Hennara/MedRAG_contents · Datasets at Hugging Face

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01abd50a-1e57-44bb-9168-3f85052772c4	1	-8.5). The recovery of contractile force was three times more pH-sensitive than force decay. Under slow pacing (12/min) at +12 degrees C there was almost complete recovery to control values within 60 min at pHe above 7.0. Under this pH level recovery was largely delayed (pH 6.5
01abd50a-1e57-44bb-9168-3f85052772c4	2	) or did not occur (pH 6.0). Prolongation of contraction during the reoxygenation phase, observed at low H ion concentrations, was largely delayed or absent under high concentrations of H ions.
a7f98d41-4470-46a5-85d0-7f7ab588d001	0	Effect of variations in pH on kinetics of myosin. The pH optimum was the same in canine tissue for cardiac and skeletal muscle myosin; when myosin was activated by monovalent cations, the pH optimum was 7.5 while activation of myosin by divalent cations gave a pH optimum of 5.5
a7f98d41-4470-46a5-85d0-7f7ab588d001	1	. Protons were needed for divalent cation activation of myosin. With changes in pH there were concomitant changes in the apparent affinity of enzyme for substrate (S 0.5), such that with a decrease in pH there was an elevation in K+- or NH4+ -activated myosin's apparent affinity for adenosine triphosphate (ATP), and at the same time a decrease in Vmax values of myosin.
a7f98d41-4470-46a5-85d0-7f7ab588d001	2	The converse was true with the divalent cations, Ca++ and Mn++; here with a decrease in pH there was a concomitant decrease in apparent affinity of myosin for ATP, and at the same time an increase in the enzymatic Vmax values. It appeared that hydrogen ions affected the apparent affinity of myosin for substrate and this in turn affected the rate-limiting step in ATPase reaction.
a7f98d41-4470-46a5-85d0-7f7ab588d001	3	Addition of monovalent cations to the divalent cation activating system lowered the activity of myosin, and the converse was true: divalent cations lowered the activity of myosin when activated by monovalent ones in a monovalent cation activating system.
5d6c0d06-393f-4d34-a0dd-ef501e04339b	0	Distribution of prostaglandin E 9-ketoreductase and NAD+-dependent and NADP+-dependent 15-hydroxyprostaglandin dehydrogenase in the renal cortex and medulla of various species. Regional distributions of PGE 9-ketoreductase and 15-hydroxy-prostaglandin dehydrogenase were examined in the cytoplasmic fractions from the kidneys of seven species. All species contained an NADPH-dependent reductase, as well as NAD+- and NADP+-dependent dehydrogenases in both cortex and medulla.
5d6c0d06-393f-4d34-a0dd-ef501e04339b	1	A previously unrecognized cytoplasmic NADH-dependent PGE 9-ketoreductase was also detected in the cortex and medulla of rat and bovine kidney. Total NAD+- and NADP+-dependent dehydrogenase activity was about equally distributed between the two renal regions of monkey, dog, rat, and swine. Bovine, rabbit, and cat had greater cortical than medullary dehydrogenase activity with ratios of 3, 5, and 10 respectively.
5d6c0d06-393f-4d34-a0dd-ef501e04339b	2	The activities of NAD+- and NADP+-dependent dehydrogenase varied among the renal tissues.
eedbd944-c965-4ea9-9977-8404caa7fdd9	0	Normal blood-gas values in lambs during neonatal development and in adult sheep. Arterial oxygen (PaO2) and carbon dioxide (PaCO2) tensions and pH were determined in 20 lambs during development from two weeks to five months of age and in 34 adult sheep. Throughout the period the lambs' mean PaCO2 (33.1
eedbd944-c965-4ea9-9977-8404caa7fdd9	1	mm Hg) and pH (7.46) values were similar to those determined in the adult sheep (PaCO232.1 mm Hg; pH 7.48). The lamb's mean PaO2 increased from 63.3 mm Hg at two weeks of age to about 80 mm Hg at eight weeks and by 20 weeks was similar to the mean PaO2 (88.0
eedbd944-c965-4ea9-9977-8404caa7fdd9	2	mm Hg) of adult sheep.
b9537704-6d31-4c41-ba75-4b20f2d0672b	0	[The clinical importance of angiography in the diagnosis of periarteritis nodosa]. Report on a 53 years old patient with renal failure. Angiography showed multiple micro-aneurysms in kidneys and liver, in some instances also in the pancreatic, duodenal and mesenterial arteries. Muscle biopsy confirmed the suspicion of arteriitis nodosa. Clinically the diagnosis of necrotizing arteriitis is difficult. Angiography settles the diagnosis, but only positive findings of micro-aneurysms prove it. The differential diagnosis is discussed and illustrated.
bbbbd0a9-136e-49c8-8906-59ab032d039f	0	pH and the cytotoxicity of fluoride in an animal cell culture system. To investigate the mechanism for the toxicity of silicate cement as observed in a cell culture system, the effects of pH and fluoride were tested on human epithelial cells (NCTC 2544). At pH 7.3, fluoride concentrations from 15 to 25 mug/ml (0.79
bbbbd0a9-136e-49c8-8906-59ab032d039f	1	to 1.3 mM) had a growth inhibitory effect. When pH of the incubation medium was lowered in the range 7.0 to 6.4, an enhanced cytoxic effect of fluoride was found, and even at 5 to 10 mug/ml growth inhibition occurred. Concomitant with the enhanced cytotoxicity of fluoride at low pH, there was an increased utilization of glucose and formation of lactate.
bbbbd0a9-136e-49c8-8906-59ab032d039f	2	Upon lowering the pH of the incubation medium from 7.4 to 6.7 a twofold increase in the intracellular concentration of fluoride was found.
56ca42f7-c2ed-4cc7-be5d-91fac7aab5a9	0	Dysplasia of the testis and epididymis. Various congenital malformations of the testis and the seminal pathways are illustrated by 10 cases. Though these malformations are often free from symptoms, an increasing number of them are now being discovered in connection with investigations of male infertility. In cases of azoospermia where testicular biopsies show complete spermatogenesis, surgical exploration is indicated. Some of these malformations may then be treated by surgery, with fairly good prospects of restored fertility.
5633524c-06c3-495b-8a83-d61f09f9d759	0	[Lipoprotein X in hepatobiliary diseases]. The diagnostic and prognostic reliability of lipoprotein-X (Lp-X) in demonstrating or ruling out cholestasis has been evaluated in a group of 80 patients with diseases of the liver and/or the biliary tracts, and in 103 subjects with various other diseases.
5633524c-06c3-495b-8a83-d61f09f9d759	1	The results of Lp-X detection were compared with the so-called "enzymes indicating cholestasis": alkaline phosphatase, leucine arylamidase, and gamma-glutamyltranspeptidase. Where possible a histologic specimen of the liver was obtained. The correlation between Lp-X and "enzymes indicating cholestasis" was satisfactory in more than 90% of cases.
5633524c-06c3-495b-8a83-d61f09f9d759	2	When compared with the histologic findings, Lp-X proved to be more reliable than the enzymes. Despite this fact, Lp-X did not show absolute specifity in the detection of cholestasis as there were several negative results in cases with histologically proven cholestasis. Furthermore, the differentiation of intra- and extrahepatic cholestasis was not possible on the basis of Lp-X.
5633524c-06c3-495b-8a83-d61f09f9d759	3	In the control group of 103 patients with other than hepatobiliary diseases, a positive Lp-X result was found in 3 cases. Further investigations in these three patients revealed that primarily unsuspected hepatobiliary disease could not be ruled out. In the follow-up of a hepatobiliary disease the transition of Lp-X to negative indicates a trend towards improvement of cholestasis 1-2 weeks earlier than the enzymes mentioned above.
