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784587d8-0278-4c66-998d-18287a5295cf
| 1 |
A linear dose-response relationship was obtained for theophylline. 3. Addition of theophylline (0-2 and 1-6 mg/ml.) during maximal response to histamine increased the secretion further, whereas addition of histamine during maximal response to theophylline did not cause further secretion. 4. The secretory activities of Nalpha-MeH (0-3-5-0 muM), Nalpha-Me2H (1-2-9-5 muM) and 5-MeH (1-5-12 muM) were compared with histamine (0-9-13 muM) on a threshold background secretion induced by theophylline (0-2 mg/ml.
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784587d8-0278-4c66-998d-18287a5295cf
| 2 |
). Linear log.-dose response relationships were obtained for each test drug. The results confirm that Nalpha-MeH is a more potent secretagogue than histamine. 5. Pentagastrin (0-3-1-0 mug/ml.) stimulated HCl secretion in approximately half the experiments. The response was often transitory.
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784587d8-0278-4c66-998d-18287a5295cf
| 3 |
In the other experiments, pentagastrin had no effect on HCl secretion although subsequent administration of histamine did stimulate HCl secretion.
|
12b760b4-7a5f-491c-9436-36967ab92924
| 0 |
Two components of the calcium current in the egg cell membrane of the tunicate. The Ca current of the egg cell membrane of a certain tunicate, Halocynthia roretzi Drasche, was studied by the voltage-clamp technique. 2. The Ca current in the standard artificial sea water (ASW) was produced at the critical membrane potential of -10 mV after inactivating the Na current by conditioning depolarization, -30 to -15 mV.
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12b760b4-7a5f-491c-9436-36967ab92924
| 1 |
The Ca current was abolished by replacing Ca in ASW with Mg2+ or Mn2+. The Ca current was not significantly influenced by replacing Na in ASW with choline or Cs. 3. The relation of Ca current to the external Ca concentration was a monotonously increasing function, but was not linear.
|
12b760b4-7a5f-491c-9436-36967ab92924
| 2 |
The current tended to saturate above 50 mM-Ca. In 100 mM-Ca ASW, the maximum peak inward current of Ca ranged from 1 to 7 X 10(-9) A. 4. The kinetics of Ca current was accurately analysed because of the small contribution of K outward current and was found to be relatively slow in comparison with the Na current.
|
12b760b4-7a5f-491c-9436-36967ab92924
| 3 |
The peak time and the half-decay time of the maximum Ca current at about 25 mV were about 25 and 100 msec respectively in 100 mM-Ca ASW at 15 degrees C. 5. Addition of 20 mM-Co2+ to 100 mM-Ca ASW reduced Ca current to one fourth and 1 mM-La3+ to 100 mM-Ca ASW abolished the current.
|
12b760b4-7a5f-491c-9436-36967ab92924
| 4 |
6. Sr and Ba could substitute for Ca in Ca channels. The selectivity ratios for the 'Ca channels's were Ca (1-00):Sr(1-17):Ba(0-71) at a potential level of +40 mV. The Ca current in the egg cell membrane appeared to be essentially the same as the Ca current in the common excitable membranes, such as the crustacean muscle fibre.
|
12b760b4-7a5f-491c-9436-36967ab92924
| 5 |
7. The polyvalent cations including Ca ion and monovalent H+ ion showed the stabilizing effect upon both Na and Ca currents, by shifting V-I relations along the voltage axis. From the prediction of a theory of the diffuse double layer, the shift in the V-I relation induced by those cations should be directly related to their binding powers to the membrane.
|
12b760b4-7a5f-491c-9436-36967ab92924
| 6 |
Thus, the sequence of the binding powers was inferred as H+ greater than La3+ greater than Co2+ greater than Mn2+ greater than Ca2+ greater than Sr2+ larger than or equal to Ba2+ greater than Mg2+. 9. In Na-free ASW, such as isotonic Ca ASW, Ca current was composed of two components.
|
12b760b4-7a5f-491c-9436-36967ab92924
| 7 |
The one component was the Ca current described in 1 to 6. The other was also dependent upon the external Ca concentration, but showed the more negative critical membrane potential and the faster kinetics. It was concluded that this component should be the Ca current through Na channels.
|
12b760b4-7a5f-491c-9436-36967ab92924
| 8 |
10. The selectivity among Ca, Sr and Ba for 'Ca' current through 'Na channels' was significantly different from that of 'Ca' current through 'Ca channels', being Ca greater than Sr larger than or equal to Ba = 0.
|
36a4d500-c338-44f2-9aa8-000422131a33
| 0 |
Oestrogenic sensitivity of rat uterine secretion. Ovariectomized adult rats with closed uteri were treated for 7 days with different oral and s..c. doses of oestradiol, oestrone, oestriol and ethinyl oestradiol. All treatments elicited the production of uterine fluid and the potencies of oestrogens were related to the amount of fluid secreted.
