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11,257,980 |
{
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"DOI": "10.1109/PVSC.2005.1488164",
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|
The Schottky barrier formed at the back contact is shown to either act as the commonly accepted back-diode or as a reach-through diode. Rare local spots with low back barrier transparency and/or weak main junctions shunt the photocurrent, thus decreasing the measured open-circuit voltage and device efficiency. This phenomenon was observed experimentally in the case of thin-film CdTe photovoltaics. Combining a proper main junction and an adequate back-contact results in 13% efficient CdTe solar cell without intentional copper doping.
|
2022-02-13T05:26:55.545Z
|
249,667,800 |
{
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"ArXiv": null,
"DOI": "10.36833/lkl.2022.006",
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"license": "CCBYNC",
"status": "GOLD",
"url": "http://casopis.aklcr.cz/doi/10.36833/lkl.2022.006.pdf"
}
|
Facilitation-systemic Therapy is a comprehensive therapeutic system, founded on the methodological basis of Luria's neuropsychological school. It is based on Luria's idea of brain functioning, and on his legacy and the work of many of his colleagues and followers. Facilitation-systemic Therapy is also a set of procedures and methods reflecting the needs of contemporary Czech and (with a slight linguistic modification) Slovakian clinical speech therapy aphasiological practice. It is based on the belief that, in contemporary practice, there is already a widely known number of useful methods and aids that can help in overcoming the difficulties arising from fatal and cognitive disorders, but therapists in clinical Speech Therapy or neuropsychological practice lack a clear justification of when and how to use certain therapeutic methods and aids, how to consistently causally justify the use of a particular method or approach at a given stage of development of a phatic disorder or, conversely, how to reject a certain method at a certain time because of its possible negative effect on the re-education of phatic and cognitive functions. We emphasise the importance of practical training in diagnostics and therapy from Luria ́s positions and, above all, the need to train what are called the “soft skills”, which are another necessary condition for increasing the effectiveness of the therapeutic process. Klíčová slova afázie, agnózie, apraxie, klinické neuropsychologické vyšetření, Facilitačně systémo-
|
2022-07-04T20:45:31.971Z
|
163,975,699 |
{
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"ArXiv": null,
"DOI": "10.1017/S0035869X00042957",
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|
damaged by the hand of man, or by some accident. The explorers belonging to the Cornell expedition have tirst cleaned the inscriptions ; then, having beaten in the squeeze-paper, made a drawing of the same, and afterwards photographed them under the most favourable conditions whilst the paper was still adhering. A final copy was then in each case produced by comparing the first copy, the photograph, and the squeeze together. The result has been something as perfect as it is possible to produce, and many improved readings have been the result of this systematic method of securing trustworthy material. The copies of inscriptions are included in the " plates ", which number twenty-seven; the photographs of sculptures and inscriptions, with and without squeezes attached, amount to forty-five. The latter are half-tone blocks, and in many cases seem to be only moderately successful. The Ivriz sculpture, however, is remarkably good, the boldness of the figure with the bunches of grapes being very noteworthy. The letterpress describes the monuments, and gives a statement of what has hitherto been done on each. Great credit is due to Professor B. B. Charles, who is responsible for the copies, for his part of the work.
|
2022-07-08T19:10:51.612Z
|
95,903,013 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4028/www.scientific.net/AMR.820.11",
"MAG": "2021226165",
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|
Hierarchical eight-arm, star-shaped lead sulfide (PbS) crystals have been successfully synthesized by a simple hydrothermal method. When pyridine was used as solvent, candy-like PbS crystal was obtained. The samples were characterized by X-ray diffraction (XRD), scanning electron microscope (SEM) and Fourier transform-infrared (FT-IR) measurements.
|
2022-09-07T03:40:45.953Z
|
242,144,175 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5433/2237-4876.2019v22n1p114",
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},
"license": "CCBY",
"status": "GOLD",
"url": "http://www.uel.br/revistas/uel/index.php/signum/article/download/36098/25677"
}
|
This paper reports on the implementation of a didactic sequence which addresses the oral genre selection interview, as a support in the construction of a didactic model, focusing particularly on the evaluation process implemented. The interview was constructed as an oral genre, hence as a communicative social practice and the aim was to develop students’ oral skills through activities grounded in Conversation Analysis (CA). The proposal was motivated on account of the research problem that investigates whether it is possible to develop, potentialize and optimize oral skills through the teaching and approach to text/discursive genres in high school, purposely designed for students who are concluding their technical/vocational education. From the research problem, the educational product developed encompasses a common situation to workers, whose preparation lacked a model directed at the applicant (interviewee). The integration of the oral element involved in a text production requires, firstly, a social practice that is built in a collective context, the text is produced by means of interactions. Results bespeak a more conscious learning process involving language adequacy for manifold social practices, especially for formal situations of linguistic-discursive interactions, as is the case of a selective process.
|
2022-11-04T00:09:34.431Z
|
174,811,818 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.1590/1806-9282.65.5.589",
"MAG": "2947453410",
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},
"license": "CCBY",
"status": "GOLD",
"url": "http://www.scielo.br/pdf/ramb/v65n5/1806-9282-ramb-65-05-0589.pdf"
}
|
Our case report shows the complexity of dealing with tracheal tumors, highlighting the importance of the method used for staging. In this report, endoscopic ultrasound (EUS) was crucial to identify the involvement of the esophageal muscular propria in a tracheal tumor and change the surgical planning of the case. Staging this kind of tumor represents a challenge for physicians. There is no evidence in the literature on which methods represent the gold standard for T staging.
|
2022-11-11T07:55:30.020Z
|
144,404,090 |
{
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"ACL": null,
"ArXiv": null,
"DOI": "10.7458/SPP2014753580",
"MAG": "2028947257",
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|
Os programas dos governos sao importantes fontes de informacao para a analise das politicas publicas. Com base nesta assuncao apresentam-se um conjunto de resultados da analise de conteudo tematico destes documentos, com o intuito de compreender o processo de agendamento politico subjacente a introducao dos cursos profissionais nas escolas publicas. Atraves desta analise e possivel ter uma aproximacao ao processo de agendamento e formulacao da medida, identificando as questoes que desencadearam a decisao e os problemas a que pretendeu responder.
|
2022-11-25T01:10:36.108Z
|
8,224,561 |
{
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"ArXiv": null,
"DOI": "10.1158/1078-0432.CCR-07-0944",
"MAG": "2123098020",
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"license": null,
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|
Purpose: The TAX-327 study randomized 1,006 men with metastatic hormone-refractory prostate cancer to receive 3-weekly docetaxel, weekly docetaxel, or mitoxantrone, each with prednisone. Experimental Design: We used the TAX-327 database to address (a) the relationship between quality of life (QoL) and pain; (b) whether minimally symptomatic patients benefit from treatment or have treatment-related decline in QoL; (c) the relationships between prostate-specific antigen (PSA) response, pain response, and QoL response; (d) the times at which these responses are first observed; and (e) whether PSA, pain, and/or QoL response predict for overall survival. Results: At baseline, 374 of 815 men assessed for QoL had major pain; of these, 92% had substantial impairment of QoL compared with 75% without major pain (P < 0.001). Men with minimal symptoms had prolonged survival (median, 25.6 months) compared with symptomatic patients (median, 17.1 months; P = 0.009); they were more likely to have initial deterioration of QoL if treated with weekly docetaxel. PSA response and pain response, but not QoL response, were independently associated with survival in landmark analysis. Median times to PSA and pain response were 44 and 27 days, respectively; some men had initial increase in serum PSA before subsequent decline. Conclusions: Symptoms other than pain contribute to impaired QoL in men with hormone-refractory prostate cancer. Those with minimal symptoms have prolonged survival. Both pain and PSA response are associated with survival but are not adequate to use as surrogate end points in phase 3 studies. Early increases in serum PSA (up to 12 weeks) should be ignored when determining response or progression.
|
2022-12-20T17:23:56.286Z
|
168,881,322 |
{
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"ArXiv": null,
"DOI": "10.2139/SSRN.2922176",
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|
Recent corporate governance initiatives encourage a culture of long-term value creation and growth but cannot work as intended by policymakers. The current discussion about corporate governance ignores the transition from a centralized to a decentralized, unmediated, and interconnected world and from a world of vertical hierarchies to a world of horizontal, open, and autonomous networks. This transition process was initiated and is increasingly accelerated by rapid technological change, including developments in social media, blockchain-based smart contracts, decentralized autonomous organizations, big data, and artificial intelligence. This paper shows how policymakers, regulators, business people, consultants, and other corporate governance experts can re-conceptualize corporate governance in a technology-driven and interconnected world.
|
2022-12-31T19:25:56.493Z
|
131,356,951 |
{
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"ArXiv": null,
"DOI": "10.32473/edis-fr274-2009",
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"license": null,
"status": "BRONZE",
"url": "https://journals.flvc.org/edis/article/download/117777/115800"
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|
FOR-212, a 4-page fact sheet by Chris Demers, outlines 8 steps for forestland owners to set up a smooth transition between themselves and the future owners of their property. Includes references. Published by the UF School of Forest Resources and Conservation, March 2009.
FOR 212/FR274: Ownership Succession: Plan Now for the Future of Your Land (ufl.edu)
|
2022-01-21T00:33:49.392Z
|
221,067,070 |
{
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"ArXiv": null,
"DOI": "10.1080/00357529.2020.1744103",
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"url": null
}
|
A wise man once questioned the need for yet another book on fluorite. Well, between the covers of any book may be an enormous variety of topics, and in the case of fluorite this is particularly tru...
|
2022-01-27T17:36:56.811Z
|
190,024,776 |
{
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"ArXiv": null,
"DOI": "10.4000/revus.1708",
"MAG": "214261795",
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|
Namen tega prispevka je opozoriti na pravno-tehnicne sibkosti argumentacije slovenskega ustavnega sodisca pri t. i. doktrini zlorabe referenduma. Ocitno je ustavno sodisce v preveliki vnemi uresniciti svojo odlocbo prekoracilo ustavne okvire sistema delitve oblasti in tako spodkopalo razmerja med ustavnimi akterji v sistemu zavor in ravnovesij. »Policy« analiza namrec pokaže, da se je tehtnica pri tem nagnila prevec v smer vsakokratne parlamentarne vecine, ki sedaj lahko laže odstrani ovire na poti do uresnicitve svojih politicnih interesov. Slednje lahko na dolgi rok, in nekatera znamenja kažejo na to že sedaj, privede do ustavnega monizma, ki je nasprotje ustavnega pluralizma, v katerem raznoliki politicni in drugi interesi tekmujejo med seboj po pravilih politicnega diskurza, utemeljenega na priznavanju enakih diskusijskih možnosti in na pripravljenosti za sklepanje kompromisov, utemeljenih na nacelih solidarnosti in ustavne strpnosti. Vloga instituta referenduma kot pravice veta, oz. zavore za ustvarjanje ravnovesja, je izjemnega pomena, zato ustavno sodisce odlocanja o njegovem omejevanju ne bi smelo puscati v rokah politicnega diskurza in tekmujocih politicnih sil, ampak bi moralo zanj poskrbeti samo v skladu s pravili pravnega diskurza, ki jih narekuje obstojeci slovenski ustavni red.
|
2022-02-08T09:35:39.427Z
|
51,806,124 |
{
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"ACL": null,
"ArXiv": null,
"DOI": "10.11648/J.IJMFS.20170305.13",
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|
In today’s world, warehousing and distribution centres play a vital role to fulfil customer demand and requirement. Firms cannot ignore the importance of warehouse and distribution centres. In addition, firms are using DCs (distribution centres) and warehouses for valuation addition purposes such as, postponement strategies, break-bulking, consolidation, and packing and packaging etc. This research aim is to develop a model to reduce warehouse cost and increase or improved customer service. The results and discussions with personnel’s of distribution department seem to offer a lesson. It is that, though human distribution “optimizers” out of necessity, must concentrate their efforts on maintaining the most economical primary shipment transportation system, a mechanical “optimizer” like as MODS (model of optimizing distribution centres) is able to find out and determine the most economical system from the standpoint of whole the relevant costs to be considered.
|
2022-04-22T04:52:18.890Z
|
222,436,394 |
{
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"ArXiv": null,
"DOI": "10.1017/S0009840X0099468X",
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}
|
The auos then is the boy's maternal grandfather and may be identified with the Cn. Hosidius Geta whose successes in Mauretania are recorded by Dio Cassius (60. 9) and whose gallantry in Britain (A.D. 43) gained him the ornamenta triumphalia, 5><rre ical Ti/tas imviKiovs, Katrrep ovx vTrarevKws, Xa/3etv (ib. 20). He was consul (suffectus) with L. Vagellius at the close of 45 or 46, G.I.L. x. 1401. In 95 when this poem was written he would have reached a very advanced age; but in all probability he was dead. This also suits the language of the poet better: poscit is more impressive if the claim comes from the dead. The construction praestat nouisse appears to be on the pattern of 'dat habere,' 'tradam portare,'etc.; but praestat may govern nouisse directly.
|
2022-07-09T11:05:05.752Z
|
27,937,766 |
{
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"ArXiv": null,
"DOI": "10.1109/MERE.2008.2",
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}
|
In the development of software-intensive systems, the interaction between customer and supplier is usually text-based. We argue that with agile project management gaining momentum, the inclusion of end-user feedback and a better mutual understanding between customer and supplier on hardware and software design goals becomes increasingly important. We propose the use of video techniques, video-based requirements engineering (VBRE), to support the communication between all stakeholders. The key ingredients of VBRE are user-centric videos and an exploratory environment for creating multi-path scenarios. In this workshop session, the participants will get hands-on experience with VBRE techniques and tools while working on a fictitious airport baggage handling system.
