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110,004,999 |
{
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"DOI": "10.1109/TPGPT.1959.1135874",
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|
An outline is presented of the analysis, engineering study, and theoretical investigation of the steady-state vibrations and the sudden-impulse-shock dynamic characteristics of a new military airborne gimbaled system. A mathematical model is described which consists of three mathematical regimes--each defining the distribution of dynamic masses and motions for one plane of excitation. Comprehensive recursion tables for the three regimes were filled out by the high-speed No. 704 Digital Computer. Dynamic-equation matrix coefficients were determined for each frequency. Where the error function was zero, the recursion tables were filled out to determine true mode shapes and distributions. Additional programming determined forcing-function responses and, through the use of open parameters, determined the effects of modifying masses and other elements of the system. Aerodynamic loads for extreme flight conditions were rigorously investigated, and margins-of-safety were determined. It is reported that this mathematical method led to recommendations for weight savings, as well as improvement in the dynamic characteristics of the system.
|
2022-02-10T05:33:15.398Z
|
92,631,307 |
{
"externalids": {
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"DOI": "10.21071/AZ.V65I249.434",
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|
The editorial process of Archivos de Zootecnia during 2015 is reported below. A total of 345 manuscripts coming from 24 countries, mainly from Brazil (almost 70 %), were received. Consequently, the most frequently used language in the manuscripts was Portuguese, followed by Spanish and English. 71 works were published in 2015: 54 articles, 13 short notes and 4 reviews. Published writings came from 15 countries. The two main topics the articles were about were Feeding and food (n= 36, 40 %) and Breeding and genetics (n= 19, 21.1 %); while the most frequent species the works dealt with was cattle (n= 24, 26.67 %). Editorial times between the reception and publication of the manuscripts have comparatively improved according to the results showed in previous years’ reports.
|
2022-02-10T18:07:06.151Z
|
23,101,202 |
{
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"ArXiv": null,
"DOI": "10.1097/00005768-200109000-00014",
"MAG": "1494047342",
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"url": null
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|
PURPOSE
Most studies that use either a single exercise session, exercise training, or a cross-sectional design have failed to find a relationship between exercise and plasma lipoprotein(a) [Lp(a)] concentrations. However, a few studies investigating the effects of longer and/or more strenuous exercise have shown elevated Lp(a) concentrations, possibly as an acute-phase reactant to muscle damage. Based on the assumption that greater muscle damage would occur with exercise of longer duration, the purpose of the present study was to determine whether exercise of longer duration would increase Lp(a) concentration and creatine kinase (CK) activity more than exercise of shorter duration.
METHODS
Ten endurance-trained men (mean +/- SD: age, 27 +/- 6 yr; maximal oxygen consumption [VO(2max)], 57 +/- 7 mL x kg(-1) x min(-1)) completed two separate exercise sessions at 70% VO(2max). One session required 800 kcal of energy expenditure (60 +/- 6 min), and the other required 1500 kcal (112 +/- 12 min). Fasted blood samples were taken immediately before (0-pre), immediately after (0-post), 1 d after (1-post), and 2 d after (2-post) each exercise session.
RESULTS
CK activity increased after both exercise sessions (mean +/- SE; 800 kcal: 0-pre 55 +/- 11, 1-post 168 +/- 64 U x L(-1) x min(-1); 1500 kcal: 0-pre 51 +/- 5, 1-post 187 +/- 30, 2-post 123 +/- 19 U x L(-1) x min(-1); P < 0.05). However, median Lp(a) concentrations were not altered by either exercise session (800 kcal: 0-pre 5.0 mg x dL(-1), 0-post 3.2 mg x dL(-1), 1-post 4.0 mg x dL(-1), 2-post 3.4 mg x dL(-1); 1500 kcal: 0-pre 5.8 mg x dL(-1), 0-post 4.3 mg x dL(-1), 1-post 3.2 mg x dL(-1), 2-post 5.3 mg x dL(-1)). In addition, no relationship existed between exercise-induced changes in CK activity and Lp(a) concentration (800 kcal: r = -0.26; 1500 kcal: r = -0.02).
CONCLUSION
These results suggest that plasma Lp(a) concentration will not increase in response to minor exercise-induced muscle damage in endurance-trained runners.
|
2022-12-11T21:47:58.436Z
|
236,675,523 |
{
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"DOI": "10.37058/JP3M.V7I1.2804",
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|
Penelitian ini ditujukan guna menganalisis dan mendeskripsikan kemampuan berpikir kritis matematis siswa kelas X SMK Negeri 1 Kudus berdasarkan tingkat self-confidence yang dimiliki. Subjek yang digunakan yaitu 3 peserta didik kelas X jurusan Akuntansi SMK Negeri 1 Kudus dimana ketiganya memiliki tingkat kepercayaan diri yang berbeda, yaitu tinggi, sedang, dan rendah. Penelitian ini merupakan penelitian eksploratif dengan pendekatan deskriptif kualitatif. Pengumpulan data dilakukan dengan memberikan angket self-confidence, tes kemampuan berpikir kritis, serta wawancara. Untuk menganalisis data, teknik yang digunakan yaitu reduksi data, penyajian data, dan penarikan kesimpulan. Sedangkan untuk keabsahan data digunakan teknik triangulasi waktu. Dari penelitian ini dapat ditarik kesimpulan bahwa semakin tinggi tingkat self-confidence peserta didik maka semakin baik pula kemampuan berpikir kritis matematis peserta didik tersebut, begitupun sebaliknya.
|
2022-12-16T04:29:20.056Z
|
24,939,683 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.3892/OR.8.5.1139",
"MAG": "2048758055",
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|
The cytologic findings of the tumor cells characteristic of the stages of thymomas were investigated to assess the invasiveness of the tumors. Forty-six patients with thymoma who underwent extensive thymectomy without pre-operative corticosteroid therapy were included in this study. The histologic subtypes included 18 round/oval, 20 mixed, and 8 spindle type. The stages of thymoma classified according to Masaoka's clinicopathological classification included 16 stage I, 20 stage II, 6 stage III, 2 stage IVa, and 2 stage IVb, and myasthenia gravis was recognized in 5 patients. Cytologic findings were retrospectively analyzed in the Papanicolaou-stained stamp smears obtained from the cut surfaces of thymoma specimens. Morphometry of the epithelial tumor cells using Cosmozone-1A was performed to evaluate the validity of our cytologic categories. Compared with the cytologic findings of stage I or II thymomas, those of epithelial tumor cells in stage III or IV more frequently showed necrotic background (50.0%-stage III or IV vs 11.1%-stage I or II, p=0.006), large clusters of epithelial tumor cells (70.0% vs 36.1%, p=0.055), marked nuclear enlargement (90.0% vs 52.7%, p=0.033), marked anisokaryosis (100% vs 52.7%, p=0.006), marked nuclear polymorphism (40.0% vs 5.5%, p=0.004), hyperchromasia (50.0% vs 11.4%, p=0.007) and prominent nucleoli (50.0% vs 16.6%, p=0.028) whereas no significant correlation was observed between cytologic findings and tumor volume. Morphometric studies of thymoma tumor cells revealed that the nuclear size (mean values, 78.8 microm(3)-stage III or IV vs 58.2 microm(3)-stage I or II), the coefficient of variation of the nuclear size (0.326 vs 0.282), and the nuclear rotundity (0.849 vs 0.858) differed significantly between the two categories (p<0.05). Our findings demonstrated that there were significant differences between the cytologic findings of epithelial tumor cells of stage I or II thymomas and those of stage III or IV thymomas, and that the cytologic findings of thymoma tumor cells appear to be useful for distinguishing between non-invasive and invasive thymomas.
|
2022-12-18T13:51:41.307Z
|
249,733,046 |
{
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"ArXiv": null,
"DOI": "10.37550/tdmu.ejs/2022.02.284",
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"license": null,
"status": "BRONZE",
"url": "https://ejs.tdmu.edu.vn/uploads/paper/files/6-Ha-Van-Du.pdf"
}
|
Generation of electricity from wind power a renewable energy source, is continually attracting the attention of investors, researchers and electrical utilities. It has been predicted that the annual growth of wind power between 1998 and 2040 would be between 20% and 30%. This shows the increase in impact of the wind power generator to power system and the importance of understanding the behavior power wind generator following fault conditions that may develop at any point on the hosted network and consequently may affect the stability, the security as well as the quality of power system. Hence, the searching Stability of power system with connection of power wind generator is continually attracting the attention of researchers in the world. This paper displays the Surveying Stability of power system with connection of power wind generator when occurred the fault short circuit on the power system. The investigation is illustrated with network included 12 bus.
|
2022-12-21T18:37:43.464Z
|
4,175,722 |
{
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"ArXiv": null,
"DOI": "10.1080/21678421.2018.1452946",
"MAG": "2792941949",
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"license": null,
"status": "GREEN",
"url": "https://europepmc.org/articles/pmc6141014?pdf=render"
}
|
Abstract In addition to muscle weakness, amyotrophic lateral sclerosis (ALS) is associated with an increased incidence of skeletal fractures. The SOD1G93A mouse model recapitulates many features of human ALS. These mice also exhibit decreased bone mass. However, the functional, or biomechanical, behavior of the skeleton in SOD1G93A mice has not been investigated. To do so, we examined skeletal phenotypes in end-stage (16-week-old) SOD1G93A female mice and healthy littermate female controls (N = 9–10/group). Outcomes included trabecular and cortical bone microarchitecture by microcomputed tomography; stiffness and strength via three-point bending; resistance to crack growth by fracture toughness testing; and cortical bone matrix properties via cyclic reference point indentation. SOD1G93A mice had similar bone size, but significantly lower trabecular bone mass (–54%), thinner trabeculae (–41%) and decreased cortical bone thickness (–17%) and cortical area (–18%) compared to control mice (all p < 0.01). In line with these bone mass and microstructure deficits, SOD1G93A mice had significantly lower femoral bending stiffness (–27%) and failure moment (–41%), along with decreased fracture toughness (–18%) (all p < 0.001). This is the first study to demonstrate functional deficits in the skeleton of end-stage ALS mice, and imply multiple mechanisms for increased skeletal fragility and fracture risk in patients in ALS. Importantly, our results provide strong rationale for interventions to reduce fracture risk in ALS patients with advanced disease.
|
2022-12-30T18:43:12.508Z
|
220,188,060 |
{
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"ArXiv": null,
"DOI": "10.1136/bmj.2.3183.1122",
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|
EDUCATION OF THE DEAF CHILD. -PERHAPS no part of the field of observation open to the medical man has been more generally and more persistently neglected than that occupied by little deaf children. For almost the whole of our era these children have been neglected by society and considered a race apart, and even when grown up denied the right of common law and citizenship. For a hundred and fifty years the teacher of the deaf has been at work and the deaf child is now recognized not only as one of ourselves but as fit to receive all we
|
2022-01-27T07:00:58.953Z
|
86,963,966 |
{
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"ArXiv": null,
"DOI": "10.3181/00379727-25-4091",
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|
Although many experiments have been performed which have shown that the antiseptics have a weaker action in blood serum and tissue juice than in water salt solution or bouillon, this diminution of action has always been ascribed to the presence of the proteins. However, since these fluids also contain lipoids, and since, as has been shown by Cruikshank, 1 Loewe 2 and others, the lipoids may play a decided rôle in altering the distribution coefficient of the antiseptic dyes, we have studied the effects of the mere presence of lipoids upon the action of various antiseptics. In the experiments which we have performed, we have found that when cultures of Staphylococcus aureus and Bacillus coli are exposed to the action of various antiseptics (acriflavine, pyridium, phenol, bichloride of mercury) in suspensions of 0.5% lecithin or kephalin, or of .05% cholesterol, the antiseptic activity was greatly weakened; and this decrease of effectiveness is of about a degree similar to that which is brought about by the presence of an equal concentration of protein, though usually somewhat less marked. Since blood plasma contains .25% lecithin and .18% cholesterol, suspensions which we have used are quite comparable to blood plasma. The table below gives the greatest dilution in Clark's buffer solutions (Na2HPO4+KH2PO4 at pH 7.4) of the antiseptics which inhibited the growth of transplants to agar after the bacteria have been exposed to the action of the antiseptic for 3 hours. The experiments with pyridium were done in Locke's solution as the antiseptic is precipitated by the phosphate buffer at pH 7.4. Longer exposure to these antiseptics gave commensurate results except in the case of acriflavine and cholesterol, in which the control showed no growth in 1:54,000 after 12 hours and 1:500,000 after 24 hours, while in the presence of .05% cholesterol, inhibition occurred in 1:16,000 after 12 hours, and in 1:100,000 after 24 hours. These results were obtained even in the absence of any visible flocculation of the lipoid suspension. We have also observed with the ultramicroscope the effect of antiseptic on lipoid emulsions. The quinine series give blue or greenish Tyndall cones, though no particles can be seen. Lecithin emulsion shows large slowly moving particles. With addition of quinine, for instance, the particles may be seen to form large clumps, and clots are formed, while the blue Tyndall cone becomes weaker, and if sufficient lecithin is added, disappears. Similar results are obtained with the yellow cone of acriflavine.
|
2022-01-27T09:43:26.737Z
|
226,930,063 |
{
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"DOI": "10.3760/CMA.J.ISSN.1008-6706.2017.15.007",
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|
Objective
To detect and analyze nuclear factor kappa B (NF-κB), Helicobacter pylori (HP), Helicobacter pylori cytotoxin associated protein A (CagA), platelet (PLT) and platelet associated IgG (PA IgG) in 224 patients with idiopathic thrombocytopenic purpur(ITP) from three urban hospitals of Shaoxing, in order to explore the role of NF-κB and CagA in the pathogenesis of ITP, then to improve the prognosis of ITP.
Methods
SABC method was used to detect the NF-κB, 13C breath test for the determination of the Hp infection.CagA and PA-IgG were tested by enzyme linked immunosorbent assay.Automatic blood cell analyzer was used to measure PLT.According to the test results, the patients were divided into Hp+ cagA+ NF-κB+ , Hp+ cagA+ NF-κB-, Hp+ cagA-NF-κB+ , Hp+ cagA-NF-κB-, Hp-NF-κB+ , Hp-NF-κB-PLT groups, and PA-IgG, PLT of the six groups were statistically analyzed.
Results
Of 224 cases with ITP, 175 cases of HP positive, the positive rate was 78.13%.CagA+ 91 cases in 175 cases of Hp+ , accounting for 52%, overall 43.63%.NF-kappa B+ 108 cases, the positive rate was 46.21%, 78 cases were found in Hp+ cagA+ , accounting for 85.71% in cagA+ .In 84 cases of Hp+ cagA-, there were 21 cases NF-κB+ , the positive rate was 25%.In 49 of HP-, 9 cases with NF-kappa B+ , accounting for 18.37%.PLT and PA-IgG were compared among the groups.The count of PLT of group Hp+ , group Hp+ cagA+ and group NF-κB+ was lower than group Hp-, group Hp+ cagA- and group NF-κB-.However, the level of PA-IgG of group Hp+ , group Hp+ cagA+ and group NF-κB+ was higher than group Hp-, group Hp+ cagA- and group NF-κB-, the difference was statistically significant(P<0.05).
Conclusion
CagA maybe directly or through the activation of NF-kappa B take part in the immune response of ITP, cause PA-IgG increased and thrombocytopenia.