|
36a4d500-c338-44f2-9aa8-000422131a33
| 1 |
Ethinyl oestradiol and oestradiol displayed similar activity when given s.c. A daily dose of 0-003 mg oestradiol/kg resulted in about 700 mg fluid. Oestrone was 3-10 times and oestriol about 100 times less active. Orally, ethinyl oestradiol was the most potent substance and 700 mg secretion was obtained with a dose of 0-03 mg/kg daily.
|
36a4d500-c338-44f2-9aa8-000422131a33
| 2 |
Oestradiol was about 30 times, oestrone about 100 times and oestriol 50 times less active than ethinyl oestradiol by this route. The viscosity of the secretion was unaffected, remaining between 1-6 and 2-4 cP. The pH of the fluid did not change, but that of the uterine lumen diminished slightly.
|
36a4d500-c338-44f2-9aa8-000422131a33
| 3 |
These effects of oestrogens were associated with an increase in the weight of the empty uterus and a decrease in body weight.
|
ec60cba5-69b1-4336-acc8-dbecc88f21e7
| 0 |
A new series of cardioselective adrenergic beta-receptor blocking compounds. 1-(2-Acyl-4-acylaminophenoxy)-3-isopropylaminopropan-2-ols. A series of 1-(2-acyl-4-acylaminophenoxy)-3-isopropylaminopropan-2-ols has been synthesized and examined for beta-receptor blocking and antiarrhythmic activity. Several of these compounds are more than 20 times as active in blocking cardiac beta-receptors than vascular beta-receptors when given intravenously to anesthetized cats.
|
ec60cba5-69b1-4336-acc8-dbecc88f21e7
| 1 |
The activities have been correlated quantitatively with partition and steric substitution constants. The observed relationships are consistent with a tentative proposal that the vascular receptor is situated in a more lipophilic environment than the cardiac receptor so that there is a differential transport effect between the two types of receptor.
|
4a669a6a-7b01-4ff2-8ac4-365b0319609a
| 0 |
Teaching interviewing for pediatrics. This paper describes a structured course for teaching interviewing which focuses on the interaction between the patient and the practitioner. Three main areas of learning were selected because of their universal application: relationship, communication, and feelings. Theoretical material is related to positive and negative interactions with patients, and these are described behaviorally in a checklist form.
|
4a669a6a-7b01-4ff2-8ac4-365b0319609a
| 1 |
The development of good interviewing techniques consists of increasing the positive interactions and learning to use them as diagnostic and therapeutic tools. Different methods are utilized to help students apply these skills in clinical situations. Although this course was developed for a specific group of pediatric practitioners, it can be utilized by all types of health care professionals.
|
53206088-a5fd-41b0-ad08-cc37e5045ad1
| 0 |
Effect of calcium on the membrane potential of Amphiuma red cells. An increase in extracellular Ca concentration causes the membrane of giant red cells of the salamander, Amphiuma means, to undergo a marked, transient hyperpolarization. This hyperpolarization is caused by an increase in K permeability of the membrane as judged from the K sensitivity of the membrane potential and from the rate of K loss under influence of raised extracellular Ca concentration.
|
53206088-a5fd-41b0-ad08-cc37e5045ad1
| 1 |
At constant external pH, the induction of hyperpolarization by increased extracellular Ca has a relatively well-defined threshold concentration. Furthermore the phenomenon is of an "all or none" type with most of the cells having membrane potential values either in the normal range (about -15 mV) or in the range -40 to -70mV.
|
53206088-a5fd-41b0-ad08-cc37e5045ad1
| 2 |
Shortly after suspension in Ringer's with 15 mm Ca, most if not all of the individual cells are hyperpolarized. Upon continued exposure (5-20 min) to the higher Ca concentration the membrane potential returns to the normal value in a fashion compatible with an "all or none" response.
|
53206088-a5fd-41b0-ad08-cc37e5045ad1
| 3 |
The observed Ca effect is sensitive to the pH of the suspending medium. At pH 6.2 the response is absent whereas the hyperpolarization is markedly stronger at pH 8.2 than at PH 7.2. It is argued that a reliable transport number for K under influence of Ca cannot be estimated from the slope of membrane potential vs.
|
53206088-a5fd-41b0-ad08-cc37e5045ad1
| 4 |
log (extracellular K concentration). This is probably related to the fact that the membrane potentials of the cells in the population do not stay constant in time. The above phenomenon is compared with the Ca-induced K permeability in poisoned human red cells or red cell ghosts. It is important to note that the cells employed in the present study are neither poisoned nor mechanically disrupted.
|
53206088-a5fd-41b0-ad08-cc37e5045ad1
| 5 |
This study emphasizes that the role of Ca in regulating cell membrane permeability to K seems to be a general feature.
