue formulates as a fully digital precoder’s matrix factorization problem based on the analog RF precoder matrix and the digital baseband precoder matrix. An additional element-wise unit modulus constraint is imposed by the phase shifters on the analog RF precoder matrix. The traditional methods have a problem of performance loss in spectral efficiency. In the processing time and iteration, high complexities result in optimization algorithms. In this paper, a novel low complexity algorithm proposes which maximizes the spectral efficiency and reduces the computational processing time.
|
2022-10-07T00:33:40.169Z
|
86,353,705 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5282/UBM/EPUB.12737",
"MAG": "2147805060",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Scytophyllum is a Triassic seed fern genus to which currently more than 28 species distributed in Eurasia are attributed. Scytophyllum persicum is a characteristic taxon of the Late Triassic flora of Iran and adjacent countries. Discovery of part of the original collection of the conspecific Bernoullia waehneri from the same area and age made a revision of this species necessary that resulted in the proposal of the new combination Scytophyllum waehneri (Stur) nov. comb. since B. waehneri has priority over S. persicum. Scytophyllum waehneri differs from all other species in Scytophyllum in the smaller dimensions of the fronds and pinnae and the distinct secondary veins forming a sort of fishbone structure on the lamina.
|
2022-10-08T14:18:34.306Z
|
125,300,917 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1515/fca-2015-0041",
"MAG": "2564828546",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Abstract In this paper we study fractional differential inclusions in the sense of Almgren. We begin with a discussion of multiple-valued functions in the Almgren sense and include the basic results needed to make the paper selfcontained. Sufficient background on the fractional calculus is provided to make the material accessible also to the non-specialist readers. Our main result gives sufficient conditions for the existence of at least one solution to the problem under investigation. In addition, we show that the solution set to the problem is compact.
|
2022-12-13T14:19:53.706Z
|
14,072,888 |
{
"externalids": {
"ACL": null,
"ArXiv": "hep-th/9707102",
"DOI": "10.1103/PhysRevD.56.6710",
"MAG": "2010506592",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
We consider configurations of D6-branes with a D0-brane charge given by recent work of Taylor and compute interaction potentials with various D-brane probes using a 1-loop open string calculation. These results are compared to a supergravity calculation using the solution given by Sheinblatt of an extremal black hole carrying 0-brane and 6-brane charges. {copyright} {ital 1997} {ital The American Physical Society}
|
2022-12-14T02:34:37.507Z
|
64,030,697 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.7551/mitpress/8811.003.0009",
"MAG": "2384243694",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Petri net is a perfect model to describe and analyze concurrent systems. However, in large or complex applications of the real world, it may run into the problem that the amount of nodes is too large. Colored Petri nets and several hierarchical Petri nets, such as place/transition refinement nets, object nets and open nets are introduced. Also, the methods of deduction of amount of nodes and introduction of hierarchy into models are analyzed and compared. Further, the relations of these models with each other in view of their structures are discussed.
|
2022-12-17T21:54:19.922Z
|
10,698,069 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1136/tobaccocontrol-2014-051840",
"MAG": "2167023092",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "https://europepmc.org/articles/pmc4405407?pdf=render"
}
|
Objective The goal of this study was to summarise the websites of electronic cigarette (e-cigarette) manufacturers in China and describe how they market their products. Methods From March to April 2013, we used two search keywords ‘electronic cigarette’ (Dian Zi Xiang Yan in Chinese) and ‘manufacturer’ (Sheng Chan Chang Jia in Chinese) to search e-cigarette manufacturers in China on Alibaba, an internet-based e-commerce business that covers business-to-business online marketplaces, retail and payment platforms, shopping search engine and data-centric cloud computing services. A total of 18 websites of 12 e-cigarette manufacturers in China were analysed by using a coding guide which includes 14 marketing claims. Results Health-related benefits were claimed most frequently (89%), followed by the claims of no secondhand smoke (SHS) exposure (78%), and utility for smoking cessation (67%). A wide variety of flavours, celebrity endorsements and e-cigarettes specifically for women were presented. None of the websites had any age restriction on access, references to government regulation or lawsuits. Instruction on how to use e-cigarettes was on 17% of the websites. Conclusions Better regulation of e-cigarette marketing messages on manufacturers’ websites is needed in China. The frequent claims of health benefits, smoking cessation, strategies appealing to youth and women are concerning, especially targeting women. Regulators should prohibit marketing claims of health benefits, no SHS exposure and value for smoking cessation in China until health-related, quality and safety issues have been adequately addressed. To avoid e-cigarette use for initiation to nicotine addiction, messages targeting youth and women should be prohibited.