Key words:
Helicobacter pylori; Cytotoxin-associated protein; Nuclear factor-kappa B; Purpur, thrombocytopenic
|
2022-02-07T23:42:44.814Z
|
57,192,975 |
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"DOI": "10.5195/jmla.2019.351",
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"PubMedCentral": "6300228"
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"license": "CCBY",
"status": "GOLD",
"url": "https://jmla.pitt.edu/ojs/jmla/article/download/351/769"
}
|
Background This case study describes the implementation and evaluation of a multisite teen health information outreach program. The objectives of the program were to increase health knowledge, health information literacy, interest in health careers, community engagement, and leadership skills of teens in disadvantaged communities. Case Presentation Teens at six sites across the country participated in a multi-week curriculum that focused on various aspects of health literacy, information literacy, and leadership. Lesson topics addressed personal health, social determinants of health, information quality, and communication and advocacy skills. Program evaluation included both quantitative and qualitative components and focused on multiple knowledge and skills outcome variables. Results suggested that while teens at all sites showed improvement, particularly with respect to engagement and interest in the topics, the degree of gains in knowledge and information literacy measures varied significantly from site to site. Conclusion On-site implementation planning, cohesive integration of added activities, and emphasis on retention can contribute to implementation and evaluation effectiveness. This work also underscores the limitation of a purely quantitative approach to capturing the impact of health information and stresses the importance of supplementing numerical scores and statistics with qualitative data.
|
2022-02-11T18:11:12.761Z
|
248,550,647 |
{
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"DOI": "10.1088/1742-6596/2264/1/012009",
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"license": null,
"status": "GOLD",
"url": "https://doi.org/10.1088/1742-6596/2264/1/012009"
}
|
Employing unmanned aerial vehicle (UAV) in fiber-based visible light communication (FVLC) can not only enhance the flexibility of visible light communication, but also provide users with sufficient lighting conditions. In the downlink UAV-assisted FVLC (UFVLC) system based on power domain non-orthogonal multiple access (PD-NOMA), the outdoor weak-turbulence channel environment is considered in this paper, where the UAV is set as a communication relay. We have analysed the distribution function of received signal and system noise in the actual environment, derived the calculation formulas of noise and signal-to-noise ratio (SNR). The theoretical bit error rate (BER) expression of the UFVLC system is derived by analysing the influence of UAV and receiver position. Moreover, numerical results demonstrate that the theoretical analysis is consistent with the simulation results, especially in the case of high SNR.
|
2022-05-14T03:18:03.528Z
|
90,423,959 |
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"DOI": "10.18174/399601",
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"status": "BRONZE",
"url": "https://edepot.wur.nl/399601"
}
|
The ornamental geophyte Tulipa gesneriana is the most cultivated bulbous species in the Netherlands. It is widely grown in the field for vegetative propagation purposes and in greenhouses for the production of high quality cut flowers. Over the last decade, the tulip bulb industry is affected by the rapid climate change the world is facing. Temperature is rising and influences the vegetative to reproductive phase change (floral induction) inside the tulip bulbs in spring and processes that are occurring during winter, such as dormancy release. In this thesis the two temperature-dependent processes related to tulip flowering, being floral induction and dormancy release, were investigated in detail with a special focus at the molecular level. Flowering time has been studied in a broad range of species, including the model species Arabidopsis thaliana and Oryza sativa. The current understanding of this process can be translated to non-model species, such as tulip, through a ‘bottom-up’ and ‘top-down’ approach (Chapter 2). For the ‘bottom-up’ approach conservation of molecular pathways is assumed and researchers make use of sequence homology searches to identify candidate genes. The ‘top-down’ approach starts from large scale data mining, such as RNA-sequencing (RNA-seq) data or microarrays, followed by the association between phenotypes, genes and gene expression patterns. Here, a comparison with data from model plant species is made at the end of the process and this also leads to the identification of candidate genes for a particular process. Large scale genomics data mining in tulip is only possible via transcriptome analysis with RNA-seq derived data, because no full genome-sequence is present at this moment. Genome sequencing remains a challenge for species with a large and complex genome, containing probably a large number of repetitive sequences, which is the case for tulip and lily. In chapter 3 a high quality transcriptome of tulip and lily is presented, which is derived from a collection of different tissues. In order to obtain good transcriptome coverage and to facilitate effective data mining, different filtering parameters were used. This analysis revealed the limitations of commonly applied methods used in de novo transcriptome assembly. The generated transcriptome for tulip and lily is made publicly available via a user friendly database, named the ‘Transcriptome Browser’. The molecular regulation of the temperature-dependent floral induction was studied through the use of RNA-seq (Chapter 4). A better understanding of this process is needed to prevent floral bud blasting (dehydration of the flower) in the future. The development at the shoot apical meristem (SAM) was morphologically investigated in two contrasting temperature environments, high and low. Meristem-enriched tissues were collected before and during the start of flower development. The start of flower development is morphologically visible by rounding of the SAM and correlates with the up-regulation of TGSQA, an AP1-like gene. A ‘top-down’ approach was used to identify possible regulators of the floral induction in tulip. However, Gene ontology (GO)-enrichment analysis of the differentially expressed genes showed that the floral induction, maturation of the bulb and dormancy establishment are occurring around the same period in time. Therefore a ‘bottom-up’ approach was followed to identify specific flowering time regulators based on knowledge obtained from other species. Expression analysis in tulip, heterologous analysis in Arabidopsis and yeast two hybrid-based protein-protein interaction studies revealed that Tulipa gesneriana TERMINAL FLOWER 1 (TgTFL1) is likely a repressor of flowering, whereas Tulipa gesneriana SUPPRESSOR OF OVEREXPRESSION OF CONSTANS-LIKE2 (TgSOC1L2) acts probably as a floral activator. Another well-known flowering time regulator is FLOWERING LOCUS T (FT), which is a member of the PEBP gene family found in Arabidopsis and many more plant species. In tulip and lily, a total of four highly similar sequences to FT and HEADING DATA 3A (Hd3a) were identified (Chapter 5). Overexpression of Lilium longiflorum FT (LlFT) and TgFT2 in Arabidopsis resulted in an early flowering phenotype, but upon overexpression of TgFT1 and TgFT3 a late flowering phenotype was observed. The tulip PEBP genes TgFT2 and TgFT3 have a similar expression pattern during development, but show a different behaviour in Arabidopsis. Therefore the difference within the amino acid sequence was investigated, which resulted in the identification of two important amino acids for the FT function, which appeared to be mutated in TgFT3. Interchanging of these amino acids between TgFT2 and TgFT3 resulted in conversion of the phenotype, showing the potential importance of these positions in the protein and these specific amino acids for the molecular mode of action of these two proteins. Based on all the data, LlFT is considered to play a role in creating meristem competency to flowering related cues and TgFT2 to act as a florigen involved in the floral induction. The function of TgFT3 is not clear, but phylogenetic analysis suggests a bulb specific function. After the floral induction and completion of flower development inside the tulip bulb, a period of prolonged cold is required for proper flowering in spring. Low temperature stimulates the re-mobilization of carbohydrates from the scale tissues to the sink organs, such as the floral stem, floral bud and leaves. Not many details are known about the molecular and metabolic changes during this cold period. In chapter 6, first insights are shown on the development of the different tissues inside the bulbs. The floral bud appears to be the least active tissue in comparison with the floral stem and leaves, suggesting a type of floral bud dormancy in tulip. However, metabolic changes are suggesting that the floral bud is still showing active cell division and/or preparation for elongation by turgor-driven cell wall extension. Dormancy of all tissues seems to be released ten weeks after planting and is correlated with the increase of glucose levels. In the leaves, from this same moment, photosynthesis related genes are up-regulated suggesting that the leaves are preparing for photosynthesis while still beneath the soil surface. At the end of the thesis a glance is given at different perspectives of the tulips life cycle, categorizing tulip as a perennial, biennial or annual plant species, respectively. The perennial way of life is applicable when growing bulbs from seeds, while biennial and annual are more in relation to vegetative propagation. Also the importance of bulb size is highlighted, because it will determine if the bulbs are able to flower or not the following spring. Two scenarios are discussed related to availability of energy in the presence of carbohydrates and meristem incompetency to floral inducing signals. Throughout all research done for this thesis, it became clear that tulip bulbs and seeds have a lot in common. By combining the knowledge of processes in different plant species or developmental systems it is possible to understand how flowering and dormancy release are regulated and this provides us with novel insights how these processes are regulated in bulbous plant species, such as tulip.
|
2022-08-24T22:32:01.912Z
|
73,341,601 |
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Abstract Objective: To evaluate the efficacy of transdermal scopolamine for treatment of postoperative nausea and vomiting (PONV) after robotic-assisted gynecologic surgery. Design: Prospective, randomized, double-blinded, placebo-controlled clinical trial. Method: Overall, 47 patients underwent robotic-assisted gynecologic surgery at two tertiary care hospitals, and they were randomized to receive transdermal scopolamine or placebo preoperatively. They then completed a series of questionnaires utilizing a visual analogue scale to rate their nausea and vomiting. Main outcomes were severity of nausea and vomiting till 72 hours postoperatively. Secondary outcomes were antiemetic use, time to discharge, effect on patient well-being of PONV, and patient overall well-being. Results: There was a benefit to the number of rescue antiemetics administered in the immediate postoperative period (0.30 vs. 0.70, p=0.026), but no significant reduction in incidence or severity of PONV, no overall decrease in amount of an...
|
2022-09-03T13:55:32.842Z
|
137,104,518 |
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"DOI": "10.4028/www.scientific.net/MSF.539-543.4891",
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|
Transformation of austenite to martensite during cold rolling operations is widely used to strengthen metastable austenitic stainless steel grades. Static strain aging (SSA) phenomena at low temperature, typically between 200°C and 400°C, can be used for additional increase in yield strength due to the presence of α’-martensite in the cold rolled metastable austenitic stainless steels. Indeed, SSA in austenitic stainless steel affects mainly in α’-martensite. The SSA response of three industrial stainless steel grades was investigated in order to understand the aspects of the aging phenomena at low temperature in metastable austenitic stainless steels. In this study, the optimization of, both, deformation and time-temperature parameters of the static aging treatment permitted an increase in yield strength up to 300 MPa while maintaining an acceptable total elongation in a commercial 301LN steel grade. Deformed metastable austenitic steels containing the “body-centered” α’-martensite are strengthened by the diffusion of interstitial solute atoms during aging at low temperature. Therefore, the carbon redistribution during aging at low temperature is explained in terms of the microstructural changes in austenite and martensite.
|
2022-09-07T02:36:57.693Z
|
12,485,174 |
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"DOI": "10.1109/INFOCOMMST.2017.8246453",
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}
|
Denial of service (DOS) attack is an attack which the attacker or attackers make an effort to make a service or resources out of access. If attackers want to intensify the power of the attack or stay undetected they might use Distributed DOS (DDOS) methods. Application layer DOS (ADOS) attacks are exploiting a flaw in a software, therefore they need fewer resources on the attacker side, hard to detect and also stronger hardware on the victim side doesn't guarantee the attack failed. Slow HTTP attacks are ADOS attack in which they take advantage of the architecture of HTTP protocol connection's mechanism and target the vulnerable web servers. There has been much research about ways to prevent the Slow HTTP DOS attacks, but none of these studies have considered the impact of such DOS and DDOS attack on the virtual environment which is the core of cloud computing. One of the main question that this paper is trying to solve is, what impacts Slow HTTP DOS and DDOS can cause on a virtual machine (VM) also on the neighbor VM, In this paper, we demonstrate and analyze the direct and indirect impact of the slow HTTP DOS and DDOS on the virtual environment. we will launch the Slowloris DOS and DDOS on VMs and analyze the direct impact of the attack on the target VM also the indirect impact of the attack on the neighbor VM.
|
2022-10-03T13:38:21.473Z
|
153,172,207 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5860/choice.192973",
"MAG": "1177081701",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
By examining the history of the legal regulation of union actions, this fascinating book offers a new interpretation of American labor-law policy-and its harmful impact on workers today. * Provides a unique interpretation of labor law from a multidisciplinary perspective that encompasses history, politics, economics, culture, and psychology * Considers the role organized labor played in creating the American middle class and what role it might play in the future * Shows the adverse consequences of the contemporary right-to-work movement * Examines the politicized nature of law in America * Offers recommendations for political action to restore union vitality
|
2022-10-31T05:48:07.083Z
|
20,574,351 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1309/AJCP6US3ILGEAREE",
"MAG": "2142875726",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Overcrowding and prolonged patient length-of-stay (LOS) in emergency departments (EDs) are growing problems. We evaluated the impact of implementing a rapid whole blood quantitative D-dimer test (Biosite Triage, Biosite Diagnostics, San Diego, CA) in our ED satellite laboratory on 252 patients before vs 211 patients after implementation. All patients also underwent testing with the existing central laboratory method (VIDAS D-dimer, bioMérieux, Durham, NC). D-dimer turnaround time (from blood draw to result) decreased approximately 79% (approximately 2 hours vs 25 minutes). The mean ED LOS declined from 8.46 to 7.14 hours (P = .016). Hospital admissions decreased 13.8%, ED discharges increased 7.3%, and the number of patients admitted for observation increased 6.4% (P = .005). No difference in the utilization of radiologic studies was observed (P = .86). At 3 months' follow-up, none of the after-implementation patients with negative D-dimer results were admitted for subsequent venous thromboembolic disease. The rapid D-dimer test was associated with a shorter ED LOS and fewer hospital admissions.
|
2022-12-23T02:07:24.487Z
|
109,120,867 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/stc.1808",
"MAG": "1941535912",
"PubMedCentral": null
},
"license": null,
"status": "GOLD",
"url": "https://doi.org/10.1002/stc.1808"
}
|
The equivalent force control (EFC) method has been developed for real‐time hybrid testing to replace the numerical iteration of implicit integration with a force‐feedback control loop. With this control loop, the EFC method can also compensate for the time delay in real‐time hybrid testing. However, the delay compensation effect of the EFC can be influenced by factors such as noises in the measured displacement. This paper discusses the influence of the measurement noises on real‐time hybrid testing with the EFC. The Kalman filter is proposed to filter the noises in the measured actuator displacement for improved performance. A higher proportional gain in the PID controller, which improves the effect of time delay compensation of the EFC method, can be allowed without losing stability when incorporating the Kalman filter. A series of real‐time hybrid tests were conducted, and the results validated that the EFC method with Kalman filter can effectively compensate for the time delay. Copyright © 2015 John Wiley & Sons, Ltd.
|
2022-12-30T01:20:04.661Z
|
26,253,175 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1128/iai.51.3.948-952.1986",
"MAG": "1914725721",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "https://europepmc.org/articles/pmc260991?pdf=render"
}
|
The polypeptide compositions and antigenic components of Rickettsia tsutsugamushi were analyzed by modifying the solubilization conditions prior to polyacrylamide gel electrophoresis and by using monoclonal antibodies in immunoblotting experiments. Several polypeptides were converted to larger or smaller molecules by using various conditions for rickettsial sample preparation. Solubilization of a sample in 2-mercaptoethanol-containing buffer resulted in conversion of high-molecular-weight polypeptides to smaller polypeptides and conversion of some of the 43-kilodalton (43K) polypeptide to a 46K polypeptide. The heat modifiability of selected polypeptides was shown by heating samples at 100 degrees C. A major polypeptide on the rickettsial surface which showed strain-specific antigenicity appeared at the 43K position in samples solubilized at 37 degrees C but moved to the 56K position after samples were heated at 100 degrees C. Immunoblotting with an anti-56K polypeptide monoclonal antibody demonstrated that the reactive antigens existed predominantly as the higher-molecular-weight polypeptides. These polypeptides were converted to 43K polypeptides at 37 degrees C or the 56K polypeptides at 100 degrees C by cleavage of disulfide linkages with 2-mercaptoethanol treatment.
