corpusid
int64 5
255M
| openaccessinfo
dict | abstract
stringlengths 1
10k
| updated
stringlengths 20
24
|
|---|---|---|---|
187,146,425 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1177/239700220301700424",
"MAG": "2894012544",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
dere die Integration von gesundheitsbeeinträchtigenden Arbeitsbelastungen, die den individuellen Verhaltensspielraum für krankheitsbedingtes Fehlen mitunter stark beeinflussen, sowie Entstehungsund Diffusionsprozesse von Normen über krankheitsbedingtes Fehlen. Ferner ist empirische Forschung zu konkreten Inhalten von psychologischen Verträgen – insbesondere auch zu Gerechtigkeitsempfindungen in Zusammenhang mit krankheitsbedingtem Fehlen – notwendig. Im Hinblick auf die Kohortenanalyse gilt es insbesondere das Kohortenkonzept selbst zu spezifizieren. So bleibt beispielsweise noch zu klären, welche Rolle Interaktionen zwischen Kohortenmitgliedern oder auch eine Art Kohortenidentität für das Herausbilden von Normen über krankheitsbedingtes Fehlen und für das Verhalten der Kohortenmitglieder spielen. Auch hier besteht neben theoretisch-konzeptionellem Forschungsbedarf auch (qualitativ-)empirischer.
|
2022-09-02T02:43:52.839Z
|
238,749,149 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3389/fvets.2021.757759",
"MAG": null,
"PubMedCentral": "8551392"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.frontiersin.org/articles/10.3389/fvets.2021.757759/pdf"
}
|
Interferon tau (IFNT), a pregnancy recognition signal in ruminants, promotes the establishment of embryo implantation by inducing the expression of interferon-stimulated genes (ISGs) via the Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway. However, the precise regulatory mechanism of IFNT in goat embryo implantation remains largely unknown. In this study, we performed RNA sequencing of goat endometrial epithelial cells (gEECs) with or without 20 ng/mL IFNT treatment. Differential comparison showed that there were 442 upregulated differentially expressed genes (DEGs) and 510 downregulated DEGs. Bioinformatic analyses revealed that DEGs were significantly enriched in immune-related functions or pathways. The qRT-PCR validation results showed that the expression levels of STAT family members (STAT1, STAT2, and STAT3) were significantly upregulated in gEECs after IFNT treatment, which is in agreement with the RNA-seq data. Meanwhile, the protein levels of p-STAT1 and p-STAT3 increased significantly in gEECs after 6 and 24 h of IFNT treatment, respectively. Further in vivo experiments also confirmed that both mRNA and protein phosphorylation levels of STAT1 and STAT3 in the uterus on day 18 of pregnancy (P18) were significantly increased compared to those on day 5 (P5) and day 15 of pregnancy (P15). On P5, STAT1 and STAT3 proteins were primarily located in the uterine luminal epithelium (LE) and glandular epithelium (GE), and were also detected in the stromal cells. The intense immunostaining of STAT1 and STAT3 proteins were decreased on P15 and then increased on P18, especially in the superficial GE and subepithelial stromal cells. Moreover, p-STAT1 and p-STAT3 were highly expressed in the deep GE on P18. Collectively, these results highlight the role of IFNT in regulating endometrial receptivity in gEECs and uncover the temporal and spatial changes in the expression of STAT1/3 during embryo implantation in the goat endometrium.
|
2022-11-18T09:01:26.698Z
|
23,188,802 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1097/01.rli.0000251569.01317.60",
"MAG": "2026965730",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Rationale and Objectives:Reliable noninvasive detection of stenoses with multislice computed tomography (MSCT) is feasible. This study's aim was to analyze the agreement, correlation, and reliability of MSCT with conventional coronary angiography as the reference standard for quantification of coronary artery stenoses. Materials and Methods:A total of 118 significant (at least 50%) coronary artery stenoses with a reference vessel diameter of at least 1.5 mm in 62 patients were analyzed by MSCT using 16 detector rows (Aquilion, Toshiba, Otawara, Japan), multisegment reconstruction, and voxel sizes of 0.35 × 0.35 × 0.5 mm3. The degree of stenosis on MSCT and quantitative coronary angiography (QCA) was measured by correlating the difference between the reference vessel diameter (average of 2 measurements directly proximal and distal to the stenosis) and the stenotic vessel diameter to the reference vessel diameter. Results:Correlation between the percent diameter stenosis determined by MSCT (78.2 ± 13.6%) and QCA (76.0 ± 14.8%) was significant (P < 0.001) but only moderately so (R = 0.51). Bland-Altman analysis revealed no systematic under- or overestimation with MSCT but large limits of agreements (±27.6%). Also the limits of agreement for interobserver agreement (reliability) of MSCT data were considerably large (±24.8%). Among the 27 coronary artery stenoses with a reference diameter of at least 3.5 mm, there was improved correlation (R = 0.80) and the limits of agreement between MSCT and QCA were significantly smaller (±17.3%, P < 0.008). The agreement between MSCT and QCA was not significantly different for stenoses with no calcification or only calcium spots (±28.2%) as compared with those with moderate-or-severe calcifications (±27.3%; P = 0.8). MSCT allowed correct classification of coronary stenoses into low-grade (below 75%) and high-grade stenoses (at least 75%), in 62% (73 of 118). Conclusions:The accuracy and reliability of coronary artery stenosis quantification with MSCT using isotropic voxel sizes and multisegment reconstruction is still too low to recommend routine clinical application because of rather low agreement, correlation, and reliability. Despite these limitations, the current results demonstrate the potential of MSCT for reliable and accurate quantification of coronary artery stenoses in the near future provided that further improvements in spatial and temporal resolution will be achieved.
|
2022-12-12T09:58:24.899Z
|
7,447,002 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1248/bpb.b17-00243",
"MAG": "2726036270",
"PubMedCentral": null
},
"license": null,
"status": "GOLD",
"url": "https://www.jstage.jst.go.jp/article/bpb/40/7/40_b17-00243/_pdf"
}
|
Chemotherapy-induced peripheral neuropathy (CIPN), characterized by symptoms of paresthesia, dysesthesia, numbness, and pain, is a common adverse effect of several chemotherapeutic agents, including platinum-based agents, taxanes, and vinca alkaloids. However, no effective prevention or treatment strategies exist for CIPN because the mechanisms underpinning this neuropathy are poorly understood. Recent accumulating evidence suggests that some transient receptor potential (TRP) channels functioning as nociceptors in primary sensory neurons are responsible for CIPN. In this review, we focus on the specific roles of redox-sensitive TRP ankyrin 1 (TRPA1), which was first reported to be a cold nociceptor, in acute cold hypersensitivity induced by oxaliplatin, a platinum-based agent, because it induces a peculiar cold-triggered CIPN during or within hours after its infusion. Oxaliplatin-induced rapid-onset cold hypersensitivity is ameliorated by TRPA1 blockade or deficiency in mice. Consistent with this, oxaliplatin enhances the responsiveness of TRPA1 stimulation, but not of TRP melastatin 8 (TRPM8) and TRP vanilloid 1 (TRPV1), in mice and cultured mouse dorsal root ganglion neurons. These responses are mimicked by an oxaliplatin metabolite, oxalate. In human TRPA1 (hTRPA1)-expressing cells, oxaliplatin or oxalate causes TRPA1 sensitization to reactive oxygen species (ROS) by inhibiting prolyl hydroxylases (PHDs). Inhibition of PHD-mediated hydroxylation of a proline residue within the N-terminal ankyrin repeat of hTRPA1 endows TRPA1 with cold sensitivity by its sensing of cold-evoked ROS. This review discusses these findings and summarizes the evidence demonstrating that oxaliplatin-induced acute cold hypersensitivity is caused by TRPA1 sensitization to ROS via PHD inhibition, which enables TRPA1 to convert ROS signaling into cold sensitivity.
|
2022-12-15T03:37:09.063Z
|
192,520,709 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.13039/501100003329",
"MAG": "2921884278",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Miguel Cabanas Bravo / Wifredo Rincon Garcia (editores): El arte y la recuperacion del pasado reciente. Madrid: Editorial CSIC (Col. “Biblioteca de Historia del Arte”, no 25), 2015, 400 pp. (ISBN: 978-84-00-10029-2; e-ISBN: 978-84-00-10030-8)
|
2022-02-08T08:47:11.613Z
|
72,087,327 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3329/JBCPS.V27I1.4239",
"MAG": "2049966446",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Objective: our initial experience with 15 patients operated on without general anesthesia is reviewed to explore the validity of our surgical strategy. Material and Methods: 15 males between 45-65 years underwent off-pump coronary artery bypass grafting (OPCAB) with high thoracic epidural anesthesia (HTEA) between April to September 2006. Target vessels involved were the single vessel in 5, double vessel in 7 and triple vessel disease in 3 patients. CABG was performed through a median sternotomy in 13 patients and through limited access in 2 patients. Results: Among 15 patients, patients remain awake or were lightly sedated breathing spontaneously in 9 cases. In 3 patients pneumothorax was observed during surgical intervention. Average length of ICU stay was 1 day (range 1 to 2 days). In all cases, patients showed lack of treatable cardiac dysrhythmias and stable haemodynamic response to surgical procedures including cardiac positioning and direct handling. Conclusion: CABG under epidural anesthesia appeared to be safe for and satisfying to the patients. Stable haemodynamics, low incidence of cardiac dysrhythmias and early recovery and discharge from ICU and low cost involvement are among the benefits that can be derived from this technique at least in selected patients. High thoracic epidural anaesthesia was proved to be very efficient in achieving, somatosensory & motor block in the chest, which inturn facilitating CABG without endotracheal general anaesthesia in selected patients. CABG in an awake patient without endotracheal general anaesthesia was first performed in October 1998 with high thoracic epidural block1. Since then, similar cases had been reported in the literature to decrease the invasiveness of the CABG procedure. This report presents our initial experience in 15 patients which was performed during a time period of 6 months. DOI: 10.3329/jbcps.v27i1.4239 J Bangladesh Coll Phys Surg 2009; 27: 22-24
|
2022-02-11T10:12:51.606Z
|
20,788,634 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1515/cclm-2016-0427",
"MAG": "2509283331",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
*Corresponding author: Abdurrahman Coskun, MD, Acibadem University, School of Medicine, Department of Medical Biochemistry, Istanbul, Turkey, E-mail: Coskun2002@gmail.com; and Acibadem Labmed Clinical Laboratories, Istanbul, Turkey Mustafa Serteser and Ibrahim Unsal: Acibadem University, School of Medicine, Department of Medical Biochemistry, Istanbul, Turkey; and Acibadem Labmed Clinical Laboratories, Istanbul, Turkey Resul Altinayak: Acibadem Labmed Clinical Laboratories, Istanbul, Turkey Letter to the Editor
|
2022-02-12T21:48:59.529Z
|
20,145,855 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3390/nano7110397",
"MAG": "2770294934",
"PubMedCentral": "5707614"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.mdpi.com/2079-4991/7/11/397/pdf?version=1511077682"
}
|
We report spectral splitting behaviors based on Fano resonances in a novel simple planar metasurface composed of gold nanobars and nanorings. Multiple plasmonic modes and sharp Fano effects are achieved in a broadband transmittance spectrum by exploiting the rotational symmetry of the metasurface. The transmission properties are effectively modified and tuned by modulating the structural parameters. The highest single side Q-factor and FoM which reaches 196 and 105 are observed at Fano resonances. Our proposed design is relatively simple and can be applied for various applications such as multi-wavelength highly sensitive plasmonic sensors, switching, and slow light devices.
|
2022-12-02T12:05:06.274Z
|
120,200,824 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1088/0143-0807/15/3/009",
"MAG": "1975646235",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The extensible pendulum is studied numerically to illustrate the Hamiltonian transition to chaos. This is an apparently simple system which is well suited to explain concepts related with the onset of chaos. Using Poincare sections we exhibit the low-energy regular motion and the coexistence of stochastic and regular motion at intermediate energies. We employ other diagnostic techniques for checking our conclusions.
|
2022-12-09T09:04:46.713Z
|
3,292,325 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1264/JSME2.23.134",
"MAG": "1968944956",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A trial was conducted to suppress bacterial wilt of tomato (BWT) caused by Ralstonia solanacearum using biocontrol agents (BCAs) isolated from soils in Kalimantan, Indonesia. Five isolates were selected from 270 isolates as better performing BCAs through screening four times using a pumice medium. The isolates selected were identified as Burkholderia nodosa, Burkholderia sacchari, Burkholderia pyrrocinia and Burkholderia terricola according to 16S rDNA sequences, fatty acid composition and carbon source utilization patterns. Among them, B. nodosa G5.2.rif1 had significant suppressive effects on Fusarium wilt of tomato (FWT) and spinach (FWS) as well as BWT. When B. nodosa G5.2rif1 was inoculated into a pumice medium in combination with sucrose, it showed even more stable disease suppression for BWT, but not for FWS. This suppression was considered to mainly occur through competition for nutrients. In two times greenhouse experiments for BWT using pots comparable in size to those used commercially, B. nodosa G5.2rif1 significantly suppressed the disease index by 33-79%, with no inhibitory effects on the growth, yield and quality of tomatoes.
|
2022-12-27T19:54:31.195Z
|
24,330,969 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/ICSE-C.2017.100",
"MAG": "2621305049",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Developers write unit tests together with programcode, and then maintain these tests as the program evolves. Sincewriting good tests can be difficult and tedious, unit tests canalso be generated automatically. However, maintaining these tests(e.g., when APIs change, or, when tests represent outdated andchanged behavior), is still a manual task. Because automaticallygenerated tests may have no clear purpose other than coveringcode, maintaining them may be more difficult than maintainingmanually written tests. Could this maintenance be avoided bysimply generating new tests after each change, and disposingthe old ones? We propose disposable testing: Tests are generatedto reveal any behavioral differences caused by a code change, and are thrown away once the developer confirms whetherthese changes were intended or not. However, this idea raisesseveral research challenges: First, are standard automated testgeneration techniques good enough to produce tests that may berelied upon to reveal changes as effectively as an incrementallybuilt regression test suite? Second, does disposable testing reducethe overall effort, or would developers need to inspect moregenerated tests compared to just maintaining existing ones?
|
2022-12-30T00:38:19.020Z
|
30,994,617 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/j.1365-2044.1991.tb09814.x",
"MAG": "2039343493",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
ventilation. We noted the potential for problems, because all tracheostomy tubes in our hospital are without a Murphy eye, and it is impossible to fashion one due to the distal position of the cuff. In retrospect, an early ventilation with the Servo 900C ventilator. tracheostomy may have been more beneficial to the patient, allowing a smoother course of weaning. This case clearly demonstrates the very real problem of physical obstruction of a tracheal tube by the trachea, and the benefit of a Murphy eye in such cases. It also served to remind us of the cycling features of pressure supported
|
2022-02-12T12:08:42.107Z
|
26,494,566 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/PIMRC.2000.881583",
"MAG": "1934076227",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The performance of the satellite communication system is limited by cochannel interference and multipath fading. In the present work, an iterative MMSE interference suppression in encoded TDMA satellite systems is proposed. Diversity of received signals at different hubs is assumed available and used to enable decoding of cochannel signals. The decoder outputs are fed back to help the cochannel interference suppression by employing a MMSE-base scheme. This process iterates as the decoder outputs converge to the transmitted symbols. A similar idea is also used to estimate channel response.