|
2022-12-19T12:44:44.979Z
|
233,929,405 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.36719/2663-4619/62/136-140",
"MAG": "3130338425",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Summary In the modern period of reforms in the education system of our country, large-scale changes are reflected in the teaching of geography, including the teaching of geography in Azerbaijan. Thus, in the country's secondary schools, Azerbaijani geography is taught in all classes on the basis of the principle of succession in geography. Geography of Azerbaijan plays an important role in the teaching of geography in secondary schools. Out of 57 subjects taught in the 10th grade, 16 subjects are taught entirely in Azerbaijani geography. In the 11th grade, 7 out of 44 topics are discussed in their entirety, the geography of Azerbaijan. In addition, the information on the geography of Azerbaijan is reflected in the structure of the problem situation, asking research questions, systematization of information, creative application of the lesson, assessment stages. Key words: education, training, geography of Azerbaijan, map, analysis, assessment, teaching unit, subject, text, illustration, assignment
|
2022-12-20T19:20:33.599Z
|
28,787,278 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/SIBIRCON.2010.5555105",
"MAG": "1979086687",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Wireless Sensor Network is an adhoc network having nodes with constraints like less memory and processing capability. Nodes work without knowledge of their position in the network. After random deployment of nodes, some of the nodes are in critical position as they connect one group of sensor nodes to another. If these nodes are removed from the network it may lead to partitioning of network. Most of the routing protocols identify a node as a bottleneck node depending upon residual energy of the node. The nodes consume considerable amount of energy before they identify themselves as bottleneck nodes. We propose an alternative method to detect the bottleneck nodes in the network just after their deployment, so energy may saved in these bottleneck nodes to increase lifetime of a wireless sensor network. This method also quantify criti-cality of the nodes in the network.
|
2022-12-21T08:46:22.972Z
|
27,225,245 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3390/ijms18122546",
"MAG": "2770968963",
"PubMedCentral": "5751149"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.mdpi.com/1422-0067/18/12/2546/pdf?version=1511885895"
}
|
The physiological function of Arabidopsis thaliana universal stress protein (AtUSP) in plant has remained unclear. Thus, we report here the functional role of the Arabidopsis universal stress protein, AtUSP (At3g53990). To determine how AtUSP affects physiological responses towards cold stress, AtUSP overexpression (AtUSP OE) and T-DNA insertion knock-out (atusp, SALK_146059) mutant lines were used. The results indicated that AtUSP OE enhanced plant tolerance to cold stress, whereas atusp did not. AtUSP is localized in the nucleus and cytoplasm, and cold stress significantly affects RNA metabolism such as by misfolding and secondary structure changes of RNA. Therefore, we investigated the relationship of AtUSP with RNA metabolism. We found that AtUSP can bind nucleic acids, including single- and double-stranded DNA and luciferase mRNA. AtUSP also displayed strong nucleic acid-melting activity. We expressed AtUSP in RL211 Escherichia coli, which contains a hairpin-loop RNA structure upstream of chloramphenicol acetyltransferase (CAT), and observed that AtUSP exhibited anti-termination activity that enabled CAT gene expression. AtUSP expression in the cold-sensitive Escherichia coli (E. coli) mutant BX04 complemented the cold sensitivity of the mutant cells. As these properties are typical characteristics of RNA chaperones, we conclude that AtUSP functions as a RNA chaperone under cold-shock conditions. Thus, the enhanced tolerance of AtUSP OE lines to cold stress is mediated by the RNA chaperone function of AtUSP.
|
2022-12-25T11:09:51.967Z
|
225,522,179 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4108/eai.12-10-2019.2296526",
"MAG": "3046459586",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "http://eudl.eu/pdf/10.4108/eai.12-10-2019.2296526"
}
|
Today in Indonesia there are still many orphanages which have many financial, facilities, and affection limitations considering the orphanage is a place where children are abandoned by their parents. This research proposes implementation the "ePanti" web-based orphanage information system as a means of raising donations. Through this system, benefactors will be able to see profiles of orphanages, lists of orphans, orphanage activities, and how to make donations. This system was developed by the waterfall method which was designed using the Unified Modeling Language (UML) architecture diagram and implemented into the PHP web programming languages using MySQL database system. The system is tested using Black box testing to ensure system functionality and user acceptance tests using questionnaires. The results of this study are the development of the "e-Panti" web-based orphanage information system with a user acceptance rate of 77.50% based on the the questionnaire results.
