corpusid
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255M
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dict | abstract
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195,881,595 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/ISDRS.2003.1272033",
"MAG": "2984720969",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In this presentation, a new modeling technique to exactly describe the time-domain (TD) responses of deep sub-micron MOSFETs, which leads to wideband models. This new method is suitable for modeling of MOSFETs used in high-speed or switching type circuits. To meet the wideband requirement without any alteration on the DC bias condition, the equivalent circuit models incorporate BSIM3v3 during the modelling process.
|
2022-02-08T07:29:09.112Z
|
134,972,731 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.7289/V5668B40",
"MAG": "2897169993",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Despite recent efforts to collect high-resolution multibeam bathymetry data across the Pacific Islands Region significant gaps exist in the 0–30 m depth range. Achieving bathymetric coverage in these areas is critical for assessing the health of coral reef ecosystems that reside there. Here we use WorldView-2 multispectral satellite imagery and two depth derivation methods (Lyzenga, 2006; Stumpf et al., 2003) that relate spectral radiance values to ground truth depth information to derive depths for shallow regions in the Main Hawaiian Islands. Our results show increased accuracy using the Lyzenga (2006) multiple linear regression method when compared to the Stumpf et al. (2003) ratio method. Furthermore we achieved improved results by eliminating the linearization process from the Lyzenga (2006) method. This improvement may be related to the lack of large seagrass aggregations within the Main Hawaiian Islands because the presence of seagrass has been shown to affect the linear relationship between ground truth depth and spectral radiance values (Doxani et al., 2012). The accuracy of our derived depth product is directly related to the quality of the multispectral satellite images, the availability of ground truth data, and water depth with accuracy decreasing substantially in water depths >20 m. Our results show that in the absence of shallow (0–20 m) high resolution bathymetric data, satellite-derived depths are an important resource for studying shallow coral reef ecosystems.
|
2022-11-09T18:30:50.609Z
|
42,997,605 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3324/HAEMATOL.11118",
"MAG": "2014089937",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Using a very simple flow cytometry protocol, we found that CD36 and CD117 on granulocytes and CD56 on monocytes were the major bone marrow phenotypic aberrations in patients with myelodysplasia, including CMML. CD56 on monocytes was associated with CMML. Importantly, phenotypic aberrations were lost on blood cells, except for CD56.
|
2022-12-20T20:46:05.536Z
|
12,641,226 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1139/M85-138",
"MAG": "2069504362",
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},
"license": null,
"status": null,
"url": null
}
|
Production of beta-lactam antibiotics took place during growth of Streptomyces clavulgerus in chemically defined medium. The specific activities of isopenicillin N synthetase ("cyclase"), isopenicillin N epimerase, and deacetoxycephalosporin C synthetase ("expandase") increased during the exponential phase of growth. Specific cephalosporin productivity during fermentation followed a similar pattern, reaching a maximum near the end of the growth phase and decaying rapidly in the stationary phase. Ammonium chloride depressed cephalosporin production, presumably as a result of repression of cyclase and expandase formation, but not of epimerase. No inhibitory effects on enzyme activity by ammonium were found. Addition of tribasic magnesium phosphate [Mg3(PO4)2 X 8H2O] prevented the repression of cyclase and markedly stimulated cephalosporin production. Cephamycin C and, in smaller amounts, O-carbamoyldeacetylcephalosporin C were the only cephalosporins detected. Growth with ammonium resulted in lower titers of both compounds, and did not change the relative proportion of each. The correlation found between cephalosporin productivity and cyclase specific activity in different media suggests that formation of this enzyme may be the rate-limiting step in the pathway.
|
2022-12-13T07:22:09.657Z
|
357,193 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3897/zookeys.403.7149",
"MAG": "2003610072",
"PubMedCentral": "4023240"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://zookeys.pensoft.net/article/3763/download/pdf/"
}
|
Abstract The state of Hidalgo (Mexico) is an important region from the point of view of biodiversity. However, there exists a significant gap in accessible knowledge about species diversity and distribution, especially regarding to freshwater ecosystems. This dataset comprises the sampling records of two projects developed in Hidalgo between 2007 and 2009 about the freshwater fish communities of Tecocomulco lake and rivers belonging to the Metztitlán Canyon Biosphere Reserve. It contains the taxonomic identity (species level) and basic biometric data (total length and weight) as well as date of collection and coordinates of more than 9000 specimens. This dataset is the primary result of the first and unrepeated exhaustive freshwater fish’s survey of Metztitlán Canyon Biosphere Reserve and Tecocomulco lake. It incorporates seven more species to the regional fish fauna, and new exclusive biometric data of ten species. This dataset can be used by studies dealing with, among other interests, North American freshwater fish diversity (species richness, distribution patterns) and biometric analyses, useful for the management and conservation of these areas. The complete dataset is also provided in Darwin Core Archive format.
|
2022-12-16T14:41:34.970Z
|
6,276,846 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/02791072.2013.843044",
"MAG": "1836295533",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Abstract Stigma can be harmful to drug users, particularly those in need of treatment. Beliefs and opinions about drug use may influence how individuals view or treat drug users, so research was needed to examine whether specific beliefs and opinions are related to stigma towards users. A sample of 531 adults was assessed to examine how stigmatization relates to specific beliefs and opinions about drug use. Eighty percent of the sample reported lifetime use of an illicit drug. While controlling for demographic characteristics, lifetime drug use and exposure to users, stigmatization towards users more than doubled the odds of reporting that addiction is a choice, and more than tripled the odds for reporting that marijuana and heroin are equally dangerous. Stigmatization, however, lowered the odds of reporting that drugs would be okay to use if legal. Individuals who stigmatize drug users may be under-educated about drug use; however, such individuals appear to be at low risk for use. Beliefs and opinions guided by misinformation may negatively affect users, so public health efforts are needed to educate individuals about drug use and addiction in an objective manner, and treat use as more of a health behavior and less of a moral behavior.
|
2022-12-17T22:52:00.032Z
|
5,246,695 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1210/MEND.14.5.0443",
"MAG": "2080822108",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Bcl-w, a prosurvival member of the Bcl-2 family, is essential for spermatogenesis. However, the mechanisms by which Bcl-w participates in the regulation of apoptosis in the testis are largely unknown. To explore the potential role of Bcl-w in the regulation of apoptosis in the testis, the expression of Bcl-w mRNA and protein during testicular development and spermatogenesis, the dimerization with the proapoptosis members of the Bcl-2 family, and the responses to hormonal stimulation in vitro and apoptosis-inducing signals in vivo were investigated. Both Bcl-w mRNA and protein were detected in Sertoli cells, spermatogonia, and spermatocytes, as well as in Leydig cells. The steady-state levels of Bcl-w mRNA and protein were much higher in Sertoli cells than in spermatogonia and spermatocytes. In the adult rat testis, both Bcl-w mRNA and protein in Sertoli cells displayed a stage-specific expression pattern. Bcl-w could form complexes with Bax and Bak but not with Bad. Bax and Bak were immunohistochemically localized to the same cell types as Bcl-w, but with higher expression levels in spermatocytes and spermatogonia than in Sertoli cells. FSH could up-regulate Bcl-w mRNA levels in the seminiferous tubules cultured in vitro, whereas no effect was observed when testosterone was applied. Three animal models that display spermatogonial apoptosis induced by blockade of stem cell factor/c-kit interaction by a function-blocking anti-c-kit antibody, spermatocyte apoptosis induced by methoxyacetic acid, and apoptosis of spermatogonia, spermatocytes, and spermatids induced by testosterone withdrawal after ethylene dimethane sulfonate treatment were employed to check the changes of Bcl-w, Bax, and Bak protein levels during apoptosis of specific germ cells. In all three models, the ratios of Bax/Bcl-w and Bak/Bcl-w were significantly elevated. The present study suggests that Bcl-w is an important prosurvival factor of Sertoli cells, spermatogonia, and spermatocytes and participates in the regulation of apoptosis by binding proapoptotic factors Bax and Bak. The ratios of Bax/Bcl-w and Bak/Bcl-w may be decisive for the survival of Sertoli cells, spermatogonia, and spermatocytes.
|
2022-12-21T00:22:43.736Z
|
45,950,179 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1590/S1677-04202007000300006",
"MAG": "1983808908",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In this study, the effects of cadmium (Cd) on lipid peroxidation, electrolyte leakage, protein oxidation, ascorbate peroxidase (APX; E.C. 1.11.1.11), catalase (CAT; E.C. 1.11.1.6) and superoxide dismutase (SOD; E.C. 1.15.1.1) activities, and ascorbic acid, non-protein thiol groups and total soluble protein contents in cucumber seedlings (Cucumis sativus L.) were investigated. Seedlings were grown in vitro in an agar-solidified substrate containing four Cd levels as CdCl2 (0, 100, 400, and 1000 µmol L-1) for 10 d. The lowest Cd level decreased the malondialdehyde concentration. Electrolyte leakage increased only at 1000 µmol Cd L-1, whereas protein oxidation and total soluble protein content were enhanced at 400 and 1000 µmol Cd L-1. Activity of APX was inhibited while the activities of CAT and SOD were increased at all Cd concentrations. Ascorbic acid was enhanced at 400 and 1000 µmol Cd L-1 whereas non-protein thiol groups were increased at all Cd supplies. The results evidence the importance of the enzymatic and non-enzymatic antioxidant system in response to cadmium toxicity in cucumber seedlings.
|
2022-12-20T09:18:16.181Z
|
244,773,126 |
{
"externalids": {
"ACL": null,
"ArXiv": "2112.00699",
"DOI": "10.5121/csit.2021.111909",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://doi.org/10.5121/csit.2021.111909"
}
|
The application of Natural Language Processing (NLP) has achieved a high level of relevance in several areas. In the field of software engineering (SE), NLP applications are based on the classification of similar texts (e.g. software requirements), applied in tasks of estimating software effort, selection of human resources, etc. Classifying software requirements has been a complex task, considering the informality and complexity inherent in the texts produced during the software development process. The pre-trained embedding models are shown as a viable alternative when considering the low volume of textual data labeled in the area of software engineering, as well as the lack of quality of these data. Although there is much research around the application of word embedding in several areas, to date, there is no knowledge of studies that have explored its application in the creation of a specific model for the domain of the SE area. Thus, this article presents the proposal for a contextualized embedding model, called BERT_SE, which allows the recognition of specific and relevant terms in the context of SE. The assessment of BERT_SE was performed using the software requirements classification task, demonstrating that this model has an average improvement rate of 13% concerning the BERT_base model, made available by the authors of BERT. The code and pre-trained models are available at https://github.com/elianedb.
|
2022-07-03T04:35:55.716Z
|
143,875,230 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5860/choice.31-6314",
"MAG": "1990261695",
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
Will reading habit influence your life? Many say yes. Reading intervention and detachment essays in legal history and jurisprudence is a good habit; you can develop this habit to be such interesting way. Yeah, reading habit will not only make you have any favourite activity. It will be one of guidance of your life. When reading has become a habit, you will not make it as disturbing activities or as boring activity. You can gain many benefits and importances of reading.
|
2022-09-15T13:09:34.291Z
|
77,671,956 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.18869/ACADPUB.ISMJ.19.2.267",
"MAG": "2465543861",
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},
"license": null,
"status": null,
"url": null
}
|
Background : Besides the role that universities websites have in reflection of universities’ educational and research activities, they have also significant importance in promotion of universities’ national and international ranking in webometrics ranking of world universities and also in webometric ranking of Islamic world Science Citation and subsequently obtaining national and international credibility and gaining student and funding. So, continuous evaluation of universities websites in different aspects, especially based on considering index of these ranking systems, is important. Therefore, present study aimed to review the situation of Type 3 Iranian medical universities’ websites based on content and technical features effecting on promotion of webometric rank. Materials and Methods : Present study is a survey with descriptive approach which descriptive the present situation of Type 3 Iranian medical universities’ websites. Data were collected using a researcher-made checklist which was consisted of two parts including content criteria effecting on webometric ranking (50 criteria) and technical criteria of search engines optimization (52 criteria). Content evaluation of websites was done by researcher direct referring and observing. In order to evaluation of these websites, based on technical criteria of search engines optimization, automatic tools about website evaluation were used. Data were analyzed by SPSS20. Results : The finding of this study showed that, Gonabad, Bushehr & Shahrekord universities of medical sciences have the most accommodation with the research checklist. Bam, Dezful & Jiroft universities of medical sciences have the least accommodation. According to research findings less than 50 percent of the research community, reached more than 50 percent of the criteria in checklist. Conclusion: Evaluation of studied websites indicated that whole websites are far from ideal situation. So type 3 medical universities besides pay more attention to produce of rich and update information content also they must notice to technical criteria of search engines optimization in designing of their websites and by removing the technical access problems, try to eliminate the barriers of visibility.
|
2022-10-29T17:45:10.764Z
|
2,343,931 |
{
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"ACL": null,
"ArXiv": null,
"DOI": "10.1001/archpediatrics.2011.1407",
"MAG": "2112111252",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://jamanetwork.com/journals/jamapediatrics/articlepdf/1151625/poa110049_465_472.pdf"
}
|
OBJECTIVE
To examine associations of television viewing with eating behaviors in a representative sample of US adolescents.
DESIGN
Cross-sectional survey.
SETTING
Public and private schools in the United States during the 2009-2010 school year.
PARTICIPANTS
A total of 12,642 students in grades 5 to 10 (mean [SD] age, 13.4 [0.09] years; 86.5% participation).
MAIN EXPOSURES
Television viewing (hours per day) and snacking while watching television (days per week).
MAIN OUTCOME MEASURES
Eating (≥1 instance per day) fruit, vegetables, sweets, and sugary soft drinks; eating at a fast food restaurant (≥1 d/wk); and skipping breakfast (≥1 d/wk).
