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9.4k
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DB00807
|
Proparacaine
|
Proparacaine is a topical anesthetic drug of the amino ester group. It is found in ophthalmic solutions at a concentration of 0.5% as the hydrochloride salt.
|
solid
|
Used as a local (ophthalmic) anesthetic.
|
Proparacaine stabilizes the neuronal membrane by inhibiting the ionic fluxes required for the initiation and conduction of impulses thereby effecting local anesthetic action. More specifically, proparacaine appears to bind or antagonize the function of voltage gated sodium channels.
|
The exact mechanism whereby proparacaine and other local anesthetics influence the permeability of the cell membrane is unknown; however, several studies indicate that local anesthetics may limit sodium ion permeability through the lipid layer of the nerve cell membrane. Proparacaine may alter epithelial sodium channels through interaction with channel protein residues. This limitation prevents the fundamental change necessary for the generation of the action potential.
| null |
Plasma
| null | null | null | null | null | null |
Organic compounds
|
Benzenoids
|
Benzene and substituted derivatives
|
Benzoic acids and derivatives
|
[
"approved",
"vet_approved"
] |
[
"S01HA",
"S01H",
"S01",
"S"
] |
[
"Humans and other mammals"
] |
[
{
"cost": "1.02",
"description": "Ophthetic 0.5% eye drops",
"unit": "ml"
},
{
"cost": "1.27",
"description": "Proparacaine 0.5% eye drops",
"unit": "ml"
},
{
"cost": "2.19",
"description": "Alcaine 0.5% eye drops",
"unit": "ml"
},
{
"cost": "14.99",
"description": "Proparacaine HCl 0.5% Solution 15ml Bottle",
"unit": "bottle"
},
{
"cost": "84.0",
"description": "Proparacaine hcl powder",
"unit": "g"
},
{
"cost": "0.68",
"description": "Alcaine 0.5 % Solution",
"unit": "ml"
}
] |
[] |
Proximetacaina | Proxymetacaine | Proxymetacainum | hPN3 | Peripheral nerve sodium channel 3 | PN3 | Sodium channel protein type X subunit alpha | Voltage-gated sodium channel subunit alpha Nav1.8
|
[
"Alcaine",
"Alcaine",
"Alcaine",
"Flucaine",
"Fluorescein Sodium and Proparacaine Hydrochloride",
"Mydriatic-4",
"Odan-fluoracaine",
"Odan-proparacaine",
"Ophthetic",
"Ophthetic",
"Ophthetic",
"PMS-proparacaine Hydrochloride Oph Soltn 0.5%",
"Proparacaine",
"Proparacaine Hydrochloride",
"Proparacaine Hydrochloride",
"Proparacaine Hydrochloride",
"Proparacaine Hydrochloride",
"Proparacaine Hydrochloride",
"Proparacaine Hydrochloride",
"Proparacaine Hydrochloride",
"Proparacaine Hydrochloride",
"Proparacaine Hydrochloride",
"Proparacaine Hydrochloride",
"Proparacaine Hydrochloride",
"Proparacaine Hydrochloride",
"Proparacaine Hydrochloride",
"Proparacaine Hydrochloride",
"Proparacaine Hydrochloride",
"Proparacaine Hydrochloride",
"Proparacaine Hydrochloride",
"Proparacaine Hydrochloride",
"Proparacaine Hydrochloride",
"Proparacaine Hydrochloride",
"Proparacaine Hydrochloride",
"R.O.-parcaine Dps 5mg/ml"
] |
[
"Ak-Taine",
"Diocaine",
"Ocu-Caine",
"Ophthaine",
"Spectro-Caine"
] |
[
"Mydriatic-4",
"Fluorescein Sodium and Proparacaine Hydrochloride",
"Flucaine",
"Odan-fluoracaine"
] |
[
"Q9Y5Y9"
] |
[] |
[] |
[] |
DB00813
|
Fentanyl
|
Fentanyl, a potent opioid agonist, was developed in the 1950s to fill a need for strong and rapid analgesia.[A179542] Because of these characteristics, fentanyl is commonly used to treat chronic cancer pain or in anesthesia.[Label,L6598,L6601,L6604,L6607,L922,L6610,L6613] Fentanyl is related to other opioids like [morphine] and [oxycodone].
Fentanyl's high potency has also made it a common adulterant in illicit drugs, especially heroin.[A179542] In 2017, 47600 overdose deaths in the United States involved some opioid (over 2/3 of all overdose deaths).[L6748] Opioid overdoses kill an average of 11 Canadians daily.[L6751]
Fentanyl was FDA approved in 1968.[Label,L6598,L6601,L6604,L6607,L922,L6610,L6613]
|
solid
|
Fentanyl intravenous or intramuscular injections are indicated for short term analgesia during induction, maintenance, and recovery from general or regional anesthesia.[Label] These injections are also used with a neuroleptic for premedication, induction, and as an adjunct to maintenance of anesthesia.[Label] Finally, fentanyl intravenous or intramuscular injections are used with oxygen for anesthesia in high risk patients.[Label]
Fentanyl sublingual tablets, transmucosal lozenges, buccal tablets, sublingual sprays, transdermal systems, and nasal sprays are indicated for the management of breakthrough pain in opioid tolerant cancer patients who require around the clock pain management.[L6598,L6601,L6604,L6607,L922,L6610]
|
Fentanyl produces strong analgesia through its activation of opioid receptors.[Label,A179533] It has a duration of action of several hours and a wider therapeutic index as patients develop tolerance to opioids.[Label] Fentanyl is associated with a risk of addiction and abuse and should not be mixed with alcohol or benzodiazepines.[Label,L6598,L6601,L6604,L6607,L922,L6610,L6613]
|
Fentanyl binds to opioid receptors, especially the mu opioid receptor, which are coupled to G-proteins.[A179533] Activation of opioid receptors causes GTP to be exchanged for GDP on the G-proteins which in turn down regulates adenylate cyclase, reducing concentrations of cAMP.[A179533] Reduced cAMP decreases cAMP dependant influx of calcium ions into the cell.[A179533] The exchange of GTP for GDP results in hyperpolarization of the cell and inhibition of nerve activity.[A179533]
|
Fentanyl sublingual tablets are 54% bioavailable[L6598], transmucosal lozenges are 50% bioavailable[L6601], buccal tablets are 65% bioavailable[L6604], sublingual spray is 76% bioavailable[L6607], and nasal spray is 20% more bioavailable than transmucosal[L6610] (or approximately 64% bioavailable).
Fentanyl transmucosal lozenges reach a C<sub>max</sub> of 0.4±0.1ng/mL for a 200µg dose and 2.5±0.6ng/mL for a 1600µg dose with a T<sub>max</sub> of 20-40 minutes.[A179644] The AUC was 172±96ng\*min/mL for a 200µg dose and 1508±1360ng\*min/mL for a 1600µg dose.[A179644]
Fentanyl sublingual spray reached a C<sub>max</sub> of 0.20±0.06ng/mL for a 100µg dose and 1.61±0.60ng/mL for an 800µg dose with a T<sub>max</sub> of 0.69-1.25 hours, decreasing as the dose increased.[A179647] The AUC was 1.25±0.67ng\*h/mL for a 100µg dose and 10.38±3.70ng\*h/mL for a 800µg dose.[A179647]
Fentanyl transdermal systems reached a C<sub>max</sub> of 0.24±0.20ng/mL with a T<sub>max</sub> of 3.6±1.3h for a 25µg/h dose.[A179653] The AUC was 0.42±0.35ng/mL\*h.[A179653]
Fentanyl nasal spray reaches a C<sub>max</sub> of 815±301pg/mL with a T<sub>max</sub> of less than 1 hour for a 200µg/100µL dose.[A179656] The AUC was 3772pg\*h/mL.[A179656]
|
Fentanyl is metabolized to a number of inactive metabolites.[A178639] Fentanyl is 99% N-dealkylated to norfentanyl by cytochrome P450.[A178639] It can also be amide hydrolyzed to despropionylfentanyl, or alkyl hydroxylated to hydroxyfentanyl which is N-dealkylated to hydroxynorfentanyl.[A178639]
|
Fentanyl has an intravenous LD<sub>50</sub> of 2.91mg/kg in rats[A1220], an oral LD<sub>50</sub> of 18mg/kg in rats and 368mg/kg in mice.[MSDS] The LD50 in humans is not known.
Symptoms of overdose include respiratory depression, somnolence, stupor, coma, skeletal muscle flaccidity, cold and clammy skin, pupillary constriction, pulmonary edema, bradycardia, hypotension, airway obstruction, atypical snoring, and death.[Label,L6598,L6601,L6604,L6607,L922,L6610] In case of overdose, patients should receive naloxone or nalmefene to reverse the action of the opioids as well as supportive measures to maintain the airway or advanced life support in the case of cardiac arrest.[Label,L6598,L6601,L6604,L6607,L922,L6610]
|
The half life of fentanyl is 7 hours.[L6601] The half life of fentanyl sublingual spray is 5-12 hours.[L6607]
|
Fentanyl is 80-85% bound to plasma proteins.[L6598,L6601,L6604,L6607,L6610] In one study, a 0.1µg/L solution of fentanyl was 77.9±1.1% bound to human serum albumin and 12.0±5.4% bound to α-1 acid glycoprotein.[A179536] A 0.1µg/L solution of norfentanyl, the primary metabolite of fentanyl, was 7.62±1.2% bound to human serum albumin and 7.24±1.9% bound to α-1 acid glycoprotein.[A179536]
|
Within 72 hours, 75% of a dose of fentanyl is excreted in the urine with <7% unchanged, and 9% is excreted in the feces with <1% unchanged.[Label,L6598,L922]
|
The intravenous volume of distribution is 4L/kg (3-8L/kg)[Label,L922]. The oral volume of distribution is 25.4L/kg.[L6604] In hepatically impaired patients, the intravenous volume of distribution ranges from 0.8-8L/kg.[L922]
Fentanyl crosses the blood brain barrier[A179632] and the placenta.[A179635]
|
Total plasma clearance of fentanyl is 0.5L/hr/kg (0.3-0.7L/hr/kg)[L6601] or 42L/hr.[L6604,L6610] Following an intravenous dose, surgical patients displayed a clearance of 27-75L/h, hepatically impaired patients displayed a clearance of 3-80L/h, and renally impaired patients displayed a clearance of 30-78L/h.[L922]
|
Organic compounds
|
Organoheterocyclic compounds
|
Piperidines
|
Fentanyls
|
[
"approved",
"illicit",
"investigational",
"vet_approved"
] |
[
"N01AH",
"N01A",
"N01",
"N",
"N02AB",
"N02A",
"N02",
"N",
"N01AH",
"N01A",
"N01",
"N"
] |
[
"Humans and other mammals"
] |
[
{
"cost": "1.0",
"description": "Fentanyl-ns 50 mcg/ml syringe",
"unit": "ml"
},
{
"cost": "1.44",
"description": "Fentanyl cit 1500 mcg/30 ml",
"unit": "ml"
},
{
"cost": "1.96",
"description": "Fentanyl 0.05 mg/ml vial",
"unit": "ml"
},
{
"cost": "13.8",
"description": "Fentanyl 12 mcg/hr patch",
"unit": "patch"
},
{
"cost": "16.67",
"description": "Fentanyl 25 mcg/hr patch",
"unit": "patch"
},
{
"cost": "18.21",
"description": "Duragesic 12 mcg/hr patch",
"unit": "patch"
},
{
"cost": "18.64",
"description": "Fentora 100 mcg buccal tablet",
"unit": "tablet"
},
{
"cost": "20.0",
"description": "FentaNYL Citrate 400 mcg Lollipop",
"unit": "lollipop"
},
{
"cost": "21.98",
"description": "Duragesic 25 mcg/hr patch",
"unit": "patch"
},
{
"cost": "23.57",
"description": "Fentora 200 mcg buccal tablet",
"unit": "tablet"
},
{
"cost": "28.84",
"description": "Fentora 300 mcg buccal tablet",
"unit": "tablet"
},
{
"cost": "30.0",
"description": "FentaNYL Citrate 1200 mcg Lollipop",
"unit": "lollipop"
},
{
"cost": "30.47",
"description": "Fentanyl 50 mcg/hr patch",
"unit": "patch"
},
{
"cost": "34.24",
"description": "Fentora 400 mcg buccal tablet",
"unit": "tablet"
},
{
"cost": "38.53",
"description": "FentaNYL Citrate 1600 mcg Lollipop",
"unit": "lollipop"
},
{
"cost": "40.19",
"description": "Duragesic 50 mcg/hr patch",
"unit": "patch"
},
{
"cost": "42.14",
"description": "Actiq 200 mcg Lollipop",
"unit": "lollipop"
},
{
"cost": "46.48",
"description": "Fentanyl 75 mcg/hr patch",
"unit": "patch"
},
{
"cost": "47.37",
"description": "Fentora 600 mcg buccal tablet",
"unit": "tablet"
},
{
"cost": "51.05",
"description": "Actiq 200 mcg lozenge",
"unit": "lozenge"
},
{
"cost": "53.75",
"description": "Actiq 400 mcg Lollipop",
"unit": "lollipop"
},
{
"cost": "54.77",
"description": "Fentora 800 mcg buccal tablet",
"unit": "tablet"
},
{
"cost": "61.3",
"description": "Duragesic 75 mcg/hr patch",
"unit": "patch"
},
{
"cost": "61.69",
"description": "Fentanyl 100 mcg/hr patch",
"unit": "patch"
},
{
"cost": "64.62",
"description": "Actiq 400 mcg lozenge",
"unit": "lozenge"
},
{
"cost": "65.13",
"description": "Actiq 600 mcg Lollipop",
"unit": "lollipop"
},
{
"cost": "66.66",
"description": "Fentanyl 5 25 mcg/hr Patches Box",
"unit": "box"
},
{
"cost": "67.99",
"description": "Fentanyl 5 12 (12.5)mcg/hr Patches Box",
"unit": "box"
},
{
"cost": "75.98",
"description": "Actiq 800 mcg Lollipop",
"unit": "lollipop"
},
{
"cost": "79.16",
"description": "Actiq 600 mcg lozenge",
"unit": "lozenge"
},
{
"cost": "81.36",
"description": "Duragesic 100 mcg/hr patch",
"unit": "patch"
},
{
"cost": "85.7",
"description": "Actiq 1200 mcg Lollipop",
"unit": "lollipop"
},
{
"cost": "93.76",
"description": "Actiq 800 mcg lozenge",
"unit": "lozenge"
},
{
"cost": "95.99",
"description": "Duragesic-12 5 12 mcg/hr Patches Box",
"unit": "box"
},
{
"cost": "114.42",
"description": "Duragesic-25 5 25 mcg/hr Patches Box",
"unit": "box"
},
{
"cost": "119.42",
"description": "Actiq 1600 mcg Lollipop",
"unit": "lollipop"
},
{
"cost": "121.82",
"description": "Actiq 1200 mcg lozenge",
"unit": "lozenge"
},
{
"cost": "129.99",
"description": "Fentanyl 5 50 mcg/hr Patches Box",
"unit": "box"
},
{
"cost": "150.29",
"description": "Actiq 1600 mcg lozenge",
"unit": "lozenge"
},
{
"cost": "205.78",
"description": "Duragesic-50 5 50 mcg/hr Patches Box",
"unit": "box"
},
{
"cost": "210.0",
"description": "Fentanyl 5 100 mcg/hr Patches Box",
"unit": "box"
},
{
"cost": "318.93",
"description": "Duragesic-75 5 75 mcg/hr Patches Box",
"unit": "box"
},
{
"cost": "411.59",
"description": "Duragesic-100 5 100 mcg/hr Patches Box",
"unit": "box"
},
{
"cost": "1062.5",
"description": "Fentanyl citrate powder",
"unit": "g"
},
{
"cost": "1498.18",
"description": "Fentanyl base powder",
"unit": "g"
},
{
"cost": "0.21",
"description": "Fentanyl 0.05 mg/ml ampul",
"unit": "ml"
},
{
"cost": "0.23",
"description": "Sublimaze 0.05 mg/ml ampul",
"unit": "ml"
},
{
"cost": "0.31",
"description": "Fentanyl-ns 500 mcg/50 ml syr",
"unit": "ml"
},
{
"cost": "0.35",
"description": "Fentanyl cit 2750 mcg/55 ml",
"unit": "ml"
},
{
"cost": "0.64",
"description": "Fentanyl-ns 10 mcg/ml syringe",
"unit": "ml"
},
{
"cost": "0.72",
"description": "Fentanyl-ns 20 mcg/ml syringe",
"unit": "ml"
},
{
"cost": "0.99",
"description": "Fentanyl-ns 300 mcg/30 ml syr",
"unit": "ml"
}
] |
[
{
"approved": "2001-11-13",
"country": "United States",
"expires": "2012-06-02",
"number": "6317629"
},
{
"approved": "2001-03-13",
"country": "United States",
"expires": "2019-03-26",
"number": "6200604"
},
{
"approved": "2005-12-13",
"country": "United States",
"expires": "2019-03-26",
"number": "6974590"
},
{
"approved": "2014-05-20",
"country": "United States",
"expires": "2019-03-26",
"number": "8728441"
},
{
"approved": "2014-06-17",
"country": "United States",
"expires": "2019-03-26",
"number": "8753611"
},
{
"approved": "2014-07-01",
"country": "United States",
"expires": "2019-03-26",
"number": "8765100"
},
{
"approved": "2011-01-04",
"country": "United States",
"expires": "2028-06-15",
"number": "7862833"
},
{
"approved": "2012-02-21",
"country": "United States",
"expires": "2024-12-30",
"number": "8119158"
},
{
"approved": "2012-01-10",
"country": "United States",
"expires": "2024-12-30",
"number": "8092832"
},
{
"approved": "2011-01-04",
"country": "United States",
"expires": "2028-06-15",
"number": "7862832"
},
{
"approved": "2004-07-13",
"country": "United States",
"expires": "2019-09-24",
"number": "6761910"
},
{
"approved": "2001-02-27",
"country": "United States",
"expires": "2019-01-28",
"number": "6195582"
},
{
"approved": "2005-04-19",
"country": "United States",
"expires": "2022-04-19",
"number": "6881208"
},
{
"approved": "2013-04-23",
"country": "United States",
"expires": "2032-06-11",
"number": "8428709"
},
{
"approved": "2013-04-23",
"country": "United States",
"expires": "2032-05-21",
"number": "8428708"
},
{
"approved": "2001-01-02",
"country": "United States",
"expires": "2018-01-02",
"number": "6169920"
},
{
"approved": "2014-07-15",
"country": "United States",
"expires": "2032-03-31",
"number": "8781571"
},
{
"approved": "2001-01-30",
"country": "United States",
"expires": "2019-11-02",
"number": "6181963"
},
{
"approved": "1998-12-01",
"country": "United States",
"expires": "2015-12-01",
"number": "5843014"
},
{
"approved": "1997-12-16",
"country": "United States",
"expires": "2016-12-16",
"number": "5697896"
},
{
"approved": "2005-12-13",
"country": "United States",
"expires": "2024-04-01",
"number": "6975902"
},
{
"approved": "2012-10-30",
"country": "United States",
"expires": "2031-09-30",
"number": "8301238"
},
{
"approved": "2015-08-04",
"country": "United States",
"expires": "2033-02-03",
"number": "9095706"
},
{
"approved": "2009-08-25",
"country": "United States",
"expires": "2020-01-22",
"number": "7579019"
},
{
"approved": "2000-12-12",
"country": "United States",
"expires": "2016-10-18",
"number": "6159498"
},
{
"approved": "2004-07-06",
"country": "United States",
"expires": "2019-09-24",
"number": "6759059"
},
{
"approved": "2011-03-22",
"country": "United States",
"expires": "2019-09-24",
"number": "7910132"
},
{
"approved": "2014-11-18",
"country": "United States",
"expires": "2024-01-16",
"number": "8889176"
},
{
"approved": "2002-08-13",
"country": "United States",
"expires": "2018-04-20",
"number": "6432440"
},
{
"approved": "2012-07-10",
"country": "United States",
"expires": "2024-10-03",
"number": "8216604"
},
{
"approved": "2015-07-14",
"country": "United States",
"expires": "2024-01-08",
"number": "9078814"
},
{
"approved": "2013-07-16",
"country": "United States",
"expires": "2030-04-27",
"number": "8486973"
},
{
"approved": "2014-09-16",
"country": "United States",
"expires": "2027-01-25",
"number": "8835460"
},
{
"approved": "2014-09-16",
"country": "United States",
"expires": "2027-01-25",
"number": "8835459"
},
{
"approved": "2016-01-26",
"country": "United States",
"expires": "2027-01-25",
"number": "9241935"
},
{
"approved": "2013-07-16",
"country": "United States",
"expires": "2030-04-27",
"number": "8486972"
},
{
"approved": "2016-06-14",
"country": "United States",
"expires": "2031-09-30",
"number": "9364656"
},
{
"approved": "2017-03-21",
"country": "United States",
"expires": "2027-07-23",
"number": "9597288"
},
{
"approved": "2017-05-09",
"country": "United States",
"expires": "2027-01-25",
"number": "9642844"
},
{
"approved": "2016-03-22",
"country": "United States",
"expires": "2027-01-25",
"number": "9289387"
},
{
"approved": "2017-05-09",
"country": "United States",
"expires": "2027-01-25",
"number": "9642797"
},
{
"approved": "2017-08-15",
"country": "United States",
"expires": "2032-01-26",
"number": "9731869"
},
{
"approved": "2017-08-15",
"country": "United States",
"expires": "2031-10-17",
"number": "9731121"
},
{
"approved": "2017-11-14",
"country": "United States",
"expires": "2024-01-08",
"number": "9814705"
},
{
"approved": "2018-07-10",
"country": "United States",
"expires": "2027-01-25",
"number": "10016403"
},
{
"approved": "2020-04-07",
"country": "United States",
"expires": "2027-01-25",
"number": "10610523"
}
] |
1-Phenethyl-4-(N-phenylpropionamido)piperidine | 1-phenethyl-4-N-propionylanilinopiperidine | Fentanil | Fentanila | Fentanilo | Fentanyl | Fentanyl CII | Fentanylum | N-(1-phenethyl-4-piperidinyl)-N-phenylpropionamide | N-(1-phenethyl-4-piperidyl)propionanilide | N-(1-Phenethyl-piperidin-4-yl)-N-phenyl-propionamide | N-(1-phenethylpiperidin-4-yl)-N-phenylpropionamide | N-phenethyl-4-(N-propionylanilino)piperidine | N-phenyl-N-(1-(2-phenylethyl)-4-piperidinyl)propanamide | Phentanyl | hMOP | M-OR-1 | MOP | MOR-1 | MOR1 | Mu opiate receptor | Mu opioid receptor | D-OR-1 | DOR-1 | OPRD | K-OR-1 | KOR-1 | OPRK | ATP-binding cassette sub-family B member 1 | MDR1 | Multidrug resistance protein 1 | P-glycoprotein 1 | PGY1 | Phospholipid transporter ABCB1 | 1,4-cineole 2-exo-monooxygenase | 1,8-cineole 2-exo-monooxygenase | 1.14.14.1 | Albendazole monooxygenase (sulfoxide-forming) | Albendazole sulfoxidase | Cholesterol 25-hydroxylase | CYP3A3 | CYPIIIA3 | CYPIIIA4 | Cytochrome P450 3A3 | Cytochrome P450 HLp | Cytochrome P450 NF-25 | Cytochrome P450-PCN1 | Nifedipine oxidase | Quinine 3-monooxygenase | 1.14.14.1 | CYPIIIA7 | Cytochrome P450-HFLA | P450HLp2 | AGP 1 | AGP1 | OMD 1 | Orosomucoid-1 | AGP 2 | AGP2 | OMD 2 | Orosomucoid-2 | ATP-binding cassette sub-family B member 1 | MDR1 | Multidrug resistance protein 1 | P-glycoprotein 1 | PGY1 | Phospholipid transporter ABCB1
|
[
"Abstral",
"Abstral",
"Abstral",
"Abstral",
"Abstral",
"Abstral",
"Abstral",
"Abstral",
"Abstral",
"Abstral",
"Abstral",
"Abstral",
"Abstral",
"Abstral",
"Abstral",
"Abstral",
"Abstral",
"Abstral",
"Abstral fentanyl",
"Abstral fentanyl",
"Abstral fentanyl",
"Abstral fentanyl",
"Abstral fentanyl",
"Abstral fentanyl",
"Actiq",
"Actiq",
"Actiq",
"Actiq",
"Actiq",
"Actiq",
"Apo-fentanyl Matrix",
"Apo-fentanyl Matrix",
"Apo-fentanyl Matrix",
"Apo-fentanyl Matrix",
"Apo-fentanyl Matrix",
"Co Fentanyl",
"Co Fentanyl",
"Co Fentanyl",
"Co Fentanyl",
"Co Fentanyl",
"Co Fentanyl",
"Duragesic",
"Duragesic",
"Duragesic",
"Duragesic",
"Duragesic",
"Duragesic",
"Duragesic",
"Duragesic",
"Duragesic",
"Duragesic",
"Duragesic",
"Duragesic",
"Duragesic",
"Duragesic",
"Duragesic",
"Duragesic",
"Duragesic",
"Duragesic",
"Duragesic",
"DURAGESIC (fentanyl system)",
"DURAGESIC (fentanyl system)",
"DURAGESIC (fentanyl system)",
"DURAGESIC (fentanyl system)",
"DURAGESIC (fentanyl system)",
"Duragesic 100",
"Duragesic 12",
"Duragesic 25",
"Duragesic 50",
"Duragesic 75",
"Effentora",
"Effentora",
"Effentora",
"Effentora",
"Effentora",
"Effentora",
"Effentora",
"Effentora",
"Effentora",
"Effentora",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl",
"Fentanyl - NOVAPLUS",
"Fentanyl - NOVAPLUS",
"Fentanyl - NOVAPLUS",
"Fentanyl - NOVAPLUS",
"Fentanyl Buccal",
"Fentanyl Buccal",
"Fentanyl Buccal",
"Fentanyl Buccal",
"Fentanyl Buccal",
"Fentanyl Buccal",
"Fentanyl Buccal",
"Fentanyl Buccal",
"Fentanyl Buccal",
"Fentanyl Buccal",
"Fentanyl Citrate",
"Fentanyl Citrate",
"Fentanyl Citrate",
"Fentanyl Citrate",
"Fentanyl Citrate",
"Fentanyl Citrate",
"Fentanyl Citrate",
"Fentanyl Citrate",
"Fentanyl Citrate",
"Fentanyl Citrate",
"Fentanyl Citrate",
"Fentanyl Citrate",
"Fentanyl Citrate",
"Fentanyl Citrate",
"Fentanyl Citrate",
"Fentanyl Citrate",
"Fentanyl Citrate",
"Fentanyl Citrate",
"Fentanyl Citrate",
"Fentanyl Citrate",
"Fentanyl Citrate",
"Fentanyl Citrate",
"Fentanyl Citrate",
"Fentanyl Citrate",
"Fentanyl Citrate",
"Fentanyl Citrate",
"Fentanyl Citrate",
"Fentanyl Citrate",
"Fentanyl Citrate",
"Fentanyl Citrate",
"Fentanyl Citrate",
"Fentanyl Citrate",
"Fentanyl Citrate",
"Fentanyl Citrate",
"Fentanyl Citrate",
"Fentanyl Citrate",
"Fentanyl Citrate",
"Fentanyl Citrate",
"Fentanyl Citrate",
"Fentanyl Citrate",
"Fentanyl Citrate",
"Fentanyl Citrate",
"Fentanyl Citrate",
"Fentanyl Citrate",
"Fentanyl Citrate",
"Fentanyl Citrate",
"Fentanyl Citrate",
"Fentanyl Citrate",
"Fentanyl Citrate",
"Fentanyl Citrate",
"Fentanyl Citrate",
"Fentanyl Citrate",
"Fentanyl Citrate",
"Fentanyl Citrate",
"Fentanyl Citrate",
"Fentanyl Citrate",
"Fentanyl Citrate",
"Fentanyl Citrate",
"Fentanyl Citrate",
"Fentanyl Citrate",
"Fentanyl Citrate",
"Fentanyl Citrate",
"Fentanyl Citrate",
"Fentanyl Citrate",
"Fentanyl Citrate",
"Fentanyl Citrate",
"Fentanyl Citrate",
"Fentanyl Citrate",
"Fentanyl Citrate",
"Fentanyl Citrate",
"Fentanyl Citrate",
"Fentanyl Citrate",
"Fentanyl Citrate",
"Fentanyl Citrate",
"Fentanyl Citrate Injection",
"Fentanyl Citrate Injection Sdz",
"Fentanyl Citrate Injection U.S.P.-liq IV Im Epd",
"Fentanyl Citrate Injection USP",
"Fentanyl Citrate Injection USP",
"Fentanyl Citrate Injection USP",
"Fentanyl Citrate Injection USP 50mcg/ml",
"Fentanyl Citrate Injection, USP",
"Fentanyl Citrate, Bupivacaine HCl",
"Fentanyl Citrate, Bupivacaine HCl",
"Fentanyl Citrate, Bupivacaine HCl",
"Fentanyl Citrate, Bupivacaine HCl",
"Fentanyl Injection BP",
"Fentanyl Injection BP",
"Fentanyl Injection BP",
"Fentanyl Injection BP",
"Fentanyl Patch",
"Fentanyl Patch",
"Fentanyl Patch",
"Fentanyl Patch",
"Fentanyl Patch",
"Fentanyl system",
"Fentanyl system",
"Fentanyl system",
"Fentanyl system",
"Fentanyl system",
"Fentanyl System",
"Fentanyl System",
"Fentanyl System",
"Fentanyl Transdermal",
"Fentanyl Transdermal",
"Fentanyl Transdermal",
"Fentanyl Transdermal",
"Fentanyl Transdermal",
"Fentanyl Transdermal",
"Fentanyl Transdermal",
"Fentanyl Transdermal",
"Fentanyl Transdermal",
"Fentanyl Transdermal",
"Fentanyl Transdermal",
"Fentanyl Transdermal",
"Fentanyl Transdermal",
"Fentanyl Transdermal",
"Fentanyl Transdermal",
"Fentanyl Transdermal System",
"Fentanyl Transdermal System",
"Fentanyl transdermal system",
"Fentanyl transdermal system",
"Fentanyl transdermal system",
"Fentanyl transdermal system",
"Fentanyl transdermal system",
"Fentanyl Transdermal System",
"Fentanyl Transdermal System",
"FENTANYL TRANSDERMAL system",
"Fentanyl Transdermal System",
"Fentanyl Transdermal System",
"Fentanyl Transdermal System 100",
"Fentanyl Transdermal System 25",
"Fentanyl Transdermal System 50",
"Fentanyl Transdermal System 75",
"Fentora",
"Fentora",
"Fentora",
"Fentora",
"Fentora",
"Fentora",
"Fentora",
"Fentora",
"Fentora",
"Fentora",
"Fentora",
"Innovar Inj",
"Instanyl",
"Instanyl",
"Instanyl",
"Instanyl",
"Instanyl",
"Instanyl",
"Instanyl",
"Instanyl",
"Instanyl",
"Instanyl",
"Instanyl",
"Instanyl",
"Instanyl",
"Instanyl",
"Instanyl",
"Instanyl",
"Instanyl",
"Instanyl",
"Instanyl",
"Instanyl",
"Instanyl",
"Instanyl",
"Instanyl",
"Instanyl",
"Instanyl",
"Instanyl",
"Instanyl",
"Instanyl",
"Instanyl",
"Instanyl",
"Instanyl",
"Instanyl",
"Instanyl",
"Instanyl",
"Instanyl",
"Instanyl",
"Instanyl",
"Ionsys",
"Ionsys",
"Ionsys",
"Ionsys",
"Lazanda",
"Lazanda",
"Lazanda",
"Lazanda",
"Lazanda",
"Lazanda",
"Lazanda",
"Lazanda",
"Mylan-fentanyl Matrix Patch",
"Mylan-fentanyl Matrix Patch",
"Mylan-fentanyl Matrix Patch",
"Mylan-fentanyl Matrix Patch",
"Mylan-fentanyl Matrix Patch",
"Onsolis",
"Onsolis",
"Onsolis",
"Onsolis",
"Onsolis",
"Onsolis",
"Onsolis",
"Onsolis",
"Onsolis",
"Onsolis",
"Pat-fentanyl Mat",
"Pat-fentanyl Mat",
"Pat-fentanyl Mat",
"Pat-fentanyl Mat",
"Pat-fentanyl Mat",
"Pecfent",
"Pecfent",
"Pecfent",
"Pecfent",
"Pecfent",
"Pecfent",
"Pecfent",
"PMS-fentanyl Mtx",
"PMS-fentanyl Mtx",
"PMS-fentanyl Mtx",
"PMS-fentanyl Mtx",
"PMS-fentanyl Mtx",
"Ran-fentanyl Matrix Patch",
"Ran-fentanyl Matrix Patch",
"Ran-fentanyl Matrix Patch",
"Ran-fentanyl Matrix Patch",
"Ran-fentanyl Matrix Patch",
"Ran-fentanyl Transdermal System",
"Ran-fentanyl Transdermal System",
"Ran-fentanyl Transdermal System",
"Ran-fentanyl Transdermal System",
"Sandoz Fentanyl Patch",
"Sandoz Fentanyl Patch",
"Sandoz Fentanyl Patch",
"Sandoz Fentanyl Patch",
"Sandoz Fentanyl Patch",
"Sandoz Fentanyl Patch",
"Sublimaze",
"Sublimaze Inj 50mcg/ml",
"Subsys",
"Subsys",
"Subsys",
"Subsys",
"Subsys",
"Subsys",
"Subsys",
"Subsys",
"Subsys",
"Subsys",
"Subsys",
"Subsys",
"Subsys",
"Subsys",
"Teva-fentanyl",
"Teva-fentanyl",
"Teva-fentanyl",
"Teva-fentanyl",
"Teva-fentanyl",
"Transmucosal Fentanyl Citrate",
"Transmucosal Fentanyl Citrate",
"Transmucosal Fentanyl Citrate"
] |
[
"Durogesic",
"Fentanest",
"Nasalfent",
"Rapinyl"
] |
[
"Fentanyl Citrate, Bupivacaine HCl",
"Fentanyl Citrate, Bupivacaine HCl",
"Fentanyl Citrate, Bupivacaine HCl",
"Fentanyl Citrate, Bupivacaine HCl",
"Innovar Inj"
] |
[
"P35372",
"P41143",
"P41145",
"P08183"
] |
[
"P08684",
"P24462"
] |
[
"P02768",
"P02763",
"P19652"
] |
[
"P08183"
] |
DB00708
|
Sufentanil
|
Sufentanil is an opioid analgesic that is used as an adjunct in anesthesia, in balanced anesthesia, and as a primary anesthetic agent. It is administered by the intravenous, epidural and sublingual routes.
Also known as _Dsuvia_, the sublingual form is used for the management of acute pain in adults that is severe to warrant the use of an opioid analgesic in certified medically supervised healthcare settings, including hospitals, surgical centers, and emergency departments [L4717]. Consideration may be made in the future for the use of the sublingual form in the US military in cases where analgesia is required immediately [L4718].
The sublingual form, manufactured by AcelRx Pharmaceuticals, Inc. (AcelRx), was approved on November 2, 2018 [L4717].
This route of administration is intended to be a simple, effective, non-invasive analgesic option to enable healthcare professionals to rapidly manage acute pain without difficult intravenous or epidural administration [L4717], [A39633].
|
solid
|
The indications for this drug are as follows:
1. As an analgesic adjunct in the maintenance of balanced general anesthesia in patients who are intubated and ventilated.
2. As a primary anesthetic agent for the induction and maintenance of anesthesia with 100% oxygen in patients undergoing major surgical procedures, in patients who are intubated and ventilated, such as cardiovascular surgery or neurosurgical procedures in the sitting position, to provide favorable myocardial and cerebral oxygen balance or when extended postoperative ventilation is anticipated.
3. For epidural administration as an analgesic combined with low dose (usually 12.5 mg per administration) bupivacaine usually during labor and vaginal delivery
4. The sublingual form is indicated for the management of acute pain in adults that is severe to warrant the use of an opioid analgesic in certified medically supervised healthcare settings, including hospitals, surgical centers, and emergency departments.
[FDA label]
|
**Effect on the Central Nervous System (CNS)**
In clinical settings, sufentanil exerts its principal pharmacologic effects on the central nervous system. Its primary therapeutic actions are analgesia and sedation. Sufentanil may increase pain tolerance and decrease the perception of pain. This drug depresses the respiratory centers, depresses the cough reflex, and constricts the pupils [F2009], [A39637]. When used in balanced general anesthesia, sufentanil has been reported to be as much as 10 times as potent as fentanyl. When administered intravenously as a primary anesthetic agent with 100% oxygen, sufentanil is approximately 5 to 7 times as potent as fentanyl [FDA label]. High doses of intravenous sufentanil have been shown to cause muscle rigidity, likely as a result of an effect on the substantia nigra and the striate nucleus in the brain. Sleep-inducing (hypnotic) activity can be demonstrated by EEG alterations [FDA label].
**Effects on the Respiratory System**
Sufentanil may cause respiratory depression [FDA label].
**Effects on the Cardiovascular System**
Sufentanil causes peripheral vasodilation which may result in orthostatic hypotension or syncope. Bradycardia may also occur [F2009]. Clinical signs or symptoms of histamine release and/or peripheral vasodilation may include pruritus, flushing, red eyes and sweating and/or orthostatic hypotension [FDA label].
**Effects on the Gastrointestinal Tract**
Sufentanil causes a reduction in motility associated with an increase in smooth muscle tone in both the antrum of the stomach and duodenum. Digestion of food in the small intestine may be delayed and propulsive contractions are decreased. Propulsive peristaltic waves in the colon are decreased, while tone may be increased and lead to spasm, resulting in constipation. Other opioid-induced effects may include a reduction in biliary and pancreatic secretions, spasm of the sphincter of Oddi, as well as temporary elevations in serum amylase [FDA label].
|
Sufentanil is a synthetic, potent opioid with highly selective binding to μ-opioid receptors [F2009]. These receptors are widely distributed in the human brain, spinal cord, and other tissues [A39636], [A39637].
In general, opioids decrease cAMP (affecting neural signaling pathways), decrease neurotransmitter release, and cause membrane hyperpolarization, all of which contribute to the relief of painful symptoms [A39637].
Opiate receptors are coupled with G-protein receptors and function as both positive and negative regulators of synaptic neural transmission via G-proteins that activate effector proteins. Binding of the opiate receptor leads to the exchange of GTP for GDP on the G-protein complex. As the effector system is adenylate cyclase and cAMP, located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase. The release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine, and noradrenaline is then inhibited [A39637].
Opioids close N-type voltage-operated calcium channels (OP2-receptor agonist), also preventing neurotransmitter release [A39637].
Sufentanil and other opioids open calcium-dependent inwardly rectifying potassium channels, resulting in hyperpolarization and reduced neuronal excitability [A39636], [A39637].
|
Bioavailability of a single sublingual tablet was 52%, decreasing to 35% with repeat dosing [A39629].
After epidural administration of incremental doses totaling 5 to 40 mcg sufentanil during labor and delivery, maternal and neonatal sufentanil plasma concentrations were at or near the 0.05 to 0.1 ng/mL limit of detection, and were slightly higher in mothers than in their infants [FDA label].
|
The liver and small intestine are the major sites of biotransformation [FDA label].
Sufentanil is rapidly metabolized to a number of inactive metabolites, with oxidative N- and O-dealkylation being the major routes of elimination [F2009].
|
**LD<sub>50</sub>:** 18.7 mg/kg (IV in mice) [MSDS]
**A Note on Respiratory Depression**
Major, life-threatening, or fatal respiratory depression has been reported with the use of opioids, even in cases where it is used as recommended. Respiratory depression may lead to respiratory arrest and death if not diagnosed and treated appropriately. This drug should be administered only by persons specifically trained in the use of anesthetic drugs and the management of the respiratory effects of potent opioids, including respiration and cardiac resuscitation of patients in the age group being treated. This training must include the establishment and maintenance of a patent airway and assisted ventilation [FDA label].
**Carcinogenesis**
Long-term studies in animals to evaluate the carcinogenic potential of sufentanil have not been conducted [FDA label].
**Mutagenesis**
Sufentanil was not found to be genotoxic in the in vitro bacterial reverse mutation assay (Ames assay) or in the in vivo rat bone marrow micronucleous assay [FDA label].
**Reproductive Toxicity**
Sufentanil caused embryolethality in rats and rabbits treated for 10-30 days during pregnancy with 2.5 times the maximum human dose by intravenous administration. The embryolethal effect was thought to be secondary to the toxicity for the mother animal model. No negative effects were noted in another study in rats that were treated with 20 times the maximum human dose in the period of organogenesis. The preclinical effects were only seen following administrations of levels significantly above the maximum human dose, which is therefore of minimal relevance for clinical use [F2009].
**Pregnancy**
May cause fetal harm [FDA label]
**The Use in Lactation**
Infants exposed to this drug through breast milk should be monitored for excess sedation and respiratory depression [FDA label].
|
The elimination half-life is 164 minutes in adults when administered intravenously (IV). The elimination half-life of sufentanil is shorter (e.g. 97 +/- 42 minutes) in infants and children, and longer in neonates (e.g. 434 +/- 160 minutes) compared to that of adolescents and adults [FDA label].
After a single administration of a 15 microgram sufentanil sublingual tablet, mean terminal phase half-lives in the range of 6-10 hours have been observed. After multiple administrations, a longer average terminal half-life of up to 18 hours was measured, owing to the higher plasma concentrations of sufentanil achieved after repeated dosing and due to the possibility to quantify these concentrations over a longer time period [F2009].
|
Plasma protein binding of sufentanil, related to the alpha acid glycoprotein concentration, was approximately 93% in healthy males, 91% in mothers and 79% in neonates [FDA label].
|
Approximately 80% of the administered dose is excreted within 24 hours and only 2% of the dose is eliminated as unchanged drug [FDA label].
|
Sufentanil has a distribution time of 1.4 minutes and redistribution time of 17.1 minutes [FDA label].
The central volume of distribution after intravenous application of sufentanil is approximately 14 L and the volume of distribution at steady state is approximately 350 L [F2009].
|
The total plasma clearance after single intravenous administration is about 917 l/min [F2009].
The clearance of sufentanil in healthy neonates is approximately one-half that in adults and children. The clearance rate of sufentanil can be further reduced by up to a third in neonates with cardiovascular disease [FDA label].
|
Organic compounds
|
Benzenoids
|
Benzene and substituted derivatives
|
Anilides
|
[
"approved",
"investigational"
] |
[
"N01AH",
"N01A",
"N01",
"N"
] |
[
"Humans and other mammals"
] |
[
{
"cost": "3.92",
"description": "Sufentanil 50 mcg/ml ampul",
"unit": "ml"
},
{
"cost": "5.38",
"description": "Sufenta 50 mcg/ml ampul",
"unit": "ml"
},
{
"cost": "18927.0",
"description": "Sufentanil citrate powder",
"unit": "g"
}
] |
[
{
"approved": "2014-07-15",
"country": "United States",
"expires": "2027-01-05",
"number": "8778393"
},
{
"approved": "2014-07-15",
"country": "United States",
"expires": "2027-01-05",
"number": "8778394"
},
{
"approved": "2013-09-17",
"country": "United States",
"expires": "2027-01-05",
"number": "8535714"
},
{
"approved": "2016-04-26",
"country": "United States",
"expires": "2027-01-05",
"number": "9320710"
},
{
"approved": "2012-06-19",
"country": "United States",
"expires": "2030-10-22",
"number": "8202535"
},
{
"approved": "2012-07-24",
"country": "United States",
"expires": "2027-01-05",
"number": "8226978"
},
{
"approved": "2014-10-21",
"country": "United States",
"expires": "2030-10-22",
"number": "8865743"
},
{
"approved": "2014-10-21",
"country": "United States",
"expires": "2027-01-05",
"number": "8865211"
},
{
"approved": "2013-11-05",
"country": "United States",
"expires": "2030-03-16",
"number": "8574189"
},
{
"approved": "2012-07-31",
"country": "United States",
"expires": "2027-01-05",
"number": "8231900"
},
{
"approved": "2012-08-28",
"country": "United States",
"expires": "2027-01-05",
"number": "8252328"
},
{
"approved": "2017-08-29",
"country": "United States",
"expires": "2027-01-05",
"number": "9744129"
},
{
"approved": "2015-02-03",
"country": "United States",
"expires": "2031-07-29",
"number": "8945592"
},
{
"approved": "2012-08-28",
"country": "United States",
"expires": "2027-01-05",
"number": "8252329"
},
{
"approved": "2019-04-02",
"country": "United States",
"expires": "2027-01-05",
"number": "10245228"
},
{
"approved": "2019-07-09",
"country": "United States",
"expires": "2027-01-05",
"number": "10342762"
},
{
"approved": "2019-12-17",
"country": "United States",
"expires": "2027-01-05",
"number": "10507180"
},
{
"approved": "2021-01-19",
"country": "United States",
"expires": "2030-03-16",
"number": "10896751"
},
{
"approved": "2018-02-02",
"country": "United States",
"expires": "2038-02-02",
"number": "11672738"
},
{
"approved": "2010-03-16",
"country": "United States",
"expires": "2030-03-16",
"number": "11676691"
},
{
"approved": "2010-03-16",
"country": "United States",
"expires": "2030-03-16",
"number": "12033733"
}
] |
N-(4-(Methoxymethyl)-1-(2-(2-thienyl)ethyl)-4-piperidinyl)-N-phenylpropanamide | N-(4-(Methoxymethyl)-1-(2-(2-thienyl)ethyl)-4-piperidyl)propionanilide | Sufentanil | Sufentanilo | Sufentanilum | Sufentanyl | hMOP | M-OR-1 | MOP | MOR-1 | MOR1 | Mu opiate receptor | Mu opioid receptor | D-OR-1 | DOR-1 | OPRD | K-OR-1 | KOR-1 | OPRK | 1,4-cineole 2-exo-monooxygenase | 1,8-cineole 2-exo-monooxygenase | 1.14.14.1 | Albendazole monooxygenase (sulfoxide-forming) | Albendazole sulfoxidase | Cholesterol 25-hydroxylase | CYP3A3 | CYPIIIA3 | CYPIIIA4 | Cytochrome P450 3A3 | Cytochrome P450 HLp | Cytochrome P450 NF-25 | Cytochrome P450-PCN1 | Nifedipine oxidase | Quinine 3-monooxygenase
|
[
"Dsuvia",
"Dzuveo",
"Dzuveo",
"Sufenta",
"Sufenta Inj 50mcg/ml",
"Sufenta Inj 50mcg/ml",
"Sufentanil Citrate",
"Sufentanil Citrate",
"Sufentanil Citrate",
"Sufentanil Citrate",
"Sufentanil Citrate",
"Sufentanil Citrate",
"Sufentanil Citrate",
"Sufentanil Citrate Injection",
"Sufentanil Citrate Injection USP",
"Sufentanil Citrate Injection USP",
"Zalviso",
"Zalviso",
"Zalviso",
"Zalviso",
"Zalviso",
"Zalviso"
] |
[
"Chronogesic",
"Disufen",
"Fastfen",
"Sufenta Forte",
"Sufenta mite",
"Sufentil",
"Zuftil"
] |
[] |
[
"P35372",
"P41143",
"P41145"
] |
[
"P08684"
] |
[] |
[] |
DB01433
|
Methadyl acetate
|
A narcotic analgesic with a long onset and duration of action. It is used mainly in the treatment of narcotic dependence.
|
solid
|
Used mainly in the treatment of narcotic dependence.
|
Methadyl Acetate is a narcotic analgesic with a long onset and duration of action. The drug decreases a patients opioid use by preventing opioid withdrawal and in how it can mimic some of the effects of opioids.
|
Methadyl Acetate is primarily a mu-type opioid receptor agonist. It functions similarily to methadone.
| null | null | null | null | null | null | null | null |
Organic compounds
|
Benzenoids
|
Benzene and substituted derivatives
|
Diphenylmethanes
|
[
"experimental",
"illicit"
] |
[] |
[
"Humans and other mammals"
] |
[] |
[] |
Acetilmetadol | Acetylmethadol | Acetylmethadolum | Methadyl acetate | hMOP | M-OR-1 | MOP | MOR-1 | MOR1 | Mu opiate receptor | Mu opioid receptor
|
[] |
[] |
[] |
[
"P35372"
] |
[] |
[] |
[] |
DB01444
|
Dimethylthiambutene
|
Dimethylthiambutene (N,N-Dimethyl-1-methyl-3,3-di-2-thienylallylamine, Dimethibutin, Ohton) is an opioid analgesic drug. It is now under international control under Schedule I of the UN Single Convention On Narcotic Drugs 1961, presumably due to high abuse potential, although little more information is available.
|
liquid
|
Dimethylthiambutene is an opioid analgesic previously used in moderate pain relief.
| null | null | null | null | null | null | null | null | null | null |
Organic compounds
|
Organoheterocyclic compounds
|
Heteroaromatic compounds
| null |
[
"experimental",
"illicit"
] |
[] |
[
"Humans and other mammals"
] |
[] |
[] |
3-dimethylamino-1,1-bis(2-thienyl)-1-butene | 3-dimethylamino-1,1-di-(2'-thienyl)-1-butene | Dimethibutin | Dimethylthiambutene | Dimethylthiambutenum | Dimetiltiambutene | Dimetiltiambuteno | N,N-dimethyl-4,4-di(2-thienyl)-3-buten-2-amine | N,N,1-trimethyl-3,3-di-2-thienylallylamine | N,N,1-trimethyl-3,3-di(2-thienyl)-2-propenylamine | Ohton | hMOP | M-OR-1 | MOP | MOR-1 | MOR1 | Mu opiate receptor | Mu opioid receptor | D-OR-1 | DOR-1 | OPRD
|
[] |
[] |
[] |
[
"P35372",
"P41143"
] |
[] |
[] |
[] |
DB01565
|
Dihydromorphine
|
A semisynthetic analgesic used in the study of narcotic receptors. It has abuse potential. [PubChem]
|
solid
|
Dihydromorphine is an opioid analgesic used for moderate to severe pain relief.
| null | null | null | null | null | null | null | null | null | null |
Organic compounds
|
Alkaloids and derivatives
|
Morphinans
| null |
[
"experimental",
"illicit"
] |
[] |
[] |
[] |
[] |
Dihydromorphine | hMOP | M-OR-1 | MOP | MOR-1 | MOR1 | Mu opiate receptor | Mu opioid receptor | K-OR-1 | KOR-1 | OPRK | D-OR-1 | DOR-1 | OPRD | 2.3.2.27 | B-cell chronic lymphocytic leukemia tumor suppressor Leu5 | LEU5 | Leukemia-associated protein 5 | Putative tumor suppressor RFP2 | Ret finger protein 2 | RFP2 | RING finger protein 77 | RING-type E3 ubiquitin transferase TRIM13 | RNF77 | Tripartite motif-containing protein 13 | Corticotropin-lipotropin | POMC
|
[] |
[] |
[] |
[
"P35372",
"P41145",
"P41143",
"O60858",
"P01189"
] |
[] |
[] |
[] |
DB06738
|
Ketobemidone
|
Ketobemidone is a powerful opioid analgesic. It also has some NMDA-antagonist properties. This makes it useful for some types of pain that don't respond well to other opioids. The most commonly cited equalisation ratio for analgesic doses is 25 mg of ketobemidone hydrobromide to 60 mg of morphine hydrochloride or sulfate and circa 8 mg of ketobemidone by injection.
|
solid
|
For the treatment of all types of severe pain, such as postoperative, cancer, kidney stones and fractures.
| null |
Ketobemidone (Cliradon, Ketogan, Ketodur, Cymidon, Ketorax, &c.) is a powerful opioid analgesic. It also has some NMDA-antagonist properties. This makes it useful for some types of pain that don't respond well to other opioids. The most commonly cited equalisation ratio for analgesic doses is 25 mg of ketobemidone hydrobromide to 60 mg of morphine hydrochloride or sulfate and circa 8 mg of ketobemidone by injection.
|
34% (oral), 44% (rectal)
|
Ketobemidone is mainly metabolised by conjugation of the phenolic hydroxyl group, and by N-desmethylation. Only about 13-24% is excreted unchanged after iv. administration.
|
Base: Rat Intravenous LD50: 10 mg/kg; Mouse Intravenous LD50: 14 mg/kg.
Hydrochloride salt: Rat Oral LD50: 215 mg/kg; Rat Intravenous LD50: 40 mg/kg
|
Plasma half-life: 2.42 +/- 0.41 h (m +/- SD).
Elimination half-life: 3.27 +/- 0.32 h
| null | null | null | null |
Organic compounds
|
Organoheterocyclic compounds
|
Piperidines
|
Phenylpiperidines
|
[
"investigational"
] |
[
"N02AB",
"N02A",
"N02",
"N",
"N02AG",
"N02A",
"N02",
"N"
] |
[
"Humans and other mammals"
] |
[] |
[] |
Cetobemidona | Cetobemidone | Cetobemidonum | Ketobemidone | hMOP | M-OR-1 | MOP | MOR-1 | MOR1 | Mu opiate receptor | Mu opioid receptor | K-OR-1 | KOR-1 | OPRK | D-OR-1 | DOR-1 | OPRD | GluN1 | Glutamate [NMDA] receptor subunit zeta-1 | hNR1 | N-methyl-D-aspartate receptor subunit NR1 | NMD-R1 | NMDAR1 | GluN2A | Glutamate [NMDA] receptor subunit epsilon-1 | hNR2A | N-methyl D-aspartate receptor subtype 2A | NMDAR2A | NR2A | GluN2B | Glutamate [NMDA] receptor subunit epsilon-2 | hNR3 | N-methyl D-aspartate receptor subtype 2B | N-methyl-D-aspartate receptor subunit 3 | NMDAR2B | NR2B | NR3 | GluN2C | Glutamate [NMDA] receptor subunit epsilon-3 | N-methyl D-aspartate receptor subtype 2C | NMDAR2C | NR2C | EB11 | GluN2D | Glutamate [NMDA] receptor subunit epsilon-4 | N-methyl D-aspartate receptor subtype 2D | NMDAR2D | NR2D | GluN3A | KIAA1973 | N-methyl-D-aspartate receptor subtype 3A | NMDAR-L | NMDAR3A | NR3A | GluN3B | N-methyl-D-aspartate receptor subtype 3B | NMDAR3B | NR3B | 1.14.99.1 | COX-1 | COX1 | Cyclooxygenase-1 | PGH synthase 1 | PGHS-1 | PHS 1 | Prostaglandin H2 synthase 1 | Prostaglandin-endoperoxide synthase 1 | (R)-limonene 6-monooxygenase | (S)-limonene 6-monooxygenase | (S)-limonene 7-monooxygenase | 1.14.14.1 | Cholesterol 25-hydroxylase | CYP2C10 | CYPIIC9 | Cytochrome P-450MP | Cytochrome P450 MP-4 | Cytochrome P450 MP-8 | Cytochrome P450 PB-1 | S-mephenytoin 4-hydroxylase | 1,4-cineole 2-exo-monooxygenase | 1,8-cineole 2-exo-monooxygenase | 1.14.14.1 | Albendazole monooxygenase (sulfoxide-forming) | Albendazole sulfoxidase | Cholesterol 25-hydroxylase | CYP3A3 | CYPIIIA3 | CYPIIIA4 | Cytochrome P450 3A3 | Cytochrome P450 HLp | Cytochrome P450 NF-25 | Cytochrome P450-PCN1 | Nifedipine oxidase | Quinine 3-monooxygenase | 2.4.1.17 | GNT1 | lugP4 | UDP-glucuronosyltransferase 1-9 | UDP-glucuronosyltransferase 1-I | UDPGT 1-9 | UGT-1I | UGT1 | UGT1-09 | UGT1.9 | UGT1*9 | UGT1A9 | UGT1I | 1,4-cineole 2-exo-monooxygenase | 1.14.13.- | CYPIIB6 | Cytochrome P450 IIB1 | (R)-limonene 6-monooxygenase | (S)-limonene 6-monooxygenase | (S)-limonene 7-monooxygenase | 1.14.14.1 | CYPIIC17 | CYPIIC19 | Cytochrome P450-11A | Cytochrome P450-254C | Fenbendazole monooxygenase (4'-hydroxylating) | Mephenytoin 4-hydroxylase | 1.14.14.1 | CYPIIC8 | Cytochrome P450 form 1 | Cytochrome P450 IIC2 | Cytochrome P450 MP-12 | Cytochrome P450 MP-20 | S-mephenytoin 4-hydroxylase
|
[] |
[
"Cliradon",
"Ketogan",
"Ketorax"
] |
[] |
[
"P35372",
"P41145",
"P41143",
"Q05586",
"Q12879",
"Q13224",
"Q14957",
"O15399",
"Q8TCU5",
"O60391"
] |
[
"P23219",
"P11712",
"P08684",
"O60656",
"P20813",
"P33261",
"P10632"
] |
[] |
[] |
DB00892
|
Oxybuprocaine
|
Oxybuprocaine (also known as Benoxinate) is a local anesthetic, which is used especially in ophthalmology and otolaryngology. Oxybuprocaine binds to sodium channels and reversibly stabilizes the neuronal membrane which decreases its permeability to sodium ions.
|
solid
|
Used to temporarily numb the front surface of the eye so that the eye pressure can be measured or a foreign body removed.
|
Oxybuprocaine is a local anaesthetic. It may be less irritating than tetracaine, and the onset and duration of action are similar to tetracaine.
|
Oxybuprocaine binds to sodium channel and reversibly stabilizes the neuronal membrane which decreases its permeability to sodium ions. Depolarization of the neuronal membrane is inhibited thereby blocking the initiation and conduction of nerve impulses.
| null | null | null | null | null | null | null | null |
Organic compounds
|
Benzenoids
|
Benzene and substituted derivatives
|
Benzoic acids and derivatives
|
[
"approved",
"investigational"
] |
[
"S01HA",
"S01H",
"S01",
"S",
"D04AB",
"D04A",
"D04",
"D"
] |
[
"Humans and other mammals"
] |
[
{
"cost": "2.29",
"description": "Fluress eye drops",
"unit": "ml"
}
] |
[
{
"approved": "2019-05-21",
"country": "United States",
"expires": "2037-11-15",
"number": "10293047"
},
{
"approved": "2020-04-28",
"country": "United States",
"expires": "2037-11-15",
"number": "10632197"
},
{
"approved": "2020-11-24",
"country": "United States",
"expires": "2037-11-15",
"number": "10842872"
}
] |
4-Amino-3-butoxy-2-(diethylamino)ethyl ester benzoic acid | 4-Amino-3-butoxy-benzoic acid 2-diethylamino-ethyl ester | 4-Amino-3-n-butoxy-benzoesäure-diäthylaminoäthylester | Benoxinate | BNX | Butoxyaminobenzoyldiethylaminoethanol | Oxibuprocaina | Oxybucaine | Oxybuprocaine | Oxybuprocainum | Oxyriprocaine | hPN3 | Peripheral nerve sodium channel 3 | PN3 | Sodium channel protein type X subunit alpha | Voltage-gated sodium channel subunit alpha Nav1.8 | 3.1.1.8 | Acylcholine acylhydrolase | Butyrylcholine esterase | CHE1 | Choline esterase II | Pseudocholinesterase
|
[
"Altafluor",
"Altafluor",
"Fluorescein Sodium & Benoxinate Hydrochloride Ophthalmic Solution, USP",
"Fluorescein Sodium and Benoxinate Hydrochloride",
"Fluorescein Sodium and Benoxinate Hydrochloride",
"Fluorescein Sodium and Benoxinate Hydrochloride",
"Fluorescein Sodium and Benoxinate Hydrochloride",
"Fluorox",
"Fluress",
"Fluress",
"Fluress Liq Oph",
"Flurox",
"Flurox",
"Minims Benoxinate Hydrochloride 0.4%"
] |
[
"Benoxil",
"Cebesine",
"Conjuncain",
"Dorsacaine",
"Lacrimin",
"Novesin",
"Novesine",
"Prescaina"
] |
[
"Flurox",
"Flurox",
"Fluress",
"Altafluor",
"Fluorescein Sodium and Benoxinate Hydrochloride",
"Altafluor",
"Fluorescein Sodium and Benoxinate Hydrochloride",
"Fluorescein Sodium and Benoxinate Hydrochloride",
"Fluress Liq Oph",
"Fluorox",
"Fluorescein Sodium & Benoxinate Hydrochloride Ophthalmic Solution, USP",
"Fluress",
"Fluorescein Sodium and Benoxinate Hydrochloride"
] |
[
"Q9Y5Y9"
] |
[
"P06276"
] |
[] |
[] |
DB00956
|
Hydrocodone
|
Hydrocodone is a synthetic opioid derivative of codeine.[T116] It is commonly used in combination with [acetaminophen] to control moderate to severe pain. Historically, hydrocodone has been used as a cough suppressant although this has largely been replaced by [dextromethorphan] in current cough and cold formulations. Hydrocodone's more potent metabolite, [hydromorphone] has also found wide use as an analgesic and is frequently used in cases of severe pain. The FDA first approved Hydrocodone for use as part of the cough suppressant syrup Hycodan in March of 1943.[L9025]
|
solid
|
Hydrocodone is indicated for the management of acute pain, sometimes in combination with [acetaminophen] or [ibuprofen], as well as the symptomatic treatment of the common cold and allergic rhinitis in combination with decongestants, antihistamines, and expectorants.[label,L7991]
|
Hydrocodone inhibits pain signaling in both the spinal cord and brain [A176495]. Its actions in the brain also produce euphoria, respiratory depression, and sedation.
|
Hydrocodone binds to the mu opioid receptor (MOR) with the highest affinity followed by the delta opioid receptors (DOR).[A182165] Hydrocodone's agonist effect at the MOR is considered to contribute the most to its analgesic effects. Both MOR and DOR are Gi/o coupled and and produces its signal through activation of inward rectifier potassium (GIRK) channels, inhibition of voltage gated calcium channel opening, and decreased adenylyl cyclase activity.[T116] In the dorsal horn of the spinal cord, activation of pre-synaptic MOR on primary afferents the inhibition of calcium channel opening and increased activity of GIRK channels hyperpolarizes the neuron and prevents release of neurotransmitters. Post-synaptic MOR can also prevent activation of neurons by glutamate through the aforementioned mechanisms.
Hydrocodone can also produce several actions in the brain similarly to other opioids.
Activation of MOR in the periaquaductal gray (PAG) inhibits the GABAergic tone on medulo-spinal neurons.[T116,A176495] This allows these neurons, which project to the dorsal horn of the spinal cord, to suppress pain signalling in secondary afferents by activating inhibitory interneurons. MOR can also inhibit GABAergic neurons in the ventral tegmental area, removing the inhibitory tone on dopaminergic neurons in the nucleus accumbens and contributing to the activation of the brain's reward and addiction pathway. The inhibitory action or MOR likely contributes to respiratory depression, sedation, and suppression of the cough reflex.
Activation of DOR may contribute to analgesia through the above mechanisms but has not been well studied.[A176495]
|
The absolute bioavailability of hydrocodone has not been characterized due to lack of an IV formulation. The liquid formulations of hydrocodone have a Tmax of 0.83-1.33 h.[A182504,A182510] The extended release tablet formulations have a Tmax of 14-16 h.[label] The Cmax remains dose proportional over the range of 2.5-10 mg in liquid formulations and 20-120 mg in extended release formulations.[A182504,A182510,label] Administration with food increases Cmax by about 27% while Tmax and AUC remain the same.[A182564] Administration with 40% ethanol has been observed to increase Cmax 2-fold with an approximate 20% increase in AUC with no change in Tmax. 20% alcohol produces no significant effect.
|
Hydrocodone undergoes oxidative O-demethylation to form [hydromorphone], a more potent active metabolite.[A182114] Though hydromorphone is active it is not present in sufficient quantities to contribute significantly to hydrocodone's therapeutic effects.[A182150] Both hydrocodone and hydromorphone form 6-α- and 6-β-hydroxy metabolites through 6-ketoreduction. The hydroxy metabolites and hydromorphone can form glucuronide conjugates. Hydrocodone also undergoes oxidative N-demthylation to norhydrocodone. O-demethylation is primarily catalyzed by CYP2D6 while N-demethylation is primarily CYP3A4.[A14920]
|
Overdosage with hydrocodone presents as opioid intoxication including respiratory depression, somnolence, coma, skeletal muscle flaccidity, cold and clammy skin, constricted pupils, pulmonary edema, bradycardia, hypotension, partial or complete airway obstruction, atypical snoring, and death.[L7913]
In case of oversdosage the foremost priority is the maintenance of a patent and protected airway with the provision of assisted ventilation if necessary. Supportive measures such as IV fluids, supplemental oxygen, and vasopressors may be used to manage circulatory shock.[L7913] Advanced life support may be necessary in the case of cardiac arrest or arrhythmias. Opioid antagonists such as [naloxone] may be used to reverse the respiratory and circulatory effects of hydrocodone. Emergency monitoring is still required after naloxone administration as the opioid effects may reappear. Additionally, if used in an opioid tolerant patient, naloxone may produce opioid withdrawal symptoms.
|
The half-life of elimination reported for hydrocodone is 7-9 h.[label,A182564,A182582]
|
Hydrocodone is 36% bound to plasma proteins.[label]
|
Most hydrocodone appears to be eliminated via a non-renal route as renal clearance is substantially lower than total apparent clearance.[label] Hepatic metabolism may account for a portion of this, however the slight increase in serum concentration and AUC seen in hepatic impairment indicates a different primary route of elimination.
|
The apparent volume of distribution ranges widely in published literature. The official FDA labeling reports a value of 402 L.[label] Pharmacokinetic studies report values from 210-714 L with higher values associated with higher doses or single dose studies and lower values associated with lower doses and multiple dose studies.[A182498,A182504,A182507,A182510] Hydrocodone has been observed in human breast milk at levels equivalent to 1.6% of the maternal dosage.[A182612] Only 12 of the 30 women studied had detectable concentrations of hydromorphone at mean levels of 0.3 mcg/kg/day.
|
Official FDA labeling reports an apparent clearance of 83 L/h.[label] Pharmacokinetic studies report values ranging from 24.5-58.8 L/h largely dependent on CYP2D6 metabolizer status.[A182498,A182504,A182507,A182510]
|
Organic compounds
|
Alkaloids and derivatives
|
Morphinans
| null |
[
"approved",
"illicit",
"investigational"
] |
[
"R05DA",
"R05D",
"R05",
"R",
"N02AJ",
"N02A",
"N02",
"N",
"N02AJ",
"N02A",
"N02",
"N"
] |
[
"Humans and other mammals"
] |
[
{
"cost": "1.1",
"description": "Hydrocodone-Acetaminophen 10-750 mg tablet",
"unit": "tablet"
},
{
"cost": "1.13",
"description": "Hydrocodone-Ibuprofen 7.5-200 mg tablet",
"unit": "tablet"
},
{
"cost": "60.97",
"description": "Hydrocodone-Acetaminophen 7.5-500 mg/15ml Solution 473ml Bottle",
"unit": "bottle"
},
{
"cost": "0.15",
"description": "Hydrocodone-Homatropine 5-1.5 mg/5ml Syrup",
"unit": "ml"
},
{
"cost": "0.16",
"description": "Hydrocodone-Acetaminophen 7.5-650 mg tablet",
"unit": "tablet"
},
{
"cost": "0.4",
"description": "Hydrocodone-Acetaminophen 5-500 mg tablet",
"unit": "tablet"
},
{
"cost": "0.43",
"description": "Hydrocodone-Acetaminophen 2.5-500 mg tablet",
"unit": "tablet"
},
{
"cost": "0.43",
"description": "Hydrocodone-Acetaminophen 7.5-750 mg tablet",
"unit": "tablet"
},
{
"cost": "0.47",
"description": "Hydrocodone-Acetaminophen 10-650 mg tablet",
"unit": "tablet"
},
{
"cost": "0.47",
"description": "Hydrocodone-Acetaminophen 7.5-500 mg tablet",
"unit": "tablet"
},
{
"cost": "0.5",
"description": "Hydrocodone-Acetaminophen 10-500 mg tablet",
"unit": "tablet"
},
{
"cost": "0.53",
"description": "Hydrocodone-Acetaminophen 10-660 mg tablet",
"unit": "tablet"
},
{
"cost": "0.57",
"description": "Hydrocodone-Acetaminophen 10-325 mg tablet",
"unit": "tablet"
},
{
"cost": "0.57",
"description": "Hydrocodone-Acetaminophen 5-325 mg tablet",
"unit": "tablet"
},
{
"cost": "0.63",
"description": "Hydrocodone-Acetaminophen 7.5-325 mg tablet",
"unit": "tablet"
}
] |
[
{
"approved": "2016-02-23",
"country": "United States",
"expires": "2033-07-23",
"number": "9265760"
},
{
"approved": "2003-07-29",
"country": "United States",
"expires": "2017-06-10",
"number": "6599531"
},
{
"approved": "2002-02-19",
"country": "United States",
"expires": "2017-06-10",
"number": "6348216"
},
{
"approved": "2001-05-08",
"country": "United States",
"expires": "2019-11-01",
"number": "6228398"
},
{
"approved": "2012-11-13",
"country": "United States",
"expires": "2023-11-20",
"number": "8309060"
},
{
"approved": "2002-12-03",
"country": "United States",
"expires": "2017-06-24",
"number": "6488963"
},
{
"approved": "2015-06-23",
"country": "United States",
"expires": "2021-10-30",
"number": "9060940"
},
{
"approved": "2014-08-19",
"country": "United States",
"expires": "2031-12-21",
"number": "8808740"
},
{
"approved": "2004-05-11",
"country": "United States",
"expires": "2021-10-30",
"number": "6733783"
},
{
"approved": "2015-08-04",
"country": "United States",
"expires": "2027-08-24",
"number": "9095614"
},
{
"approved": "2015-08-04",
"country": "United States",
"expires": "2027-08-24",
"number": "9095615"
},
{
"approved": "2013-01-29",
"country": "United States",
"expires": "2021-10-30",
"number": "8361499"
},
{
"approved": "2015-07-21",
"country": "United States",
"expires": "2027-08-24",
"number": "9084816"
},
{
"approved": "2015-12-08",
"country": "United States",
"expires": "2021-10-30",
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] |
(-)-Dihydrocodeinone | 4,5-alpha-Epoxy-3-methoxy-17-methylmorphinan-6-one | Dihydrocodeinone | Hidrocodona | Hydrocodon | Hydrocodone | Hydrocodonum | Hydrocone | Hydroconum | Idrocodone | hMOP | M-OR-1 | MOP | MOR-1 | MOR1 | Mu opiate receptor | Mu opioid receptor | D-OR-1 | DOR-1 | OPRD | Aging-associated gene 8 protein | hSigmaR1 | OPRS1 | SIG-1R | Sigma 1-type opioid receptor | Sigma1-receptor | Sigma1R | SR-BP | SR31747-binding protein | SRBP | 1.14.14.- | Cholesterol 25-hydroxylase | CYP2DL1 | CYPIID6 | Cytochrome P450-DB1 | Debrisoquine 4-hydroxylase | 1,4-cineole 2-exo-monooxygenase | 1,8-cineole 2-exo-monooxygenase | 1.14.14.1 | Albendazole monooxygenase (sulfoxide-forming) | Albendazole sulfoxidase | Cholesterol 25-hydroxylase | CYP3A3 | CYPIIIA3 | CYPIIIA4 | Cytochrome P450 3A3 | Cytochrome P450 HLp | Cytochrome P450 NF-25 | Cytochrome P450-PCN1 | Nifedipine oxidase | Quinine 3-monooxygenase | 1,4-cineole 2-exo-monooxygenase | 1.14.13.- | CYPIIB6 | Cytochrome P450 IIB1 | (R)-limonene 6-monooxygenase | (S)-limonene 6-monooxygenase | (S)-limonene 7-monooxygenase | 1.14.14.1 | CYPIIC17 | CYPIIC19 | Cytochrome P450-11A | Cytochrome P450-254C | Fenbendazole monooxygenase (4'-hydroxylating) | Mephenytoin 4-hydroxylase
|
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"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen Oral",
"Hydrocodone Bitartrate and Aspirin",
"Hydrocodone Bitartrate and Chlorpheniramine Maleate",
"Hydrocodone Bitartrate and Chlorpheniramine Maleate Solution",
"Hydrocodone Bitartrate and Guaifenesin",
"Hydrocodone Bitartrate and Homatropine Methylbromide",
"Hydrocodone Bitartrate and Homatropine Methylbromide",
"Hydrocodone Bitartrate and Homatropine Methylbromide",
"Hydrocodone Bitartrate and Homatropine Methylbromide",
"Hydrocodone Bitartrate and Homatropine Methylbromide",
"Hydrocodone Bitartrate and Homatropine Methylbromide",
"Hydrocodone Bitartrate and Homatropine Methylbromide",
"Hydrocodone Bitartrate and Homatropine Methylbromide",
"Hydrocodone Bitartrate and Homatropine Methylbromide",
"Hydrocodone Bitartrate and Homatropine Methylbromide",
"Hydrocodone Bitartrate and Homatropine Methylbromide",
"Hydrocodone Bitartrate and Homatropine Methylbromide",
"Hydrocodone Bitartrate and Homatropine Methylbromide",
"Hydrocodone Bitartrate and Homatropine Methylbromide",
"Hydrocodone Bitartrate and Homatropine Methylbromide",
"Hydrocodone Bitartrate and Homatropine Methylbromide",
"Hydrocodone Bitartrate and Homatropine Methylbromide",
"Hydrocodone Bitartrate and Homatropine Methylbromide",
"Hydrocodone Bitartrate and Homatropine Methylbromide",
"Hydrocodone Bitartrate and Homatropine Methylbromide",
"Hydrocodone Bitartrate and Homatropine Methylbromide",
"Hydrocodone Bitartrate and Homatropine Methylbromide",
"Hydrocodone Bitartrate and Ibuprofen",
"Hydrocodone Bitartrate and Ibuprofen",
"Hydrocodone Bitartrate and Ibuprofen",
"Hydrocodone Bitartrate and Ibuprofen",
"Hydrocodone Bitartrate and Ibuprofen",
"Hydrocodone Bitartrate and Ibuprofen",
"Hydrocodone Bitartrate and Ibuprofen",
"Hydrocodone Bitartrate and Ibuprofen",
"Hydrocodone Bitartrate and Ibuprofen",
"Hydrocodone Bitartrate and Ibuprofen",
"Hydrocodone Bitartrate and Ibuprofen",
"Hydrocodone Bitartrate and Ibuprofen",
"Hydrocodone Bitartrate and Ibuprofen",
"Hydrocodone Bitartrate and Ibuprofen",
"Hydrocodone Bitartrate and Ibuprofen",
"Hydrocodone Bitartrate and Ibuprofen",
"Hydrocodone Bitartrate and Ibuprofen",
"Hydrocodone Bitartrate and Ibuprofen",
"Hydrocodone Bitartrate and Ibuprofen",
"Hydrocodone Bitartrate and Ibuprofen",
"Hydrocodone Bitartrate and Ibuprofen",
"Hydrocodone Bitartrate and Ibuprofen",
"Hydrocodone Bitartrate and Ibuprofen",
"Hydrocodone Bitartrate and Ibuprofen",
"Hydrocodone Bitartrate and Ibuprofen",
"Hydrocodone Bitartrate and Ibuprofen",
"Hydrocodone Bitartrate and Ibuprofen",
"Hydrocodone Bitartrate and Ibuprofen",
"Hydrocodone Bitartrate and Ibuprofen",
"Hydrocodone Bitartrate and Ibuprofen",
"Hydrocodone bitartrate and ibuprofen",
"Hydrocodone bitartrate and ibuprofen",
"Hydrocodone bitartrate and ibuprofen",
"Hydrocodone bitartrate and ibuprofen",
"Hydrocodone Bitartrate and Ibuprofen",
"Hydrocodone Bitartrate and Ibuprofen",
"Hydrocodone Bitartrate and Ibuprofen",
"Hydrocodone bitartrate and pseudoephedrine hydrochloride solution",
"Hydrocodone Bitartrate Chlorpheniramine Maleate and Pseudoephedrine Hydrochloride",
"Hydrocodone Bitartrate, Chlorpheniramine Maleate and Pseudoephedrine Hydrochloride",
"Hydrocodone Bitartrate, Chlorpheniramine Maleate, and Pseudoephedrine HCl",
"Hydrocodone Bitartrate, Chlorpheniramine Maleate, and Pseudoephedrine Hydrochloride Oral Solution",
"Hydrocodone Bitatrate and Acetaminophen",
"Hydrocodone Bitatrate and Acetaminophen",
"Hydrocodone Polistirex and Chlorpheniramine Polisitrex",
"Hydrocodone Polistirex and Chlorpheniramine Polisitrex",
"Hydrocodone Polistirex and Chlorpheniramine Polisitrex",
"Hydrocodone Polistirex and Chlorpheniramine Polistirex",
"Hydrocodone Polistirex and Chlorpheniramine Polistirex",
"Hydrocodone Polistirex and Chlorpheniramine Polistirex",
"Hydrocodone Polistirex and Chlorpheniramine Polistirex Extended-Release",
"Hydrocodone Polistirex and Chlorpheniramine Polistirex extended-release",
"Hydrocodone Polistirex and Chlorpheniramine Polistirex extended-release",
"Hydrocodone Polistirex and Chlorpheniramine Polistirex extended-release",
"Hydrocodone Polistirex and Chlorpheniramine Polistirex extended-release",
"Hydrocodone Polistirex and Chlorpheniramine Polistirex extended-release",
"Hydrocodone Polistirex and Chlorpheniramine Polistirex Pennkinetic",
"Hydrocodone Polistirex and Chlorpheniramine Polistirex Pennkinetic",
"Hydrocodone/apap",
"Hydrocodone/apap",
"Hydrocodone/apap",
"Hydrocodone/APAP",
"Hydrocodone/Guaifenesin",
"Hydromet",
"Hydromet",
"Hyrdrocodone Apap",
"Hysingla ER",
"Hysingla ER",
"Hysingla ER",
"Hysingla ER",
"Hysingla ER",
"Hysingla ER",
"Hysingla ER",
"HyTan",
"Ibucodone",
"Ibudone",
"Ibudone",
"Ibudone",
"Ibudone",
"Lorcet",
"Lorcet",
"Lorcet",
"Lorcet",
"Lorcet",
"Lorcet 10/650",
"Lorcet 10/650",
"Lorcet Hd",
"Lorcet Hd",
"Lorcet Hd",
"Lorcet Plus",
"Lorcet Plus",
"Lorcet Plus",
"Lorcet Plus",
"Lorcet Plus",
"Lorcet Plus",
"Lorcet Plus",
"Lortab",
"Lortab",
"Lortab",
"Lortab",
"Lortab",
"Lortab",
"Lortab",
"Lortab",
"Lortab",
"Lortab",
"Lortab",
"Lortab",
"Lortab",
"Lortab",
"Lortab",
"Lortab",
"Lortab",
"Lortab",
"Lortab",
"Lortab",
"Lortab",
"Lortab 10/325",
"Lortab 10/325",
"Lortab 5/325",
"Lortab 5/325",
"Lortab 7.5/325",
"Lortab 7.5/325",
"Maxidone",
"Maxidone",
"Mercodol With Decapryn",
"Norco",
"Norco",
"Norco",
"Norco",
"Norco",
"Norco",
"Norco",
"Norco",
"Norco",
"Norco",
"Norco",
"Norco",
"Norco",
"Norco",
"Norco",
"Norco",
"Norco",
"Norco",
"Novahistex Dh",
"Novahistex Dh Expectorant",
"Novahistine Dh",
"Obredon",
"Obredon",
"P-Tuss",
"Pancof HC",
"Pdp-hydrocodone",
"Ratio-calmydone",
"Ratio-coristex-DH",
"Reprexain",
"Reprexain",
"Reprexain",
"Reprexain",
"Reprexain",
"Reprexain",
"Reprexain",
"Reprexain",
"Reprexain",
"Reprexain",
"Reprexain",
"Rezira",
"Robidone 1mg/ml Syr",
"Robidone Syr 1mg/ml",
"Solucodan Syrup",
"Solucodan-H",
"Stagesic",
"Theracodophen-325",
"Theracodophen-650",
"Theracodophen-750",
"Theracodophen-Low-90",
"Topical Pain",
"Triaminic Expectorant Dh Syrup",
"Tussaminic Dh Forte Syrup",
"Tussaminic Dh Pediatric Syrup",
"Tussicaps",
"TussiCaps",
"TussiCaps",
"TussiCaps",
"TussiCaps",
"Tussicaps Extended-release",
"Tussicaps Extended-release",
"Tussigon",
"Tussigon",
"Tussionex",
"Tussionex",
"Tussionex Pennkinetic",
"Tussionex Pennkinetic",
"Tussionex Pennkinetic Extended-Release",
"Vantrela ER",
"Vantrela ER",
"Vantrela ER",
"Vantrela ER",
"Vantrela ER",
"Vasofrinic Dh",
"Vicodin",
"Vicodin",
"Vicodin",
"Vicodin",
"Vicodin",
"Vicodin ES",
"Vicodin ES",
"Vicodin ES",
"Vicodin ES",
"Vicodin ES",
"Vicodin HP",
"Vicodin HP",
"Vicodin Hp",
"Vicodin HP",
"Vicoprofen",
"Vicoprofen",
"Vicoprofen",
"Vituz",
"WellTuss HC",
"Xodol",
"Xodol",
"Xodol",
"Xodol",
"Xodol",
"Xodol",
"Xodol",
"Xodol",
"Xodol",
"Xodol 10/300",
"Xodol 5/300",
"Xodol 7.5/300",
"Xylon 10",
"Zamicet",
"Zamicet",
"Zamicet",
"Zamicet",
"Zamicet",
"Zohydro",
"Zohydro",
"Zohydro",
"Zohydro",
"Zohydro",
"Zohydro",
"Zohydro",
"Zohydro",
"Zohydro",
"Zohydro",
"Zohydro",
"Zohydro",
"Zohydro ER",
"Zohydro ER",
"Zohydro ER",
"Zohydro ER",
"Zohydro ER",
"Zohydro ER",
"Zolvit",
"Zolvit",
"Zutripro",
"Zydone",
"Zydone",
"Zydone",
"Zydone",
"Zyfrel"
] |
[] |
[
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Lortab",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Ibuprofen",
"Hydrocodone Bitartrate and Ibuprofen",
"Hydrocodone Bitartrate and Acetaminophen",
"Reprexain",
"Reprexain",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Ibuprofen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Atuss HS Tannate",
"Hydrocodone Polistirex and Chlorpheniramine Polistirex",
"Zydone",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Ibuprofen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Norco",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Lortab",
"Antitussive hydrocodone bitartrate and homatropine methylbromide",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Theracodophen-750",
"Theracodophen-Low-90",
"Hydrocodone Bitartrate And Acetaminophen",
"Lortab",
"Theracodophen-650",
"Theracodophen-325",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Vicoprofen",
"Ibudone",
"Ibudone",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Vicodin",
"Vicodin ES",
"Vicodin HP",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"HyTan",
"WellTuss HC",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Xodol",
"Xodol",
"Xodol",
"Hydrocodone Bitartrate and Homatropine Methylbromide",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Homatropine Methylbromide",
"P-Tuss",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Tussicaps",
"Norco",
"Norco",
"Tussicaps Extended-release",
"Tussicaps Extended-release",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Vicodin ES",
"Vicodin HP",
"Vicodin",
"Xodol",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Ibuprofen",
"Hydrocodone/Guaifenesin",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartate and Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Pancof HC",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hycomine",
"Hycomine",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Xodol",
"Xodol",
"Tussionex Pennkinetic Extended-Release",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Lorcet Plus",
"Norco",
"Norco",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen Oral",
"Hydrocodone Bitartrate and Homatropine Methylbromide",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate and acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hycet",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Lorcet",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Homatropine Methylbromide",
"Hydrocodone Bitartrate and Homatropine Methylbromide",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate and Ibuprofen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Lortab",
"Lortab",
"Lortab",
"Lortab",
"Co-gesic",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartate and Acetaminophen",
"Hydrocodone Bitartrate and Ibuprofen",
"Hydrocodone Bitartrate and Acetaminophen",
"Norco",
"Hydrocodone Bitartrate and Ibuprofen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Lorcet 10/650",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Vicodin ES",
"Hydrocodone Bitartrate and Acetaminophen",
"Xodol 5/300",
"Xodol 7.5/300",
"Xodol 10/300",
"Lortab",
"Lortab",
"Lortab",
"Zydone",
"Zydone",
"Zydone",
"Hydrocodone Bitartrate and Acetaminophen",
"Lorcet Plus",
"Hycet",
"Hydrocodone Bitartate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Lortab",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Lortab",
"Hydrocodone Bitartrate and Acetaminophen",
"Norco",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Ibuprofen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Reprexain",
"Reprexain",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Polistirex and Chlorpheniramine Polisitrex",
"Reprexain",
"Stagesic",
"Zolvit",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Zamicet",
"Zamicet",
"Hydrocodone Bit/apap",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hycofenix",
"Flowtuss",
"Hydrocodone Bitartrate and Acetaminophen",
"Hycet",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Zamicet",
"Hydrocodone/apap",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Zolvit",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Polistirex and Chlorpheniramine Polistirex Extended-Release",
"Hydrocodone Bitartrate and Acetaminophen",
"Vicodin Hp",
"Hydrocodone Bitartrate and Acetaminophen",
"Lortab",
"Lortab",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate, Chlorpheniramine Maleate, and Pseudoephedrine Hydrochloride Oral Solution",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Chlorpheniramine Maleate Solution",
"Hydrocodone Polistirex and Chlorpheniramine Polistirex Pennkinetic",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartate and Acetaminophen",
"Vicodin ES",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Homatropine Methylbromide",
"Lortab",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone bitartrate and pseudoephedrine hydrochloride solution",
"Vicoprofen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate",
"Norco",
"Zamicet",
"Zamicet",
"Lortab",
"Vicodin",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Lorcet Plus",
"Lorcet",
"Lortab",
"Vicoprofen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Polistirex and Chlorpheniramine Polistirex Pennkinetic",
"Tussionex Pennkinetic",
"Lortab",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Polistirex and Chlorpheniramine Polisitrex",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate and Ibuprofen",
"Lortab 5/325",
"Lortab 7.5/325",
"Lortab 10/325",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Norco",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Maxidone",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Rezira",
"Vituz",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Zyfrel",
"Obredon",
"Tussigon",
"Lorcet Plus",
"Lortab",
"Lortab",
"Lorcet 10/650",
"Reprexain",
"Reprexain",
"Reprexain",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Ibuprofen",
"Hydrocodone Polistirex and Chlorpheniramine Polistirex",
"Hydrocodone Bitartate and Acetaminophen",
"Maxidone",
"Hydrocodone Polistirex and Chlorpheniramine Polistirex",
"Hydrocodone Bitartate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Ibuprofen",
"Hydrocodone Bitartrate and Ibuprofen",
"Hydrocodone Bitartate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Vicodin",
"Xylon 10",
"Lortab 5/325",
"Lortab 7.5/325",
"Lortab 10/325",
"Hydrocodone Bitartrate and Acetaminophen",
"Lorcet",
"Lorcet Plus",
"Lorcet Hd",
"Lorcet",
"Lorcet Plus",
"Lorcet Hd",
"Hydrocodone Bitartrate and Ibuprofen",
"Hydrocodone Bitartate and Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Norco",
"Norco",
"Norco",
"Norco",
"Hydrocodone Bitartrate and Acetaminophen",
"Tussigon",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Ibuprofen",
"Hycofenix",
"Flowtuss",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Polistirex and Chlorpheniramine Polisitrex",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Lorcet",
"Lorcet Plus",
"Lorcet Hd",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Tussionex Pennkinetic",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate and Ibuprofen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Xodol",
"Xodol",
"Xodol",
"Lortab",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Homatropine Methylbromide",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Homatropine Methylbromide",
"Obredon",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate and Homatropine Methylbromide",
"Hydrocodone Bitartrate and Homatropine Methylbromide",
"Vicodin HP",
"Vicodin ES",
"Vicodin",
"Hydrocodone Bitartrate and Homatropine Methylbromide",
"Hydrocodone Bitartrate and Homatropine Methylbromide",
"Hydrocodone Bitartrate and Homatropine Methylbromide",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Homatropine Methylbromide",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Homatropine Methylbromide",
"Hydrocodone Bitartrate and Acetaminophen",
"Ibudone",
"Ibudone",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Ibuprofen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydromet",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Homatropine Methylbromide",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Ibuprofen",
"Hydrocodone Bitartrate and Ibuprofen",
"Hydrocodone Bitartrate and Ibuprofen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate and Ibuprofen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Ibuprofen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate, Chlorpheniramine Maleate and Pseudoephedrine Hydrochloride",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Polistirex and Chlorpheniramine Polistirex extended-release",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Ibuprofen",
"Hydrocodone Bitartrate and Ibuprofen",
"Hydrocodone Bitartrate and Ibuprofen",
"Hydrocodone Bitartrate and Ibuprofen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartate and Acetaminophen",
"Hydrocodone Bitartrate and Ibuprofen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Homatropine Methylbromide",
"HYDROCODONE BITARTRATE and ACETAMINOPHEN",
"Hydrocodone Bitartrate and Chlorpheniramine Maleate",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"TussiCaps",
"TussiCaps",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Norco",
"Norco",
"Norco",
"Hydrocodone Bitartrate",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone /apap",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hycodan",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Ibuprofen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hyrdrocodone Apap",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Ibuprofen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Polistirex and Chlorpheniramine Polistirex extended-release",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Ibuprofen",
"Reprexain",
"Reprexain",
"Reprexain",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Norco",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"TussiCaps",
"TussiCaps",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitatrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartate and Acetaminophen",
"Hydrocodone/apap",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate Chlorpheniramine Maleate and Pseudoephedrine Hydrochloride",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone bitartrate and ibuprofen",
"Hydrocodone bitartrate and ibuprofen",
"Hydrocodone bitartrate and ibuprofen",
"Hydrocodone bitartrate and ibuprofen",
"Topical Pain",
"Hydrocodone Bitatrate and Acetaminophen",
"Hydrocodone Bitartrate and Ibuprofen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Ibuprofen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Guaifenesin",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Zutripro",
"Hydrocodone Bitartrate and Ibuprofen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydromet",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hycodan",
"Hycodan",
"Hydrocodone bitartrate and acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate, Chlorpheniramine Maleate, and Pseudoephedrine HCl",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"HYDROCODONE BITARTRATE and ACETAMINOPHEN",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Polistirex and Chlorpheniramine Polistirex extended-release",
"Hydrocodone Polistirex and Chlorpheniramine Polistirex extended-release",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Homatropine Methylbromide",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Aspirin",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Homatropine Methylbromide",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hycodan",
"Tussionex",
"Novahistex Dh",
"Novahistine Dh",
"Tussaminic Dh Forte Syrup",
"Dimetane Expectorant-DC Syr",
"Hycomine",
"Triaminic Expectorant Dh Syrup",
"Tussaminic Dh Pediatric Syrup",
"Hycomine-S",
"Mercodol With Decapryn",
"Novahistex Dh Expectorant",
"Caldomine Dh Adulte",
"Caldomine Dh Enfant",
"Ratio-coristex-DH",
"Coristine-DH Liq",
"Ibucodone",
"Codofen",
"Dimetane Expectorant Dc",
"Ratio-calmydone",
"Vasofrinic Dh",
"Dalmacol",
"Dalmacol",
"Tussionex",
"Hydrocodone Bitartrate And Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone APAP",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Homatropine Methylbromide",
"Hydrocodone Bitartrate and Homatropine Methylbromide",
"Hydrocodone Bitartrate and Acetaminophen",
"Norco",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone/apap",
"Hydrocodone/APAP",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Polistirex and Chlorpheniramine Polistirex extended-release",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Solucodan-H",
"Solucodan Syrup",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Homatropine Methylbromide",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen",
"Hydrocodone Bitartrate and Acetaminophen"
] |
[
"P35372",
"P41143",
"Q99720"
] |
[
"P10635",
"P08684",
"P20813",
"P33261"
] |
[] |
[] |
DB01192
|
Oxymorphone
|
An opioid analgesic with actions and uses similar to those of morphine, apart from an absence of cough suppressant activity. It is used in the treatment of moderate to severe pain, including pain in obstetrics. It may also be used as an adjunct to anesthesia (From Martindale, The Extra Pharmacopoeia, 30th ed, p1092). On June 8, 2017, FDA requested Endo Pharmaceuticals to remove the medication from the market due to opioid misuse and abuse risks associated with the product's injectable reformulation.
|
solid
|
For the treatment of moderate-to-severe pain.
|
Oxymorphone is a semi-synthetic opioid substitute for morphine. It is a potent analgesic. Opioid analgesics exert their principal pharmacologic effects on the CNS and the gastrointestinal tract. The principal actions of therapeutic value are analgesia and sedation. Opioids produce respiratory depression by direct action on brain stem respiratory centers. The mechanism of respiratory depression involves a reduction in the responsiveness of the brain stem respiratory centers to increases in carbon dioxide tension and to electrical stimulation.
|
Oxymorphone interacts predominantly with the opioid mu-receptor. These mu-binding sites are discretely distributed in the human brain, with high densities in the posterior amygdala, hypothalamus, thalamus, nucleus caudatus, putamen, and certain cortical areas. They are also found on the terminal axons of primary afferents within laminae I and II (substantia gelatinosa) of the spinal cord and in the spinal nucleus of the trigeminal nerve. Also, it has been shown that oxymorphone binds to and inhibits GABA inhibitory interneurons via mu-receptors. These interneurons normally inhibit the descending pain inhibition pathway. So, without the inhibitory signals, pain modulation can proceed downstream.
| null |
Oxymorphone undergoes extensive hepatic metabolism in humans. After a 10 mg oral dose, 49% was excreted over a five-day period in the urine. Of this, 82% was excreted in the first 24 hours after administration. The recovered drug-related products contained the oxymorphone (1.9%), the conjugate of oxymorphone (44.1%), the 6(beta)-carbinol produced by 6-keto reduction of oxymorphone (0.3%), and the conjugates of 6(beta)-carbinol (2.6%) and 6(alpha)-carbinol (0.1%).
|
Oxymorphone overdosage is characterized by respiratory depression, extreme somnolence progressing to stupor or coma, skeletal muscle flaccidity, cold and clammy skin, and sometimes bradycardia and hypotension. Patients experiencing an overdose may develop apnea, circulatory collapse, and cardiac arrest. Intravenous mouse LD<sub>50</sub> is 172 mg/kg.
|
1.3 (+/-0.7) hours
| null |
Oxymorphone is highly metabolized, principally in the liver, and undergoes reduction or conjugation with glucuronic acid to form both active and inactive products. Because oxymorphone is extensively metabolized, <1% of the administered dose is excreted unchanged in the urine.
| null | null |
Organic compounds
|
Benzenoids
|
Phenanthrenes and derivatives
| null |
[
"approved",
"investigational",
"vet_approved"
] |
[
"N02AA",
"N02A",
"N02",
"N"
] |
[
"Humans and other mammals"
] |
[
{
"cost": "2.3",
"description": "Opana ER 5 mg 12 Hour tablet",
"unit": "tablet"
},
{
"cost": "3.0",
"description": "Opana er 7.5 mg tablet",
"unit": "tablet"
},
{
"cost": "3.13",
"description": "Numorphan 1 mg/ml ampul",
"unit": "ml"
},
{
"cost": "3.3",
"description": "Opana ER 7.5 mg 12 Hour tablet",
"unit": "tablet"
},
{
"cost": "3.95",
"description": "Opana er 10 mg tablet",
"unit": "tablet"
},
{
"cost": "4.4",
"description": "Opana ER 10 mg 12 Hour tablet",
"unit": "tablet"
},
{
"cost": "5.53",
"description": "Opana er 5 mg tablet",
"unit": "tablet"
},
{
"cost": "5.82",
"description": "Opana ER 15 mg 12 Hour tablet",
"unit": "tablet"
},
{
"cost": "7.17",
"description": "Opana ER 20 mg 12 Hour tablet",
"unit": "tablet"
},
{
"cost": "9.26",
"description": "Opana er 15 mg tablet",
"unit": "tablet"
},
{
"cost": "9.76",
"description": "Opana ER 30 mg 12 Hour tablet",
"unit": "tablet"
},
{
"cost": "12.12",
"description": "Opana er 20 mg tablet",
"unit": "tablet"
},
{
"cost": "12.42",
"description": "Opana ER 40 mg 12 Hour tablet",
"unit": "tablet"
},
{
"cost": "17.39",
"description": "Opana er 30 mg tablet",
"unit": "tablet"
},
{
"cost": "21.82",
"description": "Opana er 40 mg tablet",
"unit": "tablet"
}
] |
[
{
"approved": "1997-09-02",
"country": "United States",
"expires": "2013-09-09",
"number": "5662933"
},
{
"approved": "2007-10-02",
"country": "United States",
"expires": "2023-02-04",
"number": "7276250"
},
{
"approved": "2012-11-13",
"country": "United States",
"expires": "2023-11-20",
"number": "8309060"
},
{
"approved": "2012-02-14",
"country": "United States",
"expires": "2024-10-10",
"number": "8114383"
},
{
"approved": "2014-08-19",
"country": "United States",
"expires": "2027-06-21",
"number": "8808737"
},
{
"approved": "2014-10-28",
"country": "United States",
"expires": "2029-11-22",
"number": "8871779"
},
{
"approved": "2012-06-05",
"country": "United States",
"expires": "2025-09-15",
"number": "8192722"
},
{
"approved": "2011-12-13",
"country": "United States",
"expires": "2023-11-20",
"number": "8075872"
},
{
"approved": "2010-12-14",
"country": "United States",
"expires": "2029-07-10",
"number": "7851482"
},
{
"approved": "2012-12-11",
"country": "United States",
"expires": "2023-02-04",
"number": "8329216"
},
{
"approved": "2012-11-13",
"country": "United States",
"expires": "2023-02-04",
"number": "8309122"
},
{
"approved": "2012-11-13",
"country": "United States",
"expires": "2023-02-04",
"number": "8309112"
}
] |
(14S)-14-Hydroxydihydromorphinone | 14-Hydroxydihydromorphinone | Dihydrohydroxymorphinone | Dihydroxymorphinone | Oximorfona | Oximorphonum | Oxymorphone | Oxymorphonum | hMOP | M-OR-1 | MOP | MOR-1 | MOR1 | Mu opiate receptor | Mu opioid receptor | D-OR-1 | DOR-1 | OPRD | 1,4-cineole 2-exo-monooxygenase | 1,8-cineole 2-exo-monooxygenase | 1.14.14.1 | Albendazole monooxygenase (sulfoxide-forming) | Albendazole sulfoxidase | Cholesterol 25-hydroxylase | CYP3A3 | CYPIIIA3 | CYPIIIA4 | Cytochrome P450 3A3 | Cytochrome P450 HLp | Cytochrome P450 NF-25 | Cytochrome P450-PCN1 | Nifedipine oxidase | Quinine 3-monooxygenase | 1.14.14.- | Cholesterol 25-hydroxylase | CYP2DL1 | CYPIID6 | Cytochrome P450-DB1 | Debrisoquine 4-hydroxylase
|
[
"Numorphan",
"Numorphan",
"Numorphan",
"Numorphan Injection 1.5mg/ml",
"Numorphan Suppository 5mg",
"Opana",
"Opana",
"Opana",
"Opana",
"Opana",
"Opana",
"Opana",
"Opana ER",
"Opana ER",
"Opana ER",
"Opana ER",
"Opana ER",
"Opana ER",
"Opana ER",
"Opana ER",
"Opana ER",
"Opana ER",
"Opana ER",
"Opana ER",
"Opana ER",
"Opana ER",
"Opana ER",
"Opana ER",
"Opana ER",
"Opana ER",
"Opana ER",
"Opana ER",
"Opana ER",
"Opana ER",
"Opana ER",
"Opana ER",
"Opana ER",
"Opana ER",
"Opana ER",
"Opana ER",
"Opana ER",
"Opana ER",
"Opana ER",
"Opana ER",
"Opana ER",
"Opana ER",
"Opana ER",
"Opana ER",
"Opana ER",
"Opana ER",
"Opana ER",
"Opana ER",
"Opana ER",
"Oxymorphone Hydrochloride",
"Oxymorphone Hydrochloride",
"Oxymorphone Hydrochloride",
"Oxymorphone Hydrochloride",
"Oxymorphone Hydrochloride",
"Oxymorphone hydrochloride",
"Oxymorphone hydrochloride",
"Oxymorphone hydrochloride",
"Oxymorphone hydrochloride",
"Oxymorphone hydrochloride",
"Oxymorphone hydrochloride",
"Oxymorphone hydrochloride",
"Oxymorphone hydrochloride",
"Oxymorphone hydrochloride",
"Oxymorphone hydrochloride",
"Oxymorphone hydrochloride",
"Oxymorphone hydrochloride",
"Oxymorphone hydrochloride",
"Oxymorphone hydrochloride",
"Oxymorphone hydrochloride",
"Oxymorphone hydrochloride",
"Oxymorphone hydrochloride",
"Oxymorphone hydrochloride",
"Oxymorphone hydrochloride",
"Oxymorphone hydrochloride",
"Oxymorphone hydrochloride",
"Oxymorphone hydrochloride",
"Oxymorphone Hydrochloride",
"Oxymorphone Hydrochloride",
"Oxymorphone Hydrochloride",
"Oxymorphone Hydrochloride",
"Oxymorphone Hydrochloride",
"Oxymorphone Hydrochloride",
"Oxymorphone Hydrochloride",
"Oxymorphone Hydrochloride",
"Oxymorphone Hydrochloride",
"Oxymorphone Hydrochloride",
"Oxymorphone hydrochloride",
"Oxymorphone hydrochloride",
"Oxymorphone hydrochloride",
"Oxymorphone hydrochloride",
"Oxymorphone hydrochloride",
"Oxymorphone hydrochloride",
"Oxymorphone hydrochloride",
"Oxymorphone Hydrochloride",
"Oxymorphone Hydrochloride",
"Oxymorphone Hydrochloride",
"Oxymorphone Hydrochloride",
"Oxymorphone Hydrochloride",
"Oxymorphone Hydrochloride",
"Oxymorphone Hydrochloride",
"Oxymorphone Hydrochloride",
"Oxymorphone Hydrochloride",
"Oxymorphone Hydrochloride",
"Oxymorphone hydrochloride",
"Oxymorphone hydrochloride",
"Oxymorphone hydrochloride",
"Oxymorphone hydrochloride",
"Oxymorphone hydrochloride",
"Oxymorphone hydrochloride",
"Oxymorphone hydrochloride",
"Oxymorphone hydrochloride",
"Oxymorphone Hydrochloride",
"Oxymorphone Hydrochloride",
"Oxymorphone Hydrochloride Extended-Release",
"Oxymorphone Hydrochloride Extended-Release",
"Oxymorphone Hydrochloride Extended-Release",
"Oxymorphone Hydrochloride Extended-Release",
"Oxymorphone Hydrochloride Extended-Release",
"Oxymorphone Hydrochloride Extended-Release",
"Oxymorphone Hydrochloride Extended-Release"
] |
[] |
[] |
[
"P35372",
"P41143"
] |
[
"P08684",
"P10635"
] |
[] |
[] |
DB00899
|
Remifentanil
|
Remifentanil (marketed by Abbott as Ultiva) is a potent ultra short-acting synthetic opioid given to patients during surgery for pain relief and adjunctive to an anaesthetic. Remifentanil is a specific mu-type-opioid receptor agonist which means it reduces sympathetic nervous system tone, and causes respiratory depression and analgesia.
|
solid
|
For use during the induction and maintenance of general anesthesia.
|
Remifentanil is an opioid agonist with rapid onset and peak effect and ultra-short duration of action. The opioid activity of remifentanil is antagonized by opioid antagonists such as naloxone. The analgesic effects of remifentanil are rapid in onset and offset. Its effects and side effects are dose dependent and similar to other opioids. Remifentanil in humans has a rapid blood-brain equilibration half-time of 1 ± 1 minutes (mean ± SD) and a rapid onset of action.
|
Remifentanil is a µ-opioid agonist with rapid onset and peak effect, and short duration of action. The µ-opioid activity of remifentanil is antagonized by opioid antagonists such as naloxone.
| null |
By hydrolysis of the propanoic acid-methyl ester linkage by nonspecific blood and tissue esterases.
| null |
1-20 minutes
|
70% (bound to plasma proteins)
|
Remifentanil is an esterase-metabolized opioid. The carboxylic acid metabolite is essentially inactive (1/4600 as potent as remifentanil in dogs) and is excreted by the kidneys with an elimination half-life of approximately 90 minutes.
|
* 350 mL/kg
* 452 ± 144 mL/kg [neonates]
* 223 ± 30.6 mL/kg [adolescents]
|
* 40 mL/min/kg [young, healthy adults]
|
Organic compounds
|
Organic acids and derivatives
|
Carboxylic acids and derivatives
|
Amino acids, peptides, and analogues
|
[
"approved"
] |
[
"N01AH",
"N01A",
"N01",
"N"
] |
[
"Humans and other mammals"
] |
[
{
"cost": "30.19",
"description": "Ultiva 1 mg vial",
"unit": "vial"
},
{
"cost": "57.2",
"description": "Ultiva 2 mg vial",
"unit": "vial"
},
{
"cost": "118.15",
"description": "Ultiva 5 mg vial",
"unit": "vial"
}
] |
[
{
"approved": "1991-05-28",
"country": "United States",
"expires": "2010-07-12",
"number": "5019583"
},
{
"approved": "1999-02-02",
"country": "United States",
"expires": "2018-03-10",
"number": "5866591"
}
] |
Remifentanil | Remifentanilo | Remifentanyl | hMOP | M-OR-1 | MOP | MOR-1 | MOR1 | Mu opiate receptor | Mu opioid receptor | D-OR-1 | DOR-1 | OPRD | K-OR-1 | KOR-1 | OPRK
|
[
"Remifentanil for Injection",
"Remifentanil for Injection",
"Remifentanil for Injection",
"Remifentanil for Injection",
"Remifentanil Hydrochloride",
"Remifentanil Hydrochloride",
"Remifentanil Hydrochloride",
"Remifentanil Hydrochloride",
"Remifentanil Hydrochloride",
"Remifentanil Hydrochloride",
"Remifentanil Hydrochloride",
"Remifentanil Hydrochloride",
"Remifentanil Hydrochloride",
"Remifentanil hydrochloride",
"Remifentanil hydrochloride",
"Remifentanil hydrochloride",
"Remifentanil Hydrochloride for Injection",
"Remifentanil Hydrochloride for Injection",
"Remifentanil Hydrochloride for Injection",
"Ultiva",
"Ultiva",
"Ultiva",
"Ultiva",
"Ultiva",
"Ultiva",
"Ultiva",
"Ultiva",
"Ultiva",
"Ultiva",
"Ultiva",
"Ultiva",
"Ultiva"
] |
[] |
[] |
[
"P35372",
"P41143",
"P41145"
] |
[] |
[] |
[] |
DB00472
|
Fluoxetine
|
Fluoxetine is a 2nd generation antidepressant categorized as a selective serotonin reuptake inhibitor (SSRI).[A181673] It gained FDA approval in 1987 and although it was initially intended for the treatment of depression, today it is commonly prescribed to manage depression in addition to various other pathologies.[L7721]
|
solid
|
Fluoxetine is indicated for both acute and maintenance treatment of major depressive disorder, obsessive compulsive disorder, and bulimia nervosa; however, it is only indicated for acute treatment of panic disorder independent of whether agoraphobia is present.[L7664] Fluoxetine may also be used in combination with olanzapine to treat depression related to Bipolar I Disorder, and treatment resistant depression.[L7664] Fluoxetine is additionally indicated for the treatment of female patients with premenstrual dysphoric disorder (PMDD).[L40833]
|
Fluoxetine blocks the serotonin reuptake transporter in the presynaptic terminal, which ultimately results in sustained levels of 5-hydroxytryptamine (5-HT) in certain brain areas.[L7721] However, fluoxetine binds with relatively poor affinity to 5-HT, dopaminergic, adrenergic, cholinergic, muscarinic, and histamine receptors which explains why it has a far more desirable adverse effect profile compared to earlier developed classes of antidepressants such as tricyclic antidepressants.[L7721][A181673]
|
The monoaminergic hypothesis of depression emerged in 1965 and linked depression with dysfunction of neurotransmitters such as noradrenaline and serotonin.[L7721] Indeed, low levels of serotonin have been observed in the cerebrospinal fluid of patients diagnosed with depression.[A181793] As a result of this hypothesis, drugs that modulate levels of serotonin such as fluoxetine were developed.[L7721]
Fluoxetine is a selective serotonin reuptake inhibitor (SSRI) and as the name suggests, it exerts it's therapeutic effect by inhibiting the presynaptic reuptake of the neurotransmitter serotonin.[A181673] As a result, levels of 5-hydroxytryptamine (5-HT) are increased in various parts of the brain.[L7721] Further, fluoxetine has high affinity for 5-HT transporters, weak affinity for noradrenaline transporters and no affinity for dopamine transporters indicating that it is 5-HT selective.[L7721]
Fluoxetine interacts to a degree with the 5-HT<sub>2C</sub> receptor and it has been suggested that through this mechanism, it is able to increase noradrenaline and dopamine levels in the prefrontal cortex.[L7721]
|
The oral bioavailability of fluoxetine is <90% as a result of hepatic first pass metabolism.[L7721]
In a bioequivalence study, the Cmax of fluoxetine 20 mg for the established reference formulation was 11.754 ng/mL while the Cmax for the proposed generic formulation was 11.786 ng/ml.[A185285]
Fluoxetine is very lipophilic and highly plasma protein bound, allowing the drug and it's active metabolite, norfluoxetine, to be distributed to the brain.[L7721]
|
Fluoxetine is metabolized to norfluoxetine by CYP1A2, CYP2B6, CYP2C9, CYP2C19, CYP2D6, CYP3A4, and CYP3A5 upon ingestion.[L7721][A16881] Although all of the mentioned enzymes contribute to N-demethylation of fluoxetine, CYP2D6, CYP2C9 and CYP3A4 appear to be the major contributing enzymes for phase I metabolism.[A16881] In addition, there is evidence to suggest that CYP2C19 and CYP3A4 mediate O-dealkylation of fluoxetine and norfluoxetine to produce para-trifluoromethylphenol which is subsequently metabolized to hippuric acid.[A185246][A185255] Both fluoxetine and norfluoxetine undergo glucuronidation to facilitate excretion.[L7721]
Notably, both the parent drug and active metabolite inhibit CYP2D6 isozymes, and as a result patients who are being treated with fluoxetine are susceptible to drug interactions.[L7721][L162]
|
In a report that included 234 fluoxetine overdose cases, it was concluded that symptoms resulting from fluoxetine overdose were generally minor and short in duration.[A181898] The most common overdose adverse effects included drowsiness, tremor, tachycardia, nausea and vomiting, and providing the patient with aggressive supportive care was the recommended intervention.[A181892][A181898]
Despite this evidence, more severe adverse effects have been linked to fluoxetine ingestion although most of these reports involved co-ingestion with other substances or drugs as well as other factors.[A181892] For example, there is a case report that details a patient who ingested 1400 mg of fluoxetine in a suicide attempt and as a result, experienced a generalized seizure three hours later.[A181892] In a separate case, a 14 year old patient ingested 1.2 g of fluoxetine and subsequently experienced tonic/clonic seizures, symptoms consistent with serotonin syndrome, and rhabdomyolysis, although the patient did not experience sustained renal injury.[A182216]
|
The half life of fluoxetine is significant with the elimination half-life of the parent drug averaging 1-3 days after acute administration, and 4-6 days after chronic administration.[L7664] Further, the elimination half life of it's active metabolite, norfluoxetine, ranges from 4-16 days after both acute and chronic administration.[L7664] The half-life of fluoxetine should be considered when switching patients from fluoxetine to another antidepressant since marked accumulation occurs after chronic use.[L7664] Fluoxetine's long half-life may even be beneficial when discontinuing the drug since the risk of withdrawal is minimized.[L7721]
|
Approximately 94% of fluoxetine is plasma protein bound.[A181673]
|
Fluoxetine is primarily eliminated in the urine.[L8468]
|
The volume of distribution of fluoxetine and it's metabolite varies between 20 to 42 L/kg.[A182216]
|
The clearance value of fluoxetine in healthy patients is reported to be 9.6 ml/min/kg.[A185210]
|
Organic compounds
|
Benzenoids
|
Benzene and substituted derivatives
|
Trifluoromethylbenzenes
|
[
"approved",
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[
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"N",
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"N06",
"N"
] |
[
"Humans and other mammals"
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[
{
"approved": "2005-11-01",
"country": "United States",
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"number": "6960577"
},
{
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},
{
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},
{
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{
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(+-)-N-Methyl-3-phenyl-3-((alpha,alpha,alpha-trifluoro-P-tolyl)oxy)propylamine | (+-)-N-Methyl-gamma-(4-(trifluoromethyl)phenoxy)benzenepropanamine | Fluoxetin | Fluoxetina | Fluoxetine | Fluoxétine | Fluoxetinum | 5HT transporter | 5HTT | HTT | SERT | Solute carrier family 6 member 4 | 5-HT-1C | 5-HT-2C | 5-HT1C | 5-HT2C | 5-HTR2C | 5-hydroxytryptamine receptor 1C | HTR1C | Serotonin receptor 2C | NACHRA3 | CKS-1 | CKS1 | Eag homolog | Eag-related protein 1 | ERG | ERG-1 | ERG1 | Ether-a-go-go-related gene potassium channel 1 | Ether-a-go-go-related protein 1 | H-ERG | HERG | hERG-1 | hERG1 | Potassium voltage-gated channel subfamily H member 2 | Voltage-gated potassium channel subunit Kv11.1 | 1,4-cineole 2-exo-monooxygenase | 1.14.13.- | CYPIIB6 | Cytochrome P450 IIB1 | 1.14.14.1 | CYPIIIA5 | Cytochrome P450-PCN3 | (R)-limonene 6-monooxygenase | (S)-limonene 6-monooxygenase | (S)-limonene 7-monooxygenase | 1.14.14.1 | Cholesterol 25-hydroxylase | CYP2C10 | CYPIIC9 | Cytochrome P-450MP | Cytochrome P450 MP-4 | Cytochrome P450 MP-8 | Cytochrome P450 PB-1 | S-mephenytoin 4-hydroxylase | 1.14.14.- | Cholesterol 25-hydroxylase | CYP2DL1 | CYPIID6 | Cytochrome P450-DB1 | Debrisoquine 4-hydroxylase | CYP2B7 | Cytochrome P450 2B7 short isoform | 1.14.14.1 | Cholesterol 25-hydroxylase | CYPIA2 | Cytochrome P(3)450 | Cytochrome P450 4 | Cytochrome P450-P3 | Hydroperoxy icosatetraenoate dehydratase | 1,4-cineole 2-exo-monooxygenase | 1,8-cineole 2-exo-monooxygenase | 1.14.14.1 | Albendazole monooxygenase (sulfoxide-forming) | Albendazole sulfoxidase | Cholesterol 25-hydroxylase | CYP3A3 | CYPIIIA3 | CYPIIIA4 | Cytochrome P450 3A3 | Cytochrome P450 HLp | Cytochrome P450 NF-25 | Cytochrome P450-PCN1 | Nifedipine oxidase | Quinine 3-monooxygenase | (R)-limonene 6-monooxygenase | (S)-limonene 6-monooxygenase | (S)-limonene 7-monooxygenase | 1.14.14.1 | CYPIIC17 | CYPIIC19 | Cytochrome P450-11A | Cytochrome P450-254C | Fenbendazole monooxygenase (4'-hydroxylating) | Mephenytoin 4-hydroxylase | AGP 1 | AGP1 | OMD 1 | Orosomucoid-1 | ATP-binding cassette sub-family B member 1 | MDR1 | Multidrug resistance protein 1 | P-glycoprotein 1 | PGY1 | Phospholipid transporter ABCB1
|
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"Fluoxetine Hydrochloride",
"Fluoxetine hydrochloride",
"Fluoxetine Hydrochloride",
"Fluoxetine Hydrochloride",
"Fluoxetine Hydrochloride",
"Fluoxetine Hydrochloride",
"Fluoxetine hydrochloride",
"Fluoxetine-10 - Cap",
"Fluoxetine-20 - Cap",
"Fxt 10",
"Fxt 20",
"Fxt 40",
"Gaboxetine",
"Ipg-fluoxetine",
"Ipg-fluoxetine",
"Jamp Fluoxetine Solution",
"Jamp-fluoxetine",
"Jamp-fluoxetine",
"M-fluoxetine",
"M-fluoxetine",
"Mar-fluoxetine",
"Mar-fluoxetine",
"Mint-fluoxetine",
"Mint-fluoxetine",
"Mylan-fluoxetine",
"Mylan-fluoxetine",
"Nra-fluoxetine",
"Nra-fluoxetine",
"Odan-fluoxetine",
"Olanzapine and Fluoxetine",
"Olanzapine and Fluoxetine",
"Olanzapine and Fluoxetine",
"Olanzapine and Fluoxetine",
"Olanzapine and Fluoxetine",
"Olanzapine and Fluoxetine",
"Olanzapine and Fluoxetine",
"Olanzapine and Fluoxetine",
"Olanzapine and Fluoxetine",
"Olanzapine and Fluoxetine",
"Olanzapine and Fluoxetine",
"Olanzapine and Fluoxetine",
"Olanzapine and Fluoxetine",
"Olanzapine and Fluoxetine",
"Olanzapine and Fluoxetine",
"Olanzapine and Fluoxetine",
"Olanzapine and Fluoxetine",
"Olanzapine and Fluoxetine",
"Olanzapine and Fluoxetine",
"Olanzapine and Fluoxetine",
"Penta-fluoxetine Capsules",
"Penta-fluoxetine Capsules",
"PHL-fluoxetine - Cap 10mg",
"PHL-fluoxetine - Cap 20mg",
"PHL-fluoxetine - Solution 20mg/5ml",
"PMS-fluox Capsules 20mg",
"PMS-fluoxetine",
"PMS-fluoxetine",
"PMS-fluoxetine",
"PMS-fluoxetine",
"PMS-fluoxetine Liquid - 20mg/5ml",
"Priva-fluoxetine",
"Priva-fluoxetine",
"Pro-fluoxetine",
"Pro-fluoxetine",
"Prozac",
"Prozac",
"Prozac",
"Prozac",
"Prozac",
"Prozac",
"Prozac",
"Prozac",
"Prozac Capsules 10mg",
"Prozac Capsules 20mg",
"Prozac Liq 20mg/5ml",
"Prozac Weekly",
"Q-fluoxetine",
"Q-fluoxetine",
"Ran-fluoxetine",
"Ran-fluoxetine",
"Ratio-fluoxetine",
"Ratio-fluoxetine",
"Riva-fluoxetine",
"Riva-fluoxetine",
"Riva-fluoxetine",
"Riva-fluoxetine",
"Sandoz Fluoxetine",
"Sandoz Fluoxetine",
"Sandoz Fluoxetine",
"Sandoz Fluoxetine",
"Sarafem",
"Sarafem",
"Sarafem",
"Sarafem",
"Sarafem",
"Sarafem",
"Sarafem",
"Sarafem",
"Selfemra",
"Selfemra",
"Sentraflox AM-10",
"Sentroxatine",
"Stcc-fluoxetine - Cap 10mg",
"Stcc-fluoxetine - Cap 20mg",
"Symbyax",
"Symbyax",
"Symbyax",
"Symbyax",
"Symbyax",
"Teva-fluoxetine",
"Teva-fluoxetine",
"Van-fluoxetine",
"Van-fluoxetine",
"Zym-fluoxetine",
"Zym-fluoxetine"
] |
[
"Adofen",
"Animex-On",
"Fluoxeren",
"Fontex",
"Ladose"
] |
[
"Sentroxatine",
"Gaboxetine",
"Sentraflox AM-10",
"Olanzapine and Fluoxetine",
"Olanzapine and Fluoxetine",
"Olanzapine and Fluoxetine",
"Olanzapine and Fluoxetine",
"Olanzapine and Fluoxetine",
"Olanzapine and Fluoxetine",
"Olanzapine and Fluoxetine",
"Olanzapine and Fluoxetine",
"Olanzapine and Fluoxetine",
"Olanzapine and Fluoxetine",
"Olanzapine and Fluoxetine",
"Olanzapine and Fluoxetine",
"Olanzapine and Fluoxetine",
"Olanzapine and Fluoxetine",
"Olanzapine and Fluoxetine",
"Symbyax",
"Symbyax",
"Symbyax",
"Symbyax",
"Symbyax",
"Olanzapine and Fluoxetine",
"Olanzapine and Fluoxetine",
"Olanzapine and Fluoxetine",
"Olanzapine and Fluoxetine",
"Olanzapine and Fluoxetine"
] |
[
"P31645",
"P28335",
"Q15822",
"P32297",
"P30926",
"P61024",
"Q12809"
] |
[
"P20813",
"P20815",
"P11712",
"P10635",
"Q14097",
"P05177",
"P08684",
"P33261"
] |
[
"P02768",
"P02763"
] |
[
"P08183"
] |
DB06731
|
Seproxetine
|
Seproxetine is also known as (S)-norfluoxetine. It is a selective serotonin reuptake inhibitor (SSRI). It is an active metabolite of fluoxetine. Seproxetine was being investigated by Eli Lilly as an antidepressant but development was never completed and the drug was never marketed.
|
solid
| null | null |
Seproxetine is also known as (S)-norfluoxetine. It is a selective serotonin reuptake inhibitor (SSRI). It is an active metabolite of fluoxetine. Seproxetine was being investigated by Eli Lilly as an antidepressant but development was never completed and the drug was never marketed.
| null | null | null |
4-16 days
| null | null | null | null |
Organic compounds
|
Benzenoids
|
Benzene and substituted derivatives
|
Trifluoromethylbenzenes
|
[
"investigational"
] |
[] |
[] |
[] |
[] |
(S)-norfluoxetine | Seproxetine | NAT1 | NET | NET1 | Norepinephrine transporter | SLC6A5 | Solute carrier family 6 member 2 | 5HT transporter | 5HTT | HTT | SERT | Solute carrier family 6 member 4 | DA transporter | DAT | DAT1 | Solute carrier family 6 member 3 | (R)-limonene 6-monooxygenase | (S)-limonene 6-monooxygenase | (S)-limonene 7-monooxygenase | 1.14.14.1 | Cholesterol 25-hydroxylase | CYP2C10 | CYPIIC9 | Cytochrome P-450MP | Cytochrome P450 MP-4 | Cytochrome P450 MP-8 | Cytochrome P450 PB-1 | S-mephenytoin 4-hydroxylase | (R)-limonene 6-monooxygenase | (S)-limonene 6-monooxygenase | (S)-limonene 7-monooxygenase | 1.14.14.1 | CYPIIC17 | CYPIIC19 | Cytochrome P450-11A | Cytochrome P450-254C | Fenbendazole monooxygenase (4'-hydroxylating) | Mephenytoin 4-hydroxylase | 1,4-cineole 2-exo-monooxygenase | 1,8-cineole 2-exo-monooxygenase | 1.14.14.1 | Albendazole monooxygenase (sulfoxide-forming) | Albendazole sulfoxidase | Cholesterol 25-hydroxylase | CYP3A3 | CYPIIIA3 | CYPIIIA4 | Cytochrome P450 3A3 | Cytochrome P450 HLp | Cytochrome P450 NF-25 | Cytochrome P450-PCN1 | Nifedipine oxidase | Quinine 3-monooxygenase | 1.14.14.1 | CYPIIIA5 | Cytochrome P450-PCN3 | 1.14.14.1 | CYPIIIA7 | Cytochrome P450-HFLA | P450HLp2
|
[] |
[] |
[] |
[
"P23975",
"P31645",
"Q01959"
] |
[
"P11712",
"P33261",
"P08684",
"P20815",
"P24462"
] |
[] |
[] |
DB00647
|
Dextropropoxyphene
|
Dextropropoxyphene is an opioid analgesic manufactured by Eli Lilly and Company. It is used in the symptomatic treatment of mild pain. It displays antitussive and local anaesthetic actions. Due to the risk of cardiac arrhythmias and overdose, possibly leading to death, dextropropoxyphene has been withdrawn from the market in Europe and the United States. The drug is often referred to as the general form, "propoxyphene", however only the dextro-isomer (dextropropoxyphene) has any analgesic effect. The levo-isomer appears to exhibit a very limited antitussive effect.
|
solid
|
For the relief of mild to moderate pain.
|
Propoxyphene, a synthetic opiate agonist, is structurally similar to methadone. Its general pharmacologic properties are those of the opiates as a group. The analgesic effect of propoxyphene is due to the d-isomer, dextropropoxyphene. It binds to the opiate receptors and leads to a decrease of the perception of pain stimuli. Propoxyphene possesses little to no antitussive activity and no antipyretic action.
|
Propoxyphene acts as a weak agonist at OP1, OP2, and OP3 opiate receptors within the central nervous system (CNS). Propoxyphene primarily affects OP3 receptors, which are coupled with G-protein receptors and function as modulators, both positive and negative, of synaptic transmission via G-proteins that activate effector proteins. Binding of the opiate stimulates the exchange of GTP for GDP on the G-protein complex. As the effector system is adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine, and noradrenaline is inhibited. Opioids such as propoxyphene also inhibit the release of vasopressin, somatostatin, insulin, and glucagon. Opioids close N-type voltage-operated calcium channels (OP2-receptor agonist) and open calcium-dependent inwardly rectifying potassium channels (OP3 and OP1 receptor agonist). This results in hyperpolarization and reduced neuronal excitability.
| null |
Hepatic
|
Coma, respiratory depression, circulatory collapse, and pulmonary edema. Seizures occur more frequently in patients with propoxyphene intoxication than in those with opiate intoxication. LD<sub>50</sub>=230mg/kg (orally in rat, Emerson)
|
6-12 hours
| null |
The major route of metabolism is cytochrome CYP3A4 mediated N-demethylation to norpropoxyphene, which is excreted by the kidneys.
In 48 hours, approximately 20% to 25% of the administered dose of propoxyphene is excreted via the urine, most of which is free or conjugated norpropoxyphene.
|
* 16 L/kg
|
* 2.6 L/min
|
Organic compounds
|
Phenylpropanoids and polyketides
|
Stilbenes
| null |
[
"approved",
"illicit",
"investigational",
"withdrawn"
] |
[
"N02AC",
"N02A",
"N02",
"N",
"N02AC",
"N02A",
"N02",
"N",
"N02AC",
"N02A",
"N02",
"N"
] |
[
"Humans and other mammals"
] |
[
{
"cost": "1.32",
"description": "Propoxyphene N-APAP 50-325 mg tablet",
"unit": "tablet"
},
{
"cost": "1.49",
"description": "Darvon 65 mg pulvule",
"unit": "each"
},
{
"cost": "1.6",
"description": "Propoxyphene N-APAP 100-500 mg tablet",
"unit": "tablet"
},
{
"cost": "1.71",
"description": "Darvon 65 mg capsule",
"unit": "capsule"
},
{
"cost": "2.16",
"description": "Darvon-n 100 mg tablet",
"unit": "tablet"
},
{
"cost": "5.33",
"description": "Propoxyphene napsylate powder",
"unit": "g"
},
{
"cost": "0.43",
"description": "Propoxyphene hcl 65 mg capsule",
"unit": "capsule"
},
{
"cost": "0.47",
"description": "Propoxyphene N-APAP 100-650 mg tablet",
"unit": "tablet"
},
{
"cost": "0.57",
"description": "Propoxyphene-APAP 65-650 mg tablet",
"unit": "tablet"
}
] |
[] |
d-Propoxyphene | Destropropossifene | Dextropropoxifeno | Dextropropoxyphen | Dextropropoxyphène | Dextropropoxyphene | Dextropropoxyphenum | Dextroproxifeno | Propoxyphene | hMOP | M-OR-1 | MOP | MOR-1 | MOR1 | Mu opiate receptor | Mu opioid receptor | D-OR-1 | DOR-1 | OPRD | K-OR-1 | KOR-1 | OPRK | ACAT | Acyl-coenzyme A:cholesterol acyltransferase | Brain carboxylesterase hBr1 | Carboxylesterase 1 | CE-1 | CEH | CES2 | Cholesteryl ester hydrolase | Cocaine carboxylesterase | Egasyn | hCE-1 | HMSE | Methylumbelliferyl-acetate deacetylase 1 | Monocyte/macrophage serine esterase | REH | Retinyl ester hydrolase | Serine esterase 1 | SES1 | TGH | Triacylglycerol hydrolase | GluN1 | Glutamate [NMDA] receptor subunit zeta-1 | hNR1 | N-methyl-D-aspartate receptor subunit NR1 | NMD-R1 | NMDAR1 | GluN2A | Glutamate [NMDA] receptor subunit epsilon-1 | hNR2A | N-methyl D-aspartate receptor subtype 2A | NMDAR2A | NR2A | GluN2B | Glutamate [NMDA] receptor subunit epsilon-2 | hNR3 | N-methyl D-aspartate receptor subtype 2B | N-methyl-D-aspartate receptor subunit 3 | NMDAR2B | NR2B | NR3 | GluN2C | Glutamate [NMDA] receptor subunit epsilon-3 | N-methyl D-aspartate receptor subtype 2C | NMDAR2C | NR2C | EB11 | GluN2D | Glutamate [NMDA] receptor subunit epsilon-4 | N-methyl D-aspartate receptor subtype 2D | NMDAR2D | NR2D | GluN3A | KIAA1973 | N-methyl-D-aspartate receptor subtype 3A | NMDAR-L | NMDAR3A | NR3A | GluN3B | N-methyl-D-aspartate receptor subtype 3B | NMDAR3B | NR3B | 1.14.14.- | Cholesterol 25-hydroxylase | CYP2DL1 | CYPIID6 | Cytochrome P450-DB1 | Debrisoquine 4-hydroxylase | 1,4-cineole 2-exo-monooxygenase | 1,8-cineole 2-exo-monooxygenase | 1.14.14.1 | Albendazole monooxygenase (sulfoxide-forming) | Albendazole sulfoxidase | Cholesterol 25-hydroxylase | CYP3A3 | CYPIIIA3 | CYPIIIA4 | Cytochrome P450 3A3 | Cytochrome P450 HLp | Cytochrome P450 NF-25 | Cytochrome P450-PCN1 | Nifedipine oxidase | Quinine 3-monooxygenase | 1,4-cineole 2-exo-monooxygenase | 1,8-cineole 2-exo-monooxygenase | 1.14.14.1 | Albendazole monooxygenase (sulfoxide-forming) | Albendazole sulfoxidase | Cholesterol 25-hydroxylase | CYP3A3 | CYPIIIA3 | CYPIIIA4 | Cytochrome P450 3A3 | Cytochrome P450 HLp | Cytochrome P450 NF-25 | Cytochrome P450-PCN1 | Nifedipine oxidase | Quinine 3-monooxygenase | 1.14.14.1 | 1.14.14.1 | CYPIIIA5 | Cytochrome P450-PCN3 | 1.14.14.1 | CYPIIIA7 | Cytochrome P450-HFLA | P450HLp2 | 2.4.1.17 | HLUG25 | Hyodeoxycholic acid-specific UDPGT | UDPGT 2B4 | UDPGTh-1 | UGT2B11 | UGT2B4
|
[
"642 Tab",
"692 Tab",
"692 Tablet",
"Balacet 325",
"Balacet 325",
"Darvocet A500",
"Darvocet A500",
"Darvocet N100",
"Darvocet-N 100",
"Darvocet-N 50",
"Darvon",
"Darvon N Compound Pulvule 405",
"Darvon-N",
"Darvon-N",
"Darvon-N",
"Darvon-N",
"Novo-propoxyn Cap 65mg",
"Novo-propoxyn Compound Cap",
"Propoxyphene",
"Propoxyphene",
"Propoxyphene",
"Propoxyphene",
"Propoxyphene and Acetaminophen",
"Propoxyphene and Acetaminophen",
"Propoxyphene and Acetaminophen",
"Propoxyphene and Acetaminophen",
"Propoxyphene and Acetaminophen",
"Propoxyphene and Acetaminophen",
"Propoxyphene and Acetaminophen",
"Propoxyphene and Acetaminophen",
"Propoxyphene and Acetaminophen",
"Propoxyphene and Acetaminophen",
"Propoxyphene and Acetaminophen",
"Propoxyphene and Acetaminophen",
"Propoxyphene and Acetaminophen",
"Propoxyphene and Acetaminophen",
"Propoxyphene Hydrochloride",
"Propoxyphene Hydrochloride",
"Propoxyphene Hydrochloride",
"Propoxyphene Hydrochloride",
"Propoxyphene Hydrochloride",
"Propoxyphene Hydrochloride",
"Propoxyphene Hydrochloride",
"Propoxyphene Hydrochloride and Acetaminophen",
"Propoxyphene Hydrochloride and Acetaminophen",
"Propoxyphene Hydrochloride and Acetaminophen",
"Propoxyphene Hydrochloride and Acetaminophen",
"Propoxyphene Hydrochloride and Acetaminophen",
"Propoxyphene Napsylate and Acetaminophen",
"Propoxyphene Napsylate and Acetaminophen",
"Propoxyphene Napsylate and Acetaminophen",
"Propoxyphene Napsylate and Acetaminophen",
"Propoxyphene Napsylate and Acetaminophen",
"Propoxyphene Napsylate and Acetaminophen",
"Propoxyphene Napsylate and Acetaminophen",
"Propoxyphene Napsylate and Acetaminophen",
"Propoxyphene Napsylate and Acetaminophen",
"Propoxyphene Napsylate and Acetaminophen",
"Propoxyphene Napsylate and Acetaminophen",
"Propoxyphene Napsylate and Acetaminophen",
"Propoxyphene Napsylate and Acetaminophen",
"Propoxyphene Napsylate and Acetaminophen",
"Propoxyphene Napsylate and Acetaminophen",
"Propoxyphene Napsylate and Acetaminophen",
"Propoxyphene Napsylate and Acetaminophen",
"Propoxyphene Napsylate and Acetaminophen",
"Propoxyphene Napsylate and Acetaminophen",
"Propoxyphene Napsylate and Acetaminophen",
"Propoxyphene Napsylate and Acetominophen",
"Propoxyphene Napsylate and Acetominophen",
"Propoxyphene Napsylate and Acetominophen",
"Therapoxyphene 650"
] |
[
"Abalgin",
"Dacoton",
"Deprancol",
"Depronal",
"Dolene",
"Doloxene"
] |
[
"Propoxyphene Hydrochloride and Acetaminophen",
"Propoxyphene Napsylate and Acetominophen",
"Propoxyphene Napsylate and Acetominophen",
"Propoxyphene Napsylate and Acetominophen",
"Propoxyphene and Acetaminophen",
"Propoxyphene Napsylate and Acetaminophen",
"Propoxyphene Hydrochloride and Acetaminophen",
"Propoxyphene and Acetaminophen",
"Therapoxyphene 650",
"Propoxyphene Napsylate and Acetaminophen",
"Propoxyphene Napsylate and Acetaminophen",
"Propoxyphene Napsylate and Acetaminophen",
"Propoxyphene and Acetaminophen",
"Propoxyphene Napsylate and Acetaminophen",
"Propoxyphene Napsylate and Acetaminophen",
"Propoxyphene and Acetaminophen",
"Propoxyphene Napsylate and Acetaminophen",
"Darvocet-N 50",
"Darvocet-N 100",
"Darvocet A500",
"Propoxyphene and Acetaminophen",
"Propoxyphene and Acetaminophen",
"Propoxyphene and Acetaminophen",
"Propoxyphene and Acetaminophen",
"Propoxyphene Napsylate and Acetaminophen",
"Propoxyphene Napsylate and Acetaminophen",
"Propoxyphene Hydrochloride and Acetaminophen",
"Propoxyphene Napsylate and Acetaminophen",
"Propoxyphene Napsylate and Acetaminophen",
"Propoxyphene Napsylate and Acetaminophen",
"Propoxyphene Napsylate and Acetaminophen",
"Darvocet N100",
"Darvocet A500",
"Propoxyphene Napsylate and Acetaminophen",
"Propoxyphene Napsylate and Acetaminophen",
"Propoxyphene Napsylate and Acetaminophen",
"Balacet 325",
"Propoxyphene and Acetaminophen",
"Propoxyphene and Acetaminophen",
"Propoxyphene Napsylate and Acetaminophen",
"Propoxyphene Napsylate and Acetaminophen",
"Propoxyphene Hydrochloride and Acetaminophen",
"Propoxyphene Napsylate and Acetaminophen",
"Propoxyphene Napsylate and Acetaminophen",
"Propoxyphene and Acetaminophen",
"Propoxyphene and Acetaminophen",
"Propoxyphene and Acetaminophen",
"Propoxyphene and Acetaminophen",
"Propoxyphene Hydrochloride and Acetaminophen",
"Balacet 325",
"692 Tab",
"Darvon N Compound Pulvule 405",
"Novo-propoxyn Compound Cap",
"692 Tablet"
] |
[
"P35372",
"P41143",
"P41145",
"P23141",
"Q05586",
"Q12879",
"Q13224",
"Q14957",
"O15399",
"Q8TCU5",
"O60391"
] |
[
"P10635",
"P08684",
"P08684",
"Q9HB55",
"P20815",
"P24462",
"P06133"
] |
[] |
[] |
DB00913
|
Anileridine
|
Anileridine is a synthetic opioid and strong analgesic medication. It is a narcotic pain reliever used to treat moderate to severe pain. Narcotic analgesics act in the central nervous system (CNS) to relieve pain. Some of their side effects are also caused by actions in the CNS.
|
solid
|
For treatment and management of pain (systemic) and for use as an anesthesia adjunct.
|
Anileridine, a potent analgesic, is an analog of pethidine. Anileridine is useful for the relief of moderate to severe pain. It may also be used as an analgesic adjunct in general anesthesia in the same manner as meperidine to reduce the amount of anesthetic needed, to facilitate relaxation, and to reduce laryngospasm. In addition, anileridine exerts mild antihistaminic, spasmolytic and antitussive effects. Anileridine's main pharmacologic action is exerted on the CNS. Respiratory depression, when it occurs, is of shorter duration than that seen with morphine or meperidine when equipotent analgesic doses are used.
|
Opiate receptors are coupled with G-protein receptors and function as both positive and negative regulators of synaptic transmission via G-proteins that activate effector proteins. Binding of the opiate stimulates the exchange of GTP for GDP on the G-protein complex. As the effector system is adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine and noradrenaline is inhibited. Opioids also inhibit the release of vasopressin, somatostatin, insulin and glucagon. Opioids such as anileridine close N-type voltage-operated calcium channels (OP2-receptor agonist) and open calcium-dependent inwardly rectifying potassium channels (OP3 and OP1 receptor agonist). This results in hyperpolarization and reduced neuronal excitability.
|
Anileridine is absorbed by all routes of administration.
|
Hepatic
|
Symptoms of overexposure include dizziness, perspiration, a feeling of warmth, dry mouth, visual difficulty, itching, euphoria, restlessness, nervousness and excitement have been reported.
| null |
> 95%
| null | null | null |
Organic compounds
|
Organoheterocyclic compounds
|
Piperidines
|
Phenylpiperidines
|
[
"approved",
"illicit"
] |
[
"N01AH",
"N01A",
"N01",
"N"
] |
[
"Humans and other mammals"
] |
[] |
[] |
1-[2-(4-aminophenyl)ethyl]-4-phenyl-4-piperidinecarboxlic acid ethyl ester | Anileridina | Anileridine | Anileridinum | ethyl 1-(2-(4-aminophenyl)ethyl)-4-phenyl-4-piperidinecarboxylate | ethyl 1-(4-aminophenethyl)-4-phenylisonipecotate | ethyl 1-(p-aminophenethyl)-4-phenylisonipecotate | N-(β-(p-aminophenyl)ethyl)-4-phenyl-4-carbethoxypiperidine | N-β-(p-aminophenyl)ethylnormeperidine | hMOP | M-OR-1 | MOP | MOR-1 | MOR1 | Mu opiate receptor | Mu opioid receptor
|
[
"Leritine Inj 25mg/ml",
"Leritine Tablets 25mg"
] |
[
"Apodol",
"Leritine"
] |
[] |
[
"P35372"
] |
[] |
[] |
[] |
DB01439
|
3-Methylthiofentanyl
|
3-Methyl-thiofentanyl is a [fentanyl] analog and an opioid analgesic that works by inducing central nervous system (CNS) depression.
|
solid
| null | null |
3-Methylthiofentanyl binds to the mu, delta, and kappa opioid receptors. These ultimately lead to decreased pain sensation as well as a number of side effects, such as euphoria, sedation, depressed breathing.
| null | null |
Opioid analgesics are associated with itching, nausea, and potentially serious respiratory depression, which can be life-threatening.
| null | null | null | null | null |
Organic compounds
|
Benzenoids
|
Benzene and substituted derivatives
|
Anilides
|
[
"experimental",
"illicit"
] |
[] |
[
"Humans and other mammals"
] |
[] |
[] |
3-Methyl-thiofentanyl | K-OR-1 | KOR-1 | OPRK | hMOP | M-OR-1 | MOP | MOR-1 | MOR1 | Mu opiate receptor | Mu opioid receptor | D-OR-1 | DOR-1 | OPRD
|
[] |
[] |
[] |
[
"P41145",
"P35372",
"P41143"
] |
[] |
[] |
[] |
DB00504
|
Levallorphan
|
An opioid antagonist with properties similar to those of naloxone; in addition it also possesses some agonist properties. It should be used cautiously; levallorphan reverses severe opioid-induced respiratory depression but may exacerbate respiratory depression such as that induced by alcohol or other non-opioid central depressants. (From Martindale, The Extra Pharmacopoeia, 30th ed, p683)
|
solid
|
For the complete or partial reversal of narcotic depression, including respiratory depression, induced by opioids.
|
Levallorphan, an opioid antagonist similar to naloxone, is used to treat drug overdoses. Levallorphan differs from naloxone in that it also possesses some agonist properties. It is an analogue of levelorphanol that counteracts the actions of narcotic analgesics such as morphine. It is used especially in the treatment of respiratory depression due to narcotic overdoses. Levallorphan prevents or reverses the effects of opioids including respiratory depression, sedation and hypotension. Also, it can reverse the psychotomimetic and dysphoric effects of agonist-antagonists such as pentazocine.
|
Levallorphan antagonizes opioid effects by competing for the same receptor sites. It binds to the opioid mu receptor and the nicotinic acetylcholine receptor alpha2/alpha3.
|
Rapidly absorbed.
|
Hepatic.
|
Oral, rat LD<sub>50</sub>: 109±4 mg/kg
|
1 hour
| null | null | null | null |
Organic compounds
|
Alkaloids and derivatives
|
Morphinans
| null |
[
"approved"
] |
[] |
[
"Humans and other mammals"
] |
[] |
[] |
Levallofano | Levallorphan | Lévallorphane | Levallorphanum | Levalorfano | hMOP | M-OR-1 | MOP | MOR-1 | MOR1 | Mu opiate receptor | Mu opioid receptor
|
[] |
[
"Lorfan"
] |
[] |
[
"Q15822",
"P35372"
] |
[] |
[] |
[] |
DB00369
|
Cidofovir
|
Cidofovir is an injectable antiviral medication employed in the treatment of cytomegalovirus (CMV) retinitis in patients diagnosed with AIDS. It suppresses CMV replication through selective inhibition of viral DNA synthesis.[FDA label] It was manufactured by _Gilead_ and initially approved by the FDA in 1996, but has since been discontinued.[L6223]
|
solid
|
For the treatment of CMV retinitis in patients with acquired immunodeficiency syndrome (AIDS)
|
Cidofovir is a new anti-viral drug. It is classified as a nucleotide analogue and is active against herpes cytomegalovirus (CMV) retinitis infection. Most adults are infected with CMV. Cidofovir suppresses cytomegalovirus (CMV) replication by selective inhibition of viral DNA synthesis.
|
Cidofovir acts through the selective inhibition of viral DNA polymerase.Biochemical data support selective inhibition of CMV DNA polymerase by cidofovir diphosphate, the active intracellular metabolite of cidofovir. Cidofovir diphosphate inhibits herpesvirus polymerases at concentrations that are 8- to 600-fold lower than those needed to inhibit human cellular DNA polymerase alpha, beta, and gamma(1,2,3). Incorporation of cidofovir into the growing viral DNA chain results in reductions in the rate of viral DNA synthesis.
|
100%
| null |
Kidney damage, fall in the number of white blood cells, decreased platelets
|
2.4 to 3.2 hours
|
6%
| null |
* 537 ± 126 mL/kg [VISTIDE ADMINISTERED WITHOUT PROBENECID]
* 410 ± 102 mL/kg [VISTIDE ADMINISTERED WITH PROBENECID]
|
* 179 +/- 23.1 mL/min/1.73 m2 [WITHOUT PROBENECID]
* 148 +/- 38.8 mL/min/1.73 m2 [WITH PROBENECID]
|
Organic compounds
|
Organoheterocyclic compounds
|
Diazines
|
Pyrimidines and pyrimidine derivatives
|
[
"approved"
] |
[
"J05AB",
"J05A",
"J05",
"J"
] |
[
"Human Immunodeficiency Virus"
] |
[
{
"cost": "205.71",
"description": "Vistide 75 mg/ml vial",
"unit": "ml"
},
{
"cost": "923.52",
"description": "Vistide 75 mg/ml Solution 5ml Vial",
"unit": "vial"
}
] |
[
{
"approved": "1992-08-25",
"country": "United States",
"expires": "2010-06-26",
"number": "5142051"
},
{
"approved": "1999-12-21",
"country": "Canada",
"expires": "2016-12-21",
"number": "1340856"
}
] |
({[(S)-1-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3-hydroxypropan-2-yl]oxy}methyl)phosphonic acid | (S)-(3-(4-amino-2-Oxopyrimidin-1(2H)-yl)-1-hydroxypropan-2-yloxy)methylphosphonic acid | (S)-1-(3-Hydroxy-2-phosphonomethoxypropyl)cytosine | (S)-1-[3-Hydroxy-2-(phosphonomethoxy)propyl]cytosine | (S)-1-[3-Hydroxy-2-(phosphonylmethoxy)propyl]cytosine | (S)-HPMPC | [(S)-2-(4-Amino-2-oxo-2H-pyrimidin-1-yl)-1-hydroxymethyl-ethoxymethyl]-phosphonic acid | [[(S)-2-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)ethoxy]methyl]phosphonic acid | 1-(S)-[3-Hydroxy-2-(phosphonomethoxy)propyl]cytosine | 1-[(S)-3-Hydroxy-2-(phosphonomethoxy)propyl]cytosine | CDV | Cidofovir | Cidofovir anhydrous | Cidofovirum | 2.7.7.7 | 2.7.7.7 | HFLF2 | 2.4.2.4 | ECGF1 | Gliostatin | PD-ECGF | Platelet-derived endothelial cell growth factor | TdRPase | TP | hOAT1 | hPAHT | hROAT1 | OAT1 | Organic anion transporter 1 | PAH transporter | PAHT | Renal organic anion transporter 1
|
[
"Cidofovir",
"Cidofovir Dihydrate",
"Mar-cidofovir",
"Vistide",
"Vistide"
] |
[] |
[] |
[] |
[
"P19971"
] |
[] |
[
"Q4U2R8"
] |
DB00370
|
Mirtazapine
|
Mirtazapine is a tetracyclic _piperazino-azepine_ antidepressant agent that was initially approved for the treatment of major depressive disorder (MDD) in the Netherlands in 1994.[A177946] This drug was first manufactured by Organon Inc., and received FDA approval in 1997 for the treatment of major depressive disorder.[T595, L6157] The effects of this drug may be observed as early as 1 week after beginning therapy.[A178144,L6160]
In addition to its beneficial effects in depression, mirtazapine has been reported to be efficacious in the off-label management of various other conditions. It may improve the symptoms of neurological disorders, reverse weight loss caused by medical conditions, improve sleep, and prevent nausea and vomiting after surgery.[A177811]
|
solid
|
This drug is indicated for the treatment of major depressive disorder and its associated symptoms.[FDA label]
Mirtazapine has been used off-label for a variety of conditions including panic disorder, generalized anxiety disorder, dysthymia, tension headaches, hot flushes, post-traumatic stress disorder (PTSD), sleep disorders, substance abuse disorders, and sexual disorders, among others.[A177811,A177946]
|
**General effects and a note on suicidality**
Mirtazapine is effective in treating moderate to severe depression and treats many symptoms normally associated with this condition. These symptoms may include disturbed sleep, lack of appetite, and anhedonia, in addition to anxiety.[A555,A178150,T595]. It is important to note that suicidal ideation and behavior may emerge or increase during treatment with mirtazapine, as with any other antidepressant. This risk is especially pronounced in younger individuals. Patients, medical professionals, and families should monitor for suicidal thoughts, worsening depression, anxiety, agitation, sleep changes, irritable behavior, aggression, impulsivity, restlessness, and other unusual behavior when this drug is taken or the dose is adjusted.[FDA label] Do not administer mirtazapine to children. When deciding to prescribe this drug, carefully consider the increased risk of suicidal thoughts and behavior, especially in young adults.[FDA label]
**Effects on appetite and weight gain**
In addition to the above effects, mirtazapine exerts stimulating effects on appetite, and has been used for increasing appetite and decreasing nausea in cancer patients.[A177952, A177958] Some studies and case reports have shown that this drug improves eating habits and weight gain in patients suffering from anorexia nervosa when administered in conjunction with psychotherapy and/or other psychotropic drugs.[A177961,A178186] In a clinical trial, women with depression experienced a clinically significant mean increase in body weight, fat mass, and concentrations of leptin when treated with mirtazapine for a 6-week period, with a lack of effect on glucose homeostasis.[A177970]
**Effects on sleep**
The use of mirtazapine to treat disordered sleep has been leveraged from its tendency to cause somnolence, which is a frequently experienced adverse effect by patients taking this drug.[A177808,A177994,FDA label] Mirtazapine has been shown to exert beneficial effects on sleep latency, duration, and quality due to its sedating properties.[A177967] Insomnia is a common occurrence in patients with depression, and mirtazapine has been found to be efficacious in treating this condition.[A177808]
|
**Summary**
The mechanism of action of mirtazapine is not fully understood[FDA label] but may be explained by its effects on central adrenergic and serotonergic activity. This drug exhibits a fast onset of action, a high level of response, a manageable side-effect profile, and dual noradrenergic and serotonergic effects that are unique from the effects of other antidepressants.[A177811]
**Effects on various receptors**
It has been shown that both noradrenergic and serotonergic activity increase following mirtazapine administration. The results of these studies demonstrate mirtazapine exerts antagonist activity at presynaptic α2-adrenergic inhibitory autoreceptors and heteroreceptors in the central nervous system. This is thought to lead to enhanced noradrenergic and serotonergic activity [FDA label], which are known to improve the symptoms of depression and form the basis of antidepressant therapy.[A178198, A178201]
Mirtazapine is a strong antagonist of serotonin 5-HT2 and 5-HT3 receptors. It has not been found to bind significantly to the serotonin 5-HT1A and 5-HT1B receptors [FDA label] but indirectly increases 5-HT1A transmission.[A4709]
In addition to the above effects, mirtazapine is a peripheral α1-adrenergic antagonist. This action may explain episodes of orthostatic hypotension that have been reported after mirtazapine use.[FDA label] Mirtazapine is a potent histamine (H1) receptor antagonist, which may contribute to its powerful sedating effects.[FDA label] The pain-relieving effects of mirtazapine may be explained by its effects on opioid receptors.[A13073,A177868]
|
The absorption of this drug is rapid and complete.[A177826, FDA label] Due to first pass metabolism in the liver and metabolism in the gut wall, absolute bioavailability is about 50%.[FDA label,A177826] Peak blood concentrations are attained within about 2 hours after an oral dose. Food has little effect on the absorption of mirtazapine, and no dose adjustment is required if it is taken with food.[FDA label] Steady-state levels are achieved by about 5 days after the initial dose.[FDA label, A177826] Mirtazapine pharmacokinetics vary across gender and age range. Females and the elderly population have been shown to have higher blood concentrations in comparison to males and younger adults.[A177826]
|
Mirtazapine is heavily metabolized in humans.[FDA label] Demethylation and hydroxylation and subsequent glucuronide conjugation are the major pathways by which mirtazapine is metabolized.[A177826,FDA label] Data from in vitro studies on human liver microsomes show that cytochrome 2D6 and 1A2 lead to the formation of the _8-hydroxy metabolite_ of mirtazapine. The CYP3A enzyme metabolizes this drug into its _N-desmethyl and N-oxide_ metabolites. There are various other unconjugated metabolites of this drug that are pharmacologically active, but are measured in the blood at limited concentrations.[FDA label, A177826]
|
**LD50**
Oral LD50 was 830 mg/kg in male Swiss mice 24 hours after being administered mirtazapine.[F4597]
**Overdose information**
Activated charcoal should be administered during an overdose to absorb excess mirtazapine. General supportive therapy should be employed, including maintenance of an adequate airway, oxygen therapy, and ventilation therapy. Vital signs and cardiac rhythm must be monitored. It is not advisable to induce vomiting. Gastric lavage with a large-bore orogastric tube with proper protection of the airway is recommended [FDA label]. There is no antidote for mirtazapine available currently.[FDA label] Consider the possibility of mirtazapine combined with other drugs in an overdose and ensure to contact the local poison control center for guidance on management.[FDA label]
**Carcinogenesis**
At higher than normal doses, mirtazapine increased the incidence of hepatocellular adenomas and carcinomas in male mice. The highest doses administered to the mice were about 20 and 12 times the maximum recommended human dose (MRHD).[FDA label] Hepatocellular tumors and thyroid follicular adenoma/cystadenomas in male rats occurred at an increased rate at a higher mirtazapine dose (60 mg/kg/day). In female rats, both the medium (20 mg/kg/day) and higher (60 mg/kg/day) doses of mirtazapine increased the rate of hepatocellular adenomas.[FDA label] The relevance of these findings in humans is not known at this time.[FDA label]
**Impairment of Fertility**
Mirtazapine was administered to rats at doses reaching 100 mg/kg (equivalent to 20 times the maximum recommended human dose) in a fertility study. There was no impact on mating and conception, however, there was a disturbance of reproductive (estrous) cycling at higher doses. These doses were measured to be at least 3 times the maximum recommended human dose. Loss of fetus before implantation in the uterus occurred when doses equivalent to 20 times the maximum recommended dose were administered.[FDA label]
**Use in pregnancy**
This drug is categorized as a pregnancy category C drug. No adequate studies in pregnant women have been conducted. In rats, an increased rate of post-implantation demise occurred with mirtazapine administration. Additionally, an increase in deaths of rat pups during the first 3 days of lactation with a decrease in pup birth weight was noted. Studies on animals are not always relevant to human response. Mirtazapine should be used during pregnancy only if the clinical need outweighs the possible risks to the fetus.[FDA label]
**Use in nursing**
Whether this drug is excreted in human milk is unknown.[FDA label] Many drugs are found excreted in human breast milk, therefore caution is advised if this drug is used during nursing.[FDA label]
|
20-40 hours [FDA label, A177826]
|
Mirtazapine is about 85% bound to plasma proteins.[A177826,FDA label]
|
This drug is mainly excreted by the kidney. It is 75% eliminated in the urine and 15% eliminated in the feces.[A177826]
|
The volume of distribution after an oral steady-state dose was measured to be 107 ± 42L in a pharmacokinetic study.[L6139]
|
Total body clearance in males was found to be 31 L/h in a clinical pharmacokinetics study after intravenous administration.[A177826]
**Clearance in elderly patients**
Mirtazapine clearance is slower in the elderly than in younger subjects. Exercise caution when this drug is given to elderly patients. In a clinical trial, elderly males showed a marked decrease in mirtazapine clearance when compared to young males taking the same dose. This difference was less significant when clearance was compared between elderly females and younger females taking mirtazapine.[FDA label]
**Clearance in hepatic and renal impairment**
Patients with hepatic and renal impairment have decreased rates of clearance and dosage adjustments may be necessary for these patients.[FDA label] Moderate renal impairment and hepatic impairment cause about a 30% decrease in mirtazapine clearance. Severe renal impairment leads to a 50% decrease in mirtazapine clearance.[A177826]
|
Organic compounds
|
Organoheterocyclic compounds
|
Piperazinoazepines
| null |
[
"approved"
] |
[
"N06AX",
"N06A",
"N06",
"N"
] |
[
"Humans and other mammals"
] |
[
{
"cost": "2.56",
"description": "Mirtazapine 7.5 mg tablet",
"unit": "tablet"
},
{
"cost": "2.77",
"description": "Mirtazapine 15 mg tablet",
"unit": "tablet"
},
{
"cost": "2.85",
"description": "Mirtazapine 30 mg tablet",
"unit": "tablet"
},
{
"cost": "2.91",
"description": "Mirtazapine 45 mg tablet",
"unit": "tablet"
},
{
"cost": "3.26",
"description": "Remeron 15 mg soltab",
"unit": "tablet"
},
{
"cost": "3.47",
"description": "Remeron 30 mg tablet",
"unit": "tablet"
},
{
"cost": "3.55",
"description": "Remeron 30 mg soltab",
"unit": "tablet"
},
{
"cost": "3.57",
"description": "Remeron 45 mg soltab",
"unit": "tablet"
},
{
"cost": "4.42",
"description": "Remeron 15 mg tablet",
"unit": "tablet"
},
{
"cost": "4.61",
"description": "Remeron 45 mg tablet",
"unit": "tablet"
},
{
"cost": "81.02",
"description": "Mirtazapine 30 15 mg Dispersible Tablet Box",
"unit": "box"
},
{
"cost": "83.48",
"description": "Mirtazapine 30 30 mg Dispersible Tablet Box",
"unit": "box"
},
{
"cost": "88.95",
"description": "Mirtazapine 30 45 mg Dispersible Tablet Box",
"unit": "box"
},
{
"cost": "107.27",
"description": "Remeron SolTab 30 30 mg Dispersible Tablet Box",
"unit": "box"
},
{
"cost": "107.58",
"description": "Remeron SolTab 30 15 mg Dispersible Tablet Box",
"unit": "box"
},
{
"cost": "114.4",
"description": "Remeron SolTab 30 45 mg Dispersible Tablet Box",
"unit": "box"
},
{
"cost": "0.39",
"description": "Pms-Mirtazapine 15 mg Tablet",
"unit": "tablet"
},
{
"cost": "0.73",
"description": "Apo-Mirtazapine 30 mg Tablet",
"unit": "tablet"
},
{
"cost": "0.73",
"description": "Mylan-Mirtazapine 30 mg Tablet",
"unit": "tablet"
},
{
"cost": "0.73",
"description": "Novo-Mirtazapine 30 mg Tablet",
"unit": "tablet"
},
{
"cost": "0.73",
"description": "Phl-Mirtazapine 30 mg Tablet",
"unit": "tablet"
},
{
"cost": "0.73",
"description": "Pms-Mirtazapine 30 mg Tablet",
"unit": "tablet"
},
{
"cost": "0.73",
"description": "Ratio-Mirtazapine 30 mg Tablet",
"unit": "tablet"
},
{
"cost": "0.73",
"description": "Sandoz Mirtazapine 30 mg Tablet",
"unit": "tablet"
}
] |
[
{
"approved": "1993-01-12",
"country": "United States",
"expires": "2010-01-12",
"number": "5178878"
},
{
"approved": "2010-06-08",
"country": "Canada",
"expires": "2020-10-09",
"number": "2386547"
}
] |
1,2,3,4,10,14b-Hexahydro-2-methylpyrazino(2,1-a)pyrido(2,3-c)benzazepine | 6-Azamianserin | Mepirzapine | Mirtazapin | Mirtazapina | Mirtazapine | Mirtazapinum | 5-HT-2 | 5-HT-2A | HTR2 | Serotonin receptor 2A | ADRA2R | ADRAR | Alpha-2 adrenergic receptor subtype C10 | Alpha-2A adrenoceptor | Alpha-2A adrenoreceptor | Alpha-2AAR | 5-HT-1C | 5-HT-2C | 5-HT1C | 5-HT2C | 5-HTR2C | 5-hydroxytryptamine receptor 1C | HTR1C | Serotonin receptor 2C | ADRA1C | Alpha-1A adrenoceptor | Alpha-1A adrenoreceptor | Alpha-1C adrenergic receptor | Alpha-adrenergic receptor 1c | Alpha-1B adrenoceptor | Alpha-1B adrenoreceptor | ADRA1A | Alpha-1A adrenergic receptor | Alpha-1D adrenoceptor | Alpha-1D adrenoreceptor | Alpha-adrenergic receptor 1a | K-OR-1 | KOR-1 | OPRK | H1-R | H1R | HH1R | 1,4-cineole 2-exo-monooxygenase | 1,8-cineole 2-exo-monooxygenase | 1.14.14.1 | Albendazole monooxygenase (sulfoxide-forming) | Albendazole sulfoxidase | Cholesterol 25-hydroxylase | CYP3A3 | CYPIIIA3 | CYPIIIA4 | Cytochrome P450 3A3 | Cytochrome P450 HLp | Cytochrome P450 NF-25 | Cytochrome P450-PCN1 | Nifedipine oxidase | Quinine 3-monooxygenase | 1.14.14.- | Cholesterol 25-hydroxylase | CYP2DL1 | CYPIID6 | Cytochrome P450-DB1 | Debrisoquine 4-hydroxylase | 1.14.14.1 | Cholesterol 25-hydroxylase | CYPIA2 | Cytochrome P(3)450 | Cytochrome P450 4 | Cytochrome P450-P3 | Hydroperoxy icosatetraenoate dehydratase | 5HT transporter | 5HTT | HTT | SERT | Solute carrier family 6 member 4
|
[
"Apo-mirtazapine",
"Apo-mirtazapine",
"Apo-mirtazapine",
"Auro-mirtazapine",
"Auro-mirtazapine",
"Auro-mirtazapine",
"Auro-mirtazapine OD",
"Auro-mirtazapine OD",
"Auro-mirtazapine OD",
"Ava-mirtazapine",
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"Co Mirtazapine",
"Dom-mirtazapine",
"Dom-mirtazapine",
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"Gd-mirtazapine OD",
"Gd-mirtazapine OD",
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"Mirtazapine",
"Mirtazapine",
"Mirtazapine",
"Mirtazapine",
"Mirtazapine",
"Mirtazapine",
"Mirtazapine",
"Mirtazapine",
"Mirtazapine",
"Mirtazapine",
"Mirtazapine",
"Mirtazapine",
"Mirtazapine",
"Mirtazapine",
"Mirtazapine",
"Mirtazapine",
"Mirtazapine",
"Mirtazapine",
"Mirtazapine",
"Mirtazapine",
"Mirtazapine",
"Mirtazapine",
"Mirtazapine",
"Mirtazapine",
"Mirtazapine",
"Mirtazapine",
"Mirtazapine",
"Mirtazapine",
"Mirtazapine",
"Mirtazapine",
"Mirtazapine",
"Mirtazapine",
"Mirtazapine",
"Mirtazapine",
"Mirtazapine",
"Mirtazapine",
"Mirtazapine",
"Mirtazapine",
"Mirtazapine",
"Mirtazapine",
"Mirtazapine",
"Mirtazapine",
"Mirtazapine",
"Mirtazapine",
"Mirtazapine - 15",
"Mirtazapine - 30",
"Mirtazapine - 45",
"Mylan-mirtazapine",
"Mylan-mirtazapine",
"Mylan-mirtazapine",
"Nra-mirtazapine",
"Nra-mirtazapine",
"Nra-mirtazapine",
"Ntp-mirtazapine",
"Ntp-mirtazapine Od Tablets",
"Ntp-mirtazapine Od Tablets",
"Ntp-mirtazapine Od Tablets",
"Nu-mirtazapine",
"Nu-mirtazapine",
"Nu-mirtazapine",
"PMS-mirtazapine",
"PMS-mirtazapine",
"Pro-mirtazapine",
"Pro-mirtazapine",
"Pro-mirtazapine",
"Ratio-mirtazapine",
"Remeron",
"Remeron",
"Remeron",
"Remeron",
"Remeron",
"Remeron",
"Remeron",
"Remeron",
"Remeron",
"Remeron",
"Remeron",
"Remeron",
"Remeron",
"Remeron Rd",
"Remeron Rd",
"Remeron Rd",
"Remeron Soltab",
"Remeron Soltab",
"Remeronsoltab",
"Remeronsoltab",
"Remeronsoltab",
"Remeronsoltab",
"Remeronsoltab",
"Remeronsoltab",
"Riva-mirtazapine",
"Sandoz Mirtazapine",
"Sandoz Mirtazapine",
"Sandoz Mirtazapine Fc",
"Teva-mirtazapine",
"Teva-mirtazapine",
"Teva-mirtazapine",
"Teva-mirtazapine OD",
"Teva-mirtazapine OD",
"Teva-mirtazapine OD",
"Zym-mirtazapine",
"Zym-mirtazapine"
] |
[
"Avanza",
"Axit",
"Mirtabene",
"Mirtaz",
"Mirtazon",
"Norset",
"Promyrtil",
"Remergil",
"Remergon",
"Rexer",
"Zispin"
] |
[] |
[
"P28223",
"Q9UE69",
"P08913",
"P28335",
"P35348",
"P35368",
"P25100",
"P41145",
"P35367"
] |
[
"P08684",
"P10635",
"P05177"
] |
[] |
[
"P31645"
] |
DB00371
|
Meprobamate
|
A carbamate with hypnotic, sedative, and some muscle relaxant properties, although in therapeutic doses reduction of anxiety rather than a direct effect may be responsible for muscle relaxation. Meprobamate has been reported to have anticonvulsant actions against petit mal seizures, but not against grand mal seizures (which may be exacerbated). It is used in the treatment of anxiety disorders, and also for the short-term management of insomnia but has largely been superseded by the benzodiazepines. (From Martindale, The Extra Pharmacopoeia, 30th ed, p603) Meprobamate is a controlled substance in the U.S.
|
solid
|
For the management of anxiety disorders or for the short-term relief of the symptoms of anxiety.
|
Meprobamate is an anxiolytic drug. It was the best selling minor tranquilizer for a time but has largely been replaced by benzodiazepines. Meprobamate has most of the pharmacological effects and dangers of the barbiturates (though it was marketed as being safer) but it is less sedating at effective doses. Meprobamate exhibits some anticonvulsant effects in absence seizures; however, it is reported to potentially exacerbate generalized tonic-clonic seizures. It has also been used as a hypnotic (sleeping pill). However, its is currently only licensed as an anxiolytic and it is a third or fourth-order choice.
|
Meprobamate's mechanism of action is not fully understood; in animal studies, meprobamate is reported to act at multiple sites in the central nervous system, such as the thalamus and limbic system. It binds to the GABA<sub>A</sub> receptors, leading to inhibitory effects on the neurons transmitting signals in the reticular formation and spinal cord. Consequently, effects such as sedation and altered perception of pain are observed.
|
Well absorbed from the gastrointestinal tract.
|
Meprobamate undergoes hepatic metabolism.
|
Symptoms of overdose include coma, drowsiness, loss of muscle control, severely impaired breathing, shock, sluggishness, and unresponsiveness. There have been a case of death resulting from oral ingestion of 12 g of meprobamate. One case study reports the consumption of 40 g of meprobamate resulting in successful survival.
|
Plasma half-life is about 10 hours.
| null | null | null | null |
Organic compounds
|
Organic acids and derivatives
|
Carboxylic acids and derivatives
|
Amino acids, peptides, and analogues
|
[
"approved",
"illicit"
] |
[
"N05BC",
"N05B",
"N05",
"N",
"N05CX",
"N05C",
"N05",
"N",
"N05BC",
"N05B",
"N05",
"N"
] |
[
"Humans and other mammals"
] |
[
{
"cost": "1.42",
"description": "Meprobamate 200 mg tablet",
"unit": "tablet"
},
{
"cost": "4.95",
"description": "Mepron 750 mg/5 ml suspension",
"unit": "ml"
},
{
"cost": "5.41",
"description": "Mepron 750 mg/5ml Suspension",
"unit": "ml"
},
{
"cost": "0.78",
"description": "Meprozine 50-25 mg capsule",
"unit": "capsule"
},
{
"cost": "0.84",
"description": "Meprobamate 400 mg tablet",
"unit": "tablet"
}
] |
[
{
"approved": "2003-11-18",
"country": "United States",
"expires": "2017-01-10",
"number": "6649659"
},
{
"approved": "1991-01-01",
"country": "United States",
"expires": "2009-08-15",
"number": "4981874"
},
{
"approved": "2001-10-16",
"country": "Canada",
"expires": "2013-12-23",
"number": "2152615"
},
{
"approved": "1995-07-11",
"country": "Canada",
"expires": "2012-07-11",
"number": "1336266"
}
] |
Meprobamat | Meprobamate | Meprobamato | Meprobamatum | Meprobamic acid | 3.5.1.88 | PDF1A | Polypeptide deformylase | 2.7.11.13 | nPKC-epsilon | PKCE | GABA(A) receptor subunit alpha-1 | GABAAR subunit alpha-1 | GABA(A) receptor subunit alpha-2 | GABAAR subunit alpha-2 | GABA(A) receptor subunit alpha-3 | GABAAR subunit alpha-3 | GABA(A) receptor subunit alpha-4 | GABAAR subunit alpha-4 | GABA(A) receptor subunit alpha-5 | GABAAR subunit alpha-5 | GABA(A) receptor subunit alpha-6 | GABAAR subunit alpha-6 | GABA(A) receptor subunit beta-1 | GABAAR subunit beta-1 | GABA(A) receptor subunit beta-2 | GABAAR subunit beta-2 | GABA(A) receptor subunit beta-3 | GABAAR subunit beta-3 | GABA(A) receptor subunit delta | GABAAR subunit delta | GABA(A) receptor subunit epsilon | GABAAR subunit epsilon | GABA(A) receptor subunit gamma-1 | GABAAR subunit gamma-1 | GABA(A) receptor subunit gamma-2 | GABAAR subunit gamma-2 | GABA(A) receptor subunit gamma-3 | GABAAR subunit gamma-3 | GABA(A) receptor subunit pi | GABAAR subunit pi | GABA(A) receptor subunit theta | GABAAR subunit theta | GABA(A) receptor subunit alpha-1 | GABAAR subunit alpha-1 | GABA(A) receptor subunit alpha-2 | GABAAR subunit alpha-2 | GABA(A) receptor subunit alpha-3 | GABAAR subunit alpha-3 | GABA(A) receptor subunit alpha-4 | GABAAR subunit alpha-4 | GABA(A) receptor subunit alpha-5 | GABAAR subunit alpha-5 | GABA(A) receptor subunit alpha-6 | GABAAR subunit alpha-6
|
[
"282 Mep Tab",
"Apo Meprobamate Tab 400mg",
"Equagesic",
"Equagesic Tablets",
"Equanil Tablets 400mg",
"Meditran 400mg",
"Meprobamate",
"Meprobamate",
"Meprobamate",
"Meprobamate",
"Meprobamate",
"Meprobamate",
"Meprobamate",
"Meprobamate",
"Meprobamate",
"Meprobamate",
"Meprobamate",
"Meprobamate",
"Meprobamate",
"Meprobamate",
"Meprobamate",
"Meprobamate",
"Meprobamate",
"Meprobamate Tab 400mg",
"Meprobamate Tab 400mg",
"Novo-mepro 200mg",
"Novo-mepro 400mg"
] |
[
"Equanil",
"Meprospan",
"Miltown"
] |
[
"Equagesic",
"282 Mep Tab",
"Equagesic Tablets"
] |
[
"Q9HBH1",
"Q02156",
"P14867",
"P47869",
"P34903",
"P48169",
"P31644",
"Q16445",
"P18505",
"P47870",
"P28472",
"O14764",
"P78334",
"Q8N1C3",
"P18507",
"Q99928",
"O00591",
"Q9UN88",
"P14867",
"P47869",
"P34903",
"P48169",
"P31644",
"Q16445"
] |
[] |
[] |
[] |
DB00544
|
Fluorouracil
|
A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the thymidylate synthetase conversion of deoxyuridylic acid to thymidylic acid.
|
solid
|
For the topical treatment of multiple actinic or solar keratoses. In the 5% strength it is also useful in the treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites. Fluorouracil injection is indicated in the palliative management of some types of cancer, including colon, esophageal, gastric, rectum, breast, biliary tract, stomach, head and neck, cervical, pancreas, renal cell, and carcinoid.
|
Fluorouracil is an antineoplastic anti-metabolite. Anti-metabolites masquerade as purine or pyrimidine - which become the building blocks of DNA. They prevent these substances from becoming incorporated into DNA during the "S" phase (of the cell cycle), stopping normal development and division. Fluorouracil blocks an enzyme which converts the cytosine nucleotide into the deoxy derivative. In addition, DNA synthesis is further inhibited because Fluorouracil blocks the incorporation of the thymidine nucleotide into the DNA strand.
|
The precise mechanism of action has not been fully determined, but the main mechanism of fluorouracil is thought to be the binding of the deoxyribonucleotide of the drug (FdUMP) and the folate cofactor, N5–10-methylenetetrahydrofolate, to thymidylate synthase (TS) to form a covalently bound ternary complex. This results in the inhibition of the formation of thymidylate from uracil, which leads to the inhibition of DNA and RNA synthesis and cell death. Fluorouracil can also be incorporated into RNA in place of uridine triphosphate (UTP), producing a fraudulent RNA and interfering with RNA processing and protein synthesis.
|
28-100%
|
Hepatic. The catabolic metabolism of fluorouracil results in degradation products ( e.g., CO2, urea and α-fluoro-ß-alanine) which are inactive.
|
LD<sub>50</sub>=230mg/kg (orally in mice)
|
10-20 minutes
|
8-12%
|
Seven percent to 20% of the parent drug is excreted unchanged in the urine in 6 hours; of this over 90% is excreted in the first hour.