|
2022-08-20T01:42:42.527Z
|
142,368,766 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2307/812766",
"MAG": "261269375",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
place in the English classroom, the question arises: Can a white teacher in any sense at all communicate to his classes what it is, or was, to be an Indian in white America? Although many whites are suddenly discovering an Indian ancestor in their background, the time when every university has a professor with even some Indian blood to teach Indian Studies is in the future, and still further in the future is the time when
|
2022-08-24T23:35:02.213Z
|
11,093,219 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1097/MNM.0b013e328350b3b0",
"MAG": "2313221844",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
ObjectivesTo evaluate the incremental prognostic value of 99mTc-tetrofosmin early poststress lung/heart ratio (eLHR) and to assess the optimal cut-off value. Materials and methodsWe studied 503 patients (aged 61.3 years/SD=8.6 years, 302 men) with stress/rest 99mTc-tetrofosmin myocardial gated-single photon emission computed tomography and coronary angiography. To evaluate myocardial ischemia, the summed stress score, summed rest score, and summed difference score indices were calculated. For the eLHR calculation, an anterior image was acquired 4–6 min after radiotracer injection at stress; eLHR was defined as the mean counts/pixel in the lung region of interest divided by the mean counts/pixel in the myocardial region of interest. The incremental prognostic value of eLHR was evaluated by a significant increase in the global &khgr;2 of the Cox proportional hazard model that included clinical, exercise, angiographic, and scintigraphic variables. Using the receiver operating characteristic analysis, the optimal cut-off of eLHR for the prediction of cardiac events was determined. ResultsDuring the follow-up period, hard cardiac events occurred in 50 (9.9%) and soft cardiac events in 61 (12.1%) patients. Receiver operating characteristic curve analysis showed that the optimal cut-off of eLHR for the prediction of cardiac events was 0.51, with a sensitivity of 78.4% and specificity of 72.2%. The area under the curve was 0.82 (95% confidence interval: 0.77–0.87). Multiple Cox regression analysis revealed that eLHR more than 0.51 (hazard ratio=7.78; 95% confidence interval: 5.00–12.11) provided incremental prognostic value over clinical exercise testing and scintigraphic data for cardiac events. ConclusionA 99mTc-tetrofosmin eLHR value larger than 0.51 added incremental value to other variables for the prediction of cardiac events.
|
2022-09-02T07:51:51.926Z
|
78,007,171 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.18663/TJCL.54874",
"MAG": "2416108418",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Bu derleme yazisinda, koku fizyolojisi ve koku testleri ele alinmistir. Koku, maddelerin havaya surekli yaymi s olduklari ucucu, kimyasal molekullerdir. Koku duyusunun besin maddelerinin taninmasinda, zararli kimyasal maddelerin etkilerinden kacinmada, istekli yemek yemede ve sinir sistemi fonksiyonlarinin duzenlenmesinde rolu vardir. Koku bozukluklari iletimsel, sensorinoral ya da mikst tipte olmaktadir. Koku fonksiyonunu degerlendirmek cok kolay degildir. Bu degerlendirme bircok parametre ile yapilmaktadir. Uygulanan testler psikofizik testler ve elektrofizyolojik testler olarak ikiye ayrilir. Psikofizik testler koku kaybinin klinik degerlendirmesi icin kullanilirken, elektrofizyolojik testler oncelikli olarak arastirma amacli kullanilmaktadir. Koku duyusu bozukluklari, genellikle diger duyu bozukluklari gibi objektif testler ile degerlendirilmemekte; ve klinisyenler tarafindan da ihmal edilmektedir. Bu nedenle bu konunun ilgilendirdigi bolumler olan KBB, Noroloji ve Aile Hekimlerinin muayenesi sirasinda koku gibi duyusal sisteme farkindalik arttirilmasi amaclanmistir. Anahtar kelimeler: Koku, olfaktor sistem, koku fizyolojisi, koku testleri
|
2022-09-06T00:50:44.479Z
|
56,096,603 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.24815/JN.V17I2.8076",
"MAG": "2760642544",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A study on the adsorption characteristic of Iron onto Poly[eugenol-co-(divinyl benzene)] (EDVB) from aqueous solution has been conducted. EDVB was produced and characterized by using FTIR spectroscopy. The adsorption was studied by a batch method by considering the factors affecting the adsorption such as initial metal ion concentration, adsorption selectivity, and mechanism of adsorption using a sequential desorption method. The adsorption of Iron onto EDVB followed a pseudo-2 order kinetics model with the rate constant of 0,144 L2 mmol-1 min-1. The adsorption isotherm was studied with Tempkin, Langmuir and Freundlich models. The adsorption capacity (Qmax) obtained by Langmuir isotherms was 250mg.L-1 while the equilibrium value was 0.8 Lmg-1. A competitive adsorption study showed that EDVB is adsorbed selectively towards Iron rather than Chromium, Coppers and Cadmium ions. The interaction type of Iron onto EDVB was determined by a sequential desorption.
|
2022-09-16T02:46:33.498Z
|
101,074,642 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1021/MA402184W",
"MAG": "2323313656",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
By means of molecular dynamics simulations, we study AB diblock copolymer and nanoparticle mixtures confined between two identical walls in slit geometry. The nanoparticles are selective to the minority A-block, while the walls are neutral to both copolymer and nanoparticle. We obtained the various structures of the copolymer nanocomposites and are summarized in a phase diagram constructed in diblock composition and nanoparticle concentration space. In comparison to the phase diagram in bulk, we observe a much wider lamellar region with a broad class of lamellar structures, and the phase boundaries are shifted with increasing nanoparticle concentration. We find that both vertically and horizontally oriented lamellar structures are realized. The vertically oriented lamellae are formed by slightly asymmetric and symmetric diblock copolymers at low nanoparticle concentrations and have a very limited region of stability in the phase space, whereas the horizontally oriented lamellae are formed by asymmetric co...
|
2022-10-27T16:40:53.086Z
|
145,755,672 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/00913367.1983.10672825",
"MAG": "2086935784",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Abstract Parental influence on third and fourth graders' cognitive, attitudinal, and behavioral responses to TV advertising was explored in structured personal interviews with 222 children and their parents. The dimensions of parental influence addressed were frequency of parent-child interactions about advertising and commercials, and parental control of the child's television viewing habits. Interviews were conducted with children and their parents simultaneously at different locations in the respondents' homes. Frequent parent-child interaction was found to correlate with greater parent-child attitude difference and frequent purchase requests. Support was found for hypothesized relationships between the level of control effort reported by parents and the child's (1) understanding of the nature and purpose of and (2) attitude toward television advertising.
|
2022-11-06T17:31:36.932Z
|
84,400,229 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1590/S0100-67622002000500007",
"MAG": "2017592114",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
An assay was carried out at Sinop, Mato Grosso. Total height, number of wind-damaged plants and biomass yield of Schizolobium amazonicum were evaluated in different populational densities and spacings, at sixty months of age. The results show that height and DBH developments were influenced in the different spacings studied. Forty seven plants were wind-damaged and the 4 x 4m spacing yielded more biomass than the other spacings.
|
2022-12-04T21:22:46.329Z
|
32,969,273 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/HUMU.10164",
"MAG": "2039587468",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
As Human Genome Project exploration continues, the necessity of having a broader spectrum of genomic DNA material from different nationalities to study various aspects of hereditary disease becomes more obvious. The existence of high genetic polymorphism within and between different communities in the world makes it necessary for the gene hunters to investigate many different populations. Iran, a large country with close to 66 million people, is a land of different nationalities, tribes, and religions that offers a highly heterogeneous gene pool to the genetics researcher. The purity of many different races in this country has been highly conserved by geographical borders and by an ancient culture that has always encouraged intrafamilial marriages. All these have created a population that is remarkably heterogeneous yet high in consanguinity rate. During the last five years of investigation we have established a DNA bank, the Iranian Human Mutation Gene Bank (www.IHMGB.com), which contains all genetic diseases studied in Iran that have the Mendelian mode of inheritance. Some of the samples are assigned to common or novel mutations and others belong to patients with clinical profiles associated with particular genetic diseases but undefined mutation. This bank stores samples of DNA from the patient and his/her first‐degree relatives together with a comprehensive pedigree and clinical profile for each sample. To facilitate collaboration with other scientists around the world with the same interests, we decided to present our experimental projects online. This DNA bank provides opportunities for us to collaborate with scientists outside Iran. It offers a sample resource to research scientists around the world, at no charge, for the purpose of investigating the various aspects of genetic disorders from prenatal diagnosis to gene structure and function. It is strongly stressed that no commercial benefit is involved in the establishment of this DNA bank and the DNA samples are free of charge. However, to meet our goals and to respect ethical values, DNA samples can only be used under certain conditions stated in the User Consent Form. Hum Mutat 21:146–150, 2003. © 2003 Wiley‐Liss, Inc.
|
2022-12-12T00:28:09.588Z
|
201,652,307 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1515/zfw.1992.0004",
"MAG": null,
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},
"license": null,
"status": null,
"url": null
}
|
Das rapide Bevölkerungswachstum der Städte in den Entwicklungsländern allgemein und be sonders in Afrika ist vielfältig beschrieben wor den (z.B. O'CONNOR 1983, PEIL/SADA 1984, GUGLER 1989). Das von der Stiftung Volkswagenwerk geförderte Forschungsprojekt „Urbanisierungsprozesse in schwarzafrikani schen Städten" hat sich als Ziel gesetzt, am Beispiel von vier Großstädten unterschiedlicher Größe, Lage, Genese und Stellung im nationa len Städtesystem einige Aspekte dieser damit verbundenen Prozesse vergleichend zu untersu chen.
|
2022-12-15T01:44:20.977Z
|
32,880,189 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1172/JCI117312",
"MAG": "1988071339",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The present study was undertaken to assess the presence of renin enzymatic activity and renin mRNA in proximal tubules of rat kidneys, and to determine the effect of converting enzyme inhibition (CEI) on proximal tubule renin gene expression. Proximal convoluted tubules (PCT), proximal straight tubules (PST), outer medullary collecting ducts (OMCD), and glomeruli (Gloms) were isolated by microdissection. Renin activity was measured in sonicated segments by radioimmunoassay. Renin mRNA levels were assessed using a quantitative PCR. Renin activity in PCT averaged 51 +/- 15 microGU/mm compared to 405 +/- 120 microGU/glomerulus. No measurable renin activity was found in PST and OMCD. Renin activity in both glomeruli and tubules had the same pH optimum, between 7.0 and 7.5. Renin mRNA was consistently detectable in cDNA prepared from PCT and PST, although its abundance per mm tubule was about 1/500th that found in one glomerulus. Renin mRNA was not detectable in OMCD. Tubular renin PCR product identity was confirmed by restriction digestion. CEI administration increased glomerular renin activity and renin mRNA, but not proximal tubular renin. The absence of a stimulatory effect of CEI on proximal tubule renin gene expression suggests the operation of different intracellular signals in control of renin synthesis in the proximal tubule than in the vascular compartment.
|
2022-12-16T09:32:32.855Z
|
30,767,132 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1093/cid/ciu382",
"MAG": "2131453451",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "https://europepmc.org/articles/pmc4809981?pdf=render"
}
|
BACKGROUND
People who inject drugs (PWID) in Dar es Salaam, Tanzania, have an estimated human immunodeficiency virus (HIV) prevalence of 42%-50% compared with 6.9% among the general population. Extensive evidence supports methadone maintenance to lower morbidity, mortality, and transmission of HIV and other infectious diseases among PWID. In 2011, the Tanzanian government launched the first publicly funded methadone clinic on the mainland of sub-Saharan Africa at Muhimbili National Hospital.
METHODS
We conducted a retrospective cohort study of methadone-naive patients enrolling into methadone maintenance treatment. Kaplan-Meier survival curves were constructed to assess retention probability. Proportional hazards regression models were used to evaluate the association of characteristics with attrition from the methadone program.
RESULTS
Overall, 629 PWID enrolled into methadone treatment during the study. At 12 months, the proportion of clients retained in care was 57% (95% confidence interval [CI], 53%-62%). Compared with those receiving a low dose (<40 mg), clients receiving a medium (40-85 mg) (adjusted hazard ratio [aHR], 0.50 [95% CI, .37-.68]) and high (>85 mg) (aHR, 0.41 [95% CI, .29-.59]) dose of methadone had a lower likelihood of attrition, adjusting for other characteristics. Older clients (aHR, 0.53 per 10 years [95% CI, .42-.69]) and female clients (aHR, 0.50 [95% CI, .28-.90]) had a significantly lower likelihood of attrition, whereas clients who reported a history of sexual abuse (aHR, 2.84 [95% CI, 1.24-6.51]) had a significantly higher likelihood of attrition.
CONCLUSIONS
Patient retention in methadone maintenance is comparable to estimates from programs in North America, Europe, and Asia. Future implementation strategies should focus on higher doses and flexible dosing strategies to optimize program retention and strengthened efforts for clients at higher risk of attrition.
|
2022-12-18T13:04:51.393Z
|
36,105,708 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.12968/bjon.2014.23.20.1068",
"MAG": "1994818160",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The Glasgow Coma Scale (GCS) has been accepted nationally and internationally as a tool to assess depth and duration of consciousness since it was published in 1974. Although it was intended to be an easy and practical bedside tool for any grade of health professional, it is considered to be ambiguous and confusing for infrequent users. Moreover, there has been increasing concern about the accuracy and effectiveness of the GCS observation carried out by these users, which could result from lack of training and dissemination of benchmarking across non-specialist areas. This paper aims to introduce a GCS flow chart to guide users step by step when assessing a patient's level of consciousness.
|
2022-12-19T01:54:08.582Z
|
241,144,431 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.31219/osf.io/r24xm",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Yuenan jing ji fa zhan de zheng zhi jing ji xue / Sun Guoxiang zhu.越南经济发展的政治经济学 / 孙国祥 著.Publisher: Taibei Shi : Han lu tu shu chu ban you xian gong si, 2020. 台北市 : 翰芦图书出版有限公司, 2020.Format:BooksPhysical Description: 378 pages ;23 cm.Series Title: Ren shi Yuenan. 认识越南.Notes: Text written in traditional Chinese scripts. 繁体字本.Identifier: (ISBN)9789869974813 (ISBN)9869974813 (OCoLC)1237563973
|
2022-02-07T20:15:20.104Z
|
107,874,647 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.21236/ada249678",
"MAG": "231999569",
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
Abstract : The purpose of this report is to provide a mission and systems requirement analysis for an In-Flight Field Portable Laboratory . This system is to be an additional capability for the USAF Aeromedical Evacuation Mission specifically to evaluate the utility of an In-flight capable Aeromedical Clinical Laboratory to improve aeromedical mission effectiveness. Additional Information concerning the software discussed in Appendix B is available only from Systems Research Laboratories, Incorporated. Aeromedical Clinical Laboratory (AMCL), Aeromedical Evacuation.