|
2022-02-12T16:01:18.715Z
|
84,057,178 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/01140671.1992.10418065",
"MAG": "1967742924",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Abstract The incorporation of 14C-leaf photosynthate into the free amino acids of the maturing fruit and fruit stalk of kiwifruit (Actinidia deliciosa) was investigated. In February 14C in the fruit core was found mainly in glutamine, and in the inner and outer cortex in glutamine and aspartic acid. Higher amounts of radioactivity were found in aspartic acid of the outer cortex than in other tissues. Increasing amounts of radioactivity were apportioned to arginine in the core at the stem end of the fruit during a 48-h period. As the fruit matured, increasing amounts of radioactivity in the core were found in glutamic acid. In the fruit stalk, 14C was found predominantly in glutamic acid, glutamine, and aspartic acid. The results indicated that: (1) arginine is synthesised in situ in the fruit and fruit stalk; (2) asparagine is likely to be synthesised early in fruit development; and (3) glutamic acid, serine, γ-aminobutyric acid, and alanine are likely to be transported from the leaf to the fruit.
|
2022-10-06T14:14:30.824Z
|
149,544,283 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.33541/REGULA",
"MAG": "2905255064",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
306 Abstract : T his study was conducted to represent the importance of professionalism of Sunday school teacher toward understanding of material taught to 9-12-year-old students (youth class) at GBI Meruya Jakarta Barat. In this study, the researcher wanted to know how significant the effect of professionalism of Sunday school teacher toward understanding of material. The data of this research is quantitative where the method of this research is survey of correlation or the effect between the variables investigated. The researcher, in this case, wanted to test the hypothesis related to dependent and independent variables. The independent variable is professionalism of Sunday school teacher (X) and the dependent variable is understanding of material (Y). The population of this research is 9-12-year-old students (youth class) at GBI Meruya Jakarta Barat. To collect the data, the researcher used questionnaire form answered in research sample. Based on the result, it is known that tcount (4.097) > ttable (2.048), so H0 was accepted and Ha was rejected. It means that professionalism of Sunday school teacher affected toward the understanding of material taught to 9-12-year-old students (youth class) (Y) at GBI (gereja Bethel Indonesia) Meruya Jakarta Barat. Based on the result above, it was found that determination coefficient (r square) reaches 0.375. Thus, the effect of teacher variable professionalism (X) toward understanding of material taught to 9-12-year-old students (youth class) (Y) at GBI (gereja Bethel Indonesia) Meruya Jakarta Barat is 37.5%, while the rest (37.5%) was affected by another factor not researched. Keywords: Professionalism of Sunday School Teacher, Student Understanding A bstrak: Dalam penelitian ini peneliti ingin mengetahui seberapa pengaruh profesionalisme guru Sekolah Minggu terhadap pemahaman materi. Adapun metode yang dilakukan dalam penelitian ini adalah kuantitatif dimana jenis penelitian yang digunakan oleh penulis ini yaitu metode survei berbentuk korelasi atau pengaruh antar variabel yang diteliti. Dalam hal ini peneliti bertujuan untuk menguji hipotesis yang menyatakan pengaruh antar variabel bebas dengan variabel terikat. Variabel bebas dalam skripsi ini adalah Profesionalime guru Sekolah Minggu (X) dan variabel terikatnya adalah Pemahaman materi (Y). Populasi dalam penelitian ini adalah anak-anak Sekolah Minggu pada Usia 9-12 tahun (kelas besar) Gereja Bethel Indonesia (GBI) Taman Meruya, Jakarta Barat. Untuk pengumpulan data penelitian ini digunakan angket yang disusun oleh peneliti dan dijawab pada sampel penelitian. Berdasarkan hasil dapat diketahui bahwa thitung (4.097) > ttabel (2.048) jadi H0 ditolak dan Ha diterima, berarti profesionalisme guru sekolah minggu (X) berpengaruh terhadap pemahaman materi yang diajarkan pada anak usia 9-12 (kelas besar) tahun di GBI Taman Meruya,Jakarta Barat, sehingga hipotesis yang menyatakan bahwa ada hubungan yang positif dan signifikan antara pengaruh profesionalisme guru terhadap pemahaman materi yang diajarkan pada anak usia -12 tahun di Gereja Bethel Indonesia (GBI) Taman Meruya, Jakarta Barat. Dan Dari hasil pengujian di atas diperoleh nilai koefisien determinasi (R Square) sebesar 0.375. Jadi sumbangan pengaruh dari variabel profesionalisme guru (X) terhadap pemahaman materi yang diajarkan pada anak Usia 9 -12 tahun (Y) di Gereja Bethel Indonesia (GBI) Meruya, Jakarta Barat adalah sebesar 37.5%, sedangkan sisanya (100% - 37.5%=62.5%) dipengaruhi oleh faktor lain yang tidak diteliti. Kata Kunci : Profesionalisme Guru Sekolah Minggu, Pemahaman Murid
|
2022-12-05T15:27:46.657Z
|
36,089,631 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1534/GENETICS.104.036962",
"MAG": "1990305653",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Constitutive stable DNA replication (cSDR) is a mechanism for replisome loading in Escherichia coli K-12. This occurs in a dnaA-independent fashion in an rnhA mutant. cSDR is dependent on recA, priA, and transcription. In this report, it is shown that dnaA rnhA mutants using cSDR for initiation of their DNA replication additionally require priB, but not priC, for viability. Two subtle priA missense mutations either eliminated the ability to grow using cSDR (priA301 C479Y) or resulted in very small colonies (priA300 K230R). DnaC809, a priA suppressor, failed to allow priA or priB mutants to grow using cSDR to initiate DNA replication. Furthermore, unlike dnaC+ strains, dnaC809 strains require priC for cSDR. DnaC809,820, a priC-independent suppressor of priA2::kan phenotypes, allowed priA and priC (but not priB) mutants to grow using cSDR to initiate DNA replication. It is also shown that rep and rnhA mutations are synthetically lethal. DnaC809 and dnaC809,820 mutations suppress this lethality. Rep is further shown to be required for cSDR in a dnaC809 strain. A model whereby these different sets of replication restart proteins interact preferentially with substrates associated with either RecA or SSB during replication restart and cSDR, respectively, is proposed.
|
2022-12-09T23:34:54.466Z
|
108,839,946 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4028/www.scientific.net/AMR.255-260.881",
"MAG": "2007133988",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
According to the structural characteristics and the surrounding environment of partially cable-stayed bridge, an asymmetric construction method combinded with support cast-in-place and cantilever casting is applied for main girder construction, based on project of Yuyao cable-stayed bridge. Its basic idea is as follows: One deck section is concreted with brackets in advance, which to offer counterweight for basket construction symmetrically. The technical features and construction key point are described in detail, which provides reference for similar bridge construction.
|
2022-12-14T21:48:51.956Z
|
8,971,747 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1101/GAD.1317105",
"MAG": "2150598386",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Expression of the Arabidopsis CGS1 gene that codes for cystathionine gamma-synthase is feedback regulated at the step of mRNA stability in response to S-adenosyl-L-methionine (AdoMet). A short stretch of amino acid sequence, called the MTO1 region, encoded by the first exon of CGS1 itself is involved in this regulation. Here, we demonstrate, using a cell-free system, that AdoMet induces temporal translation elongation arrest at the Ser-94 codon located immediately downstream of the MTO1 region, by analyzing a translation intermediate and performing primer extension inhibition (toeprint) analysis. This translation arrest precedes the formation of a degradation intermediate of CGS1 mRNA, which has its 5' end points near the 5' edge of the stalled ribosome. The position of ribosome stalling also suggests that the MTO1 region in nascent peptide resides in the ribosomal exit tunnel when translation elongation is temporarily arrested. In addition to the MTO1 region amino acid sequence, downstream Trp-93 is also important for the AdoMet-induced translation arrest. This is the first example of nascent peptide-mediated translation elongation arrest coupled with mRNA degradation in eukaryotes. Furthermore, our data suggest that the ribosome stalls at the step of translocation rather than at the step of peptidyl transfer.
|
2022-12-19T19:54:19.754Z
|
161,670,764 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1163/EJ.9789004176300.I-256.46",
"MAG": "933558717",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
There is some very curious evidence about Louis IX's attitude towards lay preaching in general. It is well known that the king was a big supporter of the beghards and beguines, laymen and laywomen who led devout communitarian though non-cloistered and non-professed lives in the towns of northern France as well as throughout the Low Countries, the Rhineland, and parts of southern Europe. He gave them property and otherwise endowed them. He also liked and energetically supported the two largest mendicant orders, Dominicans and Franciscans, as well as their smaller evangelical counterparts. In any case, just as his children, male and female, patently constituted the most appropriate audience for his parental exhortations, it was precisely Dominican brothers and Franciscan nuns who might most appreciate and be appropriate for the king's preacherly advice. Keywords: Dominican brothers; Franciscan nuns; Louis IX; preaching
|
2022-12-20T02:37:37.972Z
|
255,187,992 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/ANDESCON56260.2022.9989526",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This paper proposes and evaluates an electrical and thermal dynamic model to simulate the effect of voltage unbalance in the parameterization of digital protection of the large induction motors. Based on space vectors, the electrical model has variable parameters with temperature, skin effect and saturation. The thermal capacitances and conductance of the thermal model are identified from the MATLAB Simulink parameter estimation tool. The 1.8 MW motor of the feedwater pump of a power plant is evaluated. The errors concerning the stable state temperatures of the manufacturer’s heating test are 1.1 °C for the stator and 0.56 °C for the frame. The temperature increase of the winding during operating cycles with variable load and different unbalanced voltage were simulated and compared with the thermal image of the relay, demonstrating the importance of these tests in the protection adjustment.
|
2022-12-30T18:34:41.025Z
|
244,674,360 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.14746/seg.2018.17.17",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "https://pressto.amu.edu.pl/index.php/seg/article/download/30042/26602"
}
|
The author of the article discusses in depth ten works of art (prints, numismatic pieces, sculptures) which demonstrate iconographic consistency with the obverse or reverse of the said medal. As the author argues, the medallionist sought both to reflect current events in Cracow and commemorate the beginning of the propitious reign of Jan III Sobieski and Maria Kazimiera, which would benefit the people of the Commonwealth (bear fruits), which is why he used well-known representations from 17th-century compendia of emblems as well as 16th- and 17th-century coinage and medals.
|
2022-01-27T14:26:29.887Z
|
19,837,061 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1371/journal.pone.0188115",
"MAG": "2769808266",
"PubMedCentral": "5687720"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0188115&type=printable"
}
|
Standard open and percutaneous minimally invasive surgical procedures co-exist in the treatment of fractures of the thoracolumbar spine. Shorter skin incisions just above the pedicles are used in minimally invasive procedures. Full-length skin incisions and invasive preparations are applied in the standard open approach. While both methods show equivalent rates of intraoperative surgical complications and comparable clinical and radiological outcomes, blood loss and operation time have shown to be decreased in minimally invasive treatment. However, no study so far has investigated differences in microcirculation. This study hypothesized less impairment of microcirculation in the minimally invasive approach compared to the open approach and an improvement of microcirculation over time. A prospective cohort study was conducted using non-invasive laser-Doppler spectrophotometry (an O2C “oxygen to see” device) for measurement of cutaneous and subcutaneous blood oxygenation (SO2), haemoglobin concentration (Hb), and blood flow at depths of 2, 8, and 15 mm at six locations on the skin. Measurements were performed before surgery, 8 and 24 h after surgery, and 2, 4, 7, 12 and 20 days after surgery, however the number of patients measured decreased towards the later time points. Forty patients were included in the study, 20 with each approach (18 females and 22 males). Pair-wise comparison of the types of surgical procedure for each measurement point revealed a significantly higher flow value in the minimally invasive group at one of the measurement points located between the incisions (P = .041). The point-wise analyses of SO2 and Hb did not show significant differences between the approaches. In conclusion, significantly albeit moderately higher flow values could be found in minimally invasive procedures compared to open operations of thoracolumbar fractures in the area of skin that is spared by the incisions.
|
2022-09-09T22:43:27.809Z
|
19,441,114 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1177/019459988309100316",
"MAG": "2204137899",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Facial electroneurography is an objective electrophysiologic measurement of a muscle compound action potential used to assess prognosis for recovery from facial paralysis. In the present study, test precision is accompanied by a test-retest variability of 6.2%. The primary source of this variability is trigeminal nerve artifact, but submaximal nerve stimulation, changing skin resistance, and inherent nerve properties may also influence results. An ideal stimulus intensity that avoids patient discomfort and trigeminal nerve artifact but attains maximal nerve response is not possible in every patient.
|
2022-09-13T04:42:09.282Z
|
8,227,123 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1071/EN14097",
"MAG": "2155308373",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Environmental context Water-soluble dicarboxylic acids and related compounds are ubiquitous in atmospheric aerosols. They are abundantly emitted from Asian countries and transported to the Pacific Ocean. During the long-range transport, photochemical processing modifies organic aerosols. We conducted a 1-year observation of diacids and related compounds at Okinawa Island, an outflow region of the Asian Continent, to clarify their sources and photochemical aging. Abstract Ambient aerosol samples were collected for 1 year at Okinawa Island, Japan, and were analysed for water-soluble dicarboxylic acids, oxoacids, α-dicarbonyls and fatty acids to better understand biogenic v. anthropogenic sources and the formation–transformation of organic aerosols during long-range atmospheric transport. Here, we report seasonal variations of diacids and related compounds in Okinawa. We found a predominance of oxalic acid (C2) followed by malonic (C3) and succinic (C4) acid. Total diacids and oxoacids maximised in spring when air masses originated from the Asian Continent with westerly winds. In contrast, phthalic acid (Ph), a tracer of anthropogenic sources, peaked in winter. We found an increased C3/C4 ratio in summer, suggesting an enhanced photochemical aging of organic aerosols. The average ratio of total diacid-C/total carbon (TC) (5.4%) is higher than that (3.1%) from the East China Sea, suggesting that Okinawa aerosols are more aged than East Asian aerosols but less aged compared to those from the remote Pacific including tropics (8.8%). Biogenic short-chain fatty acids and azelaic acid (C9), the latter is a specific oxidation product of unsaturated fatty acids, maximised in summer, whereas higher plant-derived long-chain fatty acids maximised in spring. This study demonstrates that the ambient aerosols in Okinawa are strongly influenced by the Asian outflow in winter and spring and by biogenic organic matter in summer and spring. Enhanced contribution of oxalic acid to aerosol TC in spring suggests that Okinawa organic aerosols are mainly produced in East Asia and photochemically transformed during the transport.