The remaining percentage of the administered dose is metabolized, primarily in the liver.
| null | null |
Organic compounds
|
Organoheterocyclic compounds
|
Diazines
|
Pyrimidines and pyrimidine derivatives
|
[
"approved"
] |
[
"L01BC",
"L01B",
"L01",
"L",
"L01BC",
"L01B",
"L01",
"L"
] |
[
"Humans and other mammals"
] |
[
{
"cost": "6.43",
"description": "Carac cream",
"unit": "g"
},
{
"cost": "7.85",
"description": "Fluoroplex 1% cream",
"unit": "g"
},
{
"cost": "8.45",
"description": "Fluorouracil powder",
"unit": "g"
},
{
"cost": "9.62",
"description": "Fluorouracil 5% cream",
"unit": "g"
},
{
"cost": "10.28",
"description": "Efudex 5% cream",
"unit": "g"
},
{
"cost": "78.63",
"description": "Fluorouracil 2% Solution 10ml Bottle",
"unit": "bottle"
},
{
"cost": "115.78",
"description": "Fluorouracil 5% Solution 10ml Bottle",
"unit": "bottle"
},
{
"cost": "136.51",
"description": "Efudex 5% Solution 10ml Bottle",
"unit": "bottle"
},
{
"cost": "209.77",
"description": "Carac 0.5% Cream 30 gm Tube",
"unit": "tube"
},
{
"cost": "249.98",
"description": "Fluorouracil 5% Cream 40 gm Tube",
"unit": "tube"
},
{
"cost": "268.61",
"description": "Fluoroplex 1% Cream 30 gm Tube",
"unit": "tube"
},
{
"cost": "478.39",
"description": "Efudex 5% Cream 40 gm Tube",
"unit": "tube"
},
{
"cost": "0.28",
"description": "Fluorouracil 5000 mg/100 ml",
"unit": "ml"
},
{
"cost": "0.4",
"description": "Adrucil 50 mg/ml vial",
"unit": "ml"
},
{
"cost": "0.52",
"description": "Fluorouracil 50 mg/ml Solution",
"unit": "ml"
},
{
"cost": "0.9",
"description": "Efudex 50 mg/g Cream",
"unit": "g"
}
] |
[
{
"approved": "2003-12-30",
"country": "United States",
"expires": "2021-06-02",
"number": "6670335"
},
{
"approved": "2007-01-30",
"country": "United States",
"expires": "2023-07-18",
"number": "7169401"
}
] |
5-Fluoracil | 5-Fluoropyrimidine-2,4-dione | 5-Fluorouracil | 5-Fluracil | 5-FU | Fluoro Uracil | Fluorouracil | Fluorouracilo | Fluorouracilum | Fluouracil | 2.7.7.49 | EST2 | HEST2 | TCS1 | Telomerase catalytic subunit | Telomerase-associated protein 2 | TP2 | TRT | 1.3.1.2 | DHPDHase | Dihydrothymine dehydrogenase | Dihydrouracil dehydrogenase | DPD | 2.1.1.45 | CDC21 | TS | TSA1 | 2.1.1.45 | TS | TSase | 1.3.1.2 | DHPDHase | Dihydrothymine dehydrogenase | Dihydrouracil dehydrogenase | DPD | 2.4.2.3 | UP | UPase 1 | UrdPase 1 | 2.4.2.3 | UPase 2 | UrdPase 2 | 1,4-cineole 2-exo-monooxygenase | 1.14.14.- | Coumarin 7-hydroxylase | CYP2A3 | CYPIIA6 | Cytochrome P450 IIA3 | Cytochrome P450(I) | 1.14.14.1 | CYPIIC8 | Cytochrome P450 form 1 | Cytochrome P450 IIC2 | Cytochrome P450 MP-12 | Cytochrome P450 MP-20 | S-mephenytoin 4-hydroxylase | 1.5.1.53 | 2.1.1.45 | TS | TSase | UMP synthase | 2.4.2.14 | ATase | Glutamine phosphoribosylpyrophosphate amidotransferase | GPAT | 1.14.14.1 | Cholesterol 25-hydroxylase | CYPIA2 | Cytochrome P(3)450 | Cytochrome P450 4 | Cytochrome P450-P3 | Hydroperoxy icosatetraenoate dehydratase | 2.4.2.4 | ECGF1 | Gliostatin | PD-ECGF | Platelet-derived endothelial cell growth factor | TdRPase | TP | (R)-limonene 6-monooxygenase | (S)-limonene 6-monooxygenase | (S)-limonene 7-monooxygenase | 1.14.14.1 | Cholesterol 25-hydroxylase | CYP2C10 | CYPIIC9 | Cytochrome P-450MP | Cytochrome P450 MP-4 | Cytochrome P450 MP-8 | Cytochrome P450 PB-1 | S-mephenytoin 4-hydroxylase | Serpin A7 | T4-binding globulin | TBG | hOAT2 | NLT | Novel liver transporter | OAT2 | Organic anion transporter 2 | ENT1 | Equilibrative NBMPR-sensitive nucleoside transporter | Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter | es nucleoside transporter | hENT1 | Nucleoside transporter, es-type | Solute carrier family 29 member 1 | 7.6.2.2 | ABCP | ATP-binding cassette sub-family G member 2 | BCRP | BCRP1 | Breast cancer resistance protein | CDw338 | Mitoxantrone resistance-associated protein | MXR | Placenta-specific ATP-binding cassette transporter | Urate exporter | 7.6.2.- | 7.6.2.2 | 7.6.2.3 | Canalicular multispecific organic anion transporter 2 | CMOAT2 | MLP2 | MOAT-D | MRP3 | Multi-specific organic anion transporter D | Multidrug resistance-associated protein 3 | 7.6.2.- | 7.6.2.2 | 7.6.2.3 | MOAT-B | MOATB | MRP/cMOAT-related ABC transporter | MRP4 | Multi-specific organic anion transporter B | Multidrug resistance-associated protein 4 | 7.6.2.- | 7.6.2.2 | MOAT-C | MRP5 | Multi-specific organic anion transporter C | Multidrug resistance-associated protein 5 | pABC11 | SMRP
|
[
"Actikerall",
"Adrucil",
"Adrucil",
"Adrucil",
"Adrucil",
"Adrucil Inj 50mg/ml",
"Carac",
"Carac",
"Efudex",
"Efudex",
"Efudex",
"Efudex",
"Efudex",
"Fluorac",
"Fluoroplex",
"Fluoroplex",
"Fluoroplex Cream 1%",
"Fluorouracil",
"Fluorouracil",
"Fluorouracil",
"Fluorouracil",
"Fluorouracil",
"Fluorouracil",
"Fluorouracil",
"Fluorouracil",
"Fluorouracil",
"Fluorouracil",
"Fluorouracil",
"Fluorouracil",
"Fluorouracil",
"Fluorouracil",
"Fluorouracil",
"Fluorouracil",
"Fluorouracil",
"Fluorouracil",
"Fluorouracil",
"Fluorouracil",
"Fluorouracil",
"Fluorouracil",
"Fluorouracil",
"Fluorouracil",
"Fluorouracil",
"Fluorouracil",
"Fluorouracil",
"Fluorouracil",
"Fluorouracil",
"Fluorouracil",
"Fluorouracil",
"Fluorouracil",
"Fluorouracil",
"Fluorouracil",
"Fluorouracil",
"Fluorouracil",
"Fluorouracil",
"Fluorouracil",
"Fluorouracil",
"Fluorouracil",
"Fluorouracil",
"Fluorouracil",
"Fluorouracil",
"Fluorouracil",
"Fluorouracil",
"Fluorouracil",
"Fluorouracil",
"Fluorouracil",
"Fluorouracil",
"Fluorouracil",
"Fluorouracil",
"Fluorouracil",
"Fluorouracil",
"Fluorouracil",
"Fluorouracil",
"Fluorouracil",
"Fluorouracil",
"Fluorouracil",
"Fluorouracil",
"Fluorouracil",
"Fluorouracil",
"Fluorouracil Cream",
"Fluorouracil Inj 50mg/ml",
"Fluorouracil Injection",
"Fluorouracil Injection",
"Fluorouracil Injection",
"Fluorouracil Injection",
"Fluorouracil Injection",
"Fluorouracil Injection",
"Fluorouracil Injection",
"Fluorouracil Injection USP",
"Fluorouracil Injection USP",
"Tolak",
"Tolak",
"Tolak",
"Verrunex"
] |
[
"Carzonal",
"Efudix",
"Efurix",
"Ftoruracil"
] |
[
"Verrunex",
"Fluorac",
"Actikerall"
] |
[
"O14746",
"Q12882",
"P04818"
] |
[
"Q12882",
"Q16831",
"O95045",
"P11509",
"P10632",
"P42898",
"P04818",
"P11172",
"Q06203",
"P05177",
"P19971",
"P11712"
] |
[
"P02768",
"P05543"
] |
[
"Q9Y694",
"Q99808",
"Q9UNQ0",
"O15438",
"O15439",
"O15440"
] |
DB01101
|
Capecitabine
|
Capecitabine is an orally-administered chemotherapeutic agent used in the treatment of metastatic breast and colorectal cancers. Capecitabine is a prodrug, that is enzymatically converted to fluorouracil (antimetabolite) in the tumor, where it inhibits DNA synthesis and slows growth of tumor tissue.
|
solid
|
Capecitabine is indicated as treatment for a variety of cancer types. For colorectal cancer, capecitabine is indicated as a single agent or a component of a combination chemotherapy regiment for the adjuvant treatment of stage III colon cancer and treatment unresectable or metastatic colorectal cancer. It can also be used as a part of a combination chemotherapy perioperative treatment of adult locally advanced rectal cancer.[L44657] For breast cancer, capecitabine is indicated for advanced or metastatic breast cancer as a single agent if an anthracycline- or taxane-containing chemotherapy is not indicated or as a regimen with docetaxel after disease progression on prior anthracycline-containing chemotherapy.[L44657] For gastric, esophageal, or gastroesophageal junction (GEJ) cancer, capecitabine is indicated as a component of a combination chemotherapy treatment for the treatment of adult unresectable or metastatic gastric, esophageal, or GEJ cancer or adult HER2-overexpressing metastatic gastric or GEJ adenocarcinoma who have not received prior treatment for metastatic disease.[L44657] Finally, for pancreatic cancer, capecitabine is indicated as adjuvant treatment for adult pancreatic adenocarcinoma as a component of a combination chemotherapy regimen.[L44657]
|
Capecitabine is a fluoropyrimidine carbamate belonging to a group of antineoplastic agents called antimetabolites, which kill cancerous cells by interfering with DNA synthesis.[A256242,A841] It is an orally administered systemic prodrug that has little pharmacologic activity until it is converted to 5-fluorouracil (5-FU) by enzymes that are expressed in higher concentrations in many tumors.[A256247] Capecitabine was designed specifically to overcome the disadvantages of 5-FU and to mimic the infusional pharmacokinetics of 5-FU without the associated complexity and complications of central venous access and infusion pumps.[A256242] Particularly, since the enzymes converting 5-FU into active metabolites exist in the gastrointestinal tract, infusion of 5-FU can have gastrointestinal toxicity while also losing efficacy.[A256252] Since capecitabine can be transported intact across the intestinal mucosa, it can be selectively delivered 5-FU to tumor tissues through enzymatic conversion preferentially inside tumor cells.[A256252]
5-FU exerts its pharmacological action through the inhibition and interference of 3 main targets: thymidylate synthase, DNA, and RNA, leading through protein synthesis disruption and apoptosis.[A841,A256152] Population-based exposure-effect analyses demonstrated a positive association between AUC of 5-FU and grade 3-4 hyperbilirubinemia.[L44657]
|
Capecitabine is metabolized to 5-fluorouracil in vivo by carboxylesterases, cytidine deaminase, and thymidine phosphorylase/uridine phosphorylase sequentially.[L44657,A256027,A256142,A256147,A32078] 5-fluorouracil is further metabolized through a series of enzymatic reactions into 3 main active metabolites: 5-fluorouridine triphosphate (5-FUTP), 5-fluoro-2’-deoxyuridine monophosphate (5-FdUMP), and 5-fluorodeoxyuridine triphosphate (5-FdUTP).[A256062,A256027,A256077]. These metabolites cause cell injury by two different mechanisms. First, FdUMP and the folate cofactor, N5-10-methylenetetrahydrofolate (CH<sub>2</sub>THF), bind to thymidylate synthase (TS) to form a covalently bound ternary complex.[L44657] TS is an enzyme that catalyzes the methylation of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP).[A256152,A256077] Under normal physiological conditions, dUMP binds to TS first before CH<sub>2</sub>THF, followed by a 1,4 or Michael addition from the pyrimidine C (6)atom to the Cys146 nucleophile.[A256152,A256157] If correctly positioned, dUMP, CH<sub>2</sub>THF, and TS would form a ternary complex to facilitate the donation of the methyl group from CH<sub>2</sub>THF to dUMP.[A256152] However, the substitution of dUMP with FdUMP results in a new time-dependent TS–FdUMP–CH2THF complex. Since the fluorine group prevents dissociation of FdUMP from the pyrimidine ring, the whole complex is rendered irreversibly deactivated, terming this reaction "suicide inhibition".[A256152,A256162] TS inhibition prevents the conversion of dUMP to dTMP, depleting the pool of dTMP that could be phosphorylated into dTTP to be incorporated as DNA nucleotides. This disrupts the nucleotides balance, particularly the the ATP/dTTP ratio, thus impairing DNA synthesis and repair and causing apoptosis.[A256167,A256152]
5-FdUMP can also be phosphorylated into 5-FdUTP, further increasing the pool of dUTP base to potentially overwhelm the activity of dUTPase.[A256177] Coupled with the decrease in dTTP, 5-FdUMP, and 5-FdUTP increase the probability of mistakenly incorporating a uracil base into DNA strands in place of thymine. Although this mistake can often be resolved by the nucleotide excision repair enzyme uracil-DNA-glycosylase (UDG), the high (F)dUTP/dTTP ratio would result in re-incorporation of uracil into DNA, leading to a futile cycle of misincorporation, excision, and repair.[A256172,A841] Repeated base excision repair can result in abasic sites, which can lead to DNA mutagenesis and thus protein miscoding, replication forks collapse, and DNA fragmentation through single or double strand breaks [A256177,A256182,A256187,A256192]
However, several reports have found that the incorporation of uracil in genomic DNA does not significantly affect the cytotoxicity of 5-FU, suggesting that the cytotoxic effect of 5-FU is dominated by the perturbation of RNA through 5-FUTP.[A256197,A256202] Similar to 5-dFUTP, 5-FUTP can be mistakenly incorporated into RNA in place of regular UTP and disrupt regular RNA biology through various mechanisms. 5-FUTP can be incorporated into the spliceosomal U2 snRNA at pseudouridylated sites to prevent further pseudouridylation and thus pre-mrNA splicing. 5-FUTP can also change the structure of U4 and U6 snRNA and reduce the turnover rate of U1 snrNA once incorporated.[A256207] For tRNA, 5-FUTP can affect tRNA's post-transcriptional RNA modifications activity, particularly by inhbiting pseudouridine synthase through formation of covalent complex.[A256212,A256217] Recently, the effect of 5-FUTP on miRNAs and lncRNA was also observed through profound changes in expression, although the precise mechanism is still unknown.[A256222,A256227,A256232]
Although the main mechanism of 5-FU cytotoxicity was thought to be attributed to DNA damages, recent reports have shown that the majority of 5-FU pharmacological action is mediated through RNA, since 5-FU is accumulated ~3000- to 15 000-fold more in RNA compared to that of DNA.[A256237]
|
The AUC of capecitabine and its metabolite 5’-DFCR increases proportionally over a dosage range of 500 mg/m2/day to 3,500 mg/m2/day (0.2 to 1.4 times the approved recommended dosage). The AUC of capecitabine’s metabolites 5’-DFUR and fluorouracil increased greater than proportional to the dose. The interpatient variability in the Cmax and AUC of fluorouracil was greater than 85%.[L44657]
Following oral administration of capecitabine 1,255 mg/m<sup>2</sup> orally twice daily (the recommended dosage when used as a single agent), the median Tmax of capecitabine and its metabolite fluorouracil was approximately 1.5 hours and 2 hours, respectively.[L44657]
|
Capecitabine undergoes metabolism by carboxylesterase and is hydrolyzed to 5’-DFCR. 5’-DFCR is subsequently converted to 5’-DFUR by cytidine deaminase. 5’-DFUR is then hydrolyzed by thymidine phosphorylase (dThdPase) enzymes to the active metabolite
fluorouracil.[L44657]
Fluorouracil is subsequently metabolized by dihydropyrimidine dehydrogenase to 5-fluoro-5, 6-dihydro-fluorouracil (FUH2). The pyrimidine ring of FUH2 is cleaved by dihydropyrimidinase to yield 5-fluoro-ureido-propionic acid (FUPA). Finally, FUPA is cleaved by β-ureido-propionase to α-fluoro-β-alanine (FBAL).[L44657]
|
Adequate studies investigating the carcinogenic potential of capecitabine have not been conducted. Capecitabine was not mutagenic in vitro to bacteria (Ames test) or mammalian cells (Chinese hamster V79/HPRT gene mutation assay). Capecitabine was clastogenic in vitro to human peripheral blood lymphocytes but not clastogenic in vivo to mouse bone marrow (micronucleus test). Fluorouracil causes mutations in bacteria and yeast. Fluorouracil also causes chromosomal abnormalities in the mouse micronucleus test in vivo.[L44657]
In studies of fertility and general reproductive performance in female mice, oral capecitabine doses of 760 mg/kg/day (about 2,300 mg/m2/day) disturbed estrus and consequently caused a decrease in fertility. In mice that became pregnant, no fetuses survived this dose. The disturbance in estrus was reversible. In males, this dose caused degenerative changes in the testes, including decreases in the number of spermatocytes and spermatids. In separate pharmacokinetic studies, this dose in mice produced 5’-DFUR AUC values about 0.7 times the corresponding values in patients administered the recommended daily dose.[L44657]
Based on findings in animal reproduction studies and its mechanism of action [see Clinical Pharmacology (12.1)], XELODA can cause fetal harm when administered to a pregnant woman. Available human data on XELODA use in pregnant women is not sufficient to inform the drug-associated risk. In animal reproduction studies, administration of capecitabine to pregnant animals during the period of organogenesis caused embryo lethality and teratogenicity in mice and embryo lethality in monkeys at 0.2 and 0.6 times the exposure (AUC) in patients receiving the recommended dose of 1,250 mg/m2 twice daily, respectively. Advise pregnant women of the potential risk to a fetus.[L44657]
The estimated background risk of major birth defects and miscarriage for the indicated population is unknown. All pregnancies have a background risk of birth defect, loss, or other adverse outcomes. In the U.S. general population, the estimated background risk of major birth defects and miscarriage in clinically recognized pregnancies is 2% to 4% and 15% to 20%, respectively.[L44657]
Administer uridine triacetate within 96 hours for management of XELODA overdose. Although no clinical experience using dialysis as a treatment for XELODA overdose has been reported, dialysis may be of benefit in reducing circulating concentrations of 5’-DFUR, a low–molecular-weight metabolite of the parent compound.[L44657]
|
The elimination half-lives of capecitabine and fluorouracil were approximately 0.75 hour.[L44657]
|
Plasma protein binding of capecitabine and its metabolites is less than 60% and is not concentration dependent. Capecitabine was primarily bound to human albumin (approximately 35%).[L44657]
|
Following administration of radiolabeled capecitabine, 96% of the administered capecitabine dose was recovered in urine (3% unchanged and 57% as metabolite FBAL) and 2.6% in feces.[L44657]
|
In colorectal cancer patients with a mean age of 58 ± 9.5 years and ECOG Performance Status of 0–1, the volume of distribution is calculated to be 186 ± 28 L.[A255957]
|
In colorectal cancer patients with a mean age of 58 ± 9.5 years and ECOG Performance Status of 0–1, the clearance of capecitabine is calculated to be 775 ± 213 mL/min.[A255957]
|
Organic compounds
|
Nucleosides, nucleotides, and analogues
|
5'-deoxyribonucleosides
| null |
[
"approved",
"investigational"
] |
[
"L01BC",
"L01B",
"L01",
"L"
] |
[
"Humans and other mammals"
] |
[
{
"cost": "8.69",
"description": "Xeloda 150 mg tablet",
"unit": "tablet"
},
{
"cost": "28.97",
"description": "Xeloda 500 mg tablet",
"unit": "tablet"
}
] |
[
{
"approved": "1995-12-05",
"country": "United States",
"expires": "2013-12-14",
"number": "5472949"
},
{
"approved": "1990-10-30",
"country": "United States",
"expires": "2011-01-13",
"number": "4966891"
},
{
"approved": "1997-12-23",
"country": "Canada",
"expires": "2013-11-17",
"number": "2103324"
},
{
"approved": "1994-03-01",
"country": "Canada",
"expires": "2011-03-01",
"number": "1327358"
}
] |
(1-(5-Deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-carbamic acid pentyl ester | Capecitabin | Capecitabina | Capecitabine | Capécitabine | Capecitabinum | Pentyl [1-(5-deoxy-β-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]carbamate | pentyl 1-(5-deoxy-β-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamate | 2.1.1.45 | CDC21 | TS | TSA1 | 2.1.1.45 | TS | TSase | 2.4.2.4 | ECGF1 | Gliostatin | PD-ECGF | Platelet-derived endothelial cell growth factor | TdRPase | TP | ACAT | Acyl-coenzyme A:cholesterol acyltransferase | Brain carboxylesterase hBr1 | Carboxylesterase 1 | CE-1 | CEH | CES2 | Cholesteryl ester hydrolase | Cocaine carboxylesterase | Egasyn | hCE-1 | HMSE | Methylumbelliferyl-acetate deacetylase 1 | Monocyte/macrophage serine esterase | REH | Retinyl ester hydrolase | Serine esterase 1 | SES1 | TGH | Triacylglycerol hydrolase | 3.5.4.5 | CDD | Cytidine aminohydrolase | (R)-limonene 6-monooxygenase | (S)-limonene 6-monooxygenase | (S)-limonene 7-monooxygenase | 1.14.14.1 | Cholesterol 25-hydroxylase | CYP2C10 | CYPIIC9 | Cytochrome P-450MP | Cytochrome P450 MP-4 | Cytochrome P450 MP-8 | Cytochrome P450 PB-1 | S-mephenytoin 4-hydroxylase | 2.4.2.3 | UP | UPase 1 | UrdPase 1 | 2.4.2.3 | UPase 2 | UrdPase 2
|
[
"Ach-capecitabine",
"Ach-capecitabine",
"Apo-capecitabine",
"Apo-capecitabine",
"Capecitabine",
"Capecitabine",
"Capecitabine",
"Capecitabine",
"Capecitabine",
"Capecitabine",
"Capecitabine",
"Capecitabine",
"Capecitabine",
"Capecitabine",
"Capecitabine",
"Capecitabine",
"Capecitabine",
"Capecitabine",
"Capecitabine",
"Capecitabine",
"Capecitabine",
"Capecitabine",
"Capecitabine",
"Capecitabine",
"Capecitabine",
"Capecitabine",
"Capecitabine",
"Capecitabine",
"Capecitabine",
"Capecitabine",
"Capecitabine",
"Capecitabine",
"Capecitabine",
"Capecitabine",
"Capecitabine",
"Capecitabine",
"Capecitabine",
"Capecitabine",
"Capecitabine",
"Capecitabine",
"Capecitabine",
"Capecitabine",
"Capecitabine",
"Capecitabine",
"Capecitabine",
"Capecitabine",
"Capecitabine",
"Capecitabine",
"Capecitabine",
"Capecitabine",
"Capecitabine",
"Capecitabine",
"Capecitabine",
"Capecitabine",
"Capecitabine",
"Capecitabine",
"Capecitabine",
"Capecitabine",
"Capecitabine",
"Capecitabine",
"Capecitabine",
"Capecitabine",
"Capecitabine",
"Capecitabine",
"Capecitabine",
"Capecitabine",
"Capecitabine",
"Capecitabine",
"Capecitabine",
"Capecitabine",
"Capecitabine 150mg",
"Capecitabine 150mg",
"Capecitabine 500mg",
"Capecitabine 500mg",
"Capecitabine Accord",
"Capecitabine Accord",
"Capecitabine Accord",
"Capecitabine Accord",
"Capecitabine Accord",
"Capecitabine Accord",
"Capecitabine Accord",
"Capecitabine Accord",
"Capecitabine Accord",
"Capecitabine Accord",
"Capecitabine Accord",
"Capecitabine Accord",
"Capecitabine Accord",
"Capecitabine Accord",
"Capecitabine Accord",
"Capecitabine Accord",
"Capecitabine Accord",
"Capecitabine Accord",
"Capecitabine Accord",
"Capecitabine Accord",
"Capecitabine Accord",
"Capecitabine Accord",
"Capecitabine Accord",
"Capecitabine Accord",
"Capecitabine Accord",
"Capecitabine Accord",
"Capecitabine Accord",
"Capecitabine Medac",
"Capecitabine Medac",
"Capecitabine Medac",
"Capecitabine Medac",
"Capecitabine Medac",
"Capecitabine Medac",
"Capecitabine Medac",
"Capecitabine Medac",
"Capecitabine Medac",
"Capecitabine Medac",
"Capecitabine Medac",
"Capecitabine Medac",
"Capecitabine Medac",
"Capecitabine Medac",
"Capecitabine Medac",
"Capecitabine Medac",
"Capecitabine Medac",
"Capecitabine Medac",
"Capecitabine Medac",
"Capecitabine Medac",
"Capecitabine Medac",
"Capecitabine Medac",
"Capecitabine Medac",
"Capecitabine Medac",
"Capecitabine Medac",
"Capecitabine Medac",
"Capecitabine Medac",
"Capecitabine Medac",
"Capecitabine Medac",
"Capecitabine Medac",
"Capecitabine Medac",
"Capecitabine Medac",
"Capecitabine Medac",
"Capecitabine Medac",
"Capecitabine Medac",
"Capecitabine Medac",
"Capecitabine Medac",
"Capecitabine Medac",
"Capecitabine Medac",
"Capecitabine Medac",
"Capecitabine Medac",
"Capecitabine Medac",
"Capecitabine Sun",
"Capecitabine Sun",
"Capecitabine Tablets, 150 mg",
"Capecitabine Tablets, 500 mg",
"Capecitabine Teva",
"Capecitabine Teva",
"Ecansya",
"Ecansya",
"Ecansya",
"Ecansya",
"Ecansya",
"Ecansya",
"Ecansya",
"Ecansya",
"Ecansya",
"Ecansya",
"Ecansya",
"Ecansya",
"Ecansya",
"Ecansya",
"Ecansya",
"Ecansya",
"Ecansya",
"Ecansya",
"Mint-capecitabine",
"Mint-capecitabine",
"Sandoz Capecitabine",
"Sandoz Capecitabine",
"Taro-capecitabine",
"Taro-capecitabine",
"Teva-capecitabine",
"Teva-capecitabine",
"Xeloda",
"Xeloda",
"Xeloda",
"Xeloda",
"Xeloda",
"Xeloda",
"Xeloda",
"Xeloda",
"Xeloda",
"Xeloda",
"Xeloda"
] |
[] |
[] |
[
"P04818"
] |
[
"P19971",
"P23141",
"P32320",
"P11712",
"Q16831",
"O95045"
] |
[
"P02768"
] |
[] |
DB00372
|
Thiethylperazine
|
A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457)
|
liquid
|
For the treatment or relief of nausea and vomiting.
|
Thiethylperazine, an atypical antipsychotic agent, is used to treat both negative and positive symptoms of schizophrenia, acute mania with bipolar disorder, agitation, and psychotic symptoms in dementia. Future uses may include the treatment of obsessive-compulsive disorder and severe behavioral disorders in autism. Structurally and pharmacologically similar to clozapine, Thiethylperazine binds to alpha(1), dopamine, histamine H1, muscarinic, and serotonin type 2 (5-HT2) receptors.
|
Thiethylperazine is an antagonist at types 1, 2, and 4 dopamine receptors, 5-HT receptor types 2A and 2C, muscarinic receptors 1 through 5, alpha(1)-receptors, and histamine H1-receptors. Thiethylperazine's antipsychotic effect is due to antagonism at dopamine and serotonin type 2 receptors, with greater activity at serotonin 5-HT2 receptors than at dopamine type-2 receptors. This may explain the lack of extrapyramidal effects. Thiethylperazine does not appear to block dopamine within the tubero-infundibular tract, explaining the lower incidence of hyperprolactinemia than with typical antipsychotic agents or risperidone. Antagonism at muscarinic receptors, H1-receptors, and alpha(1)-receptors also occurs with thiethylperazine.
| null | null |
Manifestations of acute overdosage of TORECAN (thiethylperazine) can be expected to reflect the CNS effects of the drug and include extrapyramidal symptoms (E.P.S), confusion and convulsions with reduced or absent reflexes, respiratory depression and hypotension.
| null |
60%
|
Thiethylperazine is eliminated in the urine.
| null | null |
Organic compounds
|
Organoheterocyclic compounds
|
Benzothiazines
|
Phenothiazines
|
[
"approved",
"withdrawn"
] |
[
"R06AD",
"R06A",
"R06",
"R"
] |
[
"Humans and other mammals"
] |
[] |
[] |
2-(ethylthio)-10-[3-(4-methylpiperazin-1-yl)propyl]-10H-phenothiazine | Norzine | Thiethylperazin | Thiéthylpérazine | Thiethylperazine | Thiethylperazinum | Tietilperazina | Dopamine D2 receptor
|
[
"Torecan",
"Torecan"
] |
[] |
[] |
[
"P14416"
] |
[] |
[] |
[] |
DB00373
|
Timolol
|
Timolol is a nonselective beta-adrenergic antagonist given in an eye drop solution to reduce intraocular pressure, or pressure in the eyes.[L6724] It is also used in tablet form as a drug to treat hypertension.[L6727] Timolol was first approved by the FDA in 1978.[L6724] This drug is marketed by several manufacturers [L6736] and is an effective agent for the management of conditions such as open-angle glaucoma and hypertension.
|
solid
|
Ophthalmic timolol is indicated for the treatment of increased intraocular pressure in patients with ocular hypertension or open-angle glaucoma. The oral form of this drug is used to treat high blood pressure.[L6724,L6727] In certain cases, timolol is used in the prevention of migraine headaches.[A179530,L6742]
|
Timolol, when administered by the ophthalmic route, rapidly reduces intraocular pressure. When administered in the tablet form, it reduces blood pressure, heart rate, and cardiac output, and decreases sympathetic activity.[A179506,A179509,A179512,L6727]. This drug has a fast onset of action, usually occurring within 20 minutes of the administration of an ophthalmic dose. Timolol maleate can exert pharmacological actions for as long as 24 hours if given in the 0.5% or 0.25% doses.[L6757]
|
Timolol competes with adrenergic neurotransmitters for binding to beta(1)-adrenergic receptors in the heart and the beta(2)-receptors in the vascular and bronchial smooth muscle. This leads to diminished actions of catecholamines, which normally bind to adrenergic receptors and exert sympathetic effects leading to an increase in blood pressure and heart rate.[A179521] Beta(1)-receptor blockade by timolol leads to a decrease in both heart rate and cardiac output during rest and exercise, and a decrease in both systolic and diastolic blood pressure.[A179524,A179527] In addition to this, a reduction in reflex orthostatic hypotension may also occur. The blockade of beta(2) receptors by timolol in the blood vessels leads to a decrease in peripheral vascular resistance, reducing blood pressure.[L6724,L6727,L6733]
The exact mechanism by which timolol reduces ocular pressure is unknown at this time, however, it likely decreases the secretion of aqueous humor in the eye.[L6730] According to one study, the reduction of aqueous humor secretion may occur through the decreased blood supply to the ciliary body resulting from interference with the active transport system or interference with prostaglandin biosynthesis.[A179515]
|
The systemic bioavailability of the ophthalmic eyedrop in one study of healthy volunteers was 78.0 ± 24.5% [A179539], indicating that caution must be observed when this drug is administered, as it may be significantly absorbed and have various systemic effects. Another study measured the bioavailability of timolol eyedrops to be 60% in healthy volunteers.[A179548]
The peak concentration of ophthalmic timolol in plasma, Cmax was about 1.14 ng/ml in most subjects within 15 minutes following the administration of timolol by the ophthalmic route. The mean area under the curve (AUC) was about 6.46 ng/ml per hour after intravenous injection and about 4.78 ng/ml per hour following eyedrop administration.[A179539]
|
Timolol is metabolized in the liver by the cytochrome P450 2D6 enzyme, with minor contributions from CYP2C19.[A179551,L6724] 15-20% of a dose undergoes first-pass metabolism.[A179560] Despite its relatively low first pass metabolism, timolol is 90% metabolized.[A179560] Four metabolites of timolol have been identified, with a hydroxy metabolite being the most predominant.[A179551]
|
The oral LD50 for timolol maleate is 1028 mg/kg in the rat and 1137 mg/kg in the mouse.[MSDS]
Symptoms of timolol overdose may include dizziness, headache, shortness of breath, bradycardia, in addition to bronchospasm. Sometimes, an overdose may lead to cardiac arrest. An overdose of timolol can be reversed with dialysis, however, patients with renal failure may not respond as well to dialysis treatment.[L6724]
|
Timolol half-life was measured at 2.9 ± 0.3 h hours in a clinical study of healthy volunteers.[A179560]
|
The plasma protein binding of timolol is not extensive and is estimated to be about 10%.[L6727,L6]
|
Timolol and its metabolites are mainly found excreted in the urine.[A179560]
|
1.3 - 1.7 L/kg [L6]
Timolol is distributed to the following tissues: the conjunctiva, cornea, iris, sclera, aqueous humor, kidney, liver, and lung.[L6]
|
One pharmacokinetic study in healthy volunteers measured the total plasma clearance of timolol to be 557 ± 61 ml/min.[A179557] Another study determined the total clearance 751.5 ± 90.6 ml/min and renal clearance to be 97.2 ± 10.1 ml/min in healthy volunteers.[A179560]
|
Organic compounds
|
Organic nitrogen compounds
|
Organonitrogen compounds
|
Amines
|
[
"approved"
] |
[
"C07AA",
"C07A",
"C07",
"C",
"S01ED",
"S01E",
"S01",
"S",
"C07BA",
"C07B",
"C07",
"C",
"C07DA",
"C07D",
"C07",
"C",
"S01ED",
"S01E",
"S01",
"S"
] |
[
"Humans and other mammals"
] |
[
{
"cost": "1.62",
"description": "Apo-Timop 0.25 % Solution",
"unit": "ml"
},
{
"cost": "1.62",
"description": "Mylan-Timolol 0.25 % Solution",
"unit": "ml"
},
{
"cost": "1.62",
"description": "Pms-Timolol 0.25 % Solution",
"unit": "ml"
},
{
"cost": "1.62",
"description": "Sandoz Timolol Maleate 0.25 % Solution",
"unit": "ml"
},
{
"cost": "1.95",
"description": "Apo-Timop 0.5 % Solution",
"unit": "ml"
},
{
"cost": "1.95",
"description": "Mylan-Timolol 0.5 % Solution",
"unit": "ml"
},
{
"cost": "1.95",
"description": "Pms-Timolol 0.5 % Solution",
"unit": "ml"
},
{
"cost": "1.95",
"description": "Sandoz Timolol Maleate 0.5 % Solution",
"unit": "ml"
},
{
"cost": "2.78",
"description": "Timolol 0.25% eye drops",
"unit": "ml"
},
{
"cost": "3.24",
"description": "Timolol 0.5% eye drops",
"unit": "ml"
},
{
"cost": "3.63",
"description": "Timoptic 0.5 % Solution",
"unit": "ml"
},
{
"cost": "3.8",
"description": "Timoptic 0.25% ocudose drops",
"unit": "each"
},
{
"cost": "3.88",
"description": "Timoptic-Xe 0.25 % Long Acting Gellan Solution",
"unit": "ml"
},
{
"cost": "4.57",
"description": "Timoptic 0.5% ocudose drops",
"unit": "each"
},
{
"cost": "4.64",
"description": "Timoptic-Xe 0.5 % Long Acting Gellan Solution",
"unit": "ml"
},
{
"cost": "7.32",
"description": "Timoptic 0.25% eye drops",
"unit": "ml"
},
{
"cost": "8.63",
"description": "Timoptic 0.5% eye drops",
"unit": "ml"
},
{
"cost": "9.19",
"description": "Betimol 0.25% eye drops",
"unit": "ml"
},
{
"cost": "10.15",
"description": "Betimol 0.5% eye drops",
"unit": "ml"
},
{
"cost": "11.51",
"description": "Timoptic-xe 0.25% eye solution",
"unit": "ml"
},
{
"cost": "13.6",
"description": "Timoptic-xe 0.5% eye solution",
"unit": "ml"
},
{
"cost": "15.6",
"description": "Timolol Maleate 0.25% Solution 5ml Bottle",
"unit": "bottle"
},
{
"cost": "17.68",
"description": "Timolol Maleate 0.5% Solution 5ml Bottle",
"unit": "bottle"
},
{
"cost": "23.99",
"description": "Timoptic-XE 0.25% Gel Forming Solution 2.5ml Bottle",
"unit": "bottle"
},
{
"cost": "28.87",
"description": "Timolol Maleate 0.25% Solution 10ml Bottle",
"unit": "bottle"
},
{
"cost": "33.58",
"description": "Timolol Maleate 0.5% Solution 10ml Bottle",
"unit": "bottle"
},
{
"cost": "36.43",
"description": "Istalol 0.5% eye drops",
"unit": "ml"
},
{
"cost": "43.06",
"description": "Timoptic 0.25% Solution 5ml Bottle",
"unit": "bottle"
},
{
"cost": "43.68",
"description": "Timolol Maleate 0.25% Solution 15ml Bottle",
"unit": "bottle"
},
{
"cost": "46.74",
"description": "Timolol Maleate 0.5% Gel Forming Solution 2.5ml Bottle",
"unit": "bottle"
},
{
"cost": "49.99",
"description": "Betimol 0.25% Solution 10ml Bottle",
"unit": "bottle"
},
{
"cost": "50.7",
"description": "Timolol Maleate 0.5% Solution 15ml Bottle",
"unit": "bottle"
},
{
"cost": "55.56",
"description": "Betimol 0.25% Solution 5ml Bottle",
"unit": "bottle"
},
{
"cost": "59.71",
"description": "Timolol Maleate 0.25% Gel Forming Solution 5ml Bottle",
"unit": "bottle"
},
{
"cost": "59.8",
"description": "Timoptic 0.5% Solution 5ml Bottle",
"unit": "bottle"
},
{
"cost": "60.84",
"description": "Timolol Maleate 0.5% Gel Forming Solution 5ml Bottle",
"unit": "bottle"
},
{
"cost": "63.43",
"description": "Betimol 0.5% Solution 5ml Bottle",
"unit": "bottle"
},
{
"cost": "65.37",
"description": "Timoptic-XE 0.25% Gel Forming Solution 5ml Bottle",
"unit": "bottle"
},
{
"cost": "83.2",
"description": "Timoptic 0.5% Solution 10ml Bottle",
"unit": "bottle"
},
{
"cost": "85.09",
"description": "Timoptic-XE 0.5% Gel Forming Solution 5ml Bottle",
"unit": "bottle"
},
{
"cost": "93.56",
"description": "Betimol 0.25% Solution 15ml Bottle",
"unit": "bottle"
},
{
"cost": "106.88",
"description": "Betimol 0.5% Solution 10ml Bottle",
"unit": "bottle"
},
{
"cost": "107.1",
"description": "Timolol maleate powder",
"unit": "g"
},
{
"cost": "152.24",
"description": "Betimol 0.5% Solution 15ml Bottle",
"unit": "bottle"
},
{
"cost": "0.03",
"description": "Aquanil cleanser",
"unit": "ml"
},
{
"cost": "0.12",
"description": "Aquanil hc 1% lotion",
"unit": "ml"
},
{
"cost": "0.19",
"description": "Apo-Timol 5 mg Tablet",
"unit": "tablet"
},
{
"cost": "0.19",
"description": "Novo-Timol 5 mg Tablet",
"unit": "tablet"
},
{
"cost": "0.19",
"description": "Nu-Timolol 5 mg Tablet",
"unit": "tablet"
},
{
"cost": "0.3",
"description": "Apo-Timol 10 mg Tablet",
"unit": "tablet"
},
{
"cost": "0.3",
"description": "Novo-Timol 10 mg Tablet",
"unit": "tablet"
},
{
"cost": "0.3",
"description": "Nu-Timolol 10 mg Tablet",
"unit": "tablet"
},
{
"cost": "0.41",
"description": "Timolol maleate 5 mg tablet",
"unit": "tablet"
},
{
"cost": "0.51",
"description": "Timolol maleate 10 mg tablet",
"unit": "tablet"
},
{
"cost": "0.59",
"description": "Apo-Timol 20 mg Tablet",
"unit": "tablet"
},
{
"cost": "0.59",
"description": "Novo-Timol 20 mg Tablet",
"unit": "tablet"
},
{
"cost": "0.6",
"description": "Hydrocortisone 2.5% lotion",
"unit": "ml"
},
{
"cost": "0.94",
"description": "Timolol maleate 20 mg tablet",
"unit": "tablet"
}
] |
[
{
"approved": "1993-07-27",
"country": "United States",
"expires": "2010-07-27",
"number": "5231095"
},
{
"approved": "2001-01-16",
"country": "United States",
"expires": "2019-09-26",
"number": "6174524"
},
{
"approved": "2006-04-18",
"country": "United States",
"expires": "2022-04-19",
"number": "7030149"
},
{
"approved": "2008-01-22",
"country": "United States",
"expires": "2022-04-19",
"number": "7320976"
},
{
"approved": "2010-01-05",
"country": "United States",
"expires": "2022-04-19",
"number": "7642258"
},
{
"approved": "2012-03-13",
"country": "United States",
"expires": "2022-04-19",
"number": "8133890"
},
{
"approved": "2013-01-15",
"country": "United States",
"expires": "2022-04-19",
"number": "8354409"
},
{
"approved": "2014-06-10",
"country": "United States",
"expires": "2022-04-19",
"number": "8748425"
},
{
"approved": "2008-01-29",
"country": "United States",
"expires": "2023-01-19",
"number": "7323463"
},
{
"approved": "2002-01-01",
"country": "United States",
"expires": "2018-11-02",
"number": "6335335"
},
{
"approved": "2003-11-11",
"country": "United States",
"expires": "2018-11-16",
"number": "6645963"
},
{
"approved": "2016-10-25",
"country": "United States",
"expires": "2022-04-19",
"number": "9474751"
},
{
"approved": "2017-09-26",
"country": "United States",
"expires": "2022-04-19",
"number": "9770453"
},
{
"approved": "2018-03-06",
"country": "United States",
"expires": "2022-04-19",
"number": "9907801"
},
{
"approved": "2018-03-06",
"country": "United States",
"expires": "2022-04-19",
"number": "9907802"
}
] |
(S)-1-(tert-butylamino)-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol | Timolol | Timolol anhydrous | Timololo | Timololum | ADRB1R | B1AR | Beta-1 adrenoceptor | Beta-1 adrenoreceptor | ADRB2R | B2AR | Beta-2 adrenoceptor | Beta-2 adrenoreceptor | 3.2.1.17 | Lysis protein | Lysozyme | Muramidase | (R)-limonene 6-monooxygenase | (S)-limonene 6-monooxygenase | (S)-limonene 7-monooxygenase | 1.14.14.1 | CYPIIC17 | CYPIIC19 | Cytochrome P450-11A | Cytochrome P450-254C | Fenbendazole monooxygenase (4'-hydroxylating) | Mephenytoin 4-hydroxylase | 1.14.14.- | Cholesterol 25-hydroxylase | CYP2DL1 | CYPIID6 | Cytochrome P450-DB1 | Debrisoquine 4-hydroxylase | ATP-binding cassette sub-family B member 1 | MDR1 | Multidrug resistance protein 1 | P-glycoprotein 1 | PGY1 | Phospholipid transporter ABCB1
|
[
"Act Dorzotimolol",
"Act Latanoprost/timolol",
"Ag-dorzolamide Timolol",
"Apo-brimonidine-timop",
"Apo-dorzo-timop",
"Apo-latanoprost-timop",
"Apo-timop",
"Apo-timop",
"Apo-timop Gel",
"Apo-timop Gel",
"Apo-travoprost-timolol Pq",
"Apo-travoprost-timop Pq",
"Azarga",
"Azarga",
"Azarga",
"Beta-tim - 0.25% Liq",
"Beta-tim - 0.5% Liq",
"Betimol",
"Betimol",
"Betimol",
"Betimol",
"Betimol",
"Betimol",
"Blocadren",
"Blocadren",
"Blocadren",
"Blocadren Tab 10mg",
"Blocadren Tab 20mg",
"Blocadren Tab 5mg",
"Brimonidine Tartrate and Timolol Maleate",
"BRIMONIDINE TARTRATE and TIMOLOL MALEATE",
"Brimonidine Tartrate and Timolol Maleate",
"Brimonidine Tartrate and Timolol Maleate",
"Brimonidine Tartrate and Timolol Maleate",
"Brimonidine tartrate and Timolol maleate",
"Brimonidine Tartrate and Timolol Maleate",
"Brimonidine Tartrate and Timolol Maleate",
"Brimonidine Tartrate and Timolol Maleate",
"Brimonidine Tartrate/Timolol Maleate",
"Brimonidine Tartrate/Timolol Maleate",
"Brimonidine Tartrate/Timolol Maleate",
"Brimonidine Tartrate/Timolol Maleate",
"Brimonidine Tartrate/Timolol Maleate Ophthalmic Solution",
"Brimonidine Tartrate/Timolol Maleate Ophthalmic Solution",
"Combigan",
"Combigan",
"Combigan",
"Cosopt",
"Cosopt",
"Cosopt",
"Cosopt",
"Cosopt",
"Cosopt PF",
"Cosopt PF",
"Cosopt PF",
"Cosopt Preservative-free",
"Dom-timolol",
"Dom-timolol",
"Dorzolamide and Timolol",
"Dorzolamide and Timolol",
"Dorzolamide and Timolol Eye Drops BP",
"Dorzolamide HCl /Timolol Maleate",
"Dorzolamide HCl and Timolol Maleate",
"Dorzolamide HCl and Timolol Maleate",
"Dorzolamide HCl and Timolol Maleate",
"Dorzolamide Hydrochloride and Timolol Maleate",
"Dorzolamide Hydrochloride and Timolol Maleate",
"Dorzolamide Hydrochloride and Timolol Maleate",
"Dorzolamide Hydrochloride and Timolol Maleate",
"Dorzolamide Hydrochloride and Timolol Maleate",
"Dorzolamide Hydrochloride and Timolol Maleate",
"Dorzolamide Hydrochloride and Timolol Maleate",
"DORZOLAMIDE HYDROCHLORIDE and TIMOLOL MALEATE",
"Dorzolamide Hydrochloride and Timolol Maleate",
"Dorzolamide Hydrochloride and Timolol Maleate",
"Dorzolamide Hydrochloride and Timolol Maleate",
"Dorzolamide Hydrochloride and Timolol Maleate",
"Dorzolamide Hydrochloride and Timolol Maleate",
"Dorzolamide Hydrochloride and Timolol Maleate",
"Dorzolamide hydrochloride and timolol maleate",
"Dorzolamide Hydrochloride and Timolol Maleate",
"Dorzolamide Hydrochloride and Timolol Maleate",
"Dorzolamide Hydrochloride and Timolol Maleate",
"Dorzolamide Hydrochloride and Timolol Maleate ophthalmic",
"Dorzolamide Hydrochloride and Timolol Maleate ophthalmic Solution",
"Dorzolamide Hydrochloride and Timolol Maleate Ophthalmic Solution",
"Dorzolamide Hydrochloride and Timolol Maleate Ophthalmic Solution",
"Dorzolamide Hydrochloride and Timolol Maleate ophthalmic Solution",
"Dorzolamide Hydrochloride and Timolol Maleate Ophthalmic Solution",
"Dorzolamide Hydrochloride and Timolol Maleate Preservative Free",
"Dorzolamide Hydrochloride Timolol Maleate",
"Dorzolamide Hydrochloride Timolol Maleate",
"Dorzolamide Hydrochloride Timolol Maletae",
"Dorzolamide Hydrochloride-Timolol Maleate",
"Dorzolamide Hydrochloride-timolol Maleate",
"Dorzolamide Hydrochloride-Timolol Maleate",
"Dorzolamide Hydrochloride-Timolol Maleate Ophthalmic Solution Sterile Ophthalmic Solution",
"Dorzolamide-timolol",
"Dorzolamide-timolol",
"Dorzolamide-timolol",
"Dorzolamide-timolol PF",
"Duokopt",
"Duotrav",
"Duotrav",
"Duotrav",
"Duotrav",
"Duotrav",
"Duotrav",
"Duotrav Pq",
"Ganfort",
"Ganfort",
"Ganfort",
"Ganfort",
"Ganfort",
"Istalol",
"Istalol",
"Jamp Brimonidine/timolol",
"Jamp Dorzolamide-timolol",
"Jamp-latanoprost/timolol",
"Jamp-timolol",
"Latanoprost and Timolol Ophthalmic Solution",
"M-dorzolamide-timolol",
"M-latanoprost-timolol",
"Med Timolol Liq Oph 0.25%",
"Med Timolol Liq Oph 0.5%",
"Med-dorzolamide-timolol",
"Med-latanoprost-timolol",
"Mint-dorzolamide/timolol",
"Mint-latanoprost/timolol",
"Mylan-dorzolamide/timolol",
"Mylan-latanoprost/timolol",
"Mylan-latanoprost/timolol",
"Mylan-timolol",
"Mylan-timolol",
"Novo-timol Liq 0.25%",
"Novo-timol Liq 0.5%",
"Nu-timolol Tab 10mg",
"Nu-timolol Tab 20mg",
"Nu-timolol Tab 5mg",
"Odan-timolol",
"Odan-timolol",
"PMS-dorzolamide-timolol",
"PMS-latanoprost-timolol",
"PMS-timolol",
"PMS-timolol",
"Priva-dorzolamide-timolol",
"Ratio-timolol Maleate 0.25%",
"Ratio-timolol Maleate 0.5%",
"Rhoxal-timolol 0.25%",
"Rhoxal-timolol 0.5%",
"Riva-dorzolamide/timolol",
"Riva-latanoprost/timolol",
"Sandoz Brimonidine / Timolol",
"Sandoz Dorzolamide/timolol",
"Sandoz Latanoprost/timolol",
"Sandoz Timolol",
"Sandoz Timolol",
"Sandoz Travoprost / Timolol Pq",
"T-LO",
"T-LO",
"Teva-dorzotimol",
"Teva-latanoprost/timolol",
"Teva-timolol",
"Teva-timolol",
"Teva-timolol",
"Tim-Brim-Dor PF",
"Tim-Brim-Dor-Lat",
"Tim-Dor PF",
"Tim-Dor-Lat",
"Tim-Lat -PF",
"Timolide Tab",
"Timolol",
"Timolol",
"Timolol",
"Timolol",
"Timolol",
"Timolol GFS",
"Timolol GFS",
"Timolol GFS",
"Timolol hemihydrate",
"Timolol hemihydrate",
"Timolol Hemihydrate",
"Timolol Hemihydrate",
"Timolol Hemihydrate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol maleate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol maleate",
"Timolol maleate",
"Timolol maleate",
"Timolol maleate",
"Timolol maleate",
"Timolol maleate",
"Timolol maleate",
"Timolol maleate",
"Timolol maleate",
"Timolol maleate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol Maleate",
"Timolol Maleate Ophthalmic Gel Forming Solution",
"Timolol Maleate Ophthalmic Gel Forming Solution",
"Timolol Maleate Ophthalmic Gel Forming Solution",
"Timolol Maleate Ophthalmic Gel Forming Solution",
"Timolol Maleate Ophthalmic Gel Forming Solution 0.25%",
"Timolol Maleate Ophthalmic Gel Forming Solution 0.25%",
"Timolol Maleate Ophthalmic Gel Forming Solution 0.5%",
"Timolol Maleate Ophthalmic Gel Forming Solution 0.5%",
"Timolol Maleate Ophthalmic Gel Forming Solution, 0.25%",
"Timolol Maleate Ophthalmic Gel Forming Solution, 0.5%",
"Timolol Maleate Ophthalmic Solution",
"Timolol Maleate Ophthalmic Solution",
"Timolol Maleate Ophthalmic Solution",
"Timolol Maleate-EX",
"Timolol Maleate-EX",
"Timolol Solution - 0.25%",
"Timolol Solution - 0.5%",
"Timolol-10 Tab 10mg",
"Timolol-20 Tab 20mg",
"Timolol-5 Tab 5mg",
"Timoptic",
"Timoptic",
"Timoptic",
"Timoptic",
"Timoptic",
"Timoptic",
"Timoptic",
"Timoptic",
"Timoptic",
"Timoptic",
"Timoptic",
"Timoptic",
"Timoptic",
"Timoptic in Ocudose",
"Timoptic in Ocudose",
"Timoptic in Ocudose",
"Timoptic in Ocudose",
"Timoptic in Ocudose",
"Timoptic in Ocudose",
"Timoptic PF",
"Timoptic-XE",
"Timoptic-XE",
"Timoptic-XE",
"Timoptic-XE",
"Timoptic-XE",
"Timoptic-XE",
"Timoptic-XE",
"Timoptic-XE",
"Timoptic-XE",
"Timoptic-XE",
"Timpilo 2",
"Timpilo 4",
"Van-dorzolamide-timolol",
"Xalacom"
] |
[
"Proflax",
"Tenopt",
"Timacar Depot",
"Timacor",
"Timoptol"
] |
[
"Dorzolamide Hydrochloride and Timolol Maleate",
"Combigan",
"Cosopt",
"Dorzolamide Hydrochloride-Timolol Maleate",
"Dorzolamide Hydrochloride and Timolol Maleate",
"Cosopt PF",
"Cosopt",
"Dorzolamide HCl and Timolol Maleate",
"Dorzolamide HCl /Timolol Maleate",
"Dorzolamide Hydrochloride and Timolol Maleate",
"Dorzolamide Hydrochloride-timolol Maleate",
"Dorzolamide HCl and Timolol Maleate",
"Cosopt",
"Dorzolamide HCl and Timolol Maleate",
"Tim-Lat -PF",
"Tim-Dor PF",
"Tim-Dor-Lat",
"Tim-Brim-Dor-Lat",
"Tim-Brim-Dor PF",
"Cosopt PF",
"Dorzolamide Hydrochloride and Timolol Maleate Preservative Free",
"Dorzolamide Hydrochloride and Timolol Maleate",
"Dorzolamide and Timolol",
"Dorzolamide Hydrochloride and Timolol Maleate",
"Combigan",
"Dorzolamide and Timolol",
"Dorzolamide Hydrochloride and Timolol Maleate",
"Dorzolamide Hydrochloride and Timolol Maleate",
"DORZOLAMIDE HYDROCHLORIDE and TIMOLOL MALEATE",
"Dorzolamide Hydrochloride and Timolol Maleate",
"Dorzolamide Hydrochloride and Timolol Maleate",
"Dorzolamide Hydrochloride-Timolol Maleate",
"Dorzolamide Hydrochloride and Timolol Maleate ophthalmic Solution",
"Dorzolamide Hydrochloride-Timolol Maleate Ophthalmic Solution Sterile Ophthalmic Solution",
"Dorzolamide Hydrochloride and Timolol Maleate Ophthalmic Solution",
"Dorzolamide Hydrochloride and Timolol Maleate",
"Dorzolamide Hydrochloride Timolol Maletae",
"Timolide Tab",
"Xalacom",
"Combigan",
"Teva-dorzotimol",
"Sandoz Dorzolamide/timolol",
"Mylan-latanoprost/timolol",
"Sandoz Latanoprost/timolol",
"Timpilo 2",
"Timpilo 4",
"Dorzolamide Hydrochloride and Timolol Maleate Ophthalmic Solution",
"PMS-latanoprost-timolol",
"Sandoz Travoprost / Timolol Pq",
"Mint-latanoprost/timolol",
"Teva-latanoprost/timolol",
"PMS-dorzolamide-timolol",
"Apo-travoprost-timop Pq",
"Jamp-latanoprost/timolol",
"Riva-dorzolamide/timolol",
"Cosopt",
"Cosopt Preservative-free",
"Mylan-dorzolamide/timolol",
"Mylan-latanoprost/timolol",
"Act Latanoprost/timolol",
"Mint-dorzolamide/timolol",
"Riva-latanoprost/timolol",
"Med-latanoprost-timolol",
"Duotrav Pq",
"Azarga",
"Jamp Dorzolamide-timolol",
"Apo-latanoprost-timop",
"Apo-dorzo-timop",
"Med-dorzolamide-timolol",
"Van-dorzolamide-timolol",
"Act Dorzotimolol",
"Latanoprost and Timolol Ophthalmic Solution",
"Dorzolamide and Timolol Eye Drops BP",
"Dorzolamide-timolol",
"Apo-travoprost-timolol Pq",
"Priva-dorzolamide-timolol",
"M-latanoprost-timolol",
"Dorzolamide-timolol",
"Dorzolamide Hydrochloride Timolol Maleate",
"Brimonidine Tartrate/Timolol Maleate",
"Dorzolamide Hydrochloride and Timolol Maleate",
"Brimonidine Tartrate and Timolol Maleate",
"Duokopt",
"Ag-dorzolamide Timolol",
"Dorzolamide-timolol",
"Brimonidine Tartrate/Timolol Maleate Ophthalmic Solution",
"Dorzolamide Hydrochloride and Timolol Maleate",
"Brimonidine Tartrate/Timolol Maleate",
"BRIMONIDINE TARTRATE and TIMOLOL MALEATE",
"Apo-brimonidine-timop",
"Cosopt",
"Cosopt PF",
"Brimonidine Tartrate and Timolol Maleate",
"Dorzolamide Hydrochloride and Timolol Maleate",
"Jamp Brimonidine/timolol",
"Dorzolamide hydrochloride and timolol maleate",
"M-dorzolamide-timolol",
"Dorzolamide Hydrochloride Timolol Maleate",
"Brimonidine Tartrate and Timolol Maleate",
"Brimonidine Tartrate and Timolol Maleate",
"Brimonidine Tartrate/Timolol Maleate Ophthalmic Solution",
"Sandoz Brimonidine / Timolol",
"Dorzolamide-timolol PF",
"Brimonidine Tartrate/Timolol Maleate",
"Dorzolamide Hydrochloride and Timolol Maleate ophthalmic",
"Brimonidine tartrate and Timolol maleate",
"Dorzolamide Hydrochloride and Timolol Maleate",
"Dorzolamide Hydrochloride and Timolol Maleate",
"Brimonidine Tartrate/Timolol Maleate",
"Dorzolamide Hydrochloride and Timolol Maleate ophthalmic Solution",
"Dorzolamide Hydrochloride and Timolol Maleate",
"Brimonidine Tartrate and Timolol Maleate",
"Brimonidine Tartrate and Timolol Maleate",
"Brimonidine Tartrate and Timolol Maleate",
"Dorzolamide Hydrochloride and Timolol Maleate Ophthalmic Solution",
"Azarga",
"Azarga",
"Ganfort",
"Ganfort",
"Ganfort",
"Ganfort",
"Ganfort",
"Duotrav",
"Duotrav",
"Duotrav",
"Duotrav",
"Duotrav",
"Duotrav"
] |
[
"P08588",
"P07550"
] |
[
"P33261",
"P10635"
] |
[] |
[
"P08183"
] |
DB00374
|
Treprostinil
|
Treprostinil is a stable tricyclic analogue of prostacyclin[A248770] that promotes the vasodilation of pulmonary and systemic arterial vascular beds and the inhibition of platelet aggregation.[L41855,L41860,L41865] It reduces symptoms in patients with pulmonary arterial hypertension (PAH) and pulmonary hypertension associated with interstitial lung disease.[L41855,L41860] The first agent approved for the treatment of PAH was [epoprostenol], a synthetic prostacyclin that significantly increases patients' quality of life. However, the use of epoprostenol is limited due to its short half-life (3-5 min) and instability at room temperature.[A248770,A248775] The use of more stable alternatives such as treprostinil provides patients with PAH with more treatment options.
Treprostinil was approved by the FDA in 2002 for the treatment of pulmonary arterial hypertension.[L41860] It is available in the following routes of administration: subcutaneous, intravenous, inhaled and oral. The first generic form of treprostinil became available in 2019.[A248775]
|
solid
|
The FDA has indicated treprostinil for the treatment of pulmonary arterial hypertension[L41855,L41860,L41865] and pulmonary hypertension associated with interstitial lung disease[L41855] to improve exercise ability. It is also used to treat pulmonary arterial hypertension in patients requiring transition from epoprostenol.[L41860] The Health Canada label specifies that treprostinil is indicated for the long-term treatment of pulmonary arterial hypertension in NYHA Class III and IV patients who did not respond adequately to conventional therapy.[L24244]
L24244
|
As an analogue of prostacyclin, treprostinil promotes the vasodilation of pulmonary and systemic arterial vascular beds and the inhibition of platelet aggregation [L41855,L41860,L41865]. In animals, the vasodilatory effects of treprostinil lead to a reduction of right and left ventricular afterload and an increase in cardiac output and stroke volume.[L41860] Treprostinil also causes a dose-related negative inotropic and lusitropic effect, and no major effects on cardiac conduction have been detected.[L41860] Short-lasting effects on QTc were detected in healthy volunteers (n=240) given inhaled single doses of 54 and 84 μg of treprostinil. These effects dissipated rapidly as treprostinil concentrations lowered.[L41855] When given subcutaneously or intravenously, treprostinil has the potential to reach higher concentrations.[L41860] The effect of oral treprostinil on QTc has not been evaluated.[L41865]
Due to its ability to inhibit platelet aggregation, treprostinil can increase the risk of bleeding, and patients with low systemic arterial pressure taking treprostinil may experience symptomatic hypotension.[L41855,L41860] The abrupt withdrawal of treprostinil or drastic changes in dose may worsen the symptoms of pulmonary arterial hypertension (PAH).[L41860,L41865] The inhalation of treprostinil can also cause bronchospasms in patients with asthma, chronic obstructive pulmonary disease (COPD), or bronchial hyperreactivity.[L41855] When given intravenously, treprostinil can lead to infusion complications and increase the risk of bloodstream infections.[L41860]
|
Treprostinil is a stable analogue of prostacyclin[L41855,L41860,L41865], a prostaglandin that acts as an anti-thrombotic agent and a potent vasodilator. Prostacyclin analogues are useful in the treatment of pulmonary arterial hypertension (PAH), a disease characterized by abnormally high blood pressure in the arteries between the heart and lungs.[A248770] PAH leads to right heart failure due to the remodelling of pulmonary arteries, and patients with this condition have a poor prognosis.[A248775]
Treprostinil binds and activates the prostacyclin receptor, the prostaglandin D2 receptor 1, and the prostaglandin E2 receptor 2.[A248770] The activation of these receptors leads to the elevation of intracellular cyclic adenosine monophosphate (cAMP) levels, which consequently promotes the opening of calcium-activated potassium channels that lead to cell hyperpolarization.[A248770] This mechanism promotes the direct vasodilation of pulmonary and systemic arterial vascular beds and the inhibition of platelet aggregation[A248735,L41855,L41860,L41865]. In addition to its direct vasodilatory effects, treprostinil inhibits inflammatory pathways.[A248765]
|
After subcutaneous infusion, treprostinil is completely absorbed, with a bioavailability of about 100%, and it reaches steady-state concentrations in approximately 10 hours.[L41860] The pharmacokinetics of treprostinil follow a two-compartment model and are linear between 2.5 and 125 ng/kg/min.[L41860] Subcutaneous and intravenous doses of treprostinil are bioequivalent at 10 ng/kg/min. Compared to healthy subjects, patients with mild and moderate hepatic insufficiency had a corresponding C<sub>max</sub> 2- and 4-times higher and an AUC<sub>0-∞</sub> 3- and 5-times higher when given a subcutaneous treprostinil dose of 10 ng/kg/min for 150 min.[L41860]
When given orally at doses between 0.5 and 15 mg twice a day, treprostinil follows a dose-proportional pharmacokinetic profile.[L41865] The oral bioavailability of treprostinil is 17%, and drug concentration reaches its highest level between 4 and 6 hours after oral administration.[L41865] The oral absorption of treprostinil is affected by food. The AUC and C<sub>max</sub> of oral treprostinil increase 49% and 13%, respectively, when this drug is administered with a high-fat, high-calorie meal.[L41865]
The AUC and C<sub>max</sub> of inhaled treprostinil were proportional to the doses administered (18 to 90 μg).[L41855] The bioavailability of inhaled treprostinil was 64% in patients receiving 2 doses of 18 μg, and 72% in patients receiving two doses of 36 μg.[L41855] Two separate studies that evaluated the pharmacokinetics of inhaled treprostinil at a maintenance dose of 54 μg found that the mean C<sub>max</sub> was 0.91 and 1.32 ng/mL, respectively, with a corresponding T<sub>max</sub> of 0.25 and 0.12 hr and a mean AUC of 0.81 and 0.97 hr⋅ng/mL.[L41855]
|
Treprostinil is mostly metabolized by the liver, mainly by CYP2C8, and by CYP2C9 to a lesser extent.[L41855,L41860,L41865] Treprostinil does not have a single major metabolite. The five metabolites detected in urine (HU1 through HU5) accounted for 13.8, 14.3, 15.5, 10.6 and 10.2% of the dose, respectively.[L41880] One of the metabolites (HU5) is the glucuronide conjugate of treprostinil. HU1, HU2, HU3 and HU4 are formed through the oxidation of the 3-hydroxyloctyl side chain.[L41855,L41860,L41865,L41880] None of the metabolites of treprostinil appear to be active. _In vitro_ studies suggest that treprostinil does not inhibit or induce any major CYP enzymes.[L41855,L41860]
|
Treprostinil overdose symptoms are an extension of its dose-limiting pharmacologic effects.[L41860] These include flushing, headache, hypotension, nausea, vomiting, and diarrhea.[L41855,L41860,L41865] Most overdose events were self-limiting and resolved by reducing or withholding treprostinil.[L41860] In studies where treprostinil was infused using an external pump, several patients received an overdose due to an accidental bolus administration, errors in the programmed delivery rate and incorrect prescriptions. Only two cases of of substantial hemodynamic concern were detected among patients that received an excess of treprostinil.[L41860] A pediatric patient that accidentally received 7.5 mg of treprostinil via a central venous catheter presented flushing, headache, nausea, vomiting, hypotension, and seizure-like activity with loss of consciousness for several minutes.[L41860]
A rat study that evaluated the carcinogenic effects of inhaled treprostinil, found no evidence of carcinogenicity in levels up to 35 times the clinical exposure obtained with a maintenance dose of 54 μg.[L41855] The infusion of treprostinil sodium did not affect fertility or mating performance in rats given subcutaneous treprostinil.[L41860] Treprostinil did not show mutagenic or clastogenic effects in _in vitro_ or _in vivo_ studies.[L41855,L41860] There was no significant increase of tumors in rats given up to 10 mg/kg/day of oral treprostinil diolamine.[L41865]
|
The terminal elimination half-life of treprostinil is approximately 4 hours, following a two-compartment model.[L41855,L41860]
|
At _in vitro_ concentrations ranging from 330 to 10,000 μg/L, the human plasma protein binding of treprostinil is approximately 91%. This concentration is above what is considered to be clinically relevant.[L41240,L41860]
|
Treprostinil metabolites are excreted through urine (79%) and feces (13%) over 10 days.[L41855,L41860] Only a small proportion of treprostinil is excreted unchanged. When administered orally, 1.13% and 0.19% of unchanged treprostinil diolamine are found in urine and feces, respectively.[L41865] When administered subcutaneously, intravenously or by inhalation, 4% of unchanged treprostinil is found in urine.[L41855,L41860]
|
The volume of distribution of treprostinil is 14 L/70 kg.[L41855,L41860]
|
The clearance of treprostinil is 30 L/hr in a 70 kg person.[L41860] In patients with mild to moderate hepatic insufficiency, clearance is reduced up to 80%.[L41855]
|
Organic compounds
|
Benzenoids
|
Benzene and substituted derivatives
|
Phenoxyacetic acid derivatives
|
[
"approved",
"investigational"
] |
[
"B01AC",
"B01A",
"B01",
"B"
] |
[
"Humans and other mammals"
] |
[
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Tréprostinil | Treprostinil | Treprostinilo | Treprostinilum | PGI receptor | PGI2 receptor | PRIPR | Prostaglandin I2 receptor | Prostanoid IP receptor | PGE receptor EP2 subtype | PGE2 receptor EP2 subtype | Prostanoid EP2 receptor | PGD receptor | PGD2 receptor | Prostanoid DP receptor | NR1C2 | NUC1 | NUCI | Nuclear hormone receptor 1 | Nuclear receptor subfamily 1 group C member 2 | Peroxisome proliferator-activated receptor beta | PPAR-beta | PPAR-delta | PPARB | ADP-glucose receptor | ADPG-R | HORK3 | P2T(AC) | P2Y(AC) | P2Y(ADP) | P2Y(cyc) | P2Y12 | P2Y12 platelet ADP receptor | SP1999 | 1.14.14.1 | CYPIIC8 | Cytochrome P450 form 1 | Cytochrome P450 IIC2 | Cytochrome P450 MP-12 | Cytochrome P450 MP-20 | S-mephenytoin 4-hydroxylase | (R)-limonene 6-monooxygenase | (S)-limonene 6-monooxygenase | (S)-limonene 7-monooxygenase | 1.14.14.1 | Cholesterol 25-hydroxylase | CYP2C10 | CYPIIC9 | Cytochrome P-450MP | Cytochrome P450 MP-4 | Cytochrome P450 MP-8 | Cytochrome P450 PB-1 | S-mephenytoin 4-hydroxylase
|
[
"Orenitram",
"Orenitram",
"Orenitram",
"Orenitram",
"Orenitram",
"Orenitram",
"Orenitram",
"Orenitram",
"Orenitram",
"Orenitram",
"Orenitram",
"Orenitram",
"Orenitram",
"Remodulin",
"Remodulin",
"Remodulin",
"Remodulin",
"Remodulin",
"Remodulin",
"Remodulin",
"Remodulin",
"Remodulin",
"Remodulin",
"Remodulin",
"Remodulin",
"Treprostinil",
"Treprostinil",
"Treprostinil",
"Treprostinil",
"Treprostinil",
"Treprostinil",
"Treprostinil",
"Treprostinil",
"Treprostinil",
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"Treprostinil",
"Treprostinil",
"Treprostinil",
"Treprostinil",
"Treprostinil",
"Treprostinil",
"Treprostinil",
"Treprostinil Injection",
"Treprostinil Injection",
"Treprostinil Injection",
"Treprostinil Injection",
"Trepulmix",
"Trepulmix",
"Trepulmix",
"Trepulmix",
"Tyvaso",
"Tyvaso DPI",
"Tyvaso DPI",
"Tyvaso DPI",
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"Tyvaso DPI",
"Tyvaso DPI",
"Tyvaso DPI",
"Tyvaso DPI",
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"Tyvaso DPI",
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"Tyvaso DPI",
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[] |
[
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"Tyvaso DPI",
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"Tyvaso DPI",
"Tyvaso DPI",
"Tyvaso DPI",
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"Orenitram",
"Orenitram",
"Orenitram",
"Orenitram",
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"Orenitram",
"Orenitram",
"Tyvaso DPI",
"Tyvaso DPI",
"Tyvaso DPI",
"Tyvaso DPI",
"Tyvaso DPI",
"Tyvaso DPI",
"Tyvaso DPI"
] |
[
"P43119",
"P43116",
"Q13258",
"Q03181",
"Q9H244"
] |
[
"P10632",
"P11712"
] |
[] |
[] |
DB00375
|
Colestipol
|
Bile acid sequestrants like colestipol have been in use since the 1970s.[FDA Label, F4555, F4567, L6262] And even though such an agent may very well be useful in reducing elevated cholesterol levels and decreasing the risk for atherosclerotic vascular disease due to hypercholesterolemia, colestipol is still generally only employed as an adjunct therapy and the relatively physical nature of its pharmacological activity sometimes limits its usefulness.[FDA Label, F4555, F4567, L6262]
In particular, as colestipol's general mechanism of action ultimately results in the decreased absorption and enhanced secretion of bile acids and lipids in the feces, patients who take complicated medication regimens, experience constipation or biliary obstruction, etc. may not be good candidates for using the agent owing to its physical effects on the gut.[FDA Label, F4555, F4567, L6262]
Alternatively, colestipol predominantly elicits its activities within the gut environment because it undergoes little absorption and metabolism.[FDA Label, F4555, F4567, L6262] The resultant lack of systemic exposure consequently means the medication generally demonstrates very few adverse effects inside the body.[FDA Label, F4555, F4567, L6262]
|
solid
|
Colestipol is indicated as adjunctive therapy to diet for the reduction of elevated serum total and low-density lipoprotein cholesterol (LDL-C) in patients with primary hypercholesterolemia (a condition that features elevated LDL-C) who do not respond adequately to dietary changes .[FDA Label,L6115,F4555]
Therapy with lipid-altering agents like colestipol should be a component of multiple risk factor intervention in those individuals at significantly increased risk for atherosclerotic vascular disease due to hypercholesterolemia [FDA Label, L6115, F4555]. Treatment should begin and continue with dietary therapy [FDA Label, L6115, F4555]. In general, a minimum of six months of intensive dietary therapy and counseling should be carried out prior to initiation of drug therapy such as that with colestipol [FDA Label, F4555]. Shorter periods may be considered in patients with severe elevations of LDL-C or with definite coronary heart disease [FDA Label, F4555].
Although colestipol is effective in all types of hypercholesterolemia, some regional prescribing information note in particular that it is medically most appropriate in patients with Fredrickson's type II hyperlipoproteinemia [L6115]. Nevertheless, in patients with combined hypercholesterolemia and hypertriglyceridemia, although colestipol may be helpful in reducing elevated cholesterol, it is not formally indicated where hypertriglyceridemia is the abnormality of greatest concern [F4567].
|
Cholesterol is the major, and probably the sole precursor of bile acids [FDA Label, F4555]. During normal digestion, bile acids are secreted via the bile from the liver and gall bladder into the intestines [FDA Label, F4555]. Bile acids emulsify the fat and lipid materials present in food, thus facilitating absorption [FDA Label, F4555]. A major portion of the bile acids secreted is reabsorbed from the intestines and returned via the portal circulation to the liver, thus completing the enterohepatic cycle [FDA Label, F4555]. Only very small amounts of bile acids are found in normal serum [FDA Label, F4555].
Colestipol hydrochloride binds bile acids in the intestine forming a complex that is excreted in the feces [FDA Label, F4555]. This nonsystemic action results in a partial removal of the bile acids from the enterohepatic circulation, preventing their reabsorption [FDA Label, F4555]. Since colestipol hydrochloride is an anion exchange resin, the chloride anions of the resin can be replaced by other anions, usually those with a greater affinity for the resin than the chloride ion [FDA Label, F4555].
|
Colestipol is a lipid-lowering polymer that binds with bile acids in the intestine forming a complex that is excreted in the feces [FDA Label, F4555, F4567]. This non-systemic action results in a continuous, partial removal of bile acids from the enterohepatic circulation preventing their reabsorption [FDA Label, F4555, F4567]. This increased fecal loss of bile acids due to colestipol hydrochloride administration leads to increased oxidation of cholesterol to bile acids [FDA Label, F4555, F4567]. This results in an increase in the number of hepatic low-density lipoprotein (LDL) receptors, and consequently an increased uptake of LDL and a decrease in serum/plasma beta lipoprotein or total and LDL cholesterol levels [FDA Label, F4555, F4567]. Although hydrochloride produces an increase in the hepatic synthesis of cholesterol in man, serum cholesterol levels fall [FDA Label, F4555, F4567].
|
Colestipol is hydrophilic, but it is virtually water-insoluble (99.75%) [FDA Label, L6115, F4555, F4567]. This water insolubility, combined with the high molecular weight polymer in colestipol basically means the agent and the complexes it forms when it binds with bile acids are not absorbed [FDA Label, L6115, F4555, F4567]. The action of colestipol is ultimately limited to the lumen of the gastrointestinal tract [FDA Label, L6115, F4555, F4567]. It binds bile acids in the intestinal lumen and causes them to be excreted in the feces together with the polymer [FDA Label, L6115, F4555, F4567]. When the enterohepatic circulation of bile acids is interrupted, cholesterol conversion to bile acids is enhanced and plasma cholesterol levels are thereby lowered [FDA Label, L6115, F4555, F4567].
|
Colestipol is not absorbed into the systemic circulation nor is it hydrolyzed by any digestive enzymes [FDA Label, L6115, F4555, F4567].
|
Overdosage with colestipol has not been reported [FDA Label, L6115, F4555, F4567]. Regardless, in the case of overdosage, the chief potential harm would be obstruction of the gastrointestinal tract [FDA Label, L6115, F4555, F4567]. The location of such potential obstruction, the degree of obstruction and the presence or absence of normal gut motility would determine treatment [FDA Label, L6115, F4555, F4567].
No clinical data are available on the use of colestipol in pregnant women and during lactation [FDA Label, L6115, F4555, F4567]. Colestipol does not appear to be absorbed systematically [FDA Label, L6115, F4555, F4567]. Due to its known interference with absorption of fat-soluble vitamins, the use of colestipol in pregnancy or lactation or by women of childbearing potential requires that the benefits of drug therapy be weighed against the possible hazards to the mother and the child [FDA Label, L6115, F4555, F4567].
There are no data on the effect of colestipol on fertility in humans [FDA Label, L6115, F4555, F4567].
The use of colestipol in children is limited [FDA Label, L6115, F4555, F4567]. Clinical trials conducted in children with colestipol ranules have usually employed doses of 5 to 20 g/day [FDA Label, L6115, F4555, F4567]. The National Cholesterol Education Program (NCEP) Expert Panel recommends drug therapy be considered in children 10 years or older, who have previously undergone an adequate trial of diet therapy but still have unacceptably high serum cholesterol levels [FDA Label, L6115, F4555, F4567]. In certain situations where a young child has extremely high serum cholesterol levels, drug treatment may even be initiated before 10 years of age [FDA Label, L6115, F4555, F4567]. If the child is started on drug therapy, a carefully assessed diet therapy should also be continued in order to obtain optimal results [FDA Label, L6115, F4555, F4567]. However, the safety of using colestipol tablets in patients under the age of 18 years has not been established [FDA Label, L6115, F4555, F4567]. Furthermore, because bile acid sequestrants like colestipol may interfere with the absorption of fat-soluble vitamins, appropriate monitoring of growth and development is essential if colestipol is used in children [FDA Label, L6115, F4555, F4567].
Appropriate studies on the relationship of age to the effects of colestipol have not been performed in the geriatric population [FDA Label, L6115, F4555, F4567]. However, patients over 60 years of age may be more likely to experience gastrointestinal side effects, as well as adverse nutritional effects [FDA Label, L6115, F4555, F4567].
Additionally, it has been determined that the oral LD<sub>50</sub> in rats is > 1000 mg/kg [MSDS].
|
Colestipol is not absorbed into the systemic circulation nor is it hydrolyzed by any digestive enzymes [FDA Label, L6115, F4555, F4567]. Its action is ultimately limited to the lumen of the gastrointestinal tract, where it is eventually passed into the feces [FDA Label, L6115, F4555, F4567].
|
Colestipol is not absorbed into the systemic circulation [FDA Label, L6115, F4555, F4567].
|
Colestipol hydrochloride binds bile acids in the intestine forming a complex that is then ultimately excreted in the feces [FDA Label, L6115, F4555, F4567]. In humans, less than 0.17% of a single 14C-labeled colestipol hydrochloride dose is excreted in the urine when given following 60 days of chronic dosing of 20 grams of colestipol hydrochloride per day [FDA Label, F4555]. The increased fecal loss of bile acids due to colestipol hydrochloride administration leads to increased oxidation of cholesterol to bile acids [FDA Label, F4555].
|
Colestipol is not absorbed into the systemic circulation [FDA Label, L6115, F4555, F4567].
|
Colestipol is not absorbed into the systemic circulation [FDA Label, L6115, F4555, F4567].
| null | null | null | null |
[
"approved"
] |
[
"C10AC",
"C10A",
"C10",
"C"
] |
[
"Humans and other mammals"
] |
[
{
"cost": "1.04",
"description": "Colestid 5 g Powder Packet",
"unit": "packet"
},
{
"cost": "1.04",
"description": "Colestid Orange 5 g Powder Packet",
"unit": "packet"
},
{
"cost": "3.29",
"description": "Colestid Flavored 5 gm/7.5 gm Packets",
"unit": "packet"
},
{
"cost": "81.11",
"description": "Colestid 30 5 gm Packets Box",
"unit": "box"
},
{
"cost": "252.5",
"description": "Colestid 90 5 gm Packets Box",
"unit": "box"
},
{
"cost": "0.29",
"description": "Colestid 1 g Tablet",
"unit": "tablet"
},
{
"cost": "0.3",
"description": "Colestid flavored granules",
"unit": "g"
},
{
"cost": "0.31",
"description": "Colestid Flavored 5 gm Granules",
"unit": "gm"
},
{
"cost": "0.33",
"description": "Colestid 5 gm Granules",
"unit": "gm"
},
{
"cost": "0.66",
"description": "Colestipol hcl 1 gm tablet",
"unit": "tablet"
},
{
"cost": "0.86",
"description": "Colestid 1 gm tablet",
"unit": "tablet"
}
] |
[
{
"approved": "1996-02-13",
"country": "United States",
"expires": "2013-02-13",
"number": "5490987"
}
] |
Colestipol | Colestipolum | Copolymer of bis(2-aminoethyl)amine and 2-(chloromethyl)oxirane | Epichlorohydrin-tetraethylenepentamine polymer
|
[
"Colestid",
"Colestid",
"Colestid",
"Colestid Granules",
"Colestid Orange Granules",
"Colestid Tablets",
"Colestipol Hydrochloride",
"Colestipol Hydrochloride",
"Colestipol Hydrochloride",
"Colestipol Hydrochloride",
"Colestipol Hydrochloride",
"Colestipol Hydrochloride",
"Colestipol Hydrochloride",
"Colestipol Hydrochloride",
"Colestipol Hydrochloride",
"Colestipol Hydrochloride",
"Colestipol hydrochloride",
"Colestipol hydrochloride",
"Colestipol Hydrochloride",
"Colestipol Hydrochloride",
"Colestipol Hydrochloride",
"Colestipol Hydrochloride",
"Colestipol Hydrochloride",
"Flavored Colestid",
"Flavored Colestid"
] |
[
"Cholestabyl",
"Lestid"
] |
[] |
[] |
[] |
[] |
[] |
DB00376
|
Trihexyphenidyl
|
Trihexyphenidyl is a centrally acting muscarinic antagonist used for treatment of parkinsonism and drug-induced extrapyramidal disorders.[L31773,L31778] Its discovery was published in 1949 in a study looking for drugs with antispasmodic activity.[A229103] Trihexyphenidyl is rarely used in the treatment of parkinsonism, and is not a first line treatment due to significant adverse effects.[L31843] It has largely been replaced by drugs such as [levodopa].[L31843]
Trihexyphenidyl was granted FDA approval on 13 May 1949.[L31768]
|
solid
|
Tihexyphenidyl is indicated as an adjunct in the treatment of parkinsonism, an adjuvant in the treatment of parkinsonism with levodopa, and in the control of extrapyramidal disorders caused by central nervous system drugs.[L31773,L31778]
|
Trihexyphenidyl is an antimuscarinic indicated as an adjunct in the treatment of parkinsonism or as a treatment for drug-induced extrapyramidal symptoms.[L31773,L31778] It has a long duration of action as it does not need to be given every day.[L31793] It has a wide therapeutic window, with acute toxicity being non fatal in doses as high as 300 mg.[L31793] Patients should have their iridocorneal angle examined before and intraocular pressure monitored during therapy.[L31793] Patients should be counselled regarding the risk of anhidrosis and hyperthermia.[L31793]
|
Trihexyphenidyl is a non-selective muscarinic acetylcholine receptor antagonist but binds with higher affinity to the M1 subtype.[A4716] In vivo studies have shown that trihexyphenidyl demonstrates higher affinity for central muscarinic receptors located in the cerebral cortex and lower affinity for those located peripherally.[A4716,A222363] Other studies suggest that trihexyphenidyl may modify nicotinic acetylcholine receptor neurotransmission, leading indirectly to enhanced dopamine release in the striatum.[A222373] Although the anticholinergic has proven to be useful in the treatment of symptoms associated with Parkinson’s disease or other movement disorders, its mechanism of action has yet to be fully elucidated.[A222368,A222358]
|
Trihexyphenidyl is absorbed from the gastrointestinal tract. Trihexyphenidyl reaches a C<sub>max</sub> of 7.2 ng/mL, with a T<sub>max</sub> of 1.3 hours, and an AUC of 201 ng\*h/mL.[A229078,A229088]
|
Data regarding the metabolism of trihexyphenidyl are not readily available.[A222358] However, it is likely not heavily metabolized.[A222358]
|
Symptoms of overdose include mydriasis, dryness of mucous membranes, red face, atonic states of bowels and bladder, and hyperthermia in high doses. Trihexyphenidyl causes agitation, confusion, and hallucinations due to its effects on the central nervous system. Untreated overdose may result in death, especially in children. Respiratory depression and cardiac arrest may be seen as premortal signs.
Patients experiencing an overdose of trihexyphenidyl may experience dry mouth, anhidrosis, mydriasis, nausea, vomiting, tachycardia, hyperpyrexia, reduced gastrointestinal motility, urinary hesitancy or retention, rash, hyperthermia, confusion, restlessness, agitation, poor coordination, paranoia, psychosis, delirium, hallucinations, coma, respiratory failure, circulatory failure, and death.[A222358] Patients should be treated with symptomatic and supportive care which may include airway maintenance and the use of [physostigmine].[A222358]
|
The mean elimination half life of trihexyphenidyl is 3.2 ± 0.3 hours.[A229078]
|
Data regarding the extent of trihexyphenidyl protein binding in plasma are not readily available. Trihexyphenidyl is 36.13-41.92% bound to albumin under controlled conditions in a dialysis bag.[A229068]
|
Data regarding the route of elimination of trihexyphenidyl are not readily available.[A222358] However, it is likely eliminated predominantly in the urine.[A222358]
| null | null |
Organic compounds
|
Organic nitrogen compounds
|
Organonitrogen compounds
|
Amines
|
[
"approved"
] |
[
"N04AA",
"N04A",
"N04",
"N"
] |
[
"Humans and other mammals"
] |
[
{
"cost": "0.04",
"description": "Apo-Trihex 2 mg Tablet",
"unit": "tablet"
},
{
"cost": "0.07",
"description": "Apo-Trihex 5 mg Tablet",
"unit": "tablet"
},
{
"cost": "0.18",
"description": "Trihexyphenidyl 2 mg tablet",
"unit": "tablet"
},
{
"cost": "0.26",
"description": "Trihexyphenidyl HCl 2 mg tablet",
"unit": "tablet"
},
{
"cost": "0.36",
"description": "Trihexyphenidyl 5 mg tablet",
"unit": "tablet"
},
{
"cost": "0.37",
"description": "Trihexyphenidyl HCl 5 mg tablet",
"unit": "tablet"
}
] |
[] |
Trihexifenidilo | Trihexyphenidyl | Trihexyphénidyle | Trihexyphenidylum | ADRB3R | B3AR | Beta-3 adrenoceptor | Beta-3 adrenoreceptor
|
[
"Aparkane Tab 2mg",
"Aparkane Tab 5mg",
"Artane Elx 2mg/5ml",
"Artane Tab 2mg",
"Artane Tab 5mg",
"Novo-hexidyl 2mg",
"Novo-hexidyl 5mg",
"Nu-trihexyphenidyl",
"Nu-trihexyphenidyl",
"PMS Trihexyphenidyl",
"PMS-trihexyphenidyl",
"PMS-trihexyphenidyl Elx 0.4mg/ml",
"Trihexyphen 5 Tab 5mg",
"Trihexyphen Tab 2mg",
"Trihexyphenidyl",
"Trihexyphenidyl",
"Trihexyphenidyl hydrochloride",
"Trihexyphenidyl hydrochloride",
"Trihexyphenidyl Hydrochloride",
"Trihexyphenidyl Hydrochloride",
"Trihexyphenidyl Hydrochloride",
"Trihexyphenidyl Hydrochloride",
"Trihexyphenidyl Hydrochloride",
"Trihexyphenidyl Hydrochloride",
"Trihexyphenidyl Hydrochloride",
"Trihexyphenidyl Hydrochloride",
"Trihexyphenidyl Hydrochloride",
"Trihexyphenidyl Hydrochloride",
"Trihexyphenidyl Hydrochloride",
"Trihexyphenidyl Hydrochloride",
"Trihexyphenidyl Hydrochloride",
"Trihexyphenidyl Hydrochloride",
"Trihexyphenidyl Hydrochloride",
"Trihexyphenidyl Hydrochloride",
"Trihexyphenidyl Hydrochloride",
"Trihexyphenidyl Hydrochloride",
"Trihexyphenidyl Hydrochloride",
"Trihexyphenidyl Hydrochloride",
"Trihexyphenidyl Hydrochloride",
"Trihexyphenidyl Hydrochloride",
"Trihexyphenidyl Hydrochloride",
"Trihexyphenidyl Hydrochloride",
"Trihexyphenidyl Hydrochloride",
"Trihexyphenidyl Hydrochloride",
"Trihexyphenidyl Hydrochloride",
"Trihexyphenidyl Hydrochloride",
"Trihexyphenidyl Hydrochloride",
"Trihexyphenidyl Hydrochloride",
"Trihexyphenidyl Hydrochloride",
"Trihexyphenidyl Hydrochloride",
"Trihexyphenidyl Hydrochloride",
"Trihexyphenidyl Hydrochloride",
"Trihexyphenidyl Hydrochloride",
"Trihexyphenidyl Hydrochloride",
"Trihexyphenidyl Hydrochloride",
"Trihexyphenidyl Hydrochloride",
"Trihexyphenidyl Hydrochloride",
"Trihexyphenidyl Hydrochloride",
"Trihexyphenidyl Hydrochloride",
"Trihexyphenidyl Hydrochloride",
"Trihexyphenidyl Hydrochloride",
"Trihexyphenidyl Hydrochloride",
"Trihexyphenidyl Hydrochloride",
"Trihexyphenidyl Hydrochloride",
"Trihexyphenidyl Hydrochloride",
"Trihexyphenidyl Hydrochloride",
"Trihexyphenidyl Hydrochloride",
"Trihexyphenidyl Hydrochloride",
"Trihexyphenidyl Hydrochloride",
"Trihexyphenidyl Hydrochloride",
"Trihexyphenidyl Hydrochloride",
"Trihexyphenidyl Hydrochloride",
"Trihexyphenidyl Hydrochloride",
"Trihexyphenidyl Hydrochloride",
"Trihexyphenidyl Hydrochloride",
"Trihexyphenidyl Hydrochloride",
"Trihexyphenidyl Hydrochloride",
"Trihexyphenidyl Hydrochloride",
"Trihexyphenidyl Hydrochloride",
"Trihexyphenidyl Hydrochloride",
"Trihexyphenidyl Hydrochloride",
"Trihexyphenidyl Hydrochloride",
"Trihexyphenidyl Hydrochloride",
"Trihexyphenidyl Hydrochloride",
"Trihexyphenidyl Hydrochloride",
"Trihexyphenidyl Hydrochloride",
"Trihexyphenidyl Hydrochloride"
] |
[
"ACA",
"Acamed",
"Altant",
"Apo-trihex",
"Artane",
"Artine",
"Atan",
"Benzhexol",
"Benzox",
"Bexol",
"Broflex",
"Cyclodol",
"Dyskinil",
"Ea Ten",
"Hexymer",
"Hipokinon",
"Lahexy",
"Pacitane",
"Pakisonal",
"Parales",
"Parcisol",
"Pargitan",
"Parkin",
"Parkinane",
"Parkines",
"Parkinidyl",
"Parkisan",
"Parkitane",
"Parkizol",
"Tonaril"
] |
[] |
[
"P11229",
"P13945",
"P08172",
"P20309",
"P08173",
"P08912"
] |
[] |
[
"P02768"
] |
[] |
DB00377
|
Palonosetron
|
Palonosetron (INN, trade name Aloxi) is an antagonist of 5-HT3 receptors that is indicated for the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). It is the most effective of the 5-HT3 antagonists in controlling delayed CINV nausea and vomiting that appear more than 24 hours after the first dose of a course of chemotherapy and is the only drug of its class approved for this use by the U.S. Food and Drug Administration. As of 2008, it is the most recent 5-HT3 antagonist to enter clinical use.
|
solid
|
For the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of moderately emetogenic cancer chemotherapy, as well as prevention of acute nausea and vomiting associated with highly emetogenic cancer chemotherapy. Also used for the prevention of postoperative nausea and vomiting for up to 24 hours post operation.
|
Palonosetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting. Palonosetron is a highly specific and selective serotonin 5-HT<sub>3</sub> receptor antagonist that is pharmacologically related to other 5-HT<sub>3</sub> receptor antagonists, but differs structurally. Palonosetron has a high affinity for 5-HT<sub>3</sub> receptors, but has little to no affinity for other receptors. The serontonin 5-HT<sub>3</sub> receptors are located on the nerve terminals of the vagus in the periphery, and centrally in the chemoreceptor trigger zone of the area postrema. It is suggested that chemotherapeutic agents release serotonin from the enterochromaffin cells of the small intestine by causing degenerative changes in the GI tract. The serotonin then stimulates the vagal and splanchnic nerve receptors that project to the medullary vomiting center, as well as the 5-HT3 receptors in the area postrema, thus initiating the vomiting reflex, causing nausea and vomiting.
|
Palonosetron is a selective serotonin 5-HT<sub>3</sub> receptor antagonist. The antiemetic activity of the drug is brought about through the inhibition of 5-HT<sub>3</sub> receptors present both centrally (medullary chemoreceptor zone) and peripherally (GI tract). This inhibition of 5-HT<sub>3</sub> receptors in turn inhibits the visceral afferent stimulation of the vomiting center, likely indirectly at the level of the area postrema, as well as through direct inhibition of serotonin activity within the area postrema and the chemoreceptor trigger zone. Alternative mechanisms appear to be primarily responsible for delayed nausea and vomiting induced by emetogenic chemotherapy, since similar temporal relationships between between serotonin and emesis beyond the first day after a dose have not been established, and 5-HT<sub>3</sub> receptor antagonists generally have not appeared to be effective alone in preventing or ameliorating delayed effects. It has been hypothesized that palonosetron's potency and long plasma half-life may contribute to its observed efficacy in preventing delayed nausea and vomiting caused by moderately emetogenic cancer chemotherapy.
|
Low oral bioavailability.
|
Hepatic (50%), primarily CYP2D6-mediated, although CYP3A4 and CYP1A2 are also involved.
|
A single intravenous dose of palonosetron at 30 mg/kg (947 and 474 times the human dose for rats and mice, respectively, based on body surface area) was lethal to rats and mice. The major signs of toxicity were convulsions, gasping, pallor, cyanosis and collapse.
|
Approximately 40 hours
|
62%
|
After a single intravenous dose of 10 mcg/kg [14C]-palonosetron, approximately 80% of the dose was recovered within 144 hours in the urine
|
* 8.3 ± 2.5 L/kg
|
* 160 +/- 35 mL/h/kg
|
Organic compounds
|
Organoheterocyclic compounds
|
Isoquinolines and derivatives
|
Isoquinolones and derivatives
|
[
"approved",
"investigational"
] |
[
"A04AA",
"A04A",
"A04",
"A",
"A04AA",
"A04A",
"A04",
"A"
] |
[
"Humans and other mammals"
] |
[
{
"cost": "52.8",
"description": "Aloxi 0.075 mg/1.5 ml vial",
"unit": "ml"
}
] |
[
{
"approved": "2015-09-08",
"country": "United States",
"expires": "2024-07-30",
"number": "9125905"
},
{
"approved": "2013-08-27",
"country": "United States",
"expires": "2024-07-30",
"number": "8518981"
},
{
"approved": "2011-05-24",
"country": "United States",
"expires": "2024-07-30",
"number": "7947725"
},
{
"approved": "2013-12-03",
"country": "United States",
"expires": "2024-07-30",
"number": "8598218"
},
{
"approved": "2011-06-14",
"country": "United States",
"expires": "2024-07-30",
"number": "7960424"
},
{
"approved": "2015-11-03",
"country": "United States",
"expires": "2024-07-30",
"number": "9173942"
},
{
"approved": "2011-05-24",
"country": "United States",
"expires": "2024-07-30",
"number": "7947724"
},
{
"approved": "2013-12-03",
"country": "United States",
"expires": "2024-07-30",
"number": "8598219"
},
{
"approved": "2014-05-20",
"country": "United States",
"expires": "2024-07-30",
"number": "8729094"
},
{
"approved": "2015-06-30",
"country": "United States",
"expires": "2024-07-30",
"number": "9066980"
},
{
"approved": "2015-11-17",
"country": "United States",
"expires": "2030-11-18",
"number": "9186357"
},
{
"approved": "2014-01-07",
"country": "United States",
"expires": "2030-11-18",
"number": "8623826"
},
{
"approved": "2015-02-10",
"country": "United States",
"expires": "2030-11-18",
"number": "8951969"
},
{
"approved": "2001-10-02",
"country": "United States",
"expires": "2020-02-22",
"number": "6297375"
},
{
"approved": "1993-04-13",
"country": "United States",
"expires": "2015-10-13",
"number": "5202333"
},
{
"approved": "2016-10-04",
"country": "United States",
"expires": "2024-07-30",
"number": "9457020"
},
{
"approved": "2016-09-13",
"country": "United States",
"expires": "2024-07-30",
"number": "9439854"
},
{
"approved": "2016-10-04",
"country": "United States",
"expires": "2024-07-30",
"number": "9457021"
},
{
"approved": "2016-03-01",
"country": "United States",
"expires": "2031-09-09",
"number": "9271975"
},
{
"approved": "2018-04-17",
"country": "United States",
"expires": "2030-11-18",
"number": "9943515"
},
{
"approved": "2016-08-02",
"country": "United States",
"expires": "2032-05-23",
"number": "9403772"
},
{
"approved": "2014-11-25",
"country": "United States",
"expires": "2032-05-23",
"number": "8895586"
},
{
"approved": "2018-03-06",
"country": "United States",
"expires": "2032-05-23",
"number": "9908907"
},
{
"approved": "2018-04-24",
"country": "United States",
"expires": "2035-09-25",
"number": "9951016"
},
{
"approved": "2013-04-23",
"country": "United States",
"expires": "2032-05-23",
"number": "8426450"
},
{
"approved": "2019-02-19",
"country": "United States",
"expires": "2032-05-23",
"number": "10208073"
},
{
"approved": "2019-03-19",
"country": "United States",
"expires": "2035-09-25",
"number": "10233154"
},
{
"approved": "2020-04-21",
"country": "United States",
"expires": "2037-06-02",
"number": "10624911"
},
{
"approved": "2020-06-09",
"country": "United States",
"expires": "2035-09-25",
"number": "10676440"
},
{
"approved": "2020-07-21",
"country": "United States",
"expires": "2032-05-23",
"number": "10717721"
},
{
"approved": "2020-11-10",
"country": "United States",
"expires": "2030-12-17",
"number": "10828297"
},
{
"approved": "2021-03-30",
"country": "United States",
"expires": "2035-09-25",
"number": "10961195"
},
{
"approved": "2012-05-23",
"country": "United States",
"expires": "2032-05-23",
"number": "11312698"
},
{
"approved": "2017-06-02",
"country": "United States",
"expires": "2037-06-02",
"number": "11529362"
},
{
"approved": "2010-11-18",
"country": "United States",
"expires": "2030-11-18",
"number": "11559523"
},
{
"approved": "2010-11-18",
"country": "United States",
"expires": "2030-11-18",
"number": "12042494"
}
] |
(3aS)-2-[(3S)-1-azabicyclo[2.2.2]octan-3-yl]-2,3,3a,4,5,6-hexahydro-1H-benzo[de]isoquinolin-1-one | 2-(1-Azabicyclo(2.2.2)oct-3-yl)-2,3,3a,4,5,6-hexahydro-1H-benz(de)isoquinolin-1-one | Palonosetron | Palonosétron | Palonosetrón | Palonosetronum | 5-HT-3 | 5-HT3-A | 5-HT3A | 5-HT3R | 5-hydroxytryptamine receptor 3 | 5HT3R | HTR3 | Serotonin receptor 3A | Serotonin-gated ion channel receptor | 1.14.14.- | Cholesterol 25-hydroxylase | CYP2DL1 | CYPIID6 | Cytochrome P450-DB1 | Debrisoquine 4-hydroxylase | 1,4-cineole 2-exo-monooxygenase | 1,8-cineole 2-exo-monooxygenase | 1.14.14.1 | Albendazole monooxygenase (sulfoxide-forming) | Albendazole sulfoxidase | Cholesterol 25-hydroxylase | CYP3A3 | CYPIIIA3 | CYPIIIA4 | Cytochrome P450 3A3 | Cytochrome P450 HLp | Cytochrome P450 NF-25 | Cytochrome P450-PCN1 | Nifedipine oxidase | Quinine 3-monooxygenase | 1.14.14.1 | Cholesterol 25-hydroxylase | CYPIA2 | Cytochrome P(3)450 | Cytochrome P450 4 | Cytochrome P450-P3 | Hydroperoxy icosatetraenoate dehydratase
|
[
"Akynzeo",
"Akynzeo",
"Akynzeo",
"Akynzeo",
"Akynzeo",
"Akynzeo",
"Akynzeo",
"Akynzeo",
"Akynzeo",
"Akynzeo",
"Aloxi",
"Aloxi",
"Aloxi",
"Aloxi",
"Aloxi",
"Aloxi",
"Aloxi",
"Aloxi",
"Aloxi",
"Aloxi",
"Aloxi",
"Palonosetron",
"Palonosetron",
"Palonosetron",
"Palonosetron",
"Palonosetron",
"Palonosetron",
"Palonosetron",
"Palonosetron",
"Palonosetron",
"Palonosetron Accord",
"Palonosetron Hospira",
"Palonosetron Hydrochloride",
"Palonosetron Hydrochloride",
"Palonosetron Hydrochloride",
"Palonosetron Hydrochloride",
"Palonosetron Hydrochloride",
"Palonosetron Hydrochloride",
"Palonosetron Hydrochloride",
"Palonosetron Hydrochloride",
"Palonosetron Hydrochloride",
"Palonosetron Hydrochloride",
"Palonosetron hydrochloride",
"Palonosetron hydrochloride",
"Palonosetron Hydrochloride",
"Palonosetron Hydrochloride",
"Palonosetron Hydrochloride",
"Palonosetron Hydrochloride",
"Palonosetron Hydrochloride",
"Palonosetron Hydrochloride",
"Palonosetron Hydrochloride",
"Palonosetron Hydrochloride",
"Palonosetron Hydrochloride",
"Palonosetron Hydrochloride",
"Posfrea",
"Posfrea"
] |
[
"Jiouting",
"Onicit",
"Palnox",
"Paloxi",
"Palzen",
"Themiset",
"Zhiruo"
] |
[
"Akynzeo",
"Akynzeo",
"Akynzeo",
"Akynzeo",
"Akynzeo",
"Akynzeo",
"Akynzeo",
"Akynzeo",
"Akynzeo",
"Akynzeo"
] |
[
"P46098"
] |
[
"P10635",
"P08684",
"P05177"
] |
[] |
[] |
DB00378
|
Dydrogesterone
|
A synthetic progestational hormone with no androgenic or estrogenic properties. Unlike many other progestational compounds, dydrogesterone produces no increase in temperature and does not inhibit ovulation.
|
solid
|
Used to treat irregular duration of cycles and irregular occurrence and duration of periods caused by progesterone deficiency. Also used to prevent natural abortion in patients who have a history of habitual abortions.
|
Dydrogesterone is an orally active progestogen which acts directly on the uterus, producing a complete secretory endometrium in an estrogen-primed uterus. At therapeutic levels, dydrogesterone has no contraceptive effect as it does not inhibit or interfere with ovulation or the corpus luteum. Furthermore, dydrogesterone is non-androgenic, non-estrogenic, non-corticoid, non-anabolic and is not excreted as pregnanediol. Dydrogesterone helps to regulate the healthy growth and normal shedding of the uterus lining. Therefore, it may be useful in the treatment of menstrual disorders such as absent, irregular or painful menstrual periods, infertility, premenstrual syndrome and endometriosis.
|
Dydrogesterone is a progestogen that works by regulating the healthy growth and normal shedding of the womb lining by acting on progesterone receptors in the uterus.
|
Rapidly absorbed in the gastrointestinal tract with a bioavailability of 28%.
|
Metabolism is complete to a 20-dihydrodydrogesterone (DHD) metabolite.
|
No serious or unexpected toxicity has been observed with dydrogesterone. In acute toxicity studies, the LD50 doses in rats exceeded 4,640mg/kg for the oral route.
|
Dydrogesterone: 5-7 hours, 20-dihydrodydrogesterone (DHD) metabolite: 14-17 hours
| null | null | null | null |
Organic compounds
|
Lipids and lipid-like molecules
|
Steroids and steroid derivatives
|
Pregnane steroids
|
[
"approved",
"investigational",
"withdrawn"
] |
[
"G03FA",
"G03F",
"G03",
"G",
"G03DB",
"G03D",
"G03",
"G",
"G03FB",
"G03F",
"G03",
"G"
] |
[
"Humans and other mammals"
] |
[] |
[] |
(9β,10α)-pregna-4,6-diene-3,20-dione | 10α-Isopregnenone | 6-Dehydro-retro-progesterone | 9β,10α-pregna-4,6-diene-3,20-dione | delta(6)-Retroprogesterone | delta(sup 6)-Retroprogesterone | Didrogesterona | Didrogesterone | Dydrogesterona | Dydrogestérone | Dydrogesterone | Dydrogesteronum | Gestatron | Hydrogesterone | Hydrogestrone | Isopregnenone | Retro-6-dehydroprogesterone | NR3C3 | Nuclear receptor subfamily 3 group C member 3 | PR | 1,4-cineole 2-exo-monooxygenase | 1,8-cineole 2-exo-monooxygenase | 1.14.14.1 | Albendazole monooxygenase (sulfoxide-forming) | Albendazole sulfoxidase | Cholesterol 25-hydroxylase | CYP3A3 | CYPIIIA3 | CYPIIIA4 | Cytochrome P450 3A3 | Cytochrome P450 HLp | Cytochrome P450 NF-25 | Cytochrome P450-PCN1 | Nifedipine oxidase | Quinine 3-monooxygenase
|
[] |
[
"Dabroston",
"Dufaston",
"Duphaston",
"Terolut"
] |
[] |
[
"P06401"
] |
[
"P08684"
] |
[] |
[] |
DB00379
|
Mexiletine
|
Antiarrhythmic agent pharmacologically similar to lidocaine. It may have some anticonvulsant properties.
|
solid
|
For the treatment of ventricular tachycardia and symptomatic premature ventricular beats, and prevention of ventricular fibrillation.
|
Mexiletine is a local anesthetic, antiarrhythmic agent (Class Ib), structurally similar to lidocaine, but orally active. Mexiletine has fast onset and offset kinetics, meaning that they have little or no effect at slower heart rates, and more effects at faster heart rates. It shortens the action potential duration, reduces refractoriness, and decreases Vmax in partially depolarized cells with fast response action potentials. Mexiletine either does not change the action potential duration, or decreases the action potential duration.
|
Mexiletine, like lidocaine, inhibits the inward sodium current required for the initiation and conduction of impulses, thus reducing the rate of rise of the action potential, Phase 0. It achieves this reduced sodium current by inhibiting sodium channels. Mexiletine decreases the effective refractory period (ERP) in Purkinje fibers in the heart. The decrease in ERP is of lesser magnitude than the decrease in action potential duration (APD), which results in an increase in the ERP/APD ratio. It does not significantly affect resting membrane potential or sinus node automaticity, left ventricular function, systolic arterial blood pressure, atrioventricular (AV) conduction velocity, or QRS or QT intervals
|
Well absorbed (bioavailability 90%) from the gastrointenstinal tract.
|
Primarily hepatic (85%) via CYP2D6 and CYP1A2 (primarily CYP2D6).
|
Symptoms of overdose include nausea, hypotension, sinus bradycardia, paresthesia, seizures, bundle branch block, AV heart block, asystole, ventricular tachyarrythmia, including ventricular fibrillation, cardiovascular collapse, and coma.
|
10-12 hours
|
50-60%
|
Approximately 10% is excreted unchanged by the kidney. The urinary excretion of N-methylmexiletine in man is less than 0.5%.
|
* 5 to 7 L/lg
| null |
Organic compounds
|
Benzenoids
|
Phenol ethers
| null |
[
"approved",
"investigational"
] |
[
"C01BB",
"C01B",
"C01",
"C"
] |
[
"Humans and other mammals"
] |
[
{
"cost": "1.11",
"description": "Mexiletine 150 mg capsule",
"unit": "capsule"
},
{
"cost": "1.16",
"description": "Mexiletine HCl 150 mg capsule",
"unit": "capsule"
},
{
"cost": "1.19",
"description": "Novo-Mexiletine 200 mg Capsule",
"unit": "capsule"
},
{
"cost": "1.23",
"description": "Mexitil 200 mg capsule",
"unit": "capsule"
},
{
"cost": "1.33",
"description": "Mexiletine 200 mg capsule",
"unit": "capsule"
},
{
"cost": "1.38",
"description": "Mexiletine HCl 200 mg capsule",
"unit": "capsule"
},
{
"cost": "1.54",
"description": "Mexiletine 250 mg capsule",
"unit": "capsule"
},
{
"cost": "1.6",
"description": "Mexiletine HCl 250 mg capsule",
"unit": "capsule"
},
{
"cost": "1.85",
"description": "Mexitil 250 mg capsule",
"unit": "capsule"
},
{
"cost": "0.89",
"description": "Novo-Mexiletine 100 mg Capsule",
"unit": "capsule"
}
] |
[] |
(±)-1-(2,6-dimethylphenoxy)propan-2-amine | (2RS)-1-(2,6-dimethylphenoxy)-2-aminopropane | 1-(2,6-dimethylphenoxy)-2-propanamine | 1-(2',6'-dimethylphenoxy)-2-aminopropane | 1-methyl-2-(2,6-xylyloxy)ethanamine | Mexiletina | Mexiletine | Mexilétine | Mexiletinum | hH1 | Sodium channel protein cardiac muscle subunit alpha | Sodium channel protein type V subunit alpha | Voltage-gated sodium channel subunit alpha Nav1.5 | Ah receptor | AhR | BHLHE76 | Class E basic helix-loop-helix protein 76 | 1,4-cineole 2-exo-monooxygenase | 1.14.13.- | CYPIIB6 | Cytochrome P450 IIB1 | 1.14.14.1 | 4-nitrophenol 2-hydroxylase | CYP2E | CYPIIE1 | Cytochrome P450-J | 1,4-cineole 2-exo-monooxygenase | 1,8-cineole 2-exo-monooxygenase | 1.14.14.1 | Albendazole monooxygenase (sulfoxide-forming) | Albendazole sulfoxidase | Cholesterol 25-hydroxylase | CYP3A3 | CYPIIIA3 | CYPIIIA4 | Cytochrome P450 3A3 | Cytochrome P450 HLp | Cytochrome P450 NF-25 | Cytochrome P450-PCN1 | Nifedipine oxidase | Quinine 3-monooxygenase | 1.14.14.1 | Cholesterol 25-hydroxylase | CYPIA2 | Cytochrome P(3)450 | Cytochrome P450 4 | Cytochrome P450-P3 | Hydroperoxy icosatetraenoate dehydratase | 1.14.14.- | Cholesterol 25-hydroxylase | CYP2DL1 | CYPIID6 | Cytochrome P450-DB1 | Debrisoquine 4-hydroxylase
|
[
"Alti-mexiletine",
"Alti-mexiletine",
"Mexiletine HCl",
"Mexiletine HCl",
"Mexiletine HCl",
"Mexiletine Hydrochloride",
"Mexiletine Hydrochloride",
"Mexiletine Hydrochloride",
"Mexiletine Hydrochloride",
"Mexiletine Hydrochloride",
"Mexiletine Hydrochloride",
"Mexiletine Hydrochloride",
"Mexiletine Hydrochloride",
"Mexiletine Hydrochloride",
"Mexiletine Hydrochloride",
"Mexiletine Hydrochloride",
"Mexiletine Hydrochloride",
"Mexiletine Hydrochloride",
"Mexiletine Hydrochloride",
"Mexiletine Hydrochloride",
"Mexiletine Hydrochloride",
"Mexiletine Hydrochloride",
"Mexiletine Hydrochloride",
"Mexiletine Hydrochloride",
"Mexiletine Hydrochloride",
"Mexiletine Hydrochloride",
"Mexiletine Hydrochloride",
"Mexiletine Hydrochloride",
"Mexiletine Hydrochloride",
"Mexiletine Hydrochloride",
"Mexiletine Hydrochloride",
"Mexiletine Hydrochloride",
"Mexiletine Hydrochloride",
"Mexiletine Hydrochloride",
"Mexiletine Hydrochloride",
"Mexiletine Hydrochloride",
"Mexiletine Hydrochloride",
"Mexiletine Hydrochloride",
"Mexiletine Hydrochloride",
"Mexiletine Hydrochloride",
"Mexiletine Hydrochloride",
"Mexiletine Hydrochloride",
"Mexiletine Hydrochloride",
"Mexiletine Hydrochloride",
"Mexiletine Hydrochloride",
"Mexiletine Hydrochloride",
"Mexiletine hydrochloride",
"Mexiletine hydrochloride",
"Mexiletine hydrochloride",
"Mexiletine Hydrochloride",
"Mexiletine Hydrochloride",
"Mexiletine Hydrochloride",
"Mexiletine Hydrochloride",
"Mexiletine Hydrochloride",
"Mexiletine Hydrochloride",
"Mexiletine Hydrochloride",
"Mexiletine hydrochloride",
"Mexiletine Hydrochloride",
"Mexiletine Hydrochloride",
"Mexiletine Hydrochloride",
"Mexitil",
"Mexitil",
"Mexitil",
"Mexitil",
"Mexitil",
"Mexitil Cap 100mg",
"Mexitil Cap 200mg",
"Mint-mexiletine",
"Mint-mexiletine",
"Namuscla",
"Namuscla",
"Namuscla",
"Namuscla",
"Teva-mexiletine",
"Teva-mexiletine"
] |
[
"Cirumimeru",
"Mekiratin",
"Melate",
"Meldest",
"Meletin",
"Mequitolide",
"Metorekicin",
"Mexicord",
"Mexitilen",
"Minsetil",
"Mobalen",
"Mugadine",
"Olzoron",
"Poeruten",
"Ritalmex",
"Toi",
"Tumetil"
] |
[] |
[
"Q14524",
"P35869"
] |
[
"P20813",
"P05181",
"P08684",
"P05177",
"P10635"
] |
[] |
[] |
DB00380
|
Dexrazoxane
|
An antimitotic agent with immunosuppressive properties. Dexrazoxane, the (+)-enantiomorph of razoxane, provides cardioprotection against anthracycline toxicity. It appears to inhibit formation of a toxic iron-anthracycline complex. [PubChem]
The Food and Drug Administration has designated dexrazoxane as an orphan drug for use in the prevention or reduction in the incidence and severity of anthracycline-induced cardiomyopathy.
|
solid
|
For reducing the incidence and severity of cardiomyopathy associated with doxorubicin administration in women with metastatic breast cancer who have received a cumulative doxorubicin hydrochloride dose of 300 mg/m^2 and would benefit from continued doxorubicin therapy. Also approved for the treatment of extravasation from intravenous anthracyclines.
|
Dexrazoxane is a cardioprotective agent for use in conjunction with doxorubicin indicated for reducing the incidence and severity of cardiomyopathy associated with doxorubicin administration in women with metastatic breast cancer who have received a cumulative doxorubicin dose. Patients receiving anthracycline-derivative antineoplastic agents may experience three types of cardiotoxicity: acute transient type; chronic, subacute type (related to cumulative dose and has a more indolent onset later on); and a late-onset type that manifests years after therapy, mainly in patients that have been exposed to the drug as a child. Although the exact mechanism of anthracycline-induced cardiotoxicity is not known, it has shown to exert a variety of actions that may result in the development of cardiotoxicity. In animals, anthracyclines cause a selective inhibition of cardiac muscle gene expression for α-actin, troponin, myosin light-chain 2, and the M isoform of creatine kinase. This may lead to myofibrillar loss associated with anthracycline-induced cardiotoxicity. Anthracyclines may also cause myocyte damage via calcium overload, altered myocardial adrenergic function, release of vasoactive amines, and proinflammatory cytokines. Furthermore, it has been suggested that the main cause of anthracycline-induced cardiotoxicity is associated with free-radical damage to DNA. The drugs intercalate DNA, chelate metal ions to produce drug-metal complexes, and generate superoxide radicals via oxidation-reduction reactions. Anthracyclines also contain a quinone structure that can undergo reduction via NADPH-dependent reactions to produce a semiquinone free radical that initiates a cascade of superoxide and hydroxide radical generation. Chelation of metal ions, particularly iron, by anthracyclines results in an anthracycline-metal complex that catalyzes the generation of reactive oxygen free radicals. This complex is a powerful oxidant that can initiate lipid peroxidation in the absence of oxygen free radicals. The toxicity induced by antrhacyclines may be exacerbated in cardiac cells, as these cells do not possess sufficient amounts of certain enzymes (e.g., superoxide dismutase, catalase, glutathione peroxidase) involved in detoxifying free radicals and protecting the cells from subsequent damage.
|
The mechanism by which dexrazoxane exerts its cardioprotective activity is not fully understood. Dexrazoxane is a cyclic derivative of EDTA that readily penetrates cell membranes. Results of laboratory studies suggest that dexrazoxane (a prodrug) is converted intracellularly to a ring-opened bidentate chelating agent that chelates to free iron and interferes with iron-mediated free radical generation thought to be responsible, in part, for anthracycline-induced cardiomyopathy. It should be noted that dexrazoxane may also be protective through its inhibitory effect on topoisomerase II.
|
IV administration results in complete bioavailability.
|
Dexrazoxane is hydrolysed by the enzyme dihydropyrimidine amidohydrolase in the liver and kidney to active metabolites that are capable of binding to metal ions.
|
Intraperitoneal, mouse LD<sub>10</sub> = 500 mg/kg. Intravenous, dog LD<sub>10</sub> = 2 gm/kg.
|
2.5 hours
|
Very low (< 2%)
|
Urinary excretion plays an important role in the elimination of dexrazoxane. Forty-two percent of the 500 mg/m2 dose of dexrazoxane was excreted in the urine.
|
* 9 to 22.6 L/m^2
|
* 7.88 L/h/m2 [dose of 50 mg/m2 Doxorubicin and 500 mg/m2 Dexrazoxane]
* 6.25 L/h/m2 [dose of 60 mg/m2 Doxorubicin and 600 mg/m2 Dexrazoxane]
|
Organic compounds
|
Organic acids and derivatives
|
Carboxylic acids and derivatives
|
Amino acids, peptides, and analogues
|
[
"approved",
"withdrawn"
] |
[
"V03AF",
"V03A",
"V03",
"V"
] |
[
"Humans and other mammals"
] |
[
{
"cost": "246.28",
"description": "Dexrazoxane 250 mg vial",
"unit": "vial"
},
{
"cost": "258.59",
"description": "Zinecard 250 mg vial",
"unit": "vial"
},
{
"cost": "492.55",
"description": "Dexrazoxane 500 mg vial",
"unit": "vial"
},
{
"cost": "517.18",
"description": "Zinecard 500 mg vial",
"unit": "vial"
}
] |
[
{
"approved": "1993-09-07",
"country": "United States",
"expires": "2010-09-07",
"number": "5242901"
},
{
"approved": "2004-04-27",
"country": "United States",
"expires": "2020-03-13",
"number": "6727253"
}
] |
(+)-(S)-4,4'-Propylenedi-2,6-piperazinedione | (+)-1,2-Bis(3,5-dioxo-1-piperazinyl)propane | 4-[(2S)-2-(3,5-dioxopiperazin-1-yl)propyl]piperazine-2,6-dione | Dexrazoxan | Dexrazoxane | Dexrazoxano | Dexrazoxanum | Dextrorazoxane | 5.6.2.2 | DNA topoisomerase II, alpha isozyme | TOP2 | 5.6.2.2 | DNA topoisomerase II, beta isozyme
|
[
"Cardioxane",
"Dexrazoxane",
"Dexrazoxane",
"Dexrazoxane",
"Dexrazoxane",
"Dexrazoxane",
"Dexrazoxane",
"Dexrazoxane",
"Dexrazoxane",
"Dexrazoxane",
"Dexrazoxane",
"Dexrazoxane",
"Dexrazoxane",
"Dexrazoxane",
"Dexrazoxane for Injection",
"Dexrazoxane for Injection",
"Dexrazoxane Hydrochloride",
"Dexrazoxane Hydrochloride",
"Savene",
"Totect",
"Totect",
"Totect",
"Zinecard",
"Zinecard",
"Zinecard",
"Zinecard",
"Zinecard",
"Zinecard"
] |
[
"Ao Nuo Xian",
"Cardioxane"
] |
[] |
[
"P11388",
"Q02880"
] |
[] |
[] |
[] |
DB00381
|
Amlodipine
|
Amlodipine, initially approved by the FDA in 1987, is a popular antihypertensive drug belonging to the group of drugs called _dihydropyridine calcium channel blockers_. Due to their selectivity for the peripheral blood vessels, dihydropyridine calcium channel blockers are associated with a lower incidence of myocardial depression and cardiac conduction abnormalities than other calcium channel blockers [A175327].
Amlodipine is commonly used in the treatment of high blood pressure and angina. Amlodipine has antioxidant properties and an ability to enhance the production of nitric oxide (NO), an important vasodilator that decreases blood pressure [A175321]. The option for single daily dosing of amlodipine is an attractive feature of this drug [FDA label].
|
solid
|
Amlodipine may be used alone or in combination with other antihypertensive and antianginal agents for the treatment of the following conditions [FDA label]:
• Hypertension
• Coronary artery disease
• Chronic stable angina
• Vasospastic angina (Prinzmetal’s or Variant angina)
• Angiographically documented coronary artery disease in patients without heart failure or an ejection fraction < 40%
|
**General pharmacodynamic effects**
Amlodipine has a strong affinity for cell membranes, modulating calcium influx by inhibiting selected membrane calcium channels. This drug's unique binding properties allow for its long-acting action and less frequent dosing regimen [A573], [FDA label].
**Hemodynamic effects**
After the administration of therapeutic doses of amlodipine to patients diagnosed with hypertension, amlodipine causes vasodilation, which results in a reduction of supine and standing blood pressure. During these blood pressure reductions, there are no clinically significant changes in heart rate or plasma catecholamine levels with long-term use. Acute intravenous administration of amlodipine reduces arterial blood pressure and increases heart rate in patients with chronic stable angina, however, chronic oral administration of amlodipine in clinical studies did not cause clinically significant alterations in heart rate or blood pressures in patients diagnosed with angina and normal blood pressure. With long-term, once daily oral administration, antihypertensive effectiveness is maintained for at least 24 hours [FDA label].
**Electrophysiologic effects**
Amlodipine does not change sinoatrial (SA) nodal function or atrioventricular (AV) conduction in animals or humans. In patients who were diagnosed with chronic stable angina, the intravenous administration of 10 mg of amlodipine did not cause clinically significant alterations A-H and H-V conduction and sinus node recovery time after cardiac pacing. Patients administered amlodipine with concomitant beta-blockers produced similar results. In clinical trials in which amlodipine was given in combination with beta-blockers to patients diagnosed with hypertension or angina, no adverse effects on electrocardiographic parameters were noted. In clinical studies comprised of angina patients alone, amlodipine did not change electrocardiographic intervals or produce high degrees of AV block [FDA label].
**Effects on angina**
Amlodipine relieves the symptoms of chest pain associated with angina. In patients diagnosed with angina, daily administration of a single amlodipine dose increases total exercise time, the time to angina onset, and the time to 1 mm ST-segment depression on ECG studies, decreases anginal attack frequency, and decreases the requirement for nitroglycerin tablets [F3757].
|
**Mechanism of action on blood pressure**
Amlodipine is considered a peripheral arterial vasodilator that exerts its action directly on vascular smooth muscle to lead to a reduction in peripheral vascular resistance, causing a decrease in blood pressure. Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the influx of calcium ions into both vascular smooth muscle and cardiac muscle. Experimental studies imply that amlodipine binds to both _dihydropyridine_ and _nondihydropyridine_ binding sites, located on cell membranes. The contraction of cardiac muscle and vascular smooth muscle are dependent on the movement of extracellular calcium ions into these cells by specific ion channels. Amlodipine blocks calcium ion influx across cell membranes with selectivity. A stronger effect of amlodipine is exerted on vascular smooth muscle cells than on cardiac muscle cells [FDA label]. Direct actions of amlodipine on vascular smooth muscle result in reduced blood pressure [F3757].
**Mechanism of action in angina**
The exact mechanism by which amlodipine relieves the symptoms of angina have not been fully elucidated to this date, however, the mechanism of action is likely twofold:
Amlodipine has a dilating effect on peripheral arterioles, reducing the total peripheral resistance (afterload) against which the cardiac muscle functions. Since the heart rate remains stable during amlodipine administration, the reduced work of the heart reduces both myocardial energy use and oxygen requirements [F3757].
Dilatation of the main coronary arteries and coronary arterioles, both in healthy and ischemic areas, is another possible mechanism of amlodipine reduction of blood pressure. The dilatation causes an increase in myocardial oxygen delivery in patients experiencing coronary artery spasm (Prinzmetal's or variant angina) and reduces coronary vasoconstriction caused by smoking [F3757].
|
Amlodipine absorbed slowly and almost completely from the gastrointestinal tract. Peak plasma concentrations are achieved 6-12 hours after oral administration. The estimated bioavailability of amlodipine is 64-90%. Steady-state plasma amlodipine levels are achieved after 7-8 days of consecutive daily dosing. Absorption is not affected by food [FDA label].
|
Amlodipine is heavily (approximately 90%) converted to inactive metabolites via hepatic breakdown with 10% of the parent compound and 60% of the metabolites found excreted in the urine. _Ex vivo_ studies have shown that about 93% of the circulating drug is bound to plasma proteins in hypertensive patients [FDA label]. Characteristics that add to amlodipine's unique pharmacologic profile include nearly complete absorption, late-peak plasma concentrations, high bioavailability, and slow hepatic breakdown [A574].
|
**Acute oral toxicity (LD50)**: 37 mg/kg (mouse) [MSDS].
**Overdose**
An overdose of amlodipine could result in a high degree of peripheral vasodilatation with a possibility of reflex tachycardia. Significant and prolonged hypotension leading to shock and fatal outcomes have been reported [FDA label].
**Carcinogenesis, mutagenesis, impairment of fertility**
Rats and mice treated with amlodipine maleate in the diet on a long-term basis for up to 2 years demonstrated no evidence of a carcinogenic effect of the drug. For the mouse, the highest dose was comparable to the maximum recommended human dose of 10 mg amlodipine per day. For the rat, the highest dose was measured to be about twice the maximum recommended human dose [FDA label].
Mutagenicity studies using amlodipine maleate showed no drug-related gene or chromosomal effects [FDA label].
There was no impact on the fertility of rats given oral amlodipine maleate (males for 64 days and females for 14 days before mating) at doses up to 10 mg amlodipine/kg/day (8 times the maximum recommended human dose) [FDA label].
**Use in pregnancy**
The safety of amlodipine in human pregnancy or lactation has not been proven. Amlodipine is therefore considered a pregnancy category C drug [F3757].
Use amlodipine only if the potential benefit justifies the potential risk [FDA label].
**Use in nursing**
Discontinue when administering amlodipine [FDA label].
|
The terminal elimination half-life of about 30–50 hours [FDA label].
Plasma elimination half-life is 56 hours in patients with impaired hepatic function, titrate slowly when administering this drug to patients with severe hepatic impairment [FDA label].
|
About 98% [A175327], [A175336].
|
Elimination from the plasma occurs in a biphasic with a terminal elimination half-life of about 30–50 hours. Steady-state plasma levels of amlodipine are reached after 7-8 days of consecutive daily dosing [FDA label]. Amlodipine is 10% excreted as unchanged drug in the urine. Amlodipine can be initiated at normal doses in patients diagnosed with renal failure [F3757], [FDA label].
|
21 L/kg [A175327], [A175336].
|
Total body clearance (CL) has been calculated as 7 ± 1.3 ml/min/kg (0.42 ± 0.078 L/ h/kg) in healthy volunteers [A175327], [A175336].
Elderly patients show a reduced clearance of amlodipine with an AUC (area under the curve) increase of about 40–60%, and a lower initial dose may be required [FDA label].
|
Organic compounds
|
Organoheterocyclic compounds
|
Pyridines and derivatives
|
Hydropyridines
|
[
"approved"
] |
[
"C09BB",
"C09B",
"C09",
"C",
"C09BB",
"C09B",
"C09",
"C",
"C10BX",
"C10B",
"C10",
"C",
"C07FB",
"C07F",
"C07",
"C",
"C09DB",
"C09D",
"C09",
"C",
"C09XA",
"C09X",
"C09",
"C",
"C10BX",
"C10B",
"C10",
"C",
"C09BX",
"C09B",
"C09",
"C",
"C09DB",
"C09D",
"C09",
"C",
"C09DX",
"C09D",
"C09",
"C",
"C09BX",
"C09B",
"C09",
"C",
"C10BX",
"C10B",
"C10",
"C",
"C09DB",
"C09D",
"C09",
"C",
"C10BX",
"C10B",
"C10",
"C",
"C09DX",
"C09D",
"C09",
"C",
"C10BX",
"C10B",
"C10",
"C",
"C09DB",
"C09D",
"C09",
"C",
"C09XA",
"C09X",
"C09",
"C",
"C10BX",
"C10B",
"C10",
"C",
"C09BB",
"C09B",
"C09",
"C",
"C07FB",
"C07F",
"C07",
"C",
"C09DB",
"C09D",
"C09",
"C",
"C07FB",
"C07F",
"C07",
"C",
"C09DX",
"C09D",
"C09",
"C",
"C08CA",
"C08C",
"C08",
"C",
"C09BX",
"C09B",
"C09",
"C",
"C09BX",
"C09B",
"C09",
"C",
"C09DB",
"C09D",
"C09",
"C",
"C09DX",
"C09D",
"C09",
"C",
"C08GA",
"C08G",
"C08",
"C",
"C08CA",
"C08C",
"C08",
"C",
"C09DB",
"C09D",
"C09",
"C",
"C10BX",
"C10B",
"C10",
"C",
"C09BB",
"C09B",
"C09",
"C",
"C09DX",
"C09D",
"C09",
"C"
] |
[
"Humans and other mammals"
] |
[
{
"cost": "1.03",
"description": "Amlodipine 10 mg Tablet",
"unit": "tablet"
},
{
"cost": "1.03",
"description": "Apo-Amlodipine 10 mg Tablet",
"unit": "tablet"
},
{
"cost": "1.03",
"description": "Co Amlodipine 10 mg Tablet",
"unit": "tablet"
},
{
"cost": "1.03",
"description": "Gd-Amlodipine 10 mg Tablet",
"unit": "tablet"
},
{
"cost": "1.03",
"description": "Jamp-Amlodipine 10 mg Tablet",
"unit": "tablet"
},
{
"cost": "1.03",
"description": "Mylan-Amlodipine 10 mg Tablet",
"unit": "tablet"
},
{
"cost": "1.03",
"description": "Novo-Amlodipine 10 mg Tablet",
"unit": "tablet"
},
{
"cost": "1.03",
"description": "Phl-Amlodipine 10 mg Tablet",
"unit": "tablet"
},
{
"cost": "1.03",
"description": "Pms-Amlodipine 10 mg Tablet",
"unit": "tablet"
},
{
"cost": "1.03",
"description": "Ran-Amlodipine 10 mg Tablet",
"unit": "tablet"
},
{
"cost": "1.03",
"description": "Ratio-Amlodipine 10 mg Tablet",
"unit": "tablet"
},
{
"cost": "1.03",
"description": "Sandoz Amlodipine 10 mg Tablet",
"unit": "tablet"
},
{
"cost": "1.44",
"description": "Norvasc 5 mg Tablet",
"unit": "tablet"
},
{
"cost": "1.76",
"description": "Amlodipine besylate 2.5 mg tablet",
"unit": "tablet"
},
{
"cost": "1.76",
"description": "Amlodipine besylate 5 mg tablet",
"unit": "tablet"
},
{
"cost": "2.14",
"description": "Norvasc 10 mg Tablet",
"unit": "tablet"
},
{
"cost": "2.36",
"description": "Norvasc 2.5 mg tablet",
"unit": "tablet"
},
{
"cost": "2.36",
"description": "Norvasc 5 mg tablet",
"unit": "tablet"
},
{
"cost": "2.42",
"description": "Amlodipine besylate 10 mg tablet",
"unit": "tablet"
},
{
"cost": "3.16",
"description": "Norvasc 10 mg tablet",
"unit": "tablet"
},
{
"cost": "3.83",
"description": "Lotrel 2.5-10 mg capsule",
"unit": "capsule"
},
{
"cost": "3.91",
"description": "Lotrel 5-10 mg capsule",
"unit": "capsule"
},
{
"cost": "4.13",
"description": "Lotrel 5-20 mg capsule",
"unit": "capsule"
},
{
"cost": "4.37",
"description": "Lotrel 5-40 mg capsule",
"unit": "capsule"
},
{
"cost": "4.8",
"description": "Lotrel 10-20 mg capsule",
"unit": "capsule"
},
{
"cost": "5.21",
"description": "Lotrel 10-40 mg capsule",
"unit": "capsule"
},
{
"cost": "9.99",
"description": "Amlodipine besylate powder",
"unit": "g"
},
{
"cost": "0.35",
"description": "Phl-Amlodipine 2.5 mg Tablet",
"unit": "tablet"
},
{
"cost": "0.35",
"description": "Pms-Amlodipine 2.5 mg Tablet",
"unit": "tablet"
},
{
"cost": "0.7",
"description": "Amlodipine 5 mg Tablet",
"unit": "tablet"
},
{
"cost": "0.7",
"description": "Apo-Amlodipine 5 mg Tablet",
"unit": "tablet"
},
{
"cost": "0.7",
"description": "Co Amlodipine 5 mg Tablet",
"unit": "tablet"
},
{
"cost": "0.7",
"description": "Gd-Amlodipine 5 mg Tablet",
"unit": "tablet"
},
{
"cost": "0.7",
"description": "Jamp-Amlodipine 5 mg Tablet",
"unit": "tablet"
},
{
"cost": "0.7",
"description": "Mylan-Amlodipine 5 mg Tablet",
"unit": "tablet"
},
{
"cost": "0.7",
"description": "Novo-Amlodipine 5 mg Tablet",
"unit": "tablet"
},
{
"cost": "0.7",
"description": "Phl-Amlodipine 5 mg Tablet",
"unit": "tablet"
},
{
"cost": "0.7",
"description": "Pms-Amlodipine 5 mg Tablet",
"unit": "tablet"
},
{
"cost": "0.7",
"description": "Ran-Amlodipine 5 mg Tablet",
"unit": "tablet"
},
{
"cost": "0.7",
"description": "Ratio-Amlodipine 5 mg Tablet",
"unit": "tablet"
},
{
"cost": "0.7",
"description": "Sandoz Amlodipine 5 mg Tablet",
"unit": "tablet"
}
] |
[
{
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"country": "Canada",
"expires": "2014-08-10",
"number": "2170278"
},
{
"approved": "2000-12-19",
"country": "United States",
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"number": "6162802"
},
{
"approved": "1999-10-19",
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"number": "5969156"
},
{
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{
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{
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},
{
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{
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{
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{
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{
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{
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{
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"number": "8618174"
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{
"approved": "2012-05-22",
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{
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{
"approved": "2004-02-24",
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{
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{
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{
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{
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{
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{
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{
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{
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{
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{
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{
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] |
(RS)-3-ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate | 3-Ethyl 5-methylester, (±)-2-[(2-aminoethoxy)methyl]-4-(o-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate | Amlodipine | Amlodipine free base | Amlodipino | Amlodipinum | CACH2 | CACN2 | CACNL1A1 | Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle | CCHL1A1 | Voltage-gated calcium channel subunit alpha Cav1.2 | CACNL2A | CCHL2A | MHS3 | Voltage-gated calcium channel subunit alpha-2/delta-1 | Ca(v)3.3 | KIAA1120 | Voltage-gated calcium channel subunit alpha Cav3.3 | BIII | Brain calcium channel III | CACH5 | CACNL1A5 | Calcium channel, L type, alpha-1 polypeptide isoform 5 | Voltage-gated calcium channel subunit alpha Cav2.2 | CAB1 | CACNLB1 | Calcium channel voltage-dependent subunit beta 1 | Voltage-gated calcium channel subunit alpha-2/delta-3 | 4.2.1.1 | CA-I | CAB | Carbonate dehydratase I | Carbonic anhydrase B | Carbonic anhydrase I | Cyanamide hydratase CA1 | 3.1.4.12 | 3.1.4.3 | Acid sphingomyelinase | ASM | aSMase | BIII | Brain calcium channel III | CACH5 | CACNL1A5 | Calcium channel, L type, alpha-1 polypeptide isoform 5 | Voltage-gated calcium channel subunit alpha Cav2.2 | 1,4-cineole 2-exo-monooxygenase | 1,8-cineole 2-exo-monooxygenase | 1.14.14.1 | Albendazole monooxygenase (sulfoxide-forming) | Albendazole sulfoxidase | Cholesterol 25-hydroxylase | CYP3A3 | CYPIIIA3 | CYPIIIA4 | Cytochrome P450 3A3 | Cytochrome P450 HLp | Cytochrome P450 NF-25 | Cytochrome P450-PCN1 | Nifedipine oxidase | Quinine 3-monooxygenase | 1.14.14.1 | CYPIA1 | Cytochrome P450 form 6 | Cytochrome P450-C | Cytochrome P450-P1 | Hydroperoxy icosatetraenoate dehydratase | 1,4-cineole 2-exo-monooxygenase | 1.14.13.- | CYPIIB6 | Cytochrome P450 IIB1 | 1.14.14.1 | CYPIIIA5 | Cytochrome P450-PCN3 | 1.14.14.1 | CYPIIC8 | Cytochrome P450 form 1 | Cytochrome P450 IIC2 | Cytochrome P450 MP-12 | Cytochrome P450 MP-20 | S-mephenytoin 4-hydroxylase | 1.14.14.- | Cholesterol 25-hydroxylase | CYP2DL1 | CYPIID6 | Cytochrome P450-DB1 | Debrisoquine 4-hydroxylase | (R)-limonene 6-monooxygenase | (S)-limonene 6-monooxygenase | (S)-limonene 7-monooxygenase | 1.14.14.1 | CYPIIC17 | CYPIIC19 | Cytochrome P450-11A | Cytochrome P450-254C | Fenbendazole monooxygenase (4'-hydroxylating) | Mephenytoin 4-hydroxylase | (R)-limonene 6-monooxygenase | (S)-limonene 6-monooxygenase | (S)-limonene 7-monooxygenase | 1.14.14.1 | Cholesterol 25-hydroxylase | CYP2C10 | CYPIIC9 | Cytochrome P-450MP | Cytochrome P450 MP-4 | Cytochrome P450 MP-8 | Cytochrome P450 PB-1 | S-mephenytoin 4-hydroxylase | ATP-binding cassette sub-family B member 1 | MDR1 | Multidrug resistance protein 1 | P-glycoprotein 1 | PGY1 | Phospholipid transporter ABCB1
|
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"Amlodipine",
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"Amlodipine",
"Amlodipine",
"Amlodipine",
"Amlodipine",
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"Amlodipine",
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"Amlodipine and Atorvastatin",
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"Amlodipine and Atorvastatin",
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"Amlodipine and olmesartan Medoxomil",
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"Amlodipine and olmesartan Medoxomil",
"Amlodipine and olmesartan Medoxomil",
"AMLODIPINE and OLMESARTAN medoxomil",
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"Amlodipine and olmesartan medoxomil",
"Amlodipine and olmesartan medoxomil",
"Amlodipine and Olmesartan Medoxomil",
"Amlodipine and Olmesartan Medoxomil",
"Amlodipine and Olmesartan Medoxomil",
"Amlodipine and Olmesartan Medoxomil",
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"AMLODIPINE and VALSARTAN",
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"Amlodipine and Valsartan",
"Amlodipine and Valsartan",
"Amlodipine and Valsartan",
"Amlodipine and Valsartan",
"Amlodipine and Valsartan",
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"Amlodipine and Valsartan",
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"Amlodipine and Valsartan",
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"Amlodipine and Valsartan",
"Amlodipine and Valsartan",
"Amlodipine and Valsartan",
"Amlodipine and Valsartan",
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"Amlodipine Besylate",
"Amlodipine Besylate",
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"Amlodipine besylate",
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"Amlodipine Besylate",
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"Amlodipine Besylate",
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"Amlodipine Besylate",
"Amlodipine Besylate",
"Amlodipine Besylate",
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"AMLODIPINE BESYLATE 10 mg",
"AMLODIPINE BESYLATE 10 mg",
"AMLODIPINE BESYLATE 10 mg",
"AMLODIPINE BESYLATE 10 mg",
"AMLODIPINE BESYLATE 10 mg",
"AMLODIPINE BESYLATE 10 mg",
"AMLODIPINE BESYLATE 10 mg",
"AMLODIPINE BESYLATE 10 mg",
"AMLODIPINE BESYLATE 2.5 mg",
"AMLODIPINE BESYLATE 2.5 mg",
"AMLODIPINE BESYLATE 2.5 mg",
"AMLODIPINE BESYLATE 2.5 mg",
"AMLODIPINE BESYLATE 2.5 mg",
"AMLODIPINE BESYLATE 5 mg",
"AMLODIPINE BESYLATE 5 mg",
"AMLODIPINE BESYLATE 5 mg",
"AMLODIPINE BESYLATE 5 mg",
"AMLODIPINE BESYLATE 5 mg",
"Amlodipine Besylate and Atorvastatin Calcium",
"Amlodipine Besylate and Atorvastatin Calcium",
"Amlodipine Besylate and Atorvastatin Calcium",
"Amlodipine Besylate and Atorvastatin Calcium",
"Amlodipine Besylate and Atorvastatin Calcium",
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"Amlodipine besylate and Atorvastatin calcium",
"Amlodipine besylate and Atorvastatin calcium",
"Amlodipine besylate and Atorvastatin calcium",
"Amlodipine besylate and Atorvastatin calcium",
"Amlodipine Besylate and Benazepril HCL",
"Amlodipine Besylate and Benazepril HCL",
"Amlodipine Besylate and Benazepril HCL",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine besylate and benazepril hydrochloride",
"Amlodipine besylate and benazepril hydrochloride",
"Amlodipine besylate and benazepril hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine besylate and benazepril hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine besylate and benazepril hydrochloride",
"Amlodipine besylate and benazepril hydrochloride",
"Amlodipine besylate and benazepril hydrochloride",
"Amlodipine besylate and benazepril hydrochloride",
"Amlodipine besylate and benazepril hydrochloride",
"Amlodipine besylate and benazepril hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine besylate and Benazepril hydrochloride",
"Amlodipine besylate and Benazepril hydrochloride",
"Amlodipine besylate and Benazepril hydrochloride",
"Amlodipine besylate and Benazepril hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine besylate and benazepril hydrochloride",
"Amlodipine besylate and benazepril hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine besylate and Olmesartan medoxomil",
"Amlodipine besylate and Olmesartan medoxomil",
"Amlodipine besylate and Olmesartan medoxomil",
"Amlodipine besylate and Olmesartan medoxomil",
"Amlodipine Besylate and Olmesartan Medoxomil",
"Amlodipine Besylate and Olmesartan Medoxomil",
"Amlodipine Besylate and Olmesartan Medoxomil",
"Amlodipine Besylate and Olmesartan Medoxomil",
"Amlodipine Besylate and Olmesartan Medoxomil",
"Amlodipine Besylate and Olmesartan Medoxomil",
"Amlodipine Besylate and Olmesartan Medoxomil",
"Amlodipine Besylate and Olmesartan Medoxomil",
"Amlodipine besylate and Olmesartran medoxomil",
"Amlodipine besylate and Olmesartran medoxomil",
"Amlodipine besylate and Olmesartran medoxomil",
"Amlodipine besylate and Olmesartran medoxomil",
"Amlodipine besylate and Olmesartran medoxomil",
"Amlodipine besylate and Olmesartran medoxomil",
"Amlodipine besylate and Olmesartran medoxomil",
"Amlodipine besylate and Olmesartran medoxomil",
"Amlodipine Besylate Tablets, 10mg",
"Amlodipine Besylate Tablets, 5mg",
"Amlodipine besylate/atorvastatin calcium",
"Amlodipine besylate/atorvastatin calcium",
"Amlodipine besylate/atorvastatin calcium",
"Amlodipine besylate/atorvastatin calcium",
"Amlodipine besylate/atorvastatin calcium",
"Amlodipine besylate/atorvastatin calcium",
"Amlodipine besylate/atorvastatin calcium",
"Amlodipine besylate/atorvastatin calcium",
"Amlodipine besylate/atorvastatin calcium",
"Amlodipine besylate/atorvastatin calcium",
"Amlodipine besylate/atorvastatin calcium",
"Amlodipine Tablets",
"Amlodipine Tablets",
"Amlodipine Tablets",
"Amlodipine Tablets",
"Amlodipine Tablets",
"Amlodipine-odan",
"Amlodipine-odan",
"Amlodipine-odan",
"Amlodipine-valsartan Mylan",
"Amlodipine-valsartan Mylan",
"Amlodipine-valsartan Mylan",
"Amlodipine-valsartan Mylan",
"Amlodipine-valsartan Mylan",
"Amlodipine-valsartan Mylan",
"Amlodipine-valsartan Mylan",
"Amlodipine-valsartan Mylan",
"Amlodipine-valsartan Mylan",
"Amlodipine-valsartan Mylan",
"Amlodipine-valsartan Mylan",
"Amlodipine-valsartan Mylan",
"Amlodipine-valsartan Mylan",
"Amlodipine-valsartan Mylan",
"Amlodipine-valsartan Mylan",
"Amlodipine-valsartan Mylan",
"Amlodipine-valsartan Mylan",
"Amlodipine-valsartan Mylan",
"Amlodipine-valsartan Mylan",
"Amlodipine-valsartan Mylan",
"Amlodipine-valsartan Mylan",
"Amlodipine-valsartan Mylan",
"Amlodipine-valsartan Mylan",
"Amlodipine-valsartan Mylan",
"Amlodipine-valsartan Mylan",
"Amlodipine-valsartan Mylan",
"Amlodipine-valsartan Mylan",
"Amlodipine-valsartan Mylan",
"Amlodipine-valsartan Mylan",
"Amlodipine-valsartan Mylan",
"Amlodipine-valsartan Mylan",
"Amlodipine-valsartan Mylan",
"Amlodipine-valsartan Mylan",
"Amlodipine-valsartan Mylan",
"Amlodipine-valsartan Mylan",
"Amlodipine-valsartan Mylan",
"Amlodipine-valsartan Mylan",
"Amlodipine-valsartan Mylan",
"Amlodipine-valsartan Mylan",
"Amlodipine, Valsartan and Hydrochlorothiazide",
"Amlodipine, Valsartan and Hydrochlorothiazide",
"Amlodipine, Valsartan and Hydrochlorothiazide",
"Amlodipine, Valsartan and Hydrochlorothiazide",
"Amlodipine, Valsartan and Hydrochlorothiazide",
"Amlodipine, Valsartan and Hydrochlorothiazide",
"Amlodipine, Valsartan and Hydrochlorothiazide",
"Amlodipine, Valsartan and Hydrochlorothiazide",
"Amlodipine, Valsartan and Hydrochlorothiazide",
"Amlodipine, Valsartan and Hydrochlorothiazide",
"Amlodipine, Valsartan and Hydrochlorothiazide",
"Amlodipine, Valsartan and Hydrochlorothiazide",
"Amlodipine, Valsartan and Hydrochlorothiazide",
"Amlodipine, Valsartan and Hydrochlorothiazide",
"Amlodipine, Valsartan and Hydrochlorothiazide",
"Amlodipine, Valsartan and Hydrochlorothiazide",
"Amlodipine, Valsartan and Hydrochlorothiazide",
"Amlodipine, Valsartan and Hydrochlorothiazide",
"Amlodipine, Valsartan and Hydrochlorothiazide",
"Amlodipine, Valsartan and Hydrochlorothiazide",
"Amlodipine, Valsartan and Hydrochlorothiazide",
"Amlodipine, Valsartan, and Hydrochlorothiazide",
"Amlodipine, Valsartan, and Hydrochlorothiazide",
"Amlodipine, Valsartan, and Hydrochlorothiazide",
"Amlodipine, Valsartan, and Hydrochlorothiazide",
"Amlodipine, Valsartan, and Hydrochlorothiazide",
"Amlodipine, Valsartan, Hydrochlorothiazide",
"Amlodipine, Valsartan, Hydrochlorothiazide",
"Amlodipine, Valsartan, Hydrochlorothiazide",
"Amlodipine, Valsartan, Hydrochlorothiazide",
"Amlodipine, Valsartan, Hydrochlorothiazide",
"Amlodipine, Valsartan, Hydrochlorothiazide",
"Amlodipine, Valsartan, Hydrochlorothiazide",
"Amlodipine, Valsartan, Hydrochlorothiazide",
"Amlodipine, Valsartan, Hydrochlorothiazide",
"Amlodipine, Valsartan, Hydrochlorothiazide",
"Amlodipine, Valsartan, Hydrochlorothiazide",
"Amlodipine, Valsartan, Hydrochlorothiazide",
"Amlodipine, Valsartan, Hydrochlorothiazide",
"Amlodipine, Valsartan, Hydrochlorothiazide",
"Amlodipine, Valsartan, Hydrochlorothiazide",
"Amlodipine, Valsartan, Hydrochlorothiazide",
"Amlodipine, Valsartan, Hydrochlorothiazide",
"Amlodipine, Valsartan, Hydrochlorothiazide",
"Amlodipine, Valsartan, Hydrochlorothiazide",
"Amlodipine, Valsartan, Hydrochlorothiazide",
"Amoldipine Benazepril HCl",
"Amturnide",
"Amturnide",
"Amturnide",
"Amturnide",
"Amturnide",
"Apo-amlodipine",
"Apo-amlodipine",
"Apo-amlodipine",
"Apo-amlodipine-atorvastatin",
"Apo-amlodipine-atorvastatin",
"Apo-amlodipine-atorvastatin",
"Apo-amlodipine-atorvastatin",
"Apo-amlodipine-atorvastatin",
"Apo-amlodipine-atorvastatin",
"Apo-amlodipine-atorvastatin",
"Apo-amlodipine-atorvastatin",
"Apo-perindopril/amlodipine",
"Apo-perindopril/amlodipine",
"Apo-perindopril/amlodipine",
"Apo-telmisartan-amlodipine",
"Apo-telmisartan-amlodipine",
"Apo-telmisartan-amlodipine",
"Apo-telmisartan-amlodipine",
"Auro-amlodipine",
"Auro-amlodipine",
"Ava-amlodipine",
"Ava-amlodipine",
"Azor",
"Azor",
"Azor",
"Azor",
"Azor",
"Azor",
"Azor",
"Azor",
"Azor",
"Azor",
"Bio-amlodipine",
"Bio-amlodipine",
"Bio-amlodipine",
"Caduet",
"Caduet",
"Caduet",
"Caduet",
"Caduet",
"Caduet",
"Caduet",
"Caduet",
"Caduet",
"Caduet",
"Caduet",
"Caduet",
"Caduet",
"Caduet",
"Caduet",
"Caduet",
"Caduet",
"Caduet",
"Caduet",
"Caduet",
"Caduet",
"Caduet",
"Caduet",
"Caduet",
"Caduet",
"Caduet",
"Caduet",
"Caduet",
"Caduet",
"Caduet",
"Caduet",
"Caduet",
"Caduet",
"Caduet",
"Caduet",
"Caduet",
"Caduet",
"Consensi",
"Consensi",
"Consensi",
"Copalia",
"Copalia",
"Copalia",
"Copalia",
"Copalia",
"Copalia",
"Copalia",
"Copalia",
"Copalia",
"Copalia",
"Copalia",
"Copalia",
"Copalia",
"Copalia",
"Copalia",
"Copalia",
"Copalia",
"Copalia",
"Copalia",
"Copalia",
"Copalia",
"Copalia",
"Copalia",
"Copalia",
"Copalia",
"Copalia",
"Copalia",
"Copalia",
"Copalia",
"Copalia",
"Copalia",
"Copalia",
"Copalia",
"Copalia",
"Copalia",
"Copalia",
"Copalia",
"Copalia",
"Copalia",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Dafiro",
"Dafiro",
"Dafiro",
"Dafiro",
"Dafiro",
"Dafiro",
"Dafiro",
"Dafiro",
"Dafiro",
"Dafiro",
"Dafiro",
"Dafiro",
"Dafiro",
"Dafiro",
"Dafiro",
"Dafiro",
"Dafiro",
"Dafiro",
"Dafiro",
"Dafiro",
"Dafiro",
"Dafiro",
"Dafiro",
"Dafiro",
"Dafiro",
"Dafiro",
"Dafiro",
"Dafiro",
"Dafiro",
"Dafiro",
"Dafiro",
"Dafiro",
"Dafiro",
"Dafiro",
"Dafiro",
"Dafiro",
"Dafiro",
"Dafiro",
"Dafiro",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dom-amlodipine",
"Dom-amlodipine",
"Dom-amlodipine",
"Exforge",
"Exforge",
"Exforge",
"Exforge",
"Exforge",
"Exforge",
"Exforge",
"Exforge",
"Exforge",
"Exforge",
"Exforge",
"Exforge",
"Exforge",
"Exforge",
"Exforge",
"Exforge",
"Exforge",
"Exforge",
"Exforge",
"Exforge",
"Exforge",
"Exforge",
"Exforge",
"Exforge",
"Exforge",
"Exforge",
"Exforge",
"Exforge",
"Exforge",
"Exforge",
"Exforge",
"Exforge",
"Exforge",
"Exforge",
"Exforge",
"Exforge",
"Exforge",
"Exforge",
"Exforge",
"Exforge",
"Exforge",
"Exforge",
"Exforge",
"Exforge",
"Exforge",
"Exforge",
"Exforge",
"Exforge",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Gd-amlodipine",
"Gd-amlodipine",
"Gd-amlodipine",
"Hypertenipine",
"Imprida",
"Imprida",
"Imprida",
"Imprida",
"Imprida",
"Imprida",
"Imprida",
"Imprida",
"Imprida",
"Imprida",
"Imprida",
"Imprida",
"Imprida",
"Imprida",
"Imprida",
"Imprida",
"Imprida",
"Imprida",
"Imprida",
"Imprida",
"Imprida",
"Imprida",
"Imprida",
"Imprida",
"Imprida",
"Imprida",
"Imprida",
"Imprida",
"Imprida",
"Imprida",
"Imprida",
"Imprida",
"Imprida",
"Imprida",
"Imprida",
"Imprida",
"Imprida",
"Imprida",
"Imprida",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Ipg-amlodipine",
"Ipg-amlodipine",
"Ipg-amlodipine",
"Jamp-amlodipine",
"Jamp-amlodipine",
"Jamp-amlodipine",
"Jamp-amlodipine",
"Jamp-amlodipine",
"Katerzia",
"Lotrel",
"Lotrel",
"Lotrel",
"Lotrel",
"Lotrel",
"Lotrel",
"Lotrel",
"Lotrel",
"Lotrel",
"Lotrel",
"Lotrel",
"Lotrel",
"Lotrel",
"Lotrel",
"Lotrel",
"Lotrel",
"Lotrel",
"Lotrel",
"Lotrel",
"Lotrel",
"Lotrel",
"M-amlodipine",
"M-amlodipine",
"M-amlodipine",
"Manda-amlodipine Tablets",
"Manda-amlodipine Tablets",
"Manda-amlodipine Tablets",
"Mar-amlodipine",
"Mar-amlodipine",
"Mar-amlodipine",
"Mint-amlodipine",
"Mint-amlodipine",
"Mylan-amlodipine",
"Mylan-amlodipine",
"Mylan-amlodipine/atorvastatin",
"Mylan-amlodipine/atorvastatin",
"Mylan-amlodipine/atorvastatin",
"Mylan-amlodipine/atorvastatin",
"Mylan-amlodipine/atorvastatin",
"Mylan-amlodipine/atorvastatin",
"Mylan-amlodipine/atorvastatin",
"Mylan-amlodipine/atorvastatin",
"Mylan-amlodipine/atorvastatin",
"Mylan-amlodipine/atorvastatin",
"Mylan-amlodipine/atorvastatin",
"Mylan-amlodipine/atorvastatin",
"Mylan-amlodipine/atorvastatin",
"Mylan-amlodipine/atorvastatin",
"Mylan-amlodipine/atorvastatin",
"Mylan-amlodipine/atorvastatin",
"Norliqva",
"Norvasc",
"Norvasc",
"Norvasc",
"Norvasc",
"Norvasc",
"Norvasc",
"Norvasc",
"Norvasc",
"Norvasc",
"Norvasc",
"Norvasc",
"Norvasc",
"Norvasc",
"Norvasc",
"Norvasc",
"Norvasc",
"Norvasc",
"Norvasc",
"Norvasc",
"Norvasc",
"Norvasc",
"Nra-amlodipine",
"Nra-amlodipine",
"Nra-amlodipine",
"Olmesartan Medoxomil / Amlodipine Besylate / Hydrochlorothiazide",
"Olmesartan Medoxomil / Amlodipine Besylate / Hydrochlorothiazide",
"Olmesartan Medoxomil / Amlodipine Besylate / Hydrochlorothiazide",
"Olmesartan Medoxomil / Amlodipine Besylate / Hydrochlorothiazide",
"Olmesartan Medoxomil / Amlodipine Besylate / Hydrochlorothiazide",
"Olmesartan Medoxomil / Amlodipine Besylate / Hydrochlorothiazide",
"Olmesartan Medoxomil / Amlodipine Besylate / Hydrochlorothiazide",
"Olmesartan Medoxomil / Amlodipine Besylate / Hydrochlorothiazide",
"Olmesartan Medoxomil / Amlodipine Besylate / Hydrochlorothiazide",
"Olmesartan Medoxomil / Amlodipine Besylate / Hydrochlorothiazide",
"Olmesartan Medoxomil / Amlodipine Besylate / Hydrochlorothiazide",
"Olmesartan Medoxomil / Amlodipine Besylate / Hydrochlorothiazide",
"Olmesartan Medoxomil / Amlodipine Besylate / Hydrochlorothiazide",
"Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide",
"Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide",
"Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide",
"Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide",
"Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide",
"Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide",
"Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide",
"Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide",
"Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide",
"Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide",
"Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide",
"Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide",
"Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide 20/5/12.5 mg",
"Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide 40/10/12.5 mg",
"Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide 40/10/25 mg",
"Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide 40/5/12.5 mg",
"Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide 40/5/25 mg",
"Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide 40/5/25 mg",
"Pdp-amlodipine",
"Pendo-amlodipine-atorvastatin",
"Pendo-amlodipine-atorvastatin",
"Pendo-amlodipine-atorvastatin",
"Pendo-amlodipine-atorvastatin",
"Pharma-amlodipine",
"Pharma-amlodipine",
"Pharma-amlodipine",
"PHL-amlodipine",
"PHL-amlodipine",
"PHL-amlodipine",
"PMS-amlodipine",
"PMS-amlodipine",
"PMS-amlodipine",
"PMS-amlodipine Mesylate",
"PMS-amlodipine Mesylate",
"PMS-amlodipine-atorvastatin",
"PMS-amlodipine-atorvastatin",
"PMS-amlodipine-atorvastatin",
"PMS-amlodipine-atorvastatin",
"PMS-perindopril-amlodipine",
"PMS-perindopril-amlodipine",
"PMS-perindopril-amlodipine",
"Prestalia",
"Prestalia",
"Prestalia",
"Prestalia",
"Prestalia",
"Prestalia",
"Prz-amlodipine",
"Prz-amlodipine",
"Prz-amlodipine",
"Q-amlodipine",
"Q-amlodipine",
"Q-gen Amlodipine",
"Q-gen Amlodipine",
"Ran-amlodipine",
"Ratio-amlodipine Tablets 10mg",
"Ratio-amlodipine Tablets 5mg",
"Riva-amlodipine",
"Riva-amlodipine",
"Riva-amlodipine",
"Sandoz Amlodipine",
"Sandoz Amlodipine",
"Sandoz Amlodipine",
"Septa-amlodipine",
"Septa-amlodipine",
"Septa-amlodipine",
"Taro-amlodipine",
"Taro-amlodipine",
"Tekamlo",
"Tekamlo",
"Tekamlo",
"Tekamlo",
"Telmisartan and Amlodipine",
"Telmisartan and Amlodipine",
"Telmisartan and Amlodipine",
"Telmisartan and Amlodipine",
"Telmisartan and Amlodipine",
"Telmisartan and Amlodipine",
"Telmisartan and Amlodipine",
"Telmisartan and Amlodipine",
"Telmisartan and Amlodipine",
"Telmisartan and Amlodipine",
"Telmisartan and Amlodipine",
"Telmisartan and Amlodipine",
"Telmisartan and Amlodipine",
"Telmisartan and Amlodipine",
"Telmisartan and Amlodipine",
"Telmisartan and Amlodipine",
"Telmisartan and Amlodipine",
"Telmisartan and Amlodipine",
"Telmisartan and Amlodipine",
"Telmisartan and Amlodipine",
"Teva-amlodipine",
"Teva-amlodipine",
"Teva-amlodipine",
"Teva-amlodipine",
"Teva-amlodipine",
"Tribenzor",
"Tribenzor",
"Tribenzor",
"Tribenzor",
"Tribenzor",
"Tribenzor",
"Tribenzor",
"Tribenzor",
"Tribenzor",
"Tribenzor",
"Twynsta",
"Twynsta",
"Twynsta",
"Twynsta",
"Twynsta",
"Twynsta",
"Twynsta",
"Twynsta",
"Twynsta",
"Twynsta",
"Twynsta",
"Twynsta",
"Twynsta",
"Twynsta",
"Twynsta",
"Twynsta",
"Twynsta",
"Twynsta",
"Twynsta",
"Twynsta",
"Twynsta",
"Twynsta",
"Twynsta",
"Twynsta",
"Twynsta",
"Twynsta",
"Twynsta",
"Twynsta",
"Twynsta",
"Twynsta",
"Twynsta",
"Twynsta",
"Twynsta",
"Twynsta",
"Twynsta",
"Twynsta",
"Van-amlodipine",
"Van-amlodipine",
"Viacoram",
"Viacoram",
"Viacoram",
"Zym-amlodipine",
"Zym-amlodipine"
] |
[
"Aforbes",
"Agen",
"Aken",
"Amcard",
"Amdepin",
"Amdipin",
"Amilostad",
"Amlocard",
"Amlod",
"Amlodine",
"Amlodipin",
"Amlodipin-Mepha 5/10",
"Amlodipine 5",
"Amlodis",
"Amlong",
"Amlopin",
"Amlopine",
"Amlostin",
"Amlosun",
"Amlovas",
"Amlovasc",
"Amlozek",
"Amvaz",
"Asomex",
"Atecard-AM",
"Camlodin",
"Cardilopina",
"Coroval",
"Dailyvasc",
"Istin",
"Lama",
"Lodip",
"Lodopin",
"Lopin",
"Nelod",
"Nopidin",
"Nordip",
"Perivasc",
"Pharex Amlodipine",
"Tenox"
] |
[
"Caduet",
"Caduet",
"Caduet",
"Caduet",
"Caduet",
"Caduet",
"Caduet",
"Caduet",
"Caduet",
"Caduet",
"Hypertenipine",
"Amlobenz",
"Exforge HCT",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlobenz",
"Azor",
"Azor",
"Amlodipine besylate and benazepril hydrochloride",
"Amlodipine besylate and benazepril hydrochloride",
"Amlodipine besylate and benazepril hydrochloride",
"Amlodipine Besylate and Atorvastatin Calcium",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Exforge",
"Exforge",
"Exforge",
"Exforge",
"Lotrel",
"Lotrel",
"Lotrel",
"Lotrel",
"Lotrel",
"Lotrel",
"Lotrel",
"Lotrel",
"Lotrel",
"Lotrel",
"Lotrel",
"Lotrel",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine besylate and benazepril hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"AMLODIPINE and VALSARTAN",
"Amlodipine and Valsartan",
"Amlodipine and Valsartan",
"Amlodipine and Valsartan",
"Amlodipine Besylate and Benazepril HCL",
"Amlodipine Besylate and Benazepril HCL",
"Amlodipine Besylate and Benazepril HCL",
"Exforge HCT",
"Amlodipine besylate and benazepril hydrochloride",
"Amlodipine besylate and benazepril hydrochloride",
"Amlodipine besylate and benazepril hydrochloride",
"Amlodipine besylate and benazepril hydrochloride",
"Amlodipine besylate and benazepril hydrochloride",
"Amlodipine besylate and benazepril hydrochloride",
"Exforge",
"Amturnide",
"Amturnide",
"Amturnide",
"Amturnide",
"Amturnide",
"Tekamlo",
"Tekamlo",
"Tekamlo",
"Tekamlo",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine and Valsartan",
"Amlodipine and Valsartan",
"Amlodipine and Valsartan",
"Amlodipine and Valsartan",
"Amlodipine, Valsartan and Hydrochlorothiazide",
"Amlodipine, Valsartan and Hydrochlorothiazide",
"Amlodipine, Valsartan and Hydrochlorothiazide",
"Amlodipine, Valsartan and Hydrochlorothiazide",
"Amlodipine, Valsartan and Hydrochlorothiazide",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine besylate/atorvastatin calcium",
"Amlodipine besylate/atorvastatin calcium",
"Amlodipine besylate/atorvastatin calcium",
"Amlodipine besylate/atorvastatin calcium",
"Amlodipine besylate/atorvastatin calcium",
"Amlodipine besylate/atorvastatin calcium",
"Amlodipine besylate/atorvastatin calcium",
"Amlodipine besylate/atorvastatin calcium",
"Amlodipine besylate/atorvastatin calcium",
"Amlodipine besylate/atorvastatin calcium",
"Amlodipine besylate/atorvastatin calcium",
"Amlodipine and Valsartan",
"Amlodipine and Valsartan",
"Amlodipine and Valsartan",
"Amlodipine and Valsartan",
"Amlodipine and olmesartan Medoxomil",
"Amlodipine and olmesartan Medoxomil",
"Amlodipine and olmesartan Medoxomil",
"Amlodipine and olmesartan Medoxomil",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine and Valsartan",
"Amlodipine and Valsartan",
"Amlodipine and Valsartan",
"Amlodipine and Valsartan",
"AMLODIPINE and OLMESARTAN medoxomil",
"AMLODIPINE and OLMESARTAN medoxomil",
"AMLODIPINE and OLMESARTAN medoxomil",
"AMLODIPINE and OLMESARTAN medoxomil",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine and olmesartan medoxomil",
"Amlodipine and olmesartan medoxomil",
"Amlodipine and olmesartan medoxomil",
"Amlodipine and olmesartan medoxomil",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine and Olmesartan Medoxomil",
"Amlodipine and Olmesartan Medoxomil",
"Amlodipine and Olmesartan Medoxomil",
"Amlodipine and Olmesartan Medoxomil",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Telmisartan and Amlodipine",
"Telmisartan and Amlodipine",
"Telmisartan and Amlodipine",
"Telmisartan and Amlodipine",
"Amlodipine Besylate and Atorvastatin Calcium",
"Amlodipine Besylate and Atorvastatin Calcium",
"Amlodipine Besylate and Atorvastatin Calcium",
"Amlodipine Besylate and Atorvastatin Calcium",
"Amlodipine Besylate and Atorvastatin Calcium",
"Amlodipine Besylate and Atorvastatin Calcium",
"Amlodipine Besylate and Atorvastatin Calcium",
"Amlodipine Besylate and Atorvastatin Calcium",
"Amlodipine Besylate and Atorvastatin Calcium",
"Amlodipine Besylate and Atorvastatin Calcium",
"Amlodipine Besylate and Atorvastatin Calcium",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine and Valsartan",
"Amlodipine and Valsartan",
"Amlodipine and Valsartan",
"Amlodipine and Valsartan",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine and Valsartan",
"Amlodipine and Valsartan",
"Amlodipine and Valsartan",
"Amlodipine and Valsartan",
"Amlodipine, Valsartan, Hydrochlorothiazide",
"Amlodipine, Valsartan, Hydrochlorothiazide",
"Amlodipine, Valsartan, Hydrochlorothiazide",
"Amlodipine, Valsartan, Hydrochlorothiazide",
"Amlodipine, Valsartan, Hydrochlorothiazide",
"Amlodipine besylate and Benazepril hydrochloride",
"Amlodipine besylate and Benazepril hydrochloride",
"Amlodipine besylate and Benazepril hydrochloride",
"Amlodipine besylate and Benazepril hydrochloride",
"Amlodipine and Olmesartan Medoxomil",
"Amlodipine and valsartan",
"Amlodipine and Valsartan",
"Amlodipine and Valsartan",
"Amlodipine and Valsartan",
"Amlodipine and Olmesartan Medoxomil",
"Amlodipine and Olmesartan Medoxomil",
"Amlodipine and Olmesartan Medoxomil",
"Amlodipine and Olmesartan Medoxomil",
"Amlodipine and Olmesartan Medoxomil",
"Amlodipine and Olmesartan Medoxomil",
"Amlodipine and Olmesartan Medoxomil",
"Amlodipine and Olmesartan Medoxomil",
"Amlodipine and Olmesartan Medoxomil",
"Amlodipine and Olmesartan Medoxomil",
"Telmisartan and Amlodipine",
"Telmisartan and Amlodipine",
"Telmisartan and Amlodipine",
"Telmisartan and Amlodipine",
"Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide",
"Amlodipine, Valsartan, and Hydrochlorothiazide",
"Amlodipine, Valsartan, and Hydrochlorothiazide",
"Amlodipine, Valsartan, and Hydrochlorothiazide",
"Amlodipine, Valsartan, and Hydrochlorothiazide",
"Amlodipine, Valsartan, and Hydrochlorothiazide",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine and Valsartan",
"Amlodipine and Valsartan",
"Amlodipine and Valsartan",
"Amlodipine and Valsartan",
"Amlodipine and Valsartan",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Amoldipine Benazepril HCl",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Telmisartan and Amlodipine",
"Telmisartan and Amlodipine",
"Telmisartan and Amlodipine",
"Telmisartan and Amlodipine",
"Amlodipine and atorvastatin",
"Amlodipine and atorvastatin",
"Amlodipine and atorvastatin",
"Amlodipine and atorvastatin",
"Amlodipine and atorvastatin",
"Amlodipine and atorvastatin",
"Amlodipine and atorvastatin",
"Amlodipine and atorvastatin",
"Amlodipine and atorvastatin",
"Amlodipine and atorvastatin",
"Amlodipine and atorvastatin",
"Amlodipine and atorvastatin",
"Amlodipine and atorvastatin",
"Amlodipine and atorvastatin",
"Amlodipine and atorvastatin",
"Amlodipine and atorvastatin",
"Amlodipine and atorvastatin",
"Amlodipine and atorvastatin",
"Amlodipine and atorvastatin",
"Amlodipine and atorvastatin",
"Amlodipine and atorvastatin",
"Amlodipine and atorvastatin",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine and atorvastatin",
"Amlodipine and atorvastatin",
"Amlodipine and atorvastatin",
"Amlodipine and atorvastatin",
"Amlodipine and atorvastatin",
"Amlodipine and atorvastatin",
"Amlodipine and atorvastatin",
"Amlodipine and atorvastatin",
"Amlodipine and atorvastatin",
"Amlodipine and atorvastatin",
"Amlodipine and atorvastatin",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Olmesartan Medoxomil / Amlodipine Besylate / Hydrochlorothiazide",
"Olmesartan Medoxomil / Amlodipine Besylate / Hydrochlorothiazide",
"Olmesartan Medoxomil / Amlodipine Besylate / Hydrochlorothiazide",
"Olmesartan Medoxomil / Amlodipine Besylate / Hydrochlorothiazide",
"Olmesartan Medoxomil / Amlodipine Besylate / Hydrochlorothiazide",
"Amlodipine, Valsartan and Hydrochlorothiazide",
"Amlodipine, Valsartan and Hydrochlorothiazide",
"Amlodipine, Valsartan and Hydrochlorothiazide",
"Amlodipine, Valsartan and Hydrochlorothiazide",
"Amlodipine, Valsartan and Hydrochlorothiazide",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine besylate and Olmesartran medoxomil",
"Amlodipine besylate and Olmesartran medoxomil",
"Amlodipine besylate and Olmesartran medoxomil",
"Amlodipine besylate and Olmesartran medoxomil",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine and Valsartan",
"Amlodipine and Valsartan",
"Amlodipine and Valsartan",
"Amlodipine and Valsartan",
"Amlodipine and Olmesartan Medoxomil",
"Amlodipine and Olmesartan Medoxomil",
"Amlodipine and Olmesartan Medoxomil",
"Amlodipine and Olmesartan Medoxomil",
"Amlodipine besylate and Olmesartran medoxomil",
"Amlodipine besylate and Olmesartran medoxomil",
"Amlodipine besylate and Olmesartran medoxomil",
"Amlodipine besylate and Olmesartran medoxomil",
"Amlodipine, Valsartan and Hydrochlorothiazide",
"Amlodipine, Valsartan and Hydrochlorothiazide",
"Amlodipine, Valsartan and Hydrochlorothiazide",
"Amlodipine, Valsartan and Hydrochlorothiazide",
"Amlodipine, Valsartan and Hydrochlorothiazide",
"Telmisartan and Amlodipine",
"Telmisartan and Amlodipine",
"Telmisartan and Amlodipine",
"Telmisartan and Amlodipine",
"Amlodipine and Olmesartan Medoxomil",
"Lotrel",
"Lotrel",
"Amlodipine and Olmesartan Medoxomil",
"Amlodipine and Olmesartan Medoxomil",
"Amlodipine and Olmesartan Medoxomil",
"Amlodipine and Olmesartan Medoxomil",
"Telmisartan and Amlodipine",
"Telmisartan and Amlodipine",
"Telmisartan and Amlodipine",
"Telmisartan and Amlodipine",
"Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide 20/5/12.5 mg",
"Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide 40/5/12.5 mg",
"Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide 40/5/25 mg",
"Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide 40/10/12.5 mg",
"Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide 40/10/25 mg",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine and Valsartan",
"Amlodipine and Valsartan",
"Amlodipine and Valsartan",
"Amlodipine and Valsartan",
"Amlodipine, Valsartan and Hydrochlorothiazide",
"Amlodipine, Valsartan and Hydrochlorothiazide",
"Amlodipine, Valsartan and Hydrochlorothiazide",
"Amlodipine, Valsartan and Hydrochlorothiazide",
"Amlodipine, Valsartan and Hydrochlorothiazide",
"Amlodipine and Valsartan",
"Amlodipine and Valsartan",
"Amlodipine and Valsartan",
"Amlodipine and Valsartan",
"Prestalia",
"Prestalia",
"Prestalia",
"Prestalia",
"Prestalia",
"Prestalia",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine besylate and Olmesartan medoxomil",
"Amlodipine besylate and Olmesartan medoxomil",
"Amlodipine besylate and Olmesartan medoxomil",
"Amlodipine besylate and Olmesartan medoxomil",
"Amlodipine, Valsartan, Hydrochlorothiazide",
"Amlodipine, Valsartan, Hydrochlorothiazide",
"Amlodipine, Valsartan, Hydrochlorothiazide",
"Amlodipine, Valsartan, Hydrochlorothiazide",
"Amlodipine, Valsartan, Hydrochlorothiazide",
"Amlodipine and valsartan",
"Amlodipine and valsartan",
"Amlodipine and valsartan",
"Amlodipine and valsartan",
"Amlodipine and Valsartan",
"Amlodipine and Valsartan",
"Amlodipine and Valsartan",
"Amlodipine and Valsartan",
"Amlodipine and olmesartan medoxomil",
"Amlodipine and olmesartan medoxomil",
"Amlodipine and olmesartan medoxomil",
"Amlodipine and olmesartan medoxomil",
"Amlodipine and olmesartan medoxomil",
"Amlodipine and olmesartan medoxomil",
"Amlodipine and olmesartan medoxomil",
"Amlodipine and olmesartan medoxomil",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide",
"Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide",
"Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide",
"Azor",
"Azor",
"Azor",
"Azor",
"Amlodipine and Olmesartan Medoxomil",
"Amlodipine and Olmesartan Medoxomil",
"Amlodipine and Olmesartan Medoxomil",
"Amlodipine and Olmesartan Medoxomil",
"Amlodipine and Olmesartan Medoxomil",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine besylate and Atorvastatin calcium",
"Amlodipine besylate and Atorvastatin calcium",
"Amlodipine besylate and Atorvastatin calcium",
"Amlodipine besylate and Atorvastatin calcium",
"Amlodipine besylate and Atorvastatin calcium",
"Amlodipine besylate and Atorvastatin calcium",
"Amlodipine besylate and Atorvastatin calcium",
"Amlodipine besylate and Atorvastatin calcium",
"Amlodipine besylate and Atorvastatin calcium",
"Amlodipine besylate and Atorvastatin calcium",
"Amlodipine besylate and Atorvastatin calcium",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Twynsta",
"Twynsta",
"Twynsta",
"Twynsta",
"Amlodipine and Valsartan",
"Amlodipine and Valsartan",
"Amlodipine and Valsartan",
"Amlodipine and Valsartan",
"Caduet",
"Caduet",
"Caduet",
"Caduet",
"Caduet",
"Caduet",
"Caduet",
"Caduet",
"Caduet",
"Caduet",
"Caduet",
"Amlodipine besylate and Atorvastatin calcium",
"Amlodipine besylate and Atorvastatin calcium",
"Amlodipine besylate and Atorvastatin calcium",
"Amlodipine besylate and Atorvastatin calcium",
"Amlodipine besylate and Atorvastatin calcium",
"Amlodipine besylate and Atorvastatin calcium",
"Amlodipine besylate and Atorvastatin calcium",
"Amlodipine besylate and Atorvastatin calcium",
"Amlodipine besylate and Atorvastatin calcium",
"Amlodipine besylate and Atorvastatin calcium",
"Amlodipine besylate and Atorvastatin calcium",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Lotrel",
"Lotrel",
"Lotrel",
"Lotrel",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge",
"Exforge",
"Exforge",
"Exforge",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine, Valsartan and Hydrochlorothiazide",
"Amlodipine and Olmesartan Medoxomil",
"Amlodipine and Olmesartan Medoxomil",
"Amlodipine and Olmesartan Medoxomil",
"Amlodipine and Olmesartan Medoxomil",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine and Valsartan",
"Amlodipine and Valsartan",
"Amlodipine and Valsartan",
"Amlodipine and Valsartan",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine and Olmesartan Medoxomil",
"Amlodipine and Olmesartan Medoxomil",
"Amlodipine and Olmesartan Medoxomil",
"Amlodipine and Olmesartan Medoxomil",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine and Valsartan",
"Amlodipine and Valsartan",
"Amlodipine and Valsartan",
"Amlodipine and Valsartan",
"Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide 40/5/25 mg",
"Tribenzor",
"Tribenzor",
"Tribenzor",
"Tribenzor",
"Tribenzor",
"Consensi",
"Consensi",
"Consensi",
"Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide",
"Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide",
"Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide",
"Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide",
"Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine besylate and benazepril hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine besylate and benazepril hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Lotrel",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Lotrel",
"Lotrel",
"Amlodipine and Benazepril Hydrochloride",
"Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide",
"Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide",
"Amlodipine and Atorvastatin",
"Amlodipine and Atorvastatin",
"Amlodipine and Atorvastatin",
"Amlodipine and Atorvastatin",
"Amlodipine and Atorvastatin",
"Amlodipine and Atorvastatin",
"Amlodipine and Atorvastatin",
"Amlodipine and Atorvastatin",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Olmesartan Medoxomil / Amlodipine Besylate / Hydrochlorothiazide",
"Olmesartan Medoxomil / Amlodipine Besylate / Hydrochlorothiazide",
"Olmesartan Medoxomil / Amlodipine Besylate / Hydrochlorothiazide",
"Olmesartan Medoxomil / Amlodipine Besylate / Hydrochlorothiazide",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Caduet",
"Caduet",
"Caduet",
"Caduet",
"Caduet",
"Caduet",
"Caduet",
"Caduet",
"Mylan-amlodipine/atorvastatin",
"Mylan-amlodipine/atorvastatin",
"Mylan-amlodipine/atorvastatin",
"Mylan-amlodipine/atorvastatin",
"Mylan-amlodipine/atorvastatin",
"Mylan-amlodipine/atorvastatin",
"Mylan-amlodipine/atorvastatin",
"Mylan-amlodipine/atorvastatin",
"Twynsta",
"Twynsta",
"Twynsta",
"Twynsta",
"Apo-amlodipine-atorvastatin",
"Apo-amlodipine-atorvastatin",
"Apo-amlodipine-atorvastatin",
"Apo-amlodipine-atorvastatin",
"Apo-amlodipine-atorvastatin",
"Apo-amlodipine-atorvastatin",
"Apo-amlodipine-atorvastatin",
"Apo-amlodipine-atorvastatin",
"Pendo-amlodipine-atorvastatin",
"Pendo-amlodipine-atorvastatin",
"Pendo-amlodipine-atorvastatin",
"Pendo-amlodipine-atorvastatin",
"Viacoram",
"Viacoram",
"Viacoram",
"Mylan-amlodipine/atorvastatin",
"Mylan-amlodipine/atorvastatin",
"Mylan-amlodipine/atorvastatin",
"Mylan-amlodipine/atorvastatin",
"Mylan-amlodipine/atorvastatin",
"Mylan-amlodipine/atorvastatin",
"Mylan-amlodipine/atorvastatin",
"Mylan-amlodipine/atorvastatin",
"PMS-amlodipine-atorvastatin",
"PMS-amlodipine-atorvastatin",
"PMS-amlodipine-atorvastatin",
"PMS-amlodipine-atorvastatin",
"Apo-telmisartan-amlodipine",
"Apo-telmisartan-amlodipine",
"Apo-telmisartan-amlodipine",
"Apo-telmisartan-amlodipine",
"Apo-perindopril/amlodipine",
"Apo-perindopril/amlodipine",
"Apo-perindopril/amlodipine",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Caduet",
"Caduet",
"Caduet",
"Caduet",
"Caduet",
"Caduet",
"Caduet",
"Caduet",
"Amlodipine and Atorvastatin",
"Amlodipine and Atorvastatin",
"Amlodipine and Atorvastatin",
"Amlodipine and Atorvastatin",
"Amlodipine and Atorvastatin",
"Amlodipine and Atorvastatin",
"Amlodipine and Atorvastatin",
"Amlodipine and Atorvastatin",
"Amlodipine and Atorvastatin",
"Amlodipine and Atorvastatin",
"Amlodipine and Atorvastatin",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Tribenzor",
"Tribenzor",
"Tribenzor",
"Tribenzor",
"Tribenzor",
"Azor",
"Azor",
"Azor",
"Azor",
"Amlodipine, Valsartan, Hydrochlorothiazide",
"Amlodipine, Valsartan, Hydrochlorothiazide",
"Amlodipine, Valsartan, Hydrochlorothiazide",
"Amlodipine, Valsartan, Hydrochlorothiazide",
"Amlodipine, Valsartan, Hydrochlorothiazide",
"Amlodipine and Valsartan",
"Amlodipine and Valsartan",
"Amlodipine and Valsartan",
"Amlodipine and Valsartan",
"Amlodipine Besylate and Olmesartan Medoxomil",
"Amlodipine Besylate and Olmesartan Medoxomil",
"Amlodipine Besylate and Olmesartan Medoxomil",
"Amlodipine Besylate and Olmesartan Medoxomil",
"Amlodipine, Valsartan, Hydrochlorothiazide",
"Amlodipine, Valsartan, Hydrochlorothiazide",
"Amlodipine, Valsartan, Hydrochlorothiazide",
"Amlodipine, Valsartan, Hydrochlorothiazide",
"Amlodipine, Valsartan, Hydrochlorothiazide",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine and Valsartan",
"Amlodipine and Valsartan",
"Amlodipine and Valsartan",
"Amlodipine and Valsartan",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine and Valsartan",
"Amlodipine and Valsartan",
"Amlodipine and Valsartan",
"Amlodipine and Valsartan",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine and Atorvastatin",
"Amlodipine and Atorvastatin",
"Amlodipine and Atorvastatin",
"Amlodipine and Atorvastatin",
"Amlodipine and Atorvastatin",
"Amlodipine and Atorvastatin",
"Olmesartan Medoxomil / Amlodipine Besylate / Hydrochlorothiazide",
"Olmesartan Medoxomil / Amlodipine Besylate / Hydrochlorothiazide",
"PMS-perindopril-amlodipine",
"PMS-perindopril-amlodipine",
"PMS-perindopril-amlodipine",
"Olmesartan Medoxomil / Amlodipine Besylate / Hydrochlorothiazide",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine Besylate and Olmesartan Medoxomil",
"Amlodipine and Olmesartan Medoxomil",
"Amlodipine and Olmesartan Medoxomil",
"Amlodipine and Olmesartan Medoxomil",
"Amlodipine and Olmesartan Medoxomil",
"Amlodipine Besylate and Olmesartan Medoxomil",
"Amlodipine Besylate and Olmesartan Medoxomil",
"Amlodipine Besylate and Olmesartan Medoxomil",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine and Olmesartan Medoxomil",
"Amlodipine and Olmesartan Medoxomil",
"Amlodipine and Olmesartan Medoxomil",
"Amlodipine and Olmesartan Medoxomil",
"Amlodipine and Benazepril Hydrochloride",
"Amlodipine and Olmesartan Medoxomil",
"Olmesartan Medoxomil / Amlodipine Besylate / Hydrochlorothiazide",
"Amlodipine Besylate and Benazepril Hydrochloride",
"Amlodipine and Benazepril Hydrochloride",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Imprida HCT",
"Dafiro",
"Dafiro",
"Dafiro",
"Dafiro",
"Dafiro",
"Dafiro",
"Dafiro",
"Dafiro",
"Dafiro",
"Dafiro",
"Dafiro",
"Dafiro",
"Dafiro",
"Dafiro",
"Dafiro",
"Dafiro",
"Dafiro",
"Dafiro",
"Dafiro",
"Dafiro",
"Dafiro",
"Dafiro",
"Dafiro",
"Dafiro",
"Dafiro",
"Dafiro",
"Dafiro",
"Dafiro",
"Dafiro",
"Dafiro",
"Dafiro",
"Dafiro",
"Dafiro",
"Dafiro",
"Dafiro",
"Dafiro",
"Dafiro",
"Dafiro",
"Dafiro",
"Twynsta",
"Twynsta",
"Twynsta",
"Twynsta",
"Twynsta",
"Twynsta",
"Twynsta",
"Twynsta",
"Twynsta",
"Twynsta",
"Twynsta",
"Twynsta",
"Twynsta",
"Twynsta",
"Twynsta",
"Twynsta",
"Twynsta",
"Twynsta",
"Twynsta",
"Twynsta",
"Twynsta",
"Twynsta",
"Twynsta",
"Twynsta",
"Twynsta",
"Twynsta",
"Twynsta",
"Twynsta",
"Amlodipine-valsartan Mylan",
"Amlodipine-valsartan Mylan",
"Amlodipine-valsartan Mylan",
"Amlodipine-valsartan Mylan",
"Amlodipine-valsartan Mylan",
"Amlodipine-valsartan Mylan",
"Amlodipine-valsartan Mylan",
"Amlodipine-valsartan Mylan",
"Amlodipine-valsartan Mylan",
"Amlodipine-valsartan Mylan",
"Amlodipine-valsartan Mylan",
"Amlodipine-valsartan Mylan",
"Amlodipine-valsartan Mylan",
"Amlodipine-valsartan Mylan",
"Amlodipine-valsartan Mylan",
"Amlodipine-valsartan Mylan",
"Amlodipine-valsartan Mylan",
"Amlodipine-valsartan Mylan",
"Amlodipine-valsartan Mylan",
"Amlodipine-valsartan Mylan",
"Amlodipine-valsartan Mylan",
"Amlodipine-valsartan Mylan",
"Amlodipine-valsartan Mylan",
"Amlodipine-valsartan Mylan",
"Amlodipine-valsartan Mylan",
"Amlodipine-valsartan Mylan",
"Amlodipine-valsartan Mylan",
"Amlodipine-valsartan Mylan",
"Amlodipine-valsartan Mylan",
"Amlodipine-valsartan Mylan",
"Amlodipine-valsartan Mylan",
"Amlodipine-valsartan Mylan",
"Amlodipine-valsartan Mylan",
"Amlodipine-valsartan Mylan",
"Amlodipine-valsartan Mylan",
"Amlodipine-valsartan Mylan",
"Amlodipine-valsartan Mylan",
"Amlodipine-valsartan Mylan",
"Amlodipine-valsartan Mylan",
"Amlodipine and Valsartan",
"Amlodipine and Valsartan",
"Amlodipine and Valsartan",
"Amlodipine and Valsartan",
"Copalia",
"Copalia",
"Copalia",
"Copalia",
"Copalia",
"Copalia",
"Copalia",
"Copalia",
"Copalia",
"Copalia",
"Copalia",
"Copalia",
"Copalia",
"Copalia",
"Copalia",
"Copalia",
"Copalia",
"Copalia",
"Copalia",
"Copalia",
"Copalia",
"Copalia",
"Copalia",
"Copalia",
"Copalia",
"Copalia",
"Copalia",
"Copalia",
"Copalia",
"Copalia",
"Copalia",
"Copalia",
"Copalia",
"Copalia",
"Copalia",
"Copalia",
"Copalia",
"Copalia",
"Copalia",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Copalia HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Dafiro HCT",
"Imprida",
"Imprida",
"Imprida",
"Imprida",
"Imprida",
"Imprida",
"Imprida",
"Imprida",
"Imprida",
"Imprida",
"Imprida",
"Imprida",
"Imprida",
"Imprida",
"Imprida",
"Imprida",
"Imprida",
"Imprida",
"Imprida",
"Imprida",
"Imprida",
"Imprida",
"Imprida",
"Imprida",
"Imprida",
"Imprida",
"Imprida",
"Imprida",
"Imprida",
"Imprida",
"Imprida",
"Imprida",
"Imprida",
"Imprida",
"Imprida",
"Imprida",
"Imprida",
"Imprida",
"Imprida",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge HCT",
"Exforge",
"Exforge",
"Exforge",
"Exforge",
"Exforge",
"Exforge",
"Exforge",
"Exforge",
"Exforge",
"Exforge",
"Exforge",
"Exforge",
"Exforge",
"Exforge",
"Exforge",
"Exforge",
"Exforge",
"Exforge",
"Exforge",
"Exforge",
"Exforge",
"Exforge",
"Exforge",
"Exforge",
"Exforge",
"Exforge",
"Exforge",
"Exforge",
"Exforge",
"Exforge",
"Exforge",
"Exforge",
"Exforge",
"Exforge",
"Exforge",
"Exforge",
"Exforge",
"Exforge",
"Exforge"
] |
[
"Q13936",
"P54289",
"Q9P0X4",
"Q00975",
"Q02641",
"Q8IZS8",
"P00915",
"P17405",
"A0A024R8I1",
"Q00975"
] |
[
"P08684",
"P04798",
"P20813",
"P20815",
"P10632",
"P10635",
"P33261",
"P11712"
] |
[] |
[
"P08183"
] |
DB00382
|
Tacrine
|
A centerally active cholinesterase inhibitor that has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. Tacrine has been discontinued for the United States market.
|
solid
|
For the palliative treatment of mild to moderate dementia of the Alzheimer's type.
|
Tacrine is a parasympathomimetic- a reversible cholinesterase inhibitor that is indicated for the treatment of mild to moderate dementia of the Alzheimer's type. An early pathophysiological feature of Alzheimer's disease that is associated with memory loss and cognitive deficits is a deficiency of acetylcholine as a result of selective loss of cholinergic neurons in the cerebral cortex, nucleus basalis, and hippocampus. Tacrine is postulated to exert its therapeutic effect by enhancing cholinergic function. This is accomplished by increasing the concentration of acetylcholine at cholinergic synapses through reversible inhibition of its hydrolysis by acetylcholinesterase. If this proposed mechanism of action is correct, tacrine's effect may lessen as the disease progresses and fewer cholinergic neurons remain functionally intact. There is no evidence that tacrine alters the course of the underlying dementing process.
|
The mechanism of tacrine is not fully known, but it is suggested that the drug is an anticholinesterase agent which reversibly binds with and inactivates cholinesterases. This inhibits the hydrolysis of acetylcholine released from functioning cholinergic neurons, thus leading to an accumulation of acetylcholine at cholinergic synapses. The result is a prolonged effect of acetylcholine.
|
Tacrine is rapidly absorbed. Absolute bioavailability of tacrine is approximately 17%.
|
Hepatic. Cytochrome P450 1A2 is the principal isozyme involved in tacrine metabolism. The major metabolite, 1-hydroxy-tacrine (velnacrine), has central cholinergic activity.
|
Overdosage with cholinesterase inhibitors can cause a cholinergic crisis characterized by severe nausea/vomiting, salivation, sweating, bradycardia, hypotension, collapse, and convulsions. Increasing muscle weakness is a possibility and may result in death if respiratory muscles are involved. The estimated median lethal dose of tacrine following a single oral dose in rats is 40 mg/kg, or approximately 12 times the maximum recommended human dose of 160 mg/day.
|
2 to 4 hours
|
55%
| null |
* 349 ± 193 L
| null |
Organic compounds
|
Organoheterocyclic compounds
|
Quinolines and derivatives
|
Benzoquinolines
|
[
"approved",
"investigational",
"withdrawn"
] |
[
"N06DA",
"N06D",
"N06",
"N"
] |
[
"Humans and other mammals"
] |
[
{
"cost": "3.03",
"description": "Cognex 10 mg capsule",
"unit": "capsule"
},
{
"cost": "3.03",
"description": "Cognex 20 mg capsule",
"unit": "capsule"
},
{
"cost": "3.03",
"description": "Cognex 40 mg capsule",
"unit": "capsule"
}
] |
[] |
1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrahydro-9-aminoacridine | 1,2,3,4-tetrahydroacridin-9-amine | 5-amino-6,7,8,9-tetrahydroacridine | 9-amino-1,2,3,4-tetrahydroacridine | Tacrin | Tacrine | Tacrinum | Tetrahydroaminacrine | Tetrahydroaminoacridine | THA | 3.1.1.8 | Acylcholine acylhydrolase | Butyrylcholine esterase | CHE1 | Choline esterase II | Pseudocholinesterase | 3.1.1.7 | AChE | ACAT | Acyl-coenzyme A:cholesterol acyltransferase | Brain carboxylesterase hBr1 | Carboxylesterase 1 | CE-1 | CEH | CES2 | Cholesteryl ester hydrolase | Cocaine carboxylesterase | Egasyn | hCE-1 | HMSE | Methylumbelliferyl-acetate deacetylase 1 | Monocyte/macrophage serine esterase | REH | Retinyl ester hydrolase | Serine esterase 1 | SES1 | TGH | Triacylglycerol hydrolase | 1.14.14.1 | Cholesterol 25-hydroxylase | CYPIA2 | Cytochrome P(3)450 | Cytochrome P450 4 | Cytochrome P450-P3 | Hydroperoxy icosatetraenoate dehydratase | ATP-binding cassette sub-family B member 1 | MDR1 | Multidrug resistance protein 1 | P-glycoprotein 1 | PGY1 | Phospholipid transporter ABCB1
|
[
"Cognex",
"Cognex",
"Cognex",
"Cognex"
] |
[
"Talem"
] |
[] |
[
"P06276",
"P22303",
"P23141"
] |
[
"P05177"
] |
[] |
[
"P08183"
] |
DB00383
|
Oxyphencyclimine
|
Oxyphencyclimine is an anticholinergic drug (trade name Daricon) used in treating peptic ulcers.
|
solid
|
For the treatment of peptic ulcer disease and the relief of smooth muscle spasms in gastrointestinal disorders.
|
Oxyphencyclimine is a synthetic anticholinergic agent which has been shown in experimental and clinical studies to have a pronounced antispasmodic and antisecretory effect on the gastrointestinal tract. Oxyphencyclimine is an antimuscarinic, anticholinergic drug.
|
Oxyphencyclimine binds the muscarinic acetylcholine receptor. It may block all three types of muscarinic receptors including M-1 receptors in the CNS and ganglia, M-2 receptors in the heart (vagus) and M-3 receptors at the parasympathetic NEJ system. The muscarinic acetylcholine receptors mediate various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Oxphencyclimine inhibits vagally mediated reflexes by antagonizing the action of acetylcholine. This in turn reduces the secretion of gastric acids in the stomach.
| null | null | null | null | null | null | null | null |
Organic compounds
|
Organoheterocyclic compounds
|
Diazines
|
Pyrimidines and pyrimidine derivatives
|
[
"approved"
] |
[
"A03AA",
"A03A",
"A03",
"A",
"A03CA",
"A03C",
"A03",
"A"
] |
[
"Humans and other mammals"
] |
[
{
"cost": "30.0",
"description": "Oxyphencyclimine hcl powder",
"unit": "g"
}
] |
[] |
Oxifencicliminum | Oxyphencyclimine | Oxyphencycliminum
|
[] |
[
"Proclimine"
] |
[] |
[
"P08912",
"P20309",
"P11229",
"P08172"
] |
[] |
[] |
[] |
DB00384
|
Triamterene
|
Triamterene (2,4,7-triamino-6-phenylpteridine) is a potassium-sparing diuretic that is used in the management of hypertension. It works by promoting the excretion of sodium ions and water while decreasing the potassium excretion in the distal part of the nephron in the kidneys by working on the lumenal side.[A177985] Since it acts on the distal nephron where only a small fraction of sodium ion reabsorption occurs, triamterene is reported to have limited diuretic efficacy.[T28] Due to its effects on increased serum potassium levels, triamterene is associated with a risk of producing hyperkalemia. Triamterene is a weak antagonist of folic acid, and a photosensitizing drug.[L6163]
Triamterene was approved by the Food and Drug Administration in the U.S. in 1964.[L6163] Currently, triamterene is used in the treatment of edema associated with various conditions as monotherapy and is approved for use with other diuretics to enhance diuretic and potassium-sparing effects.[L6166] It is also found in a combination product with hydrochlorothiazide that is used for the management of hypertension or treatment of edema in patients who develop hypokalemia on hydrochlorothiazide alone.
|
solid
|
Triamterene is indicated for the treatment of edema associated with congestive heart failure, cirrhosis of the liver, and the nephrotic syndrome; also in steroid-induced edema, idiopathic edema, and edema due to secondary hyperaldosteronism.[L6166]
Triamterene in combination with hydrochlorothiazide is indicated for the managment of hypertension or treatment of edema in patients who develop hypokalemia following hydrochlorothiazide monotherapy, and in patients who require thiazide diuretic and in whom the development of hypokalemia cannot be risked.[L6169] Triamterene allows the maintenance of potassium balance when given in combination with loop diuretics and thiazides.[T28]
|
Triamterene, a relatively weak, potassium-sparing diuretic and antihypertensive, is used in the management of hypertension and edema. It primarily works on the distal nephron in the kidneys; it acts from the late distal tubule to the collecting duct to inhibit Na+ reabsorption and decreasing K+ excretion.[T28] As triamterene tends to conserve potassium more strongly than promoting Na+ excretion, it can cause an increase in serum potassium, which may result in hyperkalemia potentially associated with cardiac irregularities.[L6166] In healthy volunteers administered with oral triamterene, there was an increase in the renal clearnace of sodium and magnesium, and a decrease in the clearance of uric acid and creatinine[A178039] due to its effect of reducing glomerular filtration renal plasma flow.[L6169] Triamterene does not affect calcium excretion.[L6169] In clinical trials, the use of triamterene in combination with hydrochlorothiazide resulted an enhanced blood pressure-lowering effects of hydrochlorothiazide.[A178048]
|
Triamterene inhibits the epithelial sodium channels (ENaC) located on the lumenal side in the late distal convoluted tubule and collecting tubule [A178042], which are transmembrane channels that normally promote sodium uptake and potassium secretion.[A178048] In the late distal tubule to the collecting duct, sodium ions are actively reabsorbed via ENaC on the luminal membrane and are extruded out of the cell into the peritubular medium by a sodium-potassium exchange pump, the Na-K-ATPase,[A178054] with water following passively.[T28] Triamterene exerts a diuretic effect on the distal renal tubule to inhibit the reabsorption of sodium ions in exchange for potassium and hydrogen ions and its natriuretic activity is limited by the amount of sodium reaching its site of action.[L6169] Its action is antagonistic to that of adrenal mineralocorticoids, such as aldosterone, but it is not an inhibitor or antagonist of aldosterone.[L6166] Triamterene maintains or increases sodium excretion, thereby increasing the excretion of water, and reducing the excess loss of potassium, hydrogen, and chloride ions by inhibiting the distal tubular exchange mechanism.[L6169] Due to its diuretic effect, triamterene rapidly and reversibly reduces the lumen-negative transepithelial potential difference by almost completely abolishing Na+ conductance without altering K+ conductance.[A177988] This reduces the driving force for potassium movement into the tubular lumen and thus decreases potassium excretion. [A178054] Triamterene is similar in action to [amiloride] but, unlike amiloride, increases the urinary excretion of magnesium.[A178039]
|
Triamterene is shown to be rapidly absorbed in the gastrointestinal tract [L6166,T28] Its onset of action achiveved within 2 to 4 hours after oral ingestion [L6166] and its duration of action is 12-16 hours.[T28] It is reported that the diuretic effect of triamterene may not be observed for several days after administration.[L6166] In a pharmacokinetic study, the oral bioavailability of triamterene was determined to be 52%.[A178012] Following administration of a single oral dose to fasted healthy male volunteers, the mean AUC of triamterene was about 148.7 ng*hr/mL [L6169] and the mean peak plasma concentrations (Cmax) were 46.4 ng/mL reached at 1.1 hour after administration.[L6169] In a limited study, administration of triamterene in combination with hydrochlorothiazide resulted in an increased bioavailability of triamterene by about 67% and a delay of up to 2 hours in the absorption of the drug.[L6169] It is advised that triamterene is administered after meals; in a limited study, combination use of triamterene and hydrochlorothiazide with the consumption of a high-fat meal resulted in an increase in the mean bioavailability and peak serum concentrations of triamterene and its active sulfate metabolite, as well as a delay of up to 2 hours in the absorption of the active constituents.[L6169]
|
Triamterene undergoes phase I metabolism involving hydroxylation, via CYP1A2 activity, to form 4'-hydroxytriamterene. 4'-Hydroxytriamterene is further transformed in phase II metabolism mediated by cytosolic sulfotransferases to form the major metabolite, 4′-hydroxytriamterene sulfate, which retains a diuretic activity. [A39120,L6163] Both the plasma and urine levels of this metabolite greatly exceed triamterene levels [L6166] while the renal clearance of the sulfate conjugate was les than that of triamterene; this low renal clearance of the sulfate conjugate as compared with triamterene may be explained by the low unbound fraction of the metabolite in plasma.[A178057]
|
Acute oral LD50 of triamterene in rats is 400 mg/kg and 285-380 mg/kg in mice.[L6166,MSDS] There has been a case of reversible acute renal failure following ingestion of 50 combination pills containing 50 mg triamterene and 25 mg hydrochlorothiazide. Symptoms of overdose, such as nausea, vomiting, gastrointestinal disturbances, weakness, and hypotension, are related to electrolyte imbalances, such as hyperkalemia. As there is no specific antidote, emesis and gastric lavage should be use to induce immediate evacuation of the stomach and careful evaluation of the electrolyte pattern and fluid balance should be made. Dialysis may be somewhat effective in case of an overdosage.[L6166]
In a carciongenicity study in male and female mice administered with triamterene at the highst dosage level, there was an increased incidence of hepatocellular neoplasia, primarily adenomas. However, this was not a dose-dependent phenomenon and there was no statistically significant difference from control incidence at any dose level. In bacterial assays, there was no demonstrated mutagenic potential of triamterene. In in vitro assay using Chinese hamster ovary (CHO) cells with or without metabolic activation, there were no chromosomal aberrations. Studies evaluating the effects of triamterene on reproductive system or fertility have not been conducted. It is advised that the use of triamterene is avoided during pregnancy. As triamterene has been detected in human breast milk, triamterene should be used when nursing is ceased.[L6166]
|
The half-life of the drug in plasma ranges from 1.5 to 2 hours.[L6193] In a pharmacokinetic study involving healthy volunteers, the terminal half-lives for triamterene and 4′-hydroxytriamterene sulfate were 255 ± 42 and 188 ± 70 minutes, respectively, after intravenous infusion of the parent drug.[A577,L6163]
|
67% bound to proteins. [L6166]
|
Triamterene and its metabolites are excreted by the kidney by filtration and tubular secretion.[L6193] Upon oral ingestion, somewhat less than 50% of the oral dose reaches the urine.[L6166] About 20% of an oral dose appears unchanged in the urine, 70% as the sulphate ester of hydroxytriamterene and 10% as free hydroxytriamterene and triamterene glucuronide.[L6193]
|
In a pharmacolinetic study involving healthy volunteers receiving triamterene intravenously, the volumes of distribution of the central compartment of triamterene and its hydroxylated ester metabolite were 1.49 L/kg and 0.11 L/kg, respectively.[A577] Triamterene was found to cross the placental barrier and appear in the cord blood of animals.[L6166]
|
The total plasma clearance was 4.5 l/min and renal plasma clearance was 0.22 l/kg following intravenous administration of triamterene in healthy volunteers.[A577]
|
Organic compounds
|
Organoheterocyclic compounds
|
Pteridines and derivatives
| null |
[
"approved"
] |
[
"C03DB",
"C03D",
"C03",
"C"
] |
[
"Humans and other mammals"
] |
[] |
[] |
6-phenylpteridine-2,4,7-triamine | Teridin | Triamteren | Triamterena | Triamtérène | Triamterene | Triamtereno | Triamterenum | ENaCG | Epithelial Na(+) channel subunit gamma | Gamma-ENaC | Gamma-NaCH | Nonvoltage-gated sodium channel 1 subunit gamma | SCNEG | Alpha-ENaC | Alpha-NaCH | ENaCA | Epithelial Na(+) channel subunit alpha | Nonvoltage-gated sodium channel 1 subunit alpha | SCNEA | SCNN1 | Beta-ENaC | Beta-NaCH | ENaCB | Epithelial Na(+) channel subunit beta | Nonvoltage-gated sodium channel 1 subunit beta | SCNEB | Delta-ENaC | Delta-NaCH | DNACH | ENaCD | Epithelial Na(+) channel subunit delta | Nonvoltage-gated sodium channel 1 subunit delta | SCNED | 1.14.14.1 | Cholesterol 25-hydroxylase | CYPIA2 | Cytochrome P(3)450 | Cytochrome P450 4 | Cytochrome P450-P3 | Hydroperoxy icosatetraenoate dehydratase
|
[
"Apo Triazide",
"Dyazide",
"Dyazide",
"Dyazide",
"Dyazide",
"Dyazide",
"Dyazide Tab",
"Dyrenium",
"Dyrenium",
"Dyrenium",
"Dyrenium",
"Dyrenium",
"Dyrenium",
"Dyrenium 100",
"Dyrenium 50",
"Maxzide",
"Maxzide",
"Maxzide-25",
"Maxzide-25",
"Nu-triazide Tab 50 Mg/25 mg",
"Penta-triamterene Hctz Tablets",
"Pro-triazide",
"Riva-zide 50/25mg Tablets",
"Teva-triamterene/hctz",
"Triamterene",
"Triamterene",
"Triamterene",
"Triamterene",
"Triamterene",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene hydrochlorothiazide",
"Triamterene hydrochlorothiazide",
"Triamterene hydrochlorothiazide",
"Triamterene hydrochlorothiazide",
"Triamterene hydrochlorothiazide",
"Triamterene hydrochlorothiazide",
"Triamterene hydrochlorothiazide",
"Triamterene hydrochlorothiazide",
"Triamterene hydrochlorothiazide",
"Triamterene hydrochlorothiazide",
"Triamterene hydrochlorothiazide",
"Triamterene hydrochlorothiazide",
"Triamterene hydrochlorothiazide",
"Triamterene hydrochlorothiazide",
"Triamterene hydrochlorothiazide",
"Triamterene hydrochlorothiazide",
"Triamterene hydrochlorothiazide",
"Triamterene hydrochlorothiazide",
"Triamterene hydrochlorothiazide",
"Triamterene hydrochlorothiazide",
"Triamterene hydrochlorothiazide",
"Triamterene hydrochlorothiazide"
] |
[
"Diuteren",
"Dytac",
"Riyazine",
"Triteren",
"Urinis"
] |
[
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene hydrochlorothiazide",
"Triamterene hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Maxzide-25",
"Maxzide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Dyazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene hydrochlorothiazide",
"Triamterene hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene hydrochlorothiazide",
"Triamterene hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Dyazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Maxzide-25",
"Maxzide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene hydrochlorothiazide",
"Triamterene hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene hydrochlorothiazide",
"Triamterene hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Dyazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene hydrochlorothiazide",
"Triamterene hydrochlorothiazide",
"Dyazide",
"Triamterene hydrochlorothiazide",
"Triamterene hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene hydrochlorothiazide",
"Triamterene hydrochlorothiazide",
"Dyazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Teva-triamterene/hctz",
"Apo Triazide",
"Nu-triazide Tab 50 Mg/25 mg",
"Dyazide Tab",
"Penta-triamterene Hctz Tablets",
"Riva-zide 50/25mg Tablets",
"Pro-triazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide",
"Triamterene and Hydrochlorothiazide"
] |
[
"P51170",
"P37088",
"P51168",
"P51172"
] |
[
"P05177"
] |
[] |
[] |
DB00385
|
Valrubicin
|
Valrubicin (N-trifluoroacetyladriamycin-14-valerate) is a chemotherapy drug commonly marketed under the trade name VALSTAR. It is a semisynthetic analog of the [doxorubicin], which is an anthracycline drug. Used in the treatment of the bladder cancer, valrubicin is administered by direct infusion into the bladder.
|
solid
|
For the treatment of cancer of the bladder.
|
Valrubicin is an anticancer agent.
|
Valrubicin is an anthracycline that affects a variety of inter-related biological functions, most of which involve nucleic acid metabolism. It readily penetrates into cells, where after DNA intercalation, it inhibits the incorporation of nucleosides into nucleic acids, causes extensive chromosomal damage, and arrests cell cycle in G2. Although valrubicin does not bind strongly to DNA, a principal mechanism of its action, mediated by valrubicin metabolites, is interference with the normal DNA breaking-resealing action of DNA topoisomerase II.
| null |
Valrubicin is metabolized to two primary metabolites: N-trifluoroacetyladriamycin and N-trifluoroacetyladriamycinol.
|
The primary anticipated complications of overdosage associated with intravesical administration would be consistent with irritable bladder symptoms. Myelosuppression is possible if valrubicin is inadvertently administered systemically or if significant systemic exposure occurs following intravesical administration (e.g., in patients with bladder/rupture perforation). The maximum tolerated dose in humans by either intraperitoneal or intravenous administration is 600 mg/m<sup>2</sup>.
| null |
>99%
| null | null | null |
Organic compounds
|
Phenylpropanoids and polyketides
|
Anthracyclines
| null |
[
"approved"
] |
[
"L01DB",
"L01D",
"L01",
"L"
] |
[
"Humans and other mammals"
] |
[
{
"cost": "219.96",
"description": "Valstar 40 mg/ml vial",
"unit": "ml"
}
] |
[] |
(8S, 10S)-8-glycoloyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-10-[[2,3,6-trideoxy-3-(2,2,2-trifluoroacetamido)-α-L-lyxo-hexopyranosyl]oxy]-5,12-naphthacenedione 8²-valerate | 2-oxo-2-[(2S,4S)-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-4-({2,3,6-trideoxy-3-[(trifluoroacetyl)amino]hexopyranosyl}oxy)-1,2,3,4,6,11-hexahydrotetracen-2-yl]ethyl pentanoate | Valrubicin | Valrubicina | Valrubicine | Valrubicinum | 5.6.2.2 | DNA topoisomerase II, beta isozyme | 5.6.2.2 | DNA topoisomerase II, alpha isozyme | TOP2
|
[
"Valrubicin Intravesical Solution",
"Valstar",
"Valtaxin"
] |
[] |
[] |
[
"Q02880",
"P11388"
] |
[] |
[] |
[] |
DB00387
|
Procyclidine
|
A muscarinic antagonist that crosses the blood-brain barrier and is used in the treatment of drug-induced extrapyramidal disorders and in parkinsonism.
|
solid
|
For the treatment of all forms of Parkinson's Disease, as well as control of extrapyramidal reactions induced by antipsychotic agents.
|
Procyclidine has an atropine-like action on parasympathetic-innervated peripheral structures including smooth muscle. It's antispasmodic effects are thought to be related to the blockage of central cholinergic receptors M1, M2 and M4. It is used to treat symptomatic Parkinsonism and extrapyramidal dysfunction caused by antipsychotic agents.
|
The mechanism of action is unknown. It is thought that Procyclidine acts by blocking central cholinergic receptors, and thus balancing cholinergic and dopaminergic activity in the basal ganglia. Many of its effects are due to its pharmacologic similarities with atropine. Procyclidine exerts an antispasmodic effect on smooth muscle, and may produce mydriasis and reduction in salivation.
| null | null |
LD<sub>50</sub>=60 mg/kg (IV in mice)
| null |
Approximately 100% bound to albumin.