|
2022-02-10T07:33:06.760Z
|
240,757,594 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.21203/rs.3.rs-618566/v2",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBY",
"status": "GREEN",
"url": "https://www.researchsquare.com/article/rs-618566/latest.pdf"
}
|
The present work was aimed to evaluate the effect of valproic acid(VPA)，Silibinin (SIM)+VPA on Ti rods osseointegration in ovariectomized rats and further investigation of the possible mechanism. The MC3T3-E1 cells were co-cultured with VPA，SIM +VPA and induced to osteogenesis, and the cell viability，mineralization ability were observed by MTT and ALP staining，Alizarin Red staining and Western blotting. Twelve weeks after bilateral ovariectomy, all animals were randomly divided into four groups: group OVX and VPA，SIM +VPA, and all the rats received Ti implants and animals belong to group VPA，SIM +VPA received valproic acid(300 mg/kg/day), valproic acid(300 mg/kg/day) plus SIM (25mg/kg/day) , respectively, treatment until death at 12 weeks. Micro-CT, histology, biomechanical testing, bone metabolism index and Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) analysis were used to observe the therapeutic effect and explore the possible mechanism. Results shown that VPA decreased new bone formation around the surface of titanium rods and push-out force other than group OVX. Histology, Micro-CT and biochemical analysis results showed combined application of systemic VPA showed harmful effects than OVX group on bone formation in osteopenic rats, with the worse effects on CTX-1, P1NP and microarchitecture as well as biomechanical parameters by down-regulated gene expression of Runx2, OCN, Smad1, BMP-2 and OPG, while up-regulated RANKL. However, after SIM treatment, the above indicators were significantly improved. The present study suggests that systemic use of VPA may bring harm to the stability of titanium implants in osteoporosis, SIM can reverse the negative effect of VPA on the osseointegration of titanium rods in ovariectomized rats.
|
2022-04-15T01:09:13.474Z
|
234,600,394 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.25728/ASSA.2020.20.3.977",
"MAG": "3143045460",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A two-level dynamical game theoretic model "federal state - universities" in open-loop strategies is built and investigated. A refinement of the electronic learning courses, and their differentiation using modern methods of information technologies made by competing a la Cournot universities (agents) are treated as innovative investments. The algorithms of building Nash (in the non-coalitional game of agents) and Stackelberg (in the hierarchical game of the Principal with the grand coalition of agents) equilibria are proposed and implemented. For the solution of the respective dynamic control problems the Pontryagin maximum principle and simulation modeling are used. A comprehensive analysis of the received results is given.
|
2022-08-09T15:40:03.813Z
|
239,787,950 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.21009/segar/0701.01",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "http://journal.unj.ac.id/unj/index.php/segar/article/download/9198/6245"
}
|
Penelitian ini bertujuan untuk mendeskripsikan batasan nilai atau norma untuk komponen pembibitan olahraga pada anak madrasah ibtidaiyah dengan rentang nilai 10 hingga 12 tahun baik dalam bentuk komponen antropometrik maupun fisik. Rancangan penelitian yang digunakan pada penelitian ini adalah Deskriptif Kuantitatif. Penelitian ini dilakukan di Madrasah Ibtidaiyah (MI se-kabupaten Tulungagung. Waktu penelitian adalah 4 bulan sejak bulan Mei hingga Agustus 2018. Subyek penelitian yang digunakan sebagai responden dalam kegiatan penelitian norma BITRAGAMI adalah anak) kelas atas dengan usia 10 sampai 12 tahun, siswa dalam penelitian ini adalah siswa MI mulai kelas empat hingga kelas enam yang diambil secara simple random sampling. Tinggi badan pada jenis kelamin laki-laki maupun perempuan pada setiap tingkatan usia mengalami kenaikan secara rata-rata disetiap jenjang. Berat badan serta jenis kelamin laki-laki maupun perempuan pada setiap tingkatan usia mengalami kenaikan secara rata-rata disetiap jenjang, rata-rata berat badan secara keseluruhan adalah 44,3 kg. Kemampuan lempar tangkap bola tenis selalu mengalami kenaikan dengan range data 17,5 kali hingga rata-rata 33,7 kali dalam satu menit. Kemampuan lempar bola basket jenis kelamin laki-laki mulai usia 10-12 tahun secara rata-rata lebih baik dari pada jenis kelamin perempuan dengan rata secara keseluruhan 3,5 meter. Kemampuan lempar tangkap bola tenis. Secara keseluruhan rata-rata kemampuan loncat tegak adalah 24,87 sentimeter. Rata -rata kemampuan lari kelincahan adalah 19,6 detik. Secara keseluruhan rata-rata kemampuan lari multi fitness test adalah 5,52.
|
2022-08-20T09:06:39.441Z
|
132,156,888 |
{
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"DOI": "10.2172/7362323",
"MAG": "2464059253",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "https://digital.library.unt.edu/ark:/67531/metadc1447903/m2/1/high_res_d/7362323.pdf"
}
|
This report contains the basis for oral testimony to the House Committee on Science and Technology's Subcommittee on Environment and the Atmosphere in November 1975. The subject of the hearings was ''Effects and Costs of Long-term Exposure to Low Levels of Manmade Pollutants'' and the purpose of the hearings was to increase the awareness of low-level pollution and its impacts on human health, agriculture and climate. This report contains information related to impacts of low-level pollutants on human health. I have attempted to point out the major adverse health effects (e.g., carcinogenic, mutagenic and teratogenic) that may result from chronic exposure to low-level pollutants. Also addressed are important questions such as what do we know about dose-response relations for chronic exposure to pollutants and how can we establish comparisons with knowledge obtained from exposure to ionizing radiations. The report also considers the wisdom of extrapolating from health effects data obtained from acute, high-level exposures to chronic, low-level exposure conditions. Lastly, a few examples of the societal costs related to low-level pollutant exposure are presented. (auth)
|
2022-08-20T18:57:53.711Z
|
162,259,835 |
{
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"ArXiv": null,
"DOI": "10.1353/HJR.2010.0114",
"MAG": "2076993929",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Only a few words into the story and we know where we are, at least in general— we are in Henry James country, the jungle. In another sense, of course, we are nowhere at all. We do not know who "he" is or who "they" are or what "the speech that startled him" is or why the speech should have startled him at all. A few steps more and we are already in the thick of it, wading through syntax that surges fitfully forward, over and around the interjections and appositions, hacking through dense qualifications and abstract nomináis, swatting at pronouns that buzz about, hovering, always seeming to be but never quite there. We resist an initial impulse to just give up, to return to easier terrain, because deep inside we believe that attacking the wilderness is good for us, and because maybe, just maybe, winded and overwrought, we'U experience that rush of sense and feeling that comes with a prolonged effort, when the words take over and for a glorious period we're somewhere else, inside the words or behind them, wherever words take us.
|
2022-08-27T22:58:23.397Z
|
96,750,677 |
{
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"DOI": "10.1590/S0104-14282001000400006",
"MAG": "2128374429",
"PubMedCentral": null
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"license": null,
"status": null,
"url": null
}
|
Deacetylation reactions of commercial chitin were carried out in aqueous sodium hydroxide solution at 115°C for 6 hours. The effect from additives (sodium borohydride or anthraquinone) and of bubbling inert gas (nitrogen or argon) on the characteristics of deacetylated samples were evaluated. Average degrees of acetylation and intrinsic viscosity were determined by 1H NMR spectroscopy and capillary viscometry, respectively. X-ray diffraction was employed to evaluate changes in crystallinity and infrared spectroscopy was used to monitor structural changes due to deacetylation. The bubbling of inert gas during the deacetylation reaction resulted in more crystalline samples of chitosan. Deacetylations carried out without any additive produced slightly more deacetylated chitosans but they were severely depolymerized. The depolymerization process was much less important when sodium borohydride was added to the reaction medium but the addition of anthraquinone and the bubbling of nitrogen, or argon, did not have any effect, this suggests that oxygen is not required for depolymerization.
|
2022-12-17T10:27:13.823Z
|
129,320,589 |
{
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"ACL": null,
"ArXiv": null,
"DOI": "10.1126/SCIENCE.299.5611.1294A",
"MAG": "2059365602",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
PLANETARY SCIENCEAt a NASA press conference here last week and in a paper published online by Nature on 19 February, a planetary scientist presented new images from Mars that suggest that slow melting of snowfields left from the last martian ice age could have eroded gullies beneath the snow. If so, lingering snow patches might harbor life still.
|
2022-02-09T14:52:36.594Z
|
72,233,422 |
{
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"ACL": null,
"ArXiv": null,
"DOI": "10.1136/BMJ.1.4920.1014",
"MAG": "2025937713",
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},
"license": null,
"status": null,
"url": null
}
|
Atlas of Congenital Cardiac Disease. By Maude E. Abbott, B.A., M.D., F.R.C.P.(Canada). (Pp 62+x; illustrated. $5.) New York: American Heart Association. 1936, reprinted August, 1954. This reprinting of Maude Abbott's well-known monograph will bring great joy to many. When this book was reviewed in these pages on its first appearance in 1936 it was stated that it " must be included among the few modern medical publications destined to become classics." This prediction has proved to be amply justified, for it has been almost impossible to obtain a copy, and many first-class libraries have also been without one. The American Heart Association is to be congratulated, not only on its action in publishing this facsimile, but on the excellence and accuracy of its production. Everyone interested in congenital heart disease from its present manifold aspects will now be able to acquire a copy, and libraries will be able to correct their deficiency. However, those who want the book will have to hurry, as only 1,500 copies have been printed. One would have thought that several times this number will be needed, and we must hope that other impressions will follow. The A tlas is, as is well known, based on a study and analysis of 1,000 cases of congenital heart disease, its statistical analysis being often quoted. It contains an excellent presentation of the development and comparative anatomy of the heart as a basis for the clinical and morbid anatomical presentations, which are profusely and well illustrated, even for to-day with our better radiography and electrocardiography and the revelations of angiocardiography. It is a pity that the author was never able to do what she states in the preface was her intention-namely, to produce a further volume. The book has only one drawback-its large, awkward size, which makes it difficult to handle and very difficult to find shelf room for. It would have been so much better if it had originally been produced only half the size. No change, of course, was possible in this facsimile. RUSSELL BROCK.
|
2022-02-11T10:08:52.404Z
|
25,816,725 |
{
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"ArXiv": null,
"DOI": "10.1097/MD.0000000000008240",
"MAG": "2769032541",
"PubMedCentral": "5704785"
},
"license": null,
"status": null,
"url": null
}
|
Abstract Approximately 40% to 50% of gastrointestinal stromal tumor (GIST) patients will have recurrence or metastases after resection of the primary lesion, and the most common affected sites will be liver and peritoneum. Imatinib has been considered as the first-line therapy of metastatic GIST. Surgery for metastases is proposed when possible. Furthermore, there are controversies concerning hepatic resection and systemic tyrosin kinase inhibitors (TKIs). The therapeutic conditions and long-term outcome of GIST patients with liver metastases in northern China remain unknown. The clinical, pathological, and follow-up data of 144 GIST patients, who had liver metastases between June 1996 and June 2014 from 3 tertiary cancer centers in northern China, were reviewed. Thirty-two cases (22.2%) had hepatectomy with 23 (23/32, 71.9%) R0 resections and 9 (9/32, 28.1%) R1/R2 resections, respectively. Twenty-three patients were given imatinib postoperatively. Furthermore, 98 (68.1%) patients were given TKIs only to control disease progression, and sunitinib was considered after imatinib failure in 12 patients. The 1-, 3- and 5-year survival rate was 82%, 51%, and 24%, with a median overall survival of 48 months for all patients. Patients who had hepatic resection combined with TKIs had a tendency of improved outcome, and the median survival time was 89 months. This was in contrast to patients who received TKIs only, in which median survival time was 53 months. Patients who received imatinib plus sunitinib had a tendency of longer survival time, compared with patients who received imatinib only (not reached vs 50 months). TKIs combined with hepatic resection had a role in improving the outcome of GIST patients with liver metastases.
|
2022-10-10T16:10:22.136Z
|
233,754,853 |
{
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"ArXiv": null,
"DOI": "10.2139/ssrn.3694403",
"MAG": "3127486155",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Abstract Increasing evidence points towards the episodic emergence of pockets with extreme return persistence. This notion refers to intraday periods of non-trivial duration, for which stock returns are highly positively autocorrelated. Such episodes include, but are not limited to, gradual jumps and prolonged bursts in the drift component. In this paper, we develop a family of integrated volatility estimators, labeled differenced-return volatility ( DV ) estimators, which provide robustness to these types of Ito semimartingale violations. Specifically, we show that, by using differences in consecutive high-frequency returns, our DV estimators can reduce the non-trivial bias that all commonly-used estimators exhibit during such periods of apparent short-term intraday return predictability. A Monte Carlo study demonstrates the reliability of the newly developed volatility estimators in finite samples. In our empirical volatility forecasting application to S&P 500 index futures and individual equities, our DV -based Heterogeneous Autoregressive (HAR) model performs well relative to existing procedures according to standard out-of-sample MSE and QLIKE criteria.
|
2022-11-20T15:59:00.220Z
|
25,437,745 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2169/internalmedicine.0023-17",
"MAG": "2801932133",
"PubMedCentral": "6191605"
},
"license": null,
"status": "GOLD",
"url": "https://www.jstage.jst.go.jp/article/internalmedicine/57/18/57_0023-17/_pdf"
}
|
A 33-year-old man was admitted to our hospital to undergo an evaluation to determine the cause of secondary hypertension. Computerized tomography angiography (CTA) showed bilateral multiple renal arteries with significant stenosis of the right extra-renal artery due to fibromuscular dysplasia and segmental impairment of renal perfusion. Although the plasma aldosterone concentration and plasma renin activity were within the normal ranges, percutaneous balloon dilatation of the stenotic lesion resolved his hypertension, leading to a diagnosis of renovascular hypertension caused by segmental renal ischemia due to extra-renal artery stenosis. CTA should be considered during the examination of patients with early-age hypertension, even if the plasma renin activity is not sufficiently elevated.
|
2022-12-03T14:27:22.941Z
|
121,155,668 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1088/0256-307X/21/11/006",
"MAG": "2029483955",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
We study the transport of spin-polarized current induced by the Aharonov–Bohm and Aharonov–Casher phases in a mesoscopic ring with two leads in the presence of a cylindrically symmetric electric field and the magnetic flux at the centre of the same ring. An exact solution for the quantum transport is obtained. It is shown that the transport spin-polarized current and its polarizability can be controlled by the electric field and the magnetic flux as well.
|
2022-12-11T06:58:51.774Z
|
35,843,333 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1021/BI952923Q",
"MAG": "2081200472",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
We have expressed catalytically active Toxoplasma gondii dihydrofolate-thymidylate synthase (DHFR-TS) and the individual TS and DHFR domains in Escherichia coli using the T7 promoter of pET-15b. DHFR-TS constituted approximately 10% of the total soluble cell protein and was purified using methotrexate-Sepharose chromatography to yield 10 mg of homogeneous DHFR-TS per liter of culture. The DHFR domain was recovered as insoluble inclusion bodies which could be unfolded and refolded to recover soluble, active enzyme. The TS domain was overexpressed as a soluble protein by growing the cells at 24 degrees C; this is the first report of the expression of an active TS domain from a bifunctional enzyme. The kcat and K(m) values for DHFR-TS are similar to those of other previously characterized protozoan DHFRs and TSs. The antimicrobial antifolates, TMP and Pyr, inhibit DHFR activity of the bifunctional protein in accord with their effects in crude enzyme preparations and in vivo systems. Kinetic parameters and Ki values for TMP and Pyr with the isolated DHFR domain were identical to the values for DHFR in the bifunctional enzyme. Evidence of kinetic channeling of the dihydrofolate product of TS to the DHFR domain in the bifunctional enzyme was obtained by kinetic and inhibition studies. Properties such as yield, stability, and activities of the recombinant T. gondii DHFR-TS provide clear advantages over other bifunctional DHFR-TSs as a model for future studies.