19337b7e-ed1c-427c-a237-81ae7f98f12c	0	[Proceedings: Home treatment of chronic respiratory insufficiency: inhalation of beta stimulators]. In the author's experience, the longterm treatment of chronic obstructive lung disease should be supplemented by continuous selective stimulation of the adrenergic beta-receptors in the smooth bronchial muscles. The following procedure is recommended: inhalation of 15 min 3 times daily using an adequate aerosol with a powered nebulizer (Pari-Privat), with 2-3 ml Tyloxapol carrier solution or saline with 5 drops salbutamol.
85b038f3-8407-4c17-b719-1dcebb521871	0	[Proceedings: Long-term therapy with antibiotics in chronic bronchitis]. Longterm therapy of chronic bacterial bronchitis assumes two forms: (a) therapy of acute exacerbations, and (b) continuous longterm prophylaxis, chiefly during the 4-7 winter months. Longterm prophylaxis should be confined exclusively to patients with two or more severe annual exacerbations. The commonest pathogens, Haemophilus influenzae and pneumococci, are usually sensitive to ampicillin and amoxycillin, cotrimoxazole (Bactrim or Eusaprim) and tetracyclines.
83572523-6b5c-4afc-bcf4-32cc80f618e0	0	[Isolation, identification and quantitative determination of lysolecithin in the human gastric juice]. Lysolecithin was isolated and identified from the gastric contents of 5 patients with gastric ulcer and erosive and atrophic gastritis. The methods used involved methanolic extration, column chromatography on silica gel and sephadex gel filtration, followed by preparative thin layer chromatography.
83572523-6b5c-4afc-bcf4-32cc80f618e0	1	Identification of lysolecithin was verified in one sample by thin layer chromatography and elementary analysis. A method for quantitation of lysolecithin in human gastric fluid for routine clinical analysis is described, based on the procedure used for identification of this phospholipid. Further, a hemolysis test is proposed for screening gastric contents for lysolecithin concentrations above approximately 10 mg/100 ml.
83572523-6b5c-4afc-bcf4-32cc80f618e0	2	With the quantitative method, an average concentration of 66.1 mg of lysolecithin in 100 ml gastric content was found in the group of 5 patients. The screening test was positive in all 5 samples, but was negative with native gastric juice in 25 persons serving as controls. When the gastric fluid of the controls was concentrated, however, 9 samples gave a positive hemolytic reaction.
83572523-6b5c-4afc-bcf4-32cc80f618e0	3	From these 9 specimens, the lysolecithin concentration was found to average 0.9 mg/100 ml. These findings afford evidence that lysolecithin may be involved as a factor in the pathogenesis of gastric ulceration.
32001cd8-c208-423f-a057-ec904b07a84a	0	[Prinzmetal angina: clinical aspects and coronarographic findings]. The clinical course and coronary arteriographic findings in 5 patients with Prinzmetal's variant angina pectoris are reviewed. In 4 patients who had ST-elevations inferiorly, 1 had minimal, 1 only slight, and 1 medium coronary artery disease; 1 had coronary spasm.
32001cd8-c208-423f-a057-ec904b07a84a	1	1 patient with ST-elevation anteriorly had severe stenosis of the anterior descending coronary artery. All 5 patients had normal left ventriculograms, 3 also had normal left enddiastolic pressure, and 2 slight elevation. Medical treatment was carried out in 2 patients and surgical revascularization in 2. Both treatments were accompanied by marked symptomatic improvement.
32001cd8-c208-423f-a057-ec904b07a84a	2	Spontaneous loss of angina occurred in 1 patient. Prinzmetal's variant angina pectoris may be accompanied by a variety of coronary arteriographic findings and the prognosis appears to be more favorable than previously reported.
02504654-edda-4026-abc1-19fe3f5c9b14	0	[Forms of so-called crytorchism. Studies on 579 patients]. In a material of 579 patients the incidence of the different forms of cryptorchism is investigated. The findings reveal retractile testes in 16.4%, ectopic testes in 23.1%, inguinal retentions in 49.5%, abdominal retentions in 2.3% secondary cryptorchism in 3.5%, and monorchism and anorchism in 4.9%. These results are compared with those of other authors.
f55bd814-6c51-4509-849e-cb86cc6301c1	0	[Sugar-free, tooth-protecting chewing gum and candy. Results of a 7-year study]. Experiences of 7 years with sugarless chewing gums and lozenges (tab. I and II) regarding their tooth protective properties are reported. Telemetry of interproximal plaque pH allows to assess acid formation from carbohydrates by plaque bacteria under almost natural conditions.
f55bd814-6c51-4509-849e-cb86cc6301c1	1	Altogether, 5 chewing gums and 8 lozenges containing sorbitol or mixtures of sorbitol and hydrogenated oligosaccharides were investigated. Lowest pH values during and after chewing sugarless gums varied between pH 6.0 and 7.3. When sucking sugarless lozenges the recorded pH values were between 5.8 and 7.0. In contrast to lozenges, the consumption of sugarless chewing gums becomes particularly important due to their greater stimulation of saliva and buffering capacity of oral fluid.
f55bd814-6c51-4509-849e-cb86cc6301c1	2	All products tested did not acidify interproximal plaque below the critical pH and therefore comply with the regulations of the Swiss Federal Health Authorities with respect to the labeling or marketed sweets with "safe for teeth". New non-fermentable sugar-replacing substrates are being developed. Their utilization in foodstuffs and sweets is being discussed.
b5d1476d-3f01-43ed-a42d-c6320803e262	0	[Churg-Strauss syndrome. Its nosological place. Apropos of a new case diagnosed before death]. Allergic granulomatous angeitis or Churg and Strauss disease, seems to form part of the disease of necrotising angeitis. Clinically, it may be considered when periarteritis nodosa is associated with asthma and marked eosinophilia.
b5d1476d-3f01-43ed-a42d-c6320803e262	1	The diagnosis depends on the pathological findings including the venous and pulmonary lesions, giant cells and the presence of extra-vascular granulomas. The recognition of this disease does not, however, permit one to give a precise prognosis. In the absence of progress concerning the pathogenesis, treatment will be the same as that given in other forms of necrotising angeitis.
19c0bd51-9df2-4b96-be01-d99074e06e42	0	[Periarteritis nodosa and cancer. Apropos of 2 cases]. The authors report two cases of periarteritis nodosa associated with carcinoma. The first case was a man with an anaplastic bronchial carcinoma, the second was a woman with a rectal adenocarcinoma. Study of the association of certain collagen diseases with carcinoma was made to emphasize the great rareness of this association.
794eb874-a87c-4f2a-9677-dbdc76b4c621	0	Nonsurgical control of massive acute gastric mucosal hemorrhage with antacid neutralization of gastric content. A simple and safe method of medical treatment for control of massive acute gastric mucosal hemorrhage is described. The procedure was developed from the observation that gastric HCl played a central role in peretuating the syndrome.
794eb874-a87c-4f2a-9677-dbdc76b4c621	1	The treatment consists in neutralization of the gastric acid with antacid to pH of 7.0. In preliminary observations of consecutive admissions, 19 of 20 (95 per cent) patients treated with this techinique stopped bleeding. The one remaining patient required surgery. There were no deaths. In contrast, 10 of 15 (66 per cent) patients stopped bleeding with conventional medical therapy.