| null | null | null |
Organic compounds
|
Organic nitrogen compounds
|
Organonitrogen compounds
|
Amines
|
[
"approved"
] |
[
"N04AA",
"N04A",
"N04",
"N"
] |
[
"Humans and other mammals"
] |
[
{
"cost": "0.03",
"description": "Pms-Procyclidine 0.5 mg/ml Elixir",
"unit": "ml"
},
{
"cost": "0.03",
"description": "Pms-Procyclidine 5 mg Tablet",
"unit": "tablet"
},
{
"cost": "0.06",
"description": "Pms-Procyclidine 2.5 mg Tablet",
"unit": "tablet"
}
] |
[] |
1-cyclohexyl-1-phenyl-3-pyrrolidin-1-yl-propan-1-ol hydrochloride | 1-Cyclohexyl-1-phenyl-3-pyrrolidino-1-propanol | Prociclidina | Procyclidin | Procyclidine | Procyclidinum | Tricyclamol
|
[
"Kemadrin",
"Kemadrin Elx",
"Kemadrin Tab 5mg",
"Pdp-procyclidine",
"Pdp-procyclidine",
"Pdp-procyclidine",
"Pendo-procyclidine",
"PHL-procyclidine Tablets",
"PHL-procyclidine Tablets",
"Procyclid Elx",
"Procyclid Tab 5mg"
] |
[
"Arpicolin",
"Extranil",
"Kdrine",
"Kemadren",
"Osnervan",
"Prodine",
"Proimer"
] |
[] |
[
"P20309",
"P08912",
"P11229",
"P08172",
"P08173"
] |
[] |
[] |
[] |
DB00388
|
Phenylephrine
|
Phenylephrine is an alpha-1 adrenergic receptor agonist used to treat hypotension,[L9416,L9410] dilate the pupil,[L9413] and induce local vasoconstriction.[A187370] The action of phenylephrine, or neo-synephrine, was first described in literature in the 1930s.[A187376]
Phenylephrine was granted FDA approval in 1939.[L9413]
|
solid
|
Phenylephrine is available in various drug formulations, which have different indications. Phenylephrine injections are indicated to treat hypotension caused by shock or anesthesia.[L9416, L9410] The ophthalmic formulation is indicated to induce mydriasis [L9413, L46332] and conjunctival vasoconstriction.[A187370] The intranasal formulation is used to treat congestion, and a topical formulation is used to treat hemorrhoids.[A187370] Off-label uses include priapism and induction of local vasoconstriction.[A187370]
|
Phenylephrine is an alpha-1 adrenergic agonist that raises blood pressure,[L9416,L9410] dilates the pupils,[L9413] and causes local vasoconstriction.[A187370] Ophthalmic formulations of phenylephrine act for 3-8 hours[L9413] while intravenous solutions have an effective half life of 5 minutes and an elimination half life of 2.5 hours.[A187379,L9416] Patients taking ophthalmic formulations of phenylephrine should be counselled about the risk of arrhythmia, hypertension, and rebound miosis.[L9413] Patients taking an intravenous formulation should be counselled regarding the risk of bradycardia, allergic reactions, extravasation causing necrosis or tissue sloughing, and the concomitant use of oxytocic drugs.[L9416,L9410]
|
Phenylephrine is an alpha-1 adrenergic agonist that mediates vasoconstriction[A187370] and mydriasis[L9413] depending on the route and location of administration. Systemic exposure to phenylephrine also leads to agonism of alpha-1 adrenergic receptors, raising systolic and diastolic pressure as well as peripheral vascular resistance.[L9416,L9410] Increased blood pressure stimulates the vagus nerve, causing reflex bradycardia.[L9416,L9410]
|
Phenylephrine is 38% orally bioavailable.[A187379] Clinically significant systemic absorption of ophthalmic formulations is possible, especially at higher strengths and when the cornea is damaged.[L9416]
|
Phenylephrine is mainly metabolized by monoamine oxidase A, monoamine oxidase B, and SULT1A3.[A187382,A187385,L9416,L9410] The major metabolite is the inactive meta-hydroxymandelic acid, followed by sulfate conjugates.[A187385,L9416,L9410] Phenylephrine can also be metabolized to phenylephrine glucuronide.[A187385]
|
Patients experiencing and overdose may present with headache, hypertension, reflex bradycardia, tingling limbs, cardiac arrhythmias, and a feeling of fullness in the head.[L9416,L9413,L9410] Overdose may be treated by supportive care and discontinuing phenylephrine, chronotropic medications, and vasodilators.[A187370] Subcutaneous phentolamine may be used to treat tissue extravasation.[A187370,L9413]
|
Intravenous phenylephrine has an effective half life of 5 minutes and an elimination half life of 2.5 hours.[A187379,L9416,L9410]
|
Data regarding the protein binding of phenylephrine in serum is not readily available.[L9416,L9413,L9410]
|
86% of a dose of phenylephrine is recovered in the urine[A187379] with 16% as the unmetabolized drug, 57% as the inactive meta-hydroxymendelic acid, and 8% as inactive sulfate conjugates.[L9416,L9410]
|
The volume of distribution of phenylephrine is 340L.[L9416,L9410]
|
Phenylephrine has an average clearance of 2100mL/min.[L9416,L9410]
|
Organic compounds
|
Benzenoids
|
Phenols
|
1-hydroxy-4-unsubstituted benzenoids
|
[
"approved"
] |
[
"S01FB",
"S01F",
"S01",
"S",
"R01AB",
"R01A",
"R01",
"R",
"C01CA",
"C01C",
"C01",
"C",
"R01AA",
"R01A",
"R01",
"R",
"C05AX",
"C05A",
"C05",
"C",
"S01FB",
"S01F",
"S01",
"S",
"S01GA",
"S01G",
"S01",
"S",
"R01BA",
"R01B",
"R01",
"R",
"S01GA",
"S01G",
"S01",
"S",
"R01BA",
"R01B",
"R01",
"R"
] |
[
"Humans and other mammals"
] |
[
{
"cost": "1.09",
"description": "Mydfrin 2.5 % Solution",
"unit": "ml"
},
{
"cost": "1.17",
"description": "Phenylephrine-ns 0.4 mg/10 ml",
"unit": "ml"
},
{
"cost": "1.2",
"description": "Phenylephrine-ns 0.8 mg/10 ml",
"unit": "ml"
},
{
"cost": "1.25",
"description": "Phenylephrine 10% eye drops",
"unit": "ml"
},
{
"cost": "1.34",
"description": "Ak-dilate 10% eye drops",
"unit": "ml"
},
{
"cost": "1.34",
"description": "Phenylephrine hcl crystals",
"unit": "g"
},
{
"cost": "1.93",
"description": "Neofrin 10% eye drops",
"unit": "ml"
},
{
"cost": "2.09",
"description": "Phenylephrine 2.5% eye drop",
"unit": "ml"
},
{
"cost": "3.0",
"description": "Phenylephrine 10 mg/ml vial",
"unit": "ml"
},
{
"cost": "5.28",
"description": "Mydfrin 2.5% eye drops",
"unit": "ml"
},
{
"cost": "5.68",
"description": "Neo-synephrine 10 mg/ml amp",
"unit": "ml"
},
{
"cost": "37.1",
"description": "Mydfrin 2.5% Solution 5ml Bottle",
"unit": "bottle"
},
{
"cost": "0.03",
"description": "Pv nasal decongestant 5 mg tablet",
"unit": "tablet"
},
{
"cost": "0.05",
"description": "Non-pseudo sinus decongest tablet",
"unit": "tablet"
},
{
"cost": "0.07",
"description": "Rhinall 0.25% nose drops",
"unit": "ml"
},
{
"cost": "0.08",
"description": "Phenylephrine 10 mg tablet",
"unit": "tablet"
},
{
"cost": "0.15",
"description": "Ephrine 1% nose drops",
"unit": "ml"
},
{
"cost": "0.17",
"description": "Industrial 0.12% eye drops",
"unit": "ml"
},
{
"cost": "0.21",
"description": "Tur-bi-kal nose drops",
"unit": "ml"
},
{
"cost": "0.22",
"description": "Little noses decon nose drp",
"unit": "ml"
},
{
"cost": "0.22",
"description": "Wal-phed pe 10 mg tablet",
"unit": "tablet"
},
{
"cost": "0.23",
"description": "Neo-synephrine 0.5% drops",
"unit": "ml"
},
{
"cost": "0.25",
"description": "Sudafed pe 10 mg tablet",
"unit": "tablet"
},
{
"cost": "0.26",
"description": "Neo-synephrine 1% drops",
"unit": "ml"
},
{
"cost": "0.28",
"description": "Hemorrhoidal suppository",
"unit": "suppository"
},
{
"cost": "0.28",
"description": "Neo-synephrine 12 hour spray",
"unit": "ml"
},
{
"cost": "0.36",
"description": "Neo-synephrine 0.25% drops",
"unit": "ml"
},
{
"cost": "0.45",
"description": "Ak-dilate 2.5% eye drops",
"unit": "ml"
},
{
"cost": "0.6",
"description": "Neofrin 2.5% eye drops",
"unit": "ml"
}
] |
[
{
"approved": "2012-05-08",
"country": "United States",
"expires": "2024-01-30",
"number": "8173707"
},
{
"approved": "2016-03-08",
"country": "United States",
"expires": "2024-01-30",
"number": "9278101"
},
{
"approved": "2013-11-19",
"country": "United States",
"expires": "2024-01-30",
"number": "8586633"
},
{
"approved": "2015-06-30",
"country": "United States",
"expires": "2034-04-23",
"number": "9066856"
},
{
"approved": "2014-10-14",
"country": "United States",
"expires": "2033-11-14",
"number": "8859623"
},
{
"approved": "2016-07-26",
"country": "United States",
"expires": "2024-01-30",
"number": "9399040"
},
{
"approved": "2016-11-08",
"country": "United States",
"expires": "2034-04-23",
"number": "9486406"
},
{
"approved": "2018-01-02",
"country": "United States",
"expires": "2033-10-23",
"number": "9855246"
},
{
"approved": "2016-09-26",
"country": "United States",
"expires": "2036-09-26",
"number": "11213480"
},
{
"approved": "2016-08-05",
"country": "United States",
"expires": "2036-08-05",
"number": "11471400"
},
{
"approved": "2011-07-15",
"country": "United States",
"expires": "2031-07-15",
"number": "11398306"
},
{
"approved": "2020-11-17",
"country": "United States",
"expires": "2031-07-15",
"number": "10839960"
},
{
"approved": "2011-07-15",
"country": "United States",
"expires": "2031-07-15",
"number": "11839487"
}
] |
(−)-m-hydroxy-α-(methylaminomethyl)benzyl alcohol | Fenilefrina | l-(3-Hydroxyphenyl)-N-methylethanolamine | Phenylephrine | Phenylephrinum | R(-)-Phenylephrine | ADRA1C | Alpha-1A adrenoceptor | Alpha-1A adrenoreceptor | Alpha-1C adrenergic receptor | Alpha-adrenergic receptor 1c | Dopamine D2 receptor | Alpha-1B adrenoceptor | Alpha-1B adrenoreceptor | ADRA1A | Alpha-1A adrenergic receptor | Alpha-1D adrenoceptor | Alpha-1D adrenoreceptor | Alpha-adrenergic receptor 1a | 1.4.3.21 | 1.4.3.4 | MAO-A | Monoamine oxidase type A | 1.4.3.21 | 1.4.3.4 | MAO-B | Monoamine oxidase type B | 2.8.2.1 | Aryl sulfotransferase 1A3/1A4 | Catecholamine-sulfating phenol sulfotransferase | HAST3 | M-PST | Monoamine-sulfating phenol sulfotransferase | Placental estrogen sulfotransferase | ST1A3 | STM | Sulfotransferase 1A3/1A4 | Sulfotransferase, monoamine-preferring | Thermolabile phenol sulfotransferase | TL-PST | 1.14.14.1 | Cholesterol 25-hydroxylase | CYPIA2 | Cytochrome P(3)450 | Cytochrome P450 4 | Cytochrome P450-P3 | Hydroperoxy icosatetraenoate dehydratase
|
[
"24/7 Life Cold and Flu DayTime Severe",
"4 Way Fast Acting",
"4248 First Aid Kit",
"4356 First Aid Kit",
"4390 First Aid Kit",
"4392 First Aid Kit",
"7 Select Cold and Allergy Childrens",
"7 Select Day Time Relief",
"7 Select Day Time Relief",
"7 Select Hemorrhoidal Original Strength",
"7 Select Nasal Decongestant PE",
"7 Select Night Time Severe Cold Cough and Flu",
"7 Select Night Time severe cold, cough and flu",
"A-Tan 12X Suspension",
"Accu Tuss DM",
"AccuHist",
"AccuHist PDX",
"AcetaFlu DayTime",
"AcetaFlu DayTime Effervescent",
"AcetaFlu NightTime",
"AcetaFlu NightTime Effervescent",
"Acetaminophen 500mg, Dextromethorphan HBr 10mg, Guaifenesin 200mg, Phenylephrine HCl 5mg",
"Acetaminophen Congestion and Pain",
"Acetaminophen Dextromethorphan HBr Doxylamine succinate Phenylephrine HCl",
"Acetaminophen Dextromethorphan HBr Doxylamine succinate Phenylephrine HCl",
"Acetaminophen Dextromethorphan HBr Guaifenesin Phenylephrine HCl",
"ACETAMINOPHEN DEXTROMETHORPHAN HYDROBROMIDE and PHENYLEPHRINE HYDROCHLORIDE",
"Acetaminophen Dextromethorphan Hydrobromide Doxylamine Succinate Phenylephrine Hydrochloride",
"Acetaminophen Dextromethorphan Hydrobromide Doxylamine Succinate Phenylephrine hydrochloride",
"Acetaminophen Dextromethorphan Hydrobromide Phenylephrine Hydrochloride",
"Acetaminophen Dextromethorphan Hydrobromide Phenylephrine Hydrochloride",
"Acetaminophen Phenylephrine HCl",
"Acetaminophen Phenylephrine HCl",
"Acetaminophen Sinus Congestion and Pain A P J Coated",
"Acetaminophen Sinus Congestion and Pain Daytime",
"Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hydrobromide, Phenylephrine Hydrochloride",
"Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hydrobromide, Phenylephrine Hydrochloride",
"Acetaminophen, Chlorpheniramine Maleate, Phenylephrine HCl",
"Acetaminophen, Chlorpheniramine Maleate, Phenylephrine HCl",
"Acetaminophen, Chlorpheniramine Maleate, Phenylephrine HCl",
"Acetaminophen, Chlorpheniramine Maleate, Phenylephrine Hydrochloride",
"Acetaminophen, Chlorpheniramine Maleate, Phenylephrine Hydrochloride",
"ACETAMINOPHEN, DEXTROMETHORPHAN HBr, GUAILFENESIN,PHENLYEPHRINE HCL",
"Acetaminophen, Dextromethorphan HBr, Phenylephrine HCl, Doxylamine Succinate",
"ACETAMINOPHEN, DEXTROMETHORPHAN HYDROBROMIDE, and PHENYLEPHRINE HYDROCHLORIDE",
"Acetaminophen, Dextromethorphan Hydrobromide, Guaifenesin, Phenylephrine Hydrochloride",
"Acetaminophen, Dextromethorphan Hydrobromide, Guaifenesin, Phenylephrine Hydrochloride",
"Acetaminophen, Dextromethorphan Hydrobromide, Guaifenesin, Phenylephrine Hydrochloride",
"Acetaminophen, Dextromethorphan Hydrobromide, Guaifenesin, Phenylephrine Hydrochloride",
"Acetaminophen, Dextromethorphan Hydrobromide, Phenylephrine Hydrochloride",
"Acetaminophen, Dextromethorphan Hydrobromide, Phenylephrine Hydrochloride",
"Acetaminophen, Dextromethorphan Hydrobromide, Phenylephrine Hydrochloride",
"Acetaminophen, Diphenhydramine Hydrochloride, Phenylephrine Hydrochloride",
"Acetaminophen, Diphenhydramine Hydrochloride, Phenylephrine Hydrochloride",
"Acetaminophen, Diphenhydramine Hydrochloride, Phenylephrine Hydrochloride",
"Acetaminophen, Diphenhydramine Hydrochloride, Phenylephrine Hydrochloride",
"Acetaminophen, Diphenhydramine Hydrochloride, Phenylephrine Hydrochloride",
"Acetaminophen, Diphenhydramine Hyhrochloride, Phenylephrine Hydrochloride",
"Acetaminophen, Guaifenesin, Dextromethorphan HBr, Phenylephrine HCl",
"Acetaminophen, Guaifenesin, Dextromethorphan HBr, Phenylephrine HCl",
"Acetaminophen, Phenylephrine Hydrochloride",
"Acetaminophen, Phenylephrine Hydrochloride",
"Acetaminophen, Phenylephrine Hydrochloride",
"Acetaminophen, Phenylephrine Hydrochloride, Chlorpheniramine Maleate",
"Acetaminophen, Phenylephrine Hydrochloride, Chlorpheniramine Maleate",
"Acetaminophen,Dextromethorphan,Phenylephrine",
"Acta Tabs PE",
"Acti PE",
"Actidom Da",
"Actidom Dmx",
"Actifed",
"Actifed PE",
"Actifed PE Plus",
"Actinel DM",
"Activcin",
"Adult CF Cough",
"Adult Cold, Flu and Sore Throat",
"Adult Cold, Flu and Sore Throat",
"Adult Severe Congestion and Cough",
"Adult Severe Congestion and Cough",
"Adult Tussin CF Multi-Symptom Cold",
"Adult Tussin Cough and Cold CF",
"Adult tussin Peak Cold Multi-Symptom Cold",
"Advil Allergy and Congestion Relief",
"Advil Allergy and Congestion Relief",
"Advil Allergy and Congestion Relief",
"Advil Allergy Congestion Relief",
"Advil Cold & Sinus PE",
"Advil Congestion Relief",
"Advil Congestion Relief",
"Advil Multi-Symptom Cold and Flu",
"Advil Sinus Congestion and Pain",
"Advil Sinus Congestion and Pain",
"Advil Sinus Congestion and Pain Relief",
"Airacof",
"Ala-hist Ac",
"Ala-hist PE",
"Alahist CF",
"Alahist D",
"Alahist DM",
"Alahist DM",
"Alahist DM",
"Alahist LQ",
"Alahist PE",
"Aldex CT",
"Aldex D",
"Algidol Flu",
"Algidol Flu",
"Alka Seltzer Plus 1s Blister Pack",
"Alka Seltzer Plus 2s Blister Pack",
"Alka Seltzer Plus Cold",
"Alka Seltzer Plus Cold",
"ALKA SELTZER PLUS Cold Day and Night Effervescent",
"Alka Seltzer Plus Maximum Strength Sinus, Allergy And Cough Power Max Gels",
"Alka Seltzer Plus Severe Cold and Flu PowerFast Fizz",
"Alka-Seltzer Plus",
"Alka-Seltzer Plus",
"Alka-Seltzer Plus Cold and Cough",
"Alka-Seltzer Plus Cold and Cough",
"Alka-Seltzer Plus Cold and Cough Cool Menthol",
"Alka-Seltzer Plus Cold and Cough Formula",
"Alka-Seltzer Plus Cold and Cough Formula",
"Alka-Seltzer Plus Cold and Flu",
"Alka-seltzer Plus Cold and Flu",
"Alka-Seltzer Plus Cold and Flu, BASIX",
"Alka-Seltzer Plus Cold and Flu, CVP",
"Alka-Seltzer Plus Cold Day and Night",
"Alka-Seltzer Plus Cold Day and Night",
"Alka-Seltzer Plus Cold Day and Night PowerMax gels",
"Alka-Seltzer Plus Cold Day and Night PowerMax gels",
"Alka-Seltzer Plus Cold Day and Night PowerMax gels",
"Alka-Seltzer Plus Cold Day and Night PowerMax gels",
"Alka-Seltzer Plus Cold Formula (Cherry Burst)",
"Alka-Seltzer Plus Cold Formula (Orange Zest)",
"Alka-Seltzer Plus Cold Medicine Sparkling Original",
"Alka-Seltzer Plus Cold Medicine Sparkling Original",
"Alka-Seltzer Plus Cold Night",
"Alka-Seltzer Plus Cold Orange Zest",
"Alka-Seltzer Plus Cold Sparkling Original",
"Alka-Seltzer Plus Cold Sparkling Original PowerFast Fizz",
"Alka-Seltzer Plus Cough, Mucus and Congestion Day and Night Powermax",
"Alka-Seltzer Plus Cough, Mucus and Congestion Day and Night Powermax",
"Alka-Seltzer Plus Day and Night Cold",
"Alka-Seltzer Plus Day and Night Cold",
"Alka-Seltzer Plus Day and Night Cold and Flu Formula",
"Alka-Seltzer Plus Day and Night Cold and Flu Formula",
"Alka-Seltzer Plus Day and Night Cold and Flu Formula",
"Alka-Seltzer Plus Day and Night Cold and Flu Formula",
"Alka-Seltzer Plus Day and Night Multi-Symptom Cold and Flu Formula",
"Alka-Seltzer Plus Day and Night Multi-Symptom Cold and Flu Formula",
"Alka-Seltzer Plus Day and Night Severe Cold and Flu",
"Alka-Seltzer Plus Day and Night Severe Cold and Flu",
"Alka-Seltzer Plus Day Cold and Flu",
"Alka-Seltzer Plus Day Non Drowsy Cold Medicine Citrus",
"Alka-Seltzer Plus Day Non-Drowsy Cold and Flu Formula",
"Alka-Seltzer Plus Day Severe Cold Plus Flu",
"Alka-Seltzer Plus Day Severe Cold, Cough And Flu",
"Alka-Seltzer Plus Fast Crystals Packs Cold Formula",
"Alka-Seltzer Plus Fast Packs Cold and Flu Formula",
"Alka-Seltzer Plus Flu Formula",
"Alka-Seltzer Plus Maximum Strength Cold and Cough",
"Alka-Seltzer Plus Maximum Strength Cold and Cough Liquid Gels with Cool Menthol Flavor Liquid Gels",
"Alka-Seltzer Plus Maximum Strength Cold and Cough Power Max Gels",
"Alka-Seltzer Plus Maximum Strength Cough, Mucus and Congestion Day and Night",
"Alka-Seltzer Plus Maximum Strength Cough, Mucus and Congestion Day and Night",
"Alka-Seltzer Plus Maximum Strength Cough, Mucus and Congestion Powermax",
"Alka-Seltzer Plus Maximum Strength Day and Night Cold and Flu",
"Alka-Seltzer Plus Maximum Strength Day and Night Cold and Flu",
"Alka-Seltzer Plus Maximum Strength Day and Night Cold and Flu",
"Alka-Seltzer Plus Maximum Strength Day and Night Cold and Flu",
"Alka-Seltzer Plus Maximum Strength Day and Night Cold and Flu",
"Alka-Seltzer Plus Maximum Strength Day and Night Cold and Flu",
"Alka-Seltzer Plus Maximum Strength Day and Night Cold and Flu PowerMax Gels",
"Alka-Seltzer Plus Maximum Strength Day and Night Cold and Flu PowerMax Gels",
"Alka-Seltzer Plus Maximum Strength Day and Night Cold and Flu PowerMax Gels",
"Alka-Seltzer Plus Maximum Strength Day and Night Cold and Flu PowerMax Gels",
"Alka-Seltzer Plus Maximum Strength Day Cold and Flu",
"Alka-Seltzer Plus Maximum Strength Day Cold and Flu PowerMax Gels",
"Alka-Seltzer Plus Maximum Strength Night Cold and Flu",
"Alka-Seltzer Plus Maximum Strength Night Cold and Flu PowerMax Gels",
"Alka-Seltzer Plus Maximum Strength Severe Sinus Congestion and Cough Day and Night",
"Alka-Seltzer Plus Maximum Strength Severe Sinus Congestion and Cough Day and Night",
"Alka-Seltzer Plus Maximum Strength Severe Sinus, Allergy and Cough",
"Alka-Seltzer Plus Maximum Strength Sinus Congestion and Pain PowerFast Fizz",
"Alka-Seltzer Plus Maximum Strength Sinus, Congestion and Pain Power Max Gels",
"Alka-Seltzer Plus Multi-Smptom Cold and Flu Night",
"Alka-Seltzer Plus Multi-Symptom Cold and Cough",
"Alka-Seltzer Plus Multi-Symptom Cold and Flu Day and Night Liquid Gels",
"Alka-Seltzer Plus Multi-Symptom Cold and Flu Day and Night Liquid Gels",
"Alka-Seltzer Plus Multi-Symptom Cold and Flu Day Liquid Gels",
"Alka-Seltzer Plus Multi-Symptom Cold Day and Night",
"Alka-Seltzer Plus Multi-Symptom Cold Day and Night",
"Alka-Seltzer Plus Multi-Symptom Cold Night",
"Alka-Seltzer Plus Night Cold and Flu Formula",
"Alka-Seltzer Plus Night Cold and Flu Formula",
"Alka-Seltzer Plus Night Cold Formula (Lemon)",
"Alka-Seltzer Plus Night Cold Medicine",
"Alka-Seltzer Plus Night Severe Cold and Flu",
"Alka-Seltzer Plus Night Severe Cold, Cough And Flu",
"Alka-Seltzer Plus Severe Allergy Sinus Congestion And Headache Formula",
"Alka-Seltzer Plus Severe Cold and Cough PowerFast Fizz",
"Alka-Seltzer Plus Severe Cold and Flu",
"Alka-Seltzer Plus Severe Cold And Flu Formula",
"Alka-Seltzer Plus Severe Cold and Flu PowerFast Fizz",
"Alka-Seltzer Plus Severe Cold and Flu PowerFast Fizz",
"Alka-Seltzer Plus Severe Cold and Flu PowerFast Fizz",
"Alka-Seltzer Plus Severe Cold and Flu PowerFast Fizz",
"Alka-Seltzer Plus Severe Cold Night PowerFast Fizz",
"Alka-Seltzer Plus Severe Cold Night PowerFast Fizz",
"Alka-Seltzer Plus Severe Cold Night PowerFast Fizz",
"Alka-Seltzer Plus Severe Cold PowerFast Fizz",
"Alka-Seltzer Plus Severe Cold PowerFast Fizz",
"Alka-Seltzer Plus Severe Cold PowerFast Fizz Day and Night",
"Alka-Seltzer Plus Severe Cold PowerFast Fizz Day and Night",
"Alka-Seltzer Plus Severe Cold PowerFast Fizz Day and Night",
"Alka-Seltzer Plus Severe Cold PowerFast Fizz Day and Night",
"Alka-Seltzer Plus Severe Cold PowerFast Fizz Day and Night",
"Alka-Seltzer Plus Severe Cold PowerFast Fizz Day and Night",
"Alka-Seltzer Plus Severe Cold PowerFast Fizz Day and Night",
"Alka-Seltzer Plus Severe Cold PowerFast Fizz Day and Night",
"Alka-Seltzer Plus Severe Cold Powerfast Fizz Night",
"Alka-Seltzer Plus Severe Cold PowerFast Fizz Non Drowsy",
"Alka-Seltzer Plus Severe Cold PowerFast Fizz Orange Zest",
"Alka-Seltzer Plus Severe Cold, Mucus and Congestion",
"Alka-Seltzer Plus Severe Cough and Cold Day and Night",
"Alka-Seltzer Plus Severe Cough and Cold Day and Night",
"Alka-Seltzer Plus Severe Cough Mucus and Congestion Day and Night",
"Alka-Seltzer Plus Severe Cough Mucus and Congestion Day and Night",
"Alka-Seltzer Plus Severe Cough Mucus and Congestion Liquid Gels",
"Alka-Seltzer Plus Severe Sinus and Cold",
"Alka-Seltzer Plus Severe Sinus Cold and Cough Liquid Gels",
"Alka-Seltzer Plus Severe Sinus Congestion Allergy and Cough",
"Alka-Seltzer Plus Severe Sinus Congestion and Cough",
"Alka-Seltzer Plus Severe Sinus Congestion and Cough Day and Night",
"Alka-Seltzer Plus Severe Sinus Congestion and Cough Day and Night",
"Alka-Seltzer Plus Severe Sinus Congestion and Cough Day and Night",
"Alka-Seltzer Plus Severe Sinus Congestion and Cough Day and Night",
"Alka-Seltzer Plus Severe Sinus Congestion and Cough Liquid Gels",
"Alka-Seltzer Plus Severe Sinus Congestion and Cough Liquid Gels Day",
"Alka-Seltzer Plus Severe Sinus Congestion and Cough Liquid Gels Night",
"Alka-Seltzer Plus Severe Sinus Congestion, Allergy and Cough",
"Alka-Seltzer Plus Severe Sinus Cough and Cold",
"Allerest PE",
"Allerfed",
"Allerfed",
"Allerfed Cold and Allergy",
"Allerfed Cold and Allergy",
"Allerfed Cold and Allergy",
"Allerfed Cold and Allergy PE",
"Allergie Extra Fort",
"Allergy",
"Allergy",
"Allergy + Sinus Relief Extra Strength Tablets PE",
"Allergy and Cold",
"Allergy and Cold PE",
"Allergy and Cold Relief",
"Allergy and Cough",
"Allergy and Pain Relief Multi-Symptom",
"Allergy and Sinus Headache",
"Allergy and Sinus Headache",
"Allergy and Sinus Headache",
"Allergy and Sinus Headache Relief Complete",
"allergy and sinus PE",
"Allergy and Sinus PE Maximum Strength",
"Allergy and Sinus Relief Extra Strength",
"Allergy and Stuffy Nose",
"Allergy D",
"Allergy DN PE",
"Allergy DN PE",
"Allergy Multi Symptom",
"Allergy Multi Symptom",
"Allergy Multi Symptom",
"Allergy Multi Symptom",
"Allergy Multi Symptom",
"Allergy Multi Symptom",
"Allergy Multi symptom",
"Allergy Multi Symptom",
"Allergy Multi Symptom",
"Allergy Multi Symptom",
"Allergy Multi Symptom",
"Allergy Multi Symptom",
"Allergy Multi-Symptom",
"Allergy Multi-Symptom",
"Allergy Multi-Symptom",
"Allergy Multi-Symptom",
"Allergy Multi-Symptom",
"Allergy Multi-Symptom",
"Allergy Multi-symptom",
"Allergy Multi-Symptom",
"Allergy Multi-Symptom",
"Allergy Multi-Symptom",
"Allergy Multi-Symptom",
"Allergy Multi-Symptom",
"Allergy Multi-Symptom",
"Allergy Multi-Symptom",
"Allergy Multi-Symptom",
"Allergy Multi-Symptom",
"Allergy Multi-Symptom",
"Allergy Multi-Symptom",
"Allergy Multi-Symptom",
"Allergy Multisymptom",
"Allergy Multisymptom",
"Allergy MultiSymptom",
"Allergy Pain Relief",
"Allergy Plus Cold",
"Allergy Plus Congestion",
"Allergy Plus Congestion Relief",
"Allergy Plus Severe Sinus Headache",
"Allergy Plus Sinus Headache",
"Allergy Plus Sinus Headache",
"Allergy Plus Sinus Headache",
"Allergy Plus Sinus Headache",
"Allergy Plus Sinus Headache",
"Allergy Plus Sinus Headache",
"Allergy Plus Sinus Headache",
"Allergy plus Sinus Headache",
"Allergy Plus Sinus Headache",
"Allergy Plus Sinus Relief",
"Allergy Relief",
"Allergy Relief",
"Allergy Relief",
"Allergy Relief",
"Allergy Relief",
"Allergy Relief Multi-Symptom",
"Allergy Relief Multisymptom",
"Allergy Relief Plus Congestion",
"Allergy Relief Plus Sinus Headache",
"Allergy Relief Plus Sinus Headache",
"Allergy Sinus Medication",
"allergy sinus PE",
"Allergy Sinus PE Pain Relief",
"AlleRx Dose Pack",
"AlleRx Dose Pack PE",
"AlleRx Dose Pack PE",
"Alticotron",
"Altidec A",
"Altidesp",
"Altidome DMX",
"Altilan CL",
"Altipres",
"Altipres Pediatric",
"Altipres-B",
"Always Save Mucus Relief PE",
"Anti Hemorrhoidal H Suppository",
"Antiflu",
"Antiflu Des Cough and Flu",
"Antiflu powder",
"Antigrip",
"ANTIGRIP Daytime",
"ANTIGRIP Nighttime",
"Anu-Med",
"AP-Hist DM",
"Aphedrid Cold and Allergy",
"Apj Hemorrhoidal",
"Apz Hemorrhoidal Suppositories",
"Aquanaz",
"Aramark Fedrin",
"Aramark Multi-Symptom Cold Relief",
"ASP Daytime PE",
"ASP Nighttime Max",
"Aspire Day Congestion and Headache Softgel",
"Aspire Daytime Mucus and Sinus Softgel",
"Aspire Night Cold and Flu Softgel",
"Aspirin Free Cold Head Congestion Day Time",
"Assured Childrens Cold and Cough",
"Assured Day time Cold and Cough",
"Assured Maximum Strength Mucus Relief",
"Assured Maximum Strength Nasal Decongestant",
"Assured Maximum Strength Nasal Decongestant",
"Assured Night time Cold and Cough",
"ATOPALM Hemorrhoidal",
"ATOPALM Hemorrhoidal Pain Relieving",
"Atrohist Pediatric",
"Auro Mucus - Childrens Cold, Cough and Sore Throat",
"Auro Tap Childrens Cold and Allergy",
"Auroflu Day Time Severe Cold and Cough",
"AuroFlu Day Time Severe Cold and Cough Warming Relief",
"AuroFlu Flu and Sore Throat Warming Relief",
"AuroFlu Night Time Severe Cold and Cough",
"AuroFlu Night Time Severe Cold and Cough Warming Relief",
"Auromine Childrens Cold and Allergy",
"AuroMucus - Childrens Multi-Symptom Cold",
"AuroMucus - Childrens Stuffy Nose and Cold",
"AuroMucus - Childrens Stuffy Nose and Cold",
"AuroMucus - Fast Maximum Cold and Sinus",
"AuroMucus - Fast Maximum Cold, Flu and Sore Throat Relief",
"AuroMucus - Fast Maximum Severe Congestion and Cough",
"AuroMucus - Fast Maximum Severe Congestion and Cough",
"AuroMucus Fast Maximum Night Time Cold and Flu",
"Aurophen Cold and Flu Severe",
"Aurophen Cold Multi Symptom",
"Aurophen Cold Multi Symptom",
"Aurophen Cold Multi-Symptom Severe",
"AuroQuil COLD and FLU Day Time Multi-Symptom Relief",
"AuroQuil Severe Cold and Flu Daytime Relief",
"AuroQuil Severe Cold and Flu Nighttime Relief",
"Aurotussin Peak Cold Maximum Strength Multi-Symptom Cold",
"Aurotussin Peak Cold Multi-Symptom Cold",
"Avedana Hemorrhoidal",
"Avedana HEMORRHOIDAL COOLING Gel",
"Avedana Hemorrhoidal Maximum Strength",
"Avedana Hemorrhoidal Pain Relief",
"AXIM DayTime",
"AXIM DayTime - Night Time 48 Softgels",
"AXIM DayTime - Night Time 72 Softgels",
"AXIM Sinus Severe Mucus",
"Bactimicina Cough and Cold",
"Baczol Cold Medicine",
"Baczol Cold Medicine",
"Baczol Expectorant",
"Baczol Expectorant",
"Balahist DM Syrup",
"Balamine DM Syrup",
"Basic Care Childrens Cold and Cough",
"Basic Care Childrens Cold Plus Flu",
"Basic Care Childrens Mucus Relief",
"Basic Care Day Time Cold and Flu Night Time Cold and Flu",
"Basic Care Day Time Cold and Flu Night Time Cold and Flu",
"Basic Care Day Time Night Time Cold and Flu",
"Basic Care Day Time Night Time Cold and Flu",
"Basic Care Daytime",
"Basic Care Daytime Cold and Flu",
"Basic Care Daytime Cold and Flu",
"Basic Care Daytime Cold and Flu",
"Basic Care Daytime Cold and Flu",
"Basic Care Daytime Cold and Flu",
"Basic Care Daytime Cold and Flu Nighttime Cold and Flu",
"Basic Care Daytime Cold and Flu Severe",
"Basic Care Daytime Nighttime Cold and Flu",
"Basic Care Daytime Nighttime Cold and Flu",
"Basic Care Daytime Nighttime Cold and Flu",
"Basic Care Daytime Nighttime Cold and Flu",
"Basic Care Daytime Nighttime Cold and Flu",
"Basic Care Daytime Nighttime Cold and Flu",
"Basic Care Daytime Nighttime Severe Cold and Flu",
"Basic Care Daytime Nighttime Severe Cold and Flu",
"Basic Care daytime nighttime severe cold and flu",
"Basic Care daytime nighttime severe cold and flu",
"Basic Care Daytime Nighttime Severe Cold and Flu",
"Basic Care Daytime Nighttime Severe Cold and Flu",
"Basic Care Daytime Nighttime Severe Cold and Flu",
"Basic Care Daytime Nighttime Severe Cold and Flu",
"Basic Care Daytime Nighttime Severe Cold and Flu",
"Basic Care Daytime Nighttime Severe Cold and Flu",
"Basic Care Daytime Severe Cold and Flu",
"Basic Care Daytime Severe Cold and Flu",
"Basic Care Daytime Severe Cold and Flu",
"Basic Care Daytime Severe Cold and Flu",
"Basic Care Daytime Severe Cold and Flu Nighttime Cold and Flu",
"Basic Care Daytime Severe Cold and Flu Nighttime Cold and Flu",
"Basic Care Daytime Severe Cold and Flu Nighttime Severe Cold and Flu",
"Basic Care Daytime Severe Cold and Flu Nighttime Severe Cold and Flu",
"Basic Care Daytime Severe Cold and Flu Nighttime Severe Cold and Flu",
"Basic Care Daytime Severe Cold and Flu Nighttime Severe Cold and Flu",
"Basic Care Daytime Severe Cold and Flu Nighttime Severe Cold and Flu",
"Basic Care Daytime Severe Cold and Flu Nighttime Severe Cold and Flu",
"Basic Care Daytime Severe Cold and Flu Nighttime Severe Cold Cough and Flu",
"Basic Care Daytime Severe Cold and Flu Nighttime Severe Cold Cough and Flu",
"Basic Care Daytime Severe Cold and Flu Nighttime Severe Cold, Cough and Flu",
"Basic Care Daytime Severe Cold and Flu Nighttime Severe Cold, Cough and Flu",
"Basic Care Daytime Severe Cold Nighttime Cold and Flu",
"Basic Care Daytime Severe Cold Nighttime Cold and Flu",
"Basic Care Daytime Severe Cold Nighttime Cold and Flu",
"Basic Care Daytime Severe Cold Nighttime Cold and Flu",
"Basic Care Hemorrhoidal",
"Basic Care Hemorrhoidal",
"Basic Care Hemorrhoidal",
"Basic Care Mucus Relief Cold Flu and Sore Throat",
"Basic Care Mucus Relief Severe Congestion and Cough",
"Basic Care Nasal",
"Basic Care Nighttime Cold and Flu",
"Basic Care Nighttime Cold and Flu Severe",
"Basic Care Nighttime Severe Cold and Flu",
"Basic Care Nighttime Severe Cold and Flu",
"Basic Care Nighttime Severe Cold and Flu",
"Basic Care Nighttime Severe Cold and Flu",
"Basic Care Nighttime Severe Cold and Flu",
"Basic Care severe cold and cough",
"Basic Care Severe Cold and Flu",
"Basic Care Severe Cold and Flu",
"Basic Care Sinus PE",
"Basic Care Sinus PE",
"Basic Care Sinus Plus Headahce",
"Basic Care Tussin CF Severe",
"Basic Care Tussin CF Severe",
"BC Daytime Multi-Symptom",
"BC Sinus Congestion and Pain",
"BC Sinus Congestion and Pain",
"Benadryl Allergy & Sinus",
"Benadryl Allergy Plus Cold",
"Benadryl Allergy Plus Congestion",
"Benadryl Allergy Rapid Release",
"Benadryl Allergy Sinus Headache",
"Benadryl PE Total Extra Strength",
"Benadryl PE Total Regular Strength",
"Benadryl-D Allergy and Sinus",
"Benylin All-IN-one Cold & Flu Daytime",
"Benylin All-IN-one Cold & Flu Nighttime",
"Benylin All-IN-one Cold and Flu Night PE Caplets",
"Benylin All-IN-one Cold and Flu PE Caplets",
"Benylin Cold and Sinus Night Caplets",
"Benylin Cold Strips",
"Benylin D for Infants",
"Benylin DM-D",
"Benylin DM-D for Children",
"Benylin DM-D for Infants",
"Benylin DM-D Soft Chews With Menthactin",
"Benylin DM-D-E",
"Benylin Extra Strength All-IN-one Cold and Flu",
"Benylin Extra Strength All-IN-one Cold and Flu Nightime",
"Benylin Extra Strength Cold & Sinus Day",
"Benylin Extra Strength Cold & Sinus Night",
"Benylin Extra Strength Cold & Sinus Plus",
"Benylin Extra Strength With Menthactin",
"Berkley and Jensen Nasal Decongestant PE Non-Drowsy Maximum Strength",
"Best Choice Daytime Severe Cold and Cough Berry infused with Menthol and Green Tea flavors",
"Best Choice Effervescent Cold Relief",
"Best Choice Nighttime Severe Cold and Cough Honey Lemon infused with Chamomile and White Tea Flavors",
"Betr Cold and Flu Daytime Relief",
"Betr Cold and Flu Nighttime Relief",
"Better Living",
"Bio T Pres-B",
"Bio-B Kids",
"Bio-G-Tuss Pediatric Drops",
"Bio-rytuss",
"Bio-S-Pres DX",
"Biobron DX",
"Biobron SF",
"Biocof",
"Biocotron PED",
"Biocotron-D",
"Biodesp DM",
"Biodesp DM NF",
"BioGtuss",
"BioGtuss NF",
"Biogtuss TR",
"Biohisdex DM Decongestant",
"Biohisdine DM Decongestant",
"Bionatuss DXP",
"Biophex TR",
"Biorphen",
"Biorphen",
"Biorphen",
"Biorphen",
"Biorphen",
"BioTPres",
"BioTPres Pediatric",
"Bliss GVS Hemorrhoidal",
"Bliss Gvs Hemorrhoidal",
"BPM Mal Phenyleph HCl DM HBr",
"Bpm-DM-phen",
"BranTussin DM",
"Brohist D",
"Brom Mal Phenyl HCl Dex HBr",
"Brom Tapp",
"Brom Tapp DM",
"Bromhist PDX",
"Brompheniramine Phenylephrine DM",
"Bronco-Flu Plus",
"Broncochem Allergy Control",
"Broncochem Cold and Flu Caplets",
"Broncochem Expectorant II",
"Broncochem Kids Cold and Flu",
"Broncofin",
"Broncolin Cold and Flu Relief",
"Broncomar",
"Broncomar EXPECTORANT",
"Broncotron D",
"Broncotron PED",
"Broncotron PED",
"Bronkids",
"Bronkids",
"Bronkids",
"Brontuss DX",
"Brontuss SF",
"Brontuss SF-NR",
"Brotapp PE Liquid",
"Brotapp PE-DM Cough and Cold",
"BroveX PEB",
"BroveX PEB DM",
"Bubbles R Better Effervescent Cold Relief",
"Buckley's Complete Cough, Cold & Flu Day",
"Buckley's Complete Cough, Cold & Flu Night",
"Buckley's Complete Relief",
"Buckley's Complete Relief",
"Buckley's Complete Relief + Mucus",
"Buckley's Complete Relief + Mucus",
"Budpak Hemorrhoid Anesthetic",
"C-Tanna 12D Suspension",
"Cabinet Nasal Decongestant",
"Calmadol Plus",
"CapCof",
"Carbaphen CH",
"Carbaphen Ped CH",
"Carbatuss",
"Carbetaplex",
"Cardec",
"Cardec DM",
"Care One Cold and Allergy",
"Care One Cold Head Congestion",
"Care One Cold Head Congestion",
"Care One Cold Head Congestion",
"Care One cold head congestion",
"Care One Cold Head Congestion daytime non-drowsy",
"Care One Cold Multi Symptom",
"Care One Cold Multi Symptom",
"Care One Cold Multi Symptom",
"Care One Cold Multi Symptom",
"Care One Cold Mutli Symptom",
"Care One Flu and Severe Cold and Cough Daytime",
"Care One Flu and Severe Cold and Cough Nighttime",
"Care One Flu and Severe Cold Daytime",
"Care One Flu and Sore Throat",
"Care One Hemorrhoidal",
"Care One Hemorrhoidal",
"Care One Nasal Decongestant PE Maximum Strength Non Drowsy",
"Care One Nasal Four",
"Care One Nose Drops",
"Care One Sinus",
"Care One Sinus",
"Care One Sinus and Allergy PE",
"Care One Sinus Congestion and Pain",
"CAREALL Hemorrhoidal",
"CareOne Adult Tussin CF",
"Careone Allergy and Cough Severe Sinus Congestion",
"CareOne Childrens Cold and Allergy",
"CareOne Childrens Cold and Cough",
"CareOne Childrens Cold and Flu",
"CareOne Childrens Mucus Relief",
"Careone Childrens Multi Symptom Fever and Cold",
"CareOne Cold and Sinus",
"CareOne Cold and Sinus",
"CareOne Cold and Sinus",
"CareOne Cold Flu and sore throat",
"Careone Cold Max",
"CareOne Cold plus Flu Severe",
"Careone Day Cold and Flu Night Cold and Flu",
"Careone Day Cold and Flu Night Cold and Flu",
"Careone Day Severe Cold Night Cold and Flu",
"Careone Day Severe Cold Night Cold and Flu",
"CareOne Day Time Severe Cold Night Time Cold and Flu",
"CareOne Day Time Severe Cold Night Time Cold and Flu",
"CareOne DayTime Cold and Flu",
"CareOne Daytime Cold Flu Relief",
"CareOne Daytime Nighttime Cold and Flu",
"CareOne Daytime Nighttime Cold Flu Relief",
"Careone Daytime Nighttime Severe Cold and Flu",
"Careone Daytime Nighttime Severe Cold and Flu",
"Careone Daytime Severe Cold and Cough",
"CareOne Daytime Severe Cold and Cough Berry infused with Menthol and Green Tea flavors",
"Careone daytime severe cold and flu",
"Careone Daytime Severe Cold Flu Relief",
"CareOne Fast Acting Nasal",
"Careone Hemorrhoidal",
"CareOne Hemorrhoidal",
"Careone Hemorrhoidal",
"CareOne Hemorrhoidal",
"CareOne Mucus Relief",
"CareOne Mucus Relief",
"CareOne Mucus Relief Cold and Sinus",
"CareOne Mucus Relief Severe Congestion and Cold",
"Careone night time severe cold and cough honey lemon infused with chamomile and white tea flavors",
"CareOne Nighttime Severe Cold and Cough",
"CareOne Nighttime Severe Cold and Flu",
"CareOne Nitetime Severe Cold Flu Relief",
"CareOne Severe Cold",
"Careone Severe Sinus Congestion",
"Careone Severe Sinus Congestion and Pain",
"CareOne Sinus plus Headache",
"CareOne Sinus Plus Headache",
"CareOne Sinus Plus Headache",
"Careone Sinus Relief Day Time Night Time",
"Careone Sinus Relief Day Time Night Time",
"CareOne sinus relief day time sinus relief night time",
"CareOne sinus relief day time sinus relief night time",
"CareOne Sinus Relief Severe",
"Careone Sinus Sever Congestion Relief",
"CareOne Triacting Night Time Cold and Cough Childrens",
"CareOne Tussin CF Multi Symptom Cold",
"Caring Mill Childrens Cold and Cough",
"Caring Mill Childrens Mucus Relief",
"Caring Mill Daytime",
"Caring Mill Daytime Cold and Flu",
"Caring Mill Nasal Four",
"caring mill Sinus PE",
"Centussin Dhc",
"Ceron",
"Ceron DM",
"Certi-sine",
"Cetafen Cough and Cold",
"CETAFEN COUGH and COLD",
"Children's Benadryl-D Syrup",
"Children's Coltalin Fruit Flavor Chewable Cold Tablets",
"Children's Tylenol Cold",
"Children's Tylenol Cold",
"Children's Tylenol Cold and Cough",
"Children's Tylenol Cold and Cough",
"Children's Tylenol Decongestant",
"Childrens Allergy Plus Congestion",
"Childrens Allergy Plus Congestion",
"Childrens Allergy Plus Congestion",
"Childrens Allergy Plus Congestion Relief",
"Childrens Aurotussin Cough and Cold CF",
"Childrens Benadryl Allergy Plus Congestion",
"Childrens Benadryl-D ALLERGY and SINUS",
"Childrens Cold and Allergy",
"Childrens Cold and Allergy",
"Childrens Cold and Allergy",
"Childrens Cold and Allergy",
"Childrens Cold and Allergy",
"Childrens Cold and Allergy",
"Childrens Cold and Allergy",
"Childrens Cold and Allergy",
"Childrens Cold and Allergy",
"Childrens Cold and Allergy",
"Childrens Cold and Allergy Relief",
"Childrens Cold and Allergy Relief",
"Childrens Cold and Allergy Relief",
"Childrens Cold and Allergy Relief",
"Childrens Cold and Cough",
"Childrens Cold and Cough",
"Childrens Cold and Cough",
"Childrens Cold and Cough",
"Childrens Cold and Cough",
"Childrens Cold and Cough",
"Childrens Cold and Cough Nighttime",
"Childrens Cold and Cough Nighttime",
"Childrens Cold and Cough Nighttime",
"Childrens Cold and Cough Relief",
"Childrens Cold and Flu",
"Childrens Cold, Cough and Sore Throat",
"Childrens Cold, Cough and Sore Throat",
"Childrens Coltalin",
"Childrens Cough and Cold",
"Childrens Cough and Cold CF",
"Childrens Cough and Cold CF",
"Childrens Cough and Cold Nighttime",
"Childrens Day Time Cold and Cough",
"Childrens Daytime Cold and Cough",
"Childrens Daytime Cold and Cough",
"Childrens Daytime Cold and Cough",
"Childrens Delsym Cough Plus Chest Congestion DM and Delsym Cough Plus Cold Night Time",
"Childrens Delsym Cough Plus Cold Day Time",
"Childrens Delsym Cough Plus Cold Night Time",
"Childrens Dibromm Cold and Allergy",
"Childrens Dibromm Cold and Allergy",
"Childrens Dibromm Cold and Allergy",
"Childrens Dibromm Cold and Allergy",
"Childrens Dibromm Cold and Cough",
"Childrens Dibromm Cold and Cough",
"Childrens Dimetapp Cold and Allergy",
"Childrens Dimetapp Cold and Allergy",
"Childrens Dimetapp Cold and Cough",
"Childrens Dimetapp Cold and Cough",
"Childrens Dimetapp Cold and Cough",
"Childrens Dimetapp Multi-Symptom Cold and Flu",
"Childrens Dimetapp Multi-Symptom Cold Relief Dye-Free",
"Childrens Dimetapp Multisymptom Cold and Flu",
"Childrens Dimetapp Nighttime Cold and Congestion",
"Childrens Flu Relief",
"Childrens Metapp Daytime",
"Childrens Mucinex Cold, Cough and Sore Throat",
"Childrens Mucinex Congestion and Cough",
"Childrens Mucinex Congestion and Cough",
"Childrens Mucinex Multi Symptom Cold and Childrens Mucinex Night Time Multi Symptom Cold",
"Childrens Mucinex Multi Symptom Cold and Childrens Mucinex Night Time Multi Symptom Cold",
"Childrens Mucinex Multi-Symptom Cold",
"Childrens Mucinex Multi-Symptom Cold",
"Childrens Mucinex Multi-Symptom Cold and Fever",
"Childrens Mucinex Night Time Multi-Symptom Cold",
"Childrens Mucinex Stuffy Nose and Cold",
"Childrens Mucinex Stuffy Nose and Cold",
"Childrens Mucus Cough and Congestion Relief",
"Childrens mucus relief",
"Childrens Mucus Relief",
"Childrens Mucus Relief Cough, Cold and Sore Throat",
"Childrens Mucus Relief Multi Symptom Cold",
"Childrens Mucus Relief Multi Symptom Cold",
"Childrens mucus relief multi-symptom cold",
"Childrens Multi Symptom Cold",
"Childrens Multi Symptom Cold",
"Childrens Multi Symptom Cold",
"childrens Multi Symptom Fever and Cold",
"Childrens Multi Symptom Fever and Cold",
"Childrens Multi Symptom Fever and Cold",
"Childrens Multi-Symptom Cold",
"Childrens Multi-symptom Cold",
"Childrens Multi-symptom Cold",
"Childrens Multi-symptom Cold and Fever Liquid",
"Childrens Multi-Symptom Cold and Fever Relief",
"Childrens Multi-Symptom Cold Plus Dye-Free",
"Childrens Night Time Cold and Cough",
"Childrens Night Time Cold and Cough",
"Childrens Night Time COUGH and COLD RELIEF",
"Childrens Nighttime Cold and Cough",
"Childrens Nighttime Cold and Cough",
"Childrens Nighttime Cold and Cough",
"Childrens Pain Relief Cold and Flu",
"Childrens Pain Relief Plus Multi Symptom Cold",
"Childrens Plus Cold",
"Childrens Plus Cold",
"Childrens Plus Cold Grape",
"Childrens Plus Cold Grape",
"Childrens Plus Flu",
"Childrens Plus Flu",
"Childrens Plus Flu",
"Childrens Plus Flu with PE",
"Childrens Plus Multi Symptom Cold",
"Childrens Plus Multi Symptom Cold",
"Childrens Plus Multi Symptom Cold",
"Childrens Plus Multi Symptom Cold",
"Childrens Plus Multi Symptom Cold",
"Childrens Plus Multi Symptom Cold",
"Childrens Plus Multi Symptom Cold",
"Childrens Plus Multi Symptom Cold",
"Childrens Plus Multi Symptom Cold",
"Childrens Plus Multi Symptom Cold Dye Free",
"Childrens Plus Multi Symptom Cold DYE FREE",
"Childrens Plus Multi-Symptom Cold Grape with PE",
"Childrens Plus Multi-Symptom Cold Grape with PE",
"Childrens Plus Multi-Symptom Cold Grape with PE",
"Childrens Plus Multi-Symptom Cold Grape with PE",
"Childrens Plus Multi-Symptom Cold Grape with PE",
"Childrens Plus Multi-Symptom Grape with PE",
"Childrens Plus Multi-Symptom with PE",
"Childrens Robitussin Cough and Cold CF",
"Childrens Stuffy Nose and Cold",
"Childrens SUDAFED PE Cold plus Cough",
"Childrens Sudafed PE NASAL DECONGESTANT",
"Childrens Triacting",
"Childrens Triacting",
"Childrens Triacting Night Time Cold and Cough",
"Childrens Triacting Nighttime Cold and Cough",
"Childrens Triacting Nighttime Cold and Cough",
"Childrens Triacting Nighttime Cold and Cough ReadyInCase",
"Childrens Tukol Multi-Symptom Cold and Flu",
"Childrens Tussnex",
"Childrens Tussnex Multi-symptom cold",
"Childrens TYLENOL COLD Plus FLU",
"Childrens TYLENOL COLD Plus FLU",
"Childrens Tylenol Plus Cold and Allergy",
"Childrens Tylenol Plus Flu",
"Childrens Tylenol Plus Multi-Symptom Cold",
"Childrens Tylenol Plus Multi-Symptom Cold",
"Childrens Wal Dryl PE",
"Childrens Wal Tap DM",
"Childrens Wal Tap DM Cough and Cold",
"Childrens Wal Tap Elixer Cold and Allergy",
"Chlo Tuss",
"Chlor-Tan A 12 Suspension",
"Chloresin",
"Chlorpheniramine Maleate, Phenylephrine Hydrochloride",
"Chlorpheniramine Maleate, Phenylephrine Hydrochloride",
"Chlorphenylcaine",
"Circle K Cold",
"Circle K Cold",
"Circle K Daytime Cold and Flu",
"Circle K Daytime Cold and Flu",
"Circle K Daytime Cold and Flu",
"Circle K Daytime Cold and Flu",
"Circle K Daytime Cold and Flu",
"Circle K Daytime Cold and Flu",
"Circle K Daytime Cold and Flu",
"Circle K Daytime Cold and Flu",
"Circle K Daytime Cold and Flu",
"Circle K Daytime Cold and Flu",
"Circle K Daytime Cold and Flu",
"Circle K Multi-Symptom Sinus Relief",
"Citron Chaud Cumberland Pws",
"Citron Chaud DM Cumberland Pws",
"Citron Chaud DM Option + Pws",
"Citron Chaud Extra Fort",
"Citron Chaud Réguliern DM",
"Clear Eyes Pure Relief Multisymptom",
"Clear Eyes Sensitive",
"Cleartime",
"ClearTime",
"Clophed",
"Cocoa Butter, Phenylephrine Hydrochloride",
"Cocoa Butter, Phenylephrine Hydrochloride",
"Cocoa Butter, Phenylephrine Hydrochloride, Shark Liver Oil",
"Codituss DM",
"Cold",
"Cold",
"Cold",
"Cold",
"Cold",
"Cold",
"Cold",
"Cold & Allergy Relief - Liq",
"Cold & Flu",
"Cold & Flu Super Strength",
"Cold & Stuffy Nose",
"Cold Allergy",
"Cold and Allergy",
"Cold and Allergy",
"Cold and Allergy",
"Cold and Allergy",
"Cold and Allergy",
"Cold and Allergy",
"Cold and Allergy",
"Cold and Allergy",
"Cold and Allergy",
"Cold and Allergy",
"Cold and Allergy",
"Cold and Allergy",
"Cold and Allergy",
"Cold and Allergy",
"Cold and Allergy Childrens",
"Cold and Allergy Childrens",
"Cold and Allergy childrens",
"Cold and Allergy Childrens",
"Cold and Allergy Maximum Strength",
"Cold and Allergy Maximum Strength",
"Cold and Allergy Maximum strength",
"Cold and Allergy PE",
"Cold and Allergy PE",
"Cold and Allergy Relief",
"Cold and Allergy Relief",
"Cold and Allergy Relief",
"Cold and Allergy Relief",
"Cold and Chest Congestion Relief",
"Cold and Chest Congestion Relief",
"Cold and Congestion Childrens Nighttime",
"Cold and Cough",
"Cold and Cough",
"Cold and Cough",
"Cold and Cough",
"Cold and Cough",
"Cold and Cough",
"Cold and Cough childrens",
"Cold and Cough Childrens",
"Cold and Cough Childrens",
"Cold and Cough Childrens",
"Cold and Cough Day Time Childrens",
"Cold and Cough DM",
"Cold and Cough MULTI-SYMPTOM DAYTIME / NIGHTTIME",
"Cold and Cough MULTI-SYMPTOM DAYTIME / NIGHTTIME",
"Cold and Cough PE",
"Cold and Cough Relief children",
"cold and cough sinus relief PE NON-DROWSY",
"Cold and Flu",
"Cold and Flu",
"Cold and Flu",
"Cold and Flu",
"COLD and FLU",
"COLD and FLU",
"Cold and Flu",
"Cold and Flu",
"Cold and Flu",
"Cold and Flu",
"Cold and Flu",
"Cold and Flu All In One",
"Cold and Flu Day",
"Cold and Flu Day and Night, Severe",
"Cold and Flu Day and Night, Severe",
"Cold and Flu Day Night",
"Cold and Flu Day Time Multi-Symptom Relief",
"COLD and FLU Day Time Multi-Symptom Relief",
"COLD and FLU Day Time Multi-Symptom Relief",
"Cold and Flu Day, Night",
"Cold and Flu Daytime",
"Cold and Flu Daytime",
"Cold and Flu DayTime",
"Cold and Flu DayTime",
"Cold and Flu DayTime",
"Cold and Flu Daytime",
"Cold and Flu Daytime",
"Cold and Flu DayTime",
"Cold and Flu daytime",
"Cold and Flu Daytime",
"Cold and Flu Daytime",
"Cold and Flu Daytime",
"Cold and Flu Daytime",
"Cold and Flu Daytime",
"Cold and Flu Daytime",
"Cold and Flu Daytime",
"COLD and FLU DAYTIME MAXIMUM STRENGTH NON-DROWSY SEVERE",
"COLD and FLU DAYTIME MAXIMUM STRENGTH NON-DROWSY SEVERE",
"COLD and FLU DAYTIME MAXIMUM STRENGTH NON-DROWSY SEVERE",
"Cold and Flu Daytime Nighttime",
"Cold and Flu Daytime Nighttime",
"Cold and Flu Daytime Nighttime",
"Cold and Flu Daytime Nighttime",
"Cold and Flu Daytime Relief",
"Cold and Flu Daytime Relief",
"Cold and Flu Daytime Relief",
"Cold and Flu DayTime Relief",
"Cold and Flu Daytime Severe",
"Cold and Flu Daytime Severe",
"Cold and Flu Daytime Severe",
"Cold and Flu Daytime Severe, 24/7 Life",
"Cold and Flu Daytime Severe, Nighttime Severe",
"Cold and Flu Daytime Severe, Nighttime Severe",
"Cold and Flu Daytime-nighttime",
"Cold and Flu Daytime-nighttime",
"Cold and Flu Daytime, Nighttime",
"Cold and Flu Daytime, Nighttime",
"Cold and Flu Daytime, Nighttime",
"Cold and Flu Daytime, Nighttime",
"Cold and Flu DayTime, NightTime Severe",
"Cold and Flu DayTime, NightTime Severe",
"Cold and Flu Daytime, Nighttime, Maximum Strength",
"Cold and Flu Daytime, Nighttime, Maximum Strength",
"Cold and Flu Daytime, Nighttime, Multi-Symptom",
"Cold and Flu Daytime, Nighttime, Multi-Symptom",
"Cold and Flu Daytime, Nighttime, Multi-Symptom",
"Cold and Flu Daytime, Nighttime, Multi-Symptom",
"Cold and Flu Daytime, Nighttime, Multi-Symptom",
"Cold and Flu Daytime, Nighttime, Multi-Symptom",
"Cold and Flu Daytime, Nighttime, Multi-Symptom",
"Cold and Flu Daytime/Multi-Symptom/Non-Drowsy",
"Cold and Flu Daytime/Nightime",
"Cold and Flu Daytime/Nightime",
"Cold and Flu Daytime/Nighttime",
"Cold and Flu maximum strength",
"Cold and Flu Multi-Symptom Daytime Nighttime",
"Cold and Flu Multi-Symptom Daytime/Nighttime Severe",
"Cold and Flu Multi-Symptom Daytime/Nighttime Severe",
"Cold and Flu Multi-Symptom Nighttime Severe",
"Cold and Flu Multi-symptom Relief/cold and Flu Nighttime Relief",
"Cold and Flu Multi-symptom Relief/cold and Flu Nighttime Relief",
"Cold and Flu Night",
"Cold and Flu Nighttime",
"Cold and Flu Nighttime",
"Cold and Flu Nighttime",
"Cold and Flu Nighttime Severe",
"Cold and Flu Nighttime Severe",
"Cold and Flu Nighttime Severe",
"Cold and Flu Nighttime Severe, 24-7 Life",
"Cold and Flu Non Drowsy Day Relief and Night Relief",
"Cold and Flu Non Drowsy Daytime and Nighttime",
"Cold and Flu Non Drowsy Daytime and Nighttime",
"Cold and Flu Non Drowsy Daytime and Nighttime",
"Cold and Flu Non-Drowsy, DayTime",
"Cold and Flu Non-Drowsy, Daytime",
"Cold and Flu Plus",
"Cold and Flu Plus",
"Cold and Flu plus Congestion Daytime",
"Cold and Flu plus Congestion Nighttime",
"Cold and Flu Relief",
"Cold and Flu Relief",
"Cold and Flu Relief",
"Cold and Flu Relief",
"Cold and Flu Relief",
"Cold and Flu Relief",
"Cold and Flu Relief",
"Cold and Flu Relief",
"Cold and Flu Relief",
"Cold and Flu Relief Daytime",
"Cold and Flu Relief Daytime",
"Cold and Flu Relief DayTime",
"Cold and Flu Relief Daytime",
"Cold and Flu Relief Daytime",
"Cold and Flu Relief Daytime",
"Cold and Flu Relief Daytime",
"Cold and Flu Relief Daytime",
"Cold and Flu Relief Daytime",
"Cold and Flu Relief Daytime",
"Cold and Flu Relief Daytime Multi Symptom",
"Cold and Flu Relief Daytime Nighttime",
"Cold and Flu Relief Daytime Non Drowsy",
"Cold and Flu Relief Daytime, Multi-Symptom",
"Cold and Flu Relief Daytime, Nighttime",
"Cold and Flu Relief Daytime/Nighttime",
"Cold and Flu Relief Daytime/Nighttime",
"Cold and Flu Relief Multi symptom",
"Cold and Flu Relief Multi symptom",
"Cold and Flu Relief Multi symptom",
"Cold and Flu Relief Multi symptom",
"Cold and Flu Relief Multi symptom",
"Cold and Flu Relief Multi-Symptom",
"Cold and Flu Relief Multi-Symptom",
"Cold and Flu Relief Multi-Symptom, Day, Night",
"Cold and Flu Relief Multi-Symptom, DayTime",
"Cold and Flu Relief Multi-Symptom, DayTime",
"Cold and Flu Relief Non-Drowsy / Daytime Severe / Nighttime Severe",
"Cold and Flu Relief Non-Drowsy / Daytime Severe / Nighttime Severe",
"Cold and Flu Relief Non-Drowsy, DayTime, Multi-Symptom",
"Cold and Flu Relief Severe",
"Cold and Flu Relief Severe",
"Cold and Flu Relief Severe Daytime",
"Cold and Flu Severe",
"Cold and Flu Severe",
"Cold and Flu Severe",
"Cold and Flu Severe",
"Cold and Flu severe",
"Cold and Flu Severe",
"Cold and Flu Severe",
"Cold and Flu Severe",
"Cold and Flu Severe",
"Cold and Flu Severe",
"Cold and Flu Severe",
"Cold and Flu Severe",
"Cold and Flu Severe",
"COLD and FLU SEVERE",
"Cold and Flu Severe",
"Cold and Flu Severe",
"Cold and Flu Severe",
"Cold and Flu Severe",
"Cold and Flu Severe",
"Cold and Flu Severe Day Time / Night Time",
"Cold and Flu Severe Day Time / Night Time",
"Cold and Flu Severe Daytime",
"Cold and Flu Severe Daytime",
"Cold and Flu Severe Daytime and Nighttime",
"Cold and Flu Severe Daytime and Nighttime",
"Cold and Flu Severe Daytime Nighttime",
"Cold and Flu Severe Daytime Nighttime",
"Cold and Flu Severe Daytime/Nighttime",
"Cold and Flu Severe Daytime/Nighttime",
"Cold and Flu Severe Night",
"Cold and Flu Severe Nighttime",
"Cold and Flu Severe, Day and Nighttime",
"Cold and Flu Severe, Day and Nighttime",
"Cold and Flu Severe, Day, Night",
"Cold and Flu Severe, Day, Night",
"Cold and Flu Severe, Daytime, Nighttime",
"Cold and Flu Severe, Daytime, Nighttime",
"Cold and Flu Severe, Nighttime, Maximum Strength",
"Cold and Head Congestion Relief Severe",
"Cold and Head Congestion Severe",
"Cold and Head Congestion Severe",
"Cold and Head Congestion Severe",
"Cold and Head Congestion Severe",
"Cold and Head Congestion Severe/Daytime",
"Cold and Sinus",
"Cold and Sinus Maximum Strength",
"Cold and Sinus Maximum Strength, Multi-Symptom",
"Cold and Sinus Maxium Strength",
"Cold and Sinus Pain Relief",
"cold and sinus PE",
"Cold and Sinus PE Pressure, Pain and Cold Non-Drowsy",
"Cold and Sore Throat",
"Cold Chest Congestion PE Regular Strength",
"Cold Childrens, Multi Symptom",
"Cold Daytime",
"Cold DayTime, Multi-Symptom, Non-drowsy",
"Cold FAid",
"Cold FAid",
"Cold FAid",
"Cold Flu and Sore Throat",
"Cold Flu and Sore Throat",
"Cold Flu and Sore Throat",
"Cold Flu and Sore Throat",
"Cold Flu and Sore Throat",
"Cold Flu and Sore Throat Maximum Strength",
"Cold Flu and Sore Throat Maximum Strength",
"Cold Flu and Sore Throat Maximum Strength",
"COLD FLU and SORE THROAT RELIEF",
"COLD FLU and SORE THROAT RELIEF",
"COLD FLU and SORE THROAT RELIEF",
"COLD FLU and SORE THROAT RELIEF",
"COLD FLU and SORE THROAT RELIEF",
"COLD FLU and SORE THROAT RELIEF",
"Cold Flu and Sore Throat Relief Maximum Strength",
"Cold Flu Relief Daytime",
"Cold Flu Severe",
"Cold Flu Severe",
"Cold Flu Severe",
"Cold Flu Severe",
"Cold Flu Severe",
"Cold Flu Severe",
"Cold Flu Severe Day Night",
"Cold Flu Severe Day Night",
"Cold Flu Severe Day Night",
"Cold Flu Severe Day Night",
"Cold Flu Sore Throat",
"Cold Formula Daytime Nighttime, Non-Aspirin, Multi-Symptom",
"Cold Formula Daytime Nighttime, Non-Aspirin, Multi-Symptom",
"Cold Head Congestion",
"Cold Head Congestion",
"Cold Head Congestion",
"Cold Head Congestion",
"Cold Head Congestion Daytime",
"Cold Head Congestion Daytime",
"Cold Head Congestion Daytime / Nighttime",
"Cold Head Congestion Daytime / Nighttime",
"Cold Head Congestion Daytime Non-Drowsy",
"Cold Head Congestion Night Time",
"Cold Head Congestion Nighttime",
"Cold Head Congestion Nighttime",
"Cold Head Congestion Nighttime",
"Cold Head Congestion Non-Drowsy",
"Cold Head Congestion Severe",
"Cold Head Congestion Severe",
"Cold Head Congestion Severe",
"Cold Head Congestion Severe",
"Cold Head Congestion Severe",
"Cold Head Congestion Severe",
"Cold Liquid",
"Cold Liquid",
"Cold Liquid Grape Flavour",
"Cold Max",
"Cold Max",
"Cold Max",
"Cold Max",
"Cold Max",
"Cold Max",
"Cold Max",
"Cold Max Day and Night",
"Cold Max Day and Night",
"Cold Max Daytime",
"Cold Max Multi Symptom",
"Cold Max Multi Symptom Nighttime",
"Cold Max Multi Symptom Severe",
"Cold Max Nighttime",
"Cold Max Nighttime",
"Cold Max Nighttime",
"Cold Max Nighttime",
"Cold Max Severe",
"Cold Medication Daytime Relief",
"Cold Medication Regular Nighttime Tablets PE",
"Cold Medicine",
"Cold Medicine",
"Cold Medicine XL-3 for Children",
"Cold Medicine XL3",
"Cold Medicine XL3",
"Cold Medicine XL3",
"Cold Medicine XL3 FORTE",
"Cold Medicine XL3 FORTE",
"Cold Medicine XL3 FORTE",
"Cold Multi Symptom",
"Cold Multi Symptom",
"Cold Multi Symptom",
"Cold Multi Symptom",
"Cold Multi Symptom Daytime Nighttime",
"Cold Multi Symptom Daytime Nighttime",
"Cold Multi Symptom Nighttime",
"Cold Multi Symptom Relief",
"Cold Multi Symptom Relief",
"Cold Multi Symptom Severe",
"Cold Multi-Symptom",
"Cold Multi-Symptom",
"Cold Multi-Symptom",
"Cold Multi-Symptom",
"Cold Multi-Symptom",
"Cold Multi-Symptom",
"Cold Multi-Symptom",
"Cold Multi-Symptom",
"Cold Multi-Symptom",
"Cold Multi-Symptom",
"Cold Multi-Symptom Day-time",
"Cold Multi-Symptom Daytime",
"Cold Multi-Symptom Daytime",
"Cold Multi-Symptom Daytime and Nighttime",
"Cold Multi-Symptom Daytime and Nighttime",
"Cold Multi-Symptom Daytime Nighttime",
"Cold Multi-Symptom Daytime Nighttime",
"Cold Multi-Symptom Daytime Non-Drowsy",
"Cold Multi-Symptom Night-time",
"Cold Multi-Symptom Nighttime",
"Cold Multi-Symptom Nighttime",
"Cold Multi-Symptom Nighttime",
"Cold Multi-Symptom Non-Drowsy, Daytime",
"Cold Multi-Symptom Severe",
"Cold Multi-Symptom Severe",
"Cold Multi-Symptom Severe",
"Cold Multi-Symptom Severe Day Time",
"Cold Multi-Symptom, Daytime",
"Cold MULTI-SYMPTOM, DAYTIME / NIGHTTIME",
"Cold MULTI-SYMPTOM, DAYTIME / NIGHTTIME",
"Cold Pain Relief",
"Cold PE",
"Cold plus Flu Severe",
"Cold plus Flu Severe",
"Cold plus Head Congestion",
"Cold Plus Head Congestion Day and Night",
"Cold Plus Head Congestion Day and Night",
"Cold Plus Head Congestion Daytime",
"Cold Plus Head Congestion Nighttime",
"Cold Plus Head Congestion Severe",
"Cold plus Head Congestion Severe",
"Cold Preparation",
"Cold Preparation For Cough and Sinus Relief",
"Cold relief",
"Cold Relief",
"Cold Relief",
"Cold Relief",
"Cold Relief",
"Cold Relief",
"Cold Relief",
"Cold Relief",
"Cold Relief",
"Cold Relief",
"Cold Relief",
"Cold Relief",
"Cold Relief",
"Cold Relief",
"Cold Relief",
"Cold Relief",
"Cold Relief",
"Cold Relief Cold and Flu Severe",
"Cold Relief Daytime",
"Cold Relief Daytime",
"Cold Relief Head Congestion",
"Cold Relief Head Congestion",
"Cold Relief Head Congestion Daytime Non-Drowsy",
"Cold Relief Head Congestion Severe",
"Cold Relief Maximum Strength / Day Time",
"Cold Relief Multi Symptom",
"Cold Relief Multi Symptom",
"Cold Relief Multi Symptom",
"Cold Relief Multi Symptom Nighttime",
"Cold Relief Multi Symptom Severe",
"Cold Relief Multi-Symptom",
"Cold Relief Multi-Symptom",
"Cold Relief Multi-Symptom",
"Cold Relief Multi-Symptom",
"Cold Relief Multi-Symptom",
"Cold Relief Multi-Symptom",
"Cold Relief Multi-Symptom",
"Cold Relief Multi-symptom",
"Cold Relief Multi-symptom",
"Cold Relief Multi-symptom Daytime",
"Cold Relief Multi-Symptom Daytime",
"Cold Relief Multi-Symptom Severe",
"Cold Relief Multi-symptom, Daytime",
"Cold Relief Multi-Symptom, Daytime, Nighttime, Non-drowsy",
"Cold Relief Multi-Symptom, Daytime, Nighttime, Non-drowsy",
"Cold Relief Non Drowsy",
"Cold Relief Severe",
"Cold Relief Severe Head Congestion",
"Cold Relief Severe Pain Cough",
"Cold Relief Severe, Multi-symptom",
"Cold Severe Congestion",
"Cold Sinus",
"Cold Stix",
"Cold Stix - Hot Lemon, Sugar-free; Sweetened With Xylitol",
"Cold Stix Super Strength",
"Cold Stix-extra Strength",
"Cold Stix-regular Strength",
"Cold Syrup",
"Cold Tabs II",
"Cold Terminator Max",
"Cold-EEZE Childrens Nighttime Cold and Cough Relief",
"Cold-EEZE Daytime Cold and Flu",
"Cold-EEZE Nighttime Cold and Flu",
"Cold-Flu Relief Multi Symptom",
"COLD, Flu and Sore Throat",
"Cold, Flu and Sore Throat",
"Cold, Flu and Sore Throat",
"COLD, Flu and Sore Throat",
"Cold, Flu and Sore Throat Maximum Strength",
"Cold, Flu and Sore Throat Maximum Strength",
"Cold, Flu and Sore Throat Maximum Strength, Multi-Symptom",
"Cold, Flu and Sore Throat Maxium Strength",
"Cold, Flu and Sore Throat Multi-Symptom",
"Cold, Flu and Sore Throat Relief Maximum Strength, Multi Symptom",
"Cold, Flu and Sore Throat Relief Maximum Strength, Multi Symptom",
"Cold, Flu, and Sore Throat",
"Cold, Flu, and Sore Throat",
"Cold, Flu, and Sore Throat",
"Cold/Flu Multi-Symptom Relief Daytime/Nighttime",
"Cold/Flu Multi-Symptom Relief Daytime/Nighttime",
"ColdaeWon Nose A",
"ColdaeWon Nose A Syrup",
"Coldcough PD",
"Colds & Coughs",
"COLDTAC Plus",
"COLDTAC Plus",
"Coldtac Plus Softgels",
"Coldtac Ultra",
"Coldtac Ultra",
"Coltalin",
"Coltalin Cold & Allergy Tablets",
"Coltalin-DM",
"Coltalin-ND",
"Coltalin-ND",
"Complete Allergy and Sinus Multi Symptom",
"Complete Cold & Flu Relief",
"Complete Cold Relief",
"Complete Cold Relief",
"Complete One Cold and Flu PE Night",
"Comtrex Cough and Cold Day/Night",
"Comtrex Cough and Cold Day/Night",
"COMTREX Maximum Strength Cold and Cough Non-Drowsy",
"COMTREX Maximum Strength Day / Night Severe Cold and Sinus",
"COMTREX Maximum Strength Day / Night Severe Cold and Sinus",
"Congestaid II",
"Congestaid II",
"Congestion and Cough Childrens",
"Congestion and Headache",
"Congestion and Headache",
"Congestion and Headache",
"Congestion PE",
"Congestion PE",
"Congestion PE",
"Congestion Relief",
"Congestion Relief",
"Congestion Relief",
"Congestion Relief",
"Congestion Relief",
"ConRx Allergy Sinus",
"ConRx Allergy Sinus Multi-Symptoms",
"ConRx Cold",
"ConRx Cold",
"ConRX DayTime",
"ConRX Pain Reliever Sinus Headache",
"ConRx Sinus",
"ConRx Sinus",
"Contac",
"Contac Cold & Sinus Extra Strength",
"Contac Cold & Sinus Hot Medicated Drink",
"Contac Cold and Flu Day",
"Contac Cold and Flu Day Night",
"Contac Cold and Flu Day Night",
"Contac Cold and Flu Day Night",
"Contac Cold and Flu Day Night",
"Contac Cold and Flu Day Night",
"Contac Cold and Flu Maximum Strength",
"Contac Cold and Flu Night",
"Contac Cold Chest Congestion",
"Contac Cold Nasal Congestion",
"Contac Gold",
"Cooling Hemorrhoidal",
"Cooling Severe Daytime",
"Cooling Severe Daytime",
"Cooling Severe Daytime Cooling Severe Nighttime",
"Cooling Severe Daytime Cooling Severe Nighttime",
"Cooling Severe Daytime Cooling Severe Nighttime",
"Cooling Severe Daytime Cooling Severe Nighttime",
"Cooling Severe Nighttime",
"Cooling Severe Nighttime",
"Core Values Tussin CF",
"Corfen DM",
"Corfen DM",
"Coristine-DH Liq",
"Corzall PE",
"Cough & Cold",
"Cough & Cold Relief",
"Cough & Congestion",
"Cough and Cold Berry & Green Tea Flavor Extra Strength",
"Cough and Cold Nighttime",
"Cough and Cold plus",
"Cough and Cold XL3 Xtra",
"Cough and Cold XL3 Xtra",
"Cough and Cold XL3 Xtra",
"Cough and Cold XL3 Xtra",
"cough and sinus PE",
"Cough and Sinus PE Pressure, Pain and Cough Non-Drowsy",
"Cough Cold and Sore Throat Childrens",
"Cough Formula Cough and Cold",
"Cough Multi Symptom",
"Cough Syrup",
"Cough Syrup DM Decongestant",
"Cough Syrup DM Decongestant and Expectorant With Acetaminophen",
"Cough Syrup DM Decongestant and Expectorant With Acetaminophen Extra Strength",
"Cough Syrup DM Decongestant for Children",
"Cough Syrup DM-decongestant Expectorant",
"Cough Syrup DM-decongestant-expectorant Extra Strength",
"Cough Tussin",
"Cough, Cold & Allergy Relief",
"CounterAct Day",
"CounterAct Day",
"CounterAct Night",
"CounterAct Night",
"Covideze",
"Crane Safety Cold Relief",
"Crane Safety Sinus Decongestant",
"Crantex",
"Crantex",
"Cvs",
"CVS - Childrens Mucus Relief Cough, Cold and Sore Throat",
"CVS - Childrens Stuffy Nose and Cold",
"CVS Chest Congestion Relief PE",
"Cvs Children Decongestant Nose Drops",
"CVS Childrens Cold and Allergy",
"CVS Childrens Nighttime Multi Symptom Cold",
"CVS cough and severe cold night time honey lemon infused with chamomile and white tea flavors",
"CVS day time cough and severe cold berry infused with menthol and green tea flavors",
"CVS Daytime and Nighttime Severe Cold and Flu Relief Bundle",
"CVS Daytime and Nighttime Severe Cold and Flu Relief Bundle",
"CVS DayTime and NightTime Value Pack Cold and Flu",
"CVS DayTime and NightTime Value Pack Cold and Flu",
"CVS Daytime Cold and Flu Relief",
"CVS Daytime COLD and FLU RELIEF and Nighttime COLD and FLU RELIEF",
"CVS Daytime COLD and FLU RELIEF and Nighttime COLD and FLU RELIEF",
"CVS Daytime COLD and FLU RELIEF and Nighttime COLD and FLU RELIEF",
"CVS Daytime COLD and FLU RELIEF and Nighttime COLD and FLU RELIEF",
"CVS Daytime Severe Cold and Flu Relief Softgels",
"CVS Daytime Severe Cough and Cold",
"CVS DT and NT Combo Pack Cold and Flu",
"CVS Health",
"CVS Health Chest Congestion Relief PE",
"CVS Health Daytime Severe Cold and Flu Relief",
"CVS Health Extra Strength Sinus Relief Nasal Decongestant",
"CVS Health Four Actions Nasal Decongestant",
"Cvs Health Hemorrhoidal Cooling Hemorrhoidal",
"CVS Health Hemorrhoidal Cream",
"CVS Health Maximum Strength Non Drowsy Day and Night Cold and Flu Max Softgels Minis",
"CVS Health Maximum Strength Non Drowsy Day and Night Cold and Flu Max Softgels Minis",
"CVS Health Multi Symptom Severe Cold MULTI SYMPTOM SEVERE COLD",
"CVS Health Nighttime Severe Cough and Cold Nighttime Severe Cold and Cough",
"CVS Health Non Drowsy DAY Cold and Flu Plus and NIGHTTIME Cold and Flu Plus",
"CVS Health Non Drowsy DAY Cold and Flu Plus and NIGHTTIME Cold and Flu Plus",
"CVS Health Non Drowsy Daytime Cold and Flu Relief And Nighttime Cold and Flu Relief Day and Night Twin Pack",
"CVS Health Non-Drowsy Daytime Cold and Flu Relief Single Serve Cups Daytime",
"CVS Hemorrhoidal",
"CVS Hemorrhoidal",
"Cvs Hemorrhoidal Cooling",
"CVS Maximum Strength Cold and Flu Relief",
"CVS Maximum Strength Cold and Flu Relief",
"CVS Maximum Strength Severe Congestion and Cough",
"CVS Maximum Strength Severe Congestion and Cough Overnight Cold and Flu Clear and cool",
"CVS Maximum Strength Severe Congestion and Cough Overnight Cold and Flu Clear and cool",
"CVS NightTime Cold",
"CVS Nighttime Severe Cold and Flu Relief",
"CVS Overnight Cold and Flu Clear and Cool",
"CVS Pharmacy Cold and Sore Throat Lemon Flavor",
"CVS Pharmacy Daytime Nighttime Severe Cold and Cough Kit",
"CVS Pharmacy Daytime Nighttime Severe Cold and Cough Kit",
"CVS Pharmacy Daytime Severe Cough and Cold Berry infused with Menthol and Green Tea flavors",
"CVS Pharmacy Nighttime Severe Cough and Cold honey lemon infused with chamomile and white tea flavors",
"CVS Severe Congestion and Pain Relief",
"CVS Severe Multi-Symptom Cough Cold Flu",
"Cyclomydril",
"D - Time",
"D Time Sinus",
"Dallergy",
"Dallergy",
"Dallergy",
"Dallergy",
"Dallergy",
"Dallergy",
"Dallergy",
"Dallergy",
"Dallergy DROPS",
"Dallergy DROPS",
"Dallergy PE",
"Dallergy PE SYRUP",
"Day & Night Combo Pack",
"Day and Night Cold",
"Day and Night Cold",
"Day and Night Cold and Flu Formula",
"Day and Night Cold and Flu Formula",
"Day and Night Cold PE",
"Day and Night Cold PE",
"Day and Night Cold Symptom Relief",
"Day and Night Cold Symptom Relief",
"Day and Night Severe Sinus Congestion and Cough Maximum Strength",
"Day and Night Severe Sinus Congestion and Cough Maximum Strength",
"Day and Night Severe Sinus Congestion and Cough Maximum Strength",
"Day and Night Severe Sinus Congestion and Cough Maximum Strength",
"Day and Night Sinus",
"Day and Night Sinus",
"Day and Night Sinus Maximum Strength",
"Day and Night Sinus Maximum Strength",
"Day and Night Sinus Relief Maximum Strength",
"Day and Night Sinus Relief Maximum Strength",
"Day Cold and Flu Night Cold and Flu",
"Day Cold and Flu Night Cold and Flu",
"DAY Cold and Flu Plus and NIGHTTIME Cold and Flu Plus",
"DAY Cold and Flu Plus and NIGHTTIME Cold and Flu Plus",
"DAY Cold and Flu Plus and NIGHTTIME Cold and Flu Plus",
"DAY Cold and Flu Plus and NIGHTTIME Cold and Flu Plus",
"Day Cold and Flu Relief",
"Day Maximum Strength Cold and Flu Relief",
"Day Maximum Strength Cold and Flu Relief",
"Day Night Cold and Flu",
"Day Relief Night Relief Free",
"Day Relief Night Relief Sinus PE",
"Day Relief Night Relief Sinus PE",
"Day Relief PE",
"Day Relief Sinus PE",
"Day Severe Cold and Night Cold and Flu Maximum Strength",
"Day Severe Cold and Night Cold and Flu Maximum Strength",
"Day Severe Cold and Night Cold and Flu Maximum Strength",
"Day Severe Cold and Night Cold and Flu Maximum Strength",
"Day Severe Cold Night Cold and Flu",
"Day Severe Cold Night Cold and Flu",
"Day Severe Cold Night Cold and Flu",
"Day Severe Cold Night Cold and Flu",
"Day Time",
"Day Time",
"Day Time",
"Day Time",
"Day Time",
"Day Time",
"DAY TIME and NIGHT TIME COLD and FLU FORMULA",
"DAY TIME and NIGHT TIME COLD and FLU FORMULA",
"Day Time and Night Time Sinus and Congestion",
"Day Time and Night Time Sinus and Congestion",
"Day Time Cold and Flu",
"Day time cold and flu",
"Day time cold and flu",
"Day Time Cold and Flu",
"Day Time Cold and Flu",
"Day Time Cold and Flu cold and flu multi symptom relief",
"DAY TIME COLD and FLU FORMULA",
"Day Time Cold and Flu Multi-Symptom Relief",
"Day Time Cold and Flu Non drowsy",
"Day Time Cold and Flu non drowsy",
"Day Time Cold and Flu non drowsy",
"Day Time Cold and Flu Non Drowsy ReadyInCase",
"Day Time COLD and FLU non-drowsy",
"Day Time Cold and Flu Relief",
"Day Time Cold and Flu Relief",
"Day Time Cold and Flu Relief non drowsy",
"Day Time Cold and Flu Severe",
"DAY TIME Cold Flu Medicine",
"DAY TIME Cold Flu Medicine",
"Day Time Cold Flu Relief",
"Day Time Cold Head Congestion Severe",
"Day Time Cold Multi-Symptom",
"Day Time Cold Multi-Symptom Cool Blast",
"Day Time Cold non drowsy cold and Flu Relief",
"Day Time Cold/Flu Relief",
"Day Time Cold/Flu Relief",
"Day Time Gelcap",
"Day Time Gelcap",
"Day Time Multi-Symptom Cold/Flu Relief",
"Day Time Multi-Symptom Flu Cold Medicine",
"Day Time Night Time",
"Day Time Night Time",
"Day Time Night Time Cold and Flu",
"Day Time Night Time Cold and Flu",
"Day Time Night Time Cold and Flu",
"Day Time Night Time Severe Cold and Flu",
"Day Time Night Time Severe Cold and Flu",
"Day Time Night Time Sinus Relief",
"Day Time Night Time Sinus Relief",
"Day Time Non Drowsy",
"Day Time Non-Drowsy Cold - Flu Relief",
"Day Time PE cold and flu relief",
"Day Time Severe",
"Day Time Severe Cold and Cough",
"Day Time Sinus",
"Day Time Sinus Pain Reliever, Nasal Decongestant",
"Day Time Sinus Relief",
"Day Time Softgels",
"Day Time with PE",
"Day Time with PE",
"Day Time with PE",
"Day Time with PE",
"Day Time with PE",
"Day Time with PE",
"Day Time with PE",
"Day Time with PE",
"Day Time with PE",
"Day Time with PE",
"Day-night Cold and Flu",
"Day-night Cold and Flu",
"Day-night Severe Cold and Flu",
"Day-night Severe Cold and Flu",
"DAY-TIME Cold and Flu",
"Day-Time Cold and Flu Relief",
"Day-Time Night-Time",
"Day-Time NON-DROWSY COLD/FLU RELIEF",
"Daycap Cold & Flu Liquid Gels",
"Daycap Cold and Flu Liquid Gels",
"Daycap Sinus Liquid Gels",
"Daycap Sinus Liquid Gels",
"DayClear COUGH COLD AND FLU",
"DayClear SINUS PAIN AND PRESSURE",
"DayQuil and Nyquil Severe plus Vicks VapoCool Cold and Flu",
"DayQuil and Nyquil Severe plus Vicks VapoCool Cold and Flu",
"DayQuil and NyQuil VapoCOOL SEVERE COLD and FLU plus CONGESTION",
"DayQuil and NyQuil VapoCOOL SEVERE COLD and FLU plus CONGESTION",
"Dayquil Cold & Flu",
"DayQuil Cold and Flu",
"Dayquil Complete",
"Dayquil Complete + Vicks Vapocool",
"Dayquil Complete + Vicks Vapocool Cold & Flu Liquid",
"Dayquil Cough DM + Congestion",
"DayQuil Severe",
"DayQuil Severe",
"DayQuil Severe Cold and Flu",
"DayQuil Severe Plus VapoCOOL Cold And Flu",
"Dayquil Severe Plus Vapocool Cold and Flu",
"DayQuil Severe plus VapoCOOL Cold and Flu, CVP HEALTH",
"DayQuil Severe plus VapoCOOL Cold and Flu, Travel BASIX",
"DayQuil Severe plus Vicks VapoCool",
"DayQuil Severe plus Vicks VapoCool",
"DayQuil Severe plus Vicks VapoCool Cold and Flu",
"DayQuil Severe Plus Vicks Vapocool Cold and Flu",
"DayQuil Severe VapoCool",
"Dayquil Sinus Liquicaps",
"DayQuil VapoCOOL SEVERE COLD and FLU plus CONGESTION",
"DayRelief Multi symptom",
"DayRelief NON DROWSY MULTI SYMPTOM COLD FLU",
"Dayrelief PE",
"Daytime",
"Daytime",
"DayTime",
"Daytime",
"Daytime",
"DayTime",
"Daytime",
"Daytime",
"Daytime",
"Daytime and Nighttime Cold and Flu",
"DAYTIME and Nighttime Cold and Flu",
"DAYTIME and Nighttime Cold and Flu",
"Daytime and Nighttime Cold and Flu",
"Daytime and Nighttime Cold and Flu",
"DayTime and NightTime Cold and Flu",
"Daytime and Nighttime Cold and Flu Maximum Strength",
"Daytime and Nighttime Cold and Flu Maximum Strength",
"Daytime and Nighttime Cold and Flu Relief",
"Daytime and Nighttime Cold and Flu Relief",
"Daytime and Nighttime Cold and Flu Relief Plus",
"Daytime and Nighttime Cold and Flu Relief Plus",
"Daytime and Nighttime Cold/Flu Relief",
"DAYTIME and NIGHTTIME SEVERE COLD AND FLU DAYTIME NON DROWSY NIGHTTIME",
"DAYTIME and NIGHTTIME SEVERE COLD AND FLU DAYTIME NON DROWSY NIGHTTIME",
"Daytime and Nighttime Sinus Congestion PE",
"Daytime and Nighttime Sinus Congestion PE",
"DAYTIME and Nighttime Sinus Relief",
"DAYTIME and Nighttime Sinus Relief",
"Daytime and Nighttime Sinus Relief",
"Daytime and Nighttime Sinus Relief",
"DayTime and NiteTime",
"Daytime Cold",
"Daytime Cold & Flu Relief",
"Daytime Cold & Flu Relief",
"Daytime Cold and Cough and NightTime Cold and Congestion Childrens",
"Daytime Cold and Cough and NightTime Cold and Congestion Childrens",
"Daytime Cold and Cough and NightTime Cold and Congestion Childrens",
"Daytime Cold and Cough and NightTime Cold and Congestion Childrens",
"DayTime Cold and Cough Childrens",
"DayTime Cold and Flu",
"Daytime Cold and Flu",
"DayTime Cold and Flu",
"DayTime Cold and Flu",
"DayTime Cold and Flu",
"DayTime Cold and Flu",
"Daytime Cold and Flu",
"Daytime Cold and Flu",
"Daytime Cold and Flu",
"DayTime Cold and Flu",
"Daytime Cold and Flu",
"DayTime Cold and Flu",
"Daytime Cold and Flu",
"Daytime Cold and Flu",
"DayTime Cold and Flu",
"Daytime Cold and Flu",
"Daytime Cold and Flu",
"Daytime Cold and Flu",
"Daytime Cold and Flu",
"Daytime Cold and Flu",
"DayTime Cold and Flu",
"Daytime Cold and Flu",
"DayTime Cold and Flu",
"Daytime Cold and Flu",
"DAYTIME COLD and FLU",
"Daytime Cold and Flu",
"Daytime Cold and Flu",
"Daytime Cold and Flu",
"Daytime Cold and Flu",
"Daytime Cold and Flu",
"Daytime Cold and Flu",
"Daytime Cold and Flu",
"Daytime Cold and Flu",
"Daytime Cold and Flu",
"Daytime Cold and Flu",
"Daytime Cold and Flu",
"Daytime Cold and Flu",
"Daytime Cold and Flu",
"Daytime Cold and Flu",
"Daytime Cold and Flu",
"DayTime Cold and Flu",
"Daytime Cold and Flu",
"Daytime Cold and Flu",
"Daytime cold and flu",
"Daytime Cold and Flu and Nighttime Cold and Flu",
"Daytime Cold and Flu and Nighttime Cold and Flu",
"Daytime Cold and Flu and Nigttime Cold and Flu",
"Daytime Cold and Flu Lil Drug Store Products",
"Daytime Cold and Flu Liquid Gels",
"DAYTIME COLD AND FLU Maximum Strength",
"Daytime Cold and Flu multi symptom",
"Daytime Cold and Flu Multi Symptom",
"Daytime Cold and Flu Multi symptom relief",
"Daytime Cold and Flu Multi symptom relief",
"Daytime Cold and Flu Multi-symptom Relief",
"Daytime Cold and Flu Multi-symptom Relief",
"Daytime Cold and Flu Nighttime Cold and Flu",
"Daytime Cold and Flu Nighttime Cold and Flu",
"Daytime Cold and Flu Nighttime Cold and Flu",
"Daytime Cold and Flu Nighttime Cold and Flu",
"Daytime Cold and Flu Nitetime Cold and Flu",
"Daytime Cold and Flu Nitetime Cold and Flu",
"Daytime cold and flu non drowsy",
"DayTime Cold and Flu Non Drowsy",
"Daytime Cold and Flu Non Drowsy",
"Daytime Cold and Flu Non Drowsy",
"Daytime Cold and Flu Non Drowsy",
"Daytime Cold and Flu Non Drowsy",
"Daytime Cold and Flu Non Drowsy",
"Daytime Cold and Flu Non drowsy",
"DayTime Cold and Flu Non Drowsy",
"Daytime Cold and Flu Non Drowsy",
"Daytime Cold and Flu Non Drowsy",
"Daytime Cold and Flu Non drowsy",
"Daytime Cold and Flu Non Drowsy",
"Daytime Cold and Flu Non Drowsy",
"DayTime Cold and Flu Non Drowsy",
"Daytime Cold and Flu Non Drowsy",
"Daytime Cold and Flu Non Drowsy",
"DayTime Cold and Flu Non Drowsy",
"Daytime Cold and Flu Non Drowsy",
"Daytime Cold and Flu Non drowsy",
"Daytime cold and flu relief",
"Daytime Cold and Flu Relief",
"Daytime Cold and Flu Relief",
"DayTime Cold and Flu Relief",
"Daytime Cold and Flu Relief",
"Daytime Cold and Flu Relief",
"Daytime Cold and Flu Relief",
"Daytime Cold and Flu Relief",
"Daytime Cold and Flu Relief",
"Daytime Cold and Flu Relief",
"Daytime cold and flu relief",
"DAYTIME cold and flu relief",
"Daytime Cold and Flu Relief",
"Daytime Cold and Flu Relief",
"Daytime Cold and Flu Relief",
"Daytime cold and flu relief",
"Daytime Cold and Flu Relief",
"Daytime Cold and Flu Relief",
"Daytime Cold and Flu relief",
"Daytime Cold and Flu Relief",
"Daytime Cold and Flu Relief",
"DayTime Cold and Flu Relief",
"Daytime Cold and Flu Relief",
"Daytime Cold and Flu Relief Multi-Symptom",
"Daytime Cold and Flu Relief Multi-Symptom",
"Daytime Cold and Flu Relief Non Drowsy",
"Daytime Cold and Flu Relief Non Drowsy",
"Daytime Cold and Flu Relief Non Drowsy",
"Daytime Cold and Flu Relief Non Drowsy",
"Daytime Cold and Flu Relief Non Drowsy",
"Daytime Cold and Flu Relief Non Drowsy",
"Daytime Cold and Flu Relief Plus",
"DayTime Cold and Flu Severe and NightTime Cold and Flu Severe",
"DayTime Cold and Flu Severe and NightTime Cold and Flu Severe",
"Daytime Cold and Flu Severe, Caseys 4goog",
"Daytime Cold and Pain Relief",
"Daytime Cold Cough Childrens",
"Daytime Cold Flu",
"Daytime Cold Flu multi Symptom",
"Daytime Cold Flu multi Symptom",
"Daytime Cold Flu multi Symptom",
"DayTime Cold Flu Non Drowsy",
"DayTime Cold Flu Non Drowsy",
"Daytime Cold Flu Non Drowsy",
"DayTime Cold Flu Non Drowsy",
"DayTime Cold Flu Non-Drowsy",
"Daytime Cold Flu Relief",
"Daytime Cold Relief Extra Strength",
"Daytime Cold Relief Extra Strength Tablets PE",
"Daytime Cold Relief Liquid Gels",
"Daytime Cold Relief Multi Symptom",
"Daytime Cold, Nighttime Cold multi-symptom",
"Daytime Cold, Nighttime Cold multi-symptom",
"Daytime Cold/flu Medicine",
"Daytime Cold/Flu Relief Softgels",
"Daytime Complete",
"Daytime Congestion and Pain Sinus Relief",
"Daytime Congestion Pressure and Pain",
"Daytime Congestion Pressure and Pain",
"Daytime Cough",
"Daytime Cough & Cold",
"Daytime Cough And Cold",
"Daytime Cough and Cold",
"Daytime Cough Cold & Flu Liquid Gels",
"Daytime Fast Severe Cold Relief Nitetime Fast Cold and Flu Relief",
"Daytime Fast Severe Cold Relief Nitetime Fast Cold and Flu Relief",
"Daytime Flu and Severe",
"Daytime Flu Relief Therapy",
"Daytime Flu Relief Therapy Severe Cough and Cold",
"Daytime Liquid Caps",
"Daytime Liquid Caps",
"Daytime Liquid Caps",
"DayTime Maximum Strength Cold and Flu",
"Daytime Mucus Relief Nighttime Cold and Flu",
"Daytime Mucus Relief Nighttime Cold and Flu",
"Daytime Mucus Relief Severe Cold and Nighttime Cold and Flu Maximum Strength",
"Daytime Mucus Relief Severe Cold and Nighttime Cold and Flu Maximum Strength",
"DayTime Mucus Relief Severe Cold and Nighttime Cold and Flu Maximum Strength",
"DayTime Mucus Relief Severe Cold and Nighttime Cold and Flu Maximum Strength",
"DayTime Mucus Relief Severe Cold and Nighttime Cold and Flu Maximum Strength",
"DayTime Mucus Relief Severe Cold and Nighttime Cold and Flu Maximum Strength",
"Daytime Mucus Relief Severe Cold and Nighttime Cold and Flu Maximum Strength",
"Daytime Mucus Relief Severe Cold and Nighttime Cold and Flu Maximum Strength",
"Daytime Mucus Relief Severe Cold and Nighttime Cold and Flu Maximum Strength",
"Daytime Mucus Relief Severe Cold and Nighttime Cold and Flu Maximum Strength",
"Daytime Mucus Relief Severe Cold and Nighttime Cold and Flu Maximum Strength",
"Daytime Mucus Relief Severe Cold and Nighttime Cold and Flu Maximum Strength",
"Daytime Mucus Relief Severe Cold and Nighttime Cold and Flu Maximum Strength",
"Daytime Mucus Relief Severe Cold and Nighttime Cold and Flu Maximum Strength",
"Daytime Mucus Relief Severe Cold Nighttime Cold and Flu Maximum Strength",
"Daytime Mucus Relief Severe Cold Nighttime Cold and Flu Maximum Strength",
"Daytime Mucus Relief Severe Cold Nighttime Cold and Flu Maximum Strength",
"Daytime Mucus Relief Severe Cold Nighttime Cold and Flu Maximum Strength",
"Daytime Mucus Relief Severe Cold Nighttime Cold and Flu Maximum Strength",
"Daytime Mucus Relief Severe Cold Nighttime Cold and Flu Maximum Strength",
"Daytime Mucus Relief Severe Cold Nighttime Cold and Flu Maximum Strength",
"Daytime Mucus Relief Severe Cold Nighttime Cold and Flu Maximum Strength",
"Daytime Mucus Relief Severe Cold/Nighttime Mucus Relief Cold and Flu",
"Daytime Mucus Relief Severe Cold/Nighttime Mucus Relief Cold and Flu",
"Daytime Mucus Relief Severe Congestion and Cough and Nighttime Cold and Flu Maximum Strength",
"Daytime Mucus Relief Severe Congestion and Cough and Nighttime Cold and Flu Maximum Strength",
"Daytime Mucus Relief Severe Congestion and Cough and Nighttime Cold and Flu Maximum Strength",
"Daytime Mucus Relief Severe Congestion and Cough and Nighttime Cold and Flu Maximum Strength",
"DayTime Multi-Symptom",
"Daytime Multi-Symptom Cold Relief",
"Daytime Multi-symptom Cold Relief",
"Daytime Multi-Symptom Cold/Flu Relief",
"DayTime Multi-Symptom Flu Cold Medicine",
"Daytime Multi-Symptom Non-Drowsy Cold and Flu",
"Daytime Nightime Severe Cold",
"Daytime Nightime Severe Cold",
"Daytime Nighttime",
"Daytime Nighttime",
"DayTime Nighttime",
"Daytime Nighttime",
"Daytime Nighttime",
"Daytime Nighttime ClearTime",
"Daytime Nighttime ClearTime",
"Daytime Nighttime Cold and Cough",
"Daytime Nighttime Cold and Cough Childrens",
"Daytime Nighttime Cold and Cough Childrens",
"Daytime Nighttime Cold and Cough Childrens",
"Daytime Nighttime Cold and Cough Childrens",
"DAYTIME NIGHTTIME Cold and Flu",
"DayTime NightTime Cold and Flu",
"Daytime Nighttime Cold and Flu",
"Daytime Nighttime Cold and Flu",
"Daytime Nighttime Cold and Flu",
"Daytime Nighttime Cold and Flu",
"Daytime Nighttime Cold and Flu",
"Daytime Nighttime Cold and Flu",
"Daytime Nighttime Cold and Flu",
"Daytime Nighttime Cold and Flu",
"Daytime Nighttime Cold and Flu",
"Daytime Nighttime Cold and Flu",
"Daytime Nighttime Cold and Flu",
"Daytime Nighttime Cold and Flu",
"Daytime Nighttime Cold and Flu",
"Daytime Nighttime Cold and Flu",
"Daytime Nighttime Cold and Flu",
"Daytime Nighttime Cold and Flu",
"Daytime Nighttime cold and flu relief",
"Daytime Nighttime cold and flu relief",
"Daytime Nighttime Cold and Flu Relief",
"Daytime Nighttime Cold and Flu Relief",
"DayTime NightTime Cold and Flu Relief",
"Daytime Nighttime Cold and Flu Relief Combo Pack",
"Daytime Nighttime Cold and Flu Relief Multi-Symptom",
"Daytime Nighttime Cold and Flu Relief Multi-Symptom",
"Daytime Nighttime Cold and Flu Relief Multi-Symptom",
"Daytime Nighttime Cold and Flu Relief Multi-Symptom",
"Daytime Nighttime Cold and Flu Relief Multi-Symptom",
"Daytime Nighttime Cold and Flu Relief Multi-Symptom",
"Daytime Nighttime Cold and Flu Relief Multi-Symptom",
"Daytime Nighttime Cold and Flu Relief Multi-Symptom",
"Daytime Nighttime Cold and Flu Relief Multi-Symptom",
"Daytime Nighttime Cold and Flu Relief Multi-Symptom",
"Daytime Nighttime Cold and Flu Relief Multi-Symptom",
"Daytime Nighttime Cold and Flu Relief Multi-Symptom",
"Daytime Nighttime Cold and Flu Relief Multi-Symptom",
"Daytime Nighttime Cold and Flu Relief Multi-Symptom",
"Daytime Nighttime Cold and Flu Relief Multi-Symptom",
"Daytime Nighttime Cold and Flu Relief Multi-Symptom",
"Daytime Nighttime Cold Flu Relief",
"Daytime Nighttime Cold Flu Relief",
"Daytime Nighttime Cold Flu Relief",
"Daytime Nighttime Cold Flu Relief",
"Daytime Nighttime Cold Flu Relief",
"Daytime Nighttime Cold Flu Relief",
"Daytime Nighttime Cold Flu Relief",
"Daytime Nighttime Cold Flu Relief",
"Daytime Nighttime Cold Flu Relief",
"Daytime Nighttime Cold Flu Relief",
"Daytime Nighttime Cold Flu Relief",
"Daytime Nighttime Cold Flu Relief",
"Daytime Nighttime Cold Flu Relief",
"Daytime Nighttime Cold Flu Relief",
"Daytime Nighttime Cold Flu Relief",
"Daytime Nighttime Cold Flu Relief",
"Daytime Nighttime Cold Flu Relief",
"Daytime Nighttime Cold Flu Relief",
"Daytime Nighttime Cold Flu Relief",
"Daytime Nighttime Cold Flu Relief",
"Daytime Nighttime Cold Flu Relief",
"Daytime Nighttime Cold Flu Relief",
"Daytime Nighttime Cold Flu Relief",
"Daytime Nighttime Cold Flu Relief",
"Daytime Nighttime Cold Flu Relief",
"Daytime Nighttime Cold Flu Relief",
"Daytime Nighttime Cold Flu Relief",
"Daytime Nighttime Cold Flu Relief",
"Daytime Nighttime Cold Flu Relief",
"Daytime Nighttime Cold Flu Relief",
"Daytime Nighttime Cold Flu Relief Multi Symptom",
"Daytime Nighttime Cold/Flu",
"Daytime Nighttime Cold/flu",
"Daytime Nighttime Cold/flu",
"DayTime NightTime Cold/Flu",
"DayTime NightTime Cold/Flu",
"DayTime NightTime Cold/Flu",
"Daytime Nighttime Cold/flu Relief A P J",
"Daytime Nighttime Multi Symptom Cold and Flu Relief",
"DayTime Nighttime multi symptom cold and flu relief",
"Daytime Nighttime Multi Symptom Cold Childrens",
"Daytime Nighttime Multi Symptom Cold Childrens",
"Daytime Nighttime Multi Symptom Cold Flu Relief",
"Daytime Nighttime Severe Cold",
"Daytime Nighttime Severe Cold",
"Daytime Nighttime Severe Cold and Flu",
"Daytime Nighttime Severe Cold and Flu",
"Daytime Nighttime Severe Cold and Flu",
"Daytime Nighttime Severe Cold and Flu",
"Daytime Nighttime Severe Cold and Flu",
"Daytime Nighttime Severe Cold and Flu",
"Daytime Nighttime Severe Cold and Flu",
"Daytime Nighttime Severe Cold and Flu",
"DAYTIME NIGHTTIME SEVERE COLD AND FLU Maximum Strength",
"DAYTIME NIGHTTIME SEVERE COLD AND FLU Maximum Strength",
"Daytime Nighttime Severe Cold and Flu Relief",
"Daytime Nighttime Severe Cold and Flu Relief",
"Daytime Nighttime Severe Cold and Flu Relief",
"Daytime Nighttime Severe Cold and Flu Relief",
"Daytime Nighttime Severe Cold and Flu Relief",
"Daytime Nighttime Severe Cold and Flu Relief",
"Daytime Nighttime Severe Cold and Flu Relief",
"Daytime Nighttime Severe Cold and Flu Relief",
"Daytime Nighttime Severe Cold Cough and Flu Relief",
"Daytime Nighttime Severe Cold Cough and Flu Relief",
"Daytime Nighttime Severe Cough and Cold",
"Daytime Nighttime Severe Cough and Cold",
"DayTime NightTime Sinus Relief",
"DayTime NightTime Sinus Relief",
"Daytime Nighttime Sinus Relief",
"Daytime Nighttime Sinus Relief",
"Daytime Nighttime Sinus Relief Maximum Strength",
"Daytime Nighttime Sinus Relief Maximum Strength",
"Daytime Nighttime Sinus Relief Maximum Strength",
"Daytime Nighttime Sinus Relief Maximum Strength",
"Daytime Nighttime Sinus Relief Maximum Strength",
"Daytime Nighttime Sinus Relief Maximum Strength",
"Daytime Nighttime Sinus Relief Maximum Strength",
"Daytime Nighttime Sinus Relief Maximum Strength",
"Daytime Nighttime Sinus Relief Maximum Strength",
"Daytime Nighttime Sinus Relief Maximum Strength",
"Daytime Nighttime Sinus Relief Maximum Strength",
"Daytime Nighttime Sinus Relief Maximum Strength",
"Daytime Nite Time",
"Daytime Nitetime",
"Daytime Nitetime",
"Daytime NiteTime",
"Daytime Nitetime Cold and Flu",
"Daytime Nitetime Cold and Flu",
"Daytime Nitetime Cold and Flu",
"DayTime NiteTime Cold and Flu",
"Daytime Nitetime Cold and Flu",
"Daytime Nitetime Cold and Flu",
"DayTime Nitetime cold and flu relief",
"DayTime NiteTime Cold Flu Relief",
"DayTime NiteTime Severe",
"DayTime NiteTime Severe",
"Daytime Nitetime Sinus",
"Daytime Nitetime Sinus",
"DayTime Nitetime Sinus Relief",
"DayTime Nitetime Sinus Relief",
"Daytime Non Drows Cold and Flu and Nighttime Cold and",
"Daytime Non Drows Cold and Flu and Nighttime Cold and",
"Daytime Non Drowsy",
"Daytime Non Drowsy",
"Daytime Non Drowsy",
"Daytime Non Drowsy",
"Daytime Non Drowsy",
"Daytime Non Drowsy",
"Daytime Non Drowsy",
"Daytime Non-Drowsy Cold and Flu",
"Daytime Non-Drowsy Cold and Flu",
"Daytime Non-Drowsy COLD/FLU",
"Daytime PE",
"Daytime PE Nitetime",
"Daytime PE Nitetime",
"Daytime PE Non Drowsy",
"Daytime Relief Severe Cold and Flu",
"Daytime Severe",
"Daytime Severe",
"Daytime Severe",
"Daytime Severe Cold And Cough",
"Daytime Severe Cold and Cough",
"Daytime Severe Cold and Cough",
"Daytime Severe Cold and Cough",
"Daytime Severe Cold and Cough and Nighttime Severe Cold and Cough",
"Daytime Severe Cold and Cough and Nighttime Severe Cold and Cough",
"DAYTIME SEVERE COLD and COUGH NIGHTTIME SEVERE COLD and COUGH",
"DAYTIME SEVERE COLD and COUGH NIGHTTIME SEVERE COLD and COUGH",
"Daytime Severe Cold and Cough Relief",
"Daytime Severe Cold and Flu",
"Daytime Severe Cold and Flu",
"Daytime Severe Cold and Flu",
"Daytime SEVERE COLD and FLU",
"Daytime Severe Cold and Flu",
"Daytime Severe Cold and Flu",
"Daytime Severe Cold and Flu",
"Daytime Severe Cold and Flu",
"Daytime Severe Cold and Flu",
"Daytime Severe Cold and Flu",
"Daytime Severe Cold and Flu",
"Daytime Severe Cold and Flu Maximum Strength",
"Daytime Severe Cold and Flu Nighttime Severe Cold, Cough and Flu",
"Daytime Severe Cold and Flu Nighttime Severe Cold, Cough and Flu",
"DayTime Severe Cold and Flu Relief",
"Daytime Severe Cold and Flu Relief",
"Daytime Severe Cold and Flu Relief",
"Daytime Severe Cold and Flu Relief",
"DayTime Severe Cold and Flu Relief",
"Daytime Severe Cold and Flu Relief",
"Daytime Severe Cold and Flu Relief",
"DayTime Severe Cold and Flu Relief",
"Daytime Severe Cold And Flu Relief Maximum strength",
"Daytime Severe Cold and Flu Relief Maximum Strength",
"Daytime Severe Cold and Flu Relief Softgels",
"Daytime Severe Cold and Flu Relief Softgels",
"Daytime Severe Cold Multi-symptom",
"Daytime Severe Cold Nighttime Cold and Flu",
"Daytime Severe Cold Nighttime Cold and Flu",
"DayTime Severe Congestion Relief and Nighttime Severe Cough and Congestion Relief Maximum Strength",
"DayTime Severe Congestion Relief and Nighttime Severe Cough and Congestion Relief Maximum Strength",
"Daytime Severe Sinus Congestion and Pain",
"Daytime sinus",
"DayTime Sinus",
"DayTime Sinus",
"DayTime Sinus",
"Daytime Sinus",
"Daytime Sinus and Congestion",
"Daytime Sinus and Congestion",
"Daytime Sinus Nighttime Sinus Maximum Strength",
"Daytime Sinus Nighttime Sinus Maximum Strength",
"Daytime Sinus Nighttime Sinus Maximum Strength",
"Daytime Sinus Nighttime Sinus Maximum Strength",
"Daytime sinus Non Drowsy",
"Daytime Sinus Non-Drowsy",
"Daytime Sinus Pain and Congestion Relief",
"Daytime Sinus Relief",
"DayTime Sinus Relief",
"Daytime Sinus Relief",
"DayTime Sinus Relief",
"DayTime Sinus Relief",
"Daytime Sinus Relief and Nighttime Sinus Relief",
"Daytime Sinus Relief and Nighttime Sinus Relief",
"Daytime Sinus Relief and Nighttime Sinus Relief",
"Daytime Sinus Relief and Nighttime Sinus Relief",
"Daytime Sinus Relief and Nighttime Sinus Relief",
"Daytime Sinus Relief and Nighttime Sinus Relief",
"Daytime Sinus Relief Extra Strength Tablet",
"Daytime Sinus Relief Extra Strength Tablets PE",
"Daytime Sinus Relief Non Drowsy",
"Daytime Sinus Severe",
"Daytime Symptom Relief Extra Strength for Symptoms Of Cold and Cough",
"Daytime- Nighttime Cold and Flu",
"Daytime-nighttime Severe Cold and Flu",
"Daytime-nighttime Severe Cold and Flu",
"Daytime, Nighttime Severe Cold and Flu Relief",
"Daytime, Nighttime Severe Cold and Flu Relief",
"Daytime/Nighttime Cold and Flu Multi-Symptom Relief",
"DayTime/NiteTime Severe Cold and Flu Maximum Strength",
"DayTime/NiteTime Severe Cold and Flu Maximum Strength",
"DCH Hemorrhoidal",
"DCH Rapid Relief Hemorrhoidal",
"Dcp",
"DDM Day time and Nite time cold and flu",
"De-Chlor DM",
"Deconex",
"Deconex DM",
"Deconex Dmx",
"Deconex Dmx",
"Deconex DMX",
"Deconex Ir",
"Deconex IR",
"Decongestant Antihistaminic Syrup",
"Decongestant II",
"Decongestant PE",
"Decongestant PE Non Drowsy",
"Deconsal CT",
"Deconsal DM",
"Defensol D",
"Defensol D (Multi Symptom Effervescent Tablets)",
"Defensol-ito",
"Defensolito",
"Dehistine",
"Delsym Childrens Night Time Cough and Cold",
"Delsym Childrens Night Time Cough and Cold",
"Delsym Cough Plus Chest Congestion DM and Delsym Cough Plus Cold Night Time",
"Delsym Cough Plus Cold Day Time",
"Delsym Cough Plus Cold Day Time",
"Delsym Cough Plus Cold Day Time and Delsym Cough Plus Cold Night Time",
"Delsym Cough Plus Cold Day Time and Delsym Cough Plus Cold Night Time",
"Delsym Cough Plus Cold Night Time",
"Delsym Cough Plus Cold Night Time",
"Delsym Night Time Cough and Cold",
"Delsym Night Time Multi Symptom",
"Dermatool Hemorrhoidal",
"Desenfriol-D",
"Desenfriol-D",
"Desenfriol-D",
"Desgen DM",
"Desgen DM",
"Desgen Pediatric",
"Despec",
"Despec",
"Despec DM",
"Despec DM",
"Despec EDA Drops",
"Despec NR",
"Desresfriol-DX Softgels",
"Dexbrompheniramine Maleate and Phenylephrine Hydrochloride",
"Dexbrompheniramine-DM-Phenylephrine 2-15-7.5",
"Dexchlorpheniramine Maleate, Phenylephrine HCl",
"Dexphen w/ Codeine",
"Dextro Phenyl Pyril",
"DEXTROMETHORPHAN HYDROBROMIDE, Guaifenesin, and PHENYLEPHRINE HYDROCHLORIDE",
"DEXTROMETHORPHAN HYDROBROMIDE, GUAIFENESIN, and PHENYLEPHRINE HYDROCHLORIDE",
"Dextromethorphan Hydrobromide, Guaifenesin, Phenylephrine Hydrochloride",
"Dextromethorphan Tannate, Phenylephrine Tannate, Dexchlorpheniramine Tannate",
"DG Day Time Cold and Flu Formula and Night Time Cold and Flu Formula",
"DG Day Time Cold and Flu Formula and Night Time Cold and Flu Formula",
"DG Health adult tussin multi symptom cold",
"DG health allergy multi symptom",
"DG Health Childrens Cold and Cough",
"Dg Health Childrens Mucus Relief",
"DG Health Cold and Allergy",
"Dg Health Cold and Allergy Childrens",
"Dg Health Cold and Flu",
"Dg Health Cold and Flu Relief",
"Dg Health Cold and Flu Relief",
"Dg Health Cold and Flu Relief",
"DG Health Cold and Flu Relief",
"DG Health Cold and Flu Relief",
"DG Health Cold and Flu Relief Daytime",
"Dg Health Cold and Flu Severe",
"DG Health Cold and Flu Severe",
"DG Health Cold and Flu Severe",
"DG Health Cold Head Congestion",
"Dg Health Cold Head Congestion Severe Day Time",
"DG Health Cold Max",
"DG Health cold multi symptom nite time",
"DG Health cold multi symptom severe",
"Dg Health Cold Plus Flu Relief",
"Dg Health Day Time Severe Cold and Flu",
"Dg Health Day Time Severe Cold and Flu Relief",
"Dg Health Day Time Severe Cold and Flu Relief Night Time Severe Cold and Flu Relief",
"Dg Health Day Time Severe Cold and Flu Relief Night Time Severe Cold and Flu Relief",
"DG Health DayTime SEVERE Cold and Flu",
"DG Health Fast Acting Mucus Relief Severe Cold",
"DG Health Fast Acting Mucus Relief Severe Congestion and Cold",
"Dg Health Flu and Severe Cold and Cough",
"Dg Health Flu and Severe Cold and Cough",
"Dg Health Flu and Severe Cold and Cough",
"Dg Health Hemorrhoidal",
"DG Health Hemorrhoidal",
"DG Health Hemorrhoidal",
"Dg Health Mucus Relief",
"DG Health Mucus Relief",
"DG Health Mucus Relief",
"Dg Health Multi Symptom Severe Cold",
"DG Health nasal decongestant pe maximum strength",
"Dg Health Nasal Four",
"Dg Health Night Time Severe Cold and Flu Relief",
"DG Health NightTime SEVERE Cold and Flu",
"DG Health Pain Relief Cold Night Time",
"Dg Health Sinus Congestion and Pain",
"DG Health Sinus PE",
"DG Health Triacting Childrens",
"Dg Health Triacting Night Time Cold and Cough",
"DG Health Tussin",
"DG Health Tussin",
"Dg Health Tussin",
"DG Health tussin cf adult cough and cold",
"diaCare Childrens Decongestant",
"Dibromm Cold and Allergy Childrens",
"Dibromm Cold and Allergy Relief childrens",
"Dibromm Cold and Cough Childrens",
"DiBromm DM",
"Dibromm DM",
"DiBromm with PE",
"DiBromm with PE",
"DiBromm with PE",
"DiBromm with PE",
"DIBROMM with PE",
"Dibucaine HCl 0.5% / Lidocaine 15% / Phenylephrine HCl 1% / Prilocaine 5%",
"Dihydrocodeine BPM Phenyleph HCl",
"Dihydrocodeine/ BPM/ Phenyleph HCl",
"Dilotab II",
"Dilotab II",
"Dilotab II",
"Dimacol",
"Dimaphen",
"Dimaphen",
"Dimaphen",
"Dimaphen DM",
"Dimaphen DM",
"Dimetane Expectorant C",
"Dimetane Expectorant Dc",
"Dimetane Expectorant Liq",
"Dimetane Expectorant-C Syr",
"Dimetane Expectorant-DC Syr",
"Dimetapp",
"Dimetapp Chewables for Kids",
"Dimetapp Cold & Sinus",
"Dimetapp Cold and Allergy",
"Dimetapp Cold and Cough",
"Dimetapp Cold and Cough and Dimetapp Nighttime Cold and Congestion",
"Dimetapp Cold and Cough and Dimetapp Nighttime Cold and Congestion",
"Dimetapp Cold and Cough and Nighttime Cold and Congestion",
"Dimetapp Cold and Cough and Nighttime Cold and Congestion",
"Dimetapp DM Cough & Cold",
"Dimetapp DM Elixir",
"Dimetapp DM Tab",
"Dimetapp Elixir",
"Dimetapp Extentabs",
"Dimetapp Extra Strength",
"Dimetapp Extra Strength DM Cough & Cold",
"Dimetapp Multi-Symptom Cold and Flu",
"Dimetapp Nighttime Cold and Congestion",
"Dimetapp Nighttime Cold Extra Strength Caplets",
"Dimetapp Nighttime Cold Tablets",
"Dimetapp Oral Infant Cold and Fever Drops",
"Dimetapp Oral Infant Cold Drops",
"Dimetapp Oral Infant Drops",
"Dimetapp Tab",
"Dimetapp-C",
"Dimetapp-C Syr",
"Diophenyl-T Solution",
"Diorouge Liq",
"Diphen",
"DiphenMax",
"DM Cough and Cold Liquid",
"DM Cough and Cold Liquid",
"DM Cough and Cold Liquid Cherry Flavour",
"DM Cough and Cold Relief",
"DM Cough and Cold Syrup",
"Doc in the Box All Day Supply",
"Doctor Manzanilla Allergy and Decongestant Relief",
"Doctor Manzanilla Cough and Cold",
"Doctor Manzanilla Cough Suppressant and Nasal Decongestant",
"Dollar General",
"Dollar General Effervescent Cold Relief",
"DoloMax Cold Cough",
"DoloMax Cold Cough",
"Dometuss",
"Dometuss-DA",
"Dometuss-dmx",
"Dometuss-G",
"Dometuss-G",
"Dometuss-NR",
"Dometuss-NR",
"Donatuss DC",
"Donatussin",
"Donatussin",
"Donatussin DM Drops DM",
"Donatussin DROPS",
"Dover Coldonyl",
"Dover Sudanyl PE",
"Dover Sudanyl PE",
"Doxylamine Succinate and Phenylephrine Hydrochloride",
"Dr Butlers Hemorrhoid and Fissure PF",
"Dr Cocoa Day Night Combo",
"Dr Cocoa Day Night Combo",
"Dr Manzanilla DM",
"Dr Manzanilla PE",
"Dr. Butler Hemorrhoid Treatment",
"Dr. Butler Hemorrhoid Treatment",
"Dr. Cocoa Daytime Cough and Cold",
"Dr. Cocoa Daytime Cough and Cold",
"Dr. Cocoa for Children Daytime Cough + Cold",
"Dr. Cocoa for Children Nighttime Cough + Cold",
"Dr. Cocoa Mucus Relief",
"Dr. Cocoa Nighttime Cough and Cold",
"Dr. Cocoa Nighttime Cough and Cold",
"DriHist SR",
"Dristan Cold Multisymptom",
"Dristan Extra Strength Caplets",
"Dristan Mentholated Nasal Spray",
"Dristan Nasal Mist",
"Dristan Tablets",
"DrKids Children Multi Symptom Cold and Flu",
"DrKids Childrens Multi Symptom Cold Cough and Congestion DM",
"DrKids Childrens Muti Symptom Cold Flu and Sore Throat Nighttime",
"Drs. pharmacy HEMORRHOIDAL COOLING",
"DRx Choice Childrens Stuffy Nose and Chest Congestion",
"DryMax AF",
"DS Never Cold S",
"DS Never Cold S",
"Duo-Medihaler",
"Duohist DH",
"Duradryl",
"Duravent DM",
"Duravent PE",
"Dye Free Cold and Flu",
"Eb306 Nasal Decongestant",
"Ed A-hist",
"Ed A-hist",
"Ed A-hist",
"Ed A-hist",
"Ed A-hist",
"Ed A-hist",
"Ed A-hist DM",
"Ed Bron Gp",
"Ed Chlorped D",
"Ed-A-hist DM",
"Ed-A-hist DM",
"Effervescent Cold Relief",
"Effervescent Cold Relief",
"Effervescent Cold Relief",
"Effervescent Cold Relief",
"Effervescent Cold Relief",
"Effervescent Cold Relief",
"Effervescent Cold Relief - Orange",
"Effervescent Orange Cold Relief",
"Effervescent Orange Cold Relief",
"Effervescent Orange Cold Relief",
"Effervescent Orange Cold Relief",
"End-A-flu Multi-symptom Severe Cold and Cough Nighttime Formula",
"End-A-flu Multi-symptom Severe Cold and Cough Non Drowsy Daytime Formula",
"EndaCof DH",
"EndaCof DM",
"EndaCof Drops",
"Endacon",
"Endal CD",
"Endal CD",
"Entex Lq",
"Entex LQ",
"Entre-B",
"Ephrine Nose Drops",
"Ephrine Nose Extra Strength",
"Equaline Childrens Cold",
"Equaline Childrens Cold and Cough",
"Equaline Childrens Mucus Relief",
"Equaline Cold and Flu Relief",
"Equaline congestion relief",
"Equaline Daytime and Nighttime Cold",
"Equaline Daytime and Nighttime Cold",
"Equaline Daytime and Nighttime Cold and Flu Relief",
"Equaline Daytime Cold and Flu Fast Relief Nighttime Cold and Flu Fast Relief",
"Equaline Daytime Cold and Flu Fast Relief Nighttime Cold and Flu Fast Relief",
"Equaline Daytime Cold and Flu Relief",
"Equaline Daytime Cold and Flu Relief",
"Equaline Daytime Cold Multi Symptom",
"Equaline Daytime Nighttime Cold and Flu Relief",
"Equaline Daytime Severe Cold and Flu Relief",
"Equaline Daytime Severe Cold Fast Relief Nighttime Cold and Flu Fast Relief",
"Equaline Daytime Severe Cold Fast Relief Nighttime Cold and Flu Fast Relief",
"Equaline Effervescent Cold Relief",
"Equaline Fast Acting",
"Equaline Flu and Severe Cold and Cough",
"Equaline Flu and Severe Cold and Cough",
"Equaline Flu and Sore Throat",
"Equaline hemorrhoial",
"Equaline Hemorrhoidal",
"Equaline Hemorrhoidal",
"Equaline Hemorrhoidal",
"Equaline Hemorrhoidal",
"Equaline Hemorrhoidal",
"Equaline Hemorrhoidal",
"Equaline hemorrhoidal cooling",
"Equaline mucus relief",
"Equaline Mucus Relief",
"Equaline Mucus Relief",
"Equaline Multi Symptom Flu and Severe Cold Daytime",
"Equaline Nasal",
"Equaline Nasal Decongestant PE Non Drowsy Maximum Strength",
"Equaline Night Time Cold and Cough Childrens",
"Equaline nighttime cold multi symptom",
"Equaline Nighttime Severe Cold and Flu",
"Equaline Sinus Congestion and Pain Daytime",
"Equaline Tussin Cough and Cold",
"Equaline Tussin Multi Symptom",
"Equate Childrens Cold and Cough",
"Equate Childrens Multi Symptom Cold",
"Equate Childrens Multi symptom Cold Nighttime",
"Equate Cold and Flu",
"Equate Day time cold and flu multi symptom relief",
"Equate Daytime",
"Equate Daytime Cold and Flu",
"Equate Daytime Cold and Flu",
"Equate Daytime Cold and Flu",
"Equate Daytime Cold and Flu Nighttime Cold and Flu",
"Equate Daytime Nighttime Cold and Flu",
"Equate Daytime Nighttime Cold and Flu",
"Equate DayTime NiteTime",
"Equate Daytime Nitetime",
"Equate Daytime Nitetime",
"Equate Daytime Nitetime",
"Equate Daytime Nitetime",
"Equate DayTime NiteTime Severe",
"Equate DayTime NiteTime Severe",
"Equate DayTime Severe",
"Equate Daytime Severe",
"Equate daytime severe vaporice cold and flu nighttime severe vapor ice cold and flu",
"Equate daytime severe vaporice cold and flu nighttime severe vapor ice cold and flu",
"Equate Daytime Vapor Ice Cold and Flu",
"Equate Effervescent Cold Relief",
"Equate Flu and Severe Cold and Cough",
"Equate Flu and Severe Cold and Cough",
"Equate Flu and Severe Cold and Cough",
"Equate Health Non Drowsy DAY Cold and Flu Plus and NIGHTTIME Cold and Flu Plus",
"Equate Health Non Drowsy DAY Cold and Flu Plus and NIGHTTIME Cold and Flu Plus",
"Equate Health Non Drowsy DAY Cold and Flu Plus and NIGHTTIME Cold and Flu Plus",
"Equate Health Non Drowsy DAY Cold and Flu Plus and NIGHTTIME Cold and Flu Plus",
"Equate Hemorrhodial Suppositories",
"Equate Hemorrhoidal",
"Equate hemorrhoidal",
"Equate Hemorrhoidal",
"Equate Hemorrhoidal",
"Equate Hemorrhoidal",
"Equate Hemorrhoidal",
"Equate Nasal",
"Equate Nasal Decongestant PE Maximum Strength",
"Equate Night Time Cold and Cough Childrens",
"Equate Nighttime Cold and Flu",
"Equate Nighttime Cold and Flu",
"Equate Nighttime Vapor Ice Cold and Flu",
"Equate NiteTime DayTime",
"Equate Nitetime Severe",
"Equate Severe Cold Multi Symptom",
"Equate Sinus Day Time",
"Equate Sinus Night Time",
"Equate Suphedrine PE",
"Equate Tussin CF",
"Equate Vapor Ice Cold and Flu",
"Equate Vapor Ice Cold and Flu",
"Exactuss Total Release",
"Exchange Select Hemorrhoidal",
"Exchange Select Hemorrhoidal",
"Expectorant-decongestant Syrup",
"Extra Fast Coltalin",
"Extra Strength Cold Liquid",
"Extra Strength Cold Medication Day Time Relief",
"Extra Strength Cold Medication Night Time Relief",
"Extra Strength Cold Syrup",
"Extra Strength Contac Cold & Sinus Hot Medicated Drink",
"Extra Strength Contac Cold & Sore Throat",
"Extra Strength Contac Complete Cough, Cold & Flu",
"Extra Strength Contac Plus Cold Nasal Congestion",
"Extra Strength Daytime Cold Relief PE",
"Extra Strength Daytime Flu PE",
"Extra Strength DM Cough and Cold Liquid",
"Extra Strength DM Cough and Cold Syrup",
"Extra Strength Multi-symptom Relief Sugar Free",
"Extra Strength Nasal",
"Extra Strength Neocitran Cold Syrup With Mucus Relief",
"Extra Strength Neocitran Flu Syrup",
"Extra Strength Neocitran Total Symptom Relief - Sugar Free",
"Extra Strength Neocitran Total Syrup",
"Extra Strength Nighttime Cold Relief PE",
"Extra Strength Nighttime Flu PE",
"Extra Strength Pharmacitron",
"Extra Strength Sinus Congestion and Headache Day Time Relief",
"Extra Strength Sinus Relief Nasal Decongestant",
"Extra Strength Total Symptom Relief Sugar-free",
"Extra Strength Tylenol Allergy",
"Extra Strength Tylenol Cold and Flu Daytime",
"Extra Strength Tylenol Cold and Flu Nighttime",
"Extra Strength Tylenol Cold Daytime",
"Extra Strength Tylenol Cold Nighttime",
"Extra Strength Tylenol Flu Daytime",
"Extra Strength Tylenol Flu Nighttime",
"Extra Strength Tylenol Sinus Daytime",
"Extra Strength Tylenol Sinus Nighttime",
"Facol Cold and Flu Day",
"Facol Cold and Flu Day and Night",
"Facol Cold and Flu Night",
"Family Care Childrens Decongestant Nose Drops",
"Family Care Cold and Flu Multi Symptom",
"Family Care Cold and Flu Multi Symptom Relief SGC Daytime",
"Family Care Hemorrhoidal",
"Family Care Hemorrhoidal",
"Family Care Multi Symptom Cold",
"Family Dollar Daytime and Nighttime Combo Pack Cold and Flu",
"Family Dollar Daytime Cold and Flu Relief",
"Family Dollar Multi-Symptom Severe Cold Green Tea and Honey Lemon flavors",
"Family Dollar Nighttime Severe Cold and Cough honey lemon infused with chamomile and white tea flavors",
"Family DollarSevere Nighttime Cold and Flu",
"Family Wellness",
"Family wellness",
"Family Wellness",
"Family Wellness",
"Family Wellness Effervescent Cold Relief Orange",
"Family Wellness Effervescent Cold Relief Original",
"Family Wellness flu and severe cold and cough nighttime",
"Family wellness hemorrhoidal",
"Family Wellness Hemorrhoidal",
"Family Wellness Hemorrhoidal",
"Family Wellness Hemorrhoidal",
"Family Wellness Hemorrhoidal",
"Family Wellness Multi Symptom Severe Cold",
"Family Wellness Severe Cold and Cough",
"Fargelin Hemorrhoidal",
"Fast Acting Cold, Flu and Sore Throat Relief",
"Fast Acting Mucus Relief Maximum Strength Severe Cough and Congestion",
"Fast Cold and Flu Relief",
"Fast Cold and Flu Relief",
"Fast Dissolving Daytime - Nighttime Cold and Flu",
"Fast Dissolving Daytime - Nighttime Cold and Flu",
"Fast Maximum Night Time Cold and Flu",
"Fast Maximum Night Time Cold and Flu",
"Fast Maximum Severe Congestion and Cough",
"Fast Mucus Relief",
"Fast Mucus Relief",
"Fast Mucus Relief",
"Fast Mucus Relief",
"Fast Mucus Relief",
"Fast Mucus Relief Cold Flu and Sore Throat Maximum Strength Multi-Symptom",
"Father Johns Cough Medicine Plus",
"Father Johns Cough Medicine Plus",
"Febrix Kids PLUS",
"Fedrin",
"First Aid Direct Headache and Congestion Sinus Relief",
"First Aid Direct Nasal and Sinus Decongestant",
"First Aid Shot Therapy Cold Relief",
"Fleet",
"FLONASE Headache and Allergy Relief",
"Flu and Severe Cold",
"Flu and Severe Cold",
"Flu and Severe Cold and Cough",
"Flu and Severe Cold and Cough",
"Flu and Severe Cold and Cough",
"Flu and Severe Cold and Cough",
"Flu and Severe Cold and Cough",
"Flu and Severe Cold and Cough",
"Flu and Severe Cold and Cough Daytime",
"Flu and Severe Cold and Cough Daytime",
"Flu and Severe Cold and Cough daytime",
"Flu and Severe Cold and Cough Daytime",
"Flu and Severe Cold and Cough Daytime",
"Flu and Severe Cold and Cough Night Time",
"Flu and Severe Cold and Cough Nighttime",
"Flu and Severe Cold and Cough Nighttime",
"Flu and Severe Cold and Cough Nighttime",
"Flu and Severe Cold and Cough Nighttime",
"Flu and severe cold daytime nighttime",
"Flu and severe cold daytime nighttime",
"Flu and Severe Cold Daytime Relief",
"Flu and Severe Cold Nighttime Relief",
"Flu and Sore Throat",
"Flu and Sore Throat",
"Flu and Sore Throat",
"Flu and Sore Throat",
"Flu and Sore Throat Multi Symptom",
"Flu and Sore Throat Relief",
"Flu and Sore Throat Soothing Warm Relief",
"Flu Multi Symptom Relief",
"Flu Multi Symptom Relief",
"Flu Relief Childrens",
"Flu Relief Cold and Chest Congestion",
"Flu Relief Therapy",
"Flu Relief Therapy",
"Flu Relief Therapy Day Time",
"Flu Relief Therapy Day Time",
"Flu Relief Therapy Day Time",
"Flu Relief Therapy Day Time",
"Flu Relief Therapy Day Time",
"Flu Relief Therapy Day Time",
"Flu Relief Therapy Day Time",
"Flu Relief Therapy Day Time",
"Flu Relief Therapy Day Time",
"Flu Relief Therapy Day Time",
"Flu Relief Therapy Daytime",
"Flu Relief Therapy Daytime",
"Flu Relief Therapy Daytime Severe Cold",
"Flu Relief Therapy Night Time",
"Flu Relief Therapy Night Time",
"Flu Relief Therapy Night Time",
"Flu Relief Therapy Night Time",
"Flu Relief Therapy Night Time",
"Flu Relief Therapy Night Time",
"Flu Relief Therapy Night Time",
"Flu Relief Therapy Night Time",
"Flu Relief Therapy Night Time",
"Flu Relief Therapy Night Time",
"Flu Relief Therapy Night Time",
"Flu Relief Therapy Nighttime",
"Flu Relief Therapy Nighttime",
"Flu Relief Therapy Nighttime",
"Flu Relief Therapy Nighttime",
"Flu Relief Therapy Nighttime Severe Cold",
"Flu Relief Therapy Severe Cough and Cold Nighttime",
"Flu Relief Therapy Severe Cough and Cold Nighttime",
"Flu-away-extra Strength",
"Flu-away-regular Strength",
"FLU-MED DAYTIME SEVERE COLD and COUGH non drowsy formula",
"FLU-MED NIGHTTIME SEVERE COLD and COUGH",
"Flu, Cough and Sore Throat",
"Fluact",
"Formu Care Flu and Severe Cold and Cough Night Time",
"Formulation R",
"Formulation R Hemorrhoidal Ointment",
"Formulation R Hemorrhoidal Suppositories",
"Foster and Thrive Chest Congestion Relief PE PE",
"Foster and Thrive Childrens Cold and Cough Relief DM",
"Foster and Thrive Daytime Severe Cold and Flu Relief",
"Foster and Thrive Nighttime Severe Cold and Flu Relief",
"Freds Hemorrhoidal",
"Fresh Clear",
"Fulton Street Market Cold",
"Fulton Street Market Nighttime Flu and Severe Cold and Cough",
"G-bronco-D",
"G-P-tuss Dxp",
"G-Supress DX",
"G-tron Ped",
"G-tron Pediatric Drops",
"G-tusicof",
"Gencontuss",
"Gilphex",
"Gilphex",
"Gilphex TR",
"Giltuss",
"Giltuss Allergy Plus",
"Giltuss Allergy Plus Cough and Congestion",
"Giltuss Childrens Allergy Plus Cough and Congestion",
"Giltuss Childrens Cough and Cold",
"Giltuss Childrens MultiSymptom Cold and Flu",
"Giltuss Cough and Cold",
"Giltuss Cough and Cold",
"Giltuss D Allergy and Congestion",
"Giltuss MultiSymptom Cold and Flu",
"Giltuss Pediatric",
"Giltuss Sinus and Chest Congestion",
"Giltuss Total Release",
"Giltuss TR",
"Giltuss TR",
"Glen PE",
"Glenmax PEB",
"Glenmax PEB DM",
"Glenmax PEB DM FORTE",
"Glycerin, Lidocaine, Petrolatum, and Phenylephrine Hydrochloride",
"Glycerin, Phenylephrine Hydrochloride, Pramoxine, White Petrolatum",
"GNP Hemorrhoidal",
"GNP Mucus Relief PE",
"Good Neighbor Pharmacy Allergy Multi Symptom",
"Good Neighbor Pharmacy Childrens Mucus Relief",
"Good Neighbor Pharmacy Cleartime",
"Good Neighbor Pharmacy Cold",
"Good Neighbor Pharmacy Cold",
"Good Neighbor Pharmacy Cold",
"Good Neighbor Pharmacy Cold",
"Good Neighbor Pharmacy Cold",
"Good Neighbor Pharmacy Cold",
"Good Neighbor Pharmacy Cold and Allergy Childrens",
"Good Neighbor Pharmacy Cold and Allergy PE",
"Good Neighbor Pharmacy Cold and Cough",
"Good Neighbor Pharmacy Cold and Flu Night Time",
"Good Neighbor Pharmacy Cold Head Congestion",
"Good Neighbor Pharmacy Cold Head Congestion",
"Good Neighbor Pharmacy Cold Multi Symptom",
"Good Neighbor Pharmacy Cold Multi Symptom",
"Good Neighbor Pharmacy Cold Plus Multi Symptom",
"Good Neighbor Pharmacy Cold Severe",
"Good Neighbor Pharmacy Congestion Relief",
"Good Neighbor Pharmacy Day Time",
"Good Neighbor Pharmacy Day Time",
"Good Neighbor Pharmacy Day Time Cold and Flu",
"Good Neighbor Pharmacy Day Time Severe",
"Good Neighbor Pharmacy Dye Free Severe Cold Multi-Symptom",
"Good Neighbor Pharmacy Fast Acting Nasal",
"Good Neighbor Pharmacy Flu and Severe Cold and Cough",
"Good Neighbor Pharmacy Flu and Severe Cold and Cough",
"Good Neighbor Pharmacy Flu and Severe Cold and Cough",
"Good Neighbor Pharmacy Flu and Severe Cold and Cough Nighttime",
"Good Neighbor Pharmacy Flu and Severe Cold Daytime",
"Good Neighbor Pharmacy Flu and Sore throat",
"Good Neighbor Pharmacy Hemorrhoidal",
"Good neighbor pharmacy mucus relief",
"Good Neighbor Pharmacy Mucus Relief cold and sinus",
"Good Neighbor Pharmacy Mucus Relief PE PE",
"Good Neighbor Pharmacy Mucus Relief Severe Cold",
"Good Neighbor Pharmacy Mucus Relief Severe Cold Cold and Flu Night Time",
"Good Neighbor Pharmacy Mucus Relief Severe Cold Cold and Flu Night Time",
"Good Neighbor Pharmacy Mucus Relief Severe Congestion and Cold",
"Good Neighbor Pharmacy Nasal Decongestant PE Non Drowsy",
"Good Neighbor Pharmacy Nasal Four",
"Good Neighbor Pharmacy Night Time",
"Good Neighbor Pharmacy Night Time Severe",
"Good Neighbor Pharmacy Nose",
"Good Neighbor Pharmacy Severe Cold",
"Good Neighbor Pharmacy Severe Day Time",
"Good Neighbor pharmacy severe night time",
"Good Neighbor Pharmacy Severe Night Time",
"Good Neighbor Pharmacy Severe Sinus Congestion",
"Good Neighbor Pharmacy Sinus",
"Good Neighbor Pharmacy Sinus",
"Good Neighbor Pharmacy Sinus and Allergy PE",
"Good Neighbor Pharmacy Sinus Congestion and Pain",
"Good Neighbor Pharmacy Sinus Congestion and Pain",
"Good Neighbor Pharmacy Sinus Relief",
"Good Neighbor Pharmacy Sinus Relief",
"Good Neighbor Pharmacy Sinus Relief Day Time Night Time",
"Good Neighbor Pharmacy Sinus Relief Day Time Night Time",
"Good Neighbor Pharmacy Tussin CF",
"Good Neighbor Pharmacy Tussin CF Max",
"good neighbor pharmacy tussin CF Max",
"Good Sense Allergy Multi Symptom",
"Good Sense Childrens Cold and Allergy",
"Good Sense Childrens Cold and Cough",
"Good Sense Childrens Cold and Cough",
"Good Sense Childrens Cold and Cough",
"Good Sense Childrens Mucus Relief",
"Good Sense Cold",
"Good Sense Cold",
"Good Sense Cold",
"Good Sense Cold and Allergy",
"Good Sense Cold and Flu Severe",
"Good Sense Cold Head Congestion",
"Good Sense Cold Head Congestion Severe",
"Good Sense Cold Max",
"Good Sense cold multi symptom",
"Good Sense cold multi symptom",
"Good Sense Day Time Cold and Flu",
"Good Sense Day Time Night Time Cold and Flu",
"Good Sense Day Time Night Time Cold and Flu",
"Good Sense Daytime",
"good sense DayTime Night Time",
"Good Sense Daytime non drowsy cold and flu",
"Good Sense Effervescent Cold Relief",
"Good Sense Effervescent Cold Relief",
"Good Sense Flu and Severe Cold and Cough",
"Good Sense Flu and Severe Cold and Cough Daytime",
"Good Sense Flu and Severe Cold and Cough Nighttime",
"Good Sense Flu and Sore Throat",
"Good Sense Hemorrhoidal",
"Good Sense hemorrhoidal",
"Good Sense Hemorrhoidal",
"Good Sense Hemorrhoidal",
"Good Sense Hemorrhoidal",
"Good Sense Hemorrhoidal",
"Good Sense Hemorrhoidal Maximum Strength Pain Relief",
"Good Sense Mucus Relief Cold and Sinus",
"Good Sense Mucus Relief cold flu and sore throat",
"Good Sense Mucus Relief Cold Flu and Sore Throat",
"Good Sense Mucus Relief Severe Congestion and Cold",
"Good Sense Multi Symptom Flu and Severe Cold",
"Good Sense Nasal Decongestant PE",
"Good Sense Nasal Decongestant PE",
"Good Sense Nasal Four",
"Good Sense Night Time Cold and Flu",
"Good Sense NightTime DayTime Cold and Flu",
"Good Sense Severe Cold",
"Good Sense Severe Day Time Cold and Flu",
"Good Sense Severe Daytime Cold and Flu",
"Good Sense Severe Daytime Cold and Flu",
"Good Sense Severe Daytime Cold and Flu Severe Nighttime Cold and Flu",
"Good Sense Severe Daytime Cold and Flu Severe Nighttime Cold and Flu",
"Good Sense Severe NightTime",
"Good Sense Severe NightTime Cold and Flu",
"Good Sense Severe Sinus Congestion",
"Good Sense Severe Tussin CF Max",
"Good Sense Sinus and Allergy PE",
"Good Sense Sinus Congestion and Pain",
"Good Sense Sinus plus Headache",
"Good Sense Sinus Relief",
"Good Sense Tussin CF",
"Good Sense Tussin CF",
"Good Sense Tussin CF Cough and Cold",
"Good Sense Tussin CF Cough and Cold",
"Good Sense Tussin CF Max",
"Good Sense Tussin CF Max",
"Goyescas 7 Syrups Alcohol and Sugar Free Cough and Cold",
"Goyescas 7 Syrups Original Cough and Cold",
"Goyescas 7 Syrups with Bee Honey Cough and Cold",
"Goyescas Broncovac 1 Cough and Cold",
"Goyescas Broncovac 2 Cough and Cold",
"Goyescas Broncovac 3 Cough and Cold",
"Green Guard Advanced Sinus Relief",
"Green Guard Advanced Sinus Relief",
"Green Guard Allergy 2 Relief",
"Green Guard Allergy 2 Relief",
"Green Guard Cough and Cold Relief",
"Green Guard Cough and Cold Relief",
"Grippe Extra Fort Jour",
"Grippe Extra Fort Nuit",
"guaifenesin and phenylephrine hydrochloride Sustained-Release",
"Guaifenesin Phenylephrine Dextromethorphan",
"Guaifenesin, Phenylephrine Hydrochloride",
"Guiatex PE",
"H E B MAX SEVERE CONGESTION and COUGH Maxium Strength",
"Handy Solutions Cold Relief",
"Handy Solutions Cold Relief",
"Handy Solutions Sinus Congestion and Pain Relief",
"Harmon Face Values Tussin CF",
"Harris Teeter Day Time",
"Harris Teeter DayTime",
"Harris Teeter DayTime NightTime",
"Harris Teeter DayTime NightTime",
"Harris Teeter Hemorrhoidal",
"Harris Teeter Sinus Relief",
"Harris Teeter Sinus Relief",
"Harris Teeter Sinus Relief",
"Harris Teeter Sinus Relief",
"Harris Teeter Tussin",
"Head and Cold",
"Head Congestion",
"Head Congestion",
"Head Congestion",
"Head Congestion and Cold Relief Daytime",
"Head Congestion and Flu Severe",
"Head Congestion and Flu Severe Relief",
"Head Congestion and Mucus",
"Head Congestion and Mucus",
"Head Congestion Cold Relief",
"Head Congestion Cold Relief",
"Head Congestion Cold Relief Severe Non-Drowsy",
"Head Congestion Daytime and Nighttime Cold",
"Head Congestion Daytime and Nighttime Cold",
"Head Congestion Flu Severe PE",
"Head Congestion Flu Severe PE",
"Head Congestion Mucus PE",
"Head Congestion Mucus PE",
"Head Congestion plus Flu Severe",
"Head Congestion plus Flu Severe",
"Head Congestion plus Flu Severe PE",
"head congestion plus flu severe PE",
"Head Congestion Plus Flu Severe PE",
"Head Congestion plus Flu Severe PE",
"Head Congestion plus Flu Severe PE",
"Head Congestion plus Flu Severe PE",
"Head Congestion Plus Mucus PE",
"head congestion plus mucus PE",
"Head Congestion plus Mucus PE",
"Head Congestion plus Mucus PE",
"Health Mart Adult Tussin",
"Health Mart Childrens Allergy Plus Congestion",
"Health Mart Childrens Cold and Flu",
"Health Mart Cold and Allergy Childrens",
"Health Mart Cold and Cough childrens",
"Health Mart Day Time Cold and Flu Night Time Cold and Flu",
"Health Mart Daytime",
"Health Mart daytime",
"Health Mart Daytime",
"Health Mart Hemorrhoidal",
"Health Mart Nasal Decongestant PE",
"Health Mart Nose",
"Health Mart Severe Cold and Flu",
"Health Mart Severe Cold Cough and Flu",
"Health Mart severe cold cough and flu",
"HealthMart Mucus Relief FM",
"HealthMart Mucus Relief FM",
"HealthMart Mucus Relief FM",
"Healthy Accents Allergy Multi Symptom",
"Healthy Accents Childrens Cold and Cough",
"Healthy Accents Childrens Multi Symptom Fever and Cold",
"Healthy Accents Cleartime",
"Healthy Accents Cold",
"Healthy Accents Cold",
"Healthy Accents Cold and Allergy Childrens",
"healthy accents cold and cough DM",
"Healthy Accents Cold and Flu",
"Healthy Accents Cold Head Congestion",
"Healthy Accents Cold Head Congestion",
"Healthy Accents cold head congestion daytime non drowsy",
"Healthy Accents Congestion Relief",
"Healthy Accents Day Time Night Time",
"Healthy Accents Daytime",
"Healthy Accents Daytime",
"Healthy Accents Daytime Cold and Flu",
"Healthy Accents Daytime Nighttime Cold and Flu",
"Healthy Accents Daytime Nighttime Cold and Flu",
"Healthy Accents Daytime Nighttime Cold and Flu",
"Healthy Accents hemorrhoidal",
"Healthy Accents Hemorrhoidal",
"Healthy Accents hemorrhoidal",
"Healthy accents hemorrhoidal",
"Healthy Accents Hemorrhoidal",
"Healthy Accents Hemorrhoidal",
"Healthy Accents Mucus Relief cold and sinus",
"Healthy Accents Mucus Relief cold flu and sore throat",
"Healthy Accents Mucus Relief Severe Cold",
"Healthy Accents Mucus Relief Severe Congestion and Cold",
"Healthy Accents Multi Symptom Cold",
"Healthy Accents Nasal",
"Healthy Accents Nasal Decongestant Maximum Strength",
"Healthy Accents Severe Cold",
"Healthy Accents Severe Cold Daytime",
"Healthy Accents Sinus",
"Healthy Accents Sinus",
"Healthy Accents Sinus Congestion and Pain Day Time",
"Healthy Accents Sinus Day Time",
"Healthy Accents Sinus Relief",
"Healthy Accents Sinus Relief",
"Healthy Accents Sinus Relief",
"Healthy Accents Tussin CF",
"HEB DayTime Flu And Severe Cold And Cough",
"HEB Hemorrhoidal",
"HEB HEMORRHOIDAL COOLING Gel",
"HEB Maximum Strength Pain Relief Hemorrhoidal",
"Heb Nasal",
"Help I Have a Stuffy Nose",
"Help I Have a Stuffy Nose",
"Help I Have the Sniffles",
"Help I Have the Sniffles",
"Hem Rid",
"HemAway",
"HemAway",
"Hemorrhoid and Fissure Dr. Butler",
"Hemorrhoid and Fissure Dr. Butler",
"Hemorrhoid Anesthetic",
"Hemorrhoid Anesthetic",
"Hemorrhoid Anesthetic",
"Hemorrhoid Master",
"Hemorrhoid Relief",
"Hemorrhoid Relief",
"Hemorrhoid Relief",
"Hemorrhoid Relief",
"Hemorrhoidal",
"Hemorrhoidal",
"Hemorrhoidal",
"Hemorrhoidal",
"Hemorrhoidal",
"Hemorrhoidal",
"Hemorrhoidal",
"Hemorrhoidal",
"Hemorrhoidal",
"Hemorrhoidal",
"Hemorrhoidal",
"Hemorrhoidal",
"Hemorrhoidal",
"Hemorrhoidal",
"Hemorrhoidal",
"Hemorrhoidal",
"Hemorrhoidal",
"Hemorrhoidal",
"Hemorrhoidal",
"Hemorrhoidal",
"Hemorrhoidal",
"Hemorrhoidal",
"Hemorrhoidal",
"Hemorrhoidal",
"Hemorrhoidal",
"Hemorrhoidal",
"Hemorrhoidal",
"Hemorrhoidal",
"Hemorrhoidal",
"Hemorrhoidal",
"Hemorrhoidal",
"Hemorrhoidal",
"Hemorrhoidal",
"Hemorrhoidal",
"Hemorrhoidal",
"Hemorrhoidal",
"Hemorrhoidal",
"Hemorrhoidal",
"Hemorrhoidal",
"Hemorrhoidal",
"Hemorrhoidal",
"Hemorrhoidal",
"Hemorrhoidal",
"Hemorrhoidal",
"Hemorrhoidal",
"Hemorrhoidal",
"Hemorrhoidal",
"Hemorrhoidal",
"Hemorrhoidal",
"Hemorrhoidal",
"Hemorrhoidal",
"Hemorrhoidal",
"Hemorrhoidal",
"Hemorrhoidal",
"Hemorrhoidal",
"Hemorrhoidal",
"Hemorrhoidal",
"Hemorrhoidal",
"Hemorrhoidal",
"Hemorrhoidal",
"Hemorrhoidal",
"Hemorrhoidal",
"Hemorrhoidal",
"Hemorrhoidal",
"Hemorrhoidal",
"Hemorrhoidal",
"Hemorrhoidal",
"Hemorrhoidal",
"Hemorrhoidal",
"Hemorrhoidal",
"Hemorrhoidal",
"Hemorrhoidal",
"Hemorrhoidal",
"Hemorrhoidal",
"Hemorrhoidal",
"Hemorrhoidal",
"Hemorrhoidal",
"Hemorrhoidal",
"Hemorrhoidal",
"Hemorrhoidal",
"Hemorrhoidal Anesthetic",
"Hemorrhoidal cocoa butter",
"Hemorrhoidal Cooling",
"Hemorrhoidal Cooling",
"Hemorrhoidal cooling",
"Hemorrhoidal Cooling",
"Hemorrhoidal Cooling Gel",
"Hemorrhoidal Cooling Gel",
"Hemorrhoidal Cooling Gel",
"Hemorrhoidal Cream",
"Hemorrhoidal Cream",
"Hemorrhoidal Cream",
"Hemorrhoidal Cream",
"Hemorrhoidal Cream with Aloe",
"Hemorrhoidal Maximum Strength Pain Relief",
"Hemorrhoidal Ointment",
"Hemorrhoidal Ointment",
"Hemorrhoidal Pain Relief",
"Hemorrhoidal Rectal",
"Hemorrhoidal Relief",
"Hemorrhoidal Relief",
"Hemorrhoidal Relief",
"Hemorrhoidal Relief",
"Hemorrhoidal Relief",
"Hemorrhoidal Relief Cream",
"Hemorrhoidal Relief Cream",
"Hemorrhoidal Relief Cream",
"Hemorrhoidal Relief Ointment",
"Hemorrhoidal Soothing Well at Walgreens",
"Hemorrhoidal Suppositories",
"Hemorrhoidal Suppositories",
"Hemorrhoidal Suppositories",
"Hemorrhoidal Suppositories",
"Hemorrhoidal With Lidocaine",
"Hemorrhoidal-Ointment",
"HEMORRHOIDALCREAMPro",
"Hemorrhoidalcreamprocure",
"HemorrhoidalOintment",
"HemorrhoidalOintment",
"HemorrhoidalOintment",
"HemorrhoidalOintment",
"HemorrhoidalOintment",
"Hemorrodil",
"Hemorroidal Cooling gel",
"Hemorroidal Cooling gel",
"Hemorroidal Cooling gel",
"Histenol Forte II",
"Histenol Forte II",
"Histenol II",
"Histex Ac",
"Histex-DM",
"Histex-PE",
"Hot Lemon Cold & Sore Throat Night",
"Hot Lemon Cold and Flu Relief Extra Strength",
"Hot Lemon Cold and Flu Relief Regular Strength",
"Hot Lemon Cold and Flu Relief Regular Strength",
"Hot Lemon Cold and Flu Relief Super Strength",
"Hot Lemon Cough and Cold Relief DM",
"Hot Lemon Cough and Colds Relief DM",
"Hot Lemon Extra Strength",
"Hot Lemon Extra Strength Cold & Congestion",
"Hot Lemon Extra Strength Cold & Sinus Night",
"Hot Lemon Extra Strength Total Cold Night",
"Hot Lemon for Colds Powder",
"Hot Lemon Regular - Pwr",
"Hot Lemon Relief - Extra Strength",
"Hot Lemon Relief Extra Strength",
"Hot Lemon Relief for Cold Symptoms Ext Str",
"Hot Lemon Relief for Cold Symptoms Pws",
"Hot Lemon Relief for Symptoms Of Cold and Flu",
"Hot Lemon Relief for Symptoms Of Cold and Flu Extra Strength",
"Hot Lemon Relief for Symptoms Of Cold and Flu Forte",
"Hot Lemon Relief for Symptoms Of Cold and Flu Regular Strength",
"Hot Lemon Relief for Symptoms Of Cough and Cold",
"Hot Lemon Relief Pck-pws",
"Hot Lemon Relief Powder",
"Hot Lemon Relief Powder Extra Strength",
"Hot Lemon Relief Powder Extra Strength",
"Hot Lemon Relief Powder Regular Strength",
"Hot Lemon Relief Regular Strength",
"Hot Lemon Relief Regular Strength",
"Hot Lemon Relief-extra Strength Pck-pws",
"Hot Lemon Total Cold Extra Strength",
"Hot Liquid Relief for Symptoms Of Cold and Cough",
"Hot Liquid Relief for Symptoms Of Flu and Sore Throat",
"Humana Pharmacy Daytime Cold and Flu Relief",
"Humana Pharmacy Hemorrhoidal",
"Humana Pharmacy Nasal Decongestant PE",
"Humana Pharmacy Sinus Relief",
"Humana Pharmacy Tussin Multi Symptom Cold",
"hybrid CF",
"Hycomine",
"Hycomine-S",
"HyVee Health Effervescent Cold Relief",
"Igualtuss",
"Immphentiv",
"Immphentiv",
"J-max",
"Jack & Jill Bedtime Cough & Cold",
"Jack & Jill Bedtime Multi-symptom Cold & Cough",
"Jack & Jill Complete",
"Jack & Jill Cough & Cold",
"Junior Strength Tylenol Cold and Cough",
"Kids Cold Chewable Tablets",
"Kids-EEZE Cough and Cold",
"Kirkland Signature Cold",
"Klernaz",
"KMart - Fast Maximum Cold and Sinus",
"KMart - Fast Maximum Cold, Flu and Sore Throat Relief",
"KMart - Fast Maximum Severe Congestion and Cough",
"Kroger Cough Cold and Flu",
"Kroger Daytime and Nighttime Cold and Flu Softgel",
"Kroger Daytime Cold and Flu Softgel",
"Kroger DayTime Flu plus Severe Cold and Cough",
"Kroger Effervescent Cold Relief",
"Kroger Maximum Strength Severe Congestion and Cough",
"Kroger NiteTime Cold and Flu",
"Kroger NiteTime Flu plus Severe Cold and Cough",
"Kroger Sinus Pain and Pressure",
"L-Oral COLD AND FLU RELIEF Syrup",
"Leader",
"Leader",
"Leader Allergy Multi Symptom",
"LEADER Chest Congestion Relief PE",
"Leader Childrens Cold and Allergy",
"Leader Childrens Cold and Allergy",
"Leader Childrens Cold and Cough",
"Leader Childrens Cold and Cough",
"Leader Childrens Mucus Relief",
"Leader Childrens Mucus Relief Multi Symptom Cold",
"Leader Childrens Multi Symptom Cold",
"Leader Cold and Allergy",
"Leader Cold and Flu",
"Leader Cold and Flu",
"Leader Cold Head Congestion",
"Leader Cold Head Congestion",
"Leader Cold Head Congestion",
"Leader Cold Relief",
"Leader Congestion Relief",
"Leader Day Time",
"Leader Day Time",
"Leader Day Time",
"Leader Day time Cough and Cold Childrens",
"Leader Day Time Multi Symptom Cold Flu Relief",
"Leader Daytime Cold and Flu",
"Leader Daytime Severe Cold and Flu",
"Leader Daytime Severe Cold and Flu Relief",
"Leader Flu and Severe Cold and Cough",
"Leader Flu and Severe Cold and Cough",
"Leader Flu and Severe Cold and Cough",
"Leader Flu and Severe Cold and Cough",
"Leader Flu and Severe Cold and Cough",
"Leader Hemorrhoidal",
"Leader Hemorrhoidal",
"Leader Hemorrhoidal",
"Leader Hemorrhoidal",
"Leader Hemorrholidal",
"Leader Mucus Relief",
"Leader mucus relief cold and sinus",
"Leader Mucus Relief Cold and Sinus",
"Leader Mucus Relief Cold Flu and Sore Throat",
"Leader Mucus Relief Cold Flu and Sore Throat",
"Leader Mucus Relief Sever Cold",
"Leader Mucus Relief Severe Congestion and Cold",
"Leader multi symptom flu and severe cold",
"Leader Nasal Decongestant PE",
"Leader Nasal Decongestant PE Maximum Strength",
"Leader Night Time Cough and Cold Childrens Triacting",
"Leader Nighttime Sever Cold and Flu",
"Leader Nighttime Severe Cold and Flu",
"Leader Nite Time Severe Cold and Flu",
"Leader Nose",
"Leader Severe Cold and Cough",
"Leader Severe Cold and Flu",
"Leader severe cold and flu",
"Leader Severe Sinus Congestion",
"Leader Sinus and Allergy PE",
"Leader Sinus Congestion and Pain Daytime Non Drowsy",
"Leader sinus relief",
"Leader Sinus Relief",
"Leader Sinus Relief",
"Leader Sinus Relief",
"Leader Tussin",
"Leader Tussin",
"Leader Tussin CF",
"Leader Tussin CF",
"Leader Tussin CF",
"Leader Tussin CF Max",
"Lemon Time",
"LIDL Daytime Cold and Flu Relief Multi Symptom",
"Lidocaine",
"Lidocaine",
"lidoForte Hemorrhoidal",
"Lil Drug Store Allergy Sinus Relief",
"Lil Drug Store Allergy Sinus Relief",
"Lil Drug Store Cold Relief",
"Lil Drug Store Cold Relief",
"Lil Drug Store Multi-Symptom Sinus Relief",
"Lil Drug Store Multi-Symptom Sinus Relief",
"Lil Drug Store Multi-Symptom Sinus Severe Congestion",
"Lil Drug Store NyQuil Severe Cold and Flu, Max Strength",
"Lil Drug Store Tylenol Cold plus Flu Severe",
"Lil Drug Store Tylenol Sinus Severe",
"Liquibid D-R",
"Liquibid PD-R",
"Little Colds Decongestant Plus Cough",
"Little Colds Decongestant Plus Cough",
"Little Colds Multi Symptom Cold",
"Little Colds Multi Symptom Cold plus Fever",
"Little Colds Multi-symptom Cold Formula",
"Little Noses Decongestant Nose Drops",
"Little Noses Decongestant Nose Drops",
"Little Remedies Decongestant Nasal Drops",
"Little Remedies Decongestant Nose Drops",
"LoHist",
"LoHist DM",
"LoHist PEB",
"LoHist PEB DM",
"Lucky SuperSoft",
"Lucky SuperSoft Hemorrhoidal",
"Lusair",
"M-end PE",
"M-Hist DM",
"Major Prep Hemorrhoidal",
"Major Prep Hemorrhoidal",
"Major Prep Hemorrhoidal",
"Major Prep Hemorrhoidal",
"Makesense",
"Mapap Sinus Congestion and Pain Maximum Strength",
"Mapap Sinus Congestion and Pain Maximum Strength",
"MAX Cold, Flu, and Sore Throat",
"Maxi-Tuss CD",
"Maxi-Tuss Jr",
"Maxi-Tuss PE",
"Maxi-Tuss PE Jr",
"Maxi-Tuss PE Max",
"Maxichlor PEH DM",
"Maximum Allergy Relief",
"Maximum Strenght Day Cold and Flu Formula",
"Maximum Strength Cold and Flu",
"Maximum Strength Cold and Flu",
"Maximum Strength Cold and Flu",
"Maximum Strength Cold and Flu",
"Maximum Strength Cold Flu and Sore Throat",
"Maximum Strength Cold Flu and Sore Throat",
"Maximum Strength Cold, Flu and Sore Throat",
"Maximum Strength Cold, Flu and Sore Throat",
"Maximum Strength Congestion and Headache",
"Maximum Strength Congestion and Headache",
"Maximum Strength Congestion and Headache",
"Maximum Strength Day-night Cold and Flu Formula",
"Maximum Strength Day-night Cold and Flu Formula",
"Maximum Strength Daytime - Nighttime Cold and Flu Cold and Flu",
"Maximum Strength Daytime - Nighttime Cold and Flu Cold and Flu",
"Maximum Strength Daytime Cold/Flu Relief",
"Maximum Strength Daytime Nighttime Cold and Flu",
"Maximum Strength Daytime Nighttime Cold and Flu",
"Maximum Strength Daytime Nighttime Sinus Relief",
"Maximum Strength Daytime Nighttime Sinus Relief",
"Maximum Strength Daytime Non Drowsy Severe Cold and Flu",
"Maximum Strength Mucinex Fast-Max Cold and Flu",
"Maximum Strength Mucinex Fast-Max Cold and Flu",
"Maximum Strength Mucinex Fast-Max Cold and Flu",
"Maximum Strength Mucinex Fast-Max Cold and Flu",
"Maximum Strength Mucinex Fast-Max Cold and Flu and Mucinex NightShift Severe Cold and Flu",
"Maximum Strength Mucinex Fast-Max Cold and Flu and Mucinex NightShift Severe Cold and Flu",
"Maximum Strength Mucinex Fast-Max Cold and Flu and Mucinex NightShift Severe Cold and Flu",
"Maximum Strength Mucinex Fast-Max Cold and Flu and Mucinex NightShift Severe Cold and Flu",
"Maximum Strength Mucinex Fast-Max Day Cold and Flu and Night Cold and Flu",
"Maximum Strength Mucinex Fast-Max Day Cold and Flu and Night Cold and Flu",
"Maximum Strength Mucinex Fast-Max Day Time Cold and Flu and Maximum Strength Mucinex Fast-Max Night Time Cold and Flu",
"Maximum Strength Mucinex Fast-Max Day Time Cold and Flu and Maximum Strength Mucinex Fast-Max Night Time Cold and Flu",
"Maximum Strength Mucinex Fast-Max Day Time Cold and Flu and Night Time Cold and Flu",
"Maximum Strength Mucinex Fast-Max Day Time Cold and Flu and Night Time Cold and Flu",
"Maximum Strength Mucinex Fast-Max Night Time Cold and Flu",
"Maximum Strength Mucinex Sinus-Max Pressure, Pain and Cough",
"Maximum Strength Mucinex Sinus-Max Severe Congestion and Pain",
"Maximum Strength Mucinex Sinus-Max Severe Congestion and Pain",
"Maximum Strength Mucinex Sinus-Max Severe Congestion and Pain and Mucinex Nightshift Sinus",
"Maximum Strength Mucinex Sinus-Max Severe Congestion and Pain and Mucinex Nightshift Sinus",
"Maximum Strength Mucinex Sinus-Max Severe Congestion and Pain Clear and Cool",
"Maximum Strength Mucus Relief Cold Flu and Sore Throat",
"Maximum Strength Mucus Relief Cold,Flu and Sore Throat",
"Maximum Strength Mucus Relief Cold,Flu and Sore Throat",
"Maximum Strength Mucus Relief Severe Congestion and Cough",
"Maximum Strength Mucus Relief Severe Congestion and Cough",
"Maximum Strength Mucus Relief Severe Congestion and Cough",
"Maximum Strength Mucus Relief Severe Congestion and Cough",
"Maximum Strength Mucus Relief Severe Congestion and Cough Cooling Menthol",
"Maximum Strength Nasal Decongestant",
"Maximum Strength Nasal Decongestant",
"Maximum Strength Night Time Cold and Flu Relief",
"Maximum Strength Nighttime Cold and Flu",
"Maximum Strength Nighttime Cold and Flu",
"Maximum Strength Nighttime Cold and Flu",
"Maximum Strength Nighttime Cold/Flu Relief",
"Maximum Strength Nighttime Cold/Flu Relief",
"Maximum Strength Nighttime Sever Cold and Flu",
"Maximum Strength Non Drowsy Day and Night Cold and Flu",
"Maximum Strength Non Drowsy Day and Night Cold and Flu",
"Maximum Strength Non Drowsy Daytime Severe Cold and Flu",
"Maximum Strength Non Drowsy Daytime Severe Cold and Flu",
"Maximum Strength Severe Congestion and Cough",
"Maximum Strength Severe Congestion Relief",
"Maximum Strength Severe Congestion Relief",
"Maximum Strength Severe Sinus Pressure, Pain and Cough Relief",
"Maximum Strenth Night Cold and Flu Formula",
"Maxiphen",
"Maxiphen DM",
"MAXIUM STRENGTH SEVERE CONGESTION and COUGH MAX",
"Mayinglong Bezornil Hemorrhoidal",
"McKesson Phenylephrine HCl",
"McKesson Sinus Pain and Pressure Relief",
"Medi First Plus Sinus Pain and Pressure",
"Medi First Plus Sinus Pain and Pressure",
"Medi First Sinus Pain and Pressure",
"Medi First Sinus Pain and Pressure",
"Medi-First Cold Relief",
"Medi-First Cold Relief",
"Medi-First Cough Cold",
"Medi-First Plus Cold Relief",
"Medi-First Plus Cold Relief",
"Medi-First Plus Cough Cold",
"Medi-First Plus Sinus Decongestant",
"Medi-First Plus Sinus Decongestant",
"Medi-First Sinus Decongestant",
"Medi-First Sinus Decongestant",
"Medicated Hemorrhoidal CVS",
"MediGummies Allergy and Sinus",
"MediGummies Cold and Sinus",
"Medique at Home Cold Relief",
"Medique at Home Decorel Forte",
"Medique CCP Caffeine Free",
"Medique CCP Caffeine Free",
"Medique CCP Caffeine Free",
"Medique Cold Cough Product",
"Medique Decorel Forte",
"Medique Decorel Forte Plus",
"Medique Decorel Forte Plus",
"Medique Medi-Phenyl",
"Medique Medi-Phenyl",
"Medique Medicidin D",
"Medique Medicidin D",
"Medique Onset Forte",
"Meds on the Go",
"Meijer Adult Severe Multi-Symptom Cough Cold Flu",
"meijer Daytime and Nighttime Cold and Flu SOFTGEL",
"Meijer Daytime Severe Cold and Cough Berry infused with Menthol and Green Tea flavors",
"Meijer Effervescent Cold Relief",
"Meijer Maximum Strength Severe Congestion and Cough",
"Meijer Multi-Symptom Severe Cold Green Tea and Honey Lemon flavors",
"Meijer Nighttime Severe Cold and Cough Honey Lemon infused with Chamomile and White Tea Flavors",
"Members Mark Allergy",
"Miclara DM",
"Mineral Oil, Petrolatum and Phenylephrine HCl",
"Mineral Oil, Petrolatum, Phenylephrine Hydrochloride, Shark Liver Oil",
"Minims Phenylephrine Hydrochloride",
"Minims Phenylephrine Hydrochloride",
"Mintuss DR",
"Moore Medical MooreBrand Severe Cold Relief",
"Moore Medical MooreBrand Severe Cold Relief",
"Moore Medical Sinus Pain and Pressure Relief",
"Moore Medical Sinus Pain and Pressure Relief",
"MooreBrand Phenylephrine",
"MooreBrand Phenylephrine",
"MucaphEd",
"Mucinar Kids PLUS",
"Mucinar PLUS",
"Mucinar PLUS",
"Mucinex Childrens Cold and Flu",
"Mucinex Childrens Cough and Congestion",
"Mucinex Childrens Cough and Congestion",
"Mucinex Childrens Day Time Multi-Symptom Cold and Mucinex Childrens Night Time Multi-Symptom Cold Triple Pack",
"Mucinex Childrens Day Time Multi-Symptom Cold and Mucinex Childrens Night Time Multi-Symptom Cold Triple Pack",
"Mucinex Childrens Day Time Multi-Symptom Cold and Night Time Multi-Symptom Cold",
"Mucinex Childrens Day Time Multi-Symptom Cold and Night Time Multi-Symptom Cold",
"Mucinex Childrens FreeFrom Multi-Symptom Cold and Flu Nighttime",
"Mucinex Childrens FreeFrom Multi-Symptom Cold and Stuffy Nose",
"Mucinex Childrens FreeFrom Multi-Symptom Cold, Flu and Sore Throat",
"Mucinex Childrens FreeFrom Multi-Symptom Cold, Flu and Sore Throat and Mucinex Childrens FreeFrom Multi-Symptom Cold and Flu Nighttime",
"Mucinex Childrens FreeFrom Multi-Symptom Cold, Flu and Sore Throat and Mucinex Childrens FreeFrom Multi-Symptom Cold and Flu Nighttime",
"Mucinex Childrens FreeFrom Multi-Symptom Cold, Flu and Sore Throat and Mucinex Childrens FreeFrom Multi-Symptom Cold and Flu Nighttime",
"Mucinex Childrens FreeFrom Multi-Symptom Cold, Flu and Sore Throat and Mucinex Childrens FreeFrom Multi-Symptom Cold and Flu Nighttime",
"Mucinex Childrens Multi-Symptom Cold",
"Mucinex Childrens Multi-Symptom Cold and Sore Throat",
"Mucinex Childrens Multi-Symptom Cough, Cold and Fever",
"Mucinex Childrens Night Time Multi-Symptom Cold",
"Mucinex Childrens Stuffy Nose and Chest Congestion",
"Mucinex Fast Max Day Time Severe Congestion and Cough and Night Time Cold and Flu",
"Mucinex Fast Max Day Time Severe Congestion and Cough and Night Time Cold and Flu",
"MUCINEX FAST MAX Liquid Cold and Flu Kickstart and MUCINEX Nightshift Kickstart",
"MUCINEX FAST MAX Liquid Cold and Flu Kickstart and MUCINEX Nightshift Kickstart",
"Mucinex Fast-Max Cold and Flu",
"Mucinex Fast-Max Cold and Flu and Mucinex NightShift Cold and Flu",
"Mucinex Fast-Max Cold and Flu Arctic Burst and Nightshift Severe Cold and Flu Arctic Burst",
"Mucinex Fast-Max Cold and Flu Arctic Burst and Nightshift Severe Cold and Flu Arctic Burst",
"Mucinex Fast-Max Cold and Flu Arctic Burst Maximum Strength",
"Mucinex Fast-Max Cold and Flu Maximum Strength",
"Mucinex Fast-Max Cold and Sinus",
"Mucinex Fast-Max Cold and Sinus",
"Mucinex Fast-Max Cold, Flu and Sore Throat",
"Mucinex Fast-Max Cold, Flu and Sore Throat",
"Mucinex Fast-Max Cold, Flu and Sore Throat",
"Mucinex Fast-Max Cold, Flu and Sore Throat",
"Mucinex Fast-Max Cold, Flu and Sore Throat",
"Mucinex Fast-Max Cold, Flu and Sore Throat",
"Mucinex Fast-Max Cold, Flu and Sore Throat and Mucinex NightShift Cold and Flu",
"Mucinex Fast-Max Cold, Flu and Sore Throat Clear and Cool",
"Mucinex Fast-Max Cold, Flu and Sore Throat Maximum Strength",
"Mucinex Fast-Max Congestion and Headache",
"Mucinex Fast-Max Congestion and Headache",
"Mucinex Fast-Max Congestion and Headache",
"Mucinex Fast-Max Congestion and Headache",
"Mucinex Fast-Max Congestion and Headache Clear and Cool",
"Mucinex Fast-Max Congestion and Headache Maximum Strength",
"Mucinex Fast-Max Day Cold and Flu and Mucinex Nightshift Night Severe Cold and Flu Maximum Strength",
"Mucinex Fast-Max Day Cold and Flu and Mucinex Nightshift Night Severe Cold and Flu Maximum Strength",
"Mucinex Fast-Max Day Cold and Flu and Night Cold and Flu Maximum Strength",
"Mucinex Fast-Max Day Cold and Flu and Night Cold and Flu Maximum Strength",
"Mucinex Fast-Max Day Cold and Flu and Night Cold and Flu Maximum Strength",
"Mucinex Fast-Max Day Cold and Flu and Night Cold and Flu Maximum Strength",
"Mucinex Fast-Max Day Severe Cold and Night Cold and Flu",
"Mucinex Fast-Max Day Severe Cold and Night Cold and Flu",
"Mucinex Fast-Max Day Severe Congestion and Cough and Mucinex Nightshift Night Cold and Flu Maximum Strength",
"Mucinex Fast-Max Day Severe Congestion and Cough and Night Cold and Flu",
"Mucinex Fast-Max Day Severe Congestion and Cough and Night Cold and Flu",
"Mucinex Fast-Max Day Time Cold and Flu and Night Time Cold and Flu",
"Mucinex Fast-Max Day Time Cold and Flu and Night Time Cold and Flu",
"Mucinex Fast-Max Day Time Severe Cold and Mucinex Fast-Max Night Time Cold and Flu Maximum Strength",
"Mucinex Fast-Max Day Time Severe Cold and Mucinex Fast-Max Night Time Cold and Flu Maximum Strength",
"Mucinex Fast-Max Day Time Severe Cold and Mucinex Fast-Max Night Time Cold and Flu Maximum Strength",
"Mucinex Fast-Max Day Time Severe Cold and Mucinex Fast-Max Night Time Cold and Flu Maximum Strength",
"Mucinex Fast-Max Day Time Severe Cold and Mucinex Fast-Max Night Time Cold and Flu Maximum Strength",
"Mucinex Fast-Max Day Time Severe Cold and Mucinex Fast-Max Night Time Cold and Flu Maximum Strength",
"Mucinex Fast-Max Day Time Severe Cold and Mucinex Fast-Max Night Time Cold and Flu Maximum Strength",
"Mucinex Fast-Max Day Time Severe Cold and Mucinex Fast-Max Night Time Cold and Flu Maximum Strength",
"Mucinex Fast-Max Day Time Severe Congestion and Cough - Mucinex Fast-Max Night Time Cold and Flu Maximum Strength",
"Mucinex Fast-Max Day Time Severe Congestion and Cough - Mucinex Fast-Max Night Time Cold and Flu Maximum Strength",
"Mucinex Fast-Max Day Time Severe Congestion and Cough and Mucinex Fast-Max Night Time Cold and Flu Maximum Strength",
"Mucinex Fast-Max Day Time Severe Congestion and Cough and Mucinex Fast-Max Night Time Cold and Flu Maximum Strength",
"Mucinex Fast-Max Day Time Severe Congestion and Cough and Mucinex Fast-Max Night Time Cold and Flu Maximum Strength",
"Mucinex Fast-Max Day Time Severe Congestion and Cough and Mucinex Fast-Max Night Time Cold and Flu Maximum Strength",
"Mucinex Fast-Max Kickstart Severe Cold and Flu",
"Mucinex Fast-Max Night Time Cold and Flu",
"Mucinex Fast-Max Night Time Cold and Flu",
"Mucinex Fast-Max Night Time Cold and Flu",
"Mucinex Fast-Max Night Time Cold and Flu",
"Mucinex Fast-Max Night Time Cold and Flu Clear and Cool",
"Mucinex Fast-Max Severe Cold",
"Mucinex Fast-Max Severe Cold",
"Mucinex Fast-Max Severe Cold",
"Mucinex Fast-Max SEVERE COLD",
"Mucinex Fast-Max Severe Cold",
"Mucinex Fast-Max Severe Cold and Sinus",
"Mucinex Fast-Max Severe Congestion and Cold",
"Mucinex Fast-Max Severe Congestion and Cough",
"Mucinex Fast-Max Severe Congestion and Cough",
"Mucinex Fast-Max Severe Congestion and Cough",
"Mucinex Fast-Max Severe Congestion and Cough",
"Mucinex Fast-Max Severe Congestion and Cough",
"Mucinex Fast-Max Severe Congestion and Cough and Mucinex Nightshift Cold and Flu",
"Mucinex Fast-Max Severe Congestion and Cough Arctic Burst Maximum Strength",
"Mucinex Fast-Max Severe Congestion and Cough Clear and Cool",
"Mucinex Fast-Max Severe Congestion and Cough Clear and Cool and Maximum Strength Mucinex Nightshift Cold and Flu Clear and Cool",
"Mucinex Fast-Max Severe Congestion and Cough Clear and Cool and Maximum Strength Mucinex Nightshift Cold and Flu Clear and Cool",
"Mucinex Fast-Max Severe Congestion and Cough Clear and Cool and Mucinex Fast-Max Night Time Cold and Flu Clear and Cool",
"Mucinex Fast-Max Severe Congestion and Cough Clear and Cool and Mucinex Fast-Max Night Time Cold and Flu Clear and Cool",
"Mucinex Fast-Max Severe Congestion and Cough Liquid Pouches",
"Mucinex FreeFrom Cold and Flu Daytime",
"Mucinex FreeFrom Cold and Flu Daytime and Mucinex FreeFrom Cold and Flu Nighttime",
"Mucinex FreeFrom Cold and Flu Daytime and Mucinex FreeFrom Cold and Flu Nighttime",
"Mucinex FreeFrom Cold and Flu Nighttime",
"Mucinex FreeFrom Cold, Flu and Congestion",
"Mucinex FreeFrom Severe Congestion and Cough",
"Mucinex Junior Cold and Flu",
"Mucinex Multi-action Cold & Sinus Liquid",
"Mucinex Multi-action Congestion & Cold Caplets",
"Mucinex Multi-action Congestion, Cold & Cough",
"Mucinex Multi-action Congestion, Cold & Cough Solution",
"Mucinex Multi-action Congestion, Cold & Flu",
"Mucinex Multi-action Congestion, Stuffy Nose & Cough Liquid",
"Mucinex Night Time Severe Cold and Flu",
"Mucinex Nightshift Cold and Flu Clear and Cool",
"Mucinex Nightshift Severe Cold and Flu",
"Mucinex Nightshift Severe Cold and Flu Arctic Burst",
"Mucinex Nightshift Severe Cold and Flu Maximum Strength",
"Mucinex Nightshift Sinus",
"Mucinex Nightshift Sinus Clear and Cool",
"Mucinex Nightshift Sinus Maximum Strength",
"Mucinex Sinus - Max Day / Night",
"Mucinex Sinus - Max Day / Night",
"Mucinex Sinus-action Complete Congestion and Sinus Pain",
"Mucinex Sinus-action Pressure, Pain & Congestion",
"Mucinex Sinus-Max Day and Night Maximum Strength",
"Mucinex Sinus-Max Day and Night Maximum Strength",
"Mucinex Sinus-Max Day Night",
"Mucinex Sinus-Max Day Night",
"Mucinex Sinus-Max Day Night",
"Mucinex Sinus-Max Day Night",
"Mucinex Sinus-Max Day Night Maximum Strength",
"Mucinex Sinus-Max Day Night Maximum Strength",
"Mucinex Sinus-Max Day Pressure, Pain and Cough and Mucinex Nightshift Night Sinus Maximum Strength",
"Mucinex Sinus-Max Day Pressure, Pain and Cough and Mucinex Nightshift Night Sinus Maximum Strength",
"Mucinex Sinus-Max Day Time Severe Congestion Relief and Mucinex Sinus-Max Night Time Congestion and Cough Maximum Strength",
"Mucinex Sinus-Max Day Time Severe Congestion Relief and Mucinex Sinus-Max Night Time Congestion and Cough Maximum Strength",
"Mucinex Sinus-Max Night Time Congestion And Cough",
"Mucinex Sinus-Max Pressure and Pain",
"Mucinex Sinus-Max Pressure and Pain",
"Mucinex Sinus-Max Pressure and Pain",
"Mucinex Sinus-Max Pressure and Pain",
"Mucinex Sinus-Max Pressure, Pain and Cough",
"Mucinex Sinus-Max Pressure, Pain and Cough",
"Mucinex Sinus-Max Pressure, Pain and Cough and Mucinex Sinus-Max Severe Congestion Relief Clear and Cool",
"Mucinex Sinus-Max Pressure, Pain and Cough Maximum Strength",
"Mucinex Sinus-Max Severe Congestion and Pain",
"Mucinex Sinus-Max Severe Congestion and Pain Maximum Strength",
"Mucinex Sinus-Max Severe Congestion and Pain, Maximum Strength",
"Mucinex Sinus-Max Severe Congestion Relief",
"Mucinex Sinus-Max Severe Congestion Relief",
"Mucinex Sinus-Max Severe Congestion Relief",
"Mucinex Sinus-Max Severe Congestion Relief Clear and Cool",
"Mucinex Sinus-Max Severe Congestion Relief Maximum Strength",
"Mucinex-Sinus Max Severe Congestion and Pain Clear and Cool and Mucinex Nightshift Sinus Clear and Cool",
"Mucinex-Sinus Max Severe Congestion and Pain Clear and Cool and Mucinex Nightshift Sinus Clear and Cool",
"Mucus and Sinus PE",
"Mucus Congestion and Cough Relief Childrens",
"Mucus DM Fast Max Day Cold and Flu and Night Cold and Flu",
"Mucus DM Fast Max Day Cold and Flu and Night Cold and Flu",
"Mucus Fast Max Day Cold and Flu and Night Cold and Flu",
"Mucus Fast Max Day Cold and Flu and Night Cold and Flu",
"Mucus Multi Symptom Cold Relief Childrens",
"Mucus Relief",
"Mucus Relief All In One Cold and Flu",
"Mucus Relief All In One Daytime Nighttime Cold Flu Maximum Strength",
"Mucus Relief All In One Daytime Nighttime Cold Flu Maximum Strength",
"Mucus Relief All in One Maximum Strength",
"Mucus Relief All in One Maximum Strength",
"Mucus Relief All in One Maximum Strength",
"Mucus Relief Cold and Flu",
"Mucus Relief Cold and Flu",
"Mucus Relief Cold and Flu All In One",
"Mucus Relief Cold and Flu All in One",
"Mucus Relief Cold and Flu all in one",
"Mucus Relief Cold and Flu All in One",
"Mucus Relief Cold and Flu All in One",
"Mucus Relief Cold and Flu All in One",
"Mucus Relief Cold and Flu Daytime Nighttime",
"Mucus Relief Cold and Flu Daytime Nighttime",
"Mucus Relief cold and flu Daytime/Nighttime",
"Mucus Relief cold and flu Daytime/Nighttime",
"Mucus Relief Cold and Sinus",
"Mucus Relief Cold and Sinus",
"Mucus Relief cold and sinus",
"Mucus Relief Cold and Sinus",
"Mucus Relief Cold and SInus Max Maximum Strength",
"Mucus Relief Cold and Sinus Maximum Strength",
"Mucus Relief Cold and Sinus Maximum Strength",
"Mucus Relief Cold and Sinus Maximum Strength",
"Mucus Relief Cold and Sinus Maximum Strength",
"Mucus Relief Cold and Sinus Maximum Strength",
"Mucus Relief Cold and Sinus Maximum Strength",
"Mucus Relief Cold and Sinus Maximum Strength",
"Mucus Relief Cold and Sinus Maximum Strength",
"Mucus Relief Cold and Sinus Maximum Strength",
"Mucus Relief Cold Flu and Sore Throat",
"Mucus Relief cold flu and sore throat",
"Mucus Relief Cold Flu and Sore Throat",
"Mucus Relief Cold Flu and Sore Throat",
"Mucus Relief Cold Flu and Sore Throat",
"Mucus Relief Cold Flu and Sore Throat",
"Mucus Relief Cold Flu and Sore Throat",
"Mucus Relief Cold Flu and Sore Throat",
"Mucus Relief Cold Flu and Sore Throat",
"Mucus Relief Cold Flu and Sore Throat",
"Mucus Relief Cold Flu and Sore Throat",
"Mucus Relief Cold Flu and Sore Throat",
"Mucus Relief Cold Flu and Sore Throat Max Maximum Strength",
"Mucus Relief Cold Flu and Sore Throat Maximum Strength",
"Mucus Relief Cold Flu and Sore Throat Maximum Strength",
"Mucus Relief Cold Flu and Sore Throat Maximum Strength",
"Mucus Relief Cold Flu and Sore Throat Maximum Strength",
"Mucus Relief Cold Flu and Sore Throat Maximum Strength",
"Mucus Relief Cold Flu and Sore Throat Maximum Strength",
"Mucus Relief Cold Flu and Sore Throat Maximum Strength",
"Mucus Relief Cold Flu and Sore Throat Maximum Strength",
"Mucus Relief Cold Flu and Sore Throat Maximum Strength",
"Mucus Relief Cold Flu and Sore Throat Maximum Strength",
"Mucus Relief Cold Flu and Sore Throat Maximum Strength",
"Mucus Relief Cold Flu and Sore Throat Maximum Strength",
"Mucus Relief Cold Flu Sore Throat",
"Mucus Relief Cold Flu Sore Throat Maximum Strength",
"Mucus Relief Cold Flu Sore Throat Maximum Strength",
"Mucus Relief Cold Flu Sore Throat Maximum Strength",
"Mucus Relief Cold Flu Sore Throat Maximum Strength",
"Mucus Relief Cold Flu Sore Throat Maximum Strength",
"Mucus Relief Cold Flu Sore Throat Maximum Strength",
"Mucus Relief Cold Flu Sore Throat Maximum Strength",
"Mucus Relief Cold, Flu and Sore Throat",
"Mucus Relief Cold, Flu and Sore Throat",
"Mucus Relief Cold, Flu and Sore Throat",
"Mucus Relief Cold, Flu and Sore Throat",
"Mucus Relief Cold, Flu and Sore Throat",
"Mucus Relief Cold, Flu and Sore Throat",
"Mucus Relief Cold, Flu and Sore Throat",
"Mucus Relief Cold, Flu and Sore Throat",
"Mucus Relief Cold, Flu and Sore Throat Maximum Strength",
"Mucus Relief Cold, Flu and Sore Throat Maximum Strength",
"Mucus Relief Cold, Flu and Sore Throat Maximum Strength",
"Mucus Relief Cold, Flu and Sore Throat Maximum Strength",
"Mucus Relief Cold, Flu and Sore Throat Maximum Strength",
"Mucus Relief Cold, Flu, and Sore Throat Maximum Strength",
"Mucus Relief Cold, Flu, Sore Throat Maximum Strength",
"Mucus Relief Cold, Flu, Sore Throat Maximum Strength",
"Mucus Relief Complete",
"Mucus Relief Congestion and Cough Maximum Strength",
"Mucus Relief Congestion and Cough Maximum Strength",
"Mucus Relief Congestion and Headache Maximum Strength",
"Mucus Relief Congestion and Headache Maximum Strength",
"Mucus Relief Congestion Cough Maximum Strength Severe Congestion and Cough",
"Mucus Relief Cough Cold Sore Throat",
"Mucus Relief D Immediate Release",
"Mucus Relief D Immediate Release",
"Mucus Relief Day Time and Night Time",
"Mucus Relief Day Time and Night Time",
"Mucus Relief Daytime Severe Cold Nighttime Cold and Flu Maximum Strength",
"Mucus Relief Daytime Severe Cold Nighttime Cold and Flu Maximum Strength",
"Mucus Relief Daytime Severe Cold Nighttime Cold and Flu Maximum Strength",
"Mucus Relief Daytime Severe Cold Nighttime Cold and Flu Maximum Strength",
"Mucus Relief Daytime/Nighttime",
"Mucus Relief Daytime/Nighttime",
"Mucus Relief Daytime/Nighttime/Maximum Strength",
"Mucus Relief Daytime/Nighttime/Maximum Strength",
"Mucus Relief DM MAX Maximum Strength",
"Mucus Relief Maximum Strength",
"Mucus Relief Maximum Strength",
"Mucus Relief Maximum Strength",
"Mucus Relief Maximum Strength",
"Mucus Relief MAXIMUM STRENGTH",
"Mucus Relief Maximum Strength",
"Mucus Relief Maximum Strength Multi Symptom Relief",
"Mucus Relief Maximum Strength Severe Congestion and Cough",
"Mucus Relief Maximum StrengthCold Flu and Sore Throat",
"Mucus Relief Maximum StrengthCold Flu and Sore Throat",
"Mucus Relief Maximum StrengthCold Flu and Sore Throat",
"Mucus Relief Nighttime Cold Flu Maximum StrengthCold Flu and Sore Throat",
"Mucus Relief Nighttime Congestion Cough Maximum Strength",
"Mucus Relief PE",
"Mucus Relief PE",
"Mucus Relief PE",
"Mucus Relief PE Sinus Congestion",
"Mucus Relief Plus",
"Mucus Relief Plus",
"Mucus Relief Severe Cold",
"Mucus Relief Severe Cold",
"Mucus Relief Severe Cold",
"Mucus Relief Severe Cold",
"Mucus Relief Severe Cold",
"Mucus Relief Severe Cold Daytime Cold and Flu Nighttime",
"Mucus Relief Severe Cold Daytime Cold and Flu Nighttime",
"Mucus Relief Severe Cold Daytime Maximum Strength",
"Mucus Relief Severe Cold Daytime Maximum Strength",
"Mucus Relief Severe Congestion and Cold",
"Mucus Relief Severe Congestion and Cold",
"Mucus Relief Severe Congestion and Cold",
"Mucus Relief Severe Congestion and Cold Max Maximum Strength",
"Mucus Relief Severe Congestion and Cough",
"Mucus Relief Severe Congestion and Cough",
"Mucus Relief Severe Congestion and Cough Maximum Strength",
"Mucus Relief Severe Congestion and Cough Maximum Strength",
"Mucus Relief Severe Congestion and Cough Maximum Strength",
"Mucus Relief Severe Congestion and Cough Maximum Strength",
"Mucus Relief Severe Congestion and Cough Maximum Strength",
"Mucus Relief Severe Congestion and Cough Maximum Strength",
"Mucus Relief Severe Congestion and Cough Maximum Strength",
"Mucus Relief Severe Congestion and Cough Maximum Strength",
"Mucus Relief Severe Congestion and Cough Maximum Strength",
"Mucus Relief Severe Congestion and Cough Maximum Strength",
"Mucus Relief Severe Congestion and Cough Maximum Strength",
"Mucus Relief Severe Congestion and Cough Maximum Strength",
"Mucus Relief Severe Congestion and Cough Maximum Strength",
"Mucus Relief Severe Congestion and Cough Maximum Strength",
"Mucus Relief Severe Congestion and Cough Maximum Strength",
"Mucus Relief Severe Congestion and Cough Maximum Strength",
"Mucus Relief Severe Congestion and Cough Maximum Strength",
"Mucus Relief Severe Congestion and Cough Maximum Strength",
"Mucus Relief Severe Congestion and Cough Maximum Strength",
"Mucus Relief Severe Congestion and Cough Maximum Strength",
"Mucus Relief Severe Congestion and Cough Multi Symptom Relief",
"Mucus Relief Severe Congestion and Sinus",
"Mucus Relief Severe Congestion Cough Maximum Strength",
"Mucus Relief Severe Congestion Cough Night Time Cold and Flu Maximum Strength",
"Mucus Relief Severe Congestion Cough Night Time Cold and Flu Maximum Strength",
"Mucus Relief Severe Cough and Congestion",
"Mucus Relief Severe Sinus Congestion",
"Mucus Relief Severe Sinus Congestion Maximum Strength",
"Mucus Relief Sinus",
"Mucus Relief Sinus",
"Mucus Relief Sinus",
"Mucus Relief Sinus Congestion Daytime Nighttime Maximum Strength",
"Mucus Relief Sinus Congestion Daytime Nighttime Maximum Strength",
"Mucus Relief Sinus Day and Night",
"Mucus Relief Sinus Day and Night",
"Mucus Relief Sinus Pressure and Pain",
"Mucus Relief Sinus Pressure and Pain",
"Mucus Relief Sinus Pressure Pain and Cough",
"Mucus Relief Sinus Pressure Pain and Cough",
"Mucus Relief Sinus Pressure Pain and Cough",
"Mucus Relief Sinus Pressure Pain and Cough",
"Mucus Relief Sinus Pressure Pain and Cough",
"Mucus Relief Sinus Pressure, Pain and Cough",
"Mucus Relief Sinus Severe Congestion and Pain",
"Mucus Relief Sinus Severe Congestion and Pain",
"Mucus Relief Sinus Severe Congestion and Pain",
"Mucus Relief Sinus Severe Congestion and Pain",
"Mucus Relief Sinus Severe Congestion Relief",
"Mucus Relief Sinus Severe Congestion Relief",
"Mucus Relief Sinus Severe Congestion Relief",
"Mucus Relief Sinus Severe Congestion Relief",
"Mucus Relief Sinus Severe Congestion Relief",
"Mucus Relief, Cold, Flu and Sore Throat Maximum Strength, Multi-Symptom",
"Mucus Sinus Relief Day and Night",
"Mucus Sinus Relief Day and Night",
"Multi Symptom Cold",
"Multi Symptom Cold",
"Multi Symptom Cold",
"Multi Symptom Cold",
"Multi Symptom Cold Allergy Tabs",
"Multi Symptom Cold and Multi Symptom Nighttime Cold Childrens",
"Multi Symptom Cold and Multi Symptom Nighttime Cold Childrens",
"Multi Symptom Cold and Multi Symptom Nighttime Cold Childrens",
"Multi Symptom Cold and Multi Symptom Nighttime Cold Childrens",
"Multi Symptom Cold CF",
"Multi Symptom Cold CF",
"Multi Symptom Cold CF",
"Multi Symptom Cold CF Adult",
"Multi Symptom Cold Childrens",
"Multi Symptom Cold Childrens Plus",
"Multi Symptom Cold Double Max Power",
"Multi Symptom Cold Plus Childrens",
"Multi Symptom Cold Plus Childrens Pain Relief",
"Multi Symptom Cold Relief CF Non Drowsy",
"Multi Symptom Cold Relief Childrens",
"Multi Symptom Daytime",
"Multi Symptom Fever and Cold Childrens",
"Multi Symptom NightTime Cold",
"Multi Symptom Severe Cold",
"Multi Symptom Severe Cold",
"Multi Symptom Severe Cold",
"Multi Symptom Severe Cold and Nighttime Severe Cold and Cough",
"Multi Symptom Severe Cold and Nighttime Severe Cold and Cough",
"Multi Symptom Severe Cold and Nighttime Severe Cold and Cough",
"Multi Symptom Severe Cold and Nighttime Severe Cold and Cough",
"Multi Symptom Severe Cold and Nighttime Severe Cold and Cough",
"Multi Symptom Severe Cold and Nighttime Severe Cold and Cough",
"Multi Symptom Severe Cold PE",
"Multi Symptom Sinus Relief Pain and Congestion Daytime Nighttime",
"Multi Symptom Sinus Relief Pain and Congestion Daytime Nighttime",
"Multi Symptom Wal Flu Severe Cold",
"Multi Sympton Cold Day Night",
"Multi Sympton Cold Day Night",
"Multi Sympton Cold Day Night",
"Multi Sympton Cold Day Night",
"Multi- Symptom Relief DayTime",
"Multi-Symptom Allergy",
"Multi-Symptom Cold",
"Multi-Symptom Cold",
"Multi-Symptom Cold and Cough Daytime Nighttime",
"Multi-Symptom Cold and Cough Daytime Nighttime",
"Multi-Symptom Cold and Fever Childrens",
"Multi-Symptom Cold and Flu DayTime",
"Multi-Symptom Cold and Flu DayTime",
"Multi-symptom Cold and Flu Relief Daytime",
"Multi-symptom Cold and Flu Relief Daytime Nighttime",
"Multi-Symptom Cold and Sinus Maximum Strength",
"Multi-Symptom Cold childrens",
"Multi-Symptom Cold Daytime",
"Multi-Symptom Cold Daytime",
"Multi-Symptom Cold Flu and Sore Throat Maximum Strength",
"Multi-Symptom Cold Flu and Sore Throat Maximum Strength",
"Multi-Symptom Cold Relief",
"Multi-Symptom Cold Relief",
"Multi-Symptom Cold Relief",
"Multi-Symptom Cold Relief",
"Multi-Symptom Cold Relief",
"Multi-Symptom Cold Relief",
"Multi-Symptom Cold Relief",
"Multi-Symptom Cold Relief",
"Multi-Symptom Cold Relief",
"Multi-Symptom Cold Relief",
"Multi-Symptom Cold Relief",
"Multi-Symptom Cold Relief",
"Multi-Symptom Cold Relief Daytime",
"Multi-Symptom Cold Relief Daytime, Nighttime",
"Multi-Symptom Cold Relief Daytime, Nighttime",
"multi-symptom cold relief Daytime, Nighttime",
"multi-symptom cold relief Daytime, Nighttime",
"Multi-Symptom Cold Severe, Non-Drowsy, Daytime",
"Multi-Symptom Cold Warming Effect Daytime",
"Multi-symptom Daytime",
"Multi-symptom Daytime",
"Multi-symptom Daytime",
"Multi-symptom Daytime",
"Multi-symptom Daytime",
"Multi-symptom Daytime",
"Multi-symptom Daytime",
"Multi-symptom Daytime",
"Multi-symptom Daytime",
"Multi-symptom Daytime",
"Multi-symptom Daytime",
"Multi-symptom Daytime",
"Multi-symptom Daytime",
"Multi-symptom Daytime",
"Multi-Symptom Daytime and Nighttime Cold and Flu Relief Plus",
"Multi-Symptom Daytime and Nighttime Cold and Flu Relief Plus",
"Multi-Symptom Daytime Cold",
"Multi-Symptom Daytime Cold",
"Multi-Symptom Daytime Cold",
"Multi-Symptom Daytime Cold Rapid Release",
"Multi-Symptom Mapap Cold Formula",
"Multi-Symptom Mapap Cold Formula",
"Multi-Symptom Nighttime Cold",
"Multi-Symptom Nighttime Sinus Relief",
"Multi-Symptom Relief Cold and Flu Multi-Symptom Relief",
"Multi-Symptom Severe Cold",
"Multi-Symptom Sinus Severe Congestion",
"Mydcombi",
"Mydfrin",
"Mydfrin",
"Mydfrin",
"Mydriatic-3",
"Mydriatic-4",
"MyHist DM",
"N - Time Sinus",
"Nasal",
"Nasal",
"Nasal",
"Nasal + Sinus Cold Formula",
"Nasal and Sinus Decongestant",
"NASAL and SINUS DECONGESTANT",
"NASAL and SINUS DECONGESTANT",
"Nasal Decongestant",
"Nasal Decongestant",
"Nasal Decongestant",
"Nasal Decongestant",
"Nasal Decongestant",
"Nasal Decongestant",
"Nasal Decongestant",
"Nasal Decongestant",
"Nasal Decongestant",
"Nasal Decongestant",
"Nasal Decongestant",
"Nasal Decongestant",
"Nasal Decongestant",
"Nasal Decongestant",
"Nasal Decongestant Maximum Strength",
"Nasal Decongestant Maximum Strength",
"Nasal Decongestant Maximum Strength",
"Nasal Decongestant Non-Drowsy",
"Nasal Decongestant PE",
"Nasal Decongestant PE",
"Nasal Decongestant PE",
"Nasal Decongestant PE",
"Nasal Decongestant PE",
"Nasal Decongestant PE",
"Nasal Decongestant PE",
"Nasal Decongestant PE",
"Nasal Decongestant PE",
"nasal decongestant PE",
"Nasal Decongestant PE",
"Nasal Decongestant PE",
"Nasal Decongestant PE",
"Nasal Decongestant PE",
"Nasal Decongestant PE",
"Nasal Decongestant PE",
"Nasal Decongestant PE",
"Nasal Decongestant PE",
"NASAL DECONGESTANT PE 10mg",
"Nasal Decongestant PE and Pain Relief Maximum Strength",
"Nasal Decongestant PE and Pain Relief Plus Mucus Relief",
"Nasal Decongestant PE Maximum Strength",
"Nasal Decongestant PE Maximum Strength",
"Nasal Decongestant PE Maximum Strength",
"Nasal Decongestant PE Maximum Strength",
"Nasal Decongestant PE Maximum Strength",
"Nasal Decongestant PE Maximum Strength",
"Nasal Decongestant PE Maximum Strength",
"Nasal Decongestant PE Maximum Strength Non Drowsy",
"Nasal Decongestant PE Maximum Strength Non Drowsy",
"Nasal Decongestant PE Maximum Strength Non-Drowsy",
"Nasal Decongestant PE Non Drowsy",
"Nasal Decongestant PE Non Drowsy",
"Nasal Decongestant PE Non Drowsy",
"Nasal Decongestant PE Non Drowsy Maximum Strength",
"Nasal Decongestant PE Non Drowsy Maximum Strength",
"Nasal Decongestant PE Non-Drowsy Maximum Strength",
"Nasal Decongestant PE Sinus Congestion Relief Non-Drowsy / Maximum Strength",
"Nasal Decongestant PE, Non-Drowsy",
"Nasal Decongestant Rhinall",
"Nasal Decongestant Rhinall",
"Nasal Four",
"Nasal Four",
"Nasal Four",
"Nasal Four",
"Nasohist DM Pediatric",
"Nasohist DM Pediatric",
"Nasohist Pediatric",
"Nasohist Pediatric",
"Nasopen PE",
"Nasotuss",
"Natureplex Hemorrhoidal",
"Natureplex Hemorrhoidal",
"Neo Citran A Powder",
"Neo Citran Extra Strength",
"Neo Citran Nutrasweet",
"Neo Citran Powder",
"Neo DM DROPS DM",
"Neo Synephrine Nasal Drop 1%",
"Neo Synephrine Nasal Spray",
"Neo Tuss Syr",
"Neo-Synephrine",
"Neo-Synephrine",
"Neo-Synephrine Cold and Sinus Extra Strength",
"Neo-Synephrine Cold and Sinus Extra Strength",
"Neo-Synephrine Cold and Sinus Mild Strength",
"Neo-Synephrine Cold and Sinus Mild Strength",
"Neo-Synephrine Cold and Sinus Regular Strength",
"Neo-Synephrine Cold and Sinus Regular Strength",
"Neo-Synephrine Extra Strength",
"Neo-Synephrine Extra Strength",
"Neo-Synephrine Hydrochloride",
"Neo-synephrine Inj Liq 10mg/ml",
"Neo-synephrine Liq 1%",
"Neo-Synephrine Maximum",
"Neo-Synephrine Mild",
"Neo-Synephrine Mild Strength",
"Neo-Synephrine Mild Strength",
"Neo-synephrine Nasal Drop 1%",
"Neo-synephrine Nasal Spray",
"Neo-Synephrine Regular",
"Neo-Synephrine Regular Strength",
"Neo-Synephrine Regular Strength",
"Neocitran Cold & Cough Night",
"Neocitran Cold & Sore Throat Night",
"Neocitran Extra Strength Cold & Congestion",
"Neocitran Extra Strength Cold & Sinus Night",
"Neocitran Extra Strength Cold & Sinus Night - Apple Cinnamon",
"Neocitran Extra Strength Total Cold",
"Neocitran Extra Strength Total Cold Night",
"Neocitran Thin Strips Daytime Cough and Cold",
"Neocitran Thin Strips Nighttime Cough and Cold",
"Neocitran Total Cold",
"Neocitran Total Cold Night",
"Neogen-D",
"NEXT COLD and FLU DAYTIME",
"Next Day Time Non drowsy Cold and Flue",
"Next Day Time Non drowsy Cold and Flue",
"Next Night Severe Cold, Flu and Sore Throat",
"NEXT Severe Cold, Flu and Sore Throate Night Max Strength",
"Nezger Tab",
"Night Cold and Flu Relief",
"Night Cold Flu Cough and Allergy",
"Night Relief sinus",
"Night Time Cold & Flu Liquid",
"Night Time Cold and Cough Childrens",
"Night Time Cold and Flu",
"Night Time Cold and Flu",
"Night Time Cold and Flu",
"NIGHT TIME COLD and FLU FORMULA",
"Night Time Cold and Flu Severe",
"Night Time Cold Max",
"Night Time Cold Multi-Symptom",
"Night Time Cough and Cold Relief",
"Night Time Day Time",
"Night time Multi Sympton Cold Max",
"Night Time Severe Cold and Cough",
"Night Time Severe Cold and Cough",
"Night Time Severe Cold and Cough Relief",
"Night Time Severe Cold and Cough Relief",
"Night Time Severe Cold and Flu",
"Night Time Severe Cold and Flu Relief",
"Night Time Sinus",
"Night time sinus",
"Night Time Sinus and Congestion",
"Night Time Sinus Congestion and Pain",
"Night Time Sinus Relief",
"NightRelief DayRelief",
"Nighttime",
"Nighttime Cold",
"NightTime Cold",
"NightTime Cold",
"Nighttime Cold & Flu Relief Liquid Gels",
"NightTime Cold and Cough Children",
"Nighttime Cold and Cough childrens",
"Nighttime Cold and Cough Childrens",
"Nighttime Cold and Cough childrens",
"Nighttime Cold and Cough Sugar-Free",
"Nighttime Cold and Flu",
"Nighttime Cold and Flu",
"Nighttime Cold and Flu",
"Nighttime Cold and Flu",
"NightTime Cold and Flu",
"NIGHTTIME Cold and Flu Max Softgels MAXIMUM STRENGTH",
"Nighttime Cold and Flu Maximum Strength",
"Nighttime Cold and Flu Maximum Strength",
"Nighttime Cold and Flu Maximum Strength",
"Nighttime Cold and Flu Maximum Strength",
"NIGHTTIME COLD AND FLU Maximum Strength",
"Nighttime Cold and Flu Relief Plus",
"Nighttime Cold and Flu Relief Therapy",
"Nighttime Cold Head Congestion",
"Nighttime Cold Max",
"Nighttime Cold Medicine",
"Nighttime Cold Multi-Symptom Cool Blast",
"Nighttime Cold Relief Extra Strength Tablets PE",
"Nighttime Complete",
"NightTime DayTime Severe Cold and Flu",
"NightTime DayTime Severe Cold and Flu",
"Nighttime Extra Strength Contac Cold & Sore Throat",
"Nighttime Extra Strength Contac Complete Cough, Cold & Flu",
"Nighttime Extra Strength Contac Complete Cough, Cold & Flu Plus Vitamin C",
"Nighttime Flu and Severe",
"Nighttime Flu Relief Therapy Severe Cold",
"Nighttime Flu Relief Therapy Severe Cold",
"NightTime Maximum Strength Cold and Flu",
"Nighttime Multi-Symptom Cold",
"Nighttime Regular Strength Contac Cold Nasal Congestion",
"NightTime Relief Severe Cold and Flu",
"Nighttime severe",
"Nighttime Severe",
"Nighttime Severe",
"Nighttime Severe Cold and Cough",
"Nighttime Severe Cold and Cough",
"Nighttime Severe Cold and Cough",
"Nighttime Severe Cold and Flu",
"NightTime Severe Cold and Flu",
"Nighttime Severe Cold and Flu",
"Nighttime SEVERE COLD and FLU",
"Nighttime Severe Cold and Flu",
"Nighttime Severe Cold and Flu",
"Nighttime Severe Cold and Flu",
"Nighttime Severe Cold and Flu",
"Nighttime Severe Cold and Flu",
"Nighttime Severe Cold and Flu Relief",
"Nighttime Severe Cold and Flu Relief",
"Nighttime Severe cold cough and flu relief",
"Nighttime Severe Cough and Cold",
"NightTime Sinus",
"Nighttime sinus",
"Nighttime Sinus and Congestion Relief",
"Nighttime Sinus Multi symptom",
"NightTime Sinus Relief",
"Nighttime Sinus Relief",
"NightTime Sinus Relief",
"Nighttime Sinus Relief",
"Nighttime Symptom Relief Extra Strength for Symptoms Of Cold and Cough",
"Nighttime Wal Flu Severe Cold and Cough",
"Nikzon Hemorrhoidal",
"Nikzon Hemorrhoidal",
"Nite Time Cold and Cough",
"Nite Time Cold and Cough",
"Nite Time Cold and Cough",
"Nite Time Cold and Flu",
"Nite Time Cold and Flu",
"Nite Time Day Time",
"Nite time Severe Cold and Flu Maximum Strength",
"Nitecap Sinus Liquid Gels",
"Nitecap Sinus Liquid Gels",
"Niteclear Cold and Flu Relief",
"Nitetime Cold and Flu",
"Nitetime Cold and Flu",
"Nitetime Cold Relief Extra Strength",
"NiteTime DayTime Cold and Flu",
"NiteTime DayTime Cold and Flu",
"Nitetime Severe Cold and Flu Relief",
"NiteTime Sinus",
"NiteTime Sinus",
"Nitetime Sinus Relief",
"NiteTime Sinus Relief",
"Niva-Hist DM",
"Nivanex DMX",
"NoHist",
"NoHist DM",
"NoHist LQ",
"Non Drowsy Cold and Cough PE",
"Non Drowsy Cold and Cough PE",
"Non Drowsy DAY and NIGHT Multi-Symptom Cold and Flu Formula",
"Non Drowsy DAY and NIGHT Multi-Symptom Cold and Flu Formula",
"Non Drowsy DAY Cold and Flu Plus and NIGHTTIME Cold and Flu Plus",
"Non Drowsy DAY Cold and Flu Plus and NIGHTTIME Cold and Flu Plus",
"Non Drowsy Day Time cold and Flu Relief",
"Non Drowsy Daytime and Nighttime Cold and Flu",
"Non Drowsy DAYTIME and NIGHTTIME Sinus Congestion and Cough Relief",