|
78b0faba-ed37-4472-a25b-1764bad56d1b
| 0 |
Transitory postnatal hemolysis of calf red cells by amino acids. Among the amino acids which can be solubilized to give a concentration of 300 mm at near physiological pH, histidine and proline caused a complete hemolysis of newborn calf but not of adult cow red cells within 20 to 30 minutes at 38 degrees C.
|
78b0faba-ed37-4472-a25b-1764bad56d1b
| 1 |
While hydroxyproline, valine, and serine resulted in a partial lysis of calf cells, threonine, glutamine, and glycine were ineffective. In this communication, emphasis has been focused on the mode of the lytic process by histidine which was found to be affected by several governing parameters including the pH, temperature and the extracellular salts in the solution.
|
78b0faba-ed37-4472-a25b-1764bad56d1b
| 2 |
Unlike human red cells suspended in isotonic histidine, both calf and cow cells lost little Na and K ions. In the presence of 300 mm histidine, both calf and cow cells displayed an instantaneous uptake of histidine amounting to 20 to 45 mumoles/ml RBC followed by a slow influx rate of 0.25
|
78b0faba-ed37-4472-a25b-1764bad56d1b
| 3 |
to 0.5 mumoles/ml RBC X min. The extent to which histidine entry was allowed by the cell was counterbalanced by Cl- efflux, resulting in little change in cell volume prior to hemolysis. Moreover, histidine-induced hemolysis can be prevented by 1 mm or lower PCMBS without a discernible effect on histidine influx suggesting a possible membrane lesion or damage at the outer surface of the cell.
|
78b0faba-ed37-4472-a25b-1764bad56d1b
| 4 |
Hemolysis induced by histidine decreased substantially when a calf reached two months of age at which time the red cells containing the fetal hemoglobin are virtually depleted. The results of hemoglobin electrophoresis obtained during this postnatal period revealed that those cells resistant to histidine hemolysis almost invariably contain the adult type hemoglobin suggesting a selective, specific action of the amino acids on the fetal cells.
|
de479a1b-8716-4ce9-ab77-4072b8b41588
| 0 |
ATP synthesis driven by a protonmotive force in Streptococcus lactis. An electrochemical potential difference for hydrogen ions ( a protonmotive force) was artifically imposed across the membrane of the anaerobic bacterium Streptococcus lactis. When cells were exposed to the ionophore, valinomycin, the electrical gradient was established by a potassium diffusion potential.
|
de479a1b-8716-4ce9-ab77-4072b8b41588
| 1 |
A chemical gradient of protons was established by manipulating the transmembrane pH gradient. When the protonmotive force attained a value of 215 mV or greater, net ATP synthesis was catalyzed by the membrane-bound Ca++, Mg++ -stimulated ATPase. This was true whether the protonmotive force was dominated by the membrane potential (negative inside) or the pH gradient (alkaline inside).
|
de479a1b-8716-4ce9-ab77-4072b8b41588
| 2 |
Under these conditions, ATP synthesis could be blocked by the ATPase inhibitor, dicyclohexylcarbodiimide, or by ionophores which rendered the membrane specifically permeable to protons. These observations provide strong evidence in support of the chemiosmotic hypothesis, which states that the membrane-bound ATPase couples the inward movement of protons to the synthesis of ATP.
|
07c9354c-3b7c-4d44-ae16-88cf5b658769
| 0 |
Effect of local anesthetics on chloride transport in erythrocytes. The self-exchange of chloride isotopes across the human erythrocyte membrane was inhibited by tetracaine, benzocaine, and lidocaine. The inhibition by tetracaine was increased at higher pH values, but was not exclusively due to the uncharged form of tetracaine.
|
07c9354c-3b7c-4d44-ae16-88cf5b658769
| 1 |
The inhibition was effective within 5 seconds, was reversible, was non competitive with chloride ions, and was not reversed by calcium ions. These findings indicate that local anesthetics react with the erythrocyte chloride carrier at a site separate from the chloride site and cause inhibition of anion transport by a specific mechanism not involving changes in the surface charge density on the erythrocyte membrane.
|
bf2c9482-c0c8-427f-bff7-45ba5d865878
| 0 |
Biochemical properties of cyclic nucleotide phosphodiesterase in metastasizing and nonmetastasizing rat mammary carcinomas. The biochemical properties of cyclic nucleotide phosphodiesterases in a nonmetastasizing and a spontaneously metastasizing rat mammary carcinoma were compared. The phosphooiesterases in both tumors had a pH optimum of around 8.0 and preferentially hydrolysed cyclic purine nucleotides.
