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8297a76b-458e-4a06-9dac-dd73fc7766a2
| 0 |
Carotid body control of coronary flow, myocardial oxidative metabolism, and cardiac catecholamines in the dog. In a series of 11 dogs, selective stimulation of the carotid body receptors by hypoxic, hypercapnic, acidotic blood produces bradycardia, an increase of coronary flow, and greater release of norepinephrine from the heart; the coronary resistances are decreased. The same stimulation after vagotomy is no longer accompanied by bradycardia; the decrease of coronary resistance is less marked and the release of norephinephrine is increased.
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05427ae6-7e1f-4ecb-871e-bf3a856d14ea
| 0 |
Noradrenergic subsensitivity of rat liver homogenates during chronic ethanol ingestion. Prior studies indicated that chronic ethanol feeding induced noradrenergic subsensitivity of the cerebral cortex. Sensitivity was measured using the cAMP response of brain slices to norepinephrine (NE). In the present report we investigated the possibility that noradrenergic receptors in a visceral organ might be similarly affected by ethanol feeding.
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05427ae6-7e1f-4ecb-871e-bf3a856d14ea
| 1 |
The cAMP response of liver homogenates to NE was measured. Chronic ethanol ingestion induced subsensitivity of the liver to NE similar to that observed in the brain. The ED50 was shifted to the right from 2.1 X 10(-5) M to 1.3 X 10(-4) M NE.
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05427ae6-7e1f-4ecb-871e-bf3a856d14ea
| 2 |
By 3 days of ethanol withdrawal the cAMP response returned to control levels.
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06703552-9e09-42ab-a03b-b5f0e715626c
| 0 |
Interactions between drugs and saliva-stimulating parafilm and their implications in measurements of saliva drug levels. The interaction between Parafilm and four tranquilizers in their neutral phosphate buffer solutions resulted in various degrees of loss of the drugs from the solutions. The values of loss ranged from 15 to 34% for chlorpromazine and 8 to 42% for butaperazine at the initial concentration range of 2 to 20 mug/ml at room temperature (22 +/- 1 degree C).
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06703552-9e09-42ab-a03b-b5f0e715626c
| 1 |
Under the same conditions, the values of loss from saliva for these two drugs were fairly constant; about 25% and 17%, respectively. For diazepam and chlordiazepoxide, the losses from the buffer solution were below 5%.
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340e7282-5b4b-411a-93c1-b9b894e4269f
| 0 |
Acid hydrolases in the odontoblast-predentin region of dentinogenically active teeth. The presence of hyaluronoglucosidase (EC 3.2.1.35; hyaluronidase), beta-N-acetylglucosaminidase (EC 3.2.1.30), exo-1,4-beta-xylosidase (EC 3.2.1.37), and arylsulfatase (EC 3.1.6.1) in dentinogenically active odontoblasts isolated from the rat incisor has been demonstrated by means of biochemical methods. The possible function of these enzymes in relation to the calcification process is discussed.
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b677890f-24b0-483f-9cd2-ed06c88c96b0
| 0 |
N-acetyl-beta-D-hexosaminidase system in synovial fluid. The present study was undertaken with the object of examining the N-Acetyl-beta-D-hexosaminidase activity in joint effusions from non-inflammatory (osteoarthrosis) and inflammatory (rheumatoid arthritis, gouty arthritis and chondrocalcinosis) joint diseases. The biochemical properties of four purified molecular forms were investigated.
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b677890f-24b0-483f-9cd2-ed06c88c96b0
| 1 |
They were separated on the basis of their net charge, using DEAE-cellulose anion-exchangers. In the order of their outcome from the anion exchanger the four enzymes (B, I1, I2 and A) were found to have pH optima at 4.5-4.75, 4.20, 4.00 and 4.75
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b677890f-24b0-483f-9cd2-ed06c88c96b0
| 2 |
, respectively. The first three enzymes proved to be heat-stable and the fourth enzyme fraction was a heat-labile form. By means of gel-filtration techniques, the enzymes were eluted into two fractions. The first contained the thermolabile A form and the molecular weight of this enzyme was estimated at 162000.
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b677890f-24b0-483f-9cd2-ed06c88c96b0
| 3 |
The second fraction included the three thermostable enzymes. Their molecular weight was estimated at 135000. As described by Ikonne & Ellis (6) the hexosaminidase A from sera was less tightly held by the anion-exchanger than was the hexosaminidase A from tissues (polymorphonuclear cells, synovial membrane tissue, cartilage).
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b677890f-24b0-483f-9cd2-ed06c88c96b0
| 4 |
Thus the serum type (As) must be distinct from the tissue type (At). The activity of the tissue type probably originating from the leukocytes and from the synovial membrane was more pronounced in the synovial effusions of the patients with inflammatory joint diseases. The hexosaminidase A fraction from synovial fluids of patients with osteoarthrosis contained only the serum type of enzyme.
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b994327a-a5c5-4bd1-8cb9-3acfaba3c003
| 0 |
[Gastroenterology yesterday and today]. In the 40 years since the foundation of the "Schweizerische Gesellschaft fur Gastroenterologie", medicine - and with it gastroenterology - have markedly changed. New diseases and syndromes have been discovered and others have disappeared. New knowledge in basic sciences influences progress in diagnosis and therapy.