"Non Drowsy DAYTIME and NIGHTTIME Sinus Congestion and Cough Relief",
"Non Drowsy DAYTIME and NIGHTTIME Sinus Congestion and Cough Relief",
"Non Drowsy DAYTIME and NIGHTTIME Sinus Congestion and Cough Relief",
"Non Drowsy Daytime Cold and Flu Softgel",
"Non Drowsy Severe Daytime and Nighttime Cold and Flu Relief",
"Non Drowsy Severe Daytime and Nighttime Cold and Flu Relief",
"Non-drowsy Day Time",
"NON-DROWSY DAYTIME Cold and Flu Max Softgels MAXIMUM STRENGTH",
"Non-Drowsy DayTime Cold and Flu Multi-Symptom Relief",
"Non-Drowsy Daytime Multi Symptom Cold and Flu Relief",
"Non-Drowsy Daytime Multi-Symptom Cold and Flu",
"Non-Drowsy Daytime Severe Cold Multi-Symptom",
"Non-Drowsy Daytime Severe Sinus Congestion and Pain",
"Non-drowsy Daytime Sinus Relief",
"Non-Drowsy Max Cold",
"Non-Drowsy Nasal Decongestant PE",
"Non-Drowsy Sinus Daytime",
"Non-Drowsy Sinus Severe, Circle K",
"Non-Drowsy Sinus Severe, Circle K",
"Non-Drowsy Suphedrine PE Congestion",
"Non-Drowsy Wal-Phed PE Triple Relief",
"Non-Drying Sinus PE",
"Norel AD",
"Norel SR",
"NorelCS CS",
"North Sinus Decongestant",
"Nose",
"Nose",
"Notuss PE",
"Novahistex C",
"Novahistex Dh",
"Novahistex Dh Expectorant",
"Novahistine Decon Liq 5mg/5ml",
"Novahistine Decongestant - Liq 5mg/5ml",
"Novahistine Dh",
"Novalgina Children Cough and Cold",
"Novalgina Children Cough and Cold",
"Novalgina Pediatrico Cough and Cold Pediatrico",
"NovexCold",
"Novexcold Extra Strength",
"Nu-copd",
"Numb Squeeze",
"Numb520",
"Nyquil Complete",
"Nyquil Complete + Vicks Vapocool",
"Nyquil Complete + Vicks Vapocool Cold & Flu Liquid",
"Nyquil Cough DM + Congestion",
"Nyquil Kids",
"NyQuil Severe",
"NyQuil Severe Cold and Flu",
"NyQuil Severe Cold and Flu",
"Nyquil Severe Cold Flu",
"Nyquil Severe Cold Flu",
"Nyquil Severe Cold Flu",
"NyQuil Severe Plus VapoCOOL Cold and Flu",
"NyQuil Severe plus Vicks VapoCool",
"NyQuil Severe plus Vicks VapoCool Cold and Flu",
"NyQuil Severe Plus Vicks Vapocool Cold and Flu",
"NyQuil Severe VapoCool",
"Nyquil Sinus Liquicaps",
"NyQuil VapoCOOL SEVERE COLD and FLU plus CONGESTION",
"Occu-cal Drops",
"Occu-cal Lotion",
"Odan-phenylephrine",
"Odan-vernacon",
"Olp Hemorrhoidal Cooling",
"Omidria",
"Omidria",
"Omidria Intraocular Irrigation",
"Only For COLD AND FLU COUGH SUPPRESSANT",
"Oral Infant Cold Drops",
"Ortizol Otic Solution",
"Otis Clapp Emagrin Forte",
"Otis Clapp Emagrin Forte",
"Otis Clapp Emagrin Forte",
"Otis Clapp Mygrex",
"Otis Clapp Mygrex",
"Otis Clapp Valihist",
"Otis Clapp Valihist",
"Our Family day time severe cold and Cough berry infused with menthol and green tea flavors",
"Our Family night time severe cold and cough honey lemon infused with chamomile and white tea flavors",
"Pain and Sinus Reliever",
"Pain and Sinus Reliever",
"Pain Relief",
"Pain Relief",
"Pain Relief Cold",
"Pain Relief Cold Multi Symptom",
"Pain Relief Non Drowsy Daytime",
"Pain Relief Non-Drowsy, Daytime",
"Pain Relief Plus",
"Pain Relief Plus Multi Symptom Cold Childrens",
"Pain Reliever Fever Reducer",
"Palagrip",
"Panadol",
"Panadol Cold and Flu NonDrowsy",
"Panadol Cold and Flu NonDrowsy",
"Panadol Cold and Flu NonDrowsy",
"Panatuss DXP",
"Panatuss Pediatric Drops DXP",
"Pancold A",
"PE Hist DM",
"PE multi-stymptom cold and cough relief",
"PE Sinus Congestion",
"PediaCare Childrens Allergy and Cold",
"Pediacare Childrens Cough and Cold Grape",
"PediaCare Childrens MultiSymptom Cold",
"PediaCare Childrens Nighttime Multi Symptom Cold",
"PediaCare Childrens Plus Flu",
"PediaCare Childrens Plus Multisymptom Cold",
"PediaCare Multi Symptom Cold",
"PediaCare Plus Multisymptom Cold",
"Pentrexcilina",
"Pentrexcilina",
"Pentrexcilina Daytime",
"Pharbinex-PE",
"Pharbinex-PE",
"Pharmacitron",
"Pharmetapp Elixir",
"Phenagil",
"Phenagil",
"Phenagil",
"Phenagil",
"Phenagil CH",
"Phenergan Vc Expectorant Syr",
"Phenergan Vc Expectorant W Codeine Liq",
"Phenyl-Lido",
"Phenylephrine",
"Phenylephrine",
"Phenylephrine Carbetapentane Potassium Guaiacolsulfonate",
"Phenylephrine Complex",
"Phenylephrine Guaifenesin",
"Phenylephrine Hci",
"Phenylephrine HCl",
"Phenylephrine HCl",
"Phenylephrine HCl",
"Phenylephrine HCl",
"Phenylephrine HCl",
"Phenylephrine HCl",
"Phenylephrine HCl",
"Phenylephrine HCl",
"Phenylephrine HCl Maximum Strength",
"Phenylephrine HCl Maximum Strength",
"Phenylephrine hydrochloride",
"Phenylephrine hydrochloride",
"Phenylephrine hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine hydrochloride",
"Phenylephrine hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine hydrochloride",
"Phenylephrine hydrochloride",
"Phenylephrine hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine hydrochloride",
"Phenylephrine hydrochloride",
"Phenylephrine hydrochloride",
"Phenylephrine hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine hydrochloride",
"Phenylephrine hydrochloride",
"Phenylephrine hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine hydrochloride",
"Phenylephrine hydrochloride",
"Phenylephrine hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine hydrochloride",
"Phenylephrine hydrochloride",
"Phenylephrine hydrochloride",
"Phenylephrine hydrochloride",
"Phenylephrine hydrochloride",
"Phenylephrine hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride Injection",
"Phenylephrine Hydrochloride Injection",
"Phenylephrine Hydrochloride Injection",
"Phenylephrine Hydrochloride Injection USP",
"Phenylephrine Hydrochloride Injection USP",
"Phenylephrine Hydrochloride Injection USP",
"Phenylephrine Hydrochloride Injection USP",
"Phenylephrine Hydrochloride Injection USP 1%",
"Phenylephrine Hydrochloride Injection USP 1%",
"Phenylephrine Hydrochloride Injection USP, 1%",
"Phenylephrine Hydrochloride Injection, USP",
"Phenylephrine Hydrochloride Injection, USP",
"Phenylephrine Hydrochloride Ophthalmic",
"Phenylephrine Hydrochloride Ophthalmic",
"Phenylephrine Hydrochloride Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride, Chlorpheniramine Maleate",
"Phenylephrine/hydroxyethylcellulose",
"Phenyltrope Oph Soln",
"Physicians Care Allergy",
"Physicians Care Allergy Plus",
"Physicians Care Cold and Cough",
"Physicians Care Cold and Cough",
"Physicians Care Cold Cough",
"Physicians Care Non-Drowsy Sinus",
"Physicians Care Non-Drowsy Sinus",
"Physicians Care Sinus",
"PhysiciansCare Allergy Multi-Symptom Relief",
"PhysiciansCare Cold and Cough Non-Drowsy",
"PhysiciansCare Cold and Cough Non-Drowsy",
"PhysiciansCare Sinus Non-Drowsy",
"Pluratuss",
"Plus Multi Symptom Cold Childrens Pain Relief",
"Poly Hist Dhc",
"Poly Hist Forte",
"Poly Hist Forte",
"Poly Hist Forte",
"Poly Hist Pd",
"Poly-Hist DM",
"Poly-Tussin AC",
"Poly-Tussin AC",
"Poly-tussin DM",
"Poly-tussin EX",
"Polytussin DM",
"Polytussin DM",
"Polytussin DM",
"Preferred Plus Chest Congestion Relief PE",
"Preferred Plus Childrens Mucus Relief Multi Symptom Cold",
"Preferred Plus Cold and Flu Night Time",
"Preferred Plus Congestion Relief",
"Preferred Plus Day Time Cold and Flu",
"Preferred Plus Hemorrhoid",
"Preferred Plus Hemorrhoidal",
"Preferred Plus Mucus Relief",
"Preferred Plus Mucus Relief Cold and Sinus",
"Preferred Plus Severe Cold",
"Preferred Plus Severe Cold Cough and Flu",
"Preferred Plus Severe Cold Cough and Flu",
"Preferred Plus Severe Cold Day Time Cold and Flu Night Time",
"Preferred Plus Severe Cold Day Time Cold and Flu Night Time",
"Preferred Plus Severe Day Time",
"Preferred Plus Severe Nite Time",
"Preferred Plus Severe Sinus Congestion",
"Preferred Plus Sinus Relief",
"Preferred Plus Sinus Relief",
"Preferred Plus Sinus Relief Day Tiime Night Time",
"Preferred Plus Sinus Relief Day Tiime Night Time",
"Prefrin A Liq",
"Prefrin Liq 0.12%",
"Premier Value Chest and Sinus Congestion relief",
"Premier Value day time severe cold and cough berry infused with menthol and green tea flavors",
"Premier Value Hemorrhoidal",
"Premier Value Hemorrhoidal",
"Premier Value Hemorrhoidal",
"Premier Value Hemorrhoidal",
"Premier Value Multi-Symptom Severe Cold Green Tea and Honey Lemon flavors",
"Premier Value Multi-Symptom Severe Cold Green Tea and Honey Lemon flavors",
"Premier Value Multi-Symptom Severe Cold Green Tea and Honey Lemon flavors",
"Premier Value night time severe cold and cough honey lemon infused with chamomile and white tea flavors",
"Premier Value night time severe cold and cough honey lemon infused with chamomile and white tea flavors",
"Preparation H",
"Preparation H",
"Preparation H",
"Preparation H",
"Preparation H",
"Preparation H",
"Preparation H Cooling Gel",
"PREPARATION H Maximum Strength",
"Preparation H Rapid Relief",
"Preparation H Rapid Relief",
"Preparation H Rapid Relief",
"Preparation H Totables Burning Relief",
"Preparation H Totables Pain Relief",
"Preparation H-PE Gel",
"Presgen",
"Presgen B",
"Presgen Pediatric",
"Pressure and Pain",
"Pressure and Pain and Cold",
"Pressure and Pain and Cold",
"Pressure and Pain PE",
"pressure and pain PE",
"Pressure and Pain PE",
"Pressure and Pain PE",
"Pressure and Pain PE Plus Cold",
"Pressure and Pain PE plus Cough",
"Pressure and Pain PE Plus Mucus",
"Pressure and Pain Plus Cold PE",
"Pressure and Pain Plus Cough PE",
"Pressure and Pain Plus Mucus PE",
"pressure and pain sinus relief PE NON-DROWSY",
"Pressure Pain",
"Pressure Pain and Cold Suphedrine PE",
"Pressure Pain Cold",
"Pressure Pain Cold",
"Pressure Pain Cold PE",
"Pressure Pain Cough PE",
"Pressure Pain Mucus",
"Pressure Pain Mucus PE",
"Pressure Pain PE",
"Pressure plus Pain PE",
"Pressure Plus Pain PE",
"Pressure Plus Pain PE Plus Cold",
"Pressure Plus Pain PE Plus Cold",
"Pressure plus Pain PE plus Cough",
"Pressure Plus Pain PE Plus Cough",
"Pressure plus Pain PE plus Mucus",
"Pressure Plus Pain PE Plus Mucus",
"PRESSURE plus PAIN plus MUCUS",
"Pressure plus Pain plus Mucus Non-Drowsy",
"Primary Health - Fast Maximum Cold, Flu and Sore Throat Relief",
"Pro-chlo",
"Pro-red Ac",
"Pro-red Ac",
"Promethazine HCl, Phenylephrine HCl and Codeine Phosphate",
"Promethazine HCl, Phenylephrine HCl, Codeine Phosphate",
"Promethazine Hydrochloride and Phenylephrine Hydrochloride",
"Promethazine Hydrochloride and Phenylephrine Hydrochloride",
"Promethazine Hydrochloride and Phenylephrine Hydrochloride",
"Promethazine hydrochloride and phenylephrine hydrochloride",
"Promethazine Hydrochloride and Phenylephrine Hydrochloride",
"Promethazine Hydrochloride Phenylephrine Hydrochloride and Codeine Phosphate",
"Promethazine Hydrochloride, Phenylephrine Hydrochloride and Codeine Phosphate",
"Promethazine VC",
"Promethazine VC",
"Promethazine VC",
"Promethazine VC",
"Promethazine VC",
"Promethazine Vc",
"Promethazine VC",
"Promethazine VC",
"Promethazine VC With Codeine",
"Promethazine VC With Codeine",
"Promethazine VC With Codeine",
"Promethazine Vc With Codeine",
"Promethazine VC with Codeine",
"Promethazine VC with Codeine",
"Promethazine VC with Codeine Oral Solution",
"Promethazine Vc With Codine",
"Pseudo Time PE",
"PSEUDO-FREE PE Maximum Strength, Non-Drowsy",
"Publix",
"Pulmo Calcio",
"Pulmorphan",
"Pulmorphan Pediatrique",
"Pyrichlor PE",
"Pyril D",
"Pyril DM",
"Pyril Mal Phenyl HCl",
"Pyril Mal Phenyl HCl Dex HBr",
"Pyrilamine Maleate and Phenylephrine Hydrochloride",
"Pyrilamine-Phenylephrine",
"Quality Choice",
"Quality Choice Cold and Sore Throat Lemon Flavor",
"Quality Choice day time severe cold and cough berry infused with menthol and green tea flavors",
"Quality Choice Daytime Severe Cold and Cough Berry infused with Menthol and Green Tea flavors",
"Quality Choice Effervescent Cold Relief - Orange",
"Quality Choice Effervescent Cold Relief Plus",
"Quality Choice Hemorrhoidal",
"Quality Choice Hemorrhoidal",
"Quality Choice Hemorrhoidal",
"Quality Choice Mucus Relief PE PE",
"Quality Choice Multi-Symptom, Non-Drowsy DayTime Cold and Flu",
"Quality Choice night time severe cold and cough honey lemon infused with chamomile and white tea flavors",
"Quality Choice Nighttime Severe Cold and Cough Honey Lemon infused with Chamomile and White Tea Flavors",
"Quality Choice Severe Cold and Cough Nighttime",
"Quartuss",
"Quartuss DM",
"R-Tanna",
"R-Tanna",
"R-Tanna",
"R-Tanna Pediatric Suspension",
"Rapid Action Cold",
"Rapid Max Maximum Strength Cool and Clear - Cold, Flu and Sore throat",
"Rapid Max Maximum Strength Cool and Clear - Cold, Severe Congestion and Cough",
"Rapid Release Multi-Symptom Allergy Relief",
"Ratio-coristex-DH",
"Re Dcp Drops",
"Re Drylex",
"Rectalin Hemorrhoidal Suppositories",
"RectiBiom Hemorrhoid Relief",
"Recticare Advanced",
"Recticare Advanced",
"RectiCare Complete",
"RectiCare Complete",
"Reese ONETAB Congestion and cough",
"Reeses Onetab Allergy and Sinus",
"Reeses Onetab Cold and Flu",
"Refenesen Chest Congestion Relief pe",
"Refenesen Chest Congestion Relief PE",
"Reformulated Rynatan Pediatric",
"Refresh Redness Relief",
"Regular Strength Tylenol Cold Daytime",
"Regular Strength Tylenol Cold Nighttime",
"Regular Strength Tylenol Sinus Daytime",
"RelCof DM",
"RelCof IR",
"Relhist BP",
"Relhist DMX",
"Relief-PE",
"Reme Hist DM",
"Rescon",
"Rescon GG",
"Rescon Jr",
"Rescon MX",
"Revivol Hemorrhoid and Fissure",
"Rexall Daytime Nighttime Cold and Flu",
"Rexall Daytime Nighttime Cold Flu",
"Rexall Hemorrhoidal",
"Rexall Hemorrhoidal",
"Rexall Hemorrhoidal",
"Rexall Hemorrhoidal",
"Rexall Hemorrhoidal Cooling",
"Rexall Hemorrhoidal Cooling",
"Rexall Hemorrhoidal Cooling Gel",
"Rexall Maximum Strength Hemorrhoidal",
"Rexall Maximum Strength Hemorrhoidal",
"Rhume Et De LA Grippe (extra-fort)",
"Rhume Extra Fort Jour",
"Rhume Extra Fort Nuit",
"Rite Aid day time severe cold and cough berry infused with menthol and green tea flavors",
"Rite Aid Daytime Severe Cold and Cough Relief",
"Rite Aid night time severe cold and cough honey lemon with chamomile and white tea flavors",
"Rite Aid Nighttime Severe Cold and Cough Relief",
"Riteaid Hemorrhoidal Cooling",
"Robafen CF Cough and cold",
"Robitussin Children's Cold",
"Robitussin Children's Cough & Cold Bedtime",
"Robitussin Complete Daytime",
"Robitussin Cough and Cold CF",
"Robitussin Cough and Cold CF Max",
"Robitussin Direct Stuffy Nose",
"Robitussin Night Time Cough and Cold",
"Robitussin Night Time Cough, Cold and Flu",
"Robitussin Night Time Cough, Cold and Flu",
"Robitussin Peak Cold Daytime Cold Plus Flu",
"Robitussin Peak Cold Maximum Strength Multi-symptom Cold",
"Robitussin Peak Cold Multi-Symptom Cold",
"Robitussin Peak Cold Nasal Relief",
"Robitussin Peak Cold Nighttime Multi-symptom Cold",
"Robitussin Peak Cold Nighttime Nasal Relief",
"Robitussin Severe Multi-Symptom Cough Cold Flu",
"Robitussin Severe Multi-Symptom Cough Cold Flu Nighttime",
"Robitussin To Go Cough and Cold CF",
"Rompe Pecho CF",
"Rompe Pecho Max Multi Symptoms",
"Rompe Pecho Nighttime",
"Rompe Pecho SF FLU",
"Rompe Tos X Adults",
"Rompe Tos X Children",
"Ru-Hist D",
"Ru-hist Plus",
"Ru-hist-D",
"Ru-hist-D",
"Rugby Chest Congestion Relief PE",
"Rugby Congestion Relief",
"Rugby Hemorrhoidal",
"Rugby Hemorrhoidal",
"Rugby Hemorrhoidal",
"Runny Nose and Cough",
"Runny Nose and Cough",
"Rx Act Cold and Allergy Childrens",
"Rx Act Cold Head Congestion",
"Rx Act Flu and severe cold and cough daytime",
"Rx Act Flu and Severe Cold and Cough Nighttime",
"Rx Act Flu and Sore Throat",
"Rx Act Hemorrhoidal",
"Rx Act Nasal Decongestant PE Non Drowsy Maximum Strength",
"Rx Act nasal four",
"Rx Act sinus and allergy PE",
"Rx Act sinus congestion and pain",
"Rx Act Tussin CF Cough and Cold",
"Rycontuss Cherry Flavor",
"Rymed",
"Ryna -12",
"Ryna -12 S",
"Rynatan",
"Rynatan Chewable Pediatric",
"Rynatuss",
"Rynesa 12S Suspension",
"Rynex DM",
"Rynex PE",
"Safetussin CD",
"Safeway Daytime Cold and Flu Relief",
"Sanaflu Xtra",
"Sanatos",
"SanaTos COLD Multi-Symptom",
"SanaTos COLD Multi-Symptom",
"Sanatos Day",
"SanaTos Day and Night Multi Symptom",
"SanaTos Multi Symptom",
"SanaTos Multi Symptom",
"Sanatos Multi Symptom Daytime",
"SanaTos Severe Cold and Cough Day Time",
"SanaTos Severe Cold and Cough Nighttime",
"SanaTos Turbo Max Strength",
"SanaTos X",
"Scot-Tussin Original Multi-Symptom Cold and Allergy Relief",
"Scot-Tussin Original SF Multi-Symptom",
"Scot-Tussin Original SF Multi-Symptom",
"SECONDARY NUMB Lidocaine Phenylephrine Gel",
"Sedalmex XL Flu",
"Select Brand Hemorrhoid",
"Select Brand Mucus Relief PE",
"Sever Daytime Cold and Flu and Sever Nighttime Cold and Flu",
"Sever Daytime Cold and Flu and Sever Nighttime Cold and Flu",
"Severe Allergy And Sinus Headache",
"Severe Allergy And Sinus Headache Maximum Strength",
"Severe Allergy Plus Sinus Headache",
"Severe Allergy Plus Sinus Headache",
"Severe Allergy Plus Sinus Headache Maximum Strength",
"Severe Allergy Plus Sinus Headache Maximum Strength",
"Severe Allergy Relief Plus Sinus Headache",
"Severe Allergy Relief Plus Sinus Headache",
"Severe Cold",
"Severe Cold",
"Severe Cold",
"Severe Cold",
"Severe Cold",
"Severe Cold",
"Severe Cold",
"Severe Cold",
"Severe Cold",
"Severe Cold and Cough Daytime",
"Severe Cold and Cough Daytime",
"Severe Cold and Cough Daytime",
"Severe Cold and Cough Daytime",
"Severe Cold and Cough Night Time",
"Severe Cold and Cough Nighttime",
"Severe Cold and Cough Nighttime",
"Severe cold and cough relief",
"Severe Cold and Cough Relief Daytime",
"Severe Cold and Cough Relief Daytime",
"Severe Cold and Cough Relief Daytime",
"Severe Cold and Cough Relief Daytime",
"Severe Cold and Cough Relief Daytime",
"Severe Cold and Cough Relief Daytime",
"Severe Cold and Cough Relief Daytime",
"Severe Cold and Cough Relief Daytime",
"Severe Cold and Cough Relief Nighttime",
"Severe Cold and Cough Relief Nighttime",
"Severe Cold and Cough Relief Nighttime",
"Severe Cold and Flu",
"Severe Cold and Flu",
"Severe Cold and Flu",
"Severe Cold and Flu",
"Severe Cold and Flu",
"Severe Cold and Flu",
"Severe Cold and Flu",
"Severe Cold and Flu",
"Severe Cold and Flu",
"Severe Cold and Flu",
"Severe Cold and Flu",
"Severe Cold and Flu",
"Severe Cold and Flu",
"Severe Cold and Flu",
"Severe Cold and Flu",
"Severe Cold and Flu",
"Severe Cold and Flu",
"Severe Cold and Flu",
"Severe Cold and Flu",
"Severe Cold and Flu",
"Severe Cold and Flu",
"Severe Cold and Flu",
"Severe Cold and Flu",
"Severe Cold and Flu",
"Severe Cold and Flu Daytime",
"SEVERE COLD AND FLU DAYTIME NON DROWSY and NIGHTTIME",
"SEVERE COLD AND FLU DAYTIME NON DROWSY and NIGHTTIME",
"SEVERE COLD AND FLU DAYTIME NON DROWSY and NIGHTTIME",
"SEVERE COLD AND FLU DAYTIME NON DROWSY and NIGHTTIME",
"Severe Cold and Flu Daytime Non Drowsy Nighttime",
"Severe Cold and Flu Daytime Non Drowsy Nighttime",
"Severe Cold and Flu Daytime Non Drowsy Nighttime",
"Severe Cold and Flu Daytime Non Drowsy Nighttime",
"Severe Cold and Flu Daytime Non Drowsy Nighttime",
"Severe Cold and Flu Daytime Non Drowsy Nighttime",
"Severe Cold and Flu Daytime Non Drowsy Nighttime",
"Severe Cold and Flu Daytime Non Drowsy Nighttime",
"Severe Cold and Flu Daytime/nighttime",
"Severe Cold and Flu Daytime/nighttime",
"Severe Cold and Flu Maximum Strength, Daytime, Non-Drowsy",
"Severe Cold and Flu Night time",
"Severe cold and flu Nighttime",
"Severe Cold and Flu nighttime",
"Severe cold and flu Nighttime",
"Severe cold and flu Nighttime",
"Severe cold and flu Nighttime",
"Severe Cold and Flu Nighttime Daytime",
"Severe Cold and Flu Nighttime Daytime",
"Severe Cold and Flu Plus Congestion",
"Severe Cold and Flu Plus Congestion",
"Severe Cold and Flu Relief",
"Severe Cold and Flu Relief",
"Severe Cold and Flu Relief",
"Severe Cold and Flu Relief",
"Severe Cold and Flu Relief",
"Severe Cold and Flu Relief",
"Severe Cold and Flu Relief",
"Severe Cold and Flu Relief Daytime",
"Severe Cold and Flu Relief Daytime",
"Severe Cold and Flu Relief Daytime",
"Severe Cold and Flu Relief Daytime",
"Severe Cold and Flu Relief Daytime",
"Severe Cold and Flu Relief Daytime/Nighttime",
"Severe Cold and Flu Relief Daytime/Nighttime",
"Severe Cold and Flu Relief Daytime/Nighttime",
"Severe Cold and Flu Relief Daytime/Nighttime",
"Severe Cold and Flu Relief Nighttime",
"Severe Cold and Mucus",
"Severe Cold and Mucus",
"severe cold and sinus relief PE",
"Severe Cold Cough and Flu",
"Severe Cold Cough and Flu",
"Severe Cold Cough and Flu",
"Severe Cold Cough and Flu Relief Daytime",
"Severe Cold Cough and Flu Relief Nighttime",
"SEVERE COLD DAY COLD and FLU NIGHT",
"SEVERE COLD DAY COLD and FLU NIGHT",
"Severe Cold Daytime",
"Severe Cold Daytime",
"Severe Cold Daytime",
"Severe Cold Daytime Cold and Flu Nighttime",
"Severe Cold Daytime Cold and Flu Nighttime",
"Severe Cold Daytime Multi-Symptom Non-Drowsy",
"Severe Cold DM",
"Severe Cold DM Severe Cold and Flu",
"Severe Cold DM Severe Cold and Flu",
"Severe Cold Head Congestion",
"Severe Cold Head Congestion",
"Severe Cold Head Congestion",
"Severe Cold Head Congestion",
"Severe Cold Maximum Strength, Multi-Symptom",
"Severe Cold Multi Symptom",
"Severe Cold Multi Symptom",
"Severe Cold Multi Symptom",
"Severe Cold Multi-Symptom",
"Severe Cold PE",
"Severe Cold PE",
"Severe Cold PE Multi-Symptom",
"Severe Cold Plus Flu Daytime Nighttime",
"Severe Cold Plus Flu Daytime Nighttime",
"Severe Cold Relief",
"Severe Cold Relief PE",
"Severe Cold Relief PE",
"Severe Cold, Cold and Flu Daytime, Nighttime, Maximum Strength",
"Severe Cold, Cold and Flu Daytime, Nighttime, Maximum Strength",
"severe cold, cold and flu Daytime/Nighttime",
"severe cold, cold and flu Daytime/Nighttime",
"Severe Cold, Cold and Flu Maximum Strength, Daytime, Nightime",
"Severe Cold, Cold and Flu Maximum Strength, Daytime, Nightime",
"Severe Cold, Cold and Flu Maximum Strength, Daytime, Nightime",
"Severe Cold, Cold and Flu Maximum Strength, Daytime, Nightime",
"Severe Cold, Flu and Cough",
"Severe Congestion",
"Severe Congestion and Cold Maximum Strength",
"Severe Congestion and Cold Maximum Strength/ Multi-Symptom",
"Severe Congestion and Cold Relief Maximum Strength, Multi Symptom",
"Severe Congestion and Cough",
"Severe Congestion and Cough MAX Maxium Strength",
"Severe Congestion and Cough Multi-Symptom Maximum Strength",
"Severe Congestion and Cough Relief",
"Severe Congestion and Cough Relief",
"Severe Congestion and Cough Relief Maximum Strength",
"Severe Congestion and Cough, Cold and Flu Daytime and Nighttime",
"Severe Congestion and Cough, Cold and Flu Daytime and Nighttime",
"Severe Congestion and Cough, Cold and Flu Daytime, Nighttime",
"Severe Congestion and Cough, Cold and Flu Daytime, Nighttime",
"Severe Congestion and Cough, Cold and Flu Daytime, Nighttime",
"Severe Congestion and Cough, Cold and Flu Daytime, Nighttime",
"Severe Congestion and Cough, Cold and Flu Daytime, Nighttime",
"Severe Congestion and Cough/ Cold and Flu Daytime/nighttime",
"Severe Congestion and Cough/ Cold and Flu Daytime/nighttime",
"Severe Congestion and Cough/Cold and Flu Daytime/Nighttime/Maximum Strength",
"Severe Congestion and Cough/Cold and Flu Daytime/Nighttime/Maximum Strength",
"Severe Congestion and Pain",
"Severe Congestion and Sinus Relief Maximum Strength",
"Severe Congestion Relief",
"Severe Congestion Relief Maximum Strength Sinus",
"Severe Congestion, Cough, Cold and Flu Relief Maximum Strength, Nighttime",
"Severe Cough and Cold",
"Severe Cough and Cold",
"Severe Cough and Congestion",
"Severe Cough and Congestion",
"Severe Cough and Congestion",
"Severe Cough and Congestion and Cold and Flu Daytime, Nighttime",
"Severe Cough and Congestion and Cold and Flu Daytime, Nighttime",
"Severe Cough and Congestion Maximum Strength",
"Severe Daytime",
"Severe Daytime",
"SEVERE DAYTIME COLD and FLU DAYTIME MAXIMUM STRENGTH NON-DROWSY SEVERE",
"Severe DayTime NightTime Cold and Flu Relief Max Strength",
"Severe DayTime NightTime Cold and Flu Relief Max Strength",
"Severe Multi-Symptom Cold",
"Severe Nighttime",
"Severe Nighttime Cold and Flu",
"Severe Nighttime Cold and Flu",
"Severe Nighttime Cold and Flu",
"Severe Nighttime Cold and Flu",
"Severe Nighttime Cold and Flu",
"Severe Nighttime Cold and Flu",
"Severe Nighttime Cold and Flu",
"Severe Nighttime Cold and Flu",
"Severe Nighttime Cold and Flu Relief",
"Severe Nighttime Severe Daytime",
"Severe Nighttime Severe Daytime",
"Severe Sinus",
"Severe Sinus",
"Severe Sinus Congestion",
"Severe Sinus Congestion",
"Severe Sinus Congestion",
"Severe Sinus Congestion Allergy and Cough Formula",
"Severe Sinus Congestion Allergy and Cough Formula",
"Severe Sinus Congestion and Cough Daytime Non-drowsy / Nightime",
"Severe Sinus Congestion and Cough Daytime Non-drowsy / Nightime",
"Severe Sinus Congestion and Pain",
"Severe Sinus Congestion and Pain",
"Severe Sinus Congestion and Pain Daytime",
"Severe Sinus Congestion and Pain Daytime",
"Severe Sinus Congestion and Pain Maximum Strength",
"Severe Sinus Congestion and Pain Non-Drowsy, Daytime",
"Severe Sinus Congestion Relief",
"Severe sinus Congestion Relief",
"Severe sinus Congestion Relief",
"Severe sinus Congestion Relief",
"Severe sinus Congestion Relief",
"Severe sinus Congestion Relief",
"Severe sinus Congestion Relief",
"severe sinus congestion relief Maximum Strength",
"Severe Sinus Daytime, Non-Drowsy",
"Severe Sinus Pain and Congestion Daytime",
"Severe Tussin CF",
"Severe Tussin CF",
"Severe Vapor Ice Cold and Flu Relief",
"Severe Wal Tussin CF Max",
"shop rite Day Severe Cold Night Cold and Flu",
"shop rite Day Severe Cold Night Cold and Flu",
"Shopko Hemorrhoidal",
"Shopko Hemorrhoidal",
"ShopRight Childrens Nighttime Cold and Cough",
"ShopRite Adult Tussin",
"ShopRite Adult Tussin",
"ShopRite Allergy",
"ShopRite Childrens Cold and Allergy",
"ShopRite Childrens Cold and Cough",
"ShopRite Childrens Multi Symptom Cold Relief",
"ShopRite Cold Multi Symptom",
"Shoprite Congestion and Pain",
"ShopRite Day Calm",
"ShopRite Day Calm",
"Shoprite Day Calm Severe",
"ShopRite Day Calm Severe",
"ShopRite DayTime Flu Plus Severe Cold And Cough",
"ShopRite Hemorrhoidal",
"Shoprite Hemorrhoidal",
"ShopRite Nasal Decongestant PE",
"Shoprite Nasal Four",
"Shoprite Ni Calm",
"ShopRite Nighttime Flu Plus Severe Cold and Cough",
"ShopRite Severe Cold",
"Shoprite Sinus Congestion and Pain",
"Signature Care Childrens Cold and Cough",
"Signature Care Childrens Multi Symptom Cold",
"Signature Care daytime nighttime severe cold and flu relief",
"Signature Care daytime nighttime severe cold and flu relief",
"Signature Care Daytime Severe Cold",
"Signature Care Daytime Severe Cold and Flu Relief",
"Signature Care Hemorrhoidal",
"Signature Care Hemorrhoidal",
"Signature Care Hemorrhoidal",
"Signature Care Hemorrhoidal",
"Signature Care Hemorrhoidal Cream (with applicator)",
"Signature Care Nighttime Severe Cold and Flu Relief",
"Signature Care Nighttime Severe Cold and Flu Relief",
"Signature Care Non drowsy Daytime Severe Cold and Flu Relief",
"Signature Care severe cold cough and flu Nighttime",
"Sildec PE",
"Sildec PE DM",
"Sildec PE DM",
"Sildec PE DM",
"SIMPLE PROMISE Simple H Hemorrhoid Relief Cream",
"SIMPLE PROMISE Simple H Hemorrhoid Relief Cream",
"Sine Off Maximum Strength",
"Sine Off Sinus/cold Medicine",
"Sine-EEz",
"Sinex",
"Sinex",
"Sinex",
"Sinex Congestion & Headache",
"Sinex Nighttime Sinus",
"Sinex Severe plus Vicks VapoCool",
"Sinex Severe plus Vicks VapoCool",
"Sinu-Phen",
"Sinu-Phen Plus",
"Sinus",
"Sinus",
"Sinus",
"Sinus",
"Sinus",
"Sinus and Allergy",
"Sinus and Allergy",
"Sinus and Allergy",
"Sinus and Allergy",
"Sinus and Allergy",
"Sinus and Allergy Maximum Strength",
"Sinus and Allergy Maximum Strength",
"Sinus and Allergy PE",
"Sinus and Allergy PE",
"Sinus and Allergy PE",
"Sinus and Allergy PE",
"Sinus and Allergy PE",
"Sinus and Allergy PE Maximum Strength",
"Sinus and Allergy PE Maximum Strength",
"Sinus and Allergy PE Maximum Strength",
"Sinus and Allergy PE maximum strength",
"Sinus and Allergy PE Maximum Strength",
"Sinus and Allergy Releif PE",
"Sinus and Allergy Relief",
"Sinus and Allergy Relief",
"Sinus and Allergy Relief PE",
"Sinus and Allergy Relief PE",
"Sinus and Congestion Relief Daytime",
"Sinus and Headache",
"Sinus and Headache",
"Sinus and Headache",
"Sinus and Headache",
"Sinus and Headache",
"Sinus and Headache",
"Sinus and Headache",
"Sinus and Headache",
"Sinus and Headache",
"Sinus and Headache",
"Sinus and Headache",
"Sinus and Headache Day Night",
"Sinus and Headache Day Night",
"Sinus and Headache Day Night",
"Sinus and Headache Day Night",
"Sinus and Headache Daytime",
"Sinus and Headache Daytime",
"Sinus and Headache Daytime Non-Drowsy",
"Sinus and Headache Daytime, Non-Drowsy",
"Sinus and Headache Daytime, Non-Drowsy",
"Sinus Congestion",
"Sinus Congestion",
"Sinus Congestion",
"Sinus Congestion",
"Sinus Congestion and Pain",
"Sinus Congestion and Pain",
"Sinus Congestion and Pain",
"Sinus Congestion and Pain",
"Sinus Congestion and Pain",
"Sinus Congestion and Pain",
"Sinus Congestion and Pain",
"Sinus Congestion and Pain",
"Sinus Congestion and Pain",
"Sinus Congestion and Pain",
"Sinus Congestion and Pain",
"Sinus Congestion and Pain",
"Sinus Congestion and Pain",
"Sinus Congestion and Pain",
"Sinus Congestion and Pain",
"Sinus Congestion and Pain",
"Sinus Congestion and Pain Day, Non-Drowsy",
"Sinus Congestion and Pain Daytime",
"Sinus Congestion and Pain Daytime",
"Sinus Congestion And Pain Daytime",
"Sinus Congestion and Pain Daytime",
"Sinus Congestion and Pain Daytime",
"Sinus Congestion and Pain Daytime",
"Sinus Congestion and Pain Daytime",
"Sinus Congestion and Pain Daytime Nighttime",
"Sinus Congestion and Pain Daytime Nighttime",
"Sinus Congestion and Pain Daytime Nighttime",
"Sinus Congestion and Pain Daytime Nighttime",
"Sinus Congestion and Pain daytime nighttime",
"Sinus Congestion and Pain daytime nighttime",
"Sinus Congestion and Pain Daytime Non Drowsy",
"Sinus Congestion and Pain Daytime Non-Drowsy",
"Sinus Congestion and Pain Daytime Non-Drowsy Severe",
"Sinus Congestion and Pain Daytime, Non-drowsy",
"Sinus Congestion and Pain Daytime/Nighttime",
"Sinus Congestion and Pain Daytime/Nighttime",
"Sinus Congestion and Pain Maximum Strength",
"Sinus Congestion and Pain Nighttime",
"Sinus Congestion and Pain Non Drowsy",
"Sinus Congestion and Pain Non-Drowsy",
"Sinus Congestion and Pain Non-Drowsy",
"Sinus Congestion and Pain Non-Drowsy, Daytime",
"Sinus Congestion and Pain Relief",
"Sinus Congestion and Pain Relief",
"Sinus Congestion and Pain Relief Non-Drowsy",
"Sinus Congestion and Pain Relief Non-Drowsy",
"Sinus Congestion and Pain Relief Non-Drowsy, Daytime",
"Sinus Congestion and Pain Relief Non-Drowsy/Daytime",
"Sinus Congestion and Pain Severe",
"Sinus Congestion and Pain Severe",
"Sinus Congestion and Pain Severe",
"Sinus Congestion and Pain Severe",
"Sinus Congestion and Pain Severe",
"Sinus Congestion and Pain Severe",
"Sinus Congestion and Pain Severe",
"Sinus Congestion and Pain Severe",
"Sinus Congestion and Pain Severe Daytime,Non-Drowsy",
"Sinus Congestion PE",
"Sinus Congestion PE",
"Sinus Congestion PE",
"Sinus Congestion PE",
"Sinus Congestion PE",
"Sinus Congestion PE",
"Sinus Congestion PE Maximum Strength",
"Sinus Congestion Relief",
"Sinus Daytime",
"Sinus Decongestant",
"Sinus Extra Fort Jour",
"Sinus Extra Fort Nuit",
"Sinus Headache",
"Sinus Headache",
"Sinus Headache and Pain Day, Non-drowsy",
"Sinus Headache Day Night",
"Sinus Headache Day Night",
"Sinus Headache Maximum Strength",
"Sinus Headache PE",
"Sinus Headache PE Maximum Strength",
"Sinus Headache PE Non- Drowsy Maximum Strength",
"Sinus Headache PEMaximum Strength Non-Drowsy Maximum Strength Non-Drowsy",
"Sinus Max Relief Day and Night",
"Sinus Max Relief Day and Night",
"Sinus Medication",
"Sinus Medication Day Regular Tablets PE",
"Sinus Nighttime",
"Sinus Pain",
"Sinus Pain and Congestion",
"Sinus Pain and Congestion",
"Sinus Pain and Congestion",
"Sinus Pain and Congestion Daytime",
"Sinus Pain and Congestion Daytime",
"SINUS PAIN AND CONGESTION Nighttime",
"sinus PE",
"sinus PE",
"Sinus PE and Allergy",
"Sinus PE Congestion",
"Sinus PE Congestion",
"Sinus PE Congestion Daytime Nighttime",
"Sinus PE Congestion Daytime Nighttime",
"Sinus PE Decongestant",
"Sinus PE Decongestant Maximum Strength",
"Sinus PE Head Congestion and Flu Severe",
"Sinus PE Head Congestion and Mucus",
"Sinus PE plus Allergy",
"Sinus PE plus Allergy Maximum Strength",
"Sinus PE Pressure plus Pain MAXIMUM STRENGTH",
"Sinus PE Pressure, Pain and Cold Daytime, Non-Drowsy",
"Sinus PE Pressure, Pain and Mucus",
"Sinus PE Pressure, Pain and Mucus",
"Sinus PE Pressure, Pain plus Cough Multi-Symptom",
"sinus plus allergy PE maximum strength",
"Sinus plus Headache",
"Sinus Plus Headache",
"Sinus plus Headache",
"Sinus plus Headache",
"Sinus Plus Headache",
"Sinus plus Headache",
"Sinus plus Headache",
"Sinus Plus Headache Day and Night",
"Sinus Plus Headache Day and Night",
"Sinus plus Headache Day and Night",
"Sinus plus Headache Day and Night",
"Sinus plus Headache Daytime and Nighttime",
"Sinus plus Headache Daytime and Nighttime",
"Sinus Pressure and Congestion Relief",
"Sinus Pressure and Congestion Relief",
"Sinus Pressure and Congestion Relief PE Maximum Strength",
"Sinus Pressure and Pain",
"Sinus Pressure and Pain",
"Sinus Pressure and Pain",
"Sinus Pressure and Pain and Cough",
"Sinus Pressure and Pain Daytime Nighttime Maximum Strength",
"Sinus Pressure and Pain Daytime Nighttime Maximum Strength",
"Sinus Pressure and Pain Maximum Strength",
"Sinus Pressure and Pain Maximum Strength",
"Sinus Pressure and Pain Maximum Strength",
"Sinus Pressure and Pain PE",
"sinus pressure and pain PE",
"Sinus Pressure and Pain PE Maximum Strength",
"Sinus Pressure and Pain Relief maximum strength",
"SINUS PRESSURE Maximum Strength",
"Sinus Pressure Pain and Cough",
"Sinus Pressure Pain Maximum Strength, Non-Drowsy",
"Sinus Pressure plus Pain",
"Sinus Pressure plus Pain PE",
"Sinus Pressure plus Pain PE",
"Sinus Pressure plus Pain PE",
"Sinus Pressure plus Pain PE",
"Sinus Pressure plus Pain PE",
"Sinus Pressure, Pain and Cough",
"Sinus Pressure, Pain and Cough",
"Sinus Relief",
"Sinus Relief",
"Sinus Relief",
"Sinus Relief",
"Sinus Relief",
"Sinus Relief",
"Sinus Relief",
"Sinus Relief",
"Sinus Relief",
"Sinus Relief",
"Sinus Relief Congestion and Cough Maximum Strength",
"Sinus Relief Congestion and Cough Maximum Strength",
"Sinus Relief Congestion and Pain - Daytime and Nighttime",
"Sinus Relief Congestion and Pain - Daytime and Nighttime",
"Sinus Relief Congestion and Pain Daytime",
"Sinus Relief Congestion and Pain Nighttime",
"Sinus Relief Congestion and Pain Severe",
"Sinus Relief Day and Night",
"Sinus Relief Day and Night",
"Sinus Relief Day Night",
"Sinus Relief Day Night",
"Sinus Relief Day Night",
"Sinus Relief Day Night",
"Sinus Relief Daytime",
"Sinus Relief Daytime Nighttime",
"Sinus Relief Daytime Nighttime",
"Sinus Relief Daytime Nighttime",
"Sinus Relief Daytime Nighttime",
"Sinus Relief Daytime, Nighttime",
"Sinus Relief Daytime, Nighttime",
"Sinus Relief Daytime, Nighttime, Maximum Strength",
"Sinus Relief Daytime, Nighttime, Maximum Strength",
"Sinus Relief Headache Nasal",
"Sinus Relief MAXIMUM STRENGTH",
"Sinus Relief Maximum Strength",
"Sinus Relief Maximum Strength",
"SINUS RELIEF Maximum Strength Daytime and Nighttime Sinus Pain",
"SINUS RELIEF Maximum Strength Daytime and Nighttime Sinus Pain",
"Sinus Relief Non Drowsy",
"Sinus Relief Non Drowsy",
"Sinus Relief Non-Drowsy Daytime",
"Sinus Relief PE Maximum Strength",
"Sinus Relief Pressure and Pain",
"Sinus Relief Pressure, Pain and Cough",
"Sinus Relief Severe Congestion",
"Sinus Relief Severe Congestion and Pain",
"Sinus Relief Severe Congestion Maximum Strength",
"Sinus Relief Severe Congestion Maximum Strength",
"Sinus Relief Severe Congestion Maximum Strength",
"Sinus Relief, Caseys 4good",
"Sinus Severe",
"Sinus Severe",
"Sinus Severe",
"Sinus Severe",
"Sinus Severe",
"Sinus Severe",
"Sinus Severe",
"Sinus Severe",
"Sinus Severe",
"Sinus Severe",
"Sinus Severe",
"Sinus Severe",
"Sinus Severe",
"Sinus Severe",
"Sinus Severe Cold Multi-Symptom",
"Sinus Severe Daytime",
"Sinus Sevre",
"Sinutab PE Extra Strength",
"Sinutab PE Nd Extra Strength",
"Sinutab PE Nd Regular Strength",
"Sinutab PE Nightime",
"Sinutab PE Sinus and Allergy",
"Sinutab Sinus MAXIMUM STRENGTH",
"Skopko Chest Congestion Relief PE PE",
"Smart Sense Adults Tussin CF Multi Symptom Cold",
"Smart Sense Childrens Multi Symptom Cold Relief",
"Smart Sense Childrens Nighttime Cold and Cough",
"Smart Sense Cold and Allergy Childrens",
"Smart Sense Cold and Cough",
"Smart Sense cold flu and sore throat",
"Smart Sense DayTime",
"Smart Sense Daytime",
"Smart Sense daytime cold and flu",
"Smart Sense Daytime Nighttime Cold and Flu",
"Smart Sense Daytime Nighttime Cold and Flu",
"Smart Sense Daytime Nighttime Cold and Flu",
"Smart Sense Effervescent Cold Relief",
"Smart Sense Flu and Severe Cold and Cough Daytime",
"Smart Sense Flu and Severe Cold and Cough Nighttime",
"Smart Sense Hemorrhoidal",
"Smart Sense Hemorrhoidal",
"Smart Sense Hemorrhoidal",
"Smart Sense Hemorrhoidal",
"Smart Sense Hemorrhoidal",
"Smart Sense Hemorrhoidal",
"Smart Sense Multi Symptom Cold",
"Smart Sense Multi Symptom Cold",
"Smart Sense Multi Symptom Fever and Cold Childrens",
"Smart Sense nasal decongestant pe maximum strength",
"Smart Sense nighttime cold and flu",
"Smart Sense NightTime DayTime",
"Smart sense Nighttime Severe Cold and Cough Honey Lemon infused with Chamomile and White Tea Flavors",
"Smart Sense Severe Cold",
"Smart Sense Severe Cold and Flu NightTime",
"Smart Sense Sinus",
"Smart Sense Sinus",
"Smart Sense Sinus",
"Smart Sense Sinus and Headache",
"Smart Sense Sinus PE",
"Smart Sense sinus plus headache",
"Smart Sense sinus plus headache",
"Smart Sense Sinus Relief",
"Smart Sense Sinus Relief",
"Smart Sense Sinus Relief",
"Smart Sense Triacting",
"Smart Sense Tussin CF Adult",
"SMITH BROS NIGHT TIME COUGH and CONGESTION",
"SMITH BROS NON-DROWSY DAY TIME COLD and FLU",
"SMITH BROS NON-DROWSY MULTI-SYMPTOM COLD and FLU",
"Soframycin Nasal Spray",
"Soframycin Nasal Spray",
"Soframycin Nasal Spray",
"SohMed Allergy Sinus",
"SohMed Cold Relief",
"SohMed Sinus",
"Sonahist",
"Sonahist DM",
"Sore Throat & Cold Powder Night",
"Sound Body Cold and Flu Relief",
"Sound Body Cold and Flu Relief DayTime",
"Sound Body Daytime Cold and Flu Relief Nighttime Cold and Flu Relief",
"Sound Body Daytime Cold and Flu Relief Nighttime Cold and Flu Relief",
"Sound Body Severe Cold and Flu",
"Sound Body Tussin CF",
"Stahist Tp",
"Stona",
"Stona Cough",
"Stona-S",
"Stonarhini",
"SU PHEDRINE PE Non-Drowsy, Maximum Strength",
"Sudafed PE Cold and Cough",
"Sudafed PE Cold and Flu Caplets",
"Sudafed PE Congestion",
"Sudafed PE Day Plus Night Sinus Congestion",
"Sudafed PE Day Plus Night Sinus Congestion",
"Sudafed PE Extra Strength",
"Sudafed PE Head Cold & Sinus",
"SUDAFED PE Head Congestion Plus Flu Severe",
"SUDAFED PE Head Congestion Plus Mucus",
"Sudafed PE Head Congestion Plus Pain",
"Sudafed PE Non-Drowsy Sinus Headache MAXIMUM STRENGTH",
"SUDAFED PE Pressure Plus Pain",
"Sudafed PE Pressure Plus Pain Plus Cold",
"Sudafed PE Pressure plus Pain plus Cough",
"Sudafed PE Pressure Plus Pain Plus Cough Day",
"SUDAFED PE Pressure PLUS Pain PLUS Mucus",
"Sudafed PE Regular Strength",
"Sudafed PE Sinus Congestion",
"Sudafed PE Sinus Congestion",
"Sudafed PE Sinus Congestion",
"Sudafed PE Sinus Pressure Plus Pain",
"Sudafed PE Total",
"Sudafed Total Cold and Flu Rapid Release",
"Sudo-Tab PE",
"Sudogest PE",
"Sudogest PE",
"Sudogest PE",
"Sunmark Allergy Multi Symptom",
"Sunmark Chest Congestion Relief PE PE",
"sunmark Cold",
"Sunmark Cold and Allergy",
"Sunmark Cold and Allergy Childrens",
"Sunmark Cold and Allergy Childrens",
"Sunmark Cold and Cough DM Childrens",
"Sunmark Cold and Flu Severe",
"Sunmark Cold Head Congestion",
"Sunmark cold head congestion",
"Sunmark Day Time Cold and Cough Childrens Triacting Formula",
"Sunmark Day time cold and flu",
"Sunmark Hemorrhoidal",
"Sunmark Hemorrhoidal",
"Sunmark Hemorrhoidal",
"Sunmark Hemorrhoidal",
"Sunmark Nasal Decongestant PE Maximum Strength",
"Sunmark Nasal Fast Relief",
"Sunmark Nose",
"Sunmark Severe Day Time",
"Sunmark Severe Nite Time Cold and Flu",
"Sunmark Sinus and Allergy PE Maximum Strength",
"Sunmark sinus congestion and pain",
"Sunmark Tussin CF",
"Super Strength Cold & Congestion Powder",
"Super Strength Complete Cold Powder",
"Super Strength Contac Cold & Sinus Hot Medicated Drink",
"Super Strength Sore Throat & Cold Powder",
"Suphedrine PE",
"Suphedrine PE",
"Suphedrine PE",
"Suphedrine PE",
"Suphedrine PE",
"Suphedrine PE",
"Suphedrine PE",
"Suphedrine PE",
"Suphedrine PE",
"Suphedrine PE",
"Suphedrine PE",
"Suphedrine PE Congestion",
"Suphedrine PE Congestion Non-Drowsy",
"Suphedrine PE Pressure plus Pain Maximum Strength, Non-Drowsy",
"Suphedrine PE Sinus Congestion Non-Drowsy",
"Suphedrine PE Sinus plus Allergy",
"Suphedrine PE Sinus Pressure Plus Pain",
"Supress A",
"Supress DX Pediatric Drops",
"SUPRESS-PE Pediatric",
"Swift Sinus Pain",
"Tabcin 500",
"Tabcin 500",
"Tabcin Extra Strength",
"Tannate",
"Tannate",
"Tantapp Elixir",
"Target Maximum Strength Cold Flu and Sore Throat",
"Target Maximum Strength Cold Flu and Sore Throat Overnight Cold and Flu",
"Tenalif Children",
"Tenalif Multi Symptom Relief",
"Terpacan",
"Texaclear Congestion and Pain Sinus Relief",
"Texaclear Daytime Cough Cold/flu",
"TexaClear Kids Cold Relief",
"TexaClear Kids Congestion Stuffy Nose",
"TexaClear Kids Cough and Cold",
"TexaClear Kids Sinus Relief",
"Texaclear Night Time Cough Cold/flu",
"TheraCare Hemorrhoidal",
"TheraFlu Cold and Flu",
"TheraFlu Cold and Flu",
"TheraFlu Cold and Flu",
"Theraflu Cold and Sore Throat",
"Theraflu Daytime Cold and Flu",
"Theraflu Daytime Severe Cold and Cough",
"Theraflu Daytime Severe Cold and Cough",
"Theraflu Daytime Severe Cold and Cough",
"Theraflu ExpressMax Daytime Nighttime Value Pack",
"Theraflu ExpressMax Daytime Nighttime Value Pack",
"Theraflu ExpressMax Daytime Severe Cold and Cough",
"Theraflu ExpressMax Daytime Severe Cold and Cough",
"Theraflu Expressmax Daytime Severe Cold and Cough and Theraflu Expressmax Nighttime Severe Cold and Cough",
"Theraflu Expressmax Daytime Severe Cold and Cough and Theraflu Expressmax Nighttime Severe Cold and Cough",
"Theraflu ExpressMax Flu, Cough, and Sore Throat",
"Theraflu ExpressMax Nighttime Severe Cold and Cough",
"Theraflu ExpressMax Nighttime Severe Cold and Cough",
"Theraflu ExpressMax Severe Cold and Flu Caplets",
"Theraflu ExpressMax Severe Cold and Flu Syrup",
"Theraflu Flu and Sore Throat",
"Theraflu Multi-symptom Severe Cold",
"Theraflu Multi-Symptom Severe Cold and Theraflu Nighttime Severe Cold and Cough",
"Theraflu Multi-Symptom Severe Cold and Theraflu Nighttime Severe Cold and Cough",
"Theraflu Multi-Symptom Severe Cold and Theraflu Nighttime Severe Cold and Cough",
"Theraflu Multi-Symptom Severe Cold and Theraflu Nighttime Severe Cold and Cough",
"Theraflu Nighttime Cold and Flu",
"Theraflu Nighttime Multi-Symptom Severe Cold Powder",
"Theraflu Nighttime Severe Cold and Cough",
"Theraflu Nighttime Severe Cold and Cough",
"Theraflu Nighttime Severe Cold and Cough",
"Theraflu PowerPods Daytime Severe Cold",
"Theraflu Powerpods Nighttime Severe Cold",
"Theraflu Severe Cold Relief Daytime and Theraflu Severe Cold Relief Nighttime",
"Theraflu Severe Cold Relief Daytime and Theraflu Severe Cold Relief Nighttime",
"Theraflu Severe Cold Relief Daytime with Honey Ginger Flavor",
"Theraflu Severe Cold relief Nighttime",
"Theraflu Severe Cold relief Nighttime",
"Theraflu Severe Cold Relief Nighttime with Honey Elderberry Flavor",
"Theraflu Sinus and Cold",
"Theraflu Sinus and Pain",
"Theraflu Sugar Free Nightime Severe Cold and Cough",
"Theraflu Warming Relief Cold and Chest Congestion",
"Theraflu Warming Relief Daytime Multi-Symptom Cold Caplets",
"Theraflu Warming Relief Daytime Severe Cold And Cough",
"Theraflu Warming Relief Flu and Sore Throat",
"Theraflu Warming Relief Nighttime Multi-Symptom Cold Caplets",
"Theraflu Warming Relief Nighttime Severe Cold And Cough",
"TheraPlus Plus",
"Thompson Cough and Cold Multi-Symptom Relief",
"Tl-hist CD",
"Tl-hist DM",
"Tl-hist DM",
"Toa Syrup Adult",
"Top Care Day Time Multi Symptom Relief",
"Top Care Flu and Sore Throat",
"Top Value Effervescent Cold Relief",
"Top Value Effervescent Cold Relief - Orange",
"Topcare Allergy Multi Symptom",
"Topcare Chest Congestion and Sinus Congestion Relief PE",
"Topcare Childrens Cold and Allergy",
"Topcare childrens cold and cough",
"Topcare Childrens Cold and Flu",
"Topcare Childrens Mucus Relief Multi Symptom Cold",
"Topcare Childrens Night Time Cold and Cough",
"Topcare Childrens Triacting Nightime Cold and Cough",
"Topcare Clear Time",
"Topcare Clear Time",
"Topcare Cold",
"Topcare Cold",
"Topcare Cold",
"Topcare Cold",
"Topcare Cold and Allergy",
"Topcare Cold and Cough",
"Topcare Cold and Flu",
"Topcare Cold and Flu",
"Topcare Cold and Flu",
"Topcare Cold and Flu Night Time",
"TopCare Cold and Sore Throat Lemon Flavor",
"Topcare Cold and Sore Throat Lemon Flavor",
"Topcare Cold Head Congestion",
"Topcare Cold Head Congestion Nighttime",
"Topcare Cold Head Congestion Severe",
"TopCare Cold Max",
"Topcare Cold Multi Symptom",
"Topcare Cold Multi Symptom Severe",
"TopCare Cold NightTime Multi Symptom",
"Topcare Congestion Relief",
"Topcare Cough Cold and Flu Simple Relief",
"Topcare Day Night",
"Topcare Day Night",
"Topcare Day Time",
"Topcare Day Time Cold and Flu",
"Topcare Day Time Cold and Flu",
"Topcare Day Time Cold and Flu",
"Topcare Day Time Cold and Flu",
"Topcare Day Time Cold and Flu",
"Topcare Day time cold and flu relief",
"Topcare Day Time Cold and Flu Relief Multi Symptom Relief",
"Topcare Day Time Cold and Flu Severe",
"Topcare Day Time Nite Time",
"Topcare Day Time Nite Time",
"Topcare Day Time Nite Time Cold and Flu",
"Topcare Day Time Nite Time Cold and Flu",
"Topcare Day Time Nite Time Cold and Flu",
"Topcare Day Time Nite Time Cold and Flu",
"Topcare Day Time Nite Time Cold and Flu",
"Topcare Day Time Nite Time Cold and Flu",
"Topcare Day Time Nite Time Cold and Flu",
"Topcare Day Time Nite Time Cold and Flu",
"Topcare Day Time Nite Time Cold and Flu Relief",
"TopCare Day Time Nite Time Cold and Flu Relief",
"Topcare Day Time Nite Time Cold and Flu Relief",
"TopCare day time severe cold and cough berry infused with menthol and green tea flavors",
"Topcare DayTime",
"Topcare Daytime Nighttime Clear Time",
"Topcare Daytime Nighttime Clear Time",
"Topcare Daytime Nitetime Multi Symptom Relief",
"TopCare Daytime Severe Cold and Cough Berry infused with Menthol and Green Tea flavors",
"Topcare Flu and Severe Cold and Cough",
"Topcare Flu and Severe Cold and Cough",
"Topcare Flu and Severe Cold and Cough Daytime",
"TopCare Health Non Drowsy Daytime Cold and Flu Relief And Nighttime Cold and Flu Relief Day and Night Combo Pack",
"Topcare hemorrhoidal",
"Topcare hemorrhoidal",
"Topcare Hemorrhoidal",
"Topcare hemorrhoidal",
"topcare Hemorrhoidal",
"Topcare Hemorrhoidal",
"Topcare Hemorrhoidal",
"Topcare Hemorrhoidal",
"Topcare Hemorrhoidal",
"Topcare Hemorrhoidal Cooling",
"Topcare mucus relief",
"Topcare Mucus Relief",
"TopCare Mucus Relief and Cold and Flu",
"TopCare Mucus Relief and Cold and Flu",
"Topcare Mucus Relief Cold and Flu",
"Topcare Mucus Relief cold and sinus",
"Topcare mucus relief cold flu and sore throat",
"Topcare Mucus Relief Cold Flu and Sore Throat",
"Topcare Mucus Relief Severe Congestion and Cold",
"TopCare Multi Symptom Severe Cold",
"TopCare Nasal Decongestant PE",
"Topcare Nasal Four",
"TopCare night time severe cold and cough honey lemon infused with chamomile and white tea flavors",
"TopCare Nighttime Cold and Flu Simple Relief",
"TopCare Nighttime Severe Cold and Cough honey lemon infused with chamomile and white tea flavors",
"Topcare Nite Time Cold and Flu",
"Topcare Nite Time Cold and Flu",
"Topcare Nite Time Cold and Flu",
"Topcare Nite Time Cold and Flu",
"Topcare Nite Time Cold and Flu",
"Topcare Nite Time Cold and Flu",
"Topcare Nite Time Day Time Cold and Flu",
"Topcare Nite Time Day Time Cold and Flu Relief",
"Topcare Nose Drops",
"TopCare Pain Relief Cold Nightttime",
"Topcare Severe Sinus Congestion",
"TopCare Sinus and Allergy PE Maximum Strength",
"Topcare Sinus Congestion and Pain",
"Topcare Sinus Congestion and Pain",
"Topcare Sinus Congestion and Pain",
"Topcare Sinus Congestion and Pain",
"Topcare Sinus Relief",
"Topcare Sinus Relief Day Time Night Time",
"Topcare Sinus Relief Day Time Night Time",
"Topcare sinus relief pressure and pain",
"topcare tussin CF",
"Topcare Tussin CF",
"Topcare Tussin CF Max",
"Topcare Tussin CF Max",
"Topcare Tussin CF Max",
"Topco tussin cf max",
"Total Cold",
"Total Cold Hot Lemon Relief",
"Total Cold Night",
"Trexbrom",
"Trexbrom",
"Tri-dex PE",
"Triacting Day Time Cold and Cough Childrens",
"Triacting Day Time Cold and Cough Childrens",
"Triacting Day Time with PE",
"Triacting Day Time with PE",
"Triacting Daytime Cold Cough Childrens",
"Triacting Daytime Cold Cough Childrens",
"Triacting Daytime Cold Cough Childrens",
"Triacting Daytime Cold Cough Childrens",
"Triacting Daytime Cold Cough Childrens",
"Triacting Night Time",
"Triacting Night Time Cold and Cough",
"Triaminic Chest and Nasal Congestion",
"Triaminic Chest and Nasal Congestion",
"TRIAMINIC Childrens Cold and Allergy",
"TRIAMINIC Childrens Night Time Cold and Cough",
"Triaminic Cold and Allergy",
"Triaminic Day - Night Club Pack",
"Triaminic Day - Night Club Pack",
"Triaminic Day Time Cold and Cough",
"Triaminic Day Time Cold and Cough",
"Triaminic Day Time Cold and Cough and Night Time Cold and Cough",
"Triaminic Day Time Cold and Cough and Night Time Cold and Cough",
"Triaminic Daytime Cough & Cold",
"Triaminic Multi-Symptom Fever and Cold",
"TRIAMINIC Night Time Cold and Cough",
"Triaminic Nighttime Cough and Cold",
"Triaminic Thin Strips Cold & Cough",
"Triaminic Thin Strips Nasal Congestion",
"Triaminic Thin Strips Nighttime Cold & Cough",
"Triaminic Toddler Congestion Thin Strips",
"Triaminic Toddler Cough and Cold Thin Strips",
"Trigofen",
"Trigofen DM",
"Triplex DM",
"Triponel",
"Trital DM",
"Trital SR",
"Tukol A",
"Tukol Children Cough and Congestion",
"Tukol Childrens Cold and Flu",
"Tukol Cough And Cold Honey Flavor",
"Tukol Cough and Congestion",
"Tukol Cough and Congestion",
"Tukol Day Time Cold and Flu Relief Softgels",
"Tukol Honey Children Cough and Congestion",
"Tukol Honey Daytime and Nighttime Value Pack",
"Tukol Honey Daytime Cold and Flu",
"Tukol Max Action Cold Sore Throat and Cough",
"Tukol Max Action Cold, Flu and Sore Throat",
"Tukol MAX ACTION Cold, Sore Throat and Cough",
"Tukol MAX ACTION Severe Congestion and Cough",
"Tukol Max Action Severe Congestion and Cough",
"Tukol Max Action Sinus Caplets",
"Tukol Max Action Sinus Liquid",
"Tukol Multi Symptom Cold",
"Tukol X-Pecto Miel Multi Symptom Cold",
"Tusdec DM",
"Tusicof",
"Tusicof",
"Tusnel DM",
"Tusnel Pediatric DM",
"Tusnel Pediatric Drops",
"Tusnel-DM Pediatric",
"Tusscough DHC",
"Tussi Pres",
"Tussi Pres",
"Tussi Pres B",
"Tussi Pres Pediatric",
"Tussin",
"Tussin",
"Tussin CF",
"Tussin CF",
"Tussin CF",
"Tussin CF",
"Tussin CF",
"Tussin CF",
"Tussin CF",
"Tussin CF",
"Tussin CF",
"Tussin CF",
"Tussin CF",
"Tussin CF",
"Tussin CF",
"Tussin CF",
"Tussin CF",
"Tussin CF",
"Tussin CF",
"Tussin CF",
"Tussin CF",
"Tussin CF Adult",
"Tussin CF Adult Cough and Cold",
"Tussin CF Adult Maximum Strength",
"Tussin CF Adult Multi Symptom Cold",
"Tussin CF Adult Non Drowsy",
"Tussin CF Cough and Cold",
"Tussin CF Dextromethorphan HBr, Guaifenesin, Phenylephrine HCL",
"Tussin CF Max",
"Tussin CF Max",
"Tussin CF Max",
"Tussin CF Maximum Strength",
"Tussin CF Maximum Strength",
"Tussin CF Maximum Strength",
"Tussin CF Multi Symptom Cold Adult",
"Tussin CF Multi-Symptom Cold",
"TUSSIN CF NIGHTTIME COUGH and COLD",
"Tussin CF Non Drowsy",
"Tussin CF Non Drowsy",
"Tussin CF Non Drowsy Multi Symptom",
"Tussin CF Non Drowsy Multi Symptom",
"Tussin Maximum Strength",
"Tussin Multi Symptom",
"Tussin Multi Symptom Cold CF",
"Tussin Multi Symptom Cold CF",
"Tussin Multi Symptom Cold CF Adult",
"Tussin Multi Symptom Cold CF Adult",
"Tussin Multi Symptom Cold CF Adult",
"Tussin Multi Symptom Cold CF Adult",
"Tussin Multi Symptom Cold CF Adult",
"Tussin Multi Symptom Cold CF Adult",
"Tussin Multi Symptom Cold CF Adult",
"Tussin Severe",
"Tussin Severe Cough Cold Flu",
"tussin severe multi symptom cough cold plus flu CF MAX",
"Tusslin",
"Tusslin Pediatric",
"Tusslin TR",
"Tussnex FM Cold and Sinus",
"Tussnex FM Cold, Flu and Sore Throat",
"Tussnex FM Severe cough and congestion",
"Twkof Adult",
"Twkof Children",
"Tylenol Allergy",
"Tylenol Allergy Multi-Symptom",
"Tylenol Allergy Multi-Symptom",
"Tylenol Allergy Multi-Symptom Nighttime",
"Tylenol Cold and Flu",
"Tylenol Cold and Flu Daytime",
"Tylenol Cold and Flu Nighttime",
"TYLENOL COLD Cough and Severe Congestion",
"Tylenol Cold Head Congestion Severe",
"Tylenol Cold Head Congestion Severe",
"TYLENOL Cold Max Day",
"Tylenol Cold Max Day",
"Tylenol Cold Max Night",
"Tylenol Cold Multi-Symptom",
"TYLENOL COLD Multi-Symptom",
"Tylenol Cold Multi-symptom",
"TYLENOL Cold Multi-Symptom Daytime",
"Tylenol Cold Multi-symptom Daytime",
"TYLENOL Cold Multi-Symptom Severe",
"Tylenol Cold Nightime Rapid Release",
"TYLENOL Cold plus Flu plus Cough Day",
"Tylenol Cold plus Flu plus Cough Night",
"Tylenol Cold Plus Flu Severe",
"Tylenol Cold Plus Flu Severe",
"TYLENOL Cold Plus Flu Severe",
"Tylenol Cold Plus Flu Severe",
"Tylenol Cold Plus Flu Severe",
"Tylenol Cold Plus Flu Severe",
"Tylenol Cold Plus Flu Severe",
"Tylenol Cold Plus Flu Severe",
"Tylenol Cold Plus Flu Severe",
"Tylenol Cold Plus Flu Severe",
"Tylenol Cold plus Flu Severe and Tylenol Cold Max",
"Tylenol Cold plus Flu Severe and Tylenol Cold Max",
"TYLENOL Cold Plus Flu Severe and TYLENOL COLD MAX CoPack",
"TYLENOL Cold Plus Flu Severe and TYLENOL COLD MAX CoPack",
"Tylenol Cold Plus Flu Severe Day and Tylenol Cold Plus Flu Plus Cough Night 2-pack",
"Tylenol Cold Plus Flu Severe Day and Tylenol Cold Plus Flu Plus Cough Night 2-pack",
"Tylenol Cold Plus Flu Severe Day and Tylenol Cold Plus Flu Plus Cough Night 3-Pack",
"Tylenol Cold Plus Flu Severe Day and Tylenol Cold Plus Flu Plus Cough Night 3-Pack",
"Tylenol Cold Plus Flu Severe Day/night",
"Tylenol Cold Plus Flu Severe Day/night",
"Tylenol Cold Plus Flu Severe Severe",
"Tylenol Cold Plus Head Congestion Severe",
"TYLENOL Cold Plus Mucus Severe",
"Tylenol Cold Rapid Release",
"Tylenol Complete Cold, Cough & Flu Daytime",
"Tylenol Complete Cold, Cough & Flu Nighttime",
"Tylenol Flu Daytime",
"Tylenol Flu Nighttime",
"Tylenol Sinus and Allergy Severe",
"Tylenol Sinus Congestion and Pain",
"TYLENOL SINUS Congestion and Pain",
"Tylenol Sinus Congestion and Pain Daytime",
"Tylenol Sinus Congestion and Pain Severe",
"Tylenol Sinus Congestion and Pain Severe",
"TYLENOL Sinus Congestion And Pain Severe",
"Tylenol Sinus Daytime",
"Tylenol Sinus Nighttime",
"Tylenol Sinus Plus Headache Day",
"Tylenol Sinus Severe",
"Tylenol Sinus Severe",
"Tylenol Sinus Severe",
"Tylenol Sinus Severe",
"Tylenol Sinus Severe",
"Tylenol Sinus Severe",
"Tylenol Sinus Severe",
"Tylenol Sinus Severe",
"Tylo Cold and Flu Day",
"Uline Sinus and Congestion",
"Unishield Cold Relief",
"Unishield Cough and Cold",
"Unishield Sinus Decongestant",
"Up and Up Adult Cough and Cold",
"Up and Up Childrens Cold and Cough",
"Up and Up Childrens Cold and Cough Relief",
"Up and Up Childrens Multi Symptom Cold Pain Relief Plus",
"Up and Up Cold and Flu Relief Multi Symptom Day and Night Combo Pack",
"Up and Up Cold and Head Congestion",
"Up and Up Cold Flu Relief",
"Up and Up Cold Flu Relief",
"Up and Up Cold Flu Relief",
"Up and Up Cold Flu Relief Day Night",
"Up and Up Cold Flu Relief Multi Symptom Day",
"Up and Up Cold Relief",
"Up and Up Cold Relief",
"Up and Up Daytime Cold and Flu",
"Up and Up Daytime Multi Symptom Severe Cold Nighttime Severe Cold and Cough",
"Up and Up Daytime Multi Symptom Severe Cold Nighttime Severe Cold and Cough",
"Up and Up Daytime Nighttime Cold and Flu",
"Up and Up Daytime Nighttime Cold and Flu",
"Up and Up Daytime Severe Cold Nighttime Cold and Flu",
"Up and Up Daytime Severe Cold Nighttime Cold and Flu",
"Up and Up Daytime Vapor Ice Cold and Flu Nighttime Vapor Ice Cold and Flu",
"Up and Up Daytime Vapor Ice Cold and Flu Nighttime Vapor Ice Cold and Flu",
"Up and Up Daytime Vapor Ice Cold and Flu Nighttime Vapor Ice Cold and Flu",
"Up and Up Daytime Vapor Ice Cold and Flu Nighttime Vapor Ice Cold and Flu",
"Up and Up Fast Mucus Relief Severe Cold",
"Up and Up Flu and Severe Cold and Cough Relief",
"Up and Up Flu and Severe Cold and Cough Relief",
"Up and Up Hemorrhoidal",
"Up and Up Hemorrhoidal",
"Up and Up maximum Strength fast mucus relief Severe Congestion and Cough",
"Up and Up Mucus Relief",
"Up and Up Mucus Relief Cold and Sinus",
"Up and Up Mucus Relief Cold Flu and Sore Throat",
"Up and Up mucus relief cold, flu and sore throat",
"Up and Up Mucus Relief Severe Congestion and Cold",
"Up and Up mucus relief severe congestion and cough",
"Up and Up nasal decongestant PE",
"Up and Up Nighttime Daytime Cold and Flu",
"Up and Up Nighttime Flu and Severe Cold and Cough",
"Up and Up Nighttime Severe Cold and Flu",
"Up and Up Nighttime Severe Cold and Flu",
"Up and Up Nighttime Vapor Ice Cold and Flu",
"Up and Up severe cold and flu",
"Up and Up severe cold and flu",
"Up and Up severe cold and flu daytime",
"Up and Up Sinus Congestion and Pain",
"Up and Up Sinus PE",
"Up and Up Tussin Multi Symptom Cold Maximum Strength",
"V-cof",
"V-Hist",
"Vanacof Ape",
"Vanacof DM",
"Vanacof DMX",
"Vanacof Gpe",
"VanaTab DM",
"Vapor Chill Cold and Flu Daytime/nighttime",
"Vapor Chill Cold and Flu Daytime/nighttime",
"Vapor Ice Daytime and Nitetime Cold and Flu",
"Vapor Ice Daytime and Nitetime Cold and Flu",
"Vasosulf Oph Soln",
"Vazculep",
"Vazculep",
"Vazculep",
"Vazculep",
"Vazculep",
"Vazculep",
"Vazobid-PD",
"Vicks 44 D",
"Vicks Childrens Cold Multi Symptom",
"Vicks childrens Cough Congestion",
"Vicks childrens Cough Congestion",
"Vicks Childrens Cough Congestion",
"Vicks Childrens Cough Congestion",
"Vicks childrens Cough Congestion Night",
"Vicks Cough and Cold Severe",
"Vicks Cough and Congestion DM",
"Vicks Cough and Congestion PM",
"Vicks Custom Care Nasal Congestion/cough",
"Vicks DayQuil and Nyquil VapoCOOL Severe COLD and FLU plus CONGESTION",
"Vicks DayQuil and Nyquil VapoCOOL Severe COLD and FLU plus CONGESTION",
"Vicks DayQuil and Vicks NyQuil Cherry Cold and Flu",
"Vicks DayQuil and Vicks NyQuil Cold and Flu",
"Vicks DayQuil and Vicks NyQuil COLD and FLU",
"Vicks DayQuil and Vicks NyQuil Cold and Flu",
"Vicks DayQuil and Vicks NyQuil Cold and Flu Multi-Symptom Relief/Cold and Flu Nighttime Relief",
"Vicks DayQuil and Vicks NyQuil Cold and Flu Multi-Symptom Relief/Cold and Flu Nighttime Relief",
"Vicks DayQuil and Vicks NyQuil Cold and Flu Multi-Symptom Relief/Cold and Flu Nighttime Relief",
"Vicks DayQuil and Vicks NyQuil Cold and Flu Multi-Symptom Relief/Cold and Flu Nighttime Relief",
"Vicks DayQuil and Vicks NyQuil Cold and Flu Multi-Symptom Relief/Cold and Flu Nighttime Relief",
"Vicks DayQuil and Vicks NyQuil Severe Cold and Flu",
"Vicks DayQuil and Vicks NyQuil Severe Cold and Flu",
"Vicks DayQuil and Vicks NyQuil Severe Cold and Flu",
"Vicks DayQuil and Vicks NyQuil Severe Cold and Flu",
"Vicks DayQuil and Vicks NyQuil Severe Cold and Flu",
"Vicks DayQuil and Vicks NyQuil Severe Cold and Flu",
"Vicks DayQuil and Vicks NyQuil Severe Cold and Flu",
"Vicks DayQuil and Vicks NyQuil Severe Cold and Flu",
"Vicks DayQuil and Vicks NyQuil Severe Cold and Flu",
"Vicks DayQuil and Vicks NyQuil Severe Cold and Flu",
"Vicks Dayquil Cold & Flu Multi-symptom Relief Liquicaps",
"Vicks DayQuil Cold and Flu",
"Vicks DayQuil COLD and FLU",
"Vicks DayQuil Cold and Flu",
"Vicks DayQuil Cold and Flu Multi-Symptom Relief",
"Vicks DayQuil Cold and Flu Multi-Symptom Relief",
"Vicks DayQuil Cold and Flu Multi-Symptom Relief",
"Vicks Dayquil Complete Cold & Flu Caplets",
"Vicks Dayquil Complete Cold & Flu Liquicaps",
"Vicks Dayquil Complete Cold & Flu Liquid",
"Vicks DayQuil Cough DM plus Congestion",
"Vicks Dayquil Hot Remedy",
"Vicks DayQuil HOT REMEDY RAPID RELIEF MULTI-SYMPTOM Cold and Flu plus Congestion",
"Vicks DayQuil HOT REMEDY RAPID RELIEF MULTI-SYMPTOM Cold and Flu plus Congestion",
"Vicks DayQuil Kids BERRY COLD and COUGH plus MUCUS",
"Vicks DayQuil Kids Cold Cough plus Mucus",
"Vicks DayQuil Kids Honey and Vicks NyQuil Kids Honey COLD and COUGH plus",
"Vicks DayQuil Kids Honey and Vicks NyQuil Kids Honey COLD and COUGH plus",
"Vicks DayQuil Nature Fusion Cold and Flu",
"Vicks DayQuil NyQuil BERRY Kids COLD and COUGH plus",
"Vicks DayQuil NyQuil HOT REMEDY RAPID RELIEF MULTI-SYMPTOM Cold and Flu plus Congestion",
"Vicks DayQuil NyQuil HOT REMEDY RAPID RELIEF MULTI-SYMPTOM Cold and Flu plus Congestion",
"Vicks DayQuil NyQuil HOT REMEDY RAPID RELIEF MULTI-SYMPTOM Cold and Flu plus Congestion",
"Vicks DayQuil NyQuil HOT REMEDY RAPID RELIEF MULTI-SYMPTOM Cold and Flu plus Congestion",
"Vicks DayQuil NyQuil Severe Cold and Flu combo",
"Vicks DayQuil NyQuil Severe Cold and Flu combo",
"Vicks DayQuil NyQuil Severe Honey Cold and Flu",
"Vicks DayQuil NyQuil Severe Honey Cold and Flu",
"Vicks DayQuil NyQuil ULTRA CONCENTRATED COLD and FLU",
"Vicks DayQuil Severe and Vicks NyQuil Severe Cold and Flu",
"Vicks DayQuil Severe and Vicks NyQuil Severe Cold and Flu",
"Vicks DayQuil Severe and Vicks NyQuil Severe Cold and Flu",
"Vicks DayQuil Severe and Vicks NyQuil Severe Cold and Flu",
"Vicks DayQuil Severe Cold and Flu",
"Vicks DayQuil Severe Cold and Flu",
"Vicks DayQuil Severe Cold and Flu",
"Vicks DayQuil Severe Cold and Flu",
"Vicks DayQuil Severe Honey Cold and Flu",
"VICKS DayQuil SEVERE HONEY FLAVOR COLD and FLU",
"Vicks DayQuil Severe Hot Remedy Cold and Flu plus Congestion",
"Vicks DayQuil Severe Hot Remedy Cold and Flu plus Congestion",
"Vicks DayQuil Sinex Daytime Sinus Relief",
"Vicks DayQuil Sinus",
"Vicks DayQuil ULTRA CONCENTRATED COLD and FLU",
"Vicks DayQuil VapoCOOL SEVERE COLD and FLU plus CONGESTION",
"VIcks Flu Therapy Severe Cold and Flu Day",
"VIcks Flu Therapy Severe Cold and Flu Day",
"VIcks Flu Therapy Severe Cold and Flu Night",
"VIcks Flu Therapy Severe Cold and Flu Night",
"Vicks Formula 44 Cough and Congestion Severe Daytime and Nighttime",
"Vicks Formula 44 Cough and Congestion Severe Daytime and Nighttime",
"Vicks Formula 44 Cough and Head Congestion",
"Vicks Formula 44 VapoCool Cough and Chest Congestion",
"Vicks Formula 44 VapoCool Sever Cough and Congestion",
"Vicks Formula 44 VapoCool Severe Nighttime Cough and Cold",
"Vicks Nyquil Complete Cold & Flu",
"Vicks Nyquil Complete Cold & Flu Caplets",
"Vicks Nyquil Complete Cold & Flu Liquicaps",
"Vicks NyQuil Cough DM plus Congestion",
"Vicks Nyquil Hot Remedy",
"Vicks NyQuil HOT REMEDY RAPID RELIEF MULTI-SYMPTOM Cold and Flu plus Congestion",
"Vicks NyQuil HOT REMEDY RAPID RELIEF MULTI-SYMPTOM Cold and Flu plus Congestion",
"Vicks NyQuil Kids Honey Cold Cough Congestion",
"Vicks NyQuil Kids Honey Cold Cough Congestion",
"Vicks NyQuil Severe Cold and Flu",
"Vicks NyQuil Severe Cold and Flu",
"Vicks NyQuil Severe Cold and Flu",
"Vicks NyQuil Severe Cold and Flu",
"Vicks NyQuil Severe Honey Cold and Flu",
"VICKS NyQuil SEVERE HONEY FLAVOR COLD and FLU",
"Vicks NyQuil Severe Hot Remedy Cold and Flu plus Congestion",
"Vicks NyQuil Severe Hot Remedy Cold and Flu plus Congestion",
"Vicks NyQuil Sinex",
"Vicks NyQuil Sinus",
"Vicks NyQuil VapoCOOL Severe COLD and FLU plus CONGESTION",
"Vicks QlearQuil Daytime Sinus and Congestion",
"Vicks QlearQuil Daytime Sinus and Congestion and Nighttime Sinus and Congestion",
"Vicks QlearQuil Daytime Sinus and Congestion and Nighttime Sinus and Congestion",
"Vicks QlearQuil Nighttime Sinus and Congestion",
"Vicks Severe Cold and Flu",
"Vicks Severe Cold and Flu",
"Vicks Sinex",
"Vicks Sinex",
"Vicks Sinex Decongestant Nasal",
"Vicks Sinex Pressure & Pain",
"Vicks Sinex Severe All in One Sinus",
"Vicks Sinex Severe All in One Sinus Mucus",
"Vicks Sinex Severe Congestion",
"Vicks Sinex Severe Pressure and Pain",
"Vicks Sinex Ultra Fine Mist",
"Vicks Sinex VapoSpray",
"Vicks VapoSyrup",
"Virdec DM Drops",
"Virdec Drops",
"Wal Flu Flu and Sore Throat",
"Wal Flu Severe",
"Wal Flu Severe",
"Wal Flu Severe Cold",
"Wal Flu Severe Cold and Cough",
"Wal Flu Severe Cold and Cough Daytime",
"Wal Flu Severe Cold and Cough Daytime Nighttime",
"Wal Flu Severe Cold and Cough Daytime Nighttime",
"Wal Four",
"Wal Tap Childrens",
"Wal Tussin Adult Cough and Cold",
"Wal Tussin CF Cough and Cold",
"Wal Tussin CF Max",
"Wal Tussin CF Max Multi Symptom Cough Cold and Flu",
"Wal-Dryl Allergy Plus Cold",
"Wal-Dryl Maximum Strength",
"Wal-Dryl PE Allergy and Sinus",
"Wal-Dryl PE ALLERGY PLUS CONGESTION",
"Wal-Dryl-D",
"Wal-Phed HEAD CONGESTION AND MUCUS PE",
"Wal-Phed PE",
"Wal-Phed PE",
"Wal-Phed PE Daytime / Nighttime",
"Wal-Phed PE Daytime / Nighttime",
"Wal-Phed PE Maximum Strength",
"Wal-Phed PE Maximum Strength, Non-Drowsy",
"Wal-Phed PE Multi Symptom",
"Wal-Phed PE Non-Drying Sinus",
"Wal-Phed PE Pressure plus Pain Maximum Strength Non-Drowsy",
"Wal-Phed PE Pressure plus Pain plus Cold Daytime, Nighttime, Multi-Symptom",
"Wal-Phed PE Pressure plus Pain plus Cold Daytime, Nighttime, Multi-Symptom",
"Wal-Phed PE, Multi-Symptom",
"Wal-Phed PE, Multi-Symptom, Daytime, Nighttime",
"Wal-Phed PE, Multi-Symptom, Daytime, Nighttime",
"Wal-Phed PE, Multi-Symptom, Non-Drowsy",
"Walgreen Day Time NightTime Cold and Flu Relief",
"Walgreen Day Time NightTime Cold and Flu Relief",
"Walgreen Day Time Nighttime Cold and Flu Relief Honey Flavor",
"Walgreen Day Time Nighttime Cold and Flu Relief Honey Flavor",
"Walgreen DayTime Cold and Flu Relief",
"Walgreen Daytimel Kids Cold Cough plus Mucus",
"Walgreen Nighttime Cold and Flu",
"Walgreen NightTime Cold and Flu relief",
"Walgreen Severe Multi-Symptom Cough Cold Flu",
"Walgreens",
"Walgreens Daytime Nighttime Wal-Flu Severe Cold and Cough Kit",
"Walgreens Daytime Nighttime Wal-Flu Severe Cold and Cough Kit",
"Walgreens Daytime Non-Drowsy Cold and Flu",
"Walgreens Daytime Non-Drowsy Cold and Flu",
"Walgreens Daytime non-drowsy cold multi-symptom for adults",
"Walgreens Daytime Wal-Flu Severe Cold and Cough Berry infused with Menthol and Green Tea flavors",
"Walgreens Effervescent Cold Relief Plus",
"Walgreens Hemorrhoidal",
"Walgreens Hemorrhoidal Pain Relief",
"Walgreens Maximum Strength Hemorrhoidal",
"Walgreens Maximum Strength Non Drowsy Day and Night Cold and Flu",
"Walgreens Maximum Strength Non Drowsy Day and Night Cold and Flu",
"Walgreens Maximum Strength Non Drowsy Day and Night Cold and Flu",
"Walgreens Maximum Strength Non Drowsy Day and Night Cold and Flu",
"Walgreens Maximum Strength Non-Drowsy Day and Night Sinus and Cold",
"Walgreens Maximum Strength Non-Drowsy Day and Night Sinus and Cold",
"Walgreens Maximum Strength Non-Drowsy Day and Night Sinus and Cold",
"Walgreens Maximum Strength Non-Drowsy Day and Night Sinus and Cold",
"Walgreens Maximum Strength Severe Congestion and Cough",
"Walgreens night time wal-flu severe cold and cough honey lemon flavor infused with chamomile and white tea flavors",
"Walgreens night time wal-flu severe cold and cough honey lemon flavor infused with chamomile and white tea flavors",
"Walgreens Nighttime Kids Honey Cold Cough Congestion",
"Walgreens Severe Cold Multi-Symptom For Adults",
"Walgreens Severe Warming Cold and Flu For Adults",
"Walgreens Sugar Free Nighttime Wal-Flu severe cold and cough Natural honey lemon flavor",
"Walgreens Wal-Flu Cold and Sore Throat Lemon Flavor",
"Walprofen Congestion Relief and Pain",
"Warrior Rectal Care",
"Welby Day Time Cold and Flu",
"Well At Walgreens Multi-Symptom Severe Cold Green Tea and Honey Lemon flavors",
"Well at Walgreens Multi-Symptom Wal-Flu Severe Cold and Nighttime Wal-Flu Severe Cold and Cough Kit",
"Well at Walgreens Multi-Symptom Wal-Flu Severe Cold and Nighttime Wal-Flu Severe Cold and Cough Kit",
"WellBid-D Sustained-Release",
"WellBid-D Sustained-Release",
"Western Family Daytime Severe Cold and Cough Berry infused with Menthol and Green Tea flavors",
"Western Family Hemorrhoidal",
"Western Family Hemorrhoidal",
"Western Family Nighttime Severe Cold and Cough honey lemon infused with chamomile and white tea flavors",
"WesTussin DM",
"WesTussin DM NF",
"Winco Foods Childrens Multi Symptom Cold",
"WinCo Foods Daytime Severe Cold and Cough Berry infused with Menthol and Green Tea flavors",
"WinCo Foods Effervescent Cold Relief",
"Winco Foods Multi-Symptom Severe Cold Green Tea and Honey Lemon flavors",
"WinCo Foods Nighttime Severe Cold and Cough honey lemon infused with chamomile and white tea flavors",
"Winco Hemorrhoidal",
"XL-3 Cold",
"XL-3 Cold Medicine",
"XL-3 Day Time",
"XL-3 Day Time",
"XL-3 Xtra",
"Xl3 Xtra",
"Xpect Cold Relief",
"Xpect Decongestant",
"Xpect Sinus Relief",
"Xpecto soothing relief",
"Xpecto soothing relief",
"Xyralid Hemorrhoidal",
"Xyralid Hemorrhoidal Suppositories",
"Y-Cof DMX",
"Z-dex",
"Zensa Anorectal Gel",
"Zicam",
"Zicam",
"Zincfrin",
"ZoDEN",
"ZoDen DM",
"ZoDen PD",
"Zotex-C"
] |
[
"AK-Dilate",
"AK-Nefrin",
"Alconefrin",
"Mesatone",
"Minims Phenylephrine",
"Neofrin",
"Ocugestrin",
"Phenoptic",
"Phenylephrine Minims",
"Prefrin",
"Rhinall",
"Spersaphrine",
"Visadron"
] |
[
"Phenylephrine Guaifenesin",
"Phenylephrine Hydrochloride, Chlorpheniramine Maleate",
"Dihydrocodeine BPM Phenyleph HCl",
"BPM Mal Phenyleph HCl DM HBr",
"Pyril Mal Phenyl HCl Dex HBr",
"Pyril Mal Phenyl HCl",
"Re Dcp Drops",
"Brom Mal Phenyl HCl Dex HBr",
"Phenylephrine Carbetapentane Potassium Guaiacolsulfonate",
"Trital DM",
"Phenylephrine Complex",
"Deconsal CT",
"Quartuss",
"Tylenol Sinus and Allergy Severe",
"Carbetaplex",
"Deconsal DM",
"Dextromethorphan Tannate, Phenylephrine Tannate, Dexchlorpheniramine Tannate",
"Dextro Phenyl Pyril",
"DiphenMax",
"Little Colds Decongestant Plus Cough",
"Re Drylex",
"Multi-Symptom Daytime Cold",
"Crantex",
"Pyrichlor PE",
"Guiatex PE",
"Mintuss DR",
"Duradryl",
"Quartuss DM",
"Zicam",
"Severe Cold Relief PE",
"Phenylephrine Hydrochloride",
"Our Family night time severe cold and cough honey lemon infused with chamomile and white tea flavors",
"Premier Value day time severe cold and cough berry infused with menthol and green tea flavors",
"Mineral Oil, Petrolatum, Phenylephrine Hydrochloride, Shark Liver Oil",
"Hemorrhoidal Cooling Gel",
"Walgreens night time wal-flu severe cold and cough honey lemon flavor infused with chamomile and white tea flavors",
"Vicks DayQuil Sinus",
"TopCare night time severe cold and cough honey lemon infused with chamomile and white tea flavors",
"Vicks 44 D",
"Our Family day time severe cold and Cough berry infused with menthol and green tea flavors",
"Bronkids",
"Rite Aid night time severe cold and cough honey lemon with chamomile and white tea flavors",
"Brontuss DX",
"Sanatos Day",
"TopCare day time severe cold and cough berry infused with menthol and green tea flavors",
"Nite Time Cold and Cough",
"Hemorrhoidal Cooling Gel",
"Vicks NyQuil Sinus",
"Zicam",
"ACETAMINOPHEN, DEXTROMETHORPHAN HYDROBROMIDE, and PHENYLEPHRINE HYDROCHLORIDE",
"Rite Aid day time severe cold and cough berry infused with menthol and green tea flavors",
"Premier Value night time severe cold and cough honey lemon infused with chamomile and white tea flavors",
"Reeses Onetab Allergy and Sinus",
"DG Health cold multi symptom nite time",
"Reeses Onetab Cold and Flu",
"D Time Sinus",
"Brontuss SF",
"hybrid CF",
"D - Time",
"Allergy and Stuffy Nose",
"Quality Choice night time severe cold and cough honey lemon infused with chamomile and white tea flavors",
"CVS day time cough and severe cold berry infused with menthol and green tea flavors",
"CVS cough and severe cold night time honey lemon infused with chamomile and white tea flavors",
"Glycerin, Phenylephrine Hydrochloride, Pramoxine, White Petrolatum",
"Brotapp PE Liquid",
"Runny Nose and Cough",
"Alka-Seltzer Plus Day Non Drowsy Cold Medicine Citrus",
"Alka-Seltzer Plus Night Cold Medicine",
"DG Health Cold and Allergy",
"Hemorrhoidal Cooling Gel",
"Quality Choice day time severe cold and cough berry infused with menthol and green tea flavors",
"N - Time Sinus",
"Head Congestion Cold Relief",
"Head Congestion Cold Relief",
"Phenylephrine Hydrochloride",
"Phenylephrine Hydrochloride",
"Cocoa Butter, Phenylephrine Hydrochloride, Shark Liver Oil",
"Cvs Hemorrhoidal Cooling",
"Duohist DH",
"Tusscough DHC",
"Trital SR",
"DriHist SR",
"Chlorphenylcaine",
"Cold Medicine XL3",
"Nasohist DM Pediatric",
"Ceron",
"Scot-Tussin Original SF Multi-Symptom",
"Cocoa Butter, Phenylephrine Hydrochloride",
"Entex Lq",
"Sildec PE DM",
"Allergy DN PE",
"Allergy DN PE",
"Shopko Hemorrhoidal",
"Rynatan",
"Reformulated Rynatan Pediatric",
"Rynatan Chewable Pediatric",
"Rynatuss",
"Panadol",
"Promethazine VC With Codeine",
"V-Hist",
"Dallergy PE SYRUP",
"Dallergy PE",
"Dallergy",
"Dallergy",
"Dallergy",
"Promethazine VC With Codeine",
"Refenesen Chest Congestion Relief pe",
"Clophed",
"Corzall PE",
"Dehistine",
"Ceron DM",
"LEADER Chest Congestion Relief PE",
"Daytime Cough And Cold",
"CVS Hemorrhoidal",
"Hemorrhoid Relief",
"Cocoa Butter, Phenylephrine Hydrochloride",
"Allerest PE",
"Reese ONETAB Congestion and cough",
"Promethazine VC",
"Bromhist PDX",
"Corfen DM",
"Nasohist Pediatric",
"Tusdec DM",
"AccuHist PDX",
"AccuHist",
"Endal CD",
"Guaifenesin, Phenylephrine Hydrochloride",
"Bronkids",
"C-Tanna 12D Suspension",
"WellBid-D Sustained-Release",
"WellBid-D Sustained-Release",
"Sonahist DM",
"Reme Hist DM",
"Dcp",
"Sonahist",
"Triplex DM",
"Dihydrocodeine/ BPM/ Phenyleph HCl",
"Coldcough PD",
"Broncotron D",
"Sildec PE",
"Sildec PE DM",
"Tussin CF",
"Day Time Gelcap",
"Endal CD",
"Rexall Maximum Strength Hemorrhoidal",
"Kids-EEZE Cough and Cold",
"Tussin CF",
"Ryna -12 S",
"Ryna -12",
"Dallergy",
"Contac",
"Good Neighbor Pharmacy Cold Multi Symptom",
"Rynesa 12S Suspension",
"A-Tan 12X Suspension",
"Tannate",
"Tannate",
"Chlor-Tan A 12 Suspension",
"Allergy and Cold",
"Medique CCP Caffeine Free",
"Otis Clapp Emagrin Forte",
"Physicians Care Allergy",
"Medique CCP Caffeine Free",
"Otis Clapp Emagrin Forte",
"Tylenol Allergy Multi-Symptom Nighttime",
"Panatuss Pediatric Drops DXP",
"HemAway",
"Leader Hemorrhoidal",
"AlleRx Dose Pack",
"AlleRx Dose Pack PE",
"AlleRx Dose Pack PE",
"Day Time Cold/Flu Relief",
"ATOPALM Hemorrhoidal Pain Relieving",
"Pro-chlo",
"Benadryl Allergy Plus Cold",
"Rescon MX",
"Rescon",
"Rescon Jr",
"Trexbrom",
"Green Guard Cough and Cold Relief",
"Medique Decorel Forte Plus",
"Medi-First Cold Relief",
"Medi-First Plus Cold Relief",
"Moore Medical MooreBrand Severe Cold Relief",
"Dexphen w/ Codeine",
"EndaCof DH",
"Hemorrhoidal",
"NoHist",
"Western Family Hemorrhoidal",
"Crantex",
"Robitussin Night Time Cough, Cold and Flu",
"Bio T Pres-B",
"Norel SR",
"EndaCof Drops",
"Robitussin Night Time Cough, Cold and Flu",
"Sinus Relief Headache Nasal",
"Allergy Relief Multisymptom",
"Hemorrhoidal",
"Cold Relief Severe Pain Cough",
"Formulation R",
"Effervescent Cold Relief",
"Leader Hemorrhoidal",
"Robitussin Cough and Cold CF Max",
"Vicks VapoSyrup",
"ConRx Sinus",
"ConRx Cold",
"ConRx Allergy Sinus Multi-Symptoms",
"Childrens Tylenol Plus Multi-Symptom Cold",
"ATOPALM Hemorrhoidal",
"Tylenol Allergy Multi-Symptom",
"Vicks DayQuil Cold and Flu",
"guaifenesin and phenylephrine hydrochloride Sustained-Release",
"Relief-PE",
"Atrohist Pediatric",
"Physicians Care Cold and Cough",
"Physicians Care Cold and Cough",
"Promethazine VC",
"Brontuss SF-NR",
"LoHist",
"Effervescent Cold Relief",
"Cold Head Congestion",
"Rexall Hemorrhoidal Cooling",
"Riteaid Hemorrhoidal Cooling",
"Panatuss DXP",
"MyHist DM",
"Y-Cof DMX",
"PE Hist DM",
"Family Care Hemorrhoidal",
"Trexbrom",
"Quality Choice Hemorrhoidal",
"Day Time Cold and Flu Relief",
"Mineral Oil, Petrolatum and Phenylephrine HCl",
"Pro-red Ac",
"Safetussin CD",
"Chlo Tuss",
"Pro-red Ac",
"Daytime Cough and Cold",
"Western Family Hemorrhoidal",
"Good Neighbor Pharmacy Mucus Relief PE PE",
"Tabcin 500",
"Bronkids",
"Tylenol Sinus Congestion and Pain Severe",
"Robitussin Cough and Cold CF",
"Tylenol Allergy Multi-Symptom",
"Benadryl-D Allergy and Sinus",
"ConRx Allergy Sinus",
"ConRx Cold",
"Multi Sympton Cold Day Night",
"Multi Sympton Cold Day Night",
"Multi Sympton Cold Day Night",
"Multi Sympton Cold Day Night",
"ConRx Sinus",
"Childrens Tylenol Plus Flu",
"SohMed Sinus",
"TopCare Cold and Sore Throat Lemon Flavor",
"Promethazine HCl, Phenylephrine HCl and Codeine Phosphate",
"Bronco-Flu Plus",
"Tabcin 500",
"Promethazine VC",
"Promethazine VC",
"Daytime Nighttime Cold/flu Relief A P J",
"SohMed Allergy Sinus",
"SohMed Cold Relief",
"Balamine DM Syrup",
"Topcare hemorrhoidal",
"Sinus Relief Daytime Nighttime",
"Sinus Relief Daytime Nighttime",
"Daytime Multi-Symptom Cold/Flu Relief",
"Refresh Redness Relief",
"R-Tanna",
"Scot-Tussin Original SF Multi-Symptom",
"Sildec PE DM",
"Tl-hist DM",
"Nite Time Cold and Cough",
"Childrens Cold, Cough and Sore Throat",
"Tl-hist CD",
"ZoDEN",
"Budpak Hemorrhoid Anesthetic",
"Day Time Gelcap",
"Broncotron PED",
"Broncotron PED",
"Childrens Multi-Symptom Cold",
"Childrens Night Time COUGH and COLD RELIEF",
"Mucus Relief Severe Congestion and Cough Maximum Strength",
"Promethazine VC With Codeine",
"Mayinglong Bezornil Hemorrhoidal",
"Night Time Cough and Cold Relief",
"Vanacof Ape",
"Vanacof Gpe",
"Adult Cold, Flu and Sore Throat",
"Childrens Tylenol Plus Cold and Allergy",
"Tylenol Cold Head Congestion Severe",
"Childrens Tylenol Plus Multi-Symptom Cold",
"Multi Symptom Cold Allergy Tabs",
"Acetaminophen Sinus Congestion and Pain A P J Coated",
"Shopko Hemorrhoidal",
"CVS Pharmacy Daytime Nighttime Severe Cold and Cough Kit",
"CVS Pharmacy Daytime Nighttime Severe Cold and Cough Kit",
"Skopko Chest Congestion Relief PE PE",
"Topcare hemorrhoidal",
"Medique Onset Forte",
"Z-dex",
"Childrens Mucinex Congestion and Cough",
"Endacon",
"Severe Congestion and Cough MAX Maxium Strength",
"Daytime Sinus Relief",
"Adult Severe Congestion and Cough",
"Tylenol Cold Head Congestion Severe",
"Ed A-hist",
"Entex LQ",
"Tylenol Cold Multi-Symptom",
"CVS Pharmacy Daytime Severe Cough and Cold Berry infused with Menthol and Green Tea flavors",
"CVS Pharmacy Cold and Sore Throat Lemon Flavor",
"Tylenol Sinus Congestion and Pain",
"Sudafed PE Non-Drowsy Sinus Headache MAXIMUM STRENGTH",
"TYLENOL COLD Cough and Severe Congestion",
"Day Time Cold/Flu Relief",
"Baczol Cold Medicine",
"Baczol Expectorant",
"Day Time Night Time Sinus Relief",
"Day Time Night Time Sinus Relief",
"CVS Pharmacy Nighttime Severe Cough and Cold honey lemon infused with chamomile and white tea flavors",
"Apj Hemorrhoidal",
"Trigofen",
"ZoDen DM",
"ZoDen PD",
"Trigofen DM",
"Tri-dex PE",
"Tl-hist DM",
"Mucinex Fast-Max Day Time Severe Cold and Mucinex Fast-Max Night Time Cold and Flu Maximum Strength",
"Mucinex Fast-Max Day Time Severe Cold and Mucinex Fast-Max Night Time Cold and Flu Maximum Strength",
"Broncomar",
"DayTime Cold and Flu",
"Alka-Seltzer Plus Severe Cough and Cold Day and Night",
"Alka-Seltzer Plus Severe Cough and Cold Day and Night",
"Hemorrhoidal",
"Poly Hist Forte",
"Balahist DM Syrup",
"Daytime Nighttime Cold/Flu",
"Hemorrhoidal",
"Childrens Delsym Cough Plus Cold Day Time",
"Sinutab Sinus MAXIMUM STRENGTH",
"HealthMart Mucus Relief FM",
"HealthMart Mucus Relief FM",
"HealthMart Mucus Relief FM",
"Mucinex Sinus-Max Pressure and Pain",
"Virdec Drops",
"Virdec DM Drops",
"Vicks NyQuil Sinex",
"Vicks DayQuil Sinex Daytime Sinus Relief",
"Poly-Tussin AC",
"Tylenol Sinus Congestion and Pain Severe",
"Vicks DayQuil Nature Fusion Cold and Flu",
"Liquibid PD-R",
"Liquibid D-R",
"Multi-Symptom Relief Cold and Flu Multi-Symptom Relief",
"Robitussin Peak Cold Daytime Cold Plus Flu",
"Tussin CF",
"Topcare Hemorrhoidal",
"Despec DM",
"Makesense",
"Refenesen Chest Congestion Relief PE",
"Delsym Cough Plus Cold Day Time and Delsym Cough Plus Cold Night Time",
"Delsym Cough Plus Cold Day Time and Delsym Cough Plus Cold Night Time",
"Hemorrodil",
"Mucinex Sinus-Max Day Night Maximum Strength",
"Mucinex Sinus-Max Day Night Maximum Strength",
"Cold and Chest Congestion Relief",
"Tussin CF",
"Altidome DMX",
"Biophex TR",
"Biogtuss TR",
"TopCare Nighttime Severe Cold and Cough honey lemon infused with chamomile and white tea flavors",
"Sinus and Allergy PE",
"Flu and Sore Throat Relief",
"Night Time Severe Cold and Cough Relief",
"Nikzon Hemorrhoidal",
"Hemorrhoidal",
"Quality Choice Mucus Relief PE PE",
"Daytime Nighttime Cold/flu",
"Cold Multi-Symptom Day-time",
"Mucus Relief D Immediate Release",
"Mucinex Fast-Max Night Time Cold and Flu",
"Acetaminophen Phenylephrine HCl",
"Cough Multi Symptom",
"Pain Reliever Fever Reducer",
"CounterAct Night",
"CounterAct Day",
"Select Brand Mucus Relief PE",
"ConRX DayTime",
"Topcare Cold and Sore Throat Lemon Flavor",
"TopCare Daytime Severe Cold and Cough Berry infused with Menthol and Green Tea flavors",
"ConRX Pain Reliever Sinus Headache",
"LoHist PEB DM",
"LoHist PEB",
"Cold and Allergy Relief",
"Tylenol Sinus Congestion and Pain Daytime",
"Pyril D",
"Nasohist Pediatric",
"Aldex CT",
"Nasohist DM Pediatric",
"Family Care Multi Symptom Cold",
"Severe Cold PE Multi-Symptom",
"Allergy and Sinus Headache",
"Allergy and Sinus Headache",
"Multi-Symptom Cold Warming Effect Daytime",
"Mucinex Fast-Max Day Time Severe Cold and Mucinex Fast-Max Night Time Cold and Flu Maximum Strength",
"Mucinex Fast-Max Day Time Severe Cold and Mucinex Fast-Max Night Time Cold and Flu Maximum Strength",
"Altilan CL",
"Altidesp",
"Up and Up Nighttime Flu and Severe Cold and Cough",
"Cardec",
"Acetaminophen,Dextromethorphan,Phenylephrine",
"Cold Multi-Symptom Daytime Non-Drowsy",
"Wal-Phed PE Non-Drying Sinus",
"Lucky SuperSoft",
"Walgreens Daytime Nighttime Wal-Flu Severe Cold and Cough Kit",
"Walgreens Daytime Nighttime Wal-Flu Severe Cold and Cough Kit",
"Walgreens night time wal-flu severe cold and cough honey lemon flavor infused with chamomile and white tea flavors",
"Well At Walgreens Multi-Symptom Severe Cold Green Tea and Honey Lemon flavors",
"Well at Walgreens Multi-Symptom Wal-Flu Severe Cold and Nighttime Wal-Flu Severe Cold and Cough Kit",
"Well at Walgreens Multi-Symptom Wal-Flu Severe Cold and Nighttime Wal-Flu Severe Cold and Cough Kit",
"Xl3 Xtra",
"Sinu-Phen Plus",
"Premier Value Hemorrhoidal",
"Preparation H",
"Mucinex Sinus-Max Severe Congestion Relief Maximum Strength",
"Allergy and Cold Relief",
"Daytime Multi-Symptom Cold Relief",
"Severe Cold Relief",
"Multi-Symptom Daytime Cold",
"Multi-Symptom Nighttime Cold",
"Suphedrine PE",
"Cardec DM",
"Brompheniramine Phenylephrine DM",
"Allergy Relief",
"G-bronco-D",
"Dr. Cocoa Daytime Cough and Cold",
"Aldex D",
"Mucus Relief Plus",
"Allergy Plus Sinus Relief",
"Sinus Relief Daytime",
"Multi-Symptom Daytime Cold",
"Flu Relief Therapy Daytime Severe Cold",
"XL-3 Cold Medicine",
"Sinus and Allergy PE Maximum Strength",
"Nighttime Cold and Flu Relief Plus",
"Rapid Release Multi-Symptom Allergy Relief",
"Multi-Symptom Cold Relief",
"Day-Time Night-Time",
"Daytime cold and flu relief",
"Daytime Cold and Flu Relief",
"TYLENOL SINUS Congestion and Pain",
"V-cof",
"Allergy Multi-Symptom",
"Daytime Cold and Flu Relief Plus",
"Severe Multi-Symptom Cold",
"Sinus Congestion and Pain Daytime",
"Sinus Congestion and Pain Severe",
"Auro Tap Childrens Cold and Allergy",
"Night Time Sinus and Congestion",
"Daytime Sinus and Congestion",
"Alticotron",
"Cold and Flu Relief Daytime Non Drowsy",
"Allergy Multi-Symptom",
"Rite Aid Daytime Severe Cold and Cough Relief",
"Childrens Mucinex Multi-Symptom Cold",
"Rite Aid Nighttime Severe Cold and Cough Relief",
"Klernaz",
"ShopRite Nighttime Flu Plus Severe Cold and Cough",
"TYLENOL COLD Multi-Symptom",
"ShopRite DayTime Flu Plus Severe Cold And Cough",
"TYLENOL Sinus Congestion And Pain Severe",
"SMITH BROS NON-DROWSY DAY TIME COLD and FLU",
"Childrens Cold and Allergy",
"Dr. Cocoa Nighttime Cough and Cold",
"Cold and Cough PE",
"Severe Allergy Plus Sinus Headache Maximum Strength",
"Cold and Flu Multi-Symptom Daytime Nighttime",
"Daytime Cold and Flu Relief",
"Cold and Flu Daytime",
"Non-Drowsy Daytime Multi-Symptom Cold and Flu",
"TYLENOL Cold Multi-Symptom Daytime",
"WinCo Foods Nighttime Severe Cold and Cough honey lemon infused with chamomile and white tea flavors",
"WinCo Foods Daytime Severe Cold and Cough Berry infused with Menthol and Green Tea flavors",
"Cold and Flu Daytime Nighttime",
"Daytime Multi-Symptom Non-Drowsy Cold and Flu",
"SMITH BROS NON-DROWSY MULTI-SYMPTOM COLD and FLU",
"SMITH BROS NIGHT TIME COUGH and CONGESTION",
"Childrens Mucinex Stuffy Nose and Cold",
"Next Day Time Non drowsy Cold and Flue",
"Premier Value Chest and Sinus Congestion relief",
"Walgreens Daytime Wal-Flu Severe Cold and Cough Berry infused with Menthol and Green Tea flavors",
"Walgreens Sugar Free Nighttime Wal-Flu severe cold and cough Natural honey lemon flavor",
"Premier Value Hemorrhoidal",
"Doctor Manzanilla Cough Suppressant and Nasal Decongestant",
"Sinus Headache PE Maximum Strength",
"Multi-Symptom Daytime and Nighttime Cold and Flu Relief Plus",
"Multi-Symptom Daytime and Nighttime Cold and Flu Relief Plus",
"Day Time and Night Time Sinus and Congestion",
"Day Time and Night Time Sinus and Congestion",
"Mucinex Fast-Max Cold and Sinus",
"Wal-Dryl Allergy Plus Cold",
"Nasotuss",
"Corfen DM",
"Pyril DM",
"Acetaminophen Phenylephrine HCl",
"Delsym Childrens Night Time Cough and Cold",
"Delsym Night Time Multi Symptom",
"Nighttime Multi-Symptom Cold",
"Non Drowsy Cold and Cough PE",
"PE multi-stymptom cold and cough relief",
"Wal-Phed PE",
"Defensol-ito",
"Family Care Cold and Flu Multi Symptom",
"Tylenol Cold Multi-symptom Daytime",
"Day Time Cold non drowsy cold and Flu Relief",
"DayTime Multi-Symptom Flu Cold Medicine",
"Best Choice Nighttime Severe Cold and Cough Honey Lemon infused with Chamomile and White Tea Flavors",
"Western Family Daytime Severe Cold and Cough Berry infused with Menthol and Green Tea flavors",
"Western Family Nighttime Severe Cold and Cough honey lemon infused with chamomile and white tea flavors",
"Goyescas 7 Syrups Alcohol and Sugar Free Cough and Cold",
"Goyescas Broncovac 3 Cough and Cold",
"Goyescas 7 Syrups with Bee Honey Cough and Cold",
"Goyescas Broncovac 1 Cough and Cold",
"Goyescas 7 Syrups Original Cough and Cold",
"Goyescas Broncovac 2 Cough and Cold",
"Premier Value Hemorrhoidal",
"Premier Value Hemorrhoidal",
"Hemorrhoidal Rectal",
"Daytime and Nighttime Cold and Flu Relief Plus",
"Daytime and Nighttime Cold and Flu Relief Plus",
"Flu Relief Therapy Day Time",
"Kroger NiteTime Flu plus Severe Cold and Cough",
"Day and Night Cold PE",
"Day and Night Cold PE",
"Kroger DayTime Flu plus Severe Cold and Cough",
"HEB DayTime Flu And Severe Cold And Cough",
"Despec NR",
"Best Choice Daytime Severe Cold and Cough Berry infused with Menthol and Green Tea flavors",
"Glenmax PEB DM FORTE",
"Glenmax PEB",
"Glenmax PEB DM",
"Glen PE",
"Severe Cold and Flu Relief",
"Cold and Allergy Relief",
"Equaline Hemorrhoidal",
"7 Select Hemorrhoidal Original Strength",
"Sinus and Allergy PE",
"Mucinex Fast-Max Night Time Cold and Flu",
"Mucinex Fast-Max Severe Cold",
"Safeway Daytime Cold and Flu Relief",
"Multi-Symptom Nighttime Sinus Relief",
"Broncochem Expectorant II",
"Non-drowsy Daytime Sinus Relief",
"Day Time Cold and Flu cold and flu multi symptom relief",
"Multi-Symptom Cold Relief",
"Multi-Symptom Cold Relief",
"Hemorrhoid Anesthetic",
"Hemorrhoidal",
"Bpm-DM-phen",
"Hemorrhoidal Anesthetic",
"Robitussin Night Time Cough and Cold",
"Severe Cold Multi-Symptom",
"Cold Head Congestion Severe",
"Aspirin Free Cold Head Congestion Day Time",
"Cold and Flu Severe",
"Dometuss-G",
"Cold Head Congestion Non-Drowsy",
"Daytime Cold and Pain Relief",
"Cold and Flu Relief Severe",
"Head Congestion and Cold Relief Daytime",
"Childrens Mucinex Multi-Symptom Cold",
"Donatuss DC",
"Cold-EEZE Daytime Cold and Flu",
"Rexall Maximum Strength Hemorrhoidal",
"Hemorrhoidal",
"Day Time Cold Multi-Symptom",
"Cold-EEZE Nighttime Cold and Flu",
"Cold-EEZE Childrens Nighttime Cold and Cough Relief",
"Sinus Pressure and Pain Maximum Strength",
"Premier Value Multi-Symptom Severe Cold Green Tea and Honey Lemon flavors",
"Walgreens Wal-Flu Cold and Sore Throat Lemon Flavor",
"Head Congestion Cold Relief Severe Non-Drowsy",
"SINUS PAIN AND CONGESTION Nighttime",
"Maximum Strength Nighttime Cold/Flu Relief",
"Mucinex Fast-Max Severe Congestion and Cough Liquid Pouches",
"Allerfed",
"Childrens Benadryl-D ALLERGY and SINUS",
"Triacting Daytime Cold Cough Childrens",
"R-Tanna Pediatric Suspension",
"Panadol Cold and Flu NonDrowsy",
"Topcare Cold",
"Topcare Cold",
"Allergy Multi-Symptom",
"Maximum Strength Mucus Relief Cold Flu and Sore Throat",
"Premier Value night time severe cold and cough honey lemon infused with chamomile and white tea flavors",
"Wal-Dryl-D",
"Wal-Phed PE, Multi-Symptom, Non-Drowsy",
"Sinus Congestion and Pain Daytime/Nighttime",
"Sinus Congestion and Pain Daytime/Nighttime",
"Sinus Congestion PE",
"Winco Foods Multi-Symptom Severe Cold Green Tea and Honey Lemon flavors",
"Vicks QlearQuil Daytime Sinus and Congestion and Nighttime Sinus and Congestion",
"Vicks QlearQuil Daytime Sinus and Congestion and Nighttime Sinus and Congestion",
"Mucinex Sinus-Max Pressure and Pain",
"Vicks QlearQuil Daytime Sinus and Congestion",
"Vicks QlearQuil Nighttime Sinus and Congestion",
"TRIAMINIC Childrens Night Time Cold and Cough",
"TRIAMINIC Childrens Cold and Allergy",
"Mucus Relief Maximum Strength",
"Mucinex Fast-Max Cold, Flu and Sore Throat",
"Mucinex Fast-Max Day Time Severe Cold and Mucinex Fast-Max Night Time Cold and Flu Maximum Strength",
"Mucinex Fast-Max Day Time Severe Cold and Mucinex Fast-Max Night Time Cold and Flu Maximum Strength",
"Mucinex Fast-Max Severe Congestion and Cold",
"Defensol D (Multi Symptom Effervescent Tablets)",
"Careone night time severe cold and cough honey lemon infused with chamomile and white tea flavors",
"CareOne Daytime Severe Cold and Cough Berry infused with Menthol and Green Tea flavors",
"Quality Choice Cold and Sore Throat Lemon Flavor",
"Quality Choice Daytime Severe Cold and Cough Berry infused with Menthol and Green Tea flavors",
"Quality Choice Nighttime Severe Cold and Cough Honey Lemon infused with Chamomile and White Tea Flavors",
"Codituss DM",
"Non-Drying Sinus PE",
"Multi-Symptom Cold Relief",
"Multi-Symptom Cold Relief",
"Sinus and Allergy PE",
"Topcare Daytime Nighttime Clear Time",
"Topcare Daytime Nighttime Clear Time",
"Ru-hist-D",
"Ru-hist-D",
"Ru-hist Plus",
"Nu-copd",
"Mucinex Sinus-Max Severe Congestion Relief Clear and Cool",
"Mucinex Fast-Max Congestion and Headache Clear and Cool",
"Mucinex Fast-Max Night Time Cold and Flu Clear and Cool",
"Kroger Cough Cold and Flu",
"Topcare Clear Time",
"Topcare Severe Sinus Congestion",
"Topcare Cold and Flu",
"Topcare Clear Time",
"Centussin Dhc",
"Lusair",
"Airacof",
"Broncomar EXPECTORANT",
"R-Tanna",
"Bio-G-Tuss Pediatric Drops",
"Theraflu ExpressMax Daytime Nighttime Value Pack",
"Theraflu ExpressMax Daytime Nighttime Value Pack",
"Cold Relief Multi-symptom, Daytime",
"Daytime Cold and Flu",
"Multi-Symptom Cold Relief Daytime, Nighttime",
"Multi-Symptom Cold Relief Daytime, Nighttime",
"Meijer Nighttime Severe Cold and Cough Honey Lemon infused with Chamomile and White Tea Flavors",
"Meijer Daytime Severe Cold and Cough Berry infused with Menthol and Green Tea flavors",
"Meijer Multi-Symptom Severe Cold Green Tea and Honey Lemon flavors",
"Smart sense Nighttime Severe Cold and Cough Honey Lemon infused with Chamomile and White Tea Flavors",
"Family Wellness",
"Cold Tabs II",
"J-max",
"DryMax AF",
"Pluratuss",
"Kroger Sinus Pain and Pressure",
"DayTime Cold and Flu",
"DayTime Cold and Flu",
"Duo-Medihaler",
"Calmadol Plus",
"Childrens Multi Symptom Cold",
"Childrens Mucinex Multi-Symptom Cold and Fever",
"Childrens Mucinex Stuffy Nose and Cold",
"Childrens Mucinex Night Time Multi-Symptom Cold",
"Childrens Mucinex Cold, Cough and Sore Throat",
"Assured Maximum Strength Mucus Relief",
"Broncochem Cold and Flu Caplets",
"R-Tanna",
"CVS Chest Congestion Relief PE",
"Severe Congestion and Cough Relief",
"Coltalin-ND",
"Coltalin",
"Coltalin-DM",
"Kroger NiteTime Cold and Flu",
"Theraflu Nighttime Multi-Symptom Severe Cold Powder",
"SINUS PRESSURE Maximum Strength",
"Major Prep Hemorrhoidal",
"Promethazine VC",
"Severe Cold Relief PE",
"Scot-Tussin Original Multi-Symptom Cold and Allergy Relief",
"Poly Hist Dhc",
"Poly-tussin DM",
"Premier Value Multi-Symptom Severe Cold Green Tea and Honey Lemon flavors",
"Sinus Pain and Congestion Daytime",
"Childrens Plus Multi-Symptom Cold Grape with PE",
"Tussin CF",
"Allergy and Sinus Headache Relief Complete",
"Daytime Nighttime Cold/flu",
"Flu Relief Therapy Day Time",
"Poly Hist Pd",
"Poly-tussin EX",
"Freds Hemorrhoidal",
"Leader Flu and Severe Cold and Cough",
"Leader Cold Head Congestion",
"SanaTos COLD Multi-Symptom",
"SanaTos COLD Multi-Symptom",
"Equate Hemorrhodial Suppositories",
"Dr. Cocoa Mucus Relief",
"Family Care Cold and Flu Multi Symptom Relief SGC Daytime",
"Wal Tap Childrens",
"Maximum Strength Mucus Relief Cold,Flu and Sore Throat",
"Mucus Relief Cold and Sinus Maximum Strength",
"Maximum Strength Mucus Relief Severe Congestion and Cough",
"Good Sense Hemorrhoidal",
"Good Sense Sinus and Allergy PE",
"Allergy Multi-Symptom",
"Good Sense Cold and Allergy",
"Good Sense Mucus Relief Severe Congestion and Cold",
"Good Sense Flu and Severe Cold and Cough",
"Good Sense hemorrhoidal",
"ShopRite Cold Multi Symptom",
"Multi-Symptom Cold and Cough Daytime Nighttime",
"Multi-Symptom Cold and Cough Daytime Nighttime",
"Leader Childrens Mucus Relief",
"Severe Allergy Plus Sinus Headache Maximum Strength",
"Day Time with PE",
"Nighttime Cold Head Congestion",
"Flu Relief Therapy Day Time",
"Flu Relief Therapy Night Time",
"Hemorrhoidal",
"CVS Health Chest Congestion Relief PE",
"Hemorrhoidal",
"ShopRite Adult Tussin",
"Cold Head Congestion Severe",
"Hemorrhoidal",
"Cold and Allergy PE",
"ShopRite Hemorrhoidal",
"ShopRite Severe Cold",
"Hemorrhoidal",
"Multi Symptom Cold Childrens",
"Daytime",
"Hemorrhoidal",
"Tussin CF Max",
"Smart Sense Hemorrhoidal",
"Smart Sense Hemorrhoidal",
"Flu and Sore Throat",
"Theraflu Sugar Free Nightime Severe Cold and Cough",
"Theraflu Warming Relief Daytime Multi-Symptom Cold Caplets",
"Theraflu Sinus and Cold",
"Theraflu Warming Relief Nighttime Multi-Symptom Cold Caplets",
"Theraflu Cold and Sore Throat",
"Good Neighbor pharmacy severe night time",
"DayTime Cold and Flu Relief",
"Little Colds Multi Symptom Cold plus Fever",
"Pain Relief Plus",
"Good Neighbor Pharmacy Cold",
"Cold and Flu Severe",
"Allergy Relief",
"Equaline nighttime cold multi symptom",
"Sinus Congestion and Pain",
"Sinus Congestion and Pain",
"Cold relief",
"Good Neighbor Pharmacy Flu and Sore throat",
"Theraflu ExpressMax Severe Cold and Flu Caplets",
"Sinus Congestion and Pain Severe",
"Zotex-C",
"RelCof DM",
"Up and Up mucus relief severe congestion and cough",
"Sinus Congestion and Pain Daytime",
"Theraflu Warming Relief Flu and Sore Throat",
"Theraflu Warming Relief Cold and Chest Congestion",
"Theraflu Warming Relief Daytime Severe Cold And Cough",
"Theraflu Warming Relief Nighttime Severe Cold And Cough",
"Childrens Plus Flu with PE",
"DiBromm with PE",
"Childrens Plus Cold Grape",
"Childrens Plus Cold Grape",
"Day Time with PE",
"Tussin CF",
"Day Time with PE",
"Circle K Daytime Cold and Flu",
"Alka-Seltzer Plus Severe Sinus and Cold",
"Advil Congestion Relief",
"Childrens Dimetapp Cold and Allergy",
"Childrens Dimetapp Multisymptom Cold and Flu",
"Coldtac Ultra",
"COLDTAC Plus",
"Flu Relief Therapy",
"CareOne Childrens Cold and Allergy",
"Flu Relief Therapy",
"PhysiciansCare Cold and Cough Non-Drowsy",
"MucaphEd",
"Cvs Health Hemorrhoidal Cooling Hemorrhoidal",
"Cold Medicine",
"Non-Drowsy DayTime Cold and Flu Multi-Symptom Relief",
"NightTime Sinus Relief",
"DayTime Sinus Relief",
"Up and Up Cold and Head Congestion",
"HemorrhoidalOintment",
"Up and Up Cold Relief",
"Up and Up Cold Relief",
"Up and Up Adult Cough and Cold",
"Triaminic Multi-Symptom Fever and Cold",
"Cold Relief Daytime",
"Xpecto soothing relief",
"Acetaminophen Dextromethorphan Hydrobromide Doxylamine Succinate Phenylephrine Hydrochloride",
"Acetaminophen Dextromethorphan Hydrobromide Doxylamine Succinate Phenylephrine hydrochloride",
"HemAway",
"Theraflu ExpressMax Severe Cold and Flu Syrup",
"Acetaminophen Dextromethorphan Hydrobromide Phenylephrine Hydrochloride",
"Acetaminophen Dextromethorphan Hydrobromide Phenylephrine Hydrochloride",
"Childrens SUDAFED PE Cold plus Cough",
"Pain Relief Cold Multi Symptom",
"Equaline Daytime Cold Multi Symptom",
"Care One Cold Multi Symptom",
"Carbatuss",
"Topcare Cold Multi Symptom",
"Theraflu Nighttime Severe Cold and Cough",
"DiBromm DM",
"Theraflu Daytime Severe Cold and Cough",
"Biocotron PED",
"Flu and Severe Cold and Cough Nighttime",
"Good Neighbor Pharmacy Cleartime",
"Flu and Severe Cold and Cough",
"Hemorrhoidal",
"Equaline hemorrhoial",
"Equaline Night Time Cold and Cough Childrens",
"Hemorrhoidal",
"Good Neighbor Pharmacy Flu and Severe Cold Daytime",
"Hemorrhoidal",
"Good Neighbor Pharmacy Allergy Multi Symptom",
"Good Neighbor Pharmacy Sinus Congestion and Pain",
"Equaline Daytime Nighttime Cold and Flu Relief",
"Good Neighbor Pharmacy Mucus Relief Severe Congestion and Cold",
"Good Neighbor Pharmacy Sinus",
"Good Neighbor Pharmacy Sinus",
"Good Neighbor Pharmacy Sinus and Allergy PE",
"Pyrilamine Maleate and Phenylephrine Hydrochloride",
"Good Neighbor Pharmacy Flu and Severe Cold and Cough",
"Good Neighbor Pharmacy Day Time",
"Equaline Hemorrhoidal",
"Good Neighbor Pharmacy Flu and Severe Cold and Cough Nighttime",
"Severe Allergy And Sinus Headache",
"Broncochem Allergy Control",
"Triacting Night Time",
"Mucinex Fast-Max Severe Cold",
"Tussin CF",
"Promethazine Vc With Codeine",
"Equate Sinus Night Time",
"Equate Night Time Cold and Cough Childrens",
"Equate Hemorrhoidal",
"Equate hemorrhoidal",
"Equate Sinus Day Time",
"Allergy Plus Sinus Headache",
"Equate Hemorrhoidal",
"Broncochem Kids Cold and Flu",
"Promethazine Hydrochloride and Phenylephrine Hydrochloride",
"Healthy Accents hemorrhoidal",
"Hemorrhoidal",
"Mucus Relief Cold Flu and Sore Throat",
"Hemorrhoidal Relief",
"Preferred Plus Mucus Relief",
"Flu Relief Therapy Night Time",
"Mucus Relief Cold, Flu and Sore Throat Maximum Strength",
"Extra Fast Coltalin",
"Day Time with PE",
"Tussin CF Multi-Symptom Cold",
"Childrens Plus Multi-Symptom Grape with PE",
"Mucinex Sinus-Max Severe Congestion Relief",
"Mucinex Fast-Max Night Time Cold and Flu",
"Sudafed PE Pressure plus Pain plus Cough",
"WinCo Foods Effervescent Cold Relief",
"Relhist DMX",
"Fulton Street Market Cold",
"Up and Up Cold Flu Relief",
"Up and Up Tussin Multi Symptom Cold Maximum Strength",
"Preferred Plus Severe Cold Cough and Flu",
"Up and Up Childrens Cold and Cough",
"Up and Up Flu and Severe Cold and Cough Relief",
"Preferred Plus Severe Cold Day Time Cold and Flu Night Time",
"Preferred Plus Severe Cold Day Time Cold and Flu Night Time",
"Fulton Street Market Nighttime Flu and Severe Cold and Cough",
"Preferred Plus Sinus Relief",
"Preferred Plus Sinus Relief",
"Preferred Plus Severe Cold Cough and Flu",
"Preferred Plus Severe Sinus Congestion",
"Cold and Flu Relief Daytime Nighttime",
"Preferred Plus Congestion Relief",
"Preferred Plus Sinus Relief Day Tiime Night Time",
"Preferred Plus Sinus Relief Day Tiime Night Time",
"Up and Up Mucus Relief Cold Flu and Sore Throat",
"Up and Up Mucus Relief Severe Congestion and Cold",
"Preferred Plus Mucus Relief Cold and Sinus",
"Formu Care Flu and Severe Cold and Cough Night Time",
"Up and Up Mucus Relief Cold and Sinus",
"Up and Up Cold Flu Relief",
"Preferred Plus Day Time Cold and Flu",
"Up and Up Flu and Severe Cold and Cough Relief",
"Up and Up Childrens Cold and Cough Relief",
"PhysiciansCare Cold and Cough Non-Drowsy",
"DG Health Fast Acting Mucus Relief Severe Congestion and Cold",
"Harris Teeter Day Time",
"Members Mark Allergy",
"DG Health Cold Head Congestion",
"Dg Health Hemorrhoidal",
"DG Health Hemorrhoidal",
"DG Health Triacting Childrens",
"DG health allergy multi symptom",
"DiBromm with PE",
"Rexall Hemorrhoidal Cooling",
"CareOne Childrens Mucus Relief",
"Humana Pharmacy Tussin Multi Symptom Cold",
"Ed A-hist",
"Hemorrhoidal",
"Childrens Tukol Multi-Symptom Cold and Flu",
"Next Night Severe Cold, Flu and Sore Throat",
"Tukol MAX ACTION Cold, Sore Throat and Cough",
"Tukol MAX ACTION Severe Congestion and Cough",
"Multi Symptom Cold Plus Childrens Pain Relief",
"Mucus Relief Severe Congestion and Cold",
"Plus Multi Symptom Cold Childrens Pain Relief",
"Daytime Nighttime",
"Hemorrhoidal",
"Leader Hemorrhoidal",
"Day Time with PE",
"Tussin CF Dextromethorphan HBr, Guaifenesin, Phenylephrine HCL",
"Cold and Flu Relief Daytime Multi Symptom",
"Sinus Relief Non Drowsy",
"Flu and Severe Cold and Cough Daytime",
"Sunmark Hemorrhoidal",
"Cold Relief",
"Cold Relief",
"Sunmark Sinus and Allergy PE Maximum Strength",
"Hemorrhoidal",
"Dayrelief PE",
"Nighttime Cold",
"Mucus Relief Severe Congestion and Cold",
"Congestion Relief",
"Tussin CF Adult Non Drowsy",
"Cold and Flu Nighttime",
"DayRelief NON DROWSY MULTI SYMPTOM COLD FLU",
"Day Relief PE",
"Careone Severe Sinus Congestion",
"Cold and Allergy",
"Cold Relief",
"Cold Relief",
"Multi Symptom Cold Plus Childrens",
"DayQuil Cold and Flu",
"Family wellness hemorrhoidal",
"Hemorrhoidal",
"Sinus Relief",
"Sinus Relief",
"Cold Relief Daytime",
"DayTime Severe Cold and Flu Relief",
"Cold Daytime",
"Mucus Relief Cold and Sinus",
"Cold Multi Symptom",
"Sinus and Allergy Maximum Strength",
"Family Wellness flu and severe cold and cough nighttime",
"Severe Cold Daytime Cold and Flu Nighttime",
"Severe Cold Daytime Cold and Flu Nighttime",
"Cold Relief",
"Cold Relief",
"Hemorrhoidal Cooling",
"Childrens Triacting",
"Allergy Multi Symptom",
"Flu and Severe Cold and Cough Nighttime",
"Cold Relief Non Drowsy",
"Acetaminophen Dextromethorphan HBr Doxylamine succinate Phenylephrine HCl",
"Nitetime Severe Cold and Flu Relief",
"Cold Relief",
"Childrens Mucus Relief Multi Symptom Cold",
"Daytime PE Non Drowsy",
"Sunmark Day Time Cold and Cough Childrens Triacting Formula",
"Mucus Relief Severe Cold",
"Cold Relief",
"Cold Relief",
"Careone Hemorrhoidal",
"Alka-Seltzer Plus Flu Formula",
"Fleet",
"Alka-Seltzer Plus Severe Sinus Congestion and Cough Day and Night",
"Alka-Seltzer Plus Severe Sinus Congestion and Cough Day and Night",
"Day Time with PE",
"Tussin CF",
"Day Time with PE",
"Wal Flu Flu and Sore Throat",
"Childrens Wal Tap DM",
"Hemorrhoidal",
"Hemorrhoidal",
"Smart Sense Hemorrhoidal",
"Equaline Hemorrhoidal",
"Good Sense Cold",
"Good Sense Hemorrhoidal",
"Hemorrhoidal Relief",
"Shoprite Hemorrhoidal",
"Healthy Accents Hemorrhoidal",
"ShopRite Childrens Multi Symptom Cold Relief",
"Daytime Cold and Flu Relief Non Drowsy",
"Daytime Cold and Flu Relief Non Drowsy",
"Hemorrhoidal",
"Hemorrhoidal",
"Up and Up Hemorrhoidal",
"Exchange Select Hemorrhoidal",
"Acetaminophen Dextromethorphan HBr Doxylamine succinate Phenylephrine HCl",
"Good Sense Cold",
"Sinus PE Pressure, Pain plus Cough Multi-Symptom",
"Good Sense Flu and Sore Throat",
"Good Sense Cold",
"Kirkland Signature Cold",
"Good Sense Cold Head Congestion",
"Triaminic Day Time Cold and Cough",
"Tylenol Cold Multi-symptom",
"TYLENOL Cold Multi-Symptom Severe",
"Mucus Relief Cold, Flu and Sore Throat Maximum Strength",
"Smart Sense Flu and Severe Cold and Cough Nighttime",
"Care One Cold Multi Symptom",
"Care One Cold Multi Symptom",
"Care One Cold Head Congestion",
"Care One Cold Head Congestion daytime non-drowsy",
"Sunmark Hemorrhoidal",
"sunmark Cold",
"Care One Cold Multi Symptom",
"Flu and Sore Throat Soothing Warm Relief",
"Donatussin",
"Care One Hemorrhoidal",
"Rx Act Flu and Severe Cold and Cough Nighttime",
"Cold Relief Multi-Symptom",
"Cold Relief Multi-Symptom",
"Smart Sense Hemorrhoidal",
"Hemorrhoidal",
"Hemorrhoidal",
"CareOne Hemorrhoidal",
"Hemorrhoidal",
"Smart Sense Triacting",
"Cold Relief Head Congestion",
"Care One Cold and Allergy",
"Care One Hemorrhoidal",
"ShopRite Allergy",
"Rx Act sinus and allergy PE",
"Sunmark Cold and Allergy",
"Healthy Accents cold head congestion daytime non drowsy",
"Care One Sinus and Allergy PE",
"Donatussin",
"ShopRight Childrens Nighttime Cold and Cough",
"Daytime Non Drowsy",
"Healthy Accents hemorrhoidal",
"Day Time Night Time",
"Rx Act Flu and severe cold and cough daytime",
"Sunmark Cold Head Congestion",
"Donatussin DROPS",
"Flu and Severe Cold and Cough Daytime",
"Care One Cold Head Congestion",
"Care One Cold Head Congestion",
"Flu and Severe Cold and Cough",
"Donatussin DM Drops DM",
"Flu and Severe Cold and Cough daytime",
"Dallergy",
"Sunmark Hemorrhoidal",
"Cold Relief Head Congestion Daytime Non-Drowsy",
"Smart Sense Flu and Severe Cold and Cough Daytime",
"Care One Flu and Sore Throat",
"Care One Flu and Severe Cold and Cough Daytime",
"Non-Drowsy Wal-Phed PE Triple Relief",
"Daytime",
"Tussin CF",
"Flu Relief Therapy Day Time",
"Delsym Night Time Cough and Cold",
"Delsym Childrens Night Time Cough and Cold",
"Allergy and Sinus PE Maximum Strength",
"Cold and Sinus PE Pressure, Pain and Cold Non-Drowsy",
"Harris Teeter Hemorrhoidal",
"Cough and Sinus PE Pressure, Pain and Cough Non-Drowsy",
"Mucus Relief Maximum Strength",
"Day Time",
"Hemorrhoidal",
"Equaline Flu and Severe Cold and Cough",
"Allergy and Cough",
"Flu and Sore Throat",
"Equaline Tussin Cough and Cold",
"Good Neighbor Pharmacy Cold",
"Good Neighbor Pharmacy Cold",
"Topcare Flu and Severe Cold and Cough",
"Topcare Cold Multi Symptom Severe",
"Care One Flu and Severe Cold Daytime",
"Good Neighbor Pharmacy Cold Plus Multi Symptom",
"PediaCare Childrens MultiSymptom Cold",
"Up and Up Cold Flu Relief Multi Symptom Day",
"CareOne Mucus Relief Severe Congestion and Cold",
"Good Neighbor Pharmacy Cold",
"Good Neighbor Pharmacy Cold",
"Equaline Sinus Congestion and Pain Daytime",
"Good Neighbor Pharmacy Cold Head Congestion",
"Allergy Sinus PE Pain Relief",
"Hemorrhoidal",
"Good Neighbor Pharmacy Sinus Congestion and Pain",
"Hemorrhoidal",
"Equaline Childrens Cold",
"Topcare Cold Head Congestion Severe",
"Care One Flu and Severe Cold and Cough Nighttime",
"Equaline Flu and Sore Throat",
"Severe Cold",
"Daytime Cold and Flu Relief",
"Equaline Daytime Cold and Flu Relief",
"Alka-Seltzer Plus Day and Night Cold",
"Alka-Seltzer Plus Day and Night Cold",
"Good Neighbor Pharmacy Cold Head Congestion",
"Topcare Day Time Nite Time",
"Up and Up Sinus Congestion and Pain",
"Equaline Daytime and Nighttime Cold",
"Equaline Daytime and Nighttime Cold",
"Mucinex Fast-Max Severe Cold and Sinus",
"Sinus Congestion and Pain Non-Drowsy, Daytime",
"Smart Sense Multi Symptom Cold",
"Sunmark sinus congestion and pain",
"Mucus Relief Cold and Sinus",
"Mucus Relief cold flu and sore throat",
"Equaline Hemorrhoidal",
"Cleartime",
"Healthy Accents Mucus Relief Severe Congestion and Cold",
"Smart Sense Childrens Multi Symptom Cold Relief",
"Night Time Sinus Congestion and Pain",
"Healthy Accents Sinus Day Time",
"PediaCare Childrens Allergy and Cold",
"Healthy Accents Allergy Multi Symptom",
"Daytime Non Drowsy",
"Healthy accents hemorrhoidal",
"Alka-Seltzer Plus Day Non-Drowsy Cold and Flu Formula",
"Good Neighbor Pharmacy Cold and Allergy PE",
"Flu and Severe Cold and Cough Daytime",
"Daytime Non Drowsy",
"Natureplex Hemorrhoidal",
"Sunmark cold head congestion",
"Good Neighbor Pharmacy Night Time",
"Healthy Accents Cleartime",
"Good Neighbor Pharmacy Cold Severe",
"Mucus Relief Severe Congestion and Cold",
"Hemorrhoidal",
"Theraflu ExpressMax Nighttime Severe Cold and Cough",
"Alka-Seltzer Plus Fast Crystals Packs Cold Formula",
"Maximum Strength Daytime Cold/Flu Relief",
"Quality Choice Effervescent Cold Relief Plus",
"DayTime",
"Vicks Formula 44 Cough and Head Congestion",
"HemorrhoidalOintment",
"Alka-Seltzer Plus Cold Formula (Cherry Burst)",
"Alka-Seltzer Plus Cold Formula (Orange Zest)",
"Adult Tussin Cough and Cold CF",
"Alka-Seltzer Plus Cold and Cough Formula",
"Hemorrhoid Relief",
"Hemorrhoidal",
"Family wellness",
"DAY-TIME Cold and Flu",
"Daytime Sinus Non-Drowsy",
"Triaminic Chest and Nasal Congestion",
"Triaminic Day Time Cold and Cough",
"Mucus Relief Cold, Flu and Sore Throat Maximum Strength",
"Mucus Relief Severe Congestion and Cough Maximum Strength",
"DiBromm with PE",
"Hemorrhoidal",
"Careone Hemorrhoidal",
"CareOne Childrens Cold and Cough",
"Childrens Multi Symptom Cold",
"Hemorrhoidal",
"Altidec A",
"Childrens Plus Multi-Symptom Cold Grape with PE",
"CareOne Triacting Night Time Cold and Cough Childrens",
"Careone Cold Max",
"Notuss PE",
"Mucus Relief Cold, Flu and Sore Throat Maximum Strength",
"Family Dollar Multi-Symptom Severe Cold Green Tea and Honey Lemon flavors",
"Family Dollar Nighttime Severe Cold and Cough honey lemon infused with chamomile and white tea flavors",
"Equate Flu and Severe Cold and Cough",
"Day Time Cold and Flu",
"Cold",
"Sinus and Allergy PE Maximum Strength",
"Cold",
"Cold",
"Cold and Allergy",
"Cold PE",
"Multi-Symptom Cold Relief",
"Multi-Symptom Cold Relief",
"Hemorrhoidal",
"Sinus Congestion and Pain",
"Cold Head Congestion",
"Cold Head Congestion",
"Allergy Pain Relief",
"ClearTime",
"Tussin CF",
"De-Chlor DM",
"Cold and Allergy",
"Hemorrhoidal",
"Pain Relief Cold",
"Severe Cold Cough and Flu",
"Topcare Day Time Nite Time Cold and Flu Relief",
"Little Colds Multi Symptom Cold",
"Childrens Benadryl Allergy Plus Congestion",
"Defensolito",
"PediaCare Childrens Nighttime Multi Symptom Cold",
"Defensol D",
"Sound Body Tussin CF",
"Natureplex Hemorrhoidal",
"Day Time",
"Top Value Effervescent Cold Relief",
"Smart Sense Hemorrhoidal",
"Sinus Congestion and Pain Daytime Non Drowsy",
"Alka-Seltzer Plus Day and Night Multi-Symptom Cold and Flu Formula",
"Alka-Seltzer Plus Day and Night Multi-Symptom Cold and Flu Formula",
"Rx Act sinus congestion and pain",
"Dover Coldonyl",
"Tussin CF Maximum Strength",
"Topcare Sinus Congestion and Pain",
"Topcare Sinus Congestion and Pain",
"Alka-Seltzer Plus Severe Sinus Congestion and Cough Day and Night",
"Alka-Seltzer Plus Severe Sinus Congestion and Cough Day and Night",
"Alka-Seltzer Plus Severe Sinus Congestion and Cough Liquid Gels",
"Alka-Seltzer Plus Severe Sinus Congestion, Allergy and Cough",
"Alka-Seltzer Plus Multi-Smptom Cold and Flu Night",
"Alka-Seltzer Plus Day and Night Cold and Flu Formula",
"Alka-Seltzer Plus Day and Night Cold and Flu Formula",
"Alka-Seltzer Plus Day and Night Cold and Flu Formula",
"Alka-Seltzer Plus Day and Night Cold and Flu Formula",
"Phenylephrine Hydrochloride",
"Flu Relief Therapy Night Time",
"Good Neighbor Pharmacy Cold",
"Childrens Plus Multi-Symptom with PE",
"Promethazine Hydrochloride and Phenylephrine Hydrochloride",
"Advil Congestion Relief",
"Hemorrhoidal",
"PediaCare Multi Symptom Cold",
"Up and Up mucus relief cold, flu and sore throat",
"Daytime Congestion and Pain Sinus Relief",
"Alka-Seltzer Plus Severe Allergy Sinus Congestion And Headache Formula",
"Leader Hemorrholidal",
"Alka-Seltzer Plus Day Severe Cold, Cough And Flu",
"Alka-Seltzer Plus Night Severe Cold, Cough And Flu",
"Equate Daytime Cold and Flu",
"Cold and Chest Congestion Relief",
"Night Time Severe Cold and Cough Relief",
"Cold and Sinus Maxium Strength",
"Daytime Non-Drowsy COLD/FLU",
"Supress A",
"Tusslin TR",
"Leader Cold Head Congestion",
"Leader Night Time Cough and Cold Childrens Triacting",
"Leader Cold Head Congestion",
"Wal Tussin CF Max",
"Leader Cold and Allergy",
"Promethazine VC with Codeine",
"Leader Sinus and Allergy PE",
"Leader Day time Cough and Cold Childrens",
"Humana Pharmacy Hemorrhoidal",
"DayTime Cold and Flu",
"Top Care Flu and Sore Throat",
"TopCare Sinus and Allergy PE Maximum Strength",
"Topcare Day time cold and flu relief",
"Daytime Nitetime",
"DayTime Cold and Flu",
"Hemorrhoidal",
"Cold and Allergy",
"Topcare hemorrhoidal",
"Cough Tussin",
"Topcare Day Time Nite Time",
"Sinus Congestion and Pain",
"Topcare Cold Head Congestion Nighttime",
"topcare Hemorrhoidal",
"Cold Relief Multi Symptom",
"Sinus and Allergy PE Maximum Strength",
"Topcare Cold and Cough",
"Hemorrhoidal Cooling",
"Adult CF Cough",
"Hemorrhoidal",
"Family Wellness Hemorrhoidal",
"Head Congestion",
"Head Congestion",
"TopCare Cold NightTime Multi Symptom",
"lidoForte Hemorrhoidal",
"Top Care Day Time Multi Symptom Relief",
"Topcare Cold Head Congestion",
"Hemorrhoidal",
"Topcare DayTime",
"Cold Relief",
"Topcare Cold and Allergy",
"Cold Relief Head Congestion",
"Flu and Sore Throat Multi Symptom",
"Cold Relief",
"Cold Relief",
"Topcare Hemorrhoidal",
"Cold, Flu and Sore Throat Maxium Strength",
"Mucus Relief Maximum Strength",
"Mucinex Fast-Max Day Severe Congestion and Cough and Night Cold and Flu",
"Mucinex Fast-Max Day Severe Congestion and Cough and Night Cold and Flu",
"Mucus Relief Maximum Strength",
"Mucinex Fast-Max Severe Congestion and Cough",
"Mucinex Fast-Max Day Severe Cold and Night Cold and Flu",
"Mucinex Fast-Max Day Severe Cold and Night Cold and Flu",
"PediaCare Childrens Plus Flu",
"PediaCare Childrens Plus Multisymptom Cold",
"Flu Relief Therapy Night Time",
"Healthy Accents Cold Head Congestion",
"7 Select Cold and Allergy Childrens",
"Rx Act Flu and Sore Throat",
"Cold Relief",
"Cold Relief",
"Healthy Accents Cold",
"Healthy Accents Cold",
"Healthy Accents Hemorrhoidal",
"Healthy Accents Cold Head Congestion",
"Rx Act Hemorrhoidal",
"Healthy Accents Daytime Cold and Flu",
"Healthy Accents Congestion Relief",
"Smart Sense Adults Tussin CF Multi Symptom Cold",
"Smart Sense Tussin CF Adult",
"Rx Act Cold Head Congestion",
"Alka-Seltzer Plus Severe Sinus Congestion and Cough",
"Alka-Seltzer Plus Cold and Cough Formula",
"Flu Relief Therapy Night Time",
"Tussin CF",
"DiBromm with PE",
"Flu Relief Therapy Day Time",
"Day Time with PE",
"Flu Relief Therapy Day Time",
"Flu Relief Therapy Day Time",
"Flu Relief Therapy Night Time",
"Flu Relief Therapy Night Time",
"Flu Relief Therapy Night Time",
"Triacting Day Time with PE",
"Triacting Night Time Cold and Cough",
"Flu Relief Therapy Day Time",
"CareOne Tussin CF Multi Symptom Cold",
"NEXT COLD and FLU DAYTIME",
"Family Wellness Hemorrhoidal",
"Alka-Seltzer Plus Cold and Cough",
"Equaline Hemorrhoidal",
"Hemorrhoidal",
"Childrens TYLENOL COLD Plus FLU",
"Childrens Wal Dryl PE",
"Neo DM DROPS DM",
"Day Time Night Time Cold and Flu",
"Rapid Max Maximum Strength Cool and Clear - Cold, Flu and Sore throat",
"Rapid Max Maximum Strength Cool and Clear - Cold, Severe Congestion and Cough",
"Despec DM",
"Daytime Cold and Flu Lil Drug Store Products",
"Maxichlor PEH DM",
"Alka-Seltzer Plus",
"Hemorrhoidal Soothing Well at Walgreens",
"Hemorrhoid and Fissure Dr. Butler",
"Circle K Daytime Cold and Flu",
"Altipres Pediatric",
"Bio-rytuss",
"Biodesp DM NF",
"Altipres",
"Biocof",
"7 Select Night Time severe cold, cough and flu",
"Deconex",
"Sinus Relief Severe Congestion",
"Alahist DM",
"Deconex DM",
"Alahist LQ",
"Flu and Severe Cold and Cough",
"Select Brand Hemorrhoid",
"Leader",
"Preferred Plus Hemorrhoidal",
"Mucinex Fast-Max Cold, Flu and Sore Throat",
"Daytime Severe Cold and Cough and Nighttime Severe Cold and Cough",
"Daytime Severe Cold and Cough and Nighttime Severe Cold and Cough",
"TopCare Nighttime Cold and Flu Simple Relief",
"DoloMax Cold Cough",
"Up and Up Childrens Multi Symptom Cold Pain Relief Plus",
"Allerfed Cold and Allergy",
"PediaCare Plus Multisymptom Cold",
"Multi Symptom Daytime",
"Sinus Severe Cold Multi-Symptom",
"Topcare Chest Congestion and Sinus Congestion Relief PE",
"Alka-Seltzer Plus Night Cold and Flu Formula",
"Alka-Seltzer Plus Severe Cold, Mucus and Congestion",
"Topcare Cough Cold and Flu Simple Relief",
"topcare tussin CF",
"Coldtac Ultra",
"Dg Health Cold Head Congestion Severe Day Time",
"Medicated Hemorrhoidal CVS",
"Wal-Phed PE Pressure plus Pain plus Cold Daytime, Nighttime, Multi-Symptom",
"Wal-Phed PE Pressure plus Pain plus Cold Daytime, Nighttime, Multi-Symptom",
"Cold Medicine XL-3 for Children",
"Niva-Hist DM",
"Daytime Cold and Flu Relief",
"Multi Symptom Cold",
"Topcare Congestion Relief",
"Flu and Severe Cold and Cough",
"Cold Relief Severe",
"Good Sense cold multi symptom",
"Cough Syrup",
"Severe Cold Multi Symptom",
"Hemorrhoidal",
"Hemorrhoidal",
"Day Time Sinus",
"Good Sense Hemorrhoidal",
"NiteTime Sinus",
"Tussin",
"Cold Relief Multi Symptom",
"Rx Act Tussin CF Cough and Cold",
"Brotapp PE-DM Cough and Cold",
"Relhist BP",
"Alka-Seltzer Plus Severe Cold And Flu Formula",
"RelCof IR",
"Preferred Plus Hemorrhoid",
"Topcare Cold",
"Leader",
"Daytime Nighttime Multi Symptom Cold Flu Relief",
"Leader Mucus Relief Severe Congestion and Cold",
"TopCare Cold Max",
"Equate Childrens Cold and Cough",
"Daytime Sinus Relief and Nighttime Sinus Relief",
"Daytime Sinus Relief and Nighttime Sinus Relief",
"Daytime Sinus Relief and Nighttime Sinus Relief",
"Daytime Sinus Relief and Nighttime Sinus Relief",
"SINUS RELIEF Maximum Strength Daytime and Nighttime Sinus Pain",
"SINUS RELIEF Maximum Strength Daytime and Nighttime Sinus Pain",
"Daytime Sinus Nighttime Sinus Maximum Strength",
"Daytime Sinus Nighttime Sinus Maximum Strength",
"Ala-hist Ac",
"Deconex Ir",
"Deconex Dmx",
"Cold Multi Symptom Severe",
"Topcare Nite Time Cold and Flu",
"Severe Sinus Congestion",
"cold and cough sinus relief PE NON-DROWSY",
"Good Neighbor Pharmacy Hemorrhoidal",
"Equaline Cold and Flu Relief",
"Careone Severe Sinus Congestion and Pain",
"Rexall Hemorrhoidal",
"Good Sense Tussin CF Cough and Cold",
"Wal Tussin CF Cough and Cold",
"Rexall Daytime Nighttime Cold and Flu",
"Flu and Severe Cold and Cough",
"End-A-flu Multi-symptom Severe Cold and Cough Nighttime Formula",
"FLU-MED NIGHTTIME SEVERE COLD and COUGH",
"Sinus Congestion and Pain Non-Drowsy",
"End-A-flu Multi-symptom Severe Cold and Cough Non Drowsy Daytime Formula",
"FLU-MED DAYTIME SEVERE COLD and COUGH non drowsy formula",
"Despec",
"Cold and Cough",
"Cold and Cough",
"Cold and Cough MULTI-SYMPTOM DAYTIME / NIGHTTIME",
"Cold and Cough MULTI-SYMPTOM DAYTIME / NIGHTTIME",
"Tukol A",
"Dallergy",
"Dallergy DROPS",
"Dallergy",
"Childrens TYLENOL COLD Plus FLU",
"Hemorrhoidal Relief",
"CareOne Hemorrhoidal",
"Care One cold head congestion",
"CareOne Mucus Relief",
"Good Sense Hemorrhoidal",
"CareOne Nitetime Severe Cold Flu Relief",
"CareOne Mucus Relief",
"Multi Symptom Cold CF",
"Cold and Flu Relief Daytime",
"Rexall Hemorrhoidal",
"HyVee Health Effervescent Cold Relief",
"Triaminic Day Time Cold and Cough and Night Time Cold and Cough",
"Triaminic Day Time Cold and Cough and Night Time Cold and Cough",
"Sunmark Allergy Multi Symptom",
"Day Time Non-Drowsy Cold - Flu Relief",
"Dg Health Sinus Congestion and Pain",
"DG Health Pain Relief Cold Night Time",
"DG Health cold multi symptom severe",
"Dg Health Mucus Relief",
"NightRelief DayRelief",
"Wal Flu Severe Cold and Cough Daytime",
"Hemorrhoidal",
"Hemorrhoidal",
"Sinus Congestion And Pain Daytime",
"Topcare childrens cold and cough",
"Phenagil CH",
"Cold and Cough",
"TRIAMINIC Night Time Cold and Cough",
"Rexall Hemorrhoidal",
"Cough Formula Cough and Cold",
"Brom Tapp DM",
"Brom Tapp",
"Rexall Hemorrhoidal Cooling Gel",
"Xyralid Hemorrhoidal",
"Topcare mucus relief",
"Effervescent Cold Relief",
"Biodesp DM",
"BioGtuss NF",
"Pentrexcilina",
"Altipres-B",
"Bio-S-Pres DX",
"Childrens Cold and Cough Nighttime",
"Topcare mucus relief cold flu and sore throat",
"Topcare Childrens Mucus Relief Multi Symptom Cold",
"Sinus Headache Maximum Strength",
"Effervescent Cold Relief",
"Bubbles R Better Effervescent Cold Relief",
"Topcare Childrens Cold and Allergy",
"Hemorrhoidal Cream",
"Mucinex Sinus-Max Night Time Congestion And Cough",
"Hemorrhoidal",
"BC Daytime Multi-Symptom",
"Alka-Seltzer Plus Night Cold and Flu Formula",
"Mydriatic-4",
"Childrens Pain Relief Plus Multi Symptom Cold",
"Childrens Allergy Plus Congestion",
"Igualtuss",
"Severe Cough and Congestion",
"Hemorrhoidal",
"Rugby Hemorrhoidal",
"Severe Congestion and Cough/Cold and Flu Daytime/Nighttime/Maximum Strength",
"Severe Congestion and Cough/Cold and Flu Daytime/Nighttime/Maximum Strength",
"Cold and Allergy",
"Hemorrhoidal",
"Pain Relief",
"Hemorrhoidal",
"Pain Relief",
"Sudafed PE Pressure Plus Pain Plus Cough Day",
"Topcare Hemorrhoidal",
"ALKA SELTZER PLUS Cold Day and Night Effervescent",
"Tussin CF Cough and Cold",
"Topcare Hemorrhoidal",
"Bionatuss DXP",
"DayQuil Severe plus Vicks VapoCool",
"Vicks Formula 44 VapoCool Severe Nighttime Cough and Cold",
"Sinex Severe plus Vicks VapoCool",
"Dibromm DM",
"DIBROMM with PE",
"Alka-Seltzer Plus Multi-Symptom Cold and Flu Day Liquid Gels",
"Vicks Sinex",
"Hemorroidal Cooling gel",
"Robafen CF Cough and cold",
"Childrens Multi-symptom Cold",
"Childrens Multi-symptom Cold and Fever Liquid",
"Equate Childrens Multi symptom Cold Nighttime",
"Good Sense Hemorrhoidal",
"Alka-Seltzer Plus Severe Sinus Congestion and Cough Liquid Gels Day",
"Alka-Seltzer Plus Severe Sinus Congestion and Cough Liquid Gels Night",
"CareOne Childrens Cold and Flu",
"Severe Sinus Congestion Relief",
"Topcare Daytime Nitetime Multi Symptom Relief",
"Tylenol Sinus Severe",
"Tylenol Cold Plus Flu Severe Severe",
"Lil Drug Store Multi-Symptom Sinus Relief",
"Lil Drug Store Multi-Symptom Sinus Relief",
"Alka-Seltzer Plus Cold Medicine Sparkling Original",
"Leader Hemorrhoidal",
"Topcare Hemorrhoidal",
"Promethazine Vc With Codine",
"Promethazine Vc",
"Mucus Relief Complete",
"Acta Tabs PE",
"Suphedrine PE",
"Suphedrine PE",
"Dallergy DROPS",
"Dallergy",
"Multi-Symptom Cold Relief",
"Multi-Symptom Cold Relief",
"Daytime Sinus Pain and Congestion Relief",
"Next Day Time Non drowsy Cold and Flue",
"Daytime Cold and Flu Relief",
"Premier Value Multi-Symptom Severe Cold Green Tea and Honey Lemon flavors",
"CareOne Cold and Sinus",
"Rugby Hemorrhoidal",
"Assured Night time Cold and Cough",
"Omidria",
"Rexall Hemorrhoidal",
"Mucus Relief Severe Congestion and Cough Maximum Strength",
"CareOne Nighttime Severe Cold and Flu",
"BC Sinus Congestion and Pain",
"Sinus Congestion and Pain",
"Sinus Congestion and Pain",
"Major Prep Hemorrhoidal",
"Alka-Seltzer Plus Cold Sparkling Original",
"Mucinex Fast-Max Severe Congestion and Cough",
"Promethazine Hydrochloride, Phenylephrine Hydrochloride and Codeine Phosphate",
"Nighttime Severe Cold and Flu",
"NightTime Severe Cold and Flu",
"Severe Cough and Congestion",
"MAX Cold, Flu, and Sore Throat",
"Good Neighbor Pharmacy Night Time Severe",
"Day-Time NON-DROWSY COLD/FLU RELIEF",
"Best Choice Effervescent Cold Relief",
"Severe Cold and Flu",
"Alka-Seltzer Plus Multi-Symptom Cold and Cough",
"Alka-Seltzer Plus Multi-Symptom Cold Night",
"Signature Care Nighttime Severe Cold and Flu Relief",
"Careone Childrens Multi Symptom Fever and Cold",
"Nitetime Cold and Flu",
"Mucinex Fast-Max Congestion and Headache",
"Theraflu Daytime Severe Cold and Cough",
"Nighttime severe",
"Cold Multi-Symptom",
"Cold Multi-Symptom",
"Dg Health Cold and Flu",
"Despec EDA Drops",
"DG Health Hemorrhoidal",
"Tussin CF",
"Equaline Nighttime Severe Cold and Flu",
"Despec",
"HEB Maximum Strength Pain Relief Hemorrhoidal",
"BC Sinus Congestion and Pain",
"Severe Cold and Flu",
"Dg Health Triacting Night Time Cold and Cough",
"HEB HEMORRHOIDAL COOLING Gel",
"XL-3 Day Time",
"XL-3 Day Time",
"Cold and Flu Day Time Multi-Symptom Relief",
"Day Time Non Drowsy",
"HEB Hemorrhoidal",
"Signature Care Non drowsy Daytime Severe Cold and Flu Relief",
"Dg Health Cold and Flu Severe",
"Cold Preparation For Cough and Sinus Relief",
"Cold Preparation",
"DayTime Nitetime cold and flu relief",
"Tussin Maximum Strength",
"Good Neighbor Pharmacy Tussin CF Max",
"Rexall Daytime Nighttime Cold Flu",
"TopCare Day Time Nite Time Cold and Flu Relief",
"Gilphex TR",
"Tylenol Cold Max Night",
"TYLENOL Cold Plus Mucus Severe",
"DS Never Cold S",
"Topcare Nite Time Cold and Flu",
"Multi Symptom Cold",
"Hemorroidal Cooling gel",
"Dilotab II",
"DAYTIME NIGHTTIME Cold and Flu",
"Vicks DayQuil Severe Cold and Flu",
"Childrens Triacting",
"Severe Cold and Flu",
"Hemorrhoidal",
"Dimaphen",
"Allerfed",
"Severe Cold Cough and Flu",
"TYLENOL Cold plus Flu plus Cough Day",
"Sinus Congestion and Pain",
"Childrens mucus relief",
"Bactimicina Cough and Cold",
"Mucinex Sinus-Max Pressure, Pain and Cough",
"Severe Nighttime",
"Sinus Congestion and Pain Severe",
"DG Health adult tussin multi symptom cold",
"Severe Cold Cough and Flu",
"Harris Teeter DayTime NightTime",
"Equate Nitetime Severe",
"Severe Cold and Flu",
"Childrens Nighttime Cold and Cough",
"Careone daytime severe cold and flu",
"Severe Daytime",
"Daytime Severe Cold and Flu",
"Mucus Relief cold and sinus",
"Day Night Cold and Flu",
"Up and Up severe cold and flu daytime",
"Olp Hemorrhoidal Cooling",
"Equate DayTime Severe",
"Daytime Nighttime",
"Equate DayTime NiteTime",
"Cold and Flu Multi-Symptom Nighttime Severe",
"Facol Cold and Flu Day and Night",
"Facol Cold and Flu Day",
"Theraflu ExpressMax Daytime Severe Cold and Cough",
"Facol Cold and Flu Night",
"Daytime Cold and Flu",
"Daytime cold and flu non drowsy",
"Daytime Cold and Flu Relief",
"Daytime Cold and Flu Relief Non Drowsy",
"Daytime Nighttime Cold Flu Relief",
"DayTime Nighttime",
"Delsym Cough Plus Cold Night Time",
"Hemorrhoidal",
"Daytime Fast Severe Cold Relief Nitetime Fast Cold and Flu Relief",
"Daytime Fast Severe Cold Relief Nitetime Fast Cold and Flu Relief",
"Mucinex Childrens Multi-Symptom Cold and Sore Throat",
"Delsym Cough Plus Cold Day Time",
"Nighttime Severe Cold and Flu Relief",
"Mucinex Childrens Multi-Symptom Cough, Cold and Fever",
"Fast Cold and Flu Relief",
"Daytime Cold and Flu",
"Mucinex Sinus-Max Severe Congestion Relief",
"Daytime Nighttime Severe Cold and Flu Relief",
"Daytime Nighttime Severe Cold and Flu Relief",
"Neogen-D",
"Childrens Wal Tap DM Cough and Cold",
"Childrens Cold and Allergy",
"Cold and Allergy Childrens",
"Fast Cold and Flu Relief",
"Pentrexcilina",
"Daytime PE",
"Mucinex Sinus-Max Pressure and Pain",
"Mucinex Sinus-Max Pressure and Pain",
"Daytime sinus",
"Cold and Cough DM",
"Walgreens Maximum Strength Hemorrhoidal",
"Daytime Nighttime Cold Flu Relief",
"Good Neighbor Pharmacy Cold and Allergy Childrens",
"Equate NiteTime DayTime",
"TUSSIN CF NIGHTTIME COUGH and COLD",
"Leader Severe Cold and Flu",
"Mucinex Fast-Max Severe Cold",
"Alka-Seltzer Plus Maximum Strength Cold and Cough Liquid Gels with Cool Menthol Flavor Liquid Gels",
"Tylenol Sinus Severe",
"Mucinex Fast-Max Day Time Cold and Flu and Night Time Cold and Flu",
"Mucinex Fast-Max Day Time Cold and Flu and Night Time Cold and Flu",
"Leader Tussin CF",
"Good Neighbor Pharmacy Severe Sinus Congestion",
"Mucinex Fast-Max Severe Congestion and Cough",
"Leader Day Time",
"Childrens Flu Relief",
"Daytime Cold and Flu Relief",
"Severe Sinus",
"Severe Cold and Flu Relief",
"Delsym Cough Plus Cold Day Time",
"Equaline Daytime Severe Cold Fast Relief Nighttime Cold and Flu Fast Relief",
"Equaline Daytime Severe Cold Fast Relief Nighttime Cold and Flu Fast Relief",
"Childrens Cold and Cough",
"Equaline Daytime and Nighttime Cold and Flu Relief",
"Mucinex Fast-Max Day Time Severe Cold and Mucinex Fast-Max Night Time Cold and Flu Maximum Strength",
"Mucinex Fast-Max Day Time Severe Cold and Mucinex Fast-Max Night Time Cold and Flu Maximum Strength",
"Cold Multi Symptom",
"Equaline mucus relief",
"Childrens Mucinex Congestion and Cough",
"Equaline Childrens Cold and Cough",
"Multi Symptom Cold CF",
"Mucinex Fast-Max Severe Congestion and Cough Clear and Cool and Mucinex Fast-Max Night Time Cold and Flu Clear and Cool",
"Mucinex Fast-Max Severe Congestion and Cough Clear and Cool and Mucinex Fast-Max Night Time Cold and Flu Clear and Cool",
"Mucinex Sinus-Max Severe Congestion Relief",
"Day time cold and flu",
"Flu Relief Therapy Daytime",
"Daytime Non Drowsy",
"Leader Mucus Relief",
"Leader Childrens Mucus Relief Multi Symptom Cold",
"Childrens Cold and Allergy",
"ShopRite Childrens Cold and Allergy",
"Childrens Plus Multi Symptom Cold Dye Free",
"Childrens Mucinex Multi Symptom Cold and Childrens Mucinex Night Time Multi Symptom Cold",
"Childrens Mucinex Multi Symptom Cold and Childrens Mucinex Night Time Multi Symptom Cold",
"Tussi Pres Pediatric",
"ShopRite Childrens Cold and Cough",
"ShopRite Day Calm",
"Cold and Flu",
"Nighttime Severe",
"Effervescent Cold Relief",
"Severe Cold Head Congestion",
"Childrens Cold and Allergy",
"Sinus",
"Multi Symptom Cold Relief Childrens",
"Mucus Relief Cold, Flu and Sore Throat Maximum Strength",
"Day Time Cold Flu Relief",
"Daytime Nighttime Multi Symptom Cold and Flu Relief",
"Cold",
"Harris Teeter DayTime NightTime",
"Nighttime Flu Relief Therapy Severe Cold",
"Harris Teeter Sinus Relief",
"Harris Teeter Sinus Relief",
"Childrens Triacting Night Time Cold and Cough",
"Severe Cold and Flu",
"Daytime Nighttime cold and flu relief",
"Severe Daytime",
"Triacting Day Time Cold and Cough Childrens",
"Cold and Flu Plus",
"Cold and Flu Plus",
"Severe Cold and Cough Relief Daytime",
"Pressure and Pain PE",
"Cold and Cough childrens",
"Nighttime Cold Multi-Symptom Cool Blast",
"Preferred Plus Severe Nite Time",
"Allergy Multi-Symptom",
"Flu Relief Therapy Nighttime",
"Sanaflu Xtra",
"Mucinex Fast-Max Day Time Severe Congestion and Cough and Mucinex Fast-Max Night Time Cold and Flu Maximum Strength",
"Mucinex Fast-Max Day Time Severe Congestion and Cough and Mucinex Fast-Max Night Time Cold and Flu Maximum Strength",
"Up and Up Cold Flu Relief",
"Flu Relief Cold and Chest Congestion",
"Up and Up Daytime Nighttime Cold and Flu",
"Preparation H",
"Supress DX Pediatric Drops",
"Cold and Allergy Childrens",
"Dristan Cold Multisymptom",
"Careone Day Severe Cold Night Cold and Flu",
"Careone Day Severe Cold Night Cold and Flu",
"SUPRESS-PE Pediatric",
"Preparation H Cooling Gel",
"Dimaphen DM",
"Healthy Accents Cold and Allergy Childrens",
"Healthy Accents Mucus Relief Severe Cold",
"Healthy Accents Cold and Flu",
"DG Health Mucus Relief",
"Healthy Accents Sinus Relief",
"Healthy Accents Sinus Congestion and Pain Day Time",
"Healthy Accents Sinus Relief",
"Healthy Accents Sinus Relief",
"Healthy Accents Childrens Cold and Cough",
"Healthy Accents Childrens Multi Symptom Fever and Cold",
"Healthy Accents Daytime Nighttime Cold and Flu",
"Healthy Accents Daytime Nighttime Cold and Flu",
"Healthy Accents Mucus Relief cold and sinus",
"Healthy Accents Daytime",
"DG Health Fast Acting Mucus Relief Severe Cold",
"DG Health Cold Max",
"DayTime NightTime Sinus Relief",
"DayTime NightTime Sinus Relief",
"Mucinex Fast Max Day Time Severe Congestion and Cough and Night Time Cold and Flu",
"Mucinex Fast Max Day Time Severe Congestion and Cough and Night Time Cold and Flu",
"Dg Health Cold and Allergy Childrens",
"Daytime Nighttime Sinus Relief",
"Daytime Nighttime Sinus Relief",
"DG Health Childrens Cold and Cough",
"Comtrex Cough and Cold Day/Night",
"Comtrex Cough and Cold Day/Night",
"Effervescent Orange Cold Relief",
"Nikzon Hemorrhoidal",
"Daytime Cold Flu multi Symptom",
"Day Time Cold and Flu Relief",
"Multi- Symptom Relief DayTime",
"Effervescent Orange Cold Relief",
"Dg Health Cold and Flu Relief",
"Mucinex Fast-Max Day Time Severe Congestion and Cough and Mucinex Fast-Max Night Time Cold and Flu Maximum Strength",
"Mucinex Fast-Max Day Time Severe Congestion and Cough and Mucinex Fast-Max Night Time Cold and Flu Maximum Strength",
"Kroger Effervescent Cold Relief",
"Severe Cold and Cough Relief Daytime",
"Daytime Sinus Relief Non Drowsy",
"Day Time Cold and Flu Multi-Symptom Relief",
"Non Drowsy Day Time cold and Flu Relief",
"Equaline Effervescent Cold Relief",
"Hemorrhoidal",
"BioTPres Pediatric",
"Biocotron-D",
"BioGtuss",
"Healthy Accents Daytime Nighttime Cold and Flu",
"Signature Care Childrens Cold and Cough",
"Bio-B Kids",
"BioTPres",
"Healthy Accents Mucus Relief cold flu and sore throat",
"CVS Hemorrhoidal",
"Biobron DX",
"Mucinex Sinus-Max Day Time Severe Congestion Relief and Mucinex Sinus-Max Night Time Congestion and Cough Maximum Strength",
"Mucinex Sinus-Max Day Time Severe Congestion Relief and Mucinex Sinus-Max Night Time Congestion and Cough Maximum Strength",
"Nighttime Sinus Relief",
"Day time cold and flu",
"Good Sense Cold and Flu Severe",
"Good Sense Childrens Cold and Allergy",
"Tusicof",
"Smart Sense NightTime DayTime",
"Quality Choice Multi-Symptom, Non-Drowsy DayTime Cold and Flu",
"Childrens Triacting Nighttime Cold and Cough",
"Smart Sense Multi Symptom Fever and Cold Childrens",
"Smart Sense Cold and Allergy Childrens",
"Smart Sense Cold and Cough",
"Daytime Nighttime Cold Flu Relief",
"Tussi Pres",
"G-Supress DX",
"Severe Cold and Cough Relief Daytime",
"Daytime Cold and Flu Relief",
"Actidom Dmx",
"Childrens Multi-Symptom Cold Plus Dye-Free",
"Childrens Plus Cold",
"Flu Relief Therapy Nighttime",
"Good Sense Childrens Cold and Cough",
"Presgen Pediatric",
"Good Sense NightTime DayTime Cold and Flu",
"Day Time PE cold and flu relief",
"Day Time Cold and Flu",
"Sinus and Allergy",
"DayRelief Multi symptom",
"Allerfed Cold and Allergy PE",
"Healthy Accents Multi Symptom Cold",
"Good Sense Severe NightTime",
"Day Relief Sinus PE",
"Cold Relief Multi-Symptom",
"Cold Relief Multi-Symptom",
"Tussin CF",
"Severe Allergy Relief Plus Sinus Headache",
"Pressure Plus Pain PE Plus Cold",
"MAXIUM STRENGTH SEVERE CONGESTION and COUGH MAX",
"Pressure plus Pain PE",
"PRESSURE plus PAIN plus MUCUS",
"Mucus Relief Sinus Severe Congestion Relief",
"Flu Relief Therapy Nighttime",
"Childrens Plus Cold",
"Mucus Relief Severe Congestion and Cough Maximum Strength",
"Allergy Multi-Symptom",
"Cold and Flu Severe",
"Sinus Severe",
"Severe Cold PE",
"Mucus Relief Cold and Sinus Maximum Strength",
"Pressure plus Pain PE plus Mucus",
"Tussin CF Adult",
"Cold and Head Congestion Severe",
"Severe Cold Head Congestion",
"Smart Sense Daytime Nighttime Cold and Flu",
"Childrens Plus Flu",
"Cold Head Congestion Daytime",
"Cold Multi-Symptom Daytime",
"Severe Cold and Flu",
"Mucus Relief Day Time and Night Time",
"Mucus Relief Day Time and Night Time",
"Allergy Multi-symptom",
"Mucus Relief Cold, Flu and Sore Throat",
"Severe Cold and Flu Relief",
"Night Relief sinus",
"Mucus Relief Severe Cold",
"Daytime Multi-symptom Cold Relief",
"Leader Nighttime Sever Cold and Flu",
"Sinus Congestion and Pain Severe",
"Severe Sinus Congestion and Pain",
"Mucus Relief Sinus Pressure and Pain",
"Pressure and Pain PE plus Cough",
"Pressure Pain Mucus PE",
"Severe Allergy Relief Plus Sinus Headache",
"Pressure and Pain PE Plus Mucus",
"Sinus Congestion and Pain",
"Pressure and Pain PE Plus Cold",
"Allergy Multi-Symptom",
"TopCare Pain Relief Cold Nightttime",
"Tussin CF",
"Mucus Relief Cold, Flu, Sore Throat Maximum Strength",
"Panadol Cold and Flu NonDrowsy",
"Daytime Nighttime Cold Flu Relief",
"Careone Daytime Nighttime Severe Cold and Flu",
"Careone Daytime Nighttime Severe Cold and Flu",
"Topcare Day Time",
"NightTime DayTime Severe Cold and Flu",
"NightTime DayTime Severe Cold and Flu",
"Day Time Night Time Severe Cold and Flu",
"Day Time Night Time Severe Cold and Flu",
"Theraflu Powerpods Nighttime Severe Cold",
"Severe Nighttime Severe Daytime",
"Severe Nighttime Severe Daytime",
"Signature Care daytime nighttime severe cold and flu relief",
"Signature Care daytime nighttime severe cold and flu relief",
"Severe Cold and Flu",
"Severe Cold and Flu",
"NiteTime DayTime Cold and Flu",
"NiteTime DayTime Cold and Flu",
"Up and Up severe cold and flu",
"Up and Up severe cold and flu",
"Theraflu PowerPods Daytime Severe Cold",
"Sinus Severe",
"Dollar General Effervescent Cold Relief",
"Mucinex Childrens Stuffy Nose and Chest Congestion",
"Mucinex Childrens Multi-Symptom Cold",
"Mucinex Childrens Night Time Multi-Symptom Cold",
"Equate DayTime NiteTime Severe",
"Equate DayTime NiteTime Severe",
"Childrens Dimetapp Cold and Cough",
"Childrens Dimetapp Cold and Allergy",
"Equate Hemorrhoidal",
"Childrens Multi Symptom Cold",
"Tylo Cold and Flu Day",
"Preparation H Rapid Relief",
"Equate Hemorrhoidal",
"Cold and Cough",
"Hemorrhoidal Cream",
"Equate Hemorrhoidal",
"Sinus Relief Non Drowsy",
"Cold and Cough",
"Allergy Relief Plus Sinus Headache",
"Hemorrhoidal",
"Shoprite Ni Calm",
"Mucus Relief Severe Congestion and Cough Maximum Strength",
"Mucus Relief Cold Flu and Sore Throat Maximum Strength",
"Daytime Nitetime Cold and Flu",
"Childrens Cough and Cold",
"Daytime Cough",
"Congestion and Headache",
"Daytime Mucus Relief Severe Cold and Nighttime Cold and Flu Maximum Strength",
"Daytime Mucus Relief Severe Cold and Nighttime Cold and Flu Maximum Strength",
"Basic Care Mucus Relief Severe Congestion and Cough",
"Robitussin Severe Multi-Symptom Cough Cold Flu",
"Cold Medicine XL3 FORTE",
"Cold Medicine XL3 FORTE",
"Cold Medicine XL3 FORTE",
"Cold Flu and Sore Throat",
"Mucus Relief Cold Flu Sore Throat Maximum Strength",
"Mucus Relief Severe Sinus Congestion",
"Daytime Nighttime Sinus Relief Maximum Strength",
"Daytime Nighttime Sinus Relief Maximum Strength",
"Daytime Mucus Relief Severe Cold Nighttime Cold and Flu Maximum Strength",
"Daytime Mucus Relief Severe Cold Nighttime Cold and Flu Maximum Strength",
"DayTime Cold and Flu Non Drowsy",
"Daytime PE Nitetime",
"Pressure Pain Cold PE",
"Leader Cold and Flu",
"Leader Cold Relief",
"Leader Mucus Relief Cold Flu and Sore Throat",
"Effervescent Cold Relief",
"Leader severe cold and flu",
"Leader Childrens Cold and Cough",
"Leader Mucus Relief Sever Cold",
"Cold Multi-Symptom",
"Leader Childrens Cold and Allergy",
"Day Time Cold and Flu Non drowsy",
"Leader Mucus Relief Cold Flu and Sore Throat",
"Cold and Allergy",
"Leader Flu and Severe Cold and Cough",
"Cold and Flu Severe Daytime and Nighttime",
"Cold and Flu Severe Daytime and Nighttime",
"Leader mucus relief cold and sinus",
"Mapap Sinus Congestion and Pain Maximum Strength",
"Mucus Relief Daytime Severe Cold Nighttime Cold and Flu Maximum Strength",
"Mucus Relief Daytime Severe Cold Nighttime Cold and Flu Maximum Strength",
"Day Time Multi-Symptom Cold/Flu Relief",
"Severe Cold Daytime",
"Cold Flu and Sore Throat Maximum Strength",
"Daytime Nighttime Sinus Relief Maximum Strength",
"Daytime Nighttime Sinus Relief Maximum Strength",
"Childrens Dimetapp Multi-Symptom Cold Relief Dye-Free",
"Daytime Cold Flu",
"Basic Care Daytime Cold and Flu",
"Basic Care Childrens Cold Plus Flu",
"Effervescent Orange Cold Relief",
"Wal Tussin CF Max Multi Symptom Cough Cold and Flu",
"Basic Care Daytime Severe Cold Nighttime Cold and Flu",
"Basic Care Daytime Severe Cold Nighttime Cold and Flu",
"Topcare Day Time Nite Time Cold and Flu",
"Topcare Day Time Nite Time Cold and Flu",
"Basic Care Daytime Nighttime Severe Cold and Flu",
"Basic Care Daytime Nighttime Severe Cold and Flu",
"Allerfed Cold and Allergy",
"Sinus Pressure and Pain Relief maximum strength",
"Basic Care Daytime Cold and Flu Severe",
"Basic Care daytime nighttime severe cold and flu",
"Basic Care daytime nighttime severe cold and flu",
"Mucus Relief Severe Congestion and Cough Maximum Strength",
"Sinus Congestion and Pain",
"Day Severe Cold Night Cold and Flu",
"Day Severe Cold Night Cold and Flu",
"Lil Drug Store Multi-Symptom Sinus Severe Congestion",
"Daytime Nighttime",
"Sinus and Allergy PE",
"Hemorrhoid and Fissure Dr. Butler",
"Effervescent Orange Cold Relief",
"Signature Care Hemorrhoidal",
"Mucinar PLUS",
"Mucinar PLUS",
"Daytime Cold and Flu",
"Febrix Kids PLUS",
"Mucinar Kids PLUS",
"Robitussin Peak Cold Multi-Symptom Cold",
"Cold Head Congestion Daytime",
"Cold and Flu Severe",
"Childrens Robitussin Cough and Cold CF",
"Daytime Nighttime Cold Flu Relief",
"TopCare Health Non Drowsy Daytime Cold and Flu Relief And Nighttime Cold and Flu Relief Day and Night Combo Pack",
"Hemorrhoidal",
"Hemorrhoidal",
"Topcare Nite Time Day Time Cold and Flu",
"Contac Gold",
"Ed A-hist",
"Tussin Multi Symptom Cold CF Adult",
"Night Time Cold and Flu",
"Day Severe Cold and Night Cold and Flu Maximum Strength",
"Day Severe Cold and Night Cold and Flu Maximum Strength",
"VanaTab DM",
"Basic Care Daytime Cold and Flu",
"Giltuss Allergy Plus Cough and Congestion",
"Giltuss Cough and Cold",
"Doc in the Box All Day Supply",
"Giltuss MultiSymptom Cold and Flu",
"Up and Up Hemorrhoidal",
"Pharbinex-PE",
"Effervescent Cold Relief - Orange",
"Good Sense Day Time Night Time Cold and Flu",
"Good Sense Day Time Night Time Cold and Flu",
"NightTime Cold and Cough Children",
"Meds on the Go",
"Giltuss Childrens Allergy Plus Cough and Congestion",
"Giltuss Childrens MultiSymptom Cold and Flu",
"Cold and Flu Daytime",
"Giltuss Childrens Cough and Cold",
"Preparation H Rapid Relief",
"Cold and Flu Daytime Relief",
"Smart Sense Effervescent Cold Relief",
"Theraflu ExpressMax Nighttime Severe Cold and Cough",
"Triacting Daytime Cold Cough Childrens",
"Giltuss Cough and Cold",
"DayTime Cold and Cough Childrens",
"Giltuss Allergy Plus",
"Giltuss Sinus and Chest Congestion",
"Theraflu ExpressMax Daytime Severe Cold and Cough",
"SanaTos X",
"Hemorrhoidal Cream",
"Childrens Night Time Cold and Cough",
"Childrens Nighttime Cold and Cough",
"Mucus Relief Cold Flu Sore Throat Maximum Strength",
"Allergy Multi-Symptom",
"Mucus Relief Severe Cough and Congestion",
"Mucus Relief Severe Congestion Cough Maximum Strength",
"DayTime Cold and Flu",
"Flu Relief Therapy Night Time",
"Theraflu Flu and Sore Throat",
"Day Time with PE",
"Severe Wal Tussin CF Max",
"Green Guard Advanced Sinus Relief",
"Topcare Childrens Night Time Cold and Cough",
"VIcks Flu Therapy Severe Cold and Flu Day",
"VIcks Flu Therapy Severe Cold and Flu Day",
"VIcks Flu Therapy Severe Cold and Flu Night",
"VIcks Flu Therapy Severe Cold and Flu Night",
"Good Sense Tussin CF",
"Severe Cold and Flu",
"Vicks childrens Cough Congestion Night",
"Vicks Cough and Congestion PM",
"Vicks childrens Cough Congestion",
"Allergy Plus Congestion",
"Sinus Relief Congestion and Pain Daytime",
"Vicks Childrens Cold Multi Symptom",
"Vicks Cough and Cold Severe",
"Vicks Cough and Congestion DM",
"Daytime/Nighttime Cold and Flu Multi-Symptom Relief",
"Sinus and Allergy Relief",
"Poly-Hist DM",
"Alahist DM",
"Cold Multi-Symptom Severe",
"Mucus Relief All in One Maximum Strength",
"SUDAFED PE Pressure Plus Pain",
"Daytime Nighttime cold and flu relief",
"Recticare Advanced",
"Day and Night Sinus Maximum Strength",
"Day and Night Sinus Maximum Strength",
"Cold Head Congestion Daytime Non-Drowsy",
"Otis Clapp Emagrin Forte",
"Daytime Cold and Flu Nitetime Cold and Flu",
"Daytime Cold and Flu Nitetime Cold and Flu",
"Daytime Cold and Flu",
"Cold FAid",
"Cold and Allergy childrens",
"NyQuil Severe plus Vicks VapoCool Cold and Flu",
"Cold and Cough Childrens",
"Maximum Strength Nighttime Cold and Flu",
"Daytime Cold and Flu Non Drowsy",
"Sinus and Allergy",
"Cold, Flu and Sore Throat Maximum Strength",
"Severe Congestion and Cold Maximum Strength",
"Dye Free Cold and Flu",
"NyQuil Severe Plus VapoCOOL Cold and Flu",
"Basic Care Mucus Relief Cold Flu and Sore Throat",
"DayQuil Severe Plus VapoCOOL Cold And Flu",
"Cold, Flu, and Sore Throat",
"Cold Flu and Sore Throat",
"Severe Cold Plus Flu Daytime Nighttime",
"Severe Cold Plus Flu Daytime Nighttime",
"Cold Flu and Sore Throat",
"Dibucaine HCl 0.5% / Lidocaine 15% / Phenylephrine HCl 1% / Prilocaine 5%",
"Daytime Cold Cough Childrens",
"Multi Symptom Severe Cold and Nighttime Severe Cold and Cough",
"Multi Symptom Severe Cold and Nighttime Severe Cold and Cough",
"Daytime Nighttime Cold and Cough Childrens",
"Daytime Nighttime Cold and Cough Childrens",
"Nighttime Cold and Cough childrens",
"Numb520",
"Triacting Daytime Cold Cough Childrens",
"Mucinex Childrens Cold and Flu",
"Cold and Sinus Maximum Strength, Multi-Symptom",
"Basic Care Daytime Nighttime Cold and Flu",
"Basic Care Day Time Night Time Cold and Flu",
"Basic Care Day Time Night Time Cold and Flu",
"Sinus Relief Day Night",
"Sinus Relief Day Night",
"Cold and Allergy",
"Mucus Relief Severe Congestion and Cough",
"Daytime",
"Cold and Flu Severe Daytime Nighttime",
"Cold and Flu Severe Daytime Nighttime",
"Triacting Daytime Cold Cough Childrens",
"Mucinex Childrens Cough and Congestion",
"Mucinex Junior Cold and Flu",
"Multi Symptom Cold and Multi Symptom Nighttime Cold Childrens",
"Multi Symptom Cold and Multi Symptom Nighttime Cold Childrens",
"Equate Effervescent Cold Relief",
"Only For COLD AND FLU COUGH SUPPRESSANT",
"Basic Care Daytime Severe Cold Nighttime Cold and Flu",
"Basic Care Daytime Severe Cold Nighttime Cold and Flu",
"Nighttime Severe Cold and Cough",
"Mucus Relief Nighttime Cold Flu Maximum StrengthCold Flu and Sore Throat",
"Actinel DM",
"Mucinex Childrens Day Time Multi-Symptom Cold and Night Time Multi-Symptom Cold",
"Mucinex Childrens Day Time Multi-Symptom Cold and Night Time Multi-Symptom Cold",
"Walgreens Effervescent Cold Relief Plus",
"Sinus Congestion and Pain",
"Night time Multi Sympton Cold Max",
"Severe Cold and Cough Daytime",
"Ortizol Otic Solution",
"Alka-Seltzer Plus Severe Sinus Congestion Allergy and Cough",
"Alka-Seltzer Plus Cold and Cough Cool Menthol",
"CVS Daytime Severe Cold and Flu Relief Softgels",
"Daytime Cold and Flu Non Drowsy",
"Daytime Nighttime Cold and Flu Relief Multi-Symptom",
"CVS Health Maximum Strength Non Drowsy Day and Night Cold and Flu Max Softgels Minis",
"CVS Health Maximum Strength Non Drowsy Day and Night Cold and Flu Max Softgels Minis",
"CVS Health Non Drowsy DAY Cold and Flu Plus and NIGHTTIME Cold and Flu Plus",
"CVS Health Non Drowsy DAY Cold and Flu Plus and NIGHTTIME Cold and Flu Plus",
"Tusnel DM",
"Tusnel Pediatric DM",
"Ala-hist PE",
"Poly Hist Forte",
"Daytime Nighttime Cold and Flu Relief Multi-Symptom",
"Mucus Relief Severe Congestion and Cough Maximum Strength",
"Hemorrhoidal",
"Signature Care Hemorrhoidal",
"Daytime Cold and Flu Non Drowsy",
"Palagrip",
"Sudafed PE Head Congestion Plus Pain",
"Mucinex Nightshift Cold and Flu Clear and Cool",
"Mucinex Nightshift Sinus",
"Sudafed PE Sinus Pressure Plus Pain",
"Mucinex Nightshift Sinus Clear and Cool",
"Sudafed PE Sinus Congestion",
"Sudafed PE Sinus Congestion",
"Cold Multi-Symptom, Daytime",
"Tylenol Cold plus Flu plus Cough Night",
"Signature Care Hemorrhoidal",
"DayTime NightTime Cold and Flu",
"Daytime Cold Flu Relief",
"Daytime Nighttime Multi Symptom Cold Childrens",
"Daytime Nighttime Multi Symptom Cold Childrens",
"DayTime Cold Flu Non-Drowsy",
"Daytime cold and flu relief",
"DAYTIME cold and flu relief",
"Cold and Flu Relief Multi symptom",
"DayTime NightTime Cold/Flu",
"DayTime NiteTime Cold Flu Relief",
"Daytime Nighttime Cold and Flu Relief Multi-Symptom",
"COLD and FLU DAYTIME MAXIMUM STRENGTH NON-DROWSY SEVERE",
"DayQuil Severe plus Vicks VapoCool Cold and Flu",
"Cold and Flu Relief Multi symptom",
"Daytime Flu Relief Therapy",
"COLD, Flu and Sore Throat",
"Childrens Dibromm Cold and Cough",
"Childrens Dibromm Cold and Allergy",
"Phenagil",
"Theraflu ExpressMax Flu, Cough, and Sore Throat",
"Equaline Mucus Relief",
"Daytime Nighttime Cold Flu Relief",
"Cold Relief Multi Symptom Nighttime",
"Mucus Relief Congestion and Headache Maximum Strength",
"Basic Care Nighttime Cold and Flu Severe",
"Giltuss D Allergy and Congestion",
"LIDL Daytime Cold and Flu Relief Multi Symptom",
"Basic Care Daytime Nighttime Cold and Flu",
"Basic Care Daytime Nighttime Cold and Flu",
"Severe Cold and Flu",
"Mucus Relief Cold Flu Sore Throat Maximum Strength",
"Hemorrhoidal Cream with Aloe",
"Triacting Day Time with PE",
"Allergy Multi-Symptom",
"Alka Seltzer Plus Cold",
"Triacting Daytime Cold Cough Childrens",
"Sinus Congestion and Pain Daytime Non-Drowsy",
"Daytime and Nighttime Sinus Congestion PE",
"Daytime and Nighttime Sinus Congestion PE",
"NyQuil Severe plus Vicks VapoCool",
"Vicks DayQuil Cold and Flu Multi-Symptom Relief",
"Vicks NyQuil Severe Cold and Flu",
"Sinex",
"Vicks NyQuil Severe Cold and Flu",
"DayQuil Severe",
"Sinus and Allergy PE maximum strength",
"Childrens Cold and Cough",
"Tussin Multi Symptom Cold CF",
"Daytime Cold and Flu Multi-symptom Relief",
"Vicks NyQuil Severe Cold and Flu",
"Cold and Flu Multi-symptom Relief/cold and Flu Nighttime Relief",
"Vicks DayQuil Severe Cold and Flu",
"Sinus Daytime",
"Hemorroidal Cooling gel",
"DayQuil Severe plus Vicks VapoCool",
"Sinus Nighttime",
"Cold and Flu",
"Allergy Plus Sinus Headache",
"Mucus Relief PE",
"NyQuil Severe Cold and Flu",
"Pharbinex-PE",
"Sinus and Congestion Relief Daytime",
"Congestion and Cough Childrens",
"Sinus and Allergy",
"Walgreens",
"Severe Congestion and Cough/ Cold and Flu Daytime/nighttime",
"Severe Congestion and Cough/ Cold and Flu Daytime/nighttime",
"Cold and Flu DayTime",
"CVS Health Multi Symptom Severe Cold MULTI SYMPTOM SEVERE COLD",
"Daytime Nighttime Cold Flu Relief",
"Suphedrine PE",
"Multi-Symptom Cold Flu and Sore Throat Maximum Strength",
"Daytime Cold and Flu Nighttime Cold and Flu",
"Daytime Cold and Flu Nighttime Cold and Flu",
"Tylenol Cold Plus Flu Severe",
"Daytime Cold and Flu Non Drowsy",
"Equaline Daytime Cold and Flu Fast Relief Nighttime Cold and Flu Fast Relief",
"Equaline Daytime Cold and Flu Fast Relief Nighttime Cold and Flu Fast Relief",
"Cold and Flu severe",
"Cold and Flu Daytime Relief",
"Mucus Relief Severe Congestion and Sinus",
"Careone Day Cold and Flu Night Cold and Flu",
"Careone Day Cold and Flu Night Cold and Flu",
"Mucus Relief Maximum StrengthCold Flu and Sore Throat",
"MediGummies Allergy and Sinus",
"Tylenol Sinus Severe",
"Basic Care Day Time Cold and Flu Night Time Cold and Flu",
"Basic Care Day Time Cold and Flu Night Time Cold and Flu",
"Multi Symptom Severe Cold",
"Mucus Relief Severe Congestion and Cough Maximum Strength",
"DayTime Nitetime Sinus Relief",
"DayTime Nitetime Sinus Relief",
"Leader Childrens Cold and Allergy",
"Daytime Sinus Relief",
"Vicks DayQuil and Vicks NyQuil Cold and Flu Multi-Symptom Relief/Cold and Flu Nighttime Relief",
"Topcare Day Time Cold and Flu",
"Topcare Nite Time Cold and Flu",
"Daytime Nighttime Severe Cold and Flu",
"Daytime Nighttime Severe Cold and Flu",
"Multi Symptom Severe Cold and Nighttime Severe Cold and Cough",
"Multi Symptom Severe Cold and Nighttime Severe Cold and Cough",
"Severe Cold and Flu",
"Severe Cold and Flu",
"Severe Cold and Flu",
"Nitetime Sinus Relief",
"Welby Day Time Cold and Flu",
"Childrens Cold and Cough",
"Nighttime Severe cold cough and flu relief",
"Childrens Plus Multi Symptom Cold",
"Tussin CF Maximum Strength",
"Sinus and Headache Daytime, Non-Drowsy",
"Mucus Relief MAXIMUM STRENGTH",
"Wal-Phed PE Maximum Strength, Non-Drowsy",
"Vicks DayQuil Severe and Vicks NyQuil Severe Cold and Flu",
"Vicks DayQuil Severe and Vicks NyQuil Severe Cold and Flu",
"Mucus Relief Severe Congestion and Cold Max Maximum Strength",
"4390 First Aid Kit",
"4392 First Aid Kit",
"Severe Congestion and Cough, Cold and Flu Daytime and Nighttime",
"Severe Congestion and Cough, Cold and Flu Daytime and Nighttime",
"Up and Up Nighttime Vapor Ice Cold and Flu",
"Allerfed Cold and Allergy",
"Nighttime Severe Cold and Flu",
"Hemorrhoidal",
"Hemorrhoidal",
"Cold Multi-Symptom Non-Drowsy, Daytime",
"Wal-Phed PE, Multi-Symptom",
"Allergy Multi-Symptom",
"Cold and Head Congestion Severe/Daytime",
"Histex Ac",
"Severe Allergy Plus Sinus Headache",
"Severe Sinus Congestion",
"Maximum Strength Mucinex Fast-Max Night Time Cold and Flu",
"Multi-Symptom Cold Relief",
"Multi-Symptom Cold Relief",
"Severe Congestion and Cough, Cold and Flu Daytime, Nighttime",
"Severe Congestion and Cough, Cold and Flu Daytime, Nighttime",
"Sinus Pressure and Pain Maximum Strength",
"Tukol X-Pecto Miel Multi Symptom Cold",
"DayTime Cold and Flu",
"Cold and Flu Non-Drowsy, DayTime",
"Aphedrid Cold and Allergy",
"Mucus Relief Daytime/Nighttime",
"Mucus Relief Daytime/Nighttime",
"Topcare Mucus Relief",
"Tukol Multi Symptom Cold",
"Maxi-Tuss CD",
"Severe Cold and Flu Daytime",
"Severe Cough and Cold",
"Cold and Flu Relief Daytime",
"Daytime Cold and Flu Non Drowsy",
"Daytime Nighttime Cold Flu Relief",
"Wal-Phed PE Daytime / Nighttime",
"Wal-Phed PE Daytime / Nighttime",
"SUDAFED PE Head Congestion Plus Mucus",
"Leader Flu and Severe Cold and Cough",
"Health Mart Severe Cold Cough and Flu",
"Good Neighbor Pharmacy Flu and Severe Cold and Cough",
"Careone Daytime Severe Cold and Cough",
"Topcare Flu and Severe Cold and Cough Daytime",
"Healthy Accents Severe Cold Daytime",
"Flu and Severe Cold",
"Good Sense Flu and Severe Cold and Cough Daytime",
"Sinus Pressure and Pain",
"TopCare Multi Symptom Severe Cold",
"Equaline Multi Symptom Flu and Severe Cold Daytime",
"Signature Care Daytime Severe Cold",
"Good Sense Multi Symptom Flu and Severe Cold",
"Good Neighbor Pharmacy Flu and Severe Cold and Cough",
"Daytime Nighttime Severe Cold Cough and Flu Relief",
"Daytime Nighttime Severe Cold Cough and Flu Relief",
"Daytime Nighttime Severe Cold",
"Daytime Nighttime Severe Cold",
"Severe Cold, Flu and Cough",
"Severe Cough and Cold",
"Severe Cold and Flu",
"Dg Health Multi Symptom Severe Cold",
"Wal Flu Severe Cold and Cough Daytime Nighttime",
"Wal Flu Severe Cold and Cough Daytime Nighttime",
"Basic Care Daytime Severe Cold and Flu Nighttime Severe Cold, Cough and Flu",
"Basic Care Daytime Severe Cold and Flu Nighttime Severe Cold, Cough and Flu",
"Daytime Severe Cold and Flu Nighttime Severe Cold, Cough and Flu",
"Daytime Severe Cold and Flu Nighttime Severe Cold, Cough and Flu",
"Daytime Nighttime Severe Cold and Flu",
"Daytime Nighttime Severe Cold and Flu",
"Equate Flu and Severe Cold and Cough",
"Severe Cold",
"Leader multi symptom flu and severe cold",
"Flu and Severe Cold",
"Sound Body Severe Cold and Flu",
"Flu and severe cold daytime nighttime",
"Flu and severe cold daytime nighttime",
"Basic Care Severe Cold and Flu",
"Severe Cold and Flu Relief Daytime/Nighttime",
"Severe Cold and Flu Relief Daytime/Nighttime",
"Hemorrhoidal cooling",
"Daytime Cold and Flu Non drowsy",
"CareOne Severe Cold",
"Mucus Relief Maximum Strength",
"Sunmark Cold and Cough DM Childrens",
"Sunmark Chest Congestion Relief PE PE",
"Flu and Severe Cold and Cough Nighttime",
"Health Mart Hemorrhoidal",
"Sinus Pressure and Congestion Relief",
"Sinus Pressure and Congestion Relief",
"Health Mart severe cold cough and flu",
"Good Neighbor Pharmacy Severe Cold",
"Sinus Congestion and Pain Severe",
"Allergy Multi-Symptom",
"Flu and Severe Cold and Cough Nighttime",
"Health Mart Daytime",
"Equate Severe Cold Multi Symptom",
"Equaline Flu and Severe Cold and Cough",
"Flu and Severe Cold and Cough",
"Severe Cold Cough and Flu Relief Nighttime",
"Signature Care severe cold cough and flu Nighttime",
"CareOne Nighttime Severe Cold and Cough",
"Good Sense Flu and Severe Cold and Cough Nighttime",
"Healthy Accents Severe Cold",
"Dg Health Flu and Severe Cold and Cough",
"7 Select Night Time Severe Cold Cough and Flu",
"Up and Up Daytime Vapor Ice Cold and Flu Nighttime Vapor Ice Cold and Flu",
"Up and Up Daytime Vapor Ice Cold and Flu Nighttime Vapor Ice Cold and Flu",
"Flu and Severe Cold and Cough Night Time",
"Topcare Flu and Severe Cold and Cough",
"Cold and Flu Non-Drowsy, Daytime",
"Up and Up Daytime Vapor Ice Cold and Flu Nighttime Vapor Ice Cold and Flu",
"Up and Up Daytime Vapor Ice Cold and Flu Nighttime Vapor Ice Cold and Flu",
"Multi Symptom Cold Childrens Plus",
"Topcare Day Night",
"Topcare Day Night",
"Vicks DayQuil and Vicks NyQuil Cherry Cold and Flu",
"Vicks DayQuil and Vicks NyQuil Cold and Flu",
"Sinus and Allergy Releif PE",
"Vicks DayQuil Severe Cold and Flu",
"Severe cold and flu Nighttime",
"Vicks NyQuil Severe Cold and Flu",
"Vicks DayQuil and Vicks NyQuil Severe Cold and Flu",
"Vicks DayQuil and Vicks NyQuil Severe Cold and Flu",
"Promethazine VC",
"Mucus Relief Sinus Severe Congestion and Pain",
"Sunmark Cold and Allergy Childrens",
"Mucus and Sinus PE",
"Cold Multi-Symptom Nighttime",
"cold and sinus PE",
"Severe Cold",
"cough and sinus PE",
"Mucus Relief All In One Cold and Flu",
"Mucus Relief Sinus Pressure, Pain and Cough",
"Cold and Flu Severe",
"Cold Relief Multi-symptom Daytime",
"Sinus Severe",
"Sinus and Headache",
"Mucus Relief Cold Flu and Sore Throat",
"pressure and pain PE",
"allergy and sinus PE",
"Cold Relief Severe Head Congestion",
"Health Mart Cold and Allergy Childrens",
"Cold and Flu Daytime/Multi-Symptom/Non-Drowsy",
"Daytime Sinus Nighttime Sinus Maximum Strength",
"Daytime Sinus Nighttime Sinus Maximum Strength",
"Cold and Flu Relief Non-Drowsy, DayTime, Multi-Symptom",
"Severe Sinus Congestion and Pain Daytime",
"Mucus Relief Daytime/Nighttime/Maximum Strength",
"Mucus Relief Daytime/Nighttime/Maximum Strength",
"DayTime Cold and Flu Non Drowsy",
"Cold and Flu Severe, Nighttime, Maximum Strength",
"Mucus Relief Maximum Strength Multi Symptom Relief",
"Nighttime Severe Cough and Cold",
"Up and Up maximum Strength fast mucus relief Severe Congestion and Cough",
"Severe Cold and Cough Daytime",
"Quality Choice Severe Cold and Cough Nighttime",
"Dg Health Day Time Severe Cold and Flu Relief",
"7 Select Day Time Relief",
"Acetaminophen 500mg, Dextromethorphan HBr 10mg, Guaifenesin 200mg, Phenylephrine HCl 5mg",
"7 Select Day Time Relief",
"Father Johns Cough Medicine Plus",
"Vicks DayQuil and Vicks NyQuil Severe Cold and Flu",
"Vicks DayQuil and Vicks NyQuil Severe Cold and Flu",
"NyQuil Severe VapoCool",
"Chlorpheniramine Maleate, Phenylephrine Hydrochloride",
"DayQuil Severe VapoCool",
"Childrens Pain Relief Cold and Flu",
"Allergy Plus Sinus Headache",
"Presgen",
"Sinus Relief Daytime, Nighttime, Maximum Strength",
"Sinus Relief Daytime, Nighttime, Maximum Strength",
"Pressure plus Pain PE plus Cough",
"Sine Off Sinus/cold Medicine",
"Topcare Day Time Cold and Flu",
"Tusslin Pediatric",
"Topcare Nite Time Cold and Flu",
"Non-drowsy Day Time",
"G-tron Ped",
"Topcare Childrens Cold and Flu",
"Sinus Headache PE Non- Drowsy Maximum Strength",
"Desgen Pediatric",
"Maximum Strength Mucus Relief Cold,Flu and Sore Throat",
"Mucus Relief Cold Flu Sore Throat Maximum Strength",
"Maximum Strength Mucus Relief Severe Congestion and Cough",
"Daytime Cold and Flu Relief",
"Maximum Strength Mucus Relief Severe Congestion and Cough",
"Chloresin",
"sinus plus allergy PE maximum strength",
"Tukol Cough And Cold Honey Flavor",
"Multi-Symptom Cold Daytime",
"Tusslin",
"Childrens Cold and Flu",
"Multi-Symptom Cold and Sinus Maximum Strength",
"Daytime Nighttime Cold Flu Relief",
"Equate Tussin CF",
"Childrens Allergy Plus Congestion Relief",
"Rugby Hemorrhoidal",
"Maximum Strength Mucinex Fast-Max Cold and Flu",
"Suphedrine PE Sinus plus Allergy",
"Anu-Med",
"Day Time Severe Cold and Cough",
"DayTime Nighttime multi symptom cold and flu relief",
"Multi Symptom Cold CF Adult",
"Night Time Severe Cold and Cough",
"Equate Daytime Cold and Flu",
"Day Time with PE",
"Childrens Plus Multi-Symptom Cold Grape with PE",
"Severe Cold and Cough Nighttime",
"Tussin CF",
"Severe Cold and Cough Daytime",
"Wal-Phed PE Multi Symptom",
"Flu Relief Therapy Day Time",
"Cold and Flu Relief Daytime, Multi-Symptom",
"Sinus and Headache Daytime, Non-Drowsy",
"Nighttime Wal Flu Severe Cold and Cough",
"Multi Symptom Severe Cold and Nighttime Severe Cold and Cough",
"Multi Symptom Severe Cold and Nighttime Severe Cold and Cough",
"Multi Symptom Wal Flu Severe Cold",
"Cold Relief Multi-Symptom Severe",
"Severe cold and cough relief",
"Cold Relief Cold and Flu Severe",
"childrens Multi Symptom Fever and Cold",
"Sinus Relief Congestion and Pain Severe",
"Cold Terminator Max",
"Mucus Relief Cold Flu and Sore Throat",
"Severe Cold and Cough Relief Nighttime",
"Severe Congestion and Pain",
"Cold Relief Head Congestion Severe",
"Cold Relief Multi-Symptom Daytime",
"Broncolin Cold and Flu Relief",
"Severe Congestion and Cold Maximum Strength/ Multi-Symptom",
"Allergy Plus Sinus Headache",
"Daytime Nighttime Cold and Flu Relief Multi-Symptom",
"Severe Cold and Mucus",
"Childrens Cold and Allergy",
"Daytime Nighttime Cold and Flu Relief Multi-Symptom",
"Cold and Flu Relief Multi symptom",
"Equate Nighttime Cold and Flu",
"Cold and Flu Relief DayTime",
"Night Time Cold and Cough Childrens",
"Cold MULTI-SYMPTOM, DAYTIME / NIGHTTIME",
"Cold MULTI-SYMPTOM, DAYTIME / NIGHTTIME",
"Nighttime Cold Max",
"Sinus and Allergy PE",
"Cold and Flu Relief Multi symptom",
"TheraFlu Cold and Flu",
"Cold Head Congestion Severe",
"Cold and Flu DayTime",
"Tussin CF Non Drowsy Multi Symptom",
"Childrens Cold and Cough",
"Daytime Nighttime Cold Flu Relief",
"Daytime Nighttime Cold and Flu Relief Multi-Symptom",
"Tussin Multi Symptom Cold CF Adult",
"Nighttime Sinus Multi symptom",
"Cold Max",
"Mucus Relief Severe Congestion and Cough Maximum Strength",
"Cold and Allergy Relief",
"Tussin CF Non Drowsy Multi Symptom",
"Theraflu Expressmax Daytime Severe Cold and Cough and Theraflu Expressmax Nighttime Severe Cold and Cough",
"Theraflu Expressmax Daytime Severe Cold and Cough and Theraflu Expressmax Nighttime Severe Cold and Cough",
"Childrens Plus Multi Symptom Cold",
"Daytime sinus Non Drowsy",
"Daytime Cold and Flu",
"DayTime Multi-Symptom",
"Mucus Relief Cold, Flu, Sore Throat Maximum Strength",
"Cold and Flu Relief Multi symptom",
"Sinus Severe",
"Daytime Cold and Flu",
"Mucus Relief DM MAX Maximum Strength",
"Cold Multi-Symptom",
"Childrens Day Time Cold and Cough",
"Severe Cold, Cold and Flu Maximum Strength, Daytime, Nightime",
"Severe Cold, Cold and Flu Maximum Strength, Daytime, Nightime",
"Sinus Headache Day Night",
"Sinus Headache Day Night",
"Cold and Congestion Childrens Nighttime",
"Severe Cold",
"Severe Sinus Congestion and Pain",
"Childrens Plus Multi Symptom Cold",
"Daytime Cold and Flu Relief",
"Cough Cold and Sore Throat Childrens",
"Mucus Relief Cold Flu and Sore Throat Maximum Strength",
"Cough and Cold Nighttime",
"Severe Sinus Congestion and Pain Daytime",
"Childrens Allergy Plus Congestion",
"Cold and Flu Daytime, Nighttime",
"Cold and Flu Daytime, Nighttime",
"Childrens Wal Tap Elixer Cold and Allergy",
"Wal-Phed PE Maximum Strength",
"Cold and Head Congestion Severe",
"Multi-Symptom Cold Daytime",
"Mucus Congestion and Cough Relief Childrens",
"Sinus Congestion and Pain Relief Non-Drowsy/Daytime",
"Daytime Nighttime Cold and Cough Childrens",
"Daytime Nighttime Cold and Cough Childrens",
"Pressure and Pain PE",
"Cold Flu Severe Day Night",
"Cold Flu Severe Day Night",
"Severe Cold Multi Symptom",
"Mucus Relief Sinus Day and Night",
"Mucus Relief Sinus Day and Night",
"Sinus Relief MAXIMUM STRENGTH",
"Cold Allergy",
"Family Wellness Multi Symptom Severe Cold",
"Sinus Pressure and Pain Maximum Strength",
"Cold Flu Severe",
"Severe Cold and Flu Maximum Strength, Daytime, Non-Drowsy",
"Allergy Multi Symptom",
"Complete Allergy and Sinus Multi Symptom",
"Cold Head Congestion Severe",
"Daytime Severe Cold and Flu Maximum Strength",
"Topcare Mucus Relief Cold and Flu",
"Cold Multi Symptom Nighttime",
"Cold Multi-Symptom Nighttime",
"Severe Cold Head Congestion",
"Severe Congestion and Sinus Relief Maximum Strength",
"Mucus Relief Cold and Sinus Maximum Strength",
"Mucus Relief Cold Flu and Sore Throat Maximum Strength",
"Mucus Relief Severe Cold",
"Mucus Relief Nighttime Congestion Cough Maximum Strength",
"Mucus Relief Cold Flu and Sore Throat Maximum Strength",
"Cold Head Congestion Nighttime",
"Sinus and Headache Daytime",
"Mucus Relief Severe Cold",
"Pressure and Pain and Cold",
"Allergy Plus Sinus Headache",
"Mucus Relief Cold and Sinus",
"Mucus Relief Cold Flu and Sore Throat",
"Mucus Relief Maximum StrengthCold Flu and Sore Throat",
"Cold Multi Symptom Daytime Nighttime",
"Cold Multi Symptom Daytime Nighttime",
"Mucus Relief Cold Flu Sore Throat Maximum Strength",
"Mucus Relief Cold, Flu and Sore Throat",
"Severe Allergy Plus Sinus Headache",
"Sinus plus Headache Daytime and Nighttime",
"Sinus plus Headache Daytime and Nighttime",
"Mucus Relief Sinus Severe Congestion Relief",
"Cold Multi-Symptom Daytime and Nighttime",
"Cold Multi-Symptom Daytime and Nighttime",
"Mucus Relief PE",
"Wal-Phed PE, Multi-Symptom, Daytime, Nighttime",
"Wal-Phed PE, Multi-Symptom, Daytime, Nighttime",
"Mucus Sinus Relief Day and Night",
"Mucus Sinus Relief Day and Night",
"Mucus Relief Sinus Pressure and Pain",
"Cold Flu and Sore Throat",
"Sinus Severe",
"Cold and Flu",
"Severe Congestion and Cough, Cold and Flu Daytime, Nighttime",
"Severe Congestion and Cough, Cold and Flu Daytime, Nighttime",
"Cold Multi-Symptom Severe",
"Pressure Pain Mucus",
"Severe Congestion",
"Pressure Pain Cold",
"Pressure Pain",
"Cold Flu Severe",
"Mucinex Fast-Max Congestion and Headache",
"Severe Cold and Flu",
"Cold Head Congestion Severe",
"Mucinex Sinus-Max Severe Congestion and Pain",
"Sinus Congestion and Pain Relief",
"Histenol Forte II",
"Cold Max",
"Sinus Severe",
"Acetaminophen, Phenylephrine Hydrochloride",
"Maximum Strength Mucinex Fast-Max Day Cold and Flu and Night Cold and Flu",
"Maximum Strength Mucinex Fast-Max Day Cold and Flu and Night Cold and Flu",
"Daytime Mucus Relief Severe Congestion and Cough and Nighttime Cold and Flu Maximum Strength",
"Daytime Mucus Relief Severe Congestion and Cough and Nighttime Cold and Flu Maximum Strength",
"Cold Max",
"Daytime Mucus Relief Severe Cold Nighttime Cold and Flu Maximum Strength",
"Daytime Mucus Relief Severe Cold Nighttime Cold and Flu Maximum Strength",
"Sinus Headache",
"Pressure Pain Cold",
"Acetaminophen, Chlorpheniramine Maleate, Phenylephrine Hydrochloride",
"Cold Flu Sore Throat",
"Family Wellness Severe Cold and Cough",
"Sinus Relief Severe Congestion Maximum Strength",
"Mucus Relief Severe Cold Daytime Maximum Strength",
"Flu Relief Therapy Nighttime",
"Sinus Relief PE Maximum Strength",
"Mucinex Fast-Max Cold, Flu and Sore Throat",
"Severe Cold",
"Sinus Relief Maximum Strength",
"Multi-Symptom Cold Relief Daytime",
"Acetaminophen, Dextromethorphan Hydrobromide, Guaifenesin, Phenylephrine Hydrochloride",
"Severe Cold and Flu Relief Daytime/Nighttime",
"Severe Cold and Flu Relief Daytime/Nighttime",
"Mucinex Sinus - Max Day / Night",
"Mucinex Sinus - Max Day / Night",
"Daytime Mucus Relief Severe Cold Nighttime Cold and Flu Maximum Strength",
"Daytime Mucus Relief Severe Cold Nighttime Cold and Flu Maximum Strength",
"Daytime Nighttime Sinus Relief Maximum Strength",
"Daytime Nighttime Sinus Relief Maximum Strength",
"Sinus Severe",
"Cold Flu Severe",
"Severe Cold and Cough Daytime",
"Cold Multi-Symptom Daytime",
"Equate Nighttime Vapor Ice Cold and Flu",
"Sinus Relief Congestion and Cough Maximum Strength",
"Flu Relief Childrens",
"Pressure Pain PE",
"Equate Daytime Vapor Ice Cold and Flu",
"Allergy Multi-Symptom",
"Cold Head Congestion Severe",
"Cold Sinus",
"Cold Flu Severe Day Night",