|
2022-09-15T22:15:50.559Z
|
201,664,595 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1128/JCM.00961-19",
"MAG": "2971013443",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Methicillin (β-lactam) resistance in Staphylococcus epidermidis is mediated by the mecA gene, with resistance reported to be as high as 90%. The goal of this study was to evaluate oxacillin and cefoxitin disk diffusion (DD) and broth microdilution (BMD) methods for the detection of mecA-mediated β-lactam resistance in 100 human isolates of S. epidermidis (48 mecA-positive isolates and 52 mecA negative isolates). ABSTRACT Methicillin (β-lactam) resistance in Staphylococcus epidermidis is mediated by the mecA gene, with resistance reported to be as high as 90%. The goal of this study was to evaluate oxacillin and cefoxitin disk diffusion (DD) and broth microdilution (BMD) methods for the detection of mecA-mediated β-lactam resistance in 100 human isolates of S. epidermidis (48 mecA-positive isolates and 52 mecA negative isolates). Oxacillin DD tests using the Clinical and Laboratory Standards Institute (CLSI) M100-S28 breakpoints for S. pseudintermedius/S. schleiferi accurately differentiated mecA-positive and -negative S. epidermidis isolates, with categorical agreement (CA) of 100% and no very major errors (VMEs) or major errors (MEs) identified. Likewise, oxacillin BMD and cefoxitin DD tests using the coagulase-negative Staphylococcus species (CoNS) breakpoints were highly reliable for detecting mecA-mediated β-lactam resistance in S. epidermidis isolates. For cefoxitin DD and BMD results interpreted using S. aureus/S. lugdunensis breakpoints, the CA was 97.6% and 96.2%, respectively. There were 4.9% VMEs for cefoxitin DD with 0% MEs, and 3.6% VMEs and 3.9% MEs for cefoxitin BMD. Oxacillin BMD using S. aureus/S. lugdunensis breakpoints yielded the highest VMEs at 17.4% and 90% CA. Our findings demonstrate that oxacillin DD tests using the CLSI M100-S28 breakpoints for S. pseudintermedius/S. schleiferi and oxacillin BMD and cefoxitin DD tests using the CoNS breakpoints reliably identified mecA-mediated β-lactam resistance in S. epidermidis. Using mecA PCR as the gold standard, the PBP2a SA culture colony test (Abbott Diagnostics) exhibited 100% sensitivity and specificity whereas 2 false negatives were identified using the PBP2ʹ latex agglutination test kit (Thermo Fisher Scientific) with sensitivity and specificity of 95.8% and 100%, respectively.
|
2022-12-15T09:25:23.158Z
|
153,995,478 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/21647259.2015.1094907",
"MAG": "1952782792",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Abstract This article examines the contemporary interconnections between the politics of peacebuilding and the politics of counterinsurgent warfare in Somalia. Differing from much of the existing critical literature on Somalia that emphasises problems associated with top-down orthodox stabilisation approaches, this article explores the trajectories of counterinsurgent warfare that places ‘the local’ at the centre of intervention and work on logics of ‘small footprints’, hybridity and complexity. Here, it is no longer primarily the state and its institutions but the population and the everyday of ‘the local’, in and of itself, which constitutes the key object for counterinsurgency interventions, and as such the new main battle space in which insurgencies are to be defeated. In the context of these human-centred approaches to overcoming ‘subversion’, the means and ends of peacebuilding and those of ‘everyday warfare’ are becoming increasingly blurred.
|
2022-12-17T13:20:02.495Z
|
24,403,734 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/jso.23415",
"MAG": "1925586661",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
MicroRNAs (miRNAs) are small, noncoding RNAs that are involved in carcinogenesis through postranscriptional gene regulatory activity. Few studies have focused on the detection of miR‐21 in serum rather than in tissue. The current study aimed to measure serum miR‐21 expression levels and to evaluate their association with the outcome of colorectal cancer (CRC).
|
2022-12-18T22:31:28.627Z
|
12,264,190 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1090/S0002-9947-01-02832-X",
"MAG": "1867191164",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Let D be a bounded symmetric domain in a complex vector space VC with a real form V and D = D∩V = G/K be the real bounded symmetric domain in the real vector space V . We construct the Berezin kernel and consider the Berezin transform on the L2-space on D. The corresponding representation of G is then unitarily equivalent to the restriction to G of a scalar holomorphic discrete series of holomorphic functions on D and is also called the canonical representation. We find the spectral symbol of the Berezin transform under the irreducible decomposition of the L2-space. Introduction The main purpose of the present paper is to calculate the spectral symbol of the Berezin transform on real bounded symmetric domains. To explain our results and motivations we let D be the unit disk in the complex plane with the Lebesgue measure dm(z). We consider the weighted Bergman space H (ν > 1) of holomorphic functions on D square integrable with respect to the measure (1 − |z|2)ν−2dm(z). It has up to some positive constant the reproducing kernel Kw(z) = K(z, w) = (1 − zw)−ν . Moreover the group Gc = SU(1, 1) of fractional transformations of D acts on the space H via f(z) 7→ f(gz)g′(z) ν2 and it forms an irreducible unitary (projective) representation. Consider the subgroup SO(1, 1) consisting of transformations of the form z 7→ az+b bz+a with a, b ∈ R and a − b = 1. Thus it is of interest to study the irreducible decomposition of the weighted Bergman space under the subgroup G = SO(1, 1). For that purpose we consider the unit interval D = D ∩ R = (−1, 1) as a trivial symmetric space G/K = SO(1, 1)/{±1} and the restriction of holomorphic functions in H to the interval D. More precisely, consider R : H → C∞(D), Rf(x) = f(x)(1 − x) ν2 , x ∈ D. Let L(D, dμ0) be the L space on D with the SO(1, 1)-invariant measure dμ0(x) = dx (1−x2) , whose decomposition under SO(1, 1) can be done via the Mellin transform (see below). The restriction R is a bounded operator from H into the space L(D, dμ0) with dense image, and intertwines the respective actions of SO(1, 1), Received by the editors January 16, 2000 and, in revised form, October 10, 2000. 2000 Mathematics Subject Classification. Primary 22E46, 43A85, 32M15, 53C35.
|
2022-12-20T19:40:35.224Z
|
29,878,833 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1128/MCB.00856-13",
"MAG": "2164845040",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
ABSTRACT Mutation in CYP1B1 has been reported for patients with congenital glaucoma. However, the underlying mechanisms remain unknown. Here we show increased diurnal intraocular pressure (IOP) in Cyp1b1-deficient (Cyp1b1−/−) mice. Cyp1b1−/− mice presented ultrastructural irregular collagen distribution in their trabecular meshwork (TM) tissue along with increased oxidative stress and decreased levels of periostin (Postn). Increased levels of oxidative stress and decreased levels of Postn were also detected in human glaucomatous TM tissues. Furthermore, Postn-deficient mice exhibited TM tissue ultrastructural abnormalities similar to those of Cyp1b1−/− mice. Administration of the antioxidant N-acetylcysteine (NAC) restored structural abnormality of TM tissue in Cyp1b1−/− mice. In addition, TM cells prepared from Cyp1b1−/− mice exhibited increased oxidative stress, altered adhesion, and decreased levels of Postn. These aberrant cellular responses were reversed in the presence of NAC or by restoration of Cyp1b1 expression. Cyp1b1 knockdown or inhibition of CYP1B1 activity in Cyp1b1+/+ TM cells resulted in a Cyp1b1−/− phenotype. Thus, metabolic activity of CYP1B1 contributes to oxidative homeostasis and ultrastructural organization and function of TM tissue through modulation of Postn expression.
|
2022-12-23T02:18:57.740Z
|
187,898,992 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1177/002205746815000402",
"MAG": "2885695575",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A. Formation of the School of Education 1. Teacher education at the College of Liberal Arts: 1904-1918. Teacher education at Boston University originated in the College of Liberal Arts under the initiative of William Marshall Warren. He made significant contributions to the progress of teacher education at Boston University when he became Dean of the College of Liberal Arts. His first report to the President, covering the 1904-1905 academic year, contained two proposals: (a) that the College of Liberal Arts establish a Department of Education for students intending to teach in the public schools, particularly those in Boston; and (b) that the College offer late afternoon and Saturday courses for inservice teachers:
|
2022-01-24T19:31:16.168Z
|
218,827,128 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.30762/itr.v3i1.2036",
"MAG": "3016574961",
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
This community service program is a form of campus academic activities to help overcome the economic problems of rural communities, especially village women who in fact in terms of the economy are less productive. The main aim of this program is to increase the economic potential of village women based on Majlis Ta'lim. This is done to face the challenges for Small and Medium Enterprises (UKM) to increase competitiveness through increasing productivity and quality of products according to the Indonesian National Standard (SNI), especially for rural home industries, especially women farm laborers to use their time optimally to improve family welfare. They not only rely on rice fields (tandur) and the harvest period, which is approximately three months' waiting period. They not only depend on the natural and environmental conditions that exist, but also are able to take advantage of the existing potential to make a more economic contribution to the household. With the ABCD method, the companion made a change of mindset while conducting marketing strategy training on the production of crackers which had been carried out by several members of the Ta'lim Assembly, by providing training in marketing strategies with product targets, distribution, pricing, and promotion strategies that had followed developments ( on line marketing), so that the selling power increases. Paying attention to the SWOT analysis, namely strengths, weaknesses, opportunities, and threats can generally be overcome because the people in Bakalan Village, Grogol Subdistrict, Kediri Regency, especially Majlis Ta'lim Muslimah have a strong and maintained network of friendship through routine recitation, so that this economic activity remains can be done. Keyword : ABCD, Majlis Ta’lim, Marketing Strategy, Crackers
|
2022-02-08T01:43:46.038Z
|
68,145,840 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4081/RR.2009.E7",
"MAG": "2135785856",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A 56-year-old woman was admitted to the rheumatology clinic with symptoms of burning and the feeling of grit or sand in her eyes. She also had dryness of the mouth, giving rise to difficulties with speech and swallowing food. The presence of anti-Ro/SSA and anti-La/SSB autoantibodies, and grade 4 chronic lymphocytic sialadenitis on biopsy of the salivary gland, together with the clinical findings revealed Sjögren’s syndrome. The patient was referred to the dermatology clinic because of widespread depigmentation in the middle of her back (Figure 1). Following the dermatological examination, the patient was considered to have vitiligo. With the help of Wood’s light examination, the diagnosis was confirmed. Another remarkable dermatological finding was violaceous-colored, slightly depressed and atrophic oval plaques of variable size (10x10 cm to 7x8 cm) on the abdominal and gluteal regions (Figure 2). Histopathological examination of these lesions demonstrated morphea. The patient was unaware of these dermatological conditions. In her past history, the patient had received radioactive iodine therapy for an adenoma of the thyroid gland eight years ago. In the family history, her daughter had been diagnosed with rheumatoid arthritis. Systemic examination of the patient was unremarkable. There was no systemic involvement associated with the morphea and Sjögren’s syndrome. Laboratory findings for a complete blood cell count, vitamin B12 levels, biochemical analysis, and urinalysis were normal. However, on admission abnormal laboratory findings included: erythrocyte sedimentation rate, 30 mm/hour (normal range, 0-20 mm/hr); C-reactive protein, 3 mg/L (0-5 mg/L); rheumatoid factor (RF), 604 IU/ml (0-15 IU/mL); and antinuclear antibody (ANA), 1/320 granular pattern. While anti-Ro/SSA and anti-La/SSB antibodies were positive, anti-double-stranded DNA (anti-dsDNA), and anti-centromere antibody were negative. A biopsy of the salivary gland revealed grade 4 chronic lymphocytic sialadenitis based on the Chilsom classification. Schirmer’s tear test was used for the evaluation of tear secretion by the lacrimal glands. There was wetting of less than 5 mm per 5 min. This demonstrated a strong indication of diminished secretion. Autoimmune etiology is thought to play a role in these diseases. Sjögren’s syndrome is an autoimmune disorder with a higher female incidence, distinctive human leukocyte antigen (HLA) associations, familial clustering with other autoimmune processes, and the presence of autoantibodies, such as antiRo/SSA and anti-La/SSB antibodies. The association of vitiligo with autoimmune diseases has suggested an immunological basis for vitiligo. Involvement of humoral immunity was first demonstrated by the finding of circulating antibodies directed to melanocytes. The vitiligo antibodies are attracted predominantly to various melanocyte antigens, including tyrosinase, tyrosinase-related protein 1, and tyrosinase-related protein 2. Recently, autoantibodies to a transcription factor called S0X10 have been found in vitiligo related to polyglandular dysfunction. Some studies have indicated an association of autoimmune diseases with morphea. In addition to positive titers of ANA, antidsDNA, and anti-scleroderma (-Scl) 70 antibodies, increased RF levels suggest that an immunological process occurring in morphea. Although Sjögren’s syndrome, vitiligo, and morphea are autoimmune diseases, they are seen together rarely. A few studies have reportCorrespondence: Sema Yilmaz, Vatan cad. Devrim sitesi B/Blok No: 25/4, 42040 Selcuklu, Konya, Turkey. E-mail: drsemayilmaz@hotmail.com/ drsemayilmaznew@gmail.com
|
2022-02-11T12:25:39.624Z
|
162,496,570 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5944/ETFIII.13.2000.3647",
"MAG": "2161563643",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
En la primavera del ano de 1489 el obispo de Caianla, don Alonso Carrillo de Albornoz se establece en Santiago de Compostela. Llega como delegado del obispo de Avila, fray Hernando de Talavera, quien iunto con otros eclesasticos habia sido designado por Inocencio VIII — a instancias de los Reyes Catolicos— para acometer la reforma eclesiastica en Galicia. Su mision consiste en recabar una informacion fidedigna de la situacion eclesiastica y por tanto tambien de uno de sus mas graves problemas: las intromisiones de los laicos en los asuntos eclesiasticos. Un resultado directo de esta mision se conserva en el obispado de Curense, al realizarse alli en ese mismo ano de 1489, un «memorial, tumbo e inventario» que recoge diversa informacion sobre los beneficios y prestamos de toda la diocesis. During the spring of 1489, the Bishop of Caianla, don Alonso Carrillo de Albornoz setiled down in Santiago de Composiela. He arrived as a delegale ofttie Bishop of Avila, fray Hernando de Talavera who, together with other ecclesiastics, had been appointed by the Pope Innocent VIIF —by suggestion of the Catholic Kings— to develop the ecclesiastic reform in Galicia. His mission was to gather reliable Information about the ecclesiastic situation and thus, about one of its most serious problems: the intromissions of the laymen in the ecclesiastics affairs. One of the direct results of that mission is preserved in the bishopric of Curense, where during that year of 1489, was written a «memorial, tumbo and inventory» with some Information about benefices and «prestamos» of all the diocesis.