|
2022-12-20T15:48:46.535Z
|
218,800,464 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.1096/fasebj.2020.34.s1.02793",
"MAG": "3017221691",
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"license": null,
"status": null,
"url": null
}
|
Dissection can reveal or obscure aspects in our understanding of the human body. Destroying one part of the connected form in order to reveal a particular perception of the body system is, by nature, part of dissection technique. However, our understanding of the body has continued to change based on techniques from fresh tissue to shellacked, embalmed, semi‐fixed, plastinated and more. This raises the question of how much of our perception of the human body at any one point is based on technique and approach or our desire to see and name in a defined manner. Does one influence the other? Anatomists during the Renaissance, for example, worked with fresh tissue, and artists portrayed the musculoskeletal system, as well as the importance of connection and fascia in their movement‐filled illustrations. Modern techniques from decellurization to plastination have created newer fascial models, reversing the thought process of figure/ground perception of our previously muscle‐focused atlases. For example, the interstitium was recently named a new organ, based on fresh tissue samples that allowed the ability to see 3D fluid‐filled spaces in what was previously flattened in preserved tissue. While anatomy remains a key component of medical school training, it is widely documented that time spent in a physical dissection lab is decreasing. With less time in lab, are key components of three‐dimensional learning being lost, or simply not “seen” based on preserved tissue cadavers? Three‐dimensional computer models are stunning in the process to bring learning to areas that have low access to donation programs, but the computer scans are still based on a limited number of forms and may choose to obliterate certain tissues. Additionally, the loss of touch and fine motor skill that is practiced in cadaver lab is difficult to reproduce in a virtual model. Through a survey of anatomical illustrations, engravings, drawings and photography, it is evident that this raises questions on our past anatomical history to the importance of how our anatomy models of the future (from virtual reality to synthetic cadavers) may once again influence how we perceive the body, particularly in relationship to fascia.
|
2022-06-18T14:40:16.782Z
|
221,047,523 |
{
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"DOI": "10.1177/107769908906600114",
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"status": null,
"url": null
}
|
,Hispanic Americans are one of this country's fastest-growing minority groups, expected to become the largest minority by the year 2000. For that reason, one might expect a great deal of attention would be paid to Hispanic Americans by society at large and by the news media, which serve as society's window on the world. This study sought to examine that expectation by studying the relative and comparative extent to which two particular windows on the world-two daily newspapers-focused their editorial attention on Hispanic Americans, who already are the largest minority group in the markets represented by these newspapers.' Hispanic Americans have complained that newspaper coverage of Hispanics or Hispanic issues is biased, usually because
|
2022-09-03T07:24:15.575Z
|
62,020,022 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/VETECF.1999.797335",
"MAG": "2141479780",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This paper proposes a joint road-to-vehicle and vehicle-to-vehicle communications system with non-regenerative repeater. In the proposed system, each vehicle has a non-regenerative repeater function to relay the received signals to the other vehicles. In the proposed system, since the received signal at one vehicle receiver is re-transmitted without regenerative detection, the inter-vehicle communication network can easily be achieved without complex dynamic routing functions, also the proposed system can effectively overcome the shadowing problem. This paper analyzes the transmission performance of the proposed system with pure-ALOHA, and DS-CDMA (direct sequence-code division multiple access) protocols, and shows that the proposed system is effective.
|
2022-09-14T23:50:11.025Z
|
221,729,073 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/j.1528-1167.2006.00678.x",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
The assessment of cognitive functions is part of any neurological examination but the development of increasingly sophisticated testing procedures has led to the gradual identification of neuropsychology as a specific discipline, and the neuropsychological profiles associated with different brain lesions have now been characterized along the lines of the anatomo-functional correlations first revealed by Broca’s seminal observation. This approach has greatly benefited from the advent of functional imaging techniques, which have allowed neuropsychological investigations, especially of partial epilepsies, particularly in centers specializing in epilepsy surgery, where the careful drawing up of a patient’s cognitive profile was considered essential for defining a surgical strategy aimed at avoiding, or at least minimizing, the risk of unacceptable cognitive dysfunction. The value of the neuropsychological approach to epilepsies in general has become gradually clearer since the emergence of the concept of epilepsy syndromes. According to the definition of the International League Against Epilepsy (ILAE) “epilepsy is a chronic condition of the brain characterized by an enduring propensity to generate epileptic seizures, and by the neurobiological, cognitive, psychological, and social consequences of this condition.” An epileptic syndrome (i.e., a complex of signs and symptoms defining a unique epilepsy condition) is therefore not only characterized by the types of seizure and their natural history, but also by its peculiar cognitive profile. As ILAE President, I particularly appreciated the idea of a group of experienced epileptologists to involve the ILAE Commission of Psychobiology in the organization of a meeting devoted to the cognitive and behavioral outcomes of epileptic syndromes, and it is the contributions presented at this meeting (held in Bologna in October 2004) that form the basis of the papers included in this Epilepsia supplement. These papers comprehensively cover the entire subject. The first section deals with general aspects, methodologies, and the effects of antiepileptic drugs on cognition, behavior, and mood. This is followed by four sections describing the different epileptic syndromes under the headings of epileptic encephalopathies, idiopathic focal epilepsies, cryptogenic and symptomatic focal epilepsies, and idiopathic generalized epilepsies.
|
2022-10-21T00:17:03.083Z
|
5,441,755 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1053/j.gastro.2008.02.031",
"MAG": "2152858484",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
BACKGROUND & AIMS
Contraction of the longitudinal muscle of the esophagus may play a role in the relaxation and opening of the lower esophageal sphincter (LES). The goal of our study was to determine the pattern and precise temporal correlation between local longitudinal muscle contraction (LMC) of the esophagus during peristalsis and transient LES relaxation (TLESR).
METHODS
Esophageal pressures and high-frequency intraluminal ultrasound imaging of the esophagus were recorded in 24 healthy subjects during swallow-induced peristalsis and spontaneous TLESR. Intraluminal multiple impedance recordings were obtained to determine the relationship between "common cavity pressure" and gastroesophageal reflux (GER).
RESULTS
During swallow-induced peristalsis, there is simultaneous contraction of circular and longitudinal muscles of the esophagus. On the other hand, TLESR is associated with a distinct pattern of LMC in the esophagus that has the following characteristics: (1) it is restricted to the distal esophagus; (2) it begins before the onset of TLESR and spreads in a retrograde manner; (3) it is generally stronger than the swallow-induced contraction; and (4) it is sustained during the entire duration of TLESR. The increase in esophageal pressure during TLESR is temporally correlated with the contraction of the LM of the distal esophagus, rather than with the impedance recorded GER.
CONCLUSIONS
We propose that the LMC of the distal esophagus may play an important role in the relaxation of LES and induction of GER.
|
2022-12-16T00:23:30.729Z
|
144,643,745 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.1080/1090102040240406",
"MAG": "2048919687",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Abstract The Early Childhood Education and Care (ECEC) professional development movement, community college students’ emerging intentionality, and the role of two‐ and four‐year higher education faculty intersect in a proactive model proposed by the author that advocates ECEC community college programs separate from the vocational tradition and establishes ECEC transfer degrees to four‐year programs. Degree structures must be built with flexibility, and encompass checkpoints and highly articulated options as student intentionality unfolds. The proactive model is constructed from Morgan's (1994) 21 st century model of professionalism and her conception of students’ emerging intentionality, combined with Brint and Karabel's (1989) models that attempt to explain why community colleges moved from conferring primarily transfer degrees to conferring primarily vocational degrees.
|
2022-12-12T17:37:42.023Z
|
5,194,562 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/j.1747-0285.2009.00909.x",
"MAG": "1989930530",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A series of 1‐azolyl‐4‐phenyl‐2‐butanones was designed and synthesized for the inhibition of heme oxygenases (heme oxygenase‐1 and heme oxygenase‐2). The replacement of imidazole by other azoles led to the discovery of novel 1H‐1,2,4‐triazole‐ and 1H‐tetrazole‐based inhibitors equipotent to a lead imidazole‐based inhibitor. The inhibitors featuring 2H‐tetrazole or 1H‐1,2,3‐triazole as the pharmacophore were less potent. Monosubstitution at position 2 or 4(5), or identical disubstitution at positions 4 and 5 of imidazole by a variety of electron‐withdrawing or electron‐donating, small or bulky groups, as well as the replacement of the traditional imidazole pharmacophore by an array of 3‐ or 5‐substituted triazoles, identically 3,5‐disubstituted triazoles, 5‐substituted‐1H‐ and 5‐substituted‐2H‐tetrazoles proved to be detrimental to the inhibition of HO, with a few exceptions. The azole‐dioxolanes and the azole‐alcohols derived from the active azole‐ketones were synthesized also, but these inhibitors were less active than the corresponding imidazole‐based analogs. The first reported X‐ray crystal structure of human heme oxygenase‐1 in complex with a 1,2,4‐triazole‐based inhibitor, namely 4‐phenyl‐1‐(1H‐1,2,4‐triazol‐1‐yl)‐2‐butanone, was also determined. The inhibitor binds to the human heme oxygenase‐1 distal pocket through the coordination of heme iron by the N 4 in the triazole moiety, whereas the phenyl group is stabilized by hydrophobic interactions from residues within the binding pocket.
|
2022-12-19T01:14:31.163Z
|
216,084,808 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1089/tmj.2020.0106",
"MAG": "3018398053",
"PubMedCentral": "7415870"
},
"license": "CCBYNC",
"status": "HYBRID",
"url": "https://doi.org/10.1089/tmj.2020.0106"
}
|
In the time of COVID-19 epidemic, Italy was found unprepared to manage lockdown patients with chronic diseases, due to limited availability and diffusion of large-scale telemedicine solutions. The scattered distribution and heterogeneity of available tools, the lack of integration with the electronic health record of the national health system, the poor interconnection between telemedicine services operating at different levels, the lack of a real multidisciplinary approach to the patient's management, the heavy privacy regulations, and lack of clear guidelines, together with the lack of reimbursement, all hinder the implementation of effective telemedicine solutions for long-term patients' management. This COVID-19 epidemic should help promote better use and a larger integration of telemedicine services in the armamentarium of health care services. Telemedicine must no longer be considered as an option or add-on to react to an emergency.
|
2022-12-27T23:02:10.995Z
|
239,396,995 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.1175/jas-d-21-0047.1",
"MAG": null,
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},
"license": null,
"status": "BRONZE",
"url": "https://journals.ametsoc.org/downloadpdf/journals/atsc/78/11/JAS-D-21-0047.1.pdf"
}
|
Prominent cirrus cloud banding occurred episodically within a northern cirrus canopy of Typhoon Talim (2017) during its recurvature. The generation mechanisms of the cirrus bands and low static-stability layers that support the bands are investigated using a numerical simulation with the Advanced Research Weather Research and Forecasting Model. Inspection of model output reveals that thin layers of near-neutral to weakly unstable static stability are persistently present in the upper and lower parts of the upper-level outflow, and shallow convection aligned along the vertical shear vector is prevalent in these layers. The cirrus banding occurs as the lowered outflow from the weakening storm ascends slantwise over a midlatitude baroclinic zone, and updrafts of the preexisting shallow convection in the upper part of the outflow layer become saturated. It is shown that the strong outflow resulting from violation of gradient-wind balance in the core region, by itself, creates the low static-stability layers. Analyses of potential temperature and static stability budgets show that the low static-stability layers are created mainly by the differential radial advection of radial thermal gradients on the vertical edges of the outflow. The radial thermal gradients occur in response to the outward air parcel acceleration in the core region and deceleration in the outer region, which, by inducing compensating vertical mass transport into and out of the outflow, act to tilt the isentropes within the shear layers. The effects of environmental flow and cloud radiative forcing on the cirrus banding are also addressed.
|
2022-01-24T18:44:16.502Z
|
171,323,332 |
{
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"ArXiv": null,
"DOI": "10.22456/1679-1916.67344",
"MAG": "2527620329",
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},
"license": null,
"status": "BRONZE",
"url": "https://seer.ufrgs.br/renote/article/download/67344/38435"
}
|
Este trabalho apresentou o estudo de um caso de aplicacao da tecnica de avaliacao em pares como mecanismo de avaliacao em um curso de especializacao a distância. O estudo foi realizado por meio do preenchimento de um questionario pelos alunos e tambem pela analise de dados do proprio curso estudado. A maioria dos alunos considerou a avaliacao realizada pelos colegas como justa ou muito justa e que ela contribui com seu aprendizado. Entretanto, este trabalho identificou indicios que uma parte consideravel dos alunos nao se dedicou completamente a avaliacao. O trabalho ainda apresenta licoes aprendidas da execucao deste processo.
|
2022-02-08T16:53:27.776Z
|
78,179,448 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3760/CMA.J.ISSN.1000-6672.2015.10.006",
"MAG": "2563272495",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Objective
To analyze the policy support of rural doctors for the essential medicine system, and explore the main influence factors and mechanism affecting the support degree.
Methods
621 rural doctors from five cities in Shandong province were subject to a stratified random sampling for a quantitative questionnaire, to build a hypothesis model of policy support of rural doctors, which is verified using factor analysis and path analysis.
Results
59.1% of rural doctors support the essential drugs policy.It was found that the essential medicine factor, the factor to influence the practitioner, and the supporting policy factor had a direct impact on policy support of rural doctors, with the effect of 0.305, 0.159 and 0.135 respectively; Essential medicine factor and the supporting policy factor indirectly influence the policy support of rural doctors through the factor to influence practitioners, with the effect of 0.065 and 0.032 respectively.
Conclusion
The essential medicine system needs to emphasize such rationality as the quality, list and pricing of essential medicines; it is imperative for the government to better oversee the purchase and supply of essential drugs, to cater to the interests of rural doctors, to encourage the enforcement of the system, and promote the development of village clinics.