|
2022-09-12T05:38:58.819Z
|
83,666,230 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.1111/j.1749-6632.1989.tb24059.x",
"MAG": "1674246922",
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"status": null,
"url": null
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|
In exploring the link between the endocrine and the immune systems, we studied the modulation of secretion of IL-6 by estrogen in cytokine-induced freshly explanted human endometrial stromal cells. Stromal cells produced IL-6 in response to recombinant interleukin-1 (rIL-1) a or p, tumor necrosis factor, and interferon-gamma. This secretion was strongly inhibited by estradiol-17p at concentrations as low as M. Stromal cell IL-6 proteins in the size range of 23-30 kDa were detected by immunoprecipitation or immunoblotting procedures. The stromal cell IL-6 species were phosphorylated and differentially glycosylated in a manner comparable to the IL-6 secreted by the induced human peripheral blood monocytes and fibroblasts.' However, in contrast to the induction of IL-6 secretion in peripheral blood monocytes and fibroblasts, lipopolysaccharide did not induce the release of IL-6 into the culture medium of stromal cells. The IL-6-induced biological activity in the culture medium of the endometrial stromal cells was assayed by its enhancement of the al-antichymotrypsin secretion by Hep3B2 cells and the neutralization of this activity by anti-rIL-6 antiserum. Whereas the culture medium of the noninduced stromal cells did not exhibit biological activity beyond that seen in the untreated Hep3B2 controls, significant IL-6 biological activity was seen in the culture medium of IL-I-induced stromal cells. The IL-6induced biological activity of the culture medium of the IL-1-induced stromal cells was significantly higher than that seen in the culture medium of stromal cells that were pretreated with estradioLl7D M) and then induced with IL-1. These
|
2022-09-14T09:35:42.242Z
|
45,464,714 |
{
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"DOI": "10.1097/00004694-199703000-00014",
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"url": null
}
|
Two patients had displaced femoral neck fractures at the bone-screw interface after in situ fixation of slipped capital femoral epiphysis. Both fractures required closed reduction and internal fixation. Inadvertent derotation of the femur occurred in both patients and allowed fixation of the fracture through the intramedullary canal of the femoral neck without anterior penetration of the pins into the joint; a nonunion occurred in this patient. The other patient developed chondrolysis and avascular necrosis. Because the femoral neck is vulnerable to stress fractures in young adults, there is some question whether pins placed anteriorly through the femoral neck cortex should be removed.
|
2022-09-21T16:29:27.886Z
|
250,680,916 |
{
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"ArXiv": null,
"DOI": "10.1088/1742-6596/43/1/193",
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"license": null,
"status": "GOLD",
"url": "https://doi.org/10.1088/1742-6596/43/1/193"
}
|
This work is devoted to experimental investigation of a reluctance motor for which the rotor contains bulk superconducting elements to provide different permeabilities along the pole axes and in perpendicular direction. Three materials are under consideration - YBCO monocrystal plates, BSCCO foliate material and the bulk MgB2 plates. A comparative analysis of an output performance of the motor is done at the temperature below 20 K to define the best material with the ratio ‘‘cost-quality’’.
|
2022-09-23T20:18:06.771Z
|
35,155,867 |
{
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"DOI": "10.1177/1087057106286652",
"MAG": "2109272707",
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},
"license": "CCBYNCND",
"status": "HYBRID",
"url": "https://journals.sagepub.com/doi/pdf/10.1177/1087057106286652"
}
|
Naturally occurring mutant forms of p53 are deficient for specific DNA binding. However, their specific DNA binding can be reactivated. The search for small molecules that reactivate latent p53 is considered to be a cornerstone in cancer therapy. The authors describe a new homogeneous fluorescent assay approach for the characterization of binding affinities of human wild-type latent and activated p53 using DNA*spec(26), with and without the addition of the antibody PAb421, respectively, and fluorescence correlation spectroscopy (FCS)/2-dimensional fluorescence-intensity distribution analysis anisotropy as the detection methods. FCS was compared with 2D-FIDA anisotropy, and a very good correlation of the results with both readouts was observed (KDs for nonspecific DNA binding of 24.4 ± 3.5 nM with 2D-FIDA anisotropy and of 29.5 ± 5.5 nM with FCS). The presence of poly(dI-dC) led to a 10-fold increase of binding affinity (KD of 3.3 ± 0.5 nM in the presence of PAb421). 2D-FIDA anisotropy was demonstrated to be the most accurate readout; hence, this detection technology was selected for a 25,000 compound member high-throughput screening (HTS) campaign. The hits obtained were qualified using a novel data evaluation algorithm that identifies false positives and moreover assesses the validity of true hits in the presence of the deteriorating artifact. This process step is of utmost importance for decreasing the attrition in fluorescence-based HTS.
|
2022-11-25T01:16:04.337Z
|
53,544,137 |
{
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"DOI": "10.1002/hyp.10474",
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}
|
Our objectives are (1) to compare tree sap flux density (Js in g cm−2 d−1) and stomatal conductance (Gs in mmol m−2 s−1) across five dominant species, red maple (Acer rubrum), sweetgum (Liquidambar styraciflua), tulip poplar (Liriodendron tulipifera), loblolly pine (Pinus taeda), and oak species (Quercus spp.), (2) to quantity riparian buffer stand transpiration (Es in mm d−1), and (3) to link riparian buffer Es of residual trees to stream discharge. In June 2010, the above species were instrumented with sap flow sensors in a pair (HF1 and HF2) of 12 hectare gauged watersheds. HF1 was clearcut, leaving a 15.2‐m riparian buffer around the stream, and HF2 was the reference. Trees were harvested in the riparian buffer reducing HF1 riparian buffer basal area by 27%. The riparian buffer growing season net radiation increased from 11.9 W m−2 preharvest to an average of 24.3 W m−2 postharvest. HF1 stream growing season discharge increased dramatically (150%) from the preharvest to postharvest period. HF1 2010 preharvest growing season soil moisture was 22.5%. HF1 postharvest growing season soil moisture was 28.5% in 2011, 26.5% in 2012, and 27.2% in 2013. HF2 canopy cover, energy input, and soil moisture showed little change over the same period. From preharvest to postharvest, mean daily growing season Js of trees in HF1 increased in all species. A reduction in HF1 Gs was less evident over the study vapour pressure deficit range in loblolly pine, red maple, and tulip poplar than in oak and sweetgum during the postharvest period. HF1 residual trees in the riparian buffer used 43% more water in growing season postharvest (314 mm) than growing preharvest (220 mm) period. This resulted in an 8% reduction in stream discharge because of an increase in riparian buffer Es. Although clearcutting increased stream discharge, we conclude that the increase in transpiration by the residual trees in the riparian buffer will, at least, partially mitigate the hydrologic effects of forest removal through increased transpiration. Copyright © 2015 John Wiley & Sons, Ltd.
|
2022-12-03T09:18:03.498Z
|
95,291,730 |
{
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"DOI": "10.1021/IE500310C",
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}
|
Metal–organic frameworks (MOFs) have shown tremendous potential for challenging gas separation applications, an example of which is the separation of olefins from paraffins. Some of the most promising MOFs show enhanced selectivity for the olefins due to the presence of coordinatively unsaturated metal sites, but accurate predictive models for such systems are still lacking. In this paper, we present results of a combined experimental and theoretical study on adsorption of propane, propylene, ethane, and ethylene in CuBTC, a MOF with open metal sites. We first propose a simple procedure to correct for impurities present in real materials, which in most cases makes experimental data from different sources consistent with each other and with molecular simulation results. By applying a novel molecular modeling approach based on a combination of quantum mechanical density functional theory and classical grand canonical Monte Carlo simulations, we are able to achieve excellent predictions of olefin adsorption,...
|
2022-12-07T21:52:07.026Z
|
200,053,572 |
{
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"DOI": "10.17549/GBFR.2019.24.1.71",
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|
The purposes of this study were to analyze the structural poverty among rice farmers in East Aceh Regency and to analyze factors causing the structural poverty among rice farmers in East Aceh Regency, Indonesia. Data collection was performed by observation, questionnaire distribution and interview. The research objects were rice farmers in East Aceh Regency. The research locations were 14 (fourteen) sub-districts based on the biggest rice field areas in East Aceh Regency. The data collection technique was purposive sampling. The total sample was 1200 respondents. The model in the present study was descriptive quantitative statistical technique to describe the structural poverty among rice farmers in East Aceh Regency. The analysis and research were performed in 5 (five) stages, i.e. ; (1) distributing questionnaires to the research locations; (2) making data tabulation in the form of table (data coding); (3) performing validity test on data; (4) calculating poverty index score; (5) analyzing data. The research result showed that the structural poverty of rice farmers in East Aceh Regency was due to limited access to education, wage difference and low income of farm workers, limited land ownership (size and ownership status of agricultural land), and limited facilities and infrastructures to support agricultural activities. The indicators of poverty in East Aceh Regency were prosperity level, level of material wealth, education, income, environment, land area, service and politics. Based on the indicators, the score of poverty index among rice farmers in East Aceh Regency was medium, with the score of average poverty index of 57.73 percent. The factors causing structural poverty among rice farmers in East Aceh Regency are the rice farmers’ dependency to higher social classes, structural injustice and structural wealth of farmers, small opportunity to own and control production assets, especially land and capital, development disparity and lack of policy which sided with poor farmers. The implications of this research are that the government continues to implement price stability policies, subsidies and funds programs, and social assistance policies, and any poverty reduction policies will have political implications that have a short-term impact.
|
2022-09-13T17:25:58.312Z
|
240,986,657 |
{
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"DOI": "10.26902/jsc_id60658",
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}
|
Novel compounds (4-amino-2-(phenylamino)thiazol-5-yl)(thiophene-2-yl)methanone and (4-amino-2-(4-chlorophenyl)aminothiazol-5-yl)(thiophene-2-yl)methanone are synthesized and characterized by UV, IR, 1H and 13C NMR, and high-resolution mass spectrometry. The structural optimization and the interpretation of theoretical vibrational spectra is made by the density functional theory calculation using Becke's three-parameter exchange functional in combination with the Lee—Yang—Parr correlation Gaussian 09 program package with the standard 6-311G basis software set. The equilibrium geometry, various bonding features, and harmonic vibrational wave numbers of the titled compound are investigated using the density functional theory calculation. Structural changes in the molecule due to the substitution of the electron withdrawing group are also analyzed. The Mülliken population analysis on atomic charges is performed. The thermodynamic stability in the ground state and reactivity of the compounds in the excited state are explained by the HOMO—LUMO energy gap. The molecular docking study is carried out using Hex 8.0. This study aids to understand the antibacterial activity of the compound.
|
2022-01-27T07:49:51.339Z
|
122,882,219 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/CIC.1992.269511",
"MAG": "2131276137",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The author discusses the computation of the correlation dimension (D/sub 2/) of a time series in the particular case of a signal which is constant for a significant fraction of its length. Two examples are investigated, a periodical signal obtained from a synthesized electrocardiogram (ECG) and the z variable of a Rossler nonlinear system. Such signals are chosen because their correlation dimension values are known. It is shown that the D/sub 2/ obtained by using the algorithm of P. Grassberger and I. Procaccia yields, in both cases, an underestimation of the correct D/sub 2/ value. This problem is discussed and a slight modification of the basic algorithm to reduce this error is proposed.<<ETX>>
|
2022-06-14T08:07:49.438Z
|
167,921,659 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2139/ssrn.2445065",
"MAG": "2287299183",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The controversy over Chinese reverse mergers, which are directly listed on U.S. stock exchanges, has led to concerns about the audit quality of all U.S. listed Chinese companies. Because a sizeable number of foreign firms cross list their shares as American Depositary Receipts (ADRs) issued by U.S. depositary banks (as opposed to directly listed), we study how auditors have managed Chinese ADRs. Our motivation for examining Chinese ADRs is based on the findings that cross-listing via the ADR process is beneficial for U.S. shareholders, generally results in higher valuations, and is less likely to be associated with misreporting. We find that relative to other ADRs, Chinese ADRs are: (1) more likely to be associated with a Big 4 auditor, (2) expected to pay more for their external audits, (3) are likely to have longer audit report lag (proxy for audit investments), and (4) less likely to restate prior period financial statements. When we include Chinese reverse mergers, which are non-ADR companies, we find that the audit quality problems are only confined to Chinese reverse mergers. Our results do not suggest that Chinese ADRs have lower audit quality than other ADRs or Chinese reverse mergers. A key conclusion is that the audit quality concerns of Chinese reverse mergers, or other directly U.S. listed Chinese companies, may not extend to Chinese ADRs.
|
2022-09-10T22:32:37.027Z
|
9,582,128 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/ROBIO.2010.5723369",
"MAG": "2097804564",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Wireless Capsule endoscopy (WCE) has been developed to allow direct view of the entire small bowel in human body in a noninvasive manner for the first time. But the visual inspection of a large number of video frames produced in each examination poses a tedious task to physicians. In this paper, we propose a novel scheme aiming for reduction of the number of frames in a video so as to partially solve this problem. To achieve this goal, the original WCE video is first divided into different segments by detecting video boundary among the video sequence. Key frames from different segments are then extracted to summarize the video with k-means clustering. Preliminary experiments on our present video data verify that it is promising to employ the proposed scheme to abstract a WCE video.
|
2022-09-30T00:06:07.076Z
|
123,286,033 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1103/PHYSREVB.83.174446",
"MAG": "2066172582",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In this study the intrinsic magnetic moments developed in 4 nm bare fcc Au nanoparticles were investigated. The magnetization curves reveal a Langevin magnetic field profile, reflecting the existence of spontaneous magnetic moments. Neutron diffraction measurements detect a ferromagnetic moment. The magnetic diffraction patterns are consistent with a moment of 〈μZ〉 = 0.14 μB points in the crystallographic [111] direction at 5 K. Magnetostatic interparticle interactions weaken the localized magnetic moments but enhance the conduction electron density. These behaviors can be understood by considering the merging of the 5d and 6s electron bands triggered by finite-size effects and the lifting of band mixture by interparticle interactions.
|
2022-10-25T09:15:02.409Z
|
155,241,249 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2139/SSRN.2548551",
"MAG": "2229805570",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
We examine the decline in congressional polarization that occurred during the 1920s, as party differences narrowed relative to the high levels of the turn of the twentieth century – a period that has, until recently, been regarded as the high-water-mark of partisan polarization in American politics. While our results are preliminary, we note two sets of findings. First, procedures may have contributed to depolarization, in that a decline in agenda control and procedural dominance by the majority party in the House seems to have been a significant factor associated with depolarization. That is, as highly polarized roll calls declined and the proportion of less polarized substantive roll calls increased, overall levels of polarization in the House declined. Second, both qualitative and roll call evidence suggests that agricultural and tariff policies were key early areas of interparty cooperation, providing important opportunities for cross-party and cross-regional coalitions (like the Farm Bloc and the Progressive Coalition) to form before the Conservative Coalition emerged in the late-1930s.