"Cold Flu Severe Day Night",
"DayTime Mucus Relief Severe Cold and Nighttime Cold and Flu Maximum Strength",
"DayTime Mucus Relief Severe Cold and Nighttime Cold and Flu Maximum Strength",
"ColdaeWon Nose A",
"Cold and Allergy",
"Nighttime Cold and Flu Maximum Strength",
"Advil Sinus Congestion and Pain",
"Daytime Liquid Caps",
"Mucus Relief Cold Flu and Sore Throat Maximum Strength",
"Sinus Pressure Pain Maximum Strength, Non-Drowsy",
"Topcare Day Time Nite Time Cold and Flu",
"Topcare Day Time Nite Time Cold and Flu",
"Cold Multi-Symptom Daytime Nighttime",
"Cold Multi-Symptom Daytime Nighttime",
"Sinus and Allergy",
"Sinus PE Pressure plus Pain MAXIMUM STRENGTH",
"Mucus Relief Cold and Sinus Maximum Strength",
"Mucus Relief Severe Congestion and Cough Maximum Strength",
"Basic Care Hemorrhoidal",
"Daytime Cold and Cough and NightTime Cold and Congestion Childrens",
"Daytime Cold and Cough and NightTime Cold and Congestion Childrens",
"Fast Mucus Relief Cold Flu and Sore Throat Maximum Strength Multi-Symptom",
"Daytime Mucus Relief Severe Cold Nighttime Cold and Flu Maximum Strength",
"Daytime Mucus Relief Severe Cold Nighttime Cold and Flu Maximum Strength",
"Cold Max Daytime",
"DayTime Mucus Relief Severe Cold and Nighttime Cold and Flu Maximum Strength",
"DayTime Mucus Relief Severe Cold and Nighttime Cold and Flu Maximum Strength",
"Allergy Multi-Symptom",
"Nighttime Cold and Flu Maximum Strength",
"Pressure Plus Pain PE Plus Mucus",
"Cold Plus Head Congestion Nighttime",
"Mucus Relief Congestion and Cough Maximum Strength",
"Cold Plus Head Congestion Daytime",
"Mucus Relief Severe Cold Daytime Maximum Strength",
"Sinus Plus Headache Day and Night",
"Sinus Plus Headache Day and Night",
"Pressure Plus Pain PE Plus Cough",
"Pressure and Pain PE",
"Mucus Relief Cold, Flu and Sore Throat",
"Severe Cold PE",
"Pressure Plus Pain PE Plus Cold",
"Allergy Multi Symptom",
"Family Wellness Hemorrhoidal",
"Cold and Head Congestion Severe",
"Cold Plus Head Congestion Day and Night",
"Cold Plus Head Congestion Day and Night",
"Cold Max Nighttime",
"Mucus Relief Severe Cold Daytime Cold and Flu Nighttime",
"Mucus Relief Severe Cold Daytime Cold and Flu Nighttime",
"Sinus Relief Day and Night",
"Sinus Relief Day and Night",
"Equate Daytime Cold and Flu",
"Childrens Cold and Allergy",
"Flu Relief Therapy Nighttime Severe Cold",
"Cold Max Severe",
"Day Time Cold and Flu",
"Childrens Dibromm Cold and Allergy",
"Childrens Plus Multi Symptom Cold",
"Sinus Headache",
"Cold Max Day and Night",
"Cold Max Day and Night",
"Cold Flu Severe",
"Childrens Plus Multi Symptom Cold",
"Multi-Symptom Cold Severe, Non-Drowsy, Daytime",
"Allergy Plus Sinus Headache",
"Flu and Sore Throat",
"Delsym Cough Plus Cold Night Time",
"Allergy Multi Symptom",
"Advil Allergy and Congestion Relief",
"Advil Allergy and Congestion Relief",
"Cold and Allergy",
"Cold Head Congestion",
"Day Time Cold and Flu non drowsy",
"Delsym Cough Plus Chest Congestion DM and Delsym Cough Plus Cold Night Time",
"Tussin Multi Symptom Cold CF Adult",
"Cold and Flu Nighttime",
"Daytime Cold and Flu multi symptom",
"Daytime Severe Cold and Flu",
"Childrens Cold and Allergy Relief",
"Cold and Flu Relief Multi-Symptom, Day, Night",
"Daytime Nighttime Cold and Flu",
"Multi-Symptom Cold",
"Multi Symptom Cold Relief CF Non Drowsy",
"Severe Cold Daytime Multi-Symptom Non-Drowsy",
"Cold and Flu DayTime",
"Daytime Mucus Relief Severe Cold and Nighttime Cold and Flu Maximum Strength",
"Daytime Mucus Relief Severe Cold and Nighttime Cold and Flu Maximum Strength",
"Severe Cold, Cold and Flu Daytime, Nighttime, Maximum Strength",
"Severe Cold, Cold and Flu Daytime, Nighttime, Maximum Strength",
"Daytime Non Drowsy",
"Daytime Cold and Flu Relief Non Drowsy",
"Daytime Nighttime Cold Flu Relief",
"Flu and Sore Throat",
"Sinus PE Pressure, Pain and Cold Daytime, Non-Drowsy",
"Physicians Care Cold Cough",
"Cold Flu and Sore Throat Maximum Strength",
"Health Mart Severe Cold and Flu",
"Flu and Severe Cold Daytime Relief",
"Tussin CF Maximum Strength",
"Daytime Nighttime Sinus Relief Maximum Strength",
"Daytime Nighttime Sinus Relief Maximum Strength",
"Health Mart Childrens Cold and Flu",
"Severe Cold and Flu",
"Daytime Cold and Flu Relief Non Drowsy",
"Daytime Mucus Relief Severe Cold and Nighttime Cold and Flu Maximum Strength",
"Daytime Mucus Relief Severe Cold and Nighttime Cold and Flu Maximum Strength",
"Cold Relief Multi Symptom Severe",
"Cold Relief Multi-Symptom, Daytime, Nighttime, Non-drowsy",
"Cold Relief Multi-Symptom, Daytime, Nighttime, Non-drowsy",
"DayTime NightTime Cold/Flu",
"DayTime NightTime Cold/Flu",
"Flu and Severe Cold Nighttime Relief",
"Daytime Cold and Flu Relief Multi-Symptom",
"DS Never Cold S",
"Cold and Flu Relief Daytime",
"Mucus Relief Cold and SInus Max Maximum Strength",
"Daytime Nighttime Cold Flu Relief",
"Cold and Allergy",
"Multi-Symptom Cold and Flu DayTime",
"Daytime Nighttime Cold Flu Relief",
"Multi-Symptom Cold and Flu DayTime",
"Cold, Flu and Sore Throat Relief Maximum Strength, Multi Symptom",
"Childrens Plus Multi Symptom Cold",
"Walgreens Severe Warming Cold and Flu For Adults",
"Mucus Relief Cold Flu and Sore Throat Maximum Strength",
"Daytime Severe Cold and Flu Relief Softgels",
"AuroMucus - Fast Maximum Cold, Flu and Sore Throat Relief",
"KMart - Fast Maximum Cold, Flu and Sore Throat Relief",
"Triacting Day Time Cold and Cough Childrens",
"Walgreens Severe Cold Multi-Symptom For Adults",
"AuroMucus - Childrens Multi-Symptom Cold",
"Severe Nighttime Cold and Flu",
"Daytime Cold and Flu Non Drowsy",
"AuroMucus - Childrens Stuffy Nose and Cold",
"Night Time Cold Max",
"AuroMucus - Fast Maximum Cold and Sinus",
"AuroMucus Fast Maximum Night Time Cold and Flu",
"AuroMucus - Childrens Stuffy Nose and Cold",
"AuroMucus - Fast Maximum Severe Congestion and Cough",
"AuroFlu Day Time Severe Cold and Cough Warming Relief",
"Severe Cold and Flu Daytime Non Drowsy Nighttime",
"Severe Cold and Flu Daytime Non Drowsy Nighttime",
"Multi Symptom Cold and Multi Symptom Nighttime Cold Childrens",
"Multi Symptom Cold and Multi Symptom Nighttime Cold Childrens",
"Daytime Nighttime Cold Flu Relief",
"Suphedrine PE Pressure plus Pain Maximum Strength, Non-Drowsy",
"AuroFlu Night Time Severe Cold and Cough Warming Relief",
"KMart - Fast Maximum Cold and Sinus",
"KMart - Fast Maximum Severe Congestion and Cough",
"Walgreens Daytime non-drowsy cold multi-symptom for adults",
"Mucus Relief Maximum Strength Severe Congestion and Cough",
"AuroFlu Flu and Sore Throat Warming Relief",
"Daytime Nighttime Cold Flu Relief",
"Multi Symptom NightTime Cold",
"Severe Cold and Mucus",
"Flu, Cough and Sore Throat",
"Childrens Daytime Cold and Cough",
"DayTime Severe Congestion Relief and Nighttime Severe Cough and Congestion Relief Maximum Strength",
"DayTime Severe Congestion Relief and Nighttime Severe Cough and Congestion Relief Maximum Strength",
"Mucus Relief Plus",
"Severe Allergy And Sinus Headache Maximum Strength",
"Daytime Cold and Flu Multi symptom relief",
"NightTime Relief Severe Cold and Flu",
"Mucus Relief Severe Congestion and Cough Maximum Strength",
"Aurotussin Peak Cold Maximum Strength Multi-Symptom Cold",
"Suphedrine PE",
"Mucus Relief Cold Flu Sore Throat",
"Auromine Childrens Cold and Allergy",
"Sinus Relief Severe Congestion Maximum Strength",
"Multi Symptom Cold CF",
"Aurophen Cold Multi Symptom",
"Daytime Mucus Relief Severe Congestion and Cough and Nighttime Cold and Flu Maximum Strength",
"Daytime Mucus Relief Severe Congestion and Cough and Nighttime Cold and Flu Maximum Strength",
"Aurophen Cold Multi-Symptom Severe",
"Sinus Relief Congestion and Cough Maximum Strength",
"Childrens Stuffy Nose and Cold",
"Daytime Relief Severe Cold and Flu",
"Walgreens Daytime Non-Drowsy Cold and Flu",
"Walgreens Daytime Non-Drowsy Cold and Flu",
"Aurophen Cold Multi Symptom",
"Cold and Flu Nighttime",
"Childrens Aurotussin Cough and Cold CF",
"Aurophen Cold and Flu Severe",
"Multi Symptom Cold Double Max Power",
"Severe Cold Daytime",
"Maximum Strength Mucinex Sinus-Max Severe Congestion and Pain",
"Childrens Daytime Cold and Cough",
"Vanacof DM",
"Mucus Relief All In One Daytime Nighttime Cold Flu Maximum Strength",
"Mucus Relief All In One Daytime Nighttime Cold Flu Maximum Strength",
"Presgen B",
"Nasal Decongestant PE and Pain Relief Plus Mucus Relief",
"Aurotussin Peak Cold Multi-Symptom Cold",
"Sinus Congestion PE",
"Nasopen PE",
"Alka-Seltzer Plus Maximum Strength Severe Sinus, Allergy and Cough",
"Alka-Seltzer Plus Maximum Strength Severe Sinus Congestion and Cough Day and Night",
"Alka-Seltzer Plus Maximum Strength Severe Sinus Congestion and Cough Day and Night",
"Childrens Cold and Allergy",
"Alka-Seltzer Plus Maximum Strength Day Cold and Flu",
"Alka-Seltzer Plus Maximum Strength Day and Night Cold and Flu",
"Alka-Seltzer Plus Maximum Strength Day and Night Cold and Flu",
"Alka-Seltzer Plus Maximum Strength Night Cold and Flu",
"Alka-Seltzer Plus Maximum Strength Night Cold and Flu PowerMax Gels",
"Alka-Seltzer Plus Cold Medicine Sparkling Original",
"Handy Solutions Cold Relief",
"DayTime Cold Flu Non Drowsy",
"Alka-Seltzer Plus Maximum Strength Day and Night Cold and Flu PowerMax Gels",
"Alka-Seltzer Plus Maximum Strength Day and Night Cold and Flu PowerMax Gels",
"DayTime Cold Flu Non Drowsy",
"Alka-Seltzer Plus Maximum Strength Day and Night Cold and Flu",
"Alka-Seltzer Plus Maximum Strength Day and Night Cold and Flu",
"Alka-Seltzer Plus Maximum Strength Cold and Cough",
"Alka-Seltzer Plus Maximum Strength Day and Night Cold and Flu PowerMax Gels",
"Alka-Seltzer Plus Maximum Strength Day and Night Cold and Flu PowerMax Gels",
"Alka-Seltzer Plus Multi-Symptom Cold and Flu Day and Night Liquid Gels",
"Alka-Seltzer Plus Multi-Symptom Cold and Flu Day and Night Liquid Gels",
"Alka-Seltzer Plus Severe Cough Mucus and Congestion Day and Night",
"Alka-Seltzer Plus Severe Cough Mucus and Congestion Day and Night",
"Multi Symptom Sinus Relief Pain and Congestion Daytime Nighttime",
"Multi Symptom Sinus Relief Pain and Congestion Daytime Nighttime",
"Alka-Seltzer Plus Maximum Strength Day Cold and Flu PowerMax Gels",
"Wal-Dryl Maximum Strength",
"Alka-Seltzer Plus Severe Cough Mucus and Congestion Liquid Gels",
"Severe Cold and Flu nighttime",
"Alka-Seltzer Plus Severe Sinus Cold and Cough Liquid Gels",
"Antiflu",
"Tussi Pres B",
"Nighttime Flu Relief Therapy Severe Cold",
"Severe Cold and Cough Relief Daytime",
"Mucus Relief Cold, Flu, and Sore Throat Maximum Strength",
"Cold and Flu Severe, Day and Nighttime",
"Cold and Flu Severe, Day and Nighttime",
"Mucus Relief Congestion and Cough Maximum Strength",
"Mucus Relief Daytime Severe Cold Nighttime Cold and Flu Maximum Strength",
"Mucus Relief Daytime Severe Cold Nighttime Cold and Flu Maximum Strength",
"Maximum Strength Mucinex Fast-Max Cold and Flu",
"Rescon GG",
"Tussin Multi Symptom Cold CF",
"Physicians Care Allergy Plus",
"Daytime Nighttime Cold and Flu Relief Multi-Symptom",
"DayTime Sinus Relief",
"Night Cold Flu Cough and Allergy",
"Wal-Dryl PE ALLERGY PLUS CONGESTION",
"Medique Medicidin D",
"Otis Clapp Valihist",
"NightTime Sinus Relief",
"PhysiciansCare Allergy Multi-Symptom Relief",
"Cold Flu Relief Daytime",
"DayTime Sinus",
"Nighttime Cold and Flu Relief Therapy",
"Tussin CF Non Drowsy",
"Cough and Cold plus",
"Dibromm Cold and Allergy Childrens",
"Sinus Relief Daytime, Nighttime",
"Sinus Relief Daytime, Nighttime",
"NightTime Sinus",
"Cold and Allergy Maximum Strength",
"Daytime Non Drowsy",
"Sinus and Allergy Relief PE",
"Cold and Cough Childrens",
"Childrens Triacting Nighttime Cold and Cough",
"Mucus Relief Cold Flu and Sore Throat Maximum Strength",
"Mucus Relief Cold and Sinus Maximum Strength",
"Daytime Cold and Flu Non Drowsy",
"DayTime Cold and Flu",
"Mucus Relief Cold Flu and Sore Throat Maximum Strength",
"Mucus Relief Severe Congestion and Cough Maximum Strength",
"Mucus Relief Severe Congestion and Cough Maximum Strength",
"Cold and Flu Relief Daytime",
"Daytime Nighttime Cold Flu Relief Multi Symptom",
"Topcare Day Time Nite Time Cold and Flu",
"Topcare Day Time Nite Time Cold and Flu",
"Basic Care Daytime Nighttime Severe Cold and Flu",
"Basic Care Daytime Nighttime Severe Cold and Flu",
"Cyclomydril",
"Day Time Cold and Flu Severe",
"Daytime Nighttime Sinus Relief Maximum Strength",
"Daytime Nighttime Sinus Relief Maximum Strength",
"DayTime Cold and Flu Severe and NightTime Cold and Flu Severe",
"DayTime Cold and Flu Severe and NightTime Cold and Flu Severe",
"Leader Severe Cold and Cough",
"Childrens Coltalin",
"Leader Tussin",
"Night Time Cold and Flu Severe",
"Day and Night Severe Sinus Congestion and Cough Maximum Strength",
"Day and Night Severe Sinus Congestion and Cough Maximum Strength",
"Xpecto soothing relief",
"Norel AD",
"NoHist LQ",
"Desgen DM",
"Gencontuss",
"NoHist DM",
"EndaCof DM",
"LoHist DM",
"G-tusicof",
"Tusicof",
"G-tron Pediatric Drops",
"Healthy Accents Tussin CF",
"Daytime Cold and Flu",
"Dometuss-DA",
"Mucinex Sinus-Max Day Night",
"Mucinex Sinus-Max Day Night",
"Dometuss-dmx",
"Sound Body Cold and Flu Relief",
"Dometuss-NR",
"Sound Body Cold and Flu Relief DayTime",
"Childrens Plus Multi Symptom Cold",
"Childrens Cold and Cough Nighttime",
"Daytime Cold and Flu Multi symptom relief",
"Multi Symptom Severe Cold",
"Daytime Severe Cold Nighttime Cold and Flu",
"Daytime Severe Cold Nighttime Cold and Flu",
"Childrens Cold and Cough Relief",
"Sinus Pain and Congestion",
"Severe Tussin CF",
"Circle K Daytime Cold and Flu",
"Circle K Daytime Cold and Flu",
"Circle K Daytime Cold and Flu",
"Circle K Daytime Cold and Flu",
"Circle K Daytime Cold and Flu",
"Day and Night Sinus Relief Maximum Strength",
"Day and Night Sinus Relief Maximum Strength",
"Rycontuss Cherry Flavor",
"COLD FLU and SORE THROAT RELIEF",
"DG Day Time Cold and Flu Formula and Night Time Cold and Flu Formula",
"DG Day Time Cold and Flu Formula and Night Time Cold and Flu Formula",
"Tussin Multi Symptom Cold CF Adult",
"DayQuil Severe",
"Cold and Flu Relief Daytime",
"Severe sinus Congestion Relief",
"Day Time Cold and Flu non drowsy",
"Severe Sinus Congestion Allergy and Cough Formula",
"Non-Drowsy Sinus Daytime",
"CVS Daytime COLD and FLU RELIEF and Nighttime COLD and FLU RELIEF",
"CVS Daytime COLD and FLU RELIEF and Nighttime COLD and FLU RELIEF",
"Night Time Severe Cold and Flu Relief",
"Daytime Cold and Flu Non drowsy",
"Tussin CF Adult Multi Symptom Cold",
"Leader Nighttime Severe Cold and Flu",
"Pain and Sinus Reliever",
"Cold Relief Maximum Strength / Day Time",
"Daytime Cold and Flu and Nighttime Cold and Flu",
"Daytime Cold and Flu and Nighttime Cold and Flu",
"DAY Cold and Flu Plus and NIGHTTIME Cold and Flu Plus",
"DAY Cold and Flu Plus and NIGHTTIME Cold and Flu Plus",
"Day and Night Cold and Flu Formula",
"Day and Night Cold and Flu Formula",
"Daytime Severe Cold Multi-symptom",
"Severe sinus Congestion Relief",
"Cold, Flu and Sore Throat",
"Daytime Congestion Pressure and Pain",
"Handy Solutions Sinus Congestion and Pain Relief",
"COLD FLU and SORE THROAT RELIEF",
"Cold and Flu Severe",
"Daytime Severe Cold and Flu Relief",
"Nighttime Cold and Flu",
"Sever Daytime Cold and Flu and Sever Nighttime Cold and Flu",
"Sever Daytime Cold and Flu and Sever Nighttime Cold and Flu",
"Equate Daytime",
"Sinus Pressure and Pain Daytime Nighttime Maximum Strength",
"Sinus Pressure and Pain Daytime Nighttime Maximum Strength",
"Equate Daytime Severe",
"Equate Day time cold and flu multi symptom relief",
"Cold and Flu Relief Severe Daytime",
"Daytime Nitetime",
"Daytime Severe Cold And Cough",
"Allergy Multi-Symptom",
"Mucus Relief Sinus",
"allergy sinus PE",
"Maximum Strength Night Time Cold and Flu Relief",
"Multi-Symptom Severe Cold",
"Severe Cold and Flu",
"Cold and Sore Throat",
"Mucinex Fast-Max SEVERE COLD",
"Severe Cold",
"Cold Relief Multi Symptom",
"Daytime",
"Alka-Seltzer Plus Cold Orange Zest",
"Fast Mucus Relief",
"Good Neighbor Pharmacy Cold and Cough",
"Alka-Seltzer Plus Severe Cold and Flu",
"Severe Sinus Congestion and Pain Non-Drowsy, Daytime",
"Daytime Severe Cold and Flu",
"Good Neighbor Pharmacy Tussin CF",
"Nighttime Cold and Cough Childrens",
"Sinus Relief",
"Sinus Relief",
"Good Neighbor Pharmacy Day Time",
"Circle K Multi-Symptom Sinus Relief",
"Circle K Cold",
"Good Neighbor Pharmacy Mucus Relief cold and sinus",
"Good neighbor pharmacy mucus relief",
"Multi-Symptom Mapap Cold Formula",
"Childrens Cough and Cold Nighttime",
"Allergy Multi Symptom",
"Alka-Seltzer Plus Cold Night",
"Fast Mucus Relief",
"Fast Mucus Relief",
"Sinus Congestion and Pain Day, Non-Drowsy",
"Good Neighbor Pharmacy Congestion Relief",
"Alka-Seltzer Plus Cold and Cough",
"DayTime NiteTime Severe",
"DayTime NiteTime Severe",
"Allergy Relief",
"Good Neighbor Pharmacy Day Time Cold and Flu",
"Cold and Flu Relief Multi-Symptom, DayTime",
"Sinus Congestion and Pain Daytime",
"Good Neighbor Pharmacy Severe Day Time",
"Cold Multi Symptom",
"Sinus Relief",
"Night Time Day Time",
"Daytime Cold and Flu Non Drowsy",
"Sinus Relief",
"Daytime Cold and Flu Non Drowsy",
"Daytime Nighttime Cold Flu Relief",
"Texaclear Congestion and Pain Sinus Relief",
"Primary Health - Fast Maximum Cold, Flu and Sore Throat Relief",
"COLD and FLU Day Time Multi-Symptom Relief",
"Day Time COLD and FLU non-drowsy",
"Childrens Cold, Cough and Sore Throat",
"Daytime Severe Cold and Cough",
"Auro Mucus - Childrens Cold, Cough and Sore Throat",
"AuroMucus - Fast Maximum Severe Congestion and Cough",
"AuroQuil COLD and FLU Day Time Multi-Symptom Relief",
"Adult tussin Peak Cold Multi-Symptom Cold",
"AuroQuil Severe Cold and Flu Nighttime Relief",
"Night Time Severe Cold and Cough",
"Childrens Cold and Allergy",
"Adult Tussin CF Multi-Symptom Cold",
"AuroQuil Severe Cold and Flu Daytime Relief",
"Cold and Flu Relief Multi-Symptom",
"COLD and FLU Day Time Multi-Symptom Relief",
"Fast Acting Cold, Flu and Sore Throat Relief",
"Auroflu Day Time Severe Cold and Cough",
"Topcare Day Time Cold and Flu Relief Multi Symptom Relief",
"CVS - Childrens Stuffy Nose and Cold",
"Mucinex Fast-Max Severe Cold",
"Topcare Sinus Congestion and Pain",
"Good Neighbor Pharmacy Severe Night Time",
"CVS - Childrens Mucus Relief Cough, Cold and Sore Throat",
"Good Neighbor Pharmacy Sinus Relief",
"Childrens Cold and Allergy",
"Childrens Daytime Cold and Cough",
"Topcare Day Time Cold and Flu Severe",
"Topcare Sinus Relief",
"Topcare Tussin CF Max",
"Topcare Childrens Triacting Nightime Cold and Cough",
"Good Neighbor Pharmacy Sinus Relief",
"AuroFlu Night Time Severe Cold and Cough",
"Mucus Relief Maximum StrengthCold Flu and Sore Throat",
"Childrens Cough and Cold CF",
"good neighbor pharmacy tussin CF Max",
"NiteTime Sinus",
"Sinus Pain and Congestion",
"Sinus Pain and Congestion",
"Daytime Nighttime Cold Flu Relief",
"Good Neighbor Pharmacy Mucus Relief Severe Cold Cold and Flu Night Time",
"Good Neighbor Pharmacy Mucus Relief Severe Cold Cold and Flu Night Time",
"DayTime Cold and Flu Non Drowsy",
"Good Neighbor Pharmacy Mucus Relief Severe Cold",
"Topcare Allergy Multi Symptom",
"Good Neighbor Pharmacy Sinus Relief Day Time Night Time",
"Good Neighbor Pharmacy Sinus Relief Day Time Night Time",
"Topcare Mucus Relief cold and sinus",
"Good Neighbor Pharmacy Childrens Mucus Relief",
"Topcare Tussin CF",
"Cold Relief Multi-Symptom",
"Daytime Cold and Flu",
"Mucus Relief Congestion and Headache Maximum Strength",
"Topcare Day Time Nite Time Cold and Flu",
"Topcare Day Time Nite Time Cold and Flu",
"Good Neighbor Pharmacy Cold and Flu Night Time",
"Mucus Relief Cold and Sinus Maximum Strength",
"Walprofen Congestion Relief and Pain",
"Topcare sinus relief pressure and pain",
"Daytime Nighttime Cold and Flu Relief Multi-Symptom",
"Topcare Nite Time Cold and Flu",
"Good Neighbor Pharmacy Day Time Severe",
"Topco tussin cf max",
"Fast Maximum Night Time Cold and Flu",
"Severe Cold and Flu",
"Cold Max Nighttime",
"Hemorrhoidal Relief",
"Tukol Cough and Congestion",
"Topcare Cold and Flu",
"Topcare Cold and Flu",
"Daytime Cold and Flu",
"Dibromm Cold and Cough Childrens",
"Daytime Nighttime Cold and Flu",
"Childrens Mucus Relief Multi Symptom Cold",
"Daytime Severe Cold and Flu Relief",
"Fast Maximum Severe Congestion and Cough",
"tussin severe multi symptom cough cold plus flu CF MAX",
"Severe Cold and Flu Relief Nighttime",
"Childrens Plus Multi-Symptom Cold Grape with PE",
"Flu Relief Therapy Day Time",
"Tukol Max Action Cold Sore Throat and Cough",
"Daytime Nighttime Cold and Flu",
"Allergy Multi-Symptom",
"Childrens Triacting Nighttime Cold and Cough ReadyInCase",
"Daytime Severe Cold and Flu Relief",
"Tukol Max Action Severe Congestion and Cough",
"Hemorrhoidal",
"Day Time Cold and Flu Non Drowsy ReadyInCase",
"Hemorrhoidal",
"Cold and Flu",
"NEXT Severe Cold, Flu and Sore Throate Night Max Strength",
"DayQuil Severe Cold and Flu",
"Cold and Allergy Childrens",
"Daytime Nighttime Severe Cold and Flu",
"Daytime Nighttime Severe Cold and Flu",
"Topcare Day Time Cold and Flu",
"Mucus Relief Cold and Sinus Maximum Strength",
"Day Time Cold Multi-Symptom Cool Blast",
"Sinus Congestion and Pain",
"Daytime Nighttime Cold and Flu",
"NyQuil Severe",
"Topcare Tussin CF Max",
"Tussin CF Multi Symptom Cold Adult",
"Topcare Mucus Relief Severe Congestion and Cold",
"Acti PE",
"Allergy",
"Good Sense Severe Daytime Cold and Flu",
"Daytime Cold and Flu Non Drowsy",
"Daytime Cold Flu multi Symptom",
"Topcare Mucus Relief Cold Flu and Sore Throat",
"Hemorrhoidal",
"Alka Seltzer Plus Cold",
"Signature Care Hemorrhoidal",
"Advil Sinus Congestion and Pain Relief",
"Daytime Nighttime Cold and Flu Relief Multi-Symptom",
"DayTime",
"Day Time",
"Antiflu powder",
"Quality Choice Hemorrhoidal",
"Congestion Relief",
"Advil Allergy and Congestion Relief",
"Daytime Cold Flu multi Symptom",
"Daytime Nighttime Cold and Flu Relief Multi-Symptom",
"Complete Cold Relief",
"Sinus Congestion and Pain Severe Daytime,Non-Drowsy",
"Winco Hemorrhoidal",
"Sinus Congestion and Pain",
"Shoprite Day Calm Severe",
"Nitetime Cold and Flu",
"Sinus and Headache",
"SanaTos Day and Night Multi Symptom",
"Acetaminophen Congestion and Pain",
"Severe Sinus",
"Dg Health Cold and Flu Relief",
"ShopRite Adult Tussin",
"Shoprite Sinus Congestion and Pain",
"DG Health tussin cf adult cough and cold",
"Dg Health Cold Plus Flu Relief",
"DG Health Cold and Flu Relief Daytime",
"Cold and Flu Relief Multi-Symptom",
"Shoprite Congestion and Pain",
"DG Health Tussin",
"Congestion Relief",
"Dg Health Cold and Flu Relief",
"DG Health Cold and Flu Relief",
"DG Health Tussin",
"DG Health Mucus Relief",
"shop rite Day Severe Cold Night Cold and Flu",
"shop rite Day Severe Cold Night Cold and Flu",
"Childrens Multi-Symptom Cold and Fever Relief",
"Daytime Cold and Flu",
"Antigrip",
"Dometuss",
"Mucus Relief Cold Flu and Sore Throat Maximum Strength",
"Fast Acting Mucus Relief Maximum Strength Severe Cough and Congestion",
"Day Time Severe",
"Childrens Multi-symptom Cold",
"CounterAct Night",
"Mucus Relief Cold and Sinus Maximum Strength",
"Flu Relief Therapy Night Time",
"Sine Off Maximum Strength",
"Exchange Select Hemorrhoidal",
"Childrens Plus Flu",
"Daytime Severe",
"Childrens Plus Multi Symptom Cold DYE FREE",
"Childrens Plus Multi Symptom Cold",
"Daytime Nighttime Cold and Flu Relief",
"CounterAct Day",
"Sanatos Multi Symptom Daytime",
"Severe Nighttime Cold and Flu Relief",
"Day Time",
"ShopRite Day Calm Severe",
"Nighttime Cold and Flu Maximum Strength",
"Severe Cold and Cough Night Time",
"Good Sense Hemorrhoidal Maximum Strength Pain Relief",
"Leader Daytime Cold and Flu",
"Good Sense Sinus plus Headache",
"Good Sense Sinus Congestion and Pain",
"Mucus Relief Congestion Cough Maximum Strength Severe Congestion and Cough",
"Smart Sense Sinus",
"CareOne Cold Flu and sore throat",
"Leader sinus relief",
"Severe Cold and Cough Relief Daytime",
"Good Sense Tussin CF",
"CareOne DayTime Cold and Flu",
"Cold Flu and Sore Throat Maximum Strength",
"CareOne Cold and Sinus",
"Daytime Nighttime Severe Cold and Flu Relief",
"Daytime Nighttime Severe Cold and Flu Relief",
"Good Sense Daytime",
"Smart Sense Sinus and Headache",
"Severe Cold and Flu Relief Daytime",
"Good Sense Daytime non drowsy cold and flu",
"CareOne Daytime Nighttime Cold and Flu",
"Lil Drug Store Tylenol Cold plus Flu Severe",
"DayTime and NiteTime",
"Good Sense Cold Max",
"Good Sense Cold Head Congestion Severe",
"Leader Tussin CF",
"Lil Drug Store Tylenol Sinus Severe",
"Smart Sense sinus plus headache",
"Smart Sense sinus plus headache",
"Cold and Allergy Maximum Strength",
"Nite Time Cold and Flu",
"severe cold and sinus relief PE",
"DG Health Cold and Flu Relief",
"CareOne Sinus plus Headache",
"Maximum Strength Congestion and Headache",
"Day Severe Cold Night Cold and Flu",
"Day Severe Cold Night Cold and Flu",
"Mucus Relief Severe Congestion Cough Night Time Cold and Flu Maximum Strength",
"Mucus Relief Severe Congestion Cough Night Time Cold and Flu Maximum Strength",
"Dg Health Childrens Mucus Relief",
"Sinus Pressure and Pain PE Maximum Strength",
"Cold and Flu Relief Daytime",
"Severe cold and flu Nighttime",
"CareOne Sinus Relief Severe",
"Daytime Nighttime Cold and Flu",
"Stonarhini",
"Allergy Relief Multi-Symptom",
"Leader Daytime Severe Cold and Flu",
"CareOne Cold plus Flu Severe",
"Topcare Day Time Nite Time Cold and Flu Relief",
"Smart Sense Severe Cold and Flu NightTime",
"Good Sense Childrens Mucus Relief",
"Good Sense Mucus Relief cold flu and sore throat",
"Equaline congestion relief",
"Equaline Childrens Mucus Relief",
"Mucus Relief Severe Congestion and Cough Maximum Strength",
"Good Sense Allergy Multi Symptom",
"Smart Sense Daytime Nighttime Cold and Flu",
"Smart Sense Daytime Nighttime Cold and Flu",
"Good Sense Mucus Relief Cold and Sinus",
"Equaline Tussin Multi Symptom",
"Good Sense Severe NightTime Cold and Flu",
"Hemorrhoid Master",
"Equaline Daytime Cold and Flu Relief",
"Cold and Flu Relief",
"Smart Sense DayTime",
"Smart Sense Sinus Relief",
"Smart Sense daytime cold and flu",
"Smart Sense cold flu and sore throat",
"Allergy",
"Good Sense Severe Cold",
"Smart Sense Sinus Relief",
"Smart Sense Sinus Relief",
"DAY TIME COLD and FLU FORMULA",
"Tussin CF",
"Smart Sense nighttime cold and flu",
"Equaline Hemorrhoidal",
"Vanacof DMX",
"Severe Cough and Congestion Maximum Strength",
"Cold Multi Symptom",
"Smart Sense Severe Cold",
"Harris Teeter DayTime",
"Harris Teeter Tussin",
"Good Sense Tussin CF Max",
"Daytime Nighttime Cold Flu Relief",
"Cold and Allergy",
"Mucus Relief Cold Flu and Sore Throat Maximum Strength",
"Daytime Nighttime Cold Flu Relief",
"Tussin CF Adult Maximum Strength",
"Humana Pharmacy Daytime Cold and Flu Relief",
"Daytime Cold and Flu",
"Humana Pharmacy Sinus Relief",
"Daytime Cold and Flu Relief Multi-Symptom",
"Daytime Cold and Flu Relief",
"Up and Up Daytime Cold and Flu",
"NIGHT TIME COLD and FLU FORMULA",
"Acetaminophen Dextromethorphan HBr Guaifenesin Phenylephrine HCl",
"Nighttime Cold and Cough Sugar-Free",
"Daytime SEVERE COLD and FLU",
"Wal-Dryl PE Allergy and Sinus",
"Nighttime SEVERE COLD and FLU",
"Up and Up Daytime Severe Cold Nighttime Cold and Flu",
"Up and Up Daytime Severe Cold Nighttime Cold and Flu",
"Mucus Relief Severe Congestion and Cough Maximum Strength",
"Up and Up Cold Flu Relief Day Night",
"Up and Up Fast Mucus Relief Severe Cold",
"Up and Up Daytime Nighttime Cold and Flu",
"Up and Up Mucus Relief",
"Good Sense Severe Daytime Cold and Flu",
"Good Neighbor Pharmacy Cold Multi Symptom",
"Flu Relief Therapy Severe Cough and Cold Nighttime",
"Careone Sinus Sever Congestion Relief",
"Daytime cold and flu relief",
"Childrens Dibromm Cold and Cough",
"Night Time Sinus",
"Day Time Sinus Pain Reliever, Nasal Decongestant",
"Daytime Flu Relief Therapy Severe Cough and Cold",
"Childrens Dibromm Cold and Allergy",
"H E B MAX SEVERE CONGESTION and COUGH Maxium Strength",
"Sinus Relief",
"Sinus Relief",
"Cold and Flu Daytime",
"Good Sense Effervescent Cold Relief",
"Mucus Relief Severe Congestion and Cough Maximum Strength",
"Childrens Plus Multi Symptom Cold",
"Advil Multi-Symptom Cold and Flu",
"Childrens Plus Flu",
"Careone Sinus Relief Day Time Night Time",
"Careone Sinus Relief Day Time Night Time",
"CareOne sinus relief day time sinus relief night time",
"CareOne sinus relief day time sinus relief night time",
"Equaline Daytime Severe Cold and Flu Relief",
"Tussin Multi Symptom Cold CF Adult",
"Mucinex Fast-Max Cold, Flu and Sore Throat",
"Equaline Mucus Relief",
"Daytime Non Drowsy",
"Maximum Strength Mucinex Sinus-Max Pressure, Pain and Cough",
"Childrens Dimetapp Nighttime Cold and Congestion",
"Mucus Relief Cold and Sinus Maximum Strength",
"Flu Relief Therapy Severe Cough and Cold Nighttime",
"Cold and Flu Severe",
"CVS Health Hemorrhoidal Cream",
"Mucinex Fast-Max Night Time Cold and Flu",
"DayTime/NiteTime Severe Cold and Flu Maximum Strength",
"DayTime/NiteTime Severe Cold and Flu Maximum Strength",
"Cold and Allergy Maximum strength",
"Maximum Strength Mucinex Sinus-Max Severe Congestion and Pain Clear and Cool",
"Mucinex Fast-Max Cold, Flu and Sore Throat",
"Mucus Relief Sinus Congestion Daytime Nighttime Maximum Strength",
"Mucus Relief Sinus Congestion Daytime Nighttime Maximum Strength",
"Cold and Flu Daytime, Nighttime, Maximum Strength",
"Cold and Flu Daytime, Nighttime, Maximum Strength",
"Smart Sense Multi Symptom Cold",
"Severe Cold and Cough Relief Nighttime",
"Fedrin",
"Mucinex Fast-Max Cold and Flu",
"Mucinex Fast-Max Severe Congestion and Cough",
"Cold and Allergy PE",
"Topcare Nite Time Day Time Cold and Flu Relief",
"Mucinex Sinus-Max Severe Congestion and Pain, Maximum Strength",
"Mucinex Fast-Max Congestion and Headache",
"Robitussin Severe Multi-Symptom Cough Cold Flu Nighttime",
"Childrens Allergy Plus Congestion",
"Mucinex Fast-Max Cold, Flu and Sore Throat Clear and Cool",
"Mucus Multi Symptom Cold Relief Childrens",
"Cold and Flu Relief Daytime",
"Mucinex Fast-Max Cold, Flu and Sore Throat",
"Cold and Allergy Relief",
"Mucus Relief Cold Flu and Sore Throat Maximum Strength",
"Clear Eyes Pure Relief Multisymptom",
"Hemorrhoidal",
"Severe Cold and Cough Relief Nighttime",
"Meijer Effervescent Cold Relief",
"Maximum Strength Mucinex Fast-Max Cold and Flu",
"Flu Relief Therapy Daytime",
"Daytime",
"Sinus and Allergy",
"Vicks Sinex Severe All in One Sinus Mucus",
"Acetaminophen, Guaifenesin, Dextromethorphan HBr, Phenylephrine HCl",
"Preparation H",
"Preparation H",
"DAY TIME Cold Flu Medicine",
"Vicks Sinex Severe Pressure and Pain",
"Vicks Sinex Severe All in One Sinus",
"Day Severe Cold and Night Cold and Flu Maximum Strength",
"Day Severe Cold and Night Cold and Flu Maximum Strength",
"Daytime Nitetime Cold and Flu",
"Daytime Nitetime Cold and Flu",
"Severe sinus Congestion Relief",
"Nighttime Sinus and Congestion Relief",
"Nite Time Cold and Flu",
"NiteTime Sinus Relief",
"Mucus Relief Severe Congestion and Cough Maximum Strength",
"Vicks Sinex Severe Congestion",
"COLD FLU and SORE THROAT RELIEF",
"COLD FLU and SORE THROAT RELIEF",
"Mucinex Fast-Max Severe Congestion and Cough Clear and Cool",
"Nighttime Cold and Flu",
"DAY Cold and Flu Plus and NIGHTTIME Cold and Flu Plus",
"DAY Cold and Flu Plus and NIGHTTIME Cold and Flu Plus",
"DayTime Cold and Flu",
"Nighttime sinus",
"Daytime Cold and Flu",
"Daytime Sinus and Congestion",
"Daytime Mucus Relief Severe Cold/Nighttime Mucus Relief Cold and Flu",
"Daytime Mucus Relief Severe Cold/Nighttime Mucus Relief Cold and Flu",
"Severe Cold and Cough Relief Daytime",
"Maximum Strength Mucinex Fast-Max Day Time Cold and Flu and Maximum Strength Mucinex Fast-Max Night Time Cold and Flu",
"Maximum Strength Mucinex Fast-Max Day Time Cold and Flu and Maximum Strength Mucinex Fast-Max Night Time Cold and Flu",
"Good Sense Severe Day Time Cold and Flu",
"Health Mart daytime",
"Mucinex Fast-Max Congestion and Headache",
"TheraPlus Plus",
"Severe Cold and Flu Daytime Non Drowsy Nighttime",
"Severe Cold and Flu Daytime Non Drowsy Nighttime",
"Severe Cold Multi Symptom",
"Mucus Relief Cold Flu and Sore Throat Maximum Strength",
"Daytime Nighttime Cold Flu Relief",
"Multi-symptom Daytime",
"COLD and FLU DAYTIME MAXIMUM STRENGTH NON-DROWSY SEVERE",
"Childrens Cold and Allergy Relief",
"Daytime Nighttime Cold and Flu Relief Multi-Symptom",
"Daytime Cold and Flu Relief",
"Mucus Relief Severe Congestion and Cough Maximum Strength",
"Multi-symptom Daytime",
"Daytime Severe Cold and Cough Relief",
"Flu Relief Therapy Night Time",
"Non-Drowsy Daytime Multi Symptom Cold and Flu Relief",
"Severe Sinus Congestion and Cough Daytime Non-drowsy / Nightime",
"Severe Sinus Congestion and Cough Daytime Non-drowsy / Nightime",
"Severe Cold and Flu Relief Daytime",
"ACETAMINOPHEN DEXTROMETHORPHAN HYDROBROMIDE and PHENYLEPHRINE HYDROCHLORIDE",
"Promethazine Hydrochloride and Phenylephrine Hydrochloride",
"Tusnel-DM Pediatric",
"Rompe Pecho CF",
"Stona-S",
"Otis Clapp Mygrex",
"Medi First Sinus Pain and Pressure",
"Medi First Plus Sinus Pain and Pressure",
"Stona Cough",
"Medi First Sinus Pain and Pressure",
"Medi First Plus Sinus Pain and Pressure",
"Otis Clapp Mygrex",
"Triponel",
"Tusnel Pediatric Drops",
"Stona",
"Cold and Cough Day Time Childrens",
"Severe cold and flu Nighttime",
"Severe Sinus Congestion Allergy and Cough Formula",
"Daytime Sinus Relief and Nighttime Sinus Relief",
"Daytime Sinus Relief and Nighttime Sinus Relief",
"DayTime Maximum Strength Cold and Flu",
"DayTime Sinus",
"Daytime Cold and Flu Multi-symptom Relief",
"DayTime Cold and Flu",
"Cold and Flu Multi-symptom Relief/cold and Flu Nighttime Relief",
"Severe sinus Congestion Relief",
"COLD FLU and SORE THROAT RELIEF",
"Nighttime Cold and Flu",
"Severe Nighttime Cold and Flu",
"Bliss GVS Hemorrhoidal",
"NightTime Maximum Strength Cold and Flu",
"Daytime Cold and Flu",
"Theraflu Sinus and Pain",
"Mucus Relief Cold Flu Sore Throat Maximum Strength",
"DAYTIME COLD and FLU",
"DayTime Sinus",
"DayTime Severe Cold and Flu Relief",
"Cold, Flu and Sore Throat",
"Nighttime Severe Cold and Flu Relief",
"DDM Day time and Nite time cold and flu",
"Lil Drug Store Allergy Sinus Relief",
"Lil Drug Store Allergy Sinus Relief",
"DAY TIME Cold Flu Medicine",
"DAY TIME and NIGHT TIME COLD and FLU FORMULA",
"DAY TIME and NIGHT TIME COLD and FLU FORMULA",
"Night Time Sinus Relief",
"Day Time Sinus Relief",
"CVS Daytime COLD and FLU RELIEF and Nighttime COLD and FLU RELIEF",
"CVS Daytime COLD and FLU RELIEF and Nighttime COLD and FLU RELIEF",
"Daytime Congestion Pressure and Pain",
"COLD FLU and SORE THROAT RELIEF",
"Lil Drug Store Cold Relief",
"Lil Drug Store Cold Relief",
"Maximum Strength Nighttime Cold/Flu Relief",
"Alka-Seltzer Plus",
"Severe sinus Congestion Relief",
"Daytime and Nighttime Cold and Flu",
"Fargelin Hemorrhoidal",
"Hemorrhoidal",
"Hemorrhoidal",
"Hemorrhoidal",
"Alka-Seltzer Plus Severe Sinus Cough and Cold",
"Family Wellness",
"Vicks DayQuil and Vicks NyQuil Severe Cold and Flu",
"Vicks DayQuil and Vicks NyQuil Severe Cold and Flu",
"Vicks DayQuil and Vicks NyQuil Severe Cold and Flu",
"Vicks DayQuil and Vicks NyQuil Severe Cold and Flu",
"Vicks DayQuil and Vicks NyQuil Severe Cold and Flu",
"Vicks DayQuil and Vicks NyQuil Severe Cold and Flu",
"Cold and Flu Severe",
"Vicks DayQuil Severe Cold and Flu",
"Vicks DayQuil Severe and Vicks NyQuil Severe Cold and Flu",
"Vicks DayQuil Severe and Vicks NyQuil Severe Cold and Flu",
"Vicks DayQuil and Vicks NyQuil Cold and Flu Multi-Symptom Relief/Cold and Flu Nighttime Relief",
"Vicks DayQuil Cold and Flu Multi-Symptom Relief",
"Vicks DayQuil and Vicks NyQuil Cold and Flu Multi-Symptom Relief/Cold and Flu Nighttime Relief",
"Vicks DayQuil and Vicks NyQuil Cold and Flu Multi-Symptom Relief/Cold and Flu Nighttime Relief",
"Vicks DayQuil and Vicks NyQuil Cold and Flu Multi-Symptom Relief/Cold and Flu Nighttime Relief",
"Daytime Nighttime Cold and Flu Relief Multi-Symptom",
"Wal Flu Severe",
"Wal Flu Severe",
"DayQuil and Nyquil Severe plus Vicks VapoCool Cold and Flu",
"DayQuil and Nyquil Severe plus Vicks VapoCool Cold and Flu",
"Day and Night Severe Sinus Congestion and Cough Maximum Strength",
"Day and Night Severe Sinus Congestion and Cough Maximum Strength",
"Cooling Severe Nighttime",
"Severe sinus Congestion Relief",
"Promethazine HCl, Phenylephrine HCl, Codeine Phosphate",
"Cooling Severe Daytime Cooling Severe Nighttime",
"Cooling Severe Daytime Cooling Severe Nighttime",
"Hem Rid",
"Basic Care Sinus Plus Headahce",
"Equate Health Non Drowsy DAY Cold and Flu Plus and NIGHTTIME Cold and Flu Plus",
"Equate Health Non Drowsy DAY Cold and Flu Plus and NIGHTTIME Cold and Flu Plus",
"Daytime Cold Flu Non Drowsy",
"Alka-Seltzer Plus Day Severe Cold Plus Flu",
"Contac Cold and Flu Night",
"Nivanex DMX",
"Alka-Seltzer Plus Night Severe Cold and Flu",
"Childrens Tussnex",
"Dr. Cocoa Daytime Cough and Cold",
"Childrens Metapp Daytime",
"Maximum Strength Cold Flu and Sore Throat",
"Tussnex FM Cold, Flu and Sore Throat",
"DayTime Cold Flu Non Drowsy",
"Dr. Cocoa Nighttime Cough and Cold",
"Wal Flu Severe Cold",
"Contac Cold and Flu Day",
"Alka-Seltzer Plus Day and Night Severe Cold and Flu",
"Alka-Seltzer Plus Day and Night Severe Cold and Flu",
"Multi Symptom Cold",
"Multi Symptom Cold",
"Cough and Cold XL3 Xtra",
"Contac Cold and Flu Day Night",
"Contac Cold and Flu Day Night",
"Childrens Tussnex Multi-symptom cold",
"Tussnex FM Severe cough and congestion",
"Deconex IR",
"Alahist CF",
"Polytussin DM",
"Cold Multi-Symptom Severe Day Time",
"Alka-Seltzer Plus Cold Day and Night",
"Alka-Seltzer Plus Cold Day and Night",
"Hemorrhoidal",
"Swift Sinus Pain",
"Sinus Pain",
"Cooling Severe Daytime",
"Wal Flu Severe Cold and Cough",
"Cooling Severe Nighttime",
"Tussnex FM Cold and Sinus",
"Cough and Cold XL3 Xtra",
"Cough and Cold XL3 Xtra",
"Cold and Sinus Pain Relief",
"DEXTROMETHORPHAN HYDROBROMIDE, Guaifenesin, and PHENYLEPHRINE HYDROCHLORIDE",
"Dextromethorphan Hydrobromide, Guaifenesin, Phenylephrine Hydrochloride",
"Dexbrompheniramine Maleate and Phenylephrine Hydrochloride",
"Family Wellness Effervescent Cold Relief Orange",
"Lil Drug Store NyQuil Severe Cold and Flu, Max Strength",
"Ru-Hist D",
"Family Wellness Effervescent Cold Relief Original",
"Poly-Tussin AC",
"M-end PE",
"Sinus Congestion and Pain Relief Non-Drowsy",
"Histex-DM",
"Sinus and Headache Daytime",
"Family Care Hemorrhoidal",
"TexaClear Kids Cough and Cold",
"Texaclear Daytime Cough Cold/flu",
"Daytime Mucus Relief Severe Cold and Nighttime Cold and Flu Maximum Strength",
"Daytime Mucus Relief Severe Cold and Nighttime Cold and Flu Maximum Strength",
"Sudafed PE Day Plus Night Sinus Congestion",
"Sudafed PE Day Plus Night Sinus Congestion",
"Health Mart Day Time Cold and Flu Night Time Cold and Flu",
"SUDAFED PE Head Congestion Plus Flu Severe",
"Day Time Multi-Symptom Flu Cold Medicine",
"Sudafed PE Pressure Plus Pain Plus Cold",
"SUDAFED PE Pressure PLUS Pain PLUS Mucus",
"Sunmark Cold and Allergy Childrens",
"Texaclear Night Time Cough Cold/flu",
"Benadryl Allergy Plus Congestion",
"Harris Teeter Sinus Relief",
"Harris Teeter Sinus Relief",
"Multi-Symptom Sinus Severe Congestion",
"Daytime Nighttime Cold Flu Relief",
"Cold Relief Severe, Multi-symptom",
"Tylenol Cold Plus Flu Severe",
"Maximum Strength Mucus Relief Severe Congestion and Cough Cooling Menthol",
"Cold Multi-Symptom",
"Cold Multi-Symptom",
"Sinus Congestion and Pain Non-Drowsy",
"Hemorrhoidal Maximum Strength Pain Relief",
"Health Mart Childrens Allergy Plus Congestion",
"Sunmark Tussin CF",
"Cold and Head Congestion Relief Severe",
"Broncofin",
"Cold and Flu Daytime, Nighttime, Multi-Symptom",
"Cold and Flu Daytime, Nighttime, Multi-Symptom",
"Health Mart Daytime",
"Day Cold and Flu Night Cold and Flu",
"Day Cold and Flu Night Cold and Flu",
"Severe Cold and Flu Relief Daytime",
"Topcare Day Time Cold and Flu",
"Daytime Cold and Flu",
"Severe Nighttime Cold and Flu",
"Non Drowsy DAYTIME and NIGHTTIME Sinus Congestion and Cough Relief",
"Non Drowsy DAYTIME and NIGHTTIME Sinus Congestion and Cough Relief",
"Severe Cold and Flu Daytime Non Drowsy Nighttime",
"Severe Cold and Flu Daytime Non Drowsy Nighttime",
"Cooling Severe Daytime",
"Core Values Tussin CF",
"Multi-Symptom Allergy",
"Walgreens Maximum Strength Non-Drowsy Day and Night Sinus and Cold",
"Walgreens Maximum Strength Non-Drowsy Day and Night Sinus and Cold",
"Sunmark Cold and Flu Severe",
"Phenyl-Lido",
"Cold-Flu Relief Multi Symptom",
"Daytime Cold, Nighttime Cold multi-symptom",
"Daytime Cold, Nighttime Cold multi-symptom",
"Circle K Daytime Cold and Flu",
"Family Wellness",
"Cold and Flu Relief Severe",
"Rompe Pecho Max Multi Symptoms",
"Quality Choice Hemorrhoidal",
"Rompe Pecho SF FLU",
"Maximum Strength Mucinex Sinus-Max Severe Congestion and Pain",
"Alka-Seltzer Plus Multi-Symptom Cold Day and Night",
"Alka-Seltzer Plus Multi-Symptom Cold Day and Night",
"Cold and Flu Daytime Severe, Nighttime Severe",
"Cold and Flu Daytime Severe, Nighttime Severe",
"Pain Relief Non-Drowsy, Daytime",
"Nighttime Cold and Flu Maximum Strength",
"Cooling Severe Daytime Cooling Severe Nighttime",
"Cooling Severe Daytime Cooling Severe Nighttime",
"Desenfriol-D",
"Desenfriol-D",
"Desenfriol-D",
"Cold/Flu Multi-Symptom Relief Daytime/Nighttime",
"Cold/Flu Multi-Symptom Relief Daytime/Nighttime",
"Hemorrhoidal",
"Multi-Symptom Daytime Cold Rapid Release",
"Sinus Congestion and Pain Daytime",
"Sinus Congestion and Pain Relief Non-Drowsy",
"Daytime Cold and Flu Relief Non Drowsy",
"Daytime and Nighttime Cold and Flu Relief",
"Daytime and Nighttime Cold and Flu Relief",
"Wal-Phed PE Pressure plus Pain Maximum Strength Non-Drowsy",
"Sinus and Headache",
"Daytime Cold and Flu Non Drowsy",
"Day Time Night Time Cold and Flu",
"Allergy and Pain Relief Multi-Symptom",
"Cold Formula Daytime Nighttime, Non-Aspirin, Multi-Symptom",
"Cold Formula Daytime Nighttime, Non-Aspirin, Multi-Symptom",
"Daytime Nighttime Cold and Flu Relief Multi-Symptom",
"Severe Cold Daytime",
"Basic Care Daytime Cold and Flu",
"COLD and FLU",
"Non Drowsy DAY Cold and Flu Plus and NIGHTTIME Cold and Flu Plus",
"Non Drowsy DAY Cold and Flu Plus and NIGHTTIME Cold and Flu Plus",
"CapCof",
"Aquanaz",
"COLD and FLU",
"Cold Multi-Symptom Night-time",
"Cold and Allergy",
"Daytime Severe Cold And Flu Relief Maximum strength",
"Multi-symptom Daytime",
"Giltuss Total Release",
"Sinus Headache PEMaximum Strength Non-Drowsy Maximum Strength Non-Drowsy",
"Multi-symptom Daytime",
"Multi-symptom Daytime",
"Cold and Flu Daytime",
"Day Time",
"Severe Congestion and Cough",
"Daytime Severe Cold and Flu",
"Cold and Flu DayTime",
"Cold and Flu Severe",
"Severe Congestion and Cold Relief Maximum Strength, Multi Symptom",
"Daytime Nighttime Cold Flu Relief",
"DAYTIME and Nighttime Cold and Flu",
"DAYTIME and Nighttime Cold and Flu",
"Flu and Severe Cold and Cough Daytime",
"NovexCold",
"multi-symptom cold relief Daytime, Nighttime",
"multi-symptom cold relief Daytime, Nighttime",
"Mucus Relief Sinus",
"Hemorrhoidal",
"Up and Up Nighttime Severe Cold and Flu",
"Severe Sinus Daytime, Non-Drowsy",
"Mucus Relief PE Sinus Congestion",
"Deconex Dmx",
"Sinus and Headache Daytime Non-Drowsy",
"Fast Maximum Night Time Cold and Flu",
"Dibromm Cold and Allergy Relief childrens",
"DAYTIME and Nighttime Sinus Relief",
"DAYTIME and Nighttime Sinus Relief",
"Alahist D",
"Allergy and Sinus Headache",
"Daytime Severe Cold and Cough",
"Acetaminophen, Phenylephrine Hydrochloride, Chlorpheniramine Maleate",
"AcetaFlu DayTime",
"AcetaFlu NightTime Effervescent",
"AcetaFlu NightTime",
"Cold and Flu DayTime, NightTime Severe",
"Cold and Flu DayTime, NightTime Severe",
"Daytime Severe",
"Sinus and Allergy Relief",
"AcetaFlu DayTime Effervescent",
"Night Time Cold and Flu",
"Nighttime",
"Daytime Severe Cold and Flu Relief Softgels",
"Acetaminophen, Phenylephrine Hydrochloride, Chlorpheniramine Maleate",
"Severe Nighttime Cold and Flu",
"Nite Time Day Time",
"Ed A-hist DM",
"Ed A-hist",
"Childrens Delsym Cough Plus Chest Congestion DM and Delsym Cough Plus Cold Night Time",
"Rymed",
"Ed-A-hist DM",
"Winco Foods Childrens Multi Symptom Cold",
"Daytime Cold and Flu",
"Cold FAid",
"Maximum Strength Severe Congestion Relief",
"CVS Maximum Strength Severe Congestion and Cough",
"CVS Maximum Strength Severe Congestion and Cough Overnight Cold and Flu Clear and cool",
"CVS Maximum Strength Severe Congestion and Cough Overnight Cold and Flu Clear and cool",
"Walgreens Maximum Strength Non Drowsy Day and Night Cold and Flu",
"Walgreens Maximum Strength Non Drowsy Day and Night Cold and Flu",
"Maximum Strength Congestion and Headache",
"Severe Cold and Flu Daytime Non Drowsy Nighttime",
"Severe Cold and Flu Daytime Non Drowsy Nighttime",
"Cold and Allergy",
"Daytime Cold and Flu",
"Sinus Congestion and Pain",
"Cold and Sinus Maximum Strength",
"Severe Cold Maximum Strength, Multi-Symptom",
"Sinus Severe Daytime",
"Daytime Mucus Relief Severe Cold and Nighttime Cold and Flu Maximum Strength",
"Daytime Mucus Relief Severe Cold and Nighttime Cold and Flu Maximum Strength",
"Childrens Dimetapp Multi-Symptom Cold and Flu",
"Multi-symptom Daytime",
"Rynex DM",
"Childrens Cold and Allergy Relief",
"Basic Care Nighttime Cold and Flu",
"Multi-Symptom Mapap Cold Formula",
"Medique CCP Caffeine Free",
"Sinus Pressure and Pain and Cough",
"Tylenol Sinus Severe",
"Otis Clapp Valihist",
"Medique Medicidin D",
"Alka-Seltzer Plus Severe Cold and Flu PowerFast Fizz",
"Daytime and Nighttime Cold/Flu Relief",
"Daytime Cold/Flu Relief Softgels",
"Sinus Relief Pressure and Pain",
"Alka-Seltzer Plus Severe Cold Powerfast Fizz Night",
"Alka-Seltzer Plus Severe Cold PowerFast Fizz Non Drowsy",
"Sinus Headache and Pain Day, Non-drowsy",
"Severe Congestion Relief Maximum Strength Sinus",
"TYLENOL Cold Max Day",
"TYLENOL Cold Plus Flu Severe",
"Tylenol Cold Plus Head Congestion Severe",
"Tylenol Sinus Plus Headache Day",
"Tylenol Cold Plus Flu Severe Day/night",
"Tylenol Cold Plus Flu Severe Day/night",
"Basic Care Daytime Nighttime Cold and Flu",
"Basic Care Daytime Nighttime Cold and Flu",
"Tussin CF Non Drowsy",
"Alka-Seltzer Plus Severe Cold PowerFast Fizz",
"Alka-Seltzer Plus Severe Cold PowerFast Fizz",
"Daytime Nightime Severe Cold",
"Daytime Nightime Severe Cold",
"Walgreens Hemorrhoidal",
"Severe Cold Cough and Flu Relief Daytime",
"Vicks Severe Cold and Flu",
"Cold, Flu, and Sore Throat",
"Daytime Cold and Flu Relief",
"Vicks Severe Cold and Flu",
"Cold and Flu Relief",
"Fast Mucus Relief",
"Vicks DayQuil NyQuil Severe Cold and Flu combo",
"Vicks DayQuil NyQuil Severe Cold and Flu combo",
"Doctor Manzanilla Cough and Cold",
"Head and Cold",
"Cold and Flu daytime",
"Cold, Flu, and Sore Throat",
"Sinus Congestion and Pain Daytime, Non-drowsy",
"Mucus Relief Severe Sinus Congestion Maximum Strength",
"Severe Sinus Congestion and Pain Maximum Strength",
"Sinus Relief Maximum Strength",
"Sunmark Hemorrhoidal",
"Dimaphen DM",
"Hemorrhoidal",
"Mucus Relief Cold Flu and Sore Throat Max Maximum Strength",
"Sinus Relief Severe Congestion Maximum Strength",
"Multi-Symptom Cold Flu and Sore Throat Maximum Strength",
"Cold, Flu and Sore Throat Relief Maximum Strength, Multi Symptom",
"Fast Mucus Relief",
"Childrens Delsym Cough Plus Cold Night Time",
"Cold and Flu Daytime Severe",
"Sinus Pain and Congestion Daytime",
"Childrens Cold and Cough",
"Hemorrhoidal",
"Cold Relief Multi-Symptom",
"Cold Relief Multi-Symptom",
"Doctor Manzanilla Allergy and Decongestant Relief",
"PREPARATION H Maximum Strength",
"Cold and Flu Multi-Symptom Daytime/Nighttime Severe",
"Cold and Flu Multi-Symptom Daytime/Nighttime Severe",
"Nite time Severe Cold and Flu Maximum Strength",
"Meijer Maximum Strength Severe Congestion and Cough",
"Sinus Severe",
"severe sinus congestion relief Maximum Strength",
"Hemorrhoidal",
"Health Mart Adult Tussin",
"Sinus Congestion and Pain Relief Non-Drowsy, Daytime",
"Basic Care Daytime Nighttime Severe Cold and Flu",
"Basic Care Daytime Nighttime Severe Cold and Flu",
"Cold and Flu Daytime Severe",
"Pressure plus Pain plus Mucus Non-Drowsy",
"Cold Childrens, Multi Symptom",
"Pain Relief Non Drowsy Daytime",
"Preparation H",
"Severe Cold and Flu Daytime/nighttime",
"Severe Cold and Flu Daytime/nighttime",
"Hemorrhoidal",
"Nighttime Severe Cold and Flu",
"Sinus Congestion and Pain Maximum Strength",
"Baczol Cold Medicine",
"Daytime Liquid Caps",
"Childrens Cold and Cough Nighttime",
"Cold and Flu Severe Day Time / Night Time",
"Cold and Flu Severe Day Time / Night Time",
"Health Mart Cold and Cough childrens",
"Day Time Cold and Flu Relief non drowsy",
"Cold, Flu and Sore Throat Maximum Strength, Multi-Symptom",
"Cold Flu and Sore Throat Relief Maximum Strength",
"Childrens Multi Symptom Fever and Cold",
"Daytime Severe Cold and Flu",
"Daytime-nighttime Severe Cold and Flu",
"Daytime-nighttime Severe Cold and Flu",
"Stahist Tp",
"Nighttime Severe Cold and Flu",
"Sunmark Day time cold and flu",
"Mucinex Nightshift Severe Cold and Flu",
"Alka-Seltzer Plus Maximum Strength Cough, Mucus and Congestion Powermax",
"Alka-Seltzer Plus Maximum Strength Cough, Mucus and Congestion Day and Night",
"Alka-Seltzer Plus Maximum Strength Cough, Mucus and Congestion Day and Night",
"Sinus PE plus Allergy Maximum Strength",
"Mucinex Sinus-Max Pressure, Pain and Cough",
"Cold and Flu Nighttime Severe",
"DayTime Cold and Flu Non Drowsy",
"Alka-Seltzer Plus Cough, Mucus and Congestion Day and Night Powermax",
"Alka-Seltzer Plus Cough, Mucus and Congestion Day and Night Powermax",
"SanaTos Severe Cold and Cough Day Time",
"Cold and Flu Daytime, Nighttime",
"Severe Cold and Flu Relief",
"SanaTos Severe Cold and Cough Nighttime",
"Target Maximum Strength Cold Flu and Sore Throat Overnight Cold and Flu",
"CVS Severe Congestion and Pain Relief",
"Target Maximum Strength Cold Flu and Sore Throat",
"Mucus Relief Severe Congestion and Cough Multi Symptom Relief",
"Maximum Strength Mucinex Fast-Max Cold and Flu",
"Cold and Flu Daytime-nighttime",
"Cold and Flu Daytime-nighttime",
"Cold Flu Severe",
"Cold Flu Severe",
"Mucinex Childrens FreeFrom Multi-Symptom Cold and Stuffy Nose",
"Mucinex Childrens FreeFrom Multi-Symptom Cold and Flu Nighttime",
"ANTIGRIP Daytime",
"Mucinex Childrens FreeFrom Multi-Symptom Cold, Flu and Sore Throat",
"ANTIGRIP Nighttime",
"Sinus Congestion and Pain Severe",
"Mucinex FreeFrom Severe Congestion and Cough",
"Mucinex FreeFrom Cold and Flu Nighttime",
"Cetafen Cough and Cold",
"Maximum Strength Cold and Flu",
"Mucinex FreeFrom Cold and Flu Daytime",
"Mucinex FreeFrom Cold, Flu and Congestion",
"Mucus Relief Cold, Flu and Sore Throat",
"pressure and pain sinus relief PE NON-DROWSY",
"Sinus PE Pressure, Pain and Mucus",
"Severe Congestion and Cough Relief Maximum Strength",
"Green Guard Cough and Cold Relief",
"Cold and Flu Relief Non-Drowsy / Daytime Severe / Nighttime Severe",
"Cold and Flu Relief Non-Drowsy / Daytime Severe / Nighttime Severe",
"Sinus Relief Non-Drowsy Daytime",
"Severe Cold and Flu Relief",
"Sinus Congestion and Pain Severe",
"Multi-Symptom Cold",
"Cold, Flu and Sore Throat Maximum Strength",
"Cold and Flu Severe",
"Medique Decorel Forte Plus",
"Medi-First Cold Relief",
"Medi-First Plus Cold Relief",
"Cold and Flu Daytime Relief",
"CVS Overnight Cold and Flu Clear and Cool",
"Sinus and Allergy Maximum Strength",
"Severe Sinus Pain and Congestion Daytime",
"Green Guard Advanced Sinus Relief",
"Sinus Congestion and Pain Daytime",
"Mucus Relief PE",
"Doxylamine Succinate and Phenylephrine Hydrochloride",
"Severe Cough and Congestion and Cold and Flu Daytime, Nighttime",
"Severe Cough and Congestion and Cold and Flu Daytime, Nighttime",
"severe cold, cold and flu Daytime/Nighttime",
"severe cold, cold and flu Daytime/Nighttime",
"Nasal Decongestant PE and Pain Relief Maximum Strength",
"Father Johns Cough Medicine Plus",
"Crane Safety Cold Relief",
"Moore Medical Sinus Pain and Pressure Relief",
"Mucus Relief, Cold, Flu and Sore Throat Maximum Strength, Multi-Symptom",
"Moore Medical MooreBrand Severe Cold Relief",
"Mucinex Fast-Max Day Time Severe Congestion and Cough - Mucinex Fast-Max Night Time Cold and Flu Maximum Strength",
"Mucinex Fast-Max Day Time Severe Congestion and Cough - Mucinex Fast-Max Night Time Cold and Flu Maximum Strength",
"Allergy Multi-Symptom",
"Moore Medical Sinus Pain and Pressure Relief",
"Mucinex Sinus-Max Day Night",
"Mucinex Sinus-Max Day Night",
"Sinus Pressure and Pain",
"Sinus Congestion and Pain Nighttime",
"Sinus Congestion and Pain Non Drowsy",
"Cold and Flu Daytime",
"Allergy Multi-Symptom",
"Allergy Plus Sinus Headache",
"Severe Congestion and Cough Multi-Symptom Maximum Strength",
"Up and Up Cold and Flu Relief Multi Symptom Day and Night Combo Pack",
"Mucus Relief",
"Daytime Cold Relief Multi Symptom",
"Dimaphen",
"Acetaminophen, Dextromethorphan Hydrobromide, Phenylephrine Hydrochloride",
"Good Sense Sinus Relief",
"DEXTROMETHORPHAN HYDROBROMIDE, GUAIFENESIN, and PHENYLEPHRINE HYDROCHLORIDE",
"Night Time Cold Multi-Symptom",
"Cold DayTime, Multi-Symptom, Non-drowsy",
"Sinus Congestion and Pain Daytime Nighttime",
"Sinus Congestion and Pain Daytime Nighttime",
"Healthy Accents Sinus",
"Healthy Accents Sinus",
"Daytime Flu and Severe",
"Severe Cold Head Congestion",
"Sinus Congestion and Pain Relief",
"Severe Cold and Flu",
"Acetaminophen, Diphenhydramine Hydrochloride, Phenylephrine Hydrochloride",
"CVS Health Non Drowsy Daytime Cold and Flu Relief And Nighttime Cold and Flu Relief Day and Night Twin Pack",
"Topcare Sinus Congestion and Pain",
"Rx Act Cold and Allergy Childrens",
"Sinus and Allergy PE Maximum Strength",
"Adult Severe Congestion and Cough",
"Alka-Seltzer Plus Fast Packs Cold and Flu Formula",
"DayTime NiteTime Cold and Flu",
"Dimaphen",
"Severe Cold",
"Preferred Plus Cold and Flu Night Time",
"TexaClear Kids Cold Relief",
"Cold Multi-Symptom",
"Cold Multi-Symptom",
"Daytime NiteTime",
"Chlorpheniramine Maleate, Phenylephrine Hydrochloride",
"Promethazine hydrochloride and phenylephrine hydrochloride",
"Cold Head Congestion Daytime / Nighttime",
"Cold Head Congestion Daytime / Nighttime",
"Robitussin Peak Cold Maximum Strength Multi-symptom Cold",
"healthy accents cold and cough DM",
"Cold and Flu Severe",
"Day Time Cold Head Congestion Severe",
"Careone Allergy and Cough Severe Sinus Congestion",
"Leader Congestion Relief",
"Childrens mucus relief multi-symptom cold",
"Robitussin To Go Cough and Cold CF",
"Sanatos",
"CareOne Adult Tussin CF",
"Giltuss Pediatric",
"XL-3 Cold",
"Alka-Seltzer Plus Day Cold and Flu",
"Childrens Plus Multi-Symptom Cold Grape with PE",
"Equate Daytime Nitetime",
"XL-3 Xtra",
"Leader Allergy Multi Symptom",
"Daytime Nitetime Sinus",
"Daytime Nitetime Sinus",
"Major Prep Hemorrhoidal",
"BroveX PEB",
"Preparation H Totables Burning Relief",
"G-P-tuss Dxp",
"Preparation H Totables Pain Relief",
"Cold",
"Cold",
"Smart Sense Daytime",
"Cold and Allergy",
"Entre-B",
"Topcare Hemorrhoidal Cooling",
"Acetaminophen, Dextromethorphan Hydrobromide, Guaifenesin, Phenylephrine Hydrochloride",
"MediGummies Cold and Sinus",
"Biobron SF",
"Allergy and Cold PE",
"Daytime Nighttime Severe Cough and Cold",
"Daytime Nighttime Severe Cough and Cold",
"Mydriatic-3",
"Hemorrhoidal",
"Major Prep Hemorrhoidal",
"Cooling Hemorrhoidal",
"Tylenol Cold Max Day",
"RectiCare Complete",
"RectiCare Complete",
"Day and Night Cold",
"Day and Night Cold",
"Allergy Relief",
"Dg Health Flu and Severe Cold and Cough",
"Daytime PE Nitetime",
"Leader Tussin",
"Day Relief Night Relief Free",
"Nighttime Flu and Severe",
"Sinus Congestion and Pain Daytime Nighttime",
"Sinus Congestion and Pain Daytime Nighttime",
"CVS Daytime Severe Cough and Cold",
"Preferred Plus Severe Cold",
"Cold and Flu Severe",
"Cold Relief Multi-symptom",
"Cold Relief Multi-symptom",
"Cold Pain Relief",
"Mucus Relief Cold Flu and Sore Throat",
"Severe Cold and Flu",
"Severe Cold and Flu",
"CVS Health Non-Drowsy Daytime Cold and Flu Relief Single Serve Cups Daytime",
"Equate Flu and Severe Cold and Cough",
"Good Sense Severe Sinus Congestion",
"Mucinex Fast-Max Severe Congestion and Cough",
"Care One Sinus",
"Care One Sinus",
"DayClear SINUS PAIN AND PRESSURE",
"DayClear COUGH COLD AND FLU",
"Preferred Plus Severe Day Time",
"Wal Tussin Adult Cough and Cold",
"TopCare Mucus Relief and Cold and Flu",
"TopCare Mucus Relief and Cold and Flu",
"Deconex DMX",
"Sinus Relief",
"Smart Sense Hemorrhoidal",
"Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hydrobromide, Phenylephrine Hydrochloride",
"Maxiphen DM",
"Daytime Mucus Relief Nighttime Cold and Flu",
"Daytime Mucus Relief Nighttime Cold and Flu",
"Tussi Pres",
"Cold Head Congestion Night Time",
"Leader Tussin CF Max",
"Sinus",
"Sinus",
"Acetaminophen, Diphenhydramine Hydrochloride, Phenylephrine Hydrochloride",
"Histex-PE",
"Cold Head Congestion Nighttime",
"Desgen DM",
"CareOne Mucus Relief Cold and Sinus",
"Acetaminophen, Diphenhydramine Hydrochloride, Phenylephrine Hydrochloride",
"TexaClear Kids Sinus Relief",
"Cold and Flu",
"Acetaminophen, Diphenhydramine Hydrochloride, Phenylephrine Hydrochloride",
"CareOne Daytime Cold Flu Relief",
"Preferred Plus Childrens Mucus Relief Multi Symptom Cold",
"Maxiphen",
"Night Time Cold and Flu",
"Severe Cold",
"Ed Chlorped D",
"Dr Manzanilla PE",
"Vazobid-PD",
"Severe Cold and Flu Night time",
"Mucus Relief D Immediate Release",
"Leader Flu and Severe Cold and Cough",
"Pressure Pain Cough PE",
"Sinus Congestion and Pain Severe",
"Leader Mucus Relief Cold and Sinus",
"Leader Flu and Severe Cold and Cough",
"Congestion Relief",
"Smart Sense Childrens Nighttime Cold and Cough",
"Smart Sense Sinus",
"Smart Sense Sinus",
"Daytime Severe Cold and Flu Relief Maximum Strength",
"Multi Symptom Fever and Cold Childrens",
"Contac Cold and Flu Maximum Strength",
"Leader Nite Time Severe Cold and Flu",
"Assured Childrens Cold and Cough",
"Daytime Nighttime Severe Cold and Flu",
"Daytime Nighttime Severe Cold and Flu",
"Leader Day Time Multi Symptom Cold Flu Relief",
"Hemorrhoidal",
"Good Sense cold multi symptom",
"Giltuss",
"Robitussin Peak Cold Nasal Relief",
"Assured Day time Cold and Cough",
"Leader Severe Sinus Congestion",
"M-Hist DM",
"Cold Head Congestion Nighttime",
"Contac Cold and Flu Day Night",
"Daytime Nighttime Cold and Flu Relief",
"Allergy D",
"Duravent PE",
"Acetaminophen, Dextromethorphan Hydrobromide, Guaifenesin, Phenylephrine Hydrochloride",
"Daytime Nighttime ClearTime",
"Daytime Nighttime ClearTime",
"Healthy Accents Hemorrhoidal",
"Hemorrhoidal Relief",
"Acetaminophen, Diphenhydramine Hydrochloride, Phenylephrine Hydrochloride",
"Acetaminophen, Dextromethorphan Hydrobromide, Guaifenesin, Phenylephrine Hydrochloride",
"Acetaminophen, Phenylephrine Hydrochloride",
"Pyrilamine-Phenylephrine",
"Pain and Sinus Reliever",
"Sinus Relief Congestion and Pain Nighttime",
"Cold Multi-Symptom",
"Up and Up Nighttime Daytime Cold and Flu",
"Contac Cold and Flu Day Night",
"Contac Cold and Flu Day Night",
"Niteclear Cold and Flu Relief",
"BroveX PEB DM",
"Robitussin Peak Cold Nighttime Nasal Relief",
"Day Time",
"Mucinex Fast-Max Cold and Sinus",
"ShopRite Day Calm",
"Leader Cold and Flu",
"Mapap Sinus Congestion and Pain Maximum Strength",
"Cold and Flu",
"Severe Cold and Flu",
"Care One Sinus Congestion and Pain",
"Pressure Plus Pain PE",
"Daytime Cold and Flu relief",
"Day Time Night Time",
"Poly Hist Forte",
"Acetaminophen Sinus Congestion and Pain Daytime",
"Promethazine VC with Codeine",
"Daytime Nitetime Cold and Flu",
"Acetaminophen, Diphenhydramine Hyhrochloride, Phenylephrine Hydrochloride",
"Cold and Cough",
"Promethazine Hydrochloride Phenylephrine Hydrochloride and Codeine Phosphate",
"Sinus Congestion and Pain daytime nighttime",
"Sinus Congestion and Pain daytime nighttime",
"Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hydrobromide, Phenylephrine Hydrochloride",
"Daytime Nitetime Cold and Flu",
"AP-Hist DM",
"Leader Sinus Relief",
"Topcare Sinus Relief Day Time Night Time",
"Topcare Sinus Relief Day Time Night Time",
"Hemorrhoidal Cooling",
"Careone Daytime Severe Cold Flu Relief",
"Sinex",
"Sinex",
"Tussin CF Adult Cough and Cold",
"Preferred Plus Chest Congestion Relief PE",
"Severe Cold and Flu",
"Hemorrhoidal",
"Cold Multi-Symptom Nighttime",
"CVS Health Nighttime Severe Cough and Cold Nighttime Severe Cold and Cough",
"Topcare Cold",
"Leader Sinus Relief",
"Tussin Multi Symptom",
"Leader Childrens Cold and Cough",
"Leader Day Time",
"Daytime Nite Time",
"Leader Sinus Congestion and Pain Daytime Non Drowsy",
"Acetaminophen, Phenylephrine Hydrochloride",
"Cough and Cold XL3 Xtra",
"Rugby Congestion Relief",
"Dr Manzanilla DM",
"Severe Sinus Congestion",
"good sense DayTime Night Time",
"Carbaphen CH",
"Severe Cold and Flu Nighttime Daytime",
"Severe Cold and Flu Nighttime Daytime",
"Triaminic Cold and Allergy",
"Ed A-hist",
"Leader Day Time",
"Harmon Face Values Tussin CF",
"Non Drowsy Cold and Cough PE",
"Equaline hemorrhoidal cooling",
"Carbaphen Ped CH",
"Duravent DM",
"Sinus Relief Congestion and Pain - Daytime and Nighttime",
"Sinus Relief Congestion and Pain - Daytime and Nighttime",
"Night time sinus",
"Head Congestion Daytime and Nighttime Cold",
"Head Congestion Daytime and Nighttime Cold",
"Robitussin Peak Cold Nighttime Multi-symptom Cold",
"Equate Daytime Nitetime",
"Brohist D",
"Healthy Accents Day Time Night Time",
"CareOne Day Time Severe Cold Night Time Cold and Flu",
"CareOne Day Time Severe Cold Night Time Cold and Flu",
"CareOne Daytime Nighttime Cold Flu Relief",
"Sinus Congestion and Pain Daytime Non-Drowsy Severe",
"Cold and Flu Day Night",
"Triaminic Day - Night Club Pack",
"Triaminic Day - Night Club Pack",
"Childrens Mucus Relief",
"Recticare Advanced",
"Sinus Congestion and Pain",
"Maximum Strength Mucus Relief Severe Congestion and Cough",
"ColdaeWon Nose A Syrup",
"Healthy Accents Daytime",
"Adult Cold, Flu and Sore Throat",
"Congestion Relief",
"COMTREX Maximum Strength Cold and Cough Non-Drowsy",
"Sinus Headache PE",
"Acetaminophen, Dextromethorphan Hydrobromide, Phenylephrine Hydrochloride",
"CareOne Sinus Plus Headache",
"CareOne Sinus Plus Headache",
"COMTREX Maximum Strength Day / Night Severe Cold and Sinus",
"COMTREX Maximum Strength Day / Night Severe Cold and Sinus",
"Severe Nighttime Cold and Flu",
"NorelCS CS",
"Acetaminophen, Chlorpheniramine Maleate, Phenylephrine Hydrochloride",
"Guaifenesin Phenylephrine Dextromethorphan",
"Good Sense Tussin CF Cough and Cold",
"Sinus Congestion and Pain Daytime",
"DAYTIME SEVERE COLD and COUGH NIGHTTIME SEVERE COLD and COUGH",
"DAYTIME SEVERE COLD and COUGH NIGHTTIME SEVERE COLD and COUGH",
"Sinus",
"Sinus",
"Daytime Sinus",
"NyQuil Severe Cold and Flu",
"Cold and Flu",
"Care One Cold Mutli Symptom",
"Alka-Seltzer Plus Night Cold Formula (Lemon)",
"Day Relief Night Relief Sinus PE",
"Day Relief Night Relief Sinus PE",
"Allergy Plus Severe Sinus Headache",
"Dg Health Flu and Severe Cold and Cough",
"Mucinex Childrens Cough and Congestion",
"Cold and Flu Daytime/Nightime",
"Equate Daytime Cold and Flu Nighttime Cold and Flu",
"Maximum Strength Mucinex Fast-Max Day Time Cold and Flu and Night Time Cold and Flu",
"Maximum Strength Mucinex Fast-Max Day Time Cold and Flu and Night Time Cold and Flu",
"Cold and Flu Daytime",
"Cold and Flu Daytime",
"Cold and Flu Daytime",
"Cold and Flu Daytime",
"Cold and Flu Daytime",
"Cold and Flu Daytime, Nighttime, Multi-Symptom",
"Mucinex Childrens FreeFrom Multi-Symptom Cold, Flu and Sore Throat and Mucinex Childrens FreeFrom Multi-Symptom Cold and Flu Nighttime",
"Mucinex Childrens FreeFrom Multi-Symptom Cold, Flu and Sore Throat and Mucinex Childrens FreeFrom Multi-Symptom Cold and Flu Nighttime",
"Topcare Cold and Flu Night Time",
"Dr Cocoa Day Night Combo",
"Dr Cocoa Day Night Combo",
"Circle K Daytime Cold and Flu",
"Day Time Night Time Cold and Flu",
"Equate Daytime Nitetime",
"Equate Daytime Nitetime",
"Hemorrhoidal Relief Cream",
"Mucinex FreeFrom Cold and Flu Daytime and Mucinex FreeFrom Cold and Flu Nighttime",
"Mucinex FreeFrom Cold and Flu Daytime and Mucinex FreeFrom Cold and Flu Nighttime",
"Alka-Seltzer Plus Severe Cold PowerFast Fizz Orange Zest",
"Multi-symptom Daytime",
"Severe Nighttime Cold and Flu",
"COLD and FLU DAYTIME MAXIMUM STRENGTH NON-DROWSY SEVERE",
"Maximum Strength Daytime - Nighttime Cold and Flu Cold and Flu",
"Maximum Strength Daytime - Nighttime Cold and Flu Cold and Flu",
"Daytime Cold and Flu Multi Symptom",
"Tukol Cough and Congestion",
"Daytime- Nighttime Cold and Flu",
"Maximum Strength Nighttime Cold and Flu",
"Dg Health Day Time Severe Cold and Flu",
"Signature Care Daytime Severe Cold and Flu Relief",
"Dg Health Night Time Severe Cold and Flu Relief",
"Signature Care Nighttime Severe Cold and Flu Relief",
"Daytime Cold and Flu Non Drowsy",
"Daytime Nighttime Cold Flu Relief",
"Mucinex Childrens FreeFrom Multi-Symptom Cold, Flu and Sore Throat and Mucinex Childrens FreeFrom Multi-Symptom Cold and Flu Nighttime",
"Mucinex Childrens FreeFrom Multi-Symptom Cold, Flu and Sore Throat and Mucinex Childrens FreeFrom Multi-Symptom Cold and Flu Nighttime",
"Equate Vapor Ice Cold and Flu",
"Maxi-Tuss PE Max",
"Maxi-Tuss PE Jr",
"Maxi-Tuss Jr",
"Maxi-Tuss PE",
"Equate Vapor Ice Cold and Flu",
"Severe Vapor Ice Cold and Flu Relief",
"Daytime Liquid Caps",
"Daytime",
"Equate Daytime Nighttime Cold and Flu",
"Equate Daytime Nighttime Cold and Flu",
"Equate daytime severe vaporice cold and flu nighttime severe vapor ice cold and flu",
"Equate daytime severe vaporice cold and flu nighttime severe vapor ice cold and flu",
"Day-night Severe Cold and Flu",
"Day-night Severe Cold and Flu",
"Mucinex Sinus-Max Pressure, Pain and Cough and Mucinex Sinus-Max Severe Congestion Relief Clear and Cool",
"Fast Dissolving Daytime - Nighttime Cold and Flu",
"Fast Dissolving Daytime - Nighttime Cold and Flu",
"Day Maximum Strength Cold and Flu Relief",
"Day Maximum Strength Cold and Flu Relief",
"Hemorrhoidal",
"Cold and Flu Night",
"Head Congestion",
"Cold",
"Maximum Strenth Night Cold and Flu Formula",
"Maximum Strenght Day Cold and Flu Formula",
"Alahist PE",
"Maximum Strength Cold and Flu",
"Maximum Strength Day-night Cold and Flu Formula",
"Maximum Strength Day-night Cold and Flu Formula",
"Sinus and Headache",
"Cold and Flu Severe Night",
"Childrens Dibromm Cold and Allergy",
"Equate Childrens Multi Symptom Cold",
"Tukol Honey Children Cough and Congestion",
"CVS Childrens Cold and Allergy",
"Tukol Honey Daytime Cold and Flu",
"Childrens Multi Symptom Fever and Cold",
"Miclara DM",
"ASP Nighttime Max",
"ASP Daytime PE",
"Maximum Strength Cold Flu and Sore Throat",
"Maximum Strength Nighttime Cold and Flu",
"Kroger Maximum Strength Severe Congestion and Cough",
"Rugby Chest Congestion Relief PE",
"Sinus Severe",
"Allergy Multi Symptom",
"Pressure and Pain",
"SEVERE COLD DAY COLD and FLU NIGHT",
"SEVERE COLD DAY COLD and FLU NIGHT",
"Cold Flu and Sore Throat",
"Sinus Pressure and Pain",
"Cold Plus Head Congestion Severe",
"Allergy Multi symptom",
"Sinus and Headache",
"Mucus Relief Sinus Pressure Pain and Cough",
"Daytime Nighttime Cold and Flu",
"Daytime Nighttime Cold and Flu",
"COLD and FLU SEVERE",
"Pressure and Pain and Cold",
"Cold Max Multi Symptom Nighttime",
"Allergy Relief Plus Sinus Headache",
"Mucus Relief Severe Cold",
"Cold Max",
"Mucus Relief Cold and Flu All In One",
"Allergy Multi Symptom",
"Cold Max Multi Symptom",
"Sinus and Headache",
"Allergy Multi Symptom",
"Sinus and Headache",
"Sinus and Headache",
"Cold Max Multi Symptom Severe",
"Sinus Congestion and Pain",
"Cold Max",
"Cold and Flu Severe",
"Sinus Relief Day Night",
"Sinus Relief Day Night",
"Mucus Relief Sinus Severe Congestion and Pain",
"Sinus Pressure and Pain PE",
"Sinus Pressure plus Pain PE",
"Mucus Relief Cold, Flu and Sore Throat",
"Congestion and Headache",
"Cold and Flu All In One",
"Sinus and Headache Day Night",
"Sinus and Headache Day Night",
"Sinus and Headache Day Night",
"Sinus and Headache Day Night",
"Sinus Sevre",
"Sinus and Headache",
"Sinus plus Headache",
"Allergy Multisymptom",
"Sinus and Headache",
"Cold and Flu Severe",
"Sinus Plus Headache",
"Cold and Flu Severe Daytime",
"Cold and Flu Severe",
"Cold and Flu Severe",
"Mucus Relief Sinus Severe Congestion Relief",
"Cold and Head Congestion Severe",
"Cold and Flu Daytime, Nighttime, Multi-Symptom",
"Daytime Non-Drowsy Cold and Flu",
"Cold and Flu Daytime, Nighttime, Multi-Symptom",
"Tukol Honey Daytime and Nighttime Value Pack",
"Congestion and Headache",
"Childrens Cold and Allergy Relief",
"Severe Cold and Cough Relief Daytime",
"Severe Cold and Cough Nighttime",
"Novalgina Children Cough and Cold",
"Cold and Flu Severe",
"Cold and Flu Relief Daytime/Nighttime",
"Cold and Flu Relief Daytime",
"Tussin CF",
"Hemorrhoidal",
"Good Sense Mucus Relief Cold Flu and Sore Throat",
"Hemorrhoidal",
"Maximum Strength Severe Congestion and Cough",
"Basic Care Daytime",
"Daytime Nighttime Cold and Flu",
"Cold, Flu and Sore Throat Multi-Symptom",
"Severe Cold and Flu Relief Daytime",
"Day and Night Sinus",
"Day and Night Sinus",
"Alka-Seltzer Plus Maximum Strength Day and Night Cold and Flu",
"Alka-Seltzer Plus Maximum Strength Day and Night Cold and Flu",
"Hemorrhoid Relief",
"Cold and Flu Relief",
"Daytime Nighttime Cold and Cough",
"Mucus Relief Cold Flu Sore Throat Maximum Strength",
"Alka Seltzer Plus 2s Blister Pack",
"Alka Seltzer Plus 1s Blister Pack",
"Avedana Hemorrhoidal Maximum Strength",
"Acetaminophen, Chlorpheniramine Maleate, Phenylephrine HCl",
"Acetaminophen, Chlorpheniramine Maleate, Phenylephrine HCl",
"Acetaminophen, Chlorpheniramine Maleate, Phenylephrine HCl",
"Daytime Nighttime Cold and Flu",
"Daytime Cold and Flu",
"Cold and Flu Relief Multi-Symptom, DayTime",
"Daytime Cold and Flu",
"Cold and Flu",
"Maximum Strength Non Drowsy Day and Night Cold and Flu",
"Maximum Strength Non Drowsy Day and Night Cold and Flu",
"Severe Cough and Congestion",
"Mucus Relief cold and flu Daytime/Nighttime",
"Mucus Relief cold and flu Daytime/Nighttime",
"Cold and Flu Daytime, Nighttime",
"Quality Choice Effervescent Cold Relief - Orange",
"Mucus Relief Cold and Flu All in One",
"Mucus Relief Sinus Pressure Pain and Cough",
"Mucus Relief Cold and Flu all in one",
"Mucus Relief Cold Flu and Sore Throat",
"Dr. Butler Hemorrhoid Treatment",
"Mucus Relief Cold and Flu",
"Mucus Relief Cold Flu and Sore Throat",
"Night Time Severe Cold and Flu",
"Hemorrhoid Anesthetic",
"Mucus Relief Cold, Flu and Sore Throat",
"Hemorrhoid Relief",
"Cold and Cough Relief children",
"Lucky SuperSoft Hemorrhoidal",
"Cold and Flu Relief Daytime, Nighttime",
"Hemorrhoid Anesthetic",
"ACETAMINOPHEN, DEXTROMETHORPHAN HBr, GUAILFENESIN,PHENLYEPHRINE HCL",
"Vapor Chill Cold and Flu Daytime/nighttime",
"Vapor Chill Cold and Flu Daytime/nighttime",
"Pentrexcilina Daytime",
"Signature Care Hemorrhoidal Cream (with applicator)",
"Avedana Hemorrhoidal Pain Relief",
"Histenol Forte II",
"Avedana HEMORRHOIDAL COOLING Gel",
"Dilotab II",
"Basic Care Daytime Severe Cold and Flu",
"Cold and Flu Relief Daytime/Nighttime",
"Sinus Relief Severe Congestion and Pain",
"GNP Hemorrhoidal",
"Basic Care Daytime Cold and Flu",
"Basic Care Nighttime Severe Cold and Flu",
"Childrens Cold and Allergy",
"Cold FAid",
"Medique at Home Cold Relief",
"Basic Care Childrens Cold and Cough",
"Ed Bron Gp",
"Glycerin, Lidocaine, Petrolatum, and Phenylephrine Hydrochloride",
"SanaTos Multi Symptom",
"NightTime Cold",
"Daytime Cold and Flu Relief",
"Basic Care Daytime Severe Cold and Flu Nighttime Severe Cold and Flu",
"Basic Care Daytime Severe Cold and Flu Nighttime Severe Cold and Flu",
"Good Sense Severe Daytime Cold and Flu Severe Nighttime Cold and Flu",
"Good Sense Severe Daytime Cold and Flu Severe Nighttime Cold and Flu",
"Walgreen Day Time NightTime Cold and Flu Relief",
"Walgreen Day Time NightTime Cold and Flu Relief",
"Walgreen DayTime Cold and Flu Relief",
"Mucus Relief Sinus",
"Mucus Relief Cold Flu and Sore Throat",
"Walgreen Nighttime Cold and Flu",
"CVS Maximum Strength Cold and Flu Relief",
"Multi-symptom Daytime",
"Acetaminophen, Dextromethorphan Hydrobromide, Phenylephrine Hydrochloride",
"Unishield Cold Relief",
"Acetaminophen, Guaifenesin, Dextromethorphan HBr, Phenylephrine HCl",
"Acetaminophen, Dextromethorphan HBr, Phenylephrine HCl, Doxylamine Succinate",
"Walgreen Day Time Nighttime Cold and Flu Relief Honey Flavor",
"Walgreen Day Time Nighttime Cold and Flu Relief Honey Flavor",
"Hemorrhoidal Relief Cream",
"Sinus Pressure plus Pain",
"Allergy Multisymptom",
"Mucus Relief Cold Flu and Sore Throat",
"Mucus Relief Sinus Pressure Pain and Cough",
"Sinus plus Headache",
"Sinus plus Headache",
"Allergy Multi Symptom",
"Mucus Relief Cold and Flu All in One",
"Sinus Pressure plus Pain PE",
"Mucus Relief Cold Flu and Sore Throat",
"Mucus Relief Sinus Severe Congestion and Pain",
"Mucus Relief Cold and Flu All in One",
"Head Congestion and Mucus",
"Hemorrhoidal Relief Cream",
"Basic Care Tussin CF Severe",
"Promethazine VC",
"Head Congestion and Mucus",
"Sinus Severe",
"Severe Congestion and Cough Relief",
"Promethazine VC with Codeine Oral Solution",
"Xpect Sinus Relief",
"Xpect Cold Relief",
"Basic Care Daytime Severe Cold and Flu Nighttime Severe Cold and Flu",
"Basic Care Daytime Severe Cold and Flu Nighttime Severe Cold and Flu",
"Wal-Phed HEAD CONGESTION AND MUCUS PE",
"Cold and Flu DayTime Relief",
"Daytime Nighttime Cold and Flu Relief Multi-Symptom",
"Sinus Pressure Pain and Cough",
"Daytime Nighttime Severe Cold and Flu Relief",
"Daytime Nighttime Severe Cold and Flu Relief",
"Pain Relief Plus Multi Symptom Cold Childrens",
"Severe Cold and Flu Relief Daytime",
"Severe cold and flu Nighttime",
"Severe Cold and Cough Relief Daytime",
"Mucus Relief Cold, Flu and Sore Throat",
"Head Congestion plus Flu Severe PE",
"Mucus Relief Cold and Flu",
"L-Oral COLD AND FLU RELIEF Syrup",
"Multi-symptom Daytime",
"Daytime Nighttime Cold and Flu Relief Multi-Symptom",
"Multi-symptom Daytime",
"Cold and Flu Severe Daytime/Nighttime",
"Cold and Flu Severe Daytime/Nighttime",
"Clear Eyes Sensitive",
"Cold and Flu Severe Nighttime",
"Cold and Flu Severe Daytime",
"Sinus Max Relief Day and Night",
"Sinus Max Relief Day and Night",
"Non Drowsy Daytime Cold and Flu Softgel",
"Cold and Flu Daytime/Nighttime",
"Toa Syrup Adult",
"Head Congestion and Flu Severe Relief",
"Cold and Flu Relief",
"Sinus Plus Headache",
"Daytime Cold and Flu",
"Cold Multi-Symptom",
"Aramark Fedrin",
"Cold and Flu Daytime",
"Nighttime Severe Cold and Cough",
"Theraflu Multi-symptom Severe Cold",
"Head Congestion and Flu Severe",
"Aspire Day Congestion and Headache Softgel",
"Aspire Night Cold and Flu Softgel",
"Aspire Daytime Mucus and Sinus Softgel",
"Theraflu Nighttime Severe Cold and Cough",
"Maximum Strength Daytime Nighttime Cold and Flu",
"Maximum Strength Daytime Nighttime Cold and Flu",
"Theraflu Multi-Symptom Severe Cold and Theraflu Nighttime Severe Cold and Cough",
"Theraflu Multi-Symptom Severe Cold and Theraflu Nighttime Severe Cold and Cough",
"Theraflu Multi-Symptom Severe Cold and Theraflu Nighttime Severe Cold and Cough",
"Theraflu Multi-Symptom Severe Cold and Theraflu Nighttime Severe Cold and Cough",
"Maximum Strength Daytime Nighttime Sinus Relief",
"Maximum Strength Daytime Nighttime Sinus Relief",
"Sinus Relief Daytime Nighttime",
"Sinus Relief Daytime Nighttime",
"Aramark Multi-Symptom Cold Relief",
"Baczol Expectorant",
"Daytime Cold and Flu Non drowsy",
"Multi-Symptom Cold and Fever Childrens",
"Vicks Formula 44 Cough and Congestion Severe Daytime and Nighttime",
"Vicks Formula 44 Cough and Congestion Severe Daytime and Nighttime",
"Maximum Allergy Relief",
"Vicks DayQuil Cough DM plus Congestion",
"Vicks Formula 44 VapoCool Sever Cough and Congestion",
"Alka-Seltzer Plus Cold Sparkling Original PowerFast Fizz",
"Alka-Seltzer Plus Maximum Strength Sinus Congestion and Pain PowerFast Fizz",
"Childrens Mucus Relief Cough, Cold and Sore Throat",
"Childrens Cough and Cold CF",
"Basic Care Daytime Severe Cold and Flu Nighttime Severe Cold and Flu",
"Basic Care Daytime Severe Cold and Flu Nighttime Severe Cold and Flu",
"Daytime Nighttime Cold and Flu",
"Daytime Nighttime Cold Flu Relief",
"HemorrhoidalOintment",
"Dg Health Day Time Severe Cold and Flu Relief Night Time Severe Cold and Flu Relief",
"Dg Health Day Time Severe Cold and Flu Relief Night Time Severe Cold and Flu Relief",
"Mucus Relief Severe Congestion and Cough Maximum Strength",
"Non-Drowsy Daytime Severe Sinus Congestion and Pain",
"CVS Health Daytime Severe Cold and Flu Relief",
"CVS Daytime and Nighttime Severe Cold and Flu Relief Bundle",
"CVS Daytime and Nighttime Severe Cold and Flu Relief Bundle",
"HemorrhoidalOintment",
"CVS Nighttime Severe Cold and Flu Relief",
"Cold and Flu Daytime/Nightime",
"Non-Drowsy Daytime Severe Cold Multi-Symptom",
"Mucinex Nightshift Sinus Maximum Strength",
"Mucinex Nightshift Severe Cold and Flu Maximum Strength",
"Mucinex Fast-Max Severe Congestion and Cough Arctic Burst Maximum Strength",
"Day Cold and Flu Relief",
"Night Cold and Flu Relief",
"Day-night Cold and Flu",
"Day-night Cold and Flu",
"Cold and Flu Severe, Daytime, Nighttime",
"Cold and Flu Severe, Daytime, Nighttime",
"Mucinex Fast-Max Day Severe Congestion and Cough and Mucinex Nightshift Night Cold and Flu Maximum Strength",
"Mucinex Sinus-Max Day Pressure, Pain and Cough and Mucinex Nightshift Night Sinus Maximum Strength",
"Mucinex Sinus-Max Day Pressure, Pain and Cough and Mucinex Nightshift Night Sinus Maximum Strength",
"Mucinex Fast-Max Day Cold and Flu and Mucinex Nightshift Night Severe Cold and Flu Maximum Strength",
"Mucinex Fast-Max Day Cold and Flu and Mucinex Nightshift Night Severe Cold and Flu Maximum Strength",
"Mucinex Fast-Max Cold and Flu Arctic Burst Maximum Strength",
"Mucinex Nightshift Severe Cold and Flu Arctic Burst",
"Sinus and Allergy Relief PE",
"Daytime Nighttime Cold and Flu",
"Vicks DayQuil Kids Cold Cough plus Mucus",
"Pulmo Calcio",
"Vicks NyQuil Kids Honey Cold Cough Congestion",
"Alka-Seltzer Plus Severe Cold Night PowerFast Fizz",
"Maximum Strength Cold, Flu and Sore Throat",
"Maximum Strength Cold and Flu",
"Basic Care Daytime Nighttime Cold and Flu",
"Tussin",
"Cold and Flu Severe, Day, Night",
"Cold and Flu Severe, Day, Night",
"Top Value Effervescent Cold Relief - Orange",
"DoloMax Cold Cough",
"Sound Body Daytime Cold and Flu Relief Nighttime Cold and Flu Relief",
"Sound Body Daytime Cold and Flu Relief Nighttime Cold and Flu Relief",
"Basic Care Hemorrhoidal",
"Signature Care Childrens Multi Symptom Cold",
"Mucinex Sinus-Max Severe Congestion and Pain Maximum Strength",
"Mucinex Fast-Max Cold, Flu and Sore Throat Maximum Strength",
"Mucinex Fast-Max Congestion and Headache Maximum Strength",
"Mucinex Fast-Max Cold and Flu Maximum Strength",
"Basic Care severe cold and cough",
"Mucinex Sinus-Max Pressure, Pain and Cough Maximum Strength",
"WesTussin DM",
"Basic Care Daytime Severe Cold and Flu",
"Daytime Nighttime Cold Flu Relief",
"Daytime Cold and Flu",
"Up and Up Daytime Multi Symptom Severe Cold Nighttime Severe Cold and Cough",
"Up and Up Daytime Multi Symptom Severe Cold Nighttime Severe Cold and Cough",
"Tukol Max Action Sinus Liquid",
"Alka-Seltzer Plus Severe Cold PowerFast Fizz Day and Night",
"Alka-Seltzer Plus Severe Cold PowerFast Fizz Day and Night",
"Basic Care Daytime Severe Cold and Flu Nighttime Cold and Flu",
"Basic Care Daytime Severe Cold and Flu Nighttime Cold and Flu",
"Basic Care Severe Cold and Flu",
"Basic Care Childrens Mucus Relief",
"Exactuss Total Release",
"GNP Mucus Relief PE",
"COLD, Flu and Sore Throat",
"Maximum Strength Cold and Flu",
"Daytime and Nighttime Sinus Relief",
"Daytime and Nighttime Sinus Relief",
"Maximum Strength Congestion and Headache",
"Severe Congestion Relief",
"Daytime and Nighttime Cold and Flu",
"Daytime and Nighttime Cold and Flu",
"DAYTIME and NIGHTTIME SEVERE COLD AND FLU DAYTIME NON DROWSY NIGHTTIME",
"DAYTIME and NIGHTTIME SEVERE COLD AND FLU DAYTIME NON DROWSY NIGHTTIME",
"Daytime Severe Cold and Flu Relief",
"Non Drowsy DAYTIME and NIGHTTIME Sinus Congestion and Cough Relief",
"Non Drowsy DAYTIME and NIGHTTIME Sinus Congestion and Cough Relief",
"Severe Nighttime Cold and Flu",
"Cold and Flu Daytime, Nighttime, Multi-Symptom",
"SEVERE DAYTIME COLD and FLU DAYTIME MAXIMUM STRENGTH NON-DROWSY SEVERE",
"Daytime Non-Drowsy Cold and Flu",
"Severe Nighttime Cold and Flu",
"SEVERE COLD AND FLU DAYTIME NON DROWSY and NIGHTTIME",
"SEVERE COLD AND FLU DAYTIME NON DROWSY and NIGHTTIME",
"Cold and Flu Daytime, Nighttime, Multi-Symptom",
"SEVERE COLD AND FLU DAYTIME NON DROWSY and NIGHTTIME",
"SEVERE COLD AND FLU DAYTIME NON DROWSY and NIGHTTIME",
"Sinus PE and Allergy",
"DayTime NightTime Cold and Flu Relief",
"Mucus Relief All in One Maximum Strength",
"Mucus Relief All in One Maximum Strength",
"Dimetapp Cold and Cough",
"Multi-symptom Cold and Flu Relief Daytime Nighttime",
"Dimetapp Cold and Cough and Nighttime Cold and Congestion",
"Dimetapp Cold and Cough and Nighttime Cold and Congestion",
"Vicks NyQuil Cough DM plus Congestion",
"Dimetapp Nighttime Cold and Congestion",
"Multi-symptom Cold and Flu Relief Daytime",
"Dimetapp Cold and Cough and Dimetapp Nighttime Cold and Congestion",
"Dimetapp Cold and Cough and Dimetapp Nighttime Cold and Congestion",
"Dimetapp Cold and Allergy",
"Dimetapp Multi-Symptom Cold and Flu",
"Basic Care Daytime Cold and Flu",
"Severe DayTime NightTime Cold and Flu Relief Max Strength",
"Severe DayTime NightTime Cold and Flu Relief Max Strength",
"Cold and Flu maximum strength",
"Suphedrine PE Sinus Pressure Plus Pain",
"Mucus Relief Severe Congestion and Cough Maximum Strength",
"Basic Care Daytime Cold and Flu Nighttime Cold and Flu",
"Basic Care Nighttime Severe Cold and Flu",
"Caring Mill Childrens Cold and Cough",
"Daytime Cold and Flu Nighttime Cold and Flu",
"Daytime Cold and Flu Nighttime Cold and Flu",
"Dometuss-G",
"Caring Mill Childrens Mucus Relief",
"Tylenol Cold Plus Flu Severe",
"Daytime Nighttime Cold and Flu",
"Allergy MultiSymptom",
"Tylenol Cold Plus Flu Severe Day and Tylenol Cold Plus Flu Plus Cough Night 2-pack",
"Tylenol Cold Plus Flu Severe Day and Tylenol Cold Plus Flu Plus Cough Night 2-pack",
"Tylenol Cold Plus Flu Severe Day and Tylenol Cold Plus Flu Plus Cough Night 3-Pack",
"Tylenol Cold Plus Flu Severe Day and Tylenol Cold Plus Flu Plus Cough Night 3-Pack",
"Tylenol Cold plus Flu Severe and Tylenol Cold Max",
"Tylenol Cold plus Flu Severe and Tylenol Cold Max",
"TYLENOL Cold Plus Flu Severe and TYLENOL COLD MAX CoPack",
"TYLENOL Cold Plus Flu Severe and TYLENOL COLD MAX CoPack",
"Polytussin DM",
"Sinus PE Head Congestion and Flu Severe",
"Allergy Relief Plus Congestion",
"Sinex Severe plus Vicks VapoCool",
"Daytime Cold and Flu",
"Daytime Nighttime Cold Flu Relief",
"Vapor Ice Daytime and Nitetime Cold and Flu",
"Vapor Ice Daytime and Nitetime Cold and Flu",
"Allergy Relief",
"sinus pressure and pain PE",
"Allergy Multi Symptom",
"Daytime Nighttime Cold and Flu",
"Daytime Nighttime Cold and Flu",
"Sinus Pressure plus Pain PE",
"Sinus plus Headache",
"Allergy plus Sinus Headache",
"Cold and Cough Childrens",
"Sinus Pressure plus Pain PE",
"Sinus plus Headache Day and Night",
"Sinus plus Headache Day and Night",
"Allergy Multi Symptom",
"Pressure and Pain Plus Mucus PE",
"Mucus Relief Sinus Severe Congestion Relief",
"Sinus Relief Pressure, Pain and Cough",
"Multi Symptom Severe Cold PE",
"Betr Cold and Flu Nighttime Relief",
"Mucus Relief Cold Flu and Sore Throat",
"Pressure and Pain Plus Cough PE",
"Allergy Plus Cold",
"Mucus Relief Cold and Flu All in One",
"Sinus Pressure plus Pain PE",
"Cold and Flu",
"Allergy Plus Sinus Headache",
"Pressure and Pain Plus Cold PE",
"Betr Cold and Flu Daytime Relief",
"Daytime Severe Cold and Flu",
"Novahistex Dh",
"Novahistine Dh",
"Hot Lemon Relief for Symptoms Of Cough and Cold",
"Cough & Cold",
"Cold & Flu",
"Hot Lemon Relief for Symptoms Of Cold and Flu Regular Strength",
"Preparation H-PE Gel",
"Soframycin Nasal Spray",
"Dristan Nasal Mist",
"Dristan Tablets",
"Dimetapp DM Cough & Cold",
"Dimetapp",
"Dimetapp-C",
"Dimetane Expectorant C",
"Coltalin Cold & Allergy Tablets",
"Children's Coltalin Fruit Flavor Chewable Cold Tablets",
"Dimetapp Extra Strength",
"Dimetapp Extra Strength DM Cough & Cold",
"Dilotab II",
"Cold Liquid",
"DM Cough and Cold Liquid",
"Benylin Extra Strength Cold & Sinus Day",
"Benylin Extra Strength Cold & Sinus Plus",
"Nyquil Sinus Liquicaps",
"Dayquil Sinus Liquicaps",
"Regular Strength Tylenol Cold Daytime",
"Regular Strength Tylenol Sinus Daytime",
"Extra Strength Tylenol Flu Daytime",
"Extra Strength Tylenol Sinus Daytime",
"Extra Strength Tylenol Sinus Nighttime",
"Histenol II",
"Extra Strength Tylenol Cold Daytime",
"Nighttime Extra Strength Contac Cold & Sore Throat",
"Extra Strength Contac Complete Cough, Cold & Flu",
"Extra Strength Tylenol Cold Nighttime",
"Extra Strength Contac Cold & Sore Throat",
"Cold & Flu Super Strength",
"Children's Benadryl-D Syrup",
"Daytime Cold/flu Medicine",
"Dayquil Cold & Flu",
"Benylin Extra Strength Cold & Sinus Night",
"Nite Time Cold and Cough",
"Cold & Stuffy Nose",
"Daytime Cough & Cold",
"Runny Nose and Cough",
"Cold Stix Super Strength",
"Robitussin Children's Cold",
"Robitussin Children's Cough & Cold Bedtime",
"Vicks Dayquil Complete Cold & Flu Caplets",
"Vicks Dayquil Complete Cold & Flu Liquid",
"Vicks Nyquil Complete Cold & Flu",
"Jack & Jill Bedtime Cough & Cold",
"Jack & Jill Cough & Cold",
"Neo Citran Extra Strength",
"Neo Citran Nutrasweet",
"Neo Synephrine Nasal Spray",
"Hot Lemon Relief for Cold Symptoms Pws",
"Hot Lemon Relief for Cold Symptoms Ext Str",
"Dimetapp Elixir",
"Dimetapp DM Elixir",
"Dimetapp Extentabs",
"Dimetapp Tab",
"Dimetapp Oral Infant Drops",
"Dimetapp Cold & Sinus",
"Dimetapp DM Tab",
"Dimetane Expectorant-C Syr",
"Dimetane Expectorant-DC Syr",
"Hycomine",
"Citron Chaud DM Option + Pws",
"Citron Chaud Cumberland Pws",
"Citron Chaud DM Cumberland Pws",
"Hycomine-S",
"Dimetane Expectorant Liq",
"Soframycin Nasal Spray",
"Tantapp Elixir",
"Novahistex Dh Expectorant",
"Novahistex C",
"Neo-synephrine Nasal Spray",
"Cold & Allergy Relief - Liq",
"Zincfrin",
"Prefrin A Liq",
"Soframycin Nasal Spray",
"Hot Lemon Regular - Pwr",
"Hot Lemon Extra Strength",
"Cough, Cold & Allergy Relief",
"Neo Tuss Syr",
"Hemorrhoidal Ointment",
"Lemon Time",
"Neo Citran Powder",
"Neo Citran A Powder",
"Dristan Mentholated Nasal Spray",
"Decongestant Antihistaminic Syrup",
"Nasal + Sinus Cold Formula",
"Rhume Et De LA Grippe (extra-fort)",
"Dimetapp Nighttime Cold Tablets",
"Dimetapp Oral Infant Cold Drops",
"Pharmetapp Elixir",
"Dimetapp Oral Infant Cold and Fever Drops",
"Ratio-coristex-DH",
"Oral Infant Cold Drops",
"Little Colds Multi-symptom Cold Formula",
"Little Colds Decongestant Plus Cough",
"Nighttime Regular Strength Contac Cold Nasal Congestion",
"Contac Cold Nasal Congestion",
"Neocitran Thin Strips Nighttime Cough and Cold",
"Neocitran Thin Strips Daytime Cough and Cold",
"Triaminic Toddler Cough and Cold Thin Strips",
"Hemorrhoidal Suppositories",
"Extra Strength Daytime Cold Relief PE",
"Extra Strength Nighttime Cold Relief PE",
"Extra Strength Daytime Flu PE",
"Extra Strength Nighttime Flu PE",
"Hemorrhoidal Suppositories",
"Vasosulf Oph Soln",
"Nezger Tab",
"Coristine-DH Liq",
"Pharmacitron",
"Hot Lemon Relief Powder Extra Strength",
"Expectorant-decongestant Syrup",
"Sudafed PE Head Cold & Sinus",
"Citron Chaud Extra Fort",
"Citron Chaud Réguliern DM",
"Benylin Extra Strength With Menthactin",
"Extra Strength Pharmacitron",
"Cough Syrup DM Decongestant",
"Cough Syrup DM Decongestant for Children",
"Cough Syrup DM-decongestant Expectorant",
"Cough Syrup DM-decongestant-expectorant Extra Strength",
"Sudafed PE Total",
"Cough Syrup DM Decongestant and Expectorant With Acetaminophen",
"Cough Syrup DM Decongestant and Expectorant With Acetaminophen Extra Strength",
"Nighttime Cold Medicine",
"Allergy and Sinus Relief Extra Strength",
"Daytime Sinus Relief Extra Strength Tablet",
"Daytime Cold Relief Extra Strength",
"Fluact",
"Day Time Softgels",
"Nighttime Cold Relief Extra Strength Tablets PE",
"Daytime Cold Relief Extra Strength Tablets PE",
"Allergy + Sinus Relief Extra Strength Tablets PE",
"Daytime Sinus Relief Extra Strength Tablets PE",
"Sinus Medication Day Regular Tablets PE",
"Cold Medication Regular Nighttime Tablets PE",
"Nitetime Cold Relief Extra Strength",
"Grippe Extra Fort Jour",
"Rhume Extra Fort Jour",
"Sinus Extra Fort Jour",
"Grippe Extra Fort Nuit",
"Rhume Extra Fort Nuit",
"Allergie Extra Fort",
"Sinus Extra Fort Nuit",
"Complete One Cold and Flu PE Night",
"Cold Chest Congestion PE Regular Strength",
"Daytime Symptom Relief Extra Strength for Symptoms Of Cold and Cough",
"Hot Liquid Relief for Symptoms Of Flu and Sore Throat",
"Nighttime Symptom Relief Extra Strength for Symptoms Of Cold and Cough",
"Hot Liquid Relief for Symptoms Of Cold and Cough",
"Rapid Action Cold",
"Advil Cold & Sinus PE",
"Flu-away-extra Strength",
"Flu-away-regular Strength",
"Cold Stix-regular Strength",
"Cold Stix-extra Strength",
"DayTime Sinus Relief",
"Nighttime Sinus Relief",
"Flu Multi Symptom Relief",
"Flu Multi Symptom Relief",
"Cold Multi Symptom Relief",
"Cold Multi Symptom Relief",
"Hot Lemon Relief for Symptoms Of Cold and Flu Forte",
"Neocitran Total Cold",
"Extra Strength Multi-symptom Relief Sugar Free",
"Night Time Cold & Flu Liquid",
"Mucinex Sinus-action Complete Congestion and Sinus Pain",
"Cold Stix - Hot Lemon, Sugar-free; Sweetened With Xylitol",
"Mucinex Multi-action Congestion, Stuffy Nose & Cough Liquid",
"Mucinex Multi-action Congestion, Cold & Cough Solution",
"Mucinex Multi-action Cold & Sinus Liquid",
"Mucinex Multi-action Congestion, Cold & Cough",
"Mucinex Multi-action Congestion, Cold & Flu",
"Mucinex Multi-action Congestion & Cold Caplets",
"Nitecap Sinus Liquid Gels",
"Vicks Nyquil Complete Cold & Flu Caplets",
"Daycap Sinus Liquid Gels",
"Regular Strength Tylenol Cold Nighttime",
"Extra Strength Total Symptom Relief Sugar-free",
"Sudafed Total Cold and Flu Rapid Release",
"Sinutab PE Nd Regular Strength",
"Sinutab PE Extra Strength",
"Sinutab PE Nd Extra Strength",
"Benadryl PE Total Regular Strength",
"Benadryl PE Total Extra Strength",
"Actifed PE",
"Benylin All-IN-one Cold and Flu Night PE Caplets",
"Actifed PE Plus",
"Sinutab PE Sinus and Allergy",
"Sudafed PE Cold and Cough",
"Benylin Extra Strength All-IN-one Cold and Flu",
"Tylenol Allergy",
"Tylenol Sinus Nighttime",
"Tylenol Flu Daytime",
"Tylenol Flu Nighttime",
"Extra Strength Tylenol Allergy",
"Sinutab PE Nightime",
"Benylin Extra Strength All-IN-one Cold and Flu Nightime",
"Children's Tylenol Cold and Cough",
"Children's Tylenol Cold and Cough",
"Extra Strength Tylenol Cold and Flu Daytime",
"Tylenol Cold and Flu Nighttime",
"Extra Strength Tylenol Cold and Flu Nighttime",
"Children's Tylenol Cold",
"Children's Tylenol Cold",
"Children's Tylenol Decongestant",
"Junior Strength Tylenol Cold and Cough",
"Benylin DM-D for Children",
"Benylin DM-D",
"Benylin DM-D-E",
"Benadryl Allergy Sinus Headache",
"Benylin All-IN-one Cold and Flu PE Caplets",
"Sudafed PE Cold and Flu Caplets",
"Benylin Cold and Sinus Night Caplets",
"Benylin DM-D Soft Chews With Menthactin",
"Benadryl Allergy Rapid Release",
"Benadryl Allergy & Sinus",
"Extra Strength Tylenol Flu Nighttime",
"Dimetane Expectorant Dc",
"Cold Liquid Grape Flavour",
"DM Cough and Cold Liquid Cherry Flavour",
"DM Cough and Cold Relief",
"Kids Cold Chewable Tablets",
"Cold and Sinus",
"Mucinex Sinus-action Pressure, Pain & Congestion",
"Daycap Cold and Flu Liquid Gels",
"Hemorrhoidal Suppositories",
"Cold Stix",
"Neocitran Extra Strength Total Cold",
"Neocitran Extra Strength Total Cold Night",
"Neocitran Cold & Cough Night",
"Extra Strength Neocitran Flu Syrup",
"Extra Strength Neocitran Total Syrup",
"Tylenol Cold and Flu Daytime",
"Triaminic Daytime Cough & Cold",
"Triaminic Nighttime Cough and Cold",
"Triaminic Chest and Nasal Congestion",
"Extra Strength Neocitran Cold Syrup With Mucus Relief",
"Tylenol Cold Rapid Release",
"Extra Strength Neocitran Total Symptom Relief - Sugar Free",
"Theraflu Nighttime Cold and Flu",
"Theraflu Daytime Cold and Flu",
"Jack & Jill Complete",
"Nighttime Extra Strength Contac Complete Cough, Cold & Flu",
"Hot Lemon for Colds Powder",
"Biohisdex DM Decongestant",
"Biohisdine DM Decongestant",
"Occu-cal Lotion",
"Occu-cal Drops",
"Triaminic Thin Strips Cold & Cough",
"TheraFlu Cold and Flu",
"Neocitran Extra Strength Cold & Congestion",
"Nighttime Extra Strength Contac Complete Cough, Cold & Flu Plus Vitamin C",
"Extra Strength Contac Plus Cold Nasal Congestion",
"Contac Cold & Sinus Extra Strength",
"Contac Cold & Sinus Hot Medicated Drink",
"Extra Strength Contac Cold & Sinus Hot Medicated Drink",
"Super Strength Contac Cold & Sinus Hot Medicated Drink",
"Cold and Flu Relief",
"Neocitran Extra Strength Cold & Sinus Night",
"Dimetapp-C Syr",
"Hot Lemon Relief for Symptoms Of Cold and Flu Extra Strength",
"Extra Strength Cold Liquid",
"Tylenol Sinus Daytime",
"Benylin All-IN-one Cold & Flu Daytime",
"Tylenol Complete Cold, Cough & Flu Nighttime",
"Tylenol Complete Cold, Cough & Flu Daytime",
"Benylin All-IN-one Cold & Flu Nighttime",
"Daytime Complete",
"Sinex Nighttime Sinus",
"Buckley's Complete Cough, Cold & Flu Night",
"Hot Lemon Relief for Symptoms Of Cold and Flu",
"Neocitran Cold & Sore Throat Night",
"Vicks Dayquil Cold & Flu Multi-symptom Relief Liquicaps",
"Odan-vernacon",
"Vicks Sinex Pressure & Pain",
"Phenylephrine/hydroxyethylcellulose",
"Diorouge Liq",
"Pulmorphan",
"Pulmorphan Pediatrique",
"Extra Strength DM Cough and Cold Liquid",
"Neocitran Total Cold Night",
"Neocitran Extra Strength Cold & Sinus Night - Apple Cinnamon",
"Benylin DM-D for Infants",
"Nighttime Complete",
"Diophenyl-T Solution",
"Hot Lemon Relief-extra Strength Pck-pws",
"Hot Lemon Relief Pck-pws",
"Phenyltrope Oph Soln",
"Vicks Custom Care Nasal Congestion/cough",
"Contac Cold Chest Congestion",
"Daytime Cold & Flu Relief",
"Cold Medication Daytime Relief",
"Allergy Sinus Medication",
"Sinus Medication",
"Dristan Extra Strength Caplets",
"Dimetapp Nighttime Cold Extra Strength Caplets",
"Formulation R Hemorrhoidal Ointment",
"Formulation R Hemorrhoidal Suppositories",
"Dimetapp Chewables for Kids",
"Hot Lemon Cough and Cold Relief DM",
"Hot Lemon Cold and Flu Relief Regular Strength",
"Hot Lemon Cold and Flu Relief Extra Strength",
"Daytime Cold & Flu Relief",
"Colds & Coughs",
"Day & Night Combo Pack",
"Apz Hemorrhoidal Suppositories",
"Buckley's Complete Cough, Cold & Flu Day",
"DM Cough and Cold Liquid",
"Cold Liquid",
"Hot Lemon Relief Regular Strength",
"Hot Lemon Relief - Extra Strength",
"Hot Lemon Cough and Colds Relief DM",
"Hot Lemon Relief Powder",
"Cold Syrup",
"Extra Strength Cold Syrup",
"DM Cough and Cold Syrup",
"Extra Strength DM Cough and Cold Syrup",
"Extra Strength Cold Medication Day Time Relief",
"Extra Strength Cold Medication Night Time Relief",
"Robitussin Complete Daytime",
"Buckley's Complete Relief",
"Buckley's Complete Relief",
"Buckley's Complete Relief + Mucus",
"Buckley's Complete Relief + Mucus",
"Triaminic Thin Strips Nighttime Cold & Cough",
"Hot Lemon Relief Regular Strength",
"Hot Lemon Relief Extra Strength",
"Hot Lemon Relief Powder Extra Strength",
"Hot Lemon Relief Powder Regular Strength",
"Dr. Cocoa for Children Nighttime Cough + Cold",
"Dr. Cocoa for Children Daytime Cough + Cold",
"Extra Strength Sinus Congestion and Headache Day Time Relief",
"Dayquil Complete + Vicks Vapocool",
"Nyquil Complete + Vicks Vapocool",
"Nyquil Complete + Vicks Vapocool Cold & Flu Liquid",
"Dayquil Complete + Vicks Vapocool Cold & Flu Liquid",
"Sinex Congestion & Headache",
"Vicks Nyquil Complete Cold & Flu Liquicaps",
"Vicks Dayquil Complete Cold & Flu Liquicaps",
"Xyralid Hemorrhoidal Suppositories",
"Cough & Cold Relief",
"NightTime Cold",
"Total Cold Hot Lemon Relief",
"Total Cold Night",
"Super Strength Cold & Congestion Powder",
"Super Strength Complete Cold Powder",
"Sore Throat & Cold Powder Night",
"Super Strength Sore Throat & Cold Powder",
"Complete Cold & Flu Relief",
"Nighttime Cold & Flu Relief Liquid Gels",
"Total Cold",
"Daytime Cough Cold & Flu Liquid Gels",
"Daycap Cold & Flu Liquid Gels",
"Daycap Sinus Liquid Gels",
"Nitecap Sinus Liquid Gels",
"Hemorrhoidal Ointment",
"Terpacan",
"Hot Lemon Cold and Flu Relief Super Strength",
"Hot Lemon Cold and Flu Relief Regular Strength",
"Hot Lemon Extra Strength Cold & Congestion",
"Hot Lemon Cold & Sore Throat Night",
"Nyquil Complete",
"Dayquil Complete",
"Hot Lemon Total Cold Extra Strength",
"Hot Lemon Extra Strength Cold & Sinus Night",
"Cough and Cold Berry & Green Tea Flavor Extra Strength",
"Novexcold Extra Strength",
"Hot Lemon Extra Strength Total Cold Night",
"Dayquil Cough DM + Congestion",
"Coltalin-ND",
"Daytime Cold",
"Cold Medicine",
"First Aid Shot Therapy Cold Relief",
"4248 First Aid Kit",
"4356 First Aid Kit",
"Mucus Relief Sinus Severe Congestion Relief",
"Good Sense Effervescent Cold Relief",
"Pressure Pain and Cold Suphedrine PE",
"Daytime Severe Cold and Flu",
"Sinus Severe",
"Caring Mill Daytime Cold and Flu",
"Circle K Daytime Cold and Flu",
"Circle K Daytime Cold and Flu",
"Dr. Butler Hemorrhoid Treatment",
"Daytime Cold and Flu",
"Cold Relief",
"Mucinex Fast-Max Day Cold and Flu and Night Cold and Flu Maximum Strength",
"Mucinex Fast-Max Day Cold and Flu and Night Cold and Flu Maximum Strength",
"Mucinex Sinus-Max Day and Night Maximum Strength",
"Mucinex Sinus-Max Day and Night Maximum Strength",
"Vicks NyQuil Severe Honey Cold and Flu",
"Vicks DayQuil Severe Honey Cold and Flu",
"Vicks Formula 44 VapoCool Cough and Chest Congestion",
"Tylenol Sinus Severe",
"Tylenol Sinus Severe",
"Maximum Strength Severe Congestion Relief",
"Tylenol Cold Plus Flu Severe",
"Tylenol Cold Plus Flu Severe",
"Daytime Nighttime Cold and Flu Relief Multi-Symptom",
"DrKids Children Multi Symptom Cold and Flu",
"DrKids Childrens Muti Symptom Cold Flu and Sore Throat Nighttime",
"Nighttime Cold and Flu",
"DrKids Childrens Multi Symptom Cold Cough and Congestion DM",
"SanaTos Turbo Max Strength",
"Daytime Cold and Flu Liquid Gels",
"Actidom Da",
"Sinus PE Congestion",
"Sinus PE Congestion",
"Sinus PE Pressure, Pain and Mucus",
"Sinus PE plus Allergy",
"Preparation H Rapid Relief",
"Drs. pharmacy HEMORRHOIDAL COOLING",
"Cold and Flu Nighttime Severe",
"Basic Care Nighttime Severe Cold and Flu",
"Cold and Flu Daytime Severe",
"Complete Cold Relief",
"Caring Mill Daytime",
"Cvs",
"Daytime Cold and Cough and NightTime Cold and Congestion Childrens",
"Daytime Cold and Cough and NightTime Cold and Congestion Childrens",
"Circle K Cold",
"Covideze",
"CVS Maximum Strength Cold and Flu Relief",
"Tukol Max Action Sinus Caplets",
"Alka-Seltzer Plus Severe Cold and Cough PowerFast Fizz",
"Good Sense Severe Tussin CF Max",
"Sedalmex XL Flu",
"Basic Care Nighttime Severe Cold and Flu",
"Basic Care Daytime Severe Cold and Flu",
"Alka-Seltzer Plus Severe Cold and Flu PowerFast Fizz",
"FLONASE Headache and Allergy Relief",
"Advil Allergy Congestion Relief",
"Advil Sinus Congestion and Pain",
"Tylenol Cold Plus Flu Severe",
"Sinus Pressure, Pain and Cough",
"DayQuil Severe Plus Vicks Vapocool Cold and Flu",
"NyQuil Severe Plus Vicks Vapocool Cold and Flu",
"Sinus plus Headache",
"Antiflu Des Cough and Flu",
"NIGHTTIME Cold and Flu Max Softgels MAXIMUM STRENGTH",
"NON-DROWSY DAYTIME Cold and Flu Max Softgels MAXIMUM STRENGTH",
"Twkof Children",
"Alka-Seltzer Plus Severe Cold PowerFast Fizz Day and Night",
"Alka-Seltzer Plus Severe Cold PowerFast Fizz Day and Night",
"Cold and Flu Relief",
"Theraflu Nighttime Severe Cold and Cough",
"Cold and Flu Relief",
"TheraFlu Cold and Flu",
"AXIM DayTime - Night Time 48 Softgels",
"AXIM DayTime - Night Time 72 Softgels",
"AXIM Sinus Severe Mucus",
"AXIM DayTime",
"Vicks DayQuil Cold and Flu Multi-Symptom Relief",
"Alka Seltzer Plus Severe Cold and Flu PowerFast Fizz",
"Cold and Flu Daytime Nighttime",
"Cold and Flu Daytime Nighttime",
"Basic Care Nighttime Severe Cold and Flu",
"Basic Care Daytime Severe Cold and Flu",
"Theraflu Daytime Severe Cold and Cough",
"SanaTos Multi Symptom",
"Alka-Seltzer Plus Maximum Strength Cold and Cough Power Max Gels",
"Daytime Nighttime Cold and Flu Relief Combo Pack",
"Daytime Nighttime Cold and Flu",
"Severe Congestion, Cough, Cold and Flu Relief Maximum Strength, Nighttime",
"Maximum Strength Mucinex Sinus-Max Severe Congestion and Pain and Mucinex Nightshift Sinus",
"Maximum Strength Mucinex Sinus-Max Severe Congestion and Pain and Mucinex Nightshift Sinus",
"Maximum Strength Mucinex Fast-Max Cold and Flu and Mucinex NightShift Severe Cold and Flu",
"Maximum Strength Mucinex Fast-Max Cold and Flu and Mucinex NightShift Severe Cold and Flu",
"Daytime and Nighttime Cold and Flu Maximum Strength",
"Daytime and Nighttime Cold and Flu Maximum Strength",
"DAYTIME NIGHTTIME SEVERE COLD AND FLU Maximum Strength",
"DAYTIME NIGHTTIME SEVERE COLD AND FLU Maximum Strength",
"Childrens Nighttime Cold and Cough",
"Hemorrhoidal With Lidocaine",
"Daytime Nighttime Sinus Relief Maximum Strength",
"Daytime Nighttime Sinus Relief Maximum Strength",
"Basic Care Hemorrhoidal",
"Nyquil Kids",
"Alka-Seltzer Plus Maximum Strength Sinus, Congestion and Pain Power Max Gels",
"Hemorrhoidal-Ointment",
"Activcin",
"Phenagil",
"Giltuss TR",
"Gilphex",
"Gilphex",
"Giltuss TR",
"Phenagil",
"Phenagil",
"Hemorrhoidal",
"Sunmark Severe Nite Time Cold and Flu",
"Daytime Nighttime",
"Mucinex Childrens Day Time Multi-Symptom Cold and Mucinex Childrens Night Time Multi-Symptom Cold Triple Pack",
"Mucinex Childrens Day Time Multi-Symptom Cold and Mucinex Childrens Night Time Multi-Symptom Cold Triple Pack",
"Daytime",
"Nighttime Cold and Cough childrens",
"Sunmark Severe Day Time",
"DAYTIME COLD AND FLU Maximum Strength",
"NIGHTTIME COLD AND FLU Maximum Strength",
"Alka Seltzer Plus Maximum Strength Sinus, Allergy And Cough Power Max Gels",
"Vicks NyQuil Kids Honey Cold Cough Congestion",
"Tussin CF Max",
"Mucinex Fast-Max Severe Congestion and Cough and Mucinex Nightshift Cold and Flu",
"Tukol Children Cough and Congestion",
"SIMPLE PROMISE Simple H Hemorrhoid Relief Cream",
"Mucinex Fast-Max Cold, Flu and Sore Throat and Mucinex NightShift Cold and Flu",
"Mucinex Fast-Max Cold and Flu and Mucinex NightShift Cold and Flu",
"Maximum Strength Mucinex Fast-Max Cold and Flu and Mucinex NightShift Severe Cold and Flu",
"Maximum Strength Mucinex Fast-Max Cold and Flu and Mucinex NightShift Severe Cold and Flu",
"Diphen",
"Cold Medicine XL3",
"Cold Medicine XL3",
"Tussin CF",
"NightTime Cold and Flu",
"Daytime Cold and Flu",
"Tylenol Cold Plus Flu Severe",
"Tylenol Cold Plus Flu Severe",
"Alka-Seltzer Plus Cold Day and Night PowerMax gels",
"Alka-Seltzer Plus Cold Day and Night PowerMax gels",
"Childrens Night Time Cold and Cough",
"Nighttime Severe Cold and Flu",
"Head Congestion Flu Severe PE",
"Head Congestion Mucus PE",
"Head Congestion Flu Severe PE",
"Cold Max Nighttime",
"Vicks childrens Cough Congestion",
"Head Congestion Mucus PE",
"Allergy Plus Congestion Relief",
"Severe Cold, Cold and Flu Maximum Strength, Daytime, Nightime",
"Severe Cold, Cold and Flu Maximum Strength, Daytime, Nightime",
"Head Congestion Plus Mucus PE",
"Maximum Strength Cold, Flu and Sore Throat",
"Maximum Strength Nighttime Sever Cold and Flu",
"Maximum Strength Daytime Non Drowsy Severe Cold and Flu",
"Head Congestion plus Flu Severe",
"Vicks DayQuil Severe Hot Remedy Cold and Flu plus Congestion",
"Vicks NyQuil Severe Hot Remedy Cold and Flu plus Congestion",
"Vicks NyQuil Severe Hot Remedy Cold and Flu plus Congestion",
"Vicks DayQuil Severe Hot Remedy Cold and Flu plus Congestion",
"Cold Severe Congestion",
"McKesson Sinus Pain and Pressure Relief",
"Algidol Flu",
"Algidol Flu",
"Non-Drowsy Sinus Severe, Circle K",
"Non-Drowsy Sinus Severe, Circle K",
"Daytime Sinus Severe",
"Alka-Seltzer Plus Cold and Flu",
"Cold and Flu Non Drowsy Day Relief and Night Relief",
"Nighttime Severe Cold and Flu",
"Daytime Severe Cold and Flu",
"Equate Health Non Drowsy DAY Cold and Flu Plus and NIGHTTIME Cold and Flu Plus",
"Equate Health Non Drowsy DAY Cold and Flu Plus and NIGHTTIME Cold and Flu Plus",
"Kroger Daytime Cold and Flu Softgel",
"Kroger Daytime and Nighttime Cold and Flu Softgel",
"Daytime Cold and Flu",
"Cold and Flu Non Drowsy Daytime and Nighttime",
"Cold and Flu Relief",
"Walgreens Maximum Strength Non-Drowsy Day and Night Sinus and Cold",
"Walgreens Maximum Strength Non-Drowsy Day and Night Sinus and Cold",
"Walgreens Maximum Strength Non Drowsy Day and Night Cold and Flu",
"Walgreens Maximum Strength Non Drowsy Day and Night Cold and Flu",
"head congestion plus mucus PE",
"head congestion plus flu severe PE",
"Medique Decorel Forte",
"Medi-First Cough Cold",
"Medi-First Plus Cough Cold",
"Multi-Symptom Cold Relief",
"Medique Cold Cough Product",
"Unishield Cough and Cold",
"Medique at Home Decorel Forte",
"Thompson Cough and Cold Multi-Symptom Relief",
"Basic Care Daytime Nighttime Severe Cold and Flu",
"Basic Care Daytime Nighttime Severe Cold and Flu",
"Daytime Nighttime Cold Flu Relief",
"Hemorrhoidalcreamprocure",
"HEMORRHOIDALCREAMPro",
"Vicks Dayquil Hot Remedy",
"Vicks Nyquil Hot Remedy",
"Cold Max",
"Cold plus Head Congestion Severe",
"Sinus Severe",
"Cold plus Flu Severe",
"BranTussin DM",
"Cold and Flu Non Drowsy Daytime and Nighttime",
"Cold and Flu Non Drowsy Daytime and Nighttime",
"Cold and Flu Relief",
"Cold Max Nighttime",
"Head Congestion Plus Flu Severe PE",
"Novalgina Children Cough and Cold",
"Daytime Cold and Flu",
"Daytime, Nighttime Severe Cold and Flu Relief",
"Daytime, Nighttime Severe Cold and Flu Relief",
"Dexchlorpheniramine Maleate, Phenylephrine HCl",
"Ed A-hist",
"Ed-A-hist DM",
"COLDTAC Plus",
"Non Drowsy Severe Daytime and Nighttime Cold and Flu Relief",
"Non Drowsy Severe Daytime and Nighttime Cold and Flu Relief",
"Twkof Adult",
"Cold and Flu Day, Night",
"Cold and Flu Day",
"Walgreen Severe Multi-Symptom Cough Cold Flu",
"Daytime Severe Cold and Flu",
"Daytime Severe Cold and Flu Relief",
"Head Congestion plus Flu Severe PE",
"SECONDARY NUMB Lidocaine Phenylephrine Gel",
"Mucus Relief Sinus Pressure Pain and Cough",
"Mucus Relief Sinus Severe Congestion and Pain",
"Head Congestion plus Flu Severe PE",
"Non-Drowsy Max Cold",
"Daytime Cold and Flu",
"Sinus and Headache",
"Maximum Strength Non Drowsy Daytime Severe Cold and Flu",
"Cold Max",
"Cold plus Head Congestion",
"Multi-symptom Daytime",
"Multi-symptom Daytime",
"Multi-symptom Daytime",
"24/7 Life Cold and Flu DayTime Severe",
"Cold and Flu Nighttime Severe",
"CAREALL Hemorrhoidal",
"Daytime Non Drows Cold and Flu and Nighttime Cold and",
"NyQuil VapoCOOL SEVERE COLD and FLU plus CONGESTION",
"DayQuil VapoCOOL SEVERE COLD and FLU plus CONGESTION",
"Maximum Strength Severe Sinus Pressure, Pain and Cough Relief",
"Dometuss-NR",
"Vicks DayQuil COLD and FLU",
"Vicks DayQuil VapoCOOL SEVERE COLD and FLU plus CONGESTION",
"Mucinex Fast-Max Severe Congestion and Cough Clear and Cool and Maximum Strength Mucinex Nightshift Cold and Flu Clear and Cool",
"Mucinex Fast-Max Severe Congestion and Cough Clear and Cool and Maximum Strength Mucinex Nightshift Cold and Flu Clear and Cool",
"Vicks NyQuil VapoCOOL Severe COLD and FLU plus CONGESTION",
"Severe Congestion and Cough, Cold and Flu Daytime, Nighttime",
"Panadol Cold and Flu NonDrowsy",
"Sinus PE Head Congestion and Mucus",
"Head Congestion plus Mucus PE",
"Tylenol Cold and Flu",
"Tylenol Sinus Severe",
"Alka-seltzer Plus Cold and Flu",
"Dimacol",
"Tukol Max Action Cold, Flu and Sore Throat",
"Pediacare Childrens Cough and Cold Grape",
"Jack & Jill Bedtime Multi-symptom Cold & Cough",
"Numb Squeeze",
"Vicks DayQuil Kids Honey and Vicks NyQuil Kids Honey COLD and COUGH plus",
"Vicks DayQuil Kids Honey and Vicks NyQuil Kids Honey COLD and COUGH plus",
"Vicks Childrens Cough Congestion",
"Vicks Childrens Cough Congestion",
"Tukol Day Time Cold and Flu Relief Softgels",
"Avedana Hemorrhoidal",
"Theraflu Severe Cold Relief Daytime and Theraflu Severe Cold Relief Nighttime",
"Theraflu Severe Cold Relief Daytime and Theraflu Severe Cold Relief Nighttime",
"Tukol Childrens Cold and Flu",
"Good Sense Childrens Cold and Cough",
"Good Sense Childrens Cold and Cough",
"Tylenol Sinus Severe",
"Tylenol Cold Plus Flu Severe",
"CVS Severe Multi-Symptom Cough Cold Flu",
"CVS NightTime Cold",
"CVS Daytime Cold and Flu Relief",
"Severe Cold",
"Novalgina Pediatrico Cough and Cold Pediatrico",
"Leader Tussin CF",
"Always Save Mucus Relief PE",
"Rompe Pecho Nighttime",
"Mucus Relief Cold and Flu Daytime Nighttime",
"Mucus Relief Cold and Flu Daytime Nighttime",
"Hemorrhoidal Cream",
"Multi-symptom Daytime",
"Dr Butlers Hemorrhoid and Fissure PF",
"Daytime Cold and Flu Relief",
"Dayquil Severe Plus Vapocool Cold and Flu",
"Daytime Nighttime Cold Flu Relief",
"Alka-Seltzer Plus Severe Cold and Flu PowerFast Fizz",
"Childrens Dimetapp Cold and Cough",
"CVS Childrens Nighttime Multi Symptom Cold",
"SIMPLE PROMISE Simple H Hemorrhoid Relief Cream",
"RectiBiom Hemorrhoid Relief",
"Handy Solutions Cold Relief",
"Walgreen Daytimel Kids Cold Cough plus Mucus",
"Walgreens Maximum Strength Severe Congestion and Cough",
"Walgreens Nighttime Kids Honey Cold Cough Congestion",
"Rynex PE",
"Alka-Seltzer Plus Severe Cold and Flu PowerFast Fizz",
"Alka-Seltzer Plus Cold and Flu, BASIX",
"Vicks DayQuil NyQuil HOT REMEDY RAPID RELIEF MULTI-SYMPTOM Cold and Flu plus Congestion",
"Vicks DayQuil NyQuil HOT REMEDY RAPID RELIEF MULTI-SYMPTOM Cold and Flu plus Congestion",
"Vicks DayQuil NyQuil HOT REMEDY RAPID RELIEF MULTI-SYMPTOM Cold and Flu plus Congestion",
"Vicks DayQuil NyQuil HOT REMEDY RAPID RELIEF MULTI-SYMPTOM Cold and Flu plus Congestion",
"Vicks NyQuil HOT REMEDY RAPID RELIEF MULTI-SYMPTOM Cold and Flu plus Congestion",
"Vicks NyQuil HOT REMEDY RAPID RELIEF MULTI-SYMPTOM Cold and Flu plus Congestion",
"Vicks DayQuil HOT REMEDY RAPID RELIEF MULTI-SYMPTOM Cold and Flu plus Congestion",
"Vicks DayQuil HOT REMEDY RAPID RELIEF MULTI-SYMPTOM Cold and Flu plus Congestion",
"Alka-Seltzer Plus Cold Day and Night PowerMax gels",
"Alka-Seltzer Plus Cold Day and Night PowerMax gels",
"Daytime Cold and Flu",
"Lidocaine",
"Maximum Strength Non Drowsy Daytime Severe Cold and Flu",
"CVS DayTime and NightTime Value Pack Cold and Flu",
"CVS DayTime and NightTime Value Pack Cold and Flu",
"Leader Childrens Multi Symptom Cold",
"Childrens Cold and Cough",
"Day-Time Cold and Flu Relief",
"Daytime Severe Sinus Congestion and Pain",
"Non Drowsy DAY and NIGHT Multi-Symptom Cold and Flu Formula",
"Non Drowsy DAY and NIGHT Multi-Symptom Cold and Flu Formula",
"Mucus Relief Sinus Pressure Pain and Cough",
"Tussin Severe",
"Good Sense Tussin CF Max",
"Alka-Seltzer Plus Cold and Flu, CVP",
"Foster and Thrive Chest Congestion Relief PE PE",
"Head Congestion plus Mucus PE",
"Head Congestion plus Flu Severe PE",
"Head Congestion plus Flu Severe",
"Cold plus Flu Severe",
"Nyquil Severe Cold Flu",
"Lidocaine",
"Meijer Adult Severe Multi-Symptom Cough Cold Flu",
"Mucinex-Sinus Max Severe Congestion and Pain Clear and Cool and Mucinex Nightshift Sinus Clear and Cool",
"Mucinex-Sinus Max Severe Congestion and Pain Clear and Cool and Mucinex Nightshift Sinus Clear and Cool",
"Sinus Severe",
"Allergy Multi-Symptom",
"Daytime Severe Cold and Cough",
"Cold and Flu Day and Night, Severe",
"Cold and Flu Day and Night, Severe",
"Non Drowsy Daytime and Nighttime Cold and Flu",
"Theraflu Severe Cold Relief Daytime with Honey Ginger Flavor",
"Theraflu Severe Cold Relief Nighttime with Honey Elderberry Flavor",
"TheraCare Hemorrhoidal",
"Walgreen NightTime Cold and Flu relief",
"Daytime Cold and Flu",
"Nyquil Severe Cold Flu",
"Daytime Nighttime Cold Flu Relief",
"DRx Choice Childrens Stuffy Nose and Chest Congestion",
"Childrens Mucus Cough and Congestion Relief",
"Mucus Relief Cough Cold Sore Throat",
"Walgreens Hemorrhoidal Pain Relief",
"Vicks DayQuil and Vicks NyQuil COLD and FLU",
"Dermatool Hemorrhoidal",
"Cold and Flu Relief Daytime",
"DayTime Cold and Flu",
"Alka-Seltzer Plus Severe Cold Night PowerFast Fizz",
"Warrior Rectal Care",
"DayTime and NightTime Cold and Flu",
"Severe Tussin CF",
"Alka-Seltzer Plus Severe Cold Night PowerFast Fizz",
"Topcare Tussin CF Max",
"Dg Health Tussin",
"Childrens Dimetapp Cold and Cough",
"Daytime Non Drows Cold and Flu and Nighttime Cold and",
"Vicks DayQuil Cold and Flu",
"Tussin Severe Cough Cold Flu",
"Alka-Seltzer Plus Severe Cold PowerFast Fizz Day and Night",
"Alka-Seltzer Plus Severe Cold PowerFast Fizz Day and Night",
"Basic Care Tussin CF Severe",
"Vicks DayQuil and Nyquil VapoCOOL Severe COLD and FLU plus CONGESTION",
"Vicks DayQuil and Nyquil VapoCOOL Severe COLD and FLU plus CONGESTION",
"Basic Care Daytime Severe Cold and Flu Nighttime Severe Cold Cough and Flu",
"Basic Care Daytime Severe Cold and Flu Nighttime Severe Cold Cough and Flu",
"Severe Cold and Flu",
"Vicks DayQuil NyQuil Severe Honey Cold and Flu",
"Vicks DayQuil NyQuil Severe Honey Cold and Flu",
"Mydcombi",
"Severe Cold DM",
"Alka-Seltzer Plus Severe Cold PowerFast Fizz Day and Night",
"Alka-Seltzer Plus Severe Cold PowerFast Fizz Day and Night",
"Tussin CF Max",
"Severe Cold DM Severe Cold and Flu",
"Severe Cold DM Severe Cold and Flu",
"Mucinex Fast-Max Kickstart Severe Cold and Flu",
"Polytussin DM",
"Mucinex Night Time Severe Cold and Flu",
"Alahist DM",
"Multi-Symptom Cold childrens",
"MUCINEX FAST MAX Liquid Cold and Flu Kickstart and MUCINEX Nightshift Kickstart",
"MUCINEX FAST MAX Liquid Cold and Flu Kickstart and MUCINEX Nightshift Kickstart",
"Nyquil Severe Cold Flu",
"HemorrhoidalOintment",
"Mucinex Fast-Max Day Cold and Flu and Night Cold and Flu Maximum Strength",
"Mucinex Fast-Max Day Cold and Flu and Night Cold and Flu Maximum Strength",
"Leader Daytime Severe Cold and Flu Relief",
"Daytime Nighttime Severe Cold and Flu Relief",
"Daytime Nighttime Severe Cold and Flu Relief",
"Vicks DayQuil Kids BERRY COLD and COUGH plus MUCUS",
"Mucus DM Fast Max Day Cold and Flu and Night Cold and Flu",
"Mucus DM Fast Max Day Cold and Flu and Night Cold and Flu",
"Daytime Cold and Flu",
"Daytime Nighttime Cold Flu Relief",
"Sinus Pressure, Pain and Cough",
"Severe Cold and Flu Plus Congestion",
"Severe Cold and Flu Plus Congestion",
"Daytime Cold and Flu",
"Pancold A",
"Coldtac Plus Softgels",
"Desresfriol-DX Softgels",
"Omidria",
"Foster and Thrive Daytime Severe Cold and Flu Relief",
"Sinus PE Congestion Daytime Nighttime",
"Sinus PE Congestion Daytime Nighttime",
"Daytime cold and flu",
"Foster and Thrive Nighttime Severe Cold and Flu Relief",
"Daytime Nighttime Cold and Flu",
"Vicks DayQuil ULTRA CONCENTRATED COLD and FLU",
"Dexbrompheniramine-DM-Phenylephrine 2-15-7.5",
"DCH Hemorrhoidal",
"Nighttime Severe Cold and Cough",
"Multi Symptom Severe Cold",
"DayTime Cold and Flu Relief",
"Topcare Nite Time Cold and Flu",
"DCH Rapid Relief Hemorrhoidal",
"Daytime Severe Cold and Flu",
"Good Sense Day Time Cold and Flu",
"WesTussin DM NF",
"Revivol Hemorrhoid and Fissure",
"DayTime Severe Cold and Flu Relief",
"Family Dollar Daytime Cold and Flu Relief",
"Family DollarSevere Nighttime Cold and Flu",
"Daytime Cold and Flu Relief",
"Cold and Flu Daytime Nighttime",
"Day and Night Cold Symptom Relief",
"Day and Night Cold Symptom Relief",
"Cold Multi-Symptom Severe",
"Zensa Anorectal Gel",
"Cough & Congestion",
"Good Neighbor Pharmacy Dye Free Severe Cold Multi-Symptom",
"Sinus Severe",
"Daytime Cold and Flu and Nigttime Cold and Flu",
"CVS DT and NT Combo Pack Cold and Flu",
"Nighttime Severe Cold and Flu",
"Mucus Relief Severe Congestion and Cough",
"CETAFEN COUGH and COLD",
"Good Sense Night Time Cold and Flu",
"DG Health DayTime SEVERE Cold and Flu",
"Mucus Relief Cold, Flu and Sore Throat",
"DG Health NightTime SEVERE Cold and Flu",
"Cold and Flu plus Congestion Daytime",
"Vicks DayQuil NyQuil ULTRA CONCENTRATED COLD and FLU",
"Cold and Flu plus Congestion Nighttime",
"Vicks DayQuil NyQuil BERRY Kids COLD and COUGH plus",
"Tussin CF",
"Daytime Cold and Flu Severe, Caseys 4goog",
"Sinus Relief, Caseys 4good",
"Hemorrhoidal",
"Hemorrhoidal Pain Relief",
"Hemorrhoidal cocoa butter",
"DayQuil and NyQuil VapoCOOL SEVERE COLD and FLU plus CONGESTION",
"DayQuil and NyQuil VapoCOOL SEVERE COLD and FLU plus CONGESTION",
"Sinus Congestion and Pain",
"Up and Up Nighttime Severe Cold and Flu",
"DG Health Cold and Flu Severe",
"Mucinex Fast-Max Cold and Flu Arctic Burst and Nightshift Severe Cold and Flu Arctic Burst",
"Mucinex Fast-Max Cold and Flu Arctic Burst and Nightshift Severe Cold and Flu Arctic Burst",
"Severe Cold and Flu Relief",
"Topcare Day Time Cold and Flu",
"Theraflu Severe Cold relief Nighttime",
"VICKS DayQuil SEVERE HONEY FLAVOR COLD and FLU",
"VICKS NyQuil SEVERE HONEY FLAVOR COLD and FLU",
"Theraflu Severe Cold relief Nighttime",
"Family Dollar Daytime and Nighttime Combo Pack Cold and Flu",
"Vicks DayQuil and Vicks NyQuil Cold and Flu",
"Daytime Severe",
"Equate Cold and Flu",
"Foster and Thrive Childrens Cold and Cough Relief DM",
"Tussin Multi Symptom Cold CF Adult",
"Tussin Multi Symptom Cold CF Adult",
"Rompe Tos X Children",
"Cold and Flu Daytime Severe, 24/7 Life",
"Tenalif Multi Symptom Relief",
"Tenalif Children",
"Rompe Tos X Adults",
"Severe Cold and Flu Relief",
"Cold and Flu Nighttime Severe, 24-7 Life",
"Nighttime Severe",
"Family Wellness Hemorrhoidal",
"First Aid Direct Headache and Congestion Sinus Relief",
"DayQuil Severe plus VapoCOOL Cold and Flu, CVP HEALTH",
"DayQuil Severe plus VapoCOOL Cold and Flu, Travel BASIX",
"Tabcin Extra Strength",
"Equate Nighttime Cold and Flu",
"DG Health Cold and Flu Severe",
"Accu Tuss DM",
"Nyquil Cough DM + Congestion",
"Tylenol Cold Nightime Rapid Release",
"Phenergan Vc Expectorant Syr",
"Phenergan Vc Expectorant W Codeine Liq",
"Daytime Cold Relief Liquid Gels",
"Promethazine Hydrochloride and Phenylephrine Hydrochloride",
"Cold Relief",
"meijer Daytime and Nighttime Cold and Flu SOFTGEL",
"Mucus Fast Max Day Cold and Flu and Night Cold and Flu",
"Mucus Fast Max Day Cold and Flu and Night Cold and Flu",
"Omidria Intraocular Irrigation"
] |
[
"P35348",
"P14416",
"P35368",
"P25100"
] |
[
"P21397",
"P27338",
"P0DMM9",
"P05177"
] |
[] |
[] |
DB00389
|
Carbimazole
|
An imidazole antithyroid agent. Carbimazole is metabolized to methimazole, which is responsible for the antithyroid activity.
|
solid
|
For the treatment of hyperthyroidism and thyrotoxicosis. It is also used to prepare patients for thyroidectomy.
|
Carbimazole is a carbethoxy derivative of methimazole. Its antithyroid action is due to its conversion to methimazole after absorption. It is used to treat hyperthyroidism and thyrotoxicosis.
|
Carbimazole is an aitithyroid agent that decreases the uptake and concentration of inorganic iodine by thyroid, it also reduces the formation of di-iodotyrosine and thyroxine. Once converted to its active form of methimazole, it prevents the thyroid peroxidase enzyme from coupling and iodinating the tyrosine residues on thyroglobulin, hence reducing the production of the thyroid hormones T3 and T4.
| null | null | null | null |
85%
| null | null | null |
Organic compounds
|
Organoheterocyclic compounds
|
Azoles
|
Imidazoles
|
[
"approved",
"investigational"
] |
[
"H03BB",
"H03B",
"H03",
"H"
] |
[
"Humans and other mammals"
] |
[] |
[] |
Athyromazole | Carbethoxymethimazole | Carbimazol | Carbimazole | Carbimazolo | Carbimazolum | Carbinazole | Ethyl 3-methyl-2-thioimidazoline-1-carboxylate | 1.11.1.8 | TPO | 1.14.14.14 | ARO1 | CYAR | CYP19 | CYPXIX | Cytochrome P-450AROM | Cytochrome P450 19A1 | Estrogen synthase
|
[] |
[
"Camen",
"Carbimazol",
"Carbinom",
"Carbizol",
"Neomercazole",
"Neomerdin",
"Newmazole",
"Thyrocab",
"Thyrostat",
"Tyrazol",
"Upha Carbimazole"
] |
[] |
[
"P07202"
] |
[
"P11511"
] |
[] |
[] |
DB00390
|
Digoxin
|
Digoxin is one of the oldest cardiovascular medications used today.[A178225] It is a common agent used to manage atrial fibrillation and the symptoms of heart failure.[A178234] Digoxin is classified as a cardiac glycoside and was initially approved by the FDA in 1954.[L9143]
This drug originates from the foxglove plant, also known as the _Digitalis_ plant[T610], studied by William Withering, an English physician and botanist in the 1780s.[A178237,A178240] Prior to this, a Welsh family, historically referred to as the _Physicians of Myddvai_, formulated drugs from this plant. They were one of the first to prescribe cardiac glycosides, according to ancient literature dating as early as the 1250s.[A178240]
|
solid
|
Digoxin is indicated in the following conditions: 1) For the treatment of mild to moderate heart failure in adult patients.[L9143] 2) To increase myocardial contraction in children diagnosed with heart failure.[L9143] 3) To maintain control ventricular rate in adult patients diagnosed with chronic atrial fibrillation.[L9143]
In adults with heart failure, when it is clinically possible, digoxin should be administered in conjunction with a diuretic and an angiotensin-converting enzyme (ACE) inhibitor for optimum effects.[L9143]
|
Digoxin is a positive inotropic and negative chronotropic drug[A178234], meaning that it increases the force of the heartbeat and decreases the heart rate.[L6253] The decrease in heart rate is particularly useful in cases of atrial fibrillation, a condition characterized by a fast and irregular heartbeat.[A178282] The relief of heart failure symptoms during digoxin therapy has been demonstrated in clinical studies by increased exercise capacity and reduced hospitalization due to heart failure and reduced heart failure-related emergency medical visits.[L9143] Digoxin has a narrow therapeutic window.[L9143]
**A note on cardiovascular risk**
Digoxin poses a risk of rapid ventricular response that can cause ventricular fibrillation in patients with an accessory atrioventricular (AV) pathway. Cardiac arrest as a result of ventricular fibrillation is fatal.[L9143] An increased risk of fatal severe or complete heart block is present in individuals with pre-existing sinus node disease and AV block who take digoxin.[L9143]
|
Digoxin exerts hemodynamic, electrophysiologic, and neurohormonal effects on the cardiovascular system.[A178234] It reversibly inhibits the Na-K ATPase enzyme, leading to various beneficial effects. The Na-K ATPase enzyme functions to maintain the intracellular environment by regulating the entry and exit of sodium, potassium, and calcium (indirectly). Na-K ATPase is also known as the _sodium pump_[L9143]. The inhibition of the sodium pump by digoxin increases intracellular sodium and increases the calcium level in the myocardial cells, causing an increased contractile force of the heart.[L9143,A178264] This improves the left ventricular ejection fraction (EF), an important measure of cardiac function.[A178234,T613]
Digoxin also stimulates the parasympathetic nervous system via the vagus nerve[T607] leading to sinoatrial (SA) and atrioventricular (AV) node effects, decreasing the heart rate.[L9143,A178234] Part of the pathophysiology of heart failure includes neurohormonal activation, leading to an increase in norepinephrine. Digoxin helps to decrease norepinephrine levels through activation of the parasympathetic nervous system.[A178234]
|
Digoxin is approximately 70-80% absorbed in the first part of the small bowel.[A178228] The bioavailability of an oral dose varies from 50-90%, however, oral gelatinized capsules of digoxin are reported to have a bioavailability of 100%.[A178252] Tmax, or the time to reach the maximum concentration of digoxin was measured to be 1.0 h in one clinical study of healthy patients taking 0.25 mg of digoxin with a placebo.[A178369] Cmax, or maximum concentration, was 1.32 ± 0.18 ng/ml−1 in the same study, and AUC (area under the curve) was 12.5 ± 2.38 ng/ml−1.[A178369]
If digoxin is ingested after a meal, absorption is slowed but this does not change the total amount of absorbed drug. If digoxin is taken with meals that are in fiber, absorption may be decreased.[L6274]
**A note on gut bacteria**
An oral dose of digoxin may be transformed into pharmacologically inactive products by bacteria in the colon. Studies have indicated that 10% of patients receiving digoxin tablets will experience the degradation of at least 40% of an ingested dose of digoxin by gut bacteria. Several antibiotics may increase the absorption of digoxin in these patients, due to the elimination of gut bacteria, which normally cause digoxin degradation.[L9143]
**A note on malabsorption**
Patients with malabsorption due to a variety of causes may have a decreased ability to absorb digoxin.[L9143] P-glycoprotein, located on cells in the intestine, may interfere with digoxin pharmacokinetics, as it is a substrate of this efflux transporter. P-glycoprotein can be induced by other drugs, therefore reducing the effects of digoxin by increasing its efflux in the intestine.[L9143]
|
About 13% of a digoxin dose is found to be metabolized in healthy subjects. Several urinary metabolites of digoxin exist, including _dihydrodigoxin_ and _digoxigenin bisdigitoxoside_. Their glucuronidated and sulfated conjugates are thought to be produced through the process of hydrolysis, oxidation, and additionally, conjugation. The cytochrome P-450 system does not play a major role in digoxin metabolism, nor does this drug induce or inhibit the enzymes in this system.[L9143]
|
Oral TDLO (human female): 100 ug/kg, Oral TDLO (human male): 75 ug/kg, Oral LD50 (rat): 28270 ug/kg[MSDS]
Digoxin toxicity can occur in cases of supratherapeutic dose ingestion or as a result of chronic overexposure.[T607] Digoxin toxicity may be manifested by symptoms of nausea, vomiting, visual changes, in addition to arrhythmia. Older age, lower body weight, and decreased renal function or electrolyte abnormalities lead to an increased risk of digoxin toxicity.[L9143]
|
Digoxin has a half-life of 1.5-2 days in healthy subjects.[L9143] The half-life in patients who do not pass urine, usually due to renal failure, is prolonged to 3.5-5 days. Since most of the drug is distributed extravascularly, dialysis and exchange transfusion are not optimal methods for the removal of digoxin.[L9143]
|
Digoxin protein binding is approximately 25%.[L9143] It is mainly bound to albumin.[A178228]
|
The elimination of digoxin is proportional to the total dose, following first order kinetics. After intravenous (IV) administration to healthy subjects, 50-70% of the dose is measured excreted as unchanged digoxin in the urine. Approximately 25 to 28% of digoxin is eliminated outside of the kidney. Biliary excretion appears to be of much less importance than renal excretion.[A178228]
Digoxin is not effectively removed from the body by dialysis, exchange transfusion, or during cardiopulmonary bypass because most of the drug is bound to extravascular tissues.[L9143]
|
This drug is widely distributed in the body, and is known to cross the blood-brain barrier and the placenta.[L9143,A178228] The apparent volume of distribution of digoxin is 475-500 L.[L9143] A large portion of digoxin is distributed in the skeletal muscle followed by the heart and kidneys.[A178228] It is important to note that the elderly population, generally having a decreased muscle mass, may show a lower volume of digoxin distribution.[L9143]
|
The clearance of digoxin closely correlates to creatinine clearance, and does not depend on urinary flow. Individuals with renal impairment or failure may exhibit extensively prolonged half-lives. It is therefore important to titrate the dose accordingly and regularly monitor serum digoxin levels.[L9143] One pharmacokinetic study measured the mean body clearance of intravenous digoxin to be 88 ± 44ml/min/l.73 m².[A178324] Another study provided mean clearance values of 53 ml/min/1.73 m² in men aged 73-81 and 83 ml/min/1.73 m² in men aged 20-33 years old after an intravenous digoxin dose.[A178318]
|
Organic compounds
|
Lipids and lipid-like molecules
|
Steroids and steroid derivatives
|
Steroid lactones
|
[
"approved"
] |
[
"C01AA",
"C01A",
"C01",
"C"
] |
[
"Humans and other mammals"
] |
[
{
"cost": "1.44",
"description": "Lanoxin 0.25 mg/ml ampul",
"unit": "ml"
},
{
"cost": "2.91",
"description": "Digoxin 0.25 mg/ml",
"unit": "ml"
},
{
"cost": "6.79",
"description": "Digoxin Pediatric 0.05 mg/ml",
"unit": "ml"
},
{
"cost": "6.91",
"description": "Lanoxin ped 0.1 mg/ml ampul",
"unit": "ml"
},
{
"cost": "36.99",
"description": "Digoxin 0.05 mg/ml Solution 60ml Bottle",
"unit": "bottle"
},
{
"cost": "450.28",
"description": "Digoxin powder",
"unit": "g"
},
{
"cost": "615.6",
"description": "Digifab 40 mg vial",
"unit": "vial"
},
{
"cost": "727.91",
"description": "Digibind 38 mg vial",
"unit": "vial"
},
{
"cost": "0.22",
"description": "Digoxin 125 mcg tablet",
"unit": "tablet"
},
{
"cost": "0.22",
"description": "Digoxin 250 mcg tablet",
"unit": "tablet"
},
{
"cost": "0.27",
"description": "Toloxin 0.0625 mg Tablet",
"unit": "tablet"
},
{
"cost": "0.27",
"description": "Toloxin 0.125 mg Tablet",
"unit": "tablet"
},
{
"cost": "0.27",
"description": "Toloxin 0.25 mg Tablet",
"unit": "tablet"
},
{
"cost": "0.28",
"description": "Digitek 125 mcg tablet",
"unit": "tablet"
},
{
"cost": "0.28",
"description": "Digitek 250 mcg tablet",
"unit": "tablet"
},
{
"cost": "0.28",
"description": "Lanoxicaps 0.05 mg capsule",
"unit": "capsule"
},
{
"cost": "0.3",
"description": "Lanoxin 125 mcg tablet",
"unit": "tablet"
},
{
"cost": "0.3",
"description": "Lanoxin 250 mcg tablet",
"unit": "tablet"
},
{
"cost": "0.4",
"description": "Lanoxicaps 0.1 mg capsule",
"unit": "capsule"
},
{
"cost": "0.41",
"description": "Lanoxin Pediatric 0.05 mg/ml Elixir",
"unit": "ml"
},
{
"cost": "0.61",
"description": "Digoxin 0.25 mg/ml ampul",
"unit": "ml"
},
{
"cost": "0.62",
"description": "Digoxin 0.25 mg tablet",
"unit": "tablet"
},
{
"cost": "0.64",
"description": "Digoxin 0.125 mg tablet",
"unit": "tablet"
},
{
"cost": "0.66",
"description": "Lanoxin 0.25 mg tablet",
"unit": "tablet"
},
{
"cost": "0.73",
"description": "Lanoxin 0.125 mg tablet",
"unit": "tablet"
}
] |
[] |
12β-hydroxydigitoxin | Digossina | Digoxin | Digoxina | Digoxine | Digoxinum | 7.2.2.13 | KIAA0778 | Na(+)/K(+) ATPase alpha-2 subunit | Sodium pump subunit alpha-2 | 7.2.2.13 | Na(+)/K(+) ATPase alpha-3 subunit | Na(+)/K(+) ATPase alpha(III) subunit | Sodium pump subunit alpha-3 | ATP1B | Sodium/potassium-dependent ATPase subunit beta-1 | Adhesion molecule in glia | AMOG | Sodium/potassium-dependent ATPase subunit beta-2 | ATPB-3 | Sodium/potassium-dependent ATPase subunit beta-3 | OATP-H | OATP-M1 | OATP4C1 | OATPX | Organic anion transporter M1 | Organic anion transporting polypeptide 4C1 | SLC21A20 | SLCO4C1 | Solute carrier family 21 member 20 | 7.2.2.13 | Na(+)/K(+) ATPase alpha-1 subunit | Sodium pump subunit alpha-1 | 1.14.15.6 | Cholesterol desmolase | CYP11A | CYPXIA1 | Cytochrome P450 11A1 | Cytochrome P450(scc) | ATP-binding cassette sub-family B member 1 | MDR1 | Multidrug resistance protein 1 | P-glycoprotein 1 | PGY1 | Phospholipid transporter ABCB1 | OATP-H | OATP-M1 | OATP4C1 | OATPX | Organic anion transporter M1 | Organic anion transporting polypeptide 4C1 | SLC21A20 | SLCO4C1 | Solute carrier family 21 member 20 | 7.6.2.- | ATP-binding cassette sub-family B member 11 | BSEP | OATP | OATP-1 | OATP-A | OATP1 | OATP1A2 | Organic anion-transporting polypeptide 1 | SLC21A3 | Sodium-independent organic anion transporter | Solute carrier family 21 member 3 | OST-alpha | OSTA | Solute carrier family 51 subunit alpha | OST-beta | OSTB | Solute carrier family 51 subunit beta | Liver-specific organic anion transporter 1 | LST-1 | LST1 | OATP-2 | OATP-C | OATP1B1 | OATP2 | OATPC | Organic anion transporter SLC21A6 | SLC21A6 | SLCO1B1 | Sodium-independent organic anion-transporting polypeptide 2 | Solute carrier family 21 member 6
|
[
"Apo-digoxin",
"Apo-digoxin",
"Apo-digoxin",
"Digitek",
"Digitek",
"Digitek",
"Digitek",
"Digox",
"Digox",
"Digox",
"Digox",
"Digox",
"Digox",
"Digox",
"Digox",
"Digox",
"Digox",
"Digox",
"Digox",
"Digox",
"Digox",
"Digox",
"Digox",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin",
"Digoxin Injection C.S.D.",
"Jamp Digoxin",
"Jamp Digoxin",
"Jamp Digoxin",
"Lanoxicaps",
"Lanoxicaps",
"Lanoxicaps",
"Lanoxin",
"Lanoxin",
"Lanoxin",
"Lanoxin",
"Lanoxin",
"Lanoxin",
"Lanoxin",
"Lanoxin",
"Lanoxin",
"Lanoxin",
"Lanoxin",
"Lanoxin",
"Lanoxin",
"Lanoxin",
"Lanoxin",
"Lanoxin",
"Lanoxin",
"Lanoxin",
"Lanoxin",
"Lanoxin",
"Lanoxin",
"Lanoxin",
"Lanoxin",
"Lanoxin",
"Lanoxin",
"Lanoxin",
"Lanoxin",
"Lanoxin",
"Lanoxin",
"Lanoxin",
"Lanoxin",
"Lanoxin",
"Lanoxin",
"Lanoxin",
"Lanoxin",
"Lanoxin",
"Lanoxin",
"Lanoxin Elx 0.05mg/ml Pediatric",
"Lanoxin Inj 0.05mg/ml Pediatric",
"Lanoxin Inj 0.25mg/ml",
"Lanoxin Tab 0.0625mg",
"Lanoxin Tab 0.125mg",
"Lanoxin Tab 0.25mg",
"Novo-digoxin Tab 0.25mg",
"Pediatric Digoxin Injection C.S.D.",
"PMS-digoxin",
"PMS-digoxin",
"PMS-digoxin",
"PMS-digoxin",
"PMS-digoxin",
"PMS-digoxin",
"PMS-digoxin",
"PMS-digoxin",
"PMS-digoxin",
"PMS-digoxin",
"PMS-digoxin",
"Truemed Group LLC"
] |
[
"Agoxin",
"Cardiacin",
"Cardiogoxin",
"Cardioxin",
"Cardoxin",
"Celoxin",
"Centoxin",
"Digacin",
"Digazolan",
"Digocard-G",
"Digoxina",
"Eudigox",
"Lanacordin",
"Lanacrist",
"Lanadicor",
"Lanicor",
"Lenoxin"
] |
[] |
[
"P50993",
"P13637",
"P05026",
"P14415",
"P54709",
"Q6ZQN7",
"P05023"
] |
[
"P05108"
] |
[] |
[
"P08183",
"Q6ZQN7",
"O95342",
"P46721",
"Q86UW1",
"Q86UW2",
"Q9Y6L6"
] |
DB00391
|
Sulpiride
|
Sulpiride first appeared in published literature in 1967.[A229538] Clinical studies show a greater effect on treating the negative symptoms of schizophrenia rather than positive symptoms at low doses, though the effects are more equal at higher doses.[A229683]
Sulpiride is not approved by the FDA, Health Canada, or the EMA; though it is approved in individual European countries.[L24679]
|
solid
|
Sulpiride is indicated for the treatment of acute and chronic schizophrenia.[L31933]
|
Sulpiride is a substituted benzamide derivative and a selective dopamine D2 antagonist indicated to treat acute and chronic schizophrenia.[A229678,A229683,A229688,L31933] It has a short duration of action as it is given twice daily, and a wide therapeutic window as patients have survived single doses as high as 16g.[L31933] Patients should be counselled regarding increased motor agitation, extrapyramidal reactions, and neuroleptic malignant syndrome.[L31933]
|
Sulpiride is a selective dopamine D2 and D3 receptor antagonist.[A229678,A229683,A229688] _In silico_ studies show that sulpiride may interact with the Asp-119 and Phe-417 amino acid residues of these receptors.[A229688] It is estimated that D2 receptors should be 65-80% occupied for optimal treatment and minimal adverse effects.[A229693]
|
Sulpiride has an oral bioavailability of 27 ± 9%.[A229653] A 100-108 mg dose of sulpiride reaches a C<sub>max</sub> of 232-403 ng/mL, with a T<sub>max</sub> of 8.3 h.[A229558] In another study, the AUC of a 100mg oral dose of sulpiride is 1156 ± 522 h\*ng/mL and for an intravenous dose is 3981 ± 813 h\*ng/mL.[A229653]
|
95% of a dose of sulpiride is not metabolized.[A229558]
|
Patients experiencing an overdose of sulpiride may present with hypotension, sinus tachycardia, arrhythmia, dystonia, CNS depression, hallucinations, vomiting, agitation, dysarthria, salivation, as well as increased muscle tone, hyperreflexia, and extensor plantar reflex.[A229658] Patients should be treated with symptomatic and supportive treatment.[A229658]
|
Reports of the half life of sulpiride have only been performed with small numbers of subjects.[A229558,A229653] Therefore, the average half life may be 7.15 hours[A229653] to 8.3 hours.[A229558]
|
Sulpiride is approximately 40% protein bound in plasma, particularly to albumin.[A229568]
|
An intravenous dose of sulpiride is 70 ± 9% eliminated in the urine within 36 hours, while an oral dose is 27 ± 9% eliminated in urine.[A229653] In both cases, the dose is recovered as the unchanged parent compound.[A229653]
|
The average volume of distribution of sulpiride is 2.72 ± 0.66 L/kg.[A229653]
|
The total systemic clearance of sulpiride if 415 ± 84 mL/min, while the mean renal clearance was 310 ± 91 mL/min.[A229653]
|
Organic compounds
|
Benzenoids
|
Benzene and substituted derivatives
|
Benzenesulfonamides
|
[
"approved",
"investigational"
] |
[
"N05AL",
"N05A",
"N05",
"N"
] |
[
"Humans and other mammals"
] |
[] |
[] |
(±)-sulpiride | 5-(Aminosulfonyl)-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxybenzamide | N-((1-Ethyl-2-pyrrolidinyl)methyl)-2-methoxy-5-sulfamoylbenzamide | N-((1-Ethyl-2-pyrrolidinyl)methyl)-5-sulfamoyl-o-anisamide | Sulpirid | Sulpirida | Sulpiride | Sulpiridum | Sulpyrid | Dopamine D2 receptor | Dopamine D3 receptor | 4.2.1.1 | CA-II | CAC | Carbonate dehydratase II | Carbonic anhydrase C | Carbonic anhydrase II | Cyanamide hydratase CA2 | 4.2.1.1 | CA-III | Carbonate dehydratase III | Carbonic anhydrase III | D(2C) dopamine receptor | Dopamine D4 receptor | 3.1.1.8 | Acylcholine acylhydrolase | Butyrylcholine esterase | CHE1 | Choline esterase II | Pseudocholinesterase | hOCT1 | OCT1 | Organic cation transporter 1 | hOCT2 | OCT2 | Organic cation transporter 2 | hMATE-1 | MATE-1 | MATE1 | Solute carrier family 47 member 1 | hMATE-2 | Kidney-specific H(+)/organic cation antiporter | MATE-2 | MATE2 | Solute carrier family 47 member 2 | EMT | EMTH | Extraneuronal monoamine transporter | OCT3 | Organic cation transporter 3 | ATP-binding cassette sub-family B member 1 | MDR1 | Multidrug resistance protein 1 | P-glycoprotein 1 | PGY1 | Phospholipid transporter ABCB1 | 7.6.2.2 | ABCP | ATP-binding cassette sub-family G member 2 | BCRP | BCRP1 | Breast cancer resistance protein | CDw338 | Mitoxantrone resistance-associated protein | MXR | Placenta-specific ATP-binding cassette transporter | Urate exporter
|
[] |
[
"Bosnyl",
"Dogmatil",
"Dogmatyl",
"Dolmatil",
"Eglonyl",
"Espiride",
"Meresa",
"Modal"
] |
[] |
[
"P14416",
"P35462",
"P00918",
"P07451",
"P21917"
] |
[
"P06276"
] |
[
"P02768"
] |
[
"O15245",
"O15244",
"Q96FL8",
"Q86VL8",
"O75751",
"P08183",
"Q9UNQ0"
] |
DB00392
|
Profenamine
|
Profenamine (also known as ethopropazine) is a medication derived from phenothiazine. It is primarily used as an antidyskinetic to treat Parkinsonism. It is sold under the trade name Parsitan in Canada.[L46812] In the US, the marketing of profenamine has been discontinued.[L46817]
|
solid
|
Profenamine is indicated in the symptomatic treatment of drug-induced extrapyramidal reactions and of the manifestations (rigidity, akinesia, sialorrhea, oculogyric crisis, tremor, etc.) of Parkinson's disease of encephalitic, arteriosclerotic or idiopathic origin.[L46812] It is also used to control severe reactions to certain medicines such as reserpine.
|
Profenamine, a phenothiazine and antidyskinetic, is used in the treatment of Parkinson's disease. By improving muscle control and reducing stiffness, this drug permits more normal movements of the body as the disease symptoms are reduced. It is also used to control severe reactions to certain medicines such as reserpine, phenothiazines, chlorprothixene, thiothixene, loxapine, and haloperidol. Unlike other NMDA antagonists, profenamine — because of its anticholinergic action — is largely devoid of neurotoxic side effects. Profenamine also has a slight antihistaminic and local anesthetic effect.
|
Profenamine's anti-Parkinson action can be attributed to its anticholinergic properties. Profenamine partially blocks central (striatal) cholinergic receptors, thereby helping to balance cholinergic and dopaminergic activity in the basal ganglia; salivation may be decreased, and smooth muscle may be relaxed. Drug-induced extrapyramidal symptoms and those due to parkinsonism may be relieved, but tardive dyskinesia is not alleviated and may be aggravated by anticholinergic effects. Profenamine's local anesthetic effect is due to its antagonism of the NMDA glutamate receptor. Glutamate is recognized as an important transmitter in nociceptive pathways, and the N-methyl-D-aspartate (NMDA) subtype of the glutamate receptor, in particular, has been implicated in the mediation of neuropathic pain. Excessive release of glutamate at NMDA receptors on dorsal horn neurons of the spinal cord results in hyperactivation and hypersensitivity of these receptors (perceived as hyperalgesia), thought to be an integral feature of neuropathic pain.
|
Well-absorbed from the gastrointestinal tract.
| null |
Symptoms of overdose include severe clumsiness or unsteadiness, severe drowsiness, severe dryness of mouth, nose, or throat, fast heartbeat, shortness of breath or troubled breathing, and warmth, dryness, and flushing of skin.
|
1 to 2 hours
|
93%
| null | null | null |
Organic compounds
|
Organoheterocyclic compounds
|
Benzothiazines
|
Phenothiazines
|
[
"approved"
] |
[
"N04AA",
"N04A",
"N04",
"N"
] |
[
"Humans and other mammals"
] |
[
{
"cost": "0.23",
"description": "Parsitan 50 mg Tablet",
"unit": "tablet"
}
] |
[] |
10-(2-diethylaminopropyl)phenothiazine | 10-[2-(diethylamino)-1-propyl]phenothiazine | 10-[2-(diethylamino)-2-methylethyl]phenothiazine | 10-[2-(diethylamino)propyl]phenothiazine | 2-diethylamino-1-propyl-N-dibenzoparathiazine | Ethopropazine | N,N-diethyl-1-(10H-phenothiazin-10-yl)-2-propanamine | N,N-diethyl-α-methyl-10H-phenothiazine-10-ethanamine | Profenamina | Profénamine | Profenamine | Profenaminum | H1-R | H1R | HH1R | GluN3A | KIAA1973 | N-methyl-D-aspartate receptor subtype 3A | NMDAR-L | NMDAR3A | NR3A | 3.1.1.8 | Acylcholine acylhydrolase | Butyrylcholine esterase | CHE1 | Choline esterase II | Pseudocholinesterase
|
[
"Parsitan 50"
] |
[
"Dibutil",
"Parkin",
"Parsidol",
"Parsitan"
] |
[] |
[
"P35367",
"P11229",
"Q8TCU5",
"P08172"
] |
[
"P06276"
] |
[] |
[] |
DB00393
|
Nimodipine
|
Nimodipine is a 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, nimodipine prevents calcium-dependent smooth muscle contraction and subsequent vasoconstriction. Compared to other calcium channel blocking agents, nimodipine exhibits greater effects on cerebral circulation than on peripheral circulation. Nimodipine is used to as an adjunct to improve the neurologic outcome following subarachnoid hemorrhage from ruptured intracranial aneurysm.
|
solid
|
For use as an adjunct to improve neurologic outcome following subarachnoid hemorrhage (SAH) from ruptured intracranial berry aneurysms by reducing the incidence and severity of ischemic deficits.
|
Nimodipine belongs to the class of pharmacological agents known as calcium channel blockers. Nimodipine is indicated for the improvement of neurological outcome by reducing the incidence and severity of ischemic deficits in patients with subarachnoid hemorrhage from ruptured congenital aneurysms who are in good neurological condition post-ictus (e.g., Hunt and Hess Grades I-III). The contractile processes of smooth muscle cells are dependent upon calcium ions, which enter these cells during depolarization as slow ionic transmembrane currents. Nimodipine inhibits calcium ion transfer into these cells and thus inhibits contractions of vascular smooth muscle. In animal experiments, nimodipine had a greater effect on cerebral arteries than on arteries elsewhere in the body perhaps because it is highly lipophilic, allowing it to cross the blood brain barrier.
|
Although the precise mechanism of action is not known, nimodipine blocks intracellular influx of calcium through voltage-dependent and receptor-operated slow calcium channels across the membranes of myocardial, vascular smooth muscle, and neuronal cells. By specifically binding to L-type voltage-gated calcium channels, nimodipine inhibits the calcium ion transfer, resulting in the inhibition of vascular smooth muscle contraction. Evidence suggests that the dilation of small cerebral resistance vessels, with a resultant increase in collateral circulation, and/or a direct effect involving the prevention of calcium overload in neurons may be responsible for nimodipine's clinical effect in patients with subarachnoid hemorrhage.
|
In humans, nimodipine is rapidly absorbed after oral administration, and peak concentrations are generally attained within one hour. Bioavailability is 100% following intravenous administration and 3-30% following oral administration due to extensive first-pass metabolism.
|
Hepatic metabolism via CYP 3A4.
|
Symptoms of overdosage would be expected to be related to cardiovascular effects such as excessive peripheral vasodilation with marked systemic hypotension.
|
1.7-9 hours
|
95% bound to plasma protein
|
Nimodipine is eliminated almost exclusively in the form of metabolites and less than 1% is recovered in the urine as unchanged drug. Numerous metabolites, all of which are either inactive or considerably less active than the parent compound, have been identified.
| null | null |
Organic compounds
|
Organoheterocyclic compounds
|
Pyridines and derivatives
|
Hydropyridines
|
[
"approved",
"investigational"
] |
[
"C08CA",
"C08C",
"C08",
"C"
] |
[
"Humans and other mammals"
] |
[
{
"cost": "9.69",
"description": "Nimodipine 30 mg capsule",
"unit": "capsule"
},
{
"cost": "9.87",
"description": "Nimotop 30 mg capsule",
"unit": "capsule"
},
{
"cost": "952.07",
"description": "NiMODipine 100 30 mg capsule Box",
"unit": "box"
}
] |
[
{
"approved": "2019-07-09",
"country": "United States",
"expires": "2038-04-16",
"number": "10342787"
},
{
"approved": "2020-03-03",
"country": "United States",
"expires": "2038-04-16",
"number": "10576070"
},
{
"approved": "2006-07-04",
"country": "United States",
"expires": "2023-06-23",
"number": "7070581"
},
{
"approved": "2013-08-27",
"country": "United States",
"expires": "2024-05-14",
"number": "8517997"
},
{
"approved": "2021-12-28",
"country": "United States",
"expires": "2038-04-16",
"number": "11207306"
},
{
"approved": "2018-04-16",
"country": "United States",
"expires": "2038-04-16",
"number": "11413277"
},
{
"approved": "2018-04-16",
"country": "United States",
"expires": "2038-04-16",
"number": "11517563"
},
{
"approved": "2018-04-16",
"country": "United States",
"expires": "2038-04-16",
"number": "11759457"
},
{
"approved": "2018-04-16",
"country": "United States",
"expires": "2038-04-16",
"number": "11806338"
}
] |
2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-β-methoxyethyl ester 5-isopropyl ester | isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate | isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate | Nimodipine | Nimodipino | Nimodipinum | CACH2 | CACN2 | CACNL1A1 | Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle | CCHL1A1 | Voltage-gated calcium channel subunit alpha Cav1.2 | CACH3 | CACN4 | CACNL1A2 | Calcium channel, L type, alpha-1 polypeptide, isoform 2 | CCHL1A2 | Voltage-gated calcium channel subunit alpha Cav1.3 | CACNAF1 | Voltage-gated calcium channel subunit alpha Cav1.4 | CACH1 | CACN1 | CACNL1A3 | Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle | Voltage-gated calcium channel subunit alpha Cav1.1 | CAB1 | CACNLB1 | Calcium channel voltage-dependent subunit beta 1 | CAB2 | CACNLB2 | Calcium channel voltage-dependent subunit beta 2 | Lambert-Eaton myasthenic syndrome antigen B | MYSB | CAB3 | CACNLB3 | Calcium channel voltage-dependent subunit beta 3 | CAB4 | CACNLB4 | Calcium channel voltage-dependent subunit beta 4 | MCR | MLR | MR | Nuclear receptor subfamily 3 group C member 2 | Ah receptor | AhR | BHLHE76 | Class E basic helix-loop-helix protein 76 | 1,4-cineole 2-exo-monooxygenase | 1,8-cineole 2-exo-monooxygenase | 1.14.14.1 | Albendazole monooxygenase (sulfoxide-forming) | Albendazole sulfoxidase | Cholesterol 25-hydroxylase | CYP3A3 | CYPIIIA3 | CYPIIIA4 | Cytochrome P450 3A3 | Cytochrome P450 HLp | Cytochrome P450 NF-25 | Cytochrome P450-PCN1 | Nifedipine oxidase | Quinine 3-monooxygenase
|
[
"Nimodipine",
"Nimodipine",
"Nimodipine",
"Nimodipine",
"Nimodipine",
"Nimodipine",
"Nimodipine",
"Nimodipine",
"Nimodipine",
"Nimodipine",
"Nimodipine",
"Nimodipine",
"Nimodipine",
"Nimodipine",
"Nimotop",
"Nimotop",
"Nimotop - Cap 30mg",
"Nimotop Cap 30mg",
"Nimotop I.V.-0.2mg/ml",
"Nimotop IV 0.2mg/ml",
"Nymalize",
"Nymalize",
"Nymalize",
"Nymalize"
] |
[
"Periplum"
] |
[] |
[
"Q13936",
"Q01668",
"O60840",
"Q13698",
"Q02641",
"Q08289",
"P54284",
"O00305",
"P08235",
"P35869"
] |
[
"P08684"
] |
[] |
[] |
DB00394
|
Beclomethasone dipropionate
|
Beclomethasone dipropionate is a second-generation[A179842] synthetic corticosteroid and diester of beclomethasone, which is structurally similar to [dexamethasone].[L6871] It is a prodrug of an active metabolite beclomethasone 17-monopropionate (17-BMP)[A179839] which acts on the glucocorticoid receptor to mediates its therapeutic action. Beclomethasone dipropionate itself posesses weak glucocorticoid receptor binding affinity and is rapidly converted into 17-BMP upon administration.[A179839] Formulations for oral inhalation, intranasal, and topical use are available for beclomethasone dipropionate. Beclomethasone dipropionate became first available in a pressurized metered-dose inhaler in 1972 and later in a dry powder inhaler and an aqueous nasal spray.[A179839] Due to its anti-inflammatory, antipruritic, and anti-allergy properties, beclomethasone dipropionate is used in various inflammatory conditions, such as asthma, allergic rhinitis, and dermatoses to reduce symptoms. When inhaled, it is proposed that beclomethasone dipropionate remains active locally in the lung without causing significant side effects associated with systemic corticosteroids.[A180010] Compared to earlier corticosteroids such as [dexamethasone] and [prednisolone], beclomethasone dipropionate is reported to be less irritating to the nasal mucosa with a longer duration of action when administered intranasally.[A179848]
|
solid
|
Indicated for oral inhalation use in the maintenance treatment of asthma as prophylactic therapy in patients 5 years of age and older. The aerosol form of beclomethasone diproprionate is not indicated for the relief of acute bronchospasm.[L6871]
Indicated for intranasal use to relieve the symptoms of seasonal or perennial allergic and nonallergic (vasomotor) rhinitis and prevent the recurrence of nasal polyps following surgical removal.[L6880]
Indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses in patients 13 years of age and older.[L10782] Corticosteroid-responsive dermatoses include psoriasis, contact dermatitis (dermatitis venenata), atopic dermatitis (infantile eczema, allergic dermatitis), neurodermatitis (lichen simplex chronicus, lichen planus, eczema, eczematous dermatitis), intertrigo, dyshidroses (pompholyx), seborrheic dermatitis, exfoliative dermatitis, solar dermatitis, stasis dermatitis, and anogenital and senile pruritus.[L6886]
|
Inflammatory conditions, including asthma, dermatoses, and allergic rhinitis, involve the activation of cascades by inflammatory mediators. Inflammation is a primary defense mechanism and the homeostatic response of the immune system; however, a prolonged inflammatory response in certain disorders may lead to tissue damage, pain, and swelling. Beclomethasone dipropionate works by attenuating the inflammatory responses associated with asthma, allergic rhinitis, nasal polyps, and corticosteroid-responsive dermatoses. It suppresses the actions of inflammatory cells, such as mast cells, eosinophils, basophils, lymphocytes, macrophages, and neutrophils. It also inhibits the release of inflammatory mediators, such as histamine, eicosanoids, leukotrienes, and cytokines.[L6871] Beclomethasone dipropionate is reported to exhibit potent topical activity while possessing low systemic effects.[A179845]
Beclomethasone dipropionate is a corticosteroid drug with anti-inflammatory and vasoconstrictive effects used to treat chronic inflammatory processes such as asthma, allergic rhinitis, corticosteroid-responsive dermatoses. When inhaled, it improves lung function, decreases airway hyper-reactivity, and reduces the severity of asthmatic symptoms.[A180160] Although inhaled corticosteroids, including beclomethasone dipropionate, are reported to mainly act locally in the lungs, systemic effects such as disruption of hypothalamic-pituitary-adrenal (HPA) axis function, bone turnover, osteoporosis, and growth suppression may still be observed with chronic use or high dose administration. There were varying findings from clinical studies examining the effect of beclomethasone dipropionate on growth suppression in pediatric patients.[A180160] It was shown to suppress the hypothalamo-pituitary-adrenal (HPA) axis in a dose-dependent manner.[A179917] HPA axis is a central hormonal response system to stress and activation of HPA axis leads to the production of endogenous steroid hormone production.[A179920] Long-term use of high-dose systemic corticosteroids, including those inhaled, was often associated with signs and symptoms of adrenal insufficiency when exposed to stress conditions, such as trauma, surgery, or infections. As corticosteroids work by suppressing the immune system, there may be an increased risk for developing infections.[L6871] Cases of _Candida albicans_ infection of the mouth and throat have been reported with inhaled beclomethasone dipropionate therapy.[A180010]
|
Beclomethasone dipropionate is a corticosteroid and prodrug that is rapidly activated by hydrolysis to the active monoester, 17 monopropionate (17-BMP), which mediates anti-inflammatory actions. 17-BMP has been shown _in vitro_ to exhibit a binding affinity for the human glucocorticoid receptor which is approximately 13 times that of dexamethasone and 25 times that of beclomethasone dipropionate.[L6871] Upon binding of the ligand, the glucocorticoid receptors dimerize and translocate into the nucleus, where they subsequently bind to glucocorticoid response elements (GRE) on glucocorticoid-responsive genes, leading to changes in transcription. There are several proposed mechanisms for the anti-inflammatory action of corticosteroids. Corticosteroids may work by increasing the transcription of genes coding for anti-inflammatory proteins, including lipocortin-1 and interleukin-10.[A179875] Corticosteroids were also shown to inhibit the expression of multiple genes that encode pro-inflammatory factors, such as cytokines, chemokines, and adhesion molecules, that are activated during the chronic inflammatory process.[A31449] This is thought to be due to the direct inhibitory interaction between activated glucocorticoid receptors and activated pro-inflammatory transcription factors, such as nuclear factor-kappa B and activator protein-1.[A179875] Chronic inflammation is often characterized by enhanced expression of these transcription factors that bind to and activate coactivator molecules, which then acetylate core histones to switch on gene transcription to further amplify the inflammatory process.[A31449] Corticosteroids suppress the multiple inflammatory gene expression by promoting histone deacetylation, resulting in tighter coiling of DNA and reduced access of transcription factors to their binding sites.[A179875]
|
Following oral inhalation of 320 mcg of beclomethasone dipropionate (BDP), the Cmax was 88 pg/mL and it was reached after 0.5 at post-administration. The mean Cmax of the major and most active metabolite, beclomethasone-17-monopropionate (17-BMP), was 1419 pg/mL at 0.7 hour post-dosing.[L6871]
In another pharmacokinetic study, the AUC of BDP and 17-BMP were 6660 and 6185 pgxh/mL, respectively. The Cmax was 35356 pg/mL for BDP and 2633 pg/mL for 17-BMP, and and the median time to reach these concentrations (Tmax) was 0.2 hours. In the same study, the AUC of 17-BMP following oral and intranasal administration were 10158 and 3660 pgxh/mL, respectively. The Cmax of 17-BMP following oral and intranasal administration were 703 and 310 pg/mL, respectively, and the Tmax was 4 hours. The total bioavailability of 17-BMP following oral and intranasal administration were 41% and 44%, respectively.[A179839]
|
During absorption, beclomethasone dipropionate is undergoes rapid and extensive hydrolysis mediated by esterases CYP3A to form beclomethasone-17-monopropionate (17-BMP), beclomethasone-21-monopropionate (21-BMP), and beclomethasone (BOH). 17-BMP is the major active metabolite with the most potent anti-inflammatory activity.[L6871] About 95% of the total beclomethasone dipropionate administered via oral inhalation undergoes presystemic conversion to form 17-BMP in the lung.[A179839]
|
The oral LD<sub>50</sub> in rats is >3750 mg/kg.[MSDS]
The acute toxicity of beclometasone dipropionate is low. The only harmful effect that follows inhalation of large amounts of the drug over a short period of time is suppression of hypothalamic-pituitary-adrenal (HPA) function. Chronic: The excessive use of beclometasone dipropionate over a long period could lead to adrenal suppression.
|
Following intravenous administration, the half life of beclomethasone dipropionate was 0.5 hours while the half life of the active metabolite 17-BMP was 2.7 hours. Following oral and intranasal administration, the half life of 17-BMP was 8.8 and 5.7 hours, respectively.[A179839]
|
Based on the findings of _in vitro_ studies, the protein binding of the main active metabolite, beclomethasone-17-monopropionate (17-BMP), was 94-96% over the concentration range of 1000 to 5000 pg/mL.[L6871]
|
Regardless of the route of administration, beclomethasone dipropionate and its metabolites are predominantly excreted in the feces, with less than 10% of the drug and its metabolites being excreted in the urine.[L6871]
[L6880]
|
Following intravenous administration, the steady-state volume of distribution was 20 L for beclomethasone dipropionate and 424 L for the active metabolite, beclomethasone-17-monopropionate.[A179839]
|
Following intravenous administration, the clearance of beclomethasone dipropionate and 17-BMP were 150 L/h and 120 L/h, respectively.[A179839]
|
Organic compounds
|
Lipids and lipid-like molecules
|
Steroids and steroid derivatives
|
Pregnane steroids
|
[
"approved",
"investigational"
] |
[
"D07CC",
"D07C",
"D07",
"D",
"R03AL",
"R03A",
"R03",
"R",
"R03BA",
"R03B",
"R03",
"R",
"D07AC",
"D07A",
"D07",
"D",
"R03AK",
"R03A",
"R03",
"R",
"R03AK",
"R03A",
"R03",
"R",
"R01AD",
"R01A",
"R01",
"R",
"A07EA",
"A07E",
"A07",
"A"
] |
[
"Humans and other mammals"
] |
[
{
"cost": "15.12",
"description": "Qvar 40 mcg inhaler",
"unit": "g"
},
{
"cost": "19.05",
"description": "Qvar 80 mcg inhaler",
"unit": "g"
},
{
"cost": "87.5",
"description": "Qvar 40 mcg/act Aerosol 7.3 gm Inhaler",
"unit": "inhaler"
},
{
"cost": "105.64",
"description": "Qvar 80 mcg/act Aerosol 7.3 gm Inhaler",
"unit": "inhaler"
},
{
"cost": "107.1",
"description": "Beclomethasone dipro powder",
"unit": "g"
},
{
"cost": "149.32",
"description": "Beconase AQ 42 mcg/spray Suspension 25 gm Inhaler",
"unit": "inhaler"
},
{
"cost": "0.06",
"description": "Apo-Beclomethasone 50 mcg/dose Metered Dose Spray",
"unit": "dose"
},
{
"cost": "0.06",
"description": "Mylan-Beclo Aq. 50 mcg/dose Metered Dose Spray",
"unit": "dose"
},
{
"cost": "0.06",
"description": "Nu-Beclomethasone 50 mcg/dose Metered Dose Spray",
"unit": "dose"
},
{
"cost": "0.16",
"description": "Qvar Cfc-Free 50 mcg/dose Metered Dose Aerosol",
"unit": "dose"
},
{
"cost": "0.33",
"description": "Qvar Cfc-Free 100 mcg/dose Metered Dose Aerosol",
"unit": "dose"
},
{
"cost": "0.46",
"description": "Propaderm 250 mcg/g Cream",
"unit": "g"
}
] |
[
{
"approved": "1998-07-07",
"country": "United States",
"expires": "2015-07-07",
"number": "5776432"
},
{
"approved": "2002-09-10",
"country": "United States",
"expires": "2017-12-18",
"number": "6446627"
},
{
"approved": "2010-08-24",
"country": "United States",
"expires": "2027-01-24",
"number": "7780038"
},
{
"approved": "2016-10-11",
"country": "United States",
"expires": "2031-05-18",
"number": "9463289"
},
{
"approved": "2012-03-13",
"country": "United States",
"expires": "2028-09-07",
"number": "8132712"
},
{
"approved": "2015-01-13",
"country": "United States",
"expires": "2031-07-17",
"number": "8931476"
},
{
"approved": "2009-12-29",
"country": "United States",
"expires": "2020-08-25",
"number": "7637260"
},
{
"approved": "2017-11-07",
"country": "United States",
"expires": "2031-05-18",
"number": "9808587"
},
{
"approved": "2018-07-17",
"country": "United States",
"expires": "2031-11-18",
"number": "10022510"
},
{
"approved": "2018-07-17",
"country": "United States",
"expires": "2031-05-18",
"number": "10022509"
},
{
"approved": "2018-10-02",
"country": "United States",
"expires": "2031-05-18",
"number": "10086156"
},
{
"approved": "2019-01-29",
"country": "United States",
"expires": "2031-10-21",
"number": "10188811"
},
{
"approved": "2020-02-18",
"country": "United States",
"expires": "2032-07-01",
"number": "10561808"
},
{
"approved": "2020-06-30",
"country": "United States",
"expires": "2031-05-18",
"number": "10695512"
},
{
"approved": "2020-10-06",
"country": "United States",
"expires": "2039-01-25",
"number": "10792447"
},
{
"approved": "2011-05-18",
"country": "United States",
"expires": "2031-05-18",
"number": "11395889"
},
{
"approved": "2018-01-26",
"country": "United States",
"expires": "2038-01-26",
"number": "11395888"
},
{
"approved": "2019-07-21",
"country": "United States",
"expires": "2039-07-21",
"number": "11559637"
},
{
"approved": "2021-08-19",
"country": "United States",
"expires": "2041-08-19",
"number": "11583643"
},
{
"approved": "2018-01-26",
"country": "United States",
"expires": "2038-01-26",
"number": "11793953"
},
{
"approved": "2018-01-26",
"country": "United States",
"expires": "2038-01-26",
"number": "11865247"
},
{
"approved": "2018-01-26",
"country": "United States",
"expires": "2038-01-26",
"number": "11896759"
},
{
"approved": "2021-05-05",
"country": "United States",
"expires": "2041-05-05",
"number": "11957832"
}
] |
(11β,16β)-9-chloro-11-hydroxy-16-methyl-17,21-bis(1-oxopropoxy)pregna-1,4-diene-3,20-dione | 9-chloro-11β-hydroxy-16β-methylpregna-1,4-diene-3,20-dione 17,21-dipropionate | 9-chloro-16β-methyl-11β,17,21-trihydroxypregna-1,4-diene-3,20-dione 17,21-dipropionate | beclometasone 17,21-dipropionate | Beclometasone dipropionate | Beclometasone dipropionate anhydrous | Beclometasone dipropionato | Beclomethasone dipropionate | GR | GRL | Nuclear receptor subfamily 3 group C member 1 | 1.14.14.1 | CYPIIIA5 | Cytochrome P450-PCN3 | 1,4-cineole 2-exo-monooxygenase | 1,8-cineole 2-exo-monooxygenase | 1.14.14.1 | Albendazole monooxygenase (sulfoxide-forming) | Albendazole sulfoxidase | Cholesterol 25-hydroxylase | CYP3A3 | CYPIIIA3 | CYPIIIA4 | Cytochrome P450 3A3 | Cytochrome P450 HLp | Cytochrome P450 NF-25 | Cytochrome P450-PCN1 | Nifedipine oxidase | Quinine 3-monooxygenase | CBG | Serpin A6 | Transcortin | ATP-binding cassette sub-family B member 1 | MDR1 | Multidrug resistance protein 1 | P-glycoprotein 1 | PGY1 | Phospholipid transporter ABCB1 | 7.6.2.2 | ABCP | ATP-binding cassette sub-family G member 2 | BCRP | BCRP1 | Breast cancer resistance protein | CDw338 | Mitoxantrone resistance-associated protein | MXR | Placenta-specific ATP-binding cassette transporter | Urate exporter | Liver-specific organic anion transporter 1 | LST-1 | LST1 | OATP-2 | OATP-C | OATP1B1 | OATP2 | OATPC | Organic anion transporter SLC21A6 | SLC21A6 | SLCO1B1 | Sodium-independent organic anion-transporting polypeptide 2 | Solute carrier family 21 member 6 | Liver-specific organic anion transporter 2 | LST-2 | LST2 | OATP-8 | OATP1B3 | OATP8 | Organic anion transporter 8 | Organic anion-transporting polypeptide 8 | SLC21A8 | Solute carrier family 21 member 8
|
[
"Alti-beclomethasone Dipropionate Inhaler 50mcg/md",
"Apo-beclomethasone Nasal Spray",
"Beclodisk - Pwr Inh 100mcg/blister",
"Beclodisk - Pwr Inh 200mcg/blister",
"Beclodisk Pwr 100mcg/blister",
"Beclodisk Pwr 200mcg/blister",
"Becloforte 250mcg/aem",
"Becloforte Inhaler - Aem Inh 250mcg/aem",
"Beclomethasone Aqueous Nasal Spray 50mcg/metered Dose",
"Beclomethasone Dipropionate Nas-spr 50mcg/aem",
"Beclomethasone Dipropionate Nasal Inhaler",
"Beclomethasone Dipropionate Oral Inhaler",
"Beclomethasone Nasal Spray",
"Beclovent - Aem 50mcg/aem",
"Beclovent Aem 50mcg/aem",
"Beclovent Rotacaps - Inh 100mcg/capsule",
"Beclovent Rotacaps - Inh 200mcg/cap",
"Beclovent Rotacaps 100mcg",
"Beclovent Rotacaps 200mcg",
"Beconase AQ",
"Beconase AQ",
"Beconase AQ",
"Beconase AQ",
"Beconase AQ Nasal Aem 50mcg/aem",
"Beconase Nasal Aem 50mcg/aem",
"Mylan-beclo AQ",
"Propaderm",
"Propaderm Cream 0.025%",
"Propaderm Lot 0.025%",
"Propaderm Lotion 0.025%",
"Qnasl",
"Qnasl",
"Qnasl",
"Qnasl",
"Qnasl",
"Qnasl",
"Qvar",
"Qvar",
"Qvar",
"Qvar",
"Qvar",
"Qvar",
"Qvar",
"Qvar",
"Qvar",
"Qvar",
"Qvar",
"Qvar",
"Qvar",
"Qvar",
"Qvar",
"Qvar Redihaler",
"Qvar Redihaler",
"Qvar Redihaler",
"Qvar Redihaler",
"Qvar Redihaler",
"Qvar Redihaler",
"Qvar Redihaler",
"Qvar Redihaler",
"Ratio-beclomethasone AQ",
"Riarify",
"Riarify",
"Riarify",
"Riarify",
"Riarify",
"Rivanase AQ.nasal Spray 50mcg/metered Dose",
"Trimbow",
"Trimbow",
"Trimbow",
"Trimbow",
"Trimbow",
"Trimbow",
"Trimbow",
"Trimbow",
"Trimbow",
"Trimbow",
"Trimbow",
"Trimbow",
"Trydonis",
"Trydonis",
"Trydonis",
"Trydonis",
"Trydonis",
"Trydonis",
"Trydonis",
"Trydonis",
"Vancenase Aer 50mcg",
"Vanceril Aem 50mcg"
] |
[
"Aerobec",
"Aldecin",
"Anceron",
"Andion",
"Beclacin",
"Becloforte",
"Beclomet",
"Beclorhinol",
"Becloval",
"Beclovent",
"Becodisks",
"Beconase",
"Beconasol",
"Becotide",
"Clenil-A",
"Entyderma",
"Inalone",
"Korbutone",
"orBec",
"Rino-Clenil",
"Rivanase",
"Sanasthmax",
"Sanasthmyl",
"Vancenase",
"Vanceril"
] |
[
"Trydonis",
"Trydonis",
"Trydonis",
"Trydonis",
"Trydonis",
"Trydonis",
"Trydonis",
"Trydonis",
"Trimbow",
"Trimbow",
"Trimbow",
"Trimbow",
"Trimbow",
"Trimbow",
"Trimbow",
"Trimbow",
"Trimbow",
"Trimbow",
"Trimbow",
"Trimbow",
"Riarify",
"Riarify",
"Riarify",
"Riarify",
"Riarify"
] |
[
"P04150"
] |
[
"P20815",
"P08684"
] |
[
"P08185"
] |
[
"P08183",
"Q9UNQ0",
"Q9Y6L6",
"Q9NPD5"
] |
DB00395
|
Carisoprodol
|
Originally approved by the FDA in 1959 [FDA label], carisoprodol is a centrally acting muscle relaxant used in painful musculoskeletal conditions in conjunction with physical therapy and other medications [A176047]. This drug is available by itself in an oral tablet or combined with aspirin, or in a fixed-dose combination with both aspirin and codeine [FDA label, F4060, F4069].