RESULTS
Television viewing was inversely related to intake of fruit (adjusted odds ratio, 0.92; 95% CI, 0.88-0.96) and vegetables (0.95; 0.91-1.00) and positively related to intake of candy (1.18; 1.14-1.23) and fast food (1.14; 1.09-1.19) and skipping breakfast (1.06; 1.02-1.10) after adjustment for socioeconomic factors, computer use, and physical activity. Television snacking was related to increased intake of fruit (adjusted odds ratio, 1.06; 95% CI, 1.02-1.10), candy (1.20; 1.16-1.24), soda (1.15; 1.11-1.18), and fast food (1.09; 1.06-1.13), independent of television viewing. The relationships of television viewing with fruit and vegetable intake and with skipping breakfast were essentially unchanged after adjustment for television snacking; the relationships with intake of candy, soda, and fast food were moderately attenuated. Age and race/ethnicity modified relationships of television viewing with soda and fast food intake and with skipping breakfast.
CONCLUSION
Television viewing was associated with a cluster of unhealthy eating behaviors in US adolescents after adjustment for socioeconomic and behavioral covariates.
|
2022-12-16T06:50:55.261Z
|
161,828,713 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4000/crm.12383",
"MAG": "1602974997",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "https://journals.openedition.org/crmh/pdf/12383"
}
|
La delinquance matrimoniale est la version abregee et revue d’une these de doctorat dirigee par Claude Gauvard et soutenue en decembre 2011 a l’universite de Paris I Pantheon-Sorbonne. L’auteur, Martine Charageat (M. C.), y explore les relations entre une institution judiciaire ecclesiastique, l’officialite de Saragosse, et une realite individuelle autant que sociale et culturelle, deux epoux en conflit. M. C. s’appuie essentiellement sur les archives de l’officialite de Saragosse, secondaire...
|
2022-12-30T00:11:54.902Z
|
235,714,627 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3390/antiox10071015",
"MAG": null,
"PubMedCentral": "8300831"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.mdpi.com/2076-3921/10/7/1015/pdf?version=1625194621"
}
|
Previous studies have indicated that curcumin supplementation may be beneficial for cardiometabolic health; however, current evidence regarding the effects of its nanorange formulations, popularly known as “nano-curcumin”, remains unclear. This systematic review and meta-analysis aimed to determine the impact of nano-curcumin supplementation on risk factors for cardiovascular disease. PubMed, Scopus, Embase, and ISI web of science were systematically searched up to May 2021 using relevant keywords. All randomized controlled trials (RCTs) investigating the effects of nano-curcumin supplementation on cardiovascular disease risk factors were included. Meta-analysis was performed using random-effects models, and subgroup analysis was performed to explore variations by dose and baseline risk profiles. According to the results of this study, nano-curcumin supplementation was associated with improvements in the glycemic profile by decreasing fasting blood glucose (FBG) (WMD: −18.14 mg/dL; 95% CI: −29.31 to −6.97; p = 0.001), insulin (WMD: −1.21 mg/dL; 95% CI: −1.43 to −1.00; p < 0.001), and HOMA-IR (WMD: −0.28 mg/dL; 95% CI: −0.33 to −0.23; p < 0.001). Interestingly, nano-curcumin supplementation resulted in increases in high-density lipoprotein (HDL) (WMD: 5.77 mg/dL; 95% CI: 2.90 to 8.64; p < 0.001). In terms of other lipid profile markers (triglyceride (TG), total cholesterol (TC), and low-density lipoprotein (LDL)), subgroup analyses showed that nano-curcumin supplementation had more favorable effects on lipid profiles in individuals with dyslipidemia at baseline. Nano-curcumin supplementation also showed favorable anti-inflammatory effects by decreasing C-reactive protein (CRP) (WMD: −1.29 mg/L; 95% CI: −2.15 to −0.44; p = 0.003) and interleukin-6 (IL-6) (WMD: −2.78 mg/dL; 95% CI: −3.76 to −1.79; p < 0.001). Moreover, our results showed the hypotensive effect of nano-curcumin, evidenced by a decrease in systolic blood pressure (SBP). In conclusion, our meta-analysis suggests that nano-curcumin supplementation may decline cardiovascular disease risk by improving glycemic and lipid profiles, inflammation, and SBP. Future large-scale investigations with longer durations are needed to expand on our findings.
|
2022-12-25T23:03:19.462Z
|
145,374,216 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.1037/0022-3514.59.2.202",
"MAG": "2125854125",
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},
"license": null,
"status": null,
"url": null
}
|
Two experiments examined the hypothesis that the sequence of affect and cognition in an attitude's formation is an important determinant of its subsequent resistance to affective and cognitive means of persuasion. Affect-based and cognition-based attitudes were induced and subsequently challenged by either affective or cognitive means of persuasion. The procedure used to create the 2 types of attitudes and the means of persuasion involved varying the sequence of affect and cognition while holding the content of communications constant. As predicted, affect-based attitudes exhibited more change under affective means of persuasion than under cognitive means of persuasion. Cognition-based attitudes, on the other hand, exhibited equal change under both forms of persuasion. The interaction between attitude type and means of persuasion emerged both when affect was manipulated subliminally (Experiment 1) and when affect was manipulated supraliminally (Experiment 2). Moreover, in the 2nd experiment, affect-based attitudes were expressed with greater confidence than their cognition-based counterparts. Together, these findings underscore the theoretical as well as practical importance of distinguishing between affect- and cognitionbased attitudes and, more generally, the need for influence attempts to make contact with an attitude's origin. Whether in the form of education or propaganda, whether the desired end is virtuous or evil, persuasion plays a central role in social behavior. Parents and teachers use persuasion to instill appropriate attitudes in young people and to modify attitudes they consider inappropriate. Members of social groups rely on persuasion to gain representation and recognition. Spiritual, intellectual, business, and social leaders assert their strength and maintain a following in large part through persuasive efforts. And participants in a democracy are keenly aware of the important role persuasion and oratory play in the decision making of legislators. Yet two questions remain equivocal: What constitutes the best method of persuasion? And why do some persuasive attempts fail on one occasion and succeed on another? The Platonic ideal of persuasion emphasizes the exercise of reason and places a premium on skills of oration. This theme underlies a substantial body of empirical work on attitude change, much of which has its origins in the Yale Communication Research Program (Hovland, 1949; Hovland, Janis, & Kelley, 1953). According to this perspective, acceptance of a persuasive message is dependent on the existence of incentives, and a critical incentive "is provided by arguments or reasons which. . . constitute 'rational' or 'logical' support for the con
|
2023-01-01T18:43:03.860Z
|
29,632,763 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5220/0003006504030412",
"MAG": "1556548830",
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
Generally software model developers use a general purpose language such as Unified Modelling Language (UML) in modelling their domain application models. But when they come to the situation in which the models they create do not perfectly fit the modelling needs as they desire, a more specific domain modelling language offers a better alternative approach. In this paper, we create a Disaster Management (DM) metamodel that can be used to create a disaster management language. It will serve as a representational layer of DM expertise leading to a DM decision support system based on combining and matching different DM activities according to the disaster on hand. A creation process of the metamodel is presented leading to the synthesis of initial metamodel, as a main component to create a decision support system to unify, facilitate and expedite access to DM expertise.
|
2022-12-15T22:44:02.014Z
|
13,465,037 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1117/12.631566",
"MAG": "2049094109",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
To get high compress efficiency, the latest H.264/AVC international video coding standard introduced many more advanced tools than previously used standards, such as using sophisticated prediction and rate-distortion (RD) mode selection. Although these new coding tools can significantly improve video coding efficiency, the improvement in performance comes at substantially higher computational complexity as a result of more complicated mode decision. To reduce the complexity of H.264 encoding, various fast mode decision algorithms have been proposed. Many of these algorithms take advantage of motion and video content classification so as to reduce the number of modes tried during mode decision. When used for video sequences with high motion or detailed visual information, video coding e±ciency can be significantly compromised as a result of imperfect classification. In this paper, an efficient Probability Based Macroblock Mode Selection (PBMMS) algorithm is proposed. Each MB is predicted to different probability MB based on spatial and special correlation, which then leads to 50-60% computation savings and some compression performance improvements over existing H.264 fast mode decision algorithms.
|
2022-12-16T21:06:46.619Z
|
28,402,684 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/HICSS.2005.42",
"MAG": "2163162780",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The idea of anywhere and anytime learning is enticing. Electronic-based learning is seen as an answer to this requirement. Currently there are many variations in electronic-based instructional media, and there is little research to determine which format or combination of formats is most conducive to facilitating knowledge transfer and learning. This research project explores three primary constructs of media richness, content flexibility, and forced engagement, in relation to effectiveness or productivity in facilitating learning in the experimental participants. The instructional subject matter was detecting deceptive communication
|
2022-12-17T22:11:19.872Z
|
12,800,767 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/ppe.12058",
"MAG": "1934915055",
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},
"license": null,
"status": null,
"url": null
}
|
BACKGROUND
Recent studies suggest that children born at late preterm (34-36 weeks gestation) and early term (37-38 weeks) may have poorer developmental outcomes than children born at full term (39-41 weeks). We examined how gestational age is related to cognitive ability in early childhood using the U.K. Millennium Cohort Study.
METHODS
Cognitive development was assessed using Bracken School Readiness Assessment at age 3 years, British Ability Scales II at ages 3, 5 and 7 years and Progress in Mathematics at age 7 years. Sample size varied according to outcome between 12,163 and 14,027. Each gestational age group was compared with the full-term group using differences in z-scores and risk ratios for scoring more than -1 SD below the mean.
RESULTS
Children born at <32 weeks gestation scored lower (P < 0.05) than the full-term group on all scales with unadjusted z-score differences ranging between -0.8 to -0.2 SD. In all groups, there was an increased risk (P < 0.05) of scoring less than -1 SD below the mean compared with the full-term group for some of the tests: those born at < 32 weeks had a 40-140% increased risk in seven tests, those born at 32-33 weeks had a 60-80% increased risk in three tests, those born at 34-36 weeks had a 30-40% increased risk in three tests, and those born at 37-38 weeks had a 20% increased risk in two tests.
CONCLUSIONS
Cognitive ability is related to the entire range of gestational age, including children born at 34-36 and 37-38 weeks gestation.
|
2022-12-18T23:36:18.638Z
|
170,445,644 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.5840/jphilnepal20094915",
"MAG": "2199683587",
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},
"license": null,
"status": null,
"url": null
}
|
Y. A.: Giambattista Vico points out that the degeneration of the senses began to take place with the birth of reason in ancient Greece. This degeneration is further accelerated with the rise of modern science and its cultural logic. We have been continuingly losing the sensibility of our ancestors, who could imagine a universe in a grain of sand, who could respond the language of nature, for whom everything was intelligible in terms of Jove. But now everything is intelligible merely in terms of political, economic, psychological and linguistic units; our sensibility is divided into so many units. Do you not think it is the degeneration of our senses? [ILLUSTRATION OMITTED] S. S.: It seems to be part of the heritage of Platonism that we set up the senses in opposition to the reason, and Vico turns this philosophical position into a kind of [hypothetical] historical fact. At the same time, there is undoubtedly some truth in the idea that rationality spares us a great deal of impulsive action [and fear!] and new tools mediate our relation to the sensual world-but do our senses "degenerate" in consequence? How would we know? I'm not sure that we have lost the sensibility of imagining a universe in a grain of sand-after all, you have pictured the universe in a grain of sand in your question and this seems to me to be more a matter of using the imagination than knowing well the actuality of a sand grain. I am sure I don't find the world intelligible, as you suggest, according to discrete "units," or even according to scientific method. Intelligibility strikes me as an ongoing synthesis in which the senses have a primary role. Perhaps we in contemporary Western societies do not see nature as a "language"-that is, as organized at a coherent, sacred, level of signification-but certainly most of us respond to nature-even at the most rudimentary level, with a kind of biophilia. Living things call out to other living things. Y. A.: In art, the degeneration of senses is clearly visible. Our heroes (even though whether they can be called heroes or not is debatable) like Gregor Samsa, Willy Lowman and the like in modernist literature, unlike Jove, Prometheus and Achilles (possessed with enormous vitality and power) are reduced to mere social, political, economic and psychological units. In a context where our poets are reduced to socio-cultural linguistic units, their intimacy with the natural world is replaced by their relationship with the machine. Their 'tactile senses' neither smell/touch the 'clay' nor communicate with the Zove. In a culture, as you pointed out in your book Poetry and the Fate of the Senses, in which the "entire spheres of sense experiences" are gone and "even their names will be soon gone," what changes took place and what not in our senses when we traveled from Zove through Prometheus down to Willy Lowman? Where do you locate the roots for the ill-fate of our senses? S. S.: I would think that protagonists who are victims of absurdity, mechanization, or anomie, are of interest to us because they remain the exception and call for our sympathy-a sympathy that continues to exist in the world of literature, of readers and writers, regardless of those economic forces, or state powers, or social demands for conformity that are wreaking havoc upon such characters. Although certain kinds of speed are synonymous with ecstasy, and could in fact be considered to be heightened instances of sense experience, I was concerned in the conclusion of my book with the promulgation of speed for its sake. And I was worried even more deeply about the related practice of reducing natural phenomena to objects or things for use only. I saw these problems as a pervasive development and not located in one milieu more than others. Nor do I consider our sensibility to be "degenerated." Imagining the tragedy of Willy Loman seems to me to be a more complex and interesting task than picturing Jove, who, after all, reciprocally represents those forces of nature that are his attributes. …
|
2022-07-09T04:25:09.340Z
|
252,862,142 |
{
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"ACL": null,
"ArXiv": null,
"DOI": "10.1155/2022/1329653",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "https://downloads.hindawi.com/journals/mpe/2022/1329653.pdf"
}
|
In all types of topological indicators, degree-based indicators play a major role in chemical graph theory. The topological index is a fixed numeric value associated with graph isomerism. Firstly, in 1972, the concept of degree-based index was developed by Gutman and Trinajstic. These degree-based indices are divided into two ways, namely, degree and connection number. These degree-based graph indices are positive-valued for non-regular graphs and zero for regular graphs. In this article, we discussed the degree-based Sombor, reduced Sombor, and average Sombor indices for wheel graph, gear graph, helm graph, flower graph, sunflower graph, and lobster graph.
|
2022-10-14T15:16:15.365Z
|
133,718,934 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2307/1595967",
"MAG": "2799442811",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
One day, you will discover a new adventure and knowledge by spending more money. But when? Do you think that you need to obtain those all requirements when having much money? Why don't you try to get something simple at first? That's something that will lead you to know more about the world, adventure, some places, history, entertainment, and more? It is your own time to continue reading habit. One of the books you can enjoy now is the history al tabari general introduction and from the creation to the flood here.