|
2022-12-18T07:42:15.790Z
|
30,112,113 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1346/CCMN.1999.0470312",
"MAG": "2122271485",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Adsorptive-type organoclays, where hydrocarbons adsorb directly to the siloxane surfaces, were studied to find new organic cations and to determine the parameters that produce effective sorbents. Organoclays were prepared from hectorite by cation exchange with small, aromatic organic cation salt solutions. Trimefhylphenylammonium (TMPA) chloride was obtained and iodide salts of commercially-unavailable aromatic cations were synthesized and used to prepare organoclays. An aqueous mixture of benzene, toluene, ethylbenzene, and xylenes (BTEX) consistent with the composition of unleaded gasoline was used in sorption isotherms to compare the sorptive properties of the organoclays. Only the TMPA, methylphenylpyridinium (MPPyr), and trimethylammonium indan (Indan) organoclays were effective BTEX sorbents. Organoclays prepared from methylpyridinium (MPyr), trimethylammonium biphenyl (Biphenyl), and trimethylammonium fluorene (Fluorene) were poor sorbents. The MPPyr and TMPA organoclays preferentially sorbed ethylbenzene, whereas the Indan organoclay preferentially sorbed benzene and toluene. Langmuir-type sorption isotherms for the TMPA, MPPyr, and Indan organoclays implied surface adsorption, whereas linear isotherms suggested that partitioning was the sorptive mechanism for the MPyr, Biphenyl, and Fluorene organoclays. Water hydrating the small MPyr cation and the larger bulk of the Biphenyl and Fluorene cations may have blocked BTEX access to the interlayer siloxane surfaces. Although the rather bulky MPPyr and Indan cations produced effective organoclays, compact size and low hydration are organic cation properties that typically yield effective adsorptive-type organoclays.
|
2022-12-20T08:36:17.575Z
|
40,716,995 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1128/MCB.15.10.5707",
"MAG": "1935888165",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Locus control regions (LCRs) are powerful assemblies of cis elements that organize the actions of cell-type-specific trans-acting factors. A 2.3-kb LCR in the human adenosine deaminase (ADA) gene first intron, which controls expression in thymocytes, is composed of a 200-bp enhancer domain and extended flanking sequences that facilitate activation from within chromatin. Prior analyses have demonstrated that the enhancer contains a 28-bp core region and local adjacent augmentative cis elements. We now show that the core contains a single critical c-Myb binding site. In both transiently cotransfected human cells and stable chromatin-integrated yeast cells, c-Myb strongly transactivated reporter constructs that contained polymerized core sequences. c-Myb protein was strongly evident in T lymphoblasts in which the enhancer was active and was localized within discrete nuclear structures. Fetal murine thymus exhibited a striking concordance of endogenous c-myb expression with that of mouse ADA and human ADA LCR-directed transgene expression. Point mutation of the c-Myb site within the intact 2.3-kb LCR severely attenuated enhancer activity in transfections and LCR activity in transgenic thymocytes. Within the context of a complex enhancer and LCR, c-Myb can act as an organizer of thymocyte-specific gene expression via a single binding site.
|
2022-12-23T02:10:43.937Z
|
4,010,490 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1136/bmjopen-2017-019589",
"MAG": "2790674801",
"PubMedCentral": "5855475"
},
"license": "CCBYNC",
"status": "GOLD",
"url": "https://bmjopen.bmj.com/content/bmjopen/8/1/e019589.full.pdf"
}
|
Objective Few studies have examined the causal relationships between lifestyle habits and obesity. With a focus on eating speed in patients with type 2 diabetes, this study aimed to analyse the effects of changes in lifestyle habits on changes in obesity using panel data. Methods Patient-level panel data from 2008 to 2013 were generated using commercially available insurance claims data and health check-up data. The study subjects comprised Japanese men and women (n=59 717) enrolled in health insurance societies who had been diagnosed with type 2 diabetes during the study period. Body mass index (BMI) was measured, and obesity was defined as a BMI of 25 or more. Information on lifestyle habits were obtained from the subjects’ responses to questions asked during health check-ups. The main exposure of interest was eating speed (‘fast’, ‘normal’ and ‘slow’). Other lifestyle habits included eating dinner within 2 hours of sleeping, after-dinner snacking, skipping breakfast, alcohol consumption frequency, sleep adequacy and tobacco consumption. A generalised estimating equation model was used to examine the effects of these habits on obesity. In addition, fixed-effects models were used to assess these effects on BMI and waist circumference. Results The generalised estimating equation model showed that eating slower inhibited the development of obesity. The ORs for slow (0.58) and normal-speed eaters (0.71) indicated that these groups were less likely to be obese than fast eaters (P<0.001). Similarly, the fixed-effects models showed that eating slower reduced BMI and waist circumference. Relative to fast eaters, the coefficients of the BMI model for slow and normal-speed eaters were −0.11 and −0.07, respectively (P<0.001). Discussion Changes in eating speed can affect changes in obesity, BMI and waist circumference. Interventions aimed at reducing eating speed may be effective in preventing obesity and lowering the associated health risks.
|
2022-12-24T11:10:43.045Z
|
130,650,103 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1017/S0016756800187163",
"MAG": "2132143328",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A collection of about twenty specimens of three or four kinds of shales, bearing several Estherian and small Molluscan fossils, was made by Mr. Joseph Mawson, F.G.S., Superintendent of the Bahia and San Francisco Railroad, several years ago, and presented by him to the British Museum. These are marked with the distances, in kilometres, from Bahia on the railway; and are provisionally referred by Mr. Mawson, some to the “Cretaceous” and some to the “Wealden” series.
|
2022-12-24T17:59:25.266Z
|
120,207,961 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1063/1.361052",
"MAG": "1985527491",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Physical vapor deposition technologies have been developed which allow the fabrication of multilayer structures consisting of two yttrium–barium–copper–oxide (YBa2Cu3O7−x or YBCO) layers separated by a thick (∼4 μm), low dielectric constant material. The YBCO is buffered from both the substrate and the other films with ion‐beam assisted deposited (IBAD) films of yttria‐stabilized zirconia (YSZ). The YSZ layer provides both the texture necessary to deposit high‐quality YBCO films and protection from the insulating layer material. Using these deposition processes, a variety of materials, such as Pyrex and Haynes alloy, may be used for the substrate. The critical temperature and current values obtained for the two YBCO layers of the completed structure were on the order of 85 K and 2×105 A/cm2, respectively.
|
2022-02-09T22:28:56.808Z
|
106,927,781 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.9725/KSTLE.1987.3.1.047",
"MAG": "902062698",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The purpose of this paper is to study the lubrication characteristics which is occured in contact surface of two meterials. In this study, experimental apparatus which was modelling of the Cold rolling was used. Electric resistance, the temperature variation and the friction coefficient, between Disk and Roller were measured by respectively electric circuit system, temperature probe, and strain gauge. The experiment carried on the disk velocity range of 10m/min to 1000m/min in loading
|
2022-02-10T08:06:07.687Z
|
156,957,946 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1163/9789004221314_017",
"MAG": "2433649567",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This chapter argues that the mandate and operations of the International Criminal Tribunal for the Former Yugoslavia (ICTY) during war crimes trials have been inherently inimical to a functioning, publicly-accessible archive. Unless its purposes are reoriented to those of an archive, the ICTY's policies, presently tailored to facilitate war crimes trials, could eventually lead to the archive's dismemberment or permanent inaccessibility. The power of sovereign states to inhibit public disclosure of information is embedded in the Rules of Procedure and Evidence (RPE), which bestow on an "entity" providing evidence rights similar to those of a protected witness. The ICTY's current rules and practices leads to suggest that a set of guidelines be established to assure that the archive is truly open, and that the "living archive" be subject to the decisions of an "ombudsperson" with the power to unseal and declassify documents in accordance with those guidelines. Keywords:ICTY; Rules of Procedure and Evidence (RPE); sovereign states; war crimes
|
2022-02-09T00:29:59.511Z
|
73,343,950 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3923/IJPS.2011.440.443",
"MAG": "2156928547",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The Japanese quail is a very popular animal model for various biomedical disciplines such as growth and development, reproduction, physiology, endocrinology, nutrition, drug testing and toxicology. Hematological and clinical chemistry parameters are important diagnostic tools and experimental studies invariably draw on them for evaluating the outcomes of treatments. For blood collection, a wide variety of sites are utilized for sampling blood from animals including the heart. Cardiac puncture is being practiced in rodents, birds and rabbits particularly when larger quantities are needed for diagnostic and serological work. One should, however, be fully aware of possible complications that may result from this method. On this aspect, information on the post-collection responses are lacking in the Japanese quail. This report highlights some important observations made on the Japanese quail following a one-time collection of blood via cardiac puncture. The results were very considerably variable. Of the nineteen (19) experimental birds used in this project, one (1) bird succumbed to the procedure and died instantaneously and the others (n = 18) experienced some temporary loss in body weight, cessation in egg production and regression of th e reproductive organs. The loss in body weight was the maximum by d6 post-collection. At this time (d6), five (5) birds which weighed between 115-118g during the pause and had lost a significant amount of bod y weight (loss of ~ 12% from the initial weight at day 0) were, after blood collection, euthanized with carbon dioxide and their hearts and reproductive organs were examined and fixed in 10% formalin. Most of th e surviving birds (n = 8) regained weight between d3 to d12 post-collection and resumed egg production; however, some birds (n = 2) did not lay eggs even by d12 post collection. Both Hemoglobin (Hb) and Packed Cell Volume (PCV) were significantly elevated during the pause and then returned to their initial values of d0 upon resumption of egg production after the healing process had been compromised. It was implicit that cardiac puncture traumatized the heart and triggered various changes in hormonal and physio-chemical parameters. Post collection pathological alterations included hemopericardium, ventricular hemorrhage and the formation of fibrous tissues in the myocardium and other complications. These points should be kept in mind while planning an experiment or evaluating the outcome of an experiment involving cardiac puncture.
|
2022-02-11T09:09:55.579Z
|
244,319,979 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.12681/eadd/48907",
"MAG": "3130195092",
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
Η παρούσα διατριβή αποβλέπει στην εξέταση τεσσάρων δημογραφικών γεγονότων υπό την προοπτική της οικονομικής επιστήμης. Ειδικότερα, επιχειρεί την διερεύνηση του σχετικού εισοδήματος του Easterlin ως προς την εξέλιξη των εξής δημογραφικών γεγονότων: του γάμου, της γεννητικότητας εκτός γάμου, και του φαινομένου της ηλικιακής μετάθεσης της γεννητικότητας εν γένει. Ο Easterlin θεωρεί ότι τα νεότερα άτομα λαμβάνουν τις αποφάσεις τους επί τη βάσει της σχετικής τους αφθονίας. Αυτό σημαίνει ότι προβαίνουν σε μία σύγκριση, μεταξύ της παρούσης (δυνάμει) κατάστασής τους, και εκείνης που βίωσαν κατά την διάρκεια της παιδικής τους ηλικίας. Ως εκ τούτου, όσο υψηλότερο το επίπεδο διαβίωσής τους ως ανήλικοι, τόσο υψηλότερες οι απαιτήσεις τους στη νεότητά τους. Αυτή είναι, εν συντομία, η υπόθεση του σχετικού εισοδήματος του Easterlin. Προκειμένου να εξετάσουμε αυτήν την υπόθεση, χρησιμοποιούμε μίκρο-δεδομένα από την βάση IPUMS-CPS για την περίοδο μεταξύ 1976 και 2016. Το πεδίο της έρευνά μας είναι οι ΗΠΑ, και ειδικότερα οι λευκοί μη-ισπανοί πολίτες (λόγω προσβασιμότητας). Τα αποτελέσματα επιβεβαιώνουν την διατυπωθείσα υπόθεση. Το σχετικό εισόδημα των ατόμων νεαρής ηλικίας προκύπτει στατιστικά σημαντικό και στα τρία προαναφερθέντα δημογραφικά γεγονότα. Πιο συγκεκριμένα, το σχετικό εισόδημα συσχετίζεται αρνητικά με τη γεννητικότητα εκτός γάμου και του φαινομένου της μετάθεσης της γεννητικότητας εν γένει, αλλά θετικά με τα ποσοστά γάμου σε αυτέ τις ηλικίες. Επιπροσθέτως, βρίσκουμε ότι το σχετικό εισόδημα προβλέπει καλύτερα τα ποσοστά γάμου και την μετάθεση της γεννητικότητας από το απόλυτο εισόδημα, τόσο ως προς το μέγεθος των συντελεστών, όσο και ως προς την στατιστική σημαντικότητα. Εν συνεχεία, εξετάζεται το φαινόμενο της ανάκαμψη της γυναικείας γονιμότητας (fertility rebound). Αυτό το φαινόμενο συνέβη στα τέλη της δεκαετίας του 90 με αρχές του 00 και έλαβε χώρα, κατά κύριο λόγο, στις ανεπτυγμένες χώρες. Η μέχρι τούδε έρευνα το έχει εξετάσει ως προς τον δείκτη της ανθρώπινης ανάπτυξης (HDI) και το κατά κεφαλήν ακαθάριστο εγχώριο προϊόν (GDP per capita). Στο αντίστοιχο κεφάλαιο, προσθέτουμε, επιπλέον, την παραγωγικότητα της εργασίας και τη συμμετοχή των γυναικών στην αγορά εργασίας. Η εξέτασή μας αυτή καλύπτει την περίοδο από το 1970 έως το 2016 για χώρες του ΟΟΣΑ. Σχηματίζουμε δύο ομάδες χωρών (υψηλού και χαμηλού εισοδήματος). Ο στόχος είναι να ανακαλύψουμε εκείνο τον παράγοντα (μεταξύ ακαθάριστου εγχώριου προϊόντος, παραγωγικότητας της εργασίας, συμμετοχής των γυναικών στην εργασία) για τον οποίο τα σημεία καμπής μεταξύ των δύο ομάδων βρίσκονται εγγύτερα, ή και ταυτίζονται (στατιστικά ασήμαντα). Τα εξαχθέντα αποτελέσματα φανερώνουν ότι αυτή η απόσταση ελαχιστοποιείται για την παραγωγικότητα της εργασίας. Στο πρώτο μέρος αυτής της εργασίας, και στηριζόμενοι στην δημογραφία, την οικονομική θεωρία, και ορισμένα πρόσφατα δεδομένα, παραθέτουμε μερικές σκέψεις επί του τελικού αποτελέσματος. Καταλήγουμε ότι η παραγωγικότητα της εργασίας αποτελεί τον σημαντικότερο παράγοντα για την εκκίνηση της ανάκαμψης της γυναικείας γονιμότητας.