In January 2012, this drug was classified as a Schedule IV substance under the controlled substances act in several US states due to alarming rates of abuse [A176062, A176077] despite having a low potential for abuse in addition to a low risk of dependence [L5074].
|
solid
|
Carisoprodol is indicated for the relief of discomfort related to acute, painful musculoskeletal conditions [FDA label].
**Important limitations of use** [FDA label]:
• Should only be used for acute treatment periods up to two or three weeks
• Adequate evidence of effectiveness for more prolonged use has not been established
• Not recommended in pediatric patients less than 16 years of age
|
Carisoprodol is a centrally acting skeletal muscle relaxant that does not act directly on skeletal muscle but acts directly on the central nervous system (CNS). This drug relieves the painful effects of muscle spasm [A176101, F4093]. A metabolite of carisoprodol, _meprobamate_, possesses both anxiolytic and sedative properties [FDA label]. Clinical studies have shown that this drug causes impairment of psychomotor performance in neuropsychological tests.[A176062, A176095]
|
The mechanism of action of carisoprodol in relieving discomfort associated with acute painful musculoskeletal conditions has not been confirmed.
In studies using animal models, the muscle relaxation that is induced by carisoprodol is associated with a change in the interneuronal activity of the spinal cord and of the descending reticular formation, located in the brain.[FDA label]
The abuse potential of this drug is attributed to its ability to alter GABAA function.[A176077] This drug has been shown to modulate a variety of GABAA receptor subunits.[A176062, A176068] GABAA receptor modulation can lead to anxiolysis due to inhibitory effects on neurotransmission.[A173848]
|
The absolute bioavailability of carisoprodol has not yet been established. The mean time to peak plasma concentrations (Tmax) of this drug was about 1.5-2 hours in clinical studies [FDA label]. Co-administration of a fatty meal with carisoprodol (350 mg tablet) had no impact on carisoprodol pharmacokinetics [FDA label].
|
The main pathway of carisoprodol is liver metabolism is by the cytochrome enzyme CYP2C19 to form meprobamate. This enzyme exhibits genetic polymorphism, which may affect the metabolism of this drug [FDA label].
|
**LD50 values**
The LD50 values of carisoprodol for rats are 450 mg/kg for intravenous (IV) and intraperitoneal injection, and 1,320 mg/kg for gavage dosing. In mice, the LD50 values are 165 mg/kg for intravenous injection, 980 mg/kg for intraperitoneal injection, and 2,340 mg/kg for gavage dosing. The LD50 value for rabbits given carisoprodol by intravenous injection is 124 mg/kg [F4078].
**Overdose**
An overdose of carisoprodol leads to CNS depression, and in severe cases, induction of a coma. Shock, depression of respiratory function, seizures and death have also been reported in rare cases. Several symptoms may be associated with carisoprodol overdose, such as horizontal and vertical nystagmus, blurred vision, mydriasis, mild tachycardia and hypotension, respiratory depression, euphoria, CNS stimulation, muscular incoordination, and/or rigidity, confusion, headache, hallucinations, and dystonic reactions. Alcohol or other CNS depressants or psychotropic agents can exert additive effects on carisoprodol even when one of the agents has been ingested at the normal, therapeutic dose. Fatal accidental and non-accidental overdoses have both been reported with carisoprodol ingestion alone or ingestion of carisoprodol in combination with alcohol or psychotropic drugs [F4057].
**A note on dependence and withdrawal**
In the postmarketing reports after carisoprodol use, cases of dependence, withdrawal, and abuse have been reported with long-term use. The majority of dependence and withdrawal cases, as well as abuse, have occurred in patients with a history of addiction or who have used this drug in combination with other drugs having abuse potential. However, multiple post-marketing adverse event reports have been made of carisodopril-associated abuse when used without other drugs possessing abuse potential. Withdrawal symptoms have been observed and reported following sudden abrupt cessation after long-term carisodoprol use. To reduce the chance of carisodopril dependence, withdrawal, or abuse, carisodopril should be used with caution in addiction-prone patients and in patients taking other CNS depressants including alcohol. This drug should not be taken for longer than 2 to 3 weeks for symptomatic relief of acute musculoskeletal discomfort [FDA label].
**Use in pregnancy**
This drug has been classified as Pregnancy Category C. There are no clinical trial data on the use of carisoprodol during human pregnancy. Animal studies show that carisoprodol crosses the placenta and leads to adverse effects on fetal growth and postnatal survival. In postmarketing reports, the main metabolite, _meprobamate_, has not demonstrated a consistent association between maternal use and an increased risk for specific congenital malformations [FDA label].
**Use in nursing**
Limited data in humans demonstrate that this is found excreted in breast milk and may reach concentrations in breast milk of 2-4 times the maternal plasma concentrations [FDA label]. It is therefore advisable to exercise caution when this drug is used during breastfeeding [FDA label].
|
The terminal half-life is approximately 2 hours [FDA label].
|
Approximately 60% [L5719].
|
Carisoprodol is eliminated by the kidneys as well as other routes. The half-life of meprobamate is approximately 10 hours [FDA label].
|
0.93 to 1.3 L/kg, according to 4 different clinical studies [A176068].
|
Following an oral dose of carisoprodol, the oral clearance (Cl/F) was 39.52 ± 16.83 L/hour [F4057].
|
Organic compounds
|
Organic acids and derivatives
|
Carboxylic acids and derivatives
|
Amino acids, peptides, and analogues
|
[
"approved"
] |
[
"M03BA",
"M03B",
"M03",
"M",
"M03BA",
"M03B",
"M03",
"M",
"M03BA",
"M03B",
"M03",
"M"
] |
[
"Humans and other mammals"
] |
[
{
"cost": "1.17",
"description": "Carisoprodol powder",
"unit": "g"
},
{
"cost": "3.24",
"description": "Soma 250 mg tablet",
"unit": "tablet"
},
{
"cost": "4.58",
"description": "Soma Compound 200-325 mg tablet",
"unit": "tablet"
},
{
"cost": "5.75",
"description": "Soma 350 mg tablet",
"unit": "tablet"
},
{
"cost": "0.05",
"description": "Flexall 7% gel",
"unit": "g"
},
{
"cost": "0.06",
"description": "Flexall 16% gel",
"unit": "g"
},
{
"cost": "0.08",
"description": "Flexall plus gel",
"unit": "g"
},
{
"cost": "0.57",
"description": "Carisoprodol 350 mg tablet",
"unit": "tablet"
}
] |
[] |
(±)-2-methyl-2-propyl-1,3-propanediol carbamate isopropylcarbamate | (1-methylethyl)carbamic acid 2-(((aminocarbonyl)oxy)methyl)-2-methylpentyl ester | (RS)-2-{[(aminocarbonyl)oxy]methyl}-2-methylpentyl isopropylcarbamate | 2-methyl-2-propyl-1,3-propanediol carbamate isopropylcarbamate | 2-methyl-2-propyltrimethylene carbamate isopropylcarbamate | carbamic acid 2-isopropylcarbamoyloxymethyl-2-methyl-pentyl ester | Carisoprodol | Carisoprodolo | Carisoprodolum | Isobamate | Isomeprobamate | Isopropyl meprobamate | Isopropylmeprobamate | N-isopropy-2-methyl-2-propyl-1,3-propanediol dicarbamate | GABA(A) receptor subunit alpha-1 | GABAAR subunit alpha-1 | GABA(A) receptor subunit beta-2 | GABAAR subunit beta-2 | GABA(A) receptor subunit gamma-2 | GABAAR subunit gamma-2 | GABA(A) receptor subunit alpha-5 | GABAAR subunit alpha-5 | GABA(A) receptor subunit alpha-3 | GABAAR subunit alpha-3 | (R)-limonene 6-monooxygenase | (S)-limonene 6-monooxygenase | (S)-limonene 7-monooxygenase | 1.14.14.1 | CYPIIC17 | CYPIIC19 | Cytochrome P450-11A | Cytochrome P450-254C | Fenbendazole monooxygenase (4'-hydroxylating) | Mephenytoin 4-hydroxylase
|
[
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol",
"Carisoprodol and Aspirin",
"Carisoprodol and Aspirin",
"Carisoprodol and Aspirin",
"Carisoprodol and Aspirin",
"Carisoprodol and Aspirin",
"Carisoprodol and Aspirin",
"Carisoprodol and Aspirin",
"Carisoprodol and Aspirin",
"Carisoprodol and Aspirin",
"CARISOPRODOL Immediate release",
"Carisoprodol Tablets, USP, 350 mg",
"Carisoprodol, Aspirin and Codeine Phosphate",
"Carisoprodol, Aspirin and Codeine Phosphate",
"Carisoprodol, Aspirin and Codeine Phosphate",
"Carisoprodol, Aspirin and Codeine Phosphate",
"Carisoprodol, Aspirin and Codeine Phosphate",
"Prazolamine",
"Soma",
"Soma",
"Soma",
"Soma",
"Soma",
"Soma",
"Soma",
"Soma",
"Soma",
"Soma Tablets 350mg",
"Vanadom"
] |
[
"Carisoma",
"Gencari",
"Genesafe",
"Hiranin",
"Listaflex",
"Sanoma",
"Tensaprin"
] |
[
"Carisoprodol and Aspirin",
"Carisoprodol and Aspirin",
"Prazolamine",
"Carisoprodol and Aspirin",
"Carisoprodol, Aspirin and Codeine Phosphate",
"Soma",
"Soma",
"Carisoprodol and Aspirin",
"Carisoprodol and Aspirin",
"Carisoprodol, Aspirin and Codeine Phosphate",
"Carisoprodol, Aspirin and Codeine Phosphate",
"Carisoprodol, Aspirin and Codeine Phosphate",
"Carisoprodol and Aspirin",
"Carisoprodol, Aspirin and Codeine Phosphate",
"Carisoprodol and Aspirin",
"Carisoprodol and Aspirin",
"Carisoprodol and Aspirin"
] |
[
"P14867",
"P47870",
"P18507",
"P31644",
"P34903"
] |
[
"P33261"
] |
[] |
[] |
DB00396
|
Progesterone
|
Progesterone is a hormone that occurs naturally in females, and is essential for endometrial receptivity, embryo implantation, and the successful establishment of pregnancy. A low progesterone concentration or an insufficient response to progesterone can cause infertility and pregnancy loss [A175609]. Progesterone is used in various contraceptive preparations to prevent ovulation and fertilization [T481], [A175612] as well as in other formulations to promote and support pregnancy. Please see [Medroxyprogesterone acetate], [Megestrol acetate], [Dydrogesterone] and [Hydroxyprogesterone] entries for information on various other forms of progesterone.
Pharmaceutical progesterone is made from a plant source as a starting material and is chemically identical to progesterone of human ovarian origin [FDA label]. Progesterone is available in gelatinized capsule form, vaginal gel form, tablet form, vaginal insert form, and injection form, all used for various purposes [Label,F3898,F3904,F3901,F3907].
|
solid
|
**Gelatinized capsules**
The gelatinized capsules are indicated for use in the prevention of endometrial hyperplasia in non-hysterectomized postmenopausal women who are receiving conjugated estrogens tablets. They are also indicated for use in secondary amenorrhea [FDA label].
**Vaginal gel**
Progesterone gel (8%) is indicated as progesterone supplementation or replacement as part of an Assisted Reproductive Technology (“ART”) treatment for infertile women with progesterone deficiency. The lower concentration progesterone gel (4%) is used in the treatment of secondary amenorrhea, with the use of the 8% concentration if there is no therapeutic response to the 4% gel [F3898].
**Vaginal insert**
This form is indicated to support embryo implantation and early pregnancy by supplementation of corpus luteal function as part of an Assisted Reproductive Technology (ART) treatment program for infertile women [F3901].
**Injection (intramuscular)**
This drug is indicated in amenorrhea and abnormal uterine bleeding due to hormonal imbalance in the absence of organic pathology, such as submucous fibroids or uterine cancer [F3907].
**Tablets, contraceptive**
The tablet form of progesterone in contraceptive formulations is indicated for the prevention of pregnancy [F3904].
|
Progesterone, depending on concentration and dosage form, and timing of exposure may have several pharmacodynamic effects. These actions, according, to various preparations, are listed below:
General effects
Progesterone is the main hormone of the corpus luteum and the placenta. It acts on the uterus by changing the proliferative phase to the secretory phase of the endometrium (inner mucous lining of the uterus). This hormone, stimulated by a hormone called _luteinizing hormone_ (LH) is the main hormone during the secretory phase to prepare the corpus luteum and the endometrium for implantation of a fertilized ovum. As the luteal phase concludes, the progesterone hormone sends negative feedback to the anterior pituitary gland in the brain to decrease FSH (follicle stimulating hormone) and LH (luteinizing hormone) levels. This prevents ovulation and maturation of oocytes (immature egg cells). The endometrium then prepares for pregnancy by increasing its vascularity (blood vessels) and stimulating mucous secretion. This process occurs by progesterone stimulating the endometrium to decrease endometrial proliferation, leading to a decreased uterine lining thickness, developing more complex uterine glands, collecting energy in the form of glycogen, and providing more uterine blood vessel surface area suitable for supporting a growing embryo. As opposed to cervical mucous changes observed during the proliferative phase and ovulation, progesterone decreases and thickens the cervical mucus, rendering it less elastic. This change occurs because the fertilization time period has passed, and a specific consistency of mucous amenable to sperm entry is no longer required [T490].
**Gelatinized capsules**
Progesterone capsules are an oral dosage form of micronized progesterone which, chemically identical to progesterone of ovarian origin. Progesterone capsules have all the properties of endogenous progesterone with induction of a secretory phase endometrium with gestagenic, antiestrogenic, slightly antiandrogenic and anti-aldosterone effects [F3913]. Progesterone opposes the effects of estrogen on the uterus, and is beneficial in women with unopposed estrogen exposure, which carries an increased risk of malignancy [F3913].
**Vaginal gel and vaginal insert**
The gel preparation mimics the effects of naturally occurring progesterone. In the presence of adequate levels of estrogen, progesterone converts a proliferative endometrium into secretory endometrium. This means that the endometrium changes from a growing and thickening stage into a subsequent preparation stage for pregnancy, which involves further preparatory changes. Progesterone is necessary for the development of decidual tissue (specialized tissue amenable to supporting a possible pregnancy). Progesterone is required to increase endometrial receptivity for the implantation of a fertilized embryo. Once an embryo is implanted, progesterone helps to maintain the pregnancy [F3898].
**Injection (intramuscular)**
Intramuscularly injected progesterone increases serum progesterone and aids in the prevention of endometrial tissue overgrowth due to unopposed estrogen (which leads to abnormal uterine bleeding and sometimes uterine cancer) [L5638], [F3916]. In the absence or deficiency of progesterone, the endometrium continually proliferates, eventually outgrowing its limited blood supply, shedding incompletely, and leading to abnormal and/or profuse bleeding as well as malignancy [L5638].
**Tablets, contraceptive**
Progesterone-only contraceptive tablets prevent conception by suppressing ovulation in about half of users, causing a thickening of cervical mucus to inhibit sperm movement, lowering the midcycle LH and FSH hormone peaks, slowing the movement of the ovum through the fallopian tubes, and causing secretory changes in the endometrium as described above [F3904].
|
Progesterone binds and activates its nuclear receptor, _PR_, which plays an important part in the signaling of stimuli that maintain the endometrium during its preparation for pregnancy.
Progesterone receptor (PR) is a member of the nuclear/steroid hormone receptor (SHR) family of ligand-dependent transcription factors that is expressed primarily in female reproductive tissue as well as the central nervous system. As a result of its binding its associated steroid hormone, progesterone, the progesterone receptor (PR) modulates the expression of genes that regulate the development, differentiation, and proliferation of target tissues [A175666]. In humans, PR is found to be highly expressed in the stromal (connective tissue) cells during the secretory phase and during pregnancy [A175651].
Progesterone may prevent pregnancy by changing the consistency of cervical mucus to be unfavorable for sperm penetration, and by inhibiting follicle-stimulating hormone (FSH), which normally causes ovulation. With perfect use, the first-year failure rate for progestin-only oral contraceptives is approximately 0.5%. The typical failure rate, however, is estimated to be approximately 5%, due to late or missed pills [F3904].
|
**Oral micronized capsules**
Following oral administration of progesterone in the micronized soft-gelatin capsule formulation, peak serum concentration was achieved in the first 3 hours. The absolute bioavailability of micronized progesterone is unknown at this time. In postmenopausal women, serum progesterone concentration increased in a dose-proportional and linear fashion after multiple doses of progesterone capsules, ranging from 100 mg/day to 300 mg/day [FDA label].
**IM administration**
After intramuscular (IM) administration of 10 mg of progesterone in oil, the maximum plasma concentrations were achieved in about 8 hours post-injection and plasma concentrations stayed above baseline for approximately 24 hours post-injection. Injections of 10, 25, and 50 mg lead to geometric mean values for maximum plasma concentration (CMAX) of 7, 28, and 50 ng/mL, respectively [F3916]. Progesterone administered by the intramuscular (IM) route avoids significant first-pass hepatic metabolism. As a result, endometrial tissue concentrations of progesterone achieved with IM administration are higher when compared with oral administration. Despite this, the highest concentrations of progesterone in endometrial tissue are reached with vaginal administration [A175657].
**Note on oral contraceptive tablet absorption**
Serum progestin levels peak about 2 hours after oral administration of progesterone-only contraceptive tablets, followed by rapid distribution and elimination. By 24 hours after drug administration, serum levels remain near the baseline, making efficacy dependent upon strict adherence to the dosing schedule. Large variations in serum progesterone levels occur among individuals. Progestin-only administration leads to lower steady-state serum progestin levels and a shorter elimination half-life than concurrent administration with estrogens [F3904].
|
Progesterone is mainly metabolized by the liver. After oral administration, the major plasma metabolites found are 20 a hydroxy-Δ4 a-prenolone and 5 a-dihydroprogesterone. Some progesterone metabolites are found excreted in the bile and these metabolites may be deconjugated and subsequently metabolized in the gut by reduction, dehydroxylation, and epimerization [FDA label]. The major plasma and urinary metabolites are comparable to those found during the physiological progesterone secretion of the corpus luteum [F3913].
|
Intraperitoneal LD50 (rat): 327 mg/kg [MSDS].
**Use in pregnancy**
Only forms of progesterone that are indicated on product labeling for pregnancy should be used. Some forms of progesterone should not be used in pregnancy [FDA label], [F3904]. Refer to individual product monographs for information regarding use in pregnancy. Many studies have found no effects on fetal development associated with long-term use of contraceptive doses of oral progestins. Studies of infant growth and development that have been conducted have not demonstrated significant adverse effects, however, these studies are few in number. It is therefore advisable to rule out suspected pregnancy before starting any hormonal contraceptive [F3904].
**Effects on fertility**
Progesterone at high doses is an antifertility drug and high doses would be expected to impair fertility until cessation [F3916]. The progesterone contraceptive should not be used during pregnancy.
**Carcinogenicity**
Progesterone has been shown to induce or promote the formation of ovarian, uterine, mammary, and genital tract tumors in animals. The clinical relevance of these findings is unknown [F3913]. Certain epidemiological studies of patients using oral contraceptives have reported an increased relative risk of developing breast cancer, especially at a younger age and associated with a longer duration of use. These studies have mainly involved combined oral contraceptives, and therefore, it is unknown whether this risk is attributable to progestins, estrogens, or a combination of both. At this time, there is insufficient data to determine whether the use of progestin-only contraceptives increases the risk in a similar way to combined contraceptives. A meta-analysis of 54 studies showed a small increase in the frequency of breast cancer diagnosis for women who were currently using combined oral contraceptives, or had used them within the past 10 years. There was no increase in the frequency of having breast cancer diagnosed ten or more years after cessation of hormone use. Women with breast cancer should not use oral contraceptives, as there is no sufficient data to fully establish or negate the risk of cancer with hormonal contraceptive use [F3904].
**Use in breastfeeding**
Progesterone has been detected in the milk of nursing mothers [F3901], [F3904]. No adverse effects, in general, have been found on breastfeeding ability or on the health, growth, or development of the growing infant. Despite this, isolated post-marketing cases of decreased milk production have been reported [F3904].
|
Absorption half-life is approximately 25-50 hours and an elimination half-life of 5-20 minutes (progesterone gel) [F3898].
Progesterone, administered orally, has a short serum half-life (approximately 5 minutes). It is rapidly metabolized to _17-hydroxyprogesterone_ during its first pass through the liver [A175657].
|
96%-99% bound to serum proteins, primarily to serum albumin (50%-54%) and transcortin (43%-48%) [FDA label].
|
Progesterone metabolites are excreted mainly by the kidneys. Urinary elimination is observed for 95% of patients in the form of glycuroconjugated metabolites, primarily 3 a, 5 ß–pregnanediol (_pregnandiol_) [F3913]. The glucuronide and sulfate conjugates of pregnanediol and pregnanolone are excreted in the urine and bile. Progesterone metabolites, excreted in the bile, may undergo enterohepatic recycling or may be found excreted in the feces.
|
When administered vaginally, progesterone is well absorbed by uterine endometrial tissue, and a small percentage is distributed into the systemic circulation.
The amount of progesterone in the systemic circulation appears to be of minimal importance, especially when implantation, pregnancy, and live birth outcomes appear similar for intramuscular and vaginal administration of progesterone [A175657].
|
**Apparent clearance**
1367 ± 348 (50mg of progesterone administered by vaginal insert once daily) [A175657].
106 ± 15 L/h (50mg/mL IM injection once daily) [A175657].
|
Organic compounds
|
Lipids and lipid-like molecules
|
Steroids and steroid derivatives
|
Pregnane steroids
|
[
"approved",
"vet_approved"
] |
[
"G03FA",
"G03F",
"G03",
"G",
"G03DA",
"G03D",
"G03",
"G"
] |
[
"Humans and other mammals"
] |
[
{
"cost": "1.69",
"description": "Prometrium 100 mg capsule",
"unit": "capsule"
},
{
"cost": "2.88",
"description": "First-progesterone vgs 25 suppository",
"unit": "each"
},
{
"cost": "2.93",
"description": "First-progesterone vgs 50 suppository",
"unit": "each"
},
{
"cost": "3.0",
"description": "First-progesterone vgs 100 suppository",
"unit": "each"
},
{
"cost": "3.15",
"description": "First-progesterone vgs 200 suppository",
"unit": "each"
},
{
"cost": "3.33",
"description": "First-progesterone vgs 400 susuppositoryp",
"unit": "each"
},
{
"cost": "3.84",
"description": "Prometrium 200 mg capsule",
"unit": "capsule"
},
{
"cost": "3.88",
"description": "Progesterone oil 50 mg/ml vial",
"unit": "ml"
},
{
"cost": "6.6",
"description": "Progesterone 50 mg/ml",
"unit": "ml"
},
{
"cost": "8.56",
"description": "Prochieve 4% gel",
"unit": "g"
},
{
"cost": "12.0",
"description": "Prochieve 8% gel",
"unit": "g"
},
{
"cost": "13.61",
"description": "Crinone 8% gel",
"unit": "g"
},
{
"cost": "14.83",
"description": "Prochieve 8% Gel 1.45 gm Tube",
"unit": "tube"
},
{
"cost": "84.26",
"description": "Crinone 8% Gel (1 Box = 6 Applications)",
"unit": "box"
},
{
"cost": "160.18",
"description": "Prochieve 4% Gel (18 Applicators Per Box)",
"unit": "tube"
},
{
"cost": "0.73",
"description": "Progesterone powder milled",
"unit": "g"
},
{
"cost": "0.74",
"description": "Progesterone powder micronized",
"unit": "g"
}
] |
[
{
"approved": "1996-08-06",
"country": "United States",
"expires": "2013-09-15",
"number": "5543150"
},
{
"approved": "2007-11-27",
"country": "United States",
"expires": "2019-11-17",
"number": "7300664"
},
{
"approved": "2008-01-22",
"country": "United States",
"expires": "2019-11-17",
"number": "7320800"
},
{
"approved": "2008-07-01",
"country": "United States",
"expires": "2019-11-17",
"number": "7393543"
},
{
"approved": "2015-04-14",
"country": "United States",
"expires": "2032-11-21",
"number": "9006222"
},
{
"approved": "2015-08-25",
"country": "United States",
"expires": "2032-11-21",
"number": "9114145"
},
{
"approved": "2014-09-30",
"country": "United States",
"expires": "2032-11-21",
"number": "8846649"
},
{
"approved": "2016-04-05",
"country": "United States",
"expires": "2032-11-21",
"number": "9301920"
},
{
"approved": "2014-09-30",
"country": "United States",
"expires": "2032-11-21",
"number": "8846648"
},
{
"approved": "2015-08-25",
"country": "United States",
"expires": "2032-11-21",
"number": "9114146"
},
{
"approved": "2014-01-21",
"country": "United States",
"expires": "2032-11-21",
"number": "8633178"
},
{
"approved": "2018-08-21",
"country": "United States",
"expires": "2032-11-21",
"number": "10052386"
},
{
"approved": "2015-03-31",
"country": "United States",
"expires": "2032-11-21",
"number": "8993548"
},
{
"approved": "2015-03-24",
"country": "United States",
"expires": "2032-11-21",
"number": "8987237"
},
{
"approved": "2015-03-31",
"country": "United States",
"expires": "2032-11-21",
"number": "8993549"
},
{
"approved": "2019-02-19",
"country": "United States",
"expires": "2032-11-21",
"number": "10206932"
},
{
"approved": "2020-05-05",
"country": "United States",
"expires": "2032-11-21",
"number": "10639375"
},
{
"approved": "2020-02-04",
"country": "United States",
"expires": "2029-02-03",
"number": "10548904"
},
{
"approved": "2013-11-12",
"country": "United States",
"expires": "2030-01-21",
"number": "8580293"
},
{
"approved": "2020-01-21",
"country": "United States",
"expires": "2029-02-03",
"number": "10537584"
},
{
"approved": "2020-06-09",
"country": "United States",
"expires": "2032-11-21",
"number": "10675288"
},
{
"approved": "2020-10-20",
"country": "United States",
"expires": "2032-11-21",
"number": "10806740"
},
{
"approved": "2021-06-15",
"country": "United States",
"expires": "2032-11-21",
"number": "11033626"
},
{
"approved": "2021-08-31",
"country": "United States",
"expires": "2032-11-21",
"number": "11103513"
},
{
"approved": "2021-09-07",
"country": "United States",
"expires": "2032-11-21",
"number": "11110099"
},
{
"approved": "2021-08-31",
"country": "United States",
"expires": "2032-11-21",
"number": "11103516"
},
{
"approved": "2015-01-13",
"country": "United States",
"expires": "2032-11-21",
"number": "8933059"
},
{
"approved": "2021-11-09",
"country": "United States",
"expires": "2032-11-21",
"number": "11166963"
},
{
"approved": "2012-11-21",
"country": "United States",
"expires": "2032-11-21",
"number": "11529360"
},
{
"approved": "2012-11-21",
"country": "United States",
"expires": "2032-11-21",
"number": "11793819"
},
{
"approved": "2012-11-21",
"country": "United States",
"expires": "2032-11-21",
"number": "11865179"
}
] |
(S)-4-Pregnene-3,20-dione | (S)-Pregn-4-en-3,20-dione | (S)-Progesterone | 17alpha-Progesterone | 17α-progesterone | 4-Pregnene-3,20-dione | Agolutin | Akrolutin | Corpus Luteum Hormone | delta(4)-Pregnene-3,20-dione | Gelbkörperhormon | Luteohormone | Lutogynon | Pregn-4-ene-3,20-dione | Progesteron | Progesterona | Progestérone | Progesterone | Progesteronum | NR3C3 | Nuclear receptor subfamily 3 group C member 3 | PR | MCR | MLR | MR | Nuclear receptor subfamily 3 group C member 2 | ER | ER-alpha | ESR | Estradiol receptor | NR3A1 | Nuclear receptor subfamily 3 group A member 1 | 1.14.14.19 | 17-alpha-hydroxyprogesterone aldolase | CYP17 | CYPXVII | Cytochrome P450 17A1 | Cytochrome P450-C17 | Cytochrome P450c17 | S17AH | Steroid 17-alpha-monooxygenase | K-OR-1 | KOR-1 | OPRK | AGP 1 | AGP1 | OMD 1 | Orosomucoid-1 | GR | GRL | Nuclear receptor subfamily 3 group C member 1 | DHTR | Dihydrotestosterone receptor | NR3C4 | Nuclear receptor subfamily 3 group C member 4 | ABP | SBP | Sex steroid-binding protein | SHBG | TeBG | Testis-specific androgen-binding protein | Testosterone-estradiol-binding globulin | Testosterone-estrogen-binding globulin | ER-beta | ESTRB | NR3A2 | Nuclear receptor subfamily 3 group A member 2 | 1.14.14.19 | 17-alpha-hydroxyprogesterone aldolase | CYP17 | CYPXVII | Cytochrome P450 17A1 | Cytochrome P450-C17 | Cytochrome P450c17 | S17AH | Steroid 17-alpha-monooxygenase | 1.14.14.1 | CYPIA1 | Cytochrome P450 form 6 | Cytochrome P450-C | Cytochrome P450-P1 | Hydroperoxy icosatetraenoate dehydratase | 1.14.14.1 | CYPIB1 | Hydroperoxy icosatetraenoate dehydratase | 1,4-cineole 2-exo-monooxygenase | 1.14.14.- | Coumarin 7-hydroxylase | CYP2A3 | CYPIIA6 | Cytochrome P450 IIA3 | Cytochrome P450(I) | 1.14.14.- | Cholesterol 25-hydroxylase | CYP2DL1 | CYPIID6 | Cytochrome P450-DB1 | Debrisoquine 4-hydroxylase | (R)-limonene 6-monooxygenase | (S)-limonene 6-monooxygenase | (S)-limonene 7-monooxygenase | 1.14.14.1 | CYPIIC17 | CYPIIC19 | Cytochrome P450-11A | Cytochrome P450-254C | Fenbendazole monooxygenase (4'-hydroxylating) | Mephenytoin 4-hydroxylase | (R)-limonene 6-monooxygenase | (S)-limonene 6-monooxygenase | (S)-limonene 7-monooxygenase | 1.14.14.1 | Cholesterol 25-hydroxylase | CYP2C10 | CYPIIC9 | Cytochrome P-450MP | Cytochrome P450 MP-4 | Cytochrome P450 MP-8 | Cytochrome P450 PB-1 | S-mephenytoin 4-hydroxylase | 1.14.14.1 | CYPIIIA5 | Cytochrome P450-PCN3 | 1,4-cineole 2-exo-monooxygenase | 1,8-cineole 2-exo-monooxygenase | 1.14.14.1 | Albendazole monooxygenase (sulfoxide-forming) | Albendazole sulfoxidase | Cholesterol 25-hydroxylase | CYP3A3 | CYPIIIA3 | CYPIIIA4 | Cytochrome P450 3A3 | Cytochrome P450 HLp | Cytochrome P450 NF-25 | Cytochrome P450-PCN1 | Nifedipine oxidase | Quinine 3-monooxygenase | 1.14.14.1 | CYPIIIA7 | Cytochrome P450-HFLA | P450HLp2 | ATP-binding cassette sub-family B member 1 | MDR1 | Multidrug resistance protein 1 | P-glycoprotein 1 | PGY1 | Phospholipid transporter ABCB1 | hOCT2 | OCT2 | Organic cation transporter 2 | hOCT1 | OCT1 | Organic cation transporter 1 | EMT | EMTH | Extraneuronal monoamine transporter | OCT3 | Organic cation transporter 3 | 7.6.2.- | ATP-binding cassette sub-family B member 11 | BSEP | 7.6.2.2 | ATP-binding cassette sub-family C member 1 | Glutathione-S-conjugate-translocating ATPase ABCC1 | Leukotriene C(4) transporter | LTC4 transporter | MRP | MRP1 | Cell growth-inhibiting gene 29 protein | Na(+)/bile acid cotransporter | Na(+)/taurocholate transport protein | NTCP | SLC10A1 | Sodium/taurocholate cotransporting polypeptide | Solute carrier family 10 member 1 | Liver-specific organic anion transporter 1 | LST-1 | LST1 | OATP-2 | OATP-C | OATP1B1 | OATP2 | OATPC | Organic anion transporter SLC21A6 | SLC21A6 | SLCO1B1 | Sodium-independent organic anion-transporting polypeptide 2 | Solute carrier family 21 member 6 | 7.6.2.2 | ABCP | ATP-binding cassette sub-family G member 2 | BCRP | BCRP1 | Breast cancer resistance protein | CDw338 | Mitoxantrone resistance-associated protein | MXR | Placenta-specific ATP-binding cassette transporter | Urate exporter | Liver-specific organic anion transporter 2 | LST-2 | LST2 | OATP-8 | OATP1B3 | OATP8 | Organic anion transporter 8 | Organic anion-transporting polypeptide 8 | SLC21A8 | Solute carrier family 21 member 8
|
[
"Ach-progesterone",
"Act Progesterone Injection",
"Advanced Formula Progesto-Life",
"Auro-progesterone",
"Bijuva",
"Bijuva",
"Bijuva",
"Bijuva",
"Bijuva",
"Bijuva",
"Crinone",
"Crinone",
"Crinone",
"Crinone",
"Crinone",
"Crinone",
"Crinone",
"Crinone",
"Crinone",
"Crinone",
"Endometrin",
"Endometrin",
"Estradiol and Progesterone",
"Estrogel Propak",
"Eugia-progesterone",
"Ferring Pharmaceuticals Inc.",
"Fluocinolone Acetonide 0.01% / Minoxidil 7% / Progesterone 0.1%",
"Gesterol In Oil-liq Im 50mg/ml",
"Inprosub",
"M-progesterone",
"Minoxidil 5% / Progesterone 0.1% / Tretinoin 0.025%",
"Minoxidil 7% / Progesterone 0.1%",
"Minoxidil 7% / Progesterone 0.1% / Tretinoin 0.025%",
"P25 Progesterone Cream",
"P50 Progesterone Cream",
"P75 Lav Progesterone Cream",
"P75 Maxx with Retinol All Natural Progesterone 75 Cream",
"PMS-progesterone",
"PMS-progesterone",
"PMS-progesterone Inj 50mg/ml USP",
"Prochieve",
"Prochieve",
"Progesterona",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone",
"Progesterone Inj 50mg/ml USP",
"Progesterone Injection, USP",
"Progesto-Life",
"Progestrona",
"Prometrium",
"Prometrium",
"Prometrium",
"Prometrium",
"Prometrium",
"Prometrium",
"Prometrium",
"Prometrium",
"Prometrium",
"Prometrium",
"Prometrium",
"Prometrium",
"Reddy-progesterone",
"Teva-progesterone",
"Utrogestan"
] |
[
"Agolutin",
"Cyclogest",
"Gesterol",
"Gestone",
"Progestasert",
"Progestogel",
"Qi Ning",
"Relantan",
"Susten",
"Utrogestran",
"Utrovin",
"Vasclor"
] |
[
"Minoxidil 7% / Progesterone 0.1%",
"Minoxidil 7% / Progesterone 0.1% / Tretinoin 0.025%",
"Minoxidil 5% / Progesterone 0.1% / Tretinoin 0.025%",
"Fluocinolone Acetonide 0.01% / Minoxidil 7% / Progesterone 0.1%",
"Bijuva",
"Estrogel Propak",
"Bijuva",
"Bijuva",
"Estradiol and Progesterone",
"Bijuva",
"Bijuva",
"Bijuva"
] |
[
"P06401",
"P08235",
"P03372",
"P05093",
"P41145",
"P02763",
"P04150",
"P10275",
"P04278",
"Q92731"
] |
[
"P05093",
"P04798",
"Q16678",
"P11509",
"P10635",
"P33261",
"P11712",
"P20815",
"P08684",
"P24462"
] |
[] |
[
"P08183",
"O15244",
"O15245",
"O75751",
"O95342",
"P33527",
"Q14973",
"Q9Y6L6",
"Q9UNQ0",
"Q9NPD5"
] |
DB00741
|
Hydrocortisone
|
Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex.[A188387] Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone.[A188420]
Hydrocortisone was granted FDA approval on 5 August 1952.[L10574]
|
solid
|
Otic solutions are indicated for infections of the external auditory canal caused by susceptible organisms and with inflammation.[L10529,L10532] Hydrocortisone tablets are indicated for certain endocrine, rheumatic, collagen, allergic, ophthalmic, respiratory, hematologic, neoplastic, edematous, gastrointestinal, and other conditions.[L10535] A hydrocortisone enema is indicated for ulcerative colitis,[L10538] a topical ointment with antibiotics is indicated for corticosteroid responsive dermatoses with infections,[L7772] and a topical cream with [acyclovir] is indicated to treat cold sores.[L7321] Oral granules of hydrocortisone are used as a replacement therapy for Adrenocortical Insufficiency (AI) in children under 17 years of age.[L16533]
|
Hydrocortisone binds to the glucocorticoid receptor leading to downstream effects such as inhibition of phospholipase A2, NF-kappa B, other inflammatory transcription factors, and the promotion of anti-inflammatory genes.[A187463] Hydrocortisone has a wide therapeutic index[A188405] and a moderate duration of action.[A188354,A188381] Patients should stop taking the medication if irritation or sensitization occurs.[L10529,L10532,L10535,L10538,L7772,L7321]
|
The short-term effects of corticosteroids are decreased vasodilation and permeability of capillaries, as well as decreased leukocyte migration to sites of inflammation.[A187463] Corticosteroids binding to the glucocorticoid receptor mediates changes in gene expression that lead to multiple downstream effects over hours to days.[A187463]
Glucocorticoids inhibit neutrophil apoptosis and demargination; they inhibit phospholipase A2, which decreases the formation of arachidonic acid derivatives; they inhibit NF-Kappa B and other inflammatory transcription factors; they promote anti-inflammatory genes like interleukin-10.[A187463]
Lower doses of corticosteroids provide an anti-inflammatory effect, while higher doses are immunosuppressive.[A187463] High doses of glucocorticoids for an extended period bind to the mineralocorticoid receptor, raising sodium levels and decreasing potassium levels.[A187463]
|
The pharmacokinetics of hydrocortisone can vary by 10 times from patient to patient.[A188354] Following the oral administration of hydrocortisone at a dose of 0.2-0.3 mg/kg/day, the mean C<sub>max</sub> and AUC of plasma free cortisol were 32.69 nmol/L and 90.63 h x nmol/L, respectively.[A188354] The mean C<sub>max</sub> and AUC of plasma total cortisol were 514.47 nmol/L and 1743.93 h x nmol/L, respectively.[A188354] Following the dose of 0.4-0.6 mg/kg/day, the mean C<sub>max</sub> and AUC of plasma free cortisol were 70.81 nmol/L and 199.11 h x nmol/L.[A188354] The mean C<sub>max</sub> and AUC of plasma total cortisol were 754.94 nmol/L and 2533.02 h x nmol/L, respectively.[A188354]
Topical hydrocortisone cream is 4-19% bioavailable [A188375] with a T<sub>max</sub> of 24h.[A188372]
Hydrocortisone retention enemas have a bioavailability of 0.810 for slow absorbers and 0.502 for rapid absorbers.[A188378] Slow absorbers take up hydrocortisone at a rate of 0.361±0.255/h while fast absorbers take up hydrocortisone at a rate of 1.05±0.255/h.[A188378]
A 20mg IV dose of hydrocortisone has an AUC of 1163±277ng\*h/mL.[A188381]
|
Hydrocortisone is metabolised to 6-beta hydrocortisol via CYP3A, 5-beta tetrahydrocortisol via 3-oxo-5-beta-steroid 4-dehydrogenase, 5-alpha tetrahydrocortisol via 3-oxo-5-alpha-steroid 4-dehydrogenase 2, cortisone via Corticosteroid 11-beta-dehydrogenase isozyme 1 and Corticosteroid 11-beta-dehydrogenase isozyme 2, and glucuronide products.[A188321,A188318] Cortisone is further metabolized to tetrahydrocortisone and dihydrocortisol.[A188321,A188318]
|
Data regarding acute overdoses of glucocorticoids are rare.[L10529,L10532,L10535,L10538,L7772,L7321] Chronic high doses of glucocorticoids can lead to the development of cataract, glaucoma, hypertension, water retention, hyperlipidemia, peptic ulcer, pancreatitis, myopathy, osteoporosis, mood changes, psychosis, dermal atrophy, allergy, acne, hypertrichosis, immune suppression, decreased resistance to infection, moon face, hyperglycemia, hypocalcemia, hypophosphatemia, metabolic acidosis, growth suppression, and secondary adrenal insufficiency.[A188405] Overdose may be treated by adjusting the dose or stopping the corticosteroid as well as initiating symptomatic and supportive treatment.[A188405]
|
Total hydrocortisone via the oral route has a half life of 2.15h while the free fraction has a half life of 1.39h.[A188354] A 20mg IV dose of hydrocortisone has a terminal half life of 1.9±0.4h.[A188381]
|
Corticosteroids are generally bound to corticosteroid binding globulin[A187439] and serum albumin[A187436] in plasma. Hydrocortisone is 90.1% bound to proteins in plasma, with 56.2% bound to albumin.[A184223]
|
Corticosteroids are eliminated predominantly in the urine.[A187436] However, data regarding the exact proportion is not readily available.[A188387]
|
Total hydrocortisone has a volume of distribution of 39.82L, while the free fraction has a volume of distribution of 474.38L.[A188354]
|
Total hydrocortisone by the oral route has a mean clearance of 12.85L/h, while the free fraction has a mean clearance of 235.78L/h.[A188354] A 20mg IV dose of hydrocortisone has a clearance of 18.2±4.2L/h.[A188381]
|
Organic compounds
|
Lipids and lipid-like molecules
|
Steroids and steroid derivatives
|
Hydroxysteroids
|
[
"approved",
"vet_approved"
] |
[
"S01CB",
"S01C",
"S01",
"S",
"A01AC",
"A01A",
"A01",
"A",
"S01BA",
"S01B",
"S01",
"S",
"S01CA",
"S01C",
"S01",
"S",
"D07AA",
"D07A",
"D07",
"D",
"S01BB",
"S01B",
"S01",
"S",
"D07XA",
"D07X",
"D07",
"D",
"D07BA",
"D07B",
"D07",
"D",
"S02CA",
"S02C",
"S02",
"S",
"A07EA",
"A07E",
"A07",
"A",
"S02BA",
"S02B",
"S02",
"S",
"R01AD",
"R01A",
"R01",
"R",
"H02AB",
"H02A",
"H02",
"H",
"D07CA",
"D07C",
"D07",
"D",
"S03CA",
"S03C",
"S03",
"S",
"C05AA",
"C05A",
"C05",
"C"
] |
[
"Humans and other mammals"
] |
[
{
"cost": "1.03",
"description": "Ala-scalp hp 2% lotion",
"unit": "ml"
},
{
"cost": "1.08",
"description": "Procto-kit 1% cream",
"unit": "g"
},
{
"cost": "1.17",
"description": "Westcort 0.2% cream",
"unit": "g"
},
{
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] |
[
{
"approved": "1997-06-03",
"country": "United States",
"expires": "2014-06-03",
"number": "5635497"
},
{
"approved": "2008-05-27",
"country": "United States",
"expires": "2026-12-19",
"number": "7378405"
},
{
"approved": "2011-07-19",
"country": "United States",
"expires": "2025-01-23",
"number": "7981877"
},
{
"approved": "2006-09-05",
"country": "United States",
"expires": "2016-08-02",
"number": "RE39264"
},
{
"approved": "2003-02-04",
"country": "United States",
"expires": "2019-01-24",
"number": "6514980"
},
{
"approved": "2007-05-29",
"country": "United States",
"expires": "2021-07-24",
"number": "7223387"
},
{
"approved": "2017-08-01",
"country": "United States",
"expires": "2032-11-19",
"number": "9717740"
},
{
"approved": "2017-06-13",
"country": "United States",
"expires": "2033-01-10",
"number": "9675559"
},
{
"approved": "2017-05-16",
"country": "United States",
"expires": "2034-05-12",
"number": "9649280"
}
] |
(11β)-11,17,21-trihydroxypregn-4-ene-3,20-dione | 11beta-hydrocortisone | 11beta,17alpha,21-Trihydroxy-4-pregnene-3,20-dione | 11β-hydrocortisone | 17-Hydroxycorticosterone | 4-pregnen-11β,17α,21-triol-3,20-dione | Cortisol | Hidrocortisona | Hydrocortisone | Hydrocortisonum | Kendall's compound F | Reichstein's substance M | GR | GRL | Nuclear receptor subfamily 3 group C member 1 | Annexin I | Annexin-1 | ANX1 | Calpactin II | Calpactin-2 | Chromobindin-9 | Lipocortin I | LPC1 | p35 | Phospholipase A2 inhibitory protein | 1,4-cineole 2-exo-monooxygenase | 1,8-cineole 2-exo-monooxygenase | 1.14.14.1 | Albendazole monooxygenase (sulfoxide-forming) | Albendazole sulfoxidase | Cholesterol 25-hydroxylase | CYP3A3 | CYPIIIA3 | CYPIIIA4 | Cytochrome P450 3A3 | Cytochrome P450 HLp | Cytochrome P450 NF-25 | Cytochrome P450-PCN1 | Nifedipine oxidase | Quinine 3-monooxygenase | 1.14.14.1 | CYPIIIA5 | Cytochrome P450-PCN3 | 1.14.14.1 | CYPIIIA7 | Cytochrome P450-HFLA | P450HLp2 | CYP11B1 | CYPXIB1 | Cytochrome P-450c11 | Cytochrome P450C11 | S11BH | Steroid 11-beta-hydroxylase, CYP11B1 | ALDOS | Aldosterone synthase | Aldosterone-synthesizing enzyme | Corticosterone 18-monooxygenase, CYP11B2 | CYPXIB2 | Cytochrome P-450Aldo | Cytochrome P-450C18 | Steroid 11-beta-hydroxylase, CYP11B2 | Steroid 18-hydroxylase | 1.14.14.1 | CYPIIC8 | Cytochrome P450 form 1 | Cytochrome P450 IIC2 | Cytochrome P450 MP-12 | Cytochrome P450 MP-20 | S-mephenytoin 4-hydroxylase | 1.3.1.3 | 3-oxo-5-beta-steroid 4-dehydrogenase | Delta(4)-3-ketosteroid 5-beta-reductase | Delta(4)-3-oxosteroid 5-beta-reductase | SRD5B1 | 1.3.1.22 | 5 alpha-SR2 | S5AR 2 | SR type 2 | Steroid 5-alpha-reductase 2 | Type II 5-alpha reductase | 1.1.1.- | 11-beta-HSD type II | 11-beta-HSD2 | 11-beta-hydroxysteroid dehydrogenase type II | 11-DH2 | 11-HSD type II | Corticosteroid 11-beta-dehydrogenase isozyme 2 | HSD11K | NAD-dependent 11-beta-hydroxysteroid dehydrogenase | SDR9C3 | Short chain dehydrogenase/reductase family 9C member 3 | 1.1.1.146 | 11-beta-HSD1 | 11-DH | 7-oxosteroid reductase | Corticosteroid 11-beta-dehydrogenase isozyme 1 | HSD11 | HSD11L | SDR26C1 | Short chain dehydrogenase/reductase family 26C member 1 | 1,4-cineole 2-exo-monooxygenase | 1.14.14.- | Coumarin 7-hydroxylase | CYP2A3 | CYPIIA6 | Cytochrome P450 IIA3 | Cytochrome P450(I) | 1.14.14.1 | CYPIB1 | Hydroperoxy icosatetraenoate dehydratase | 1,4-cineole 2-exo-monooxygenase | 1.14.13.- | CYPIIB6 | Cytochrome P450 IIB1 | (R)-limonene 6-monooxygenase | (S)-limonene 6-monooxygenase | (S)-limonene 7-monooxygenase | 1.14.14.1 | Cholesterol 25-hydroxylase | CYP2C10 | CYPIIC9 | Cytochrome P-450MP | Cytochrome P450 MP-4 | Cytochrome P450 MP-8 | Cytochrome P450 PB-1 | S-mephenytoin 4-hydroxylase | (R)-limonene 6-monooxygenase | (S)-limonene 6-monooxygenase | (S)-limonene 7-monooxygenase | 1.14.14.1 | CYPIIC17 | CYPIIC19 | Cytochrome P450-11A | Cytochrome P450-254C | Fenbendazole monooxygenase (4'-hydroxylating) | Mephenytoin 4-hydroxylase | ABP | SBP | Sex steroid-binding protein | SHBG | TeBG | Testis-specific androgen-binding protein | Testosterone-estradiol-binding globulin | Testosterone-estrogen-binding globulin | CBG | Serpin A6 | Transcortin | ATP-binding cassette sub-family B member 1 | MDR1 | Multidrug resistance protein 1 | P-glycoprotein 1 | PGY1 | Phospholipid transporter ABCB1 | OATP | OATP-1 | OATP-A | OATP1 | OATP1A2 | Organic anion-transporting polypeptide 1 | SLC21A3 | Sodium-independent organic anion transporter | Solute carrier family 21 member 3 | hOAT3 | OAT3 | Organic anion/dicarboxylate exchanger | Solute carrier family 22 member 8
|
[
"1% Hydrocortisone",
"141016 Hydrocortisone 0.5% / Hydroquinone 4% / Tretinoin 0.025%",
"141017 Hydrocortisone 0.5% / Hydroquinone 6% / Tretinoin 0.025%",
"141060 Hydrocortisone 0.5% / Hydroquinone 4% / Tretinoin 0.025%",
"141061 Hydrocortisone 0.5% / Hydroquinone 8% / Tretinoin 0.025%",
"999 Itch Relieving",
"999 Itch Relieving",
"Acetasol HC",
"Acetasol HC",
"Advanced Hydrocortisone",
"AFASSCO 1% Hydrocortisone",
"Ala Quin",
"Ala-Scalp",
"Ala-Scalp",
"Alacort",
"Alacort",
"Alcortin",
"Alkindi",
"Alkindi",
"Alkindi",
"Alkindi",
"Alkindi Sprinkle",
"Alkindi Sprinkle",
"Alkindi Sprinkle",
"Alkindi Sprinkle",
"Alkindi Sprinkle",
"Alkindi Sprinkle",
"Aloe Cort",
"Aloe Cort Calming Cream",
"Alumier MD Intensive Recovery",
"Alumier MD Post Procedure Kit with Hydrocortisone",
"Ana Cool Rapid Soothing Cooling Formula",
"Anti Itch",
"Anti itch",
"Anti Itch",
"Anti Itch",
"Anti Itch",
"Anti Itch",
"Anti Itch",
"Anti Itch",
"Anti Itch",
"Anti Itch",
"Anti Itch Maximum Strength",
"Anti Itch Maximum Strength",
"Anti Itch Maximum Strength Plus",
"Anti-Itch",
"Anti-Itch",
"Anti-itch",
"Anti-itch",
"Anti-itch",
"Anti-itch Feminine Care",
"Anti-itch Feminine Care",
"Anti-Itch Regular Strength",
"Anti-Itch Scalp Relief Maximum Strength",
"Anti-Itch Scherer Labs",
"Anti-Itch with Aloe",
"Antibiotic Ear (Neo/Polym/HC)",
"Anusol HC",
"Apres Peel Soothing Balm",
"Aquacort Lotion 2.5%",
"Aquanil HC",
"Aquaphor Itch Relief",
"Assured",
"Atopalm Maximum Strength Anti-Itch",
"ATOPALM Moisturizing Hydrocortisone",
"Audiologist Anti-itch",
"Auro-hydrocortisone",
"Auro-hydrocortisone",
"Avedana Hydrocortisone Cream with Aloe",
"Avedana Hydrocortisone Cream with Aloe",
"Avedana Hydrocortisone Maximum Strength",
"Aveeno Hydrocortisone Anti Itch",
"Aveeno Hydrocortisone ANTI-ITCH",
"Aveeno Hydrocortisone Anti-itch Cream",
"AVON HeXashield Anti Itch Cream with Healing Aloe",
"Barmicil Anti-itch",
"Barmicil Plus",
"Barriere HC 1%",
"Basic Care Hydrocortisone",
"Basic Care Hydrocortisone",
"Basic Care Hydrocortisone",
"Basic Care Hydrocortisone",
"Basic Care Hydrocortisone",
"Basic Case Hydrocortisone Anti-Itch",
"Beard Medicated Cremo",
"Bencort",
"Berkley and Jensen Anti Itch",
"Berkley and Jensen Hydrocortisone",
"Bioelements Immediate Comfort Hydrocortisone",
"Blue-Emu Anti-Itch Cream",
"BudPak Anti-Itch",
"Caldecort",
"Calmurid HC Crm",
"Care One Hydrocortisone Maximum Strength",
"Care One hydrocortisone maximum strength",
"Careone Anti Itch",
"CareOne Anti Itch",
"CareOne Anti Itch",
"Careone Hydrocortisone 1 Maximum Strength",
"Caring Mills Hydrocortisone",
"Casporyn HC",
"CeraVe Anti-Itch",
"CeraVe Developed with Dermatologists Anti Itch",
"Cho-A Care Lot 1%",
"Cicatricure Ultra Moisturizing",
"Cipro",
"Cipro HC",
"Cipro HC",
"Cipro HC",
"Cipro HC",
"Cipro HC",
"Cipro HC",
"Cipro HC",
"Cipro HC",
"Cipro HC Otic Suspension",
"Clindamycin 1% / Hydrocortisone 2.5% / Niacinamide 4%",
"CliniCalm",
"CliniCalm",
"CliniCalm",
"Colocort",
"Cooling Itch Relief",
"Cooling Itch Relief",
"Cooling Itch Relief Rite Aid",
"Cooling Itch Relief Well at Walgreens",
"Cortaid 12-Hour Advanced Anti-Itch",
"Cortaid Intensive Therapy Cooling",
"Cortaid Maximum Strength",
"Cortaid Maximum Strength",
"Cortaid Maximum Strength",
"Cortaine -B Aqueous",
"Cortane-B",
"Cortate Crm 1%",
"Cortate Ont 1%",
"Cortef",
"Cortef",
"Cortef",
"Cortef",
"Cortef",
"Cortef",
"Cortef",
"Cortenema",
"Cortenema",
"Cortenema Sus 100mg/60ml",
"Corti-Sav",
"Corti-Sav",
"Cortibalm",
"Cortibalm",
"Corticol-Aloe",
"Cortisone",
"Cortisone",
"Cortisone 10 Intensive Moisture Creme",
"Cortisone 10 Overnight Creme",
"Cortisone 10 Sensitive Skin Creme",
"Cortisone Cream Intensive Healing",
"Cortisone Maximum Strength",
"Cortisone maximum strength",
"Cortisone Maximum Strength",
"Cortisone Plus Aloe Maximum Strength",
"Cortisporin",
"Cortisporin",
"Cortisporin",
"Cortisporin",
"Cortisporin",
"Cortisporin",
"Cortisporin",
"Cortisporin",
"Cortisporin",
"Cortisporin",
"Cortisporin Ophthalmic",
"Cortizone 10",
"Cortizone 10",
"Cortizone 10 Anti-itch for Diabetics Skin",
"Cortizone 10 Cooling",
"Cortizone 10 Cooling Cream Anti-Itch",
"Cortizone 10 Cooling Relief",
"Cortizone 10 Easy Relief",
"Cortizone 10 Feminine Itch Relief",
"Cortizone 10 for Psoriasis",
"Cortizone 10 Hydratensive Healing Anti Itch",
"Cortizone 10 Hydratensive Soothing Anti Itch",
"Cortizone 10 Intensive Healing",
"Cortizone 10 Intensive Healing Feminine Itch Relief",
"Cortizone 10 Intensive Healing for Eczema",
"Cortizone 10 Itch Relief Massaging Rollerball",
"Cortizone 10 Overnight Itch Relief",
"Cortizone 10 Plus",
"Cortizone 10 Poison Ivy Relief Pads",
"Cortizone 10 Sensitive Skin Anti-itch Creme",
"Cortizone 10 Ultra Soothing Creme",
"Cortizone 10 Water Resistant",
"Cortizone-10 Soothing Aloe Creme",
"Cortomycin",
"Cortomycin",
"Cortomycin",
"Crane Safety Hydrocortisone",
"Crane Safety Hydrocortisone",
"CVS Anti itch",
"CVS Anti-Itch Hydrocortisone",
"CVS Cools Itch Fast",
"CVS Cortisone",
"CVS Health Hydrocortisone Anti Itch",
"CVS Health Maxium Strentgh Cortisone",
"Cvs Hydrocortisone With Aloe",
"CVS Maximum Strength Anti-Itch Cream",
"CVS Maximum Strength Feminine Anti-Itch Cream",
"CVS Pharmacy Anti-itch",
"DermaCort Anti-itch",
"Dermaquest Skin Therapy Post-Skin Resurfacing Balm",
"Dermarest Dricort 0.5% Hydrocortisone Anti-itch",
"Dermarest Eczema Medicated",
"Dermasorb AF Complete Kit",
"Dermazene",
"Dermoscribe Ichybum",
"Dermoscribe Seborrheic Dermatitis",
"DG Health Hydrocortisone",
"DG health hydrocortisone",
"Dg Health Hydrocortisone",
"DG Health Hydrocortisone Maximum Strength",
"Discount Drug Mart Anti-itch",
"Dr H Stabilizer",
"Dr Lift Soothing Cream",
"Dr. Sheffield Hydrocortisone Anti itch",
"Dr. Throwers Hydrotet",
"Duane Reade",
"Duane Reade hydrocortisone",
"Duane Reade hydrocortisone plus 12 moisturizers",
"ECOLAB Hydrocortisone Cream",
"Eczema Skin Mushatts N9",
"Efmody",
"Efmody",
"Efmody",
"Efmody",
"Efmody",
"Emo Cort Cream 2.5%",
"Emo Cort Lotion 2.5%",
"Emo Cort Sol 2.5% USP",
"Equaline Anti Itch",
"Equaline Anti Itch",
"Equaline Anti Itch Maximum Strength",
"Equaline Anti Itch Maximum Strength",
"Equate Hydrocortisone",
"Equate Hydrocortisone",
"Equate Hydrocortisone",
"Equate Hydrocortisone",
"Equate Hydrocortisone",
"Equate Hydrocortisone Intensive Healing Formula",
"Equate Hydrocortisone Topical",
"Exchange Select Hydrocortisone",
"Face Values Hydrocortisone With Aloe",
"Family Care Anti-Itch",
"Family Care Anti-Itch",
"Family Care Hydrocortisone",
"Family Care Hydrocortisone",
"Family Wellness",
"Family Wellness",
"Family Wellness Hydrocortisone",
"Family Wellness Max Strength 1 Hydrocortisone Cream",
"Family Wellness Maximum Strength Hydrocortisone",
"First Aid Only Hydrocortisone 1% Anti-Itch",
"FIRST Dukes Mouthwash Compounding",
"FIRST Marys Mouthwash Compounding",
"FixMySkin Healing Balm Fragrance-Free",
"FixMySkin Healing Balm Unflavored",
"FixMySkin Healing Balm Vanilla Flavor",
"FixMySkin Healing Balm Vanilla Flavor",
"FixMySkin Healing Balm Vanilla Fragrance",
"FixMySkin HEALING BODY BALM Fragrance-Free",
"FixMySkin HEALING LIP BALM unflavoured",
"Formu Care Anti Itch maximum strength",
"Freds Hydrocortisone Plus 12 Moisturizers",
"Freds Hydrocortisone with Aloe",
"Fulton Street Market Anti itch",
"Gelmicin Hydrocortisone with Aloe",
"glo SKIN BEAUTY Remedy Gel",
"Glytone soothe calming",
"Good Neighbor Pharmacy Anti Itch",
"Good Neighbor Pharmacy Hydrocortisone",
"Good Neighbor Pharmacy Hydrocortisone Plus 12 Moisturizers",
"Good Neighbor Pharmacy Hydrocortisone with Aloe",
"Good Neighbor Pharmacy Hydrocortisone With Aloe for Sensitive Skin",
"Good Sense Anti Itch",
"Good Sense Anti Itch",
"Good Sense Anti Itch",
"Good Sense Anti Itch",
"Green Guard Maximum Strength Hydrocortisone",
"H Plus Holdings Nourishing",
"H Plus Holdings Nourishing",
"H-Releve Anti-Itch",
"Harris Teeter Anti-Itch",
"Harris Teeter Anti-Itch Cooling Relief",
"Harris Teeter Anti-Itch Intensive Healing",
"Harris Teeter Anti-Itch with Aloe",
"Harris Teeter Maximum Strength Anti-Itch",
"Healerz for Itches",
"Healing Tree Calming Anti-itch",
"Health Mart Pharmacy Hydrocortisone Maximum Strength Plus 12 Moisturizers",
"Health Mart Pharmacy Hydrocortisone Maximum Strength with Aloe",
"Healthy Accents Cortisone Maximum Strength",
"HEM-EASY RELIEF Herbal Anti-Itch MAXIMUM ITCH RELIEF",
"Hemorrodil Unguento Plus",
"Herb Street Anti-Itch Stick",
"HeXashield Anti Itch Cream with Healing Aloe",
"Home PapKit",
"Hycort Retention Enema 100mg/60ml",
"Hydro Ear",
"Hydro Skin",
"Hydrocaine",
"Hydrocort",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone",
"Hydrocortisone 0.5% / Hydroquinone 4% / Tretinoin 0.025%",
"Hydrocortisone 0.5% / Hydroquinone 4% / Tretinoin 0.025%",
"Hydrocortisone 0.5% / Hydroquinone 4% / Tretinoin 0.025%",
"Hydrocortisone 0.5% / Hydroquinone 4% / Tretinoin 0.025%",
"Hydrocortisone 0.5% / Hydroquinone 6%",
"Hydrocortisone 0.5% / Hydroquinone 6% / Tretinoin 0.025%",
"Hydrocortisone 0.5% / Hydroquinone 6% / Tretinoin 0.025%",
"Hydrocortisone 0.5% / Hydroquinone 6% / Tretinoin 0.05%",
"Hydrocortisone 0.5% / Hydroquinone 8% / Tretinoin 0.025%",
"Hydrocortisone 0.5% / Hydroquinone 8% / Tretinoin 0.025%",
"Hydrocortisone 0.5% / Hydroquinone 8% / Tretinoin 0.05%",
"Hydrocortisone 1",
"Hydrocortisone 1 Plus 10",
"Hydrocortisone 1%",
"Hydrocortisone 1%",
"Hydrocortisone 1%",
"Hydrocortisone 1%",
"Hydrocortisone 1%",
"Hydrocortisone 1%",
"Hydrocortisone 1%",
"Hydrocortisone 1%",
"Hydrocortisone 1%",
"Hydrocortisone 1% / Hydroquinone 8% / Tretinoin 0.05%",
"Hydrocortisone 1% in Absorbase",
"Hydrocortisone 1% in Absorbase",
"Hydrocortisone 1% in Absorbase",
"Hydrocortisone 1% with healing aloe",
"Hydrocortisone 2.5% / Hydroquinone 4% / Tretinoin 0.025%,",
"Hydrocortisone 2.5% / Iodoquinol 1% / Ketoconazole 2%",
"Hydrocortisone 2.5% / Ketoconazole 2%",
"Hydrocortisone 2.5% / Levocetirizine Dihydrochloride 2%",
"Hydrocortisone and Acetic Acid",
"Hydrocortisone and Acetic Acid",
"Hydrocortisone and Acetic Acid",
"Hydrocortisone and Acetic Acid",
"Hydrocortisone and Acetic Acid",
"Hydrocortisone and Acetic Acid",
"Hydrocortisone and Acetic Acid",
"Hydrocortisone Anti Itch",
"Hydrocortisone Anti-Itch",
"Hydrocortisone Anti-Itch",
"Hydrocortisone anti-itch plus",
"Hydrocortisone Butyrate",
"Hydrocortisone Continuous",
"Hydrocortisone Cream",
"Hydrocortisone Cream",
"Hydrocortisone Cream",
"Hydrocortisone Cream 0.5%",
"Hydrocortisone Cream 0.5%",
"Hydrocortisone Cream 0.5% USP",
"Hydrocortisone Cream 1%",
"Hydrocortisone Cream 1%",
"Hydrocortisone Cream 1% with Aloe Vera",
"Hydrocortisone Cream Intensive Healing",
"Hydrocortisone Cream USP 0.5%",
"Hydrocortisone Crm 0.5%",
"Hydrocortisone Crm 1%",
"Hydrocortisone D",
"Hydrocortisone HC",
"HydroCortisone Intensive Healing Formula",
"Hydrocortisone Intensive Healing Formula",
"Hydrocortisone Iodoquinol",
"hydrocortisone Iodoquinol",
"Hydrocortisone Iodoquinol",
"Hydrocortisone Iodoquinol",
"Hydrocortisone Iodoquinol",
"Hydrocortisone Maximum Strength",
"Hydrocortisone Maximum Strength",
"Hydrocortisone Maximum Strength",
"Hydrocortisone Maximum Strength",
"Hydrocortisone Maximum Strength",
"Hydrocortisone Maximum Strength",
"Hydrocortisone Maximum Strength",
"Hydrocortisone maximum strength",
"Hydrocortisone Maximum Strength",
"Hydrocortisone Maximum Strength",
"Hydrocortisone Maximum Strength",
"Hydrocortisone maximum strength",
"Hydrocortisone Maximum Strength",
"Hydrocortisone Maximum Strength",
"Hydrocortisone Maximum Strength",
"Hydrocortisone Maximum Strength",
"Hydrocortisone Maximum Strength",
"Hydrocortisone Maximum Strength",
"Hydrocortisone Maximum Strength",
"Hydrocortisone Maximum Strength",
"Hydrocortisone Maximum Strength",
"Hydrocortisone Maximum Strength",
"Hydrocortisone Maximum Strength",
"Hydrocortisone Maximum Strength",
"Hydrocortisone Maximum Strength",
"Hydrocortisone Maximum Strength",
"Hydrocortisone Maximum Strength",
"Hydrocortisone Maximum Strength",
"Hydrocortisone Maximum Strength",
"Hydrocortisone Maximum Strength",
"Hydrocortisone Maximum Strength with Aloe",
"Hydrocortisone Maximum Strength with Aloe",
"Hydrocortisone Maximum Strength with aloe",
"Hydrocortisone Maximum Strength with aloe",
"Hydrocortisone Micro",
"Hydrocortisone Ointment 0.5%",
"Hydrocortisone Ointment 1%",
"Hydrocortisone Plus",
"Hydrocortisone Plus 10 Moisturizers",
"Hydrocortisone Plus 12 Moisturizers",
"Hydrocortisone Plus 12 Moisturizers",
"Hydrocortisone Plus 12 Moisturizers",
"Hydrocortisone Plus 12 Moisturizers Maximum Strength",
"Hydrocortisone Plus 12 Moisturizers Maximum Strength",
"Hydrocortisone Plus 12 Moisturizers Maximum Strength",
"Hydrocortisone Rectal Suspension (Retention)",
"Hydrocortisone Regular Strength",
"Hydrocortisone Ultra Strength",
"Hydrocortisone with Aloe",
"Hydrocortisone With Aloe",
"Hydrocortisone with Aloe",
"Hydrocortisone with Aloe",
"Hydrocortisone with Aloe",
"Hydrocortisone with aloe",
"Hydrocortisone with Aloe Maximum Strength",
"Hydrocortisone With Aloe Maximum Strength",
"Hydrocortisone with Aloe Maximum Strength",
"Hydrocortisone with Aloe Maximum Strength",
"Hydrocortisone with Aloe Maximum Strength",
"Hydrocortisone with Aloe Maximum Strength",
"Hydrocortisone With Aloe Maximum Strength",
"Hydrocortisone with Aloe Maximum Strength",
"Hydrocortisone, Iodoquinol",
"HydrocortisoneLotion",
"HydroSKIN",
"HydroSkin",
"Hydroxate Gel",
"Hydroxym",
"Hydroxym Cream",
"Hytone",
"Hytone",
"Hytone",
"Insect Bite Relief",
"Instant Cooling Itch Relief",
"Instant Cooling Itch Relief CVS",
"Intensive Healing Anti Itch",
"Intensive Healing Eczema",
"Itch and Bite Relief First Aid Kit",
"Itch and Bite Relief First Aid Kit",
"Itch and Rash Cream",
"Itch Fixer",
"Itch Relief",
"Itch Relief",
"Itch relief Cream",
"Itch Stuff",
"KAISER PERMANENTE Hydrocortisone",
"Kera HC",
"Ketocon",
"Kirkland Signature Hydrocortisone Plus Maximum Strength",
"Leader Hydrocortisone",
"Leader Hydrocortisone",
"Leader Hydrocortisone With Aloe",
"Leader Hydrocortisone With Aloe",
"Live Better Hydrocortisone with Aloe",
"Loesch Anti-Itch Therapy",
"Loesch HC-10 ANTI-ITCH THERAPY",
"Lucky SuperSoft MAXIMUM STRENGTH",
"Lucky SuperSoft MAXIMUM STRENGTH",
"Makesense Maximum Strength",
"Market Basket Anti-Itch Cream Plus",
"Maximum Strength Anti-Itch",
"Maximum Strength Cortisone",
"Maximum Strength Cortisone Cream with Aloe",
"Maximum Strength Cortizone 10 Quick Shot 360 Continuous",
"Maximum Strength Gold Bond Medicated Anti-itch Cream Intensive Formula",
"Maximum Strength Hydrocortisone",
"Maximum Strength Hydrocortisone",
"Maximum Strength Hydrocortisone Cream",
"Maximum Strength Hydrocortisone Cream with Aloe",
"Maximum Strength Hydrocortisone Plus Moisturizing Aloe",
"Maximum-H",
"Medi-Cortisone with Aloe",
"Medi-First",
"Medi-First Hydrocortisone",
"Medi-First Plus Hydrocortisone",
"Meijer Anti Itch",
"Meijer Anti Itch Cream Plus",
"Meijer Anti-itch with Aloe",
"meijer Hydrocortisone",
"meijer Hydrocortisone Plus 12 Moisturizers",
"Meijer Intense Healing",
"meijer Itch and Rash Relief",
"Meijer Max. Strength Anti-Itch Cream Intensive Healing Formula",
"Meijer Maximum Strength Anti-itch",
"Meijer Maximum Strength Anti-itch Cream Ultra Moisturizing Formula 1oz",
"Meijer Maximum Strength Anti-itch Cream wiith Aloe",
"Meijer Maximum Strength Anti-itch Cream with Aloe",
"Members Mark Hydrocortisone",
"Members Mark Hydrocortisone",
"Monistat Complete Care Instant Itch Relief",
"Monistat Soothing Care Itch Relief",
"Mycozyl HC",
"Mycozyl HC Cream Gel",
"Natureplex Hydrocortisone Hydro",
"NeilMed Anti-Itch",
"Neo-poly-bac Hydro",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"NEOMYCIN and POLYMYXIN B SULFATES and HYDROCORTISONE",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone Otic Suspension",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone Otic Suspension",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone Otic Suspension",
"Neomycin and Polymyxin B Sulfates, Bacitracin Zinc and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates, Bacitracin Zinc and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates, Bacitracin Zinc and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates, Bacitracin Zinc and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates, Bacitracin Zinc, and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates, Bacitracin Zinc, and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates, Bacitracin Zinc, and Hydrocortisone",
"Neomycin, Polymyxin B Sulfates and Hydrocortisone",
"Neosporin Eczema Essentials Anti Itch",
"Neosporin Essentials Trial Pack",
"Nizoral Scalp Itch Relief",
"NU-DERM Tolereen Anti-pruritic",
"Odan Proctomyxin HC",
"Odan Proctomyxin HC Suppositories",
"Odan-spor-HC",
"OLIVIA QUIDO FIRM and FADE I",
"OLIVIA QUIDO FIRM and FADE II",
"OLP Hydrocortisone 1%",
"OREAD GOLD Anti-Itch Foam",
"Oti Rx",
"Oticin HC Ear Drops",
"Oto End 10",
"Our Family Hydrocortisone with Aloe",
"Pediaderm HC",
"Pediadermics Eczema 2",
"Pediotic",
"Petrocort Antipruritic Lip 21",
"Pharmaskincare Acnecare Cream",
"Pharmaskincare Brightening Dermarelief Cream",
"Pharmaskincare Multi-Gly Skin Relief Cream",
"Piyanping antiitch",
"Plenadren",
"Plenadren",
"Plenadren",
"Plenadren",
"Poison Oak",
"Poison Oak and Ivy",
"Post peel Protectant Vitality Institute",
"Post peel Protectant Vitality Institute",
"Post peel Protectant Vitality Institute",
"Post Treatment Balm",
"Post-Treatment Repair Cream",
"Post-Treatment Repair Cream",
"Pramoxine-HC",
"Pramoxine-HC",
"Premier Value Hydrocortisone",
"Premier Value Hydrocortisone Plus 12 Moisturizers",
"Preparation H Hydrocortisone",
"Preparation H Soothing Relief Anti-itch",
"Proactiv Solution Anti-Itch Scalp",
"Procto-Med HC",
"Procto-Med HC",
"Procto-Med HC",
"Procto-Med HC",
"Procto-Med HC",
"Procto-Pak",
"Proctocort",
"Proctocream HC",
"Proctol Ointment",
"Proctol Suppositories",
"Proctosedyl",
"Proctosedyl",
"Proctosedyl Ointment",
"Proctosedyl Ointment",
"Proctosedyl Sup",
"Proctosedyl Suppositories",
"Proctosol-HC",
"Proctosol-HC",
"Proctosol-HC",
"Proctosol-HC",
"Proctozone HC",
"Proctozone HC",
"Proctozone HC",
"Proctozone HC",
"Proctozone-HC",
"Proctozone-HC",
"Proctozone-HC",
"Proctozone-HC",
"Proctozone-HC",
"Proctozone-HC",
"ProCure Hydrocortisone Cream Plus",
"ProCure Hydrocortisone Plus Calendula",
"PS-2896 Hydrocortisone Cream 1%, 0.9g",
"Psoriasin Itch Control",
"Publix Hydro",
"Publix hydro plus",
"Quadrydern",
"Quadrydern",
"Quality Choice Anti Itch",
"Quality Choice Anti Itch",
"Quality Choice Anti Itch with Aloe",
"Quality Choice Anti-Itch",
"Quality Choice Anti-Itch",
"Quality Choice Hydrocortisone",
"Quality Choice Hydrocortisone Maximum Strength",
"Quality Choice Itch Relief",
"Quality Choice Maximum Strength Anti Itch",
"Quatriderm Anti-itch",
"Quatriderm Creme Nf",
"Refuge HC",
"Regular Strength Hydrocortisone Cream",
"Rephresh Cooling",
"Rephresh Cooling",
"Rephresh Cooling",
"Rexall Anti Itch Maximum Strength Relief",
"Rexall Hydrocortisone 1",
"Rexall Hydrocortisone Plus Moisturizers",
"Rite Aid anti-itch",
"Rite Aid Cortisone",
"Rodan and Fields Soothe",
"Rugby Hydrocortisone With Aloe",
"Rugby Hydrocortisone With Aloe",
"Rugby Hydroskin",
"S-Cream HYDROCORTISONE 1%",
"S-Oint HYDROCORTISONE 1%",
"SAFEWAY Hydrocortisone Plus 12 Moisturizers",
"Sandoz Cortimyxin",
"Sandoz Cortimyxin",
"Sandoz Hydrocortisone",
"Sarna HC",
"Sarna Whipped Foam",
"Scalpicin Anti-Itch Maximum Strength",
"Scalpicin Maximum Strength",
"Scalpicin Scalp Itch Medication Maximum Strength",
"Scarguard MD",
"Scarguard MD Physicians Formula",
"Schein Hydrocortisone",
"SeaCalm Skin Itch Relief Instant Cooling",
"Selsun Blue Scalp Itch Treatment",
"Shopko Hydrocortisone",
"Shopko Hydrocortisone",
"Shopko Hydrocortisone Intensive Healing Formula",
"Shopko Hydrocortisone Maximum Strength",
"Shopko Hydrocortisone Plus 12 Moisturizers Maximum Strength",
"Shopko Hydrocortisone With Aloe",
"Shopko Maximum Strength",
"ShopRite Hydrocortisone",
"Shoprite Hydrocortisone",
"Signature Care Anti Itch",
"signature care Hydrocortisone",
"Signature Care Hydrocortisone",
"Signature Care Hydrocortisone",
"Signature Care Hydrocortisone",
"SKIN A COOL Hydrocortisone Anti-Itch",
"Smart Sense Anti Itch",
"Smart Sense Anti Itch",
"Smart Sense Anti Itch",
"Smart Sense Anti Itch Maximum Strength",
"Smart Sense Hydrocortisone",
"Smart Sense Hydrocortisone",
"Smart sense Hydrocortisone",
"Smart Sense Hydrocortisone",
"Smart sense Hydrocortisone",
"Soothe Rodan Fields",
"Sterex Crm Plus",
"Sterex Lot Plus",
"sunmark Hydrocortisone",
"Sunmark Hydrocortisone Plus",
"Sunmark Hydrocortisone with Aloe Maximum Strength",
"Sunmark Hydrocortisone with Aloe Maximum Strength",
"Tecnu Corticool",
"Texacort",
"Texacort",
"Texacort Solution 1%",
"Thera Plus",
"Thera plus Anti-itch with aloe Hydrocortisone",
"TheraCare Hydrocortisone Cream",
"TheraCare Maximum Strength 1% Hydrocortisone",
"Theracort",
"Theraplex AIM Anti-Itch Moisturizing Cream",
"Ti-U-lac HC Lotion",
"TopCare Hydrocortisone",
"Topcare Hydrocortisone",
"Topcare Hydrocortisone",
"Topcare Hydrocortisone",
"Topcare Hydrocortisone",
"TopCare Hydrocortisone 1% with Aloe",
"TopCare Hydrocortisone Intensive Healing Formula",
"TopCare Hydrocortisone Plus 12 Moisturizers",
"Total Relief",
"Triple Antibiotic HC",
"TrueLipids 1% Hydrocortisone Barrier Cream",
"TrueLipids Anti-Itch Barrier",
"UEC Medical Anti-Itch",
"Up and Up Anti Itch",
"Up and Up Anti Itch",
"Up and Up Anti Itch",
"Up and Up anti itch",
"Up and Up anti itch maximum strength",
"Up and Up Hydrocortisone",
"Up and Up Hydrocortisone",
"Up and Up Hydrocortisone",
"Up and Up Hydrocortisone Anti Itch",
"Up and Up Hydrocortisone One Per Cent",
"Up and Up Intensive Healing",
"Vanoxide HC",
"Viniferamine Hydrocortisone Cream",
"Vioform + Hydrocortisone",
"Vioform Hydrocortisone",
"Vioform Hydrocortisone Mild",
"Vosol HC",
"Walgreens Hydrocortisone Plus 12 Moisturizers",
"Weeks and Leo Anti-itch",
"Welly Adventure First Aid Kit",
"Welly Excursion First Aid Kit",
"Welly First Aid Kit",
"Welly Human Repair Kit",
"Welly Itch Fix",
"Welly Superhero Supplies Kit",
"Western Family HydroCortisone",
"Western Family HydroCortisone Plus 12 Moisturizers",
"WinCo Foods Hydrocortisone Cream Intensive Healing",
"WINCO Hydrocortisone",
"WinCo Maximum Strength Hydrocortisone",
"WinCo Maximum Strength Hydrocortisone",
"Winco Maximum Strength Hydrocortisone",
"Xerese",
"Xerese",
"Xerese",
"Xpect Hydrocortisone",
"Yes To Coconut Eczema Relief",
"Zims Advanced Crack Creme With Hydrocortisone",
"Zims Advanced Hydrocortisone Continuous With Organic Arnica and Aloe"
] |
[
"Acticort",
"Aeroseb HC",
"Ala-Scalp",
"Algicirtis",
"Beta-HC",
"Cetacort",
"Cortaid",
"Delacort",
"Ficortril",
"Genacort",
"Glycort",
"Komed HC",
"Lacticare HC",
"Lubricort",
"Meusicort",
"Mildison",
"Nogenic HC",
"Nutracort",
"Penecort",
"Permicort",
"Polcort H",
"Preparation H Hydrocortisone Cream",
"Prevex HC",
"Proctocream",
"Remederm HC",
"Sanatison",
"Scalpicin Capilar",
"Schericur",
"Sigmacort",
"Synacort",
"Systral Hydrocort",
"Timocort"
] |
[
"Alcortin",
"Cipro",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Cipro HC",
"FIRST Dukes Mouthwash Compounding",
"FIRST Marys Mouthwash Compounding",
"Neomycin and Polymyxin B Sulfates, Bacitracin Zinc and Hydrocortisone",
"Triple Antibiotic HC",
"Neo-poly-bac Hydro",
"Scarguard MD",
"Scarguard MD Physicians Formula",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Oti Rx",
"Ketocon",
"Bencort",
"NEOMYCIN and POLYMYXIN B SULFATES and HYDROCORTISONE",
"Cortisporin",
"Pediotic",
"Cortisporin",
"Neomycin, Polymyxin B Sulfates and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Pramoxine-HC",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Xerese",
"Acetasol HC",
"Hydro Ear",
"Cortisporin",
"Antibiotic Ear (Neo/Polym/HC)",
"Cortaine -B Aqueous",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Hydrocortisone Iodoquinol",
"Cortisporin",
"Poison Oak",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Oto End 10",
"Oticin HC Ear Drops",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Dr. Throwers Hydrotet",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Cortisporin",
"Pramoxine-HC",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Neosporin Essentials Trial Pack",
"Neomycin and Polymyxin B Sulfates, Bacitracin Zinc and Hydrocortisone",
"Hydrocortisone and Acetic Acid",
"Cortisporin Ophthalmic",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates, Bacitracin Zinc and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Dermazene",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates, Bacitracin Zinc, and Hydrocortisone",
"Cortane-B",
"Neomycin and Polymyxin B Sulfates, Bacitracin Zinc, and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Dermasorb AF Complete Kit",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Cortomycin",
"Cortomycin",
"Cortomycin",
"Cortisporin",
"Neomycin and Polymyxin B Sulfates, Bacitracin Zinc, and Hydrocortisone",
"Hydrocortisone and Acetic Acid",
"Hydrocortisone and Acetic Acid",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Hydrocortisone, Iodoquinol",
"hydrocortisone Iodoquinol",
"Vanoxide HC",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Hydrocortisone Iodoquinol",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Welly Superhero Supplies Kit",
"Welly Human Repair Kit",
"Dermoscribe Seborrheic Dermatitis",
"Dermoscribe Ichybum",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Hydrocortisone 0.5% / Hydroquinone 8% / Tretinoin 0.025%",
"Hydrocortisone 0.5% / Hydroquinone 6% / Tretinoin 0.025%",
"Hydrocortisone 0.5% / Hydroquinone 6% / Tretinoin 0.025%",
"Hydrocortisone 0.5% / Hydroquinone 8% / Tretinoin 0.025%",
"Hydrocortisone 0.5% / Hydroquinone 4% / Tretinoin 0.025%",
"Hydrocortisone 0.5% / Hydroquinone 4% / Tretinoin 0.025%",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Clindamycin 1% / Hydrocortisone 2.5% / Niacinamide 4%",
"Hydrocortisone 2.5% / Levocetirizine Dihydrochloride 2%",
"Hydrocortisone 2.5% / Ketoconazole 2%",
"Hydrocortisone 2.5% / Iodoquinol 1% / Ketoconazole 2%",
"Hydrocortisone 2.5% / Hydroquinone 4% / Tretinoin 0.025%,",
"Hydrocortisone 0.5% / Hydroquinone 4% / Tretinoin 0.025%",
"Hydrocortisone 0.5% / Hydroquinone 4% / Tretinoin 0.025%",
"Hydrocortisone 0.5% / Hydroquinone 8% / Tretinoin 0.05%",
"Hydrocortisone 0.5% / Hydroquinone 6%",
"Hydrocortisone 1% / Hydroquinone 8% / Tretinoin 0.05%",
"Hydrocortisone 0.5% / Hydroquinone 6% / Tretinoin 0.05%",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Cipro HC",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"OLIVIA QUIDO FIRM and FADE I",
"Casporyn HC",
"OLIVIA QUIDO FIRM and FADE II",
"Cho-A Care Lot 1%",
"Itch and Bite Relief First Aid Kit",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Ala Quin",
"Neomycin and Polymyxin B Sulfates, Bacitracin Zinc and Hydrocortisone",
"Hydrocortisone and Acetic Acid",
"Xerese",
"Cipro HC",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Hydrocortisone Iodoquinol",
"Welly Adventure First Aid Kit",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Hydrocortisone and Acetic Acid",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Acetasol HC",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone Otic Suspension",
"141017 Hydrocortisone 0.5% / Hydroquinone 6% / Tretinoin 0.025%",
"141016 Hydrocortisone 0.5% / Hydroquinone 4% / Tretinoin 0.025%",
"141061 Hydrocortisone 0.5% / Hydroquinone 8% / Tretinoin 0.025%",
"141060 Hydrocortisone 0.5% / Hydroquinone 4% / Tretinoin 0.025%",
"Welly Excursion First Aid Kit",
"Itch and Bite Relief First Aid Kit",
"Hydrocortisone Iodoquinol",
"Welly First Aid Kit",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone Otic Suspension",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Corti-Sav",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Vioform Hydrocortisone",
"Xerese",
"Cortisporin",
"Proctosedyl Sup",
"Proctosedyl Suppositories",
"Calmurid HC Crm",
"Ti-U-lac HC Lotion",
"Proctosedyl Ointment",
"Proctosedyl Ointment",
"Sterex Crm Plus",
"Sterex Lot Plus",
"Vioform + Hydrocortisone",
"Vioform Hydrocortisone Mild",
"Maximum Strength Gold Bond Medicated Anti-itch Cream Intensive Formula",
"Odan-spor-HC",
"Proctosedyl",
"Odan Proctomyxin HC",
"Proctol Ointment",
"Odan Proctomyxin HC Suppositories",
"Proctol Suppositories",
"Proctosedyl",
"Cortisporin",
"Cortisporin",
"Cipro HC Otic Suspension",
"Cortisporin",
"Sandoz Cortimyxin",
"Sandoz Cortimyxin",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Corti-Sav",
"Cipro HC",
"Alumier MD Post Procedure Kit with Hydrocortisone",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Cipro HC",
"Cipro HC",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone Otic Suspension",
"Poison Oak and Ivy",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Mycozyl HC",
"Hydrocortisone and Acetic Acid",
"Hydrocortisone and Acetic Acid",
"Mycozyl HC Cream Gel",
"Vosol HC",
"Hydrocaine",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Cipro HC",
"Neomycin and Polymyxin B Sulfates and Hydrocortisone",
"Cipro HC"
] |
[
"P04150",
"P04083"
] |
[
"P08684",
"P20815",
"P24462",
"P15538",
"P19099",
"P10632",
"P51857",
"P31213",
"P80365",
"P28845",
"P11509",
"Q16678",
"P20813",
"P11712",
"P33261"
] |
[
"P04278",
"P08185"
] |
[
"P08183",
"P46721",
"Q8TCC7"
] |
DB04652
|
Corticosterone
|
An adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid. (From Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1437)
|
solid
| null | null | null | null | null | null | null | null | null | null | null |
Organic compounds
|
Lipids and lipid-like molecules
|
Steroids and steroid derivatives
|
Hydroxysteroids
|
[
"experimental"
] |
[] |
[] |
[] |
[] |
(11β)-11,21-dihydroxypregn-4-ene-3,20-dione | 11beta,21-Dihydroxy-4-pregnene-3,20-dione | 11β,21-dihydroxyprogesterone | 17-deoxycortisol | Kendall's compound B | Reichstein's substance H | 1.1.1.146 | 11-beta-HSD1 | 11-DH | 7-oxosteroid reductase | Corticosteroid 11-beta-dehydrogenase isozyme 1 | HSD11 | HSD11L | SDR26C1 | Short chain dehydrogenase/reductase family 26C member 1 | GR | GRL | Nuclear receptor subfamily 3 group C member 1 | 2.3.1.48 | BHLHE74 | Class E basic helix-loop-helix protein 74 | NCoA-1 | Protein Hin-2 | Renal carcinoma antigen NY-REN-52 | RIP160 | SRC-1 | SRC1 | Steroid receptor coactivator 1 | MCR | MLR | MR | Nuclear receptor subfamily 3 group C member 2 | 1,4-cineole 2-exo-monooxygenase | 1,8-cineole 2-exo-monooxygenase | 1.14.14.1 | Albendazole monooxygenase (sulfoxide-forming) | Albendazole sulfoxidase | Cholesterol 25-hydroxylase | CYP3A3 | CYPIIIA3 | CYPIIIA4 | Cytochrome P450 3A3 | Cytochrome P450 HLp | Cytochrome P450 NF-25 | Cytochrome P450-PCN1 | Nifedipine oxidase | Quinine 3-monooxygenase | 1.1.1.146 | 11-beta-HSD1 | 11-DH | 7-oxosteroid reductase | Corticosteroid 11-beta-dehydrogenase isozyme 1 | HSD11 | HSD11L | SDR26C1 | Short chain dehydrogenase/reductase family 26C member 1 | 1.1.1.- | 11-beta-HSD type II | 11-beta-HSD2 | 11-beta-hydroxysteroid dehydrogenase type II | 11-DH2 | 11-HSD type II | Corticosteroid 11-beta-dehydrogenase isozyme 2 | HSD11K | NAD-dependent 11-beta-hydroxysteroid dehydrogenase | SDR9C3 | Short chain dehydrogenase/reductase family 9C member 3
|
[] |
[] |
[] |
[
"P28845",
"P04150",
"Q15788",
"P08235"
] |
[
"P08684",
"P28845",
"P80365"
] |
[] |
[] |
DB04704
|
20-hydroxycholesterol
| null |
solid
| null | null | null | null | null | null | null | null | null | null | null |
Organic compounds
|
Lipids and lipid-like molecules
|
Steroids and steroid derivatives
|
Cholestane steroids
|
[
"experimental"
] |
[] |
[] |
[] |
[] |
[] |
[] |
[] |
[] |
[] |
[] |
[] |
|
DB00397
|
Phenylpropanolamine
|
Phenylpropanolamine is a sympathomimetic agent that acts as a nonselective adrenergic receptor agonist and norepinephrine reuptake inhibitor. It has been used as a decongestant and appetite suppressant. Currently, it is withdrawn from the market in Canada and the United States due to the risk for hemorrahgic strokes.
|
solid
|
For the treatment of nasal congestion, control of urinary incontinence, priapism and obesity.
|
Phenylpropanolamine (PPA), a sympathomimetic agent structurally similar to pseudoephedrine, is used to treat nasal congestion. Phenylpropanolamine is found in appetite suppressant formulations and with guaifenesinin in cough-cold formulations. In 2000, the FDA requested that all drug companies discontinue marketing products containing phenylpropanolamine, due to an increased risk of hemorrhagic stroke in women who used phenylpropanolamine.
|
Phenylpropanolamine acts directly on alpha- and, to a lesser degree, beta-adrenergic receptors in the mucosa of the respiratory tract. Stimulation of alpha-adrenergic receptors produces vasoconstriction, reduces tissue hyperemia, edema, and nasal congestion, and increases nasal airway patency. PPA indirectly stimulates beta-receptors, producing tachycardia and a positive inotropic effect.
|
Reduced bioavailability (about 38%) from gastrointestinal tract because of first pass metabolism by monoamine oxidase in the stomach and liver.
|
Hepatic
|
May induce ventricular extrasystoles and short paroxysms of ventricular tachycardia, a sensation of fullness in the head and tingling of the extremities; LD<sub>50</sub>=1490mg/kg (orally in rat)
|
2.1 to 3.4 hours.
| null | null | null | null | null | null | null | null |
[
"approved",
"vet_approved",
"withdrawn"
] |
[
"R01BA",
"R01B",
"R01",
"R",
"R01BA",
"R01B",
"R01",
"R"
] |
[
"Humans and other mammals"
] |
[
{
"cost": "1.14",
"description": "Entex ER 10-300 mg 12 Hour Capsule",
"unit": "capsule"
},
{
"cost": "15.99",
"description": "Naldecon Senior EX 200 mg/5ml Syrup 118ml Bottle",
"unit": "bottle"
},
{
"cost": "0.04",
"description": "Triaminic chest-nasal cong liq",
"unit": "ml"
},
{
"cost": "0.04",
"description": "Triaminic cold & cough liquid",
"unit": "ml"
},
{
"cost": "0.04",
"description": "Triaminic cold-allergy pe liq",
"unit": "ml"
},
{
"cost": "0.04",
"description": "Triaminic cough-nasal cong liquid",
"unit": "ml"
},
{
"cost": "0.04",
"description": "Triaminic cough-sore throat liquid",
"unit": "ml"
},
{
"cost": "0.04",
"description": "Triaminic flu cough-fever suspension",
"unit": "ml"
},
{
"cost": "0.04",
"description": "Triaminic flu-cough-fever liquid",
"unit": "ml"
},
{
"cost": "0.04",
"description": "Triaminic-d syrup",
"unit": "ml"
},
{
"cost": "0.05",
"description": "Apap allergy sinus caplet",
"unit": "caplet"
},
{
"cost": "0.06",
"description": "Naldecon-dx senior",
"unit": "ml"
},
{
"cost": "0.16",
"description": "Codimal dm syrup",
"unit": "ml"
},
{
"cost": "0.18",
"description": "Codimal DH 5-8.33-1.66 mg/5ml Syrup",
"unit": "ml"
},
{
"cost": "0.18",
"description": "Despec-exp syrup",
"unit": "ml"
},
{
"cost": "0.19",
"description": "Dexatrim natural caplet",
"unit": "caplet"
},
{
"cost": "0.23",
"description": "Triaminicin tablet",
"unit": "tablet"
},
{
"cost": "0.24",
"description": "Childrens triaminic decon spray",
"unit": "ml"
},
{
"cost": "0.25",
"description": "Triaminic softchews tablet",
"unit": "tablet"
},
{
"cost": "0.27",
"description": "Triaminic cough-cold chew",
"unit": "each"
},
{
"cost": "0.27",
"description": "Triaminic softchew tablet",
"unit": "tablet"
},
{
"cost": "0.3",
"description": "Triaminic cgh-runny nose strip",
"unit": "strip"
},
{
"cost": "0.3",
"description": "Triaminic cough strips",
"unit": "strip"
},
{
"cost": "0.33",
"description": "Conex tablet",
"unit": "tablet"
},
{
"cost": "0.35",
"description": "Triaminic allergy thin strip",
"unit": "strip"
},
{
"cost": "0.35",
"description": "Triaminic cold-stuff nose strip",
"unit": "strip"
},
{
"cost": "0.47",
"description": "Despec-tab tablet",
"unit": "tablet"
},
{
"cost": "0.61",
"description": "Despec-dm tablet",
"unit": "tablet"
},
{
"cost": "0.7",
"description": "Codimal la capsule",
"unit": "capsule"
}
] |
[] |
(+-)-Norephedrine | (+-)-Phenylpropanolamine | Fenilpropanolamina | Norephedrine | Phenylpropanolamin | Phenylpropanolamina | Phenylpropanolamine | Phénylpropanolamine | Phenylpropanolaminum | PPA | Dopamine D1 receptor | ADRB1R | B1AR | Beta-1 adrenoceptor | Beta-1 adrenoreceptor | ADRB2R | B2AR | Beta-2 adrenoceptor | Beta-2 adrenoreceptor | ADRA2R | ADRAR | Alpha-2 adrenergic receptor subtype C10 | Alpha-2A adrenoceptor | Alpha-2A adrenoreceptor | Alpha-2AAR | ADRA2L1 | ADRA2RL1 | Alpha-2 adrenergic receptor subtype C2 | Alpha-2B adrenoceptor | Alpha-2B adrenoreceptor | Alpha-2BAR | ADRA2L2 | ADRA2RL2 | Alpha-2 adrenergic receptor subtype C4 | Alpha-2C adrenoceptor | Alpha-2C adrenoreceptor | Alpha-2CAR | 1.4.3.21 | 1.4.3.4 | MAO-A | Monoamine oxidase type A
|
[
"Antitussive Decong Antihistamine Syr",
"Bronchodex D Cap",
"Bronchosirum Pour Enfants",
"Caldomine Dh Adulte",
"Caldomine Dh Enfant",
"Centracol DM - Syr",
"Chlor Tripolon Decongest Syr",
"Cold & Allergy Relief - Liq",
"Cold Decongestant Long Acting Cap",
"Cold Relief",
"Cold Relief DM",
"Contac Cold Capsules",
"Contac Cold Extra Strength Capsules",
"Contac Cough Cold and Flu Caplets",
"Contact C Src",
"Coricidin D Long Acting Tab",
"Coricidin D Tab",
"Coricidin Nd Tab",
"Coricidin Sinus Headache Tab",
"Corsym Suspension",
"Cough, Cold & Allergy Relief",
"Counteract Sinus and Allergy",
"Decongestant Antihistaminic Syrup",
"Dilotab",
"Dimetane Expectorant Liq",
"Dimetane Expectorant-C Syr",
"Dimetane Expectorant-DC Syr",
"Dimetapp Chewable Tablets",
"Dimetapp Children's Cold & Allergy Tablets",
"Dimetapp Children's Cold & Fever",
"Dimetapp Clear",
"Dimetapp Cold & Sinus",
"Dimetapp Cough & Cold Liqui-gels - Cap",
"Dimetapp Cough, Cold & Flu",
"Dimetapp DM Elixir",
"Dimetapp DM Tab",
"Dimetapp Elixir",
"Dimetapp Extentabs",
"Dimetapp Liqui-gels Cap",
"Dimetapp Oral Infant Drops",
"Dimetapp Tab",
"Dimetapp-C Syr",
"Dristan Capsules",
"Emercidin D Tab",
"Emertabs Tab",
"Entex LA",
"Entex LA Tablets Srt",
"Extra Strength Contac C - Src",
"Hycomine",
"Hycomine",
"Oradrine 2 Tab",
"Oradrine Tablets",
"Ornade AF Liquid",
"Ornade AF Spansule Src",
"Ornade DM 10 Liq",
"Ornade DM 15 Liq",
"Ornade DM 30 Liq",
"Ornade Expectorant Cough Formula",
"Ornade Liquid",
"Ornade Spansule Src",
"Pharmacol DM Syr",
"Pharmetapp Elixir",
"Pharminicol DM Syrup",
"Sine Off Nd Extra Strength Caplet",
"Sine-off Allergy Tab",
"Sine-off N.D. Tab",
"Sine-off N.D. Tablet",
"Sinutab Sa Tab",
"Tantacol DM Syr",
"Tantapp Elixir",
"Tavist-D Tablets",
"Triaminic Cold and Allergy Syrup",
"Triaminic DM Daytime Syr",
"Triaminic Expectorant Dh Syrup",
"Triaminic Time Release Tab",
"Triaminicin Colds & Flu Caplets",
"Trisulfaminic Sus",
"Trisulfaminic Tab",
"Tussaminic C Forte Syrup",
"Tussaminic C Pediatric Syrup",
"Tussaminic Dh Forte Syrup",
"Tussaminic Dh Pediatric Syrup"
] |
[
"Acutrim",
"Boxogetten",
"Dexatrim",
"Disudrin",
"Naldec",
"Nasadec",
"Nasathera",
"Propagest",
"Recatol mono",
"Rhindecon",
"Rinexin"
] |
[
"Hycomine",
"Hycomine",
"Oradrine Tablets",
"Emercidin D Tab",
"Emertabs Tab",
"Trisulfaminic Tab",
"Dilotab",
"Trisulfaminic Sus",
"Coricidin Nd Tab",
"Triaminicin Colds & Flu Caplets",
"Pharmacol DM Syr",
"Sine Off Nd Extra Strength Caplet",
"Sinutab Sa Tab",
"Triaminic Time Release Tab",
"Tussaminic Dh Forte Syrup",
"Dimetapp Elixir",
"Dimetapp DM Elixir",
"Dimetapp Extentabs",
"Dimetapp Tab",
"Antitussive Decong Antihistamine Syr",
"Tantacol DM Syr",
"Dimetapp Oral Infant Drops",
"Dimetapp Cold & Sinus",
"Dimetapp DM Tab",
"Dimetane Expectorant-C Syr",
"Dimetane Expectorant-DC Syr",
"Entex LA Tablets Srt",
"Tussaminic C Forte Syrup",
"Tussaminic C Pediatric Syrup",
"Coricidin Sinus Headache Tab",
"Dimetapp Chewable Tablets",
"Dimetapp Liqui-gels Cap",
"Triaminic Expectorant Dh Syrup",
"Ornade AF Liquid",
"Ornade DM 10 Liq",
"Tussaminic Dh Pediatric Syrup",
"Dimetane Expectorant Liq",
"Corsym Suspension",
"Tantapp Elixir",
"Triaminic DM Daytime Syr",
"Contac Cough Cold and Flu Caplets",
"Ornade DM 30 Liq",
"Ornade Expectorant Cough Formula",
"Dimetapp Clear",
"Ornade Liquid",
"Ornade AF Spansule Src",
"Ornade DM 15 Liq",
"Centracol DM - Syr",
"Oradrine 2 Tab",
"Extra Strength Contac C - Src",
"Ornade Spansule Src",
"Cold & Allergy Relief - Liq",
"Cold Decongestant Long Acting Cap",
"Sine-off N.D. Tablet",
"Cough, Cold & Allergy Relief",
"Dimetapp Cough & Cold Liqui-gels - Cap",
"Coricidin D Tab",
"Sine-off N.D. Tab",
"Chlor Tripolon Decongest Syr",
"Contact C Src",
"Triaminic Cold and Allergy Syrup",
"Coricidin D Long Acting Tab",
"Dristan Capsules",
"Sine-off Allergy Tab",
"Caldomine Dh Adulte",
"Bronchodex D Cap",
"Dimetapp Children's Cold & Allergy Tablets",
"Contac Cold Capsules",
"Contac Cold Extra Strength Capsules",
"Counteract Sinus and Allergy",
"Entex LA",
"Cold Relief",
"Cold Relief DM",
"Caldomine Dh Enfant",
"Decongestant Antihistaminic Syrup",
"Pharminicol DM Syrup",
"Dimetapp Cough, Cold & Flu",
"Dimetapp Children's Cold & Fever",
"Pharmetapp Elixir",
"Bronchosirum Pour Enfants",
"Dimetapp-C Syr",
"Tavist-D Tablets"
] |
[
"P21728",
"P08588",
"P07550",
"P08913",
"P18089",
"P18825"
] |
[
"P21397"
] |
[] |
[] |
DB00398
|
Sorafenib
|
Sorafenib is a bi-aryl urea and an oral multikinase inhibitor. It targets cell surface tyrosine kinase receptors and downstream intracellular kinases that are implicated in tumour cell proliferation and tumour angiogenesis.[A255852] First approved by the FDA and European Commission in 2007 for the treatment of hepatocellular carcinoma, sorafenib is also indicated to treat renal carcinoma and differentiated thyroid carcinoma.[A14794]
|
solid
|
Sorafenib is indicated for the treatment of unresectable hepatocellular carcinoma and advanced renal cell carcinoma.[L9341,L44577]
In the US, it is also indicated for the treatment of patients with locally recurrent or metastatic, progressive, differentiated thyroid carcinoma that is refractory to radioactive iodine treatment.[L9341]
|
Sorafenib decreases tumour cell proliferation _in vitro_. It attenuated tumour growth of human tumour xenografts in immunocompromised mice, reduced tumour angiogenesis, and increased tumour apoptosis in models of hepatocellular carcinoma, renal cell carcinoma, and differentiated thyroid carcinoma.[A255852,L9341] Some studies suggest that sorafenib induces apoptosis in several tumour cell lines, although this effect is inconsistent across cell lines.[A255852] Antiviral effects of sorafenib have been documented, as it was shown to inhibit hepatitis C viral replication _in vitro_.[A255852]
|
Kinases are involved in tumour cell signalling, proliferation, angiogenesis, and apoptosis.[A14794,L9341] Sorafenib inhibits multiple intracellular serine/threonine kinases in the Ras/mitogen-activated protein kinase (MAPK) signal transduction pathway. Intracellular Raf serine/threonine kinase isoforms inhibited by sorafenib include Raf-1 (or C-Raf), wild-type B-Raf, and mutant B-Raf. Sorafenib inhibits cell surface tyrosine kinase receptors such as KIT, FMS-like tyrosine kinase 3 (FLT-3), RET, RET/PTC, vascular endothelial growth factor receptor-1 (VEGFR-1), VEGFR-2, VEGFR-3, and platelet-derived growth factor receptor-β (PDGFR-β).[A255852,A255857,A14794,L9341]
Sorafenib is thought to exhibit a dual mechanism of action: it blocks tumour proliferation and growth by inhibiting the RAF/MEK/extracellular signal-regulated kinase (ERK) pathway on tumour cells, and reduces tumour angiogenesis by inhibiting VEGFR and PDGFR signalling in tumour vasculature.[A255852,A10489]
|
The administration of multiple doses for seven days resulted in a 2.5- to 7-fold accumulation compared to a single dose. Steady-state concentrations were achieved within seven days, with a peak-to-trough ratio of mean concentrations of less than 2. Mean C<sub>max</sub> and AUC increased less than proportionally beyond oral doses of 400 mg administered twice daily. The T<sub>max</sub> is approximately three hours.[L9341]
The mean relative bioavailability was 38–49% following the administration of oral sorafenib tablets. A high-fat meal reduced bioavailability by 29%.[L9341]
|
Sorafenib undergoes oxidative metabolism by CYP3A4 in the liver, as well as glucuronidation by UGT1A9 in the liver and kidneys.[A255852,L9341] At steady-state, sorafenib accounts for 70-85% of the circulating analytes in plasma.[A255852] About eight metabolites of sorafenib have been identified, of which five were detected in plasma. The main circulating metabolite was the pyridine N-oxide form, which comprises approximately 9–16% of the total circulating dose at steady-state: the pharmacological activity of this metabolite was comparable to the parent drug.[L9341]
|
The oral lowest published toxic dose (Toxic Dose Low, TDLo) is 2.84 mg/kg/21D (intermittent).[L44582] The oral LD<sub>50</sub> of sorafenib tosylate in rats is >2000 mg/kg.[L44607]
The adverse reactions observed at 800 mg sorafenib twice daily (twice the recommended dose) were primarily diarrhea and dermatologic. No information is available on symptoms of acute overdose in animals because of the saturation of absorption in oral acute toxicity studies conducted in animals. The prescribing information recommends the discontinuation of sorafenib treatment and initiation of supportive care in cases of suspected overdose.[L9341]
|
The mean elimination half-life of sorafenib was approximately 25 to 48 hours.[L9341]
|
_In vitro_, sorafenib is 99.5% bound to human plasma proteins.[L9341]
|
Following oral administration of a 100 mg dose of sorafenib, about 96% of the dose was recovered within 14 days, with 77% of the dose being excreted in feces and 19% of the dose being excreted in urine as glucuronidated metabolites. Unchanged sorafenib accounted for 51% of the dose excreted in feces.[L9341]
|
Sorafenib is widely distributed to tissues, indicating that it is lipophilic.[A255852]
| null |
Organic compounds
|
Organic oxygen compounds
|
Organooxygen compounds
|
Ethers
|
[
"approved",
"investigational"
] |
[
"L01EX",
"L01E",
"L01",
"L"
] |
[
"Humans and other mammals"
] |
[
{
"cost": "66.61",
"description": "Nexavar 200 mg tablet",
"unit": "tablet"
}
] |
[
{
"approved": "2010-06-22",
"country": "Canada",
"expires": "2018-12-22",
"number": "2315715"
},
{
"approved": "2007-02-13",
"country": "Canada",
"expires": "2020-01-12",
"number": "2359510"
},
{
"approved": "2013-12-31",
"country": "United States",
"expires": "2023-02-11",
"number": "8618141"
},
{
"approved": "2014-11-04",
"country": "United States",
"expires": "2027-12-24",
"number": "8877933"
},
{
"approved": "2012-02-28",
"country": "United States",
"expires": "2020-01-12",
"number": "8124630"
},
{
"approved": "2014-09-23",
"country": "United States",
"expires": "2020-01-12",
"number": "8841330"
},
{
"approved": "2007-06-26",
"country": "United States",
"expires": "2020-01-12",
"number": "7235576"
},
{
"approved": "2011-03-01",
"country": "United States",
"expires": "2020-01-12",
"number": "7897623"
},
{
"approved": "2008-04-01",
"country": "United States",
"expires": "2020-01-12",
"number": "7351834"
},
{
"approved": "2017-08-22",
"country": "United States",
"expires": "2028-09-10",
"number": "9737488"
}
] |
4-(4-((((4-Chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-N-methyl-2-pyridinecarboxamide | N-(4-Chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcarbamoyl)-4-pyridyloxy)phenyl)urea | Sorafénib | Sorafenib | Sorafenibum | 2.7.11.1 | BRAF1 | p94 | Proto-oncogene B-Raf | RAFB1 | v-Raf murine sarcoma viral oncogene homolog B1 | 2.7.10.1 | ERBB | ERBB1 | HER1 | Proto-oncogene c-ErbB-1 | Receptor tyrosine-protein kinase erbB-1 | 2.7.11.1 | cRaf | Proto-oncogene c-RAF | RAF | Raf-1 | 2.7.10.1 | FLT-4 | Fms-like tyrosine kinase 4 | Tyrosine-protein kinase receptor FLT4 | VEGFR-3 | VEGFR3 | 2.7.10.1 | Fetal liver kinase 1 | FLK-1 | FLK1 | KDR | Kinase insert domain receptor | Protein-tyrosine kinase receptor flk-1 | VEGFR-2 | VEGFR2 | 2.7.10.1 | FLT | FLT-1 | Fms-like tyrosine kinase 1 | FRT | Tyrosine-protein kinase FRT | Tyrosine-protein kinase receptor FLT | Vascular permeability factor receptor | VEGFR-1 | VEGFR1 | 2.7.10.1 | CD135 | Fetal liver kinase-2 | FL cytokine receptor | FLK-2 | FLK2 | FLT-3 | Fms-like tyrosine kinase 3 | Stem cell tyrosine kinase 1 | STK-1 | STK1 | 2.7.10.1 | Beta platelet-derived growth factor receptor | Beta-type platelet-derived growth factor receptor | CD140 antigen-like family member B | PDGF-R-beta | PDGFR | PDGFR-1 | PDGFR-beta | PDGFR1 | Platelet-derived growth factor receptor 1 | 2.7.10.1 | p145 c-kit | PBT | Piebald trait protein | Proto-oncogene c-Kit | SCFR | Tyrosine-protein kinase Kit | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog | 2.7.10.1 | Basic fibroblast growth factor receptor 1 | bFGF-R-1 | BFGFR | CEK | FGFBR | FGFR-1 | FLG | FLT-2 | FLT2 | Fms-like tyrosine kinase 2 | HBGFR | N-sam | Proto-oncogene c-Fgr | 2.7.10.1 | Cadherin family member 12 | CDHF12 | CDHR16 | Proto-oncogene c-Ret | PTC | 1,4-cineole 2-exo-monooxygenase | 1,8-cineole 2-exo-monooxygenase | 1.14.14.1 | Albendazole monooxygenase (sulfoxide-forming) | Albendazole sulfoxidase | Cholesterol 25-hydroxylase | CYP3A3 | CYPIIIA3 | CYPIIIA4 | Cytochrome P450 3A3 | Cytochrome P450 HLp | Cytochrome P450 NF-25 | Cytochrome P450-PCN1 | Nifedipine oxidase | Quinine 3-monooxygenase | (R)-limonene 6-monooxygenase | (S)-limonene 6-monooxygenase | (S)-limonene 7-monooxygenase | 1.14.14.1 | Cholesterol 25-hydroxylase | CYP2C10 | CYPIIC9 | Cytochrome P-450MP | Cytochrome P450 MP-4 | Cytochrome P450 MP-8 | Cytochrome P450 PB-1 | S-mephenytoin 4-hydroxylase | 1.14.14.1 | CYPIIC8 | Cytochrome P450 form 1 | Cytochrome P450 IIC2 | Cytochrome P450 MP-12 | Cytochrome P450 MP-20 | S-mephenytoin 4-hydroxylase | 1.14.14.1 | CYPIIIA5 | Cytochrome P450-PCN3 | 1.14.14.1 | CYPIIIA7 | Cytochrome P450-HFLA | P450HLp2 | 1,4-cineole 2-exo-monooxygenase | 1.14.13.- | CYPIIB6 | Cytochrome P450 IIB1 | 1.14.14.1 | Cholesterol 25-hydroxylase | CYPIA2 | Cytochrome P(3)450 | Cytochrome P450 4 | Cytochrome P450-P3 | Hydroperoxy icosatetraenoate dehydratase | (R)-limonene 6-monooxygenase | (S)-limonene 6-monooxygenase | (S)-limonene 7-monooxygenase | 1.14.14.1 | CYPIIC17 | CYPIIC19 | Cytochrome P450-11A | Cytochrome P450-254C | Fenbendazole monooxygenase (4'-hydroxylating) | Mephenytoin 4-hydroxylase | 1.14.14.- | Cholesterol 25-hydroxylase | CYP2DL1 | CYPIID6 | Cytochrome P450-DB1 | Debrisoquine 4-hydroxylase | 2.4.1.17 | GNT1 | lugP4 | UDP-glucuronosyltransferase 1-9 | UDP-glucuronosyltransferase 1-I | UDPGT 1-9 | UGT-1I | UGT1 | UGT1-09 | UGT1.9 | UGT1*9 | UGT1A9 | UGT1I | 2.4.1.17 | Bilirubin-specific UDPGT isozyme 1 | GNT1 | hUG-BR1 | UDP-glucuronosyltransferase 1-1 | UDP-glucuronosyltransferase 1A isoform 1 | UDPGT 1-1 | UGT1 | UGT1-01 | UGT1.1 | UGT1*1 | UGT1A1 | ATP-binding cassette sub-family B member 1 | MDR1 | Multidrug resistance protein 1 | P-glycoprotein 1 | PGY1 | Phospholipid transporter ABCB1 | 7.6.2.2 | ABCP | ATP-binding cassette sub-family G member 2 | BCRP | BCRP1 | Breast cancer resistance protein | CDw338 | Mitoxantrone resistance-associated protein | MXR | Placenta-specific ATP-binding cassette transporter | Urate exporter | 7.6.2.- | 7.6.2.2 | 7.6.2.3 | MOAT-B | MOATB | MRP/cMOAT-related ABC transporter | MRP4 | Multi-specific organic anion transporter B | Multidrug resistance-associated protein 4 | 7.6.2.- | 7.6.2.2 | 7.6.2.3 | Canalicular multidrug resistance protein | Canalicular multispecific organic anion transporter 1 | CMOAT | CMOAT1 | CMRP | MRP2 | Multidrug resistance-associated protein 2 | 76 kDa Ral-interacting protein | Dinitrophenyl S-glutathione ATPase | DNP-SG ATPase | Ral-interacting protein 1 | RalBP1 | RLIP | RLIP1 | RLIP76 | Liver-specific organic anion transporter 1 | LST-1 | LST1 | OATP-2 | OATP-C | OATP1B1 | OATP2 | OATPC | Organic anion transporter SLC21A6 | SLC21A6 | SLCO1B1 | Sodium-independent organic anion-transporting polypeptide 2 | Solute carrier family 21 member 6
|
[
"Apo-sorafenib",
"Nexavar",
"Nexavar",
"Nexavar",
"Nexavar",
"Nexavar",
"Sorafenib",
"Sorafenib",
"Sorafenib",
"Sorafenib",
"Sorafenib",
"Sorafenib",
"Sorafenib",
"Sorafenib Accord",
"Sorafenib Tosylate"
] |
[] |
[] |
[
"P15056",
"P00533",
"P04049",
"P35916",
"P35968",
"P17948",
"P36888",
"P09619",
"P10721",
"P11362",
"P07949"
] |
[
"P08684",
"P11712",
"P10632",
"P20815",
"P24462",
"P20813",
"P05177",
"P33261",
"P10635",
"O60656",
"P22309"
] |
[] |
[
"P08183",
"Q9UNQ0",
"O15439",
"Q92887",
"Q15311",
"Q9Y6L6"
] |
DB00400
|
Griseofulvin
|
An antifungal antibiotic. Griseofulvin may be given by mouth in the treatment of tinea infections.
|
solid
|
For the treatment of ringworm infections of the skin, hair, and nails, namely: tinea corporis, tinea pedis, tinea cruris, tinea barbae, cradle cap or other conditions caused by <i>Trichophyton</i> or <i>Microsporum</i> fungi.
|
Griseofulvin is a mycotoxic metabolic product of <i>Penicillium spp.</i> It was the first available oral agent for the treatment of dermatophytoses and has now been used for more than forty years. Griseofulvin is fungistatic with in vitro activity against various species of Microsporum Epidermophyton, and Trichophyton. It has no effect on bacteria or on other genera of fungi. Following oral administration, griseofulvin is deposited in the keratin precursor cells and has a greater affinity for diseased tissue. The drug is tightly bound to the new keratin which becomes highly resistant to fungal invasions. Once the keratin-Griseofulvin complex reaches the skin site of action, it binds to fungal microtubules (tubulin) thus altering fungal mitosis.
|
Griseofulvin is fungistatic, however the exact mechanism by which it inhibits the growth of dermatophytes is not clear. It is thought to inhibit fungal cell mitosis and nuclear acid synthesis. It also binds to and interferes with the function of spindle and cytoplasmic microtubules by binding to alpha and beta tubulin. It binds to keratin in human cells, then once it reaches the fungal site of action, it binds to fungal microtubes thus altering the fungal process of mitosis.
|
Poorly absorbed from GI ranging from 25 to 70% of an oral dose. Absorption is significantly enhanced by administration with or after a fatty meal.
|
Primarily hepatic with major metabolites being 6-methyl-griseofulvin and its glucuronide conjugate.
|
Side effects are minor: headaches, gastrointestinal reactions and cutaneous eruptions.
|
9-21 hours
| null | null | null | null |
Organic compounds
|
Organoheterocyclic compounds
|
Benzofurans
| null |
[
"approved",
"investigational",
"vet_approved"
] |
[
"D01BA",
"D01B",
"D01",
"D",
"D01AA",
"D01A",
"D01",
"D"
] |
[
"Yeast and other Trichophyton or Microsporum fungi",
"Dermatophytic fungi including Trichophyton, Microsporum and Epidermophyton"
] |
[
{
"cost": "2.2",
"description": "Griseofulvin powder",
"unit": "g"
},
{
"cost": "2.24",
"description": "Gris-peg 125 mg tablet",
"unit": "tablet"
},
{
"cost": "2.75",
"description": "Gris-peg 250 mg tablet",
"unit": "tablet"
},
{
"cost": "4.78",
"description": "Grifulvin v 500 mg tablet",
"unit": "tablet"
},
{
"cost": "43.0",
"description": "Griseofulvin Microsize 125 mg/5ml Suspension 120ml Bottle",
"unit": "bottle"
}
] |
[] |
(+)-griseofulvin | Amudane | Griseofulvin | Griseofulvin, microcrystalline | Griseofulvin, ultramicrosize | Griseofulvina | Griséofulvine | Griseofulvinum | Beta-tubulin | CK-12 | Cytokeratin-12 | K12 | Keratin-12 | 1.14.14.1 | Cholesterol 25-hydroxylase | CYPIA2 | Cytochrome P(3)450 | Cytochrome P450 4 | Cytochrome P450-P3 | Hydroperoxy icosatetraenoate dehydratase | 1,4-cineole 2-exo-monooxygenase | 1,8-cineole 2-exo-monooxygenase | 1.14.14.1 | Albendazole monooxygenase (sulfoxide-forming) | Albendazole sulfoxidase | Cholesterol 25-hydroxylase | CYP3A3 | CYPIIIA3 | CYPIIIA4 | Cytochrome P450 3A3 | Cytochrome P450 HLp | Cytochrome P450 NF-25 | Cytochrome P450-PCN1 | Nifedipine oxidase | Quinine 3-monooxygenase
|
[
"Fulvicin Pg Tab 330mg",
"Fulvicin U/f Tab 250mg",
"Fulvicin Uf Tab 500mg",
"Grifulvin V",
"Grifulvin V",
"Gris-PEG",
"Gris-PEG",
"Gris-PEG",
"Gris-PEG",
"Gris-PEG",
"Griseofulviin (microsize)",
"Griseofulvin",
"Griseofulvin",
"Griseofulvin",
"Griseofulvin",
"Griseofulvin",
"Griseofulvin",
"Griseofulvin",
"Griseofulvin",
"Griseofulvin",
"Griseofulvin",
"Griseofulvin",
"Griseofulvin",
"Griseofulvin",
"Griseofulvin",
"Griseofulvin",
"Griseofulvin",
"Griseofulvin",
"Griseofulvin",
"Griseofulvin",
"Griseofulvin MICROSIZE",
"Griseofulvin Microsize",
"Griseofulvin Oral Suspension",
"Grisofulvin",
"Grisovin Fp Tab 125mg",
"Grisovin Fp Tab 250mg",
"Grisovin Fp Tab 500mg",
"Grisovin-FP 125mg Tab",
"Grisovin-FP 250mg Tab",
"Ultramicrosize Griseofulvin",
"Ultramicrosize Griseofulvin",
"Ultramicrosize Griseofulvin",
"Ultramicrosize Griseofulvin",
"Ultramicrosize Griseofulvin",
"Ultramicrosize Griseofulvin",
"Ultramicrosize Griseofulvin",
"Ultramicrosize Griseofulvin",
"Ultramicrosize Griseofulvin",
"Ultramicrosize Griseofulvin",
"Ultramicrosize Griseofulvin",
"Ultramicrosize Griseofulvin",
"Ultramicrosize Griseofulvin",
"Ultramicrosize Griseofulvin"
] |
[
"Crivicin",
"Curling factor",
"Fulcin",
"Fulvicin",
"Grifulvin",
"Grisactin",
"Grison-250",
"Grisovin",
"Lamoryl",
"Likuden",
"Poncyl",
"S-Fulvin",
"Spirofulvin",
"Sporostatin"
] |
[] |
[
"Q99456"
] |
[
"P05177",
"P08684"
] |
[] |
[] |
DB00401
|
Nisoldipine
|
Nisoldipine is a 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, nisoldipine prevents calcium-dependent smooth muscle contraction and subsequent vasoconstriction. Nisoldipine may be used in alone or in combination with other agents in the management of hypertension.
|
solid
|
For the treatment of hypertension. It may be used alone or in combination with other antihypertensive agents.
|
Nisoldipine, a dihydropyridine calcium-channel blocker, is used alone or with an angiotensin-converting enzyme inhibitor, to treat hypertension, chronic stable angina pectoris, and Prinzmetal's variant angina. Nisoldipine is similar to other peripheral vasodilators. Nisoldipine inhibits the influx of extra cellular calcium across the myocardial and vascular smooth muscle cell membranes possibly by deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum. The decrease in intracellular calcium inhibits the contractile processes of the myocardial smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload.
|
By deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum, Nisoldipine inhibits the influx of extracellular calcium across the myocardial and vascular smooth muscle cell membranes The decrease in intracellular calcium inhibits the contractile processes of the myocardial smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload.
|
Relatively well absorbed into the systemic circulation with 87% of the radiolabeled drug recovered in urine and feces. The absolute bioavailability of nisoldipine is about 5%.
|
Pre-systemic metabolism in the gut wall, and this metabolism decreases from the proximal to the distal parts of the intestine. Nisoldipine is highly metabolized; 5 major urinary metabolites have been identified. The major biotransformation pathway appears to be the hydroxylation of the isobutyl ester. A hydroxylated derivative of the side chain, present in plasma at concentrations approximately equal to the parent compound, appears to be the only active metabolite and has about 10% of the activity of the parent compound. Cytochrome P450 enzymes are believed to play a major role in the metabolism of nisoldipine. The particular isoenzyme system responsible for its metabolism has not been identified, but other dihydropyridines are metabolized by cytochrome P450 IIIA4.
| null |
7-12 hours
|
99%
|
Although 60-80% of an oral dose undergoes urinary excretion, only traces of unchanged nisoldipine are found in urine.
| null | null |
Organic compounds
|
Organoheterocyclic compounds
|
Pyridines and derivatives
|
Hydropyridines
|
[
"approved"
] |
[
"C08CA",
"C08C",
"C08",
"C"
] |
[
"Humans and other mammals"
] |
[
{
"cost": "2.36",
"description": "Sular 10 mg 24 Hour tablet",
"unit": "tablet"
},
{
"cost": "2.61",
"description": "Sular 40 mg tablet",
"unit": "tablet"
},
{
"cost": "3.1",
"description": "Sular 30 mg tablet",
"unit": "tablet"
},
{
"cost": "3.23",
"description": "Sular 30 mg 24 Hour tablet",
"unit": "tablet"
},
{
"cost": "3.23",
"description": "Sular 40 mg 24 Hour tablet",
"unit": "tablet"
},
{
"cost": "3.37",
"description": "Sular 20 mg tablet",
"unit": "tablet"
},
{
"cost": "4.13",
"description": "Sular 8.5 mg tablet",
"unit": "tablet"
},
{
"cost": "4.35",
"description": "Sular 25.5 mg tablet",
"unit": "tablet"
},
{
"cost": "4.65",
"description": "Nisoldipine er 20 mg tablet",
"unit": "tablet"
},
{
"cost": "5.04",
"description": "Sular 10 mg tablet",
"unit": "tablet"
},
{
"cost": "5.04",
"description": "Sular 8.5 mg 24 Hour tablet",
"unit": "tablet"
},
{
"cost": "5.07",
"description": "Nisoldipine er 30 mg tablet",
"unit": "tablet"
},
{
"cost": "5.07",
"description": "Nisoldipine er 40 mg tablet",
"unit": "tablet"
},
{
"cost": "5.17",
"description": "Sular 17 mg tablet",
"unit": "tablet"
},
{
"cost": "5.64",
"description": "Sular 34 mg tablet",
"unit": "tablet"
},
{
"cost": "6.48",
"description": "Sular 17 mg 24 Hour tablet",
"unit": "tablet"
},
{
"cost": "6.84",
"description": "Sular 25.5 mg 24 Hour tablet",
"unit": "tablet"
},
{
"cost": "6.84",
"description": "Sular 34 mg 24 Hour tablet",
"unit": "tablet"
}
] |
[
{
"approved": "1997-05-06",
"country": "United States",
"expires": "2014-11-30",
"number": "5626874"
},
{
"approved": "1995-06-06",
"country": "United States",
"expires": "2012-06-06",
"number": "5422123"
}
] |
isobutyl methyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate | Nisoldipin | Nisoldipina | Nisoldipine | Nisoldipino | Nisoldipinum | CACH2 | CACN2 | CACNL1A1 | Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle | CCHL1A1 | Voltage-gated calcium channel subunit alpha Cav1.2 | CACNL2A | CCHL2A | MHS3 | Voltage-gated calcium channel subunit alpha-2/delta-1 | CAB2 | CACNLB2 | Calcium channel voltage-dependent subunit beta 2 | Lambert-Eaton myasthenic syndrome antigen B | MYSB | CACH3 | CACN4 | CACNL1A2 | Calcium channel, L type, alpha-1 polypeptide, isoform 2 | CCHL1A2 | Voltage-gated calcium channel subunit alpha Cav1.3 | CACH1 | CACN1 | CACNL1A3 | Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle | Voltage-gated calcium channel subunit alpha Cav1.1 | 1,4-cineole 2-exo-monooxygenase | 1,8-cineole 2-exo-monooxygenase | 1.14.14.1 | Albendazole monooxygenase (sulfoxide-forming) | Albendazole sulfoxidase | Cholesterol 25-hydroxylase | CYP3A3 | CYPIIIA3 | CYPIIIA4 | Cytochrome P450 3A3 | Cytochrome P450 HLp | Cytochrome P450 NF-25 | Cytochrome P450-PCN1 | Nifedipine oxidase | Quinine 3-monooxygenase | 1.14.14.1 | CYPIIIA5 | Cytochrome P450-PCN3 | 1.14.14.1 | CYPIIIA7 | Cytochrome P450-HFLA | P450HLp2 | ATP-binding cassette sub-family B member 1 | MDR1 | Multidrug resistance protein 1 | P-glycoprotein 1 | PGY1 | Phospholipid transporter ABCB1
|
[
"Nisoldipine",
"Nisoldipine",
"Nisoldipine",
"Nisoldipine",
"Nisoldipine",
"Nisoldipine",
"Nisoldipine",
"Nisoldipine",
"Nisoldipine",
"Nisoldipine",
"Nisoldipine",
"Nisoldipine",
"Nisoldipine",
"Nisoldipine",
"Nisoldipine",
"Nisoldipine",
"Nisoldipine",
"Sular",
"Sular",
"Sular",
"Sular",
"Sular",
"Sular",
"Sular",
"Sular"
] |
[
"Baymycard",
"Baymycard RR",
"Bo Ping",
"Di Yi Xin",
"Ji Ni Le Er",
"Ninobarucin",
"Nisomynard",
"Riohard",
"Ruidi",
"Syscor"
] |
[] |
[
"Q13936",
"P54289",
"Q08289",
"Q01668",
"Q13698"
] |
[
"P08684",
"P20815",
"P24462"
] |
[] |
[
"P08183"
] |
DB00402
|
Eszopiclone
|
Eszopiclone, marketed by Sepracor under the brand-name Lunesta, is a nonbenzodiazepine hypnotic drug used to treat insomnia. It is the active stereoisomer of zopiclone, belonging to the class of drugs known as _cyclopyrrolones_.[A179638,L6850] Cyclopyrrolone drugs demonstrate high efficacy and low toxicity[A179827], offering a safer alternative to other drugs used for insomnia.
One major benefit of eszopiclone is that it is approved by the FDA for the long-term treatment of insomnia. This sets it apart from many other hypnotic sedatives, which are generally approved only for the relief of short-term (6-8 weeks) insomnia. Eszopiclone was initially approved by the FDA in 2004.[L6769]
|
solid
|
Eszopiclone is indicated for the treatment of insomnia.[L6769]
|
Eszopiclone rapidly induces sleep and decreases sleep latency. It also aids in the maintenance of sleep, preventing frequent awakenings.[A179659,A179662,L6769] This drug has shown anticonvulsant and muscle relaxant properties in animals but is used in humans for its sedating effects.[A179827]
Eszopiclone is a central nervous system depressant with various effects. These include changes in alertness and motor coordination and the risk of next morning impairment, increasing with the amount of eszopiclone administered. Exercise caution and advise against driving a motor vehicle or activities that require full mental alertness the next morning.[L6769] Complex sleep behaviors may result from eszopiclone use. Eszopiclone should be discontinued in these cases.[L6874] Avoid the use of alcohol and other CNS depressants when eszopiclone is administered. Advise patients to skip the eszopiclone dose if alcohol has been consumed before bed or during the evening. Use the smallest dose of eszopiclone as possible, especially in elderly patients, who may experience exaggerated drug effects. Though the potential for dependence and abuse with eszopiclone is lower than for other hypnotic drugs, this drug has been abused and is known to cause dependence.[L6868]
|
The exact mechanism of action of eszopiclone is unknown at this time but is thought to occur via binding with the GABA receptor complexes at binding sites located near benzodiazepine receptors, possibly explaining its hypnotic and sedative effects.[A179659,L6769] It has particular affinity for GABA-A (or GABAA) receptor subunits 1, 3 and 5.[A179788,A15625,A15626] Eszopiclone increases GABA-A channel currents significantly.[A179788] GABA-A channels are major inhibitory channels that cause CNS depression when their receptors are activated.[A179800]
|
Eszopiclone is rapidly absorbed and the peak concentration is reached within about 1 hour after oral administration.[A179659,L6769] The mean AUC after a 3 mg dose of eszopiclone was 278 ng/mL × h.[A179638] The consumption of a high-fat has been shown to slow absorption. Steady-state concentrations of eszopiclone are reached within 24-48 hours.[A179662]
|
Following oral administration, eszopiclone is extensively biotransformed and the major metabolites are S-desmethylzopiclone and zopiclone-N-oxide, which are largely inactive.[A179641]. The enzymes involved in the metabolism of eszopiclone are CYP3A (the primary metabolizing enzyme), CYP2C8, and CYP2E1.[A179641]
The N-oxide derivative shows weak pharmacological activity in animals. The N-desmethyl metabolite is pharmacologically active.[L6769]
|
The oral LD50 of eszopiclone in rats is 980 mg/kg and 3200 mg/kg in rabbits.[L6853] Symptoms of overdose may include mental status changes and somnolence, demonstrating general exaggeration of the drug's pharmacological effects. Perform gastric lavage and offer supportive treatment if an overdose is suspected, including intravenous fluids as required. Flumazenil may be used. Vital signs should be closely monitored in addition to patient symptoms. Appropriate medical interventions should be employed. The possibility of an overdose with multiple drugs should be considered. Ensure to contact the local poison control center for the most updated management of hypnotic drug overdose.[L6769]
|
The half-life is 6.1 hours in healthy patients but is prolonged in various patients, including those with hepatic impairment, elderly patients, in addition to those taking CYP3A enzyme inhibiting drugs.[A179638,L6769]
|
This drug is 52-59% bound to plasma proteins.[L6769]
|
Only about 10% of an eszopiclone dose is found excreted in the urine as the parent drug.[A179659,L6769] As much as 75% of an orally administered dose of racemic zopiclone as is found to be excreted in the urine in the form of metabolites. Eszopiclone, the S-isomer of racemic zopiclone, would likely show the same excretion pattern.[L6769]
|
The volume of distribution of eszopiclone is estimated at 89.9L[L6802]
|
The mean clearance of eszopiclone in young, healthy volunteers was 184 mL/min in one pharmacokinetic study.[A179638]
|
Organic compounds
|
Organoheterocyclic compounds
|
Pyrrolopyrazines
|
Cyclopyrrolones
|
[
"approved",
"investigational"
] |
[
"N05CF",
"N05C",
"N05",
"N"
] |
[
"Humans and other mammals"
] |
[
{
"cost": "7.24",
"description": "Lunesta 1 mg tablet",
"unit": "tablet"
},
{
"cost": "7.28",
"description": "Lunesta 3 mg tablet",
"unit": "tablet"
},
{
"cost": "8.08",
"description": "Lunesta 2 mg tablet",
"unit": "tablet"
}
] |
[
{
"approved": "2002-09-03",
"country": "United States",
"expires": "2014-02-14",
"number": "6444673"
},
{
"approved": "2001-11-20",
"country": "United States",
"expires": "2012-01-16",
"number": "6319926"
}
] |
(+)-(5S)-6-(5-Chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo(3,4-b)pyrazin-5-yl 4-methylpiperazine-1-carboxylate | (+)-(5S)-6-(5-chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl-4-methylpiperazine-1-carboxylate | (+)-Zopiclone | (S)-6-(5-Chloro-2-pyridinyl)- 7-oxo- 6,7-dihydro- 5H-pyrrolo[3,4-b]pyrazin-5-yl- 4-methyl- 1-piperazinecarboxylate | (S)-Zopiclone | 1-Piperazinecarobxylic acid,4-methyl-,(5S)-6-(5-chloro-2-pyridinyl)-6,7-dihydro-7-oxo-5H-pyrrolo[3,4-b]pyrazin-5-yl ester | Esopiclone | Eszopiclone | GABA(A) receptor subunit alpha-1 | GABAAR subunit alpha-1 | BZRP | MBR | Mitochondrial benzodiazepine receptor | PBR | Peripheral-type benzodiazepine receptor | PKBS | GABA(A) receptor subunit alpha-1 | GABAAR subunit alpha-1 | GABA(A) receptor subunit alpha-2 | GABAAR subunit alpha-2 | GABA(A) receptor subunit alpha-3 | GABAAR subunit alpha-3 | GABA(A) receptor subunit alpha-4 | GABAAR subunit alpha-4 | GABA(A) receptor subunit alpha-5 | GABAAR subunit alpha-5 | GABA(A) receptor subunit alpha-6 | GABAAR subunit alpha-6 | GABA(A) receptor subunit beta-1 | GABAAR subunit beta-1 | GABA(A) receptor subunit beta-2 | GABAAR subunit beta-2 | GABA(A) receptor subunit beta-3 | GABAAR subunit beta-3 | GABA(A) receptor subunit delta | GABAAR subunit delta | GABA(A) receptor subunit epsilon | GABAAR subunit epsilon | GABA(A) receptor subunit gamma-1 | GABAAR subunit gamma-1 | GABA(A) receptor subunit gamma-2 | GABAAR subunit gamma-2 | GABA(A) receptor subunit gamma-3 | GABAAR subunit gamma-3 | GABA(A) receptor subunit pi | GABAAR subunit pi | GABA(A) receptor subunit theta | GABAAR subunit theta | GABA(A) receptor subunit alpha-2 | GABAAR subunit alpha-2 | GABA(A) receptor subunit alpha-3 | GABAAR subunit alpha-3 | GABA(A) receptor subunit alpha-5 | GABAAR subunit alpha-5 | 1,4-cineole 2-exo-monooxygenase | 1,8-cineole 2-exo-monooxygenase | 1.14.14.1 | Albendazole monooxygenase (sulfoxide-forming) | Albendazole sulfoxidase | Cholesterol 25-hydroxylase | CYP3A3 | CYPIIIA3 | CYPIIIA4 | Cytochrome P450 3A3 | Cytochrome P450 HLp | Cytochrome P450 NF-25 | Cytochrome P450-PCN1 | Nifedipine oxidase | Quinine 3-monooxygenase | 1.14.14.1 | CYPIIC8 | Cytochrome P450 form 1 | Cytochrome P450 IIC2 | Cytochrome P450 MP-12 | Cytochrome P450 MP-20 | S-mephenytoin 4-hydroxylase
|
[
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Eszopiclone",
"Lunesta",
"Lunesta",
"Lunesta",
"Lunesta",
"Lunesta",
"Lunesta",
"Lunesta",
"Lunesta",
"Lunesta",
"Lunesta",
"Lunesta",
"Lunesta",
"Lunesta",
"Lunesta",
"Lunesta",
"Lunesta",
"Lunesta",
"Lunesta",
"Lunesta",
"Lunesta",
"Lunesta",
"Lunesta",
"Lunesta",
"Lunesta",
"Lunesta",
"Lunesta",
"Lunesta",
"Lunesta",
"Lunesta",
"Lunesta",
"Lunesta",
"Lunesta",
"Lunesta",
"M-eszopiclone",
"M-eszopiclone",
"M-eszopiclone",
"Mar-eszopiclone",
"Mar-eszopiclone",
"Mar-eszopiclone"
] |
[
"Dorplen",
"Esleep",
"Eszop",
"Fulnite",
"Inductal",
"Isoklon",
"Nirvan",
"Noptic",
"Plessir",
"Sanilent",
"Sleepil",
"Sono",
"Valnoc",
"Wen Fei",
"Zopilone",
"Zopinon"
] |
[] |
[
"P14867",
"P30536",
"P14867",
"P47869",
"P34903",
"P48169",
"P31644",
"Q16445",
"P18505",
"P47870",
"P28472",
"O14764",
"P78334",
"Q8N1C3",
"P18507",
"Q99928",
"O00591",
"Q9UN88",
"P47869",
"P34903",
"P31644"
] |
[
"P08684",
"P10632"
] |
[] |
[] |
DB00403
|
Ceruletide
|
Caerulein is a specific decapeptide similar in action and composition to the natural gastrointestinal peptide hormone cholecystokinin. It exerts stimulatory effects on the gastric, biliary, and pancreatic secretion, as well as on certain smooth muscles.
|
solid
|
Caerulein is used in the treatment of paralytic ileus and as diagnostic aid in pancreatic malfunction.
|
Caerulein is a specific decapeptide similar in action and composition to the natural gastrointestinal peptide hormone cholecystokinin that stimulates gastric, biliary, and pancreatic secretion. It also exerts stimulatory actions on certain smooth muscles.
|
Caerulein acts according to its similarity to the natural gastrointestinal peptide hormone cholecystokinin. Cholecystokinin is a peptide hormone of the gastrointestinal system responsible for stimulating the digestion of fat and protein. Cholecystokinin is secreted by the duodenum, the first segment of the small intestine. There it binds to CCK receptors, activating them and causing downstream effects. Specifically, it results in the release of digestive enzymes and bile from the pancreas and gall bladder, respectively. It also acts as a hunger suppresant. Cholecystokinin is secreted by the duodenum when fat- or protein-rich chyme leaves the stomach and enters the duodenum. The hormone acts on the pancreas to stimulate the secretion of the enzymes lipase, amylase, trypsin, and chymotrypsin. Together these pancreatic enzymes catalyze the digestion of fat and protein. Cholecystokinin also stimulates both the contraction of the gall bladder, and the relaxtion of the Sphincter of Oddi (Glisson's Sphinctor), which delivers, (not secretes) bile into the small intestine. Bile salts serve to emulsify fats, thereby increasing the effectiveness with which enzymes can digest them.
|
Absorbed following intravenous administration.
| null | null | null | null | null | null | null |
Organic compounds
|
Organic Polymers
|
Polypeptides
| null |
[
"approved"
] |
[
"V04CC",
"V04C",
"V04",
"V"
] |
[
"Humans and other mammals"
] |
[] |
[] |
Caerulein | Cerulein | Ceruletida | Ceruletide | Ceruletidum | CCK-A receptor | CCK-AR | CCK1-R | CCKRA | Cholecystokinin-1 receptor | CCK-B receptor | CCK-BR | CCK2-R | CCKRB | Cholecystokinin-2 receptor
|
[] |
[
"Takus"
] |
[] |
[
"P32238",
"P32239"
] |
[] |
[] |
[] |
DB00404
|
Alprazolam
|
Alprazolam is a triazolobenzodiazepine indicated for the treatment of anxiety and panic disorders.[L34783, L34788] It is mainly metabolized by CYP3As and so is contraindicated with CYP3A inhibitors like ketoconazole and itraconazole.[L34783, L34788] Benzodiazepine treatment should be stopped gradually by tapering down a patient's dose to avoid withdrawal symptoms.[A18125] Alprazolam's adverse effects are generally related to the sedation it can cause.[A18125] Alprazolam has been mixed with alcohol as a drug of abuse to potentiate the sedative effects of the drug which may lead to coma and death.[A18125] Alprazolam was given FDA approval on October 16, 1981.[L6148]
|
solid
|
Alprazolam is indicated for the acute treatment of generalized anxiety disorder in adults.[L34783] Alprazolam is also indicated, either as a standard or extended-release formulation, for the treatment of panic disorder with or without agoraphobia in adults.[L34783, L34788]
Alprazolam may also be prescribed off-label for insomnia, premenstrual syndrome, and depression.[A177973]
|
Alprazolam is a benzodiazepine that binds γ-aminobutyric acid (GABA) type-A receptors (GABA<sub>A</sub>Rs) to enhance their inhibitory effect on neurotransmission, specifically in the brain.[L34783, L34788] Concomitant use with opioids may result in profound sedation, respiratory depression, coma, and death; patients taking benzodiazepines and opioids concurrently may require lower doses of one or both medications, depending on their clinical situation. Patients with pre-existing impaired respiratory function are at increased risk of adverse effects including death during treatment with benzodiazepines. In addition, due to its CNS depressant effects, patients taking alprazolam should avoid operating heavy machinery or driving and should avoid other CNS depressants such as alcohol. As with other benzodiazepines, alprazolam carries a risk of abuse, misuse, and addiction, which is higher in predisposed individuals and may require strict monitoring. Cessation of therapy may result in acute or protracted withdrawal symptoms, which may be life-threatening; the patient dose should be gradually tapered whenever discontinuation or reduced dosage are necessary. Newborns born to mothers using alprazolam later in pregnancy may suffer from sedation and withdrawal symptoms. As CYP3A is required for the initial step in alprazolam metabolism, alprazolam is contraindicated in patients taking strong CYP3A inhibitors, such as ketoconazole and itraconazole; milder CYP3A inhibitors still necessitate alprazolam dosage adjustments. Lastly, benzodiazepines may have negative effects, such as panic disorders, increased suicide incidence, and episodes of mania/hypomania, in patients suffering from depression.[A18125, A236788, L34783, L34788]
|
Neurotransmission relies on excitatory and inhibitory signalling. γ-aminobutyric acid (GABA) type-A receptors (GABA<sub>A</sub>Rs) are members of the pentameric ligand-gated ion channel (PLGIC) superfamily located synaptically and perisynaptically to mediate phasic inhibition and extrasynaptically to mediate tonic inhibition. GABA<sub>A</sub>Rs comprise a variety of subunits from a homologous family whose members are named based on sequence identity as one of α1-6, β1-3, γ1-3, δ, ε, θ, π, and ρ1-3. Each subunit possesses an extracellular (ECD), transmembrane (TMD), and intracellular (ICD) domain; inter-subunit interfaces are the primary points of neurotransmitter and modulator binding, described by coordination of the principal (+) and complementary (-) sites in each subunit. Binding of GABA to GABA<sub>A</sub>Rs induces pore opening, rapid flow of chloride ions, and synaptic hyperpolarization, which in turn manifests as an inhibitory signal.[A236793, A236798]
The most prevalent GABA<sub>A</sub>Rs _in vivo_ are the α1β2γ2 receptors, which contain both GABA (β+/α-) and benzodiazepine (BZD, α+/γ-) binding sites in the intersubunit interfaces of the relevant subunits.[A236793, A236798, A236828] In general, any receptors containing an α<sub>x</sub>/γ<sub>z</sub> interface, where x = 1-3,5 and z = 1-3, have potential high-affinity BZD binding sites, although small sequence differences between subunits may alter binding affinity to individual molecules. The α4 and α6 subunits, in which an otherwise conserved histidine is replaced by arginine, do not bind traditional BZD ligands such as diazepam and hence are considered "diazepam-insensitive".[A236793, A236798, A236828] GABA binding results in a series of conformational changes in the ECDs of GABA<sub>A</sub>R β subunits, "locking" each to its neighbouring α- interface. The binding of alprazolam in the high-affinity BZD site stabilizes the α+/γ- interface and facilitates the conformational changes that lead to pore opening, hence functioning as a positive allosteric modulator.[A236833]
The exact manner in which GABA<sub>A</sub>R allosteric modulation mediates the therapeutic and unwanted effects of benzodiazepines remains unclear.[A177973, A18125] Earlier studies suggested that the primary factor was the α subunit composition, with α1-containing receptors mediating the sedative effects, α2/3-containing receptors the anxiolytic effects, and α5-containing receptors the memory effects of benzodiazepines.[A236838] More recent studies suggest a more complex set of factors including subunit composition, physiological location, neuronal circuit, and nerve cell type.[A236843] To further complicate matters, there may be up to five distinct BZD binding sites on GABA<sub>A</sub>Rs, with site 1 corresponding to the classical high-affinity α+/γ- interface. The effects of binding at sites 2-4 are not fully understood and likely impart greater complexity to benzodiazepine pharmacological action.[A236798, A236828]
|
Alprazolam administered orally is rapidly absorbed in the gastrointestinal tract, reaching C<sub>max</sub> in about 1.8 (1-2) hours. Absorption is high, resulting in an oral bioavailability of 84-91%. A 1 mg oral dose results in a C<sub>max</sub> of 12-22 μg/L.[A177925, L34783]
The extended-release formulation of alprazolam (XANAX XR) has similar absorption, bioavailability, and pharmacokinetics as the standard release, with the exception that the T<sub>max</sub> is ~10 hours compared to 1-2 hours. Temporal dosing alters these parameters, with C<sub>max</sub> increasing by 30% and T<sub>max</sub> decreasing by one hour when dosed at night as opposed to in the morning.[L34788]
Food has an effect on alprazolam absorption; a high-fat meal up to two hours before dosing increases the C<sub>max</sub> by ~25% and either a reduction (food consumed immediately prior to dosing) or increase (food consumed after dosing) of ~1/3 in T<sub>max</sub>. Neither the AUC nor half-life are appreciably affected by eating.[L34788]
|
Alprazolam is metabolized to less effective metabolites by various CYPs including CYP3A4, CYP3A5, CYP3A7, and CYP2C9.[A415, A14775, L162, L34783, L34788] The majority of alprazolam metabolism is mediated by hydroxylation via CYP3As.[A415, A14775, A177925, L162, L34783, L34788] 4-hydroxyalprazolam has 20% the binding affinity of the parent drug, alpha-hydroxyalprazolam has 66% the affinity, and the benzophenone metabolite has <1% the affinity.[A177925, L34783, L34788]
|
Alprazolam overdose can present as sleepiness, confusion, poor coordination, slow reflexes, coma, and death.[L34783, L34788] Taking alprazolam with alcohol lowers the threshold for overdose.[L34783, L34788] Patients should have their respiration, pulse, and blood pressure monitored.[L34783, L34788] Patients can be treated by gastric lavage and intravenous fluids.[L34783, L34788]. If hypotension occurs, patients may be treated with vasopressors.[L34783, L34788] In known, or suspected overdoses, patients can be given the benzodiazepine receptor antagonist [flumazenil] in addition to other methods of management.[L34783, L34788]
Oral LD50 in rats is 331-2171mg/kg.[Label]
|
Alprazolam has a mean plasma elimination half-life of 11.2 hours in healthy patients (range 6.3-26.9 hours).[L34783] The mean half-life is 16.3 hours (range 9.0-26.9 hours) in the elderly, 21.8 hours (range 9.9-40.4 hours) in obese patients, and 19.7 hours (range 5.8-65.3 hours) in patients with alcoholic liver disease.[L34783] The half-life is 25% higher in Asian patients compared to Caucasians.[L34783] Other studies have shown the half-life to be 9-16h.[A177925] The extended-release formulation has a half-life of 10.7-15.8 hours in healthy adult patients.[L34788]
|
Alprazolam is ~80% protein-bound in serum.[L34783, L34788] The majority of this protein binding is to serum albumin.[A177922, L34783, L34788] Alprazolam is also bound to alpha1-acid glycoprotein with low frequency.[A177925]
|
Alprazolam is mainly eliminated in the urine.[L34783, L34788] A large portion of the dose is eliminated as unmetabolized alprazolam.[A177925] <10% of the dose is eliminated as alpha-hydroxy-alprazolam and 4-hydroxy-alprazolam.[A177925]
|
Alprazolam has a volume of distribution following oral administration of 0.8-1.3L/kg.[A177925] Alprazolam crosses the blood-brain barrier.[A18125]
|
A 0.8 mg oral dose of alprazolam had a clearance of 0.90 ± 0.21 mL/min/kg, which increased to 2.13 ± 0.54 mL/min/kg when coadministered with the strong CYP3A4 inducer carbamazepine.[L34783, L34788] Other studies have demonstrated a clearance of 0.70-1.5mL/min/kg.[A177925]
|
Organic compounds
|
Organoheterocyclic compounds
|
Benzodiazepines
|
1,4-benzodiazepines
|
[
"approved",
"illicit",
"investigational"
] |
[
"N05BA",
"N05B",
"N05",
"N"
] |
[
"Humans and other mammals"
] |
[
{
"cost": "1.07",
"description": "ALPRAZolam 0.5 mg 24 Hour tablet",
"unit": "tablet"
},
{
"cost": "1.09",
"description": "Xanax 0.25 mg tablet",
"unit": "tablet"
},
{
"cost": "1.22",
"description": "Alprazolam 2 mg tablet",
"unit": "tablet"
},
{
"cost": "1.3",
"description": "Xanax 0.5 mg tablet",
"unit": "tablet"
},
{
"cost": "2.23",
"description": "Alprazolam 1 mg/ml oral conc",
"unit": "ml"
},
{
"cost": "2.29",
"description": "Xanax 1 mg tablet",
"unit": "tablet"
},
{
"cost": "2.33",
"description": "ALPRAZolam 1 mg 24 Hour tablet",
"unit": "tablet"
},
{
"cost": "2.43",
"description": "Niravam 0.25 mg tablet",
"unit": "tablet"
},
{
"cost": "2.53",
"description": "ALPRAZolam 2 mg 24 Hour tablet",
"unit": "tablet"
},
{
"cost": "2.93",
"description": "Xanax xr 0.5 mg tablet",
"unit": "tablet"
},
{
"cost": "3.01",
"description": "Xanax XR 0.5 mg 24 Hour tablet",
"unit": "tablet"
},
{
"cost": "3.02",
"description": "Niravam 0.5 mg tablet",
"unit": "tablet"
},
{
"cost": "3.45",
"description": "Niravam 0.25 mg Dispersible Tablet",
"unit": "dispersible tablet"
},
{
"cost": "3.64",
"description": "Xanax XR 1 mg 24 Hour tablet",
"unit": "tablet"
},
{
"cost": "3.64",
"description": "Xanax xr 1 mg tablet",
"unit": "tablet"
},
{
"cost": "3.67",
"description": "ALPRAZolam 3 mg 24 Hour tablet",
"unit": "tablet"
},
{
"cost": "3.82",
"description": "Xanax 2 mg tablet",
"unit": "tablet"
},
{
"cost": "4.04",
"description": "Niravam 1 mg tablet",
"unit": "tablet"
},
{
"cost": "4.2",
"description": "Niravam 0.5 mg Dispersible Tablet",
"unit": "dispersible tablet"
},
{
"cost": "4.73",
"description": "Xanax XR 2 mg 24 Hour tablet",
"unit": "tablet"
},
{
"cost": "4.84",
"description": "Xanax xr 2 mg tablet",
"unit": "tablet"
},
{
"cost": "5.42",
"description": "Niravam 1 mg Dispersible Tablet",
"unit": "dispersible tablet"
},
{
"cost": "6.86",
"description": "Niravam 2 mg tablet",
"unit": "tablet"
},
{
"cost": "7.1",
"description": "Xanax XR 3 mg 24 Hour tablet",
"unit": "tablet"
},
{
"cost": "7.25",
"description": "Xanax xr 3 mg tablet",
"unit": "tablet"
},
{
"cost": "8.53",
"description": "Niravam 2 mg Dispersible Tablet",
"unit": "dispersible tablet"
},
{
"cost": "67.03",
"description": "ALPRAZolam Intensol 1 mg/ml Concentrate 30ml Bottle",
"unit": "bottle"
},
{
"cost": "0.08",
"description": "Apo-Alpraz 0.25 mg Tablet",
"unit": "tablet"
},
{
"cost": "0.08",
"description": "Mylan-Alprazolam 0.25 mg Tablet",
"unit": "tablet"
},
{
"cost": "0.08",
"description": "Novo-Alprazol 0.25 mg Tablet",
"unit": "tablet"
},
{
"cost": "0.1",
"description": "Apo-Alpraz 0.5 mg Tablet",
"unit": "tablet"
},
{
"cost": "0.1",
"description": "Mylan-Alprazolam 0.5 mg Tablet",
"unit": "tablet"
},
{
"cost": "0.1",
"description": "Novo-Alprazol 0.5 mg Tablet",
"unit": "tablet"
},
{
"cost": "0.55",
"description": "Alprazolam 0.25 mg tablet",
"unit": "tablet"
},
{
"cost": "0.67",
"description": "Alprazolam 0.5 mg tablet",
"unit": "tablet"
},
{
"cost": "0.78",
"description": "Alprazolam 1 mg tablet",
"unit": "tablet"
}
] |
[
{
"approved": "2001-04-24",
"country": "United States",
"expires": "2018-04-09",
"number": "6221392"
},
{
"approved": "2000-02-15",
"country": "United States",
"expires": "2018-04-09",
"number": "6024981"
}
] |
8-Chloro-1-methyl-6-phenyl-4H-s-triazolo(4,3-a)(1,4)benzodiazepine | Alprazolam | GABA(A) receptor subunit alpha-1 | GABAAR subunit alpha-1 | GABA(A) receptor subunit alpha-2 | GABAAR subunit alpha-2 | GABA(A) receptor subunit alpha-3 | GABAAR subunit alpha-3 | GABA(A) receptor subunit alpha-4 | GABAAR subunit alpha-4 | GABA(A) receptor subunit alpha-5 | GABAAR subunit alpha-5 | GABA(A) receptor subunit alpha-6 | GABAAR subunit alpha-6 | GABA(A) receptor subunit beta-1 | GABAAR subunit beta-1 | GABA(A) receptor subunit beta-2 | GABAAR subunit beta-2 | GABA(A) receptor subunit beta-3 | GABAAR subunit beta-3 | GABA(A) receptor subunit delta | GABAAR subunit delta | GABA(A) receptor subunit epsilon | GABAAR subunit epsilon | GABA(A) receptor subunit gamma-1 | GABAAR subunit gamma-1 | GABA(A) receptor subunit gamma-2 | GABAAR subunit gamma-2 | GABA(A) receptor subunit gamma-3 | GABAAR subunit gamma-3 | GABA(A) receptor subunit pi | GABAAR subunit pi | GABA(A) receptor subunit theta | GABAAR subunit theta | BZRP | MBR | Mitochondrial benzodiazepine receptor | PBR | Peripheral-type benzodiazepine receptor | PKBS | GABA(A) receptor subunit alpha-1 | GABAAR subunit alpha-1 | GABA(A) receptor subunit alpha-2 | GABAAR subunit alpha-2 | GABA(A) receptor subunit alpha-3 | GABAAR subunit alpha-3 | GABA(A) receptor subunit alpha-5 | GABAAR subunit alpha-5 | GABA(A) receptor subunit gamma-1 | GABAAR subunit gamma-1 | GABA(A) receptor subunit gamma-2 | GABAAR subunit gamma-2 | GABA(A) receptor subunit gamma-3 | GABAAR subunit gamma-3 | 1.14.14.1 | CYPIIIA7 | Cytochrome P450-HFLA | P450HLp2 | 1,4-cineole 2-exo-monooxygenase | 1,8-cineole 2-exo-monooxygenase | 1.14.14.1 | Albendazole monooxygenase (sulfoxide-forming) | Albendazole sulfoxidase | Cholesterol 25-hydroxylase | CYP3A3 | CYPIIIA3 | CYPIIIA4 | Cytochrome P450 3A3 | Cytochrome P450 HLp | Cytochrome P450 NF-25 | Cytochrome P450-PCN1 | Nifedipine oxidase | Quinine 3-monooxygenase | (R)-limonene 6-monooxygenase | (S)-limonene 6-monooxygenase | (S)-limonene 7-monooxygenase | 1.14.14.1 | Cholesterol 25-hydroxylase | CYP2C10 | CYPIIC9 | Cytochrome P-450MP | Cytochrome P450 MP-4 | Cytochrome P450 MP-8 | Cytochrome P450 PB-1 | S-mephenytoin 4-hydroxylase | 1.14.14.1 | CYPIIIA5 | Cytochrome P450-PCN3 | AGP 1 | AGP1 | OMD 1 | Orosomucoid-1 | AGP 2 | AGP2 | OMD 2 | Orosomucoid-2
|
[
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam",
"Alprazolam C-IV",
"Alprazolam C-IV",
"Alprazolam ER",
"Alprazolam ER",
"Alprazolam Extended Release",
"ALPRAZOLAM extended release",
"ALPRAZOLAM extended release",
"ALPRAZOLAM extended release",
"ALPRAZOLAM extended release",
"Alprazolam Extended Release",
"Alprazolam Extended Release",
"Alprazolam Extended Release",
"Alprazolam Extended Release",
"Alprazolam Extended Release",
"Alprazolam Extended Release",
"Alprazolam Extended Release",
"Alprazolam Extended Release",
"Alprazolam Extended-release",
"Alprazolam Extended-Release",
"Alprazolam Extended-Release",
"Alprazolam Extended-Release",
"Alprazolam Extended-Release",
"Alprazolam Extended-release",
"Alprazolam Extended-release",
"Alprazolam Extended-release",
"Alprazolam Extended-release",
"Alprazolam Extended-release",
"Alprazolam Extended-release",
"Alprazolam Extended-release",
"Alprazolam Extended-release",
"Alprazolam Extended-release",
"Alprazolam Tablets 0.25",
"Alprazolam Tablets 0.5mg",
"Alprazolam XR",
"Alprazolam XR",
"Alprazolam XR",
"Alprazolam XR",
"Alprazolam XR",
"Alprazolam XR",
"Alprazolam XR",
"Alprazolam XR",
"Apo-alpraz",
"Apo-alpraz",
"Apo-alpraz",
"Apo-alpraz Ts",
"Gabazolamine",
"Gabazolamine-0.5",
"Jamp Alprazolam",
"Jamp Alprazolam",
"Jamp Alprazolam",
"Jamp Alprazolam",
"Jamp-alprazolam",
"Jamp-alprazolam",
"Jamp-alprazolam",
"Jamp-alprazolam",
"Mylan-alprazolam",
"Mylan-alprazolam",
"Mylan-alprazolam",
"Mylan-alprazolam",
"Nat-alprazolam",
"Nat-alprazolam",
"Nat-alprazolam",
"Nat-alprazolam",
"Niravam",
"Niravam",
"Niravam",
"Niravam",
"Niravam",
"Niravam",
"Niravam",
"Niravam",
"Niravam",
"Ntp-alprazolam",
"Ntp-alprazolam",
"Nu-alpraz Tab 0.25mg",
"Nu-alpraz Tab 0.5mg",
"Pro-alprazolam",
"Pro-alprazolam",
"Pro-alprazolam",
"Pro-alprazolam Ts",
"Ratio-alprazolam",
"Ratio-alprazolam",
"Riva-alprazolam",
"Riva-alprazolam",
"Riva-alprazolam",
"Riva-alprazolam",
"Riva-alprazolam 0.25 mg",
"Riva-alprazolam 0.5 mg",
"Sentrazolam AM",
"Teva-alprazolam",
"Teva-alprazolam",
"Xanax",
"Xanax",
"Xanax",
"Xanax",
"Xanax",
"Xanax",
"Xanax",
"Xanax",
"Xanax",
"Xanax",
"Xanax Ts",
"Xanax XR",
"Xanax XR",
"Xanax XR",
"Xanax XR",
"Xanax XR",
"Xanax XR",
"Xanax XR",
"Xanax XR"
] |
[
"Alplax",
"Alprazolan",
"Alpronax",
"Alprox",
"Alviz",
"Cassadan",
"Esparon",
"Ralozam",
"Restyl",
"Solanax",
"Staccato alprazolam",
"Tafil",
"Trankimazin",
"Tranquinal",
"Xanor"
] |
[
"Sentrazolam AM",
"Gabazolamine-0.5",
"Gabazolamine"
] |
[
"P14867",
"P47869",
"P34903",
"P48169",
"P31644",
"Q16445",
"P18505",
"P47870",
"P28472",
"O14764",
"P78334",
"Q8N1C3",
"P18507",
"Q99928",
"O00591",
"Q9UN88",
"P30536",
"P14867",
"P47869",
"P34903",
"P31644",
"Q8N1C3",
"P18507",
"Q99928"
] |
[
"P24462",
"P08684",
"P11712",
"P20815"
] |
[
"P02768",
"P02763",
"P19652"
] |
[] |
DB00405
|
Dexbrompheniramine
|
Dexbrompheniramine maleate is an antihistamine agent that is used for the treatment of allergic conditions, such as hay fever or urticaria.
|
solid
|
For treatment and relief of symptoms of allergies, hay fever, and colds
|
In allergic reactions an allergen interacts with and cross-links surface IgE antibodies on mast cells and basophils. Once the mast cell-antibody-antigen complex is formed, a complex series of events occurs that eventually leads to cell-degranulation and the release of histamine (and other chemical mediators) from the mast cell or basophil. Once released, histamine can react with local or widespread tissues through histamine receptors. Histamine, acting on H<sub>1</sub>-receptors, produces pruritis, vasodilatation, hypotension, flushing, headache, tachycardia, and bronchoconstriction. Histamine also increases vascular permeability and potentiates pain. Dexbrompheniramine is a histamine H1 antagonist (or more correctly, an inverse histamine agonist) of the alkylamine class. It provides effective, temporary relief of sneezing, watery and itchy eyes, and runny nose due to hay fever and other upper respiratory allergies.
|
Dexbrompheniramine competitively binds to the histamine H<sub>1</sub>-receptor. It competes with histamine for the normal H<sub>1</sub>-receptor sites on effector cells of the gastrointestinal tract, blood vessels and respiratory tract. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine.
|
Antihistamines are well absorbed from the gastrointestinal tract after oral administration.
|
Hepatic (cytochrome P-450 system), some renal.
|
Signs of an overdose include fast or irregular heartbeat, mental or mood changes, tightness in the chest, and unusual tiredness or weakness.
|
25 hours
| null | null | null | null |
Organic compounds
|
Organoheterocyclic compounds
|
Pyridines and derivatives
|
Pheniramines
|
[
"approved"
] |
[
"R06AB",
"R06A",
"R06",
"R",
"R06AB",
"R06A",
"R06",
"R"
] |
[
"Humans and other mammals"
] |
[
{
"cost": "0.82",
"description": "Ala-hist ir 2 mg tablet",
"unit": "tablet"
}
] |
[] |
(+)-brompheniraminum | (R)-3-(4-Bromophenyl)-3-(2-pyridyl)propyldimethylamine | (S)-(+)-brompheniramine | (S)-brompheniramine | 3-(4-bromophenyl)- N,N-dimethyl- 3-pyridin-2-yl-propan-1-amine | d-brompheniramine | Desbrofeniramina | Dexbromfeniramina | Dexbrompheniramin | Dexbromphéniramine | Dexbrompheniramine | Dexbrompheniraminum | H1-R | H1R | HH1R
|
[
"Accu Tuss DM",
"Acticon",
"Acticon",
"Acticon",
"Actidogesic",
"Actidogesic DF",
"Ala-hist Ir",
"Ala-hist PE",
"Alahist CF",
"Alahist DM",
"Alahist PE",
"Bio-cnex",
"Biogesic",
"Bionatuss DXP",
"BranTussin DM",
"Brompheniramine Maleate Pseudoephedrine HCl",
"Chlo Hist",
"Chlo Hist",
"Chlo Tuss",
"Chlo Tuss",
"Conex",
"Conex",
"Coricidin 'd' Nasal and Sinus Congestion",
"Coricidin D Nasal and Sinus Congestion Tablets",
"Dallergy",
"Dallergy",
"Dexbrompheniramine Maleate and Phenylephrine Hydrochloride",
"Dexbrompheniramine-DM-Phenylephrine 2-15-7.5",
"Dexbrompherniramine Maleate and Pseudoephedrine Sulfate 6mg/120mg",
"Dologen",
"Dologen 325",
"Dologesic DF",
"Dologesic NF",
"Drixoral Cold & Sinus",
"Drixoral Day/night - Srt/tabs",
"Drixoral Syrup",
"Drixtab Tab",
"G-Con-X",
"G-Dologen",
"G-P-tuss Dxp",
"M-end Dmx",
"M-end Max D",
"Panatuss DXP",
"Panatuss Pediatric Drops DXP",
"PediaVent",
"PediaVent",
"Polytussin DM",
"Supress A",
"WesTussin DM NF"
] |
[
"Disophrol",
"Drixoral"
] |
[
"Brompheniramine Maleate Pseudoephedrine HCl",
"Panatuss Pediatric Drops DXP",
"Panatuss DXP",
"Chlo Tuss",
"G-Con-X",
"Dologesic NF",
"Dologesic DF",
"M-end Max D",
"Biogesic",
"Bio-cnex",
"Supress A",
"Dallergy",
"Dallergy",
"Bionatuss DXP",
"Actidogesic",
"Acticon",
"Acticon",
"Dexbrompherniramine Maleate and Pseudoephedrine Sulfate 6mg/120mg",
"Conex",
"Conex",
"G-Dologen",
"Dologen 325",
"Dologen",
"Chlo Hist",
"Alahist DM",
"Ala-hist PE",
"Alahist CF",
"Dexbrompheniramine Maleate and Phenylephrine Hydrochloride",
"Chlo Tuss",
"Chlo Hist",
"M-end Dmx",
"G-P-tuss Dxp",
"Actidogesic DF",
"Alahist PE",
"Polytussin DM",
"Drixoral Syrup",
"Drixoral Day/night - Srt/tabs",
"Drixtab Tab",
"Coricidin 'd' Nasal and Sinus Congestion",
"Coricidin D Nasal and Sinus Congestion Tablets",
"Drixoral Cold & Sinus",
"Acticon",
"BranTussin DM",
"Dexbrompheniramine-DM-Phenylephrine 2-15-7.5",
"WesTussin DM NF",
"Accu Tuss DM"
] |
[
"P35367"
] |
[] |
[] |
[] |
DB00406
|
Gentian violet cation
|
A dye that is a mixture of violet rosanilinis with antibacterial, antifungal, and anthelmintic properties.
|
solid
|
For the treatment of bacterial and fungal infections inside the mouth (thrush) and skin, also for the prevention of transmission of Chagas' disease (as a blood additive).
|
Gentian violet is a mutagen, a mitotic poison, and a clastogen. Gentian violet has been used in medicine for almost 100 years: as an antiseptic for external use, as a topical antibiotic, as a topical antifungal agent, as an antihelminthic agent by oral administration, and more recently, as a blood additive to prevent transmission of Chagas' disease. It is thought to work by binding to the DNA of target organisms and causing disruption, mutation or inhibition of DNA replication.
|
In aqueous solutions Gentian violet (GV) dissociates into positive (GV+)and negative ions (Cl-) that penetrate through the wall and membrane of both gram-positive and gram-negative bacterial cells. The GV+ interacts with negatively charged components of bacterial cells including the lipopolysaccharide (on the cell wall), the peptidoglycan and DNA. A similar cell penetration and DNA binding process is thought to take place for fungal cells as well. Because Gentian violet is a mutagen and mitotic poison, cell growth is consequently inhibited. A photodynamic action of gentian violet, apparently mediated by a free-radical mechanism, has recently been described in bacteria and in the protozoan T. cruzi. Evidence also suggests that gentian violet dissipates the bacterial (and mitochondrial) membrane potential by inducing permeability. This is followed by respiratory inhibition. This anti-mitochondrial activity might explain gentian violet's efficacy towards both bacteria and yeast with relatively mild effects on mammalian cells.
| null |
Primarily hepatic, mostly demethylation
|
LD<sub>50</sub>=420 mg/kg (rat, oral). Oral administration can cause gastrointestinal irritation, and intravenous injection can cause depression in the white blood cell count.
| null | null | null | null | null |
Organic compounds
|
Benzenoids
|
Benzene and substituted derivatives
|
Diphenylmethanes
|
[
"approved"
] |
[
"G01AX",
"G01A",
"G01",
"G",
"D01AE",
"D01A",
"D01",
"D"
] |
[
"Yeast and other fungi",
"Bacteria and protozoa"
] |
[
{
"cost": "0.08",
"description": "Gentian violet 1% solution",
"unit": "ml"
},
{
"cost": "0.16",
"description": "Gentian violet 2% solution",
"unit": "ml"
}
] |
[] |
Crystal Violet | Crystal violet carbocation | Crystal violet ion(1) | Crystal violet(1+) | Gentian violet carbocation | Gentian violet cation | Gentian violet(1+) | Methylrosaniline | Methylrosanilinium | hOCT1 | OCT1 | Organic cation transporter 1
|
[
"De LA Cruz Gentian Violet",
"El Valle Gentian Violet",
"Gentian Violet",
"Gentian Violet 1%",
"Gentian Violet 1%",
"Gentian Violet 2%",
"Gentian Violet Anti-Infective",
"Gentian Violet Topical Solution",
"Gentiane Violet Liq Top",
"GNP Gentian Violet 1%",
"Humco Gentian Violet 1%",
"Humco Gentian Violet 2%",
"Kerr 100 Triple Dye Dispos-A",
"Perineze Triple Dye",
"Triple Dye"
] |
[] |
[
"Perineze Triple Dye",
"Kerr 100 Triple Dye Dispos-A",
"Triple Dye"
] |
[] |
[] |
[] |
[
"O15245"
] |
DB00407
|
Ardeparin
|
Ardeparin, marketed under the US trade name Normiflo, is a low molecular weight heparin (LMWH) anticoagulant used for the prevention of postoperative venous thrombosis. Ardeparin is derived via peroxide degradation of heparin extracted from porcine intestinal mucosa. Its molecular weight ranges from 2000 to 15,000 with an average molecular weight of 5500 to 6500. Normiflo was withdrawn from the US market in March 2000.
|
solid
|
For prevention of deep vein thrombosis, which may result in pulmonary embolism, following knee surgery.
|
Ardeparin, an anticoagulant, is a fractionated heparin. It acts at multiple sites in the normal coagulation system to inhibit reactions that lead to the clotting of blood and the formation of fibrin clots both <i>in vitro</i> and <i>in vivo</i>.
|
Ardeparin binds to antithrombin III, accelerating its activity in inactivating factor Xa and thrombin, thereby inhibiting thrombosis. Ardeparin also binds to heparin cofactor II, inhibiting thrombin. Ardeparin does not effect prothrombin time (PT) assays and may prolong activated partial thromboplastin time (APTT). Ardeparin has double the anti-factor Xa activity versus anti-factor IIa activity, compared to unfractionated heparin which has approximately equal anti-factor Xa activity and anti-factor IIa activity.
|
Well absorbed following subcutaneous administration, with a mean bioavailability of 92% (based on anti-factor Xa activity).
|
Liver and the reticulo-endothelial system are the sites of biotransformation.
|
Symptoms of overdose may include excessive bleeding and bruising.
|
Elimination half-life for anti-factor Xa activity averages 3.3 hours following a single intravenous dose, while elimination half-life for anti-factor IIa activity averages 1.2 hours following a single intravenous dose.
| null | null | null | null | null | null | null | null |
[
"approved",
"investigational",
"withdrawn"
] |
[] |
[
"Humans and other mammals"
] |
[] |
[] |
AT3 | ATIII | Serpin C1 | HC-II | HCF2 | Heparin cofactor II | HLS2 | Protease inhibitor leuserpin-2 | Serpin D1
|
[] |
[
"Normiflo"
] |
[] |
[
"P01008",
"P05546"
] |
[] |
[] |
[] |
DB00408
|
Loxapine
|
An antipsychotic agent used in schizophrenia. [PubChem]
|
solid
|
For the management of the manifestations of psychotic disorders such as schizophrenia
|
Loxapine, a dibenzoxazepine compound, represents a subclass of tricyclic antipsychotic agents, chemically distinct from the thioxanthenes, butyrophenones, and phenothiazines. Pharmacologically, Loxapine is a tranquilizer for which the exact mode of action has not been established, however, it is believed that by antagonising dopamine and serotonin receptors, there is a marked cortical inhibition which can manifest as tranquilization and suppression of aggression.
|
Loxapine is a dopamine antagonist, and also a serotonin 5-HT2 blocker. The exact mode of action of Loxapine has not been established, however changes in the level of excitability of subcortical inhibitory areas have been observed in several animal species in association with such manifestations of tranquilization as calming effects and suppression of aggressive behavior.
|
Systemic bioavailability of the parent drug was only about one third that after an equivalent intramuscular dose (25 mg base) in male volunteers
|
Hepatic
|
LD<sub>50</sub>=65 mg/kg (Orally in mice)
|
Oral-4 hours
| null |
Metabolites are excreted in the urine in the form of conjugates and in the feces unconjugated.
| null | null |
Organic compounds
|
Organoheterocyclic compounds
|
Benzoxazepines
|
Dibenzoxazepines
|
[
"approved"
] |
[
"N05AH",
"N05A",
"N05",
"N"
] |
[
"Humans and other mammals"
] |
[
{
"cost": "1.03",
"description": "Loxapine Succinate 5 mg capsule",
"unit": "capsule"
},
{
"cost": "1.27",
"description": "Loxapine 10 mg capsule",
"unit": "capsule"
},
{
"cost": "1.58",
"description": "Loxitane 5 mg capsule",
"unit": "capsule"
},
{
"cost": "1.92",
"description": "Loxapine 25 mg capsule",
"unit": "capsule"
},
{
"cost": "2.04",
"description": "Loxitane 10 mg capsule",
"unit": "capsule"
},
{
"cost": "2.57",
"description": "Loxapine 50 mg capsule",
"unit": "capsule"
},
{
"cost": "3.09",
"description": "Loxitane 25 mg capsule",
"unit": "capsule"
},
{
"cost": "4.04",
"description": "Loxitane 50 mg capsule",
"unit": "capsule"
},
{
"cost": "7.05",
"description": "Loxapac 50 mg/ml",
"unit": "ml"
},
{
"cost": "0.08",
"description": "Pms-Loxapine 2.5 mg Tablet",
"unit": "tablet"
},
{
"cost": "0.16",
"description": "Pms-Loxapine 5 mg Tablet",
"unit": "tablet"
},
{
"cost": "0.26",
"description": "Pms-Loxapine 10 mg Tablet",
"unit": "tablet"
},
{
"cost": "0.41",
"description": "Pms-Loxapine 25 mg Tablet",
"unit": "tablet"
},
{
"cost": "0.54",
"description": "Pms-Loxapine 50 mg Tablet",
"unit": "tablet"
},
{
"cost": "0.99",
"description": "Loxapine 5 mg capsule",
"unit": "capsule"
}
] |
[
{
"approved": "2006-07-18",
"country": "United States",
"expires": "2021-10-26",
"number": "7078020"
},
{
"approved": "2006-05-30",
"country": "United States",
"expires": "2021-10-26",
"number": "7052679"
},
{
"approved": "2009-05-26",
"country": "United States",
"expires": "2024-10-28",
"number": "7537009"
},
{
"approved": "2012-05-08",
"country": "United States",
"expires": "2021-10-26",
"number": "8173107"
},
{
"approved": "2011-12-13",
"country": "United States",
"expires": "2022-07-25",
"number": "8074644"
},
{
"approved": "2015-03-31",
"country": "United States",
"expires": "2024-05-21",
"number": "8991387"
},
{
"approved": "2015-02-17",
"country": "United States",
"expires": "2021-10-26",
"number": "8955512"
},
{
"approved": "2009-10-13",
"country": "United States",
"expires": "2021-10-26",
"number": "7601337"
},
{
"approved": "2012-08-07",
"country": "United States",
"expires": "2021-10-26",
"number": "8235037"
},
{
"approved": "2009-09-08",
"country": "United States",
"expires": "2021-10-26",
"number": "7585493"
},
{
"approved": "2008-12-02",
"country": "United States",
"expires": "2024-08-18",
"number": "7458374"
},
{
"approved": "2004-04-06",
"country": "United States",
"expires": "2022-05-20",
"number": "6716416"
},
{
"approved": "2013-03-05",
"country": "United States",
"expires": "2026-10-23",
"number": "8387612"
},
{
"approved": "2006-08-15",
"country": "United States",
"expires": "2021-10-26",
"number": "7090830"
},
{
"approved": "2016-06-21",
"country": "United States",
"expires": "2024-05-20",
"number": "9370629"
},
{
"approved": "2016-09-13",
"country": "United States",
"expires": "2021-10-26",
"number": "9440034"
},
{
"approved": "2016-09-13",
"country": "United States",
"expires": "2021-10-26",
"number": "9439907"
},
{
"approved": "2017-06-27",
"country": "United States",
"expires": "2021-10-26",
"number": "9687487"
}
] |
2-Chloro-11-(4-methyl-1-piperazinyl)dibenz[b,f][1,4]oxazepine | Loxapina | Loxapine | Loxapinum | Oxilapine | 5-HT-2 | 5-HT-2A | HTR2 | Serotonin receptor 2A | Dopamine D2 receptor | 5-HT-1C | 5-HT-2C | 5-HT1C | 5-HT2C | 5-HTR2C | 5-hydroxytryptamine receptor 1C | HTR1C | Serotonin receptor 2C | 5-HT-1A | 5-HT1A | ADRB2RL1 | ADRBRL1 | G-21 | Serotonin receptor 1A | 5-HT-1B | 5-HT-1D-beta | 5-HT1B | HTR1DB | S12 | Serotonin 1D beta receptor | Serotonin receptor 1B | 5-HT-1D | 5-HT-1D-alpha | 5-HT1D | HTR1DA | HTRL | Serotonin 1D alpha receptor | Serotonin receptor 1D | 5-HT-1E | 5-HT1E | S31 | Serotonin receptor 1E | 5-HT-3 | 5-HT3-A | 5-HT3A | 5-HT3R | 5-hydroxytryptamine receptor 3 | 5HT3R | HTR3 | Serotonin receptor 3A | Serotonin-gated ion channel receptor | 5-HT-5 | 5-HT-5A | 5-HT5A | Serotonin receptor 5A | 5-HT-6 | 5-HT6 | Serotonin receptor 6 | 5-HT-7 | 5-HT-X | 5-HT7 | Serotonin receptor 7 | ADRA1C | Alpha-1A adrenoceptor | Alpha-1A adrenoreceptor | Alpha-1C adrenergic receptor | Alpha-adrenergic receptor 1c | Alpha-1B adrenoceptor | Alpha-1B adrenoreceptor | ADRA2R | ADRAR | Alpha-2 adrenergic receptor subtype C10 | Alpha-2A adrenoceptor | Alpha-2A adrenoreceptor | Alpha-2AAR | ADRA2L1 | ADRA2RL1 | Alpha-2 adrenergic receptor subtype C2 | Alpha-2B adrenoceptor | Alpha-2B adrenoreceptor | Alpha-2BAR | ADRA2L2 | ADRA2RL2 | Alpha-2 adrenergic receptor subtype C4 | Alpha-2C adrenoceptor | Alpha-2C adrenoreceptor | Alpha-2CAR | ADRB1R | B1AR | Beta-1 adrenoceptor | Beta-1 adrenoreceptor | Dopamine D1 receptor | D(5) dopamine receptor | D1beta dopamine receptor | Dopamine D5 receptor | DRD1B | DRD1L2 | Dopamine D3 receptor | D(2C) dopamine receptor | Dopamine D4 receptor | D(5) dopamine receptor | D1beta dopamine receptor | Dopamine D5 receptor | DRD1B | DRD1L2 | H1-R | H1R | HH1R | Gastric receptor I | H2R | HH2R | AXOR35 | G-protein coupled receptor 105 | GPCR105 | GPRv53 | H4R | HH4R | Pfi-013 | SP9144 | 5HT transporter | 5HTT | HTT | SERT | Solute carrier family 6 member 4 | NAT1 | NET | NET1 | Norepinephrine transporter | SLC6A5 | Solute carrier family 6 member 2 | DA transporter | DAT | DAT1 | Solute carrier family 6 member 3 | Dopamine D1 receptor
|
[
"Adasuve",
"Adasuve",
"Adasuve",
"Adasuve",
"Adasuve",
"Adasuve",
"Adasuve",
"Apo-loxapine",
"Apo-loxapine",
"Apo-loxapine",
"Apo-loxapine",
"Dom-loxapine Tablets 10mg",
"Dom-loxapine Tablets 25mg",
"Dom-loxapine Tablets 50mg",
"Dom-loxapine Tablets 5mg",
"Loxapac - Tab 10mg",
"Loxapac - Tab 50mg",
"Loxapac - Tab 5mg",
"Loxapac Im",
"Loxapac Inj 50mg/ml",
"Loxapac Oral Concentrate-liq 25mg/ml",
"Loxapac Orl Conc 25mg/ml",
"Loxapac Tab 10mg",
"Loxapac Tab 25mg",
"Loxapac Tab 50mg",
"Loxapac Tab 5mg",
"Loxapac Tablets - 25 mg",
"Loxapine",
"Loxapine",
"Loxapine",
"Loxapine",
"Loxapine",
"Loxapine",
"Loxapine",
"Loxapine",
"Loxapine",
"Loxapine",
"Loxapine",
"Loxapine",
"Loxapine",
"Loxapine",
"Loxapine",
"Loxapine",
"Loxapine",
"Loxapine",
"Loxapine",
"Loxapine",
"Loxapine",
"Loxapine",
"Loxapine",
"Loxapine",
"Loxapine",
"Loxapine",
"Loxapine",
"Loxapine",
"Loxapine",
"Loxapine",
"Loxapine",
"Loxapine",
"Loxapine",
"Loxapine",
"Loxapine",
"Loxapine",
"Loxapine",
"Loxapine",
"Loxapine",
"Loxapine",
"Loxapine",
"Loxapine",
"Loxapine",
"Loxapine",
"Loxapine",
"Loxapine",
"Loxapine",
"Loxapine",
"Loxapine",
"Loxapine",
"Loxapine",
"Loxapine",
"Loxapine",
"Loxapine",
"Loxapine",
"Loxapine",
"Loxapine",
"Loxapine",
"Loxapine",
"Loxapine",
"Loxapine",
"Loxapine",
"Loxapine",
"Loxapine",
"Loxapine",
"Loxapine",
"Loxapine",
"Loxapine",
"Loxapine",
"Loxapine",
"Loxapine Hydrochloride Im Injection 50mg/ml",
"Loxapine Hydrochloride Oral Concentrate 25mg/ml",
"Loxapine Succinate",
"Loxapine Succinate",
"Loxapine Succinate",
"Loxapine Succinate",
"Loxapine Succinate",
"Loxapine Succinate",
"Loxapine Succinate Tablets 10mg",
"Loxapine Succinate Tablets 25mg",
"Loxapine Succinate Tablets 5 mg",
"Loxapine Succinate Tablets 50mg",
"Loxapine-10",
"Loxapine-25",
"Loxapine-5",
"Loxapine-50",
"Loxitane",
"Loxitane",
"Loxitane",
"Loxitane",
"PHL-loxapine",
"PHL-loxapine",
"PHL-loxapine",
"PHL-loxapine",
"PHL-loxapine",
"PHL-loxapine",
"PMS-loxapine",
"PMS-loxapine",
"PMS-loxapine",
"PMS-loxapine",
"PMS-loxapine",
"Xylac",
"Xylac",
"Xylac",
"Xylac",
"Xylac",
"Xylac"
] |
[
"Cloxazepine",
"Lopac",
"Losagen",
"Loxapac",
"Rosup"
] |
[] |
[
"P28223",
"P14416",
"P28335",
"P08908",
"P28222",
"P28221",
"P28566",
"P46098",
"P47898",
"P50406",
"P34969",
"P35348",
"P35368",
"P08913",
"P18089",
"P18825",
"P08588",
"P11229",
"P08172",
"P20309",
"P08173",
"P08912",
"P21728",
"P21918",
"P35462",
"P21917",
"P21918",
"P35367",
"P25021",
"Q9H3N8",
"P31645",
"P23975",
"Q01959",
"P21728"
] |
[] |
[] |
[] |
DB00409
|
Remoxipride
|
Remoxipride is an atypical antipsychotic agent that is specific for dopamine D<sub>2</sub> receptors.[A215422] It gained approval in the UK in 1989 but was withdrawn in 1993 after it was found to be associated with an increased incidence of aplastic anemia.[A215422,A215512]
|
solid
|
Remoxipride is an atypical antipsychotic once used for the treatment of schizophrenia.[A215532]
|
Remoxipride is a weak selective dopamine D<sub>2</sub> receptor antagonist that was once used in the treatment of schizophrenia.[A215422] It has a moderate therapeutic index and duration of action.[A215537] Remoxipride was withdrawn due to deaths associated with aplastic anemia.[A215512]
|
Remoxipride is an atypical antipsychotic dopamine D<sub>2</sub> antagonist.[A215422] Chronic use upregulates the expression of D<sub>2</sub> receptors, while downregulating the expression of D<sub>1</sub> and D<sub>5</sub> receptors in the prefrontal cortex.[A215422] This activity may be related to the antipsychotic activity of remoxipride.[A215422] Remoxipride displays weaker binding to D<sub>2</sub> dopaminergic receptors that dopamine.[A12818] This weaker binding is thought to account for the reduced incidence of Parkinsonism.[A12818] Remoxipride also increases expression of the protein _Fos_ in the nucleus accumbens but not the dorsolateral striatum, which may be responsible for a reduced incidence of extrapyramidal symptoms.[A215422]
|
Remoxipride is approximately 90% bioavailable.[A215502] In patients with normal creatinine clearance, remoxipride reaches a C<sub>max</sub> of 5.5 ± 1.1 µmol/L, with a T<sub>max</sub> of 0.8 ± 0.2 h, and an AUC of 39 ± 9 µmol\*h/L.[A215502] In patients with moderate renal impairment, remoxipride reaches a C<sub>max</sub> of 7.7 ± 2.7 µmol/L, with a T<sub>max</sub> of 0.9 ± 0.4 h, and an AUC of 63 ± 34 µmol\*h/L.[A215502] In patients with severe renal impairment, remoxipride reaches a C<sub>max</sub> of 9.3 ± 2.3 µmol/L, with a T<sub>max</sub> of 1.4 ± 0.9 h, and an AUC of 123 ± 60 µmol\*h/L.[A215502]
|
Remoxipride can be N-dealkylated to FLA 853, oxidized to FLA 850, or N-deethylated to FLA 838.[A215417,A215502] FLA 838 can be oxidized to NCL 118 which is further hydroxylated to NCM 009.[A215417,A215502] FLA 850 can be N-deethylated to NCL 118 or hydroxylated to NCM 001.[A215417,A215502] NCM 001 is further N-deethylated to NCM 009.[A215417,A215502] None of these metabolites have measurable activity on dopamine D<sub>2</sub> receptors.[A215502]
|
Remoxipride was withdrawn from the market after 8 cases of aplastic anemia were reported.[A215512] Of those 8 cases, 2 were fatal.[A215512]
|
The half life of remoxipride in patients with normal creatinine clearance is 5.1 ± 1.6 h, in patients with moderate renal impairment is 6.1 ± 2.6 h, and in patients with severe renal impairment is 9.9 ± 3.8 h.[A215502]
|
Remoxipride is approximately 80% protein bound, mainly to α-1-acid glycoprotein.[A215507]
|
A dose of remoxipride is 89% recovered in the urine and 7% in the feces.[A215507] 10-40% of a dose of remoxipride is recovered in the urine as the unchanged parent drug.[A215507]
|
The volume of distribution of remoxipride in patients with normal creatinine clearance is 44.3 ± 8.3 L, in patients with moderate renal impairment is 37.4 ± 16.2 L, and in patients with severe renal impairment is 30.2 ± 9.4 L.[A215502]
|
The renal clearance of remoxipride in patients with normal creatinine clearance is 23.6 ± 7.0 mL/min, in patients with moderate renal impairment is 9.3 ± 3.8 mL/min, and in patients with severe renal impairment is 3.7 ± 2.9 mL/min.[A215502] The systemic plasma clearance of remoxipride is 120 mL/min.[A215507]
|
Organic compounds
|
Benzenoids
|
Benzene and substituted derivatives
|
Methoxybenzenes
|
[
"approved",
"withdrawn"
] |
[
"N05AL",
"N05A",
"N05",
"N"
] |
[
"Humans and other mammals"
] |
[] |
[] |
Remoxiprida | Remoxipride | Remoxipridum | Dopamine D2 receptor | D(2C) dopamine receptor | Dopamine D4 receptor | Dopamine D3 receptor | 5-HT-2 | 5-HT-2A | HTR2 | Serotonin receptor 2A | Aging-associated gene 8 protein | hSigmaR1 | OPRS1 | SIG-1R | Sigma 1-type opioid receptor | Sigma1-receptor | Sigma1R | SR-BP | SR31747-binding protein | SRBP | 1.14.14.- | Cholesterol 25-hydroxylase | CYP2DL1 | CYPIID6 | Cytochrome P450-DB1 | Debrisoquine 4-hydroxylase | 1.14.14.1 | Cholesterol 25-hydroxylase | CYPIA2 | Cytochrome P(3)450 | Cytochrome P450 4 | Cytochrome P450-P3 | Hydroperoxy icosatetraenoate dehydratase | 1.14.14.1 | Cyp2b-1 | CYPIIB1 | Cytochrome P450-B | Cytochrome P450-LM2 | Cytochrome P450-PB1 | Cytochrome P450-PB2 | Cytochrome P450b | 1,4-cineole 2-exo-monooxygenase | 1,8-cineole 2-exo-monooxygenase | 1.14.14.1 | Albendazole monooxygenase (sulfoxide-forming) | Albendazole sulfoxidase | Cholesterol 25-hydroxylase | CYP3A3 | CYPIIIA3 | CYPIIIA4 | Cytochrome P450 3A3 | Cytochrome P450 HLp | Cytochrome P450 NF-25 | Cytochrome P450-PCN1 | Nifedipine oxidase | Quinine 3-monooxygenase | 1.14.14.1 | 1.14.14.1 | CYPIIIA5 | Cytochrome P450-PCN3 | 1.14.14.1 | CYPIIIA7 | Cytochrome P450-HFLA | P450HLp2 | AGP 1 | AGP1 | OMD 1 | Orosomucoid-1 | AGP 2 | AGP2 | OMD 2 | Orosomucoid-2
|
[] |
[
"Roxiam"
] |
[] |
[
"P14416",
"P21917",
"P35462",
"P28223",
"Q99720"
] |
[
"P10635",
"P05177",
"P08684",
"Q9HB55",
"P20815",
"P24462"
] |
[
"P02763",
"P19652"
] |
[] |
DB00410
|
Mupirocin
|
Mupirocin, formerly termed pseudomonic acid A,[A178531] is a novel antibacterial agent with a unique chemical structure and mode of action apart from other antibiotic agents. Produced by fermentation using the organism _Pseudomonas fluorescens_, mupirocin is a naturally-occurring antibiotic that displays a broad-specturm activity against many gram-positive bacteria and certain gram-negative bacteria _in vitro_.[L10580] It primarily works by inhibiting bacterial protein synthesis. Due to its unique mode of action of inhibiting the activity of bacterial isoleucyl-tRNA synthetase, mupirocin does not demonstrate cross-resistance with other classes of antimicrobial agents, giving it a therapeutic advantage.[L10580] It is available in topical formulations only due to extensive systemic metabolism[A178531] and is used in the treatment of impetigo caused by _Staphylococcus aureus_ and _Streptococcus pyogenes_ and traumatic skin lesions due to secondary skin infections caused by _S. aureus_ and _S. pyogenes_. There is also some clinical evidence that suggests the potential role of mupirocin in eradicating nasal carriage of Staphylococci when administered intranasally.[A178531,A178591] Mupirocin is commonly marketed under the brand name Bactroban.
|
solid
|
Indicated for the treatment of impetigo and secondary skin infections, leading to traumatic skin lesions, due to _Staphylococcus aureus_ and _Streptococcus pyogenes_.[L10580]
|
Mupirocin is reported to be active against susceptible aerobic gram-positive cocci, such as _Staphylococcus aureus_, _Staphylococcus epidermidis_, and other beta-hemolytic streptococci_Streptococcus pyogenes_.[A178594] It mediates its antibacterial activity by inhibiting the bacterial protein synthesis and formation of bacterial proteins essential for survival. The minimum bactericidal concentration (MBC) against relevant pathogens is generally eight-fold to thirty-fold higher than the minimum inhibitory concentration (MIC).[L10580] In one clinical study investigating the therapeutic effectiveness of topical mupirocin in impetigo, the therapeutic response rate was about 94 to 98% after one week following the end of therapy.[L10580] In clinical studies of patients with primary and secondary skin infections, both elimination of the bacterial pathogen and clinical cure or improvement hav been demonstrated in over 90% of patients receiving topical mupirocin.[A178591] Mupirocin resistance as high as 81% has been reported previously.[A178600] Resistance to mupirocin, which occurs more frequently in methicillin-resistant than methicillin-susceptible staphylococci, may occur with the production of a modified isoleucyl-tRNA synthetase, or the acquisition of, by genetic transfer, a plasmid mediating a new isoleucyl-tRNA synthetase.[L10580]
|
Mupirocin specifically and reversibly binds to bacterial isoleucyl transfer-RNA (tRNA) synthetase, which is an enzyme that promotes the conversion of isoleucine and tRNA to isoleucyl-tRNA. Inhibition of this enzyme subsequently leads to the inhibition of the bacterial protein and RNA synthesis.[A178531] Mupirocin is bacteriostatic at lower concentrations but it exerts bactericidal effects with prolonged exposure, killing 90-99% of susceptible bacteria over a 24 hour period.[A178552]
|
Systemic or percutaneous absorption of mupirocin following dermal application is expected to be minimal in adults and children.[L10580] Occlusive dressings do not significantly enhance drug absorption, but damaged skin may allow enhanced penetration of the drug across the skin barrier.[A178552]
|
Following intravenous or oral administration, mupirocin undergoes rapid hepatic metabolism to form the principal metabolite monic acid, which has no antibacterial activity.[L10580]
|
**LD<sub>50</sub> and Nonclinical Toxicity**
The oral LD<sub>50</sub> value in rats is 5000 mg/kg.[MSDS] Studies evaluating the carcinogenic potential of mupirocin have not been performed. In various _in vivo_ animal and _in vitro_ bacterial assays, there was no evidence of genotoxicity caused by mupirocin. In reproduction studies using male and female rats, there were no signs of impaired fertility upon subcutaneous administration of mupirocin.[L10580]
**Use in special populations**
Mupirocin was found to be excreted in human milk. As there is limited data on the use of topical mupirocin in pregnant women, the use of this drug in these patients should be undertaken with caution. Based on the findings in clinical trials, topical mupirocin was shown to be safe and effective in pediatric patients aged 2 months to 16 years.[L10580]
|
In healthy male volunteers, the elimination half-life of mupirocin was about 20 to 40 minutes following intravenous administration. The elimination half-life of monic acid was about 30 to 80 minutes.[L6349]
|
The protein binding of mupirocin is reported to be over 95%.[L10580]
|
Any mupirocin reaching the systemic circulation is rapidly metabolized to form the inactive monic acid, which is eliminated by renal excretion. Following the application of Centany (mupirocin ointment),2% to a 400 cm2 area on the back of 23 healthy volunteers once daily for 7 days, the mean (range) cumulative urinary excretion of monic acid over 24 hrs following the last administration was 1.25% (0.2% to 3.0%) of the administered dose of mupirocin.[L10580]
|
No information available.
|
No information available.
|
Organic compounds
|
Lipids and lipid-like molecules
|
Fatty Acyls
|
Fatty acids and conjugates
|
[
"approved",
"investigational",
"vet_approved"
] |
[
"R01AX",
"R01A",
"R01",
"R",
"D06AX",
"D06A",
"D06",
"D"
] |
[
"Enteric bacteria and other eubacteria",
"Staphylococcus aureus",
"Streptococcus pyogenes"
] |
[
{
"cost": "1.94",
"description": "Mupirocin 2% ointment",
"unit": "g"
},
{
"cost": "3.37",
"description": "Bactroban 2% ointment",
"unit": "g"
},
{
"cost": "3.57",
"description": "Bactroban 2% cream",
"unit": "g"
},
{
"cost": "3.98",
"description": "Centany 2% ointment",
"unit": "g"
},
{
"cost": "10.03",
"description": "Bactroban nasal 2% ointment",
"unit": "g"
},
{
"cost": "11.5",
"description": "Bactroban Nasal 2% Ointment 1 gm Tube",
"unit": "tube"
},
{
"cost": "44.46",
"description": "Mupirocin 2% Ointment 22 gm Tube",
"unit": "tube"
},
{
"cost": "44.8",
"description": "Mupirocin powder",
"unit": "g"
},
{
"cost": "62.17",
"description": "Bactroban 2% Cream 15 gm Tube",
"unit": "tube"
},
{
"cost": "77.01",
"description": "Bactroban 2% Ointment 22 gm Tube",
"unit": "tube"
},
{
"cost": "92.21",
"description": "Bactroban 2% Cream 30 gm Tube",
"unit": "tube"
},
{
"cost": "0.36",
"description": "Taro-Mupirocin 2 % Ointment",
"unit": "g"
},
{
"cost": "0.55",
"description": "Bactroban 2 % Cream",
"unit": "g"
},
{
"cost": "0.55",
"description": "Bactroban 2 % Ointment",
"unit": "g"
}
] |
[
{
"approved": "2000-01-11",
"country": "United States",
"expires": "2018-07-08",
"number": "6013657"
}
] |
9-[(E)-4-[(2S,3R,4R,5S)-3,4-dihydroxy-5-[[(2S,3S)-3- [(2S,3S)-3-hydroxybutan-2-yl]oxiran-2-yl]methyl] oxan-2-yl]-3-methylbut-2-enoyl]oxynonanoic acid | Mupirocin | Mupirocina | Mupirocine | Mupirocinum | Pseudomonic acid | Pseudomonic acid A | 6.1.1.5 | IleRS | Isoleucyl-tRNA synthetase
|
[
"Bactroban",
"Bactroban",
"Bactroban",
"Bactroban",
"Bactroban",
"Bactroban",
"Bactroban",
"Bactroban",
"Bactroban",
"Bactroban",
"Bactroban",
"Bactroban",
"Bactroban Cream",
"Bactroban Nasal Ointment",
"Centany",
"Centany",
"Centany AT",
"DermacinRx Clorhexacin",
"DermacinRx Surgical PharmaPak",
"Dermawerx Surgical Plus Pak",
"Levocetirizine Dihydrochloride 2% / Mupirocin 2% / Triamcinolone Acetonide 0.025%",
"Lidocaine 2% / Mupirocin 2%",
"Metronidazole 1% / Mupirocin 2%",
"Metronidazole 1% / Mupirocin 2%",
"Metronidazole 1% / Mupirocin 2% /",
"Mupirocin",
"Mupirocin",
"Mupirocin",
"Mupirocin",
"Mupirocin",
"Mupirocin",
"Mupirocin",
"Mupirocin",
"Mupirocin",
"Mupirocin",
"Mupirocin",
"Mupirocin",
"Mupirocin",
"Mupirocin",
"Mupirocin",
"Mupirocin",
"Mupirocin",
"Mupirocin",
"Mupirocin",
"Mupirocin",
"Mupirocin",
"Mupirocin",
"Mupirocin",
"Mupirocin",
"Mupirocin",
"Mupirocin",
"Mupirocin",
"Mupirocin",
"Mupirocin",
"Mupirocin",
"Mupirocin",
"Mupirocin",
"Mupirocin",
"Mupirocin",
"Mupirocin",
"Mupirocin",
"Mupirocin",
"Mupirocin",
"Mupirocin",
"Mupirocin",
"Mupirocin",
"Mupirocin",
"Mupirocin",
"Mupirocin",
"Mupirocin",
"Mupirocin",
"Mupirocin",
"Mupirocin",
"Mupirocin",
"Mupirocin",
"Mupirocin",
"Mupirocin",
"Mupirocin",
"Mupirocin",
"Mupirocin",
"Mupirocin",
"Mupirocin",
"Mupirocin",
"Mupirocin",
"Mupirocin",
"Mupirocin",
"Mupirocin",
"Mupirocin",
"Mupirocin",
"Mupirocin",
"Mupirocin",
"Mupirocin",
"Mupirocin",
"Mupirocin",
"Mupirocin",
"Mupirocin",
"Mupirocin",
"Mupirocin",
"Mupirocin",
"Mupirocin",
"Mupirocin",
"Mupirocin",
"Mupirocin",
"Mupirocin",
"Mupirocin",
"Mupirocin",
"Mupirocin",
"Mupirocin",
"Mupirocin",
"Mupirocin",
"Mupirocin",
"Mupirocin 2%",
"Mupirocin Calcium",
"Mupirocin Calcium",
"Mupirocin Powder",
"NuSurgePak Surgical Prep/CarePak",
"NuSurgePak Surgical Prep/CarePak",
"Pirnuo",
"Pre and Post Sx Pouch",
"PS1 Aciurgy Pack",
"PS2 Aciurgy Pack",
"Stramucin",
"Taro-mupirocin",
"WhyteDerm SurgiPak"
] |
[
"Bactroban Nasal",
"Plasimine",
"Spectroderm",
"T-Bact",
"Turixin"
] |
[
"Dermawerx Surgical Plus Pak",
"WhyteDerm SurgiPak",
"NuSurgePak Surgical Prep/CarePak",
"Metronidazole 1% / Mupirocin 2% /",
"Lidocaine 2% / Mupirocin 2%",
"Levocetirizine Dihydrochloride 2% / Mupirocin 2% / Triamcinolone Acetonide 0.025%",
"Metronidazole 1% / Mupirocin 2%",
"Metronidazole 1% / Mupirocin 2%",
"DermacinRx Surgical PharmaPak",
"DermacinRx Clorhexacin",
"Pre and Post Sx Pouch",
"NuSurgePak Surgical Prep/CarePak",
"PS1 Aciurgy Pack",
"PS2 Aciurgy Pack"
] |
[] |
[] |
[] |
[] |
DB00411
|
Carbamoylcholine
|
Carbamoylcholine, also known as carbachol, is a muscarinic agonist discovered in 1932.[A226315] Carbamoylcholine was initially used as a treatment for migraines,[A226365] induction of diuresis,[A226370] and other parasympathetic effects.