|
2022-07-04T21:27:53.833Z
|
33,188,960 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3171/2010.3.JNS10155",
"MAG": "2313936438",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
West and colleagues,1 from the Duke University Medical Center and the Durham Veterans Administration Medical Center, point out that although prophylactic fresh-frozen plasma (FFP) transfusion is often administered in hemodynamically stable patients with a minimally elevated international normalized ratio (INR) prior to invasive procedures, there is little evidence to support this practice. This is an important topic, and these investigators have provided us with both a refresher course on the coagulation cascade, and a review of the literature on the use of FFP and other blood products, both as prophylaxis and in patients with acute bleeding. They also present a strong case that the concept of an “abnormal” INR, requiring correction with FFP, needs to be redefined. Partial thromboplastin time (PTT) and prothrombin time (PT) and its normalized ratio (that is, the INR) are clearly useful tests to quantitate the level of factors in the clotting cascade. The evidence that practitioners should attempt to “normalize” the INR in patients who have neither active bleeding, nor a history of a bleeding disorder, simply to reduce the bleeding risk, is limited. Furthermore, attempts at prophylactically correcting the INR may be harmful with regard to the potential for transfusion-related reactions and exposures, volume overload, and the delay attendant to obtaining and administering the FFP. There are many aspects of the coagulation cascade that are unfamiliar to practicing neurosurgeons, and therapy directed to improve hemostasis, although it may seem to be logical on the surface, may be ineffective or even contraindicated. I would recommend that every neurosurgeon carefully read and consider the section of this paper entitled “What should we do when the patient is bleeding?” I found their discussion of what is, in some instances, the almost reflexive use of recombinant activated factor VII (rFVIIa) as an adjunct to FFP administration in patients being treated with coumadin who experience acute bleeding events, to be particularly informative. In general, the authors recommend that prophylactic treatment of an INR of <1.5, in the absence of bleeding, is probably not indicated. Furthermore, they provide a proposed guideline for blood component transfusion (Table 2) that should be considered as part of the decision-making process for the transfusion of blood products by neurosurgeons.
|
2022-09-11T05:17:02.850Z
|
27,890,024 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1093/CLINIDS/3.4.683",
"MAG": "2329124823",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Review of current methods of surveillance for nosocomial infection indicates that prospective surveillance of patients on a daily basis is the most accurate and valid method. In this paper, we detail such a method. Samples of hospitalized patients for surveillance are based on a fixed period of observation in each patient-care area. Data are collected on a detailed, standardized daily log that emphasize the recording of primary clinical data. Such a system is practical and is acceptable to infection control practitioners. Representative samples of patients are obtained. The utility of such a system for identifying preventable risk factors for the development and evaluation of programs of prevention is being tested in 12 acute-care hospitals in Rhode Island.
|
2022-09-12T02:19:07.612Z
|
158,542,287 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1177/1354816617731387",
"MAG": "2757784635",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Business tourism has brought significant benefits to New Zealand’s tourism industry and economy. This study aims to provide a better understanding of the impact of economic uncertainty on New Zealand’s business tourism. The panel data gravity model and the maximally correlated portfolio are used to investigate the impacts of economic policy uncertainty (EPU) indices of New Zealand and its key trading partners, along with tourism and aviation-related factors, on New Zealand’s business tourist flows from 2008 to 2015. The findings suggest that two economic factors (New Zealand’s EPU index and bilateral trade volumes) and two noneconomic factors (flying distance and total direct flight seats) are statistically significant in explaining some of the variations in business tourism flows. The results have important policy implications for New Zealand’s policymakers in understanding business visitor demands and planning their tourism strategies.
|
2022-11-18T15:22:46.260Z
|
206,625,518 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/TC.2012.77",
"MAG": "2033530652",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A complete family of Cayley graphs of degree four, denoted as L-networks, is considered in this paper. L-networks are 2D mesh-based topologies with wrap-around connections. L-networks constitute a graph-based model which englobe many previously proposed 2D interconnection networks. Some of them have been extensively used in the industry as the underlying topology for parallel and distributed computers of different scales. Tori, twisted and doubly twisted tori, toroidal diagonal meshes, chordal rings, and circulant graphs are, among others, members of the L-network family. Therefore, many results obtained in previous studies on these networks can be deduced from the general framework presented in this work. In addition, the network model presented in this work allows for new results on the domain of low-degree interconnection networks. Particularly, closed expressions for the graph distance properties have been derived and an optimal routing algorithm of constant complexity is provided. Since symmetry has a big impact on network performance, we have also identified which L-networks are symmetric by studying their group of automorphisms. Finally, a very simple model that predicts the performance of L-networks is also presented. Such model has been contrasted with empirical evaluation.
|
2022-12-10T08:05:17.794Z
|
225,539,363 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/cpe.5921",
"MAG": "3045035303",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The formation of haze depends on the complex evolution behavior of SO2, NO2, and CO. We explore the influence of surrounding urban oxides on haze formation in Beijing. From the perspective of time evolution, multifractal detrended cross‐correlation analysis (MF‐DCCA) method quantitatively shows that all oxides reveal persistent cross‐correlations (hxy: 0.640 sim; 0.995) in the short term and long term. The correlation characteristics of the same oxide in different regions are compared. In the short term, Zhangjiakou (SO2/NO2) and Tianjin (CO) have the strongest multifractal features, while Zhangjiakou (SO2/NO2/CO) is more prominent in the long term. Their sources are mainly Fat‐tailed. Ignoring the characteristics of timing, the fitting degree (R2) of LightGBM model to PM2.5 concentration regression is 0.862 after the addition of neighboring oxides, an increase of 2.0%. CatBoost's R2 improves by 6.4%. The feature importance score indicates that Langfang's SO2 and Chengde's CO contribute the most to the formation of PM2.5. This study has certain reference value for the formulation of oxide emission strategy in the surrounding area of Beijing.
|
2022-12-13T23:48:02.018Z
|
129,054,610 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1029/96JD00222",
"MAG": "2118238406",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Field, laboratory, and computer modeling methods were utilized to quantitatively assess the capability of aerobic microorganisms to oxidize landfill-derived methane (CH4) in cover soils. The investigated municipal landfill, located in Nashua, New Hampshire, was operating without gas controls of any type at the time of sample collection. Soil samples from locations of CH4 flux to the atmosphere were returned to the laboratory and subjected to incubation experiments to quantify the response of oxidation in these soils to temperature, soil moisture, in situ CH4 mixing ratio, soil depth, and oxygen. The mathematical representations of the observed oxidation reponses were combined with measured and predicted soil characteristics in a computer model to predict the rate of CH4 oxidation in the soils at the locations of the measured fluxes described by Czepiel et al. [this issue]. The estimated whole landfill oxidation rate at the time of the flux measurements in October 1994 was 20%. Local air temperature and precipitation data were then used in conjunction with an existing soil climate model to estimate an annual whole landfill oxidation rate in 1994 of 10%.
|
2022-12-19T05:57:08.834Z
|
9,682,267 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1182/blood-2012-03-378919",
"MAG": "2084877846",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "https://europepmc.org/articles/pmc4916560"
}
|
The progress made in the understanding of chronic myeloid leukemia (CML) since the recognition of a common chromosomal abnormality to the introduction of ever more effective tyrosine kinase inhibitors is unprecedented in cancer. The expected survival for patients diagnosed with CML today, if properly managed, is probably similar to that of the general population. When managing patients with CML the goal is to achieve the best long-term outcome and we should base the treatment decisions on the data available. The results from cytogenetic and molecular analyses have to be interpreted judiciously and all available treatment options integrated into the treatment plan properly. The availability of several treatment options in CML is an asset, but the temptation of rapid succession of treatment changes because of perceived suboptimal response or for adverse events that could be managed needs to be avoided. Any decision to change therapy needs to weigh the expected long-term outcome with the current option versus the true expectations with any new option, particularly as it relates to irreversible outcomes, such as transformation to blast phase and death. In this manuscript, we discuss the treatment approach that has helped us manage successfully a large CML population.
|
2022-12-20T21:11:11.934Z
|
17,274,926 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4108/ICST.PERVASIVEHEALTH2010.8829",
"MAG": "2082950705",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A novel approach to precise and reliable computation of self-selected gait velocity in domestic environments based on the measurements of a laser range scanner is presented. The computation does not require a priori knowledge of the environment. The sensor is part of an ambient assessment system under development which is meant to objectively measure and compare capacity and performance in mobility. Possible application fields may be early detection or differential diagnosis in dementia and assessment of fall risk. Regarding the challenges of future health systems due to the demographic change delaying need of care or preventing falls in dementia can help decrease costs while increasing perceived quality of life for people concerned and their carers. Within this paper we present our theoretic concept and algorithm for computing self-selected gait velocity utilizing measurement from a laser range scanner. Results of an experiment show that the laser range scanner delivers precise measurement and in the future may be used for absolutely unobtrusive analysis of spatio-temporal parameters of gait even in demented people.
|
2022-12-21T14:55:15.810Z
|
61,944,990 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1145/263105.263181",
"MAG": "2145118110",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://dl.acm.org/doi/pdf/10.1145/263109.263181"
}
|
We investigate how FEC (Forward Error Correction) can be combined with ARQ (Automatic Repeat Request) to achieve scalable reliable multicast transmission. We consider the two scenarios where FEC is introduced as a transparent layer underneath a reliable multicast layer that uses ARQ, and where FEC and ARQ are both integrated into a single layer that uses the retransmission of parity data to recover from the loss of original data packets.To evaluate the performance improvements due to FEC, we consider different types of loss behaviors (spatially or temporally correlated loss, homogeneous or heterogeneous loss) and loss rates for up to 106 receivers. Our results show that introducing FEC as a layer below ARQ can improve multicast transmission efficiency and scalability and that there are substantial additional improvements when the two are integrated.
|
2022-12-26T19:00:48.163Z
|
143,104,591 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1300/J076v35n03_08",
"MAG": "1858537515",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
SUMMARY The present investigation is one of the first theoretical studies of young persons entering boot camp. The sample in the present study consists of 326 males, aged 15 to 24 years, in the only boot camp in Arkansas. The purpose of the study is to examine the effects of religiosity within a hypothesized theo retical model with reciprocal relationships of drug use among boot camp in mates. This model is tested with two-stage least squares regression, and all hypothesized relationships, with two exceptions, are supported. The findings show that attachment to caregivers is inversely related to associations with peers who engage in illicit behavior, whereas being abused by an adult is positively related to these associations. These associations have inverse reciprocal relationships with religiosity and secular beliefs, and are positively related to use of excuses for illicit acts, which are positively related to drug use. Drug use in creases with advances in age and among white persons (versus persons of color), and use of drugs has positive reciprocal relationships with selling illicit substances and carrying a gun. Conceptual and practice implications of the study are discussed.
|
2022-08-28T07:03:33.780Z
|
97,763,066 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1039/A706668F",
"MAG": "2055008799",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A variety of synthetic procedures have been employed that allow access to three new tetranuclear [M4(µ3-O)2]8+ (M = MnIII or FeIII) complexes. The complex [Fe4O2Cl2(O2CMe)6(bpy)2] displays an unusual structural asymmetry in its core that can be described as a hybrid of the bent (butterfly) and planar dispositions of four M atoms seen previously in such compounds. Magnetochemical and 57Fe Mossbauer studies on this compound showed that its structural asymmetry has little influence on these properties compared with the more symmetric types. The complex [NBun4][Fe4O2(O2CMe)7(pic)2] has been prepared by an unusual chelate substitution in [NBun4][Fe4O2(O2CMe)7(bpy)2] that does not disrupt the core or the bridging carboxylate groups.
|
2022-09-15T06:30:31.327Z
|
221,055,086 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/00325899.2020.1797293",
"MAG": "3045069805",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
ABSTRACT In this work, Ni49.4Ti50.6 Belleville washers are prepared by metal injection moulding (MIM). The martensitic transition temperatures and service performance of washers were investigated. The thermal hysteresis has reached 63.1–71.6°C, which is much higher than documented data in binary NiTi alloys. Ti2Ni and Ni4Ti3 phase are observed in XRD patterns, which is responsible for the large thermal hysteresis. In the service tests, the restoring forces are higher than 40 kN, which are sufficient to ensure a tight connection of the fasteners. The loop resistance and high-current test have proved the safety of MIM NiTi Belleville washers compared to traditional steel spring washers, which can meet the challenge in complex outdoor circumstances.
|
2022-10-23T16:34:01.226Z
|
94,601,075 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/BBPC.19961000104",
"MAG": "1980529651",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
On increasing concentration in highly diluted aqueous solutions of pseudoisocyanine dyes an intensive absorption band of extremely small half-width (Scheibe band) occurs which is attributed to the formation of dye aggregates (Scheibe or J-aggregates). By polarizing microscopy it is shown that aqueous solutions of pseudoisocyanine diethylchloride at low temperatures and at concentrations c > 0.2wt% become birefringent and exhibit a Schlieren texture characteristic for nematic liquid crystals. Above a certain clearing temperature T C the solution becomes optically isotropic during a discontinuous phase transition as shown by DSC. The Scheibe band vanishes at temperatures some degrees above T C . The phase behaviour is displayed in terms of a T-c diagram. The aggregation numbers have been determined spectroscopically to about 40 to 50 only slightly increasing below T C . Obviously, the Scheibe aggregates exhibit a long-range orientational order even at high dilution typically for a nematic lyotropic liquid crystal. The phase diagram indicates that on increasing temperatures the orientational long-range order vanishes first before the Scheibe aggregates will be thermically decomposed.
|
2022-12-15T00:28:33.552Z
|
20,962,823 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/j.0001-6349.2005.00525.x",
"MAG": "2145781638",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Background. To characterize the potential for adaptive immune protection in cervical mucus plugs with respect to immunoglobulin isotypes and effector cells (phagocytes).
|
2022-12-16T23:25:55.222Z
|
3,458,160 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1021/ACS.JPCC.6B05651",
"MAG": "2477731064",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Hydration structures at crystal surfaces play important roles in crystal growth or dissolution processes in liquid environments. Recently developed two-dimensional (2D) and three-dimensional (3D) force mapping techniques using frequency-modulation atomic force microscopy (FM-AFM) allow us to visualize the hydration structures at the solid–liquid interfaces at angstrom-scale resolution in real space. Up to now, the experimental and theoretical studies on local hydration structures have mainly focused on those on the terrace, but little work has looked at step edges, usually the key areas in dissolution and growth. In this study, we measured local hydration structures on water-soluble alkali halide crystal surfaces by 2D force mapping FM-AFM. The atomic-scale hydration structures observed on the terraces agree well with molecular-dynamics (MD) simulations. We also measured the hydration structures at the step edge of the NaCl(001) surface, which was constantly dissolving and growing, leading to the clear ob...