|
bf2c9482-c0c8-427f-bff7-45ba5d865878
| 1 |
The rate of hydrolysis of purine nucleotides in the nonmetastasizing tumor was two times higher than in the metastasizing tumor, but the rate of pyrimidine nucleotide hydrolysis was equal in both tumors. Theophylline, caffeine, and D,L-4-(3-butoxy-4-methoxybenzyl)-2-imidazolidinone (Ro20-1724) inhibited the enzyme activity in both tumors;
|
bf2c9482-c0c8-427f-bff7-45ba5d865878
| 2 |
the percent inhibition was the same by each inhibitor. The cyclic nucleotie phosphodiesterase activity in either tumor was stimulated by Mg++, Mn++, and Co++ and suppressed by Ca++, Zn,++, and Ni++. EDTA inhibited the activity below the basal level (activity in the absence of added cation), an this inhibition could be recovered up to the basal level by an equimolar quantity of either Mn++ or Mg++.
|
bf2c9482-c0c8-427f-bff7-45ba5d865878
| 3 |
Further stimulation of the enzyme activity with increasing concentrations of divalent cations was observed only with Mn++. Similar effects were observe with ethylene glycol bis(beta-aminoethyl ether)-tn,n-tetraacetic acid. The stimulatory cations affected both the low and high Michaelis constant (tkm) enzymes in these tumors by increasing the maximum velocity.
|
bf2c9482-c0c8-427f-bff7-45ba5d865878
| 4 |
In the low Km enzyme, the Km was also slightly increased. Neither guanosine 3',5'-cyclic monophosphate nor adenosine 3',5'-cyclic monophosphate had any effect on the hydrolysis of the other at physiologic levels.
|
ae053885-5476-46c1-8234-3a7c7a5d1d1a
| 0 |
Hybrid-versus-parental strain reaction. III. Comparative mortality in parental strain mice of the H-2k genotype. Lethally irradiated parental strain male and female mice were inoculated with marrow from reciprocal hybrid donors of the same sex. Hybrid cells homozygous for the H-2k genotype could recognize the quantitatively greater antigenicity of the parental strain CBA male recipients only.
|
ae053885-5476-46c1-8234-3a7c7a5d1d1a
| 1 |
The more severe reaction occurred when the maternal strain of the hybrid donor was allogeneic to the recipient, which indicates the maternal effect on the antigen recognition system. This demonstration of a maternal influence on the expression of paternally derived tissue antigens made it possible to attribute the secondary disease syndrome to a hybrid-versus-parental strain reaction.
|
ae053885-5476-46c1-8234-3a7c7a5d1d1a
| 2 |
The apparent differences in mortality between male and female recipients could not be attributable to X or Y chromosome disparity without additional transfers of appropriate marrow from males to females and females to males. In all cases, the parental strain-versus-hybrid reaction resulted in greater mortality than that observed in the hybrid-versus-parental strain reaction.
|
0cab307a-6a1c-4272-a737-b9790c8a9102
| 0 |
Cryptorchidism, hernia, and cancer of the testis. Risk of cancer of the testis was related to nondescent and hernia in a comparison of 596 testicular cancer patients and 602 unaffected men who had been in active service in the U.S. Army between 1950 and 1970. Medical histories were obtained from routine service records.
|
0cab307a-6a1c-4272-a737-b9790c8a9102
| 1 |
Undescended testis was associated with a testicular cancer risk 8.8 times that of normal. Among cancer patients with a history of undescended testis, seminomas were nearly twice as frequent as in the remaining patients. Of 14 patients with unilateral undescended testis, 12 had the tumor on the side of the defect.
|
0cab307a-6a1c-4272-a737-b9790c8a9102
| 2 |
Testicular cancer risk was estimated to be 2.9 times higher in men who had reported having had an inguinal hernia than in those who had not. Side of hernia and side of tumor were not associated; histologic type was not related to history of hernia.
|
83971748-3738-42f6-a82f-88660db91c38
| 0 |
Hemodynamic and respiratory responses of conscious swine to E. coli endotoxin. The injection of a sublethal bolus of E. coli into conscious swine produces an early increase in PAP and a decrease in LAP. This hemodynamic effect may be secondary to the pulmonary venous constriction seen in other species, or may relate to demonstrated multiple pulmonary microemboli.
|
83971748-3738-42f6-a82f-88660db91c38
| 1 |
Hypoxemia developed in only four of 17 animals although all endotoxin-treated swine showed interstitial edema and elevated wet/dry weight ratios with normal pulmonary surfactant. In addition, endotoxin-treated swine developed signs of disseminated intravascular coagulation, with renal cortical infarcts in 44%, and coronary arterial thrombi in 28% including one transmural myocardial infarction.