Key words:
Rural doctors; Essential medicine; Support of policy; Influence
|
2022-02-11T05:00:06.044Z
|
238,372,405 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.21697/SEB.2007.5.1.36",
"MAG": "3125469581",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Polska jest krajem o stosunkowo młodej gospodarce wolnorynkowej. Przez szereg lat uczyliśmy się reguł jakimi rządzi się ten model gospodarczy. Był to czas w którym należało nadrobić zaległości wynikające z utopijnego charakteru syste mu społeczno-gospodarczego w jakim Polska tkwiła przez blisko pół wieku. Gospodarka wolnorynkowa wykorzystuje szereg narzędzi kształtujących popyt i podaż produktów, jednym z nich jest promocja. Obecnie trudno by wymienić dziedzinę gospodarki w której działania promocyjne są zbędne. Promocja „(...) obejmuje zespół działań i środków za pomocą których przedsiębiorstwo przeka zuje na rynek informacje charakteryzujące produkt i/lub firmę, kształtuje potrzeby nabywców oraz pobudza, ukierunkowuje i zmniejsza elastyczność popytu”1. Promocja jest wykorzystywana nie tylko przez przemysł ciężki, ale również przez także bardzo dochodową turystykę. Szczególnie aktywne działanie w tej sferze mają lub powinny mieć miejsce w regionach dla których turystyka jest jedyną szansą na rozwój. Jednym z takich regionów w Polsce jest region gminy i miasta Bartoszyce.
|
2022-05-30T08:45:23.335Z
|
78,616,114 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1158/1538-7445.AM2016-4520",
"MAG": "2479979756",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Enhancer of Zeste Homolog 2 (EZH2) is a catalytic core subunit of the Polycomb repressive complex 2, PRC2. EZH2 catalyzes the tri-methylation of lysine 27 on histone H3 (H3K27me3) which often results in the silencing of associated gene promoters. The over-expression of EZH2 is associated with cancer progression and poor prognosis in solid tumors and hematological malignances. EZH2 mutations in lymphoma generally are activating whereas those in myelodysplasia and acute myeloid leukemia are typically loss of function. Additionally, EZH2 mutations are not isolated to a hotspot and therefore discerning phenotype is challenging. The purpose of this study was to determine if the inhibition of EZH2 induces cell differentiation or apoptosis in AML, and to determine the significance of EZH2 mutations in AML patients. As H3K27me3 deposition is catalyzed by EZH2, we hypothesized that analysis of H3K27me3 levels could differentiate an inactivating EZH2 mutation. We analyzed H3K27me3 levels in AML patient samples with wild type (N = 5) and mutant (N = 3) EZH2, and found that overall H3K27me3 is reduced in the mutant patient samples. Furthermore, the sample with the highest variant allele frequency (VAF) of the EZH2 mutation had noticeably lower levels of H3K27me3 compared to those that had a lower VAF. This finding demonstrates that diminished H3K27me3 levels can predict the presence of an inactivating EZH2 mutation in AML cells. We next assessed if the EZH2 tool molecule EPZ011989 produced a similar phenotype in wild-type EZH2 AML cell lines (Kasumi-1, MOLM-13, and MV4-11). EPZ011989 inhibited H3K27me3 in all of the cell lines at a concentration of 0.625 μM after only four days of treatment. At these concentrations and this time point we demonstrated no change in viability among these three cell lines and only minimal proliferation inhibition in MV4-11 and MOLM-13 cells. Longer time points are currently being investigated as EZH2 inhibitors often induce anti-proliferative effects only after longer incubation periods. Therefore, our results support that inactivation of EZH2 with EZP011989 in AML cell lines induces the same cell-biochemical consequence (i.e. H3K27me3 loss) associated with EZH2 mutations in AML patients. This potentially will allow diverse pharmacologic studies in cell lines relative to gene targets and also synergistic lethality studies utilizing genetic and pharmacologic screening techniques to potentially develop therapeutic agents to treat this subtype of AML. Citation Format: Sydney Fobare, Cecelia Miller, Shelley J. Orwick, Heike Keilhack, Erin Hertlein, John C. Byrd. The effect of EPZ011989, an enhancer of Zeste homolog 2 inhibitor, in acute myeloid leukemia. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 4520.
|
2022-02-11T04:37:03.920Z
|
72,943,376 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4172/2332-0877.1000123",
"MAG": "2101256256",
"PubMedCentral": null
},
"license": "CCBY",
"status": "HYBRID",
"url": "https://doi.org/10.4172/2332-0877.1000123"
}
|
In June 2012, a previously unknown human coronavirus was isolated from a 60 year-old Saudi-Arabian patient who died from acute respiratory distress syndrome and multiple organ failure [1]. Subsequently, the novel virus was detected from several additional residents and visitors of the Arabian Peninsula countries including Saudi Arabia, Jordan, Qatar, and the United Arab Emirates (UAE). This virus is currently called Middle East Respiratory Syndrome virus (MERS-CoV). It is the first virus belonging to betacoronavirus lineage C that has been associated with human disease. Globally, from September 2012 to date, WHO has been informed of a total of 157 laboratoryconfirmed cases of infection with MERS-CoV, including 66 deaths [2]. It is recommended for physicians to be vigilant toward testing for MERS-CoV. Other potential causes of respiratory infections should be ruled out using routinely available laboratory tests. Lower respiratory tract samples such as bronchoalveolar lavage are recommended better than upper respiratory tract samples to test for MERS-CoV. A number of RT-PCR assays that are specific for the novel coronavirus have been developed. These include an assay targeting upstream the E protein gene (upE), an assay targeting the open reading frame 1b (ORF 1b) gene and an assay targeting the open reading frame 1a (ORF 1a) gene [3]. The assay for the upE target is considered highly sensitive, with the ORF 1a assay believed to be of equal sensitivity. The ORF 1b assay is considered less sensitive than the ORF 1a assay but may be more specific [3]. By November of 2012, the virus had already been discovered in multiple countries in the Arabian peninsula including Qatar, Jordan and Saudia Arabia .In that time it was also feared that the virus also circulated in Kuwait. The situation was made worse by the arrival of the Hajj season when several thousands of KUWAITI people traveled to Saudi Arabia in the presence of the virus which behavior was unknown. Therefore, MERS-CoV PCR was established targeting ORF-1b in the virology unit in Mubarak Alkabeer Hospital Faculty of Medicine, Kuwait in December of 2012 to screen for the presence of the virus in the country as a cause of severe respiratory tract infection and to detect any imported cases. On November, 2013 another method was replaced to test for MERS-CoV after screening with upE is ModularDx Kit corona Orf1a by TIB and the previous method is now used as secondary test. Almost one year after the identification of the new virus we would like to report our experience.
|
2022-08-27T06:05:43.254Z
|
22,197,966 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/1440-1681.12598",
"MAG": "2404916197",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "http://eprints.keele.ac.uk/1824/1/R%20Chen%20-%20Effects%20of%20transthyretin%20on%20thyroxine%20and%20B-amyloid%20removal%20from%20cerebrospinal%20fluid%20in%20mice.pdf"
}
|
Transthyretin (TTR) is a binding protein for the thyroid hormone thyroxine (T4), retinol and β‐amyloid peptide. TTR aids the transfer of T4 from the blood to the cerebrospinal fluid (CSF), but also prevents T4 loss from the blood‐CSF barrier. It is, however, unclear whether TTR affects the clearance of β‐amyloid from the CSF. This study aimed to investigate roles of TTR in β‐amyloid and T4 efflux from the CSF. Eight‐week‐old 129sv male mice were anaesthetized and their lateral ventricles were cannulated. Mice were infused with artificial CSF containing 125I‐T4/3H‐mannitol, or 125I‐Aβ40/3H‐inulin, in the presence or absence of TTR. Mice were decapitated at 2, 4, 8, 16, 24 minutes after injection. The whole brain was then removed and divided into different regions. The radioactivities in the brain were determined by liquid scintillation counting. At baseline, the net uptake of 125I‐T4 into the brain was significantly higher than that of 125I‐Aβ40, and the half time for efflux was shorter (125I‐T4, 5.16; 3H‐mannitol, 7.44; 125I‐Aβ40, 8.34; 3H‐inulin, 10.78 minutes). The presence of TTR increased the half time for efflux of 125I‐T4 efflux, and caused a noticeable increase in the uptake of 125I‐T4 and 125I‐Aβ40 in the choroid plexus, whilst uptakes of 3H‐mannitol and 3H‐inulin remained similar to control experiments. This study indicates that thyroxine and amyloid peptide effuse from the CSF using different transporters. TTR binds to thyroxine and amyloid peptide to prevent the loss of thyroxine from the brain and redistribute amyloid peptide to the choroid plexus.
|
2022-09-11T03:43:15.540Z
|
22,995,574 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1046/j.1365-2141.1998.01031.x",
"MAG": "2072344463",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://onlinelibrary.wiley.com/doi/pdfdirect/10.1046/j.1365-2141.1998.01031.x"
}
|
CD40 ligand (CD40L) is involved in the T‐cell‐dependent regulation of B‐cell growth and survival and can rescue normal germinal centre B cells and several types of malignant B cells from apoptosis in vitro. We have previously reported that serum of patients with chronic lymphocytic leukaemia contained elevated levels of biologically active soluble CD40L (sCD40L). Whether an augmented CD40L pathway exists in patients with other types of B‐cell lymphoid malignancies and the source of native sCD40L in these patients is currently unknown. Using a sensitive ELISA assay, soluble CD40L (sCD40L) was detected in the sera of both healthy individuals and patients with haematological malignancies; however, its level was significantly elevated only in patients with B‐cell lymphomas (P < 0.0001). Several types of malignant B cells coexpressed CD40 and CD40L proteins, and CD40L mRNA was detected in purified resting malignant B cells. The dual expression of CD40 and CD40L in B cells and the presence of native sCD40L in human serum suggest that a direct T–B‐cell contact may not be required for CD40L delivery to B cells. This data raises the possibility that an autocrine cytokine loop involving CD40L may contribute to the growth regulation of benign and malignant B cells in vivo.
|
2022-12-18T00:08:56.418Z
|
13,125,991 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/ijc.21941",
"MAG": "2117181727",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.21941"
}
|
International comparisons of interval cancers (IC) are important to better understand the relationship between programmes' performance and screening practices. In this respect, differences in (i) definition, (ii) identification and (iii) quantification of IC have received little attention. To examine these 3 comparability issues and activities involving IC, an assessment was conducted among member countries of the International Breast Cancer Screening Network, and the impact of accuracy of identification and quantification practices was estimated using 1996–98 data from the Dutch breast cancer screening programme. Information was obtained from 19 screening programmes in 18 countries, 16 of which acknowledged the coexistence of opportunistic screening. IC data were collected to evaluate performance of the screening programme (100% of programmes) and the radiologists (89%); 53% of programmes had a designated review process for IC. Most programmes (84%) agreed with the European Guidelines definition of IC, but a case situation exercise evidenced substantial discrepancy in classification of cancers that occurred after a positive screen. Completeness of identification of IC appears to contribute most to international variation, and cannot be easily controlled for in methodologically rigorous comparisons. Statistically significant differences of about 4% were measured between quantification methods for IC. An operational definition of IC is proposed to enhance international comparability. Valid comparisons of IC are possible with careful attention to the definition but true differences in IC frequency across screening programmes should exceed 10% to be possibly indicative of real differences between programmes. © 2006 Wiley‐Liss, Inc.
|
2022-12-19T05:31:13.815Z
|
157,587,350 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1037/e624962007-001",
"MAG": "2595240312",
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
This report begins with an overview of maltreatment, which briefly describes existing national models of prevention, and is followed by the results of the nomination process for effective and innovative child maltreatment prevention programs. The report concludes with a discussion of the limits of existing knowledge about the effectiveness of prevention, the need to expand efforts to understand the performance and impact of prevention programs, and observations about this process and recommendations for next steps.
|
2022-12-17T13:52:55.693Z
|
2,213,954 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/jdi.12242",
"MAG": "2008323317",
"PubMedCentral": "4296708"
},
"license": "CCBYNCND",
"status": "GOLD",
"url": "https://doi.org/10.1111/jdi.12242"
}
|
Measurements of plaque echogenicity, the gray‐scale median (GSM), were shown to correlate inversely with risk factors for cerebro‐cardiovascular disease (CVD). The eicosapentaenoic acid (EPA)/arachidonic acid (AA) ratio is a potential predictor of CVD risk. In the present study, we assessed the usefulness of carotid plaque GSM values and EPA/AA ratios in atherosclerotic diabetics.
|
2022-12-21T15:34:32.934Z
|
251,123,332 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.26760/rekaelkomika.v3i1.38-45",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBYSA",
"status": "GOLD",
"url": "https://ejurnal.itenas.ac.id/index.php/rekaelkomika_pkm/article/download/6026/2782"
}
|
he purpose of this community service activity is to provide training to young farmer groups in Cicarulang village on the use of social media such as Instagram, Whatsapp and Facebook as a means to better market agricultural products, so that they get the best selling price, and to expand their agricultural product market. The method used in this service activity was online training and workshops which were done in two stages. This training was held collaborativelly by Cicarulang young farmer groups and Indraprasta PGRI University. The result of the activity is the improvement of participants’ ability in how to create good and attractive social media accounts, to manage business-based social media accounts as well as to create good marketing content such as making photos and interesting sentences to advertise their products.
|
2022-07-30T10:28:07.157Z
|
7,274,929 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/I2MTC.2015.7151235",
"MAG": "1534482363",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This paper presents a fast algorithm to segment moving objects in video sequences, as the first step of a fast object tracking system. It is based on the detection of level lines to detect closed objects contours in a scene. The detected objects are clustered using a combination of mean shift and ensemble clustering. The proposed method produces a temporal video segmentation in a fraction of the processing time required by comparable state-of-the-art particle-based methods.
|
2022-09-10T12:17:53.780Z
|
252,299,610 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.55936/mauizhah.v11i2.69",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "http://ojs.stit-syekhburhanuddin.ac.id/index.php/mauizhah/article/download/69/66"
}
|
Reward dan Punishment merupakan salah satu prinsippendidikan yang fundamental dalam agama islam. Prinsip –prinsip pemberian reward dan Punishment diantaranya adalahimbalan berfungsi sebagai pengarah dan peneguh responpositif dan prilaku yang benar. Sedangkan hukuman atausanksi adalah untuk melemahkan atau menghilangkan responatau prilaku tertentu anak yang dipandang menyimpang.Imbalan dan hukuman bukanlah tujuan, keduanya adalahsarana untuk mengukuhkan dan menghilangkan perilakutertentu. Teknik pemberian reward dan punishment harus disesuaikan dengan kondisi peserta didik. Punishment bertujuansebagai pencegahan suatu kelalaian dari peserta didik, makareward di berikan sebagai motivasi dan juga penghargaanyang di berikan kepada peserta didik. kedua -duanya bertujuanuntuk memperbaiki peserta didik dalam proses belajarmengajar.
|
2022-09-17T16:41:22.406Z
|
20,273,529 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1074/jbc.M801014200",
"MAG": "2017992719",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The U2 auxiliary factor (U2AF) is an integral part of the spliceosome that is important for the recognition of the 3′ splice site. U2AF consists of a large and a small subunit, the prototypes of which are U2AF65 and U2AF35. Recent evidence suggests that several homologs of both U2AF subunits exist that are able to regulate alternative splicing. Here we have investigated the expression, intracellular localization, and nucleo-cytoplasmic shuttling of one homolog of the small U2AF subunit, U2AF26, and a splice variant lacking exon 7, U2AF26ΔE7. In contrast to the nuclear U2AF26, which displays active nucleo-cytoplasmic shuttling, U2AF26ΔE7 is localized in the cytoplasm. Our studies reveal a nuclear localization sequence in the C-terminal exons 7 and 8 of U2AF26 that differs from the known nuclear localization sequence in U2AF35. In addition, we could identify P32 as a protein that is able to interact with U2AF26 through this domain, and we demonstrate that this interaction is required for the nuclear translocation of U2AF26. Our results suggest the existence of two distinct nuclear import pathways for U2AF26 and U2AF35 that could independently control their intracellular distribution and availability to the splicing machinery. Such a mechanism could work in addition to the differential expression of U2AF homologs to contribute to the regulation of alternative splicing.
|
2022-12-13T05:07:14.577Z
|
86,199,505 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/J.0906-7590.2004.03844.X",
"MAG": "2166559421",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
349.Species distribution patterns have been explained by Hutchinson’s niche theory,metapopulation theory and source-sink theory. Empirical verification of thisframework, however, remains surprisingly scant. In this paper, we test the hypothesisthat landscape characteristics (patch size and connectivity), aerial dispersal ability andniche breadth interact in explaining distribution patterns of 29 spider species inhabitingfragmented grey dunes. Distribution patterns only depended on aerial dispersalpotential, and the interaction between patch connectivity and area. Niche breadth,measured as the degree of habitat specialisation in the total coastal dune system, didnot contribute to the observed distribution patterns. Additional variation in patchoccupancy frequency was strongly species-dependent and was determined by differentresponses to the degree of patch connectivity for ballooning dispersal. Results from thisstudy suggest that dispersal ability largely affects our perception of a species‘‘fundamental niche’’, and that source-sink and metapopulation dynamics may havea major impact on the distribution of species. From a conservation point of view,specialised (and hence intrinsically rare) species can be predicted to become rarer iffragmentation increases and connectivity decreases. This study is, to our knowledge,one of the few linking species distribution (and not patch occupancy, species diversityor richness) to landscape ecological (patch connectivity and area) and auto-ecological(niche breadth, dispersal potential) features.D. Bonte (dries.bonte@ugent.be), L. Lens and J.-P. Maelfait, Terrestrial Ecology Unit,Dept of Biology, Univ. of Ghent, K. L. Ledeganckstraat 35, B-9000 Ghent, Belgium.