Carbamoylcholine was granted FDA approval on 28 September 1972.[L30245]
|
solid
|
Carbamoylcholine is indicated to induce miosis for surgery and to reduce intraocular pressure elevations in the first 24 hours after cataract surgery.[L30245]
|
Carbamoylcholine is a parasympathomimetic that acts as an agonist of muscarinic and nicotinic receptors.[A226320,L30245] It is more resistant to hydrolysis by acetylcholinesterase than other choline esters leading to a longer duration of action, with significant effects 24 hours after administration.[A226360] Data regarding the therapeutic index of carbamoylcholine is not readily available.[L30245] Patients should be counselled regarding the risk of administering the drug to patients with acute cardiac failure, bronchial asthma, peptic ulcer, hyperthyroidism, gastrointestinal spasm, urinary tract obstruction, or Parkinson's disease.[L30245]
|
Carbamoylcholine is a parasympathomimetic that acts as an agonist of muscarinic and nicotinic receptors.[A226320,L30245] Intraocular administration leads to miosis and decreases intraocular pressure via increased aqueous humour outflow.[A226320,L30245]
|
Choline esters in general are hydrophilic and therefore poorly absorbed through the gastrointestinal tract and are unlikely to cross the blood brain barrier.[A226355,T825] Data regarding the absorption of carbamoylcholine are not readily available.[L30245]
|
The metabolism of carbamoylcholine has not been well described in the literature. It is metabolized to a small extent by acetylcholinesterase.[A226310]
|
Patients experiencing an overdose of carbamoylcholine may experience nausea, sweating, hypotension, hypersalivation, bronchorrhea, miosis, and dyspnea.[A226315] Patients should be treated with symptomatic and supportive treatment. Treatment may include atropine, furosemide, epinephrine, and/or dopamine.[A226315] Some patients may require intubation.[A226315]
The oral LD<sub>50</sub> in mice is 15 mg/kg[L30250] and in rats is 40 mg/kg.[L30255]
|
Data regarding the half life of carbamoylcholine is not readily available.[L30245]
|
Data regarding protein binding of carbamoylcholine is not readily available.[L30245]
|
Data regarding the route of elimination of carbamoylcholine is not readily available.[L30245]
|
Data regarding the volume of distribution of carbamoylcholine is not readily available.[A226315,L30245]
|
Data regarding the clearance of carbamoylcholine is not readily available.[L30245]
| null | null | null | null |
[
"approved"
] |
[
"N07AB",
"N07A",
"N07",
"N",
"S01EB",
"S01E",
"S01",
"S"
] |
[
"Humans and other mammals"
] |
[
{
"cost": "3.07",
"description": "Isopto carbachol 1.5% drops",
"unit": "ml"
},
{
"cost": "3.51",
"description": "Isopto carbachol 3% drops",
"unit": "ml"
},
{
"cost": "32.4",
"description": "Miostat vial",
"unit": "ml"
},
{
"cost": "44.99",
"description": "Isopto Carbachol 1.5% Solution 30ml Bottle",
"unit": "bottle"
},
{
"cost": "48.64",
"description": "Isopto Carbachol 1.5% Solution 15ml Bottle",
"unit": "bottle"
},
{
"cost": "53.1",
"description": "Carbachol 99% powder",
"unit": "g"
},
{
"cost": "61.76",
"description": "Isopto Carbachol 3% Solution 15ml Bottle",
"unit": "bottle"
},
{
"cost": "0.76",
"description": "Isopto Carbachol 1.5 % Solution",
"unit": "ml"
},
{
"cost": "0.91",
"description": "Isopto Carbachol 3 % Solution",
"unit": "ml"
}
] |
[] |
Carbacholine | carbacol | Carbamylcholine | Choline carbamate | CPLA2 | Phospholipase A2 group IVA | PLA2G4 | 3.1.1.7 | AChE
|
[
"Carbachol",
"Carbachol Injection Liq Sc 0.25mg/ml",
"Carbachol Intraocular Solution 0.01%",
"Carbachol Tab 2mg",
"Carbastat",
"Carbastat",
"Isopto Carbachol",
"Isopto Carbachol",
"Isopto Carbachol 1.5%",
"Isopto Carbachol 3%",
"Miostat",
"Miostat Ophthalmic Liq 0.01%"
] |
[
"Carboptic",
"Mioticol"
] |
[] |
[
"P11229",
"P08172",
"Q15822",
"P20309",
"P08173"
] |
[
"P47712",
"P22303"
] |
[] |
[] |
DB00412
|
Rosiglitazone
|
Rosiglitazone is an anti-diabetic drug in the thiazolidinedione class of drugs. It is marketed by the pharmaceutical company GlaxoSmithKline as a stand-alone drug (Avandia) and in combination with metformin (Avandamet) or with glimepiride (Avandaryl). Like other thiazolidinediones, the mechanism of action of rosiglitazone is by activation of the intracellular receptor class of the peroxisome proliferator-activated receptors (PPARs), specifically PPARγ. Rosiglitazone is a selective ligand of PPARγ, and has no PPARα-binding action. Apart from its effect on insulin resistance, it appears to have an anti-inflammatory effect: nuclear factor kappa-B (NFκB) levels fall and inhibitor (IκB) levels increase in patients on rosiglitazone. Recent research has suggested that rosiglitazone may also be of benefit to a subset of patients with Alzheimer's disease not expressing the ApoE4 allele. This is the subject of a clinical trial currently underway.
|
solid
|
Rosiglitazone is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.
|
When rosiglitazone is used as monotherapy, it is associated with increases in total cholesterol, LDL, and HDL. It is also associated with decreases in free fatty acids. Increases in LDL occurred primarily during the first 1 to 2 months of therapy with AVANDIA and LDL levels remained elevated above baseline throughout the trials. In contrast, HDL continued to rise over time. As a result, the LDL/HDL ratio peaked after 2 months of therapy and then appeared to decrease over time.
|
Rosiglitazone acts as a highly selective and potent agonist at peroxisome proliferator activated receptors (PPAR) in target tissues for insulin action such as adipose tissue, skeletal muscle, and liver. Activation of PPAR-gamma receptors regulates the transcription of insulin-responsive genes involved in the control of glucose production, transport, and utilization. In this way, rosiglitazone enhances tissue sensitivity to insulin.
|
The absolute bioavailability of rosiglitazone is 99%. Peak plasma concentrations are observed about 1 hour after dosing. Administration of rosiglitazone with food resulted in no change in overall exposure (AUC), but there was an approximately 28% decrease in C<sub>max</sub> and a delay in T<sub>max</sub> (1.75 hours). These changes are not likely to be clinically significant; therefore, rosiglitazone may be administered with or without food. Maximum plasma concentration (Cmax) and the area under the curve (AUC) of rosiglitazone increase in a dose-proportional manner over the therapeutic dose range.
|
Hepatic. Rosiglitazone is extensively metabolized in the liver to inactive metabolites via N-demethylation, hydroxylation, and conjugation with sulfate and glucuronic acid. In vitro data have shown that Cytochrome (CYP) P450 isoenzyme 2C8 (CYP2C8) and to a minor extent CYP2C9 are involved in the hepatic metabolism of rosiglitazone.
|
Side effects include fluid retention, congestive heart failure (CHF), liver disease
|
3-4 hours (single oral dose, independent of dose)
|
99.8% bound to plasma proteins, primarily albumin.
|
Following oral or intravenous administration of [14C]rosiglitazone maleate, approximately 64% and 23% of the dose was eliminated in the urine and in the feces, respectively.
|
* 17.6 L [oral volume of distribution Vss/F]
* 13.5 L [population mean, pediatric patients]
|
* Oral clearance (CL) = 3.03 ± 0.87 L/hr [1 mg Fasting]
* Oral CL = 2.89 ± 0.71 L/hr [2 mg Fasting]
* Oral CL = 2.85 ± 0.69 L/hr [8 mg Fasting]
* Oral CL = 2.97 ± 0.81 L/hr [8 mg Fed]
* 3.15 L/hr [Population mean, Pediatric patients]
|
Organic compounds
|
Benzenoids
|
Phenol ethers
| null |
[
"approved",
"investigational"
] |
[
"A10BD",
"A10B",
"A10",
"A",
"A10BG",
"A10B",
"A10",
"A",
"A10BD",
"A10B",
"A10",
"A"
] |
[
"Humans and other mammals"
] |
[
{
"cost": "3.22",
"description": "Avandia 2 mg tablet",
"unit": "tablet"
},
{
"cost": "4.72",
"description": "Avandia 4 mg tablet",
"unit": "tablet"
},
{
"cost": "8.69",
"description": "Avandia 8 mg tablet",
"unit": "tablet"
}
] |
[
{
"approved": "1991-03-26",
"country": "United States",
"expires": "2011-09-17",
"number": "5002953"
},
{
"approved": "2000-04-25",
"country": "Canada",
"expires": "2013-09-01",
"number": "2143849"
},
{
"approved": "1994-04-12",
"country": "Canada",
"expires": "2011-04-12",
"number": "1328452"
},
{
"approved": "1999-10-12",
"country": "United States",
"expires": "2016-06-19",
"number": "5965584"
},
{
"approved": "2000-12-26",
"country": "United States",
"expires": "2016-06-19",
"number": "6166042"
},
{
"approved": "2001-09-11",
"country": "United States",
"expires": "2017-08-11",
"number": "6288095"
},
{
"approved": "2008-04-15",
"country": "United States",
"expires": "2020-10-19",
"number": "7358366"
},
{
"approved": "2012-08-07",
"country": "United States",
"expires": "2022-10-07",
"number": "8236345"
}
] |
(±)-5-[p-[2-(methyl-2-pyridylamino)ethoxy]benzyl]-2,4-thiazolidinedione | (RS)-5-{4-[2-(Methyl-2-pyridylamino)ethoxy]benzyl}-2,4-thiazolidinedion | Rosiglitazon | Rosiglitazona | Rosiglitazone | Rosiglitazonum | NR1C3 | Nuclear receptor subfamily 1 group C member 3 | PPAR-gamma | 6.2.1.3 | ACS4 | Arachidonate--CoA ligase | FACL4 | LACS 4 | LACS4 | Long-chain acyl-CoA synthetase 4 | NR1C1 | Nuclear receptor subfamily 1 group C member 1 | PPAR | PPAR-alpha | NR1C2 | NUC1 | NUCI | Nuclear hormone receptor 1 | Nuclear receptor subfamily 1 group C member 2 | Peroxisome proliferator-activated receptor beta | PPAR-beta | PPAR-delta | PPARB | NR2B1 | Nuclear receptor subfamily 2 group B member 1 | Retinoid X receptor alpha | NR2B2 | Nuclear receptor subfamily 2 group B member 2 | Retinoid X receptor beta | NR2B3 | Nuclear receptor subfamily 2 group B member 3 | Retinoid X receptor gamma | 1.14.99.1 | COX-1 | COX1 | Cyclooxygenase-1 | PGH synthase 1 | PGHS-1 | PHS 1 | Prostaglandin H2 synthase 1 | Prostaglandin-endoperoxide synthase 1 | 1.14.14.1 | Cholesterol 25-hydroxylase | CYPIA2 | Cytochrome P(3)450 | Cytochrome P450 4 | Cytochrome P450-P3 | Hydroperoxy icosatetraenoate dehydratase | 1.14.14.- | Cholesterol 25-hydroxylase | CYP2DL1 | CYPIID6 | Cytochrome P450-DB1 | Debrisoquine 4-hydroxylase | 1,4-cineole 2-exo-monooxygenase | 1,8-cineole 2-exo-monooxygenase | 1.14.14.1 | Albendazole monooxygenase (sulfoxide-forming) | Albendazole sulfoxidase | Cholesterol 25-hydroxylase | CYP3A3 | CYPIIIA3 | CYPIIIA4 | Cytochrome P450 3A3 | Cytochrome P450 HLp | Cytochrome P450 NF-25 | Cytochrome P450-PCN1 | Nifedipine oxidase | Quinine 3-monooxygenase | 1,4-cineole 2-exo-monooxygenase | 1.14.13.- | CYPIIB6 | Cytochrome P450 IIB1 | 1.14.14.1 | 4-nitrophenol 2-hydroxylase | CYP2E | CYPIIE1 | Cytochrome P450-J | 1.14.14.1 | CYPIIC8 | Cytochrome P450 form 1 | Cytochrome P450 IIC2 | Cytochrome P450 MP-12 | Cytochrome P450 MP-20 | S-mephenytoin 4-hydroxylase | (R)-limonene 6-monooxygenase | (S)-limonene 6-monooxygenase | (S)-limonene 7-monooxygenase | 1.14.14.1 | Cholesterol 25-hydroxylase | CYP2C10 | CYPIIC9 | Cytochrome P-450MP | Cytochrome P450 MP-4 | Cytochrome P450 MP-8 | Cytochrome P450 PB-1 | S-mephenytoin 4-hydroxylase | Liver-specific organic anion transporter 1 | LST-1 | LST1 | OATP-2 | OATP-C | OATP1B1 | OATP2 | OATPC | Organic anion transporter SLC21A6 | SLC21A6 | SLCO1B1 | Sodium-independent organic anion-transporting polypeptide 2 | Solute carrier family 21 member 6 | 7.6.2.- | ATP-binding cassette sub-family B member 11 | BSEP | Cell growth-inhibiting gene 29 protein | Na(+)/bile acid cotransporter | Na(+)/taurocholate transport protein | NTCP | SLC10A1 | Sodium/taurocholate cotransporting polypeptide | Solute carrier family 10 member 1
|
[
"Avaglim",
"Avaglim",
"Avaglim",
"Avaglim",
"Avaglim",
"Avaglim",
"Avaglim",
"Avaglim",
"Avaglim",
"Avaglim",
"Avandamet",
"Avandamet",
"Avandamet",
"Avandamet",
"Avandamet",
"Avandamet",
"Avandamet",
"Avandamet",
"Avandamet",
"Avandamet",
"Avandamet",
"Avandamet",
"Avandamet",
"Avandamet",
"Avandamet",
"Avandamet",
"Avandamet",
"Avandamet",
"Avandamet",
"Avandamet",
"Avandamet",
"Avandamet",
"Avandaryl",
"Avandaryl",
"Avandaryl",
"Avandaryl",
"Avandaryl",
"Avandaryl",
"Avandaryl",
"Avandaryl",
"Avandaryl",
"Avandaryl",
"Avandaryl",
"Avandaryl",
"Avandaryl",
"Avandaryl",
"Avandia",
"Avandia",
"Avandia",
"Avandia",
"Avandia",
"Avandia",
"Avandia",
"Avandia",
"Avandia",
"Avandia",
"Avandia",
"Avandia",
"Avandia",
"Avandia",
"Avandia",
"Avandia",
"Avandia",
"Avandia",
"Avandia",
"Avandia",
"Avandia",
"Avandia",
"Avandia",
"Avandia",
"Avandia",
"Avandia",
"Avandia",
"Avandia",
"Avandia",
"Avandia",
"Avandia",
"Avandia",
"Avandia",
"Avandia",
"Avandia 2mg",
"Avandia 2mg",
"Avandia 4mg",
"Avandia 4mg",
"Avandia 8mg",
"Avandia 8mg",
"Dom-rosiglitazone",
"Dom-rosiglitazone",
"Dom-rosiglitazone",
"Mylan-rosiglitazone",
"Mylan-rosiglitazone",
"Mylan-rosiglitazone",
"PHL-rosiglitazone",
"PHL-rosiglitazone",
"PHL-rosiglitazone",
"PMS-rosiglitazone",
"PMS-rosiglitazone",
"PMS-rosiglitazone",
"PMS-rosiglitazone-metformin",
"PMS-rosiglitazone-metformin",
"PMS-rosiglitazone-metformin",
"PMS-rosiglitazone-metformin",
"PMS-rosiglitazone-metformin",
"Rosiglitazone",
"Rosiglitazone",
"Rosiglitazone",
"Rosiglitazone Maleate",
"Rosiglitazone Maleate",
"Rosiglitazone Maleate",
"Teva-rosiglitazone",
"Teva-rosiglitazone",
"Teva-rosiglitazone"
] |
[
"Blutab",
"DH-Rosidia",
"Diaben",
"Diaglinex",
"Gaudil",
"Gliximina",
"Naidi",
"Rogelin",
"Roglit",
"Romerol",
"Rosit",
"Rosix",
"Rossini",
"Sensulin",
"Sheng Ao",
"Sheng Min"
] |
[
"Avandamet",
"Avandamet",
"Avandamet",
"Avandamet",
"Avandamet",
"Avandamet",
"Avandamet",
"Avandamet",
"Avandaryl",
"Avandaryl",
"Avandaryl",
"Avandaryl",
"Avandaryl",
"Avandamet",
"Avandamet",
"Avandamet",
"Avandamet",
"Avandaryl",
"Avandaryl",
"Avandaryl",
"Avandaryl",
"Avandaryl",
"Avandaryl",
"Avandamet",
"Avandamet",
"Avandamet",
"Avandamet",
"Avandamet",
"Avandamet",
"Avandaryl",
"Avandaryl",
"Avandaryl",
"Avandamet",
"Avandamet",
"Avandamet",
"Avandamet",
"PMS-rosiglitazone-metformin",
"PMS-rosiglitazone-metformin",
"PMS-rosiglitazone-metformin",
"PMS-rosiglitazone-metformin",
"PMS-rosiglitazone-metformin",
"Avaglim",
"Avaglim",
"Avaglim",
"Avaglim",
"Avaglim",
"Avaglim",
"Avaglim",
"Avaglim",
"Avaglim",
"Avaglim"
] |
[
"P37231",
"O60488",
"Q07869",
"Q03181",
"P19793",
"P28702",
"P48443"
] |
[
"P23219",
"P05177",
"P10635",
"P08684",
"P20813",
"P05181",
"P10632",
"P11712"
] |
[
"P02768"
] |
[
"Q9Y6L6",
"O95342",
"Q14973"
] |
DB00413
|
Pramipexole
|
Pramipexole is a drug used to treat the symptoms of Parkinson's Disease (PD). It is a _non-ergot dopamine agonist_ drug that is efficacious in treating various Parkinson's symptoms such as tremor, rigidity, and bradykinesia (slow movement) [A176867]. It was first approved by the FDA in 1997 [L5882]. Parkinson's Disease is one of the most common neurodegenerative disorders and causes a high level of disability in patients [A176855], leading to increased difficulty in performing activities of daily living due to symptoms that progress over time [A176858]. The prevalence of Parkinson's Disease worldwide has increased from approximately 2.5 million in 1990 to about 6.1 million in 2016 [A176861]. This increase may be attributed to an aging population along with other contributing factors [A176861].
In addition to the above FDA approval for Parkinson's Disease, pramipexole was also approved by the FDA in 2006 for the treatment of Restless Legs Syndrome (RLS) [A176873]. RLS is a sleep-related disorder characterized by unpleasant sensations in the lower extremities, often accompanied by an uncontrollable urge to move the legs [A176876].
|
solid
|
This drug is indicated for the symptomatic treatment of Parkinson’s disease [FDA label]. This drug can be administered as monotherapy or in conjunction with levodopa. It is also indicated for symptomatic treatment of moderate to severe primary Restless Legs Syndrome (RLS) [FDA label].
|
**Parkinson's Disease**
Through the stimulation of dopamine receptors, pramipexole is thought to relieve the symptoms of Parkinson's Disease [FDA label]. The motor symptoms of Parkinson's disease occur partly due to a reduction of dopamine in the substantia nigra of the brain [A176894]. Dopamine is an essential neurotransmitter that has major effects on motor movements in humans.
**Restless Legs Syndrome**
Pramipexole likely restores balance to the dopaminergic system, controlling the symptoms of this condition. Restless legs syndrome is thought to occur, in part, through dysfunction of the dopaminergic system, resulting in unpleasant lower extremity symptoms [A176876], [F4301].
**Other effects**
In addition to the abovementioned effects, animal studies demonstrate that pramipexole blocks dopamine synthesis, release, and turnover. Additionally, this drug is neuroprotective to dopamine neuron degeneration after ischemia or methamphetamine neurotoxicity [F4301].
|
The exact mechanism of action of pramipexole as a treatment for Parkinson's disease is unknown at this time. It is thought, however, that the ability of pramipexole to cause stimulation of the dopamine receptors in the striatum of the brain, a region that receives a vast array of neurological input and is responsible for a wide variety of functions, may be involved[A176891]. Studies performed in animals show that pramipexole influences striatal neuronal transmission rates following activation of dopamine receptors [FDA label].
Pramipexole is considered a non-ergot dopamine agonist that shows specificity and strong activity at the D2 subfamily of dopamine receptors in vitro, binding selectively and dopamine D2 receptors and showing a preference for the dopamine D3 receptor subtype rather than other subtypes [A176873]. The clinical significance of this binding specificity is unknown [FDA label], [A176873].
|
The bioavailability of pramipexole is higher than 90%, indicating a high level of absorption [FDA label].
|
This drug undergoes little metabolism in humans [FDA label].
|
**LD50**
Rat Oral LD 50 >800 mg/kg [F4298].
**Carcinogenicity, mutagenicity, impact on fertility**
Pramipexole was not found to be carcinogenic in 2-year studies on mice and rats at 0.3, 2.2, and 11 times the maximum recommended human dose (MRHD). No increased incidence of tumors was observed [FDA label]. No mutagenicity was detected in various assays, including the Ames test. Finally, pramipexole given to rat models at a dose of 2.5 mg/kg/day (5 times the maximum recommended human dose), increased estrus cycles and inhibited implantation of a fertilized ovum. Decreased levels of prolactin, a hormone necessary for implantation and maintenance of early pregnancy, were measured [FDA label]. The significance of these findings in humans is unknown.
**Pregnancy**
This drug is considered a pregnancy category C drug, showing teratogenic effects in animals. Currently, there no studies of pramipexole in human pregnancy. Animal reproduction studies are not always predictive of human response. This drug should only be used in pregnancy if the potential benefit outweighs the possible fetal risks [FDA label].
**Nursing**
Whether pramipexole is excreted in human milk is unknown. A decision should be made regarding the administration pramipexole during nursing, or whether to discontinue it during nursing, as many drugs are excreted in human milk. The potential exists for risk to the infant if pramipexole is, in fact, excreted in the milk [FDA label].
|
About 8.5-12 hours [FDA label].
|
About 15% bound to plasma proteins [FDA label].
|
The main route of pramipexole elimination, with 90% of a pramipexole dose found in the urine, almost entirely as unchanged drug [FDA label].
|
This drug is extensively distributed in the body with a volume of distribution of approximately 500 L [FDA label].
|
Renal clearance is about 400 mL/min, indicating heavy secretion by the renal tubules [FDA label].
|
Organic compounds
|
Organic nitrogen compounds
|
Organonitrogen compounds
|
Amines
|
[
"approved",
"investigational"
] |
[
"N04BC",
"N04B",
"N04",
"N"
] |
[
"Humans and other mammals"
] |
[
{
"cost": "1.1",
"description": "Mirapex 0.25 mg Tablet",
"unit": "tablet"
},
{
"cost": "1.23",
"description": "Apo-Pramipexole 1 mg Tablet",
"unit": "tablet"
},
{
"cost": "1.23",
"description": "Apo-Pramipexole 1.5 mg Tablet",
"unit": "tablet"
},
{
"cost": "1.23",
"description": "Co Pramipexole 1 mg Tablet",
"unit": "tablet"
},
{
"cost": "1.23",
"description": "Co Pramipexole 1.5 mg Tablet",
"unit": "tablet"
},
{
"cost": "1.23",
"description": "Novo-Pramipexole 1 mg Tablet",
"unit": "tablet"
},
{
"cost": "1.23",
"description": "Novo-Pramipexole 1.5 mg Tablet",
"unit": "tablet"
},
{
"cost": "1.23",
"description": "Pms-Pramipexole 1 mg Tablet",
"unit": "tablet"
},
{
"cost": "1.23",
"description": "Pms-Pramipexole 1.5 mg Tablet",
"unit": "tablet"
},
{
"cost": "1.23",
"description": "Sandoz Pramipexole 1 mg Tablet",
"unit": "tablet"
},
{
"cost": "1.23",
"description": "Sandoz Pramipexole 1.5 mg Tablet",
"unit": "tablet"
},
{
"cost": "2.2",
"description": "Mirapex 1 mg Tablet",
"unit": "tablet"
},
{
"cost": "2.2",
"description": "Mirapex 1.5 mg Tablet",
"unit": "tablet"
},
{
"cost": "2.95",
"description": "Pramipexole di-hcl 0.125 mg tablet",
"unit": "tablet"
},
{
"cost": "2.95",
"description": "Pramipexole di-hcl 0.25 mg tablet",
"unit": "tablet"
},
{
"cost": "2.95",
"description": "Pramipexole di-hcl 0.5 mg tablet",
"unit": "tablet"
},
{
"cost": "2.95",
"description": "Pramipexole di-hcl 1 mg tablet",
"unit": "tablet"
},
{
"cost": "2.95",
"description": "Pramipexole di-hcl 1.5 mg tablet",
"unit": "tablet"
},
{
"cost": "3.07",
"description": "Pramipexole Dihydrochloride 0.125 mg tablet",
"unit": "tablet"
},
{
"cost": "3.07",
"description": "Pramipexole Dihydrochloride 0.25 mg tablet",
"unit": "tablet"
},
{
"cost": "3.07",
"description": "Pramipexole Dihydrochloride 0.5 mg tablet",
"unit": "tablet"
},
{
"cost": "3.07",
"description": "Pramipexole Dihydrochloride 1 mg tablet",
"unit": "tablet"
},
{
"cost": "3.07",
"description": "Pramipexole Dihydrochloride 1.5 mg tablet",
"unit": "tablet"
},
{
"cost": "3.28",
"description": "Mirapex 0.75 mg tablet",
"unit": "tablet"
},
{
"cost": "3.42",
"description": "Mirapex 0.25 mg tablet",
"unit": "tablet"
},
{
"cost": "3.42",
"description": "Mirapex 0.5 mg tablet",
"unit": "tablet"
},
{
"cost": "3.42",
"description": "Mirapex 1 mg tablet",
"unit": "tablet"
},
{
"cost": "3.42",
"description": "Mirapex 1.5 mg tablet",
"unit": "tablet"
},
{
"cost": "3.48",
"description": "Mirapex 0.125 mg tablet",
"unit": "tablet"
},
{
"cost": "9.83",
"description": "Mirapex er 0.375 mg tablet",
"unit": "tablet"
},
{
"cost": "9.83",
"description": "Mirapex er 0.75 mg tablet",
"unit": "tablet"
},
{
"cost": "9.83",
"description": "Mirapex er 1.5 mg tablet",
"unit": "tablet"
},
{
"cost": "9.83",
"description": "Mirapex er 3 mg tablet",
"unit": "tablet"
},
{
"cost": "9.83",
"description": "Mirapex er 4.5 mg tablet",
"unit": "tablet"
},
{
"cost": "0.62",
"description": "Apo-Pramipexole 0.25 mg Tablet",
"unit": "tablet"
},
{
"cost": "0.62",
"description": "Co Pramipexole 0.25 mg Tablet",
"unit": "tablet"
},
{
"cost": "0.62",
"description": "Novo-Pramipexole 0.25 mg Tablet",
"unit": "tablet"
},
{
"cost": "0.62",
"description": "Pms-Pramipexole 0.25 mg Tablet",
"unit": "tablet"
},
{
"cost": "0.62",
"description": "Sandoz Pramipexole 0.25 mg Tablet",
"unit": "tablet"
}
] |
[
{
"approved": "1989-12-12",
"country": "United States",
"expires": "2010-10-08",
"number": "4886812"
},
{
"approved": "2006-11-28",
"country": "Canada",
"expires": "2018-01-16",
"number": "2275379"
},
{
"approved": "1999-12-14",
"country": "United States",
"expires": "2018-01-16",
"number": "6001861"
},
{
"approved": "2001-02-27",
"country": "United States",
"expires": "2018-01-16",
"number": "6194445"
},
{
"approved": "2014-03-25",
"country": "United States",
"expires": "2029-09-08",
"number": "8679533"
},
{
"approved": "2010-04-13",
"country": "United States",
"expires": "2028-04-26",
"number": "7695734"
}
] |
(-)-Pramipexole | (S)-N 6-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine | Pramipexol | Pramipexole | Pramipexolum | Dopamine D3 receptor | Dopamine D2 receptor | D(2C) dopamine receptor | Dopamine D4 receptor | 5-HT-1A | 5-HT1A | ADRB2RL1 | ADRBRL1 | G-21 | Serotonin receptor 1A | ADRA2R | ADRAR | Alpha-2 adrenergic receptor subtype C10 | Alpha-2A adrenoceptor | Alpha-2A adrenoreceptor | Alpha-2AAR | hOCT2 | OCT2 | Organic cation transporter 2 | hOCT1 | OCT1 | Organic cation transporter 1 | EMT | EMTH | Extraneuronal monoamine transporter | OCT3 | Organic cation transporter 3
|
[
"Act Pramipexole",
"Act Pramipexole",
"Act Pramipexole",
"Act Pramipexole",
"Apo-pramipexole",
"Apo-pramipexole",
"Apo-pramipexole",
"Apo-pramipexole",
"Apo-pramipexole",
"Apo-pramipexole",
"Auro-pramipexole",
"Auro-pramipexole",
"Auro-pramipexole",
"Auro-pramipexole",
"Auro-pramipexole",
"Ava-pramipexole",
"Ava-pramipexole",
"Ava-pramipexole",
"Ava-pramipexole",
"Dom-pramipexole",
"Dom-pramipexole",
"Dom-pramipexole",
"Dom-pramipexole",
"Mirapex",
"Mirapex",
"Mirapex",
"Mirapex",
"Mirapex",
"Mirapex",
"Mirapex",
"Mirapex",
"Mirapex",
"Mirapex",
"Mirapex",
"Mirapex",
"Mirapex",
"Mirapex",
"Mirapex",
"Mirapex",
"Mirapex",
"Mirapex",
"Mirapex ER",
"Mirapex ER",
"Mirapex ER",
"Mirapex ER",
"Mirapex ER",
"Mirapex ER",
"Mirapex ER",
"Mirapex ER",
"Mirapex ER",
"Mirapex ER",
"Mirapexin",
"Mirapexin",
"Mirapexin",
"Mirapexin",
"Mirapexin",
"Mirapexin",
"Mirapexin",
"Mirapexin",
"Mirapexin",
"Mirapexin",
"Mirapexin",
"Mirapexin",
"Mirapexin",
"Mirapexin",
"Mirapexin",
"Mirapexin",
"Mirapexin",
"Mirapexin",
"Mirapexin",
"Mirapexin",
"Mirapexin",
"Mirapexin",
"Mirapexin",
"Mirapexin",
"Mirapexin",
"Mirapexin",
"Mirapexin",
"Mirapexin",
"Mirapexin",
"Mirapexin",
"Mirapexin",
"Mylan-pramipexole",
"Mylan-pramipexole",
"Mylan-pramipexole",
"Mylan-pramipexole",
"Ntp-pramipexole",
"Ntp-pramipexole",
"Ntp-pramipexole",
"Ntp-pramipexole",
"Nu-pramipexole",
"Oprymea",
"Oprymea",
"Oprymea",
"Oprymea",
"Oprymea",
"Oprymea",
"Oprymea",
"Oprymea",
"Oprymea",
"Oprymea",
"Oprymea",
"Oprymea",
"Oprymea",
"Oprymea",
"Oprymea",
"Oprymea",
"Oprymea",
"Oprymea",
"Oprymea",
"Oprymea",
"Oprymea",
"Oprymea",
"Oprymea",
"Oprymea",
"Oprymea",
"Oprymea",
"Oprymea",
"Oprymea",
"Oprymea",
"Oprymea",
"Oprymea",
"Oprymea",
"Oprymea",
"Oprymea",
"Oprymea",
"Oprymea",
"Oprymea",
"Oprymea",
"Oprymea",
"Oprymea",
"Oprymea",
"Oprymea",
"Oprymea",
"Oprymea",
"Oprymea",
"Oprymea",
"Oprymea",
"Oprymea",
"Oprymea",
"Oprymea",
"Oprymea",
"Oprymea",
"Oprymea",
"PMS-pramipexole",
"PMS-pramipexole",
"PMS-pramipexole",
"PMS-pramipexole",
"Pramipexole",
"Pramipexole",
"Pramipexole",
"Pramipexole",
"Pramipexole",
"Pramipexole",
"Pramipexole",
"Pramipexole",
"Pramipexole",
"Pramipexole",
"Pramipexole",
"Pramipexole",
"Pramipexole",
"Pramipexole",
"Pramipexole",
"Pramipexole",
"Pramipexole",
"Pramipexole",
"Pramipexole",
"Pramipexole",
"Pramipexole",
"Pramipexole",
"Pramipexole",
"Pramipexole",
"Pramipexole",
"Pramipexole",
"Pramipexole",
"Pramipexole",
"Pramipexole",
"Pramipexole",
"Pramipexole",
"Pramipexole",
"Pramipexole",
"Pramipexole",
"Pramipexole",
"Pramipexole Accord",
"Pramipexole Accord",
"Pramipexole Accord",
"Pramipexole Accord",
"Pramipexole Accord",
"Pramipexole Accord",
"Pramipexole Accord",
"Pramipexole Accord",
"Pramipexole Accord",
"Pramipexole Accord",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole dihydrochloride",
"Pramipexole dihydrochloride",
"Pramipexole dihydrochloride",
"Pramipexole dihydrochloride",
"Pramipexole dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole dihydrochloride",
"Pramipexole dihydrochloride",
"Pramipexole dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole dihydrochloride",
"Pramipexole dihydrochloride",
"Pramipexole dihydrochloride",
"Pramipexole dihydrochloride",
"Pramipexole dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole dihydrochloride",
"Pramipexole dihydrochloride",
"Pramipexole dihydrochloride",
"Pramipexole dihydrochloride",
"Pramipexole dihydrochloride",
"Pramipexole dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole dihydrochloride",
"Pramipexole dihydrochloride",
"Pramipexole dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole dihydrochloride",
"Pramipexole dihydrochloride",
"Pramipexole dihydrochloride",
"Pramipexole dihydrochloride",
"Pramipexole dihydrochloride",
"Pramipexole dihydrochloride",
"Pramipexole dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole Dihydrochloride",
"Pramipexole dihydrochloride",
"Pramipexole dihydrochloride",
"Pramipexole Dihydrochloride Extended-Release",
"Pramipexole Dihydrochloride Extended-Release",
"Pramipexole Dihydrochloride Extended-Release",
"Pramipexole Dihydrochloride Extended-Release",
"Pramipexole Dihydrochloride Extended-Release",
"Pramipexole Dihydrochloride Extended-Release",
"Pramipexole Dihydrochloride Extended-Release",
"Pramipexole Dihydrochloride Extended-Release",
"Pramipexole Dihydrochloride Extended-Release",
"Pramipexole Dihydrochloride Extended-Release",
"Pramipexole Dihydrochloride Extended-Release",
"Pramipexole Dihydrochloride Extended-Release",
"Pramipexole Dihydrochloride Extended-Release",
"Pramipexole Dihydrochloride Extended-Release",
"Pramipexole Teva",
"Pramipexole Teva",
"Pramipexole Teva",
"Pramipexole Teva",
"Pramipexole Teva",
"Pramipexole Teva",
"Pramipexole Teva",
"Pramipexole Teva",
"Pramipexole Teva",
"Pramipexole Teva",
"Pramipexole Teva",
"Pramipexole Teva",
"Pramipexole Teva",
"Pramipexole Teva",
"Pramipexole Teva",
"Pramipexole Teva",
"Pramipexole Teva",
"Pramipexole Teva",
"Pramipexole Teva",
"Pramipexole Teva",
"Pramipexole Teva",
"Pramipexole Teva",
"Pramipexole Teva",
"Pramipexole Teva",
"Sandoz Pramipexole",
"Sandoz Pramipexole",
"Sandoz Pramipexole",
"Sandoz Pramipexole",
"Sifrol",
"Sifrol",
"Sifrol",
"Sifrol",
"Sifrol",
"Sifrol",
"Sifrol",
"Sifrol",
"Sifrol",
"Sifrol",
"Sifrol",
"Sifrol",
"Sifrol",
"Sifrol",
"Sifrol",
"Sifrol",
"Sifrol",
"Sifrol",
"Sifrol",
"Sifrol",
"Sifrol",
"Sifrol",
"Sifrol",
"Sifrol",
"Sifrol",
"Sifrol",
"Sifrol",
"Sifrol",
"Sifrol",
"Sifrol",
"Sifrol",
"Teva-pramipexole",
"Teva-pramipexole",
"Teva-pramipexole",
"Teva-pramipexole"
] |
[
"Glepark",
"Medopexol",
"Miramel",
"Miraper",
"Pexola",
"Sifrol ER"
] |
[
"Mirapex ER",
"Mirapex ER",
"Mirapex ER"
] |
[
"P35462",
"P14416",
"P21917",
"P08908",
"P08913"
] |
[] |
[] |
[
"O15244",
"O15245",
"O75751"
] |
DB00414
|
Acetohexamide
|
A sulfonylurea hypoglycemic agent that is metabolized in the liver to 1-hydrohexamide. Acetohexamide has been discontinued in the US market.
|
solid
|
Used in the management of diabetes mellitus type 2 (adult-onset).
|
Acetohexamide is an intermediate-acting, first-generation oral sulfonylurea. It lowers blood sugar by stimulating the pancreatic beta cells to secrete insulin and by helping the body use insulin efficiently. Due to its primary action on the pancreatic beta cells, the drug is only effective when there are functional pancreatic beta cells that can produce insulin granules. Acetohexamide has one-third the potency of chlorpropamide, and twice the potency of tolbutamide; however, similar hypoglycemic efficacy occurs with equipotent dosage of sulfonylureas.
|
Sulfonylureas such as acetohexamide bind to an ATP-dependent K<sup>+</sup> channel on the cell membrane of pancreatic beta cells. This inhibits a tonic, hyperpolarizing outflux of potassium, which causes the electric potential over the membrane to become more positive. This depolarization opens voltage-gated Ca<sup>2+</sup> channels. The rise in intracellular calcium leads to increased fusion of insulin granulae with the cell membrane, and therefore increased secretion of (pro)insulin.
|
Rapidly absorbed from the GI tract.
|
Extensively metabolized in the liver to the active metabolite hydroxyhexamide, which exhibits greater hypoglycemic potency than acetohexamide. Hydroxyhexamide is believed to be responsible for prolonged hypoglycemic effects.
|
Oral, rat LD<sub>50</sub>: 5 gm/kg; Oral, mouse LD<sub>50</sub>: >2500 mg/kg. Symptoms of an acetohexamide overdose include hunger, nausea, anxiety, cold sweats, weakness, drowsiness, unconsciousness, and coma.
|
Elimination half-life of the parent compound is 1.3 hours and the elimination half-life of the active metabolite is approximately 5-6 hours.
|
90%
| null | null | null |
Organic compounds
|
Organic oxygen compounds
|
Organooxygen compounds
|
Carbonyl compounds
|
[
"approved",
"investigational",
"withdrawn"
] |
[
"G01AE",
"G01A",
"G01",
"G",
"A10BB",
"A10B",
"A10",
"A"
] |
[
"Humans and other mammals"
] |
[] |
[] |
1-((p-Acetylphenyl)sulfonyl)-3-cyclohexylurea | 1-[(4-acetylbenzene)sulfonyl]-3-cyclohexylurea 4-acetyl-N-(cyclohexylcarbamoyl)benzenesulfonamide | Acetohexamid | Acetohexamida | Acétohexamide | Acetohexamide | Acetohexamidum | N-(p-Acetylphenylsulfonyl)-N'-cyclohexylurea | ATP-regulated potassium channel ROM-K | Inward rectifier K(+) channel Kir1.1 | Potassium channel, inwardly rectifying subfamily J member 1 | ROMK1 | HRINS | Sulfonylurea receptor 1 | SUR | SUR1 | (R)-limonene 6-monooxygenase | (S)-limonene 6-monooxygenase | (S)-limonene 7-monooxygenase | 1.14.14.1 | Cholesterol 25-hydroxylase | CYP2C10 | CYPIIC9 | Cytochrome P-450MP | Cytochrome P450 MP-4 | Cytochrome P450 MP-8 | Cytochrome P450 PB-1 | S-mephenytoin 4-hydroxylase | 1.1.1.184 | 15-hydroxyprostaglandin dehydrogenase [NADP(+)] | 20-beta-hydroxysteroid dehydrogenase | Alcohol dehydrogenase [NAD(P)+] CBR1 | CBR | CRN | NADPH-dependent carbonyl reductase 1 | PG-9-KR | Prostaglandin 9-ketoreductase | Prostaglandin-E(2) 9-reductase | SDR21C1 | Short chain dehydrogenase/reductase family 21C member 1
|
[
"Dimelor Tablet 1843 500mg"
] |
[
"Acetohexamide",
"Dimelin",
"Dymelor",
"Gamadiabet"
] |
[] |
[
"P48048",
"Q09428"
] |
[
"P11712",
"P16152"
] |
[
"P02768"
] |
[] |
DB00415
|
Ampicillin
|
Ampicillin is a semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.
|
solid
|
For treatment of infection (Respiratory, GI, UTI and meningitis) due to E. coli, P. mirabilis, enterococci, Shigella, S. typhosa and other Salmonella, nonpenicillinase-producing N. gononhoeae, H. influenzae, staphylococci, streptococci including streptoc
|
Ampicillin is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. The name "penicillin" can either refer to several variants of penicillin available, or to the group of antibiotics derived from the penicillins. Ampicillin has <i>in vitro</i> activity against gram-positive and gram-negative aerobic and anaerobic bacteria. The bactericidal activity of Ampicillin results from the inhibition of cell wall synthesis and is mediated through Ampicillin binding to penicillin binding proteins (PBPs). Ampicillin is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, and cephalosporinases and extended spectrum beta-lactamases.
|
By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, Ampicillin inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that Ampicillin interferes with an autolysin inhibitor.
| null | null | null | null | null |
Ampicillin is excreted largely unchanged in the urine.
| null | null |
Organic compounds
|
Organoheterocyclic compounds
|
Lactams
|
Beta lactams
|
[
"approved",
"vet_approved"
] |
[
"J01CR",
"J01C",
"J01",
"J",
"J01CA",
"J01C",
"J01",
"J",
"J01CA",
"J01C",
"J01",
"J",
"S01AA",
"S01A",
"S01",
"S"
] |
[
"Enteric bacteria and other eubacteria",
"Listeria monocytogenes",
"Haemophilus influenzae",
"Gram-positive Bacteria",
"Streptococcus pneumoniae",
"Streptococcus pyogenes",
"Gram-negative Bacteria",
"Neisseria meningitidis"
] |
[
{
"cost": "2.15",
"description": "Ampicillin Sodium 250 mg/vial",
"unit": "vial"
},
{
"cost": "2.26",
"description": "Ampicillin Sodium 500 mg/vial",
"unit": "vial"
},
{
"cost": "3.53",
"description": "Ampicillin tr 250 mg capsule",
"unit": "capsule"
},
{
"cost": "3.78",
"description": "Ampicillin Sodium 1 g/vial",
"unit": "vial"
},
{
"cost": "7.56",
"description": "Ampicillin Sodium 2 g/vial",
"unit": "vial"
},
{
"cost": "7.99",
"description": "Principen 250 mg/5ml Suspension 100ml Bottle",
"unit": "bottle"
},
{
"cost": "8.64",
"description": "Ampicillin 1 gm vial",
"unit": "vial"
},
{
"cost": "16.27",
"description": "Principen 250 mg/5ml Suspension 200ml Bottle",
"unit": "bottle"
},
{
"cost": "16.75",
"description": "Ampicillin 2 gm vial",
"unit": "vial"
},
{
"cost": "107.77",
"description": "Ampicillin 10 gm vial",
"unit": "vial"
},
{
"cost": "0.44",
"description": "Ampicillin 250 mg capsule",
"unit": "capsule"
},
{
"cost": "0.5",
"description": "Ampicillin 500 mg capsule",
"unit": "capsule"
},
{
"cost": "0.61",
"description": "Ampicillin tr 500 mg capsule",
"unit": "capsule"
}
] |
[] |
ABPC | Aminobenzylpenicillin | Ampicilina | Ampicillin | Ampicillin (anhydrous) | Ampicillin acid | Ampicillin anhydrous | Ampicillin, anhydrous | Ampicilline | Ampicillinum | Anhydrous ampicillin | AP | D-(−)-6-(α-aminophenylacetamido)penicillanic acid | D-(−)-ampicillin | Putative D-alanyl-D-alanine carboxypeptidase | exp2 | Exported protein 2 | PBP-1A | pbp2b | Intestinal H(+)/peptide cotransporter | Oligopeptide transporter, small intestine isoform | PEPT1 | Peptide transporter 1 | Kidney H(+)/peptide cotransporter | Oligopeptide transporter, kidney isoform | PEPT2 | Peptide transporter 2 | 2.7.10.1 | Endothelial tyrosine kinase | hTIE2 | p140 TEK | TIE2 | Tunica interna endothelial cell kinase | Tyrosine kinase with Ig and EGF homology domains-2 | Tyrosine-protein kinase receptor TEK | Tyrosine-protein kinase receptor TIE-2 | VMCM | VMCM1 | High-affinity sodium-dependent carnitine cotransporter | OCTN2 | Solute carrier family 22 member 5 | Intestinal H(+)/peptide cotransporter | Oligopeptide transporter, small intestine isoform | PEPT1 | Peptide transporter 1 | Kidney H(+)/peptide cotransporter | Oligopeptide transporter, kidney isoform | PEPT2 | Peptide transporter 2 | MCT 1 | MCT1 | Solute carrier family 16 member 1
|
[
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"Ampicillin",
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"Ampicillin",
"Ampicillin",
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"Ampicillin",
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"Ampicillin",
"Ampicillin",
"Ampicillin",
"Ampicillin",
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"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
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"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
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"Ampicillin and Sulbactam",
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"Ampicillin and Sulbactam",
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"Ampicillin and Sulbactam",
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"Ampicillin and Sulbactam",
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"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"AMPICILLIN and SULBACTAM",
"AMPICILLIN and SULBACTAM",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin for Injection",
"Ampicillin for Injection, USP",
"Ampicillin for Injection, USP",
"Ampicillin for Injection, USP",
"Ampicillin for Injection, USP",
"Ampicillin for Injection, USP",
"Ampicillin for Injection, USP",
"Ampicillin for Injection, USP",
"Ampicillin for Injection, USP",
"Ampicillin for Injection, USP",
"Ampicillin Sodium",
"Ampicillin Sodium",
"Ampicillin sodium",
"Ampicillin Sodium and Sulbactam Sodium",
"Ampicillin Sodium and Sulbactam Sodium",
"Ampicillin Sodium and Sulbactam Sodium",
"Ampicillin Sodium and Sulbactam Sodium",
"Ampicillin Sodium and Sulbactam Sodium",
"Ampicillin Sodium and Sulbactam Sodium",
"Ampicillin Sodium and Sulbactam Sodium",
"Ampicillin Sodium and Sulbactam Sodium",
"Ampicillin Sodium and Sulbactam Sodium",
"Ampicillin Sodium and Sulbactam Sodium",
"Ampicillin Sodium and Sulbactam Sodium",
"Ampicillin Sodium and Sulbactam Sodium",
"Ampicillin Sodium for Injection BP",
"Ampicillin Sodium for Injection BP",
"Ampicillin Sodium for Injection BP",
"Ampicillin Sodium for Injection BP",
"Ampicillin Sodium for Injection BP",
"Ampicillin Sodium for Injection BP",
"Ampicillin Sodium for Injection BP",
"Ampicillin Sodium for Injection BP",
"Ampicillin Sodium for Injection, BP",
"Ampicillin Sodium for Injection, BP",
"Ampicillin Sodium for Injection, BP",
"Ampicillin Sodium for Injection, BP",
"Ampicillin Sodium for Injection, USP",
"Ampicillin Sodium for Injection, USP",
"Ampicillin Sodium for Injection, USP",
"Ampicillin Sodium for Injection, USP",
"Ampicillin Trihydrate",
"Ampicillin Trihydrate",
"Ampicin for Injection 250mg",
"Ampicin Inj 125mg/vial",
"Ampicin Inj 1gm",
"Ampicin Inj 2000mg",
"Ampicin Inj 500mg",
"Apo Ampi Capsules 250mg",
"Apo Ampi Capsules 500mg",
"Apo Ampi Liq 125mg/5ml",
"Apo Ampi Liq 250mg/5ml",
"Jaa Amp Tab 125mg",
"Novo-ampicillin Pws 500mg/5ml",
"Novo-ampicillin Sus 125mg/5ml",
"Novo-ampicillin Sus 250mg/5ml",
"Nu-ampi Capsules 250mg",
"Nu-ampi Capsules 500mg",
"Nu-ampi Sus 125mg/5ml",
"Nu-ampi Suspension 250mg/5ml",
"Penbritin Cap 250mg",
"Penbritin Cap 500mg",
"Penbritin Inj 1000mg",
"Penbritin Inj 2000mg",
"Penbritin Inj 250mg",
"Penbritin Inj 500mg",
"Penbritin Pws 250mg/5ml",
"Penbritin-1000 Pws 1000mg/vial",
"Penbritin-125 Pws 125mg/vial",
"Penbritin-250 Pws Im/iv 250mg/vial",
"Pro Ampi 250 Cap 250mg",
"Pro Ampi 500 Cap 500mg",
"Pro Biosan Kit",
"Sterile Ampicillin Sodium 250mg USP",
"Taro-ampicillin Cap 250mg",
"Taro-ampicillin Cap 500mg",
"Teva-ampicillin",
"Teva-ampicillin",
"Unasyn",
"Unasyn",
"Unasyn",
"Unasyn",
"Unasyn",
"Unasyn",
"Unasyn"
] |
[
"Austrapen",
"Binotal",
"Penbritin",
"Principen",
"Redicilin",
"Semicillin",
"Tokiocillin",
"Ultrabion",
"Viccillin"
] |
[
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin Sodium and Sulbactam Sodium",
"Ampicillin Sodium and Sulbactam Sodium",
"Ampicillin Sodium and Sulbactam Sodium",
"Ampicillin Sodium and Sulbactam Sodium",
"Ampicillin Sodium and Sulbactam Sodium",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin Sodium and Sulbactam Sodium",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Unasyn",
"Unasyn",
"Unasyn",
"Unasyn",
"Unasyn",
"Unasyn",
"Unasyn",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Pro Biosan Kit",
"Ampicillin and Sulbactam",
"Ampicillin Sodium and Sulbactam Sodium",
"Ampicillin Sodium and Sulbactam Sodium",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"AMPICILLIN and SULBACTAM",
"AMPICILLIN and SULBACTAM",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin Sodium and Sulbactam Sodium",
"Ampicillin Sodium and Sulbactam Sodium",
"Ampicillin Sodium and Sulbactam Sodium",
"Ampicillin and Sulbactam",
"Ampicillin Sodium and Sulbactam Sodium",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam",
"Ampicillin and Sulbactam"
] |
[
"P46059",
"Q16348",
"Q02763"
] |
[] |
[
"P02768"
] |
[
"O76082",
"P46059",
"Q16348",
"P53985"
] |
DB00416
|
Metocurine iodide
|
Metocurine iodide is a benzylisoquinolinium competitive nondepolarizing neuromuscular blocking agent. It is used as an anesthesia adjunct to induce skeletal muscle relaxation and to reduce the intensity of muscle contractions in convulsive therapy Metocurine iodide has a moderate risk of inducing histamine release and has some ganglion blocking activity. Metocurine iodide can be used most advantageously if muscle twitch response to peripheral nerve stimulation is monitored to assess degree of muscle relaxation. Metocurine Iodide is no longer available on the US market.
|
solid
|
For use as an anesthesia adjunct to induce skeletal muscle relaxation and to reduce the intensity of muscle contractions in convulsive therapy.
|
Metocurine iodide is a benzylisoquinolinium competitive nondepolarizing neuromuscular blocking agent. Metocurine iodide has a moderate risk of inducing histamine release and has some ganglion blocking activity. Metocurine iodide can be used most advantageously if muscle twitch response to peripheral nerve stimulation is monitored to assess degree of muscle relaxation. As with other nondepolarizing neuromuscular blockers, the time to onset of paralysis decreases and the duration of maximum effect increases with increasing doses of metocurine iodide. Repeated administration of maintenance doses of metocurine iodide has no cumulative effect on the duration of neuromuscular block if recovery is allowed to begin prior to repeat dosing. Moreover, the time needed to recover from repeat doses does not change with additional doses. Repeat doses can therefore be administered at relatively regular intervals with predictable results.
|
Metocurine iodide antagonizes the neurotransmitter action of acetylcholine by binding competitively with cholinergic receptor sites on the motor end-plate. This antagonism is inhibited, and neuromuscular block reversed, by acetylcholinesterase inhibitors such as neostigmine, edrophonium, and pyridostigmine.
| null | null |
Excessive doses can be expected to produce enhanced pharmacological effects. Overdosage may increase the risk of histamine release and cardiovascular effects, especially hypotension.
|
3 to 4 hours
|
35% in plasma
| null | null | null |
Organic compounds
|
Organic oxygen compounds
|
Organooxygen compounds
|
Ethers
|
[
"approved",
"withdrawn"
] |
[] |
[
"Humans and other mammals"
] |
[] |
[] |
Dimethyl tubocurarine iodide | Dimethylchondrocurarine iodide | Dimethyltubocurarinium iodide | Metocurine iodide | Metocurini iodidum | Metubine iodide | NACRA4
|
[
"Metubine Iodide Inj 2mg/ml"
] |
[] |
[] |
[
"P43681",
"P17787",
"Q15822"
] |
[] |
[] |
[] |
DB00417
|
Phenoxymethylpenicillin
|
Phenoxymethylpenicillin is a narrow spectrum antibiotic also commonly referred to as Penicillin V or Penicillin VK.[A178609] It is a phenoxymethyl analog of Penicillin G, or [benzylpenicillin]. An orally active naturally penicillin, phenoxymethylpenicillin is used to treat mild to moderate infections in the respiratory tract, skin, and soft tissues caused by penicillin G-sensitive microorganisms. Phenoxymethylpenicillin has also be used in some cases as prophylaxis against susceptible organisms. While there have been no controlled clinical efficacy studies that were conducted, phenoxymethylpenicillin has been suggested by the American Heart Association and the American Dental Association for use as an oral regimen for prophylaxis against bacterial endocarditis in patients with congenital heart disease or rheumatic or other acquired valvular heart disease when they undergo dental procedures and surgical procedures of the upper respiratory tract, except for those who are at an elevated risk for endocarditis.[label]
|
solid
|
Indicated for the treatment of mild to moderately severe infections due to penicillin G-sensitive microorganisms, with the use of bacteriological studies (including sensitivity tests) and clinical response.[label]
Phenoxymethylpenicillin may be used for the treatment of:
- mild to moderate infections of the upper respiratory tract, scarlet fever, and mild erysipelas caused by Streptococcus without bacteremia
- mild to moderately severe infections of the respiratory tract caused by Pneumococcus
- mild infections of the skin and soft tissues caused by penicillin G-sensitive Staphylococcus
- mild to moderately severe infections of the oropharynx caused by Fusospirochetosis, including Vincent’s gingivitis and pharyngitis, usually respond to oral penicillin therapy
**Off-label**
Indicated for use as prophylaxis against bacterial endocarditis in patients with congenital heart disease or rheumatic or other acquired valvular heart disease when they undergo dental procedures and surgical procedures of the upper respiratory tract.[label]
|
Phenoxymethylpenicillin works against penicillin-sensitive microorganisms with bactericidal effects. It targets the bacteria during its active multiplication stage by interfering with bacterial cell wall peptidoglycan synthesis. _In vitro_, phenoxymethylpenicillin was shown to be active against staphylococci (except penicillinase-producing strains), streptococci (groups A, C, G, H, L and M), and pneumococci, as well as _Corynebacterium diphtheriae_, _Bacillus anthracis_, Clostridia, _Actinomyces bovis_, _Streptobacillus moniliformis_, _Listeria monocytogenes_, _Leptospira_, _Neisseria gonorrhoeae_, and _Treponema pallidum_.[label]
|
Phenoxymethylpenicillin inhibits the biosynthesis of cell wall mucopeptide [label] by binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, which are critical in the cell wall synthesis and maintenance, as well as cell division.[L6412] This disrupts the third and last stage of bacterial cell wall synthesis. This subsequently leads to cell lysis.[L6412]
|
Upon oral administration, phenoxymethylpenicillin is rapidly but incompletely absorbed.[A178612] The bioavailability of phenoxymethylpenicillin ranges from 25 to 60%.[A178618] Compared to the free acid form of the drug, the calcium or potassium salts of phenoxymethylpenicillin displays better absorption profiles. It is reported that fasting state enhances the drug absorption. The peak plasma concentrations of 200 to 700 ng/mL are achieved in 2 hours following an oral dose of 125 mg. Following an oral dose of 500 mg, the peak plasma concentrations of 3 to 5 μg/mL are reached in 30 to 60 minutes post-dose.[L6412]
|
About 35-70% of an oral dose is metabolized to penicilloic acid, an inactive metabolite. Small amounts of 6-aminopenicillanic acid have been recovered in the urine of patients on penicillin G. A small percentage of the drug appears to be hydroxylated into one or more active metabolites, which are also excreted via urine.
|
The oral LD<sub>50</sub> is >1040 mg/kg in rats. Nausea, vomiting, black hairy tongue, and epigastric distress are common reactions to oral penicillins.[label] In rare cases, neuromuscular sensitivity and seizures may be seen with antibiotics and supportive treatments are advised and further drug absorption should be limited through induced emesis or gastric lavage, followed by administration of activated charcoal.[L6418] Severe hypersensitivity reactions, often leading to death, have been reported with penicillin therapies.[label] Although phenoxymethylpenicillin was shown to be excreted in human breast milk, the use of this drug in pregnant or nursing women is regarded generally safe.[L6415]
|
Upon oral administration, the half-life is about 30 minutes. It can last up to 4 hours in patients with renal impairment.[L6412]
|
Upon oral administration, about 50-80% of the drug is bound to plasma proteins.[L6412,label]
|
While the drug is rapidly excreted, only 25% of the total dose is detected in the urine. Renal excretion may be delayed in neonates, young infants, and patients with renal impairment.[label]
|
Following intravenous administration, the volume of distribution at steady state was 35.4 L.[A178615] Small amounts of the drug can be found in various tissues, with the highest amount found in the kidneys, with lesser amounts in the liver, skin, and intes tines. Phenoxymethylpenicillin was found in the cerebrospinal fluid.[label] Phenoxymethylpenicillin was detectable in the placenta and human breast milk.[L6412]
| null |
Organic compounds
|
Organic acids and derivatives
|
Carboxylic acids and derivatives
|
Amino acids, peptides, and analogues
|
[
"approved",
"vet_approved"
] |
[
"J01CR",
"J01C",
"J01",
"J",
"J01CE",
"J01C",
"J01",
"J",
"J01CE",
"J01C",
"J01",
"J"
] |
[
"Bacteria",
"Gram-negative Bacteria",
"Streptococcus pyogenes",
"Bacillus anthracis",
"Borrelia burgdorferi",
"Corynebacterium diphtheriae",
"Clostridium",
"Listeria monocytogenes",
"Leptospira interrogans",
"Neisseria gonorrhoeae"
] |
[
{
"cost": "12.99",
"description": "Penicillin V Potassium 250 mg/5ml Solution 100ml Bottle",
"unit": "bottle"
},
{
"cost": "0.06",
"description": "Apo-Pen-Vk 25 mg/ml Liquid",
"unit": "ml"
},
{
"cost": "0.06",
"description": "Apo-Pen-Vk 60 mg/ml Liquid",
"unit": "ml"
},
{
"cost": "0.06",
"description": "Novo-Pen-Vk 60 mg/ml Liquid",
"unit": "ml"
},
{
"cost": "0.07",
"description": "Apo-Pen-Vk 300 mg Tablet",
"unit": "tablet"
},
{
"cost": "0.07",
"description": "Novo-Pen-Vk 300 mg Tablet",
"unit": "tablet"
},
{
"cost": "0.07",
"description": "Nu-Pen-Vk 300 mg Tablet",
"unit": "tablet"
},
{
"cost": "0.23",
"description": "Penicillin vk 250 mg tablet",
"unit": "tablet"
},
{
"cost": "0.24",
"description": "Veetids 250 mg tablet",
"unit": "tablet"
},
{
"cost": "0.4",
"description": "Penicillin vk 500 mg tablet",
"unit": "tablet"
},
{
"cost": "0.43",
"description": "Veetids 500 mg tablet",
"unit": "tablet"
},
{
"cost": "0.47",
"description": "Penicillin V Potassium 250 mg tablet",
"unit": "tablet"
},
{
"cost": "0.77",
"description": "Penicillin V Potassium 500 mg tablet",
"unit": "tablet"
}
] |
[] |
(2S,5R,6R)-3,3-DIMETHYL-7-OXO-6-(2-PHENOXYACETAMIDO)-4-THIA-1- AZABICYCLO(3.2.0)HEPTANE-2-CARBOXYLIC ACID | (2S,5R,6R)-3,3-dimethyl-7-oxo-6-[(phenoxyacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid | 6-phenoxyacetamidopenicillanic acid | Fenoximetilpenicilina | Oracillin | Penicillin Phenoxymethyl | Penicillin V | Phenoxomethylpenicillin | Phenoxymethyl Penicillin | Phenoxymethylenepenicillinic acid | Phenoxymethylpenicillin | Phénoxyméthylpénicilline | Phenoxymethylpenicillinum | PV | PBP2A | PBP1 | 3.4.16.4 | D-alanyl-D-alanine endopeptidase | DD-carboxypeptidase | DD-endopeptidase | PBP-4 | Penicillin-binding protein 4 | 3.5.1.11 | Penicillin V amidase | PVA | Intestinal H(+)/peptide cotransporter | Oligopeptide transporter, small intestine isoform | PEPT1 | Peptide transporter 1
|
[
"Apo Pen Vk",
"Apo Pen Vk",
"Beepen-VK",
"Beepen-VK",
"Beepen-VK",
"Beepen-VK",
"Ledercillin Vk - Tab 400000 Unit",
"Ledercillin Vk - Tab 800000units",
"Ledercillin Vk Tab 400000unit",
"Ledercillin Vk Tab 800000unit",
"Nadopen V 200",
"Nadopen V 400",
"Nadopen V Tab 500000iu",
"Novo-pen Vk Syr 500000/5ml",
"Novo-pen-VK 500 Tab",
"Nu-pen-VK Tablets 300mg",
"Pen Vee Sus 180mg",
"Pen Vk-125 Sus 200000unit/5ml",
"Pen Vk-300 Sus 500000unit/5ml",
"Pen-vee Oral Tablets 300 mg",
"Pen-vee Suspension 180 mg",
"Pen-vee Suspension 180mg/5ml",
"Pen-vee Suspension 300 mg",
"Pen-vee Suspension 300mg/5ml",
"Pen-vee-oral Tablets 300mg",
"Pen-VK",
"Penicillin V Potasium",
"Penicillin V Potasium",
"Penicillin V Potasium",
"Penicillin V Potasium",
"Penicillin V Potasium",
"Penicillin V Potasium",
"Penicillin V Potasium",
"Penicillin V Potasium",
"Penicillin V Potasium",
"Penicillin V Potasium",
"Penicillin V Potasium",
"Penicillin V Potasium",
"Penicillin V Potasium",
"Penicillin V Potasium",
"Penicillin V Potasium",
"Penicillin V Potasium",
"Penicillin V Potasium",
"Penicillin V Potasium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicillin V Potassium",
"Penicilline V 300 Tab",
"Pvf 250sus",
"Pvf 500sus",
"Pvf K500tab",
"Pvf-K 500 Tablets",
"V Cillin K 1831 Tablet 250mg"
] |
[
"Apo-Pen-VK",
"Betapen-VK",
"Crystapen V",
"Distaquaine V",
"Fenospen",
"Fenoxypen",
"Ledercillin VK",
"Oratren",
"Ospen",
"Pen-Oral",
"Pen-V",
"Pen-Vee",
"Pen-Vee K",
"Penicillin VK",
"Pfizerpen VK",
"Phenocillin",
"Robicillin VK",
"Rocilin",
"Uticillin VK",
"V-Cillin",
"Veetids"
] |
[] |
[
"P46059"
] |
[] |
[] |
[] |
DB00418
|
Secobarbital
|
Secobarbital (marketed by Eli Lilly and Company under the brand names Seconal and Tuinal) is a barbiturate derivative drug with anaesthetic, anticonvulsant, sedative and hypnotic properties. It is commonly known as quinalbarbitone in the United Kingdom.
|
solid
|
For the Short-term treatment of intractable insomnia for patients habituated to barbiturates
|
Secobarbital, a barbiturate, is used for the induction of anesthesia prior to the use of other general anesthetic agents and for induction of anesthesia for short surgical, diagnostic, or therapeutic procedures associated with minimal painful stimuli. Little analgesia is conferred by barbiturates; their use in the presence of pain may result in excitation.
|
Secobarbital binds at a distinct binding site associated with a Cl<sup>-</sup> ionopore at the GABA<sub>A</sub> receptor, increasing the duration of time for which the Cl<sup>-</sup> ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged.
| null | null |
Symptoms of an overdose typically include sluggishness, incoordination, difficulty in thinking, slowness of speech, faulty judgment, drowsiness or coma, shallow breathing, staggering, and in severe cases coma and death.
| null | null |
Barbiturates are metabolized primarily by the hepatic microsomal enzyme system, and the metabolic products are excreted in the urine and, less commonly, in the feces.
| null | null |
Organic compounds
|
Organoheterocyclic compounds
|
Diazines
|
Pyrimidines and pyrimidine derivatives
|
[
"approved",
"vet_approved"
] |
[
"N05CB",
"N05C",
"N05",
"N",
"N05CA",
"N05C",
"N05",
"N"
] |
[
"Humans and other mammals"
] |
[
{
"cost": "4.91",
"description": "Seconal sodium 100 mg capsule",
"unit": "capsule"
},
{
"cost": "5.23",
"description": "Seconal 100 mg capsule",
"unit": "capsule"
},
{
"cost": "0.93",
"description": "Seconal sodium 100 mg pulvul",
"unit": "each"
}
] |
[] |
(±)-secobarbital | 5-(1-methylbutyl)-5-(2-propenyl)-2,4,6(1H,3H,5H)-pyrimidinetrione | 5-allyl-5-(1-methylbutyl)-2,4,6(1H,3H,5H)-pyrimidinetrione | 5-allyl-5-(1-methylbutyl)barbituric acid | 5-allyl-5-(1-methylbutyl)pyrimidine-2,4,6(1H,3H,5H)-trione | Quinalbarbitone | Secobarbital | Secobarbitalum | Secobarbitone | GABA(A) receptor subunit alpha-2 | GABAAR subunit alpha-2 | GABA(A) receptor subunit alpha-3 | GABAAR subunit alpha-3 | GABA(A) receptor subunit alpha-4 | GABAAR subunit alpha-4 | GABA(A) receptor subunit alpha-5 | GABAAR subunit alpha-5 | GABA(A) receptor subunit alpha-6 | GABAAR subunit alpha-6 | GABA(A) receptor subunit alpha-1 | GABAAR subunit alpha-1 | NACRA4 | NACHRA7 | AMPA-selective glutamate receptor 2 | GluA2 | GluR-2 | GluR-B | GluR-K2 | GLUR2 | Glutamate receptor ionotropic, AMPA 2 | EAA4 | Excitatory amino acid receptor 4 | GluK2 | GluR-6 | GLUR6 | Glutamate receptor 6 | GluN1 | Glutamate [NMDA] receptor subunit zeta-1 | hNR1 | N-methyl-D-aspartate receptor subunit NR1 | NMD-R1 | NMDAR1 | GluN2A | Glutamate [NMDA] receptor subunit epsilon-1 | hNR2A | N-methyl D-aspartate receptor subtype 2A | NMDAR2A | NR2A | GluN2B | Glutamate [NMDA] receptor subunit epsilon-2 | hNR3 | N-methyl D-aspartate receptor subtype 2B | N-methyl-D-aspartate receptor subunit 3 | NMDAR2B | NR2B | NR3 | GluN2C | Glutamate [NMDA] receptor subunit epsilon-3 | N-methyl D-aspartate receptor subtype 2C | NMDAR2C | NR2C | EB11 | GluN2D | Glutamate [NMDA] receptor subunit epsilon-4 | N-methyl D-aspartate receptor subtype 2D | NMDAR2D | NR2D | GluN3A | KIAA1973 | N-methyl-D-aspartate receptor subtype 3A | NMDAR-L | NMDAR3A | NR3A | GluN3B | N-methyl-D-aspartate receptor subtype 3B | NMDAR3B | NR3B | 1.14.14.1 | Cholesterol 25-hydroxylase | CYPIA2 | Cytochrome P(3)450 | Cytochrome P450 4 | Cytochrome P450-P3 | Hydroperoxy icosatetraenoate dehydratase | (R)-limonene 6-monooxygenase | (S)-limonene 6-monooxygenase | (S)-limonene 7-monooxygenase | 1.14.14.1 | CYPIIC17 | CYPIIC19 | Cytochrome P450-11A | Cytochrome P450-254C | Fenbendazole monooxygenase (4'-hydroxylating) | Mephenytoin 4-hydroxylase | 1.14.14.1 | CYPIIC8 | Cytochrome P450 form 1 | Cytochrome P450 IIC2 | Cytochrome P450 MP-12 | Cytochrome P450 MP-20 | S-mephenytoin 4-hydroxylase | (R)-limonene 6-monooxygenase | (S)-limonene 6-monooxygenase | (S)-limonene 7-monooxygenase | 1.14.14.1 | Cholesterol 25-hydroxylase | CYP2C10 | CYPIIC9 | Cytochrome P-450MP | Cytochrome P450 MP-4 | Cytochrome P450 MP-8 | Cytochrome P450 PB-1 | S-mephenytoin 4-hydroxylase
|
[
"Novo-secobarb 100mg",
"Seconal Sodium",
"Seconal Sodium",
"Seconal Sodium",
"Seconal Sodium Pulvule 240 0.1gm",
"Tuinal Pulvule 303",
"Tuinal Pulvule 304"
] |
[
"Seconal",
"Tuinal"
] |
[
"Tuinal Pulvule 303",
"Tuinal Pulvule 304"
] |
[
"P47869",
"P34903",
"P48169",
"P31644",
"Q16445",
"P14867",
"P43681",
"P36544",
"P42262",
"Q13002",
"Q05586",
"Q12879",
"Q13224",
"Q14957",
"O15399",
"Q8TCU5",
"O60391"
] |
[
"P05177",
"P33261",
"P10632",
"P11712"
] |
[] |
[] |
DB00419
|
Miglustat
|
Miglustat, commonly marketed under the trade name Zavesca, is a drug used to treat Gaucher disease. It inhibits the enzyme glucosylceramide synthase, an essential enzyme for the synthesis of most glycosphingolipids. It is only used for patients who cannot be treated with enzyme replacement therapy with imiglucerase. Miglustat is now the first and only approved therapy for patients with Niemann-Pick disease type C (NP-C). It has recently been approved for treatment of progressive neurological symptoms in adult and pediatric patients in the European Union, Brazil, and South Korea. Miglustat was first developed as an anti-HIV agent in the 1990s. However, clinical experience with miglustat showed that therapeutic levels of the drug could not be achieved in patients without a high incidence of adverse effect.
|
solid
|
For the treatment of adult patients with mild to moderate type 1 (nonneuropathic) Gaucher's disease for whom enzyme replacement therapy is not a therapeutic option (e.g. due to constraints such as allergy, hypersensitivity, or poor venous access). Now approved in some countries for the treatment of progressive neurological symptoms in adult and pediatric patients with Niemann-Pick disease type C (NP-C).
|
Miglustat, an N-alkylated imino sugar, is a synthetic analogue of D-glucose. Miglustat is an inhibitor of the enzyme glucosylceramide synthase, which is a glucosyl transferase enzyme responsible for catalyzing the formation of glucosylceramide (glucocerebroside). Glucosylceramide is a substrate for the endogenous glucocerebrosidase, an enzyme that is deficient in Gaucher's disease. The accumulation of glucosylceramide due to the absence of glucocerebrosidase results in the storage of this material in the lysosomes of tissue macrophages, leading to widespread pathology due to infiltration of lipid-engorged macrophages in the viscera, lymph nodes, and bone marrow. This results in secondary hematologic consequences including sever anemia and thrombocytopenia, in addition to the characteristic progressive hepatosplenomegaly, as well as skeletal complications including osteonecrosis and osteopenia with secondary pathological fractures.
|
Miglustat functions as a competitive and reversible inhibitor of the enzyme glucosylceramide synthase, the initial enzyme in a series of reactions which results in the synthesis of most glycosphingolipids. The goal of treatment with miglustat is to reduce the rate of glycosphingolipid biosynthesis so that the amount of glycosphingolipid substrate is reduced to a level which allows the residual activity of the deficient glucocerebrosidase enzyme to be more effective (substrate reduction therapy), reducing the accumulation of glucocerebroside in macrophages. In vitro and in vivo studies have shown that miglustat can reduce the synthesis of glucosylceramide-based glycosphingolipids. In clinical trials, miglustat improved liver and spleen volume, as well as hemoglobin concentration and platelet count. Inhibition of glycosphingolipid synthesis has also shown to reduce intracellular lipid storage, improve fluid-phase endosomal uptake and normalize lipid transport in peripheral blood B lymphocytes of NP-C patients, which results in a decrease in the potentially neurotoxic accumulation of gnagliosides G<sub>M2</sub> and G<sub>M3</sub>, lactosylceramide and glucosylceramide, possibly preventing further neuronal damage. Other studies have also suggested that miglustat may indirectly modulate intracellular calcium homeostasis through its effects on glucosylceramide levels, and evidence has shown that an initiating factor in the pathogenesis of NP-C may be impaired calcium homeostasis related to sphingosine storage. Therefore, the effect that miglustat exerts on intracellular calcium levels may influence an important underlying pathogenic mechanism of NP-C.
|
Mean oral bioavailability is 97%.
|
There is no evidence that miglustat is metabolized in humans.
|
Miglustat has been administered at doses of up to 3000 mg/day (approximately 10 times the recommended starting dose administered to Gaucher patients) for up to six months in Human Immunodeficiency Virus (HIV)-positive patients. Adverse events observed in the HIV studies included granulocytopenia, dizziness, and paresthesia. Leukopenia and neutropenia have also been observed in a similar group of patients receiving 800 mg/day or above.
|
The effective half-life of miglustat is approximately 6 to 7 hours.
|
Miglustat does not bind to plasma proteins.
| null | null | null |
Organic compounds
|
Organoheterocyclic compounds
|
Piperidines
| null |
[
"approved"
] |
[
"A16AX",
"A16A",
"A16",
"A"
] |
[
"Humans and other mammals"
] |
[
{
"cost": "160.67",
"description": "Zavesca 100 mg capsule",
"unit": "capsule"
}
] |
[
{
"approved": "1996-06-11",
"country": "United States",
"expires": "2013-06-11",
"number": "5525616"
},
{
"approved": "1995-12-05",
"country": "United States",
"expires": "2013-05-13",
"number": "5472969"
},
{
"approved": "2015-09-30",
"country": "United States",
"expires": "2035-09-30",
"number": "11753632"
},
{
"approved": "2016-12-29",
"country": "United States",
"expires": "2036-12-29",
"number": "11278601"
},
{
"approved": "2013-03-07",
"country": "United States",
"expires": "2033-03-07",
"number": "11278599"
},
{
"approved": "2021-03-30",
"country": "United States",
"expires": "2035-09-30",
"number": "10961522"
},
{
"approved": "2020-12-08",
"country": "United States",
"expires": "2037-08-12",
"number": "10857212"
},
{
"approved": "2019-12-24",
"country": "United States",
"expires": "2033-03-07",
"number": "10512677"
},
{
"approved": "2019-02-19",
"country": "United States",
"expires": "2035-09-30",
"number": "10208299"
}
] |
1,5-(butylimino)-1,5-dideoxy, D-glucitol | AT2221 | BuDNJ | Butyldeoxynojirimycin | Miglustat | Miglustatum | N-(n-Butyl)deoxynojirimycin | n-Butyl deoxynojirimycin | N-butyl-1-deoxynojirimycin | N-butyl-deoxynojirimycin | N-Butylmoranoline | NB-DNJ | 2.4.1.80 | GCS | GLCT-1 | Glucosylceramide synthase | Glycosylceramide synthase | UDP-glucose ceramide glucosyltransferase | UDP-glucose:N-acylsphingosine D-glucosyltransferase
|
[
"Miglustat",
"Miglustat",
"Miglustat",
"Miglustat",
"Miglustat",
"Miglustat Dipharma",
"Miglustat Dipharma",
"Miglustat Dipharma",
"Miglustat Gen.orph",
"Miglustat Gen.orph",
"Opfolda",
"Opfolda",
"Opfolda",
"Sandoz Miglustat",
"Yargesa",
"Yargesa",
"Zavesca",
"Zavesca",
"Zavesca"
] |
[
"Zavesca"
] |
[] |
[
"Q16739"
] |
[] |
[] |
[] |
DB00420
|
Promazine
|
A phenothiazine with actions similar to chlorpromazine but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as an antiemetic. It is currently not approved for use in the United States.
|
liquid
|
Used as an adjunct for short term treatment of moderate and severe psychomotor agitation. Also used to treat agitation or restlessness in the elderly.
|
Promazine belongs to a group of medications known as the phenothiazine antipsychotics. It acts by blocking a variety of receptors in the brain, particularly dopamine receptors. Dopamine is involved in transmitting signals between brain cells. When there is an excess amount of dopamine in the brain it causes over-stimulation of dopamine receptors. These receptors normally act to modify behaviour and over-stimulation may result in psychotic illness. Promazine hydrochloride blocks these receptors and stops them becoming over-stimulated, thereby helping to control psychotic illness. Promazine has weak extrapyramidal and autonomic side effects which lead to its use in the elderly, for restless or psychotic patients. Its anti-psychotic effect is also weaker and it is not useful in general psychiatry.
|
Promazine is an antagonist at types 1, 2, and 4 dopamine receptors, 5-HT receptor types 2A and 2C, muscarinic receptors 1 through 5, alpha(1)-receptors, and histamine H1-receptors. Promazine's antipsychotic effect is due to antagonism at dopamine and serotonin type 2 receptors, with greater activity at serotonin 5-HT2 receptors than at dopamine type-2 receptors. This may explain the lack of extrapyramidal effects. Promazine does not appear to block dopamine within the tubero-infundibular tract, explaining the lower incidence of hyperprolactinemia than with typical antipsychotic agents or risperidone. Antagonism at muscarinic receptors, H1-receptors, and alpha(1)-receptors also occurs with promazine.
|
Absorption may be erratic and peak plasma concentrations show large interindividual differences.
|
Hepatic, primarily to N-desmethylpromazine and promazine sulfoxide.
|
Side effects include: extrapyramidal symptoms, drowsiness, weight gain, dry mouth, constipation, endocrine effects (such as gynaecomastia and menstrual disturbance), sensitivity to sunlight and haemolytic anaemia.
| null |
94%
| null | null | null |
Organic compounds
|
Organoheterocyclic compounds
|
Benzothiazines
|
Phenothiazines
|
[
"approved",
"vet_approved"
] |
[
"N05AA",
"N05A",
"N05",
"N"
] |
[
"Humans and other mammals"
] |
[
{
"cost": "1.05",
"description": "Chlorpromazine 200 mg tablet",
"unit": "tablet"
},
{
"cost": "8.04",
"description": "Chlorpromazine 25 mg/ml amp",
"unit": "ml"
},
{
"cost": "0.17",
"description": "Chlorpromazine 25 mg tablet",
"unit": "tablet"
},
{
"cost": "0.18",
"description": "Novo-Chlorpromazine 25 mg Tablet",
"unit": "tablet"
},
{
"cost": "0.21",
"description": "Novo-Chlorpromazine 50 mg Tablet",
"unit": "tablet"
},
{
"cost": "0.3",
"description": "Chlorpromazine 50 mg tablet",
"unit": "tablet"
},
{
"cost": "0.32",
"description": "Chlorpromazine 10 mg tablet",
"unit": "tablet"
},
{
"cost": "0.35",
"description": "Novo-Chlorpromazine 100 mg Tablet",
"unit": "tablet"
},
{
"cost": "0.39",
"description": "Chlorpromazine 100 mg tablet",
"unit": "tablet"
},
{
"cost": "0.88",
"description": "Chlorpromazine Hcl 25 mg/ml",
"unit": "ml"
}
] |
[] |
10-(3-(Dimethylamino)propyl)phenothiazine | N-(3-Dimethylaminopropyl)phenothiazine | N-Dimethylamino-1-methylethyl thiodiphenylamine | N,N-dimethyl-3-(10H-phenothiazin-10-yl)-propan-1-amine | Promazin | Promazina | Promazine | Promazinum | Dopamine D2 receptor | 5-HT-2 | 5-HT-2A | HTR2 | Serotonin receptor 2A | 5-HT-1C | 5-HT-2C | 5-HT1C | 5-HT2C | 5-HTR2C | 5-hydroxytryptamine receptor 1C | HTR1C | Serotonin receptor 2C | ADRA1C | Alpha-1A adrenoceptor | Alpha-1A adrenoreceptor | Alpha-1C adrenergic receptor | Alpha-adrenergic receptor 1c | H1-R | H1R | HH1R | 1.14.14.1 | Cholesterol 25-hydroxylase | CYPIA2 | Cytochrome P(3)450 | Cytochrome P450 4 | Cytochrome P450-P3 | Hydroperoxy icosatetraenoate dehydratase | 1,4-cineole 2-exo-monooxygenase | 1,8-cineole 2-exo-monooxygenase | 1.14.14.1 | Albendazole monooxygenase (sulfoxide-forming) | Albendazole sulfoxidase | Cholesterol 25-hydroxylase | CYP3A3 | CYPIIIA3 | CYPIIIA4 | Cytochrome P450 3A3 | Cytochrome P450 HLp | Cytochrome P450 NF-25 | Cytochrome P450-PCN1 | Nifedipine oxidase | Quinine 3-monooxygenase | (R)-limonene 6-monooxygenase | (S)-limonene 6-monooxygenase | (S)-limonene 7-monooxygenase | 1.14.14.1 | Cholesterol 25-hydroxylase | CYP2C10 | CYPIIC9 | Cytochrome P-450MP | Cytochrome P450 MP-4 | Cytochrome P450 MP-8 | Cytochrome P450 PB-1 | S-mephenytoin 4-hydroxylase | 1.14.14.- | Cholesterol 25-hydroxylase | CYP2DL1 | CYPIID6 | Cytochrome P450-DB1 | Debrisoquine 4-hydroxylase | (R)-limonene 6-monooxygenase | (S)-limonene 6-monooxygenase | (S)-limonene 7-monooxygenase | 1.14.14.1 | CYPIIC17 | CYPIIC19 | Cytochrome P450-11A | Cytochrome P450-254C | Fenbendazole monooxygenase (4'-hydroxylating) | Mephenytoin 4-hydroxylase
|
[
"Promazine HCl Inj 50mg/ml"
] |
[
"Combelen",
"Prazine",
"Sparine",
"Talofen"
] |
[] |
[
"P14416",
"P08912",
"P28223",
"P28335",
"P35348",
"P11229",
"P35367"
] |
[
"P05177",
"P08684",
"P11712",
"P10635",
"P33261"
] |
[] |
[] |
DB00422
|
Methylphenidate
|
Methylphenidate is a central nervous system stimulant used most commonly in the treatment of Attention-Deficit/Hyperactivity Disorder (ADHD) and for narcolepsy. Also known as the marketed products Ritalin, Concerta, or Biphentin, methylphenidate is used with other treatment modalities (psychological, educational, cognitive behaviour therapy, etc) to improve the following group of developmentally inappropriate symptoms associated with ADHD: moderate-to-severe distractibility, short attention span, hyperactivity, emotional lability, and impulsivity. Long-acting formulations of psychostimulants such as methylphenidate, [DB01576], and [DB01255] are considered the most effective and widely used treatment for ADHD, and are considered first-line options for children, adolescents, and adults as recommended by CADDRA (Canadian ADHD Resource Alliance). [L6037] CADDRA recommends the use of methylphenidate due to long term studies, of over twenty years in duration, which show methylphenidate is safe and effective.
While its exact mechanism is unclear, methylphenidate (MPH) has been shown to act as a norepinephrine and dopamine reuptake inhibitor (NDRI), thereby increasing the presence of these neurotransmitters in the extraneuronal space and prolonging their action.[A177541] There is a dose-related effect of psychostimulants on receptor stimulation, where higher doses are shown to increase norepinephrine (NE) and dopamine (DA) efflux throughout the brain which can result in impaired cognition and locomotor-activating effects. In contrast, low doses are found to selectively activate NE and DA neurotransmission within the prefrontal cortex which is an area of the brain thought to play a prominent role in ADHD pathophysiology, thereby improving clinical efficacy and preventing side effects.[A177547] The lower doses used to treat ADHD are not associated with the locomotor-activating effects associated with higher doses and instead reduce movement, impulsivity, and increase cognitive function including sustained attention and working memory.[A177541, A177544] Methylphenidate's beneficial effects in sustaining attention have also been shown to be mediated by alpha-1 adrenergic receptor activity.[A177550] Clinical findings have shown that children with ADHD have an abnormality in the dopamine transporter gene (DAT1), the D4 receptor gene (DRD-4), and/or the D2 receptor gene that may be at least partly overcome by the dopaminergic effects of methylphenidate, suggesting a possible mode of action.[F4474]
When provided as Biphentin®, methylphenidate is released through a multi-layer release delivery system (MLRTM) where 40% of the dose is provided as an immediate release and 60% is provided through a gradual release. Biphentin was designed to be an alternative to separate doses of immediate-release (IR) methylphenidate by providing a biphasic concentration-time profile when given as a single dose. The MLRTM release system allows for a sustained effect for 10-12 hours, allowing for once-daily dosing that covers the major times that ADHD impairment might occur (such as school, homework periods, during the work day, etc).
When provided as Concerta®, methylphenidate is released through the patented Osmotic Controlled-Release Oral Delivery (OROS) system where 22% of the dose is provided as an immediate release and 78% is provided through a gradual release.[A631] OROS is comprised of an osmotically active trilayer core surrounded by a semipermeable membrane with an immediate-release drug overcoat. Within an aqueous environment, such as the stomach, the drug overcoat, which consists of 22% of the dose, dissolves within one hour, providing an initial immediate-release formulation of methylphenidate. Water then permeates through the membrane into the tablet core where the osmotically active polymer excipients expand, allowing methylphenidate to release slowly through the orifice over a period of 6-7 hours. Concerta also provides a sustained 10-12 hour effect, allowing for once-daily dosing.
Methylphenidate contains a blackbox warning stating that CNS stimulants, including methylphenidate-containing products and amphetamines, have a high potential for abuse and dependence. This abuse potential is likely related to the effects associated with higher doses of methylphenidate, which induce surface expression of the dopamine transporter (DAT).[A177553] In particular, increased dopamine in key brain areas is associated with the reinforcing and addictive properties of psychostimulants such as methylphenidate, and even amplifies the potency and reinforcing effects of other drugs of abuse such as amphetamines, making ADHD sufferers more susceptible to their addictive effects.[A177556] Concerns about abuse potential have spurred research into medications with fewer effects on DAT and the use of non-stimulant ADHD medications including [DB00289] and [DB01018].
|
solid
|
Methylphenidate is indicated for the treatment of Attention Deficit Hyperactivity Disorder (ADHD) in patients 6 years of age and older and for the treatment of narcolepsy.
|
Methylphenidate is a racemic mixture comprised of the d- and l-isomers. The d-isomer is more pharmacologically active than the l-isomer. Radioligand binding studies demonstrate that binding of methylphenidate in the brain is localized to dopamine-rich areas, in particular in the prefrontal cortex which has been demonstrated to play a prominent role in ADHD pathophysiology.[A177547] In a number of animal models, methylphenidate enhances locomotor activity and induces stereotypic behaviours.
|
While its exact mechanism is unclear, methylphenidate (MPH) has been shown to act as a norepinephrine and dopamine reuptake inhibitor (NDRI), thereby increasing the presence of these neurotransmitters in the extraneuronal space and prolonging their action.[A177541] There is a dose-related effect of psychostimulants on receptor stimulation, where higher doses are shown to increase norepinephrine (NE) and dopamine (DA) efflux throughout the brain which can result in impaired cognition and locomotor-activating effects. In contrast, low doses are found to selectively activate NE and DE neurotransmission within the prefrontal cortex which is an area of the brain thought to play a prominent role in ADHD pathophysiology, thereby improving clinical efficacy and preventing side effects.[A177547] The lower doses used to treat ADHD are not associated with the locomotor-activating effects associated with higher doses and instead reduce movement, impulsivity, and increase cognitive function including sustained attention and working memory.[A177541, A177544] Methylphenidate's beneficial effects in sustaining attention have also been shown to be mediated by alpha-1 adrenergic receptor activity.[A177550]
Clinical findings have shown that children with ADHD have an abnormality in the dopamine transporter gene (DAT1), the D4 receptor gene (DRD-4), and/or the D2 receptor gene that may be at least partly overcome by the dopaminergic effects of methylphenidate, suggesting a possible mode of action.[F4474]
|
Concerta®: Methylphenidate is readily absorbed. Following oral administration of Concerta, plasma methylhphenidate concentrations reach an initial maximum at about 1 hour followed by gradual ascending concentrations over the next 5-9 hours. Mean times to reach peak plasma concentrations across all doses of Concerta occurred between 6-10 hours. Once daily dosing minimizes the fluctuations between peak and trough concentrations associated with multiple doses of immediate-release methylphenidate treatments.[F4474] Depending on the doses provided, Cmax was found to range from 6.0-15.0ng/mL, Tmax ranged from 8.1-9.4h, and AUC ranged from 50.4-121.5 ng·h/mL in children.[F4474]
When provided as Concerta®, methylphenidate is released through the patented Osmotic Controlled-Release Oral Delivery (OROS) system where 22% of the dose is provided as an immediate release and 78% is provided through a gradual release.[A631] OROS is comprised of an osmotically active trilayer core surrounded by a semipermeable membrane with an immediate-release drug overcoat. Within an aqueous environment, such as the stomach, the drug overcoat, which consists of 22% of the dose, dissolves within one hour, providing an initial immediate-release formulation of methylphenidate. Water then permeates through the membrane into the tablet core where the osmotically active polymer excipients expand, allowing methylphenidate to release slowly through the orifice over a period of 6-7 hours. Concerta also provides a sustained 10-12 hour effect, allowing for once-daily dosing.
Biphentin®: Methylphenidate is rapidly and extensively absorbed following oral administration, with peak blood levels obtained in 1-3 hours.[F4480]
When provided as Biphentin®, methylphenidate is released through a multi-layer release delivery system (MLRTM) where 40% of the dose is provided as an immediate release and 60% is provided through a gradual release. Biphentin was designed to be an alternative to separate doses of immediate-release (IR) methylphenidate by providing a biphasic concentration-time profile when given as a single dose. The MLRTM release system allows for a sustained effect for 10-12 hours, allowing for once-daily dosing that covers the major times that ADHD impairment might occur (such as school, homework periods, during the workday, etc).
Methylphenidate (immediate release): Methylphenidate hydrochloride is rapidly and extensively absorbed from the tablets following oral administration; however, owing to extensive first-pass metabolism, bioavailability is low (approx. 30%) and large individual differences exist (11-52%). In one study, the administration of methylphenidate hydrochloride with food accelerated absorption but had no effect on the amount absorbed. Peak plasma concentrations of 10.8 and 7.8 ng/mL were observed, on average, 2 hours after administration of 0.30 mg/kg in children and adults, respectively. Peak plasma concentrations showed marked variability between subjects. Both the area under the concentration-time curve (AUC), and the peak plasma concentrations (Cmax) showed dose-proportionality.[F4483]
|
Methylphenidate is hepatically metabolized. More specifically, it is rapidly and extensively metabolized by carboxylesterase CES1A1. Via this enzyme, methylphenidate undergoes de-esterification to ritalinic acid (a-phenyl-2-piperidine acetic acid, PPAA), which has little to no pharmacologic activity.
|
Symptoms of overdose include vomiting, agitation, tremors, hyperreflexia, muscle twitching, convulsions (may be followed by coma), euphoria, confusion, hallucinations, delirium, sweating, flushing, headache, hyperpyrexia, tachycardia, palpitations, cardiac arrhythmias, hypertension, mydriasis, and dryness of mucous membranes. LD<sub>50</sub>=190mg/kg (orally in mice)
|
Concerta: The half-life of methylphenidate in adults following oral administration of Concerta® was approximately 3.5 h.[F4474]
Biphentin: Methylphenidate is eliminated from plasma with a mean half-life of 2.4 hours in children and 2.1 hours in adults.[F4480]
Methylphenidate (immediate release): Methylphenidate is eliminated from the plasma with a mean half-life of 2.4 hours in children and 2.1 hours in adults.[F4483]
|
Concerta: In humans, 15 ± 5% of methylphenidate in the blood is bound to plasma proteins. [F4474]
Biphentin: In blood, methylphenidate and its metabolites are distributed between plasma (57%) and
erythrocytes (43%). Methylphenidate and its metabolites exhibit low plasma protein binding
(approximately 15%).[F4480]
Methylphenidate (immediate release): In blood, methylphenidate and its metabolites are distributed between plasma (57%) and erythrocytes (43%). Methylphenidate and its metabolites exhibit low plasma protein binding (approx. 15%).[F4483]
|
After oral administration of an immediate release formulation of methylphenidate, 78%-97% of the dose is excreted in the urine and 1%-3% in the feces in the form of metabolites within 48-96 hours. Only small quantities (<1%) of unchanged methylphenidate appear in the urine. Most of the dose is excreted in the urine as ritalinic acid (60%-86%), the remainder being accounted for by minor metabolites.
|
Concerta: Plasma methylphenidate concentrations in adults decline bi-exponentially
following oral administration.[F4474]
Biphentin: The apparent distribution volume of methylphenidate in children is approximately 20 L/kg, with
substantial variability (11 to 33 L/kg).[F4480]
Methylphenidate (immediate release): The apparent distribution volume of methylphenidate in children was approximately 20 L/kg, with substantial variability (11-33 L/kg). The volume of distribution after an intravenous dose (Vss) is 2.23 L/kg for the racemate in healthy adult volunteers.[F4483]
|
The apparent mean systemic clearance after an oral dose is 10.2 and 10.5 L/h/kg in children and adults, respectively for a 0.3 mg/kg dose, and 0.565 L/h/kg after an intravenous dose of the racemate in healthy adult volunteers.[F4483]
|
Organic compounds
|
Organic nitrogen compounds
|
Organonitrogen compounds
|
Amines
|
[
"approved",
"investigational"
] |
[
"N06BA",
"N06B",
"N06",
"N"
] |
[
"Humans and other mammals"
] |
[
{
"cost": "1.0",
"description": "Methylin ER 10 mg",
"unit": "tab"
},
{
"cost": "1.05",
"description": "Methylphenidate HCl 20 mg tablet",
"unit": "tablet"
},
{
"cost": "1.12",
"description": "Methylin er 20 mg tablet",
"unit": "tablet"
},
{
"cost": "1.2",
"description": "Methylphenidate HCl CR 20 mg Controlled Release Tabs",
"unit": "tab"
},
{
"cost": "1.26",
"description": "Focalin 5 mg tablet",
"unit": "tablet"
},
{
"cost": "1.28",
"description": "Metadate er 10 mg tablet sa",
"unit": "tablet"
},
{
"cost": "1.29",
"description": "Ritalin 10 mg tablet",
"unit": "tablet"
},
{
"cost": "1.3",
"description": "Methylin ER 20 mg Controlled Release Tabs",
"unit": "tab"
},
{
"cost": "1.32",
"description": "Metadate er 20 mg tablet",
"unit": "tablet"
},
{
"cost": "1.42",
"description": "Ritalin 5 mg tablet",
"unit": "tablet"
},
{
"cost": "1.7",
"description": "Focalin 10 mg tablet",
"unit": "tablet"
},
{
"cost": "1.87",
"description": "Ritalin 20 mg tablet",
"unit": "tablet"
},
{
"cost": "2.67",
"description": "Ritalin sr 20 mg tablet",
"unit": "tablet"
},
{
"cost": "3.0",
"description": "Ritalin SR 20 mg Controlled Release Tabs",
"unit": "tab"
},
{
"cost": "3.24",
"description": "Methylphenidate er 10 mg tablet",
"unit": "tablet"
},
{
"cost": "4.2",
"description": "Metadate cd 10 mg capsule",
"unit": "capsule"
},
{
"cost": "4.24",
"description": "Metadate cd 20 mg capsule",
"unit": "capsule"
},
{
"cost": "4.24",
"description": "Metadate cd 30 mg capsule",
"unit": "capsule"
},
{
"cost": "4.27",
"description": "Concerta 18 mg tablet sa",
"unit": "tablet"
},
{
"cost": "4.33",
"description": "Ritalin la 10 mg capsule",
"unit": "capsule"
},
{
"cost": "4.33",
"description": "Ritalin la 20 mg capsule",
"unit": "capsule"
},
{
"cost": "4.37",
"description": "Concerta 27 mg tablet sa",
"unit": "tablet"
},
{
"cost": "4.42",
"description": "Ritalin LA 10 mg 24 Hour Capsule",
"unit": "capsule"
},
{
"cost": "4.42",
"description": "Ritalin LA 20 mg 24 Hour Capsule",
"unit": "capsule"
},
{
"cost": "4.42",
"description": "Ritalin LA 30 mg 24 Hour Capsule",
"unit": "capsule"
},
{
"cost": "4.42",
"description": "Ritalin LA 40 mg 24 Hour Capsule",
"unit": "capsule"
},
{
"cost": "4.43",
"description": "Ritalin la 30 mg capsule",
"unit": "capsule"
},
{
"cost": "4.51",
"description": "Concerta 36 mg tablet sa",
"unit": "tablet"
},
{
"cost": "4.55",
"description": "Ritalin la 40 mg capsule",
"unit": "capsule"
},
{
"cost": "4.83",
"description": "Focalin XR 5 mg 24 Hour Capsule",
"unit": "capsule"
},
{
"cost": "4.89",
"description": "Focalin XR 15 mg 24 Hour Capsule",
"unit": "capsule"
},
{
"cost": "4.91",
"description": "Concerta 54 mg tablet sa",
"unit": "tablet"
},
{
"cost": "4.95",
"description": "Focalin xr 5 mg capsule",
"unit": "capsule"
},
{
"cost": "4.96",
"description": "Focalin XR 10 mg 24 Hour Capsule",
"unit": "capsule"
},
{
"cost": "5.0",
"description": "Concerta 18 mg Controlled Release Tabs",
"unit": "tab"
},
{
"cost": "5.0",
"description": "Concerta 27 mg Controlled Release Tabs",
"unit": "tab"
},
{
"cost": "5.02",
"description": "Focalin xr 10 mg capsule",
"unit": "capsule"
},
{
"cost": "5.15",
"description": "Focalin XR 30 mg 24 Hour Capsule",
"unit": "capsule"
},
{
"cost": "5.16",
"description": "Daytrana 10 mg/9 hr patch",
"unit": "patch"
},
{
"cost": "5.16",
"description": "Daytrana 15 mg/9 hr patch",
"unit": "patch"
},
{
"cost": "5.16",
"description": "Daytrana 20 mg/9 hour patch",
"unit": "patch"
},
{
"cost": "5.16",
"description": "Daytrana 30 mg/9 hour patch",
"unit": "patch"
},
{
"cost": "5.16",
"description": "Focalin xr 15 mg capsule",
"unit": "capsule"
},
{
"cost": "5.16",
"description": "Focalin xr 20 mg capsule",
"unit": "capsule"
},
{
"cost": "5.31",
"description": "Focalin XR 20 mg 24 Hour Capsule",
"unit": "capsule"
},
{
"cost": "5.42",
"description": "Focalin xr 30 mg capsule",
"unit": "capsule"
},
{
"cost": "5.72",
"description": "Concerta 36 mg Controlled Release Tabs",
"unit": "tab"
},
{
"cost": "5.77",
"description": "Metadate cd 40 mg capsule",
"unit": "capsule"
},
{
"cost": "6.18",
"description": "Concerta 54 mg Controlled Release Tabs",
"unit": "tab"
},
{
"cost": "7.02",
"description": "Metadate cd 60 mg capsule",
"unit": "capsule"
},
{
"cost": "7.08",
"description": "Metadate cd 50 mg capsule",
"unit": "capsule"
},
{
"cost": "22.11",
"description": "Concerta er 18 mg tablet",
"unit": "tablet"
},
{
"cost": "22.65",
"description": "Concerta er 27 mg tablet",
"unit": "tablet"
},
{
"cost": "23.38",
"description": "Concerta er 36 mg tablet",
"unit": "tablet"
},
{
"cost": "25.45",
"description": "Concerta er 54 mg tablet",
"unit": "tablet"
},
{
"cost": "44.62",
"description": "Methylphenidate hcl powder",
"unit": "g"
},
{
"cost": "168.72",
"description": "Daytrana 30 20 mg/9hr Patches Box",
"unit": "box"
},
{
"cost": "172.78",
"description": "Daytrana 30 10 mg/9hr Patches Box",
"unit": "box"
},
{
"cost": "174.73",
"description": "Daytrana 30 30 mg/9hr Patches Box",
"unit": "box"
},
{
"cost": "175.64",
"description": "Daytrana 30 15 mg/9hr Patches Box",
"unit": "box"
},
{
"cost": "0.1",
"description": "Pms-Methylphenidate 5 mg Tablet",
"unit": "tablet"
},
{
"cost": "0.17",
"description": "Apo-Methylphenidate 10 mg Tablet",
"unit": "tablet"
},
{
"cost": "0.17",
"description": "Pms-Methylphenidate 10 mg Tablet",
"unit": "tablet"
},
{
"cost": "0.33",
"description": "Methylin 5 mg tablet",
"unit": "tablet"
},
{
"cost": "0.33",
"description": "Methylphenidate 5 mg tablet",
"unit": "tablet"
},
{
"cost": "0.37",
"description": "Apo-Methylphenidate 20 mg Tablet",
"unit": "tablet"
},
{
"cost": "0.37",
"description": "Apo-Methylphenidate Sr 20 mg Extended-Release Tablet",
"unit": "tablet"
},
{
"cost": "0.37",
"description": "Pms-Methylphenidate 20 mg Tablet",
"unit": "tablet"
},
{
"cost": "0.37",
"description": "Sandoz Methylphenidate 20 mg Extended-Release Tablet",
"unit": "tablet"
},
{
"cost": "0.38",
"description": "Ritalin 10 mg Tablet",
"unit": "tablet"
},
{
"cost": "0.48",
"description": "Methylin 10 mg tablet",
"unit": "tablet"
},
{
"cost": "0.48",
"description": "Methylphenidate 10 mg tablet",
"unit": "tablet"
},
{
"cost": "0.67",
"description": "Ritalin 20 mg Tablet",
"unit": "tablet"
},
{
"cost": "0.67",
"description": "Ritalin Sr 20 mg Extended-Release Tablet",
"unit": "tablet"
},
{
"cost": "0.69",
"description": "Methylin 20 mg tablet",
"unit": "tablet"
},
{
"cost": "0.69",
"description": "Methylphenidate 20 mg tablet",
"unit": "tablet"
},
{
"cost": "0.76",
"description": "Focalin 2.5 mg tablet",
"unit": "tablet"
},
{
"cost": "0.84",
"description": "Methylin er 10 mg tablet",
"unit": "tablet"
},
{
"cost": "0.94",
"description": "Methylphenidate HCl 5 mg tablet",
"unit": "tablet"
},
{
"cost": "0.95",
"description": "Methylphenidate HCl 10 mg tablet",
"unit": "tablet"
}
] |
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] |
Methyl phenidylacetate | methyl phenyl(piperidin-2-yl)acetate | methyl α-phenyl-α-(2-piperidyl)acetate | methyl α-phenyl-α-2-piperidinylacetate | Methylphenidan | Methylphenidate | Methylphenidatum | Metilfenidato | MPH | α-phenyl-2-piperidineacetic acid methyl ester | DA transporter | DAT | DAT1 | Solute carrier family 6 member 3 | 5-HT-1A | 5-HT1A | ADRB2RL1 | ADRBRL1 | G-21 | Serotonin receptor 1A | NAT1 | NET | NET1 | Norepinephrine transporter | SLC6A5 | Solute carrier family 6 member 2 | Carboxylesterase 1A1 | CES1A1
|
[
"Act Methylphenidate ER",
"Act Methylphenidate ER",
"Act Methylphenidate ER",
"Act Methylphenidate ER",
"Adhansia XR",
"Adhansia XR",
"Adhansia XR",
"Adhansia XR",
"Adhansia XR",
"Adhansia XR",
"Apo-methylphenidate",
"Apo-methylphenidate",
"Apo-methylphenidate",
"Apo-methylphenidate ER",
"Apo-methylphenidate ER",
"Apo-methylphenidate ER",
"Apo-methylphenidate ER",
"Apo-methylphenidate SR",
"Aptensio XR",
"Aptensio XR",
"Aptensio XR",
"Aptensio XR",
"Aptensio XR",
"Aptensio XR",
"Aptensio XR",
"Bar-methylphenidate HCl CR",
"Bar-methylphenidate HCl CR",
"Bar-methylphenidate HCl CR",
"Bar-methylphenidate HCl CR",
"Bar-methylphenidate HCl CR",
"Bar-methylphenidate HCl CR",
"Bar-methylphenidate HCl CR",
"Bar-methylphenidate HCl CR",
"Biphentin",
"Biphentin",
"Biphentin",
"Biphentin",
"Biphentin",
"Biphentin",
"Biphentin",
"Biphentin",
"Concerta",
"Concerta",
"Concerta",
"Concerta",
"Concerta",
"Concerta",
"Concerta",
"Concerta",
"Concerta",
"Concerta",
"Concerta",
"Concerta",
"Concerta",
"Concerta",
"Concerta",
"Concerta",
"Concerta",
"Concerta",
"Cotempla XR-ODT",
"Cotempla XR-ODT",
"Cotempla XR-ODT",
"Daytrana",
"Daytrana",
"Daytrana",
"Daytrana",
"Daytrana",
"Daytrana",
"Daytrana",
"Daytrana",
"Foquest",
"Foquest",
"Foquest",
"Foquest",
"Foquest",
"Foquest",
"Foquest",
"Jornay PM",
"Jornay PM",
"Jornay PM",
"Jornay PM",
"Jornay PM",
"JORNAY PM Extended-Release",
"JORNAY PM Extended-Release",
"JORNAY PM Extended-Release",
"JORNAY PM Extended-Release",
"JORNAY PM Extended-Release",
"Metadate",
"Metadate CD",
"Metadate CD",
"Metadate CD",
"Metadate CD",
"Metadate CD",
"Metadate CD",
"Metadate CD",
"Metadate CD",
"Metadate CD",
"Metadate CD",
"Metadate CD",
"Metadate CD",
"Metadate CD",
"Metadate CD",
"Metadate CD",
"Metadate CD",
"Metadate CD",
"Metadate CD",
"Metadate CD",
"Metadate CD",
"Metadate ER",
"Metadate ER",
"Metadate ER",
"Methylin",
"Methylin",
"Methylin",
"Methylin",
"Methylin",
"Methylin",
"Methylin",
"Methylin",
"Methylin",
"Methylin",
"Methylin",
"Methylin",
"Methylin",
"Methylin",
"Methylin",
"Methylin",
"Methylin",
"Methylin ER",
"Methylin ER",
"Methylin ER",
"Methylin ER",
"Methylin ER",
"Methylphenidate",
"Methylphenidate",
"Methylphenidate",
"Methylphenidate",
"Methylphenidate",
"Methylphenidate",
"Methylphenidate",
"Methylphenidate",
"Methylphenidate",
"Methylphenidate",
"Methylphenidate",
"Methylphenidate",
"Methylphenidate",
"Methylphenidate",
"Methylphenidate",
"Methylphenidate",
"Methylphenidate",
"Methylphenidate HCl",
"Methylphenidate HCl",
"Methylphenidate HCl",
"Methylphenidate HCl",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate hydrochloride",
"Methylphenidate hydrochloride",
"Methylphenidate hydrochloride",
"Methylphenidate hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"methylphenidate Hydrochloride",
"methylphenidate Hydrochloride",
"methylphenidate Hydrochloride",
"methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate hydrochloride",
"Methylphenidate hydrochloride",
"Methylphenidate hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride",
"Methylphenidate Hydrochloride (CD)",
"Methylphenidate Hydrochloride (CD)",
"Methylphenidate Hydrochloride (CD)",
"Methylphenidate Hydrochloride (CD)",
"Methylphenidate Hydrochloride (CD)",
"Methylphenidate Hydrochloride (CD)",
"Methylphenidate Hydrochloride (CD)",
"Methylphenidate Hydrochloride (CD)",
"Methylphenidate Hydrochloride (LA)",
"Methylphenidate Hydrochloride (LA)",
"Methylphenidate Hydrochloride (LA)",
"Methylphenidate Hydrochloride (LA)",
"Methylphenidate Hydrochloride (LA)",
"Methylphenidate Hydrochloride (LA)",
"Methylphenidate Hydrochloride (LA)",
"Methylphenidate Hydrochloride (LA)",
"Methylphenidate Hydrochloride (LA)",
"Methylphenidate Hydrochloride (LA)",
"Methylphenidate Hydrochloride (LA)",
"Methylphenidate Hydrochloride (LA)",
"Methylphenidate Hydrochloride (LA)",
"Methylphenidate Hydrochloride (LA)",
"Methylphenidate Hydrochloride (LA)",
"Methylphenidate Hydrochloride (LA)",
"Methylphenidate Hydrochloride (LA)",
"Methylphenidate Hydrochloride (LA)",
"Methylphenidate Hydrochloride (LA)",
"Methylphenidate Hydrochloride (LA)",
"Methylphenidate Hydrochloride (LA)",
"methylphenidate hydrochloride CD",
"methylphenidate hydrochloride CD",
"methylphenidate hydrochloride CD",
"methylphenidate hydrochloride CD",
"methylphenidate hydrochloride CD",
"methylphenidate hydrochloride CD",
"methylphenidate hydrochloride CD",
"methylphenidate hydrochloride CD",
"methylphenidate hydrochloride CD",
"methylphenidate hydrochloride CD",
"methylphenidate hydrochloride CD",
"methylphenidate hydrochloride CD",
"Methylphenidate Hydrochloride ER",
"Methylphenidate Hydrochloride ER",
"Methylphenidate Hydrochloride Extended Release",
"Methylphenidate Hydrochloride Extended Release",
"Methylphenidate Hydrochloride Extended-Release",
"Methylphenidate Hydrochloride Extended-Release",
"Methylphenidate Hydrochloride Extended-Release",
"Methylphenidate Hydrochloride Extended-Release",
"Methylphenidate Hydrochloride Extended-Release",
"Methylphenidate Hydrochloride Extended-Release",
"Methylphenidate Hydrochloride Extended-Release",
"Methylphenidate Hydrochloride Extended-Release",
"Methylphenidate Hydrochloride Extended-Release",
"Methylphenidate Hydrochloride SR",
"Methylphenidate Tab 10mg",
"Methylphenidate Tab 20mg",
"Methylphenidate Transdermal System",
"Methylphenidate Transdermal System",
"Methylphenidate Transdermal System",
"Methylphenidate Transdermal System",
"Novo-methylphenidate",
"Novo-methylphenidate",
"Novo-methylphenidate",
"Ntp-methylphenidate ER-C",
"Ntp-methylphenidate ER-C",
"Ntp-methylphenidate ER-C",
"Ntp-methylphenidate ER-C",
"PHL-methylphenidate",
"PHL-methylphenidate",
"PHL-methylphenidate",
"PMS-methylphenidate",
"PMS-methylphenidate",
"PMS-methylphenidate",
"PMS-methylphenidate CR",
"PMS-methylphenidate CR",
"PMS-methylphenidate CR",
"PMS-methylphenidate CR",
"PMS-methylphenidate CR",
"PMS-methylphenidate CR",
"PMS-methylphenidate CR",
"PMS-methylphenidate CR",
"PMS-methylphenidate ER",
"PMS-methylphenidate ER",
"PMS-methylphenidate ER",
"PMS-methylphenidate ER",
"QuilliChew ER",
"QuilliChew ER",
"QuilliChew ER",
"QuilliChew ER",
"QuilliChew ER",
"QuilliChew ER",
"Quillivant ER Chewable Tablets",
"Quillivant ER Chewable Tablets",
"Quillivant ER Chewable Tablets",
"Quillivant ER Oral Suspension",
"Quillivant XR",
"Quillivant XR",
"Quillivant XR",
"Quillivant XR",
"Quillivant XR",
"Quillivant XR",
"Quillivant XR",
"Quillivant XR",
"Ratio-methylphenidate",
"Ratio-methylphenidate",
"Ratio-methylphenidate",
"Relexxii",
"Relexxii",
"Relexxii",
"Relexxii",
"Relexxii",
"Relexxii",
"Relexxii",
"Relexxii",
"Ritalin",
"Ritalin",
"Ritalin",
"Ritalin",
"Ritalin",
"Ritalin",
"Ritalin",
"Ritalin",
"Ritalin",
"Ritalin",
"Ritalin",
"Ritalin 10mg",
"Ritalin 20mg",
"Ritalin LA",
"Ritalin LA",
"Ritalin LA",
"Ritalin LA",
"Ritalin LA",
"Ritalin LA",
"Ritalin LA",
"Ritalin LA",
"Ritalin LA",
"Ritalin LA",
"Ritalin LA",
"Ritalin SR",
"Ritalin-SR",
"Ritalin-SR",
"Ritalin-SR Tab 20mg",
"Sandoz Methylphenidate",
"Sandoz Methylphenidate",
"Sandoz Methylphenidate SR",
"Taro-methylphenidate ER",
"Taro-methylphenidate ER",
"Taro-methylphenidate ER",
"Taro-methylphenidate ER",
"Teva-methylphenidate ER-C",
"Teva-methylphenidate ER-C",
"Teva-methylphenidate ER-C",
"Teva-methylphenidate ER-C"
] |
[
"Equasym XL",
"Medikinet XL",
"Quillivant",
"Riphenidate",
"Rubifen SR"
] |
[] |
[
"Q01959",
"P08908",
"P23975"
] |
[
"Q6LAP9"
] |
[] |
[] |
DB00423
|
Methocarbamol
|
Methocarbamol was developed in the early 1950s as a treatment for muscle spasticity and the associated pain.[A178441,A178450] It is a guaiacol glyceryl ether.[A178450]
Methocarbamol tablets and intramuscular injections are prescription medicines indicated in the United States as an adjunct to rest, physical therapy, and other measures for the relief of discomforts associated with acute, painful musculoskeletal conditions.[Label,L6268] In Canada, methocarbamol can be sold as an over the counter oral medicine at a lower dose that may be combined with [acetaminophen] or [ibuprofen].[L6295] A combination product with [acetylsalicylic acid] and [codeine] is available in Canada by prescription.[L6295]
Methocarbamol was FDA approved on 16 July 1957.[L6265]
|
solid
|
Methocarbamol tablets and intramuscular injections are indicated in the United States as an adjunct to rest, physical therapy, and other measures for the relief of discomforts associated with acute, painful musculoskeletal conditions.[Label,L6268] Oral methocarbamol in America may be given up to 1500mg 4 times daily for 2-3 days.[A31312]
In Canada, methocarbamol containing oral formulations are sold over the counter for pain associated with muscle spasm.[L6295] However, if these combination formulations include codeine, they are prescription only.[L6295]
|
Methacarbamol is a skeletal muscle relaxant with an unknown mechanism of action.[A178426] Methacarbamol has been shown to block spinal polysynaptic reflexes, decrease nerve transmission in spinal and supraspinal polysynaptic pathways, and prolong the refractory period of muscle cells.[A178426,A178411] Methocarbamol does not act as a local anesthetic upon injection.[A178411] In animal studies, methocarbamol also prevents convulsions after electric shock.[A178426]
|
The mechanism of action of methocarbamol is thought to be dependant on its central nervous system depressant activity.[A31312] This action may be mediated through blocking spinal polysynaptic reflexes, decreasing nerve transmission in spinal and supraspinal polysynaptic pathways, and prolonging the refractory period of muscle cells.[A178426,A178411] Methocarbamol has been found to have no effect on contraction of muscle fibres, motor end plates, or nerve fibres.[L6268]
|
The time to maximum concentration is 1.1 hours for both healthy patients and those on hemodialysis.[A636] The maximum plasma concentration is 21.3mg/L for healthy patients and 28.7mg/L in hemodialysis patients.[A636] The area under the curve for healthy patients is 52.5mg/L\*hr and 87.1mg/L*hr in hemodialysis patients.[A636] AUC% based on terminal elimination half life is 2% for healthy patients and 4% for hemodialysis patients.[A636]
Older studies report maximum plasma concentrations in 0.5 hours.[A178366]
|
Methocarbamol is metabolized in the liver by demethylation to 3-(2-hydroxyphenoxy)-1,2-propanediol-1-carbamate or hydroxylation to 3-(4-hydroxy-2-methoxyphenoxy)-1,2-propanediol-1-carbamate.[A178366] Methocarbamol and its metabolites are conjugated through glucuronidation or sulfation.[A178366]
|
Overdose of methocarbamol may be associated with alcohol and other central nervous system depressants.[Label] Patients may experience nausea, drowsiness, blurred vision, hypotension, seizures, and coma.[Label] Treatment of overdose is generally through airway maintenance, monitoring urinary output, vital signs, and giving fluid intravenously if necessary.[Label]
The oral LD50 in rats is 3576.2mg/kg.[L6295]
The FDA has classified methocarbamol as pregnancy category C.[Label] Animal and human studies have not been performed to determine the risks to a fetus, however fetal and congenital abnormalities have been reported.[Label] Methocarbamol is excreted in the milk of dogs, however it is unknown if this is also the case for humans.[Label] Caution should be exercised when taking methocarbamol while breastfeeding.[Label]
Studies to assess the carcinogenicity, mutagenicity, or effects on fertility of methocarbamol have not been performed.[Label]
|
The elimination half life is 1.14 hours in healthy subjects and 1.24 hours in subjects with renal insufficiency.[A636] Older studies report half lives of 1.6-2.15 hours.[A178366]
|
Methocarbamol is 46-50% protein bound in healthy patients and 47.3-48.9% protein bound in hemodialysis patients.[A636]
|
In humans the majority of the dose is eliminated in the urine.[A178366] In dogs, 88.85% of the dose is eliminated in urine and 2.14% in the feces.[A178366] In rats, 84.5-92.5% of the dose is eliminated in the urine and 0-13.3% is eliminated in the feces.[A178366]
|
Volume of distribution data in humans is scarce. In horses, the volume of distribution is 515-942mL/kg at steady state or 724-1130mL/kg.[A178426]
|
0.2-0.8L/h/kg.[L6268]
|
Organic compounds
|
Benzenoids
|
Phenol ethers
|
Anisoles
|
[
"approved",
"vet_approved"
] |
[
"M03BA",
"M03B",
"M03",
"M",
"M03BA",
"M03B",
"M03",
"M",
"M03BA",
"M03B",
"M03",
"M"
] |
[
"Humans and other mammals"
] |
[
{
"cost": "1.68",
"description": "Robaxin 500 mg tablet",
"unit": "tablet"
},
{
"cost": "1.99",
"description": "Robaxin-750 tablet",
"unit": "tablet"
},
{
"cost": "2.2",
"description": "Robaxin 100 mg/ml vial",
"unit": "ml"
},
{
"cost": "2.48",
"description": "Robaxin-750 750 mg tablet",
"unit": "tablet"
},
{
"cost": "0.38",
"description": "Methocarbamol 500 mg tablet",
"unit": "tablet"
},
{
"cost": "0.49",
"description": "Methocarbamol 750 mg tablet",
"unit": "tablet"
},
{
"cost": "0.95",
"description": "Methocarbamol powder",
"unit": "g"
}
] |
[] |
(RS)-2-hydroxy-3-(2-methoxyphenoxy)propyl carbamate | Methocarbamol | Méthocarbamol | Methocarbamolum | Metocarbamol | Metocarbamolo | 4.2.1.1 | CA-I | CAB | Carbonate dehydratase I | Carbonic anhydrase B | Carbonic anhydrase I | Cyanamide hydratase CA1
|
[
"A.S.A. With Methocarbamol Night-time Extra Strength",
"Acetaminophen 325mg + Methocarbamol 400mg Caplets",
"Acetaminophen 500mg + Methocarbamol 400mg Extra Strength Caplets",
"Advil Back Pain",
"Analgesic and Muscle Relaxant",
"Analgesic and Muscle Relaxant Caplets",
"Aspirin Backache",
"Aspirin Night-time",
"Axacet-C1/8",
"Axisal-C1/8",
"Axum",
"Dodd's Back-ease Muscle Spasm and Back Pain Relief",
"Dodd's Extra Strength Back-ease",
"Douleurs Musculaires Et Les Courbatures Extra Fort/muscle and Back Pain Relief Extra Strength",
"Extra Strength Aspirin Backache",
"Extra Strength Back Pain",
"Extra Strength Body Pain Night",
"Extra Strength Muscle & Back Pain Asa 500 Mg Methocarbamol 400 Mg & Acetylsalicylic Acid 500 mg",
"Extra Strength Muscle & Back Pain Relief",
"Extra Strength Muscle & Back Pain Relief",
"Extra Strength Muscle & Back Pain Relief With Asa",
"Extra Strength Tylenol Back Pain",
"Extra Strength Tylenol Body Pain Night",
"Ibuprofen+methocarbamol Caplets",
"Methcarbamol",
"Methocarb 500-EZS",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
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"Methocarbamol",
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"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
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"Methocarbamol",
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"Methocarbamol",
"Methocarbamol",
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"Methocarbamol",
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"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol",
"Methocarbamol and Aspirin",
"Methocarbamol Granules DC 90%",
"Methocarbamol Inj 100mg/ml",
"Methocarbamol Omega",
"Methocarbamol Tablets, USP, 500 mg",
"Methocarbamol Tablets, USP, 500 mg",
"Methocarbamol Tablets, USP, 500 mg",
"Methocarbamol Tablets, USP, 750 mg",
"Methocarbamol Tablets, USP, 750 mg",
"Methocarbamol Tablets, USP, 750 mg",
"Methocarbomal Granules DC 90%",
"Methoxacet",
"Methoxacet Extra Strength",
"Methoxacet-C 1/8",
"Methoxisal",
"Methoxisal Extra Strength",
"Methoxisal-C 1/2",
"Methoxisal-C 1/4",
"Methoxisal-C 1/8",
"Midol Night-time",
"Motrin Platinum Muscle & Body",
"Muscle & Back Pain Asa 325 Mg Methocarbamol 400 Mg & Acetylsalicylic Acid 325 mg",
"Muscle & Back Pain Relief",
"Muscle & Back Pain Relief",
"Muscle & Back Pain Relief - 8",
"Muscle & Back Pain Relief Caplets",
"Muscle & Back Pain Relief Caplets",
"Muscle & Back Pain Relief Extra Strength",
"Muscle & Back Pain Relief With Ibuprofen",
"Muscle & Back Pain Relief-8",
"Muscle and Back Pain Platinum Relief",
"Muscle and Back Pain Relief",
"Muscle and Back Pain Relief",
"Muscle and Back Pain Relief",
"Muscle and Back Pain Relief",
"Muscle and Back Pain Relief",
"Muscle and Back Pain Relief - 8 Tablets",
"Muscle and Back Pain Relief Caplets",
"Muscle and Back Pain Relief Extra Strength",
"Muscle and Back Pain Relief Extra Strength",
"Muscle and Back Pain Relief Extra Strength",
"Muscle and Back Pain Relief Extra Strength",
"Muscle and Back Pain Relief Regular Strength Tablets",
"Muscle and Back Pain Relief With Asa",
"Muscle and Back Pain Relief With Asa Extra Strength",
"Muscle and Back Pain Relief-8",
"Muscle Relaxant and Analgesic",
"Muscle Relaxant and Analgesic Caplets",
"Muscle Relaxant and Back Pain Relief Extra Strength Tablets",
"Muscle Relaxant and Back Pain Relief Regular Strength Tablets",
"Nighttime Body Pain",
"Platinum Muscle and Back Pain Relief",
"PMS-methocarbamol Inj 100mg/ml",
"Regular Strength Analgesic & Muscle Relaxant Caplets",
"Regular Strength Tylenol Back Pain",
"Regular Strength Tylenol Body Pain Night",
"Relaxophen Caplets",
"Robax Platinum",
"Robaxacet",
"Robaxacet Extra Strength",
"Robaxacet Tablets",
"Robaxacet-8",
"Robaximol Inj 100mg/ml",
"Robaxin",
"Robaxin",
"Robaxin",
"Robaxin",
"Robaxin",
"Robaxin",
"Robaxin",
"Robaxin",
"Robaxin",
"Robaxin",
"Robaxin",
"Robaxin",
"Robaxin 750",
"Robaxin Inj 100mg/ml",
"Robaxin Injectable Liq 100mg/ml",
"Robaxisal C 1/2",
"Robaxisal C 1/4",
"Robaxisal C-1/8 Tablets",
"Robaxisal Caplets",
"Robaxisal Extra Strength",
"Robaxisal Tablets",
"Soulagement Des Douleurs Musculaires & Courbatures Extra Fort",
"Spasmhalt-8",
"Spasmhalt-asa-8",
"Summit Ultra",
"Super Extra Strength Aspirin Backache",
"Tanlor"
] |
[
"Bolaxin",
"Carbaflex",
"Delaxin",
"DoloVisan",
"Fubaxin",
"Lumirelax",
"Metocarbamol",
"Mioflex",
"Miorel",
"Musxan",
"Ortoton",
"Rebamol",
"Robaxin-750",
"Robinax",
"Sinaxar",
"Taspan"
] |
[
"Methocarbamol and Aspirin",
"Robaxacet",
"Methoxacet",
"Robaxisal Extra Strength",
"Robaxacet Extra Strength",
"Muscle and Back Pain Relief",
"Methoxacet Extra Strength",
"Methoxisal Extra Strength",
"Muscle and Back Pain Relief Extra Strength",
"Robax Platinum",
"Muscle and Back Pain Relief Regular Strength Tablets",
"Muscle Relaxant and Back Pain Relief Extra Strength Tablets",
"Extra Strength Muscle & Back Pain Asa 500 Mg Methocarbamol 400 Mg & Acetylsalicylic Acid 500 mg",
"Extra Strength Tylenol Back Pain",
"Analgesic and Muscle Relaxant Caplets",
"Axum",
"Muscle & Back Pain Relief With Ibuprofen",
"Extra Strength Tylenol Body Pain Night",
"Summit Ultra",
"Motrin Platinum Muscle & Body",
"Extra Strength Muscle & Back Pain Relief With Asa",
"Robaxacet Tablets",
"Robaxisal Tablets",
"Robaxisal Caplets",
"Extra Strength Aspirin Backache",
"Dodd's Back-ease Muscle Spasm and Back Pain Relief",
"Methoxisal",
"Muscle and Back Pain Relief With Asa",
"Dodd's Extra Strength Back-ease",
"Muscle Relaxant and Analgesic",
"Aspirin Night-time",
"Midol Night-time",
"Douleurs Musculaires Et Les Courbatures Extra Fort/muscle and Back Pain Relief Extra Strength",
"Muscle Relaxant and Back Pain Relief Regular Strength Tablets",
"Soulagement Des Douleurs Musculaires & Courbatures Extra Fort",
"A.S.A. With Methocarbamol Night-time Extra Strength",
"Advil Back Pain",
"Nighttime Body Pain",
"Regular Strength Tylenol Body Pain Night",
"Regular Strength Tylenol Back Pain",
"Extra Strength Body Pain Night",
"Regular Strength Analgesic & Muscle Relaxant Caplets",
"Extra Strength Muscle & Back Pain Relief",
"Muscle and Back Pain Relief",
"Muscle and Back Pain Relief",
"Muscle and Back Pain Relief Extra Strength",
"Muscle and Back Pain Relief Extra Strength",
"Muscle & Back Pain Relief Extra Strength",
"Muscle & Back Pain Relief",
"Muscle & Back Pain Relief",
"Acetaminophen 325mg + Methocarbamol 400mg Caplets",
"Acetaminophen 500mg + Methocarbamol 400mg Extra Strength Caplets",
"Extra Strength Back Pain",
"Spasmhalt-8",
"Spasmhalt-asa-8",
"Muscle & Back Pain Relief-8",
"Ibuprofen+methocarbamol Caplets",
"Muscle Relaxant and Analgesic Caplets",
"Relaxophen Caplets",
"Muscle & Back Pain Asa 325 Mg Methocarbamol 400 Mg & Acetylsalicylic Acid 325 mg",
"Platinum Muscle and Back Pain Relief",
"Muscle and Back Pain Relief",
"Super Extra Strength Aspirin Backache",
"Aspirin Backache",
"Muscle and Back Pain Relief - 8 Tablets",
"Axacet-C1/8",
"Axisal-C1/8",
"Muscle and Back Pain Relief With Asa Extra Strength",
"Methoxisal-C 1/8",
"Methoxisal-C 1/4",
"Methoxisal-C 1/2",
"Muscle and Back Pain Relief-8",
"Muscle & Back Pain Relief Caplets",
"Muscle and Back Pain Relief Extra Strength",
"Methoxacet-C 1/8",
"Analgesic and Muscle Relaxant",
"Robaxacet-8",
"Robaxisal C 1/4",
"Robaxisal C 1/2",
"Muscle & Back Pain Relief Caplets",
"Extra Strength Muscle & Back Pain Relief",
"Muscle & Back Pain Relief - 8",
"Robaxisal C-1/8 Tablets",
"Muscle and Back Pain Platinum Relief",
"Muscle and Back Pain Relief",
"Muscle and Back Pain Relief Caplets"
] |
[
"P00915"
] |
[] |
[] |
[] |
DB00424
|
Hyoscyamine
|
Hyoscyamine is a tropane alkaloid and the levo-isomer of [atropine].[A228423] It is commonly extracted from plants in the _Solanaceae_ or nightshade family.[A228423] Research into the action of hyoscyamine in published literature dates back to 1826.[A228713] Hyoscyamine is used for a wide variety of treatments and therapeutics due to its antimuscarinic properties.[L31548,L31553]
Although hyoscyamine is marketed in the United States, it is not FDA approved.[L31548,L31553]
|
solid
|
As a drug that is not FDA approved, hyscyamine has no official indications.[L31548,L31553] Intravenous hysocyamine has been used to reduce gastric motility, reduce pancreatic pain and secretions, to facilitate imaging of the gastrointestinal tract, treat anticholinesterase toxicity, treat certain cases of partial heart block, improve visualization of the kidneys, and for symptomatic relief of biliary and renal colic.[L31548] Intravenous hyoscyamine is also used pre-operatively to reduce secretions of the mouth and respiratory tract to facilitate intubation.[L31548] Oral hyoscyamine is used to treat functional intestinal disorders, for symptomatic relief of biliary and renal colic, and symptomatic relief of acute rhinitis.[L31553]
|
Hyoscyamine is not FDA approved, and so it has not official indications.[L31548,L31553] However, it is used as an antimuscarinic agent in a number of treatments and therapies.[L31548,L31553] Hyoscyamine has a short duration of action as it may need to be given multiple times per day.[L31548,L31553] Patients should be counselled regarding the risks and signs of anticholinergic toxicity.[L31548,L31553]
|
Hyoscyamine competitively and non-selectively antagonises muscarinic receptors in the smooth muscle, cardiac muscle, sino-atrial node, atrioventricular node, exocrine nodes, gastrointestinal tract, and respiratory tract.[A228613,L31548,L31553] Antagonism of muscarinic M1, M4, and M5 receptors in the central nervous system lead to cognitive impairment; antagonism of M2 in the sinoatrial and atrioventricular nodes leads to increases in heart rate and atrial contractility; and antagonism of M3 in smooth muscle results in reduced peristalsis, bladder contraction, salivary secretions, gastric secretions, bronchial secretions, sweating, increased bronchodilation, mydriasis, and cycloplegia.[A228613,A228623,A228633]
|
Hyoscyamine is completely absorbed by sublingual and oral routes, though exact data regarding the C<sub>max</sub>, T<sub>max</sub>, and AUC are not readily available.[L31548,L31553]
|
Hyoscyamine is largely unmetabolized, however a small amount is hydrolyzed into tropine and tropic acid.[A228368,L31553]
|
Patients experiencing an overdose may present with headache, nausea, vomiting, dizziness, dry mouth, difficulty in swallowing, dilated pupils, blurred vision, urinary retention, hot dry and flushed skin, tachycardia, hypertension, hypotension, respiratory depression, CNS stimulation, fever, ataxia, excitation, lethargy, stupor, coma, and paralysis.[L31548,L31553] Patients should be treated with symptomatic and supportive therapy which may include emesis, gastric lavage, activated charcoal, artificial respiration, or intravenous [physostigmine].[A228423,L31548,L31553] Dialysis is expected to remove hyoscyamine sulfate from circulation.[L31548,L31553]
|
The half life of hyoscyamine is 3.5 hours.[L31548,L31553]
| null |
The majority of hyoscyamine is eliminated in the urine as the unmetabolized parent compound.[L31548,L31553]
| null | null |
Organic compounds
|
Alkaloids and derivatives
|
Tropane alkaloids
| null |
[
"approved"
] |
[
"A03BA",
"A03B",
"A03",
"A",
"A03CB",
"A03C",
"A03",
"A"
] |
[
"Humans and other mammals"
] |
[
{
"cost": "1.08",
"description": "Levsin 0.125 mg tablet",
"unit": "tablet"
},
{
"cost": "1.17",
"description": "Symax-sl 0.125 mg tablet sl",
"unit": "tablet"
},
{
"cost": "1.21",
"description": "Symax fastabs 0.125 mg tablet",
"unit": "tablet"
},
{
"cost": "1.24",
"description": "Levsin/SL 0.125 mg Sublingual Tabs",
"unit": "tab"
},
{
"cost": "1.4",
"description": "Symax-sr 0.375 mg tablet",
"unit": "tablet"
},
{
"cost": "1.44",
"description": "Levbid 0.375 mg tablet sa",
"unit": "tablet"
},
{
"cost": "1.66",
"description": "Hyoscyamine Sulfate CR 0.375 mg 12 Hour tablet",
"unit": "tablet"
},
{
"cost": "2.09",
"description": "Levbid er 0.375 mg tablet",
"unit": "tablet"
},
{
"cost": "2.12",
"description": "Levbid 0.375 mg 12 Hour tablet",
"unit": "tablet"
},
{
"cost": "2.4",
"description": "Symax duotab",
"unit": "tablet"
},
{
"cost": "3.29",
"description": "Symax-SL 0.125 mg Sublingual Tabs",
"unit": "tab"
},
{
"cost": "3.73",
"description": "Symax Duotab 0.375 mg Controlled Release Tabs",
"unit": "tab"
},
{
"cost": "25.69",
"description": "Hyoscyamine sulfate powder",
"unit": "g"
},
{
"cost": "27.33",
"description": "Levsin 0.5 mg/ml ampul",
"unit": "ml"
},
{
"cost": "49.09",
"description": "Levsin 0.125 mg/ml Solution 15ml Bottle",
"unit": "bottle"
},
{
"cost": "0.26",
"description": "Anaspaz 0.125 mg tablet sl",
"unit": "tablet"
},
{
"cost": "0.29",
"description": "Levsin 0.125 mg/5ml Elixir",
"unit": "ml"
},
{
"cost": "0.36",
"description": "Anaspaz 0.125 mg Dispersible Tablet",
"unit": "dispersible tablet"
},
{
"cost": "0.39",
"description": "Hyoscyamine sul 0.15 mg tablet sl",
"unit": "tablet"
},
{
"cost": "0.53",
"description": "Hyoscyamine 0.125 mg tablet sl",
"unit": "tablet"
},
{
"cost": "0.64",
"description": "Hyoscyamine su 0.125 mg tablet",
"unit": "tablet"
},
{
"cost": "0.79",
"description": "Hyoscyamine sulf 0.125 mg tablet",
"unit": "tablet"
},
{
"cost": "0.83",
"description": "Hyoscyamine Sulfate 0.125 mg Dispersible Tablet",
"unit": "dispersible tablet"
},
{
"cost": "0.86",
"description": "Hyomax-sl 0.125 mg tablet sl",
"unit": "tablet"
},
{
"cost": "0.88",
"description": "Hyoscyamine Sulfate 0.125 mg Sublingual Tabs",
"unit": "tab"
},
{
"cost": "0.91",
"description": "Nulev 0.125 mg tablet",
"unit": "tablet"
},
{
"cost": "0.93",
"description": "Hyoscyamine Sulfate 0.125 mg tablet",
"unit": "tablet"
},
{
"cost": "0.97",
"description": "Levsin-sl 0.125 mg tablet sl",
"unit": "tablet"
}
] |
[] |
(−)-atropine | (−)-hyoscyamine | (S)-(−)-hyoscyamine | (S)-atropine | [3(S)-endo]-α-(hydroxymethyl)benzeneacetic acid 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester | Daturin | Daturine | Duboisine | Hyoscyamin | Hyoscyamine | Hyoscyaminum | L-Hyoscyamine | L-Tropine tropate | Tropine-L-tropate | 4.6.1.1 | Adenylate cyclase type I | Adenylyl cyclase 1 | ATP pyrophosphate-lyase 1 | Ca(2+)/calmodulin-activated adenylyl cyclase
|
[
"Anaspaz",
"Anaspaz",
"Azuphen Mb",
"B-Donna",
"Belladonna Alkaloids with Phenobarbital",
"Belladonna Alkaloids with Phenobarbital",
"Belladonna Alkaloids with Phenobartbital",
"Belladonna Alkaloids with Phenobartbital",
"Belladonna Alkaloids with Phenobartbital",
"Belladonna Alkaloids with Phenobartbital",
"Belladonna Alkaloids with Phenobartbital",
"Belladonna Alkaloids with Phenobartbital",
"Calmitol Itching Relief Ont",
"Darcalma",
"Darcalma",
"Darpaz",
"Diban Cap",
"Diban Cap",
"Donnagel Liq",
"Donnagel Liq",
"Donnatal",
"Donnatal",
"Donnatal",
"Donnatal",
"Donnatal",
"Donnatal",
"Donnatal",
"Donnatal",
"Donnatal",
"Donnatal",
"Donnatal",
"Donnatal",
"Donnatal",
"Donnatal",
"Donnatal",
"Donnatal",
"Donnatal",
"Donnatal",
"Donnatal Elixir",
"Donnatal Elixir",
"Donnatal Extentabs",
"Donnatal Extentabs",
"Donnatal Extentabs",
"Donnatal Extentabs Srt",
"Donnatal Tab",
"Ed-spaz",
"Hyolev Mb",
"HyoMax",
"HyoMax-DT",
"HyoMax-FT",
"HyoMax-SL",
"HyoMax-SR",
"Hyophen",
"Hyophen",
"Hyoscyamine",
"Hyoscyamine",
"Hyoscyamine",
"Hyoscyamine",
"Hyoscyamine",
"Hyoscyamine ER",
"Hyoscyamine ER",
"Hyoscyamine S L",
"Hyoscyamine SL",
"Hyoscyamine SL",
"Hyoscyamine SL",
"Hyoscyamine SL",
"Hyoscyamine Sulfate",
"Hyoscyamine Sulfate",
"Hyoscyamine Sulfate",
"Hyoscyamine Sulfate",
"Hyoscyamine Sulfate",
"Hyoscyamine Sulfate",
"Hyoscyamine Sulfate",
"Hyoscyamine Sulfate",
"Hyoscyamine Sulfate",
"Hyoscyamine Sulfate",
"Hyoscyamine Sulfate",
"Hyoscyamine Sulfate",
"Hyoscyamine Sulfate",
"Hyoscyamine Sulfate",
"Hyoscyamine Sulfate",
"Hyoscyamine Sulfate",
"Hyoscyamine Sulfate",
"Hyoscyamine Sulfate",
"Hyoscyamine Sulfate",
"Hyoscyamine Sulfate",
"Hyoscyamine Sulfate",
"Hyoscyamine Sulfate",
"Hyoscyamine Sulfate",
"Hyoscyamine Sulfate",
"Hyoscyamine Sulfate",
"Hyoscyamine Sulfate",
"Hyoscyamine Sulfate",
"Hyoscyamine Sulfate",
"Hyoscyamine Sulfate",
"Hyoscyamine Sulfate",
"Hyoscyamine Sulfate",
"Hyoscyamine Sulfate",
"Hyoscyamine Sulfate",
"Hyoscyamine Sulfate",
"Hyoscyamine Sulfate",
"Hyoscyamine Sulfate",
"Hyoscyamine Sulfate",
"Hyoscyamine Sulfate",
"Hyoscyamine Sulfate",
"Hyoscyamine Sulfate",
"Hyoscyamine Sulfate",
"Hyoscyamine Sulfate",
"Hyoscyamine Sulfate",
"Hyoscyamine Sulfate",
"Hyoscyamine Sulfate",
"Hyoscyamine Sulfate",
"Hyoscyamine Sulfate",
"Hyoscyamine Sulfate",
"Hyoscyamine Sulfate",
"Hyoscyamine Sulfate",
"Hyoscyamine Sulfate",
"Hyoscyamine Sulfate",
"Hyoscyamine Sulfate",
"Hyoscyamine Sulfate",
"Hyoscyamine Sulfate",
"Hyoscyamine Sulfate",
"Hyoscyamine Sulfate",
"Hyoscyamine Sulfate",
"Hyoscyamine Sulfate",
"Hyoscyamine Sulfate",
"Hyoscyamine Sulfate",
"Hyoscyamine Sulfate",
"Hyoscyamine Sulfate",
"Hyoscyamine Sulfate",
"Hyoscyamine sulfate",
"Hyoscyamine Sulfate",
"Hyoscyamine sulfate",
"Hyoscyamine Sulfate",
"Hyoscyamine Sulfate",
"Hyoscyamine Sulfate",
"Hyoscyamine Sulfate",
"Hyoscyamine Sulfate",
"Hyoscyamine Sulfate",
"Hyoscyamine Sulfate",
"Hyoscyamine Sulfate",
"Hyoscyamine Sulfate",
"Hyoscyamine sulfate",
"Hyoscyamine Sulfate",
"Hyoscyamine Sulfate",
"Hyoscyamine Sulfate",
"Hyoscyamine Sulfate",
"Hyoscyamine sulfate",
"Hyoscyamine Sulfate",
"Hyoscyamine Sulfate",
"Hyoscyamine Sulfate Drops",
"Hyoscyamine Sulfate Drops",
"Hyoscyamine Sulfate Extended-Release",
"Hyoscyamine Sulfate Extended-Release",
"Hyoscyamine Sulfate Extended-Release",
"Hyoscyamine Sulfate Extended-Release",
"Hyoscyamine Sulfate Extended-Release",
"Hyoscyamine Sulfate ODT",
"Hyoscyamine Sulfate SL",
"Hyoscyamine Sulfate SL",
"Hyoscyamine Sulfate Sl",
"Hyoscyamine Sulfate SL",
"Hyoscyamine Sulfate SL",
"Hyoscyamine Sulfate SL",
"Hyoscyamine Sulfate SL",
"Hyoscyamine Sulfate SL",
"Hyoscyamine Sulfate Sublingual",
"Hyoscyamine sulfate Sublingual",
"Hyoscyamine Sulfate TAB",
"Hyoscyamine Sulfate TAB",
"Hyoscyamine Sulfate TAB",
"Hyoscyamine Sulfate TAB",
"Hyosyne",
"Hyosyne",
"Hyosyne",
"Hyosyne",
"Indiomin Mb",
"Levbid",
"Levsin",
"Levsin",
"Levsin",
"Levsin",
"Levsin",
"Levsin Drops 0.125mg/ml",
"Levsin SL",
"Me NaPhos MB Hyo 1",
"Me-PB-Hyos",
"Me-PB-Hyos",
"Methylphen",
"NuLev",
"Oscimin",
"Oscimin",
"Oscimin",
"Oscimin",
"PB Hyos",
"Phenazopyridine Hydrochloride, Hyoscyamine Hydrobromide, and Butabarbital",
"Phenazopyridine Plus",
"Phenobarbital With Belladonna Alkaloids",
"Phenobarbital With Belladonna Alkaloids",
"Phenobarbital with Belladonna Alkaloids",
"Phenobarbital With Belladonna Alkaloids",
"Phenobarbital With Belladonna Alkaloids",
"Phenobarbital With Belladonna Alkaloids",
"Phenobarbital With Belladonna Alkaloids",
"Phenobarbital with Belladonna Alkaloids",
"Phenobarbital with Belladonna Alkaloids - Grape",
"Phenobarbital with Belladonna Alkaloids - Grape",
"Phenobarbital with Belladonna Alkaloids - Mint",
"Phenobarbital with Belladonna Alkaloids - Mint",
"Phenobarbital, Hyoscyamine Sulfate, Atropine Sulfate and Scopolamine Hydrobromide",
"Phenobarbital, Hyoscyamine Sulfate, Atropine Sulfate and Scopolamine Hydrobromide",
"Phenobarbital, Hyoscyamine Sulfate, Atropine Sulfate, Scopolamine Hydrobromide",
"Phenobarbital, Hyoscyamine Sulfate, Atropine Sulfate, Scopolamine Hydrobromide",
"Phenobarbital, Hyoscyamine Sulfate, Atropine Sulfate, Scopolamine Hydrobromide",
"Phenobarbital, Hyoscyamine Sulfate, Atropine Sulfate, Scopolamine Hydrobromide",
"Phenohytro",
"Phenohytro",
"Phenohytro",
"Phenohytro",
"Phenohytro",
"Phosenamine",
"Phosphasal",
"Phosphasal",
"Prosed/DS",
"Pyrelle H.B.",
"Quadrapax",
"Quadrapax",
"Re-PB Hyos",
"Re-PB Hyos",
"Re-PB Hyos",
"Re-PB Hyos Elixir",
"Se-donna Pb Hyos",
"Servira",
"Servira",
"Symax Duotab",
"Symax FasTab",
"Symax SL",
"Symax SR",
"UR N-C Urinary Antiseptic",
"Uralgic",
"Uramit Mb",
"Urelle",
"Urelle",
"Uretron D/S",
"Uribel",
"Uribel",
"Uribel Tabs",
"Urimar-T",
"Urimar-T",
"Urimar-T Caps",
"Urin D/S",
"Urised",
"UrNeva",
"Uro-458",
"Uro-BLUE",
"Uro-L",
"Uro-MP",
"Uro-SP",
"UroAv-81",
"UroAv-81",
"UroAv-B",
"UroAv-B",
"Urogesic Blue",
"Urogesic Blue",
"Urolet Mb",
"Urophen Mb",
"Ustell",
"Ustell",
"Uta",
"Uta",
"Utira-C",
"Utira-C",
"Vilamit MB",
"Vilevev MB",
"Vitetal"
] |
[
"Acupaz",
"Anapaz",
"Atropen",
"Boots Travel Calm",
"Buwecon",
"Cystospaz",
"Cytospaz",
"Donnamar",
"Egazil",
"Levsinex",
"Symax"
] |
[
"Darcalma",
"Pyrelle H.B.",
"Darcalma",
"Methylphen",
"Darpaz",
"Phosenamine",
"Phenazopyridine Plus",
"Phenazopyridine Hydrochloride, Hyoscyamine Hydrobromide, and Butabarbital",
"Prosed/DS",
"Urin D/S",
"Uro-BLUE",
"Utira-C",
"Uralgic",
"UR N-C Urinary Antiseptic",
"Uro-L",
"Ustell",
"Uribel",
"Phosphasal",
"Urolet Mb",
"Urophen Mb",
"Hyolev Mb",
"Uramit Mb",
"Azuphen Mb",
"Uta",
"Urimar-T",
"Hyophen",
"Indiomin Mb",
"Urogesic Blue",
"UroAv-B",
"UroAv-81",
"Donnatal Extentabs",
"Urelle",
"Me NaPhos MB Hyo 1",
"Ustell",
"Vilamit MB",
"Vilevev MB",
"Uribel",
"Utira-C",
"Phosphasal",
"Urogesic Blue",
"Hyophen",
"UroAv-B",
"UroAv-81",
"Uro-458",
"Uro-MP",
"Urelle",
"Uta",
"Phenobarbital With Belladonna Alkaloids",
"Phenohytro",
"Phenobarbital With Belladonna Alkaloids",
"Phenobarbital with Belladonna Alkaloids",
"Phenobarbital With Belladonna Alkaloids",
"Urimar-T",
"Donnatal",
"Phenobarbital With Belladonna Alkaloids",
"Phenobarbital With Belladonna Alkaloids",
"Phenobarbital with Belladonna Alkaloids - Mint",
"Phenobarbital with Belladonna Alkaloids - Grape",
"Phenobarbital, Hyoscyamine Sulfate, Atropine Sulfate, Scopolamine Hydrobromide",
"Phenobarbital, Hyoscyamine Sulfate, Atropine Sulfate, Scopolamine Hydrobromide",
"Phenobarbital, Hyoscyamine Sulfate, Atropine Sulfate and Scopolamine Hydrobromide",
"Donnatal",
"Donnatal",
"Donnatal",
"Calmitol Itching Relief Ont",
"Donnatal Elixir",
"Donnatal Extentabs",
"Diban Cap",
"Donnagel Liq",
"Donnatal Tab",
"Donnatal Extentabs Srt",
"Donnatal Elixir",
"Donnagel Liq",
"Diban Cap",
"Re-PB Hyos",
"Servira",
"Servira",
"Vitetal",
"Quadrapax",
"Re-PB Hyos Elixir",
"PB Hyos",
"Belladonna Alkaloids with Phenobartbital",
"Belladonna Alkaloids with Phenobartbital",
"Donnatal Extentabs",
"Donnatal",
"Belladonna Alkaloids with Phenobartbital",
"Donnatal",
"Belladonna Alkaloids with Phenobartbital",
"Belladonna Alkaloids with Phenobartbital",
"Re-PB Hyos",
"Donnatal",
"Donnatal",
"Donnatal",
"Donnatal",
"B-Donna",
"Se-donna Pb Hyos",
"Belladonna Alkaloids with Phenobarbital",
"Re-PB Hyos",
"Belladonna Alkaloids with Phenobartbital",
"Quadrapax",
"Donnatal",
"Phenobarbital With Belladonna Alkaloids",
"Donnatal",
"Urised",
"Donnatal",
"Phenohytro",
"Phenohytro",
"Phenohytro",
"Phenobarbital with Belladonna Alkaloids - Grape",
"Phenobarbital with Belladonna Alkaloids",
"Phenobarbital with Belladonna Alkaloids - Mint",
"Phenohytro",
"Phenobarbital, Hyoscyamine Sulfate, Atropine Sulfate and Scopolamine Hydrobromide",
"Phenobarbital, Hyoscyamine Sulfate, Atropine Sulfate, Scopolamine Hydrobromide",
"Phenobarbital, Hyoscyamine Sulfate, Atropine Sulfate, Scopolamine Hydrobromide",
"Donnatal",
"Donnatal",
"Me-PB-Hyos",
"Donnatal",
"Donnatal",
"Belladonna Alkaloids with Phenobarbital",
"Donnatal",
"Me-PB-Hyos",
"Uretron D/S",
"Uro-SP",
"UrNeva",
"Urimar-T Caps",
"Uribel Tabs"
] |
[
"P11229",
"P08912",
"P08172",
"P20309",
"P08173",
"Q08828"
] |
[] |
[] |
[] |
DB00425
|
Zolpidem
|
Zolpidem, also known as _Ambien_, is a hypnotic drug that was initially approved by the FDA in 1992 [FDA label]. Zolpidem improves sleep in patients with insomnia. It is aimed for use in patients with difficulties initiating sleep. This drug decreases the time to fall asleep (sleep latency), increases the duration of sleep, and decreases the number of awakenings during sleep in patients with temporary (transient) insomnia. It is available in both immediate acting and extended release forms [FDA label], [F3802].
Its tolerability profile is favorable when administered according to the manufacturer’s instructions, with a low risk of drug withdrawal, drug dependence, and drug tolerance [A175426]. In addition, zolpidem improves sleep quality in patients suffering from chronic insomnia and can show mild muscle relaxant properties [L5584]. Research also shows that zolpidem is rapid and effective in restoring brain function for patients in a vegetative state following brain injury. This drug has the propensity to completely or partially reverse the abnormal metabolism of damaged brain cells after injury [L5584], [A175444].
|
solid
|
This drug is indicated for the short-term treatment of insomnia in adults characterized by difficulties with sleep initiation [FDA label].
|
**Effects on the central nervous system (CNS)**
This drug has CNS depressant effects, which may include somnolence, decreased alertness, sedation, drowsiness, dizziness, and other changes in psychomotor function [FDA label]. Due to the above effects, the FDA has recommended an initial dose of zolpidem (immediate-acting) is a single dose of 5 mg for women and a single dose of 5 or 10 mg for men, immediately before bedtime with at least 7-8 hours remaining before the planned time of awakening [L5581]. Refer to product labeling for detailed information [F3802], [FDA label].
**Effects on memory**
Controlled studies in adults using objective measures of memory demonstrated no significant evidence of next-day memory impairment after the administration of zolpidem. On the contrary, in a clinical study involving the administration of zolpidem doses of 10 and 20 mg, a marked reduction in a next-morning recall of information relayed to subjects during peak drug effect (90 minutes after dosing) was observed. These subjects experienced a condition known as _anterograde amnesia_. Subjective evidence from adverse event data has suggested that anterograde amnesia may occur after zolpidem administration, mainly at doses above 10 mg [FDA label].
**Effects on psychomotor function**
This drug may cause decreased psychomotor performance. Additive psychomotor effects may occur with other drugs that cause depression of psychomotor function, including alcohol [FDA label]. Patients taking zolpidem should be cautioned against participating in hazardous activities or occupations requiring complete mental alertness or motor coordination, including operating machinery or driving a motor vehicle after ingesting the drug. Potential impairment of the performance of the above types of activities may also occur the day after zolpidem ingestion, especially at higher doses and ingestion of the extended-release form [FDA label], [F3802].
**Effects on insomnia and sleep stages**
Evidence suggests that this drug is associated with minimal rebound insomnia. During clinical trials with patients using zolpidem on an ‘as-needed’ basis, zolpidem use resulted in global improvements in sleep [A175426]. Zolpidem has been demonstrated to decrease sleep latency (the time it takes to fall asleep) for up to 35 days in controlled clinical studies [FDA label]. In studies measuring the percentage of sleep time spent in each sleep stage, zolpidem has primarily been shown to preserve sleep stages. Sleep time spent in stages 3 and 4 (deep sleep) was measured as similar to placebo with only minor and inconsistent changes in REM (paradoxical) sleep at the recommended dose [FDA label].
**Next-day residual effects**
In 2013, the FDA issued a statement warning that patients who take zolpidem extended-release (Ambien CR)―either 6.25 mg or 12.5 mg―should not drive or participate in other activities requiring full mental alertness the day after taking the drug, due to the fact that zolpidem concentrations can remain increased the next day, and impair the ability to perform these activities [L5581], [F3802]. Patients may decrease their risk of next-morning impairment by taking the lowest dose of their insomnia medicine that treats their symptoms, according to the FDA [L5590]. Specific dosing recommendations for both men and women are included in this statement [L5581]. This information is also available on product labeling [F3802], [FDA label].
**Rebound effects**
There was no polysomnographic (objective) evidence of rebound insomnia at normal doses, in studies evaluating sleep on the nights following discontinuation of zolpidem tartrate. Subjective evidence of impaired sleep in the elderly on the first post-treatment night was observed at doses higher than the recommended 5mg dose for elderly patients [FDA label].
|
Zolpidem, the active moiety of zolpidem tartrate, is a hypnotic substance with a chemical structure that is not related to the structure benzodiazepines, barbiturates, pyrrolopyrazines, pyrazolopyrimidines or other drugs exerting hypnotic effects. It interacts with a _GABA-BZ_ receptor complex and shares various pharmacological properties with the _benzodiazepine_ class of drugs [FDA label].
Subunit binding of the _GABAA_ receptor chloride channel macromolecular complex is thought to lead to the sedative, anticonvulsant, anxiolytic, and myorelaxant drug effects of zolpidem. The main regulatory site of the GABAA receptor complex can be found on its _alpha (α) subunit_ and is called the _benzodiazepine_ (BZ) or _omega (ω)_ receptor. At least three different subtypes of the (ω) receptor have been identified to this date [FDA label].
In contrast to benzodiazepine drugs, which are found to modulate all benzodiazepine receptor subtypes in a non-selective fashion, zolpidem binds the (BZ1) receptor specifically with a potent affinity for the alpha 1/alpha 5 subunits (in vitro) [FDA label]. More recent studies suggest that zolpidem binds primarily to the alpha 1, 2, and 3 subunits of the GABA receptor [A173896], [A10523], [A175567], and not the alpha 5 subunit.
The (_BZ1_) receptor is found primarily on the Lamina IV of the brain sensorimotor cortical regions, substantia nigra (pars reticulata), cerebellum molecular layer, olfactory bulb, ventral thalamic complex, pons, inferior colliculus, and globus pallidus. Specific and selective binding of zolpidem on the (BZ1) receptor is not considered absolute, however, this binding could potentially explain the relative lack of myorelaxant and anticonvulsant activity in animal studies in addition to the preservation of deep sleep (stages 3 and 4) in human studies of zolpidem at hypnotic doses [FDA label].
|
Zolpidem is rapidly absorbed from the gastrointestinal tract. In a single-dose crossover study in 45 healthy subjects given 5 and 10 mg zolpidem tartrate tablets, the average peak zolpidem concentrations (Cmax) were 59 and 121 ng/mL, respectively, occurring at a mean time (Tmax) of 1.6 hours for both doses [FDA label].
|
Zolpidem is metabolized to three pharmacologically by various hepatic cytochrome P450 (CYP) isoenzymes, mainly CYP3A4, but also CYP1A2 and CYP2C9 [A175429], [A175447].
Although zolpidem is heavily metabolized, all three metabolites are inactive [A175426].
The major metabolic routes in humans are oxidation of the methyl group on the phenyl ring or the methyl group on the imidazopyridine moiety, to produce carboxylic acids (metabolites I and II), and hydroxylation of one of the imidazopyridine groups (to produce metabolite X). Another less common pathway is by the oxidation of the methyl groups on the substituted amide [A175429].
|
Oral (male rat) LD<sub>50</sub> = 695 mg/kg [MSDS].
**Overdose**
Symptoms of overdose include impairment of consciousness ranging from somnolence to light coma, in addition to cardiorespiratory collapse resulting in fatal outcomes have been reported [FDA label].
**Withdrawal effects**
Following rapid decreases in dose or abrupt discontinuation of zolpidem and other sedative/hypnotics, reports of signs and symptoms similar to those associated with withdrawal from other CNS-depressant drugs have been made [FDA label].
**Carcinogenesis**
Zolpidem was administered to rats and mice over a span of 2 years at dietary dosages of 4, 18, and 80 mg/kg/day. In mice, these doses are considered 26 to 520 times or 2 to 35 times the maximum 10 mg human dose, respectively. In rats, these doses are 43 to 876 times or 6 to 115 times the maximum 10 mg human dose. No evidence of carcinogenicity was seen in mice. Renal liposarcomas were observed in 4/100 rats (3 males, 1 female) receiving 80 mg/kg/day, and a renal lipoma was observed in one male rat at the 18 mg/kg/day dose. Incidence rates of lipoma and liposarcoma for zolpidem were similar to those seen in historical control cases, and the tumor findings are presumed to be a spontaneous occurrence, not causally related to zolpidem [FDA label].
**Mutagenesis**
Zolpidem did not show mutagenic activity in several tests including the Ames test, genotoxicity in mouse lymphoma cells in vitro, chromosomal aberrations in cultured human lymphocytes, abnormal DNA synthesis in rat hepatocytes in vitro, and the micronucleus test performed in mice [FDA label].
**Impairment of fertility**
In a rat reproduction study, the high dose (100 mg base/kg) of zolpidem lead to irregular estrus cycles and prolonged precoital intervals, however, there was no effect on male or female fertility after daily oral doses comparable to 5 to 130 times the recommended human dose. No effects on any other fertility parameters were observed [FDA label].
**Use in pregnancy**
This drug is considered a pregnancy category C drug. There are currently no sufficient conclusive studies completed in pregnant women to determine the safety of zolpidem use during pregnancy. Zolpidem should be used during pregnancy only if the potential benefit outweighs the potential risk to the fetus.