|
2022-12-17T09:37:55.933Z
|
156,164,837 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2139/SSRN.2594671",
"MAG": "2342152182",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A literature is rapidly developing on financial shocks originating from ecological imbalances. These shocks can be triggered by either intensified environmental policies, clean tech breakthroughs or due to the economic costs of crossing ecological boundaries. However, financial supervisors have so far given little attention to this ecological dimension. This allows systemic financial imbalances resulting from ecological pressures to build up and concentrate in financial institutions and markets. This paper sketches the ecological dimension of the prudential policy framework and illustrates the working for the case of carbon emissions.
|
2022-12-21T15:07:00.191Z
|
165,727,660 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3989/SEFARAD.018.0012",
"MAG": "2909356265",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Las páginas siguientes abordan la identidad literaria de Joseph de la Vega, quien compone en español su diálogo Confusión de confusiones publicado en la diáspora holandesa. Además de las connotaciones específicamente judaicas, el sefardismo del escritor afincado en Ámsterdam condiciona la elección del idioma y la herencia conceptista de su estilo, que mantiene recuerdos evidentes de la cultura hispánica, así como la forma del diálogo utilizada puede inscribirse en la tradición del género dialogado cultivado en la literatura española. Se produce, por tanto, una curiosa mezcla en la identidad de su escritura, surgida en un ámbito de cruces culturales que excede los habituales límites marcados por cada historiografía nacional.
|
2022-12-30T00:22:22.784Z
|
198,334,589 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3844/JMRSP.2019.82.101",
"MAG": "2955663357",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Classical distribution is the most used in rigid memory mechanisms adapted to four-stroke internal combustion engines such as Otto or diesel, as it was designed by Otto more than 150 years ago, without essential changes from its conception and up today. Since it was not yet possible to introduce the electric car to the industrial scale and today we have these classic cars with their distribution still in operation, with a park that exceeds a billion cars and grows annually by another 70 million units. If we only take into account these aspects without taking into account the classical rigid mechanisms used in robotics and mechatronics, mechanical transmissions, automated processing machines, or medical devices and we are talking about a scale utilization billions of pieces, so it is justified to continue discussing how these mechanisms work and especially their dynamics, in order to permanently improve them to eliminate the noises and vibrations of these mechanics, but also to increase their power and reduce consumption motor fuel still equipped with classic engines.
|
2022-06-28T21:05:55.672Z
|
84,506,953 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/09670879309371779",
"MAG": "2028783388",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Abstract Macadamia quick decline (MQD) refers to a problem of quick death of macadamia trees (Macadamia integrifolia Maiden and Betche). The death often occurs within 8 months after first observing symptoms of decline. Female Xyleborus beetles [75% X. perforans (Wollaston), 23% X. affinls Eichoff, and 2% X. ferrugineus (Fabricius)] were found emerging from beetlebored holes on tree trunks showing MQD symptoms. These beetles attacked 68% of the symptomless, live, mature test trees. Cultivars 294 and 660 were less attacked by the beetles than other cultivars. The beetles were caught in an orchard using 20‐cm diameter, white, multiple‐funnel traps with a 95% ethanol attractant. The peak population in the test area occurred in October when the average daily catch was 90 beetles. Male and female parasitoids were found emerging from adults of X. perforans. Of the 336 beetles collected, 15% were parasitized.
|
2022-08-20T11:51:26.629Z
|
10,580,127 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1067/mjd.2000.105166",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
We describe a new occupation-related skin finding in 2 computer programmers and discuss its characteristics and causes.
|
2022-09-05T22:02:20.576Z
|
8,222,414 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/CICT.2013.6558287",
"MAG": "2013846467",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Eliminating the conflict misses in the caches has been a foremost field of research in cache memories. Although several cache addressing/indexing techniques have been demonstrated, most of them discuss about eliminating conflict misses for various memory access strides in a solo cache system. In this paper we present the analysis of the scenarios where conflicts arise at different levels of caches in a multilevel cache system. In this paper, we propose two block placement schemes least-XOR and full-XOR for multi-level caches. These placement strategies reduce the scenarios where two addresses conflict with each other at multiple places in multi-cache system and thus improves the global miss rates which are fairer indicator of performance than the local miss rate. These schemes do not require any additional hardware to the existing indexing hardware on the chip. We evaluate these schemes on sixteen memory intensive spec2000 benchmarks and show that there is a significant improvement over the traditional scheme for various performance measures such as cache miss rates, memory traffic, and CPI reductions. These schemes can achieve about 10-20% reduction in L2 and L3 cache miss rates.
|
2022-09-13T16:06:16.254Z
|
251,696,389 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3390/s22166180",
"MAG": null,
"PubMedCentral": "9415491"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.mdpi.com/1424-8220/22/16/6180/pdf?version=1660812824"
}
|
An antenna assumes a significant role in expanding the levels of communication to meet the demands of contemporary technologically based industry and private data services. In this paper, a printed compact meander line patch antenna array for wireless local-area network (WLAN) applications in the frequency span of 2.3685–2.4643 GHz is presented. The impedance matching of the antenna is generated by applying a partial rectangular-shaped ground plane backside of the meander line antenna. The proposed antenna evolved on the Rogers RT5880 substrate with a dielectric permittivity of 2.2, and the height of the substrate was 1.575 mm to accomplish the lowest possible return loss. The proposed antenna was developed to achieve particular outcomes, for example, voltage standing wave ratio (VSWR) 1.32, reflection coefficient 20 dB with a bandwidth of 94.2 MHz, a gain of 2.8 dBi, and an efficacy measurement of 97%. This antenna is appropriate for WLAN applications that utilize a 2.4 GHz resonance frequency. The overall dimensions of the antenna are 15 mm × 90.86 mm.
|
2022-11-20T14:24:16.800Z
|
138,626,882 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1061/(ASCE)MT.1943-5533.0001456",
"MAG": "2231430787",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
AbstractRecently, ultra-high performance concrete (UHPC) has been utilized in highway bridge connections, where its superior strength and durability help to reduce joint cracking and enhance transverse load transfer. According to the load and resistance factor design (LRFD) bridge design procedure specified by AASHTO, the strength of the connections is dependent on the adhesion and friction between the connected materials. The objective of the present research is to identify the adhesion value between UHPC and high-strength concrete (HSC) with varying degrees of roughness. To this end, UHPC-HSC specimens were tested in direct tension according to ASTM protocols, and the maximum tensile stress at failure was obtained. Test results show that the average maximum tensile stress for the UHPC-HSC specimens with a smooth interface exceeds that determined from past research for any degree of roughness. Furthermore, the average maximum tensile stress increases with the degree of roughness. The results from the dir...
|
2022-12-22T17:58:10.183Z
|
71,938,909 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1001/ARCHINTE.1959.00270080167026",
"MAG": "2046966150",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Admitting that he has not written a complete treatise on pneumoconiosis, Dr. Pendergrass has collected his thoughts on certain aspects of the problem which have interested him. On these topics, he gives us much valuable information. As a radiologist, his knowledge and interest have been unique. The roentgenologic manifestations of pneumoconiosis are dealt with in length and detail. The difficulties and deficiencies in radiographic diagnosis are discussed, and classifications are advanced and criticized. Problems of high clinical import, such as the relationship between pneumoconiosis and other lung disease—notably, tuberculosis, the assessing of disability, the correlation of x-ray appearance with lung function, and the modifications in the radiograph during the life history of the disease, are also well covered. No mention, however, is made of the lung lines described by British writers as occurring from lymphatic blockage in pneumoconiosis. Pneumoconiosis is a problem of importance, but we can not agree to
|
2022-02-11T10:19:04.346Z
|
31,398,594 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1049/sej.1989.0025",
"MAG": "2164274045",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Software engineering is not taught as a separate subject, but the theme runs throughout the three years of the computer science degree programme. The students start with an introduction to the software development lifecycle and project management through a small-group project in the second term of the first year, and by the end of their three years' study have gained understanding and insight into a variety of tools and methods.
|
2022-03-07T15:40:47.437Z
|
96,674,172 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/01418639408241800",
"MAG": "2046115183",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Abstract Neutron diffraction and magic angle spinning (MAS) 27Al and 29Si NMR have been applied to study the local structure of glasses in the system Y-Al-Si-O with and without addition of AlN. 27Al MAS NMR indicated that in the Y-Al-Si-O-N oxynitride glass there is no Al-N bonding and aluminium atoms occupy various sites within the glass structure. The first peak of the radial distribution function curves obtained by neutron diffraction was deconvoluted into four peaks which are attributable to Si-O, Si-N(Al-O(4)), Al-O(5) and Al-O(6) pairs and the coordination numbers of Si, N, Al and Y were estimated. The glass network is assumed to consist mainly of corner-sharing AlO4 tetrahedra and SiO3N tetrahedra. 86% of N atoms are three-coordinated and 14% of N atoms are two-coordinated in the present oxynitride glass.
|
2022-07-30T05:26:17.575Z
|
6,294,907 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5120/1298-1797",
"MAG": "2103251215",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://doi.org/10.5120/1298-1797"
}
|
The mobile adhoc network (MANET) requires effective intrusion response system. In this paper, we present an intrusion response system that supports the infrastructureless nature of MANETs. We propose a NHELLO and Link Layer based solution towards excluding malicious node which is robust against address spoofing from the attacker. In particular, we investigate how power adaption can be used to keep a malicious node away from normal node’s transmission range. Important issue in this strategy is to select optimal transmission power so that malicious node goes out of operating zone of network, as well as node adapting power itself remains in the operating zone. We also provide a detailed performance evaluation based on various network parameters i.e. a series of simulation studies. Our results show that the proposed concept significantly improves the overall security of mobile ad hoc network without having geographical information of nodes.
|
2022-09-02T06:51:07.664Z
|
222,452 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/jgm.596",
"MAG": "2048868036",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Human papillomavirus type 16 (HPV16) E7 is an unstable oncoprotein with low immunogenicity. In previous work, we prepared the E7GGG gene containing point mutations resulting in substitution of three amino acids in the pRb‐binding site of the HPV16 E7 protein.
|
2022-12-13T11:48:18.514Z
|
49,188,864 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/RISE.2017.8378177",
"MAG": "2808526160",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Image enhancement means to enrich the perception of images for human viewers. Image fusion is performed on many schemes. DWT is the most generally used image fusion method, which fuses the source pictures or images in wavelet space as maintained by some fusion rules. But, because of the uncertainties of the source images contributions to the fused image, to intend a good fusion rule to fit in however much data as could reasonably be expected into the fused picture turns into the most vital issue. On the other hand, AFL is the most ideal approach to determine uncertain issues, A new image fusion technique based on DWT and adaptive fuzzy logic is introduced in this paper. Before doing Discrete wavelet transform to source images, it computes the weight of each source images coefficients through AFL and then fuses the coefficients through weighted averaging with the processed weights to acquire a combined picture. By using the Mean Square Error (MSE) as criterions, simulation results would demonstrate that the new method is more effective and strong than the conventional fusion methods based on wavelet transform.
|
2022-12-17T16:30:26.289Z
|
9,201,570 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1098/rspb.1993.0003",
"MAG": "2040896764",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The effects of monocular deprivation done during the critical period are usually ascribed to competition between the two sets of monocular thalamic afferents taking place at cortical level. We have suggested that loss in competition for the deprived eye is explained by the lack of a neurotrophic factor, produced in the cortex and dependent on electrical activity. To test this hypothesis we have exogenously supplied nerve growth factor (NGF) to rats monocularly deprived (MD) during the critical period, and studied whether monocular deprivation still affected the functional and anatomical organization of the visual cortex. NGF is produced in the rat visual cortex during the critical period, and its expression, at least in the hippocampus, seems to be regulated by electrical activity. Ocular dominance distribution of area 17 neurons, visual acuity, and Parvalbumin immunoreactivity (Parva-LI) were determined in four sets of animals: normal rats, control untreated monocularly deprived rats, deprived rats treated with cytochrome c (to control for non-specific aspects of NGF treatment), and deprived rats treated with NGF. Parva-LI is an excellent marker for the effects of monocular deprivation on the functional organization of the rat visual cortex. We found that exogenous supply of NGF completely prevented the shift in ocular dominance distribution of visual cortical neurons, the loss of visual acuity for the deprived eye, and the strong reduction in Parva-LI induced by monocular deprivation in control rats.
|
2022-12-19T13:06:14.255Z
|
180,546,753 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5985/JEC.14.25",
"MAG": "2318948398",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
PCB, PCDD, PCDFの異性体濃度あるいは組成について, 1) 異性体間の濃度差が明らか, 2) 試料間の比較が容易, 3) 化学構造との対応が容易, そして, 4) コンパクトに表現できる, 新規の表現法を提案した。本表現法を環境試料に適応したところ, PCB, PCDD, PCDFの環境中での動態を考えたとき, PCBにおいては2, 4, 5位の塩素置換が, PCDD/Fでは6, 8位塩素置換及び7, 8位塩素置換がキーとなる構造であると考えられた。
|
2022-02-08T13:26:40.907Z
|
56,229,763 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2139/SSRN.2622139",
"MAG": "2414757891",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The coordinating council of legal affairs of executive systems has been established in line with government micro economic policy and for the creating and strengthening of necessary substructures for the more incorporative province legal union in decision making and terms and conditions in the coordinating council framework. The main question is that "who composed and what the aim of coordinating council of legal affairs of executive systems." And the hypothesis arising from this question is that "coordinating council of legal affairs of executive systems consists of governor and representative of legal president vice and planning deputy governing and work in order to dispute resolution among executive systems." The method used in this article is descriptive-analysis and for more investigation, search within legal books and papers and also journals and websites have been used through library method and taking notes. In fact, we can say that the coordinating council of legal affairs of executive systems, in addition to create Precedents, collect and coordinate legal opinions of systems release in legal websites, deal with dispute resolving among the systems in province and terms and conditions framework.