794eb874-a87c-4f2a-9677-dbdc76b4c621	2	Four of the remaining patients required surgery to control the bleeding. One patient did not stop on medical management. All five (33 per cent) patients died.
be3982ae-9fa4-4aae-af1c-f23aab992073	0	Effect of total gastrectomy on acid proteolytic zymogens in serum and urine. Proteolytic pH-activity curve and agar gel electrophoretic pattern of acid proteolytic zymogens in serum and urine were studied in totally gastrectomized patients. In serum, total gastrectomy was found to reduce proteolytic activity markedly, but no appreciable changes could be detected by electrophoretic analysis.
be3982ae-9fa4-4aae-af1c-f23aab992073	1	In urine, however, in addition to the marked reduction of proteolytic activity, changes were found in electrophoretic pattern after total gastrectomy. Namely, fraction Pg 3 tended to persist, while Pg 5 disappeared along with the lapse of time after total gastrectomy. An unusual appearance of fraction Pg 7 in urine was also observed on the occasion of postoperative transient albuminuria.
be3982ae-9fa4-4aae-af1c-f23aab992073	2	Their orgins and related clinical problems were discussed.
6b66b4e1-6e96-4555-8108-771d1c7ab8c2	0	[Pollen diet as an adjuvans of radiotherapy in gynecologic carcinomas]. The introduction of a pollen diet as an adjuvant in the reduction of side effects during radiotherapy of patients with gynaecological cancer is described and its efficacy evaluated. 15 women with carcinoma of the cervix received a pollen diet during irradiation, whilst ten further patients receiving irradiation served as controls without pollen added to the diet.
6b66b4e1-6e96-4555-8108-771d1c7ab8c2	1	Serum enzymes, proteins, vitamins and blood count were analysed before and after irradiation. It appears, that pollen favourably influences the efficacy of irradiation and reduces the frequency of side effects, both subjectively and objectively.
5c12d6df-6ed2-4ea5-9410-d795cef3cb48	0	[Effects of lethal overexposure on gastric secretion in the pig]. The characteristics of gastric secretion following acute gamma exposure (1500 rd) were studied in pigs with a small Pavlov stomach. Spontaneous secretion was practically inhibited when the animals were taken out of the irradiation cell. It slowly recovered in the following hours and its pH, first neutral, turned acid again.
5c12d6df-6ed2-4ea5-9410-d795cef3cb48	1	However, till the third day, it did not recover normal characteristics. The excretion of sodium ions was much increased. Under histaminic stimulation, the responses of irradiated pigs and controls were much similar. The secretory capacities of the gastric mucosa were retained but without spontaneous manifestations. As a conclusion, the early troubles following overexposure must be the consequences of regulation disorders rather than of the direct action of radiation on the stomach.
b50bca87-e95e-4852-ab17-54068cdb5d7a	0	A study of the host selection patterns of the mosquitoes of the Kisumu area of Kenya. The results of 12,168 precipitin tests on blood meals of mosquitoes of the Kano Plain caught by a variety of catching techniques indicate that to gain an accurate overall picture of feeding patterns both the indoor and the outdoor biotope must be sampled.
b50bca87-e95e-4852-ab17-54068cdb5d7a	1	CDC light traps operated inside houses and Monkswood type light traps operated under the outside eaves of houses were found to collect larger numbers of blood fed specimens from a wider range of species than battery driven aspirators collecting from natural resting sites. The results indicated that 7 mosquito species entered houses to bite man in appreciable numbers in the Kisumu area.
b50bca87-e95e-4852-ab17-54068cdb5d7a	2	These were Anopheles gambiae s.l., A. funestus, A. pharoensis, Mansonia uniformia, M. africana, Culex antennatus, and C. univittatus. Eight mosquito species were found to bite man and domestic animals in the outdoor biotope in large numbers. These were: A. pharoensis, A.
b50bca87-e95e-4852-ab17-54068cdb5d7a	3	ziemanni, M. uniformis, M. africana, C. antennatus, C. univittatus, Aedes circumluteolus, and Ae. ochraceus. From an epidemiological point of view, species with a narrow range of hosts are most likely to be of importance as vectors of parasitic diseases such as malaria and into this category fall the major man biting anophelines A.
b50bca87-e95e-4852-ab17-54068cdb5d7a	4	gambiae and A. funestus. Those mosquito species which switch from one group of hosts to another according to local circumstances are most likely to be involved in arbovirus transmission and in this group the following species must be considered: A. pharoensis, A. ziemanni, M. uniformia, M.
b50bca87-e95e-4852-ab17-54068cdb5d7a	5	africana, C. antennatus, C. univittatus and Ae. circumluteolus.
b473dd6f-36d1-45e1-88f7-204c8c9aa34b	0	The host component of the graft-versus-host reaction. A study on the popliteal lymph node reaction in the rat. I have measured the proportion of host cells in a popliteal lymph node undergoing a graft-versus-host (GVH) reaction. By using cytotoxic alloantisera with specificity for donor and host Ag-B determined antigens, it was found that about 90% of live cells suspended from the node were of host origin.
b473dd6f-36d1-45e1-88f7-204c8c9aa34b	1	The role of host T lymphocytes in this reaction was evaluated by investigating GVH-reactivity in hosts depleted of T cells (B rats). These rats differed very little from normal hosts with regard to lymph node weight increase (which was, in fact, slightly enhanced), increase in node cellularity, and donor/host contribution.
b473dd6f-36d1-45e1-88f7-204c8c9aa34b	2	The number of i.v. infused 51Cr-labelled thoracic duct lymphocytes localizing in popliteal lymph nodes undergoing a GVH-reaction was increased, but the significance of this phenomenon for the lymph node enlargement is questionable.
32b0c2f2-6edf-4490-a5fd-827226b1339e	0	Arboviruses isolated from mosquitos and man in Surinam. In the capital of Surinam, and in parts of the coastal plain and the savannah belt 47 strains of arbovirus were isolated from mosquito pools and from sentinel mice. Most of the strains (51%) were of the Mucambo type.
32b0c2f2-6edf-4490-a5fd-827226b1339e	1	The other types were Guama, Bimiti, Una, Catu, Restan, Maru, and Kwatta. Culex portesi was found to be the principal vector of all but one (Maru) types. Other vectors found to be carriers of arboviruses were Psorophora ferox, Mansonia venezuelensis, and Aëdes serratus. The highest proportion of mosquito pools yielding arboviruses was found in the savannah belt, the lowest in the municipality of Paramaribo.
65dd7e48-aedc-425f-9a52-a38d757a1450	0	The use of pluronic polyols in the precipitation of plasma proteins and its application in the preparation of plasma derivatives. Pluronic F-38 was used a precipitant of plasma proteins under varying conditions of pH and polymer concentration. Results indicated that marked differences in the solubility of the plasma proteins in F-38 solutions can be appled to the separation of plasma components.
65dd7e48-aedc-425f-9a52-a38d757a1450	1	The feasibility of the industrial application of this fractionation method was tested in several experiments. Conditions were established for the preparation of albumin, human plasma protein fraction (HPPF), and immune serum globulin (ISG) with similar yield and purity as those prepared by the Cohn methods. Current procedures for the preparation of antihemophilic A (Facor VIII) concentrate and prothrombin complex (Factors II, VII, IX, and X) were adapted to the F-38 process by removal of the clotting factors from the starting plasma prior to polymer precipitation.