|
2022-12-17T05:17:29.453Z
|
155,134,157 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2139/SSRN.2421186",
"MAG": "2199964370",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The end of war found Kosovo without essential government institutions and therefore a public security was very fragile. In such a situation, the institution-building of security mechanisms was among the most important steps and priorities in the peace consolidation process. Security is determinant factor in the development and consolidation of democracy and the rule of law. the role of international community in Kosovo has been crucial in ensuring peace and security, but also in creation and consolidation of main institutions and legislation in the security reform through the process known as Security Sector Reform. In this paper, I will present a brief development of the SSR in Kosovo since the war end focusing in the role on international community in this matter.
|
2022-01-27T03:03:30.721Z
|
111,812,626 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3130/aija.79.1891",
"MAG": "2323442776",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://www.jstage.jst.go.jp/article/aija/79/703/79_1891/_pdf"
}
|
In this research, how residential and vocational facilities for the person with physical disabilities adapt new service system of the Services and Supports for Persons with Disabilities Act is studied. The results are as follows: 1) Most of facilities switched their services to the support in residential care and the care for daily life. 2) Some of facilities were originally established as housings for the workers with physical disabilities. 3) The support for persons in residential could not be used with working programs, and some of residents had to quit working. 4) Social inclusion thorough Group homes and Care homes are difficult, because these facilities have to be accessible.
|
2022-05-30T09:33:34.440Z
|
14,296,691 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2478/v10310-012-0020-7",
"MAG": "2059446346",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://content.sciendo.com/downloadpdf/journals/auoc/23/1/article-p121.pdf"
}
|
Abstract The syntheses of new tetraaza macrocyclic compounds of variable ring sizes by non-template methods and their characterization with the help of elemental analysis and spectroscopic techniques (FT-IR, 1H-NMR, and 13C-NMR) have been reported in detail. The vibrational frequencies determined experimentally are compared with those obtained theoretically from density functional theory (DFT) and Hartree-Fock (HF) calculations. The comparisons between the experimental and theoretical results indicate that B3LYP level with both the 3-21G(d) and 6-31G+(d,p) basis sets is able to provide satisfactory results for predicting IR properties. The frontier molecular orbital diagrams and molecular electrostatic potential maps of title compounds have been also calculated and visualized at the B3LYP/6-31G+(d,p) level of theory.
|
2022-03-25T00:54:09.920Z
|
108,494,895 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/NAECON.1997.622756",
"MAG": "1924506232",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
VHF/UHF UWB SAR signal is different from traditional narrow band high frequency SAR in that it has its own special properties. A signal model is derived based on these properties of target and clutter. Several target detectors are available in the literature. A new combined detector is provided which carries on the change detection and the two-parameter CFAR detection in two steps. Our simulation results have shown that the combined detector is simple with significant clutter suppression.
|
2022-07-31T01:12:06.170Z
|
14,823,051 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/j.1467-9361.2009.00509.x",
"MAG": "2107062968",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "https://kops.uni-konstanz.de/bitstream/123456789/11841/1/Can_countries_with_severe_labor_market_frictions_gain_from_globalization.pdf"
}
|
The interaction between increased Southern trade integration (globalization) and labor market frictions is analyzed in a dynamic general-equilibrium North–South nonscale growth model with endogenous Northern innovation and endogenous Southern imitation. The qualitative employment, growth, and relative-wage effects of globalization are shown to depend crucially on the degree of Northern labor market frictions. I demonstrate that only Northern countries with particularly large labor market adjustment costs for both firms and workers benefit from globalization in terms of permanently lower unemployment, temporarily faster growth, and permanently higher wages. This is because of the resulting general-equilibrium feedback effects of Northern labor market frictions that deter Southern imitation incentives. The result does not imply the recommendation to increase Northern labor market rigidities, but it challenges the common belief that labor market flexibility helps Northern countries to better adjust to the “globalization threat” coming from the South.
|
2022-09-14T03:46:07.646Z
|
83,921,706 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/J.1574-6968.1986.TB01221.X",
"MAG": "1966733643",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Respiratory activity of germinating cysts increased markedly during the first 2 h of differentiation whilst the sensitivity of respiration to potassium cyanide (KCN) increased. Similar changes could also be detected in membranes oxidizing NADH. The cytochrome content of cyst membranes exhibited both qualitative and quantitative changes during germination, the most notable being the appearance of cytochrome d at 2 h, the gradual decrease in levels of cytochrome o and the slow rise in the concentration of cytochrome a 1. These modulations in respiratory activity during germination are compared with reports of other processes.
|
2022-12-02T10:43:38.845Z
|
207,017,033 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1021/ic301704f",
"MAG": "2092379207",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "https://europepmc.org/articles/pmc4167049?pdf=render"
}
|
This article describes the synthesis and characterization of several low-spin iron(II) complexes that coordinate hydrazine (N(2)H(4)), hydrazido (N(2)H(3)(-)), and ammonia. The sterically encumbered tris(di-meta-terphenylphosphino)borate ligand, [PhBP(mter)(3)](-), is introduced to provide access to species that cannot be stabilized with the [PhBP(Ph)(3)](-) ligand ([PhBP(R)(3)](-) = PhB(CH(2)PR(2))(3)(-)). Treatment of [PhBP(mter)(3)]FeMe with hydrazine generates the unusual 5-coordinate hydrazido complex [PhBP(mter)(3)]Fe(η(2)-N(2)H(3)) (1), in which the hydrazido serves as an L(2)X-type ligand. Upon coordination of an L-type ligand, the hydrazido shifts to an LX-type ligand, generating [PhBP(mter)(3)]Fe(L)(η(2)-N(2)H(3)) (L = N(2)H(4) (2) or NH(3) (3)). In contrast, treatment of [PhBP(Ph)(3)]FeMe with hydrazine forms the adduct [PhBP(Ph)(3)]Fe(Me)(η(2)-N(2)H(4)) (5). Complex 5 is thermally unstable to methane loss, generating intermediate [PhBP(Ph)(3)]Fe(η(2)-N(2)H(3)), which undergoes bimolecular coupling to produce {[PhBP(Ph)(3)]Fe}(2)(μ-η(1):η(1)-N(2)H(4))(μ-η(2):η(2)-N(2)H(2)). The oxidation of these and related hydrazine and hydrazido species is also presented. For example, oxidation of 1 or 5 with Pb(OAc)(4) results in disproportionation of the N(2)H(x) ligand (x = 3, 4), and formation of [PhBP(R)(3)]Fe(NH(3))(OAc) (R = Ph (9) and mter (11)).
|
2022-12-12T13:21:26.729Z
|
225,457,038 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/08854300.2020.1792181",
"MAG": "3047398685",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In December 1969, the Young Lords captured widespread public attention when they occupied the First Spanish United Methodist Church in East Harlem in order to run their numerous “serve the people” ...
|
2022-12-16T03:16:58.101Z
|
78,394,042 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5604/00114553.1217134",
"MAG": "2512519176",
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
Exposure to blood-borne pathogens such as the human immunodeficiency virus (HIV), hepatitis B virus (HBV) and hepatitis C virus (HCV) is a potentially serious risk to dental care workers. In healthcare settings, blood-borne pathogen transmission occurs predominantly by percutaneous or mucosal exposure of workers to the blood or body fluids (including saliva) of infected patients. Prospective studies of healthcare workers have estimated that the average risk of HIV, HCV and HBV transmission after a percutaneous exposure to blood of an infectious patient, without postexposure prophylaxis (PEP) for HIV or without prior Hepatitis B vaccination and evidence of protective antibodies, is approximately 0.3% (HIV), 1.8% (HCV) and 6-30% (HBV).
|
2022-02-11T04:46:35.370Z
|
123,415,576 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1121/1.2029294",
"MAG": "2082434334",
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
This work was part of a project whose long‐range goal is the development of a device for estimating the size of bubbles in human tissue. Calibration standards are expected to consist of gas bubbles in polymer gels. Accordingly, equations in Prosperetti [J. Acoust. Soc. Am. 56, 878–885 (1974)] that describe forced oscillations of a gas bubble in a liquid have been modified to apply to the case of a gas bubble in a linearly elastic solid. The changes in the analytic expressions for the resonance solutions are modest, and the major features are preserved (e.g., hysteresis for main, subharmonic, and harmonic frequency regions). More precise equations for the liquid case in Kamath and Prosperetti [J. Acoust. Soc. Am. 85, 1538–1548 (1989)] have also been modified to treat the elastic solid case. Following these authors, a Galerkin spectral method was used to generate numerical solutions to the governing partial differential equations. Situations in which two or more stable solutions exist for a given set of par...
|
2022-05-20T06:11:11.513Z
|
142,640,179 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/0471264385.WEI1123",
"MAG": "1561657999",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The chapter begins with an historical review of the development of sexually violent predator (SVP) statutes and the judicial response culminating with the U. S. Supreme Court decision in Kansas v. Hendricks. Specifics of this ruling, established “mental abnormality or personality disorder,” rather than the more familiar mental illness or mental disease, as a constitutionally acceptable basis for civil commitment. However, the Court further indicated that the particular abnormality must impair the individual's behavioral control, making psychodiagnostics in this context challenging. Principles of risk assessment are discussed as they are applied to sexual offenders. Special problems in this arena of risk assessment include the inherent difficulty of establishing a reasonable base rate, the lack of consistent definition of such basic terms as “sexual offense,” and the innate heterogeneity of this population. A number of psychometric and actuarial instruments recently developed to assist in conducting SVP risk assessments are compared. Risk management strategies are then explored, and the efficacy of a variety of approaches is discussed. Although many studies evaluating the effectiveness of sex offender treatment have been published, deficits in research methodology have left us without a definitive answer as to what will reduce recidivism in this population. The chapter concludes with a discussion of the professional and ethical issues confronting the forensic psychologist presenting testimony to the court regarding sexual predators.
Keywords:
forensic assessment instruments;
Kansas v. Hendricks;
risk assessment;
sex offender recidivism;
sex offender treatment;
sexual predator
|
2022-09-13T22:42:49.333Z
|
253,132,947 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.24060/2076-3093-2022-12-3-250-255",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.surgonco.ru/jour/article/download/722/513"
}
|
Introduction. Sarcomas refer to a group of heterogeneous non-epithelial malignant tumors originating from connective tissue. These tumors are characterized by extremely aggressive local growth, relatively low incidence of lymphogenic metastases, predominant and early hematogenic generalization. These tumors most oft en metastasize to the lungs.Materials and methods. The paper describes a case of successful surgical treatment for a giant retroperitoneal fibrosarcoma metastasis to the lung.Results. Successful treatment for sarcoma depends primarily on a global understanding by oncologists of the complex pathogenesis, histological forms and principles of comprehensive treatment for this complex, polymorphic group of malignant pathologies. The earlier the primary site is diagnosed, the sooner and more definitely the surgical treatment is performed, and the more correctly the drug therapy is carried out, the better the result of the complex treatment approach. Similarly, sarcoma secondary sites should be treated proactively – without waiting until their size and local spread contraindicate surgical treatment. Conclusion. Neglected sarcoma cases indicate the need for combined and extended surgical interventions, one successful example of which is described in this paper.
|
2022-11-11T07:40:09.615Z
|
25,239,693 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/ISQED.2008.51",
"MAG": "2111996802",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
With the advent of ultra deep-submicron (UDSM) regime of integrated circuits, the issues with circuit marginality related transient failures are on the rise. An example of such failures is the thermal hotspot-induced ones, which are common when a particular functional unit experiences high switching activity for a considerable duration. In this paper, we propose an on-line hotspot-induced transient failure testing scheme using the built-in self-test (BlST)-based approach which accurately distinguishes such a transient failure from a hard fail and greatly reduces the test cost by dissociating a tester from the test process. We apply the principle of Fmax testing based on frequency shmoo to obtain the maximum safe operating frequency for individual functional units in a chip. We also propose a DFT scheme to characterize the impact of a "hot" unit on its neighborhood and also the influence of a "hot" neighborhood on an otherwise "cold" unit in the reverse way. Thus the proposed architecture extends the capability of the conventional BIST to test a certain class of circuit marginality related transient failures with a very low hardware overhead.
|
2022-12-17T09:59:35.048Z
|
195,798,937 |
{
"externalids": {
"ACL": null,
"ArXiv": "1907.02102",
"DOI": "10.1145/3343036.3343129",
"MAG": "2955736529",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://dl.acm.org/doi/pdf/10.1145/3343036.3343129"
}
|
We present a novel, real-time algorithm, EVA, for generating virtual agents with various perceived emotions. Our approach is based on using Expressive Features of gaze and gait to convey emotions corresponding to happy, sad, angry, or neutral. We precompute a data-driven mapping between gaits and their perceived emotions. EVA uses this gait emotion association at runtime to generate appropriate walking styles in terms of gaits and gaze. Using the EVA algorithm, we can simulate gaits and gazing behaviors of hundreds of virtual agents in real-time with known emotional characteristics. We have evaluated the benefits in different multi-agent VR simulation environments. Our studies suggest that the use of expressive features corresponding to gait and gaze can considerably increase the sense of presence in scenarios with multiple virtual agents.
|
2022-12-13T11:28:09.391Z
|
131,699,039 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.18597/RCOG.303",
"MAG": "2138460924",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
SUMMARY INTRODUCTION: Sexual harassment is an asymmetric kind of violence; it shows the asymmetries in the relation- ships between genders, which is characteristic of the patriarchal culture. This thematic has not much investigation in the university environment but has great repercussions for the victim. MATERIALS AND METHODS: In this cross- sectional study a survey was used for the recollection of data using 205 students if the University of Manizales, Manizales (Colombia). The sample size was calculated based on a population of 3584 students. RESULTS: During stay at the university a frequency of 6.8% of sexual harassment was found, this was found only in the first 4 seme- sters, mostly which were propitiated by teachers (50%), 21.4% caused by classmates (male and female in same proportion). The impacts generated by the event were the entire great amount of options given in the survey (11.8%). Only 7.1% made a claim, and of those only 66.7% obtained any help. 47.1% has been victim of blackmail and intimidation to keep them from making a claim. 29.4% of the harassed were under the influence of psychoac- tive substances. 23.5% consider that they (in part) propitiated the harassment. CONCLUSIONS: Sexual harassment is an assault on fundamental rights, which also exists at the University of Manizales, although compared with other studies the frequency isn't as high, it becomes a problem one should intervene.
|
2022-12-20T22:07:55.624Z
|
234,375,186 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/14794713.2020.1864712",
"MAG": "3113678227",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "https://halshs.archives-ouvertes.fr/halshs-03082745/file/2020_Boutard%20%26%20Fe%CC%81ron%20-%20Documenting%20acousmatic%20interpretation%20%28IJPADM%2017-3%2C%202021%29.pdf"
}
|
ABSTRACT The investigation of acousmatic music interpretation as a distinct activity from composition calls for the investigation of appropriate documentation frameworks. This paper investigates the relevance of cross self-confrontations to capture all dimensions of interpretation of acousmatic music from a dialogical and developmental perspective. This study is the second phase of the project Interpretation Spatiale des Musiques Electroacoustiques (ISME), following a theoretical investigation of acousmatic music interpretation. It is based on the automated re-enactment of several performances conducted during an acousmatic interpretation workshop and masterclass at LaBRI-SCRIME in 2015. The analysis presents the practical and theoretical relevance of the framework in relation to the dimensions of acousmatic interpretations conceptualized during the first phase of the project based on semi-structured interviews.