|
2022-03-18T00:54:42.800Z
|
95,963,858 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.1080/10256018308544852",
"MAG": "2009816400",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Gastargets konnen in massenspektroskopischen Geratesystemen entweder zur Empfindlichkeitssteigerung, indem das “back-ground” Spektrum auf ein Minimum reduziert wird, oder zur hochempfindlichen Strukturanalyse organischer Verbindungen eingesetzt werden. Die mit Gastargets arbeitenden ultraempfindlichen Massenspektrometer ermoglichen eine hochempfindliche Bestimmung von Isotopenhanfigkeiten und Spurenkonzentrationen bis 10−15 g/g under Einsatz minimaler Probenmengen in geologischem, biologischem und technischem Probenmaterial.
|
2022-09-01T12:35:25.942Z
|
239,457,286 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/jum.15846",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Sonography is conventionally used to diagnose fractures by identifying cortical discontinuity in the bone. However, its usefulness for diagnosing lumbar transverse process fractures (LTPFs) remains unknown. In this series, we describe static and stress sonography findings during manual application of compression stress on the lateral lumbar vertebrae in 17 patients with LTPFs. Features of LTPFs on static sonography included cortical discontinuity (89.3%), hematoma (71.4%), step‐off deformity (67.9%), and focal reverberation echo (78.6%). All LTPFs were confirmed on stress sonography. Thus, stress sonography should be considered for the detection of LTPFs when there is at least one static sonographic fracture sign.
|
2022-09-13T12:29:38.505Z
|
229,426,511 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/02508281.2020.1841376",
"MAG": "3110233679",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
ABSTRACT This study intends to identify and evaluate the preference of tea varieties among the foreign tourists in India. The significant aspects which resulted in the selection of these tea varieties demarcating their importance as a destination attraction are also briefly discussed. A structured survey instrument was used for data collection from 279 inbound foreign tourists applying location intercept method at Delhi International airport (IGI). Analytical Hierarchy Process (AHP) model and chi-square (x 2) statistics were used to evaluate the preference of tea amongst the tourists. A total of 13 tea varieties based on their origin and preparation styles were identified which were found to be most preferred by the tourists, with Darjeeling tea being most favoured and Dooars Terai tea being least favoured. Findings revealed that amongst the seven socio-demographic variables analysed, five have a momentous and significant influence on their inclusive tea preferences. This study also posits on the role of tea as a tactical tool to re-create the destination image of India as a tea tourism destination. It is a novel attempt to examine the tourist's tea preference in India which can be used by stakeholders to entice, rewire and enhance their re-visits.
|
2022-11-05T17:30:39.195Z
|
170,065,557 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5465/AMBPP.2018.14451ABSTRACT",
"MAG": "2831548002",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Ambidextrous search – simultaneous search for solutions closely and distantly from an organization’s current knowledge base – has emerged as a superior approach to address performance problems. Yet...
|
2022-12-25T12:59:00.296Z
|
231,817,187 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3390/ijerph18031356",
"MAG": null,
"PubMedCentral": "7908088"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.mdpi.com/1660-4601/18/3/1356/pdf?version=1612440472"
}
|
Background: While the number of retail interventions with impacts on diet- and/or health-related outcomes is increasing, the economic evaluation literature is limited. This review investigated (i) the cost-effectiveness of health-promoting food retail interventions and (ii) key assumptions adopted in these evaluations. Methods: A systematic review of published academic studies was undertaken (CRD42020153763). Fourteen databases were searched. Eligible studies were identified, analysed, and reported following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. Results: Eight studies that evaluated 30 retail interventions were included in the review. Common outcomes reported were cost per healthy food item purchased/served or cost per disability-adjusted life year (DALY) averted. Four studies undertook cost-utility analyses and half of these studies concluded that retail interventions were cost-effective in improving health outcomes. Most studies did not state any assumptions regarding compensatory behaviour (i.e., purchases/consumption of non-intervention foods or food purchases/consumption from non-intervention settings) and presumed that sales data were indicative of consumption. Conclusion: The cost-effectiveness of retail-based health-promoting interventions is inconclusive. Future health-promoting retail interventions should regularly include an economic evaluation which addresses key assumptions related to compensatory behaviour and the use of sales data as a proxy for consumption.
|
2022-12-23T02:05:51.754Z
|
121,574,672 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4028/www.scientific.net/AMM.204-208.2488",
"MAG": "2010831474",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
To ravel out the difficulty in the expression and measurement of Non-subjected Information in earthquake emergency decision-making under fuzzy environmental conditions, a ranking method was put forward for earthquake emergency events on Intuitionistic Fuzzy Sets. Via the explanation about the concept of Intuitionistic Fuzzy Sets, intuitionistic fuzzy matrix and its interval estimation was established for the set of the earthquake emergency events, and the positive and negative ideal intuitionistic fuzzy earthquake emergency was determined; Through defining the distance calculation about subjected, non-subjected and hesitated degree, and respectively comparing the distance from the emergency to the positive and negative ideal event, the superiority degree model was established for the earthquake emergency events, which further gained the sequence of the emergency event collection. Case showed that model effectively solved the ranking problem about earthquake emergency events, which provided one theory and method for scientific decision-making practice in shock resistance and disaster relief.
|
2023-01-01T18:16:06.924Z
|
59,147,447 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2991/WARTIA-16.2016.109",
"MAG": "2409341566",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Because of lack of aspect-oriented programing technology during the early stage of soft programing, this paper developed a method which combines the aspect-oriented programing technology with formal specification language. Aspect-oriented programing technology separates the different concerns of system.Formal specification language is a language based on logic and mathematics, so it is good to redundancy of ambiguity and reliability of system. This paper is going to extend the Object-Z to have the ability of aspect-oriented programing technology and use it to model the air traffic control system at the end.
|
2022-01-27T15:41:35.342Z
|
164,632,995 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2307/278868",
"MAG": "2587682447",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Immediately after the close of the Second World War, the Carnegie Museum of Pittsburgh supported three seasons of archaeological reconnaissance in the Four Corners region — along Butler Wash, a northern tributary of the San Juan River, and in the rugged and at that time unmapped country lying between White Canyon and Gypsum Canyon, eastern tributaries of the Colorado River in San Juan County, Utah. Fourteen years later, in 1961, Floyd Sharrock and Edward Keane (University of Utah) undertook a study of the resultant records and specimen collections as part of the extensive research program of the Glen Canyon Project. The published report of this study consists essentially of (a) brief statements regarding the location and characteristics of 29 of the sites visited; (b) taxonomic descriptions of 1488 potsherds and vessels; typological descriptions of 460 artifacts of clay, stone, bone and horn, wood, reed, yucca, cedar bark, feathers, fur, skin, cucurbita and corn, and human hair; and commentaries on unworked animal and vegetal specimens and human skeletal remains present in the collections; and (c) the assignment of these materials, except the last mentioned, to 26 sites and to two catch-all proveniences — "42SaOO, San Juan County" and "Butler Wash, General" — as set forth in a four-page table. The verbal descriptions of the artifacts are supplemented in many instances by generally good photographic illustrations. Apparently, had they chosen to do so, Sharrock and Keane could have delineated a number of assemblages showing considerable time depth. But as it stands, the report merely provides descriptive data for comparative uses elsewhere. Its clueless title must be an oversight. The second paper, by David Dibble and Kent Day (University of Utah), presents results of the survey of a small reservoir area on the upper Green River in the Bridger Basin, southwestern Wyoming, which was conducted by the authors in September, 1961, for the National Park Service. Four "historic" sites (abandoned ranch buildings and a grave) and nine archaeological sites (open campsites yielding stone artifacts and chipping waste, and a petroglyph panel) were found in the impoundment area, and two "historic" and five archaeological sites (open camp or workshop sites producing lithic material) were found near the boundaries of the pool. One of the historic sites, a rocky cliff known as Names Hill, bearing the inscribed signatures of hundreds of Oregon Trail immigrants, testifies to the earlier historic interest of this locality. Dibble and Day also recorded two historic sites and one potterybearing and seven nonpottery, open campsites of aboriginal provenience in the vicinity of the reservoir, and they examined several local artifact collections, one of which included a steatite vessel. The few artifacts collected by the investigators and the generally superficial nature of the hearth and detrital sites indicate transitory settlements by aboriginal hunters and gatherers. On typological grounds, the area appears to have been occupied intermittently from Early Prehistoric times (a Folsom-point fragment and points of Scottsbluff type were identified in a local collection), through the Middle Prehistoric period (denoted by occurrences of McKean and Duncan points and large expanding-stem points with barbed or insloping shoulders), to the Late Prehistoric and Early Historic periods. The authors cite as evidence of late aboriginal occupation the presence of small sideand base-notched points, an equestrian figure in the petroglyph panel, pottery resembling "Shoshoni" and "Intermountain Tradition" ware, and the steatite vessel already mentioned. One of the archaeological sites recorded in the Fontenelle Reservoir area was singled out as containing "a significant block of in situ occupational debris." Yet Dibble and Day did not urge further investigation of it "in light of the expense and effort necessary." This conclusion seems unfortunate, considering the meager information available for this area.
|
2022-11-16T17:18:17.060Z
|
208,439,549 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.1182/blood.v122.21.1997.1997",
"MAG": "2980369460",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Farber disease (FD) is a rare and severe inherited metabolic disorder with childhood lethality and no known cure. Farber patients have mutations in ASAH1 , which codes for the protein acid ceramidase (ACDase). ACDase degrades ceramide; it is an essential and ubiquitous hydrolase. Clinical signs of FD include hepatosplenomegaly, granulomas, and histiocytosis. Some FD patients have been reported to have monocytosis and leukocytosis; some also present with neurological impairments. Allogeneic bone marrow transplantation (BMT) has had modest success in treating Farber patients, however it fails in patients with neurological manifestations of the disease. To better understand and improve on BMT for Farber disease, we performed syngeneic BMTs in a mouse model of Farber disease that we have recently generated. In our model a mutation from a patient with dramatically reduced ACDase activity was introduced into the analogous loci in the mouse genome. Our mouse model faithfully recapitulates the clinical signs of FD: mice homozygous for the Asah1 P361R mutation (Hom) show robust and systemic ceramide accumulation, lifespans reduced to 7-13 weeks, growth retardation, hepatosplenomegaly, thymomegaly, and wide-spread histiocytosis. Peripheral blood monocytosis and leukocytosis are evident as are neurological manifestations. Hematopoietic organs are particularly affected, with the spleen, thymus, and lymph nodes of Hom Farber mice all being enlarged compared to wild-type (WT) and heterozygous (Het) littermates. These organs are enlarged because they, along with the bone marrow, are massively infiltrated by foamy histiocytes (manuscript in preparation). In this present study we transplanted bone marrow from 4-5 week-old WT donor mice (pre-treated with 5-fluorouracil to enhance hematopoietic stem cell recovery) into 4-5 week-old Hom mice that were myeloablated with radiation. BMT doubled the lifespan of Hom mice to 21 weeks. Weight loss was also reduced, with Hom mice more closely approaching the weight of WT and Het mice. Hematopoietic organ enlargement was minimalized: spleen and lymph node sizes were significantly reduced and thymii were no longer visible. The prevention of hematopoietic organ enlargement was likely due to a drastic reduction in histiocysosis: much fewer foamy macrophages were found in the organs. Additionally, peripheral blood monocytosis and leukocytosis were prevented. This study demonstrates that BMT is efficacious in the treatment of the peripheral complications of Farber disease, yet it is not a permanent cure especially when the disease has neurological implications. It reveals the specific beneficial effects of BMT on hematopoietic organs in this novel mouse model of FD. Future studies will look at enhancing BMT outcomes in FD by transducing donor hematopoietic stem/progenitor cells with recombinant lentiviral vectors encoding WT ACDase. This combination of BMT and gene therapy in lysosomal storage disorders is clinically relevant as it could be translated for use in FD patients, following future clinical implementation for other disorders of this class, such as Fabry disease, for example.
Disclosures: No relevant conflicts of interest to declare.
|
2022-01-27T04:10:08.129Z
|
25,833,032 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/09553000701326995",
"MAG": "2141295434",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Purpose: For adaptive response (AR) behavior, to model and analyze the dose rate dependence of AR. To examine and to model the influence of time interval between primer and challenge dose on the magnitude of radioprotection. Method and materials: Microdosimetry is used to examine effects of rate of critical volume specific energy depositions on activation of AR and induction of deleterious damage. The dose rate dependent adaptive response data, Shadley and Wiencke and Shadley et al. on AR fading, are analyzed. Results: We obtain good agreement with observed AR behavior. The 4 – 6 hour activation time for AR is from time necessary for the accumulation of enzymatic resources from the increased radioprotective capability for the recognition and repair of deleterious DNA damage and perhaps resources for reduction of RSO. The Shadley and Wiencke data, for the low 1.0 cGy primer dose, is as a result of a minimum rate of specific energy depositions (hits) for adaptive response to become operative and become fully activated. Increased deleterious damage with increased dose rate for a high 50 cGy primer dose is from a reduction in dose rate sparing as the rate approaches acute exposure. Conclusions: The microdosimetric model substantiates the prior observations in Part I that only several radiation-induced charged particle cell nucleus traversals are sufficient to activate adaptive response. Further however we find here that a minimum dose rate threshold is necessary. The model shows promise to provide insight into adaptive response time and dose rate behavior.
|
2022-12-17T01:29:45.229Z
|
25,528,672 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3109/19401736.2015.1137899",
"MAG": "2305920797",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "http://eprints.cmfri.org.in/11934/1/AGKN_Basheer_Mitochondrial%20DNA_2017_Grouper.pdf"
}
|
Abstract Groupers are important commercial fish in many parts of the world. Accurate identification is critical for effective conservation assessment and fisheries management. Genetic barcodes provide a simple and reproducible method for the identification of species even in the absence of taxonomic expertise. The generation of reference barcodes from properly identified specimens is an important first step in this direction. Here, 36 species belonging to the subfamily Epinephelinae (Family: Serranidae) were collected from landings on the west coast of India and Port Blair, Andaman, and partial nucleotide sequence data of the mitochondrial cytochrome C oxidase subunit I (COI) gene was generated. Barcodes for 13 species were developed from Indian waters for the first time. Analysis using the COI gene produced phylogenetic trees in concurrence with other multi-gene studies. Epinephelus fasciatus and E. areolatus were found to be a species complex, as hypothesized in other studies. The DNA barcodes developed in the study can be used for identifying species within Epinehelinae, where taxonomic ambiguity still exists.