65dd7e48-aedc-425f-9a52-a38d757a1450	2	In addition, a plasma protein solution free of lipoproteins, isoagglutinins, and clotting factors was developed which has proven useful as a perfusion medium in organ preservation.
55fdd265-12fc-44e6-930e-539018878026	0	Preparation and storage of platelet concentrates. A technique of platelet concentrate preparation and storage is presented which permits the maximum number of viable and functional platelets to be preserved for periods of 72 hours. Although the storage conditions must be followed precisely, the method is nevertheless simple to perform and does not require specialized expensive equipment.
55fdd265-12fc-44e6-930e-539018878026	1	Critical factors include: 1) preparation of the platelet concentrates with an initial centrifugation of 1000 X g for 9 minutes and a second centrifugation of 3000 X g for 20 minutes (86% +/- 1 platelet yield), 2) a storage bag composed of either Fenwal's PL-146 or McGaw plastic, 3) constant gentle mixing, 4) a 70 ml residual plasma volume, and 5) room temperature storage (22 C +/- 2).
55fdd265-12fc-44e6-930e-539018878026	2	In Vivo platelet recovery after 72 hours of storage at room temperature averaged 46 per cent +/- 3 and survival was 7.9 days +/- 0.3 (81% of fresh platelet viability). The function of these platelets as measured by the correlation between bleeding time and platelet count after transfusion of pooled platelets into unimmunized, aplastic thrombocytopenic recipients was as good as that of fresh platelets.
55fdd265-12fc-44e6-930e-539018878026	3	Both viability and function of concentrated platelets stored at 4 C are severely compromised.
67d1c775-a973-4a49-bbeb-f8c7fd0ab563	0	[Polysome ribonucleases of leukemic cells]. The composition of ribosomal proteins isolated from normal homopoietic and leucemic cells was studied by analytic electrophoresis in polyacrylamide gel. It was found that acid-soluble proteins from polysomal complexes can be separated into 21-22 components in the acid system. There was no significant differences in protein components from normal and leucemic polysomes by their quantity and mobility in polyacrylamide gel.
67d1c775-a973-4a49-bbeb-f8c7fd0ab563	1	Five protein components possess a ribonuclease activity as it was established by using technique of direct RNase assay in electrophoregrams. All ribonuclease-active components have pH optimum at 7.6-7.8. No differences were detected in the number and activity of particular enzyme components of polysomes isolated from normal hemopoietic and leucemic tissues.
67d1c775-a973-4a49-bbeb-f8c7fd0ab563	2	It is suggested that the number and presence of RNases in polysome complexes is likely to play not a significant role in regulation of polysome activity, but influence of inhibitors makes this supposition possible.
f55cc55f-1849-4b6c-a1c6-b6bba280f95a	0	[Comparative characteristics of catalase from the fungus Penicillium vitale, which is synthesized under different nutritional conditions]. A comparative study of properties (absorption spectra, thermostability, pH optimum, polyacrylamide gel electrophoresis, DEAE-cellulose separation) and structure (amino acid composition, finger-prints, carbohydrate composition) was performed for P.
f55cc55f-1849-4b6c-a1c6-b6bba280f95a	1	vitale catalase synthesized under different medium conditions. In all cases the results were similar. The only difference occured in the amount of synthesized proteins. A conclusion is drawn that under different nourishing conditions of the fungus the properties and structure of the catalase are unchanged, but the regulatory mechanisms of catalase and glucosooxidate synthesis undergo changes.
d1dd2a4a-930b-4d7f-9473-4e59c58adb9d	0	Suprapubic paramedian laparotomy for equine abdominal cryptorchidism. The history of techniques for abdominal equine cryptorchidectomy is briefly reviewed. The technique of suprapubic paramedian laparotomy as used since 1955 at the University of Liverpool veterinary field station is described in detail and an account given of the authors' experience with the technique in nearly 200 cases.
d1dd2a4a-930b-4d7f-9473-4e59c58adb9d	1	It is concluded that the approach to the abdominal cavity is easy, that the testis itself is generally readily located and removed and that controlled repair of the incision is possible. Serious post-operative complications are rare and the danger of post-operative prolapse of bowel eliminated.
7e0217c0-4b4e-4e61-a27b-e2f1a4878df1	0	[Bacteriological and physicochemical studies of the meat from poultry with acute Marek's disease]. Studied were bacteriologically a total of 114 birds affected with acute Marek's disease (40 broilers, 44 growing layers, and 30 adult layers) as well as 100 healthy control birds of the same three categories.
7e0217c0-4b4e-4e61-a27b-e2f1a4878df1	1	A chemical analysis was performed of the red and white meat of 20 of the diseased pullets and 20 of the diseased adult layers as well as of 34 of the affected broilers. The investigation included the same numbers of the control birds. Extractions of the sampled meat were studied in terms of catalase number, pH value, and peroxydase activity.
7e0217c0-4b4e-4e61-a27b-e2f1a4878df1	2	It was found that enterobacteria in the viscera of the diseased birds were three to nine times more frequently encountered than in the same organs of the controls. In two cases Salmonella bacteria were also isolated from the affected chickens. In three cases there were enterobacteria in the red musculature of these birds.
7e0217c0-4b4e-4e61-a27b-e2f1a4878df1	3	The meat of the diseased birds had higher water content, higher catalase number and pH value, with lower contents of proteins, fats, and mineral matter. The only exception was the red meat of these birds which had higher content of crude protein as compared with the red meat of the normal birds.
25ebb568-8f92-411f-82cb-749c9c222012	0	[The function of shuttle systems of liver extramitochondrial hydrogen transport in experimental atherosclerosis]. An enzymatic activity of shuttle systems for reduction equivalents transport (malate-aspartate, glycerophosphate, lactate, glutamate and beta-hydroxybutyrate dehydrogenase) was studied spectrophotometrically in liver tissue of intact rabbits and animals with experimental atherosclerosis.
25ebb568-8f92-411f-82cb-749c9c222012	1	Content of malate, oxaloacetate, glutamate, alpha-ketoglutarate, alpha-glycerophosphate, dihydroacetone phosphate, lactate, pyruvate, beta-hydroxybutyrate and acetoacetate were studied. In experimental atherosclerosis coordinated functioning of the enzymes, which participate in the utilization of the cytoplasmic NAD-H2 and the alteration in the ratio of reduced and oxidized metabolites in the systems, were found to be impaired.
bc21dfca-7e04-4cd3-99b7-7c75992bb674	0	[The specificity of galactokinase induction in rat liver tissue under the effect of galactose]. In liver tissue of rats, a conventional laboratory food of which was substituted for galactose-rich food, the galactokinase activity was increased, but the glucokinase was not affected. In the rats kept on a glucose-rich food the glucokinase (but not the galactokinase) was activated.