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b994327a-a5c5-4bd1-8cb9-3acfaba3c003
| 1 |
In diagnostic methods the most evident advances are fiberendoscopy, endophotography and biopsy, and progress in roentgenology and immunology. New drugs, new surgical methods and controlled trials have improved treatment. However, each advance has its drawbacks: the growing incidence of iatrogenic diseases, the overwhelming literature, the flood of congresses, the record-breaking mentality of many clinicians and the hunting and collecting instinct for "interesting cases".
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b994327a-a5c5-4bd1-8cb9-3acfaba3c003
| 2 |
"Medical art", a notion difficult to define, is in danger of disappearing. It means a harmony of knowledge, skill experience, intuition and the predominant desire to help the patient. This means individualized medicine, which is only possible by sympathetic dialogue with the patient - not only by specialists in psychiatry or psychosomatics, but by every doctor.
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b994327a-a5c5-4bd1-8cb9-3acfaba3c003
| 3 |
will be able to preserve medicine from inhumanity in spite of technology, rationalization and the computer?
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efcb2dce-2b3e-4637-ad6b-3a629d74f93e
| 0 |
Sperm diaphorase: genetic polymorphism of a sperm-specific enzyme in man. Human sperm contains en enzyme with diaphorase activity that appears to be unique to sperm. Electrophoretic analysis of the diaphorase activity in sperm of different individuals reveals three phenotypic patterns. This polymorphism can be explained in terms of two alleles segregating at an autosomal locus; the allele frequencies have been determined to be 0.71 and 0.29. This appears to be the first reported example of a sperm-specific genetic polymorphism in man; its existence raises a number of genetic and biochemical questions.
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99bb497e-7f38-46ea-abf4-e170358b6a11
| 0 |
Acid precipitation and embryonic mortality of spotted salamanders, Ambystoma maculatum. Spotted salamanders breed in temporary pools formed in early spring by melted snow and rain. Many of these pools reflect the low pH of precipitation in the northeastern United States. Egg mortality is low (less than 1 percent) in pools near neutrality, but high (greater than 60 percent) in pools more acid than pH 6. Developmental anomalies and the embryonic stage at which death occurs are the same in field situations as at corresponding pH's in laboratory experiments.
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bf3056ca-a6bb-4ab3-9c55-99bd6e746a9a
| 0 |
Antibodies to histones and histone-histone complexes: immunochemical evidence for secondary structure in histone 1. Highly specific antibodies were raised to histone 1 (H 1) and the histone complexes H32-H42 AND H2A-H2B, isolated by salt extraction. Antibody to H1 could detect irreversible conformational changes in acid- or urea-treated H1. The antibodies showed different reactivities with chromosomes as compared to antibodies in acid-extracted histones and should be useful in studies of native chromatin and chromosome structure.
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f84272d2-8b54-481c-bffd-0e2e125616e8
| 0 |
Dopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs. Tritiated haloperidol and tritiated dopamine label postsynaptic dopamine receptors in mammalian brain. Clinical potencies of butyrophenones, phenothiazines, and related drugs correlate closely with their ability to inhibit tritiated haloperidol binding. These binding methods provide a simple in vitro means for evaluating new drugs as potential antischizophrenic agents.
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731309a0-a16b-4981-9360-29671291d75f
| 0 |
Vector control of filariasis in the Solomon Islands. In Solomon Islands, filariasis is caused by the nocturnally perodic form of Wuchereria bancrofti and is transmitted by the same vectors of malaria. This study explores the control of this disease as an additional effect of the Malaria Eradication Programme.
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c6744871-372b-4fd3-9f04-79c9510c6f07
| 0 |
Standardisation of the preparation of platelet concentrates. Platelet concentrates with a yield of 80,8% and an absolute number of platelets per pack of 0,86 X 10(11) were obtained, using an optimised harvesting method. This method involved standardised collection of whole blood with constant mixing of blood and anticoagulant, a first centrifugation at 750 g for 6 minutes at 22 degrees C (full brake) and a second centrifugation at 2 0000 g for 20 minutes at 22 degrees C (half brake).
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c6744871-372b-4fd3-9f04-79c9510c6f07
| 1 |
Resuspension of the platelet pellet in plasma was effected by leaving the pack at room temperature for 30 minutes. Platelet concentrates of 25 ml and 50 ml volume displayed satisfactory pH and count characteristics after 72-hour storage both at room temperature and at 2 - 10 degrees C.
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24059573-03f5-4cf3-8192-801b32ba60aa
| 0 |
Suppression of postpartum lactation with furosemide. A regimen of fursemide and moderate restriction of fluid intake was followed in 120 postpartum women to suppress lactation. The methods and results are presented, and possible mechanisms whereby furosemide may suppress lactation are discussed.
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5dc714e9-cf28-4277-a264-9cfc32d372f1
| 0 |
[Changes of protein metabolism following irradiation. II. Protease activity, protease pattern, protein and free amino acids in the cytoplasm and cell organelles of the rat liver following 600 R whole-body irradiation]. The protease activity of cytoplasm and cell organelles of the rat liver against liver protein and hemoglobin as a substrate increases during an initial reaction phase on the first day after 600 R whole body X-irradiation.