|
2022-12-15T06:37:02.345Z
|
246,866,701 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/19336896.2022.2035479",
"MAG": null,
"PubMedCentral": "8855849"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://doi.org/10.1080/19336896.2022.2035479"
}
|
ABSTRACT Creutzfeldt-Jakob disease (CJD) is usually sporadic, but 10–15% of cases are caused by autosomal-dominant pathogenic variants in the prion protein gene (PRNP). A few PRNP variants show low penetrance. We report the case of a 64-year-old man, admitted to the ward with acute onset of aphasia; death occurred 6 weeks later. Brain MRI, EEG pattern and brain pathology were consistent with CJD diagnosis. Genetic analysis revealed a heterozygous V203I variant. We summarized the key clinical findings in patients carrying the V203I variant who were described to date. We also discuss the hypothesis as to whether V203I is a risk factor for CJD rather than a Mendelian disease-associated variant, as well as the possible implications of such hypothesis in the clinical scenario.
|
2022-12-30T00:12:21.419Z
|
101,092,924 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1051/JP4:20020443",
"MAG": "2249923903",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Magnetoresistance and Hall resistance measurements have been carried out in the FISDW phase of deuterated (TMTSF) 2 ClO 4 for various cooling rates through the anion ordering temperature. The Hall resistance in the intermediate cooled state, observed a very stable quantum Hall state above 9.0 T for slowly cooled, shows a step-like change from the phase between 10 and 17 T to the phase between 20 and 25 T with hysteresis between 14 and 21 T. This result suggests that there is a new phase transition around 15 T in deuterated (TMTSF) 2 ClO 4 . A possible ground state of the FISDW phase of (TMTSF) 2 ClO 4 for various cooling rates is discussed from the viewpoint of the peculiar SDW nesting vector stabilized by the dimerized gap due to anion ordering.
|
2022-02-10T10:44:57.207Z
|
28,657,614 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/68.853540",
"MAG": "2096890094",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
We studied the impact of coherent crosstalk on system performance in optical add-drop multiplexers (OADM's) in both aligned and misaligned bit pattern cases. The concept of fading penalty is introduced to evaluate the impact. The results indicate that bit pattern misalignment will reduce the impact of coherent crosstalk when the crosstalk level is low and the number of crosstalk paths is large, but will increase it when these conditions are not satisfied.
|
2022-02-12T14:10:49.105Z
|
183,386,848 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.32112/2174.2464.10.18",
"MAG": "2337377061",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
El articulo presenta un analisis de la picaresca, entendida como mito literario y fenomeno social, en El ministerio del tiempo. El estudio se enfoca en el capitulo sexto, “Tiempo de picaros”. El empleo ambivalente de la picaresca en la serie permite reflexionar en torno a la identidad espanola y sus valores, asunto polemico y de especial relevancia en tiempos de crisis.
|
2022-06-04T11:13:10.099Z
|
17,986,555 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/ICIAS.2014.6869457",
"MAG": "2006462489",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Visual surveillance system for tracking crowd using multiple cameras at dynamic backgrounds faces many challenges such as illumination variance, occultation, low spatial temporal resolution, sleeping person, shadows and camera noise. In this paper we address the issue of gradual and sudden illumination variance caused by movement of the sun and the clouds. We evaluate Mixture of Gaussian method and background modelling method for extracting foreground from the background for crowd related data base. We have evaluated the performance of the background model for sparse and dense crowds to evaluate the accuracy and efficiency of the model subjectively for crowd analytics based scenarios.
|
2022-09-01T08:13:58.251Z
|
98,722,224 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1246/BCSJ.62.1745",
"MAG": "2087026326",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Tracer diffusion coefficients for the [Fe(phen)3]2+ cation (phen=1,10-phenanthroline) have been measured in aqueous solutions of sodium 1-hexane-, 1-octane-, 1-decane-, and 1-dodecanesulfonate (NaDSO) in concentration ranges below the critical micelle concentrations of the surfactants and at 298.2 K. The diffusion coefficient decreases with an increase in the concentration of the surfactants. At a fixed concentration, the diffusion coefficient decreases with an increase in the carbon number of the surfactants. The results are compared with our previous results in sodium dodecyl sulfate (NaDS) solutions. The conductivities of the NaDSO and NaDS solutions were also measured at 298.2 K in the presence and absence of [Fe(phen)3]SO4. In the presence of [Fe(phen)3]SO4, the molar conductivities of the surfactants first decrease, then increase, and finally decrease again with an increase in the concentration of the surfactants.
|
2022-09-06T00:32:42.752Z
|
235,692,730 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1155/2021/6610237",
"MAG": "3163844061",
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "https://downloads.hindawi.com/journals/mpe/2021/6610237.pdf"
}
|
In recent years, banks have begun to realize the importance of Internet banking services and their connection with the banking sector. The main purpose of this article was to find the mediating role of employee innovativeness in the relationship between Internet banking and employee performance of certain banks in the Republic of Congo. A 350-sample size was considered, and a partial least square and structural model equation was used for data analysis. The research results suggested that Internet banking positively affects employee performance and employee innovativeness. They also confirmed that employee innovativeness partially mediates the relationship between Internet banking and employee performance. The theoretical model was built based on Diffusion of Innovation (DOI) Theory, Job Demands-Resources (JD-R) Model, Absorptive Capacity Theory (ACT), and Resource-Based View Theory. This work makes a more accurate contribution to the literature on Internet banking and employee performance. The study further provided recommendations and suggests directions for future studies.
|
2022-09-08T20:24:06.399Z
|
60,653,327 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3233/HSM-1991-10406",
"MAG": "1159480249",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
System Design consists of modeling and of metamodeling. The relationship between these two aspects of System De sign is explained. We apply metamodeling to Value Systems and show the relationship which exists between ethics and metaethics. Whereas ethics takes place in the inquiring sys tem at the object level, metaethics is generated in the inquir ing system at the metalevel. This framework is used to model and metamodel Environmental Ethics and to discuss the Ethics and Metaethics of Conservation.
|
2022-09-10T21:22:10.293Z
|
135,135,250 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.20985/1980-5160.2018.v13n1.1319",
"MAG": "3022847336",
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},
"license": "CCBY",
"status": "GOLD",
"url": "http://www.revistasg.uff.br/index.php/sg/article/download/1319/846"
}
|
The activities of the construction industry generate great negative impacts on the environment. In order to highlight and point out new trends in the processes and materials used, this article aims to identify aspects related to sustainable construction in small and medium-sized constructions. It analyzes concepts and new trends for the construction sector as tools for meeting the requirements of the National Solid Waste Policy, regarding the observation of sustainability principles aimed at the continuous application of preventive environmental strategies. It is an exploratory, bibliographic study, whose purpose was to expand knowledge in terms of sustainable constructions, in order to guarantee familiarity with the theme and to disseminate information that can collaborate with environmental preservation. It presents and discusses the results obtained during technical visits carried out together with works considered sustainable. It concludes that there is a constructive tendency to use techniques and materials for the reduction of waste generation, reuse of water and use of alternative energy and natural vegetation. Although actions aimed at eco-efficiency in Brazilian civil construction have valuable potential in the area of prevention, they are still insufficient to solve the serious environmental problems generated by the sector.
|
2022-01-27T19:12:40.649Z
|
18,885,787 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/TNNLS.2013.2264292",
"MAG": "2092783572",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The construction of a radial basis function (RBF) network involves the determination of the model size, hidden nodes, and output weights. Least squares-based subset selection methods can determine a RBF model size and its parameters simultaneously. Although these methods are robust, they may not achieve optimal results. Alternatively, gradient methods are widely used to optimize all the parameters. The drawback is that most algorithms may converge slowly as they treat hidden nodes and output weights separately and ignore their correlations. In this paper, a new discrete-continuous algorithm is proposed for the construction of a RBF model. First, the orthogonal least squares (OLS)-based forward stepwise selection constructs an initial model by selecting model terms one by one from a candidate term pool. Then a new Levenberg-Marquardt (LM)-based parameter optimization is proposed to further optimize the hidden nodes and output weights in the continuous space. To speed up the convergence, the proposed parameter optimization method considers the correlation between the hidden nodes and output weights, which is achieved by translating the output weights to dependent parameters using the OLS method. The correlation is also used by the previously proposed continuous forward algorithm (CFA). However, unlike the CFA, the new method optimizes all the parameters simultaneously. In addition, an equivalent recursive sum of squared error is derived to reduce the computation demanding for the first derivatives used in the LM method. Computational complexity is given to confirm the new method is much more computationally efficient than the CFA. Different numerical examples are presented to illustrate the effectiveness of the proposed method. Further, Friedman statistical tests on 13 classification problems are performed, and the results demonstrate that RBF networks built by the new method are very competitive in comparison with some popular classifiers.
|
2022-12-21T10:31:19.801Z
|
178,627,655 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.12980/jclm.1.2013c957",
"MAG": "2183960457",
"PubMedCentral": null
},
"license": null,
"status": "GOLD",
"url": "https://doi.org/10.12980/jclm.1.2013c957"
}
|
Muthusamy Ravichandiran, Selvam Thiripurasalini, Vaithilingam Ravitchandirane*, Srinivasa Gopalane, Chelladurai Stella Department of Food and Drug Testing, Puducherry-605 006, India Department of Chemistry, PRIST University, Thanjavur-613403, India Department of Zoology, Kanchi Mamunivar Centre for Post-Graduate Studies, Puducherry-605008, India Department of Forensic Medicine, Omar Al-Mukhtar University, Al-Beida, Libya Department of Oceanography, Alagappa University, Thondi Campus-623409, India Journal of Coastal Life Medicine 2013; 1(4): 273-277
|
2022-12-24T21:01:06.576Z
|
56,027,629 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.1002/1099-0690(20021)2002:2<331::AID-EJOC331>3.0.CO;2-E",
"MAG": "2149350234",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The metal cation (Ba++) binding ability of a family of designed nonconjugated bichromophoric [bis(para-phenylene)- or bis(para-diphenylene)]polyoxamacrocyclic coronands has been studied in acetonitrile in the ground state and in the singlet excited state. The association constants (K) at ambient temperature have been determined from UV absorption and fluorescence data, by use of the LETAGROP-SPEFO programme. The ground state complexes exhibit 1:1 or 1:1 and 2:1 (cation/ligand) stoichiometries and a large variety of association constants, as well as diverse cooperative effects. Remarkably, TTO5O5 {1,4,7,10,13,21,24,27,30,33-decaoxa[13.15]-(1,4)benzenophane} shows a strong binding ability (log β = 10.3) with a positive cooperativity. The apparent association constants measured from stationary fluorescence data were found to be lower in some cases than those observed in the ground state; these results strongly suggest that a transitory photodecomplexation between the metal cation and the phenolic oxygen atoms occurs in the S1 state. An X-ray structure analysis was performed on the barium complex of a related podand and the Ba++ coordination number was found to be 10.
|
2022-02-11T19:35:33.091Z
|
52,912,259 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/aor.13321",
"MAG": "2895638081",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Vacuum-assisted closure (VAC) has been widely used to treat mediastinitis after congenital cardiac surgery, which is associated with a high risk of morbidity and mortality. The aim in this study is to review our 14 cases of mediastinitis treated with VAC therapy after congenital cardiac surgery. We retrospectively reviewed the medical records of 14 congenital heart patients with mediastinitis from January 2012 to March 2017. Patients with fever, wound discharge, sternal dehiscence, a positive wound culture or abscess diagnosed with computed tomography are accepted as mediastinitis. A VAC was applied to all our patients without irrigation or dressing the wound because of sterility concerns. The vacuuming of the wound was either 50 mm Hg or 75 mm Hg according to the sternal intactness. We gradually decreased the pressures and changed the VAC systems once every three days, after wound healing was seen and a negative culture was obtained and VAC was terminated. There were 14 patients (8 male and 6 female) with mediastinitis and all of them were treated using VAC. The mean age of the patients was 6.96 months (ranging from 0.5-26 months). The mean weight was 5.16 kg (2.8-12 kg). Three patients needed extracorporeal membrane oxygenation after the surgery. Mean onset of mediastinitis was 25.3 days. The wound cultures showed methicillin resistant coagulase negative streptococcus and methicillin-sensitive staphylococcus aureus in most cases. Acinetobacter, serratia, pseudomonas, and klebsiella were the other bacterial species seen in cultures. Two patients had mediastinitis symptoms, but their cultures were negative. VAC systems were changed 3.85 times on average. Mean duration of hospital stay was 49.9 days (21-104 days). One patient needed a muscle flap to close the thoracic cavity after mediastinitis. Two patients did not survive. Mediastinitis is a serious postoperative condition in pediatric cardiac surgery patients. Classical wound dressing and irrigation methods are not suitable in mediastinitis for the pediatric age group. Therefore, VAC therapy can be an effective way to successfully treat the situation.
|
2023-01-01T19:24:30.011Z
|
241,294,131 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.18861/ic.2020.15.2.3022",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "https://revistas.ort.edu.uy/inmediaciones-de-la-comunicacion/article/download/3022/3365"
}
|
Los sistemas gubernamentales son, cada vez más, objeto de desconfianza por parte de los ciudadanos. Este panorama se puede explicar a través de múltiples y complejos factores: uno de ellos tiene que ver con la comunicación pública que los voceros institucionales emiten para dar a conocer los planes, las decisiones o las acciones de gobierno. Con base en esa premisa, este artículo realiza un análisis sobre la comunicación gubernamental pública bajo la perspectiva de comunicación responsable y se detiene, particularmente, en un caso de relevancia actual en México: el discurso público del presidente Andrés Manuel López Obrador y su gabinete en los primeros cien días de la gestión iniciada el 1 de diciembre de 2018. El objetivo de este trabajo es revisar, a partir de este caso, el discurso gubernamental de López Obrador y sus funcionarios, basándose en una metodología de desarrollo propio que permite fijar los rasgos básicos que establece la perspectiva de comunicación responsable y clasificar, en tal sentido, el discurso de una figura pública.
|
2022-01-27T03:13:48.879Z
|
148,819,827 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.5070/BP320111924",
"MAG": "2769859457",
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},
"license": null,
"status": null,
"url": null
}
|
This issue of the Berkeley Planning Journal is dedicated to Kaye Bock, the longtime Student Affairs Officer for the Department of City and Regional Planning here at Berkeley. Kaye's death came as a shock to the Berkeley planning community; staff, faculty, students and the roughly 1,000 planners that have survived their planning education in no small part due to Kaye's seemingly endless supply of caring, creativity, and know- how, plus her unwavering determination that you succeed no matter the barriers that you may face.