|
2022-12-23T02:19:14.991Z
|
220,235,612 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1136/bmj.2.2609.2036",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
THE relation between parasitic worms and anaemia is one which has engaged considerable attention, both clinically and experimentally. Many' of these worms induce changes in the blood-for example, eosinophilia -without causing obvious symptoms of anaemia. As far as observations go, eosinophilia seems to be much more frequently associated with the presence of nematode worms than with tapeworms or flukes, and there is no doubt that it is an almost constant symptom of miner's worm anaemia, due to AnkyZostoma duodenale. So constant, indeed, is it in this disease and to such an extent does its degree indicate the severity of infection, that it has been recommended by Boycott as the most important diagnostic sign, next to the presence of ova in the faeces, in endemic areas. The explanation of the phenomenon of eosinophilia, as well as the other blood changes due to parasitic worms, is still quite obscure. Many are the attempts that have been made and varied the methods employed to probe the mystery, but the measure of success has not been great. A suggestion not infrequently made is that in the case of " biting" worms, such as Ankylostoma, the anaemia is mainly due to continued small losses of blood. Possible enough as this may be, it is not supported by experimental evidence, and it is far from explaining the blood condition. In the case of tapeworms it is entirely inapplicable. No loss of blood occurs in " BothriocephaZus anaemia," and yet Dibothriocephalus latus is accredited with the production of one of the most profound forms of anaemia. This fact has led to search for a cause in other directions, and has naturally strengthened the present toxic theory of the etiology of the graver anaemias. It is evident that it Dibothriocephalus and Ankylostomna are to be regarded as the cause, direct or indirect, of the anaemias with which they are associated, some link must be found connecting the worm with the blood condition. The fact that certain toxic substances when injected into the blood can give rise to profound anaemia, and the demonstration that analogous substances can be isolated from the bodies of the parasites establish this link. In the case of DTbothriocephalus latus, which from its bulk is more suited for experimental work than the small Ankylostoma, Tallqvist has definitely shown that such substances are present in the tissues of the tapeworm. By suitable means they can be extracted and their nature to some extent determined. Amonget them are found a haemolysin and a haemagglutinin, which act not only in vitro, but also when injected into a normal animal. By such injection Tallqvist was able to reproduce an anaemic condition resembliDg to some extent true Bothriocephalus auaemia. The haemolysin iq of a lipoid nature, and substances of this kind can be extracted from various normal organs of the body, in particular the intestiaal mucosa, as well as from certain malignant neoplasms. The theory is, therefore, very tempting that the anaemia is the direct result of the absorption of these substances by the blood. Under what conditions they are absorbed and in what manner is still a matter of great doubt. It is of some significance, in support of this view, that no other human tapeworm is known to give rise to anaemia of a pernicious type, and that repeated attempts have failed to isolate from these a haemotoxic substance in demonstrable quaBntity. The case of Ankylostoma anaemia is somewhatc different. The anaemia is of a different type, resembling more closely the hydraemia of chlorosis. That the condition is actually hydraemic has been demonstrated by Haldane in one case. The occurrence of repeated small haemorrhages is, as already mentioned, not without some importance in the etiology, but attempts have not been wanting to ascertain the existence in Ankylostoma of haemotoxic substances resembling those found in Dibothriocephalus. The difficulties in this direction are somewhat great, for a, large amount of material is necessary for a continued series of experiments. More than one observer, however, has stated that a haemolytic substance can be extracted from the tissues of Ankylostoma. On the other hand, the latest contribution to the isubject by Loeb and Fleischer1 contains a direet negative statement on this point. Using worms which had been dried and ground to powder, these workers were quite unable to detect the presence of any direct haemolytic substance, or of any substance which could be activated by combination with lecithin. At the same time they were able to isolate from the anterior end of the worm a substance possessing a remarkable power of inhibiting coagulation of blood; the substance is extremely stable, ond is not destroyed by boiling nor by being preserved in a dried condition. It behaves very much like an analogous auticoagulin obtained by Weinberg from the sclerostome of the horse, but it appears to be of quite a different nature from the corresponding substance in the leech. The authors draw a further interesting comparison between it and the anticoagulating principle in cobra venom. In how far it is to be regarded as effecting the blood changes of Ankylostoma anaemia does not appear, and to determine this point much further work is necessaryb
|
2022-01-27T02:39:46.217Z
|
219,847,945 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.22051/JWSPS.2020.27308.2045",
"MAG": "3024630213",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
پژوهش حاضر باهدف بررسی سهم خودکارآمدی و هیجان خواهی در پیشبینی اعتیاد به اینترنت انجام گرفت. پژوهش توصیفی از نوع همبستگی بود. جامعه آماری را دختران دانشآموز پایه دوم و سوم دوره دوم متوسطه تشکیل میداد که در سال تحصیلی 95-1394 در مدارس دولتی منطقه 8 تهران به تحصیل اشتغال داشتند.240 نفر به روش نمونهگیری تصادفی چند مرحلهای انتخاب شدند. پرسشنامههای خودکارآمدی عمومی شرر و همکاران، هیجان خواهی زاکرمن و اعتیاد به اینترنت یانگ اجرا شد. نتایج تحلیل دادهها با روش همبستگی پیرسون و رگرسیون چند متغیری سلسلهمراتبی نشان داد که خودکارآمدی و هیجان خواهی می توانند اعتیاد به اینترنت را در گروه نمونه پیش بینی می کنند.همچنین یافته های نشان داد بین خودکارآمدی با اعتیاد به اینترنت همبستگی منفی و معنادار؛ و بین مؤلفههای هیجان خواهی با اعتیاد به اینترنت همبستگی مثبت و معناداری وجود داردواز چهار مؤلفه هیجان خواهی تنها مؤلفه ماجراجویی به صورت مثبت و معنادار اعتیاد به اینترنت را پیشبینی میکند. بنابراین، می توان گفت با توجه به اهمیت استفاده از اینترنت در زندگی امروز و در نظر گرفتن سهم هر یک از متغیرهای خودکارآمدی و هیجان خواهی درپیش بینی اعتیاد به اینترنت می توان برای استفاده مناسب از اینترنت،طرح ریزی های دقیق انجام داد.
|
2022-01-27T08:56:59.123Z
|
240,368,365 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.17851/2358-9787.27.1.119-136",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "https://doi.org/10.17851/2358-9787.27.1.119-136"
}
|
Resumo: Ainda que não contenha um número abundante de cartas, a correspondência entre Mário de Andrade, então diretor do Departamento de Cultura, e Graco Silveira, então professor da Escola Normal Complementar de Itapetininga, apresenta nexos que revelam um diálogo em torno da língua nacional, das variantes linguísticas e do folclore do interior do estado de São Paulo. Este artigo busca, por meio da leitura dessa correspondência e de artigos publicados em periódicos, como O Estado de S. Paulo e Revista do Arquivo Municipal, reconstituir alguns dos nexos desse diálogo, que surgiu graças ao convite de Mário de Andrade para que Graco Silveira participasse apresentando uma comunicação no Congresso de Língua Nacional Cantada, de 1937, organizado pelo Departamento de Cultura.Palavras-chave: correspondência; Mário de Andrade; Graco Silveira; língua nacional.Abstract: Although there is no abundant number of letters, the correspondence between Mário de Andrade, then director of the São Paulo´s Department of Culture, and Graco Silveira, then professor of the Normal Complementary School of Itapetininga, presents links that reveal a dialogue around the Brazilian´s national language, language variants and folklore of the interior of the state of São Paulo. This article aims to reconstitute some of the nexuses of this dialogue, by comparing the the correspondence with articles published by Graco Silveira in newspapers and magazines, such as O Estado de S. Paulo and Revista do Arquivo Municipal. The dialogue between the two authors started thanks to an invitation by Mario de Andrade to Graco Silveira by presenting a paper at the Congress of National Singing Language (Congresso de Língua Nacional Cantada), which took place in São Paulo in 1937, and was organized by the Department of Culture.Keywords: correspondence; Mário de Andrade; Graco Silveira; national language.
|
2022-02-11T01:14:52.674Z
|
136,647,569 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1116/1.4789445",
"MAG": "1966647226",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "http://publica.fraunhofer.de/bitstreams/e5334250-666b-47ee-b077-9092083c316a/download"
}
|
In this article, the possibilities and limitations of proximity lithography with extreme ultraviolet (EUV) radiation are explored theoretically and experimentally. Utilizing partially coherent EUV radiation with a wavelength of 10.88 nm from a Xe/Ar discharge plasma EUV source, proximity patterning of various nanoantenna arrays has been performed. The experimental results are compared with the results of numerical scalar diffraction simulations, and it is shown that proximity printing in the Fresnel diffraction mode can enable production of high-resolution features even with lower resolution masks, successfully demonstrating sub-30 nm edge resolution in the resist. The potential of the method is explored by simulation of the patterning through circular and triangular apertures as well as through bowtie antenna patterns, with the results suggesting that precise control of the proximity gap and the exposure dose together with simulation-supported mask design optimizations may allow for a wide variety of high-resolution structures to be printed through relatively simple transmission masks. The method is especially suited for high-performance manufacturing of submicrometer sized nanophotonic arrays.
|
2022-07-23T21:38:54.178Z
|
110,512,336 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1299/JSMEC.47.1133",
"MAG": "2053432748",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This paper concerns the minimization of acoustic potential energy in an enclosure by both active noise control (ANC) and active vibration control (AVC). First, the optimal feedforward control law for minimizing the acoustic potential energy in a cavity walled by flexible structures is derived. Secondly, it is found that the control acoustic power radiated from each acoustic secondary source used for ANC and control vibration power infused by each control actuator for AVC become zero under the optimal control condition. It is also found that the zero control power phenomena are the necessary conditions for the optimality. Finally, the control effects for minimizing the potential energy using ANC and AVC are demonstrated from a viewpoint of numerical analysis.
|
2022-09-04T23:50:14.365Z
|
9,824,225 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3109/10731199309117352",
"MAG": "2100070382",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Process parameters using a Microfluidizer M110 to produce liposome-encapsulated hemoglobin (LEH) were further studied to examine their effect on hemoglobin (Hb) encapsulation efficiency (yield), steady shear viscosity, mechanical stability, and oxygen delivery. Liposome formulation loading ratios of up to 300 mumol of lipid per ml of Hb solution were evaluated; a maximum yield was obtained at 300 mumol/ml. Liposomes containing encapsulated Hb concentrations as high as 15.5 g/100 ml were prepared. LEH particle size distribution, determined from negatively stained whole mount preparations using transmission electron microscopy, resulted in average vesicle sizes for optimal batches of about 155 nm. Steady shear viscosity of LEH (up to 40% by volume) in an isotonic-isooncotic solution of PBS containing either albumin or dextran were evaluated for shear rates to 2000 s-1. Values obtained were generally higher than those of whole blood at all shear rates tested. Little leakage of Hb from liposomes stored in isotonic PBS was observed as a function of storage time and shear rate. Administration of LEH supported life in rats whose hematocrit had been reduced via isovolemic exchange transfusion to levels well below 5%, which was incompatible with survival when exchange transfusion was performed with the isotonic-isooncotic PBS solution.
|
2022-09-10T19:51:30.014Z
|
222,113,097 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.21037/JSS-20-587",
"MAG": "3085516550",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Acute postoperative infections after surgical interventions on the spinal column are associated with prolonged treatment duration, poor patient outcomes, and a high socioeconomic burden. In the field of joint replacement, guidelines have been established with recommendations for the diagnosis and treatment of such complications, but in spinal surgery there are no definitions permitting distinction between early and late infections and no specific instructions for their management. Various factors increase the risk of acute postoperative infection, including blood transfusions, leakage of cerebrospinal fluid, urinary tract infection, injury of the dura mater, an American Society of Anesthesiologists (ASA) score >2, obesity, diabetes mellitus, and surgical revision. We suggest defining all infections occurring within the first 4 weeks after spinal surgery as early infections. The symptoms are pain at rest, on motion, and/or pressure pain, abnormal warmth, local erythema, circumscribed swelling of the wound, and newly occurring secretion. Together with laboratory parameters such as C-reactive protein (CRP) and leukocytes, a central role is played by imaging in the form of magnetic resonance imaging (MRI), although diagnosis can be hampered by the presence of postoperative fluid collections such as edema or hematoma or by artifacts from an implant. Once an infection has been confirmed, immediate wound revision with debridement and rinsing (sodium hypochlorite) is essential. Intraoperatively it may prove advantageous to use jet lavage and administer vancomycin. We recommend leaving the implant in place in cases of acute postoperative infection. Patients who are not conditional for surgery can first receive antibiotic suppression treatment before surgery at a later date. In such cases initial computed tomography (CT)-guided aspiration or drain insertion can take place.
|
2022-11-16T18:05:37.742Z
|
16,367,669 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/IJCNN.2012.6252550",
"MAG": "2098083805",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In this paper we present a new hypercomplex-valued model of recurrent neural network which is based on the Geometric Radial Basis (RBF) and Elman Network Models. This model is useful to recognize temporal sequences of geometric entities using geometric algebra. Our model combines features from the Elman recurrent neural network and geometric RBF networks. This network constitutes a generalization of the standard real-valued recurrent models. The network fed with geometric entities can be used in real time to learn a sequence of entities determined using a geometric language. This approach calculates the temporal geometric transformation between each two entity orientations which are presented to the network in different times.
|
2022-02-13T01:14:23.636Z
|
220,327,871 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1128/MRA.00366-20",
"MAG": "3040061831",
"PubMedCentral": "7330233"
},
"license": null,
"status": null,
"url": null
}
|
Here, we report a 29-Mb draft genome sequence of strain 72-15.1 of Simplicillium aogashimaense (Cordycipitaceae, Hypocreales). Strain 72-15.1 was a unique fungal isolate obtained from asymptomatic tillers of the tropical grass Brachiaria brizantha. ABSTRACT Here, we report a 29-Mb draft genome sequence of strain 72-15.1 of Simplicillium aogashimaense (Cordycipitaceae, Hypocreales). Strain 72-15.1 was a unique fungal isolate obtained from asymptomatic tillers of the tropical grass Brachiaria brizantha.