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5dc714e9-cf28-4277-a264-9cfc32d372f1
| 1 |
This is probably a consequence of the degradation of cellular debris. The protein, the protease activity and the free amino acids of the cytoplasm and the cell organelles decrease during the disease phase on day 3 and 4 after irradiation. The protein loss of the liver is therefore not explained by an increased protease activity.
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5dc714e9-cf28-4277-a264-9cfc32d372f1
| 2 |
The protease activity and the free amino acids are increased in the cytoplasm and the cell organelles during the regeneration phase of the organism between day 15 and 18 after irradiation.
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c0097209-7bf4-45eb-a9dd-7e8f5641681d
| 0 |
Dynamics of the changes in the tissular levels of cyclic AMP after cobalt-60 gamma-irradiation. The total amounts of cyclic AMP in liver, brain and intestinal mucosa have been measured in rats, at constant intervals, up to 18 days after whole body exposure to either a unique moderate dose (500 rd) or a unique lethal dose (750 rd) of cobalt-60 gamma-radiation.
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c0097209-7bf4-45eb-a9dd-7e8f5641681d
| 1 |
This radiation, even in a lethal dose, was found to induce no significant changes in the hepatic levels of cAMP. In contrast, an abrupt short-lasting increase in the levels of cAMP was observed in brain and intestinal mucosa after a 500-rd-irradiation, and a progressive long-lasting increase in its levels in the intestinal mucosa and, especially, in the brain was found after a 750-rd-irradiation.
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c0097209-7bf4-45eb-a9dd-7e8f5641681d
| 2 |
It is concluded that these organs contain different cAMP systems, which would explain, at least in part, their dissimilar responses to the ionizing rays.
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3e733ad9-020b-41cf-841d-c8c55c8bcf56
| 0 |
Changes in the composition of milk and rumen contents in cows exposed to a high ambient temperature with controlled feeding. Two pairs of Jersey cows were exposed to either 15 or 30 degrees C air temperature; intake of dried grass was controlled, to be equal at both temperatures. Exposure to 30 degrees C caused increases in rectal temperature and in respiratory rates, and decreases infood intakes in both cows.
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3e733ad9-020b-41cf-841d-c8c55c8bcf56
| 1 |
Milk yield decreased by similar amounts at both temperatures, in association with the decreases in food intakes. The fat and protein content of milk decreased significantly at 30 degrees C; the proportion of shorter chain fatty acids (C6-C14) IN THE milk fat also decreased at 30 degrees C.
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3e733ad9-020b-41cf-841d-c8c55c8bcf56
| 2 |
The proportion of acetic acid in the rumen contents decreased significantly at 30 degrees C, in association with a small decrease in pH. The results indicate that changes in the metabolism of cows occurred at 30 degrees C, independently of changes in food intake.
|
6c1d4cb0-8585-41e5-b697-25ee9632b2c5
| 0 |
Brain microvascular hemodynamic responses to induced seizures. Arteriolar diameters and venular erythrocyte velocities in the small pial vessels on the surface of the cat brain were measured by TV methods during induced epileptic seizures through a cranial window. Grand mal seizures maximally dilated arterioles and increased venular erythrocyte velocity up to 400%. High positive correlation existed between changes in CSF hydrogen ion concentration and pial arteriolar diameter, suggesting metabolic regulation of CBF through CSF/interstitial fluid hydrogen ion alterations during the seizure.
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38f3561c-365b-4e2e-ac7e-8c93ef2215ad
| 0 |
[Characteristics of heterogeneity of serum albumin in heterosis-hybrid chickens]. A comparative study was performed for isoelectric and electrophoretic spectra blood serum albumin of parental breeds of chickens and their heterosis hybrids --broiler cocks. The method of isoelectric focusing within the surcrose density gradient and pH 4-6 created by the gradient of sucrose, mannitol and boron-borate buffer (pH 8.5
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38f3561c-365b-4e2e-ac7e-8c93ef2215ad
| 1 |
) concentrations was applied. The electrophoretic spectrum of the serum albumin fraction homogeneous in the agar gel was obtained by electrophoresis in 7% polyacrylamide gel. The isoelectric spectrum of heterosis hybrid albumin is established to be more heterogeneous and during isoelectric focusing it is divided within a range of pH 4.6
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38f3561c-365b-4e2e-ac7e-8c93ef2215ad
| 2 |
-5.2 into seven fractions against four-five components of the parent breed albumin. Among them it is possible to distinguish the fraction involving more than 50% of the total protein (the great component) and some small components with different protein content and belonging wither to a more acid or more basic region as compared to pI of the great component.
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38f3561c-365b-4e2e-ac7e-8c93ef2215ad
| 3 |
The pI value of the great component for hybrid albumin is shifted towards the acid region (4.76 against 4.85 and 5.07 in albumin of the parent breeds). Small component of hybrid albumin are characterized by an increase in their amount, but pI of the fraction is within the range of values peculiar to albumin of the maternal and paternal lines.