|
2022-12-16T06:41:10.208Z
|
67,858,782 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1093/brain/awz004",
"MAG": "2912395639",
"PubMedCentral": "6391606"
},
"license": "CCBYNC",
"status": "HYBRID",
"url": "https://academic.oup.com/brain/article-pdf/142/3/574/27986571/awz004.pdf"
}
|
Microcephaly is a genetically heterogeneous disorder. Through molecular genetic studies, Perez et al. demonstrate that homozygous loss-of-function mutations in C7orf43 (now termed microtubule-associated protein 11, MAP11) cause microcephaly in humans and zebrafish. Functional analyses show that MAP11 associates with α-tubulin in mitotic spindles and influences cell proliferation.
|
2022-12-24T08:45:48.968Z
|
153,841,232 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/j.1467-6451.2009.00394.x",
"MAG": "2016470270",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This article examines the influence of economics on business research using citation data. The share of economics in citations from business is 10.78% until 1995, but only 6.95% for 1996–2003. Four potential explanations for this decline are discussed: interdisciplinary spillover of research is slower than within a discipline; the increasing use of mathematics in economics made economics less useful for business scholars; economics articles are by their nature more long-lived than business articles; business has grown recently more quickly than economics. The data support the second and fourth explanations. Different research spillover occurs but lasts no more than two years.
|
2022-12-28T14:16:04.436Z
|
94,009,439 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.21236/ad0718418",
"MAG": "1537932644",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Abstract : The Aqua-Glo Series II free water detector, for use in measuring the quantity of free (undissolved) water in hydrocarbon fuels, was evaluated. Two dynamic test loops and a batch-blending calibration apparatus were used to check the accuracy and repeatability of the Aqua-Glo Series II. The Aqua-Glo's response to free water in fuel was found to be affected by the presence of fuel additives in the fuel and by the degree to which the water was dispersed in the fuel. Corrosion inhibitors such as Santolene C, AFA-1, and Lubrizol 541 were found to decrease the Aqua-Glo's response to free water while the fuel system icing inhibitor was found to increase the Aqua-Glo's response to free water. A poor dispersion of the free water in fuel, i.e., one that has a few large drops versus a good dispersion, where there are many small drops, resulted in decreased repeatability and a lowered Aqua-Glo response. In general, the Aqua- Glo Series II free water detector was found to be suitable for field use in its present configuration over the range of 2 to 40 milligrams per liter of water in the fuel.
|
2022-01-27T17:04:14.544Z
|
232,889,760 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5005/jsd-7-1-46",
"MAG": "3039416055",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://doi.org/10.5005/jsd-7-1-46"
}
|
Oral squamous papilloma refers to the benign proliferation of stratified squamous epithelium, which exhibits a papillary or verrucous exophytic growth on the surface and is composed of benign epithelium and small amount of connective tissue core that is supportive. It is caused by Human Papillomavirus (HPV) types 6 and 11 (HPV 6 and HPV 11) which contain double stranded DNA. 4 in 1000 persons exhibit oral squamous papilloma and is seen in the age group of 30-50 years with equal sex incidence. It is commonly found on the tongue, hard and soft palate, gingival, buccal, labial or lingual mucosa and sometimes area near to the uvula. Clinically, this lesion presents as an exophytic growth with a verrucous, roughened or cauliflower or wart-like surface and is often a solitary lesion. Histologically, it is a benign proliferative exophytic or verrucous growth lined by stratified squamous epithelium with acanthosis and well ordered stratification. Treatment is conservative surgical excision or use of keratinolytic agents.
|
2022-02-07T21:56:52.529Z
|
125,758,148 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.9734/JSRR/2018/44010",
"MAG": "2957836407",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In this paper, the critical poses of PPS-RRS-PRS Hybrid Parallel Robot Manipulators (HPRMs) are geometrically investigated in Double Algebra (DA) approach. The screw theory and a reciprocal screw of dyad joints borrowed from the projective space to obtain the geometrically symbolic form of the inverse of the Jacobian matrix (J) which is expressed in the Global Wrench System (GWS) term called superbrackets. These superbrackets mean the symbolic form of the joints screw lines which are the Plücker coordinate finite lines or lines at infinity related to the Hybrid Parallel Robot Manipulators (HPRMs). The critical configurations arise when these Plücker coordinate lines vectors become linearly dependent at the vanished points of the superbrackets. The results of the investigation are the following: the four planes defined by the position of the joints intersected at last at one point which means that the fourth plane passes through the point defined by the other three. Both the base frame and mobile platform lie in a parallel plan. The key contribution in this paper is a determination of singularity condition of Robots Manipulators and rigidity framework without algebraic calculus by Grassmann-Cayley Algebra approach. This paper calculated the determinant of the Jacobian Matrices in a coordinatefree manner by developing and reducing the Superbracket expression. A novelty of this research from other research is that the Hybrid Parallel Original Research Article Akonde; JSRR, 21(2): 1-10, 2018; Article no.JSRR.44010 2 Robot with no identical leg was cheeked and investigated by Grassmann-Cayley Algebra. Not only fully parallel robot may be studied using Double Algebra, but no-identical legs hybrid parallel robot should be also analysed using Double Algebra.
|
2022-02-09T16:37:52.692Z
|
41,734,385 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1145/1026763.1026764",
"MAG": "2009817614",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
With apologies to Oldsmobile, today's residential broadband networks are "not your father's networks." Rapid advances on the services, infrastructure technology, competitive, and regulatory fronts are changing the landscape on a continual basis. And a quick look to the future tells us that this period of change is not about to end any time soon. To help attendees better understand the current state of and future direction for residential broadband networks, this presentation will take a close look at the high quality, high bandwidth services and applications that are most in demand by today's end users, and the future services that network operators are promoting. It will also explore the technical developments that are changing the way carriers are delivering services and that are influencing how they are building out their infrastructures. It will conclude with a discussion of the current regulatory environment, which is affecting the players in the residential marketspace, the services being offered, and the technologies being used to deliver them.
|
2022-02-12T03:26:30.549Z
|
8,274,990 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/j.1476-5381.1990.tb12059.x",
"MAG": "2118994545",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://bpspubs.onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1476-5381.1990.tb12059.x"
}
|
1 The influence of hypoventilation or hyperventilation on blood pressure and pulse rate responses to verapamil and nifedipine was studied in chloralose‐anaesthetized rats. 2 Artificial ventilation with room air at a fixed volume of 10 ml kg−1 successfully induced combinations of hypoxaemia, hypercarbia and acidosis at a ventilator rate of 37 strokes min−1 and of hyperoxaemia, hypocarbia and alkalosis at 160 strokes min−1. 3 Hypoventilation caused significant decreases in both the blood pressure and pulse rate, whereas hyperventilation produced significant increases in these parameters. 4 In the controls, intravenous injections of graded doses of either verapamil or nifedipine caused dose‐dependent decreases in mean blood pressure. The effects on pulse rate were not marked. 5 The hypotensive effects of verapamil were significantly more intense in hyperventilated rats, whereas those of nifedipine were significantly less pronounced in hypoventilated animals. The hypoventilated rats exhibited a significant dose‐dependent decrease in pulse rate in response to verapamil administration. 6 It is concluded that cardiovascular responses to verapamil, nifedipine and probably other calcium antagonists are altered in the presence of blood gas abnormalities.
|
2022-07-31T06:22:04.812Z
|
46,475,095 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1042/CS0810491",
"MAG": "2419576722",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
1. This study was designed to examine the production of certain eicosanoids (prostaglandin E2), prostacyclin (as 6-keto-prostaglandin F1 alpha) and thromboxane A2 (as thromboxane B2) by glomeruli isolated from normotensive Wistar-Kyoto and spontaneously hypertensive rats both before and after the administration of one of three angiotensin-converting enzyme inhibitors, captopril, enalapril or fosinopril, for 10 days. 2. Measurements of glomerular eicosanoid production were made under basal conditions and in the presence of excess exogenous arachidonic acid. 3. The production of prostaglandin E2, 6-keto-prostaglandin F1 alpha and thromboxane B2 was greater by glomeruli from untreated spontaneous hypertensive rats (prostaglandin E2 2.24 +/- 0.41, 6-keto-prostaglandin F1 alpha 1.20 +/- 0.13 and thromboxane B2 2.75 +/- 0.43 ng 10 min-1 mg-1 of protein) than by those from Wistar-Kyoto rats (prostaglandin E2 1.41 +/- 0.28, 6-keto-prostaglandin F1 alpha 0.98 +/- 0.11 and thromboxane B2 1.29 +/- 0.24 ng 10 min-1 mg-1 of protein) under basal conditions. However, these differences only achieved statistical significance for thromboxane B2 (P less than 0.01). Similar strain-related differences were noted in the presence of arachidonic acid. 4. The ratio of glomerular (prostaglandin E2 + prostacyclin)/thromboxane A2 production was significantly lower in spontaneously hypertensive rats than in their normotensive counterparts under basal conditions with values of 1.3 +/- 0.18 and 2.2 +/- 0.20, respectively (P less than 0.01). 5. Angiotensin-converting enzyme inhibitors induced significant changes in the glomerular production of some eicosanoids, which differed both between strains and with the nature of the inhibitor.(ABSTRACT TRUNCATED AT 250 WORDS)
|
2022-09-06T17:31:22.161Z
|
145,280,245 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/47.406725",
"MAG": "2128645824",
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
Technical writing tries to be "objective" and "audience-oriented", but it neglects an element of persuasion known in ancient rhetoric as "ethos". This concept translates from the Greek as "character", but that English word does not convey the concept's richness; nor does the Latin "persona", a term sometimes used to describe the narrative voice in technical prose. "Ethos" is the root of "ethics", which tends to objectify values and choices, alienating them from the people making them. In this paper, I suggest that an understanding of "ethos" in all its richness can help writers of technical prose to produce work that, in relation to traditionally "objective" prose, is both more readable and more ethical. >
|
2022-09-12T06:48:24.291Z
|
16,645,938 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/ICASSP.2010.5495693",
"MAG": "2084840410",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Since voxel time courses in functional magnetic resonance imaging (fMRI) are mostly produced from complex-valued data by taking the magnitudes, they obey Rician distributions, which can be approximated as Gaussian distributions only when signal-to-noise ratios (SNRs) are high. In this paper, we derive the asymptotic power of our recently developed activation detection statistic for Rician fMRI. The analysis shows that the asymptotic power is dependent only on the ratios of signal parameters to noise parameter of Rician distributed voxel time series, and allows us to better understand the nature of low SNRs in fMRI data analysis. Based on the power analysis, a more general and descriptive definition of SNR is provided than classical one.
|
2022-12-11T05:02:32.129Z
|
85,858,396 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1586/EOG.12.48",
"MAG": "2123839932",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The success of assisted reproduction technology is highly dependent on a precise selection of gametes and embryos and determining the best endometrial window for embryo implantation. For many years, morphological criteria have constituted the only way to assess spermatozoon, oocytes, embryos and endometrial samples in order to improve outcomes. However, this approach has reached a ceiling of success and has been related to unacceptably high rates of multiple pregnancies. New technologies have been developed in order to improve the results and reduce risks via better selection of those gametes and embryos with the highest pregnancy potential, and of more favorable endometrial environments for embryo implantation. In addition, these technologies should ideally be objective, accurate, fast and affordable. Lately, the global strategies that are being employed in reproductive medicine include genomic, transcriptomic, proteomic, metabolomic profiling of oocytes, cummulus cells, granulosa cells, embryos, endomet...
|
2022-12-16T06:40:30.439Z
|
235,481,829 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1021/acs.analchem.1c02010",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Tumor exosomes with molecular marker-proteins inherited from their parent cells have emerged as a promising liquid biopsy biomarker for cancer diagnosis. However, facile, robust, and sensitive detection of exosomal proteins remains challenging. Therefore, a nanozyme sensor array is constructed by using aptamer-modified C3N4 nanosheets (Apt/C3N4 NSs) together with a solvent-mediated signal amplification strategy for ratiometric fluorescence detection of exosomal proteins. Three aptamers specific to exosomal proteins are selected to construct Apt/C3N4 NSs for high specific recognition of exosomal proteins. The adsorption of aptamers enhances the catalytic activity of C3N4 NSs as a nanozyme for oxidation of o-phenylenediamine (oPD) to 2,3-diaminophenazine (DAP). In the presence of target exosomes, the strong affinity between aptamer and exosome leads to the disintegration of Apt/C3N4 NSs, resulting in a decrease of catalytic activity, thereby reducing the production of DAP. The ratiometric fluorescence signal based on a photoinduced electron transfer (PET) effect between DAP and C3N4 NSs is dependent on the concentration of DAP generated, thus achieving highly facile and robust detection of exosomal proteins. Remarkably, the addition of organic solvent-1,4-dioxane can sensitize the luminescence of DAP without affecting the intrinsic fluorescence of C3N4 NSs, achieving the amplification of the aptamer-exosome recognition events. The detection limit for exosome is 2.5 × 103 particles/mL. In addition, the accurate identification of cancer can be achieved by machine learning algorithms to analyze the difference of exosomal proteins from different patients' blood. We hope that this facile, robust, sensitive, and versatile nanozyme sensor array would become a promising tool in the field of cancer diagnosis.
|
2022-12-21T17:14:26.457Z
|
143,659,521 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3917/TH.664.0377",
"MAG": "2011925416",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
L’objectif de cette etude visait a observer les differentes tenues en main des couteaux dans les ateliers de decoupe de viande et a etudier en quoi ces tenues pouvaient intrinsequement constituer un risque de TMS du membre superieur. L’observation directe et par video a permis de mettre en evidence une grande variabilite des tenues en main selon les secteurs d’activites et les tâches observees. Une variabilite a egalement ete observee au sein de tâches identiques realisees par des operateurs differents. Des positions particulieres de la main et des doigts sur le couteau sources de sursollicitations biomecaniques ont egalement ete identifiees. Enfin, cette etude a egalement mis en evidence des frequences de changement tenue en main tres elevees. Quelques recommandations sont proposees au cours de la discussion afin de reduire le risque de TMS en relation avec la facon de tenir en main le couteau.
|
2022-02-09T07:22:40.733Z
|
17,969,999 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5808/GI.2016.14.2.46",
"MAG": "2473437725",
"PubMedCentral": "4951400"
},
"license": null,
"status": null,
"url": null
}
|
Diverse somatic mutations have been reported to serve as cancer drivers. Recently, it has also been reported that epigenetic regulation is closely related to cancer development. However, the effect of epigenetic changes on cancer is still elusive. In this study, we analyzed DNA methylation data on colon cancer taken from The Caner Genome Atlas. We found that several promoters were significantly hypermethylated in colon cancer patients. Through clustering analysis of differentially methylated DNA regions, we were able to define subgroups of patients and observed clinical features associated with each subgroup. In addition, we analyzed the functional ontology of aberrantly methylated genes and identified the G-protein-coupled receptor signaling pathway as one of the major pathways affected epigenetically. In conclusion, our analysis shows the possibility of characterizing the clinical features of colon cancer subgroups based on DNA methylation patterns and provides lists of important genes and pathways possibly involved in colon cancer development.
|
2022-02-13T00:01:41.641Z
|
37,513,450 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1364/OL.16.000165",
"MAG": "1916844592",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
We demonstrate a switchable, parallel optical image adder/subtractor, using a Michelson interferometer configured with a phase-conjugating mirror. With the path difference of the interferometer legs within the coherence length of the laser, coherent image subtraction is obtained. By electronically switching the beam in one of the legs in the interferometer into an extra length, beyond the coherence length of the laser, incoherent image addition is performed. Two simple experiments showing the switching characteristics and the arithmetic operations are described. This kind of device should find applications in image processing and optical computing.
|
2022-09-02T05:26:47.031Z
|
116,680,904 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/CAV.V21:3/4",
"MAG": "2151627472",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Affect has been shown to influence respiration in people. This paper takes this insight and proposes a real-time model to express affect through respiration in virtual humans. Fourteen affective states are explored: excitement, relaxation, focus, pain, relief, boredom, anger, fear, panic, disgust, surprise, startle, sadness, and joy. Specific respiratory patterns are described from the literature for each of these affective states. Then, a real-time model of respiration is proposed that uses morphing to animate breathing and provides parameters to control respiration rate, respiration depth and the respiration cycle curve. These parameters are used to implement the respiratory patterns. Finally, a within-subjects study is described where subjects are asked to classify videos of the virtual human expressing each affective state with or without the specific respiratory patterns. The study was presented to 41 subjects and the results show that the model improved perception of excitement, pain, relief, boredom, anger, fear, panic, disgust, and startle. Copyright © 2010 John Wiley & Sons, Ltd.