bc21dfca-7e04-4cd3-99b7-7c75992bb674	1	Hydrocortisone injection induced an increase in tyrosine aminotransferase, but the galactokinase activity was not altered. The data obtained suggest that in rat liver tissue the galactokinase was specifically induced under the effect of galactose. Except for the liver tissue, galactose induced galactokinase in eye crystalline lens; the enzyme activity was not altered in spleen and kidney.
2ab9efc2-54a7-4c5d-bb78-d2d3cd23871b	0	[Age-related properties of inductive synthesis of glucose-6-phosphatase, fructose-1,6-diphosphatase, tyrosine aminotransferase and tryptophan pyrrolase in hypothalamus stimulation]. In aged rats electrostimulation of hypothalamus caused less distinct induction of the enzymes in liver tissue, kidney and spleen as compared with the adult animals.
2ab9efc2-54a7-4c5d-bb78-d2d3cd23871b	1	The activation of the total RNA synthesis (actinomycin D and olivomycin) eliminated the alterations in the enzymatic activities, caused by the stimulation of hypothalamus. Effect of adrenalectomy and administration of ACTH suggested that the influence of the hypothalamus stimulation on induction of the enzymes studied was realized through the system hypophysis -- adrenal cortex.
2ab9efc2-54a7-4c5d-bb78-d2d3cd23871b	2	In the aged animals activation of adrenal cortex was less distinct when the stimulation of hypothalamus was carried out. The alterations in hypothalamic regulation of the enzyme induction could be an important mechanism in regulation of adaptive reactions in aged organisms.
72969800-90b2-4cbd-ad3b-0add4e909ff6	0	[Determination of the transferase activity of L-asparaginase]. A method for determination of the transferase activity of 1-asparaginase in presence of hydroxylamine is developed. The optimally determined quantity of the enzyme was from 0.7 to 20 i. u. The conditions optimal for the enzymatic reaction and for quantitative estimation of 1-aspartyl-beta-hydroxamic acid were studied. The transferase and hydrolase activities of 1-asparaginase from E. coli were compared. The enzyme catalyzed at equal rates hydrolysis and hydroxylaminolysis of 1-asparagine.
84bab98e-2a63-4fb6-8e0c-b7fa049c56b1	0	[The effect of lipids from typhoid endotoxin on the activity of some liver enzymes]. Sublethal doses of typhoid endotoxin distinctly increased the activities of glutamate dehydrogenase and histidine ammonium lyase in liver tissue of mice within 3 hrs and the tyrosine transaminase activity within 6 hrs after a single intraperitoneal administration.
84bab98e-2a63-4fb6-8e0c-b7fa049c56b1	1	Within 24 hrs normalzation of these enzyme activities and a decrease in the urocaninase activity were observed in liver tissue. Lipid A, obtained from the endotoxin, activated glutamate dehydrogenase and histidine ammonium lyase, inhibited urocaninase but did not affect the tyrosine transaminase activity. Lipid B, isolated by a non-hydrolytic method, showed even wore distinct capacity to activate glutamate dehydrogenase and histidine ammonium lyase, but did not alter the activities of tyrosine transaminase and urocaninase in liver tissue.
1c39c661-aabf-4d3f-81cd-b5bcd82036bf	0	[Purification and properties of myeloperoxidase from mice leukocytes]. Myeloperoxidase from leucocytes of peritoneal exudate was isolated by chromatography on DEAE-Sephadex, CM-cellulose and gel filtration on Sephadex G-75. The preparation obtained was homogenous as shown by repeated gel filtration and ultracentrifugation. The enzyme was purified 302-fold, with 16% yield.
1c39c661-aabf-4d3f-81cd-b5bcd82036bf	1	The sedimentation constant was equal to 4.05 S. Molecular weight of the enzyme, determined by gel filtration on Sephadex G-100, constituted 135,000 daltons. Myeloperoxidase had two pH optima of activity--at pH 4.6 and at pH 7.6. Km for o-dianizidine was equal to 4.0
1c39c661-aabf-4d3f-81cd-b5bcd82036bf	2	-10(-3)M and for hydrogen peroxide--to 1.65-10(-4)M. Myeloperoxidase of mice leucocytes differed from the enzymes of leucocytes from other animal species in its distinctly lower sedimentation constant and thermolability.
ecedc2de-3540-49df-97ee-574770e42aeb	0	[Changes in oxidative systems of liver microsomes in rats following a single administration of phenobarbital and morphine]. During the first three hours after a single administration of phenobarbital or morphine into rats a marked increase was observed in the activity and content of the respiratory chain components responsible for the oxidation of NAD-H2 and NADP-H2 in liver microsomes.
ecedc2de-3540-49df-97ee-574770e42aeb	1	This activation of oxidative enzymes correlated with the disappearance of hypnotic and analgetic effects of the narcotics. The phase following the normalization of oxydative systems was characterized by the increase of microsomal enzymes level. This is related to their specific induction only by phenobarbital.
aa3ad4fb-2833-4ff0-83b1-e55085877b6e	0	[Isolation and properties of 2 kallikreins from human saliva]. Two kallikreins (K-I and K-II) were purified from mixed, parotid and submandibular human saliva. The kallikreins were separated by chromatography on CM-cellulose. The pH optima of activity were at pH 9.3 and pH 9.6-9.8
aa3ad4fb-2833-4ff0-83b1-e55085877b6e	1	; Km for BAEE was 1.10-3M and 4.10-3M, respectively. The esterase activity of K-I and K-II was inhibited by trasylol-like inhibitors, while the plant and synthetic inhibitors of trypsin were uneffective. In dog, rabbit and rat the hypotensive effect of K-II and its action upon the permeability of rabbit skin was 4-5 fold higher than the effects of K-I.
aa3ad4fb-2833-4ff0-83b1-e55085877b6e	2	Ki and K-II did not alter the arterial blood pressure in guinea pig.
f3f03f57-a6db-4d8d-b7bf-aae9581101f2	0	[The correlation between activity of enzymes participating in the formation and utilization of acetyl CoA in rabbit heart mitochondria in myocarditis and normal state]. Activities in rabbit heart mitochondria of acetoacetyl-CoA-thyolase, pyruvate dehydrogenase, acetyl CoA-synthetase, citrate synthase and acetyl carnitine transferase were compared. These enzymes participate in formation and utilization of acetyl-CoA.
f3f03f57-a6db-4d8d-b7bf-aae9581101f2	1	The acetoacetyl-CoA-thyolase and acetyl CoA-synthetase were shown to possess the more distinct capacity in vitro to form acetyl CoA. The co-enzyme was most efficiently utilized under these experimental conditions by the citrate synthase. The enzymes studied were localized within the mitochondria fraction in both the subfractions of soluble and membrane-bound proteins.
f3f03f57-a6db-4d8d-b7bf-aae9581101f2	2	In myocarditis a distinct decrease in activities of the acetoacetyl-CoA-thyolase and citrate synthase was observed.
3500ea95-abeb-4a62-8936-5fe94c01ea13	0	[New values for the molar extinction coefficients of NADH and NADPH for the use in routine laboratories (author's transl)]. Extensive re-investigations with regard to the molar extinction coefficients of NADH and NADPH proved that in future, calculations in routine work can be performed with the following much more accurate epsilon-values:
3500ea95-abeb-4a62-8936-5fe94c01ea13	1	6.15 x 10(3) 1 x mol-1 x cm-1 at Hg 334 nm (NADH and NADPH), 6.3 X 10(3) 1 X mol-1 x cm-1 at 340 nm (NADH and NADPH), 3.4 X 10(3) 1 X mol-1 X Cm-1 (NADH) and 3.5
3500ea95-abeb-4a62-8936-5fe94c01ea13	2	x 10(3) 1 x mol-1 x cm-1 (NADPH) at Hg 365 nm, respectively. The safest measurement is performed at Hg 334 nm, because here epsilon is identical for both coenzymes and deviations of the epsilon-value caused by temperature, pH and ionic strength are less than 0.5