|
2022-02-08T00:11:05.883Z
|
169,871,614 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2991/ERMS-18.2018.103",
"MAG": "2823542409",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
“ In China, inadequate consumer demand is an outcome of traditional economic growth mode, which used to depending on exports and investment. Since 2008, western states adopted trade protectionism. which hinder China’s export, exacerbate inadequate consumer demand, even hamper economic growth in China. Based on the change of international situation and domestic economic problems, Chinese government put forward new normal economic development policy. It focus on structural adjustment in supply side reform. Seen from the economic history of western states, it proved that industrial structure upgrade once became a major driven force to expand consumer demand, which also became a pushing factor to their economic growth. While in the process of industrial structure adjustment, measures of technology innovation such as internet plus, industrie 4.0 are becoming major force to ease the tension between supply and demand which seemed to be a crux in free market mechanism. In the end, some useful proposals for cultivating new technique and pushing them into social production and consumption.” 基于技术创新的我国消费需求扩大的路径选择
|
2022-02-08T17:38:24.397Z
|
121,959,662 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1093/bjps/axn022",
"MAG": "2051381799",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Sherrilyn Roush's Tracking Truth provides a sustained and ambitious development of the basic idea that knowledge is true belief that tracks the truth. In this essay, I provide a quick synopsis of Roush's book and offer a substantive discussion of her analysis of scientific evidence. Roush argues that, for e to serve as evidence for h, it should be easier to determine the truth value of e than it is to determine the truth value of h, an ideal she refers to as ‘leverage’. She defends a detailed method by which the value of p(h/e) is computed without ‘direct’ information about p(h) but only using evidence about the value of p(e), from which the value of p(h) is derived. She presents an example of how to use her leverage method, which I argue involves a certain critical mistake. I show how the leveraging method can be used in a way that is sound—I conclude with a few remarks about the importance of distinguishing clearly between prior and posterior probabilities.
|
2022-08-27T03:00:31.171Z
|
196,873,211 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/CHIN.201350013",
"MAG": "2949407044",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The three-dimensional flower-like hierarchical title materials are synthesized from Bi(NO3)3 and L-lysine dissolved in aqueous HX (X: Cl, Br, I) at pH 9 adjusted with aq.
|
2022-09-04T01:54:58.977Z
|
26,395,597 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/ajmg.a.34233",
"MAG": "2030062441",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Langer–Giedion syndrome (LGS) (OMIM 150230) is defined as a contiguous gene syndrome caused by loss of functional copies of the TRPS1 and EXT1 genes usually secondary to 8q microdeletion. Tibial hemimelia (TH) is the least common lower limb deficiency characterized by hypoplasia of the tibia with relatively intact fibula. We describe the third report of LGS with bilateral TH and an 8q23.1‐q24.12 interstitial deletion. It is not possible to exclude that this association is fortuitous, but our report reinforces the suggestion of a putative gene involved in limb development in this chromosomal region interval. © 2011 Wiley Periodicals, Inc.
|
2022-12-02T09:11:50.108Z
|
19,708,472 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1097/JSM.0000000000000368",
"MAG": "2467954453",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Objective: To investigate the effects of fatigue induced by a repeated sprint ability (RSA) test on the neuromuscular responses of soccer players with a recent history of lower limb injuries (CH) and a matched control group in good fitness condition (GH). Design: This was a case–control study. Participants: Nine CH and 9 GH. Independent Variable: Allocation to CH or GH. Main Outcome Measures: Each player was assessed for blood lactate concentration and jumping performance [squat jump (SJ) and countermovement jump (CMJ)] before/after RSA. Post-RSA rate of perceived exertion (RPE) was obtained. Receiver operating characteristic analysis was performed to calculate RSA sensitivity and specificity in distinguishing between CH and GH. Intraclass correlation coefficient was used to assess reliability. Results: No baseline differences were found for any variable. &Dgr;SJ before/after RSA was −14 ± 2% and −5 ± 2% in CH and GH, respectively (P < 0.05). &Dgr;CMJ before/after RSA was −15 ± 2% and −7 ± 2% in CH and GH, respectively (P < 0.05). &Dgr;SJ-based and &Dgr;CMJ-based (before/after RSA) area under curve (AUC) resulted in 0.90 ± 0.07 and 0.86 ± 0.09, respectively, with both AUCs differentiating between CH and GH with 77.78% sensitivity and 88.89% specificity. Pooled AUC resulted in 0.88 ± 0.06. Intraclass correlation coefficient was high (0.85/0.97). Conclusions: Repeated sprint ability is a simple, low-cost field test potentially able to assist in clinical decision making for return to sport.