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38f3561c-365b-4e2e-ac7e-8c93ef2215ad
| 4 |
The albumin preparations of all the studied chicken breeds isolated from blood serum by electrophoresis in the agar gel manifest multiplicity of the protein bands in a 7% polyacrylamide gel. The electric spectra of hybrid albumin and parent breeds albumin differ in the distribution pattern of the components and their quantitative composition.
|
38f3561c-365b-4e2e-ac7e-8c93ef2215ad
| 5 |
A relative electrophoretic mobility of the intensively stained dense band which represents the main electrophoretic component is increased in hydrid albumin with the respect to albumin of the maternal line but is identical to the paternal line.
|
a94a79d0-746a-402c-877f-f76cc03f8bcd
| 0 |
Metomidate as sole anaesthetic agent in tawny owls. Metomidate 1 per cent was administered intramuscularly as the sole anaesthetic agent on 22 occasions to seven tawny owls (Strix aluco). Four deaths occurred, none on the first administration. ECG findings and details of dosage are provided. The possible causes of death are discussed.
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b2980cd5-2439-4f25-b333-6306139cd4ca
| 0 |
[Peculiarities of acid-base reserves in aging]. The age-dependent peculiarities of the acid-base balance at rest and with standard loads were studied in 466 rats. It was found that with age the pH value of blood decreases, the tension of the carbonic acid increases, but the values of BB, BE, SB, and AB do not undergo any significant changes.
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b2980cd5-2439-4f25-b333-6306139cd4ca
| 1 |
With loads, old animals showed more profound changes in the system and these changes were of decompensated character. The maximal changes in young animals were registered 1.5 hours after loading, in old rats--3 hours after. The normalization of the shifts in old rats occurred much more slowly than in young animals, and it does not reached the initial value by 24 hours after loading.
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b2980cd5-2439-4f25-b333-6306139cd4ca
| 2 |
The analysis of the data obtained shows that with aging the reserve potentialities of the organism's mechanisms of the acid-base balance regulation greatly decrease, which under certain conditions results in disturbance of the given system compensation, thus exerting a negative effect on the body vital processes.
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fac0e8c7-de53-4abc-9c00-3e27f6972fd8
| 0 |
[Dynamics of production and various properties of interferon-like inhibitors formed under the influence of AET and cystaphos in vivo and in cell cultures]. Interferon-like virus inhibitors appeared in the blood serum of animals and in the culture fluid 15 min.--1 hour and 4-6 hours after administration of AET (S, beta-amino-ethylisotiuronium) and cystaphos (monosodium salt of beta-aminoethylthiophosphorus acid).
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fac0e8c7-de53-4abc-9c00-3e27f6972fd8
| 1 |
These inhibitors showed species-specificity, were inactivated by trypsin and by heating at 37 degrees C for 2 hours and at 56 degrees C for 1 hour, did not sediment at 100,000 g. It is assumed that these are two different inhibitors of which the one forming the early peak pre-exists in the cell.
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fac0e8c7-de53-4abc-9c00-3e27f6972fd8
| 2 |
It is probably associated with cell membranes and is released as a result of chemical effect of aminothyols. The late peak of inhibitor is synthesized de novo as inducated by its sensitivity to the effect of puromycin and cycloheximide.
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aaee5bc3-3165-4f34-92bf-9128a3079157
| 0 |
[Lipolysis in human adipose tissue (author's transl)]. Lipolytic activity was measured under different conditions in isolated fat cells and homogenates of human adipose tissue of the greater omentum. It was demonstrated that lipolysis took place in isolated fat cells at an optimum pH of 7.4 and was markedly stimulated by noradrenaline, but not by blood serum.
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aaee5bc3-3165-4f34-92bf-9128a3079157
| 1 |
By contrast lipolysis was significantly stimulated by blood serum, but not by noradrenaline, in homogenates of adipose tissue. Serum-stimulated lipolysis exhibited optimum activity at pH 8 and was inhibited by 1M sodium chloride. It is concluded that lipolytic activity in isolated fat cells can mainly be ascribed to the action of hormone-sensitive lipase, whereas lipolysis in homogenates of adipose tissue in the presence of serum is mostly regulated by lipoprotein lipase.
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c90ccb53-3341-4170-ac7a-c5d68f6ee3b8
| 0 |
[Study of the influence of the beta-sympatholytic drug KO 1366 (Bunitrolol on lung function (author's transl)]. 20 untreated outpatients suffering from chronic obstructive airway disease were tested with a new beta-sympatholytic agent, Kö 1366 (bunitrolol) or placebo in a randomized symptoms of bronchitis, but hacetylcholine inhalation was followed by severe bronchospastic hyperreactivity.
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c90ccb53-3341-4170-ac7a-c5d68f6ee3b8
| 1 |
The intravenous administration of 2.5 mg Kö 1366 resulted in a rapid and statistically significant (p less than 0.001) marked decrease in heart rate due to the beta-sympatholytic effect. Airway resistance, however, measured by whole-body plethysmography, was not affected. Kö 1366 can be regarded as a cardio-selective beta-sympatholytic drug in so far as i.