|
2022-02-11T19:31:43.872Z
|
132,639,866 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.33795/jip.v4i1.144",
"MAG": "2933503655",
"PubMedCentral": null
},
"license": "CCBYNC",
"status": "GOLD",
"url": "http://jip.polinema.ac.id/ojs3/index.php/jip/article/download/144/130"
}
|
Dalam pembuatan tempe di pengaruhi oleh banyak hal terutama dipengaruhi oleh perubahan cuaca . Pada cuaca dingin, tempe biasanya ditutupi dengan kain atau penutup lain agar suhu fermentasi tempe tetap stabil sehingga proses fermentasi tempe dapat berlangsung secara normal. Tetapi dengan cara ini ,produsen tempe tidak mengetahui berapa suhu dan kelembabannya. Dengan berkembangnya teknologi mikrokontroler saat ini dibutuhkan suatu alat yang dapat mendeteksi suhu dan kelembaban, Sistem pengendalian sangat diperlukan di dalam dunia industri untuk menghasilkan produk yang bagus maka diperlukan suatu sistem pengendalian yang stabil. Pada alat ini pengontrolan sistem dilakukan oleh Mikrokontroler Arduino UNO yang mempunyai input berbentuk sensor sht11, sensor ini akan mendeteksi suhu dan kelembaban yang berada dalam Inkubator dan menampilkannya pada LCD dan memonitoring melalui SMS Gateway. Inkubator menggunakan sebuah Lampu yang berfungsi sebagai pemanas dengan cara kerja mengeluarkan panas pada Inkubator, dan menggunakan 4 buah tombol setting yang berfungsi sebagai pengatur suhu dan kelembaban. Pengaturan batas suhu dan kelembaban di atur didalam program juga dapat di ubah menggunakan tombol yang ada di mikrokontroler.
|
2022-06-06T04:57:01.449Z
|
80,337,841 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1200/JCO.2016.34.15_SUPPL.536",
"MAG": "2702480815",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
536Background: Classifications for CYP2D6 phenotypes are established for debrisoquine, sparteine and codeine, but not for tamoxifen. CYP2D6 protein activity can be inferred from the ratio of N-desmethyl-tamoxifen (NDMT) to endoxifen (EDF). CYP2D6polymorphisms are common and can affect CYP2D6 protein activity and EDF level. Retrospective analyses of two breast cancer studies indicate that EDF levels below 15nM may relate to worse outcome. Methods: A target NDMT/EDF ratio was defined as that which was associated with an EDF level of 15nM in 108 Australian tamoxifen-treated patients (pts), dichotomizing the group into ‘Normal’ (NM) and ‘Slow’ CYP2D6 metabolizer groups (SM). Pts were classified according to genotype based on Crews et al Clin Pharmacol Ther 95, 376, 2014 (ultrarapid/extensive, intermediate or poor metabolizers; UM/EM, IM, PM) or a simplified system based on whether anyvariant allele was present. The following alleles were measured: *2, *3, *4, *5, *6, *8, *9, *10, *14, *17, *39, *41, 1N and 2N...
|
2022-07-04T11:00:25.054Z
|
8,517,629 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1145/1183614.1183771",
"MAG": "2028838214",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Several information organization, access, and filtering systems can benefit from different kind of document representations than those used in traditional Information Retrieval (IR). Topic Detection and Tracking (TDT) is an example of such an application. In this paper we demonstrate that named entities serve as better choices of units for document representation over all words. In order to test this hypothesis we study the effect of words-based and entity-based representations on Story Link Detection (SLD) - a core task in TDT research. The experiments on TDT corpora show that entity-based representations give significant improvements for SLD. We also propose a mechanism to expand the set of named entities used for document representation, which enhances the performance in some cases. We then take a step further and analyze the limitations of using only named entities for the document representation. Our studies and experiments indicate that adding additional topical terms can help in addressing such limitations.
|
2022-09-10T21:11:16.911Z
|
209,270,269 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3969/j.issn.1674-3466.2009.04.003",
"MAG": "113911394",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Cell cycle regulation is closely linked to plant growth and development. The plant cell cycle responds rapidly to stimuli from both the internal and external environment. We present a model of partially synchronized root tips of Arabidopsis to study the effects of UV-B radiation on the G1/S transition in the cell cycle. Analysis of the fluorescence image under microscopy indicated that G1/S arrest was induced by UV-B radiation. The expression of two factors of G1/S transition, Histone H4 and E2Fa, was repressed under UV-8 radiation, whereas the negative factor of G1/S transition, KRP2, was upregulated by UV-B radiation. UV-B radiation during the cell cycle induced accumulation of cyclobutane pyrimidine dimers. All these results suggested that UV-B-induced plant growth inhibition may be mediated by cell cycle regulation and DNA damage.
|
2022-09-12T07:36:34.997Z
|
103,654,739 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/00084433.2017.1350391",
"MAG": "2735186147",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
ABSTRACT The extraction of precious metals from tellurides by cyanidation is more difficult than when they are in their native form, nevertheless the reason for their refractory nature has not been adequately supported. In this study, the mechanism of the cyanidation kinetics of silver telluride (Ag2Te) was investigated. For this purpose, cyanidation experiments were carried out to: (1) study the difference between the cyanidation kinetics of elemental silver and silver telluride; (2) study the effect of temperature (i.e. 20, 25, 27, 30, 35 and 40°C) on silver telluride dissolution; and (3) elucidate the kinetic mechanism of the silver telluride cyanidation. The results obtained showed that: (1) while 83.5% of elemental silver was dissolved in 8 h, only 13.2% of silver from silver telluride was dissolved in the same time; (2) temperature has an important effect on silver extraction from silver telluride, but a minor effect on tellurium dissolution; and (3) at temperatures between 20 and 27°C, the process was controlled by the chemical reaction with an apparent activation energy of 191.9 kJ mol−1, whereas at temperatures between 30 and 40°C, the process was controlled by diffusion through a Ag5Te3 layer of products with an apparent activation energy of 25.2 kJ mol−1.
|
2022-09-30T16:00:02.722Z
|
235,345,468 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1089/heq.2020.0125",
"MAG": null,
"PubMedCentral": "8175255"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://doi.org/10.1089/heq.2020.0125"
}
|
Objective: The purpose of the study was to understand cervical cancer screening and prevention practices of refugee women in San Diego, California and identify desired components of a cervical cancer screening toolkit. Methods: We conducted a qualitative study utilizing semi-structured focus groups and identified common themes via grounded theory analysis. Results: There were 53 female refugee participants from Sub-Saharan Africa and the Middle East. Over half of all women surveyed expressed a fear of pelvic exams and loss of modesty as barriers to seeking gynecologic care, with nearly 34% avoiding routine pap tests. Of the 18 participants who were asked if they were aware of the Human Papilloma Virus (HPV) vaccination, only one had heard of the vaccine and none had received it for themselves or their children. Over 60% of participants were interested in educational materials surrounding HPV and pap tests. Conclusion: There is a significant lack of knowledge regarding cervical cancer screening and HPV vaccination among refugee women in San Diego, California. Refugee women in this study were interested in multi-modal educational materials as part of a cervical cancer screening toolkit.
|
2022-12-12T03:21:44.082Z
|
246,428,354 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2196/29230",
"MAG": null,
"PubMedCentral": "8844984"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://jmir.org/api/download?alt_name=resprot_v11i1e29230_app1.pdf&filename=19d9eafd3644c8dbc314c104642cc16b.pdf"
}
|
Background Since the introduction of antiretroviral therapy (ART), the incidence of HIV-associated dementia has drastically fallen. Despite using ART, people living with HIV continue to experience less severe but limiting forms of HIV-associated neurocognitive disorder (HAND). People living with HIV who are on ART and experiencing symptoms of HAND may benefit from aerobic exercise. Objective This protocol describes a randomized controlled trial designed to determine the effects of a 12-week aerobic exercise program on HAND in Southeastern Nigeria. Methods At least 68 patients diagnosed with HAND will be randomly placed into either an aerobic exercise group or control group. Patients in the aerobic exercise group will perform a moderate intensity workout on a stationary bicycle ergometer, 3 times a week for 12 weeks. We will measure the primary outcomes including neurocognitive performance, prevalence of HAND, viral load, and CD4 count. We will evaluate postexercise neurocognitive performance using reliable neuropsychological tests relevant to people living with HIV, in line with the Frascati criteria. We will assess secondary outcomes such as quality of life, activity limitation, and social participation using the World Health Organization Quality of Life (WHOQOL)-Brief, and the Oxford Participation and Activities questionnaire. We will use exploratory statistics to test the data for normality and homogeneity. We will analyze the effect of the exercise program on HAND using relative risk (RR) and absolute risk reduction (number needed to treat). Analysis of covariance will be run to estimate the effect of exercise on quality of life and activity and participation level. Results This funded trial was approved by the Institutional Review Board in May 2020. The protocol was approved on June 15, 2020. Enrollment commenced in January 2021 and was completed in May 2021. Over 60% of the participants were recruited at the time of first submission to JMIR Mental Health. Data curation is still ongoing; hence, data analysis is yet to be executed. Study outcomes are expected to be published in March 2022. Conclusions This is a protocol for a randomized controlled trial that aims to evaluate the effect of a 12-week aerobic exercise program on HAND in Southeastern Nigeria. Trial Registration Pan African Clinical Trials Registry PACTR202009483415745; https://tinyurl.com/2p97zpu9 International Registered Report Identifier (IRRID) PRR1-10.2196/29230
|
2022-12-12T02:10:52.212Z
|
37,191,680 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5220/0003637304060412",
"MAG": "2396154691",
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
Classification of dialogue acts constitutes an integral part of various natural language processing applications. In this paper, we present an application of this task to Urdu language online multi-party discourse. With language specific modifications to established techniques such as permutation of word order in detected n-grams and variation of n-gram location, we developed an approach that is novel to this language. Preliminary performance results when compared to baseline are very encouraging for this
|
2022-12-17T09:31:55.161Z
|
122,053,593 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/23.322847",
"MAG": "2137669469",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The suitability of an Si-SSD as a detector for high energy X-ray CT has been investigated. Two types of Si-SSDs which can take the place of ordinary scintillation detectors were proposed. Their predicted responses were compared with that of a CWO scintillation detector of almost the same dimensions by using the EGS4 Monte Carlo simulation code. The sensitivities of the sole-silicon detector and the metal-sandwiched detector were about ten times higher than that of the CWO scintillation detector at X-ray energies above 1 MeV. The metal-sandwiched detector was judged more useful than the sole Si-SSD when the width of the X-ray beam was less than about 0.2 mm. The silicon detector for high energy X-ray CT was fabricated and actual measurements of the depletion layer width and the electronic noise contribution were made. >
|
2022-12-20T08:38:58.968Z
|
22,227,088 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/j.1442-2042.2005.01134.x",
"MAG": "2086083726",
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
Abstract We report here a case of combined small cell carcinoma and sarcomatoid squamous cell carcinoma in the renal pelvis. A 61‐year‐old female presented with right flank discomfort, microhematuria and progressive renal dysfunction. Following diagnosis of right renal pelvic carcinoma, radical nephroureterectomy with lymph node dissection was performed through a midline incision. The tumor was pathologically diagnosed to be combined small cell carcinoma and sarcomatoid squamous cell carcinoma in the renal pelvis. The patient had no evidence of recurrence or metastasis, 16 months postoperatively. Small cell carcinoma or sarcomatoid squamous cell carcinoma of the renal pelvis is very rare. We believe this is the first such case to be reported in the world.
|
2022-12-18T20:56:49.544Z
|
10,870,968 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1074/JBC.271.24.14567",
"MAG": "1968241038",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Utilizing a method called “differential display of mRNAs by means of polymerase chain reaction”, the cDNA fragment of a thyroid hormone-responsive gene ZAKI-4 was cloned from cultured human skin fibroblasts. Northern blot analysis revealed that there were two ZAKI-4 mRNA species (3.4 and 1.4 kilobases (kb)), and they were up-regulated by a physiological concentration of triiodothyronine (T3). This T3 effect was abolished by the treatment with cycloheximide, indicating the possibility that gene ZAKI-4 is regulated by T3 in an indirect fashion, through an intermediate product of T3, rather directly by T3 itself. No effect of T3 on ZAKI-4 mRNA stability suggested that T3 induces the mRNA at the transcriptional level. Rapid amplification of cDNA ends confirmed the presence of two mRNA species. ZAKI-4 mRNA was detected in heart, brain, liver, and skeletal muscle but not in placenta, lung, kidney and pancreas. In skin fibroblasts and skeletal muscle, 3.4-kb mRNA was the major species, whereas 1.4-kb mRNA was dominant in heart, brain, and liver. The sequence analysis suggested that the two mRNA species arise from alternative polyadenylation and code a single protein of 192 amino acids. No homologous protein sequence was found in a data base. Elucidation of the function of ZAKI-4 gene product will provide new insights into an important role of T3 in various organs.
|
2022-12-26T16:58:07.255Z
|
236,411,452 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.24115/S2446-622020217EXTRA-B950P.462-467",
"MAG": "3165930181",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The purpose of the article is to study the legal nature and essence of the constitutional mechanism for the protection of citizens' rights in modern Russia. The leading method of studying the problem is the deductive method, which allows studying the legal nature and features of the implementation of the constitutional mechanism for protecting the rights of citizens in Russia. The article uses the inductive method, the method of systematic scientific analysis, and comparative legal and historical methods. The article concludes that the constitutional and legal status (as a legally fixed position of a person in their relations with the state and society) is part of the social status of an individual in society. The latter, in turn, is determined not only by legal norms but also by other regulators (political, moral, religious, etc.), mediating the diverse connections of a person with society and the state.
|
2022-12-02T11:45:55.786Z
|
16,339,093 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/ICASSP.2002.5743689",
"MAG": "2169373368",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In this paper we propose an enhancement of the Jacobian adaptation by estimating automatically a noise over estimation factor which yields to a closer approximation of Parallel model combination (PMC) than the traditional Jacobian adaptation. Noise over estimation factors are estimated at run-time for a set of clustered Gaussians obtained on the training set. Experiments conducted on a French natural number database show that similar performance as PMC can be obtained at the expense of a slight increase in computational complexity as compared to Jacobian adaptation.