A real-time model of respiration is used to simulate respiratory patterns for 14 different affective states. These patterns are drawn from the literature on respiration and affect. Our results indicate that people perceive most of these affective states better if appropriate respiratory patterns are used.
|
2022-11-09T14:41:30.816Z
|
226,127,624 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.21608/jsec.2020.94608",
"MAG": "3035345146",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://jsec.journals.ekb.eg/article_94608_38ed2ec722ed21c71a168da85ea3da29.pdf"
}
|
تهدف هذه الدراسة إلى قياس تأثير أبعاد استراتيجية التسويق العکسي ( رفع الأسعار، و نشر الوعي من خلال الاعلانات المضادة ، و برمجة التوزيع) على نية المستهلک لتقليل الاستهلاک المنزلي للطاقة الکهربائية عند توسيط ثقافة المستهلک. وقد تم الاعتماد علي قائمة استقصاء قوامها 337 مفردة في جمع البيانات الأولية اللازمة لاختبار فروض الدراسة علي عملاء شرکة جنوب القاهرة لتوزيع الکهرباء بمصر محل الدراسة ( الاستهلاک المنزلي فقط ) خلال فترة الدراسة.
وتوصلت الدراسة إلى وجود تأثير معنوي إيجابي لأبعاد استراتيجية التسويق العکسي (رفع الأسعار، و نشر الوعي من خلال الاعلانات المضادة) على نية المستهلک لتقليل الاستهلاک المنزلي للطاقة الکهربائية ، وعدم وجود تأثير معنوي إيجابي لبرمجة التوزيع على نية المستهلک لتقليل الاستهلاک المنزلي للطاقة الکهربائية، و توصلت إلى وجود تأثير معنوي إيجابي لأبعاد استراتيجية التسويق العکسي (رفع الأسعار ، ونشر الوعي من خلال الاعلانات المضادة ، وبرمجة التوزيع) على المتغيرات الاجتماعية ، کما توصلت إلى وجود تأثير معنوي إيجابي لأبعاد استراتيجية التسويق العکسي (رفع الأسعار ، ونشر الوعي من خلال الاعلانات المضادة ، وبرمجة التوزيع) على السمات الشخصية ، وتوصلت أيضا إلى وجود تأثير معنوي إيجابي لأبعاد استراتيجية التسويق العکسي (رفع الأسعار ، ونشر الوعي من خلال الاعلانات المضادة ، و برمجة التوزيع) على العادات والتقاليد ، و وجود تأثير معنوي إيجابي لأبعاد استراتيجية التسويق العکسي (رفع الأسعار ، و نشر الوعي من خلال الاعلانات المضادة ، وبرمجة التوزيع) على القيم الدينية ، وکذلک توصلت إلى وجود تأثير معنوي إيجابي لأبعاد ثقافة المستهلک (المتغيرات الاجتماعية ، والسمات الشخصية، والعادات والتقاليد) على نية المستهلک لتقليل الاستهلاک المنزلي للطاقة الکهربائية ، وعدم وجود تأثير معنوي للقيم الدينية على نية المستهلک لتقليل الاستهلاک المنزلي للطاقة الکهربائية ، وأظهرت النتائج انه يختلف التأثير المعنوي لأبعاد استراتيجية التسويق العکسي ( رفع الأسعار ، و نشر الوعي من خلال الاعلانات المضادة ، وبرمجة التوزيع) على نية المستهلک لتقليل الاستهلاک المنزلي للطاقة الکهربائية عند توسيط ثقافة المستهلک ، کما أشارت النتائج إلى وجود تأثير معنوي للخصائص الديموجرافية (مستوى التعليم ، ومستوي الدخل الشهري) على العلاقة بين أبعاد استراتيجية التسويق العکسي وأبعاد ثقافة المستهلک و نية المستهلک لتقليل الاستهلاک المنزلي للطاقة الکهربائية، وعدم وجود تأثير معنوي للخصائص الديموجرافية (النوع ، والسن) على العلاقة بين أبعاد استراتيجية التسويق العکسي وأبعاد ثقافة المستهلک و نية المستهلک لتقليل الاستهلاک المنزلي للطاقة الکهربائية .
|
2022-01-23T02:28:54.239Z
|
140,556,377 |
{
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"ArXiv": null,
"DOI": "10.1080/00357529.2015.1034499",
"MAG": "1902775023",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Many years ago (1971) a paper appeared in the American Mineralogist titled “A Pseudomorphic Quartz-Tourmaline Relationship from Northern Nigeria.” I remember it well because I was troubled by the explanation provided by the author (McCurry 1971). What she described are color-zoned tourmaline crystals from a pegmatite that have cores composed of aggregates of quartz grains. The tourmaline crystals—presumably elbaite, but she did not specify—are brown, but there are remnants that are green; from these McCurry surmised that the tourmaline cores were also green. The green cores, except for these remnants, McCurry writes (p. 1476), appear to have been replaced by quartz, “the replacement being limited by a zone of differing composition.” This assessment was based upon the optical properties of the two zones; the green is suggested to have a 7 weight percent iron content in the form of FeO, the brown a 9 weight percent iron in the form of Fe 2 O 3 . McCurry further suggested (p. 1476) that “it seems possible that Fe is more readily removed by hydrothermal solutions than Fe, a process perhaps facilitated by the lower percentage of total iron in the green zones.” In essence, what McCurry is describing are color-zoned tourmaline crystals where the green cores have been eaten away, leaving shells of brown tourmaline that probably would have looked very much like the green elbaite shell from Brazil in figure 1. She proposed that due to subtle differences in chemistry, the green zone was attacked and almost totally removed, whereas the brown zone was effectively left unaltered. She supported this assumption by noting that the interiors of the brown shells consist of longitudinal striated surfaces, very similar to what is typically seen on the outsides of prisms of tourmaline crystals and can be observed on the interior of the green shell from Brazil (fig. 1). Subsequent to this, she writes, the brown shells became filled with “a mosaic of irregular, strained quartz grains, their optic axes almost in parallel alignment” (McCurry 1971, p. 1474). What McCurry described, therefore, is a classic example of a pseudomorph by infiltration. A cavity was created by the removal of a crystal, in this instance only the interior of the crystal, and then that cavity was filled by another mineral. This was a scenario that at the time I found very difficult to accept. It did not appear to me to be a reasonable explanation, although I was unable to offer a different one. Tourmaline Crystals JOHN S. WHITE PO Box 332 Stewartstown, Pennsylvania 17363 john@jwkustos.com
|
2022-02-09T08:59:36.747Z
|
56,635,687 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.7600/JSPFSM1949.33.119",
"MAG": "2517253104",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Competitive gymnasts are confronted with the problem of weight loss before a competition. They intend to decrease body fat, but not muscle. One of the most reasonable method for the purpose is a dieting. Neverthless, a dieting often leads to decrease not only body fat but also lean body weight (LBW) of which 47% is composed of muscle. That is, a dieting has the possibility of decreasing the competitive performance. The well-regulated diet is, therefore, required very much for weight loss of the gymnasts. The body composition (under-water weighing), physical working capacity (submaximal endurance capacity, muscle strength and vertical jump) and blood constituents of seven female gymnasts were measured before and after the 33 day-diet. They, ranging from 18 to 22 years of age, were high ranked athletes in Japan. The diet program was arranged by the dietitian taking gymnasts' favours into consideration. The averaged daily diet evaluated by means of a dietary recall had 1194 kcal with 54.7 g of protein, 28.5 g of fat and 179.9 g of carbohydrate. On the other hand, the usual intakes just before the dieting were 1722 kcal in energy, 43.0 g in protein, 57.1 g in fat and 269.2 g in carbohydrate. All the intakes of vitamins and minerals of the diet were higher than the Japanese recommended dietary allowance (RDA). They practiced about four hours a day, six days a week, during the diet period. The daily energy expenditures before and at the last stage of the dieting were 2332 kcal and 2551 kcal on the average respectively, which were estimated through motion and time study. After the dieting body weight decreased significantly from 52.11 kg to 48.35 kg, of which difference was composed of 2.99 kg of body fat and 0.77 kg of LBW. The decrease of body fat was statistically significant, but LBW was not so. Concerning all the physical working capacities in oxygen uptake and heart rate, muscle strength except trunk extension strength, and vertical jump, there were no significant changes after the dieting. But respiratory exchange ratio (R) decreased significantly at the same work loads. This decrease suggested increased usage of stored body fat as energy during daily practice, and might support the significant decrease of body fat. Most of blood constituents were still in normal ranges in spite of significant changes. Marked change was found in serum FFA which increased three times after the dieting. This change also meant the increased usage of body fat after the dieting. These data indicated that the diet program arranged in this study proved successful and the wellregulated diet was very effective in conditioning the body composition and the physical working capacity of female gymnasts. (J. Physical Fitness Japan 1984, 33: 119•`129) key words : diet, body composition, physical working capacities.
|
2022-07-17T04:28:30.321Z
|
44,775,604 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1136/sti.43.3.166",
"MAG": "2021942761",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://sti.bmj.com/content/sextrans/43/3/166.full.pdf"
}
|
Gonorrhoea is the most common venereal disease, with an attack rate conservatively estimated at about a million new cases per year in the United States (USPHS, 1965a). Aqueous procaine penicillin G, in a dose of 2-4 million units, is presently considered the drug of choice for the treatment of gonorrhoea in males (USPHS, 1965b). However, studies in vitro, including both cases of therapy failures and those from routine admissions, show that in 1963 and 1964 the concentration of penicillin required to inhibit all strains was up to 15 times greater than that which was adequate in 1955 (Thayer, Samuels, Martin, and Lucas, 1965). The frequency of penicillin hypersensitivity, which is estimated at 10 per cent. and which may be increasing (USPHS, 1961), makes the search for an alternate antimicrobial agent desirable. An ideal drug would be one which would achieve a cure with a single oral dose, be of low cost, and have no adverse reactions. Parenteral administration is painful, requires large numbers of syringes and needles, and is apt to cause complications at the injection site (McKechnie and Yow, 1960). There is also a greater possibilityof sensitizing the patient to the therapeutic agent and of eliciting hypersensitivity reactions in patients previously sensitized by parenteral medication. One-dose therapy, given in a clinic, is attractive because patients frequently do not complete a longer course of oral therapy which depends on selfadministration. Oxytetracycline HC1 (Terramycin, Pfizer) in a dose of 1-5 g. orally, based on a short trial with varying dosages, appeared worthy of clinical evaluation. Oxytetracycine is not new to the list of agents useful in the treatment of gonorrhoea. Hendricks, Greaves, Olansky, and five others
|
2022-08-20T17:59:48.112Z
|
204,044,109 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.15207/JKCS.2019.10.9.063",
"MAG": "2975770102",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The purpose of this study was to investigate the effect of hyper-extended knee and asymmetric standing posture on knee joint position and lower extremity muscle activity. Thirty-three voluntary participants participated and included sixty legs in the study. The sixty legs were divided into two groups: hyper-extended knee and normal group. The muscle activity and knee extension angle were measured. In the asymmetric standing posture, the knee joint extension angle and the muscle activity of the gastrocnemius were statistically significant between the normal group and the hyper-extended knee group. Based on the results, we confirmed that the asymmetric standing posture increases the hyper-extended knee. Therefore, it will contribute to the establishment of therapeutic guide for the subjects with hyper-extended knee to maintain the symmetrical standing posture, and future studies need to be conducted including the effects of the hip joint and ankle joints.