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83971748-3738-42f6-a82f-88660db91c38
| 2 |
This effect was observed in the absence of prolonged hypotension in swine and should provide a useful model for further study of the relationship of endotoxin to disseminated intravascular coagulation.
|
e0971041-1c96-4af1-a5e4-29695e320d2c
| 0 |
Isoaccepting species of serine tRNA coded by bacteriophage T5sto. By aminoacyl-tRNA-DNA hybridization and chromatographic analysis, evidence was provided that the bacteriophage T5stO codes for two tRNAser species. Trinucleotide- or polynucleotide-stimulated binding experiments assigned the codons UCC or UCU to these two tRNAser species. They also suggested that the synthesis of these two tRNAser species does not modify the reading capacity for codons less used in Escherichia coli F and corresponds to a different situation compared with the T4-coded tRNA's.
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ce75493c-0846-4563-b876-b57365ae0da0
| 0 |
Purification and characterization of mouse interferon with novel affinity sorbents. Several novel selective sorbents for mouse interferon are described that exploit the hydrophobic property and glycoprotein nature of this molecule. Low-molecular-weight ligands (hydrocarbons) and high-molecular-weight ligands (bovine serum albumin) immobilized on agarose bind selectively mouse L-cell interferon.
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ce75493c-0846-4563-b876-b57365ae0da0
| 1 |
The high selectivity of binding is due primarily to a hydrophobic effect, although electrostatic forces are also apparently involved. Mouse L-cell interferon binds to immobilized serum albumin and can be completely recovered by raising the ionic strength of the eluant. The specific activity of interferon preparations can be increased 2,000-fold to a value of 3 x 10(8) reference units per mg of protein in a single step with full recovery of the antiviral activity.
|
ce75493c-0846-4563-b876-b57365ae0da0
| 2 |
A selective adsorption, although to a lesser degree, can be also obtained on hydrocarbon-coated agarose (Affi-Gel 202), resulting in 300-fold purification on desorption. The existence of two major components of mouse interferon was revealed upon its chromatography on the following sorbents: (i) bovine serum albumin-agarose, (ii) omega-carboxypentyl-agarose;
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ce75493c-0846-4563-b876-b57365ae0da0
| 3 |
and (iii) Bandeiraea simplicifolia lectin-agarose. This report thus provides for the first time a means for efficient and clear-cut separation of interferon components, thus enabling their further characterization.
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111a689b-c168-4b78-bbf6-b064b4107467
| 0 |
Induction of prophage SPO2 in Bacillus subtilis: isolation of excised prophage DNA as a covently closed circle. Bacillus subtilis tryC2, thyA, thyB, lysogenic for the phage DNA polymerase negative mutant SPO2 susL244, was induced under conditions preventing phage and bacterial DNA synthesis. The biological activity of DNA from induced cells and from uninduced controls was assayed by transformation and transfection, respectively.
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111a689b-c168-4b78-bbf6-b064b4107467
| 1 |
About 50% of the phage DNA biological activity in DNA extracted from induced cells was resistant to exposure to pH 11.8 TO 11.9. This DNA was operationally defined as alkali-resistant phage DNA. Transforming bacterial DNA from uninduced or induced cells and transfecting DNA from uninduced cells were more than 95% inactivated after exposure to high pH.
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111a689b-c168-4b78-bbf6-b064b4107467
| 2 |
The alkali-resistant phage DNA was characterized by sucrose gradient centrifugation, by centrifugation in cesium chloride-propidium iodide, and by electron microscopy. It was found to consist of a majority of covalently closed circular DNA molecules. Length measurements of a few relaxed circular molecules indicate a molecular weight of these similar to that previously found for mature SPO2DNA.
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111a689b-c168-4b78-bbf6-b064b4107467
| 3 |
Attempts to isolate similar covalently closed circular phage DNA from induced bacteria lysogenic for SPO2 phage with a functional DNA polymerase gene were unsuccessful. The gene order in mature and prophage SPO2 was determined by rescue of single and double markers from the respective type of DNA. The data obtained show that prophage DNA is (genetically) permuted relative to mature DNA.
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111a689b-c168-4b78-bbf6-b064b4107467
| 4 |
The phage attachment site is suggested to be located between genes I and J.
|
c8411ec2-d211-4065-836c-58c7bd5af606
| 0 |
Escherichia coli capsule bacteriophages. VIII. Fragments of bacteriophage 28-1. As described previously, a host capsule depolymerase activity is associated with the particles of Escherichia coli capsule bacteriophage 28-1. This is a large virus with a long, contractile tail terminating in a base plate with spikes.
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c8411ec2-d211-4065-836c-58c7bd5af606
| 1 |
In the present work, isolated virions were exposed to a variety of dissociative reagents and conditions. They were then tested for residual infectivity and depolymerase activity, as well as inspected under an electron microscope. Very mild acid treatment (10 to 15 min at pH 4.0 and 37 C) was found to cause a specific detachment of some phage spikes, together with a moderate drop in both infectivity and depolymerase activity.