|
2022-12-30T00:29:02.160Z
|
143,224,188 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5902/2176148512010",
"MAG": "1927919749",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Este texto enfoca a presenca francesa na literatura e na cultura brasileiras, do romantismo com seu indianismo a la Chateaubriand ate o modernismo de oswald de Andrade e tarsila do Amaral. Como todo contato entre povos, o dialogo entre o brasil e a Franca tem seus tempos fracos e seus tempos fortes; nestes, incluem-se duas importantes “missoes francesas”, a de 1816 e a de 1934. Tambem se busca refletir sobre o papel do ensino do frances no brasil ou no eixo das relacoes coloniais, a partir do pensamento de autores como Derrida e Glissant.
|
2022-01-24T21:18:52.630Z
|
225,628,009 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1215/00382876-8601470",
"MAG": "3033542592",
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
In September 2017, feminist assemblies began meeting on the eighth day of each month in multiple cities and towns across Spain to prepare for the feminist strike in the country. That same fall, the trial is held for the “wolf pack,” the gang rape that occurred during the festival of San Fermín in 2016: once again, the woman who was raped is put on trial, and not the rapists. With the slogans, “I believe you” and “Listen, sister, here is your pack,” the call goes viral, filling streets, plazas, and social media. This viral call is repeated in April when the sentence in announced that only condemns the members of the group for “abuse” and not for rape, and with even one vote from a judge who dared to say that there was enjoyment on all sides. The streets are dyed a feminist purple: a capillary feminism that reacts as a single body against each piece of news of sexist violence. In that atmosphere, and following a massive feminist strike on March 8, the denunciation of sexual abuse presented by several seasonal strawberry pickers in Huelva leaps into the media. Some collectives call for a march, expecting it to go viral again. However, the response it not at all the same either in number or in intensity. What happened? Debates catch fire. There are accusations: the feminism organized around March 8 and that was expressed in the protests against the wolf pack is racist. The answer is more complex, but there is no doubt that the feminist defiance of the seasonal strawberry workers challenges organized feminism and the unions in an unprecedented way. It speaks of the capillary quality of feminist sensibility, but also of its limits and paradoxes.
|
2022-02-08T00:07:25.840Z
|
97,274,904 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.1080/00958972.2012.689827",
"MAG": "2074806292",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A 1-D copper(II) coordination polymer and two mononuclear copper(II) complexes of 4-formylbenzoate, [Cu(L)2(H2O)2] n (1), [Cu(L)2(D,L-cam)] (2), and [Cu(L)(bpy)2] · (ClO4)(H2O) (3) (HL = 4-formylbenzoic acid, D,L-cam = D,L-camphoric diamine, bpy = 2,2′-bipyridine), have been obtained from cleavage of C=N double bonds of a bis-Schiff-base compound. 4-Formylbenzoate exhibits bidentate chelating and bidentate μ 2-bridging modes by terminal carboxylic and aldehydic groups in 1-D coordination polymer 1. In contrast, it shows bidentate chelating in 2 and monodentate and bidentate bonding in 3 by its terminal carboxylic group where the aldehydic group does not coordinate. Offset π–π stacking interactions and two types of 8-membered hydrogen-bonding rings are found between neighboring molecules of the copper(II) complexes.
|
2022-09-28T00:27:23.275Z
|
251,870,919 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3390/coatings12091241",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.mdpi.com/2079-6412/12/9/1241/pdf?version=1661423422"
}
|
In this research, the influences of the addition of PVP to PVDF-HFP polymers and the preparation of thin films using a solvent casting method were studied. The PVDF-HFP and polymer blend PVDF-HFP/PVP thin films with a nanostructured surface were investigated using scanning electron microscopy, differential scanning calorimetry, nanoindentation, and dielectric spectroscopy. The results showed that the PVP formed a dispersed phase (the poorer conductive islands) in the PVDF-HFP polymer matrix, which reduced its mechanical properties. The crystallinity of PVDF-HFP polymer decreased with the addition of PVP by 7.4%, but the PVP induced the formation of the polar β-phase of PVDF-HFP. Therefore, an improved dielectric response is expected, but it was not significantly improved even though the polar β-phase was detected. The contrasting effect was attributed to less conductive PVP islands on the surface of the PVDF-HFP/PVP polymer blend, which decreased its conductivity.
|
2022-10-02T15:55:18.523Z
|
253,070,814 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.25130/jtuh.29.3.1.2022.20",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBY",
"status": "HYBRID",
"url": "https://jtuh.org/index.php/jtuh/article/download/286/417"
}
|
استهدفت الدراسة الى الكشف عن متطلبات التعليم المدمج في عملية تدريس مادة القرآن الكريم والتربية الاسلامية للمرحلة المتوسطة الواجب توافرها في محاور ( الموقف التعليمي او البيئة التعليمية, المنهج ,المدرس , المتعلم ) , فضلاً عن اختلافات استجابات عينة البحث . ولتحقيق اهداف البحث تم الاعتماد على المنهج الوصفي , تكونت عينة الدراسة من (110) مدرساً ومدرسة , من مدرسي مادة القرآن الكريم والتربية الاسلامية في الانبار وكانت الاستبانة اداة لجمع المعلومات., وقد اسفرت نتائج البحث عن :
ان تقييم المدرسين في المدارس المتوسطة للتعليم المدمج من حيث متطلباته الواجب توافرها في كل من المحاور (البيئة التعليمية والمنهج والمدرس والمتعلم) على درجة كبيرة جدا.
اما من حيث درجة توفر متطلبات التعليم المدمج فحصلت كل من المحاور (البيئة التعليمية) على درجة ضعيفة واما المحاور ( المنهج والمدرس والمتعلم) على درجة متوسطة.
وأوصى البحث ضرورة الاستفادة من نتائج البحث وخصوصاً في ما يتعلق بمحوري المدرس والبيئة
|
2022-10-28T00:42:53.311Z
|
127,086,172 |
{
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"ACL": null,
"ArXiv": null,
"DOI": "10.1520/STP28344S",
"MAG": "346486948",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
An investigation of ten rock types in unconfined compression has led to four distinct types of stress versus acoustic emission response curves, that is, signatures. These are the originally proposed Mogi type, and three variations of this generalized behavior, that is, unstable, dense, and dense unstable types. They have been correlated to conceptual ideas on brittle rock behavior. Frequency analysis on all rock types at each stage of the various stress ranges has also been performed. Trends in peak frequency shifting are presented with implications as to the use of this information. (Authors)
|
2022-12-12T01:56:42.408Z
|
234,149,170 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1089/aut.2020.0046",
"MAG": "3118997953",
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
Background: Strikingly little research has considered how autistic adults experience pregnancy and parenthood, two key transition periods in adult development with potentially far-reaching implicat...
|
2022-09-23T16:17:08.385Z
|
19,179,980 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1037/0893-164X.17.2.159",
"MAG": "1983047658",
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},
"license": null,
"status": null,
"url": null
}
|
The relationship between spirituality and HIV risk behavior in a sample of 34 inner-city cocaine-using methadone-maintained patients was examined. Spirituality was operationally defined in terms of "life meaningfulness" and included the Santa Clara Strength of Religious Faith (T. G. Plante & M. T. Boccaccini, 1997b) and the World Assumptions Scale (R. Janoff-Bulman, 1989; assessing benevolence, meaningfulness, and worthiness of the self). Hierarchical multiple regression analyses of self-reported drug- and sex-related risk behavior were conducted with sex and race entered as control variables. The full models accounted for 23% and 42% of the variance in drug- and sex-related risk behavior, respectively. Strength of spiritual/religious faith (B = .37) and belief in a benevolent (beta = .50) and meaningful (beta = .46) world were independent predictors of sex-related, but not drug-related, HIV preventive behavior.
|
2022-12-16T07:06:32.568Z
|
30,897,902 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/APS.2012.6348076",
"MAG": "2101274990",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A design for a switchable metamaterial is presented that allows for digital control over its bulk properties, from near-zero-index to near-free-space at the targeted operational frequency. A distributed shift register is formed over the slab of metamaterial for individual control of varactor diodes within each unit cell, which tune the resonant frequencies of modified split-ring resonators within selected regions of a hexagonal array. The metamaterial was designed using off-the-shelf components for integration into a cylindrical transformation electromagnetics metamaterial beam-scanning lens for dynamic single-feed antenna beamforming.
|
2022-12-17T13:51:04.551Z
|
225,804,460 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.22111/IJBDS.2020.5441",
"MAG": "3044215681",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Given the increasing importance of achieving low and stable inflation rate during the last decades, adopting the most suitable practices to implement monetary policies has always been of concern by monetary authorities of different countries. Inflation targeting (IT) regime is the most recent strategy to guide monetary policies that have been introduced following the occurrence of exchange rate targeting and monetary targeting problems. In this respect, in the present research, the performance of a number of IT countries versus that of the non-targeting ones was first investigated employing the difference in difference (DID) method. Then, considering monetary and oil shocks, IT performance in production gap in the economy of Iran was practically examined using smooth transition autoregressive regression (STAR) model. The Results indicated that implementation of IT policy was successful in applying the four main and most influential indicators in the production of treatment countries. In addition, it was revealed that variables such as IT, oil shock, and facility and exchange rates had a statistically negative effect on production shock in the economy of Iran. However, the monetary shock was found to have a statistically positive impact on production shock. Therefore, according to the findings regarding the successful performance of targeting countries, policymakers are recommended to implement IT policy during a long-term interval in order to stabilize it and also provide its prerequisites in the economy of Iran. JEL classification: E31, E58, E52.
|
2022-01-27T04:14:13.259Z
|
234,090,757 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.46661/REVINTPENSAMPOLIT.5603",
"MAG": "3131667369",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Nunca en la historia de nuestra democracia habíamos asistido a una limitación y/o suspensión de derechos tan grave y duradera en el tiempo como la vivida durante la pandemia. Por ello, resulta necesario analizar el sistema de fuentes del derecho de excepción contrastando sus características con las del sistema de fuentes ordinario. Para cumplir este objetivo, tendremos que comparar a su vez las características del estado de alarma con el de excepción, y ambos, con las medidas extraordinarias que permite la legislación ordinria. Con este fin emplearemos siete criterios, lo que nos permitirá, además de clarificar ambos sistemas de fuentes, poner de manifiesto cómo el estado de alarma ha provocado una brecha en la seguridad de nuestro ordenamiento jurídico que debe ser resuelta cuanto antes.
|
2022-02-07T21:41:50.456Z
|
155,764,114 |
{
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"ArXiv": null,
"DOI": "10.31499/2306-5532.1.2012.18677",
"MAG": "2256472734",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Статтю присвячено проблемам розвитку освітніх систем США й України як в національному так і в глобальному демократичному просторі. Наголошено на ролі гуманітарн ої складов ої освіт и ; підкреслено важливість надання якісних освітніх посліг у період переходу від елітарності до егалітарності. Статья посвящена проблемам развития образовательных систем США и Украины как в национальном, так и глобальном демократическом пространстве. Подчеркнута роль гуманитарной составляющей образования; акцентирована важность предоставления качественных образовательных услуг в период перехода от элитарности к эгалитарности. The article is devoted to the problems of the development of educational systems of the USA and Ukraine at the national and global scale. The role of humanitarian component in education has been stressed; the importance of quality education services in the time of switching from eliteness to egalitarianism has been drawn attention to.
|
2022-02-09T01:08:22.744Z
|
95,871,595 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1051/JPHYSCOL:1986520",
"MAG": "2018791097",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
R6sum6 - Un systsme pour effectuer des mesures cinetiques aux rayons X sur des muscles est decrit, de mzme que le logiciel d'acquisition de donnkes et d'analyse des rksultats. Plusieurs exemples d'application sont donnks. Abstract - A system for making time-resolved X-ray measurements from muscle is described in this paper along with real-time software for data acquisition and software for further analysis. Several examples illustrating the use of the system are also given. The technique of time resolved X-ray diffraction is a powerful tool for studying dynamic processes in structural biology where ordered structures are involved, and has proven of particular value in the study of vertebrate skeletal muscle. The principal ideas behind the technique are relatively simple - one needs to record the X-ray pattern from a contracting muscle in a stroboscopic manner, the data being recorded in such a way that it is possible to distinguish patterns from different phases of muscle contraction. It is possible to calculate the extent of changes in the molecular structure as a function of time from the changes in the X-ray pattern provided one has knowledge of the starting structure 191; partial information is available for vertebrate muscle from a number of techniques, including electron microscopy, biochemistry and conventional X-ray diffraction studies. The basic contractile muscle unit, the sarcomere, shown in Fig 1, consists of two types of inter-digitating protein filaments 181. The 'thick' filaments, consisting mainly of myosin are about 1.6 pm in length and have an array of 'projections' along most of its length arranged in a helical fashion. The thin filaments are about 1 pm in length and consist mainly of actin with smaller quantities of the regulatory proteins tropomyosin and troponin. The thin filaments are attached to the Z-lines, the distance between two Z-lines being approximately 2.3 pm at normal body length. It is believed that during contraction the projections on the thick filament form cross-bridges with the thin filament and go through a 'conformational' change which produces a relative sliding movement between the two filaments. The polarity of the filaments is reversed half-way along the sarcomere so that opposing forces are generated in the two halves. A large number of sarcomeres generate force in series and in parallel which is transmitted to the skeleton through the tendons to allow external work to be performed.
|
2022-02-10T15:01:59.102Z
|
4,716,448 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1371/journal.pone.0192906",
"MAG": "2793364025",
"PubMedCentral": "5831035"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0192906&type=printable"
}
|
Stimulus sets are valuable tools that can facilitate the work of researchers designing experiments. Images of faces, and line drawings of objects have been developed and validated, however, pictures of animals, that do not contain backgrounds, have not been made available. Here we present image agreement and quality ratings for a set of 640 color images of animals on a transparent background, across 60 different basic categories (e.g. cat, dog, frog, bird), some with few, and others with many exemplars. These images were normed on 302 participants. Image agreement was measured both with respect to the proportion of participants that provided the same name as well as the H-statistic for each image. Image quality was measured both overall, and with respect to the accuracy of participants’ naming of the basic category. Word frequency of each basic and superordinate category based on the English Lexicon Project (Balota, et al., 2007) and the HAL database (Kucera & Francis, 1976) are provided as are Age of Acquisition (Kuperman, Stadthagen-Gonzalez, & Brysbaert, 2012) data.
|
2022-09-13T00:40:01.349Z
|
28,112,056 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3928/01484834-20151110-10",
"MAG": "2394936845",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
BACKGROUND
Interprofessional education and global health are priorities in health professions education. Health organizations such as the Institute of Medicine and the World Health Organization recommend that education of health care providers be interdisciplinary and use technology.