|
2022-09-07T03:08:09.073Z
|
128,454,865 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.18452/15741",
"MAG": "1832607197",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
20
|
2022-09-12T00:10:31.034Z
|
29,855,741 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/j.1532-5415.1986.tb04907.x",
"MAG": "2050741975",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
everal cases of “mercy killing,” in which the victim had progressive dementia of the Alzheimer type, were recently reported. These S cases involved the shooting of a 72-year-old nursing resident by his brother in Texas in 1982, and a 62-year-old screaming hospital patient by her husband in Florida in 1983.’ Last winter a 75-year-old retired engineer, Roswell Gilbert, shot his 73-year-old wife who was suffering from dementia and osteoporosis.’ Most recently a physician was indicted for administering a lethal dose of insulin to his demented friend.2 Although the first two killers were not sentenced to jail, Gilbert received life sentence. In addition, the executive clemency board refused to grant clemency in his case. Gilbert was quoted as saying after the verdict that he still does not believe that he committed a murder and that the laws have to be changed. ’ Do we need to change our laws to allow “mercy killing?” I would like to argue that in most cases the tragedy of “mercy killing” is due to inappropriate use of medical technology and lack of consensus among philosophers and courts concerning ethical and legal acceptability of limited medical care for patients in a vegetative state, and for patients with advanced dementia. Some theologians and philosophers argue that there is no moral difference between killing somebody and letting somebody die when the death can be
|
2022-09-13T20:05:48.323Z
|
250,559,228 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1097/MD.0000000000029457",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The aim of this study was to investigate the utility of amide proton transfer (APT) imaging for the determination of human papillomavirus (HPV) status in patients with oropharyngeal squamous cell carcinoma (SCC). Thirty-one patients with oropharyngeal SCC were retrospectively evaluated. All patients underwent amide proton transfer imaging using a 3T magnetic resonance (MR) unit. Patients were divided into HPV-positive and -negative groups depending on the pathological findings in their primary tumor. In APT imaging, the primary tumor was delineated with a polygonal region of interest (ROI). Signal information in the ROI was used to calculate the mean, standard deviation (SD) and coefficient of variant (CV) of the APT signals (APT mean, APT SD, and APT CV, respectively). The value of APT CV in the HPV-positive group (0.43 ± 0.04) was significantly lower than that in the HPV-negative group (0.48 ± 0.04) (P = .01). There was no significant difference in APT mean (P = .82) or APT SD (P = .13) between the HPV-positive and -negative groups. Receiver operating characteristic (ROC) curve analysis of APT CV had a sensitivity of 0.75, specificity of 0.8, positive predictive value of 0.75, negative predictive value of 0.8, accuracy of 0.77 and area under the curve (AUC) of 0.8. The APT signal in the HPV-negative group was considered heterogeneous compared to the HPV-positive group. This information might be useful for the determination of HPV status in patients with oropharyngeal SCC.
|
2022-09-16T02:29:24.003Z
|
4,389,338 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3389/fpsyg.2018.00414",
"MAG": "2795056655",
"PubMedCentral": "5883147"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.frontiersin.org/articles/10.3389/fpsyg.2018.00414/pdf"
}
|
Although the left hemisphere is critical for language, clinical, behavioral, and neuroimaging research suggest that the right hemisphere also contributes to language comprehension. In particular, research has suggested that figurative language may be one type of language that preferentially engages right hemisphere regions. However, there is disagreement about whether these regions within the right hemisphere are sensitive to figurative language per se or to other factors that co-vary with figurativeness. In this article, we will review the neuroimaging literature on figurative language processing, focusing on metaphors, within the context of several theoretical perspectives that have been proposed about hemispheric function in language. Then we will examine three factors that may influence right hemisphere engagement: novelty, task difficulty, and context. We propose that factors that increase integration demands drive right hemisphere involvement in language processing, and that such recruitment is not limited to figurative language.
|
2022-11-02T20:09:15.767Z
|
35,228,342 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/j.1463-1318.2009.01898.x",
"MAG": "1994583257",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Aim The aim of the study was to investigate the frequency and detail of family history recorded for patients diagnosed with potentially high‐risk colorectal cancer, and to determine the proportion of these patients referred to a high‐risk assessment clinic.
|
2022-12-16T05:48:00.450Z
|
196,489,740 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.20960/nh.1675",
"MAG": "2799650232",
"PubMedCentral": null
},
"license": "CCBYNCSA",
"status": "GOLD",
"url": "https://doi.org/10.20960/nh.1675"
}
|
Introduccion: aparte de los conocidos efectos de la vitamina D sobre la homeostasis fosfo-calcica, en los ultimos anos estan cobrando gran relevancia sus efectos extraoseos. Objetivos: conocer la concentracion de 25(OH) vitamina D en pacientes recien diagnosticados de cancer y comprobar si existen diferencias entre los distintos tipos de cancer. Material y metodos: estudio transversal de una cohorte de pacientes recien diagnosticados de cancer que fueron remitidos a Consultas Externas de Endocrinologia para una valoracion nutricional preoperatoria. Se revisaron 139 historias clinicas y se obtuvieron los datos sociodemograficos, biometricos y la concentracion de 25(OH) vitamina D de los pacientes. Resultados: de los 139 pacientes, 71 padecian cancer urologico; 27, cancer colorrectal (CCR); 35, cancer de cabeza y cuello (C y C); y seis, cancer de otro tipo. La concentracion media de 25(OH) vitamina D fue de 50,41 nmol/l (IC 95% = 46,68-54,14). El 57,97% presento deficit de vitamina D (< 50 nmol/l) y un 21,74%, insuficiencia (50-75 nmol/l). Hallamos una mayor prevalencia de deficit estadisticamente significativa (p < 0,01) en el C y C frente al cancer urologico: 68,57% y 49,29% respectivamente. La estacion del ano modifica de manera significativa la concentracion de 25(OH) vitamina D (p < 0,01). Conclusiones: hay una alta prevalencia de deficit de vitamina D en los pacientes recien diagnosticados de cancer (sobre todo en CCR y C y C); por ello, se debe priorizar la correccion de los niveles de 25(OH) vitamina D en estos pacientes. La utilizacion de valores de referencia ajustados segun la estacion del ano podria mejorar la interpretacion de resultados.
|
2022-09-05T08:19:18.439Z
|
79,533,840 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5455/jtomc.2017.06.090",
"MAG": "2768245159",
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
Alopecia is defined as hair loss of more than 100 hairs per day. The pharmacopoeial alopecia is a reversible side effect that usually manifests itself with noncicatricial diffuse hair loss which occurs in the first 3 months using drugs and disappears after the cessation of treatment. Today, the agents most responsible for this side effect are antineoplastics, antithyroid drugs, and antiepileptics. Psychotropic agents are also thought to cause alopecia.
|
2022-02-11T03:56:31.222Z
|
120,159,539 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1088/0305-4608/8/11/004",
"MAG": "1994941345",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
It is shown that recent high-field magnetisation data of YCo2 and LuCo2 by Schinkel (1978), which he calls anomalous because neither band theory nor spin fluctuation theory accounts for them, can be explained by the Fermi liquid model of magnetism through the logarithmic field dependence of the magnetisation.
|
2022-08-24T20:59:50.854Z
|
26,171,826 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/HED.1076",
"MAG": "2162374074",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This study was undertaken to determine the frequency and timing of re‐operation for bleeding following thyroidectomy (THY) and parathyroidectomy (PARA) as well as the implications of this concerning the safety of ambulatory surgery.
|
2022-09-15T16:26:12.657Z
|
226,319,311 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2987/19-6883.1",
"MAG": "3093805348",
"PubMedCentral": null
},
"license": null,
"status": "GOLD",
"url": "https://meridian.allenpress.com/jamca/article-pdf/36/2s/61/2617591/19-6883_1.pdf"
}
|
Hurricane Harvey has been recorded as the wettest cyclone in United States history, resulting in devastating and catastrophic flooding for the Texas Gulf Coast. The nature of the path of the hurricane, with multiple landfalls along the Texas Gulf Coast, resulted in the largest aerial mosquito control effort for one single storm. Two mosquito control contractors and the Air Force Aerial Spray Unit of the US Air Force Reserve were used to aerial treat 6,765,971 acres (3,075,441 ha) in 29 of the 60 disaster-declared counties in Texas. During the response, 101,253 liters of Dibrom® (active ingredient [AI]: naled) and 48,735 liters of Duet™ (AI: 1% prallethrin and 5% sumithrin) were used. In 23/29 counties requesting aerial spraying, mosquito control contractors were used to conduct pre- and postaerial application mosquito surveillance. The remaining 6 counties conducted their own surveillance during the response. A total of 105,153 mosquitoes in 7 genera and 35 species were collected during this response with the major floodwater nuisance mosquito being Psorophora columbiae. The most abundant vector mosquito collected was Culex nigripalpus. Duet at the 0.8% and 1% application rates resulted in 49% and 69% control of Ps. columbiae, respectively. Dibrom application resulted in 95% and 93% control of Ps. Columbia and Cx. nigripalpus populations, respectively.
|
2022-09-28T13:59:00.472Z
|
13,717,033 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1021/JP507238U",
"MAG": "2312233234",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
We contrast the performance of monolayer electrodes and thin porous film electrodes of highly reduced functionalized graphene to demonstrate that the introduction of electrode porosity gives rise to strong apparent electrocatalytic effects resulting in vastly improved electrode selectivity. This is despite graphene showing no intrinsic advantage over glassy carbon electrodes when used as a monolayer. The simultaneous electro-oxidation of ascorbic acid, dopamine, and uric acid is used as an experimental model electrolyte system. Our results suggest that a large number of reports claiming the superior surface chemistry of carbon nanomaterials as the reason for outstanding electrochemical characteristics should be revisited considering electrode morphology as a significant contributor to the observed behavior. Our experimental results are supported by numerical simulations explaining the porosity-induced electrode selectivity by the dominance of pore depletion over diffusion-limited currents.
|
2022-12-07T22:39:41.326Z
|
45,493,264 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2190/NS.20.2.b",
"MAG": "2083289950",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Exploitation of workers and communities based on class and race has profoundly influenced occupational and environmental health. During production and testing of nuclear weapons in the United States, class and race have affected exposures to radiation and other hazards as well as protection programs and monitoring of exposures. This situation has contributed to health disparities and has hindered advancement of research into the health effects of ionizing radiation and other exposures from nuclear weapons production. Organizing by workers and affected communities can bring about a better understanding of the health effects of ionizing radiation as well as more ethical research practices.
|
2022-12-12T06:08:40.656Z
|
235,234,321 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5220/0010381000810090",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBYNCND",
"status": "HYBRID",
"url": "https://doi.org/10.5220/0010381000810090"
}
|
: Visual saliency refers to the part of the visual scene in which the subject’s gaze is focused, allowing significant applications in various fields including automotive. Indeed, the car driver decides to focus on specific objects rather than others by deterministic brain-driven saliency mechanisms inherent perceptual activity. In the automotive industry, vision saliency estimation is one of the most common technologies in Advanced Driver Assistant Systems (ADAS). In this work, we proposed an intelligent system consisting of: (1) an ad-hoc Non-Local Semantic Segmentation Deep Network to process the frames captured by automotive-grade camera device placed outside the car, (2) an innovative bio-sensor to perform car driver PhotoPlethysmoGraphy (PPG) signal sampling for monitoring related drowsiness and, (3) ad-hoc designed 1D Temporal Deep Convolutional Network designed to classify the so collected PPG time-series providing an assessment of the driver attention level. A downstream check-block verifies if the car driver attention level is adequate for the saliency-based scene classification. Our approach is extensively evaluated on DH1FK dataset, and experimental results show the effectiveness of the proposed pipeline.
|
2022-12-03T06:16:18.627Z
|
186,370,179 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.9785/GPR-2018-150609",
"MAG": "2904263063",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Der Begriff „Umgangsrecht“ nach Art. 1 Abs. 2 Buchst. a sowie nach Art. 2 Nrn. 7 und 10 der Verordnung (EG) Nr. 2201/2003 vom 27.11.2003 über die Zuständigkeit und die Anerkennung und Vollstreckung von Entscheidungen in Ehesachen und in Verfahren betreffend die elterliche Verantwortung und zur Aufhebung der Verordnung (EG) Nr. 1347/2000 ist dahin auszulegen, dass er das Umgangsrecht der Großeltern mit ihren Enkelkindern umfasst.
|
2022-01-24T22:33:40.665Z
|
193,981,217 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1177/030751331700400133",
"MAG": "2789430655",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
IN the last issue of this Journal it was my privilege to describe a fine head in obsidian of Amenemmes I I I as an elderly man. Perhaps no other Egyptian monarch has come down to us illustrated by so convincing and varied a set of portraits. With other kings, Tuthmosis.III for instance, we feel that we have seen them but once, their offigies differing only in scale and workmanship. The vivid and varying representations of Akhnaton, of a necessity, represent a young man only, owing to his short life; he is aged and altered only in his mask at Cairo, and perhaps in a coarse sandstone head of provincial workmanship, greatly weather-beaten, in the same museum. Of Ramesses I I tho Turin statue, the Colossi at Abu Simbel and Memphis, repeat the beauty of the son of the beautiful Sethos I ; in none of his portraits is there a sign of age or mood and, in all cases, the idealizing tendencies record a youth or king more than half divine. I t is the characteristic of the head of Amenemmes I I I here reproduced (Pis. X X X I X , X L ) that all attempt at idealization is absent; we have an everyday aspect, as it were, of a monarch whose other portraits express meditation, severity, great energy controlled by thought and an ever conscious sense of kingship. The exquisite seated sandstone statue of Amenemmes I I I at Cairo is singular in its delicacy of expression ; the droop of tho lids, the firm chin and lips recall the most tender Tuscan carving of the 15th century. Tho body, narrow of shoulder, is not of exceptional quality, the legs and feet aro poor and unfinished, without impairing, however, the"effect of delicate austerity of the whole; on the chest rests an amulet like two petals parted by a touch. In the superb walking statue at Berlin, the king is short, slight in shoulder, and the effect is one of gravity and watchfulness, suppressed energy and a sort of Caesar-like nobility. Other effigies—excepting tho Hyksos Lions, all grave majesty and upward energy of glance—underline something bitter and determined, for instance the fine Berlin head and the Petrogjad seated statuette. This character is yet more marked in an almost uncanny head in basalt (Cairo, No. 1368), in the catalogue only tentatively described as " a king"; there a touch of ferocity has supervened upon the leonine countenance of Amenemmes I I I .
|
2022-01-27T16:14:36.022Z
|
234,734,876 |
{
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"ACL": null,
"ArXiv": null,
"DOI": "10.25258/IJDDT.10.2.17",
"MAG": "3122576543",
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},
"license": null,
"status": null,
"url": null
}
|
Aim: Lycopene is owned to carotenoids that manifest better pharmacological possessions such as antioxidant, anti-inflammatory, and anticancer. As an outcome of very little water solubility, it has a restricted systemic absorption after oral route. Methods: Lycopene-loaded sentinel lymph nodes (SLNs) by hot homogenization method, using some alteration were formulated. The size of nanoparticles (NPs) was characterized using scanning electron microscope (SEM). Also, encapsulation efficiency, drug loading (DL), and drug release were calculated. Results: SEM revealed spherical SLNs. High EE and DL were procured. Conclusion: We formulated a stable lycopene-SLNs with better physicochemical properties.
|
2022-01-27T08:19:23.209Z
|
245,839,071 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1145/3469877.3490578",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
Colored Point Cloud (CPC) is often distorted in the processes of its acquisition, processing, and compression, so reliable quality assessment metrics are required to estimate the perception of distortion of CPC. We propose a Full-reference Quality Metric for colored point cloud based on Graph signal features and Color features (FQM-GC). For geometric distortion, the normal and coordinate information of the sub-clouds divided via geometric segmentation is used to construct their underlying graphs, then, the geometric structure features are extracted. For color distortion, the corresponding color statistical features are extracted from regions divided with color attribution. Meanwhile, the color features of different regions are weighted to simulate the visual masking effect. Finally, all the extracted features are formed into a feature vector to estimate the quality of CPCs. Experimental results on three databases (CPCD2.0, IRPC and SJTU-PCQA) show that the proposed metric FQM-GC is more consistent with human visual perception.
|
2022-05-13T13:53:21.156Z
|
3,074,281 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/PIMRC.2010.5671698",
"MAG": "2018648200",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In this paper, we propose a 2 × 2 cooperative multiple-input multiple-output (MIMO) orthogonal frequency-division multiplexing (OFDM) scheme based on Alamouti space-time coding. In this scheme, the the relay and the destination antennas receive the transmitted symbols from the source during the first stage. Then, both the relay and the destination generate their own decision variables using an Alamouti decoding procedure by the end of the first stage. In the second stage, the relay sends its own decision variables to the destination to enhance the destination decision variables and therefore improves the performance of the system. Our results show the superiority of the proposed cooperative Alamouti scheme by improving the system performance in terms of average BER, frame error rate (FER), and spectral efficiency.
|
2022-09-03T06:32:08.089Z
|
3,405,612 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/j.1743-6109.2009.01276.x",
"MAG": "2554366745",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
INTRODUCTION
The main functional factors related to lifelong premature ejaculation (PE) etiology have been suggested to be penile hypersensitivity, greater cortical penile representation, and disturbance of central serotoninergic neurotransmission.