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c8411ec2-d211-4065-836c-58c7bd5af606
| 2 |
Large batches of viruses were fragmented in this manner, and the detached spikes were isolated. The host capsule depolymerase activity was found to be associated with these organelles. In negatively stained preparations, the spikes exhibited a length of approximately 18 nm and a thickness of about 5 nm.
|
c8411ec2-d211-4065-836c-58c7bd5af606
| 3 |
By sodium dodecyl sulfate-polyacrylamide gel electrophoresis, they were found to contain polypeptides with molecular weights of 80,000 and 145, 000.
|
8e7e2b79-046b-40f8-b33a-fd91f756597a
| 0 |
Studies on mode of antagonism between adrenergic beta-mimetics and beta-blocking agents (I). Beta-blocking action of mescaline and its derivatives. In order to clarify whether or not trimetoquinol (TMQ) and isoproterenol (ISO) interact with the same receptor, the pA2 values of propranolol (PR) and certain trimethoxybenzene derivatives were measured, using isolated guinea pig tracheal chains.
|
8e7e2b79-046b-40f8-b33a-fd91f756597a
| 1 |
Each of PR, mescaline (MES) and its derivatives gave almost the same pA2 values for TMQ and ISO. Introduction of an alkyl group into the N atom of MES increased the affinity to the receptor in the order of methyl and isopropyl as well as the structureactivity relationship of catecholamines, while that of hydroxyl group in the beta-position of the side chain decreased pA2 values.
|
8e7e2b79-046b-40f8-b33a-fd91f756597a
| 2 |
The slopes of the regression lines for anti-TMQ action of MES derivatives as well as PR were almost one, but those for their anti-ISO action were less than 0.3. 3,4,5-Trimethoxyaniline and 3,4,5-trimethoxybenzoic acid had little activity as beta-blocking agents. These results suggest the possibility that TMQ and ISO would interact with the same receptor sites.
|
8e7e2b79-046b-40f8-b33a-fd91f756597a
| 3 |
The importance of the trimethoxybenzene and the phenethylamine moieties in the MES-derivatives for anti-TMQ action is discussed.
|
abd03081-66e2-4bf8-aed3-8f92bab1ffe6
| 0 |
Regulation of tyrosine hydroxylase activity by prostaglandin E1 in guinea pig adrenal gland. The action of prostaglandin E1 on tyrosine hydroxylase activity in adrenal slices of guinea pig was studied. The activity of tyrosine hydroxylase and was decreased by the incubation of adrenal slices with prostaglandin E1 at concentrations beyond 2 mug per ml for 2 hours.
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abd03081-66e2-4bf8-aed3-8f92bab1ffe6
| 1 |
The activity of tyrosine hydroxylase was stimulated by dibutyryl adenosine 3',5'-monophosphate in slices of guinea pig adrenal glands. Incubation of adrenal slices wtth the combination of PGE1 and DBc-AMP lead to a tyrosine hydroxylase activity higher than that with PGE1 alone, but not as great as DBc-AMP alone.
|
abd03081-66e2-4bf8-aed3-8f92bab1ffe6
| 2 |
It was suggested that PGE1 inhibited the enzyme activity independently of the cyclic AMP level. Other prostaglandins such as PGA1 and PGB1 were deficient to the extent that the tyrosine hydroxylase activity was decreased. PGE1 inhibited the enzyme activity much to the same extent seen with protein synthesis inhibitors such as cycloheximide and actinomycin D.
|
abd03081-66e2-4bf8-aed3-8f92bab1ffe6
| 3 |
However, PGE1 did not influence the incorporation of L-leucine-14C into acid insoluble protein. The studies reported here showed that PGE1 inhibited the synthesis of tyrosine hydroxylase.
|
35e96f17-638c-401a-b3a5-7fcc286335d1
| 0 |
[The role of HCO3- ATPase in H+ /HCO3-Secretion (author's transl)]. Active buffer transport, e.g. H+ -secretion by stomach and kidney and HCO3--secretion by pancreas and salivary glands, is linked with the presence of a HCO3-stimulated ATP-Phosphohydrolase. In contrast to (Na+ -k+)-ATPase which is considered to be equivalent to the Na+ pump, the HCO3--ATPase requires only one ion for activation and is insensitive to ouabain.
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35e96f17-638c-401a-b3a5-7fcc286335d1
| 1 |
The HCO3--ATPase is found in the plasma membrane of the epithelia, but in contrast to the (Na+ -k+)-ATPase it is located in the luminal cell border. The activity of the HCO3--ATPase changes in parallel along with the rate of active buffer transport, a finding which underlines its importance as a transport enzyme.
|
35e96f17-638c-401a-b3a5-7fcc286335d1
| 2 |
Several disorders of buffer transport are described which are possibly associated with a defect of the HCO3--ATPase system.
|
64e289ed-794d-4e8a-a391-80f51b962204
| 0 |
[Interlocking medullary nailing. Indications, technic with a new guiding instrument. Analysis of the 1st 50 operations]. After a review of Küntsher's intramedullary nailing, the author resumed the informations about the interlocking medullary nail and its technique. A new device, as a guide instrument for easier application of the transverse bolts was constructed on the basis of authors concept.