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c90ccb53-3341-4170-ac7a-c5d68f6ee3b8
| 2 |
v. administration is possible in patients with airway disease during a non-obstructive period. Moreover, should a bronchospastic reaction occur immediate control by inhalation of adrenergic or vagolytic drugs is possible.
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512e4dfd-7d46-42b4-96a5-afa18fa1f3a8
| 0 |
[Cerebral manifestations in the hepatic coma syndrome (author's transl)]. The pathogenesis of hepatic encephalopathy has been investigated in a two-stage devascularization model in the rat with portavacal shunt and hepatic artery ligation. There is a significant increase in brain octopamine and phenylethanolamine and a decrease in brain norepinephrine (NE) 6 to 9 hours after hepatic artery ligation.
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512e4dfd-7d46-42b4-96a5-afa18fa1f3a8
| 1 |
The depletion of NE seems the sequel of diminished synthesis in the presence of an unaltered turnover rate, due to a blockade of tyrosine hydroxylase either by accumulation of false neurochemical transmitters or by phenylalanine. It is most marked in the cortex and midbrain. The high-energy phosphate compounds, ATP, phosphocreatine and glucose-6-phosphate are not diminished in hepatic coma, nor is glucose, indicating that other mechanism are involved in the pathogenesis of metabolic state by the increased ammonia level.
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512e4dfd-7d46-42b4-96a5-afa18fa1f3a8
| 2 |
"intestinal sterilization" and total colectomy have no significant effect on the ammonia level, but cause a decrease in the level or aromatic precursor amino acids in the plasma and brain, with normalization of the level of cerebral transmitters. These results permit the formulation of a unified concept of the hepatic coma syndrome and its clinical manifestations such as flapping tremor, the hyperdynamic cardiovascular state and the hepatorenal syndrome.
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512e4dfd-7d46-42b4-96a5-afa18fa1f3a8
| 3 |
Moreover, they form the basis for the introduction of a new therapeutic principle in the management of hepatic encephalopathy by L-dopa or modified amino acid solutions, which act by altering the central and peripheral neurotransmitters.
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f9248ee2-3116-4d3f-ab7a-52f93b2adc09
| 0 |
[Urinary enzymes in the early detection of rejection reactions after renal transplantation (author's transl)]. Urinary enzymes were studied in 15 patients subjected to kidney transplantation. The investigation was initiated immediately after operation and was continued for a period of between 2 and 8 weeks. There was a significant increase in urinary MDH activity in 94.2
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f9248ee2-3116-4d3f-ab7a-52f93b2adc09
| 1 |
% of cases, of LDH activity in 95,65% and of gamma-GT activity in 95,17% of the cases. This detected increase in urinary enzyme activities preceded the clinical diagnosis of rejection by activities preceded the clinical diagnosis of rejection by at least 24 hours. Determination of these enzymes provides a reliable tool for the early detection of rejection crises.
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e442f5ab-dfa5-4e09-ac55-b913d8b8b6f1
| 0 |
[Extracardiac factors in the development of arrhythmias (author's transl)]. A brief survey is given of some of the most frequent extracardiac causes which may provoke disturbances of rhythm. The importance of psychogenic and metabolic factors is emphasized. Additional organic lesions cannot be excluded in every case.
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2497d8f4-232c-4fd9-8854-d3489f92d5b0
| 0 |
[Inducible accumulation of alpha-ketoglutaric acid in cultures of Streptomyces hygroscopicus JA 6599 producing a macrolide antibiotic]. The excessive production of pyruvic and 2-oxoglutaric acid by S. hygroscopicus JA 6599 grown on a medium rich in complex carbon and nitrogen sources was studied. Towards the end of the first day of batch cultivation a maximum level of both keto acids in the medium was observed.
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2497d8f4-232c-4fd9-8854-d3489f92d5b0
| 1 |
By diluting the complete culture with water at 22nd hour, however, a further increase in 2-oxoglutarate concentration was induced and the antibiotic production was slightly stimulated. In diluted cultures the oxygen saturation was found to be distinctly higher than in non-diluted ones and, on the other hand, the mycelial activities of both pyruvate and 2-oxoglutarate decarboxylases were decreased.
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2497d8f4-232c-4fd9-8854-d3489f92d5b0
| 2 |
Since the 2-oxoglutarate level was strongly influenced by inhibitors of glycolysis and of citric acid cycle, it is suggested that the metabolite accumulation in diluted cultures is mainly caused by modifications of the metabolic control of carbohydrate catabolism due to an improved aeration. Furthermore, the macrolide antibiotic A 6599 produced by S.
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2497d8f4-232c-4fd9-8854-d3489f92d5b0
| 3 |
hygroscopicus JA 6599 itself was shown to interfere with the accumulation of 2-oxoglutaric acid.
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29d8e04e-8f6b-4c4f-a10b-4c173375144c
| 0 |
[Immunosuppressive treatment in autoimmune vasculities]. From own experiences the observations of 3 patients were reported who were immunosuppressively treated with purine antagonists (azathioprine and 6-mercaptopurine). Hereby in a severe allergic vasculitis in a 22-year-old patient and in a granulomatous arteritis during Wegener's granulomatosis in a 51-year-old patient remissions for more than 1 and 7 years, respectively, could be achieved under immunosuppressive long-term therapy. In the case of a periarteriitis nodosa death took place 2 months after administration of 6-mercaptopurine.