AIMS
To quantitatively assess penile sensory thresholds in European Caucasian patients with lifelong PE using the Genito-Sensory Analyzer (GSA, Medoc, Ramat Yishai, Israel) as compared with those of an age-comparable sample of volunteers without any ejaculatory compliant.
METHODS
Forty-two consecutive right-handed, fully potent patients with lifelong PE and 41 right-handed, fully potent, age-comparable volunteers with normal ejaculatory function were enrolled. Each man was assessed via comprehensive medical and sexual history; detailed physical examination; subjective scoring of sexual symptoms with the International Index of Erectile Function; and four consecutive measurements of intravaginal ejaculatory latency time with the stopwatch method. All men completed a detailed genital sensory evaluation using the GSA; thermal and vibratory sensation thresholds were computed at the pulp of the right index finger, and lateral aspect of penile shaft and glans, bilaterally.
MAIN OUTCOME MEASURES
Comparing quantitatively assessed penile thermal and vibratory sensory thresholds between men with lifelong PE and controls without any ejaculatory compliant.
RESULTS
Patients showed significantly higher (P < 0.001) thresholds at the right index finger but similar penile and glans thresholds for warm sensation as compared with controls. Cold sensation thresholds were not significantly different between groups at the right index finger or penile shaft, but glans thresholds for cold sensation were bilaterally significantly lower (P = 0.01) in patients. Patients showed significantly higher (all P < or = 0.04) vibratory sensation thresholds for right index finger, penile shaft, and glans, bilaterally, as compared with controls.
CONCLUSIONS
Quantitative sensory testing analysis suggests that patients with lifelong PE might have a hypo- rather than hypersensitivity profile in terms of peripheral sensory thresholds. The peripheral neuropathophysiology of lifelong PE remains to be clarified.
|
2022-12-14T20:50:00.558Z
|
125,858,837 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/10407782.2017.1309217",
"MAG": "2613650392",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
ABSTRACT Electrowetting-induced microwater droplet transports in parallel-plate and open-plate electrowetting-on-dielectrode (EWOD) have been studied numerically. The governing equations for three-dimensional transient microfluidic flow are solved by a finite volume scheme with a two-step projection method on a fixed computational domain. The free surface of the droplet is tracked by the coupled level set and volume-of-fluid (CLSVOF) method with the surface tension force determined by the continuum surface force (CSF) model. The results of the numerical model have been validated with published experimental data and the physics of droplet transport have been investigated. A parametric study has been performed in which the effects of voltage amplitude, channel gap, and electrode size have been examined.
|
2022-12-19T18:20:51.077Z
|
122,005,391 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2514/3.28435",
"MAG": "2041922245",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In summary then, man-rating is emphasized as those elements of today's state of the art such as: 1) part or component traceability to insure design integrity, reliability, and configuration control; 2) extra care in the design and manufacture of equipment; and 3) an explanation of all the anomalies in the handling and testing of the equipment in component, subsystem, or total system form; and, in addition, a design for which possible malfunctions have been assessed and in which the pilot is given alternate choices in both mission and equipment so that his judgments are brought to assist in the performance of the mission. He is given a guidance and control capability (possibly coupled with a thrust control capability), a malfunction detection system, margins of safety that are consistent with the degree of risk and his speed of reaction, and a design where no single cause is likely to result in a catastrophic system failure. He has a vehicle that has been flight tested in the design conditions.
|
2022-01-27T10:02:33.013Z
|
36,015,860 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/SDPC.2017.120",
"MAG": "2774068958",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The presence of periodical impulses in vibration signals usually indicates the occurrence of faults in mechanical systems. Unfortunately, in the working condition, detecting the faults in mechanical systems is a difficult job because they are rather weak and often interfered by heavy noise. Therefore, noise suppression is one of the most important tasks in the fault diagnosis for mechanical systems. We proposed a Walsh transform (WT) based method to de-noise the noisy vibration signals. The WT could decompose a noisy signal into a set of rectangular waveforms which are called Walsh coefficients. After filter these coefficients with thresholdings, we reconstruct the signal though inverse Walsh transform (IWT). Finally, the simulation and experimental investigations of the compound faults in roller bearings are implemented to illustrate the feasibility of the WT method.
|
2022-02-12T08:01:51.134Z
|
199,608,847 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4067/S0717-95022019000301172",
"MAG": "2964077911",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The morphological and histological structure of the brains of Bufo gargarizans and Cynops orientalis were observed by anatomy and light microscopy. The results show that the brains of Bufo gargarizans and Cynops orientalis are divided into 5 parts which include the telencephalon, diencephalon, mesencephalon, cerebellum and medulla oblongata. The telencephalon consists of t he olfactory bulb and the cerebral hemisphere. The olfactory bulb is developed that has two pairs of olfactory nerve. Bufo gargarizan has a symmetrical oval hemisphere optic lobes; Cynops orientalis only has a spherical optic lobe. The cerebellum is situated behind the optic lobe and closely connected with the myelencephalon. In this paper, the morphological and histological differences between the t wo species are discussed. The proportion of cerebral hemisphere is gradually increasing, which correlated with a progressive incre ase n the number of neuronal cell classes, and reflected in behavior complexity.
|
2022-05-20T07:20:43.345Z
|
121,913,995 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1117/12.2040322",
"MAG": "2032900146",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Toward improving early detection of melanoma by accurate diagnosis and avoidance of unnecessary surgical excisions of common moles, we are developing noninvasive quantitative spectral fingerprinting of protein expression using Raman spectroscopy within confocally gated volumes of tissue. Our first target is the L-tryptophan catabolism pathway, which is unregulated in the tumor micro-environment and inhibits the immune response that usually is tumor suppressive. The tryptophan pathway is therefore worthy of diagnostic measurement and finding the ratio of L-tryptophan to its metabolites may aid a melanoma diagnosis. We report the intensity of the Raman signal from L-tryptophan and quinolinic acid, which are found during different stages of the tryptophan metabolic pathway.
|
2022-02-09T19:41:56.250Z
|
253,958,577 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1079/cabicompendium.55015",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This datasheet on Trochosa ruricola covers Identity, Distribution.
|
2022-11-26T18:41:55.266Z
|
17,164,320 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1371/journal.pone.0004518",
"MAG": "2080882235",
"PubMedCentral": "2641017"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0004518&type=printable"
}
|
Targeted disruption of murine Cdk2ap1, an inhibitor of CDK2 function and hence G1/S transition, results in the embryonic lethality with a high penetration rate. Detailed timed pregnancy analysis of embryos showed that the lethality occurred between embryonic day 3.5 pc and 5.5 pc, a period of implantation and early development of implanted embryos. Two homozygous knockout mice that survived to term showed identical craniofacial defect, including a short snout and a round forehead. Examination of craniofacial morphology by measuring Snout Length (SL) vs. Face Width (FW) showed that the Cdk2ap1+/− mice were born with a reduced SL/FW ratio compared to the Cdk2ap1+/+ and the reduction was more pronounced in Cdk2ap1−/− mice. A transgenic rescue of the lethality was attempted by crossing Cdk2ap1+/− animals with K14-Cdk2ap1 transgenic mice. Resulting Cdk2ap1+/−:K14-Cdk2ap1 transgenic mice showed an improved incidence of full term animals (16.7% from 0.5%) on a Cdk2ap1−/− background. Transgenic expression of Cdk2ap1 in Cdk2ap1−/−:K14-Cdk2ap1 animals restored SL/FW ratio to the level of Cdk2ap1+/−:K14-Cdk2ap1 mice, but not to that of the Cdk2ap1+/+:K14-Cdk2ap1 mice. Teratoma formation analysis using mESCs showed an abrogated in vivo pluripotency of Cdk2ap1−/− mESCs towards a restricted mesoderm lineage specification. This study demonstrates that Cdk2ap1 plays an essential role in the early stage of embryogenesis and has a potential role during craniofacial morphogenesis.
|
2022-12-11T17:38:57.314Z
|
123,832,206 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4153/CJM-1969-148-5",
"MAG": "2317513063",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Throughout this paper, Z is the ring of integers, ƒ*(t) (ƒ(t)) is an integer monic (co-monic) polynomial in the indeterminate t (i.e., each coefficient of ƒ* (ƒ) is in Z and its highest (lowest) coefficient is 1 (5, p. 121, Definition) and M* (M) is the multiplicative semigroup of all integer monic (co-monic) polynomials ƒ* (ƒ) having no constant term. In (3, Theorem 2), Herstein proved that if R is a division ring with centre C such that 1 then R = C. In this paper we seek a generalization of Herstein's result to semi-simple rings. We also study the following condition: (1)* Our results are quite complete for a semi-simple ring R in which there exists a bound for the codegree ofƒ (ƒ*) (i.e., the degree of the lowest monomial of ƒ(ƒ*)) appearing in the left-hand side of (1) ((1)*).
|
2022-12-15T04:41:07.881Z
|
20,973,345 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1128/AAC.39.2.301",
"MAG": "2103643813",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A series of polymer-bound antimicrobial peptides was prepared, and the peptides were tested for their antimicrobial activities. The immobilized peptides were prepared by a strategy that used solid-phase peptide synthesis that linked the carboxy-terminal amino acid with an ethylenediamine-modified polyamide resin (PepsynK). The acid-stable, permanent amide bond between the support and the nascent peptide renders the peptide resistant to cleavage from the support during the final acid-catalyzed deprotection step in the synthesis. Select immobilized peptides containing amino acid sequences that ranged from the naturally occurring magainin to simpler synthetic sequences with idealized secondary structures were excellent antimicrobial agents against several organisms. The immobilized peptides typically reduced the number of viable cells by > or = 5 log units. We show that the reduction in cell numbers cannot be explained by the action of a soluble component. We observed no leached or hydrolyzed peptide from the resin, nor did we observe any antimicrobial activity in soluble extracts from the immobilized peptide. The immobilized peptides were washed and reused for repeated microbial contact and killing. These results suggest that the surface actions by magainins and structurally related antimicrobial peptides are sufficient for their lethal activities.
|
2022-12-30T00:46:09.046Z
|
93,884,007 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1246/BCSJ.52.49",
"MAG": "1983338205",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The crystal structure of 5-bromocytosfne has been determined by X-ray analysis to investigate the bromination effect on the cytosine moiety. The space group is P21/a, with dimensions a=16.943(2), b=9.155(1), c=3.846(1) A, β=99.89(1)°, and Z=4, The structure was solved by the heavy-atom method and refined by the full-matrix least-squares method. A comparison with the cytosine structure indicates some large deviations in bond lengths and angles, which are attributed to the steric and electronic effects caused by bromination. After the VSEPR theory, the slight increase of C(2)–N(3)–C(4) angle (0.8°) is interpreted as the decrease of the effective charge of the lone pair on N(3), and this is related to the difference of pKa values between 5-bromocytosine and cytosine.
|
2022-02-10T16:41:06.959Z
|
126,268,164 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.24200/SCI.2017.4576",
"MAG": "2770465315",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Online Social Networks (OSNs) are very popular and users share various information in these networks. To protect these resources from unauthorized accesses, these frameworks must support flexible access control mechanisms. Semantic technology provides new opportunities for this purpose. This paper proposes a Prioritized Ontology. Based Access Control (POBAC) model for protecting users' information in OSNs.......
|
2022-02-09T16:21:25.940Z
|
153,506,785 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1017/S0305741000051900",
"MAG": "2037375209",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Secondly, the authors discuss why China appears to be raising its defence budget so dramatically, noting such factors as China's changing military doctrine, the lessons of the Gulf War, the rising influence of the PLA in domestic politics and regional ambitions. While all these motivations are probably valid, the authors resort here to a "kitchen sink" approach of simply listing several likely determinants without providing any assessment of which might be the most critical drivers of increased defence spending. More egregiously, they ignore completely the consideration that inflation (which reached over 20 per cent in China in the early 1990s) probably ate up much of these increases. Finally, the authors attempt to analyse the impact that China's arms build-up may have on security in the Asia-Pacific region. The arguments in this section, while interesting, are almost totally unrelated to the earlier discussion of Chinese military expenditure, however. In fact, the authors fail to make a persuasive argument linking a supposedly increasing (and larger-than-officially-declared) Chinese defence budget with how this might affect regional security. That is because such an assessment requires much more than simply looking at top-line budget figures. For budgetary data to reveal anything really useful about PLA strategic intentions and potential military capabilities, much more detailed information is needed as to long-term Chinese R&D and procurement spending plans, expenditures for operations and maintenance, and so on. Having said all that, this report does make a very important contribution in at least one respect: it argues convincingly that the Chinese grossly under-represent their actual defence budgets. That in turn raises considerable doubts as to how much we can trust China's leaders when it comes to other regional security concerns (such as Taiwan). Moreover, as studies such as these proliferate, it increases the pressure on the Chinese to come clean as to their true military expenditures.
|
2022-03-11T04:48:13.092Z
|