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64e289ed-794d-4e8a-a391-80f51b962204
| 1 |
Using the new technique and guide instrument X-ray television controll is not necessary for placing the bolts in their right places through a small incision. The time of operation and the risk of infection was also diminished by the new technique. The indications for the interlocking medullary nailing have been completed by the author with the pathologic fractures.
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64e289ed-794d-4e8a-a391-80f51b962204
| 2 |
The first 50 cases, treated by the new technique of the interlocking medullary nailing are analysed and a few cases are reported in detail. Good results have been obtained as regards both the bone union and the functional results. Based on the good results the new technique of the interlocking medullary nailing is recommended by the author.
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c4cb2e59-9cf4-4acc-855f-684a193832c4
| 0 |
[Tissue specific inhibition of lymphocyte proliferation by spleen extract (lymphocyte chalone) (author's transl)]. Aqueous spleen extracts were purified using acetone precipitation, membrane filtration, affinity chromatography, and dialysis. These extracts were able to inhibit thymidine incorporation into lymphoid cells (MKT-CH and PHA-stimulated lymphocyte cultures).
|
c4cb2e59-9cf4-4acc-855f-684a193832c4
| 1 |
They did not influence non lymphoid tissue (melanoma cells Mel Ei 78 and Ehrlich ascites cells). The inhibition was reversible and the purified extracts were not cytotoxic. The extracts correspond to a chalone. Their importance for prevention of graft versus host reaction and for treatment of lymphoproliferative diseases is discussed.
|
253a5320-a00e-4c73-a81b-c7d1549ffc11
| 0 |
[Supporting role of the fibula in tibial fractures]. The possibilities of the supporting effect of the fibula and of its preclusion are discussed. The indication of the fibulotomia is dealt with. According to the authors' standpoint in the case of the anatomical reposition of the tibial fracture and after its staple synthesis the supporting effect of the fibula is not be be feared. In these cases the reposition and the osteosynthesis of the fibula neutralize fairly well also the motive forces acting on the tibial fracture.
|
d661cd7e-898d-4f99-bb9f-a8cf307cf061
| 0 |
[Clinical aspects and pathology of traumatic lesions of the optic nerve]. The cause of the unilateral complete blindness (amaurosis traumatica) occurring in the case of closed cranial injury has been sought for in the optic nerve canal (canalis opticus syndrome). For the decompression of the optic nerve surgical approach has been performed in several institutes and by various neurosurgeons.
|
d661cd7e-898d-4f99-bb9f-a8cf307cf061
| 1 |
These interventions lead to no result, irrespective of the time of the operation or the surgical technique. On the basis of the data of the literature and their material the authors came to the conclusion that since the alteration of the optic nerve has been histologically observed not only in the area of the optic nerve, but also in the free intracranial and intraorbital sector, this was the cause of the failure.
|
d661cd7e-898d-4f99-bb9f-a8cf307cf061
| 2 |
The authors' five cases are demonstrated with light and electron microscopic examinations.
|
c8fd2a17-6b98-4da8-b123-5575a2bc2429
| 0 |
[Preservation of crushed extremities]. For the conservation of crushed extremities all achievements of up-to-date traumatology are to be used. The impairement of the seriously crushed extremity displays a certain similarity to the polytraumatism involving the whole organism. This is to be taken into consideration in the surgical treatment. Conserving the vitality of the extremity deferred treatment and reconstructive operations at a later date become possible. As absolute rule must be in view that all cases are to be examined with the greatest care and individually, as regards the surgical treatment.
|
62920dea-2d64-420b-b1ae-f5fbd7733eae
| 0 |
[Experience with the management of subtalar dislocation]. In 10 and 3 years resp., material of two surgical departments - with great material - 10 cases of luxation - without fracture - occurred in the subtaler joint have been treated. All 10 patients suffered covered, subtaler dislocations. After conservative treatment all 10 patients recovered and are back at work.
|
5d2a9d35-4f75-440b-8ff6-48abfe277aa9
| 0 |
[Treatment of contracture of the finger joints by capsulectomy and spring-splints]. The treatment performed in 84 cases of contracted PIP articulations is reported, -in 50 cases the treatment has been carried out with spring-actuated splint and in 34 cases with capsulectomy. It has been found by the authors that the results of the physico-therapeutic treatment used so-far may be still more improved, -satisfactory result has been obtained in more than the half of the author's cases.