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2cd34c97-f012-4ab5-b169-013893c64225
| 0 |
[Possibilities and limits of the intrauterine reanimation (author's transl)]. Intrauterine reanimation means the removal of acute maternal or fetal distress. Beside of maternal shock (traumatic, hoaemorrhagic, supine hypotension syndrome) all acute distress situation are seen during labour. The therapeutical possibilities and premises on the one side, the limits and dangers on the other are discussed.
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2cd34c97-f012-4ab5-b169-013893c64225
| 1 |
There are the change of position in bed, infusion of low molecular dextrane, O2- breathing, buffering of the mother, infusion of vasodilatators and beta-stimulators to the mother. The main therapeutical principle for intrauterine reanimation are change of side position and beta-stimulator therapy in case of disturbances in feto-maternal respiration because of an acute utero-placental insufficiency or a cord complication.
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2cd34c97-f012-4ab5-b169-013893c64225
| 2 |
As to an own patient group with intrauterine reanimation with the beta-stimulator "Partusisten" in 174 deliveries with cardiotocographic signs of fetal distress in the first stage of labour there is shown that threatened fetal distress because of uterine hyperactivity and cord complication is successfully treated by tocolysis. In case of chronic placental insufficiency there is no therapeutical success by intra partum tocolysis in 30%.
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f21a6da6-e2b5-468b-b6b5-bada0fb8a1a0
| 0 |
Graft-versus-host reaction: a pathogenetic principle for the development of drug allergy, autoimmunity, and malignant lymphoma in non-chimeric individuals. Hypothesis. It is proposed that the same diseases as those induced by the graft-versus-host reaction (GVHR) will arise in nonchimeric individuals, if structures of the major histocompatibility complex (MHC) on lymphocytes are altered, either by viral infection or by chemicals, in such a way that autologous T lymphocytes react against them as the react in the GVHR to semiallogeneic (F1) lymphocytes differing at the MHC.
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f21a6da6-e2b5-468b-b6b5-bada0fb8a1a0
| 1 |
Diseases in which a GVHR-like pathogenesis is suspected will be discussed.
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bbda3b5d-29d2-4811-be49-9864f0a3032f
| 0 |
[Studies on the hatching of miracidia of Dicrocoelium dendriticum (author's transl)]. The eggs of Dicrocoelium dendriticum were induced to open by solutions of formic acid and caproic acid (Table 1). The miracidia hatched in O2-free water after the eggs had been dried with N2 or in vacuum.
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bbda3b5d-29d2-4811-be49-9864f0a3032f
| 1 |
The miracidia were able to live for 3 hours if water contained 20 mM NaCl, 10 mM KCl, and 1 mM CaCl2. Ca++-ions are obviously necessary for the mobility of miracidia. The experimental use of intestinal juice of the Roman snail Helix pomatia gave hatching results which were dependent on the absence of O2 (exposure to N2) and the presence of bacteria with a still unknown function.
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bbda3b5d-29d2-4811-be49-9864f0a3032f
| 2 |
The dependence on pH seems to be indirect (Abb. 2). Studies on the permeabilities of the egg shell and the embryonic membrane ("vitelline membrane"), the evidence of an oligosaccharide (Abb. 3) liberated from the "spaltraum" (Abb. 1) during egg-opening, and the determination of the osmotic pressure of the hatching process (50% hatching in 1.2--14. Osmols sucrose/1000 ml H2O; Abb. 4)
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bbda3b5d-29d2-4811-be49-9864f0a3032f
| 3 |
led to the following hypothesis of hatching mechanism: After the activation of the granular gland of the miracidium an enzyme is released into the extra-embryonic "spaltraum". A polysaccharide is digested to an oligosaccharide which cannot permeate the egg shell and the embryonic membrane. The rising osmotic pressure bursts off the operculum.
|
fa795ca0-70ec-4776-8572-7dc4b01f3bcf
| 0 |
[Long-term treatment of chronic polyarthritis using benorylate]. The antiphlogistic and analgesic effect and the compatibility of benorylate, a acetamidophenyl-acetoxy-benzoate, was tested in 33 patients with rheumatoid arthritis in an open study over a period of 6 months. Benorylate is particularly qualified for treatment of a beginning rheumatoid arthritis and for diseases with a low inflammatory activity.
|
fa795ca0-70ec-4776-8572-7dc4b01f3bcf
| 1 |
For patients with high inflammatory activity treatment with this substance alone is not sufficient. Side effects are mainly subjective troubles. Severe side effects were not observed. Besides the usual laboratory investigations a regular control of the blood count is advisable during long term treatment. Like with other antirheumatic drugs occasional investigations of the stool for occult blood are recommended.