METHOD
A webinar took place between adult gerontology nurse practitioner (AGNP) students in the United States and the providers of a clinic in the Dominican Republic. The providers from the Dominican Republic presented a case typical of their practices but one with which AGNP students were not familiar. Similarly, the AGNP students presented a case representing new information for the Dominican providers.
RESULTS
All participants responded positively to the webinar, primarily because of the technological and case-based approach to learning; they benefitted from disease review and interprofessional collaboration.
CONCLUSION
A webinar format across clinical settings and countries is a novel interprofessional way to disseminate information in a mutually beneficial way.
|
2022-10-18T17:20:24.584Z
|
253,551,101 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/13880209.2022.2142614",
"MAG": null,
"PubMedCentral": "9673777"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://doi.org/10.1080/13880209.2022.2142614"
}
|
Abstract Context Isoorientin has many biological activities, including antioxidant, anti-inflammatory, antitumor. However, the effect of isoorientin on postmenopausal osteoporosis remains unclear. Objective To evaluate the effect of isoorientin on postmenopausal osteoporosis. Materials and methods Sprague-Dawley rats were divided into five groups (n = 5): sham, model, 17-β-oestradiol (E2, 10 μg/kg/day), low-dose isoorientin (L-Iso, 50 mg/kg), and high-dose isoorientin (H-Iso, 100 mg/kg). The rats were ovariectomized, treated by gavage daily for 12 weeks, and serum and femur samples were collected. Bone mineral density, bone metabolism, and oxidative stress were assessed. H&E staining, immunohistochemistry, and western blotting were employed. Results Isoorientin improved the bone mineral density of the lumbar vertebrae (2.01 ± 0.05 g/cm3 in H-Iso group vs. 1.74 ± 0.07 g/cm3 in model group) and femur (1.46 ± 0.06 g/cm3 vs. 1.19 ± 0.03 g/cm3), increased the trabecular bone number (1.97 ± 0.03 vs. 1.18 ± 0.13) and thickness (0.27 ± 0.02 vs. 0.16 ± 0.03 mm). Isoorientin decreased the separation degree of trabecular bone, ameliorated bone histomorphology changes, and significantly improved the mechanical properties. Isoorientin diminished MDA (by 60%) and increased SOD (by 49.2%), and GSH-Px (by 159%) activity. Furthermore, osteoprotegerin (OPG), nuclear factor erythroid 2-like 2 (Nrf2), haem oxygenase (HO-1), NAD(P)H quinone dehydrogenase 1(NQO1), and oestrogen receptor 1(ESR1) protein expression increased, while receptor activator of nuclear factor-κB ligand (RANKL) protein expression decreased after treatment. Conclusions Isoorientin ameliorates osteoporosis via upregulating OPG and Nrf2/ARE signalling, suggesting isoorientin maybe a potential therapeutic drug for PMOP.
|
2022-12-02T11:18:22Z
|
12,162,679 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3233/JCS-1996-4104",
"MAG": "1604692831",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A calculus of channel security properties is presented which allows the analysis and comparison of protocols for establishing secure channels in a distributed open system at a high level of abstraction. A channel is characterized by its direction, its time of availability and its security properties. Cryptographic primitives as well as trust relations are interpreted as transformations for channel security properties, and a cryptographic protocol can be viewed as a sequence of such transformations. A protocol thus allows to transform a set of secure channels established during an initial setup phase, together with a set of insecure channels available during operation of the system, into the set of secure channels specified by the security requirements. The necessary and sufficient requirements for establishing a secure channel between two entities A and B are characterized in terms of secure channels to be made available during the initial setup phase and in terms of the minimal trust A and B must have into other entities or into trusted third parties.
|
2022-12-09T12:16:44.528Z
|
206,913,865 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1136/bmj.i945",
"MAG": "2296647505",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
#### What you need to know
Bariatric surgery is the most effective treatment for sustained weight loss in people with complex obesity,1 2 and reports from large UK and international registries highlight its overall safety.3 4 The overall mortality of 0.07% and composite complication rate of less than 4% for gastric bypass are similar to those for laparoscopic cholecystectomy.4 After surgery, short hospital stays are the norm (median one day for gastric band and two days for a sleeve gastrectomy or gastric bypass).2 General practitioners thus need to recognise early, as well as late, postoperative complications, monitor long term nutrition, and provide support. General practitioners may also need to assess patients who have had bariatric surgery abroad (sometimes with non-standard procedures), without any follow-up planned. Useful resources for patients include BOSPA (http://www.bospauk.org) and WLSinfo (http://www.wlsinfo.org.uk).
Box 1 describes the three most common procedures performed in the United Kingdom. More than 95% are done laparoscopically.3 5
#### Box 1: Most common bariatric surgery procedures in UK (fig 1⇓)
##### Laparoscopic adjustable gastric banding
An adjustable band is placed around the top of the stomach, forming a small gastric pouch above it. The band is adjusted by injecting saline into a port positioned under the skin to achieve the sensation of fullness after a small amount of food.
##### Roux-en-Y gastric bypass
The most common operation for weight loss in the UK NHS (60%), involving creation of a small gastric pouch by stapling. A classical Roux-en-Y reconstruction is then fashioned with …
|
2022-12-18T09:22:49.326Z
|
185,362,729 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3917/PLD.111.0035",
"MAG": "2565489397",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Cherchant a tout prix a empecher l’acces des migrants a son territoire,
l’UE s’est engagee dans une cooperation avec des Etats tiers qualifies
pour l’occasion de « pays surs » pour qu’ils prennent en charge le
controle des migrations vers l’Europe. L’accord passe avec la Turquie le
18 mars 2016 s’inscrit dans ce processus d’externalisation. Malgre les
graves atteintes aux libertes fondamentales exercees par le regime turc,
l’UE continue de voir dans cet accord la solution a privilegier.
|
2022-02-08T11:31:44.858Z
|
133,080,376 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.19052/ED.3667",
"MAG": "2589005709",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
El deterioro del cauce del rio Magdalena ha afectado de modo negativo la pesca y el aprovechamiento de los suelos riverenos para establecer sitios de recreacion o cultivos de pancoger. Las actuales condiciones de vida de la poblacion riberena del municipio de Girardot se han afectado socioeconomica, ambiental y culturalmente. Como objetivo de la fase I del proyecto de investigacion, este articulo describe las necesidades basicas identificadas en cinco sectores poblacionales clasificados por actividades economicas. La investigacion se orienta a mensurar el deterioro de la ribera en mencion y a plantear alternativas que disminuyan la problematica de los grupos poblacionales. Esto a partir de informacion obtenida a traves de consulta directa con los pobladores de Girardot y sobre la base de insumos del subproyecto: Identificacion y caracterizacion de las dinamicas economicas del eje regional Girardot, Puerto Salgar y el estado de sistemas productivos y empresariales en los municipios de Girardot, Ambalema y Honda, el cual hace parte del macroproyecto Conociendo, explorando y aportando elementos para la transformacion social y productiva del rio Magdalena desde una vision integral, de la Universidad Piloto de Colombia.
|
2022-02-09T12:50:18.378Z
|
164,118,643 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2307/2500866",
"MAG": "2334359484",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
cated in some of them. What he defines as an immutable patriotic lineage spanning the centuries is really the continuation of a distinct discourse, one which derives its being, not from an essential, uniquely Czech origin, but from the late eighteenthcentury tenets of German idealism. More important than fitting a name and identity to a text written in an age when authorial identity was deemed irrelevant is the task of differentiating between various discourses, feudal and patriotic. Just as important is the need to perceive the different meanings derived from these discourses. But such an expectation runs counter to a pronounced monistic strain in Czech thought. As Eva Schmidt-Hartmann argues in an important article entitled "Forty Years of Historiography under Socialism in Czechoslovakia" (Bohemia 1988), the tenacious habit of ascribing a monolithic meaning to Czech history has led to a general state of stagnation in post-war Czech historiography. St'astny's conclusion typifies this monistic principle. The problem of meaning and hermeneutics is also central to the chronicle itself and the reader's response to it. The prologue to the chronicle distinguishes between the "empty discourses" (feci prdzdne) of the Latin sources and the "complete meaning" (smysl cely) that_the author claims to derive from the historical and fictional material at his disposal. St'astny interprets this distinction in straightforward terms as an expression of patriotic feeling, failing to see that it is a rhetorical sleight of hand intended to validate the author's ideological agenda. In his essay "O smyslu literarnich dejin ceskych" (the meaning of Czech literary history), published in 1937, the great Czech critic F. X. Salda warned against attributing anachronistic ideas derived from Herder and Fichte to the medieval author of The Dalimil Chronicle. Although St'astny's work provides a valuable, well researched enquiry into the origins and reception of the first vernacular history of the Czech people, its conclusion exemplifies Salda's thoughtful warning. In so doing, it reveals more about a particular patriotic discourse formed in the Enlightenment and its recuperation in the new Czech democracy than it does about the mystery named "Dalimil."
|
2022-08-03T18:22:13.303Z
|
76,003,341 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.9790/0853-0841822",
"MAG": "2322185067",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://doi.org/10.9790/0853-0841822"
}
|
Violence against women could be physical, mental or sexual. It reflects inequities between men and women and compromises health, dignity, security & autonomy of the victims. The present study was carried out at the Urban Health Centre & included all married women in the reproductive age, to study various factors associated with violence, and the decision making power of the women. Objectives: 1. To identify socio-cultural and demographic factors related to domestic violence. 2. To assess health status of these women. 3. To assess decision making power of women and its relationship with domestic violence. Methodology: A cross-sectional, descriptive, epidemiological study was carried out at Urban Health Centre, Govandi , field practice area affiliated to the Department of Preventive & Social Medicine, Topiwala National Medical College, Mumbai, during the period from 1 st February 2008 - 31 st March 2008. Study population included married women who experienced domestic violence, in the age group 15-45 years, attending general OPD (n = 105). Women were enquired about the type of violence faced by them , their perpetrators, the perceived risk factors and their decision making power in the family. Data was analyzed using SPSS 11.5. Results : Women who experienced violence were included in the study (n=105). Most of them (82.86%) were Muslims, illiterate(53.34%) and were in the age group 26 - 35 years(57.14%). The violence faced by them was mostly Verbal(71.42%) and Physical violence (48.57%), with perpetrators being mostly their husbands' and Mother- in - law. These women did not have any power in decision making in the family.
|
2022-08-17T07:22:59.167Z
|
253,296,880 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.24036/jtip.v15i1.586",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBYSA",
"status": "GOLD",
"url": "http://tip.ppj.unp.ac.id/index.php/tip/article/download/586/224"
}
|
Technological developments are increasingly rapid so that it is no longer something that is not known to the public. The use of computers has developed, especially as an alternative in the assessment of school accreditation administration, including in the management of alumni data known as Tracer study. Tracer Study is an approach that allows institutions or higher education to obtain information about deficiencies that may occur in the educational process and learning process. Data management for alumni of Senior High School 1 Bukittinggi is dominated using paper media and data management is still difficult. By utilizing web technology, information can be accessed without any limitations of space and time. This is intended to facilitate the management of the alumni data list, which was initially still carried out using very commonly used applications, such as Microsoft being the Tracer Study system for Senior High School 1 Bukittinggi which will help manage alumni data. This system is designed using the Python programming language with the Django framework that utilizes the MVT architecture and is combined with the DevOps method, resulting in a system that can be used by schools to manage alumni data. This system provides several services, namely alumni search, filling out questionnaires, verifying reports, and exporting reports.
|
2022-11-05T15:51:24.833Z
|
119,097,482 |
{
"externalids": {
"ACL": null,
"ArXiv": "1210.7321",
"DOI": "10.1142/S0217751X1350108X",
"MAG": "2032476066",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
For the newly proposed coupled (but equivalent) Lagrangians for the supersymmetric (SUSY) system of a one (0+1)-dimensional spinning relativistic particle, we derive the Noether conserved charges corresponding to its (super)gauge, Becchi–Rouet–Stora–Tyutin (BRST), anti-BRST and ghost-scale symmetry transformations. We deduce the underlying algebra amongst the continuous symmetry operators and corresponding conserved charges. We point out a novel observation that emerges, for this specific SUSY system, when we discuss it within the framework of BRST formalism. In particular, the requirement of the physicality criteria with the (anti-)BRST charges leads to a completely new observation because, as it turns out, one of the primary constraints does not annihilate the physical state of the theory. We have never come across this kind of result in the realm of BRST approach to usual gauge theories. We provide the physical and theoretical reasons behind the above observation.
|
2022-12-09T11:45:34.588Z
|
26,307,651 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.7717/peerj.1626",
"MAG": "1797982246",
"PubMedCentral": "4741062"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://doi.org/10.7717/peerj.1626"
}
|
We report a new ichthyopterygian assemblage from Lower Triassic horizons of the Prida Formation at Fossil Hill in central Nevada. Although fragmentary, the specimens collected so far document a diverse fauna. One partial jaw exhibits isodont dentition with blunt tipped, mesiodistally compressed crowns and striated enamel. These features are shared with the Early Triassic genus Utatsusaurus known from coeval deposits in Japan and British Columbia. An additional specimen exhibits a different dentition characterized by relatively small, rounded posterior teeth resembling other Early Triassic ichthyopterygians, particularly Grippia. This Nevada assemblage marks a southward latitudinal extension for Early Triassic ichthyopterygians along the eastern margin of Panthalassa and indicates repeated trans-hemispheric dispersal events in Early Triassic ichthyopterygians.