01abd50a-1e57-44bb-9168-3f85052772c4

1

-8.5). The recovery of contractile force was three times more pH-sensitive than force decay. Under slow pacing (12/min) at +12 degrees C there was almost complete recovery to control values within 60 min at pHe above 7.0. Under this pH level recovery was largely delayed (pH 6.5

01abd50a-1e57-44bb-9168-3f85052772c4

2

) or did not occur (pH 6.0). Prolongation of contraction during the reoxygenation phase, observed at low H ion concentrations, was largely delayed or absent under high concentrations of H ions.

a7f98d41-4470-46a5-85d0-7f7ab588d001

0

Effect of variations in pH on kinetics of myosin. The pH optimum was the same in canine tissue for cardiac and skeletal muscle myosin; when myosin was activated by monovalent cations, the pH optimum was 7.5 while activation of myosin by divalent cations gave a pH optimum of 5.5

a7f98d41-4470-46a5-85d0-7f7ab588d001

1

. Protons were needed for divalent cation activation of myosin. With changes in pH there were concomitant changes in the apparent affinity of enzyme for substrate (S 0.5), such that with a decrease in pH there was an elevation in K+- or NH4+ -activated myosin's apparent affinity for adenosine triphosphate (ATP), and at the same time a decrease in Vmax values of myosin.

a7f98d41-4470-46a5-85d0-7f7ab588d001

2

The converse was true with the divalent cations, Ca++ and Mn++; here with a decrease in pH there was a concomitant decrease in apparent affinity of myosin for ATP, and at the same time an increase in the enzymatic Vmax values. It appeared that hydrogen ions affected the apparent affinity of myosin for substrate and this in turn affected the rate-limiting step in ATPase reaction.

a7f98d41-4470-46a5-85d0-7f7ab588d001

3

Addition of monovalent cations to the divalent cation activating system lowered the activity of myosin, and the converse was true: divalent cations lowered the activity of myosin when activated by monovalent ones in a monovalent cation activating system.

5d6c0d06-393f-4d34-a0dd-ef501e04339b

0

Distribution of prostaglandin E 9-ketoreductase and NAD+-dependent and NADP+-dependent 15-hydroxyprostaglandin dehydrogenase in the renal cortex and medulla of various species. Regional distributions of PGE 9-ketoreductase and 15-hydroxy-prostaglandin dehydrogenase were examined in the cytoplasmic fractions from the kidneys of seven species. All species contained an NADPH-dependent reductase, as well as NAD+- and NADP+-dependent dehydrogenases in both cortex and medulla.

5d6c0d06-393f-4d34-a0dd-ef501e04339b

1

A previously unrecognized cytoplasmic NADH-dependent PGE 9-ketoreductase was also detected in the cortex and medulla of rat and bovine kidney. Total NAD+- and NADP+-dependent dehydrogenase activity was about equally distributed between the two renal regions of monkey, dog, rat, and swine. Bovine, rabbit, and cat had greater cortical than medullary dehydrogenase activity with ratios of 3, 5, and 10 respectively.