|
2022-12-18T00:12:25.166Z
|
4,625,301 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/JPROC.2018.2791405",
"MAG": "2789029984",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Building sector energy consumption represents a significant fraction of the overall energy consumption in urban communities. While there has been increasing focus on the development of smart environments to support energy savings in urban commercial buildings, the development of smart environments for the residential sector has been less common. Instead, urban residential energy-saving efforts have focused on improving a building’s physical infrastructure, introducing energy-saving appliances, and motivating residents to adopt energy conservation practices. This paper illustrates that creating an affinity between a building resident’s thermal preferences and a building apartment’s unregulated thermal environment represents an alternative means of generating an energy-efficient environment for multi-family, residential buildings. Two years of 15-min interval summer data, obtained from smart cyber-physical systems installed in 310 apartments across two New York City buildings, is used to develop data-enabled (D-E) models of resident thermal preference and unregulated apartment temperatures. Both of these models use a linear mixed-effects approach. The alignment of optimal resident-apartment pairs is then formulated as an integer-programming problem to explore the building energy saving (BES) potential associated with minimizing the difference between unregulated apartment temperature and the residents’ thermal preference based on summer cooling loads. The work shows that the energy saving potential vary with a building’s physical characteristics as well as the variation in residents’ thermal preferences. The work further demonstrates that both the unregulated temperature and the resident’s preferred temperature in a given apartment are not only affected by outside temperature and external relative humidity, but also strongly affected by the apartment’s geographic orientation. For the specific buildings considered, up to 28% cooling energy saving is possible with full alignment. The paper provides all building monitoring data as an open source data set.
|
2022-12-19T01:03:59.824Z
|
152,994,490 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1017/S0022109000023516",
"MAG": "1543333948",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This paper analyzes the effect of limited information and estimation risk on optimal portfolio choice when the joint probability distribution of security returns is multivariate normal and the underlying parameters (means and variance-covariance matrix) are unknown. We first consider the case of limited, but sufficient information (the number of observations per security exceeds the number of securities or the prior distribution of the underlying parameters is “sufficiently” informative). We show that for a general family of conjugate priors, the admissible set of portfolios, taking estimation risk into account, may be obtained by the traditional mean-variance analysis. As a result of estimation risk the optimal portfolio choice differs from that obtained by traditional analysis.
|
2022-12-19T15:22:57.752Z
|
34,923,919 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1177/0962280216666667",
"MAG": "2528301337",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "https://serval.unil.ch/resource/serval:BIB_9B1DB0248B24.P001/REF.pdf"
}
|
Bland and Altman’s limits of agreement have traditionally been used in clinical research to assess the agreement between different methods of measurement for quantitative variables. However, when the variances of the measurement errors of the two methods are different, Bland and Altman’s plot may be misleading; there are settings where the regression line shows an upward or a downward trend but there is no bias or a zero slope and there is a bias. Therefore, the goal of this paper is to clearly illustrate why and when does a bias arise, particularly when heteroscedastic measurement errors are expected, and propose two new plots, the “bias plot” and the “precision plot,” to help the investigator visually and clinically appraise the performance of the new method. These plots do not have the above-mentioned defect and still are easy to interpret, in the spirit of Bland and Altman’s limits of agreement. To achieve this goal, we rely on the modeling framework recently developed by Nawarathna and Choudhary, which allows the measurement errors to be heteroscedastic and depend on the underlying latent trait. Their estimation procedure, however, is complex and rather daunting to implement. We have, therefore, developed a new estimation procedure, which is much simpler to implement and, yet, performs very well, as illustrated by our simulations. The methodology requires several measurements with the reference standard and possibly only one with the new method for each individual.
|
2022-12-30T00:25:11.210Z
|
52,807,175 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1203/00006450-200506000-00048",
"MAG": "2022018917",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://www.nature.com/articles/pr2005188.pdf"
}
|
A retrospective study of 254 hospitalized children with febrile seizure was carried out between January 1998 to December 2002. The mean age of the children was 1.5 years (18 months) the peak age incident was between 0.6 and 1.75 years (7 to 21 months).The male female ratio was 1.16:1. The mean temperature was 39.15 °C with a minimum of 38 °C and a maximal temperature of 41°C. There was a history of birthweight less than 2500 gr in 16 patients (6.3%), positive family history of epilepsy in 14.6% and family febrile convulsions in 10.2%. Simple febrile seizure was seen in 42.1% and complex seizure in 57.9%.Upper respiratory tract infection was the commonest triggering factor diagnosed in 37.4% followed by gastroenterocolitis in 33.5%. Lumbar puncture was done in 55.9%, electroencephalogram in 22.4%, Neuroimaing studies like Computerized Axial Tomography in 7.1% and Nuclear Magnetic Resonance in 0.8%. The most anticonvulsivant drug used during febrile seizure was intravenous diazepam in 40.6%. A 48 % of patients received long term treatment being the most used valproic acid, phenytoin and phenobarbital. The Odds ratio(OR) for complex febrile seizure compared to simple febrile seizure was significative with birthweight less than 2500 gr ( OR 0.31 CI 0.10, 0.91) and anterior seizure episode (OR 2.11 CI 1.15, 3.87)
|
2022-08-24T09:57:52.271Z
|