|
2022-12-15T00:06:37.669Z
|
23,653,994 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1097/00001888-200112000-00010",
"MAG": "2088591386",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://journals.lww.com/academicmedicine/Fulltext/2001/12000/An_Admission_Model_for_Medical_Schools.10.aspx"
}
|
Complex societal issues affect medical education and thus require new approaches from medical school admission officers. One of these issues—the recognition that the attributes of good doctors include character qualities such as compassion, altruism, respect, and integrity—has resulted in the recent focus on the greater use of qualitative variables, such as those just stated, for selected candidates. In addition, more emphasis is now being placed on teaching and licensure testing of the attributes of the profession during the four-year curriculum. The second and more contentious issue concerns the system used to admit white and minority applicants. Emphasizing character qualities of physicians in the admission criteria and selection process involves a paradigm shift that could serve to resolve both issues. To make this or any paradigm shift in admission policy, medical schools must think about all the elements of admission and their interrelationships. A model of medical school admission is proposed that can provide understanding of the admission system and serve as a heuristic guide. This model consists of (1) the applicant pool; (2) criteria for selection; (3) the admission committee; (4) selection processes and policies; and (5) outcomes. Each of these dimensions and the interrelationships among the dimensions are described. Finally, a hypothetical example is provided in which the model is used to help a medical school change its admission process to accommodate a new emphasis in the school's mission.
|
2022-12-17T07:45:31.348Z
|
254,611,532 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.21202/2782-2923.2022.4.745-761",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBYNC",
"status": "GOLD",
"url": "https://www.rusjel.ru/jour/article/download/2314/2198"
}
|
Objective: to analyze the transforming socio-economic relations of the new “digital normality”, to which end the task is solved of bringing into line the terminology used in business turnover between various participants in the digital assets market, in the practical financial activities of economic entities arising in a specific territory, in a certain legal field, and contained in the recommendatory technical documentation (standards).Methods: the article uses systematic and analytical approaches, logical and comparative methods.Results: despite the active use of distributed ledger technologies, theory and practice are currently characterized by a large number of legal and business definitions describing the organization of business processes in this area. Based on the analysis of scientific literature, the meaning of various terms of the digital economy was studied. In the course of studying technical terminology, such concepts as a distributed ledger, network nodes, blockchain, etc. were defined. The analysis of financial and economic terms is based on fintech definitions, such as digital asset, cryptocurrency, digital currency, digital financial asset, token, etc. The terms of the digital economy are considered from the perspective of so-called tokenomics, including such as token ecosystem, DLT user, DLT platform, decentralized application, etc.Scientific novelty: the terminology obtained was structured as a theoretical basis with a specification for the digital asset market and use in financial market reform.Practical significance: this review has been prepared: 1) to systematically familiarize the professional community with existing trends; 2) to harmonize socio-economic relations by developing common local recommendations (standards); 3) to develop the market for digital assets produced using distributed ledger technologies through understanding basic concepts.
|
2022-12-16T20:59:31.947Z
|
225,443,503 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1158/1538-7445.am2020-ct023",
"MAG": "3082829449",
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
Introduction Minimal residual disease (MRD) detection in solid tumors describes isolation of circulating tumor DNA (ctDNA) molecules in plasma following definitive treatment of a cancer. Detection of MRD following surgical tumor excision categorizes patients as high risk for disease recurrence. Establishing an MRD approach to treating early-stage NSCLC will facilitate escalation of standard of care (SoC) treatment only in patients destined to relapse from their cancer and overcome challenges associated with conventional adjuvant drug-trial design. Here, we present data from the lung TRACERx study where patients with early-stage NSCLC underwent phylogenetic ctDNA profiling following resection. Methods Patient specific anchored-multiplex PCR (AMP) enrichment panels were generated for 78 lung TRACERx patients who underwent surgery for stage I-III NSCLC; 608 plasma samples were analyzed. Extensive patient-specific cfDNA enrichment panels targeted a median of 196 (range 72 to 482) clonal and subclonal variants detected in primary tumor tissue by multi-region exome sequencing. A novel MRD-caller controlled and estimated background sequencing error to maximize ctDNA detection at low mutant allele frequencies (MAFs). Analytical validation experiments benchmarked assay performance. Results Analytical validation of a 50-variant AMP-MRD assay demonstrated a sensitivity of 89% for mutant DNA at a MAF of 0.008% (with 25ng of DNA input into the assay), specificity was 100% experimentally and 99.9% (95% CI: 99.67 to 99.99%) modelled in-silico. 45 patients suffered relapse of their primary NSCLC; ctDNA was detected at or before clinical relapse in 37 of 45 patients. In these 37 patients the median ctDNA lead-time (time from ctDNA detection to clinical relapse) was 151 days (range 0 to 984 days) and the median time to relapse from surgery was 413 days (range 41 to 1242 days). In 10 of 10 patients who developed second primary cancers during follow-up no ctDNA was detected, reflecting specificity of the MRD assay toward the primary tumor. In 23 patients who remained relapse-free during a median of 1184 days of study follow-up, ctDNA was detected in 1 of 199 time-points analyzed. Analysis of SoC adjuvant surveillance imaging (CT, PET-CT or MRI, 220 encounters) revealed examples of MRD positive patients where SoC radiological surveillance was negative for impending relapse. Through application of large cfDNA enrichment panels targeting up to 483 variants per patient we observed dynamic changes in clonal composition and copy-number status prior to NSCLC relapse, categorized relapse as monoclonal or polyclonal and identified distinct subclonal dynamics during systemic intervention for disease recurrence. Conclusions ctDNA is an adjuvant biomarker capable of both detecting MRD following surgery and defining the clonality of relapsing disease. These data pave the way for clinical trials predicated on escalation of adjuvant standard of care in NSCLC patients who exhibit MRD positive status following surgery. Citation Format: Chris Abbosh, Alexander Frankell, Aaron Garnett, Thomas Harrison, Morgan Weichert, Abel Licon, Selvaraju Veeriah, Bob Daber, Mike Moreau, Adrian Chesh, Kevin Litchfield, Emilia Lim, Daniel Cooke, Clare Puttick, Maise Al Bakir, Fabio Gomes, Akshay Patel, Lizi Manzano, Ariana Huebner, Nicolas Carey, Joan Riley, Paula Roberts, Todd Druley, Jacqui A. Shaw, Nicholas McGranahan, Mariam Jamal-Hanjani, Nicolai Birkbak, Josh Stahl, Charles Swanton, Lung TRACERx consortium. Phylogenetic tracking and minimal residual disease detection using ctDNA in early-stage NSCLC: A lung TRACERx study [abstract]. In: Proceedings of the Annual Meeting of the American Association for Cancer Research 2020; 2020 Apr 27-28 and Jun 22-24. Philadelphia (PA): AACR; Cancer Res 2020;80(16 Suppl):Abstract nr CT023.
|
2022-12-23T19:55:23.588Z
|
134,051,380 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.24832/kapata.v13i1.388",
"MAG": "2737721151",
"PubMedCentral": null
},
"license": "CCBYNCSA",
"status": "GOLD",
"url": "http://kapata-arkeologi.kemdikbud.go.id/index.php/kapata/article/download/388/298"
}
|
Spice Route has become one of the main issues in the cultural historical studies of Indonesia recently. The discussion is still attached to effort to understand the existence of spice route as the part of the extensive trade system that have been initiated by the history of contact and interaction with the traveler from Western Asia; China; and the European explorers. There were almost no discussion that tried to explore the nature of the spice route prior to the contact with the Mainland Asia and the European. Including in the Maluku Archipelago. This paper discuss the formation process of the spice trade system in the prehistoric period and early historic period in Maluku from the archaeological perspective. The approach that has been adopted in this research is bibliographical studies. This paper found that the trade system and exchange in Maluku has been initiated since the prehistoric period as has been highlighted by the arcaheological studies in the region. Jalur rempah kembali menjadi salah satu isu yang mengemuka dalam diskusi sejarah budaya Nusantara setahun terakhir. Dimana wacana yang mengemuka umumnya masih mengamati keberadaan jalur rempah sebagai jejaring yang dibentuk oleh sejarah kontak dan interaksi dengan para penjelajah dari Asia Barat; Tiongkok dan terutama para pendatang Eropa. Hampir tak ada diskusi yang mencoba mengamati kemungkinan tumbuh kembang jalur niaga ini di era yang jauh lebih awal. Termasuk di Kepulauan Maluku. Makalah ini mencoba mengamati proses pembentukan jaringan niaga dan perdagangan rempah serta aneka komoditi eksotik di masa prasejarah dan awal sejarah di Kepulauan Maluku dari sudut pandang studi arkeologi. Pendekatan yang digunakan adalah kajian pustaka. Hasil kajian menemukan bahwa jaringan niaga dan pertukaran di Maluku telah dibentuk semenjak masa prasejarah sebagaimana ditunjukkan oleh ragam hasil penelitian arkeologi.
|
2022-05-10T00:39:09.160Z
|
244,222,930 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5380/AVS.V26I3.80459",
"MAG": "3203496294",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Chelonians have, historically, played an important role as a natural resource for human food in the Amazon region, among them the Kinosternon scorpioides species, the mucua. This is a semi-aquatic freshwater chelonian that has an omnivorous feeding habit. Due to the lack of research on the feeding of this species in captivity, the present study aimed to evaluate the acceptance and preference of fruits by K. scorpioides and to describe their feeding behavior in captivity. The study was conducted between January and June 2017, at the Scientific Breeding Ground of the Bio-Fauna Project / ISARH-UFRA. 36 mucuas were used, 18 in the fattening phase and 18 in the brooding phase, with an average initial weight of 438g (± 16.22g) and 84g (± 16.11g), respectively. The animals were housed in polyethylene boxes with 60% of the flooded area and 40% of the dry area, with three animals per box. In order to assess food preference, fresh fruits were used, classified as regional and non-regional Amazon. Each fruit was offered in a food/animal unit for 50 minutes. Monitoring of food preference was done with the help of video cameras. It was observed that the animals in the breeding phase were those that consumed a higher percentage of regional fruits (48.89%), when compared to the fattening phase that consumed 46.67% of the same fruits. Among the fruits offered, it was possible to observe a higher consumption of pupunha (Bactris gasipaes Kunth), melon (Cucumis melo L.) and mango (Mangifera indica L.) by both groups. The regional Amazonian fruits obtained great acceptance in which the pupunha was more prominent (88.89%) for the fattening phase, however the melon (63.19%) was the most consumed by the young.
|
2022-02-07T20:11:16.951Z
|
85,075,256 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2503/JJSHS.47.437",
"MAG": "2074431045",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
GA3 and ethephon were applied to satsuma mandarin (Citrus unshiu Marc.) fruit at a concentration of 100ppm 35 days before harvest. GA3 depressed the level of ABA in the flavedo during fruit maturation and senescence. On the contrary, ethephon raised the ABA level. Peroxidase activity in the flavedo decreased rapidly during fruit maturation and then leveled off towards senescence. This rapid decrease in enzyme activity was inhibited by GA3 application and accelerated by ethephon. Although there were 15 isozymes of peroxidase in the flavedo of immature fruit, some of the isozymes disappeared during fruit maturation and only 9 isozymes were finally found at harvest time. GA3 application decreased the reduction in number of peroxidase isozymes though it conversely increased the reduction in some isozymes. The activity of 2 isozymes was increased and other 2 isozymes disappeared by ethephon treatment. In general, very low activity and fewer isozymes of peroxidase were observed in the albedo as compared to those in the flavedo.
|
2022-08-19T22:56:40.313Z
|
214,199,375 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1177/1071181319631473",
"MAG": "2990990584",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://journals.sagepub.com/doi/pdf/10.1177/1071181319631473"
}
|
Fires and explosions often result from inadvertent actuation of kitchen range appliances. National Standards, such as ANSI Z21.1 and ANSI/UL858, provide guidance on the design of kitchen range controls to ensure the safe operation of these appliances. This work examines residential gas ranges as investigations of fire and explosion incidents often determine that there was no line leakage of gas and the leaked gas likely resulted from inadvertent contact with the range’s controls. A human factors investigation was conducted to determine under what conditions consumers (or their pets) could inadvertently open a closed gas range valve that was designed in a manner that met the requirements of applicable national standards. The investigation revealed that the range controls met the letter of the standard, but the safety intent of the standard was not met. Safety is sacrificed to afford usability. The control design is defective.
|
2022-08-19T19:43:49.288Z
|
25,286,380 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1046/j.1440-1746.1999.01930.x",
"MAG": "2086400185",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Background and Aims: Prostacyclin has been shown to play a role in hyperdynamic circulation in portal hypertension. Recently, a new subtype of cyclo‐oxygenase (COX), COX‐2, which acts as an inducible synthase in response to various stimuli. The aim of this study was to investigate whether COX‐2 contributes to portal hypertension and whether a COX‐2 blockade induces the same sort of gastric mucosal injury as a COX‐1 blockade.
|
2022-09-11T00:45:07.536Z
|
34,939,856 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/TENCON.2008.4766675",
"MAG": "2025349490",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Municipal corporation (MC) of a city is a local governing body which takes care of the functioning of the city. Among many other things one of the chief responsibilities of an MC includes addressing the complaints that the residents of the city might have. Maintenance of a large city requires that the MC be aware of any shortcomings either through surveillance (sensors/cameras) or by allowing the citizens to report them. The second option is usually preferred because there is a sense of belonging. A mechanism to accept complaints from citizens 24 times 7 would be the expectation from both the citizens and the MC. The Mumbai MC allows its citizens to place their complaints through several channels. The chief modes of complaint registration is (a) a visit to the ward office - where a person in charge listens to the complaint and asks for some personal details and put it across into an electronic form for other departments within the MC to handle the complaint, (b) through a contact center over a telephone - where the complaint is registered by an call center agent by typing the complaint into the system and more recently (c) through a web portal. In this paper, we propose a natural English enabled mobile interface which can be used to lodge complaints. The essential idea is to make use of the existing web portal infrastructure [6] and provide an easy, cheap and quick (complain as you see) mode of complaint registration around the clock. The proposed system enables and assists citizens to lodge compliant and seek redressal through their mobile phone in natural language.
|
2022-09-14T05:30:52.452Z
|
225,208,115 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/jfb.14488",
"MAG": "3048777776",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Here we report the first record of the Mayan cichlid, Mayaheros urophthalmus, occurring on an offshore island 70 km from the mainland, the most distant record from the mainland to date. Specimens were collected during several ichthyological surveys on the island of Guanaja, Honduras in November 2019. Mayan cichlids are euryhaline fishes that perform very well in fresh, brackish and marine waters. It has been hypothesized that the high tolerance to salinity and potential of using costal waterways has facilitated the colonization and expansion of M. urophthalmus.