|
5d2a9d35-4f75-440b-8ff6-48abfe277aa9
| 1 |
The advantages of the use of the spring-acutatd splint as against Quengel's method are emphasized. Capsulectomy performed in very serious cases resulted in improvement of the articulation motion in 50% of the cases.
|
4a0bdcf8-3cb6-467f-8911-869ba9ca1639
| 0 |
[Experimental single-stage reconstruction of the tendon sheath and flexor tendon (free tendon graft, using a vein for sheath on the flexor tendon in dogs)]. In dog experiments the flexor tendons of the 2nd toe together with their tendon sheaths have been extirpated by the authors. Then on the place of the tendon sheath complex-resembling the human hand's "no man's land" -for the substitution of the tendon sheath-free inautotransplants with long vein-segments have been grafted in one sitting.
|
4a0bdcf8-3cb6-467f-8911-869ba9ca1639
| 1 |
Resuming the results of the macroscopic and light microscopic examinations carried out in definite times it has been found by the authors that while the vein segment was revascularized in the course of one or two weeks, the regeneration of the tendon transplant was slightly retarded. Between the vein and the tendon but adhesion of medium degree were found.
|
4a0bdcf8-3cb6-467f-8911-869ba9ca1639
| 2 |
The possibilities of the clinical use of the method are discussed.
|
f69a6493-4e1b-414f-b266-2fa457254e82
| 0 |
[Reconstruction of the injured flexor tendon in the proximal half of the "no man's land" by a modified method (tendon sheath reconstruction using a vein graft)]. On the basis of long years' experiences the "no man's land" has been divided by the author into 2 parts:
|
f69a6493-4e1b-414f-b266-2fa457254e82
| 1 |
the proximal and the distal part. For the treatment of the flexor tendon lesions occurred in the distal part of the author advocates his method already published: in the "tendon sheath" formed from the vein its "bridging" by free tendon transplant. If the lesion occurred in the proximal part, the formation of a long "tendon sheath" from a vein and then its "bridging" by long tendon transplant are advocated by the author.
|
b0715b16-988d-4a12-8045-f02493bc557b
| 0 |
[Isolated luxation of the trapezium bone]. The luxation of the os trapezium without fracture - a very rare lesion - is reported. This is the first publication in the Hungarian literature of this sort. Proper diagnosis was established after the patient's admission. Covered reduction of the luxation was made, and the luxated bone was fixed by percutaneous wiring and plaster-bandage. The patient recovered without complications.
|
5d797143-a6f3-402b-82ed-cf51713eade9
| 0 |
[Amputation and rehabilitation]. Amputation is maybe the oldest and most frequent surgical intervention. After the review of the concept of rehabilitation, its methods and the improvement of the rehabilitation technique the earling opinions in respect of the height of the amputation, the surgical technique and the post-operative treatment - the use of a prosthesis included - are discussed by the author.
|
3ac67e52-b52b-4b59-87b5-0e5ebc72e37f
| 0 |
[Special care of injured patients after returning to work]. The changes in the type of injury, as well as in the treatment, and the consequences observed during the check-up of the injured patients set the problem of the prolonged care of the patients after the articular fractions of the lower extremity, amputation, arthroplasty, and severe lesions of the hand. Systematic observation, eventual change of the life and work conditions, temporary rest, conservative treatment or surgical intervention performed in due time allow the prevention of serious complications and assure lasting recovery.
|
720ffb02-1705-478f-bef3-54294747b7ef
| 0 |
Chemical injuries of the upper extremity. The prompt recognition and management (Tables 8-1 and 8-2) of chemical burns of the upper extremity may prevent injury to the deep structures of the hand and may make the difference between satisfactory rehabilitation and crippling deformities. Immediate irrigation with water is the single most important treatment that can be carried out, and should be continued for at least an hour and often for several hours, depending on the severity of the injury.
|
720ffb02-1705-478f-bef3-54294747b7ef
| 1 |
Precious time should not be wasted hunting for a specific neutralizing agent. Hydrofluoric acid injuries and phosphorus injuries are the two exceptions to this principle. After copious irrigation and débridement, small superficial burns may be treated without dressings or topical therapy. Large partial-thickness burns are best treated with Sulfamylon burn cream and then with with biologic dressings until healing is achieved.
|
720ffb02-1705-478f-bef3-54294747b7ef
| 2 |
Full-thickness injuries of limited extent should be excised and skin-grafted to regain maximum function, and more extensive burns treated in a nonexicisional regimen.
|
a8b1bfdd-e93b-4d91-9bfe-6254d66a8013
| 0 |
Intraspecific variations in the hemolymph of Biomphalaria glabrata, a snail host of Schistosoma mansoni. An attempt was made to characterize the hemolymph of Biomphalaria glabrata with reference to "normal" intra-specific variation, i.e., both inter- and intra-strain differences. Total protein concentration, per cent hemoglobin, pH, and osmolarity were studied.
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