|
2022-12-10T10:02:50.539Z
|
26,379,674 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/PHT.2013.6461336",
"MAG": "2069889429",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Photoplethysmography (PPG) is a non-invasive optical technique used in detecting blood volume changes in vascular tissue. In recent years, photoplethysmography has generated renewed interest among researchers, particularly due to its potential for widespread clinical applications beyond estimating heart rate and arterial oxygen saturation. Progress in these areas of research is dependent on PPG systems with the ability to record raw photoplethysmographic signals with high signal-to-noise ratio, ideally from more than one channel and one wavelength, for real-time or retrospective analysis. In this work we present the design, development and validation of such a modular PPG system. “Zen PPG” - a portable (16.0 × 10.3 × 5.4 cm) battery operated dual channel, dual wavelength system with the capability to operate with commercial sensors was developed and calibrated using a FLUKE Index 2 SpO2 simulator. A brief study has been conducted on a small group of healthy volunteers to demonstrate the functionality of the system. Red and Infrared PPG signals obtained from volunteers were used to estimate SpO2 and heart rate. These results were compared with simultaneously acquired data from a commercial pulse oximeter (Masimo Radical 7). The SpO2 values showed close correlation between commercial and custom made system (Channel 1: r2 = 0.978; channel 2: r2= 0.708).
|
2022-12-20T13:26:23.477Z
|
142,548,173 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3917/PSUD.028.0055",
"MAG": "1610883533",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Le cas de l’Espagne reflete de facon tres marquee une tendance europeenne vers la proliferation d’institutions nouvelles appelees a faire face aux transformations sociales et demographiques. L’assistance sanitaire en Espagne a traditionnellement ete dispersee en un entrelacs institutionnel dissocie, tributaire des differents niveaux d’autorite (nationale, provinciale et municipale). La creation du SNS en tant que systeme decentralise a implique une reorganisation tres importante de cet entrelacs, en reconsiderant de facon sensible les equilibres institutionnels et en erigeant comme principaux acteurs institutionnels en lice les gouvernements autonomes et le ministere de la Sante. Dans le present expose on analysera l’evolution de la « gouvernance sanitaire » en Espagne, evolution qui se caracterise a la fois par une tendance decentralisatrice forte ainsi que par le developpement de nouvelles formes de gestion publique, souvent marquees par un renforcement du role regulateur de l’Etat.
|
2022-12-23T02:11:27.388Z
|
206,230,065 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1101/gad.250829.114",
"MAG": "2138973294",
"PubMedCentral": "4281566"
},
"license": "CCBYNC",
"status": "GOLD",
"url": "http://genesdev.cshlp.org/content/29/1/7.full.pdf"
}
|
Long-term exposure to PPARγ agonists such as rosiglitazone induces browning of rodent and human adipocytes. Loft et al. discovered that browning triggers reprogramming of PPARγ binding, leading to the formation of PPARγ “superenhancers” that are selective for brown-in-white (brite) adipocytes. They identified KLF11 as a novel browning transcription factor in human adipocytes that is directly induced by PPARγ and appears to cooperate with PPARγ in a feed-forward manner to activate and maintain the brite-selective gene program.
|
2022-12-30T18:42:39.438Z
|
76,027,923 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.12701/yujm.2005.22.2.131",
"MAG": "2341673989",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://www.e-yujm.org/upload/pdf/yujm-22-131.pdf"
}
|
Heart failure is a clinical syndrome comprised of a number of symptoms and signs associated with congestion and/or hypoperfusion. Specific pharmacologic therapies have been developed to slow disease progression from early to more advanced stages. Once symptoms have developed, aggressive multimodality interventions are instituted to alleviate symptoms and improve clinical status and quality of life; especially in those patients that present symptoms. Recently, an evolving adjunctive therapeutic modality, that involves using implanted electrical devices: cardiac resynchronization with or without implantable cardioverter defibrillators (ICD). has been used for management. Cardiac resynchronization therapy (CRT) is a proven treatment for selected patients with heart failure-induced conduction disturbances and ventricular dyssynchrony. When used in combination with stable, optimal medical therapy, CRT is designed to reduce symptoms and improve cardiac function by restoring the mechanical sequence of ventricular activation and contraction. This review summarizes the rationale, procedure, clinical trials, and clinical indications for CRT.
|
2022-08-21T09:53:38.735Z
|
26,247,818 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1136/BMJ.331.7509.160-A",
"MAG": "1982829315",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
EDITOR—I smiled to read that the jury was still out on aspirin to prevent cardiovascular disease in elderly people in This week in the BMJ because, of course, there has never been any sort of jury on this topic.1–2 This debate about aspirin has consumed the medical profession for over 30 years, yet almost no …
|
2022-09-12T01:51:56.669Z
|
34,751,672 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/10428190802549883",
"MAG": "2099274861",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
An increased angiogenesis has been documented in bone marrow and lymph nodes of patients with chronic lymphocytic leukemia (CLL). There is accumulating evidence that circulating endothelial cells (CECs) play an important role in angiogenesis. The aim of our study was to compare the number of CECs in peripheral blood of CLL patients and healthy donors and to correlate these numbers with bone marrow microvessel density (MVD) and known prognostic factors in CLL. Proportions of resting CECs (rCECs), activated CECs (aCECs), apoptotic CECs (apoCECs) and circulating precursor endothelial cells (CPECs) were estimated by flow cytometry in 104 untreated CLL patients and 29 healthy blood donors. The MVD was analysed in the bone marrow biopsy in 21 CLL patients and 11 controls using the ‘hot spot analysis’ of vessels' density (×200 HPS). We found significantly higher numbers of CPECs, rCECs, aCECs and apoCECs in CLL patients than in healthy controls (p < 0.001 for all comparisons). Furthermore, the rCECs number was higher in advanced versus low clinical stage CLL (median 17.5 cells/µL vs. 13.5 cells/µL, p = 0.05). The MVD was significantly higher in the bone marrow of CLL patients when compared with controls (p = 0.016). However, we did not find any correlation between MVD and different CECs populations. In conclusion, the number of CECs is increased in CLL and correlates with stage of the disease, but does not seem to directly reflect the intensity of neovascularisaton in the bone marrow.
|
2022-12-14T12:12:08.593Z
|
23,426,760 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1126/SCIENCE.982064",
"MAG": "1994371688",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Electroconvulsive shock or frontal cortex stimulation administered to rats at 5 but not at 180 minutes after an initial administration of morphine sulfate disrupted the development of one-trial tolerance to the analgesic effects of morphine sulfate. It is suggested that development of tolerance may be mediated by cellular mechanisms and memory processes similar to those thought to underlie conventional learning.
|
2022-12-20T07:41:36.316Z
|
26,645,108 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1074/JBC.M011167200",
"MAG": "2132656979",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
We have employed a yeast two-hybrid system to screen a B lymphoblast-derived cDNA library, searching for regulatory components of the NADPH oxidase. Using as bait the C-terminal half of p67 phox , which contains both Src homology 3 domains, we have cloned JFC1, a novel human 62-kDa protein. JFC1 possesses two C2 domains in tandem. The C2A domain shows homology with the C2B domain of synaptotagmins. JFC1 mRNA was abundantly expressed in bone marrow and leukocytes. The expression of JFC1 in neutrophils was restricted to the plasma membrane/secretory vesicle fraction. We confirmed JFC1-p67 phox association by affinity chromatography. JFC1-containing beads pulled down both p67 phox and p47 phox subunits from neutrophil cytosol, but when the recombinant proteins were used, only p67 phox bound to JFC1, indicating that JFC1 binds to the cytosolic complex via p67 phox without affecting the interaction between p67 phox and p47 phox . In contrast to synaptotagmins, JFC1 was unable to bind to inositol 1,3,4,5-tetrakisphosphate but did bind to phosphatidylinositol 3,4,5-trisphosphate and to a lesser extent to phosphatidylinositol 3,4-diphosphate. From the data presented here, it is proposed that JFC1 is acting as an adaptor protein between phosphatidylinositol 3-kinase products and the oxidase cytosolic complex.
|
2022-12-21T04:13:08.223Z
|
117,906,668 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1063/1.30927",
"MAG": "1644855632",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The energy dependence of the total cross section for the 12C(γ,π−)12N reaction has been studied taking into account the presence of two‐particle‐two‐hole (2P‐2h) correlations in the ground state wave function, in the impulse approximation. The results are in good agreement with the experimental data in the first pion‐nucleon resonance region.
|
2022-02-09T23:00:28.857Z
|
110,067,043 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/ICSENS.2002.1037105",
"MAG": "2110554888",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
It is evident that colour analysis of food is critical in the sale of pre-cooked foods. Through the use of spectroscopy, in the region of the visible and near infra-red spectrum, it is possible to examine different colours and then analyse them. Combining this with Artificial Neural Networks (ANNs), a pattern recognition system is generated to classify between colours that are favourable and those that are not optimum, in an effort to control the cooking process.
|
2022-02-10T05:26:42.387Z
|
149,969,782 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3126/JNGS.V40I0.23598",
"MAG": "2941540428",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Liquefaction hazard zonation mapping of the Saitama City targeted on the Kanto Plain NW Edge Fault is described in this paper. The study involves the geotechnical properties of the alluvial soil of the city including Standard Penetration Test (SPT), shear wave velocity and other geological data analysis. The city being highly urbanized is situated on the soft soil (alluvial deposits) at the proximity of an active seismic fault that has increased the possibility of liquefaction hazard in the area. Kanto Plain NW Edge Fault is an active fault that lies very near to the Saitama City having the estimated possible earthquake magnitude of 7.4. The possible peak horizontal ground acceleration (a max ) from this earthquake is calculated as from 0.15 g to 0.30 g. By considering all possible acceleration values the liquefaction potential maps were prepared and presented in this paper. Additionally, the shear wave velocity is very low and amplification ratio is very high at the marshy deposit but it has comparatively high velocity and low amplification ratio at the marine loam deposit area of the Omiya Plateau. In this paper the liquefaction potential of the area is expressed in terms of liquefaction potential index (P L ). The P L value for the clayey silt deposit in the marshy area with shallow water table is very high. In addition, the P L value in the marine loam deposit of the Omiya Plateau is less which indicates that loam deposit has less liquefaction potential than marshy deposit. The map obtained from this study was validated with the field condition of the study area. Hence, it is expected that this study will assist in characterizing the seismic hazards and its mitigation and will provide valuable information for urban planning in the study area in future.
|
2022-05-31T22:16:49.011Z
|
30,750,411 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1163/092050610X488278",
"MAG": "2013910543",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The water incorporated in a thin film of amphoteric terpolymers composed of various ratios of methacrylic acid (MA), N-[3-(dimethylamino)propyl]methacrylamide (DMAPMA) and n-butyl methacrylate was analyzed using the band shapes of the O–H stretching in the infrared spectra. At an early stage of sorption of water into the polymer film, the O–H stretching band for the water incorporated in the film with comparative contents of MA and DMAPMA residues was similar to that for bulk water. These results clearly indicate that the amphoteric polymers with comparative contents of cationic and anionic groups do not significantly disturb the hydrogen-bonded network structure of water, probably due to the counteraction of the electrostatic hydration effect by the proximity between the anionic and cationic side groups. The number of platelets adhered to the film with comparative contents of MA and DMAPMA residues was relatively the smallest among the examined terpolymer films, which suggested a correlation between the mildness of the charge-balanced polymeric materials to the structure of incorporated water and their blood-compatibilities. In addition, the structure and hydrogen bonding of water in an aqueous solution of co-polymers composed of various ratios of MA and DMAPMA or [3-(methacryloylamino)propyl]trimethylammonium chloride (MAPTAC) were also analyzed using the contours of the O–H stretching in the polarized Raman spectra. The number of hydrogen bonds disrupted due to the presence of one monomer residue (N corr value) for PolyMA was largely positive, and with an increase in the content of the DMAPMA or MAPTAC residues, the N corr value became smaller, and after passing a minimum (which was still slightly positive) at a roughly equivalent molar ratio, the N corr value increased again. This is in a significant contrast with the largely positive N corr values for the homo-polymers (PolyMA, PolyDMAPMA and PolyMAPTAC), and other ordinary polyelectrolytes. The effect of the charge-balanced co-polymer on the hydrogen-bonded network structure of vicinal water observed by Raman spectroscopy was in accordance with that of the charge-balanced terpolymer film observed by infrared spectroscopy.
|
2022-09-06T03:58:51.149Z
|
202,772,918 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.22146/jnteti.v8i3.522",
"MAG": "2972153759",
"PubMedCentral": null
},
"license": "CCBYNCND",
"status": "GOLD",
"url": "https://doi.org/10.22146/jnteti.v8i3.522"
}
|
Nowadays, technology is growing and helping the human work. One of those technologies is object mapping or localization in an indoor environment. The technology is often used to determine position is Global Positionig System (GPS). However, GPS signal is difficult to receive when the device is inside a room or building. Therefore, in this research Indoor Localization is implemented at Telkom Institute of Technology Purwokerto with Wireless Sensor Network (WSN) which uses ZigBee as communication protocol. One of indoor localization stages is distance estimation, which in this case, is carried out using Received Signal Strength Indicator (RSSI) by grouping the value of Path Loss Exponent (PLE) based on room characteristics (clusters). Some methods for position estimation based on number of reference nodes are trilateration and multilateration methods. From the measurement results, the distances estimation with PLE clusters has an error of 0.534 meters and PLE without clusters has an error of 0.903 meters. For accuracy estimation, the best position is obtained on PLE cluster multilateration that has the value of 0,714 meters for Mean Square Error (MSE) and 1.2 meters for the lowest value MSE at trilateration without PLE clusters. The computational time of the four methods (multilateration without PLE clusters, trilateration without PLE cluster, multilateration with PLE clusters, and a trilateration with PLE clusters) are almost identical, between 8.72 to 8.75 second.
|
2022-09-09T04:27:32.042Z
|
83,496,346 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5656/KSAE.2013.11.0.077",
"MAG": "1970231675",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Aphidius colemani and Orius laevigatus aree natural enemies of the control cotton aphid and western flower thrips, which are the major pests of cucumber plants. We evaluated the low toxicity of 47 fungicides against A. colemani and O. laevigatus, and we investigated the simultaneous effect of the natural enemies with fungicide of low toxicity on the pests. The toxicity of DBEDC, hexaconazole, pyraclostrobin, tribasic copper sulfate, triflumizole, chlorothalonil, flusilazole, folpet, carbendazim+diethofencarb, cymoxanil+fenamidone and trifloxystrobin to A. colemani mummies was more than 50% and to O. laevigatus was low toxic. Among the fungicides with low toxicity, azoxystrobin 20% WP was selected because it could be used simultaneously with A. colemani and O. laevigatus and as a fungicide to control powdery mildew and downy mildew. In 2011, the densities of western flower thrips and cotton aphid increased rapidly in early-May in Gongju and Cheonan, Chungnam Province. When azoxystrobin was used at an interval of 10 days in spring, A. colemani and O. laevigatus were released at an interval of 7 days at the early occurrence of the pests. The natural enemies decreased the densities of the pests; the maximum number of A. colemani mummies was 18 per lower leaf, and the maximum number of O. laevigatus was 0.5 per flower. Azoxystrobin did not influence the densities of A. colemani and O. laevigatus. The results show that the selected fungicides can be used with A. colemani and O. laevigatus for the intergrated pest management of cotton aphid and western flower thrips in cucumber polyvinyl house cultivation.