|
2022-02-08T00:14:26.060Z
|
214,006,380 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1088/1742-6596/1382/1/012014",
"MAG": "2992084741",
"PubMedCentral": null
},
"license": null,
"status": "GOLD",
"url": "https://doi.org/10.1088/1742-6596/1382/1/012014"
}
|
Such fundamental scientific problem arises in much industrial application. The turbulent fluid dynamic characteristics were analyzed experimentally in a rotary-divergent flow. The laser Doppler anemometry was used for turbulent mass transfer diagnostics. The verification of numerical calculations by computational hydrodynamics has been carried out according to the results of experimental studies. Verification has shown that turbulent models describe the rotational-divergent flow well only until generation of flow gaps and formation of recirculation zones.
|
2022-12-10T10:21:07.260Z
|
26,629,005 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1128/JVI.01157-06",
"MAG": "1970362643",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
ABSTRACT Filoviruses, represented by the genera Ebolavirus and Marburgvirus, cause a lethal hemorrhagic fever in humans and in nonhuman primates. Although filovirus can replicate in various tissues or cell types in these animals, the molecular mechanisms of its broad tropism remain poorly understood. Here we show the involvement of members of the Tyro3 receptor tyrosine kinase family—Axl, Dtk, and Mer—in cell entry of filoviruses. Ectopic expression of these family members in lymphoid cells, which otherwise are highly resistant to filovirus infection, enhanced infection by pseudotype viruses carrying filovirus glycoproteins on their envelopes. This enhancement was reduced by antibodies to Tyro3 family members, Gas6 ligand, or soluble ectodomains of the members. Live Ebola viruses infected both Axl- and Dtk-expressing cells more efficiently than control cells. Antibody to Axl inhibited infection of pseudotype viruses in a number of Axl-positive cell lines. These results implicate each Tyro3 family member as a cell entry factor in filovirus infection.
|
2022-12-12T22:49:23.391Z
|
27,288,711 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1108/02635570210428294",
"MAG": "2013677517",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The construction industry is plagued by fragmentation of the functions carried out by the various disciplines involved in a project, particularly between the design and construction teams. Concurrent engineering (CE) is seen as a possible means of overcoming this problem. However, for the use of CE to produce the desired benefits, various issues have to be addressed, one of which is the use of appropriate organisational structures. To this effect, this paper explores organisational structures for the implementation of CE in the construction industry. It does so by first reviewing the main principles of, and issues concerning, CE and organisational structures, and by examining the structures which have been proposed for CE by researchers and those which have been used by manufacturing companies in their implementation of CE. By taking into account the peculiarities of the construction industry, this information is used, in conjunction with the results of case studies of companies within the industry, to suggest suitable types of corporate and project level organisational structures to support CE.
|
2022-12-11T09:50:47.374Z
|
240,599,034 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.51171/JMS.V11I1.285",
"MAG": "3199402372",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Rumah yang sehat harus memenuhi kebutuhan fisiologis dan psikologis. Adapun kebutuhan fisiologis antara lain pencahayaan, udara (ventilasi), ruang gerak yang cukup, terhindar dari kebisingan/suara yang mengganggu dan harus memenuhi kebutuhan psikologis yaitu cukup aman dan nyaman bagi masing-masing penghuni rumah dan privasi yang cukup. Perumahan atau pemukiman yang buruk akan menimbulkan masalah kesehatan seperti terjadinya penularan penyakit baik antara anggota keluarga maupun kepada orang lain.
Tujuan dari penelitian ini untuk mengetahui hubungan perilaku penghuni tentang personal hygiene, sanitasi dasar dan kondisi fisik dengan keluhan kesehatan di beberapa rumah kos Kelurahan MacciniMakassar.
Penelitian menggunakan jenis penelitian analitik dengan desain cross sectional, populasinya seluruh penghuni rumah kos di Kelurahan Maccini Makassar. Sampel dalam penelitian ini ada 52 responden dengan metode purposive sampling. Analisis data menggunakan chi-square test. Variabel yang diuji dalam penelitian ini adalah variabel independen yaitu perilaku personal hygiene dan sanitasi dasar, sarana sanitasi dasar dan komponen fisik rumah kos terhadap variabel dependen yaitu keluhan kesehatan.
Hasil penelitian menunjukkan variabel yang berhubungan dengan keluhan kesehatan adalah tindakan personal hygiene p = 0,020 dan tindakan sanitasi dasar p = 0,001. Variabel yang tidak berhubungan adalah pengetahuan p = 0,087 dan sikap p = 0,491 personal hygiene, pengetahuan p = 0,598 dan sikap p = 0,101 sanitasi dasar, komponen fisik kamar kost p = 0,183 dan kelengkapan sarana sanitasi dasar p = 0,991.
Saran bagi penghuni rumah kos agar lebih menjaga personal hygyne, sanitasi dasar, sarana sanitasi dasar yang sudah disediakan dan komponen fisik rumah kos yang ada. Bagi pemilik rumah kos disarankan agar lebih memperhatikan kelengkapan sarana sanitasi dasar dan komponen fisik rumah kos.
|
2022-01-24T23:19:53.523Z
|
19,628,527 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1097/00000446-197008000-00010",
"MAG": "2329519308",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
MRS. ROBERTSON (B.S.N., University of North Carolina, Chapel Hill; M.S.N., University of Minnesota, Minneapolis) is a nursing supervisor at the University of Minnesota Hospitals. The emergency cart was designed by Clarence McKelvey, senior general mechanic in the University of Minnesota Hospitals engineering department. The head nurses involved in the planning included Dianne Bartels, Jan Eide, and Kathy Nixa. Although we tried many different types of carts, we were not satisfied that when a patient emergency occurred on the ward, all the needed supplies, medications, and equipment would be readily available on any of them. In discussing this matter, the head nurses from three medical stations decided a new design was required. Their first concern was the items that should be available on the cart and in what quantities. After reaching agreement among themselves and with the medical staff on the required medications and supplies, they began discussing the cart design. At this point, they realized their need for assistance from the hospital's engineering department. Fortunately, the senior mechanic in the department is very skilled in cabinetry. On their first meeting with him, the nurses outlined their needs-a compact, easily movable cart that could be closed when not in use, but would provide complete visibility and ready accessibility of all medications and supplies, and that would have a working surface for preparing and recording medications. A tall order! It became apparent that the use of any drawers would violate the criteria; on this basis several designs had to be rejected. Finally, the design shown at right was developed. The size of the cart was then determined by collecting, in one room, all the equipment, supplies, and medications the cart would hold and measuring the space required to store them. Thus, on the completely stocked cart,
|
2022-02-12T22:55:19.370Z
|
194,057,440 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3917/sr.027.0067",
"MAG": "2055593291",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://www.cairn.info/load_pdf.php?ID_ARTICLE=SR_027_0067&download=1"
}
|
Au xviiie siecle, les femmes profiterent du desinteret, lie a une forme de mepris de la part des hommes pour les romans, pour investir ce territoire de la litterature, et saisirent rapidement tous les benefices que l’on pouvait tirer d’une forme dont la souplesse permettait d’exprimer leurs idees sur les sujets qui leur tenaient a cœur, et delivrer agreablement des lecons de morale. La production romanesque des auteurs femmes des Lumieres fait apparaitre la presence marquee d’un bestiaire, a la fois outil narratif et motif romanesque qui renseigne sur les mœurs, l’esthetique d’une periode, et sur l’ethique pronee par les romancieres. L’exploitation litteraire de ce motif dans les divers themes abordes par les œuvres s’inscrit plus largement dans la production artistique contemporaine ; la peinture en fournit de nombreux et illustres exemples qui font echo aux textes, riches de vignettes dont l’ecriture autorise le rapprochement avec l’art pictural.
|
2022-08-26T13:34:41.126Z
|
126,203,173 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/00224065.2011.11917863",
"MAG": "2768984921",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In my opinion, the more valuable portions of the book deal with the non-analysis issues such as how to collect your data, ensuring data quality, interpretation of reports and results and finally, good communication of results. Each chapter contains a lengthy bibliography that one can use to dive deeper into any of the subjects covered in the book, which makes it nice for the more familiar reader.
|
2022-09-05T10:26:57.790Z
|
86,891,123 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2331/SUISAN.47.1131",
"MAG": "2320958638",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A demand feeder was designed and constructed for use in the conditioning experiments of fishes, with special attention paid to four points; that (1) it should provide only one pellet when the release mechanism is activated by the fish, (2) its trigger can be activated even by very light touch of the fish, (3) it should be protected from the actions of fishes other than those desired, and (4) it should be possible to manually activate the feeder whenvver needed. By using this device in conjunction with an electromechanical event recorder, a continuous record on the feeding activity of a bluegill sunfish for 10 days was obtained. The observations revealed that the levle of the feeding activity in the fish obtaining food from this device was much lower than that when the fish was fed by the experimenter.
|
2022-09-06T23:45:30.743Z
|
20,401,608 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5005/JP-JOURNALS-10024-1225",
"MAG": "2018105769",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
OBJECTIVES
To correlate the changes in the level of female sex hormones (progesterone, estrogen) in plasma with the changes in severity of gingivitis in various trimesters of pregnancy till the postparturition.
MATERIALS AND METHODS
This study comprised of 20 pregnant women with good oral hygiene who were followed up in each trimester till 3rd month of postpartum by screening their oral hygiene status following OHI-S index by Greene and Vermillion. Clinically to correlate gingivitis, gingival index by Loe and Sillness was carried out in each trimester till postpartum. For hormonal assay, blood sampling by venipuncture was done and quantative analysis of the hormones was done by ELISA test.
RESULTS AND CONCLUSION
The severity of gingivitis gradually increased and reached its peak in 3rd trimester followed by sudden decline in the severity in postpartum which correlated with gradual increase in the plasma level of progesterone and estrogen levels to reach their peak in the 3rd trimester and sudden fall after the postpartum. This study shows the role of female sex hormones in aggravating gingivitis to its peak in the 3rd trimester, even though the oral hygiene remains fairly good constantly.
CLINICAL SIGNIFICANCE
This study signifies the gingivitis status during different trimesters of pregnancy and postpartum indicating the general practitioner to take appropriate oral hygiene measures.
|
2022-09-11T15:14:44.805Z
|
76,652,799 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2528/PIERC16030206",
"MAG": "2509321790",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Transmission zero behavior of two coupled sections — interdigital and combline — is investigated. It is shown that the shifting of transmission zero of any coupled-section of a particular length depends on the width of various parts and the orientation of coupled-section. Mathematical formulation has been performed to show the effect of stepped discontinuity on the transmission zero. Further, this transmission zero allocation property is used in suppression of harmonics. The idea is implemented in two types of resonators — first in parallel-coupled resonators and second in openloop resonators. Two parallel coupled resonator based bandpass filters (BPFs) with second harmonic suppression — one of second-order and the other of fourth-order — using different coupled-sections have been fabricated, and suppression up to −30 dB and −54 dB respectively has been achieved. A fourthorder open-loop resonators based BPF with suppression of undesired passbands up to 6.3fo has been fabricated. Further, the above property is also used to design a dual-band BPF with wide stopband without increasing the size of the filter.
|
2022-12-05T19:27:21.350Z
|
148,675,321 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2478/BJALS-2018-0008",
"MAG": "2968803049",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Abstract This Article recounts my unique adventures in higher education, including being a Princeton University freshman mathematics major at age 14, Harvard University applied mathematics graduate student at age 17, economics and finance faculty at multiple schools, first-year law student at the University of Chicago, second- and third-year law student at Stanford University, and law faculty at multiple schools. This Article also candidly discusses my experiences as student and professor and openly shares how I achieved sustainable happiness by practicing mindfulness to reduce fears, rumination, and worry in facing adversity, disappointment, and setbacks. This Article analyzes why law schools should teach law students about happiness and mindfulness. This Article discusses how to teach law students about happiness and mindfulness. Finally, this Article provides brief concluding thoughts about how law students can sustain happiness and mindfulness once they graduate from law school.
|
2022-12-10T09:18:24.328Z
|
23,993,986 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2214/AJR.139.1.149",
"MAG": "2000126013",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Medullary carcinoma of the thyroid is a unique neoplasm characterized by consistent production of a hormonal marker, calcitonin, calcification of both primary and metastatic foci, and association with other endocrine neoplasms. It accounts for 3.5%--10% of all thyroid malignancies. First described by Hazard et al. [1] in 1959, this neoplasm has become the focus of increasing clinical and experimental investigation. It occurs both sporadically and in families. When familial, it is seen as a component of the multiple endocrine neoplasia type II (MEN-II) syndromes. Interest in medullary carcinoma of the thyroid far exceeds that warranted by its infrequent occurrence. Over 200 articles dealing with this tumor have appeared in the medical literature in the last 10 years. This may be attributed to the number of distinctive properties of the tumor: the familial occurrence when associated with endocrinopathies, the propensity to produce amyloid, and the great synthetic capability for the biogenic amines calcitonin, serotonin, histaminase, and prostaglandins. Of greatest importance is the value of calcitonin radioimmunoassay for detecting patients with the tumor even though it may be evident clinically. Fifty-three patients with surgically and biochemically proven medullary carcinoma were evaluated and followed at Duke University Medical Center from 1968 to 1981. Ten patients with sporadic tumor, 37 with MEN type IIa, and six with MEN type IIb prompted this review. They will be used to illustrate the varied and sometimes characteristic radiographic manifestations of medullary carcinoma of the thyroid. This tumor has a spectrum of radiographic features in multiple organs that, when familial, facilitate its recognition and treatment.
|
2022-12-18T12:43:56.643Z
|
143,062,007 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1108/02634500110363790",
"MAG": "1970905456",
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
The term satisfaction is a very important concept in marketing and is central to many definitions. This paper seeks to examine what this term means to the public at large. It explores the various definitions of satisfaction within the literature. The empirical results derive from individuals’ own interpretation and definition of the term satisfaction, as well as evaluation of their definitions. Finds that most people cited several definitions of satisfaction, illustrating that it is a multifaceted concept. The most common interpretations reflect the notion that satisfaction is a feeling which results from a process of evaluating what was received against that expected, the purchase decision itself and/or the fulfilment of needs/wants. It also finds that the particular interpretation is affected by contextual issues, such as whether it is a product or service under consideration. Implications for consumer satisfaction measurement and interpretation are discussed.
|
2022-12-25T13:02:33.853Z
|