|
bb461d02-fe2d-404b-b167-dc757130f7dc
| 0 |
[Studies of Nocardia pellegrino SN 5108 pigment mutants: reasons for differences in pigmentation (author's transl)]. Yellow and white mutants of the strains Nocardia pellegrino SN 5108 R have been isolated. Regarding their morphological and physiological properties, the mutants are identical with the wild type bacteria with the exception of their pigmentation and lipid composition.
|
bb461d02-fe2d-404b-b167-dc757130f7dc
| 1 |
However, the pigment composition (number, Rf-values and spectra of the pigment components) of the yellow mutant is identical with that of the wild type; as a consequence, the modified pigmentation of the yellow mutant cannot be explained by an altered pigment synthesis. The wild type cells and the mutant SN 5108 G contain three main pigment components designated as I, II and III.
|
bb461d02-fe2d-404b-b167-dc757130f7dc
| 2 |
Components II and III posses a marked indicator character and show a bathochromic shift in solutions of pH 12 or higher. Components II and III contain functional groups which are able to react with acetic acid yielding acetylated products; after acetylating, no bathochromic shift in alkali occurs. Intact cells of the wild type retain their orange-red pigmentation in buffer solution with a pH-value of 12 or higher.
|
bb461d02-fe2d-404b-b167-dc757130f7dc
| 3 |
Cells of the yellow mutant, however, change the yellow color immediately after the alkali treatment to orange-red; this new color is identical with that of the wild type and can be changed to yellow by placing the cells into 1 N HCl. Regarding these facts it seems to be very probable that the functional groups of the pigment components II and III are differently bound in the wild type and mutant cells.
|
bb461d02-fe2d-404b-b167-dc757130f7dc
| 4 |
In the mutant, they are accessible to OH- ions yielding a bathochromic shift while in the wild type cells, OH- ions are unable to provoke this shift. It seems to be also probable that different lipids in the two strains are responsible for the binding of the pigments.
|
bb461d02-fe2d-404b-b167-dc757130f7dc
| 5 |
So far known, this is the first observation about the occurence of pigment mutants with an altered pigment binding site in the cells.
|
e2110af9-6c66-4d36-9423-dc365ef06326
| 0 |
Formation and some factors influencing the activity of progesterone hydroxylases by Aspergillus niger. The formation of progesterone hydroxylases by Aspergillus niger 173 was investigated. The constitution of the fermentation medium influenced both the yield and the type of enzymes catalyzing the transformation of progesterone. The enzyme yield also varied with the pH value at which induction was performed as well as with the buffer used.
|
e2110af9-6c66-4d36-9423-dc365ef06326
| 1 |
The transformation activity of progesterone was more pronounced with mycelia induced in citrate-phosphate than in phosphate buffer. The results demonstrated that induction of 6beta-hydroxylase was favoured at pH values near neutrality while that of 11alpha-hydroxylase in the presence of citrate ions. The transformation activity of progesterone was optimal at pH 5.0
|
e2110af9-6c66-4d36-9423-dc365ef06326
| 2 |
. The action of 11alpha-hydroxylase was also optimal at pH 5.0, but other hydroxylase showed pH optima between 2.2 and 4.0. Progesterone concentrations higher than 6 mg in 50 ml reaction mixture was a limiting factor for the rate of transformation activity.
|
ba6b4b95-38f3-4deb-8d9c-612484293a5c
| 0 |
[Preparation of the lectin B component from the hemagglutinin of Lens culinaris]. Out of a mixture of both lectins of the lentil (Lens culinaris) the component B may be separated rapidly and easily because of the different temperature sensitivity of haptene protected isolectins A and B.
|
edecea22-2c32-46fe-a6bd-38cfa2fa25ed
| 0 |
Alanine formation and alanine aminotransferase activity in the nerve tissue with proliferating macroglia. In the nerve tissue with proliferating macroglia cells were observed a lowered oxygen consumption, an increased aerobic glycolysis and alanine formation and a higher alanine aminotransferase and glutamate dehydrogenase activity than in the control tissue in the homogenates and in the cell sap fraction.
|
edecea22-2c32-46fe-a6bd-38cfa2fa25ed
| 1 |
The substrate saturation curves, apparent Km and pH optimum values in the tissue with proliferating macroglia and in the control did not differ from one another. The authors assume that a higher alanine aminotransferase activity in the tissue with macroglia proliferation can reflect either a higher synthesis of the enzyme in the altered tissue, or a predominance of glial elements in the altered tissue possessing a higher alanine aminotransferase activity than the nerve cells.
|
e95c270e-9a72-4afd-8635-2a8aa3fd911a
| 0 |
Influence of sugar content in soft bread on pH of human dental plaque. Quantitative determination of monosaccharides, disaccharides and sorbitol by use of gas-liquid chromatography (GLC) was performed on thirty-three samples of different commercial soft bread. Maltose was found in all the bread samples. Fructose and glucose were found only in samples of sweetened bread.