|
2022-04-08T00:56:55.472Z
|
132,849,700 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1017/S0263718900007998",
"MAG": "2586264867",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Abstract The purpose of this article is to investigate the agricultural potential for a selected area in the northeast of Libya. The area is Wadi Derna which lies in the eastern slope of Jabel El Akhdar. The agricultural project is a multi-purpose scheme involving several inter-linked aims. The main ambition is to increase the total percentage of land under crops and to do this by replacing shifting cultivation by settled farming under irrigation. A modified Penman formula was used to calculate the potential evaporation and the deficit of water in the area and to suggest the need for supplementary irrigation.
|
2022-09-15T12:23:29.330Z
|
23,070,527 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/01635581.2017.1362447",
"MAG": "2767521635",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
ABSTRACT Sarsaparilla (Smilax Glabra Rhizome) exerts growth inhibitory effect on multiple cancer cells in vitro and in vivo, and redox-dependent persistent activation of ERK1/2 has been reported to underlie this effect. Here, we report an activation of ATM/ATR-dependent signaling pathway also as a mechanism for the cancer cell growth inhibition induced by the supernatant fraction of the water-soluble extract from sarsaparilla (SW). SW treatment (3.5 μg/μL) promoted the phosphorylations of ATM, ATR, and CHK1 in AGS and HT-29 cells. The ATM kinase inhibitor, KU55933, could reverse SW-induced ERK phosphorylation but not the reduced glutathione/oxidized glutathione (GSH/GSSG) imbalance in AGS cells. However, both the redox inhibitor glutathione (GSH) and ERK inhibitor U0126 antagonized SW-induced phosphorylations of ATM, ATR, and CHK1 in AGS cells. We further found KU55933 significantly antagonized SW-induced S phase arrest, apoptosis, autophagy and the resultant cell growth inhibition. Our results provide another molecular basis for the anticancer action of sarsaparilla.
|
2022-11-24T18:53:59.471Z
|
109,215,161 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5739/ISFP.1999.377",
"MAG": "1972111501",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A novel control valve using MR fluid (MR valve) is proposed for fluid control systems. The MR or Magneto-Rheological fluid is a newly developed functional fluid whose apparent viscosity is controlled by the applied magnetic field intensity wider than that of Electro-Rheological fluid. The MR valve consists of a flow channel between a pair of magnetic poles and the differential pressure is controlled by the applied magnetic field intensity. It features simple, compact and reliable structure without moving parts.An MR valve is fabricated. The magnetic poles have 20mm×3Omm in face size and 3mm in gap length and are connected to an electromagnet. Through experiments on the static characteristics, it is found that the differential pressure is controlled by the applied magnetic field intensity under little influence of the flowrate, which corresponds to a pressure control valve. The differential pressure and output power changes of 0.68MPa and 20W are obtained with the input current and power changes of 710A-turns and 1.9W at the flowrate of 30cm3/s (1.8L/min).
|
2022-11-20T18:10:40.567Z
|
32,265,313 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5694/j.1326-5377.1996.tb101371.x",
"MAG": "2411271547",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The incidence of tuberculosis, in decline in Western countries for years, is increasing again. Inadequate therapy leads to the emergence of multidrug‐resistant tuberculosis, which is difficult to treat and for which there is no effective chemoprophylaxis. Prevention is the most important strategy.
|
2022-12-09T21:00:14.157Z
|
150,070,963 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1027/1015-5759/A000489",
"MAG": "2893197913",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Abstract. The Strengths and Difficulties Questionnaire (SDQ) has been used extensively to screen for possible mental disorders in epidemiological studies around the world. The present study aimed t...
|
2022-12-20T11:39:19.324Z
|
120,843,750 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1117/12.646513",
"MAG": "2060749641",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Stone retropulsion during Ho:YAG (λ = 2.12 μm) laser lithotripsy with various pulse durations (τp: 250 ~ 495 μsec) was investigated. Depending on pulse energy, optical pulse durations were divided into two regimes: short pulse (250~350 μsec) and long pulse (315~495 μsec). Retropulsion distance was measured as a function of pulse energy from 0.4 J to 1.2 J. Calculus phantoms made from plaster of Paris were ablated with a free running Ho:YAG laser using various optical fibers (200, 400, 600 μm) in water. In order to examine the ablation efficiency of two different pulse durations, a single pulse was applied, and the dynamics of the recoil action of a calculus phantom was monitored using a high-speed camera. The correlation among laser-induced topography, ablation volume, and retropulsion was evaluated. Higher pulse energy and larger fibers resulted in larger ablation volume and retropulsion. At a given pulse energy, optical pulses with different durations yielded comparable ablation volumes. The shorter duration pulses induced more retropulsion than longer pulses did at the same pulse energy. Larger retropulsion with the shorter pulse is thought to be induced by higher temperature at the vapor-solid interface, subsequently resulting in faster plume ejection with higher recoil momentum. The results suggest that a longer pulse could minimize retropulsion of the stone during lithotripsy.
|
2022-12-21T18:10:56.844Z
|
3,034,950 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/j.1462-5822.2011.01722.x",
"MAG": "1881100899",
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
NadA (N eisseria meningitidisadhesin A), a meningococcal surface protein, mediates adhesion to and invasion of human cells, an activity in which host membrane proteins have been implicated. While investigating these host factors in human epithelial cells by affinity chromatography, we discovered an unanticipated interaction of NadA with heat shock protein (Hsp) 90, a molecular chaperone. The specific in vitro interaction of recombinant soluble NadA and Hsp90 was confirmed by co‐immunoprecipitations, dot and far‐Western blot. Intriguingly, ADP, but not ATP, was required for this association, and the Hsp90 inhibitor 17‐AAG promoted complex formation. Hsp90 binding to an Escherichia coli strain used as carrier to express surface exposed NadA confirmed these results in live bacteria. We also examined RNA interference, plasmid‐driven overexpression, addition of exogenous rHsp90 and 17‐AAG inhibition in human epithelial cells to further elucidate the involvement of Hsp90 in NadA‐mediated adhesion and invasion. Together, these data suggest an inverse correlation between the amount of host Hsp90 and the NadA adhesive/invasive phenotype. Confocal microscopy also demonstrated that meningococci interact with cellular Hsp90, a completely novel finding. Altogether our results show that variation of host Hsp90 expression or activity interferes with adhesive and invasive events driven by NadA.
|
2022-12-30T01:22:23.040Z
|
144,734,603 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/16841360701835453",
"MAG": "2058866118",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The first wave of reform started in 1999: 1 the pre-existing system, based mainly on a single four-year degree, was replaced by a two-tier system (the so-called 3+2) consisting of a first level of a laurea (L) lasting three years, followed by a two-year laurea specialistica (LS). In the original system, the two tiers were linked together and consequently the credits were counted cumulatively for the laurea specialistica (300 credits, ie 180 for the laurea plus 120 for the laurea specialistica ). The new system was partly reformed again in 2004, 2 separating more clearly the first level from the second one, rearranging the subject matter of the degrees ( classi di laurea ) and redefining the second level degree as laurea magistrale (LM), instead of specialistica .
|
2022-02-09T06:48:35.964Z
|
155,033,095 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/1540-5982.00003",
"MAG": "2160882257",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In this paper we offer a generalization of the circular model of product differentiation by introducing a multiproduct firm facing monoproduct competitors. We prove existence and explicitly characterize equilibrium when transportation costs are quadratic. We exhibit interesting equilibrium features for price policy, market shares, and profits. In equilibrium, the multiproduct firm uses its connected market shares to build asymmetric pricing schemes that allow a fraction of its product line (brands, stores or firms) to be shielded from outside competition and hence extracts maximum consumer surplus. Our results shed some light on the link between product differentiation and mergers and acquisitions activity (M&As).
|
2022-12-11T10:58:32.998Z
|
42,698,345 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3760/cma.j.issn.0366-6999.20130162",
"MAG": "124651608",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Background It has been suggested that glycated hemoglobin (HbA1c) underestimate the actual glycemic control levels in maintenance hemodialysis (MHD) patients, because of anemia and the using of erythropoietin (EPO); it was recommended that glycated albumin (GA) should be an alternative marker. Therefore, the assessment performances of glycemic control were compared between GA and HbA1c in this research by referring to mean plasma glucose (MPG) in diabetes mellitus (DM) patients undergoing MHD or not. Methods MPG was calculated according to the data registered at enrollment and follow‐up 2 months later and corresponding HbA1c, albumin (ALB), GA, etc. were measured in 280 cases. A case‐control study for comparing GA and HbA1c was done among the groups of MHD patients with DM (n=88) and without DM (NDM; n=90), and non‐MHD ones with DM (n=102) using MPG for an actual glycemic control standard. Results In these 3 groups, only for DM patients' (whether undergoing MHD or not), GA and HbA1c correlated with MPG significantly (P <0.01). Through linear regression analysis, it could be found that the regression curves of GA almost coincided in MHD and non‐MHD patients with DM, because the intercepts (2.418 vs. 2.329) and slopes (0.053 vs. 0.057) were very close to each other. On the contrary, regression curves of HbA1c did not coincide in the two groups, because variance of the slopes (0.036 vs. 0.052) were relatively large. Through comparing receiver operating characteristic (ROC) areas under the curve (AUC), it could be understood that the assessment performances of GA and HbA1c in MHD patients were lower than those in non‐MHD ones, and assessment performance of HbA1c in MHD patients was better than GA (P <0.05). In addition, the effects of Hb and EPO dose on HbA1c, or that of ALB on GA were unobvious in our study. Conclusions Actual glycemic control level in MHD patients with DM may be underestimated by HbA1c, and it could be avoided by GA; however, glycemic evaluating performance of HbA1c may be still better than that of GA. Therefore, HbA1c should not be replaced completely although GA can be used as a choice to monitor glycemic level.
|
2022-12-15T01:28:31.793Z
|
21,477,264 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1152/ajprenal.90240.2008",
"MAG": "2159348940",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "https://europepmc.org/articles/pmc2536879"
}
|
We hypothesized that heat shock protein 27 (HSP27), a small heat shock protein with actin-remodeling properties, is involved in the pathogenesis of kidney tubulointerstitial fibrosis. We first examined its expression in the rat unilateral ureteral obstruction (UUO) model of kidney fibrosis and epithelial-to-mesenchymal transition (EMT). Immunoblot analyses showed that UUO resulted in significant upregulation of TGF-beta1, alpha-smooth muscle actin (alpha-SMA), total and phosphorylated HSP27, and phosphorylated p38MAPK. Immunofluorescence studies showed that HSP27 costained with TGF-beta1, alpha-SMA, and E-cadherin in areas of tubulointerstitial injury. We next attempted to translate these studies in an in vitro model of EMT using rat proximal tubular epithelial cells (NRK52E). TGF-beta1 (20 ng/ml) treatment resulted in EMT (upregulation of alpha-SMA and downregulation of E-cadherin) and significant upregulation of total and phosphorylated HSP27 and p38MAPK after 3 days. Real-time PCR analyses showed that HSP27, vimentin, and fibronectin increased whereas E-cadherin mRNA levels decreased. Double-staining immunofluorescence studies showed intracytoplasmic colocalization of HSP27 with both F-actin and E-cadherin in cells undergoing EMT. HSP27 overexpression by transient transfection significantly increased E-cadherin while decreasing E-cadherin repressor Snail levels. In aggregate, these studies show that HSP27 is involved in the pathogenesis of TGF-beta1-induced EMT and chronic tubulointerstitial fibrosis. HSP27 overexpression may delay injury by upregulating E-cadherin through downregulation of Snail.
|
2022-12-18T21:10:34.873Z
|
252,222,941 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1145/3551690.3551695",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The diagnosis of COVID-19 and understanding the condition of the patients who have critical responses is crucial to stop the rapid propagation of such disease. Consequently, diminishing adverse impacts that affected various industrial divisions, especially healthcare. Deep learning methods have proven their great capabilities in studying and analyzing computed tomography (CT) images containing COVID-19. Most related studies utilized the spatial information of CT images to train deep learning models. Nevertheless, training these models with spatial-temporal images could enhance diagnostic accuracy. This paper proposes a computer-assisted diagnostic (CAD) system for COVID-19 diagnosis using three deep learning models trained with spectral-temporal images. First, it uses the multilevel discrete wavelet transform (DWT) to analyze the original CT images and obtain the spectral-temporal images. Then, it uses these images from different DWT levels to train three ResNets deep learning models. Afterward, for each ResNet trained with images of each DWT level, it extracts deep features. Next, for each ResNet, it fuses these deep features and then uses a feature selection approach to reduce their dimension. Finally, support vector machine (SVM) classifiers are used to perform classification. The performance of the proposed CAD proves that training ResNets with spectral-temporal images is better than using CT images. Also, the fusion and feature selection steps have enhanced the diagnostic accuracy, thus the proposed CAD could be employed to help radiologists in COVID-19 inspection.
|
2022-12-24T14:11:08.321Z
|
221,691,300 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.21608/asmj.2019.103083",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "http://asmj.journals.ekb.eg/article_103083_4b1eb0de665d54658c90ed766ca9e5a7.pdf"
}
|
Background: The optimal treatment for ureteral calculi must consider many factors, including stone composition, location and size, patient characteristics, technical skills of the surgeon, and instrument availability. Aim of the Work: To assess the result of ureteroscopic lithotripsy using holmium laser with laproscopic ureterolithotomy in the management of proximal ureteral stones larger than 10mm. Patients and Methods: 80 patients with unilateral upper ureteral stones were randomly divided into two groups: one group underwent ureteroscopic holmium laser lithotripsy (n=40), and another group underwent laparoscopic ureterolithotomy (n=40). Operating time, postoperative hospitalization time, stone clearance rate and perioperative complications were compared. Results: Operation was successfully performed in all 80 cases, and no open surgery was converted in any case. In the ureteroscopy and laparoscopy groups, the mean operating time was 33.83 ± 6.39 min and 107.25 ± 20.13 min, respectively, their hospitalization time was 1.65 ± 0.48 days vs. 3.90 ± 0.63days, and stone clearance rate was 880.0% (32/40) vs. 95% (38/40), and residual stones were removed by extracorporeal shock-wave lithotripsy (ESWL). All patients were followed up for more than three months, and no serious complications such as ureterostenosis occurred. Conclusion: Laparoscopic ureterolithotomy and Ureteroscopy are both effective and reliable for the treatment of proximal ureteral stones. However, considering the shorter operation and hospitalization times we suggest that ureteroscopy, as a minimally invasive method, may be the first choice in the treatment of proximal ureteral stones.
|
2022-01-27T08:57:00.680Z
|