5d6c0d06-393f-4d34-a0dd-ef501e04339b

2

The activities of NAD+- and NADP+-dependent dehydrogenase varied among the renal tissues.

eedbd944-c965-4ea9-9977-8404caa7fdd9

0

Normal blood-gas values in lambs during neonatal development and in adult sheep. Arterial oxygen (PaO2) and carbon dioxide (PaCO2) tensions and pH were determined in 20 lambs during development from two weeks to five months of age and in 34 adult sheep. Throughout the period the lambs' mean PaCO2 (33.1

eedbd944-c965-4ea9-9977-8404caa7fdd9

1

mm Hg) and pH (7.46) values were similar to those determined in the adult sheep (PaCO232.1 mm Hg; pH 7.48). The lamb's mean PaO2 increased from 63.3 mm Hg at two weeks of age to about 80 mm Hg at eight weeks and by 20 weeks was similar to the mean PaO2 (88.0

eedbd944-c965-4ea9-9977-8404caa7fdd9

2

mm Hg) of adult sheep.

b9537704-6d31-4c41-ba75-4b20f2d0672b

0

[The clinical importance of angiography in the diagnosis of periarteritis nodosa]. Report on a 53 years old patient with renal failure. Angiography showed multiple micro-aneurysms in kidneys and liver, in some instances also in the pancreatic, duodenal and mesenterial arteries. Muscle biopsy confirmed the suspicion of arteriitis nodosa. Clinically the diagnosis of necrotizing arteriitis is difficult. Angiography settles the diagnosis, but only positive findings of micro-aneurysms prove it. The differential diagnosis is discussed and illustrated.

bbbbd0a9-136e-49c8-8906-59ab032d039f

0

pH and the cytotoxicity of fluoride in an animal cell culture system. To investigate the mechanism for the toxicity of silicate cement as observed in a cell culture system, the effects of pH and fluoride were tested on human epithelial cells (NCTC 2544). At pH 7.3, fluoride concentrations from 15 to 25 mug/ml (0.79

bbbbd0a9-136e-49c8-8906-59ab032d039f

1

to 1.3 mM) had a growth inhibitory effect. When pH of the incubation medium was lowered in the range 7.0 to 6.4, an enhanced cytoxic effect of fluoride was found, and even at 5 to 10 mug/ml growth inhibition occurred. Concomitant with the enhanced cytotoxicity of fluoride at low pH, there was an increased utilization of glucose and formation of lactate.

bbbbd0a9-136e-49c8-8906-59ab032d039f

2

Upon lowering the pH of the incubation medium from 7.4 to 6.7 a twofold increase in the intracellular concentration of fluoride was found.

56ca42f7-c2ed-4cc7-be5d-91fac7aab5a9

0

Dysplasia of the testis and epididymis. Various congenital malformations of the testis and the seminal pathways are illustrated by 10 cases. Though these malformations are often free from symptoms, an increasing number of them are now being discovered in connection with investigations of male infertility. In cases of azoospermia where testicular biopsies show complete spermatogenesis, surgical exploration is indicated. Some of these malformations may then be treated by surgery, with fairly good prospects of restored fertility.

5633524c-06c3-495b-8a83-d61f09f9d759

0

[Lipoprotein X in hepatobiliary diseases]. The diagnostic and prognostic reliability of lipoprotein-X (Lp-X) in demonstrating or ruling out cholestasis has been evaluated in a group of 80 patients with diseases of the liver and/or the biliary tracts, and in 103 subjects with various other diseases.

5633524c-06c3-495b-8a83-d61f09f9d759

1

The results of Lp-X detection were compared with the so-called "enzymes indicating cholestasis": alkaline phosphatase, leucine arylamidase, and gamma-glutamyltranspeptidase. Where possible a histologic specimen of the liver was obtained. The correlation between Lp-X and "enzymes indicating cholestasis" was satisfactory in more than 90% of cases.

5633524c-06c3-495b-8a83-d61f09f9d759

2

When compared with the histologic findings, Lp-X proved to be more reliable than the enzymes. Despite this fact, Lp-X did not show absolute specifity in the detection of cholestasis as there were several negative results in cases with histologically proven cholestasis. Furthermore, the differentiation of intra- and extrahepatic cholestasis was not possible on the basis of Lp-X.

5633524c-06c3-495b-8a83-d61f09f9d759

3

In the control group of 103 patients with other than hepatobiliary diseases, a positive Lp-X result was found in 3 cases. Further investigations in these three patients revealed that primarily unsuspected hepatobiliary disease could not be ruled out. In the follow-up of a hepatobiliary disease the transition of Lp-X to negative indicates a trend towards improvement of cholestasis 1-2 weeks earlier than the enzymes mentioned above.

19337b7e-ed1c-427c-a237-81ae7f98f12c

0

[Proceedings: Home treatment of chronic respiratory insufficiency: inhalation of beta stimulators]. In the author's experience, the longterm treatment of chronic obstructive lung disease should be supplemented by continuous selective stimulation of the adrenergic beta-receptors in the smooth bronchial muscles. The following procedure is recommended: inhalation of 15 min 3 times daily using an adequate aerosol with a powered nebulizer (Pari-Privat), with 2-3 ml Tyloxapol carrier solution or saline with 5 drops salbutamol.

85b038f3-8407-4c17-b719-1dcebb521871

0

[Proceedings: Long-term therapy with antibiotics in chronic bronchitis]. Longterm therapy of chronic bacterial bronchitis assumes two forms: (a) therapy of acute exacerbations, and (b) continuous longterm prophylaxis, chiefly during the 4-7 winter months. Longterm prophylaxis should be confined exclusively to patients with two or more severe annual exacerbations. The commonest pathogens, Haemophilus influenzae and pneumococci, are usually sensitive to ampicillin and amoxycillin, cotrimoxazole (Bactrim or Eusaprim) and tetracyclines.

83572523-6b5c-4afc-bcf4-32cc80f618e0

0

[Isolation, identification and quantitative determination of lysolecithin in the human gastric juice]. Lysolecithin was isolated and identified from the gastric contents of 5 patients with gastric ulcer and erosive and atrophic gastritis. The methods used involved methanolic extration, column chromatography on silica gel and sephadex gel filtration, followed by preparative thin layer chromatography.

83572523-6b5c-4afc-bcf4-32cc80f618e0

1

Identification of lysolecithin was verified in one sample by thin layer chromatography and elementary analysis. A method for quantitation of lysolecithin in human gastric fluid for routine clinical analysis is described, based on the procedure used for identification of this phospholipid. Further, a hemolysis test is proposed for screening gastric contents for lysolecithin concentrations above approximately 10 mg/100 ml.

83572523-6b5c-4afc-bcf4-32cc80f618e0

2

With the quantitative method, an average concentration of 66.1 mg of lysolecithin in 100 ml gastric content was found in the group of 5 patients. The screening test was positive in all 5 samples, but was negative with native gastric juice in 25 persons serving as controls. When the gastric fluid of the controls was concentrated, however, 9 samples gave a positive hemolytic reaction.

83572523-6b5c-4afc-bcf4-32cc80f618e0

3

From these 9 specimens, the lysolecithin concentration was found to average 0.9 mg/100 ml. These findings afford evidence that lysolecithin may be involved as a factor in the pathogenesis of gastric ulceration.

32001cd8-c208-423f-a057-ec904b07a84a

0

[Prinzmetal angina: clinical aspects and coronarographic findings]. The clinical course and coronary arteriographic findings in 5 patients with Prinzmetal's variant angina pectoris are reviewed. In 4 patients who had ST-elevations inferiorly, 1 had minimal, 1 only slight, and 1 medium coronary artery disease; 1 had coronary spasm.