|
e95c270e-9a72-4afd-8635-2a8aa3fd911a
| 1 |
Sucrose was detected in 5 samples, lactose in 2, and sorbitol in 2. Up to 20 per cent of the fresh bread weight was found to be low-molecular weight carbohydrates. Plaque pH-changes were studied in 18 persons following a 30-second month rinse with each of 3 solutions:
|
e95c270e-9a72-4afd-8635-2a8aa3fd911a
| 2 |
(1) 50% sucrose, (2) water extract of sweetened bread, and (3) water extract of unsweetened bread. Mouth rinsing with the extract of sweetened wheat bread (sucrose 7.7 per cent of the dough weight) caused pH-decreases in plaque which were significantly more pronounced than those induced by the water extract of unsweetened wheat bread.
|
376ac9e3-78b6-482b-9a85-db79a48ae018
| 0 |
Preliminary study of parenteral lorazepam in status epilepticus. The authors report their experience with parenteral lorazepam in the acute treatment of 11 patients with EEG-confirmed status epilepticus. Ten adults and one 6-year-old child were injected respectively with 5 mg and 2.5 mg lorazepam. All of these patients exhibited prompt cessation of seizures both electrical and clinical. Some data indicate a longer lasting relief than that provided by an equal dose of diazepam.
|
562f4bad-4559-4aed-8cd2-0168a53637cc
| 0 |
Structure-basicity and structure-affinity relationships of beta-adrenergic blocking agents. pKa's of fourteen beta-receptor blockers, isoproterenol and norepinephrine, were determined potentiometrically. A Hammett analysis indicated that the influence of ring substituents on the basicity of the amines is attenuated by the ethanolic chain and abolished by the propranoloxy chain of beta-receptor blockers. The effect of ring substituents in phenoxypropranolamines upon affinity for the beta-adrengeric receptors is therefore unrelated to the strength of the bases. Two alterantive hypotheses are fowarded to explain why phenoxypropranolamines have greater affinities for the beta-receptors than phenethanolamines.
|
d122d2b4-39d7-4428-b156-b2e2dabf6a08
| 0 |
Inhibition by acidosis of adenosine 3',5'-cyclic monophosphate accumulation and lipolysis in isolated rat fat cells. Lipolysis and cyclic AMP accumulation were studied in isolated rat fat cells at normal (7.4) and decreased (7.0, 6.6) pH. Acidosis inhibited lipolysis and cyclic AMP accumulation due to NA non-competetively.
|
d122d2b4-39d7-4428-b156-b2e2dabf6a08
| 1 |
Maximal lipolysis (3 muM NA) was inhibited by 25% at pH 7.0 and by 61% at pH 6.6 Cyclic AMP accumulation 5 min after 3 muM NA was inhibited by 57% at pH 7.0 and by 83% at pH 6.6. Between 10 and 60 minutes of incubation NA-stimulated lipolysis was linear at pH 7.4
|
d122d2b4-39d7-4428-b156-b2e2dabf6a08
| 2 |
, whereas a progressively increasing inhibition was seen at lower pH. The FFA production was inhibited to the same degree as glycerol production by acidosis. The fraction of FFA associated with the cells was the same at all pHs. Thus, we have no evidence that acidosis inhibits lipolysis via accumulation of FFA intracellularly.
|
d122d2b4-39d7-4428-b156-b2e2dabf6a08
| 3 |
NA-induced accumulation of 3H-cAMP from 3H-ATP, endogenously formed by prelabelling the cells with 3H-adenine, was inhibited by acidosis both in the presence and absence of theophylline in the incubation medium (by 48 and 44% respectively at pH 7.0 and by 74 and 68% at pH 6.6
|
d122d2b4-39d7-4428-b156-b2e2dabf6a08
| 4 |
). Cyclic nucleotide phosphodiesterase in homogenates of fat cells was inhibited by decreasing the pH, whether measured at high or low substrate concentrations. Basal adenylyl cyclase activity in a cell membrane fraction from fat cells was affected to a minor degree, while NA-stimulated activity was inhibited by decreased pH.
|
d122d2b4-39d7-4428-b156-b2e2dabf6a08
| 5 |
The response to 3 muM NA at pH 6.6 was inhibited by 43% relative to control. The results show that acidosis inhibits NA-induced cyclic AMP accumulation by interfering with the formation, rather than the inactivation of the nucleotide. Since NA-induced lipolysis is a cyclic AMP-mediated process it is suggested that at least part of the antilipolytic effect of acidosis is due to inhibition of cyclic AMP formation.
|
a79f2648-f118-4755-b071-acbed8aad2c0
| 0 |
Cyclic AMP-dependent and independent inhibition of lipolysis by adenosine and decreased pH. NA-stimulated lipolysis and cAMP formation in isolated rat fat cells is inhibited by acidosis. In the present report we have examined the quantitative relationship between lipolysis and cAMP formation at normal and reduced pH and the possible involvement of adenosine, an endogenous inhibitor of cAMP formation.
|
a79f2648-f118-4755-b071-acbed8aad2c0
| 1 |
Adenosine antagonized cAMP accumulation and to a considerably lower degree lipolysis, effects potentiated by acidosis. Theophylline, an antagonist of adenosine effects, stimulated lipolysis and cAMP-accumulation, and potentiated responses to NA. Adenosine deaminase (ADA) had theophylline-like effects. Acidosis inhibited lipolysis and cAMP accumulation induced by ADA and theophylline to a larger extent than those induced by NA.
|
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