|
2022-02-09T04:43:34.268Z
|
147,098,839 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.1177/003463733703400211",
"MAG": "2330261887",
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},
"license": null,
"status": null,
"url": null
}
|
meet in America Today; The attitude of Protestant churches. The special position of Lutheranism; The Roman Church in theory and practice, and "The Agencies of Common Thought and Action." Part III. Church and State in the World of Tomorrow; in three chapters discusses: Factors in a right solution; Principles for determining the Social and Political activity of Protestant churches, and finally, the relation of the churches in America to the "Church Universal." There is of necessity quite much repetition and seemingly an undue amount of tediousness, and since this is such a classic-about the only book to take up the subject in all of its ramifications, one could wish it were presented a little more concisely and attractively, and perhaps a little less from the standpoint of the "Federal Council." However, it is a great, rare book, representing an unbelievable amount of toil and search. The preacher, teacher and student must have this book. F. M. POWELL
|
2022-02-09T05:34:23.938Z
|
142,166,992 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.33633/LITE.V3I1.610",
"MAG": "1486520106",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Personal adjustment which is derived from cultural system and social interactions always becomes an actual issue. Likewise, the description of women’s personal adjustment which is reflected through the character of Anju and Sudha in Sister of My Heart and The Vine of Desire written by Chitra Banerjee Divakaruni. The result of the analysis indicates that the description of women’s personal adjustment reflected through the character of Anju and Sudha in Sister of My Heart and The Vine of Desire is influenced by cultural setting in the plot of the novel. Cultural interaction carried out by Anju and Sudha has produced typical different patterns of personal adjustment. In India, Anju and Sudha tend to adjust themselves allopathically, while in America, they tend to adjust themselves autopathically. The typical different patterns of personal adjustment produced by Anju dan Sudha can be seen clearly through the analysis of several factors, such as steps of (1) personal development, (2) conflicts experienced by the characters, and (3) women position in a certain culture.
|
2022-09-04T12:02:51.692Z
|
85,243,741 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5145/KJCM.2009.12.1.48",
"MAG": "2075396830",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Bacillus cereus causes two types of gastrointestinal diseases: emesis and diarrhea. It produces one emetic toxin and nine different enterotoxins. In March 2008, eight of a family became sick after eating slices of raw fish. We isolated emetic toxin producing B. cereus from the stools of 6 patients and 2 subclincal humans. In this study, the presence of enterotoxin genes, such as those of haemolysin BL (Hbl), nonhemolytic enterotoxin (Nhe), B. cereus enterotoxin T (BceT), enterotoxin FM (EntFM), cytotoxin K (cytK) and cereulide were assayed by polymerase chain reaction (PCR) methods. Their enterotoxin activities were assayed using the BCETRPLA, Tecra ELISA kit and Hep-2 vacuole activity. Bacterial isolates were subtyped by pulsed-field gel electrophoresis (PFGE). This study demonstrates the emetic toxin-producing stains of B. cereus in clinical specimens, for the first time in the Republic of Korea. (Korean J Clin Microbiol 2009;12:48-52)
|
2022-09-06T11:18:43.290Z
|
214,144,203 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.31487/j.ajscr.2020.01.01",
"MAG": "3006582861",
"PubMedCentral": null
},
"license": "CCBY",
"status": "HYBRID",
"url": "https://doi.org/10.31487/j.ajscr.2020.01.01"
}
|
Objective: We report two cases of cavernous hemangioma of the temporal bone and review the relevant
literature.
Design: Retrospective report of two cases and review of the English literature concerning cavernous
hemangiomas of the ear via PubMed.
Results: A 46-year-old male was found to have a large external auditory canal vascular mass. Excision of
mass with endaural approach was taken and diagnosis was confirmed with histopathology. Also, a 35-yearold female was found to have an internal auditory canal vascular mass. Retrosigmoid craniotomy was
performed for resection and diagnosis was confirmed with histopathology. Less than 120 case reports of
cavernous hemangiomas of the ear were identified and analyzed.
Conclusion: Cavernous hemangiomas of the ear are rare vascular tumors of the head and neck that can
cause symptoms requiring histopathological diagnosis and surgical treatment.
|
2022-01-27T08:45:12.519Z
|
28,010,413 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.1093/BJA/59.8.1027",
"MAG": "1966689633",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The effect of selective mechanical ventilation of dependent lung regions were studied in anaesthetized horses (mean weight 486 kg) in dorsal recumbency. Blood-gas measurements were performed with the horse in the lateral position during spontaneous breathing (before selective intubation) and in dorsal recumbency during spontaneous breathing, general mechanical ventilation, and spontaneous breathing + selective mechanical ventilation. Arterial oxygen tension (PaO2) was 32.3 kPa in the lateral position during spontaneous breathing with a high inspired oxygen fraction (FlO2 greater than 92%). In dorsal recumbency PaO2 decreased to 10.9 kPa during spontaneous breathing and was not significantly affected by general mechanical ventilation (PaO2 12.6 kPa). The institution of selective mechanical ventilation with a selective positive end-expiratory pressure (PEEP) of 20 cm H2O caused a marked increase in PaO2 to an average of 35.3 kPa. It is concluded that selective intubation of dependent regions in the diaphragmatic lobes is a feasible procedure and that selective mechanical ventilation with PEEP markedly improves arterial oxygenation in the anaesthetized horse in dorsal recumbency.
|
2022-09-16T08:33:04.440Z
|
59,484,736 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.14740/JCGO.V5I3.408",
"MAG": "2529463195",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Background: Preeclampsia can be defined as a pregnancy-specific syndrome that a group of pathological signs and symptoms occur simultaneously without known causes. This study aimed to determine the effect of season on the prevalence of preeclampsia in pregnant women referring to Sanandaj Besat Hospital during 2013 - 2014. Methods: This descriptive study was conducted on 363 pregnant women referring to Sanandaj Besat Hospital during 2013 - 2014. Data were collected from medical records of pregnant women who were hospitalized because of preeclampsia and analyzed with STATA-11 and Chi-square test. Results: The results showed that the mean age of women diagnosed with preeclampsia was 30.5 ± 6.60 years. The prevalence of preeclampsia in urban and rural pregnant women was 10% and 4%, respectively. The incidence of preeclampsia was 30% during the winter months. There was no statistically significant relationship between the season of conception and the month of preeclampsia (P = 0.67). Conclusions: Based on the findings of this study, it can be said that the risk of preeclampsia in cold seasons is more than warmer seasons and its incidence is lower in urban multiparous women. J Clin Gynecol Obstet. 2016;5(3):81-84 doi: http://dx.doi.org/10.14740/jcgo408w
|
2022-12-11T23:05:55.404Z
|
23,784,576 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4161/cc.8.12.8815",
"MAG": "1975460788",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://www.tandfonline.com/doi/pdf/10.4161/cc.8.12.8815?needAccess=true"
}
|
Here I overview the accompanying three reports on suppression of cellular senescence with inhibitors of mTOR, PI-3K and MEK. How can growth inhibitors suppress senescence? May these aging-suppressants decelerate organismal aging? To answer these questions, we need to reconsider the meaning of aging.
|
2022-12-13T05:13:53.540Z
|
145,888,573 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1039/c9ra00253g",
"MAG": "2938666270",
"PubMedCentral": "9062538"
},
"license": "CCBYNC",
"status": "GOLD",
"url": "https://pubs.rsc.org/en/content/articlepdf/2019/ra/c9ra00253g"
}
|
A novel positively charged composite nanofiltration (NF) membrane with tunable active layer structure was successfully developed via interfacial polymerization on a polysulfone (PSF) ultrafiltration (UF) membrane surface, using polyethyleneimine (PEI) as the monomer of the aqueous phase, and a mixture of isophthaloyl dichloride (IPC) and tri-mesoyl chloride (TMC) as the monomer of the organic phase. Interestingly, a synergetic effect of the mass ratio of IPC and TMC was observed on the pore size and the structure of the active layer of the resultant polyamide (PA)/polysulfone (PSF) composite NF membrane. The rejection (R) to the inorganic electrolytes increased with the mass ratio of IPC to TMC, while the permeate flux (F) escalated up to a 1 : 1 mixing ratio of IPC to TMC and dropped at higher mixing ratios. The rejection to different inorganic electrolytes decreased in the order of ZnCl2, MgCl2, CaCl2, CuCl2, MgSO4, NaCl, and Na2SO4. At ambient temperature and 0.4 MPa, the optimized membrane demonstrated R and F to 1 g L−1 MgCl2 aqueous solution as 98.1% and 27.6 L m−2 h−1, respectively. Its rejection to various dyes reduced significantly in the order of cationic red X-GTL (100%), rhodamine B (94.2%), cationic gold yellow X-GL (93.5%), and brilliant blue KN-R (43.9%), in agreement with the decrease in the molecular weight (Mw) and the overall charges of the dye.
|
2022-12-21T17:34:07.410Z
|
17,073,458 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.3390/nu7053240",
"MAG": "1800753885",
"PubMedCentral": "4446749"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.mdpi.com/2072-6643/7/5/3240/pdf?version=1430900318"
}
|
Dietary validation studies of self-reported fruit and vegetable intake should ideally include measurement of plasma biomarkers of intake. The aim was to conduct a validation study of self-reported fruit and vegetable intakes in adults, using the Australian Eating Survey (AES) food frequency questionnaire (FFQ), against a range of plasma carotenoids. Dietary intakes were assessed using the semi-quantitative 120 item AES FFQ. Fasting plasma carotenoids (α- and β-carotene, lutein/zeaxanthin, lycopene and cryptoxanthin) were assessed using high performance liquid chromatography in a sample of 38 adult volunteers (66% female). Significant positive correlations were found between FFQ and plasma carotenoids for α-carotene, β-carotene and lutein/zeaxanthin (52%, 47%, 26%, p < 0.001, 0.003, 0.041; respectively) and relationships between plasma carotenoids (except lycopene) and weight status metrics (BMI, waist circumference, fat mass) were negative and highly significant. The results of the current study demonstrate that carotenoid intakes as assessed by the AES FFQ are significantly related to plasma concentrations of α-carotene, β-carotene and lutein/zeaxanthin, the carotenoids commonly found in fruit and vegetables. Lower levels of all plasma carotenoids, except lycopene, were found in individuals with higher BMI. We conclude that the AES can be used to measure fruit and vegetable intakes with confidence.
|
2022-12-25T16:54:41.437Z
|
95,390,778 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.1002/JHET.5570180823",
"MAG": "2952217485",
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},
"license": null,
"status": null,
"url": null
}
|
A recent report describing the preparation of 2-(substituted-amino)-3,4-dihydro-5H-1,3,4-benzotriazepin-5-ones (3), by the cyclodesulfurization of hydrazides prepared from o-aminobenzoylhydrazine (1) and isothiocyanates, is erroneus. The products resulting from this reaction sequence are, instead, 2-(substituted-amino)-5-(o-aminophenyl)-1,3,4-oxadiazoles (4). Alternate syntheses of the oxadiazoles led to the correct structural assignments.
|
2022-09-08T13:57:20.832Z
|
201,617,287 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3233/SHTI190347",
"MAG": "2974107859",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The quality of software is high in medical devices due to the strict regulatory requirements and their implementation in the software development processes through the use of the IEC 62304 standard. The goal of this standard revision project was to extend the scope of the standard to all health software and also to bring the requirements of the 12 year old standard back to the state-of-the-art including provisions for cybersecurity. The joint IEC/SC62A and ISO/TC215 project team revised the standard and adapted its risk management, usability, and security requirements to serve both the medical device industry and the overall health software industry. The resulting second version of the standard has gone through a multistage global voting process to achieve a consensus of the requirements to serve both these communities. The resulting standard has potential to have a major impact on the quality of software used in health care globally.
|
2022-09-15T23:32:11.608Z
|
102,742,509 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.1021/ACSCATAL.7B03804",
"MAG": "2781662593",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
CO2 is selectively hydrogenated to HCO2H or hydrocarbons (HCs) by RuFe nanoparticles (NPs) in ionic liquids (ILs) under mild reaction conditions. The generation of HCO2H occurs in ILs containing basic anions, whereas heavy HCs (up to C21 at 150 °C) are formed in the presence of ILs containing nonbasic anions. Remarkably, high values of TONs (400) and a TOF value of 23.52 h–1 for formic acid with a molar ratio of 2.03 per BMI·OAc IL were obtained. Moreover, these NPs exhibited outstanding abilities in the formation of long-chain HCs with efficient catalytic activity (12% conversion) in a BMI·NTf2 hydrophobic IL. The IL forms a cage around the NPs that controls the diffusion/residence time of the substrates, intermediates, and products. The distinct CO2 hydrogenation pathways (HCO2H or FT via RWGS) catalyzed by the RuFe alloy are directly related to the basicity and hydrophobicity of the IL ion pair (mainly imposed by the anion) and the composition of the metal alloy. The presence of Fe in the RuFe alloy pr...
|
2022-12-15T18:14:14.396Z
|
27,213,520 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.1073/pnas.0802789105",
"MAG": "2158381212",
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},
"license": null,
"status": "GREEN",
"url": "https://europepmc.org/articles/pmc2438218?pdf=render"
}
|
The heterodisaccharide lactose (1,4-O-β-d-galactopyranosyl-d-glucose) induces cellulase formation in the ascomycete Hypocrea jecorina (= Trichoderma reesei). Lactose assimilation is slow, and the assimilation of its β-d-galactose moiety depends mainly on the operation of a recently described reductive pathway and depends less on the Leloir pathway, which accepts only α-d-galactose. We therefore reasoned whether galactomutarotase [aldose 1-epimerase (AEP)] activity might limit lactose assimilation and thus influence cellulase formation. We identified three putative AEP-encoding genes (aep1, aep2, aep3) in H. jecorina, of which two encoded intracellular protein (AEP1 and AEP2) and one encoded an extracellular protein (AEP3). Although all three were transcribed, only the aep3 transcript was detected on lactose. However, no mutarotase activity was detected in the mycelia, their cell walls, or the extracellular medium during growth on lactose. Therefore, the effect of galactomutarotase activity on lactose assimilation was studied with H. jecorina strains expressing the C-terminal galactose mutarotase part of the Saccharomyces cerevisiae Gal10. These strains showed increased growth on lactose in a gene copy number-dependent manner, although their formation of extracellular β-galactosidase activity and transcription of the genes encoding the first steps in the Leloir and the reductive pathway was similar to the parental strain QM9414. Cellulase gene transcription on lactose dramatically decreased in these strains, but remained unaffected during growth on cellulose. Our data show that cellulase induction in H. jecorina by lactose requires the β-anomer of d-galactose and reveal the lack of mutarotase activity during growth on lactose as an important key for cellulase formation on this sugar.
|
2022-12-16T20:20:30.144Z
|
102,232,174 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1021/OP2001047",
"MAG": "2327586647",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Three different continuous flow strategies for the generation of important 4-aryl-2-butanone derivatives including the anti-inflammatory drug nabumetone [4-(6-methoxy-2-naphthalenyl)-2-butanone] and the aroma compounds raspberry ketone [4-(4-hydroxyphenyl)-2-butanone] and its methyl ether [4-(4-methoxyphenyl)-2-butanone] were evaluated. All three protocols involve the initial preparation of the corresponding 4-aryl-3-buten-2-ones via Mizoroki–Heck, Wittig, or aldol strategies, which is then followed by selective hydrogenation of the C═C double bond to the desired 4-aryl-2-butanones. The synthetic routes to 4-aryl-3-buten-2-ones were first optimized/intensified on small scale to reaction times of 1–10 min using batch microwave heating technology and then translated to a scalable continuous flow process employing commercially available stainless steel capillary tube reactors. For the synthesis of 4-(4-methoxyphenyl)-3-buten-2-one a further scale-up using a custom-built mesofluidic mini-plant flow system cap...
|
2022-12-19T00:54:04.052Z
|