32001cd8-c208-423f-a057-ec904b07a84a

1

1 patient with ST-elevation anteriorly had severe stenosis of the anterior descending coronary artery. All 5 patients had normal left ventriculograms, 3 also had normal left enddiastolic pressure, and 2 slight elevation. Medical treatment was carried out in 2 patients and surgical revascularization in 2. Both treatments were accompanied by marked symptomatic improvement.

32001cd8-c208-423f-a057-ec904b07a84a

2

Spontaneous loss of angina occurred in 1 patient. Prinzmetal's variant angina pectoris may be accompanied by a variety of coronary arteriographic findings and the prognosis appears to be more favorable than previously reported.

02504654-edda-4026-abc1-19fe3f5c9b14

0

[Forms of so-called crytorchism. Studies on 579 patients]. In a material of 579 patients the incidence of the different forms of cryptorchism is investigated. The findings reveal retractile testes in 16.4%, ectopic testes in 23.1%, inguinal retentions in 49.5%, abdominal retentions in 2.3% secondary cryptorchism in 3.5%, and monorchism and anorchism in 4.9%. These results are compared with those of other authors.

f55bd814-6c51-4509-849e-cb86cc6301c1

0

[Sugar-free, tooth-protecting chewing gum and candy. Results of a 7-year study]. Experiences of 7 years with sugarless chewing gums and lozenges (tab. I and II) regarding their tooth protective properties are reported. Telemetry of interproximal plaque pH allows to assess acid formation from carbohydrates by plaque bacteria under almost natural conditions.

f55bd814-6c51-4509-849e-cb86cc6301c1

1

Altogether, 5 chewing gums and 8 lozenges containing sorbitol or mixtures of sorbitol and hydrogenated oligosaccharides were investigated. Lowest pH values during and after chewing sugarless gums varied between pH 6.0 and 7.3. When sucking sugarless lozenges the recorded pH values were between 5.8 and 7.0. In contrast to lozenges, the consumption of sugarless chewing gums becomes particularly important due to their greater stimulation of saliva and buffering capacity of oral fluid.

f55bd814-6c51-4509-849e-cb86cc6301c1

2

All products tested did not acidify interproximal plaque below the critical pH and therefore comply with the regulations of the Swiss Federal Health Authorities with respect to the labeling or marketed sweets with "safe for teeth". New non-fermentable sugar-replacing substrates are being developed. Their utilization in foodstuffs and sweets is being discussed.

b5d1476d-3f01-43ed-a42d-c6320803e262

0

[Churg-Strauss syndrome. Its nosological place. Apropos of a new case diagnosed before death]. Allergic granulomatous angeitis or Churg and Strauss disease, seems to form part of the disease of necrotising angeitis. Clinically, it may be considered when periarteritis nodosa is associated with asthma and marked eosinophilia.

b5d1476d-3f01-43ed-a42d-c6320803e262

1

The diagnosis depends on the pathological findings including the venous and pulmonary lesions, giant cells and the presence of extra-vascular granulomas. The recognition of this disease does not, however, permit one to give a precise prognosis. In the absence of progress concerning the pathogenesis, treatment will be the same as that given in other forms of necrotising angeitis.

19c0bd51-9df2-4b96-be01-d99074e06e42

0

[Periarteritis nodosa and cancer. Apropos of 2 cases]. The authors report two cases of periarteritis nodosa associated with carcinoma. The first case was a man with an anaplastic bronchial carcinoma, the second was a woman with a rectal adenocarcinoma. Study of the association of certain collagen diseases with carcinoma was made to emphasize the great rareness of this association.

794eb874-a87c-4f2a-9677-dbdc76b4c621

0

Nonsurgical control of massive acute gastric mucosal hemorrhage with antacid neutralization of gastric content. A simple and safe method of medical treatment for control of massive acute gastric mucosal hemorrhage is described. The procedure was developed from the observation that gastric HCl played a central role in peretuating the syndrome.

794eb874-a87c-4f2a-9677-dbdc76b4c621

1

The treatment consists in neutralization of the gastric acid with antacid to pH of 7.0. In preliminary observations of consecutive admissions, 19 of 20 (95 per cent) patients treated with this techinique stopped bleeding. The one remaining patient required surgery. There were no deaths. In contrast, 10 of 15 (66 per cent) patients stopped bleeding with conventional medical therapy.

794eb874-a87c-4f2a-9677-dbdc76b4c621

2

Four of the remaining patients required surgery to control the bleeding. One patient did not stop on medical management. All five (33 per cent) patients died.

be3982ae-9fa4-4aae-af1c-f23aab992073

0

Effect of total gastrectomy on acid proteolytic zymogens in serum and urine. Proteolytic pH-activity curve and agar gel electrophoretic pattern of acid proteolytic zymogens in serum and urine were studied in totally gastrectomized patients. In serum, total gastrectomy was found to reduce proteolytic activity markedly, but no appreciable changes could be detected by electrophoretic analysis.

be3982ae-9fa4-4aae-af1c-f23aab992073

1

In urine, however, in addition to the marked reduction of proteolytic activity, changes were found in electrophoretic pattern after total gastrectomy. Namely, fraction Pg 3 tended to persist, while Pg 5 disappeared along with the lapse of time after total gastrectomy. An unusual appearance of fraction Pg 7 in urine was also observed on the occasion of postoperative transient albuminuria.

be3982ae-9fa4-4aae-af1c-f23aab992073

2

Their orgins and related clinical problems were discussed.

6b66b4e1-6e96-4555-8108-771d1c7ab8c2

0

[Pollen diet as an adjuvans of radiotherapy in gynecologic carcinomas]. The introduction of a pollen diet as an adjuvant in the reduction of side effects during radiotherapy of patients with gynaecological cancer is described and its efficacy evaluated. 15 women with carcinoma of the cervix received a pollen diet during irradiation, whilst ten further patients receiving irradiation served as controls without pollen added to the diet.

6b66b4e1-6e96-4555-8108-771d1c7ab8c2

1

Serum enzymes, proteins, vitamins and blood count were analysed before and after irradiation. It appears, that pollen favourably influences the efficacy of irradiation and reduces the frequency of side effects, both subjectively and objectively.

5c12d6df-6ed2-4ea5-9410-d795cef3cb48

0

[Effects of lethal overexposure on gastric secretion in the pig]. The characteristics of gastric secretion following acute gamma exposure (1500 rd) were studied in pigs with a small Pavlov stomach. Spontaneous secretion was practically inhibited when the animals were taken out of the irradiation cell. It slowly recovered in the following hours and its pH, first neutral, turned acid again.

5c12d6df-6ed2-4ea5-9410-d795cef3cb48

1

However, till the third day, it did not recover normal characteristics. The excretion of sodium ions was much increased. Under histaminic stimulation, the responses of irradiated pigs and controls were much similar. The secretory capacities of the gastric mucosa were retained but without spontaneous manifestations. As a conclusion, the early troubles following overexposure must be the consequences of regulation disorders rather than of the direct action of radiation on the stomach.