**Use in nursing**
From 0.004% to 0.019% of the total administered zolpidem dose is excreted into milk. The effect of zolpidem on the nursing infant is unknown at this time. Caution should be observed when zolpidem is administered to a nursing mother [FDA label].
|
The average zolpidem elimination half-life was 2.6 and 2.5 hours, for the 5 and 10 mg tablets, respectively [FDA label].
|
92.5 ± 0.1% [FDA label]
|
Zolpidem tartrate tablets are converted to inactive metabolites that are eliminated mainly by renal excretion [FDA label].
|
0.54 to 0.68 L/kg (in humans) [A175429]. In patients with long term renal insufficiency who were not yet on hemodialysis, the volume of distribution was found to increase significantly, AUC increased by 60%, and half-life nearly doubled [A175429].
|
In a clinical trial, after a 20mg dose, total clearance of zolpidem 0.24 to 0.27 ml/min/kg [A175429].
|
Organic compounds
|
Organoheterocyclic compounds
|
Azoles
|
Imidazoles
|
[
"approved"
] |
[
"N05CF",
"N05C",
"N05",
"N"
] |
[
"Humans and other mammals"
] |
[
{
"cost": "2.73",
"description": "Zolpidem tartrate 10 mg tablet",
"unit": "tablet"
},
{
"cost": "2.73",
"description": "Zolpidem tartrate 5 mg tablet",
"unit": "tablet"
},
{
"cost": "5.0",
"description": "Edluar 10 mg sl tablet",
"unit": "tablet"
},
{
"cost": "5.0",
"description": "Edluar 5 mg sl tablet",
"unit": "tablet"
},
{
"cost": "6.0",
"description": "Ambien CR 12.5 mg Controlled Release Tabs",
"unit": "tab"
},
{
"cost": "6.0",
"description": "Ambien CR 6.25 mg Controlled Release Tabs",
"unit": "tab"
},
{
"cost": "6.04",
"description": "Ambien 5 mg tablet",
"unit": "tablet"
},
{
"cost": "6.11",
"description": "Ambien 10 mg tablet",
"unit": "tablet"
},
{
"cost": "6.19",
"description": "Ambien cr 12.5 mg tablet",
"unit": "tablet"
},
{
"cost": "6.19",
"description": "Ambien cr 6.25 mg tablet",
"unit": "tablet"
}
] |
[
{
"approved": "2004-07-13",
"country": "United States",
"expires": "2019-09-24",
"number": "6761910"
},
{
"approved": "2013-08-20",
"country": "United States",
"expires": "2019-09-24",
"number": "8512747"
},
{
"approved": "2016-02-23",
"country": "United States",
"expires": "2030-05-13",
"number": "9265720"
},
{
"approved": "2003-02-04",
"country": "United States",
"expires": "2020-06-01",
"number": "6514531"
},
{
"approved": "2009-12-15",
"country": "United States",
"expires": "2017-10-01",
"number": "7632517"
},
{
"approved": "2010-02-09",
"country": "United States",
"expires": "2027-04-15",
"number": "7658945"
},
{
"approved": "2010-03-23",
"country": "United States",
"expires": "2025-02-16",
"number": "7682628"
},
{
"approved": "2012-08-14",
"country": "United States",
"expires": "2029-08-20",
"number": "8242131"
},
{
"approved": "2012-08-28",
"country": "United States",
"expires": "2025-02-16",
"number": "8252809"
},
{
"approved": "2017-03-21",
"country": "United States",
"expires": "2027-04-06",
"number": "9597281"
},
{
"approved": "2012-08-07",
"country": "United States",
"expires": "2032-08-07",
"number": "8236285"
}
] |
N,N,6-Trimethyl-2-(4-methylphenyl)imidazo(1,2-a)pyridine-3-acetamide | Zolpidem | Zolpidemum | GABA(A) receptor subunit alpha-1 | GABAAR subunit alpha-1 | GABA(A) receptor subunit gamma-3 | GABAAR subunit gamma-3 | GABA(A) receptor subunit alpha-2 | GABAAR subunit alpha-2 | GABA(A) receptor subunit alpha-3 | GABAAR subunit alpha-3 | GABA(A) receptor subunit gamma-2 | GABAAR subunit gamma-2 | (R)-limonene 6-monooxygenase | (S)-limonene 6-monooxygenase | (S)-limonene 7-monooxygenase | 1.14.14.1 | Cholesterol 25-hydroxylase | CYP2C10 | CYPIIC9 | Cytochrome P-450MP | Cytochrome P450 MP-4 | Cytochrome P450 MP-8 | Cytochrome P450 PB-1 | S-mephenytoin 4-hydroxylase | (R)-limonene 6-monooxygenase | (S)-limonene 6-monooxygenase | (S)-limonene 7-monooxygenase | 1.14.14.1 | CYPIIC17 | CYPIIC19 | Cytochrome P450-11A | Cytochrome P450-254C | Fenbendazole monooxygenase (4'-hydroxylating) | Mephenytoin 4-hydroxylase | 1.14.14.- | Cholesterol 25-hydroxylase | CYP2DL1 | CYPIID6 | Cytochrome P450-DB1 | Debrisoquine 4-hydroxylase | 1,4-cineole 2-exo-monooxygenase | 1,8-cineole 2-exo-monooxygenase | 1.14.14.1 | Albendazole monooxygenase (sulfoxide-forming) | Albendazole sulfoxidase | Cholesterol 25-hydroxylase | CYP3A3 | CYPIIIA3 | CYPIIIA4 | Cytochrome P450 3A3 | Cytochrome P450 HLp | Cytochrome P450 NF-25 | Cytochrome P450-PCN1 | Nifedipine oxidase | Quinine 3-monooxygenase | 1.14.14.1 | Cholesterol 25-hydroxylase | CYPIA2 | Cytochrome P(3)450 | Cytochrome P450 4 | Cytochrome P450-P3 | Hydroperoxy icosatetraenoate dehydratase
|
[
"Ag-zolpidem ODT",
"Ag-zolpidem ODT",
"Ambien",
"Ambien",
"Ambien",
"Ambien",
"Ambien",
"Ambien",
"Ambien",
"Ambien",
"Ambien",
"Ambien",
"Ambien",
"Ambien",
"Ambien",
"Ambien",
"Ambien",
"Ambien",
"Ambien",
"Ambien CR",
"Ambien CR",
"Ambien CR",
"Ambien CR",
"Ambien CR",
"Ambien CR",
"Ambien CR",
"Ambien CR",
"Ambien CR",
"Ambien CR",
"Ambien CR",
"Ambien CR",
"Ambien CR",
"Ambien CR",
"Apo-zolpidem ODT",
"Apo-zolpidem ODT",
"Edluar",
"Edluar",
"Edluar",
"Edluar",
"Gabazolpidem-5",
"Intermezzo",
"Intermezzo",
"Intermezzo",
"Intermezzo",
"Ivadal",
"Ivadal",
"Jamp Zolpidem ODT",
"Jamp Zolpidem ODT",
"Mint-zolpidem ODT",
"Mint-zolpidem ODT",
"PMS-zolpidem ODT",
"PMS-zolpidem ODT",
"Pro-zolpidem ODT",
"Pro-zolpidem ODT",
"Sentrazolpidem PM-5",
"Sublinox",
"Sublinox",
"Zolpidem",
"Zolpidem",
"Zolpidem",
"Zolpidem",
"Zolpidem",
"Zolpidem",
"Zolpidem",
"Zolpidem",
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"Zolpidem",
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"Zolpidem",
"Zolpidem",
"Zolpidem",
"Zolpidem",
"Zolpidem",
"Zolpidem",
"Zolpidem",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem tartrate",
"Zolpidem tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem tartrate",
"Zolpidem tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem tartrate",
"Zolpidem tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem tartrate",
"Zolpidem tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem tartrate",
"Zolpidem tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem tartrate",
"Zolpidem tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate",
"Zolpidem Tartrate ER",
"Zolpidem Tartrate Extended Release",
"Zolpidem Tartrate Extended-Release",
"Zolpidem Tartrate Extended-Release",
"Zolpidem Tartrate Extended-Release",
"Zolpidem Tartrate Extended-Release",
"Zolpidem Tartrate Extended-Release",
"Zolpidem Tartrate Extended-Release",
"Zolpidem Tartrate Extended-Release",
"Zolpidem Tartrate Extended-Release",
"Zolpidem Tartrate Extended-Release",
"Zolpidem Tartrate Extended-Release",
"Zolpidem Tartrate Extended-Release",
"Zolpidem Tartrate Extended-Release",
"Zolpidem Tartrate Extended-Release",
"Zolpidem Tartrate ODT",
"Zolpidem Tartrate ODT",
"Zolpidem tartrate sublingual",
"Zolpidem tartrate sublingual",
"Zolpimist",
"Zolpimist",
"ZolpiMIST"
] |
[
"Adormix",
"Bikalm",
"Dormizol",
"Hypnogen",
"Ivedal",
"Nasen",
"Nimadorm",
"Nottem",
"Stilnoct",
"Stilnox",
"Stilnox CR",
"Zolsana",
"Zoltis"
] |
[
"Gabazolpidem-5",
"Sentrazolpidem PM-5"
] |
[
"P14867",
"Q99928",
"P47869",
"P34903",
"P18507"
] |
[
"P11712",
"P33261",
"P10635",
"P08684",
"P05177"
] |
[] |
[] |
DB00426
|
Famciclovir
|
Famciclovir, marketed as Famvir by Novartis, is a guanine analogue used to treat herpes virus infections. It is most commonly used to treat herpes zoster (shingles). Famciclovir is a prodrug of penciclovir with higher oral bioavailability.
|
solid
|
For the treatment of acute herpes zoster (shingles). Also for the treatment or suppression of recurrent genital herpes in immunocompetent patients and treatment of recurrent mucocutaneous herpes simplex infections in HIV infected patients.
|
Famciclovir is a prodrug that undergoes rapid biotransformation to the active antiviral compound penciclovir. Penciclovir is an anti-viral drug which has inhibitory activity against herpes simplex virus types 1 (HSV-1) and 2 (HSV-2) and varicella zoster virus (VZV). Therefore, herpes viral DNA synthesis and replication are selectively inhibited.
|
Famciclovir undergoes rapid biotransformation to the active antiviral compound penciclovir, which has inhibitory activity against herpes simplex virus types 1 (HSV-1) and 2 (HSV-2) and varicella zoster virus (VZV). In cells infected with HSV-1, HSV-2 or VZV, viral thymidine kinase phosphorylates penciclovir to a monophosphate form that, in turn, is converted to penciclovir triphosphate by cellular kinases. In vitro studies demonstrate that penciclovir triphosphate inhibits HSV-2 DNA polymerase competitively with deoxyguanosine triphosphate. Consequently, herpes viral DNA synthesis and, therefore, replication are selectively inhibited.
|
77 %
|
Hepatic
|
Symptoms of overdose include constipation, diarrhea, dizziness, fatigue, fever, headache, nausea, and vomiting.
|
10 hours
|
20-25%
|
Active tubular secretion contributes to the renal elimination of penciclovir.
|
* 1.08±0.17 L/kg [healthy male subjects following a single intravenous dose of penciclovir at 400 mg administered as a 1-hour intravenous infusion]
|
* 36.6 +/- 6.3 L/hr [healthy male]
* 0.48 +/- 0.09 L/hr/kg [healthy male]
|
Organic compounds
|
Organoheterocyclic compounds
|
Imidazopyrimidines
|
Purines and purine derivatives
|
[
"approved",
"investigational"
] |
[
"J05AB",
"J05A",
"J05",
"J",
"S01AD",
"S01A",
"S01",
"S"
] |
[
"Human Herpes Virus"
] |
[
{
"cost": "5.34",
"description": "Famciclovir 125 mg tablet",
"unit": "tablet"
},
{
"cost": "5.81",
"description": "Famciclovir 250 mg tablet",
"unit": "tablet"
},
{
"cost": "6.59",
"description": "Famvir 125 mg tablet",
"unit": "tablet"
},
{
"cost": "7.16",
"description": "Famvir 250 mg tablet",
"unit": "tablet"
},
{
"cost": "11.67",
"description": "Famciclovir 500 mg tablet",
"unit": "tablet"
},
{
"cost": "14.39",
"description": "Famvir 500 mg tablet",
"unit": "tablet"
}
] |
[
{
"approved": "1993-09-21",
"country": "United States",
"expires": "2010-09-21",
"number": "5246937"
},
{
"approved": "2005-11-08",
"country": "Canada",
"expires": "2014-11-11",
"number": "2176392"
},
{
"approved": "2003-04-08",
"country": "Canada",
"expires": "2011-07-03",
"number": "2086756"
},
{
"approved": "1998-11-24",
"country": "United States",
"expires": "2016-03-01",
"number": "5840763"
},
{
"approved": "1999-06-29",
"country": "United States",
"expires": "2016-03-01",
"number": "5916893"
}
] |
2-(2-(2-amino-9H-purin-9-yl)ethyl)-1,3-propanediol diacetate | 9-[4-acetoxy-3-(acetoxymethyl)but-1-yl]-2-aminopurine | acetic acid 2-acetoxymethyl-4-(2-amino-purin-9-yl)-butyl ester | Famciclovir | Famciclovirum | FCV | 2.7.7.7 | 1.2.3.1 | Aldehyde oxidase 1 | AO | Azaheterocycle hydroxylase
|
[
"Act Famciclovir",
"Act Famciclovir",
"Act Famciclovir",
"Apo-famciclovir",
"Apo-famciclovir",
"Apo-famciclovir",
"Auro-famciclovir",
"Auro-famciclovir",
"Auro-famciclovir",
"Ava-famciclovir",
"Ava-famciclovir",
"Ava-famciclovir",
"Dom-famciclovir",
"Dom-famciclovir",
"Dom-famciclovir",
"Famciclovir",
"Famciclovir",
"Famciclovir",
"Famciclovir",
"Famciclovir",
"Famciclovir",
"Famciclovir",
"Famciclovir",
"Famciclovir",
"Famciclovir",
"Famciclovir",
"Famciclovir",
"Famciclovir",
"Famciclovir",
"Famciclovir",
"Famciclovir",
"Famciclovir",
"Famciclovir",
"Famciclovir",
"Famciclovir",
"Famciclovir",
"Famciclovir",
"Famciclovir",
"Famciclovir",
"Famciclovir",
"Famciclovir",
"Famciclovir",
"Famciclovir",
"Famciclovir",
"Famciclovir",
"Famciclovir",
"Famciclovir",
"Famciclovir",
"Famciclovir",
"Famciclovir",
"Famciclovir",
"Famciclovir",
"Famciclovir",
"Famciclovir",
"Famciclovir",
"Famciclovir",
"Famciclovir",
"Famciclovir",
"Famciclovir",
"Famciclovir",
"Famciclovir",
"Famciclovir",
"Famciclovir",
"Famciclovir",
"Famciclovir",
"Famciclovir",
"Famciclovir",
"Famciclovir",
"Famciclovir",
"Famciclovir",
"Famciclovir",
"Famciclovir",
"Famciclovir",
"Famciclovir",
"Famciclovir",
"Famciclovir",
"Famciclovir",
"Famciclovir",
"Famciclovir",
"Famciclovir",
"Famciclovir",
"Famciclovir",
"Famciclovir",
"Famciclovir",
"Famciclovir",
"Famciclovir",
"Famciclovir",
"Famciclovir",
"Famciclovir",
"Famciclovir",
"Famciclovir",
"Famciclovir",
"Famciclovir",
"Famvir",
"Famvir",
"Famvir",
"Famvir",
"Famvir",
"Famvir",
"Famvir",
"Famvir",
"Famvir",
"Novo-famciclovir",
"Novo-famciclovir",
"Novo-famciclovir",
"PHL-famciclovir",
"PHL-famciclovir",
"PHL-famciclovir",
"PMS-famciclovir",
"PMS-famciclovir",
"PMS-famciclovir",
"Sandoz Famciclovir",
"Sandoz Famciclovir",
"Sandoz Famciclovir"
] |
[
"Ezovir",
"Fambir",
"Famcino",
"Famcir",
"Famvir Once",
"Fanclomax",
"Fanle",
"Microvir",
"Oravir",
"Pentavir",
"Penvir",
"Pixin",
"Virovir",
"Wan Qi",
"Weike"
] |
[] |
[] |
[
"Q06278"
] |
[] |
[] |
DB00427
|
Triprolidine
|
First generation histamine H1 antagonist used in allergic rhinitis; asthma; and urticaria. It is a component of cough and cold medicines. It may cause drowsiness.
|
solid
|
For the symptomatic relief of seasonal or perennial allergic rhinitis or nonallergic rhinitis; allergic conjunctivitis; and mild, uncomplicated allergic skin manifestations of urticaria and angioedema. Also used in combination with other agents for the symptomatic relief of symptoms associated with the common cold.
|
In allergic reactions an allergen interacts with and cross-links surface IgE antibodies on mast cells and basophils. Once the mast cell-antibody-antigen complex is formed, a complex series of events occurs that eventually leads to cell-degranulation and the release of histamine (and other chemical mediators) from the mast cell or basophil. Once released, histamine can react with local or widespread tissues through histamine receptors. Histamine, acting on H1-receptors, produces pruritis, vasodilatation, hypotension, flushing, headache, tachycardia, and bronchoconstriction. Histamine also increases vascular permeability and potentiates pain. Triprolidine, is a histamine H1 antagonist that competes with histamine for the normal H1-receptor sites on effector cells of the gastrointestinal tract, blood vessels and respiratory tract. It provides effective, temporary relief of sneezing, watery and itchy eyes, and runny nose due to hay fever and other upper respiratory allergies. Triprolidine has anticholinergic and sedative effects.
|
Triprolidine binds to the histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine.
|
Rapidly absorbed in the intestinal tract.
| null |
Symptoms of overdose include drowsiness, weakness, inco-ordination, difficulty with micturition, respiratory depression, hypotension, agitation, irritability, convulsions, hypertension, palpitation and tachycardia.
|
4 to 6 hours.
| null | null | null | null |
Organic compounds
|
Benzenoids
|
Benzene and substituted derivatives
|
Styrenes
|
[
"approved"
] |
[
"R06AX",
"R06A",
"R06",
"R"
] |
[
"Humans and other mammals"
] |
[
{
"cost": "40.33",
"description": "Triprolidine hcl crystals",
"unit": "g"
},
{
"cost": "0.14",
"description": "Tripohist 1.25 mg/5 ml liquid",
"unit": "ml"
},
{
"cost": "0.15",
"description": "Triprolidine 1.25 mg/5 ml liq",
"unit": "ml"
}
] |
[] |
(E)-2-[3-(1-pyrrolidinyl)-1-p-toluenepropenyl]pyridine | trans-1-(2-pyridyl)-3-pyrrolidino-1-p-tolylprop-1-ene | trans-1-(4-methylphenyl)-1-(2-pyridyl)-3-pyrrolidinoprop-1-ene | Tripolidina | Triprolidin | Triprolidina | Triprolidine | Triprolidinum | H1-R | H1R | HH1R
|
[
"Actifed DM Syrup",
"Actifed DM Syrup",
"Actifed DM Tablets",
"Actifed DM Tablets",
"Actifed Plus Caplet",
"Actifed Plus Caplets",
"Actifed Syrup",
"Actifed Tablets",
"Actifed Tablets",
"Allerdine",
"Aprodine",
"Aprodine",
"Aprodine",
"Aprodine",
"Aprodine",
"Aprodine",
"Childrens PediaClear Allergy",
"Childrens PediaClear PD",
"Coactifed",
"Coactifed",
"Coactifed",
"Colcol Co Tab.",
"Cold and Allergy D",
"Cold and Allergy D",
"Cold and Flu Daytime Nighttime",
"Cold and Flu Nighttime",
"Coldifed Syrup",
"Cotrifed",
"Covan Syrup",
"CVS Maximum Strength Severe Congestion and Cough Overnight Cold and Flu Clear and cool",
"CVS Mucus Relief DM and Overnight Cold and Flu",
"CVS Nighttime Cold and Flu",
"CVS Overnight Cold and Flu Clear and Cool",
"Delsym Nighttime Cough",
"Dr Manzanilla DM",
"Dr Manzanilla Infant",
"Dr Manzanilla PE",
"Dr Manzanilla Pediatric",
"Ed-A-hist Pse",
"Endal",
"FLONASE Nighttime Allergy Relief",
"Hist-PSE",
"Histex",
"Histex",
"Histex Ac",
"HISTEX PD Drops",
"HISTEX PDX Drops",
"Histex-DM",
"Histex-PE",
"M-Hist PD",
"Maxi-Tuss TR",
"Maxifed TR",
"Maximum Strength Mucinex Fast-Max Cold and Flu and Mucinex NightShift Severe Cold and Flu",
"Maximum Strength Mucinex Fast-Max Cold and Flu and Mucinex NightShift Severe Cold and Flu",
"Maximum Strength Mucinex Sinus-Max Severe Congestion and Pain and Mucinex Nightshift Sinus",
"Meijer Nighttime Cold and Flu",
"Miclara DM",
"Miclara LQ",
"Mucinex Childrens FreeFrom Multi-Symptom Cold and Flu Nighttime",
"Mucinex Childrens FreeFrom Multi-Symptom Cold, Flu and Sore Throat and Mucinex Childrens FreeFrom Multi-Symptom Cold and Flu Nighttime",
"Mucinex Childrens FreeFrom Multi-Symptom Cold, Flu and Sore Throat and Mucinex Childrens FreeFrom Multi-Symptom Cold and Flu Nighttime",
"MUCINEX FAST MAX Liquid Cold and Flu Kickstart and MUCINEX Nightshift Kickstart",
"Mucinex Fast-Max Cold and Flu and Mucinex NightShift Cold and Flu",
"Mucinex Fast-Max Cold and Flu Arctic Burst and Nightshift Severe Cold and Flu Arctic Burst",
"Mucinex Fast-Max Cold, Flu and Sore Throat and Mucinex NightShift Cold and Flu",
"Mucinex Fast-Max Day Cold and Flu and Mucinex Nightshift Night Severe Cold and Flu Maximum Strength",
"Mucinex Fast-Max Day Severe Congestion and Cough and Mucinex Nightshift Night Cold and Flu Maximum Strength",
"Mucinex Fast-Max DM Max and Mucinex Nightshift Cold and Flu",
"Mucinex Fast-Max Severe Congestion and Cough and Mucinex Nightshift Cold and Flu",
"Mucinex Fast-Max Severe Congestion and Cough Clear and Cool and Maximum Strength Mucinex Nightshift Cold and Flu Clear and Cool",
"Mucinex FreeFrom Cold and Flu Daytime and Mucinex FreeFrom Cold and Flu Nighttime",
"Mucinex FreeFrom Cold and Flu Nighttime",
"Mucinex Night Time Severe Cold and Flu",
"Mucinex Nightshift Cold and Flu",
"Mucinex Nightshift Cold and Flu Clear and Cool",
"Mucinex Nightshift Cold and Flu Maximum Strength",
"Mucinex Nightshift Severe Cold and Flu",
"Mucinex Nightshift Severe Cold and Flu Arctic Burst",
"Mucinex Nightshift Severe Cold and Flu Maximum Strength",
"Mucinex Nightshift Sinus",
"Mucinex Nightshift Sinus Clear and Cool",
"Mucinex Nightshift Sinus Maximum Strength",
"Mucinex Sinus-Max Day Pressure, Pain and Cough and Mucinex Nightshift Night Sinus Maximum Strength",
"Mucinex-Sinus Max Severe Congestion and Pain Clear and Cool and Mucinex Nightshift Sinus Clear and Cool",
"Mucus DM Fast Max Day Cold and Flu and Night Cold and Flu",
"Mucus Fast Max Day Cold and Flu and Night Cold and Flu",
"Mucus Relief DM and Overnight Cold and Flu",
"Overnight Cold and Flu",
"Overnight Cold and Flu",
"Pediatex TD",
"Pediatex TDM",
"Poly Hist NC",
"Pseudodine C",
"Severe Congestion and Cough, Cold and Flu Daytime, Nighttime",
"Severe Congestion, Cough, Cold and Flu Relief Maximum Strength, Nighttime",
"Silafed",
"Stahist Tp",
"Target Maximum Strength Cold Flu and Sore Throat Overnight Cold and Flu",
"Target Overnight Cold and Flu",
"Teva-cotridin",
"Teva-cotridin Expectorant",
"Triacin-C",
"Triacin-C",
"Trip-pse",
"Tripohist",
"Tripohist D",
"Triponel",
"Triponel",
"Triprofed Tab",
"Triprolidine HCl Drops",
"Triprolidine HCl Drops",
"Triprolidine HCl PSE HCl",
"Triprolidine Hydrochloride",
"Triprolidine Hydrochloride",
"Triprolidine Hydrochloride",
"Triprolidine Hydrochloride",
"Triprolidine Hydrochloride",
"Triprolidine Hydrochloride",
"Triprolidine Hydrochloride",
"Triprolidine Hydrochloride",
"VanaClear PD",
"Vanahist Pd",
"Wal-Act",
"Whituben"
] |
[
"Anmin",
"Venen"
] |
[
"Pseudodine C",
"Tripohist D",
"Triprolidine HCl PSE HCl",
"Aprodine",
"Trip-pse",
"Pediatex TD",
"Hist-PSE",
"Pediatex TDM",
"Triacin-C",
"Aprodine",
"Triacin-C",
"Aprodine",
"Silafed",
"Poly Hist NC",
"Triponel",
"Colcol Co Tab.",
"Whituben",
"Mucinex Nightshift Cold and Flu",
"Mucinex Nightshift Cold and Flu Clear and Cool",
"Mucinex Nightshift Sinus",
"Mucinex Nightshift Sinus Clear and Cool",
"Histex Ac",
"Aprodine",
"Wal-Act",
"Aprodine",
"Triponel",
"Histex-DM",
"Overnight Cold and Flu",
"CVS Maximum Strength Severe Congestion and Cough Overnight Cold and Flu Clear and cool",
"Mucus Relief DM and Overnight Cold and Flu",
"Stahist Tp",
"Mucinex Nightshift Severe Cold and Flu",
"Target Maximum Strength Cold Flu and Sore Throat Overnight Cold and Flu",
"Target Overnight Cold and Flu",
"Mucinex Childrens FreeFrom Multi-Symptom Cold and Flu Nighttime",
"Mucinex FreeFrom Cold and Flu Nighttime",
"CVS Mucus Relief DM and Overnight Cold and Flu",
"CVS Overnight Cold and Flu Clear and Cool",
"CVS Nighttime Cold and Flu",
"Meijer Nighttime Cold and Flu",
"Histex-PE",
"Dr Manzanilla PE",
"Dr Manzanilla DM",
"Ed-A-hist Pse",
"Mucinex Childrens FreeFrom Multi-Symptom Cold, Flu and Sore Throat and Mucinex Childrens FreeFrom Multi-Symptom Cold and Flu Nighttime",
"Mucinex FreeFrom Cold and Flu Daytime and Mucinex FreeFrom Cold and Flu Nighttime",
"Delsym Nighttime Cough",
"Mucinex Childrens FreeFrom Multi-Symptom Cold, Flu and Sore Throat and Mucinex Childrens FreeFrom Multi-Symptom Cold and Flu Nighttime",
"Maxifed TR",
"Maxi-Tuss TR",
"Miclara DM",
"Mucinex Nightshift Sinus Maximum Strength",
"Mucinex Nightshift Severe Cold and Flu Maximum Strength",
"Mucinex Fast-Max Day Severe Congestion and Cough and Mucinex Nightshift Night Cold and Flu Maximum Strength",
"Mucinex Sinus-Max Day Pressure, Pain and Cough and Mucinex Nightshift Night Sinus Maximum Strength",
"Mucinex Nightshift Cold and Flu Maximum Strength",
"Mucinex Fast-Max Day Cold and Flu and Mucinex Nightshift Night Severe Cold and Flu Maximum Strength",
"Mucinex Nightshift Severe Cold and Flu Arctic Burst",
"Coactifed",
"Actifed Plus Caplet",
"Actifed DM Tablets",
"Triprofed Tab",
"Actifed DM Syrup",
"Actifed Tablets",
"Actifed Syrup",
"Coactifed",
"Coactifed",
"Actifed Tablets",
"Actifed Plus Caplets",
"Cotrifed",
"Covan Syrup",
"Actifed DM Syrup",
"Actifed DM Tablets",
"Teva-cotridin Expectorant",
"Teva-cotridin",
"Coldifed Syrup",
"Cold and Allergy D",
"Cold and Flu Nighttime",
"Cold and Flu Daytime Nighttime",
"Severe Congestion, Cough, Cold and Flu Relief Maximum Strength, Nighttime",
"Maximum Strength Mucinex Sinus-Max Severe Congestion and Pain and Mucinex Nightshift Sinus",
"Maximum Strength Mucinex Fast-Max Cold and Flu and Mucinex NightShift Severe Cold and Flu",
"Mucinex Fast-Max DM Max and Mucinex Nightshift Cold and Flu",
"Mucinex Fast-Max Severe Congestion and Cough and Mucinex Nightshift Cold and Flu",
"Mucinex Fast-Max Cold, Flu and Sore Throat and Mucinex NightShift Cold and Flu",
"Mucinex Fast-Max Cold and Flu and Mucinex NightShift Cold and Flu",
"Maximum Strength Mucinex Fast-Max Cold and Flu and Mucinex NightShift Severe Cold and Flu",
"Cold and Allergy D",
"Aprodine",
"Mucinex Fast-Max Severe Congestion and Cough Clear and Cool and Maximum Strength Mucinex Nightshift Cold and Flu Clear and Cool",
"Severe Congestion and Cough, Cold and Flu Daytime, Nighttime",
"Mucinex-Sinus Max Severe Congestion and Pain Clear and Cool and Mucinex Nightshift Sinus Clear and Cool",
"Overnight Cold and Flu",
"Endal",
"Mucinex Night Time Severe Cold and Flu",
"MUCINEX FAST MAX Liquid Cold and Flu Kickstart and MUCINEX Nightshift Kickstart",
"Mucus DM Fast Max Day Cold and Flu and Night Cold and Flu",
"Mucinex Fast-Max Cold and Flu Arctic Burst and Nightshift Severe Cold and Flu Arctic Burst",
"Mucus Fast Max Day Cold and Flu and Night Cold and Flu"
] |
[
"P35367"
] |
[] |
[
"P02768"
] |
[] |
DB00428
|
Streptozocin
|
An antibiotic that is produced by Stretomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
|
solid
|
For the treatment of malignant neoplasms of pancreas (metastatic islet cell carcinoma).
|
Streptozocin is an antitumour antibiotic consisting of a nitrosourea moiety interposed between a methyl group and a glucosamine. Streptozocin is indicated in the treatment of metastatic islet cell carcinoma of the pancreas. Streptozocin inhibits DNA synthesis in bacterial and mammalian cells. In bacterial cells, a specific interaction with cytosine moieties leads to degradation of DNA. The biochemical mechanism leading to mammalian cell death has not been definitely established; streptozocin inhibits cell proliferation at a considerably lower level than that needed to inhibit precursor incorporation into DNA or to inhibit several of the enzymes involved in DNA synthesis. Although streptozocin inhibits the progression of cells into mitosis, no specific phase of the cell cycle is particularly sensitive to its lethal effects.
|
Although its mechanism of action is not completely clear, streptozocin is known to inhibit DNA synthesis, interfere with biochemical reactions of NAD and NADH, and inhibit some enzymes involved in gluconeogenesis. Its activity appears to occur as a result of formation of methylcarbonium ions, which alkylate or bind with many intracellular molecular structures including nucleic acids. Its cytotoxic action is probably due to cross-linking of strands of DNA, resulting in inhibition of DNA synthesis.
|
Poor oral absorption (17-25%)
|
Primarily hepatic
|
Symptoms of overdose include nausea and vomiting, anorexia, myelosuppression; and nephrotoxicity.
|
5-15 minutes
| null |
As much as 20% of the drug (or metabolites containing an N-nitrosourea group) is metabolized and/or excreted by the kidney.
| null | null | null | null | null | null |
[
"approved",
"investigational"
] |
[
"L01AD",
"L01A",
"L01",
"L"
] |
[
"Humans and other mammals"
] |
[
{
"cost": "78.82",
"description": "Zanosar 1 gm powder vial",
"unit": "vial"
}
] |
[] |
1-METHYL-1-NITROSO-3-((2R,3R,4S,5R)-3,4,5,6-TETRAHYDROXY-1-OXOHEXAN-2-YL)UREA | 1-METHYL-1-NITROSO-3-((3R,4R,5S,6R)-2,4,5-TRIHYDROXY-6-(HYDROXYMETHYL)TETRAHYDRO-2H-PYRAN-3-YL)UREA | 2-Deoxy-2-(((methylnitrosoamino)carbonyl)amino)-D-glucopyranose | 2-Deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose | D-GLUCOPYRANOSE, 2-DEOXY-2-(((METHYLNITROSOAMINO)CARBONYL)AMINO)- | Estreptozocina | N-D-Glucosyl-(2)-N'-nitrosomethylharnstoff | N-D-Glucosyl-(2)-N'-nitrosomethylurea | Streptozocin | Streptozocine | Streptozocinium | Streptozocinum | Streptozotocin | 3.2.1.169 | Beta-hexosaminidase | Beta-N-acetylglucosaminidase | Beta-N-acetylhexosaminidase | Hexosaminidase B | N-acetyl-beta-glucosaminidase | Glucose transporter type 2, liver | GLUT-2 | GLUT2 | 3.2.1.169 | Beta-hexosaminidase | Beta-N-acetylglucosaminidase | Beta-N-acetylhexosaminidase | HEXC | KIAA0679 | MEA5 | Meningioma-expressed antigen 5 | MGEA5 | N-acetyl-beta-D-glucosaminidase | N-acetyl-beta-glucosaminidase | NCOAT | Nuclear cytoplasmic O-GlcNAcase and acetyltransferase | OGA | 1.14.14.1 | CYPIA1 | Cytochrome P450 form 6 | Cytochrome P450-C | Cytochrome P450-P1 | Hydroperoxy icosatetraenoate dehydratase | 1.14.14.1 | Cholesterol 25-hydroxylase | CYPIA2 | Cytochrome P(3)450 | Cytochrome P450 4 | Cytochrome P450-P3 | Hydroperoxy icosatetraenoate dehydratase | 1.14.14.1 | 4-nitrophenol 2-hydroxylase | CYP2E | CYPIIE1 | Cytochrome P450-J | ATP-binding cassette sub-family B member 1 | MDR1 | Multidrug resistance protein 1 | P-glycoprotein 1 | PGY1 | Phospholipid transporter ABCB1
|
[
"Zanosar",
"Zanosar",
"Zanosar Sterile Powder"
] |
[] |
[] |
[
"P11168",
"O60502"
] |
[
"P04798",
"P05177",
"P05181"
] |
[] |
[
"P08183"
] |
DB00429
|
Carboprost tromethamine
|
A nonsteroidal abortifacient agent that is effective in both the first and second trimesters of pregnancy.
|
solid
|
For aborting pregnancy between the 13th and 20th weeks of gestation as calculated from the first day of the last normal menstrual period and in the following conditions related to second trimester abortion: 1. Failure of expulsion of the fetus during the course of treatment by another method; 2. Premature rupture of membranes in intrauterine methods with loss of drug and insufficient or absent uterine activity; 3. Requirement of a repeat intrauterine instillation of drug for expulsion of the fetus; 4. Inadvertent or spontaneous rupture of membranes in the presence of a previable fetus and absence of adequate activity for expulsion. Also for the treatment of postpartum hemorrhage due to uterine atony which has not responded to conventional methods of management.
|
Carboprost tromethamine administered intramuscularly stimulates in the gravid uterus myometrial contractions similar to labor contractions at the end of a full term pregnancy. Whether or not these contractions result from a direct effect of carboprost on the myome-trium has not been determined. Nonetheless, they evacuate the products of conception from the uterus in most cases. Postpartum, the resultant myometrial contractions provide hemostasis at the site of placentation. Carboprost tromethamine also stimulates the smooth muscle of the human gastrointestinal tract. This activity may produce the vomiting or diarrhea or both that is common when carbo-prost tromethamine is used to terminate pregnancy and for use postpartum. In laboratory animals and also in humans carboprost tromethamine can elevate body temperature. With the clinical doses of carboprost trometh-amine used for the termination of pregnancy, and for use postpartum, some patients do experience transient temperature increases. In laboratory animals and in humans large doses of carboprost tromethamine can raise blood pressure, probably by contracting the vascular smooth muscle. With the doses of carboprost tromethamine used for terminating pregnancy, this effect has not been clinically significant. In laboratory animals and also in humans carboprost tromethamine can elevate body temperature. With the clinical doses of carboprost tromethamine used for the termination of pregnancy, some patients do experience temperature increases. In some patients, carboprost tromethamine may cause transient bronchoconstriction.
|
Carboprost is a synthetic prostaglandin. It binds the prostaglandin E2 receptor, causing myometrial contractions, casuing the induction of labour or the expulsion of the placenta. Prostaglandins occur naturally in the body and act at several sites in the body including the womb (uterus). They act on the muscles of the womb, causing them to contract.
| null |
Metabolized in the lungs and liver. Metabolites are excreted in urine.
|
Symptoms of overdose include irritation, nausea, vomiting, diarrhea, coughing, dyspnea, asthma, hypertension, flushing, and pyrexia.
| null | null | null | null | null | null | null | null | null |
[
"approved"
] |
[] |
[
"Humans and other mammals"
] |
[
{
"cost": "92.89",
"description": "Hemabate 250 mcg/ml ampul",
"unit": "ml"
},
{
"cost": "0.49",
"description": "Tham iv solution",
"unit": "ml"
}
] |
[] |
(15S)-15-methyl-PGF2α tromethamine salt | (15S)-15-methylprostaglandin F2α tromethamine | 1,3-dihydroxy-2-(hydroxymethyl)propan-2-aminium (5Z,9α,11β,13E,15S)-9,11,15-trihydroxy-15-methylprosta-5,13-dien-1-oate | 15(S)-15-methyl-PGF2α tromethamine salt | 15(S)-15-methylprostaglandin F2α tromethamine | Carboprost trometamol | Carboprost tromethamine | PGE receptor EP1 subtype | PGE2 receptor EP1 subtype | Prostanoid EP1 receptor | PGF receptor | PGF2-alpha receptor | Prostanoid FP receptor
|
[
"Carboprost Tromethamine",
"Carboprost Tromethamine",
"Carboprost Tromethamine",
"Carboprost Tromethamine",
"Carboprost Tromethamine",
"Carboprost Tromethamine",
"Carboprost Tromethamine",
"Carboprost Tromethamine",
"Carboprost Tromethamine",
"Carboprost Tromethamine",
"Carboprost Tromethamine",
"Carboprost Tromethamine",
"Carboprost Tromethamine",
"Carboprost Tromethamine",
"Carboprost Tromethamine",
"Carboprost Tromethamine",
"Carboprost Tromethamine",
"Carboprost Tromethamine",
"Carboprost Tromethamine",
"Carboprost Tromethamine",
"Carboprost Tromethamine Injection",
"Carboprost Tromethamine Injection USP",
"Carboprost Tromethamine Injection, USP",
"Hemabate",
"Hemabate"
] |
[
"Carboprost",
"Deviprost",
"Prostin 15M",
"Prostinfenem",
"Prostodin"
] |
[] |
[
"P34995",
"P43088"
] |
[] |
[] |
[] |
DB00430
|
Cefpiramide
|
Cefpiramide is a third-generation cephalosporin antibiotic.
|
solid
|
For treatment of severe infections caused by susceptible bacteria such as P. aeruginosa.
|
Cefpiramide is a cephalosporin active against <i>Pseudomonas aeruginosa</i>. It has a broad spectrum of antibacterial activity. Cefpiramide works by inhibiting bacterial cell wall biosynthesis. The plasma half-lives of cefpiramide in rabbits, dogs, and rhesus monkeys were much longer than those of cefoperazone and cefazolin.
|
The bactericidal activity of cefpiramide results from the inhibition of cell wall synthesis via affinity for penicillin-binding proteins (PBPs).
|
Rapidly absorbed following intramuscular injection.
| null |
Adverse effects following overdosage include nausea, vomiting, epigastric distress, diarrhea, and convulsions.
|
4.44 hours
| null | null | null | null |
Organic compounds
|
Organic acids and derivatives
|
Carboxylic acids and derivatives
|
Amino acids, peptides, and analogues
|
[
"approved"
] |
[
"J01DD",
"J01D",
"J01",
"J"
] |
[
"Enteric bacteria and other eubacteria"
] |
[] |
[] |
Cefpiramide | Cefpiramido | Cefpiramidum | 2.4.1.129 | PBP-3 | pbpB | Penicillin-binding protein 3 | Peptidoglycan glycosyltransferase 3 | Murein polymerase | PBP-1b | pbpF | ponB | PBP-1a | ponA | mrcB | Murein polymerase | PBP-1b | 3.4.16.4 | DD-carboxypeptidase | PBP-6 | Penicillin-binding protein 6 | PBP-1a | ponA
|
[] |
[] |
[] |
[] |
[] |
[
"P02768"
] |
[] |
DB00431
|
Lindane
|
An organochlorine insecticide that has been used as a pediculicide and a scabicide. Lindane has been banned in California, United Kingdom, Australia, and many western countries due to concerns about neurotoxicity and adverse effects on the environment. In Canada, Lindane is not recommmended as a first-line therapy due to reports of resistance, neurotoxicity, and bone marrow suppression, but has been approved by the FDA as a second-line therapy for topical treatment of pediculosis capitis (head lice), pediculosis pubis (pubic lice), or scabies in patients greater than two years of age who cannot tolerate or have failed first-line treatment. Lindane is still allowed for pharmaceutical use until 2015.
|
liquid
|
For the treatment of patients infested with Sarcoptes scabiei or pediculosis capitis who have either failed to respond to adequate doses, or are intolerant of other approved therapies.
|
Scabies is a common, highly pruritic infestation of the skin caused by Sarcoptes scabiei (lice). It is a very contagious condition with specific lesions, such as burrows, and nonspecific lesions, such as papules, vesicles and excoriations. The typical areas of the body it affects are finger webs, scalp (hair), wrists, axillary folds, abdomen, buttocks, inframammary folds and genitalia (males). It is characterized by intense night-time itching. Scabies is spread through close personal contact (relatives, sexual partners, schoolchildren, chronically ill patients and crowded communities). Scabies infestations and the corresponding symptoms can be eliminated by killing the scabies with topical insecticides or scabicides. Lindane is a scabicide that is essentially an organochloride insecticide.
|
Lindane is an organochloride insecticide that has similar neurotoxic protperties to DDT. It exerts its parasiticidal action by being directly absorbed through the parasite's exoskeleton (primarily lice, or scabies) and their ova. The gamma-aminobutyric acid (GABA(1)) receptor/chloride ionophore complex is the primary site of action for lindane, and other insecticides such as endosulfan, and fipronil. Blockage of the GABA-gated chloride channel reduces neuronal inhibition, which leads to hyperexcitation of the central nervous system. This results in paralysis, convulsions, and death. Lindane has very low ovicidal activity.
|
Lindane is absorbed significantly through the skin. A mean peak blood concentration of 28 nanograms per mL occurred in infants and children 6 hours after total body application of lindane lotion for scabies.
|
Primarily hepatic through dechlorination leading to 2-chlorophenol, 0-chlorophenol, chlorocyclohexane, chlorocyclohexanol.
|
Lindane is a moderately toxic compound via oral exposure, with a reported oral LD<sub>50</sub> of 88 to 190 mg/kg in rats. Gamma-HCH (which constitutes 99% of lindane) is generally considered to be the most acutely toxic of the isomers following single administration. It is moderately toxic via the dermal route as well, with reported dermal LD<sub>50</sub> values of 500 to 1000 mg/kg in rats, 300 mg/kg in mice, 400 mg/kg in guinea pigs, and 300 mg/kg in rabbits. Acute exposure to lindane may lead to central nervous system stimulation (usually developing within 1 hour), mental/motor impairment, excitation, clonic (intermittent) and tonic (continuous) convulsion. Other adverse reactions include central nervous system toxicity, as well as skin and gastrointestinal changes.
|
18 hours
|
91%
| null | null | null |
Organic compounds
|
Organohalogen compounds
|
Alkyl halides
|
Cyclohexyl halides
|
[
"approved",
"withdrawn"
] |
[
"P03AB",
"P03A",
"P03",
"P"
] |
[
"Scabies (Sarcoptes scabei) and other insects"
] |
[
{
"cost": "5.16",
"description": "Lindane 1% lotion",
"unit": "ml"
},
{
"cost": "142.33",
"description": "Lindane 1% Lotion 60ml Bottle",
"unit": "bottle"
},
{
"cost": "142.33",
"description": "Lindane 1% Shampoo 60ml Bottle",
"unit": "bottle"
}
] |
[] |
(1r,2c,3t,4c,5c,6t)-1,2,3,4,5,6-hexachlorocyclohexane | (1α,2α,3β,4α,5α,6β)-1,2,3,4,5,6-hexachlorocyclohexane | 1,2,3,4,5,6-hexachlorocyclohexane | Benzene hexachloride | gamma-1,2,3,4,5,6-hexachlorocyclohexane | gamma-benzene hexachloride | gamma-BHC | gamma-HCH | gamma-Hexachlorocyclohexane | gamma-Lindane | Gammallin | Gammaxene | Lindan | Lindane | Lindano | Lindanum | γ-hexachlorocyclohexane | γ-Hexachlorzyklohexan | γ-lindane | GABA(A) receptor subunit beta-1 | GABAAR subunit beta-1 | Glycine receptor 48 kDa subunit | Glycine receptor strychnine-binding subunit | Glycine receptor 58 kDa subunit | GABA(A) receptor subunit beta-3 | GABAAR subunit beta-3 | GABA(A) receptor subunit rho-1 | GABA(C) receptor | GABAAR subunit rho-1 | NR3C3 | Nuclear receptor subfamily 3 group C member 3 | PR | ER | ER-alpha | ESR | Estradiol receptor | NR3A1 | Nuclear receptor subfamily 3 group A member 1 | Orphan nuclear receptor PAR1 | Orphan nuclear receptor PXR | Pregnane X receptor | PXR | Steroid and xenobiotic receptor | SXR
|
[
"Dom-lindane Lotion - 1%",
"Hexit Lotion",
"Hexit Shampoo 1.0%",
"Kwellada Lotion 1%",
"Kwellada Shampoo 1%",
"Lindane",
"Lindane",
"Lindane",
"Lindane",
"Lindane",
"Lindane",
"Lindane",
"Lindane",
"Lindane Lotion USP 1%",
"Lindane Shampoo USP 1%",
"PMS-lindane Lot 1%",
"PMS-lindane Shp 1%"
] |
[
"Gamene",
"Kwell",
"Scabene"
] |
[] |
[
"P18505",
"P23415",
"P23416",
"O75311",
"P48167",
"P28472",
"P24046",
"P06401",
"P03372",
"O75469"
] |
[] |
[] |
[] |
DB00432
|
Trifluridine
|
Trifluridine is a fluorinated pyrimidine nucleoside that is structurally related to [idoxuridine] [A35271]. It is an active antiviral agent in ophthalmic solutions used mainly in the treatment of primary keratoconjunctivitis and recurrent epithelial keratitis due to herpes simplex virus. It displays effective antiviral activity against Herpes simplex virus type 1 and 2 [A35271].
The combination product of trifluridine with tipiracil marketed as Lonsurf has been approved in Japan, the United States, and the European Union for the treatment of adult patients with metastatic colorectal cancer who have been previously treated with fluoropyrimidine-, oxaliplatin- and irinotecan-based chemotherapy, an anti-VEGF biological therapy, and if RAS wild-type, an anti-EGFR therapy. In the anticancer therapy, trifluridine acts as a thymidine-based nucleoside metabolic inhibitor that gets incorporated into DNA of cancer cells following cell uptake to aberrate DNA function during cell replication [F649].
|
solid
|
As a standalone product, trifluridine is used for the ophthalmic treatment of primay keratoconjunctivitis and recurrent epithelial keratitis due to herpes simplex virus, types 1 and 2.[L47671]
Trifluridine is also available as a combination product with [tipiracil], which is indicated either alone or in combination with [bevacizumab] for the treatment of adult patients with metastatic colorectal cancer who have been previously treated with fluoropyrimidine-, oxaliplatin- and irinotecan-based chemotherapy, an anti-VEGF biological therapy, and if RAS wild-type, an anti-EGFR therapy.[L47676] This combination product is also used for adult patients with metastatic gastric or gastroesophageal junction adenocarcinoma and were previously treated with at least two prior lines of chemotherapy that included a fluoropyrimidine, a platinum, either a taxane or irinotecan, and if appropriate, HER2/neu-targeted therapy.[L47676]
|
Trifluridine exhibits an antiviral effect against herpes simplex virus, types 1 and 2 and vacciniavirus both in vitro and in vivo [A35271]. Some strains of adenovirus that contribute to the pathology of keratoconjunctivitis were shown to be susceptible to trifluridine _in vitro_ [A35271]. While there is evidence from a study that cross-resistance may develop between trifluridine and [idoxuridine] or [vidarabine], trifluridine was shown to effective in treating dendritic ulcers in patients with herpetic keratitis who are unresponsive to [idoxuridine] or [vidarabine] based on the results from masked comparative trials [A35271]. In nonclinical studies, trifluridine/tipiracil hydrochloride demonstrated antitumour activity against both 5-fluorouracil (5-FU) sensitive and resistant colorectal cancer cell lines [F649]. The cytotoxic activity of trifluridine and tipiracil against several human tumour xenografts show high correlation with the amount of trifluridine incorporated into DNA, indicating that the primary mechanism of action of trifluridine involves the direct incorporation into the cancer cell DNA [F649]. Trifluridine and tipiracil demonstrated anti-tumor activity against KRAS wild-type and mutant human colorectal cancer xenografts in mice [FDA Label].
In clinical studies comprised of patients with previously treated metastatic colorectal cancer, treatment of trifluridine in combination with tipiracil in addition to best supportive care over a 5- or 7-month period resulted in increased progression-free survival (PFS), overall response rate (ORR) and disease control rate (DCR) compared to placebo [F649]. In an open-label study, administration of trifluridine at the recommended dosage in patients with advanced solid tumors had no clinically relevant effect on QT/QTc prolongation compared with placebo [FDA Label]. Two out of 48 patients displayed had QTc greater than 500 msec and 1 of 42 patients (2.4%) had a QTc increase from baseline greater than 60 msec [FDA Label].
|
The mechanism of action of trifluridine as an antiviral agent has not been fully elucidated, but appears to involve the inhibition of viral replication. Trifluridine gets incorporated into viral DNA during replication, which leads to the formation of defective proteins and an increased mutation rate. Trifluridine also mediates antineoplastic activities via this mechanism; following uptake into cancer cells, trifluridine is rapidly phosphorylated by thymidine kinase to its active monophosphate form [A35272]. Subsequent phosphorylation produces trifluridine triphosphate [A35272], which is readily incorporated into the DNA of tumour cells in place of thymidine bases to perturb DNA function, DNA synthesis, and tumour cell proliferation [FDA Label]. As trifluridine is subject to rapid degradation by TPase and readily metabolised by a first-pass effect following oral administration, tipiracil is added in the antineoplastic combination product as an inhibitor of TPase to increase the bioavailability of trifluridine [F649]. Trifluridine monophosphate also reversibly inhibits thymidylate synthetase (TS), an enzyme that is necessary for DNA synthesis and which levels are shown to be elevated different cancer cell lines [A35289]. Up-regulation of the expression of the TS enzyme may also lead to the resistance to antineoplastic therapies, such as 5-fluorouracil (5-FU). [A35289 However, this inhibitory effect is not considered to be sufficient enough to fully contribute to the cytotoxicity in cancer cells. [A35272]
|
After oral administration of LONSURF with [14C]-trifluridine, at least 57% of the administered trifluridine was absorbed. Following a single dose of LONSURF (35 mg/m<sup>2</sup>) in patients with advanced solid tumors, the mean times to peak plasma concentrations (T<sub>max</sub>) of trifluridine was around 2 hours.[L47681] Trifluridine area under the concentration-time curve from time 0 to the last measurable concentration (AUC<sub>0-last</sub>) was approximately 3-fold higher and maximum concentration (C<sub>max</sub>) was approximately 2-fold higher after multiple dose administration (twice daily for 5 days a week with 2 days rest for 2 weeks followed by a 14-day rest, repeated every 4 weeks) than after single-dose administration.[L47681]
Following a single oral administration of LONSURF at 35 mg/m<sup>2</sup> in patients with cancer, the mean time to peak plasma concentration (T<sub>max</sub>) of trifluridine was around 2 hours.[L47676] For the ophthalmic formulation, systemic absorption appears to be negligible.[L47671] A standardized high-fat, high-calorie meal decreased trifluridine C<sub>max</sub> by approximately 40% but did not change trifluridine AUC compared to those in a fasting state in patients with cancer following administration of a single dose of LONSURF 35 mg/m<sup>2</sup>.[L47671]
In a dose finding study (15 to 35 mg/m<sup>2</sup> twice daily), the AUC from time 0 to 10 hours (AUC0-10) of trifluridine tended to increase more than expected based on the increase in dose.[L47681]
|
Trifluridine is not metabolized by cytochrome P450 (CYP) enzymes. Trifluridine is mainly eliminated by metabolism via thymidine phosphorylase to form an inactive metabolite, 5-(trifluoromethyl) uracil (FTY). No other major metabolites were detected in plasma or urine.[L47676] Other minor metabolites, such as 5-carboxy-2'-deoxyuridine found on the endothelial side of the cornea or 5-carboxyuraci, were also detected, but only at low or trace level in plasma and urine.[A35307, L47681]
|
Intravenous LD50 in rat was 2946 mg/kg [MSDS]. Oral LD50 in rat and mouse were > 4379mg/kg [MSDS]. Overdosage via ocular instillation is unlikely. The highest dose of orally-administered Lonsurf, trifluridine in combination with tipiracil, administered in clinical studies was 180 mg/m^2 per day. The primary anticipated complication of an overdose is bone marrow suppression. There is no known antidote for trifluridine overdose: in case of an overdose, management should include customary therapeutic and supportive medical intervention aimed at correcting the presenting clinical manifestations and preventing their possible complications [F649]. Based on the findings from animal studies, trifluridine may cause fetal toxicity when administered to pregnant patients [F649].
|
After administration of LONSURF 35 mg/m<sup>2</sup>, the mean elimination and steady-state half-life (t<sub>1/2</sub>) of trifluridine was 1.4 hours and 2.1 hours respectively.[L47676] For the ophthalmic formulation, the half-life is significantly shorter, approximately only 12 minutes.[L47671]
|
_In vitro_ findings suggest that the protein binding of trifluridine in human plasma is greater than 96%, where it is mainly bound to human serum albumin. Protein binding of trifluridine is independent of drug concentration and presence of tipiracil.[L47676]
|
After single oral administration of LONSURF (60 mg) with [14C]-trifluridine, the total cumulative excretion of radioactivity was 60% of the administered dose. The majority of
recovered radioactivity was eliminated into urine (55% of the dose) as FTY and trifluridine glucuronide isomers within 24 hours and the excretion into feces and expired air was <3% for
both. The unchanged trifluridine was <3% of administered dose recovered in the urine and feces.[L47676]
|
Following a single dose of LONSURF (35 mg/m<sup>2</sup>) in patients with advanced solid tumours, the apparent volume of distribution (Vd/F) for trifluridine was 21 L.[L47681]
|
Following a single dose of LONSURF (35 mg/m<sup>2</sup>) in patients with advanced solid tumours, the oral clearance (CL/F) for trifluridine was 10.5 L/hr.[L47681]
|
Organic compounds
|
Nucleosides, nucleotides, and analogues
|
Pyrimidine nucleosides
|
Pyrimidine 2'-deoxyribonucleosides
|
[
"approved",
"investigational"
] |
[
"L01BC",
"L01B",
"L01",
"L",
"S01AD",
"S01A",
"S01",
"S"
] |
[
"Human Herpes Virus"
] |
[
{
"cost": "3.41",
"description": "Sandoz Trifluridine 1 % Solution",
"unit": "ml"
},
{
"cost": "15.21",
"description": "Trifluridine 1 % opth soln",
"unit": "ml"
},
{
"cost": "18.63",
"description": "Viroptic 1% eye drops",
"unit": "ml"
},
{
"cost": "19.69",
"description": "Trifluridine 1% eye drops",
"unit": "ml"
},
{
"cost": "153.4",
"description": "Trifluridine 1% Solution 7.5ml Bottle",
"unit": "bottle"
},
{
"cost": "160.07",
"description": "Viroptic 1% Solution 7.5ml Bottle",
"unit": "bottle"
}
] |
[
{
"approved": "2010-09-21",
"country": "United States",
"expires": "2026-12-16",
"number": "7799783"
},
{
"approved": "1998-04-28",
"country": "United States",
"expires": "2016-03-28",
"number": "5744475"
},
{
"approved": "2002-11-12",
"country": "United States",
"expires": "2020-03-16",
"number": "6479500"
},
{
"approved": "2016-12-27",
"country": "United States",
"expires": "2034-06-17",
"number": "9527833"
},
{
"approved": "2017-01-24",
"country": "United States",
"expires": "2026-12-16",
"number": "RE46284"
},
{
"approved": "2019-10-29",
"country": "United States",
"expires": "2037-02-03",
"number": "10456399"
},
{
"approved": "2019-10-29",
"country": "United States",
"expires": "2034-06-17",
"number": "10457666"
},
{
"approved": "2021-03-30",
"country": "United States",
"expires": "2037-02-03",
"number": "10960004"
},
{
"approved": "2018-04-17",
"country": "United States",
"expires": "2034-09-05",
"number": "9943537"
}
] |
5-(Trifluoromethyl)deoxyuridine | 5-Trifluoromethyl-2-deoxyuridine | F₃T | TFT | Trifluoromethyldeoxyuridine | Trifluorothymidine | Trifluorothymine deoxyriboside | Trifluridin | Trifluridina | Trifluridine | Trifluridinum | 2.1.1.45 | CDC21 | TS | TSA1 | 2.1.1.45 | TS | TSase | 2.7.1.21 | 2.4.2.4 | ECGF1 | Gliostatin | PD-ECGF | Platelet-derived endothelial cell growth factor | TdRPase | TP | hOAT1 | hPAHT | hROAT1 | OAT1 | Organic anion transporter 1 | PAH transporter | PAHT | Renal organic anion transporter 1 | CNT 1 | CNT1 | Concentrative nucleoside transporter 1 | hCNT1 | Na(+)/nucleoside cotransporter 1 | Sodium-coupled nucleoside transporter 1 | Solute carrier family 28 member 1 | ENT1 | Equilibrative NBMPR-sensitive nucleoside transporter | Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter | es nucleoside transporter | hENT1 | Nucleoside transporter, es-type | Solute carrier family 29 member 1 | 36 kDa nucleolar protein HNP36 | Delayed-early response protein 12 | DER12 | ENT2 | Equilibrative NBMPR-insensitive nucleoside transporter | Equilibrative nitrobenzylmercaptopurine riboside-insensitive nucleoside transporter | hENT2 | HNP36 | Hydrophobic nucleolar protein, 36 kDa | Nucleoside transporter, ei-type | Solute carrier family 29 member 2
|
[
"Apo-trifluridine Ophthalmic Solution",
"Lonsurf",
"Lonsurf",
"Lonsurf",
"Lonsurf",
"Lonsurf",
"Lonsurf",
"Lonsurf",
"Lonsurf",
"Lonsurf",
"Lonsurf",
"Sandoz Trifluridine",
"Trifluridine",
"Trifluridine",
"Trifluridine",
"Viroptic",
"Viroptic",
"Viroptic"
] |
[
"Thilol",
"Triflumann",
"Triherpine",
"Virophta"
] |
[
"Lonsurf",
"Lonsurf",
"Lonsurf",
"Lonsurf",
"Lonsurf",
"Lonsurf",
"Lonsurf",
"Lonsurf",
"Lonsurf",
"Lonsurf"
] |
[
"P04818"
] |
[
"P04183",
"P19971"
] |
[
"P02768"
] |
[
"Q4U2R8",
"O00337",
"Q99808",
"Q14542"
] |
DB00433
|
Prochlorperazine
|
Prochlorperazine, also known as compazine, is a piperazine phenothiazine and first-generation antipsychotic drug that is used for the treatment of severe nausea and vomiting, as well as short-term management of psychotic disorders such as generalized non-psychotic anxiety and schizophrenia.[label] It mainly works by depressing the chemoreceptor trigger zone and blocking D2 dopamine receptors in the brain. It was shown to also block histaminergic, cholinergic and noradrenergic receptors.[L6637] Prochlorperazine was first developed in the 1950s [L6643] and was first approved by the FDA in 1956. Although newer antiemetic agents such as 5-HT3 antagonists are more heavily promoted, prochlorperazine is still widely used in nausea and vomiting.[L6640]
|
solid
|
Indicated for the symptomatic treatment of severe nausea and vomiting.[label]
Indicated for the management of manifestations of psychotic disorders, such as schizophrenia and generalized non-psychotic anxiety. The use of prochlorperazine for the management of generalized non-psychotic anxiety is typically not a first-line therapy and should be limited to doses of less than 20 mg per day or for shorter than 12 weeks.[label,L6634]
Off-label uses include use in emergency settings for adult and pediatric migraines. The American Headache Society recommends the use of prochlorperazine as the first-line medication in this setting. In pediatric migraines, a non-steroidal anti-inflammatory agent is often used in combination with dopamine antagonist.[L6637]
|
Prochlorperazine is an antipsychotic agent that works to promote postsynaptic inhibition of dopaminergic neurons.[L6640] It also exerts its anti-emetic actions via anti-dopaminergic effects, where it displays similar efficacy as ondansteron, a 5HT-3 receptor antagonist and anti-emetic, in preventing delayed nausea and vomiting.[A179179] Prochlorperazine was shown to inhibit histaminergic, cholinergic and alpha-1 adrenergic receptors.[A179173,L6637] The blockade of alpha-1 adrenergic receptors may result in sedation, muscle relaxation, and hypotension. It displays anti-anxiety effects as well.[L6640] Compared to other phenothiazine derivatives, prochlorperazine is less sedating and has a weak propensity for causing hypotension or potentiating the effects of CNS depressants and anesthetics.[L6646] Other than its primary action on D2 receptors, one study showed that prochlorperazine may inhibit the P2X7 receptor in human macrophages, leading to inhibition of calcium ion influx.[L6637]
|
The mechanism of action of prochlorperazine has not been fully determined, but may be primarily related to its anti-dopaminergic effects. Prochlorperazine blocks the D2 dopamine receptors in the brain, which are somatodendritic autoreceptors. Inhibition of D2 receptor signaling results in the blockade of postsynaptic dopamine receptors in the mesolimbic system [L6643] and an increased dopamine turnover. Nausea and vomiting are proposed to arise from peripheral or central stimulation of serotonin type 3 (5-HT3) and dopamine type 2 receptors, the predominant receptors expressed at the chemoreceptor trigger zone (CTZ).[A179194,L6643] Prochlorperazine exerts antiemetic effects and was shown to inhibit apomorphine-induced vomiting by blocking D2 dopamine receptors in the CTZ.[A179179].
|
Following oral administration, prochlorperazine is reported to be well absorbed from the gastrointestinal tract. The onset of pharmacological action is about 30 to 40 minutes following oral administration and 10 to 20 minutes following intramuscular administration. The duration of action for all routes is about 3 to 4 hours.[L6646] Following oral administration in healthy volunteers, the mean oral bioavailability was about 12.5%. In these patients, the time to reach the peak plasma concentrations was about 5 hours. Repeated oral dosing resulted in an accumulation of prochlorperazine and its metabolite. Following multiple twice daily dosing, the steady state of prochlorperazine was reached by 7 days.[A179173]
|
Prochlorperazine undergoes hepatic metabolism involving oxidation, hydroxylation, demethylation, sulfoxide formation and conjugation with glucuronic acid.[L6649] The oxidation reaction is mediated by CYP2D6.[A179179] N-desmethyl prochlorperazine was detected in the plasma[A179173], as well as prochlorperazine sulfoxide, prochlorperazine 7-hydroxide and prochlorperazine sulfoxide 4'-N-oxide, following oral and buccal administration.[A179188] Prochlorperazine may enter the enterohepatic circulation.[L6646]
|
**LD<sub>50</sub> and Overdose**
Oral LD<sub>50</sub> in rats is 750 mg/kg. Intraperitoneal and subcutaneous LD<sub>50</sub> in mice are 191 mg/kg and 320 mg/kg, respectively.[MSDS] In placebo-controlled trials, there were increased incidences of mortality in elderly patients with dementia-related psychosis receiving antipsychotic medications. The risk of death in drug-treated patients was about 1.6 to 1.7 times that of placebo-treated patients. Deaths were largely resulting from cardiovascular, such as heart failure and sudden death, or infectious, such as pneumonia, conditions.[label] Due to its antagonist action on dopamine receptors, prochlorperazine is associated with a risk for developing extrapyramidal symptoms such as tardive dyskinesia, which is a syndrome consisting of potentially irreversible, involuntary, dyskinetic movements. This risk is also conferred on other antipsychotic agents that block dopamine receptors. It is proposed that increased duration of the drug treatment is likely thus increased total cumulative dose of antipsychotic drugs administered to the patient leads to increased risk for developing the syndrome and the likelihood that it will become irreversible. As with other antipsychotic agents, prochlorperazine is associated with a risk for causing neuroleptic malignant syndrome (NMS), which is a potentially fatal symptom complex, which is manifested as hyperpyrexia, muscle rigidity, altered mental status and evidence of autonomic instability.
There is no known antidote for prochlorperazine thus overdose treatment should be supportive and symptomatic. Overdose of prochlorperazine may produce dystonic reactions that involve extrapyramidal mechanism. To reduce these symptoms, antiparkinsonism drugs, barbiturates, or diphenhydramine may be used. Symptoms of central nervous system depression, such as somnolence or coma, may also be observed. Amphetamine, destroamphetamine, or caffeine and sodium benzoate may be used to induce stimulatory effects. In contrast, agitation and restlessness may also be seen in case of overdose. Other possible manifestations include convulsions, EKG changes and cardiac arrhythmias, fever, and autonomic reactions such as hypotension, dry mouth and ileus. Hypotension can be responded with the standard measures for managing circulatory shock.[label]
**Nonclinical Toxicology**
In a rat developmental or reproductive toxicity study, abnormalities in both the reproductive measures and neurobehavioral testing were observed following administration of 25 mg/kg of prochlorperazine.[L6649]
**Use in specific populations**
As the use of antipsychotic agents during the third trimester of pregnancy is associated with a risk for extrapyramidal and/or withdrawal symptoms following delivery, the use of prochlorperazine in pregnant patients is generally not recommended and it should be limited after careful consideration of the potential benefit of drug therapy justifying the potential risk to the fetus. Caution should be exercised when prochlorperazine is administered to a nursing mother. While lower doses of prochlorperazine is reported to be safe for elderly patients, caution is still advised, especially those with higher susceptibility to hypotension and neuromuscular reactions.[label]
|
Following intravenous and single oral dose administration, the terminal elimination half live were 9 and 8 hours, respectively.[A179173]
|
There is limited data on protein binding of prochlorperazine.
|
Prochlorperazine is reported to be mainly excreted via the feces and bile.[L6646] Low quantities of unchanged prochlorperazine and its metabolite were detectable in the urine.[A179173]
|
In a preliminary pharmacokinetic study involving healthy volunteers, the mean apparent volume of distribution following intravenous administration of 6.25 mg and 12.5 mg prochlorperazine were approximately 1401 L and 1548 L, respectively.[A179185] Prochlorperazine is reported to be distributed to most body tissues with high concentrations being distributed into liver and spleen.[L6646] There is evidence that phenothiazines are excreted in the breast milk of nursing mothers.[label]
|
The mean plasma clearance (CL) of prochlorperazine following intravenous administration in healthy volunteers was approximately 0.98L/h x kg. The mean renal clearance was about 23.6 mL/h.[A179173]
|
Organic compounds
|
Organoheterocyclic compounds
|
Benzothiazines
|
Phenothiazines
|
[
"approved",
"vet_approved"
] |
[
"N05AB",
"N05A",
"N05",
"N"
] |
[
"Humans and other mammals"
] |
[
{
"cost": "1.22",
"description": "Prochlorperazine 5 mg/ml vial",
"unit": "ml"
},
{
"cost": "1.8",
"description": "Compazine 10 mg tablet",
"unit": "tablet"
},
{
"cost": "1.82",
"description": "Compazine 5 mg tablet",
"unit": "tablet"
},
{
"cost": "3.05",
"description": "Compro 25 mg suppository",
"unit": "suppository"
},
{
"cost": "3.13",
"description": "Prochlorperazine 25 mg suppository",
"unit": "suppository"
},
{
"cost": "4.25",
"description": "Compazine 25 mg suppository",
"unit": "suppository"
},
{
"cost": "4.77",
"description": "Prochlorperazine mal powder",
"unit": "g"
},
{
"cost": "0.09",
"description": "Novamine 15% iv solution",
"unit": "ml"
},
{
"cost": "0.17",
"description": "Apo-Prochlorazine 5 mg Tablet",
"unit": "tablet"
},
{
"cost": "0.21",
"description": "Apo-Prochlorazine 10 mg Tablet",
"unit": "tablet"
},
{
"cost": "0.57",
"description": "Prochlorperazine 5 mg tablet",
"unit": "tablet"
},
{
"cost": "0.59",
"description": "Prochlorperazine Maleate 5 mg tablet",
"unit": "tablet"
},
{
"cost": "0.85",
"description": "Prochlorperazine 10 mg tablet",
"unit": "tablet"
},
{
"cost": "0.87",
"description": "Sandoz Prochlorperazine 10 mg Suppository",
"unit": "suppository"
},
{
"cost": "0.88",
"description": "Prochlorperazine Maleate 10 mg tablet",
"unit": "tablet"
},
{
"cost": "0.91",
"description": "Prochlorperazine 5 mg/ml",
"unit": "ml"
}
] |
[] |
2-Chloro-10-(3-(1-methyl-4-piperazinyl)propyl)-phenothiazine | 2-Chloro-10-(3-(4-methyl-1-piperazinyl)propyl)phenothiazine | 3-Chloro-10-(3-(1-methyl-4-piperazinyl)propyl)phenothiazine | 3-Chloro-10-(3-(4-methyl-1-piperazinyl)propyl)phenothiazine | Capazine | Chlormeprazine | Chloro-3 (N-methylpiperazinyl-3 propyl)-10 phenothiazine | Chloropernazine | N-(gamma-(4'-Methylpiperazinyl-1')propyl)-3-chlorophenothiazine | Prochlorperazin | Prochlorpérazine | Prochlorperazine | Prochlorperazinum | Prochlorpermazine | Prochlorpromazine | Procloperazine | Proclorperazina | Dopamine D2 receptor | H1-R | H1R | HH1R | ADRA1C | Alpha-1A adrenoceptor | Alpha-1A adrenoreceptor | Alpha-1C adrenergic receptor | Alpha-adrenergic receptor 1c | Alpha-1B adrenoceptor | Alpha-1B adrenoreceptor | ADRA1A | Alpha-1A adrenergic receptor | Alpha-1D adrenoceptor | Alpha-1D adrenoreceptor | Alpha-adrenergic receptor 1a | ADRA2R | ADRAR | Alpha-2 adrenergic receptor subtype C10 | Alpha-2A adrenoceptor | Alpha-2A adrenoreceptor | Alpha-2AAR | ADRA2L1 | ADRA2RL1 | Alpha-2 adrenergic receptor subtype C2 | Alpha-2B adrenoceptor | Alpha-2B adrenoreceptor | Alpha-2BAR | ADRA2L2 | ADRA2RL2 | Alpha-2 adrenergic receptor subtype C4 | Alpha-2C adrenoceptor | Alpha-2C adrenoreceptor | Alpha-2CAR | 1.14.14.- | Cholesterol 25-hydroxylase | CYP2DL1 | CYPIID6 | Cytochrome P450-DB1 | Debrisoquine 4-hydroxylase
|
[
"Compazine",
"Compazine",
"Compazine",
"Compazine",
"Compazine",
"Compazine",
"Compazine",
"Compazine",
"Compazine",
"Compazine",
"Compazine",
"Compazine",
"Compazine",
"Compazine",
"Compazine",
"Compazine",
"Compro",
"Compro",
"Compro",
"Compro",
"Nu-prochlor Tab 10mg",
"Nu-prochlor Tab 5mg",
"Odan-prochlorperazine",
"PMS Prochlorperazine Inj 5mg/ml",
"PMS-prochlorperazine Suppositoires 10mg",
"PMS-prochlorperazine Tab 10mg",
"PMS-prochlorperazine Tab 5mg",
"Prochlorazine",
"Prochlorazine",
"Prochlorperazine",
"Prochlorperazine",
"Prochlorperazine",
"Prochlorperazine",
"Prochlorperazine",
"Prochlorperazine",
"Prochlorperazine",
"Prochlorperazine",
"Prochlorperazine Edisylate",
"Prochlorperazine Edisylate",
"Prochlorperazine Edisylate",
"Prochlorperazine Edisylate",
"Prochlorperazine Edisylate",
"Prochlorperazine Edisylate",
"Prochlorperazine Edisylate",
"Prochlorperazine Edisylate",
"Prochlorperazine Edisylate",
"Prochlorperazine Edisylate",
"Prochlorperazine Edisylate",
"Prochlorperazine Edisylate",
"Prochlorperazine Edisylate",
"Prochlorperazine Edisylate",
"Prochlorperazine Edisylate",
"Prochlorperazine Edisylate",
"Prochlorperazine Edisylate",
"Prochlorperazine Edisylate",
"Prochlorperazine Edisylate",
"Prochlorperazine Edisylate",
"Prochlorperazine Edisylate",
"Prochlorperazine Edisylate",
"Prochlorperazine Edisylate",
"Prochlorperazine Edisylate",
"Prochlorperazine Edisylate",
"Prochlorperazine Edisylate",
"Prochlorperazine Edisylate",
"Prochlorperazine Edisylate",
"Prochlorperazine Edisylate",
"Prochlorperazine Edisylate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Maleate",
"Prochlorperazine Mesylate Inj 5mg/ml",
"Stemetil",
"Stemetil",
"Stemetil Liq 5mg/5ml",
"Stemetil Tab 10mg",
"Stemetil Tab 5mg"
] |
[
"Buccastem",
"Emetiral",
"Stemzine",
"Volimin"
] |
[] |
[
"P14416",
"P35367",
"P35348",
"P35368",
"P25100",
"P08913",
"P18089",
"P18825"
] |
[
"P10635"
] |
[] |
[] |
DB00434
|
Cyproheptadine
|
Cyproheptadine is a potent competitive antagonist of both serotonin and histamine receptors.[L32474] It is used primarily to treat allergic symptoms, though it is perhaps more notable for its use in appetite stimulation[L32519] and its off-label use in the treatment of serotonin syndrome.[A231274]
|
solid
|
In the US, prescription cyproheptadine is indicated for the treatment of various allergic symptomatologies - including dermatographia, rhinitis, conjunctivitis, and urticaria - as well as adjunctive therapy in the management of anaphylaxis following treatment with epinephrine.[L32474] In Canada, cyproheptadine is available over-the-counter and is indicated for the treatment of pruritus and for appetite stimulation.[L32519] In Australia, cyproheptadine is additionally indicated for the treatment vascular headaches.[L32479]
Cyproheptadine is also used off-label for the treatment of serotonin syndrome.[A231274]
|
Cyproheptadine has been observed to antagonize several pharmacodynamic effects of serotonin in laboratory animals, including bronchoconstriction and vasodepression, and has demonstrated similar efficacy in antagonizing histamine-mediated effects.[L32479] The reason for its efficacy in preventing anaphylactic shock has not been elucidated, but appears to be related to its anti-serotonergic effects.[L32479]
|
Cyproheptadine appears to exert its antihistamine and antiserotonin effects by competing with free histamine and serotonin for binding at their respective receptors.[L32479] Antagonism of serotonin on the appetite center of the hypothalamus may account for cyproheptadine's ability to stimulate the appetite.
|
A single study examining the difference in absorption of orally administered versus sublingually administered cyproheptadine in five healthy males demonstrated a mean C<sub>max</sub> of 30.0 mcg/L and 4.0 mcg/L, respectively, and a mean AUC of 209 mcg.h/L and 25 mcg.h/L, respectively.[A179503] The T<sub>max</sub> of orally and sublingually administered cyproheptadine was 4 hours and 9.6 hours, respectively.[A179503]
|
The principal metabolite found in human urine has been identified as a quaternary ammonium glucuronide conjugate of cyproheptadine.[L32474]
|
Overdosage with cyproheptadine is likely to result in significant sedation - although paradoxical stimulation has been noted in pediatric patients - and anticholinergic adverse effects such as dry mouth and flushing.[L32474] Most patients appear to recover without incident, as a review of cyproheptadine overdose cases in Hong Kong found the majority of patients had no or mild symptoms following intentional overdose.[A231759]
In the event of overdosage with cyproheptadine, prescribing information recommends the induction of vomiting (if it has not occurred spontaneously) using syrup of ipecac.[L32474] Gastric lavage and activated charcoal may also be considered. Vasopressors may be used to treat hypotension and intravenous physostigmine salicylate may be considered for the treatment of significant CNS symptoms depending on the clinical picture.[L32474]
| null | null |
Approximately 2-20% of the radioactivity from an orally administered radio-labeled dose of cyproheptadine is excreted in the feces, of which approximately 34% is unchanged parent drug (less than 5.7% of the total dose).[L32479] At least 40% of radioactivity is recovered in the urine.[L32479]
| null | null |
Organic compounds
|
Benzenoids
|
Dibenzocycloheptenes
| null |
[
"approved"
] |
[
"R06AX",
"R06A",
"R06",
"R"
] |
[
"Humans and other mammals"
] |
[
{
"cost": "7.34",
"description": "Cyproheptadine hcl powder",
"unit": "g"
},
{
"cost": "0.16",
"description": "Cyproheptadine HCl 2 mg/5ml Syrup",
"unit": "ml"
},
{
"cost": "0.43",
"description": "Cyproheptadine 4 mg tablet",
"unit": "tablet"
},
{
"cost": "0.47",
"description": "Cyproheptadine HCl 4 mg tablet",
"unit": "tablet"
}
] |
[] |
1-methyl-4-(5-dibenzo(a,e)cycloheptatrienylidene)piperidine | 1-Methyl-4-(5H-dibenzo(a,d)cycloheptenylidene)piperidine | 4-(5-dibenzo(a,d)cyclohepten-5-ylidine)-1-methylpiperidine | 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-methylpiperidine | 4-Dibenzo[a,d]cyclohepten-5-ylidene-1-methyl-piperidine | 5-(1-methylpiperidylidene-4)-5H-dibenzo(a,d)cyclopheptene | Ciproheptadina | Cyproheptadin | Cyproheptadine | Cyproheptadinum | H1-R | H1R | HH1R | 5-HT-2 | 5-HT-2A | HTR2 | Serotonin receptor 2A | 5-HT-1C | 5-HT-2C | 5-HT1C | 5-HT2C | 5-HTR2C | 5-hydroxytryptamine receptor 1C | HTR1C | Serotonin receptor 2C | Gastric receptor I | H2R | HH2R | 5-HT-2B | 5-HT2B | Serotonin receptor 2B | 5-HT-7 | 5-HT-X | 5-HT7 | Serotonin receptor 7 | 2.4.1.17 | GNT1 | UDP-glucuronosyltransferase 1-3 | UDP-glucuronosyltransferase 1-C | UDP-glucuronosyltransferase 1A isoform 3 | UDPGT 1-3 | UGT-1C | UGT1 | UGT1-03 | UGT1.3 | UGT1*3 | UGT1A3 | UGT1C | 2.4.1.17 | Bilirubin-specific UDPGT isozyme 2 | GNT1 | hUG-BR2 | UDP-glucuronosyltransferase 1-4 | UDP-glucuronosyltransferase 1-D | UDPGT 1-4 | UGT-1D | UGT1 | UGT1-04 | UGT1.4 | UGT1*4 | UGT1A4 | UGT1D | 2.4.1.17 | UDPGT 2B10 | hOCT1 | OCT1 | Organic cation transporter 1
|
[
"Cyproheptadine",
"Cyproheptadine",
"Cyproheptadine",
"Cyproheptadine",
"Cyproheptadine Hydrochloride",
"Cyproheptadine Hydrochloride",
"Cyproheptadine Hydrochloride",
"Cyproheptadine Hydrochloride",
"Cyproheptadine Hydrochloride",
"Cyproheptadine Hydrochloride",
"Cyproheptadine Hydrochloride",
"Cyproheptadine Hydrochloride",
"Cyproheptadine Hydrochloride",
"Cyproheptadine Hydrochloride",
"Cyproheptadine Hydrochloride",
"Cyproheptadine Hydrochloride",
"Cyproheptadine Hydrochloride",
"Cyproheptadine Hydrochloride",
"Cyproheptadine Hydrochloride",
"Cyproheptadine Hydrochloride",
"Cyproheptadine Hydrochloride",
"Cyproheptadine Hydrochloride",
"Cyproheptadine Hydrochloride",
"Cyproheptadine Hydrochloride",
"Cyproheptadine Hydrochloride",
"Cyproheptadine Hydrochloride",
"Cyproheptadine Hydrochloride",
"Cyproheptadine Hydrochloride",
"Cyproheptadine Hydrochloride",
"Cyproheptadine Hydrochloride",
"Cyproheptadine Hydrochloride",
"Cyproheptadine Hydrochloride",
"Cyproheptadine Hydrochloride",
"Cyproheptadine Hydrochloride",
"Cyproheptadine Hydrochloride",
"Cyproheptadine Hydrochloride",
"Cyproheptadine Hydrochloride",
"Cyproheptadine Hydrochloride",
"Cyproheptadine Hydrochloride",
"Cyproheptadine Hydrochloride",
"Cyproheptadine Hydrochloride",
"Cyproheptadine Hydrochloride",
"Cyproheptadine Hydrochloride",
"Cyproheptadine Hydrochloride",
"Cyproheptadine Hydrochloride",
"Cyproheptadine Hydrochloride",
"Cyproheptadine Hydrochloride",
"Cyproheptadine Hydrochloride",
"Cyproheptadine Hydrochloride",
"Cyproheptadine Hydrochloride",
"Cyproheptadine Hydrochloride",
"Cyproheptadine Hydrochloride",
"Cyproheptadine Hydrochloride",
"Cyproheptadine Hydrochloride",
"Cyproheptadine Hydrochloride",
"Cyproheptadine Hydrochloride",
"Cyproheptadine Hydrochloride",
"Cyproheptadine Hydrochloride",
"Cyproheptadine Hydrochloride",
"Cyproheptadine Hydrochloride",
"Cyproheptadine Hydrochloride",
"Cyproheptadine Hydrochloride",
"Cyproheptadine Hydrochloride",
"Cyproheptadine Hydrochloride",
"Cyproheptadine Hydrochloride",
"Cyproheptadine Hydrochloride",
"Cyproheptadine Hydrochloride",
"Cyproheptadine Hydrochloride",
"Cyproheptadine Hydrochloride",
"Cyproheptadine Hydrochloride",
"Cyproheptadine Hydrochloride",
"Cyproheptadine Hydrochloride",
"Cyproheptadine Hydrochloride",
"Cyproheptadine Hydrochloride",
"Cyproheptadine Hydrochloride",
"Cyproheptadine Hydrochloride",
"Cyproheptadine Hydrochloride",
"Cyproheptadine Hydrochloride",
"Cyproheptadine Hydrochloride",
"Cyproheptadine Hydrochloride",
"Cyproheptadine Hydrochloride",
"Cyproheptadine Hydrochloride",
"Cyproheptadine Hydrochloride",
"Cyproheptadine Hydrochloride",
"Cyproheptadine Hydrochloride",
"Cyproheptadine Hydrochloride",
"Cyproheptadine Hydrochloride",
"Cyproheptadine Hydrochloride Solution",
"Euro-cyproheptadine 2mg/5ml",
"Euro-cyproheptadine 4 Mg/tablet",
"Jamp Cyproheptadine Syrup",
"Jamp-cyproheptadine",
"Mar-cyproheptadine",
"Periactin Syr 2mg/5ml",
"Periactin Tab 4mg",
"PMS-cyproheptadine HCl Tab 4mg",
"Sandoz Cyproheptadine",
"Sandoz Cyproheptadine Tablet"
] |
[
"Apeplus",
"Apitup",
"Biohept",
"Ciplactin",
"Cipractine",
"Ciproheptadina",
"Ciprovit",
"Ciptadine",
"Cyheptine",
"Cyllermin",
"Periactin",
"Periactine",
"Periatin",
"Reactin"
] |
[] |
[
"P35367",
"P28223",
"P28335",
"P25021",
"P41595",
"P11229",
"P08172",
"P20309",
"P34969"
] |
[
"P35503",
"P22310",
"P36537"
] |
[
"P02768"
] |
[
"O15245"
] |
DB00437
|
Allopurinol
|
Gout is a disease that occurs by the deposition of monosodium urate crystals (MSU) in body tissues, especially around joints [A175942]. This disease has been well-documented in historical medical records and appears in the biographies of several prominent, historically recognized individuals [A175942].
Allopurinol is a xanthine oxidase enzyme inhibitor that is considered to be one of the most effective drugs used to decrease urate levels and is frequently used in the treatment of chronic gout [A36705]. It was initially approved by the FDA in 1966 [L5674] and is now formulated by several manufacturers [L5677].
|
solid
|
Allopurinol is indicated in [FDA label]:
1) the management of patients with signs and symptoms of primary or secondary gout (acute attacks, tophi, joint destruction, uric acid lithiasis, and/or nephropathy).
2) the management of patients with leukemia, lymphoma and malignancies who are receiving cancer therapy which causes elevations of serum and urinary uric acid levels. Treatment with allopurinol should be discontinued when the potential for overproduction of uric acid is no longer present.
3) the management of patients with recurrent calcium oxalate calculi whose daily uric acid excretion exceeds 800 mg/day in male patients and 750 mg/day in female patients. Therapy in such patients should be carefully assessed initially and reassessed periodically to determine in each case that treatment is beneficial and that the benefits outweigh the risks.
|
Allopurinol decreases the production of uric acid by stopping the biochemical reactions that precede its formation [FDA label]. This process decreases urate and relieves the symptoms of gout, which may include painful tophi, joint pain, inflammation, redness, decreased range of motion, and swelling [A665].
|
Allopurinol is a structural analog of the natural purine base, hypoxanthine. After ingestion, allopurinol is metabolized to its active metabolite, oxypurinol (_alloxanthine_) in the liver [T508], which acts as an inhibitor of xanthine oxidase enzyme [FDA label].
Allopurinol and its active metabolite inhibit xanthine oxidase, the enzyme that converts hypoxanthine to xanthine and xanthine to uric acid. Inhibition of this enzyme is responsible for the effects of allopurinol. This drug increases the reutilization of hypoxanthine and xanthine for nucleotide and nucleic acid synthesis by a process that involves the enzyme hypoxanthine-guanine phosphoribosyltransferase (HGPRTase). This process results in an increased nucleotide concentration, which causes feedback inhibition of de novo purine synthesis. The end result is decreased urine and serum uric acid concentrations [F3988], which decreases the incidence of gout symptoms.
Accompanying the reduction of serum uric acid by allopurinol is an increase in the serum and urine concentrations of hypoxanthine and xanthine (due to inhibition of xanthine oxidase). In the absence of allopurinol, regular urinary excretion of oxypurines almost entirely occurs in the form of uric acid. After the ingestion of allopurinol, the contents of excreted urine are hypoxanthine, xanthine, and uric acid. Because each substance has its own individual solubility, the concentration of uric acid in plasma is decreased without exposing the renal tissues to a high load of uric acid, thereby decreasing the risk of crystalluria. By lowering the uric acid concentration in the plasma below its limits of solubility, allopurinol encourages the dissolution of gout tophi. Although the levels of hypoxanthine and xanthine are found to be increased after allopurinol ingestion, the risk of deposition in renal tissues is less than that of uric acid, as they become more soluble and are rapidly excreted by the kidney [F3988].
|
This drug is about 90% absorbed from the gastrointestinal tract. Peak plasma levels normally occur at 1.5 hours and 4.5 hours post-dose for allopurinol and oxipurinol respectively. Following one oral dose of 300 mg of allopurinol, maximum plasma levels of about 3 mcg/mL of allopurinol and 6.5 mcg/mL of oxipurinol were measured [FDA label].
|
Allopurinol is rapidly metabolized to the corresponding xanthine analog, oxipurinol (alloxanthine), which is also an inhibitor of xanthine oxidase enzyme [FDA label].
Both allopurinol and oxypurinol inhibit the action of this enzyme. Allopurinol and oxypurinol are also converted by the purine salvage pathway to their respective ribonucleotides. The effect of these ribonucleotides related to the hypouricemic action of allopurinol in humans is not fully elucidated to this date. These metabolites may act to inhibit de novo purine biosynthesis by inhibiting the enzyme, _amidophosphoribosyltransferase_. The ribonucleotides have not been found to be incorporated in DNA [A175945].
|
**Oral TDLO** (rat): 10 mg/kg; **Oral LD50** (mouse): 78 mg/kg; **Oral TDLO (mouse)**: 100 mg/kg [F3985]
**Use in pregnancy**
Reproductive studies have been completed using rats and rabbit models at doses up to twenty times the normal human dose ( about 5 mg/kg per day), and it was concluded that fertility was not impaired and there was no fetal harm. There is a published report of a study in pregnant mice administered 50 or 100 mg/kg allopurinol intraperitoneally on gestation days 10 or 13. There were increased numbers of dead fetuses in dams administered 100 mg/kg allopurinol, however, death did not occur in those given 50 mg/kg. There were higher numbers of external malformations in fetuses at both doses of allopurinol on gestation day 10 and higher numbers of skeletal malformations in fetuses at both doses on gestation day 13. Despite the above findings, there are no adequate or well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if it is absolutely required [FDA label].
**Use in nursing**
Both allopurinol and the metabolite oxipurinol have been found in the milk of a mother who was receiving allopurinol. Since the effect of allopurinol on the nursing infant is unknown, it is advisable to exercise caution when allopurinol is taken by a nursing woman [FDA label].
**Mutagenicity and carcinogenicity**
Cytogenic studies demonstrate that allopurinol does not induce chromosomal abnormalities in human blood cells in vitro at concentrations up to 100 g/mL and in vivo at doses up to 60 mg/day for an average duration of 40 months. Allopurinol does not form nitroso compounds (which may be carcinogenic) or affect lymphocyte transformation in vitro. Evidence suggests that allopurinol does not have deleterious effects on DNA at any stage of the cell cycle and was not found to be mutagenic. No evidence of carcinogenicity has been observed in mice treated with allopurinol for up to a 2 year period [F3988].
|
The plasma half-life of allopurinol is 1-2 hours, due to its rapid renal clearance [FDA label].
|
Allopurinol and oxypurinol are only negligibly bound to plasma proteins [A175954, A175948].
|
Approximately 80% of orally ingested allopurinol is found excreted in the urine as various metabolites [A175948]. About 20% of ingested allopurinol is excreted in the feces [FDA label].
|
Allopurinol and oxypurinol are both substrates for the enzyme xanthine oxidase, which is present in the cytoplasm of endothelial cells of capillaries, including sinusoids, with the highest activity demonstrated in the liver and intestinal lining. Tissue concentrations of allopurinol have not yet been reported in humans, however, it is probable that allopurinol and the metabolite oxypurinol would be measured in the highest concentrations in the abovementioned tissues. In animals, allopurinol concentrations are found to reach the highest levels in the blood, liver, intestine and heart, and lowest in the brain and lung tissues [A175948].
|
Since allopurinol and its metabolites are mainly eliminated by the kidney, accumulation of this drug can occur in patients with renal dysfunction or failure, and the dose of allopurinol should, therefore, be reduced. With a creatinine clearance of 10 to 20 mL/min, a daily dosage of 200 mg of allopurinol is suitable. When the creatinine clearance is less than 10 mL/min, the daily dosage should not be higher than 100 mg. With severe renal impairment (creatinine clearance measured at less than 3 mL/min) a longer interval between doses may be required [FDA label].
|
Organic compounds
|
Organoheterocyclic compounds
|
Pyrazolopyrimidines
|
Pyrazolo[3,4-d]pyrimidines
|
[
"approved"
] |
[
"M04AA",
"M04A",
"M04",
"M",
"M04AA",
"M04A",
"M04",
"M"
] |
[
"Humans and other mammals"
] |
[
{
"cost": "1.89",
"description": "Zyloprim 300 mg tablet",
"unit": "tablet"
},
{
"cost": "18.41",
"description": "Allopurinol powder",
"unit": "g"
},
{
"cost": "583.14",
"description": "Allopurinol sodium 500 mg vial",
"unit": "vial"
},
{
"cost": "612.3",
"description": "Aloprim 500 mg vial",
"unit": "vial"
},
{
"cost": "0.04",
"description": "Suspendol-s liquid",
"unit": "ml"
},
{
"cost": "0.08",
"description": "Apo-Allopurinol 100 mg Tablet",
"unit": "tablet"
},
{
"cost": "0.08",
"description": "Novo-Purol 100 mg Tablet",
"unit": "tablet"
},
{
"cost": "0.14",
"description": "Apo-Allopurinol 200 mg Tablet",
"unit": "tablet"
},
{
"cost": "0.14",
"description": "Novo-Purol 200 mg Tablet",
"unit": "tablet"
},
{
"cost": "0.22",
"description": "Apo-Allopurinol 300 mg Tablet",
"unit": "tablet"
},
{
"cost": "0.22",
"description": "Novo-Purol 300 mg Tablet",
"unit": "tablet"
},
{
"cost": "0.24",
"description": "Allopurinol 100 mg tablet",
"unit": "tablet"
},
{
"cost": "0.46",
"description": "Allopurinol 300 mg tablet",
"unit": "tablet"
},
{
"cost": "0.82",
"description": "Zyloprim 100 mg tablet",
"unit": "tablet"
}
] |
[
{
"approved": "2012-10-09",
"country": "United States",
"expires": "2028-11-26",
"number": "8283369"
},
{
"approved": "2011-12-27",
"country": "United States",
"expires": "2029-08-17",
"number": "8084483"
},
{
"approved": "2013-01-22",
"country": "United States",
"expires": "2028-11-26",
"number": "8357713"
},
{
"approved": "2013-10-01",
"country": "United States",
"expires": "2029-04-29",
"number": "8546437"
},
{
"approved": "2015-12-22",
"country": "United States",
"expires": "2030-08-02",
"number": "9216179"
},
{
"approved": "2011-08-23",
"country": "United States",
"expires": "2025-08-25",
"number": "8003681"
},
{
"approved": "2013-10-01",
"country": "United States",
"expires": "2032-02-29",
"number": "8546436"
},
{
"approved": "2018-05-01",
"country": "United States",
"expires": "2031-12-28",
"number": "9956205"
},
{
"approved": "2019-01-22",
"country": "United States",
"expires": "2028-11-26",
"number": "10183012"
}
] |
1,5-Dihydro-4H-pyrazolo(3,4-d)pyrimidin-4-one | 1,5-Dihydro-4H-pyrazolo(3,4-d)pyrimidine-4-one | 1H-Pyrazolo(3,4-d)pyrimidin-4-ol | 4-HPP | 4-Hydroxy-1H-pyrazolo(3,4-d)pyrimidine | 4-Hydroxy-3,4-pyrazolopyrimidine | 4-Hydroxypyrazolo(3,4-d)pyrimidine | 4-Hydroxypyrazolopyrimidine | 4-Hydroxypyrazolyl(3,4-d)pyrimidine | 4'-Hydroxypyrazolol(3,4-d)pyrimidine | 4H-Pyrazolo(3,4-d)pyrimidin-4-one | Allopurinol | Allopurinolum | Alopurinol | XDHA | 1.2.3.1 | Aldehyde oxidase 1 | AO | Azaheterocycle hydroxylase | XDHA | hOAT3 | OAT3 | Organic anion/dicarboxylate exchanger | Solute carrier family 22 member 8 | hOAT2 | NLT | Novel liver transporter | OAT2 | Organic anion transporter 2 | 7.6.2.2 | ABCP | ATP-binding cassette sub-family G member 2 | BCRP | BCRP1 | Breast cancer resistance protein | CDw338 | Mitoxantrone resistance-associated protein | MXR | Placenta-specific ATP-binding cassette transporter | Urate exporter | hOCT2 | OCT2 | Organic cation transporter 2
|
[
"Ag-allopurinol",
"Ag-allopurinol",
"Ag-allopurinol",
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"Alloprin",
"Alloprin",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
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"Allopurinol",
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"Allopurinol",
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"Allopurinol",
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"Allopurinol",
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"Allopurinol",
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"Allopurinol",
"Allopurinol",
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"Allopurinol",
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"Allopurinol",
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"Allopurinol",
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"Allopurinol",
"Allopurinol",
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"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
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"Allopurinol",
"Allopurinol",
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"Allopurinol",
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"Allopurinol",
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"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
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"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol",
"Allopurinol sodium",
"Allopurinol sodium",
"Allopurinol Tablets 100mg",
"Allopurinol Tablets 200mg",
"Allopurinol Tablets 300mg",
"Allopurinol-100",
"Allopurinol-200",
"Allopurinol-300",
"Aloprim",
"Aloprim",
"Apo-allopurinol",
"Apo-allopurinol",
"Apo-allopurinol",
"Apo-allopurinol Tablets",
"Apo-allopurinol Tablets",
"Apo-allopurinol Tablets",
"Duzallo",
"Duzallo",
"Ipg-allopurinol",
"Ipg-allopurinol",
"Ipg-allopurinol",
"Jamp Allopurinol",
"Jamp Allopurinol",
"Jamp Allopurinol",
"Jamp Allopurinol Tablets",
"Jamp Allopurinol Tablets",
"Jamp Allopurinol Tablets",
"Mar-allopurinol",
"Mar-allopurinol",
"Mar-allopurinol",
"Novo-purol Tab 100mg",
"Novo-purol Tab 200 mg",
"Novo-purol Tab 300mg",
"Ntp-allopurinol",
"Ntp-allopurinol",
"Ntp-allopurinol",
"Nu-allopurinol",
"Nu-allopurinol",
"Nu-allopurinol",
"PMS-allopurinol",
"PMS-allopurinol",
"PMS-allopurinol",
"Purinol Tab 100mg",
"Purinol Tab 200mg",
"Purinol Tab 300mg",
"Riva-purinol 100mg Tablets",
"Riva-purinol 200mg Tablets",
"Riva-purinol 300mg Tablets",
"Zyloprim",
"Zyloprim",
"Zyloprim",
"Zyloprim",
"Zyloprim",
"Zyloprim",
"Zyloprim",
"Zyloprim",
"Zyloprim",
"Zyloprim",
"Zyloprim",
"Zyloprim",
"Zyloprim",
"Zyloprim 100",
"Zyloprim 200"
] |
[
"Adenock",
"Allohexal",
"Alloril",
"Aluron",
"Milurit",
"Progout",
"Zyloric",
"Zyrik"
] |
[
"Duzallo",
"Duzallo"
] |
[
"P47989"
] |
[
"Q06278",
"P47989"
] |
[] |
[
"Q8TCC7",
"Q9Y694",
"Q9UNQ0",
"O15244"
] |
DB00438
|
Ceftazidime
|
Bacteria possess a cell wall comprising a glycopeptide polymer commonly known as peptidoglycan, which is synthesized and remodelled through the action of a family of enzymes known as "penicillin-binding proteins" (PBPs).[A232920] β-lactam antibiotics, including cephalosporins, are PBP inhibitors that, through inhibition of essential PBPs, result in impaired cell wall homeostasis, loss of cell integrity, and ultimately bacterial cell death.[A232920, A232925, A232930] Ceftazidime is a third-generation cephalosporin with broad-spectrum antibacterial activity, including against some treatment-resistant bacteria such as _Pseudomonas aeruginosa_.[L32935]
Ceftazidime was approved by the FDA on July 19, 1985, and is currently available either alone or in combination with the non-β-lactam β-lactamase inhibitor [avibactam] to treat a variety of bacterial infections.[L32935, L32940]
|
solid
|
Ceftazidime is indicated for the treatment of lower respiratory tract infections, skin and skin structure infections, urinary tract infections, bacterial septicemia, bone and joint infections, gynecologic infections, intra-abdominal infections (including peritonitis), and central nervous system infections (including meningitis) caused by susceptible bacteria.[L32935]
Ceftazidime is indicated in combination with [avibactam] to treat infections caused by susceptible Gram-negative organisms, including complicated intra-abdominal infections (cIAI), in conjunction with [metronidazole], and complicated urinary tract infections (cUTI), including pyelonephritis, in patients aged three months and older. This combination is also indicated to treat hospital-acquired and ventilator-associated bacterial pneumonia (HABP/VABP) in patients aged 18 years and older.[L45128]
In all cases, to mitigate the risk of bacterial resistance and preserve clinical efficacy, ceftazidime should only be used for infections that are confirmed or strongly suspected to be caused by susceptible bacterial strains.[L32935, L45128]
|
Ceftazidime is a semisynthetic, broad-spectrum, third-generation cephalosporin antibiotic that is bactericidal through inhibition of enzymes responsible for cell-wall synthesis, primarily penicillin-binding protein 3 (PBP3).[L32935] Among cephalosporins, ceftazidime is notable for its resistance to numerous β-lactamases and its broad spectrum of activity against Gram-negative bacteria, including _Pseudomonas aeruginosa_.[A232935] However, it is less active than first- and second-generation cephalosporins against _Staphylococcus aureus_ and other Gram-positive bacteria and also has low activity against anaerobes.[A232935, A233160] Ceftazidime has confirmed activity against clinically relevant Gram-negative bacteria including _Citrobacter_ spp., _Enterobacter_ spp., _Klebsiella_ spp., _Proteus_ spp., _Serratia spp., _Escherichia coli_, _Haemophilus influenzae_, _Neisseria meningitidis_, _Pseudomonas aeruginosa_, and some Gram-positive bacteria including _Staphylococcus_ spp. and _Streptococcus_ spp. There are also _in vitro_ data for ceftazidime efficacy against a wide variety of other bacteria, such as _Acinetobacter baumannii_ and _Neisseria gonorrhoeae_, but no clear clinical studies to support the use of ceftazidime for infections caused by these bacteria.[L32935]
Although β-lactam antibiotics like ceftazidime are generally well tolerated, there remains a risk of serious acute hypersensitivity reactions, which is higher in patients with a known allergy to ceftazidime or any other β-lactam antibiotic. As with all antibiotics, ceftazidime may result in the overgrowth of non-susceptible organisms and potentially serious effects including _Clostridium difficile_-associated diarrhea (CDAD); CDAD should be considered in patients who develop diarrhea and, in confirmed cases, supportive care initiated immediately. Ceftazidime is primarily renally excreted such that high and prolonged serum concentrations can occur in patients with renal insufficiency, leading to seizures, nonconvulsive status epilepticus (NCSE), encephalopathy, coma, asterixis, neuromuscular excitability, and myoclonia. Treatment may lead to the development or induction of resistance with a risk of treatment failure. Periodic susceptibility testing should be considered, and monotherapy failure may necessitate the addition of another antibiotic such as an aminoglycoside. Cephalosporin use may decrease prothrombin activity, which may be improved by exogenous vitamin K. Inadvertent intra-arterial administration of ceftazidime may result in distal necrosis.[L32935]
|
The bacterial cell wall, which is located at the periphery of Gram-positive bacteria and within the periplasm of Gram-negative bacteria, comprises a glycopeptide polymer synthesized through cross-linking of glycans to peptide stems on alternating saccharides, which is known commonly as peptidoglycan.[A232920] Cell wall formation, recycling, and remodelling require numerous enzymes, including a family of enzymes with similar active site character despite distinct and sometimes overlapping roles as carboxypeptidases, endopeptidases, transpeptidases, and transglycosylases, known as "penicillin-binding proteins" (PBPs). The number of PBPs differs between bacteria, in which some are considered essential and others redundant. In general, inhibition of one or more essential PBPs results in impaired cell wall homeostasis, loss of cell integrity, and is ultimately bactericidal.[A232920, A232925, A232930]
Ceftazidime is a semisynthetic third-generation cephalosporin with broad activity against numerous Gram-negative and some Gram-positive bacteria.[L32935] Like other β-lactam antibiotics, ceftazidime exhibits its bactericidal effect primarily through direct inhibition of specific PBPs in susceptible bacteria.[A232935] _In vitro_ experiments in Gram-negative bacteria such as _Escherichia coli_, _Pseudomonas aeruginosa_, _Acinetobacter baumannii_, and _Klebsiella pneumoniae_ suggest that ceftazidime primarily binds to PBP3, with weaker binding to PBP1a/1b and PBP2 as well; although binding to other PBPs, such as PBP4, is detectable, the concentrations required are much greater than those achieved clinically.[A232935, A16721, A232940, A232945, A232950] Similarly, ceftazidime showed binding to _Staphylococcus aureus_ PBP 1, 2, and 3 with a much lower affinity for PBP4.[A16721] Recent data for _Mycobacterium abcessus_ suggest that ceftazidime can inhibit PonA1, PonA2, and PbpA at intermediate concentrations.[A232930]
|
Ceftazidime administered intravenously in healthy males produced mean C<sub>max</sub> values of between 42 and 170 μg/mL for doses between 500 mg and 2 g, and are reached immediately following the end of the infusion period.[L32935] The C<sub>max</sub> for 1 g of ceftazidime administered intramuscularly is attained approximately one hour following injection and is between 37 and 43 mg/L.[A232935] Following intramuscular administration of 500 mg and 1 g of ceftazidime, the serum concentration remained above 4 μg/mL for six and eight hours, respectively.[L32935]
Ceftazidime C<sub>max</sub> and AUC show linear proportionality to the dose over the therapeutic range.[A232935, L32935] In individuals with normal renal function, ceftazidime given intravenously every eight hours for 10 days as either 1 or 2 g doses showed no accumulation.[L32935]
|
Ceftazidime is not appreciably metabolized.[A232935]
|
Ceftazidime overdosage has occurred in patients with renal failure. Reactions included seizure activity, encephalopathy, asterixis, neuromuscular excitability, and coma. Patients who receive an acute overdosage should be carefully observed and given supportive treatment. In the presence of renal insufficiency, hemodialysis or peritoneal dialysis may aid in the removal of ceftazidime from the body.[L32935]
|
Ceftazidime has an elimination half-life of 1.5-2.8 hours in healthy subjects.[A232935, L32935] As ceftazidime is primarily renally excreted, its half-life is significantly prolonged in patients with renal impairment.[L32935] In patients with creatinine clearance < 12 mL/min, the half-life is prolonged to between 14 and 30 hours.[A232935]
|
Ceftazidime plasma protein binding ranges from 5-22.8% (typically less than 10%) and is independent of concentration.[A232935, L32935] Ceftazidime has been shown to bind human serum albumin.[A179053, A233165]
|
Approximately 80% to 90% of an intramuscular or intravenous dose of ceftazidime is excreted unchanged by the kidneys over a 24-hour period. When administered intravenously, 50% of the dose appears in the urine within two hours, with another 32% of the dose appearing by eight hours post-administration.[L32935]
|
Ceftazidime has a volume of distribution of 15-20 L.[A232935]
|
The mean renal clearance of ceftazidime in healthy subjects ranges from 72 to 141 mL/min while the calculated plasma clearance is approximately 115 mL/min.[A232935, L32935]
|
Organic compounds
|
Organoheterocyclic compounds
|
Lactams
|
Beta lactams
|
[
"approved"
] |
[
"J01DD",
"J01D",
"J01",
"J"
] |
[
"Enteric bacteria and other eubacteria"
] |
[
{
"cost": "4.57",
"description": "Tazicef 1 gram vial",
"unit": "vial"
},
{
"cost": "6.27",
"description": "Ceftazidime-sodium carb powder",
"unit": "g"
},
{
"cost": "10.46",
"description": "Ceftazidime 1 gm vial",
"unit": "vial"
},
{
"cost": "10.66",
"description": "Tazicef 2 gram vial",
"unit": "vial"
},
{
"cost": "14.23",
"description": "Fortaz 1 gm vial",
"unit": "vial"
},
{
"cost": "14.71",
"description": "Fortaz 1 gm add-vantage vial",
"unit": "vial"
},
{
"cost": "19.97",
"description": "Ceftazidime 2 gm vial",
"unit": "vial"
},
{
"cost": "25.44",
"description": "Fortaz 1 g/vial",
"unit": "vial"
},
{
"cost": "28.45",
"description": "Fortaz 2 gm vial",
"unit": "vial"
},
{
"cost": "28.93",
"description": "Fortaz 2 gm add-vantage vial",
"unit": "vial"
},
{
"cost": "29.88",
"description": "Tazicef 6 gram vial",
"unit": "vial"
},
{
"cost": "50.01",
"description": "Fortaz 2 g/vial",
"unit": "vial"
},
{
"cost": "82.8",
"description": "Fortaz 6 gm vial",
"unit": "vial"
},
{
"cost": "97.05",
"description": "Ceftazidime 6 gm vial",
"unit": "vial"
},
{
"cost": "150.11",
"description": "Fortaz 6 g/vial",
"unit": "vial"
},
{
"cost": "0.34",
"description": "Fortaz-iso-osmotic 1 gm/50 ml",
"unit": "ml"
},
{
"cost": "0.62",
"description": "Fortaz-iso-osmot 2 gm/50 ml",
"unit": "ml"
}
] |
[
{
"approved": "2006-09-26",
"country": "United States",
"expires": "2022-02-24",
"number": "7112592"
},
{
"approved": "2012-05-15",
"country": "United States",
"expires": "2021-07-24",
"number": "8178554"
},
{
"approved": "2009-11-03",
"country": "United States",
"expires": "2026-11-12",
"number": "7612087"
},
{
"approved": "2013-06-25",
"country": "United States",
"expires": "2031-08-12",
"number": "8471025"
},
{
"approved": "2014-09-16",
"country": "United States",
"expires": "2030-10-08",
"number": "8835455"
},
{
"approved": "2015-03-03",
"country": "United States",
"expires": "2032-06-15",
"number": "8969566"
},
{
"approved": "2016-03-15",
"country": "United States",
"expires": "2032-06-15",
"number": "9284314"
},
{
"approved": "2017-07-04",
"country": "United States",
"expires": "2032-06-15",
"number": "9695122"
}
] |
CAZ | Ceftazidim | Ceftazidima | Ceftazidime | Ceftazidime anhydrous | Ceftazidimum | 2.4.1.129 | PBP-3 | pbpB | Penicillin-binding protein 3 | Peptidoglycan glycosyltransferase 3 | PBP-1a | ponA | Murein polymerase | PBP-1b | pbpF | ponB | PBP-2 | pbpA | 3.5.2.6 | hOAT1 | hPAHT | hROAT1 | OAT1 | Organic anion transporter 1 | PAH transporter | PAHT | Renal organic anion transporter 1
|
[
"Avycaz",
"Ceftazidime",
"Ceftazidime",
"Ceftazidime",
"Ceftazidime",
"Ceftazidime",
"Ceftazidime",
"Ceftazidime",
"Ceftazidime",
"Ceftazidime",
"Ceftazidime",
"Ceftazidime",
"Ceftazidime",
"Ceftazidime",
"Ceftazidime",
"Ceftazidime",
"Ceftazidime",
"Ceftazidime",
"Ceftazidime and Dextrose",
"Ceftazidime and Dextrose",
"Ceftazidime for Injection BP",
"Ceftazidime for Injection BP",
"Ceftazidime for Injection BP",
"Ceftazidime for Injection, BP",
"Ceftazidime for Injection, USP",
"Ceftazidime for Injection, USP",
"Ceftazidime for Injection, USP",
"Ceptaz Inj 10gm/vial",
"Ceptaz Inj 1gm/vial",
"Ceptaz Inj 2gm/vial",
"Ceptaz Injection - Pws Im IV 1g/vial",
"Ceptaz Injection - Pws IV 10gm/vial",
"Ceptaz Injection - Pws IV 2gm/vial",
"Fortaz",
"Fortaz",
"Fortaz",
"Fortaz",
"Fortaz",
"Fortaz",
"Fortaz",
"Fortaz",
"Fortaz",
"Fortaz",
"Fortaz",
"Fortaz",
"Fortaz",
"Fortaz",
"Fortaz",
"Fortaz",
"Fortaz",
"Fortaz",
"Fortaz",
"Fortaz",
"Fortaz",
"Fortaz",
"Fortaz",
"Fortaz",
"Fortaz",
"Fortaz",
"Fortaz",
"Fortaz",
"Fortaz",
"Fortaz",
"Fortaz",
"Fortaz",
"Fortaz",
"Fortaz",
"Fortaz",
"Fortaz",
"Fortaz Inj 1gm/vial",
"Fortaz Inj 2gm/vial",
"Fortaz Inj 500mg/vial",
"Fortaz Pws Inj 6gm/vial",
"Tazicef",
"Tazicef",
"Tazicef",
"Tazicef",
"Tazicef",
"Tazicef",
"Tazidime Add-vantage Inj 1.0gm/vial",
"Tazidime Add-vantage Inj 2gm/vial",
"Tazidime Inj 500mg/vial",
"Zavicefta"
] |
[
"Cefzim",
"Ceptaz",
"Fortum",
"Tazidime",
"Veltadim"
] |
[
"Avycaz",
"Zavicefta"
] |
[] |
[] |
[
"P02768"
] |
[
"Q4U2R8"
] |
DB00440
|
Trimethoprim
|
Trimethoprim is an antifolate antibacterial agent that inhibits bacterial dihydrofolate reductase (DHFR), a critical enzyme that catalyzes the formation of tetrahydrofolic acid (THF) - in doing so, it prevents the synthesis of bacterial DNA and ultimately continued bacterial survival.[L11893] Trimethoprim is often used in combination with [sulfamethoxazole] due to their complementary and synergistic mechanisms but may be used as a monotherapy in the treatment and/or prophylaxis of urinary tract infections.[L11893,L11830] It is structurally and chemically related to [pyrimethamine], another antifolate antimicrobial used in the treatment of plasmodial infections.[T707]
|
solid
|
As a monotherapy, trimethoprim is indicated for the treatment of acute episodes of uncomplicated urinary tract infections caused by susceptible bacteria, including _E. coli._, _K. pneumoniae_, _Enterobacter spp._, _P. mirabilis_, and coagulase-negative _Staphylococcus_ species.[L11893,L11890] In various formulations in combination with [sulfamethoxazole], trimethoprim is indicated for the following infections caused by bacteria with documented susceptibility: urinary tract infections, acute otitis media in pediatric patients (when clinically indicated), acute exacerbations of chronic bronchitis in adults, enteritis caused by susceptible _Shigella_, prophylaxis and treatment of _Pneumocystis jiroveci_ pneumonia, and travelers' diarrhea caused by enterotoxigenic _E. coli_.[L11830,L11863]
Trimethoprim is available as an ophthalmic solution in combination with [polymyxin B] for the treatment of acute bacterial conjunctivitis, blepharitis, and blepharoconjunctivitis caused by susceptible bacteria.[L11887]
|
Trimethoprim exerts its antimicrobial effects by inhibiting an essential step in the synthesis of bacterial nucleic acids and proteins.[L11893] It has shown activity against several species of gram-negative bacteria, as well as coagulase-negative _Staphylococcus_ species. [L11893] Resistance to trimethoprim may arise via a variety of mechanisms, including alterations to the bacterial cell wall, overproduction of dihydrofolate reductase, or production of resistant dihydrofolate reductase.[L11893] Rarely, trimethoprim can precipitate the development of blood disorders (e.g. thrombocytopenia, leukopenia, etc.) which may be preceded by symptoms such as sore throat, fever, pallor, and or purpura - patients should be monitored closely for the development of these symptoms throught the course of therapy.[L11893]
As antimicrobial susceptibility patterns are geographically distinct, local antibiograms should be consulted to ensure adequate coverage of relevant pathogens prior to use.
|
Trimethoprim is a reversible inhibitor of dihydrofolate reductase, one of the principal enzymes catalyzing the formation of tetrahydrofolic acid (THF) from dihydrofolic acid (DHF).[L11893] Tetrahydrofolic acid is necessary for the biosynthesis of bacterial nucleic acids and proteins and ultimately for continued bacterial survival - inhibiting its synthesis, then, results in bactericidal activity. Trimethoprim binds with a much stronger affinity to bacterial dihydrofolate reductase as compared to its mammalian counterpart, allowing trimethoprim to selectively interfere with bacterial biosynthetic processes.[L11893]
Trimethoprim is often given in combination with sulfamethoxazole, which inhibits the preceding step in bacterial protein synthesis - given together, sulfamethoxazole and trimethoprim inhibit two consecutive steps in the biosynthesis of bacterial nucleic acids and proteins.[L11830] As a monotherapy trimethoprim is considered bacteriostatic, but in combination with sulfamethoxazole is thought to exert bactericidal activity.[L11887,A191089]
|
Steady-state concentrations are achieved after approximately 3 days of repeat administration.[A191368] Average peak serum concentrations of approximately 1 µg/mL (C<sub>max</sub>) are achieved within 1 to 4 hours (T<sub>max</sub>) following the administration of a single 100mg dose.[L11893] Trimethoprim appears to follow first-order pharmacokinetics,[A191368] as a single 200mg dose results in serum concentrations approximately double that of a 100mg dose.[L11893] The steady-state AUC of orally administered trimethoprim is approximately 30 mg/L·h.[A191368]
|
Trimethoprim undergoes oxidative metabolism to a number of metabolites, the most abundant of which are the demethylated 3'- and 4'- metabolites, accounting for approximately 65% and 25% of the total metabolite formation, respectively.[A191149] Minor products include N-oxide metabolites (<5%) and benzylic metabolites in even smaller quantities.[A191149] The parent drug is considered to be the therapeutically active form.[L11893]
The majority of trimethoprim biotransformation appears to involve CYP2C9 and CYP3A4 enzymes, with CYP1A2 contributing to a lesser extent.[A191149]
|
The oral LD<sub>50</sub> in mice and rats is 2764 mg/kg and >5300 mg/kg, respectively.[L11917]
Prescribing information for trimethoprim states that signs of overdose may be evident following ingestion of doses >1 gram, and may include nausea, vomiting, dizziness, headaches, mental depression, confusion, and bone marrow depression.[L11893] Treatment should consist of general supportive measures and gastric lavage, if applicable. Urinary acidification may increase renal elimination of trimethoprim. Hemodialysis is only moderately effective in eliminating trimethoprim and peritoneal dialysis is of no benefit.[L11893]
|
Trimethoprim half-life ranges from 8-10 hours, but may be prolonged in patients with renal dysfunction.[L11890]
|
Trimethoprim is 44% bound to plasma proteins, though the specific proteins to which it binds have not been elucidated.[L11890]
|
Approximately 10-20% of an ingested trimethoprim dose is metabolized, primarily in the liver, while a large portion of the remainder is excreted unchanged in the urine.[L11893] Following oral administration, 50% to 60% of trimethoprim is excreted in the urine within 24 hours, approximately 80% of which is unchanged parent drug.[L11890]
|
Trimethoprim is extensively distributed into various tissues following oral administration. It distributes well into sputum, middle ear fluid, and bronchial secretions.[L11830] Trimethoprim distributes efficiently into vaginal fluids, with observed concentrations approximately 1.6-fold higher than those seen in the serum.[L11893] It may pass the placental barrier and into breast milk.[L11830] Trimethoprim is also sufficiently excreted in the feces to markedly reduce and/or eliminate trimethoprim-susceptible fecal flora.[L11893]
|
Following oral administration, the renal clearance of trimethoprim has been variably reported between 51.7 - 91.3 mL/min.[A191368]
|
Organic compounds
|
Benzenoids
|
Phenol ethers
|
Anisoles
|
[
"approved",
"vet_approved"
] |
[
"J01EE",
"J01E",
"J01",
"J",
"J01EA",
"J01E",
"J01",
"J",
"J04AM",
"J04A",
"J04",
"J",
"J01EE",
"J01E",
"J01",
"J",
"J01EE",
"J01E",
"J01",
"J",
"J01EE",
"J01E",
"J01",
"J",
"J01EE",
"J01E",
"J01",
"J",
"J01EE",
"J01E",
"J01",
"J"
] |
[
"Staphylococcus saprophyticus",
"Enterobacter spp.",
"Escherichia coli",
"Klebsiella pneumoniae",
"Proteus mirabilis"
] |
[
{
"cost": "1.44",
"description": "Sulfamethoxazole-tmp ds tablet",
"unit": "tablet"
},
{
"cost": "1.49",
"description": "Septra 80-400 tablet",
"unit": "tablet"
},
{
"cost": "1.63",
"description": "Bactrim 400-80 mg tablet",
"unit": "tablet"
},
{
"cost": "1.79",
"description": "Trimethoprim powder",
"unit": "g"
},
{
"cost": "2.33",
"description": "Septra ds tablet",
"unit": "tablet"
},
{
"cost": "2.43",
"description": "Septra DS 800-160 mg tablet",
"unit": "tablet"
},
{
"cost": "3.0",
"description": "Bactrim DS 800-160 mg tablet",
"unit": "tablet"
},
{
"cost": "5.53",
"description": "Bactrim ds tablet",
"unit": "tablet"
},
{
"cost": "0.13",
"description": "Sulfamethoxazole-Trimethoprim 200-40 mg/5ml Suspension",
"unit": "ml"
},
{
"cost": "0.13",
"description": "Sulfatrim 200-40 mg/5ml Suspension",
"unit": "ml"
},
{
"cost": "0.17",
"description": "Sulfamethoxazole-tmp ss tablet",
"unit": "tablet"
},
{
"cost": "0.27",
"description": "Apo-Trimethoprim 100 mg Tablet",
"unit": "tablet"
},
{
"cost": "0.39",
"description": "Primsol 50 mg/5 ml oral soln",
"unit": "ml"
},
{
"cost": "0.55",
"description": "Apo-Trimethoprim 200 mg Tablet",
"unit": "tablet"
},
{
"cost": "0.69",
"description": "Sulfamethoxazole-Trimethoprim 400-80 mg tablet",
"unit": "tablet"
},
{
"cost": "0.7",
"description": "Trimethoprim 100 mg tablet",
"unit": "tablet"
},
{
"cost": "0.84",
"description": "Sulfamethoxazole-tmp vial",
"unit": "ml"
}
] |
[
{
"approved": "1999-10-05",
"country": "United States",
"expires": "2016-08-07",
"number": "5962461"
},
{
"approved": "1998-06-09",
"country": "United States",
"expires": "2016-08-07",
"number": "5763449"
}
] |
2,4-diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine | 5-[(3,4,5-trimethoxyphenyl)methyl]-2,4-pyrimidinediamine | Trimethoprim | Triméthoprime | Trimethoprimum | Trimetoprima | 1.5.1.3 | 1.5.1.3 | tmrA | (R)-limonene 6-monooxygenase | (S)-limonene 6-monooxygenase | (S)-limonene 7-monooxygenase | 1.14.14.1 | Cholesterol 25-hydroxylase | CYP2C10 | CYPIIC9 | Cytochrome P-450MP | Cytochrome P450 MP-4 | Cytochrome P450 MP-8 | Cytochrome P450 PB-1 | S-mephenytoin 4-hydroxylase | 1,4-cineole 2-exo-monooxygenase | 1,8-cineole 2-exo-monooxygenase | 1.14.14.1 | Albendazole monooxygenase (sulfoxide-forming) | Albendazole sulfoxidase | Cholesterol 25-hydroxylase | CYP3A3 | CYPIIIA3 | CYPIIIA4 | Cytochrome P450 3A3 | Cytochrome P450 HLp | Cytochrome P450 NF-25 | Cytochrome P450-PCN1 | Nifedipine oxidase | Quinine 3-monooxygenase | 1.14.14.1 | Cholesterol 25-hydroxylase | CYPIA2 | Cytochrome P(3)450 | Cytochrome P450 4 | Cytochrome P450-P3 | Hydroperoxy icosatetraenoate dehydratase | 1.14.14.1 | CYPIIC8 | Cytochrome P450 form 1 | Cytochrome P450 IIC2 | Cytochrome P450 MP-12 | Cytochrome P450 MP-20 | S-mephenytoin 4-hydroxylase | ATP-binding cassette sub-family B member 1 | MDR1 | Multidrug resistance protein 1 | P-glycoprotein 1 | PGY1 | Phospholipid transporter ABCB1 | hMATE-1 | MATE-1 | MATE1 | Solute carrier family 47 member 1 | hMATE-2 | Kidney-specific H(+)/organic cation antiporter | MATE-2 | MATE2 | Solute carrier family 47 member 2
|
[
"Apo-sulfatrim Oral Suspension",
"Bactrim",
"Bactrim",
"Bactrim DS",
"Bactrim DS",
"Bactrim DS",
"Bactrim DS",
"Bactrim DS Roche Tab",
"Bactrim Roche Inj",
"Bactrim Roche Suspension Paediatric",
"Bactrim Roche Tab",
"Coptin Oral Suspension",
"Coptin Tab",
"Coptin Tab",
"Nu-cotrimox Sus 40/8mg/ml",
"Nu-cotrimox Tab 400/80mg",
"Nu-cotrimox-DS Tab 800/160mg",
"PMS-polytrimethoprim",
"Polymyxin B Sulfate and Trimethoprim",
"Polymyxin B Sulfate and Trimethoprim",
"Polymyxin B Sulfate and Trimethoprim",
"Polymyxin B Sulfate and Trimethoprim",
"Polymyxin B Sulfate and Trimethoprim",
"Polymyxin B Sulfate and Trimethoprim",
"Polymyxin B Sulfate and Trimethoprim",
"Polymyxin B Sulfate and Trimethoprim",
"Polymyxin B Sulfate and Trimethoprim",
"Polymyxin B Sulfate and Trimethoprim",
"Polymyxin B Sulfate and Trimethoprim",
"Polymyxin B Sulfate and Trimethoprim",
"Polymyxin B Sulfate and Trimethoprim",
"Polymyxin B Sulfate and Trimethoprim",
"Polymyxin B Sulfate and Trimethoprim",
"Polymyxin B Sulfate and Trimethoprim",
"Polymyxin B Sulfate and Trimethoprim",
"Polymyxin B Sulfate and Trimethoprim",
"Polymyxin B Sulfate and Trimethoprim",
"Polymyxin B Sulfate and Trimethoprim",
"Polymyxin B Sulfate and Trimethoprim",
"Polymyxin B Sulfate and Trimethoprim",
"Polymyxin B Sulfate and Trimethoprim",
"Polymyxin B Sulfate and Trimethoprim",
"Polymyxin B Sulfate and Trimethoprim",
"Polymyxin B Sulfate and Trimethoprim",
"Polymyxin B Sulfate and Trimethoprim",
"POLYMYXIN B SULFATE and TRIMETHOPRIM SULFATE",
"POLYMYXIN B SULFATE and TRIMETHOPRIM SULFATE",
"POLYMYXIN B SULFATE and TRIMETHOPRIM SULFATE",
"POLYMYXIN B SULFATE and TRIMETHOPRIM SULFATE",
"POLYMYXIN B SULFATE and TRIMETHOPRIM SULFATE",
"Polymyxin B Sulfate and Trimethoprim Sulfate",
"POLYMYXIN B SULFATE and TRIMETHOPRIM SULFATE",
"POLYMYXIN B SULFATE and TRIMETHOPRIM SULFATE",
"POLYMYXIN B SULFATE and TRIMETHOPRIM SULFATE",
"Polymyxin B Sulfate and Trimethoprim Sulfate",
"POLYMYXIN B SULFATE and TRIMETHOPRIM SULFATE",
"Polytrim",
"Polytrim",
"Polytrim",
"Polytrim",
"Polytrim Ophthalmic Solution",
"Primsol",
"Primsol",
"PrimSol",
"Proloprim",
"Proloprim",
"Proloprim 200 Tab 200mg",
"Proloprim Tab 100mg",
"Protrin Df Tab",
"Protrin Tab",
"Riva-sep DS",
"Roubac Tab 160/800",
"Roubac Tab 80/400",
"Sandoz Polytrimethoprim",
"Septra",
"Septra",
"Septra",
"Septra",
"Septra DS",
"Septra DS Tablets",
"Septra Grape",
"Septra Injection",
"Septra Pediatric Suspension",
"Sulfameth/Trimeth-DS",
"Sulfamethox-TMP DS",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"SULFAMETHOXAZOLE and TRIMETHOPRIM",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
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"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim (Double Strength)",
"SULFAMETHOXAZOLE AND TRIMETHOPRIM double strength",
"Sulfamethoxazole and Trimethoprim Double Strength",
"Sulfamethoxazole and Trimethoprim DS",
"Sulfamethoxazole and Trimethoprim DS",
"Sulfamethoxazole and Trimethoprim DS",
"Sulfamethoxazole and Trimethoprim DS",
"Sulfamethoxazole and Trimethoprim for Injection, USP",
"Sulfamethoxazole and Trimethoprim for Injection, USP",
"Sulfamethoxazole and Trimethoprim Injection, BP",
"Sulfamethoxazole and Trimethoprim Tablets",
"Sulfamethoxazole and Trimethoprim Tablets",
"sulfamethoxazole-trimethoprim (SMZ)",
"sulfamethoxazole-trimethoprim (SMZ)",
"Sulfatrim",
"Sulfatrim",
"Sulfatrim",
"Sulfatrim",
"Sulfatrim",
"Sulfatrim",
"Sulfatrim",
"Sulfatrim",
"Sulfatrim",
"Sulfatrim",
"Sulfatrim DS",
"Sulfatrim Pediatric",
"SulfatrimTM Pediatric Suspension",
"Teva-trimel",
"Teva-trimel",
"Teva-trimel DS",
"Trimethoprim",
"Trimethoprim",
"Trimethoprim",
"Trimethoprim",
"Trimethoprim",
"Trimethoprim",
"Trimethoprim",
"Trimethoprim",
"Trimethoprim",
"Trimethoprim",
"Trimethoprim",
"Trimethoprim",
"Trimethoprim",
"Trimethoprim",
"Trimethoprim",
"Trimethoprim",
"Trimethoprim",
"Trimethoprim",
"Trimethoprim sulfate and Polymyxin B sulfate",
"Trimethoprim sulfate and Polymyxin B sulfate",
"Trimethoprim sulfate and Polymyxin B sulfate",
"Trimethoprim sulfate and Polymyxin B sulfate",
"Trimethoprim sulfate and Polymyxin B sulfate",
"Trimethoprim Tablets",
"Trimethoprim Tablets",
"TRIMPEX trimethoprim hydrochloride",
"Trisulfa DS Tab",
"Trisulfa S Suspension",
"Trisulfa Tab"
] |
[
"Alprim",
"Catin",
"Eumi",
"Inflamnil",
"Lannacher",
"Lariago",
"Meprim",
"Metipine",
"Monotrim",
"Motrim",
"Trimpex",
"Triprim"
] |
[
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"SULFAMETHOXAZOLE and TRIMETHOPRIM",
"Polymyxin B Sulfate and Trimethoprim",
"Bactrim DS",
"Sulfamethoxazole and Trimethoprim DS",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Polymyxin B Sulfate and Trimethoprim",
"sulfamethoxazole-trimethoprim (SMZ)",
"sulfamethoxazole-trimethoprim (SMZ)",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"POLYMYXIN B SULFATE and TRIMETHOPRIM SULFATE",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Polytrim",
"Sulfamethoxazole and Trimethoprim",
"SULFAMETHOXAZOLE AND TRIMETHOPRIM double strength",
"Sulfamethoxazole and Trimethoprim",
"Polymyxin B Sulfate and Trimethoprim",
"Polytrim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Septra",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Polymyxin B Sulfate and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfatrim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"POLYMYXIN B SULFATE and TRIMETHOPRIM SULFATE",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim (Double Strength)",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim Double Strength",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"POLYMYXIN B SULFATE and TRIMETHOPRIM SULFATE",
"Sulfamethoxazole and Trimethoprim",
"Sulfatrim",
"Sulfatrim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Polymyxin B Sulfate and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Polymyxin B Sulfate and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Polymyxin B Sulfate and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Bactrim DS",
"Bactrim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Septra",
"Septra Grape",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Polymyxin B Sulfate and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"POLYMYXIN B SULFATE and TRIMETHOPRIM SULFATE",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Trimethoprim sulfate and Polymyxin B sulfate",
"Polymyxin B Sulfate and Trimethoprim",
"POLYMYXIN B SULFATE and TRIMETHOPRIM SULFATE",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Polymyxin B Sulfate and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfatrim",
"Sulfamethoxazole and Trimethoprim",
"Polymyxin B Sulfate and Trimethoprim",
"Polymyxin B Sulfate and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Trimethoprim sulfate and Polymyxin B sulfate",
"Polytrim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Polymyxin B Sulfate and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethox-TMP DS",
"Sulfatrim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Polymyxin B Sulfate and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfameth/Trimeth-DS",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Polymyxin B Sulfate and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Polymyxin B Sulfate and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfatrim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Polymyxin B Sulfate and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Polymyxin B Sulfate and Trimethoprim Sulfate",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Polymyxin B Sulfate and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Polymyxin B Sulfate and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Polymyxin B Sulfate and Trimethoprim",
"Trimethoprim sulfate and Polymyxin B sulfate",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Polymyxin B Sulfate and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Polymyxin B Sulfate and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfatrim",
"Polytrim",
"Septra",
"Septra DS",
"Polymyxin B Sulfate and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"POLYMYXIN B SULFATE and TRIMETHOPRIM SULFATE",
"Trimethoprim sulfate and Polymyxin B sulfate",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"POLYMYXIN B SULFATE and TRIMETHOPRIM SULFATE",
"Trimethoprim sulfate and Polymyxin B sulfate",
"Sulfamethoxazole and Trimethoprim",
"Polymyxin B Sulfate and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Polymyxin B Sulfate and Trimethoprim",
"Bactrim DS",
"Bactrim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfatrim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim DS",
"Sulfamethoxazole and Trimethoprim DS",
"Sulfamethoxazole and Trimethoprim DS",
"Sulfatrim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"POLYMYXIN B SULFATE and TRIMETHOPRIM SULFATE",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfatrim Pediatric",
"Sulfatrim",
"Sulfatrim DS",
"Teva-trimel DS",
"Teva-trimel",
"Teva-trimel",
"Trisulfa Tab",
"Trisulfa DS Tab",
"Trisulfa S Suspension",
"Nu-cotrimox Tab 400/80mg",
"Nu-cotrimox-DS Tab 800/160mg",
"Nu-cotrimox Sus 40/8mg/ml",
"Septra",
"Septra Pediatric Suspension",
"Bactrim Roche Suspension Paediatric",
"Bactrim Roche Tab",
"Septra DS Tablets",
"Bactrim DS Roche Tab",
"Coptin Tab",
"Sulfamethoxazole and Trimethoprim Tablets",
"Sulfamethoxazole and Trimethoprim Tablets",
"Bactrim Roche Inj",
"Roubac Tab 80/400",
"Roubac Tab 160/800",
"Protrin Tab",
"Riva-sep DS",
"Coptin Tab",
"Coptin Oral Suspension",
"Apo-sulfatrim Oral Suspension",
"Protrin Df Tab",
"Septra Injection",
"Polytrim Ophthalmic Solution",
"Sandoz Polytrimethoprim",
"PMS-polytrimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Polymyxin B Sulfate and Trimethoprim",
"Sulfamethoxazole and Trimethoprim for Injection, USP",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim Injection, BP",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim for Injection, USP",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Bactrim DS",
"Sulfamethoxazole and Trimethoprim",
"SulfatrimTM Pediatric Suspension",
"Polymyxin B Sulfate and Trimethoprim",
"Polymyxin B Sulfate and Trimethoprim Sulfate",
"POLYMYXIN B SULFATE and TRIMETHOPRIM SULFATE",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim",
"Sulfamethoxazole and Trimethoprim"
] |
[
"P00374"
] |
[
"P11712",
"P08684",
"P05177",
"P10632"
] |
[] |
[
"P08183",
"Q96FL8",
"Q86VL8"
] |
DB00441
|
Gemcitabine
|
Gemcitabine is a nucleoside analog and a chemotherapeutic agent. It was originally investigated for its antiviral effects, but it is now used as an anticancer therapy for various cancers.[A233135] Gemcitabine is a cytidine analog with two fluorine atoms replacing the hydroxyl on the ribose.[A233145] As a prodrug, gemcitabine is transformed into its active metabolites that work by replacing the building blocks of nucleic acids during DNA elongation, arresting tumour growth and promoting apoptosis of malignant cells.[L32960] The structure, metabolism, and mechanism of action of gemcitabine are similar to [cytarabine], but gemcitabine has a wider spectrum of antitumour activity.[A233140]
Gemcitabine is marketed as Gemzar and it is available as intravenous injection. It is approved by the FDA to treat advanced ovarian cancer in combination with [carboplatin], metastatic breast cancer in combination with [paclitaxel], non-small cell lung cancer in combination with [cisplatin], and pancreatic cancer as monotherapy.[L32950] It is also being investigated in other cancer and tumour types.
|
solid
|
Gemcitabine is a chemotherapeutic agent used as monotherapy or in combination with other anticancer agents.
In combination with [carboplatin], it is indicated for the treatment of advanced ovarian cancer that has relapsed at least 6 months after completion of platinum-based therapy.[L32950]
Gemcitabine in combination with [paclitaxel] is indicated for the first-line treatment of patients with metastatic breast cancer after failure of prior anthracycline-containing adjuvant chemotherapy, unless anthracyclines were clinically contraindicated.[L32950]
In combination with [cisplatin], gemcitabine is indicated for the first-line treatment of patients with inoperable, locally advanced (Stage IIIA or IIIB) or metastatic (Stage IV) non-small cell lung cancer (NSCLC).[L32950] Dual therapy with cisplatin is also used to treat patients with Stage IV (locally advanced or metastatic) transitional cell carcinoma (TCC) of the bladder.[L32955]
Gemcitabine is indicated as first-line treatment for patients with locally advanced (nonresectable Stage II or Stage III) or metastatic (Stage IV) adenocarcinoma of the pancreas. Gemcitabine is indicated for patients previously treated with [fluorouracil].[L32950]
|
Gemcitabine is a nucleoside analog that mediates its antitumour effects by promoting apoptosis of malignant cells undergoing DNA synthesis. More specifically, it blocks the progression of cells through the G1/S-phase boundary.[L32950] Gemcitabine demonstrated cytotoxic effects against a broad range of cancer cell lines _in vitro_. It displayed schedule-dependent antitumour activity in various animal models and xenografts from human non-small cell lung cancer (NSCLC) and pancreatic cancer.[A233140] Therefore, the antineoplastic effects of gemcitabine are enhanced through prolonged infusion time rather than higher dosage.[A233140] Gemcitabine inhibited the growth of human xenografts from carcinoma of the lung, pancreas, ovaries, head and neck, and breast. In mice, gemcitabine inhibited the growth of human tumour xenografts from the breast, colon, lung or pancreas by 69 to 99%. In clinical trials of advanced NSCLC, gemcitabine monotherapy produced objective response rates ranging from 18 to 26%, with a median duration of response ranging from 3.3 to 12.7 months. Overall median survival time was 6.2 to 12.3 months. The combined use of cisplatin and gemcitabine produced better objective response rates compared to monotherapy. In patients with advanced pancreatic cancer, objective response rates in patients ranged from 5.to 12%, with a median survival duration of 3.9 to 6.3 months.[A233145] In Phase II trials involving patients with metastatic breast cancer, treatment with gemcitabine alone or with adjuvant chemotherapies resulted in response rate ranging from 13 to 42% and median survival duration ranging from 11.5 to 17.8 months. In metastatic bladder cancer, gemcitabine has a response rate 20 to 28%. In Phase II trials of advanced ovarian cancer, patients treated with gemcitabine had response rate of 57.1%, with progression free survival of 13.4 months and median survival of 24 months.[A233140]
Gemcitabine causes dose-limiting myelosuppression, such as anemia, leukopenia, neutropenia, and thrombocytopenia; however, events leading to discontinuation tend to occur less than 1% of the patients. Gemcitabine can elevate ALT, AST and alkaline phosphatase levels.[A233145]
|
Gemcitabine is a potent and specific deoxycytidine analog. After uptake into malignant cells, gemcitabine is phosphorylated by deoxycytidine kinase to form gemcitabine monophosphate, which is then converted to the active compounds, gemcitabine diphosphate (dFdCDP) and gemcitabine triphosphate (dFdCTP). These active metabolites are nucleosides that mediate antitumour effects. dFdCTP competes with deoxycytidine triphosphate (dCTP) for incorporation into DNA, thereby competitively inhibiting DNA chain elongation. The non-terminal position of dFdCTP in the DNA chain prevents detection of dFdCTP in the chain and repair by proof-reading 3′5′-exonuclease: this process is referred to as "masked DNA chain termination." Incorporation of dFdCTP into the DNA chain ultimately leads to chain termination, DNA fragmentation, and apoptotic cell death of malignant cells.[A233140,A233145,L32950]
Gemcitabine has self-potentiating pharmacological actions that can increase the probability of successful incorporation of gemcitabine triphosphate into the DNA chain: dFdCDP inhibits ribonucleotide reductase, an enzyme responsible for catalyzing the reactions that generate dCTP for DNA synthesis. Since dFdCDP reduces the levels of dCTP, there is less competition for gemcitabine triphosphate for incorporation into DNA.[A233140,L32950] Gemcitabine can also reduce metabolism and elimination of active metabolites from the target ce1l, prolonging high intracellular concentrations of the active metabolites. Such self-potentiating effects are not present with [cytarabine].[A233140]
|
Peak plasma concentrations of gemcitabine range from 10 to 40 mg/L following a 30-minute intravenous infusion, and are reached at 15 to 30 minutes. One study showed that steady-state concentrations of gemcitabine showed a linear relationship to dose over the dose range 53 to 1000 mg/m<sup>2</sup>. Gemcitabine triphosphate, the active metabolite of gemcitabine, can accumulate in circulating peripheral blood mononuclear cells. In one study, the C<sub>max</sub> of gemcitabine triphosphate in peripheral blood mononuclear cells occurred within 30 minutes of the end of the infusion period and increased increased proportionally with gemcitabine doses of up to 350 mg/m<sup>2</sup>.[A233140]
|
Following administration and uptake into cancer cells, gemcitabine is initially phosphorylated by deoxycytidine kinase (dCK), and to a lower extent, the extra-mitochondrial thymidine kinase 2 to form gemcitabine monophosphate (dFdCMP). dFdCMP is subsequently phosphorylated by nucleoside kinases to form active metabolites, gemcitabine diphosphate (dFdCDP) and gemcitabine triphosphate (dFdCTP).[A233145] Gemcitabine is also deaminated intracellularly and extracellularly by cytidine deaminase to its inactive metabolite 2′,2′-difluorodeoxyuridine or 2´-deoxy-2´,2´-difluorouridine (dFdU). Deamination occurs in the blood, liver, kidneys, and other tissues,[A233135] and this metabolic pathway accounts for most of drug clearance.[A233145,L32960]
|
The oral LD<sub>50</sub> is 333 mg/kg in mice and >500 mg/kg in rats. The dermal LD<sub>50</sub> in rabbits is >1000 mg/kg.[L33005]
There is no known antidote for gemcitabine overdose. In a dose-escalation study, patients were administered a single dose of gemcitabine as high as 5700 mg/m<sup>2</sup> administered by intravenous infusion over 30 minutes every two weeks: main observed toxicities were myelosuppression, paresthesia, and severe rash. In the event of a suspected drug overdose, blood counts should be monitored, and patients should be provided with supportive therapy, as necessary.[L32950]
|
Following intravenous infusions lasting less than 70 minutes, the terminal half-life ranged from 0.7 to 1.6 hours. Following infusions ranging from 70 to 285 minutes, the terminal half-life ranged from 4.1 to 10.6 hours.[L32960] Females tend to have longer half-lives than male patients. Gemcitabine triphosphate, the active metabolite of gemcitabine, can accumulate in circulating peripheral blood mononuclear cells. The terminal half-life of gemcitabine triphosphate, the active metabolite, from mononuclear cells ranges from 1.7 to 19.4 hours.[L32950]
|
Gemcitabine plasma protein binding is less than 10%.[L32960]
|
Gemcitabine mainly undergoes renal excretion. Within a week following administration of a single dose of 1000 mg/m<sup>2</sup> infused over 30 minutes, about 92-98% of the dose was recovered in urine where 89% of the recovered dose was excreted as difluorodeoxyuridine (dFdU) and less than 10% as gemcitabine.[L32950] Monophosphate, diphosphate, or triphosphate metabolites of gemcitabine are not detectable in urine. In a single-dose study, about 1% of the administered dose was recovered in the feces.[A233135]
|
In patients with various solid tumours, the volume of distribution increased with infusion length. The volume of distribution of gemcitabine was 50 L/m<sup>2</sup> following infusions lasting less than 70 minutes. For long infusions, the volume of distribution rose to 370 L/m<sup>2</sup>.[L32950]
Gemcitabine triphosphate, the active metabolite of gemcitabine, accumulates and retains in solid tumour cells _in vitro_ and _in vivo_. It is not extensively distributed to tissues after short infusions that last less than 70 minutes.[A233140] It is not known whether gemcitabine crosses the blood-brain barrier, but gemcitabine is widely distributed into tissues, including ascitic fluid.[L32960] In rats, placental and lacteal transfer occurred rapidly at five to 15 minutes following drug administration.[A233135]
|
Following intravenous infusions lasting less than 70 minutes, clearance ranged from 41 to 92 L/h/m<sup>2</sup> in males and ranged from 31 to 69 L/h/m<sup>2</sup> in females.[L32960] Clearance decreases with age. Females have about 30% lower clearance than male patients.[L32950]
|
Organic compounds
|
Nucleosides, nucleotides, and analogues
|
Pyrimidine nucleosides
|
Pyrimidine 2'-deoxyribonucleosides
|
[
"approved"
] |
[
"L01BC",
"L01B",
"L01",
"L"
] |
[
"Humans and other mammals"
] |
[
{
"cost": "180.78",
"description": "Gemzar 200 mg Solution Vial",
"unit": "vial"
},
{
"cost": "869.16",
"description": "Gemzar 1 gram vial",
"unit": "vial"
},
{
"cost": "903.93",
"description": "Gemzar 1 gm Solution Vial",
"unit": "vial"
}
] |
[
{
"approved": "1995-11-07",
"country": "United States",
"expires": "2013-05-07",
"number": "5464826"
},
{
"approved": "1989-02-28",
"country": "United States",
"expires": "2010-05-15",
"number": "4808614"
},
{
"approved": "2016-01-26",
"country": "United States",
"expires": "2033-07-01",
"number": "9241948"
}
] |
2'-Deoxy-2',2'-difluorocytidine | 2',2'-Difluorodeoxycytidine | 4-amino-1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)pyrimidin-2(1H)-one | Gemcitabin | Gemcitabina | Gemcitabine | Gemcitabinum | 1.17.4.1 | Ribonucleotide reductase small chain | Ribonucleotide reductase small subunit | RR2 | 1.17.4.1 | Ribonucleoside-diphosphate reductase subunit M1 | Ribonucleotide reductase large subunit | RR1 | 2.1.1.45 | TS | TSase | 2.7.4.14 | CK | CMK | CMPK | dCMP kinase | Deoxycytidylate kinase | Nucleoside-diphosphate kinase | UCK | UMK | UMP/CMP kinase | UMP/CMPK | UMPK | Uridine monophosphate/cytidine monophosphate kinase | 2.7.1.21 | 2'-deoxyuridine kinase TK2 | Deoxycytidine kinase TK2 | Mt-TK | 2.7.4.14 | CK | CMK | CMPK | dCMP kinase | Deoxycytidylate kinase | Nucleoside-diphosphate kinase | UCK | UMK | UMP/CMP kinase | UMP/CMPK | UMPK | Uridine monophosphate/cytidine monophosphate kinase | 2.7.4.6 | GAAD | Granzyme A-activated DNase | Metastasis inhibition factor nm23 | NDK A | NDP kinase A | NDPKA | NM23 | NM23-H1 | Tumor metastatic process-associated protein | 3.5.4.5 | CDD | Cytidine aminohydrolase | 2.7.1.74 | dCK | Deoxyadenosine kinase | Deoxyguanosine kinase | ATP-binding cassette sub-family B member 1 | MDR1 | Multidrug resistance protein 1 | P-glycoprotein 1 | PGY1 | Phospholipid transporter ABCB1 | 7.6.2.2 | 7.6.2.3 | MRP7 | Multidrug resistance-associated protein 7 | SIMRP7 | ENT1 | Equilibrative NBMPR-sensitive nucleoside transporter | Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter | es nucleoside transporter | hENT1 | Nucleoside transporter, es-type | Solute carrier family 29 member 1 | CNT 1 | CNT1 | Concentrative nucleoside transporter 1 | hCNT1 | Na(+)/nucleoside cotransporter 1 | Sodium-coupled nucleoside transporter 1 | Solute carrier family 28 member 1 | 36 kDa nucleolar protein HNP36 | Delayed-early response protein 12 | DER12 | ENT2 | Equilibrative NBMPR-insensitive nucleoside transporter | Equilibrative nitrobenzylmercaptopurine riboside-insensitive nucleoside transporter | hENT2 | HNP36 | Hydrophobic nucleolar protein, 36 kDa | Nucleoside transporter, ei-type | Solute carrier family 29 member 2 | CNT 3 | CNT3 | Concentrative Na(+)-nucleoside cotransporter 3 | hCNT3
|
[
"Act Gemcitabine",
"Act Gemcitabine",
"Act Gemcitabine",
"Aj-gemcitabine",
"Aj-gemcitabine",
"Aj-gemcitabine",
"Gemcitabine",
"Gemcitabine",
"Gemcitabine",
"Gemcitabine",
"Gemcitabine",
"Gemcitabine",
"Gemcitabine",
"Gemcitabine",
"Gemcitabine",
"Gemcitabine",
"Gemcitabine",
"Gemcitabine",
"Gemcitabine",
"Gemcitabine",
"Gemcitabine",
"Gemcitabine",
"Gemcitabine",
"Gemcitabine",
"Gemcitabine",
"Gemcitabine",
"Gemcitabine",
"Gemcitabine",
"Gemcitabine",
"Gemcitabine",
"Gemcitabine",
"Gemcitabine",
"Gemcitabine",
"Gemcitabine",
"Gemcitabine",
"Gemcitabine",
"Gemcitabine",
"Gemcitabine",
"Gemcitabine",
"Gemcitabine",
"Gemcitabine",
"Gemcitabine",
"Gemcitabine",
"Gemcitabine",
"Gemcitabine",
"Gemcitabine",
"Gemcitabine",
"Gemcitabine",
"Gemcitabine",
"Gemcitabine",
"Gemcitabine",
"Gemcitabine",
"Gemcitabine",
"Gemcitabine",
"Gemcitabine",
"Gemcitabine",
"Gemcitabine",
"Gemcitabine",
"Gemcitabine",
"Gemcitabine",
"Gemcitabine",
"Gemcitabine",
"Gemcitabine",
"Gemcitabine",
"Gemcitabine for Injection",
"Gemcitabine for Injection",
"Gemcitabine for Injection",
"Gemcitabine for Injection",
"Gemcitabine for Injection",
"Gemcitabine for Injection",
"Gemcitabine for Injection",
"Gemcitabine for Injection",
"Gemcitabine for Injection",
"Gemcitabine for Injection",
"Gemcitabine for Injection Concentrate",
"Gemcitabine for Injection USP",
"Gemcitabine for Injection USP",
"Gemcitabine for Injection, USP",
"Gemcitabine for Injection, USP",
"Gemcitabine for Injection, USP",
"Gemcitabine for Injection, USP",
"Gemcitabine for Injection, USP",
"Gemcitabine for Injection, USP",
"Gemcitabine for Injection, USP",
"Gemcitabine for Injection, USP",
"Gemcitabine for Injection, USP",
"Gemcitabine HCl",
"Gemcitabine HCl",
"Gemcitabine HCl",
"Gemcitabine HCl",
"Gemcitabine Hydrochloride",
"Gemcitabine Hydrochloride",
"Gemcitabine Hydrochloride",
"Gemcitabine Hydrochloride",
"Gemcitabine Hydrochloride",
"Gemcitabine Hydrochloride",
"Gemcitabine Hydrochloride",
"Gemcitabine Hydrochloride",
"Gemcitabine Hydrochloride",
"Gemcitabine Hydrochloride",
"Gemcitabine Hydrochloride",
"Gemcitabine hydrochloride",
"Gemcitabine hydrochloride",
"Gemcitabine Hydrochloride",
"Gemcitabine Hydrochloride",
"Gemcitabine Hydrochloride",
"Gemcitabine Hydrochloride",
"Gemcitabine Hydrochloride",
"Gemcitabine Hydrochloride",
"Gemcitabine Hydrochloride",
"Gemcitabine Hydrochloride",
"Gemcitabine hydrochloride",
"Gemcitabine hydrochloride",
"Gemcitabine Hydrochloride",
"Gemcitabine Hydrochloride",
"Gemcitabine hydrochloride",
"Gemcitabine hydrochloride",
"Gemcitabine hydrochloride",
"Gemcitabine Hydrochloride for Injection",
"Gemcitabine Hydrochloride for Injection",
"Gemcitabine Injection",
"Gemcitabine Injection",
"Gemcitabine Injection",
"Gemcitabine Sun for Injection",
"Gemcitabine Sun for Injection",
"Gemzar",
"Gemzar",
"Gemzar (1gm/vial)",
"Gemzar (200mg/vial)",
"Infugem",
"Infugem",
"Infugem",
"Infugem",
"Infugem",
"Infugem",
"Infugem",
"Infugem",
"Infugem",
"Infugem"
] |
[
"Abine",
"Abingem",
"Acytabin",
"Celgem",
"Celzar",
"Cytogem",
"Daplax",
"Dercin",
"Eriogem",
"Fotinex",
"Gebina",
"Gembio",
"Gemcired",
"Gemita",
"Gezt",
"Gitrabin",
"Gramagen",
"Jemta",
"Nallian",
"Oncogem",
"Ribozar",
"Tabin",
"Xtroz"
] |
[] |
[
"P31350",
"P23921",
"P04818",
"P30085"
] |
[
"O00142",
"P30085",
"P15531",
"P32320",
"P27707"
] |
[] |
[
"P08183",
"Q5T3U5",
"Q99808",
"O00337",
"Q14542",
"Q9HAS3"
] |
DB00442
|
Entecavir
|
Entecavir is an oral antiviral drug used in the treatment of hepatitis B infection. It is marketed under the trade name Baraclude (BMS).
Entecavir is a guanine analogue that inhibits all three steps in the viral replication process, and the manufacturer claims that it is more efficacious than previous agents used to treat hepatitis B (lamivudine and adefovir). It was approved by the U.S. Food and Drug Administration (FDA) in March 2005.
|
solid
|
For the treatment of chronic hepatitis B virus infection in adults with evidence of active viral replication and either evidence of persistent elevations in serum aminotransferases (ALT or AST) or histologically active disease.
|
Entecavir is a guanosine nucleoside analogue with selective activity against hepatitis B virus (HBV). It is designed to selectively inhibit the Hepatitis B virus, blocking all three steps in the replication process. Entecavir is more efficient than an older Hepatitis B drug, lamivudine.
|
By competing with the natural substrate deoxyguanosine triphosphate, entecavir functionally inhibits all three activities of the HBV polymerase (reverse transcriptase, rt): (1) base priming, (2) reverse transcription of the negative strand from the pregenomic messenger RNA, and (3) synthesis of the positive strand of HBV DNA. Upon activation by kinases, the drug can be incorporated into the DNA which has the ultimate effect of inhibiting the HBV polymerase activity.
|
Absorption Following oral administration in healthy subjects, entecavir peak plasma concentrations occurred between 0.5 and 1.5 hours. In healthy subjects, the bioavailability of the tablet is 100% relative to the oral solution.
|
Entecavir is not a substrate, inhibitor, or inducer of the cytochrome P450 (CYP450) enzyme system. Entecavir is efficiently phosphorylated to the active triphosphate form.
|
Healthy subjects who received single entecavir doses up to 40 mg or multiple doses up to 20 mg/day for up to 14 days had no increase in or unexpected adverse events. If overdose occurs, the patient must be monitored for evidence of toxicity, and standard supportive treatment applied as necessary.
|
After reaching peak concentration, entecavir plasma concentrations decreased in a bi-exponential manner with a terminal elimination half-life of approximately 128-149 hours. The phosphorylated metabolite has a half-life of 15 hours.
|
Binding of entecavir to human serum proteins in vitro is approximately 13%.
| null | null |
* renal cl=383.2 +/- 101.8 mL/min [Unimpaired renal function]
* renal cl=197.9 +/- 78.1 mL/min [Mild impaired renal function]
* renal cl=135.6 +/- 31.6 mL/min [Moderate impaired renal function]
* renal cl=40.3 +/- 10.1 mL/min [severe impaired renal function]
* apparent oral cl=588.1 +/- 153.7 mL/min [Unimpaired renal function]
* apparent oral cl=309.2 +/- 62.6 mL/min [Mild impaired renal function]
* apparent oral cl=226.3 +/- 60.1 mL/min [Moderate impaired renal function]
* apparent oral cl=100.6 +/- 29.1 mL/min [severe impaired renal function]
* apparent oral cl=50.6 +/- 16.5 mL/min [severe impaired renal function amnaged with Hemodialysis]
* apparent oral cl=35.7 +/- 19.6 mL/min [severe impaired renal function amnaged with CAPD]
|
Organic compounds
|
Nucleosides, nucleotides, and analogues
|
Nucleoside and nucleotide analogues
| null |
[
"approved",
"investigational"
] |
[
"J05AF",
"J05A",
"J05",
"J"
] |
[
"Hepatitis B virus"
] |
[
{
"cost": "28.94",
"description": "Baraclude 0.5 mg tablet",
"unit": "tablet"
},
{
"cost": "28.94",
"description": "Baraclude 1 mg tablet",
"unit": "tablet"
}
] |
[
{
"approved": "2001-05-29",
"country": "Canada",
"expires": "2011-10-11",
"number": "2053339"
},
{
"approved": "1993-04-27",
"country": "United States",
"expires": "2015-08-21",
"number": "5206244"
}
] |
Anhydrous entecavir | Entecavir | Entecavir (anhydrous) | Entecavir anhydrous | Entecavirum
|
[
"Accel-entecavir",
"Apo-entecavir",
"Auro-entecavir",
"Baraclude",
"Baraclude",
"Baraclude",
"Baraclude",
"Baraclude",
"Baraclude",
"Baraclude",
"Baraclude",
"Baraclude",
"Baraclude",
"Baraclude",
"Entecavir",
"Entecavir",
"Entecavir",
"Entecavir",
"Entecavir",
"Entecavir",
"Entecavir",
"Entecavir",
"Entecavir",
"Entecavir",
"Entecavir",
"Entecavir",
"Entecavir",
"Entecavir",
"Entecavir",
"Entecavir",
"Entecavir",
"Entecavir",
"Entecavir",
"Entecavir",
"Entecavir",
"Entecavir",
"Entecavir",
"Entecavir",
"Entecavir",
"Entecavir",
"Entecavir",
"Entecavir",
"Entecavir",
"Entecavir",
"Entecavir",
"Entecavir",
"Entecavir",
"Entecavir",
"Entecavir",
"Entecavir",
"Entecavir",
"Entecavir",
"Entecavir",
"Entecavir",
"Entecavir",
"Entecavir",
"Entecavir",
"Entecavir",
"Entecavir",
"Entecavir",
"Entecavir",
"Entecavir",
"Entecavir",
"Entecavir",
"Entecavir",
"Entecavir",
"Entecavir",
"Entecavir",
"Entecavir Accord",
"Entecavir Accord",
"Entecavir Accord",
"Entecavir Accord",
"Entecavir Accord",
"Entecavir Accord",
"Entecavir Mylan",
"Entecavir Mylan",
"Entecavir Mylan",
"Entecavir Mylan",
"Entecavir Mylan",
"Entecavir Mylan",
"Entecavir Mylan",
"Entecavir Mylan",
"Entecavir Mylan",
"Entecavir Mylan",
"Entecavir Tablets",
"Jamp Entecavir",
"Mint-entecavir",
"PMS-entecavir",
"PMS-entecavir",
"Sandoz Entecavir",
"Truemed Group LLC"
] |
[
"Barcavir",
"Caavirel",
"Entaliv",
"Teviral"
] |
[] |
[] |
[] |
[] |
[] |
DB00443
|
Betamethasone
|
Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties.[A192444] It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders.[A192444] Betamethasone has potent glucocorticoid activity and negligible mineralocorticoid activity.[A192444]
|
solid
|
As a member of the corticosteroid family, betamethasone is indicated for the treatment of several inflammatory conditions. As topical monotherapy, betamethasone is indicated to relieve pruritic and inflammatory symptoms of corticosteroid-responsive-dermatoses.[L11991,L10782,L11997] Betamethasone can be used topically in combination with a vitamin D analog such as calcipotriene to treat plaque psoriasis.[L12000] The corticosteroid is also available as an injectable suspension and can be used to manage a range of inflammatory conditions including endocrine disorders, gastrointestinal disorders, and rheumatic disorders among other conditions.[L11994]
|
Corticosteroids bind to the glucocorticoid receptor inhibiting pro-inflammatory signals, while promoting anti-inflammatory signals.[A187463] Corticosteroids have a wide therapeutic window as patients may require doses that are multiples of what the body naturally produces.[A187463] Patients who require long-term treatment with a corticosteroid should be counselled regarding the risk of hypothalamic-pituitary-adrenal axis suppression and increased susceptibility to infections.[A187463]
|
Glucocorticoids inhibit neutrophil apoptosis and demargination, and inhibit NF-Kappa B and other inflammatory transcription factors.[A187463] They also inhibit phospholipase A2, leading to decreased formation of arachidonic acid derivatives.[A187463] In addition, glucocorticoids promote anti-inflammatory genes like interleukin-10.[A187463]
Corticosteroids like betamethasone can act through nongenomic and genomic pathways.[A31458] The genomic pathway is slower and occurs when glucocorticoids activate glucocorticoid receptors and initiate downstream effects that promote transcription of anti-inflammatory genes including phosphoenolpyruvate carboxykinase (PEPCK), IL-1-receptor antagonist, and tyrosine amino transferase (TAT).[A31458] On the other hand, the nongenomic pathway is able to elicit a quicker response by modulating T-cell, platelet and monocyte activity through the use of existing membrane-bound receptors and second messengers.[A31458]
|
The absorption and potency of any topical corticosteroid including betamethasone depends on the vehicle in which the steroid is delivered. For example, betamethasone dipropionate 0.05% ointment is classified as a highly potent topical steroid, while betamethasone dipropionate 0.05% cream or lotion is considered to be moderately potent.[A192375]
There are several structural modifications that can determine the potency of a topical corticosteroid. For example, corticosteroids containing a halogen at specific carbons, or that contain esters are more potent due to enhanced lipophilicity.[A192378] As such, there is a marked difference between topical products containing betamethasone dipropionate vs. betamethasone valerate. Betamethasone dipropionate contains 2 esters which enhances its potency, while betamethasone valerate has only one ester and is less potent.[A192378]
It should be noted that the use of occlusive dressings with topical steroids significantly increases the absorption, increasing the risk for adverse effects.[L10782]
|
The metabolism of betamethasone yields 6 metabolites.[A192429] The metabolic processes include 6β hydroxylation, 11β-hydroxyl oxidation, and reduction of the C-20 carbonyl group followed by removal of the side chain.[A192429]
|
Chronic high doses of glucocorticoids can lead to the development of cataracts, glaucoma, hypertension, water retention, hyperlipidemia, peptic ulcer, pancreatitis, myopathy, osteoporosis, mood changes, psychosis, dermal atrophy, allergy, acne, hypertrichosis, immune suppression, decreased resistance to infection, moon face, hyperglycemia, hypocalcemia, hypophosphatemia, metabolic acidosis, growth suppression, and secondary adrenal insufficiency.[A188405] Overdose may be treated by adjusting the dose or stopping the corticosteroid as well as initiating symptomatic and supportive treatment.[A188405]
|
In a study that included Indian women of reproductive age, the half-life following a single intramuscular dose of betamethasone phosphate was 10.2 ± 2.5 hours.[A192420]
|
Betamethasone valerate binds to serum albumin and corticosteroid-binding globulin.[A192168,A192363]
|
Corticosteroids are eliminated predominantly in the urine.[A187436]
|
In a study that included Indian women of reproductive age, the volume of distribution following a single intramuscular dose of betamethasone phosphate was 94,584±23,539 mL(s).[A192420]
|
In a study that included Indian women of reproductive age, the CL/F following a single intramuscular dose of betamethasone phosphate was 6,466 ± 805 mL/hour.[A192420]
|
Organic compounds
|
Lipids and lipid-like molecules
|
Steroids and steroid derivatives
|
Hydroxysteroids
|
[
"approved",
"vet_approved"
] |
[
"R01AD",
"R01A",
"R01",
"R",
"D07BC",
"D07B",
"D07",
"D",
"S01BA",
"S01B",
"S01",
"S",
"S01BB",
"S01B",
"S01",
"S",
"S01CB",
"S01C",
"S01",
"S",
"H02AB",
"H02A",
"H02",
"H",
"C05AA",
"C05A",
"C05",
"C",
"S03CA",
"S03C",
"S03",
"S",
"D07XC",
"D07X",
"D07",
"D",
"D07AC",
"D07A",
"D07",
"D",
"A07EA",
"A07E",
"A07",
"A",
"S02BA",
"S02B",
"S02",
"S",
"R03BA",
"R03B",
"R03",
"R",
"S03BA",
"S03B",
"S03",
"S",
"S01CA",
"S01C",
"S01",
"S",
"D07CC",
"D07C",
"D07",
"D"
] |
[
"Humans and other mammals"
] |
[
{
"cost": "2.17",
"description": "Betamethasone dp aug 0.05% crm",
"unit": "g"
},
{
"cost": "2.71",
"description": "Lotrisone cream",
"unit": "g"
},
{
"cost": "2.89",
"description": "Lotrisone 1-0.05% Lotion",
"unit": "ml"
},
{
"cost": "4.19",
"description": "Diprolene af 0.05% cream",
"unit": "g"
},
{
"cost": "5.01",
"description": "Luxiq 0.12% foam",
"unit": "g"
},
{
"cost": "7.68",
"description": "Betamethasone ac-sp 6 mg/ml vial",
"unit": "ml"
},
{
"cost": "8.08",
"description": "Celestone soluspan 6 mg/ml",
"unit": "ml"
},
{
"cost": "9.51",
"description": "Betnesol (5 mg/100Ml) 5 mg/enm Enema",
"unit": "enema"
},
{
"cost": "11.99",
"description": "Betamethasone Valerate 0.1% Cream 15 gm Tube",
"unit": "tube"
},
{
"cost": "11.99",
"description": "Betamethasone Valerate 0.1% Ointment 15 gm Tube",
"unit": "tube"
},
{
"cost": "11.99",
"description": "Beta-Val 0.1% Cream 15 gm Tube",
"unit": "tube"
},
{
"cost": "12.99",
"description": "Betamethasone Dipropionate 0.05% Cream 15 gm Tube",
"unit": "tube"
},
{
"cost": "12.99",
"description": "Betamethasone Valerate 0.1% Cream 45 gm Tube",
"unit": "tube"
},
{
"cost": "12.99",
"description": "Beta-Val 0.1% Cream 45 gm Tube",
"unit": "tube"
},
{
"cost": "13.51",
"description": "Betamethasone Dipropionate 0.05% Ointment 15 gm Tube",
"unit": "tube"
},
{
"cost": "14.99",
"description": "Beta-Val 0.1% Lotion 60ml Bottle",
"unit": "bottle"
},
{
"cost": "15.87",
"description": "Betamethasone Valerate 0.1% Ointment 45 gm Tube",
"unit": "tube"
},
{
"cost": "16.99",
"description": "Betamethasone Valerate 0.1% Lotion 60ml Bottle",
"unit": "bottle"
},
{
"cost": "18.9",
"description": "Betamethasone Dipropionate 0.05% Cream 45 gm Tube",
"unit": "tube"
},
{
"cost": "19.67",
"description": "Betamethasone Dipropionate 0.05% Ointment 45 gm Tube",
"unit": "tube"
},
{
"cost": "39.46",
"description": "Betamethasone Dipropionate Aug 0.05% Gel 15 gm Tube",
"unit": "tube"
},
{
"cost": "39.62",
"description": "Betamethasone Dipropionate Aug 0.05% Cream 15 gm Tube",
"unit": "tube"
},
{
"cost": "40.4",
"description": "Betamethasone Dipropionate 0.05% Lotion 60ml Bottle",
"unit": "bottle"
},
{
"cost": "44.99",
"description": "Maxivate 0.05% Cream 45 gm Tube",
"unit": "tube"
},
{
"cost": "47.89",
"description": "Betamethasone valerate powd",
"unit": "g"
},
{
"cost": "48.96",
"description": "Betamethasone dp powder",
"unit": "g"
},
{
"cost": "49.99",
"description": "Diprolene 0.05% Gel 15 gm Tube",
"unit": "tube"
},
{
"cost": "56.61",
"description": "Betamethasone sod phos powder",
"unit": "g"
},
{
"cost": "58.83",
"description": "Betamethasone Dipropionate Aug 0.05% Ointment 15 gm Tube",
"unit": "tube"
},
{
"cost": "69.38",
"description": "Diprolene 0.05% Ointment 15 gm Tube",
"unit": "tube"
},
{
"cost": "69.38",
"description": "Diprolene AF 0.05% Cream 15 gm Tube",
"unit": "tube"
},
{
"cost": "78.03",
"description": "Betamethasone acetate powd",
"unit": "g"
},
{
"cost": "78.79",
"description": "Diprolene 0.05% Lotion 30ml Bottle",
"unit": "bottle"
},
{
"cost": "88.26",
"description": "Betamethasone Dipropionate Aug 0.05% Gel 50 gm Tube",
"unit": "tube"
},
{
"cost": "88.66",
"description": "Betamethasone Dipropionate Aug 0.05% Cream 50 gm Tube",
"unit": "tube"
},
{
"cost": "100.64",
"description": "Betamethasone Dipropionate Aug 0.05% Lotion 60ml Bottle",
"unit": "bottle"
},
{
"cost": "103.99",
"description": "Diprolene 0.05% Gel 50 gm Tube",
"unit": "tube"
},
{
"cost": "118.42",
"description": "Betamethasone Dipropionate Aug 0.05% Ointment 45 gm Tube",
"unit": "tube"
},
{
"cost": "147.02",
"description": "Diprolene AF 0.05% Cream 50 gm Tube",
"unit": "tube"
},
{
"cost": "147.41",
"description": "Diprolene 0.05% Ointment 50 gm Tube",
"unit": "tube"
},
{
"cost": "148.19",
"description": "Diprolene 0.05% Lotion 60ml Bottle",
"unit": "bottle"
},
{
"cost": "174.7",
"description": "Luxiq 0.12% Foam 50 gm Can",
"unit": "can"
},
{
"cost": "325.17",
"description": "Luxiq 0.12% Foam 100 gm Can",
"unit": "can"
},
{
"cost": "0.06",
"description": "Betaderm Mild 0.05 % Cream",
"unit": "g"
},
{
"cost": "0.06",
"description": "Ratio-Ectosone Mild 0.05 % Cream",
"unit": "g"
},
{
"cost": "0.07",
"description": "Betaderm Mild 0.05 % Ointment",
"unit": "g"
},
{
"cost": "0.09",
"description": "Betaderm Regular 0.1 % Cream",
"unit": "g"
},
{
"cost": "0.09",
"description": "Ratio-Ectosone Scalp 0.1 % Lotion",
"unit": "g"
},
{
"cost": "0.1",
"description": "Betaderm Regular 0.1 % Ointment",
"unit": "g"
},
{
"cost": "0.1",
"description": "Ratio-Ectosone Regular 0.1 % Cream",
"unit": "g"
},
{
"cost": "0.1",
"description": "Valisone Scalp 0.1 % Lotion",
"unit": "g"
},
{
"cost": "0.14",
"description": "Betamethasone va 0.1% cream",
"unit": "g"
},
{
"cost": "0.21",
"description": "Diprosone 0.05 % Cream",
"unit": "g"
},
{
"cost": "0.21",
"description": "Diprosone 0.05 % Lotion",
"unit": "g"
},
{
"cost": "0.21",
"description": "Ratio-Topisone 0.05 % Cream",
"unit": "g"
},
{
"cost": "0.21",
"description": "Ratio-Topisone 0.05 % Lotion",
"unit": "g"
},
{
"cost": "0.23",
"description": "Ratio-Ectosone Mild 0.05 % Lotion",
"unit": "g"
},
{
"cost": "0.23",
"description": "Diprosone 0.05 % Ointment",
"unit": "g"
},
{
"cost": "0.23",
"description": "Ratio-Topisone 0.05 % Ointment",
"unit": "g"
},
{
"cost": "0.3",
"description": "Ratio-Ectosone Regular 0.1 % Lotion",
"unit": "g"
},
{
"cost": "0.32",
"description": "Beta-val 0.1% cream",
"unit": "g"
},
{
"cost": "0.4",
"description": "Prevex B 0.1 % Occlusive Cream",
"unit": "g"
},
{
"cost": "0.49",
"description": "Diprolene Glycol 0.05 % Glycol Lotion",
"unit": "g"
},
{
"cost": "0.49",
"description": "Ratio-Topilene 0.05 % Glycol Lotion",
"unit": "g"
},
{
"cost": "0.54",
"description": "Diprolene Glycol 0.05 % Glycol Cream",
"unit": "g"
},
{
"cost": "0.54",
"description": "Diprolene Glycol 0.05 % Glycol Ointment",
"unit": "g"
},
{
"cost": "0.54",
"description": "Ratio-Topilene 0.05 % Glycol Cream",
"unit": "g"
},
{
"cost": "0.54",
"description": "Ratio-Topilene 0.05 % Glycol Ointment",
"unit": "g"
}
] |
[
{
"approved": "2000-10-03",
"country": "United States",
"expires": "2016-03-01",
"number": "6126920"
},
{
"approved": "2006-07-18",
"country": "United States",
"expires": "2017-05-24",
"number": "7078058"
},
{
"approved": "2004-06-22",
"country": "United States",
"expires": "2020-01-27",
"number": "6753013"
},
{
"approved": "2004-09-07",
"country": "United States",
"expires": "2020-01-27",
"number": "6787529"
},
{
"approved": "2015-09-01",
"country": "United States",
"expires": "2031-12-10",
"number": "9119781"
},
{
"approved": "2016-09-13",
"country": "United States",
"expires": "2030-08-31",
"number": "9439911"
},
{
"approved": "2016-09-06",
"country": "United States",
"expires": "2030-08-31",
"number": "9433630"
},
{
"approved": "2017-05-23",
"country": "United States",
"expires": "2030-08-31",
"number": "9655907"
},
{
"approved": "2016-06-14",
"country": "United States",
"expires": "2030-08-31",
"number": "9364485"
},
{
"approved": "2017-10-03",
"country": "United States",
"expires": "2030-08-31",
"number": "9775851"
},
{
"approved": "2018-01-30",
"country": "United States",
"expires": "2030-08-31",
"number": "9877974"
},
{
"approved": "2018-11-20",
"country": "United States",
"expires": "2031-12-10",
"number": "10130640"
},
{
"approved": "2019-01-15",
"country": "United States",
"expires": "2030-08-31",
"number": "10179137"
},
{
"approved": "2017-02-14",
"country": "United States",
"expires": "2031-06-10",
"number": "9566286"
},
{
"approved": "2020-04-14",
"country": "United States",
"expires": "2031-06-10",
"number": "10617698"
},
{
"approved": "2020-05-26",
"country": "United States",
"expires": "2031-06-10",
"number": "10660908"
},
{
"approved": "2020-06-23",
"country": "United States",
"expires": "2031-06-10",
"number": "10688108"
},
{
"approved": "2020-06-16",
"country": "United States",
"expires": "2031-06-10",
"number": "10682364"
},
{
"approved": "2020-07-21",
"country": "United States",
"expires": "2031-06-10",
"number": "10716799"
},
{
"approved": "2019-04-23",
"country": "United States",
"expires": "2027-09-27",
"number": "10265265"
},
{
"approved": "2019-03-18",
"country": "United States",
"expires": "2039-03-18",
"number": "11638711"
},
{
"approved": "2019-03-18",
"country": "United States",
"expires": "2039-03-18",
"number": "11696919"
}
] |
16β-Methyl-1,4-pregnadiene-9α-fluoro-11β,17α,21-triol-3,20-dione | 9-Fluoro-16β-methylprednisolone | 9α-Fluoro-16β-methylprednisolone | beta-Methasone alcohol | Betadexamethasone | Betametasona | Betamethasone | Bétaméthasone | Betamethasonum | GR | GRL | Nuclear receptor subfamily 3 group C member 1 | 1.14.14.14 | ARO1 | CYAR | CYP19 | CYPXIX | Cytochrome P-450AROM | Cytochrome P450 19A1 | Estrogen synthase | 1.14.14.1 | CYPIIIA5 | Cytochrome P450-PCN3 | 1.14.14.1 | CYPIIIA7 | Cytochrome P450-HFLA | P450HLp2 | 1,4-cineole 2-exo-monooxygenase | 1.14.14.- | Coumarin 7-hydroxylase | CYP2A3 | CYPIIA6 | Cytochrome P450 IIA3 | Cytochrome P450(I) | 1.14.14.1 | CYPIB1 | Hydroperoxy icosatetraenoate dehydratase | 1,4-cineole 2-exo-monooxygenase | 1.14.13.- | CYPIIB6 | Cytochrome P450 IIB1 | 1.14.14.1 | CYPIIC8 | Cytochrome P450 form 1 | Cytochrome P450 IIC2 | Cytochrome P450 MP-12 | Cytochrome P450 MP-20 | S-mephenytoin 4-hydroxylase | (R)-limonene 6-monooxygenase | (S)-limonene 6-monooxygenase | (S)-limonene 7-monooxygenase | 1.14.14.1 | Cholesterol 25-hydroxylase | CYP2C10 | CYPIIC9 | Cytochrome P-450MP | Cytochrome P450 MP-4 | Cytochrome P450 MP-8 | Cytochrome P450 PB-1 | S-mephenytoin 4-hydroxylase | (R)-limonene 6-monooxygenase | (S)-limonene 6-monooxygenase | (S)-limonene 7-monooxygenase | 1.14.14.1 | CYPIIC17 | CYPIIC19 | Cytochrome P450-11A | Cytochrome P450-254C | Fenbendazole monooxygenase (4'-hydroxylating) | Mephenytoin 4-hydroxylase | 1,4-cineole 2-exo-monooxygenase | 1,8-cineole 2-exo-monooxygenase | 1.14.14.1 | Albendazole monooxygenase (sulfoxide-forming) | Albendazole sulfoxidase | Cholesterol 25-hydroxylase | CYP3A3 | CYPIIIA3 | CYPIIIA4 | Cytochrome P450 3A3 | Cytochrome P450 HLp | Cytochrome P450 NF-25 | Cytochrome P450-PCN1 | Nifedipine oxidase | Quinine 3-monooxygenase | CBG | Serpin A6 | Transcortin | ATP-binding cassette sub-family B member 1 | MDR1 | Multidrug resistance protein 1 | P-glycoprotein 1 | PGY1 | Phospholipid transporter ABCB1
|
[
"Amolg A",
"Beben Gel 0.025%",
"Beta 1 Kit",
"Beta 1 Kit",
"Beta Inject Kit",
"Beta Inject Kit",
"Betacort Scalp Lotion 0.1%",
"Betaderm Crm 0.05%",
"Betaderm Crm 0.1%",
"Betaderm Lotion 0.1%",
"Betaderm Ont 0.05%",
"Betaderm Ont 0.1%",
"Betagel - 0.1%",
"Betaject",
"Betaject",
"Betalido Kit",
"Betalido Kit",
"Betalido Kit",
"Betalido Kit",
"Betalido-C",
"Betalido-C",
"Betaloan SUIK",
"Betaloan SUIK",
"Betaloan SUIK",
"Betaloan SUIK",
"Betamethasone",
"Betamethasone Clotrimazole",
"Betamethasone Combo 6mg/mL PF",
"Betamethasone Combo 6mg/mL PF",
"Betamethasone Combo 7mg/mL",
"Betamethasone Combo 7mg/mL",
"Betamethasone Dipropionate",
"Betamethasone Dipropionate",
"Betamethasone Dipropionate",
"Betamethasone Dipropionate",
"Betamethasone Dipropionate",
"Betamethasone Dipropionate",
"Betamethasone Dipropionate",
"Betamethasone Dipropionate",
"Betamethasone Dipropionate",
"Betamethasone Dipropionate",
"Betamethasone Dipropionate",
"Betamethasone Dipropionate",
"Betamethasone Dipropionate",
"Betamethasone Dipropionate",
"Betamethasone Dipropionate",
"Betamethasone Dipropionate",
"Betamethasone Dipropionate",
"Betamethasone Dipropionate",
"Betamethasone Dipropionate",
"Betamethasone Dipropionate",
"Betamethasone Dipropionate",
"Betamethasone Dipropionate",
"Betamethasone Dipropionate",
"Betamethasone Dipropionate",
"Betamethasone Dipropionate",
"Betamethasone Dipropionate",
"Betamethasone Dipropionate",
"Betamethasone Dipropionate",
"Betamethasone Dipropionate",
"Betamethasone Dipropionate",
"Betamethasone Dipropionate",
"Betamethasone Dipropionate",
"Betamethasone dipropionate",
"Betamethasone dipropionate",
"Betamethasone Dipropionate",
"Betamethasone Dipropionate",
"Betamethasone Dipropionate",
"Betamethasone Dipropionate",
"Betamethasone Dipropionate",
"Betamethasone Dipropionate",
"Betamethasone Dipropionate",
"Betamethasone Dipropionate",
"Betamethasone Dipropionate",
"Betamethasone Dipropionate",
"Betamethasone Dipropionate",
"Betamethasone Dipropionate",
"Betamethasone Dipropionate",
"Betamethasone dipropionate",
"Betamethasone Dipropionate",
"Betamethasone dipropionate",
"Betamethasone dipropionate",
"Betamethasone Dipropionate",
"Betamethasone Dipropionate",
"Betamethasone Dipropionate",
"Betamethasone Dipropionate",
"Betamethasone Dipropionate",
"Betamethasone Dipropionate",
"Betamethasone Dipropionate",
"Betamethasone Dipropionate",
"Betamethasone Dipropionate",
"Betamethasone Dipropionate",
"Betamethasone Dipropionate",
"Betamethasone Dipropionate",
"Betamethasone Dipropionate",
"Betamethasone Dipropionate",
"Betamethasone Dipropionate",
"Betamethasone Dipropionate",
"Betamethasone Dipropionate",
"Betamethasone Dipropionate",
"Betamethasone dipropionate",
"Betamethasone Dipropionate",
"Betamethasone Dipropionate",
"Betamethasone Dipropionate",
"Betamethasone Dipropionate",
"Betamethasone Dipropionate",
"Betamethasone Dipropionate",
"Betamethasone Dipropionate",
"Betamethasone Dipropionate",
"Betamethasone Dipropionate",
"Betamethasone dipropionate",
"Betamethasone Dipropionate",
"Betamethasone Dipropionate",
"Betamethasone Dipropionate",
"Betamethasone Dipropionate",
"Betamethasone Dipropionate",
"Betamethasone Dipropionate",
"Betamethasone Dipropionate",
"Betamethasone Dipropionate",
"Betamethasone Dipropionate",
"Betamethasone Dipropionate",
"Betamethasone dipropionate",
"Betamethasone Dipropionate",
"Betamethasone Dipropionate",
"Betamethasone Dipropionate",
"Betamethasone dipropionate",
"Betamethasone Dipropionate",
"Betamethasone Dipropionate",
"Betamethasone Dipropionate",
"Betamethasone Dipropionate",
"Betamethasone Dipropionate",
"Betamethasone Dipropionate 0.05% / Minoxidil 5%",
"Betamethasone Dipropionate 0.05% / Minoxidil 5% / Niacinamide 2% / Pentoxifylline 0.5%",
"Betamethasone Dipropionate 0.05% / Niacinamide 4%",
"Betamethasone Dipropionate Augmented",
"Betamethasone Dipropionate USP, 0.05%",
"Betamethasone Dipropionate USP, 0.05%",
"Betamethasone Diproprionate 0.05% / Minoxidil 7%",
"Betamethasone Sodium Phosphate and Betamethasone Acetate",
"Betamethasone Sodium Phosphate and Betamethasone Acetate",
"Betamethasone Sodium Phosphate and Betamethasone Acetate",
"Betamethasone Sodium Phosphate and Betamethasone Acetate",
"Betamethasone Sodium Phosphate and Betamethasone Acetate",
"Betamethasone Sodium Phosphate and Betamethasone Acetate",
"Betamethasone Sodium Phosphate and Betamethasone Acetate",
"Betamethasone Sodium Phosphate and Betamethasone Acetate",
"Betamethasone Sodium Phosphate and Betamethasone Acetate",
"Betamethasone Sodium Phosphate and Betamethasone Acetate",
"Betamethasone Sodium Phosphate and Betamethasone Acetate",
"Betamethasone Sodium Phosphate and Betamethasone Acetate",
"Betamethasone Sodium Phosphate and Betamethasone Acetate",
"Betamethasone Sodium Phosphate and Betamethasone Acetate",
"Betamethasone SP 24mg/2mL PF",
"Betamethasone Valerate",
"Betamethasone Valerate",
"Betamethasone Valerate",
"Betamethasone Valerate",
"Betamethasone Valerate",
"Betamethasone Valerate",
"Betamethasone Valerate",
"Betamethasone Valerate",
"Betamethasone Valerate",
"Betamethasone Valerate",
"Betamethasone Valerate",
"Betamethasone Valerate",
"Betamethasone Valerate",
"Betamethasone Valerate",
"Betamethasone Valerate",
"Betamethasone Valerate",
"Betamethasone Valerate",
"Betamethasone Valerate",
"Betamethasone Valerate",
"Betamethasone Valerate",
"Betamethasone Valerate",
"Betamethasone Valerate",
"Betamethasone Valerate",
"Betamethasone Valerate",
"Betamethasone Valerate",
"Betamethasone Valerate",
"Betamethasone Valerate",
"Betamethasone Valerate",
"Betamethasone Valerate",
"Betamethasone Valerate",
"Betamethasone Valerate",
"Betamethasone Valerate",
"Betamethasone Valerate",
"Betamethasone Valerate",
"Betamethasone Valerate",
"Betamethasone Valerate",
"Betamethasone Valerate",
"Betamethasone Valerate",
"Betamethasone Valerate",
"Betamethasone Valerate",
"Betamethasone Valerate",
"Betamethasone Valerate",
"Betamethasone Valerate",
"Betamethasone Valerate",
"Betamethasone Valerate",
"Betamethasone Valerate",
"Betamethasone Valerate",
"Betamethasone Valerate",
"Betamethasone Valerate",
"Betamethasone Valerate",
"Betamethasone Valerate",
"Betamethasone Valerate",
"Betamethasone Valerate",
"Betamethasone Valerate",
"Betamethasone Valerate",
"Betamethasone Valerate",
"Betamethasone Valerate",
"Betamethasone Valerate",
"Betamethasone Valerate",
"Betamethasone Valerate",
"Betamethasone Valerate",
"Betamethasone Valerate",
"Betamethasone Valerate",
"Betamethasone Valerate",
"Betamethasone valerate",
"Betamethasone Valerate Lot 0.1% USP",
"Betamycin Ophthalmic/otic Solution",
"Betaprolene Cream 0.05%",
"Betaprolene Ointment 0.05%",
"Betaprone Cream 0.05%",
"Betaprone Lotion 0.05%",
"Betaprone Ointment 0.05%",
"Beteflam",
"Betnesol Eye and Ear Drops",
"Betnesol Eye and Ear Drops 0.1%",
"Betnesol Pellets 0.1mg",
"Betnesol Retention Enema 5mg/100ml",
"Betnesol Retention Enemas",
"Betnesol Tab 0.5mg",
"Betnesol Tablets",
"Betnovate 1/2 Crm 0.05%",
"Betnovate 1/2 Lot 0.05%",
"Betnovate 1/2 Ont 0.05%",
"Betnovate Crm 0.1%",
"Betnovate Lot 0.1%",
"Betnovate Lotion 0.1%",
"Betnovate Ont 0.1%",
"BL-Contrast",
"BL-Contrast",
"Bsp 0820",
"Bsp 0820",
"Calcipotriene and Betamethasone Dipropionate",
"Calcipotriene and Betamethasone Dipropionate",
"Calcipotriene and Betamethasone Dipropionate",
"Calcipotriene and Betamethasone Dipropionate",
"Calcipotriene and Betamethasone Dipropionate",
"Calcipotriene and Betamethasone Dipropionate",
"Calcipotriene and Betamethasone Dipropionate",
"Calcipotriene and Betamethasone Dipropionate",
"Calcipotriene and Betamethasone Dipropionate",
"Calcipotriene and Betamethasone Dipropionate",
"Calcipotriene and Betamethasone Dipropionate",
"Calcipotriene and Betamethasone Dipropionate",
"Calcipotriene and Betamethasone Dipropionate",
"Calcipotriene and Betamethasone Dipropionate",
"Celestoderm V",
"Celestoderm V",
"Celestoderm V Crm 0.1%",
"Celestoderm V Ont 0.1%",
"Celestoderm V/2",
"Celestoderm V/2",
"Celestoderm V/2 Cream .05%",
"Celestoderm V/2 Ointment 0.05%",
"Celestone",
"Celestone Repetabs 1mg",
"Celestone Soluspan",
"Celestone Soluspan",
"Celestone Soluspan",
"Celestone Soluspan",
"Celestone Soluspan",
"Celestone Soluspan",
"Celestone Soluspan",
"Celestone Soluspan",
"Celestone Soluspan",
"Celestone Soluspan",
"Celestone Soluspan",
"Celestone Soluspan",
"Celestone Soluspan",
"Celestone Soluspan",
"Celestone Tab 0.5mg",
"Celestone-G",
"Celestone-G",
"Ciclomazole",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole/Betameth",
"DermacinRx Therazole Pak",
"Diprogen Cream",
"Diprogen Ointment",
"Diprolene",
"Diprolene",
"Diprolene",
"Diprolene",
"Diprolene",
"Diprolene",
"Diprolene",
"Diprolene",
"Diprolene AF",
"Diprolene AF",
"Diprosalic",
"Diprosalic",
"Diprosone",
"Diprosone",
"Diprosone",
"Dom-gentamicin-betamethasone",
"Dovobet Gel",
"Dovobet Ointment",
"Dr. Throwers Beta",
"Dr. Throwers Beta",
"Dr. Throwers Pbc No. 1",
"Enstilar",
"Enstilar",
"Fucibet",
"Garasone Ophthalmic and Otic Solution",
"Garasone Ophthalmic Ointment",
"H-Paxin",
"H-Paxin",
"Lotriderm",
"Lotrisone",
"Lotrisone",
"Lotrisone",
"Luxiq",
"Luxiq",
"Luxiq",
"Luxiq",
"Luxiq",
"Luxiq",
"Marbeta 25 Kit",
"Marbeta 25 Kit",
"Marbeta L Kit",
"Marbeta L Kit",
"Occlucort Film Forming Lot 0.05",
"PMS-clotrimazole-betamethasone",
"PMS-gentamicin-betamethasone",
"Prevex B",
"Pro-lene Glycol Cream - 0.05%",
"Pro-lene Glycol Lotion - 0.05%",
"Pro-lene Glycol Ointment - 0.05%",
"Pro-sone Cream - 0.05%",
"Pro-sone Lotion - 0.05%",
"Pro-sone Ointment - 0.05%",
"Ratio-topisalic",
"ReadySharp Anesthetics plus Betamethasone",
"ReadySharp Anesthetics plus Betamethasone",
"ReadySharp Betamethasone",
"ReadySharp Betamethasone",
"ReadySharp Betamethasone",
"ReadySharp Betamethasone",
"Rhoprolene Glycol Cream 0.5mg/gm",
"Rhoprolene Glycol Lotion 0.5mg/gm",
"Rhoprolene Glycol Ointment 0.5mg/gm",
"Rhoprosone Cream 0.05%",
"Rhoprosone Lotion 0.05%",
"Rhoprosone Oint 0.05%",
"Rivasone Scalp Lot 0.1%",
"Rolene Cream",
"Rolene Lotion",
"Rolene Ointment",
"Rosone Cream",
"Rosone Lotion",
"Rosone Ointment",
"RRB Pak",
"Sandoz Pentasone",
"Sernivo",
"Sernivo",
"Sernivo",
"Taclonex",
"Taclonex",
"Taclonex",
"Taclonex",
"Taclonex",
"Taclonex Scalp",
"Taclonex Scalp",
"Taro Sone Lot 0.05%",
"Taro Sone Ont",
"Taro-calcipotriol / Betamethasone Gel",
"Taro-clotrimazole/betamethasone Dipropionate",
"Taro-sone",
"Teva-betamethasone/ Calcipotriol",
"Teva-ectosone",
"Teva-ectosone",
"Teva-ectosone",
"Teva-ectosone",
"Teva-ectosone",
"Teva-topilene",
"Teva-topilene",
"Teva-topilene",
"Teva-topisone",
"Teva-topisone",
"Teva-topisone",
"Valisone",
"Valisone-G",
"Valisone-G",
"Wynzora"
] |
[
"Bentelan",
"Betnovate",
"Celestamine",
"Diprosone",
"Procort",
"Rinderon"
] |
[
"Betaject",
"Betaject",
"Taclonex Scalp",
"Clotrimazole and Betamethasone Dipropionate",
"Betamethasone Clotrimazole",
"Lotrisone",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Taclonex",
"Celestone Soluspan",
"Celestone Soluspan",
"Beta Inject Kit",
"Beta Inject Kit",
"Betamethasone Combo 7mg/mL",
"Betamethasone Combo 7mg/mL",
"Betamethasone Combo 6mg/mL PF",
"Betamethasone Combo 6mg/mL PF",
"Dr. Throwers Pbc No. 1",
"ReadySharp Anesthetics plus Betamethasone",
"ReadySharp Anesthetics plus Betamethasone",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Celestone Soluspan",
"Celestone Soluspan",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Taclonex Scalp",
"Taclonex",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Lotrisone",
"Taclonex",
"Celestone-G",
"Celestone-G",
"Marbeta 25 Kit",
"Marbeta 25 Kit",
"Betamethasone Sodium Phosphate and Betamethasone Acetate",
"Betamethasone Sodium Phosphate and Betamethasone Acetate",
"ReadySharp Betamethasone",
"ReadySharp Betamethasone",
"Amolg A",
"DermacinRx Therazole Pak",
"Clotrimazole and Betamethasone Dipropionate",
"Betamethasone Dipropionate 0.05% / Minoxidil 5%",
"Clotrimazole and Betamethasone Dipropionate",
"Betamethasone Dipropionate 0.05% / Minoxidil 5% / Niacinamide 2% / Pentoxifylline 0.5%",
"Betamethasone Diproprionate 0.05% / Minoxidil 7%",
"Betamethasone Dipropionate 0.05% / Niacinamide 4%",
"Lotrisone",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Enstilar",
"Taclonex",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Betamethasone Sodium Phosphate and Betamethasone Acetate",
"Betamethasone Sodium Phosphate and Betamethasone Acetate",
"Betamethasone Sodium Phosphate and Betamethasone Acetate",
"Betamethasone Sodium Phosphate and Betamethasone Acetate",
"Calcipotriene and Betamethasone Dipropionate",
"Celestone Soluspan",
"Celestone Soluspan",
"Celestone Soluspan",
"Celestone Soluspan",
"ReadySharp Betamethasone",
"ReadySharp Betamethasone",
"Calcipotriene and Betamethasone Dipropionate",
"Taclonex",
"Betamethasone Sodium Phosphate and Betamethasone Acetate",
"Betamethasone Sodium Phosphate and Betamethasone Acetate",
"Clotrimazole and Betamethasone Dipropionate",
"Calcipotriene and Betamethasone Dipropionate",
"Calcipotriene and Betamethasone Dipropionate",
"H-Paxin",
"H-Paxin",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Betalido Kit",
"Betalido Kit",
"Marbeta L Kit",
"Marbeta L Kit",
"Betaloan SUIK",
"Betaloan SUIK",
"Beta 1 Kit",
"Beta 1 Kit",
"Calcipotriene and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Betamethasone Sodium Phosphate and Betamethasone Acetate",
"Betamethasone Sodium Phosphate and Betamethasone Acetate",
"Calcipotriene and Betamethasone Dipropionate",
"Betamethasone Sodium Phosphate and Betamethasone Acetate",
"Betamethasone Sodium Phosphate and Betamethasone Acetate",
"RRB Pak",
"Clotrimazole and Betamethasone Dipropionate",
"Celestone Soluspan",
"Celestone Soluspan",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Bsp 0820",
"Bsp 0820",
"Calcipotriene and Betamethasone Dipropionate",
"Calcipotriene and Betamethasone Dipropionate",
"Betamethasone Sodium Phosphate and Betamethasone Acetate",
"Betamethasone Sodium Phosphate and Betamethasone Acetate",
"Wynzora",
"Clotrimazole and Betamethasone Dipropionate",
"Ciclomazole",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Calcipotriene and Betamethasone Dipropionate",
"Celestone Soluspan",
"Celestone Soluspan",
"Clotrimazole and Betamethasone Dipropionate",
"Calcipotriene and Betamethasone Dipropionate",
"Calcipotriene and Betamethasone Dipropionate",
"Calcipotriene and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Lotriderm",
"Diprosalic",
"Diprosalic",
"Dovobet Ointment",
"Ratio-topisalic",
"Garasone Ophthalmic Ointment",
"Garasone Ophthalmic and Otic Solution",
"Dovobet Gel",
"Dom-gentamicin-betamethasone",
"Valisone-G",
"Diprogen Ointment",
"Diprogen Cream",
"Celestone Soluspan",
"Celestone Soluspan",
"Enstilar",
"PMS-clotrimazole-betamethasone",
"Sandoz Pentasone",
"Valisone-G",
"PMS-gentamicin-betamethasone",
"Betamycin Ophthalmic/otic Solution",
"Fucibet",
"Teva-betamethasone/ Calcipotriol",
"Taro-clotrimazole/betamethasone Dipropionate",
"Taro-calcipotriol / Betamethasone Gel",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Betalido Kit",
"Betalido Kit",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Betaloan SUIK",
"Betaloan SUIK",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole/Betameth",
"Calcipotriene and Betamethasone Dipropionate",
"BL-Contrast",
"BL-Contrast",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Betalido-C",
"Betalido-C",
"Clotrimazole and Betamethasone Dipropionate",
"Calcipotriene and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate",
"Clotrimazole and Betamethasone Dipropionate"
] |
[
"P04150"
] |
[
"P11511",
"P20815",
"P24462",
"P11509",
"Q16678",
"P20813",
"P10632",
"P11712",
"P33261",
"P08684"
] |
[
"P02768",
"P08185"
] |
[
"P08183"
] |
DB00444
|
Teniposide
|
Teniposide is a semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells from entering into the mitotic phase of the cell cycle, and lead to cell death. Teniposide acts primarily in the G2 and S phases of the cycle.
|
solid
|
Teniposide is used for the treatment of refractory acute lymphoblastic leukaemia
|
Teniposide is a phase-specific cytotoxic drug, acting in the late S or early G 2 phase of the cell cycle. Teniposide prevents cell mitosis by causing single and double stranded DNA breaks as well as cross linking between protein and DNA.
|
The mechanism of action appears to be related to the inhibition of type II topoisomerase activity since teniposide does not intercalate into DNA or bind strongly to DNA. Teniposide binds to and inhibits DNA topoisomerase II. The cytotoxic effects of teniposide are related to the relative number of double-stranded DNA breaks produced in cells, which are a reflection of the stabilization of a topoisomerase II-DNA intermediate.
| null | null | null |
5 hours
| null |
From 4% to 12% of a dose is excreted in urine as parent drug. Fecal excretion of radioactivity within 72 hours after dosing accounted for 0% to 10% of the dose.
| null |
* 10.3 mL/min/m2
|
Organic compounds
|
Lignans, neolignans and related compounds
|
Lignan lactones
|
Podophyllotoxins
|
[
"approved"
] |
[
"L01CB",
"L01C",
"L01",
"L"
] |
[
"Humans and other mammals"
] |
[
{
"cost": "75.31",
"description": "Vumon 10 mg/ml ampul",
"unit": "ml"
}
] |
[] |
4'-demethylepipodophyllotoxin 9-(4,6-O-(R)-2-thenylidene-beta-D-glucopyranoside) | Epidophyllotoxin | Teniposid | Teniposide | Téniposide | Teniposido | Teniposidum | 5.6.2.2 | DNA topoisomerase II, alpha isozyme | TOP2 | 5.6.2.2 | DNA topoisomerase II, beta isozyme | 1.14.14.1 | CYPIIIA5 | Cytochrome P450-PCN3 | (R)-limonene 6-monooxygenase | (S)-limonene 6-monooxygenase | (S)-limonene 7-monooxygenase | 1.14.14.1 | CYPIIC17 | CYPIIC19 | Cytochrome P450-11A | Cytochrome P450-254C | Fenbendazole monooxygenase (4'-hydroxylating) | Mephenytoin 4-hydroxylase | (R)-limonene 6-monooxygenase | (S)-limonene 6-monooxygenase | (S)-limonene 7-monooxygenase | 1.14.14.1 | Cholesterol 25-hydroxylase | CYP2C10 | CYPIIC9 | Cytochrome P-450MP | Cytochrome P450 MP-4 | Cytochrome P450 MP-8 | Cytochrome P450 PB-1 | S-mephenytoin 4-hydroxylase | 1,4-cineole 2-exo-monooxygenase | 1,8-cineole 2-exo-monooxygenase | 1.14.14.1 | Albendazole monooxygenase (sulfoxide-forming) | Albendazole sulfoxidase | Cholesterol 25-hydroxylase | CYP3A3 | CYPIIIA3 | CYPIIIA4 | Cytochrome P450 3A3 | Cytochrome P450 HLp | Cytochrome P450 NF-25 | Cytochrome P450-PCN1 | Nifedipine oxidase | Quinine 3-monooxygenase | 7.6.2.- | 7.6.2.3 | Anthracycline resistance-associated protein | ARA | MOAT-E | MRP6 | Multi-specific organic anion transporter E | Multidrug resistance-associated protein 6 | 7.6.2.2 | ABCP | ATP-binding cassette sub-family G member 2 | BCRP | BCRP1 | Breast cancer resistance protein | CDw338 | Mitoxantrone resistance-associated protein | MXR | Placenta-specific ATP-binding cassette transporter | Urate exporter
|
[
"Teniposide",
"Vumon",
"Vumon"
] |
[
"Bang Lai"
] |
[] |
[
"P11388",
"Q02880"
] |
[
"P20815",
"P33261",
"P11712",
"P08684"
] |
[] |
[
"O95255",
"Q9UNQ0"
] |
DB00445
|
Epirubicin
|
An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA.
|
solid
|
For use as a component of adjuvant therapy in patients with evidence of axillary node tumor involvement following resection of primary breast cancer.
|
Epirubicin is an antineoplastic in the anthracycline class. General properties of drugs in this class include: interaction with DNA in a variety of different ways including intercalation (squeezing between the base pairs), DNA strand breakage and inhibition with the enzyme topoisomerase II. Most of these compounds have been isolated from natural sources and antibiotics. However, they lack the specificity of the antimicrobial antibiotics and thus produce significant toxicity. The anthracyclines are among the most important antitumor drugs available. Doxorubicin is widely used for the treatment of several solid tumors while daunorubicin and idarubicin are used exclusively for the treatment of leukemia. Epirubicin may also inhibit polymerase activity, affect regulation of gene expression, and produce free radical damage to DNA. Epirubicin possesses an antitumor effect against a wide spectrum of tumors, either grafted or spontaneous. The anthracyclines are cell cycle-nonspecific.
|
Epirubicin has antimitotic and cytotoxic activity. It inhibits nucleic acid (DNA and RNA) and protein synthesis through a number of proposed mechanisms of action: Epirubicin forms complexes with DNA by intercalation between base pairs, and it inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the ligation-religation reaction that topoisomerase II catalyzes. It also interferes with DNA replication and transcription by inhibiting DNA helicase activity.
|
100%
|
Extensively and rapidly metabolized in the liver. Epirubicin is also metabolized by other organs and cells, including red blood cells. The four main metabolic routes are: (1) reduction of the C-13 keto-group with the formation of the 13(S)-dihydro derivative, epirubicinol; (2) conjugation of both the unchanged drug and epirubicinol with glucuronic acid; (3) loss of the amino sugar moiety through a hydrolytic process with the formation of the doxorubicin and doxorubicinol aglycones; and (4) loss of the amino sugar moiety through a redox process with the formation of the 7-deoxy-doxorubicin aglycone and 7-deoxy-doxorubicinol aglycone. Epirubicinol exhibits in vitro cytoxic activity (~10% that of epirubicin), but it is unlikely to reach sufficient concentrations in vivo to produce cytotoxic effects.
|
bone marrow aplasia, grade 4 mucositis, and gastrointestinal bleeding
|
Half-lives for the alpha, beta, and gamma phases of about 3 minutes, 2.5 hours and 33 hours, respectively
|
77%
|
Epirubicin and its major metabolites are eliminated through biliary excretion and, to a lesser extent, by urinary excretion.
|
* 21 ± 2 L/kg [60 mg/m2 Dose]
* 27 ± 11 L/kg [75 mg/m2 Dose]
* 23 ± 7 L/kg [120 mg/m2 Dose]
* 21 ± 7 L/kg [150 mg/m2 Dose]
|
* 65 +/- 8 L/hour [Patients1 with Solid Tumors Receiving Intravenous Epirubicin 60 mg/m2]
* 83 +/- 14 L/hour [Patients1 with Solid Tumors Receiving Intravenous Epirubicin 75 mg/m2]
* 65 +/- 13 L/hour [Patients1 with Solid Tumors Receiving Intravenous Epirubicin 120 mg/m2]
* 69 +/- 13 L/hour [Patients1 with Solid Tumors Receiving Intravenous Epirubicin 150 mg/m2]
|
Organic compounds
|
Phenylpropanoids and polyketides
|
Anthracyclines
| null |
[
"approved"
] |
[
"L01DB",
"L01D",
"L01",
"L"
] |
[
"Humans and other mammals"
] |
[
{
"cost": "5.38",
"description": "Ellence 2 mg/ml vial",
"unit": "ml"
},
{
"cost": "69.54",
"description": "Epirubicin hcl 50 mg vial",
"unit": "vial"
},
{
"cost": "2845.85",
"description": "Epirubicin hcl 200 mg vial",
"unit": "vial"
}
] |
[] |
(1S,3S)-3-GLYCOLOYL-1,2,3,4,6,11-HEXAHYDRO-3,5,12-TRIHYDROXY-10-METHOXY-6,11-DIOXO-1-NAPHTHACENYL 3-AMINO-2,3,6-TRIDEOXY-.ALPHA.-L-ARABINO-HEXOPYRANOSIDE | 4'-EPI-ADRIAMYCIN | 4'-Epiadriamycin | 5,12-NAPHTHACENEDIONE, 10-((3-AMINO-2,3,6-TRIDEOXY-.ALPHA.-L-ARABINO-HEXOPYRANOSYL)OXY)-7,8,9,10-TETRAHYDRO-6,8,11-TRIHYDROXY-8-(HYDROXYACETYL)-1-METHOXY-, (8S-CIS)- | Epiadriamycin | Epirubicin | epirubicin-conjugated polymer micelles | Epirubicina | Epirubicine | Epirubicinum | Pidorubicina | Pidorubicine | Pidorubicinum | 5.6.2.2 | DNA topoisomerase II, beta isozyme | 5.6.2.2 | DNA topoisomerase II, alpha isozyme | TOP2 | 2.4.1.17 | 3,4-catechol estrogen-specific UDPGT | UDP-glucuronosyltransferase 2B9 | UDPGT 2B7 | UDPGT 2B9 | UDPGTh-2 | UGT2B7 | UGTB2B9 | CPLA2 | Phospholipase A2 group IVA | PLA2G4 | 7.6.2.2 | ATP-binding cassette sub-family C member 1 | Glutathione-S-conjugate-translocating ATPase ABCC1 | Leukotriene C(4) transporter | LTC4 transporter | MRP | MRP1
|
[
"Ellence",
"Ellence",
"Epirubicin for Injection",
"Epirubicin Hydrochloride",
"Epirubicin Hydrochloride",
"Epirubicin Hydrochloride",
"Epirubicin Hydrochloride",
"Epirubicin Hydrochloride",
"Epirubicin hydrochloride",
"Epirubicin hydrochloride",
"Epirubicin Hydrochloride",
"Epirubicin Hydrochloride",
"Epirubicin Hydrochloride",
"Epirubicin Hydrochloride",
"Epirubicin Hydrochloride",
"Epirubicin Hydrochloride",
"Epirubicin Hydrochloride",
"Epirubicin Hydrochloride",
"Epirubicin Hydrochloride",
"Epirubicin Hydrochloride",
"Epirubicin Hydrochloride",
"Epirubicin Hydrochloride",
"Epirubicin Hydrochloride",
"Epirubicin Hydrochloride",
"Epirubicin Hydrochloride",
"Epirubicin Hydrochloride",
"Epirubicin Hydrochloride",
"Epirubicin Hydrochloride for Injection",
"Epirubicin Hydrochloride Injection",
"Epirubicin Hydrochloride Injection",
"Epirubicin Hydrochloride Injection",
"Epirubicin Hydrochloride Injection",
"Epirubicin Hydrochloride Injection",
"Epirubicin Hydrochloride Injection",
"Epirubicin Hydrochloride Injection",
"Epirubicin Hydrochloride Injection",
"Pharmorubicin PFS",
"Pharmorubicin Rdf",
"Pharmorubicin Rdf",
"Pharmorubicin Rdf Inj 50mg/vial",
"PMS-epirubicin",
"Truemed Group LLC"
] |
[
"Epirubicin Ebewe",
"Pharmorubicin"
] |
[] |
[
"Q02880",
"P11388"
] |
[
"P16662",
"P47712"
] |
[] |
[
"P33527"
] |
DB00447
|
Loracarbef
|
Loracarbef is a carbacephem antibiotic sometimes grouped together with the second-generation cephalosporin antibiotics. It is marketed under the trade name Lorabid.
|
solid
|
Used to treat upper respiratory tract bacterial infections, chronic bronchitis, pneumonia, sinusitis, pharyntitis and tonsillitis, skin absceses, urinary tract infections and pyelonephritis caused by <i>E. coli</i>, <i>S. pyogenes</i>, <i>S. aureus</i>, <i>S. saprphyticus</i>, <i>S. penumoniae</i>, <i>H. influenzae</i> and <i>M. catarrhalis</i>.
|
Loracarbef is considered a second generation cephalosporin antibiotic. The advantages of cephalosporin antibiotics include a broad range of activity, a safe record in children with almost no dose-related toxicity, and the lack of need to monitor levels. Adverse reactions are rare and consist primarily of hypersensitivity reactions with urticaria, nonspecific rash, and pruritus. Loracarbef can be used to treat a large number of bacterial infections caused by gram-negative and gram-positive bacteria, including upper respiratory tract bacterial infections, chronic bronchitis, pneumonia, sinusitis, pharyntitis and tonsillitis, skin absceses, urinary tract infections and pyelonephritis caused by <i>E. coli</i>, <i>S. pyogenes</i>, <i>S. aureus</i>, <i>S. saprphyticus</i>, <i>S. penumoniae</i>, <i>H. influenzae</i> and <i>M. catarrhalis</i>.
|
Loracarbef is an oral, synthetic beta-lactam antibiotic of the carbacephem class. Chemically, carbacephems differ from cephalosporin-class antibiotics in the dihydrothiazine ring where a methylene group has been substituted for a sulfur atom. Loracarbef has a spectrum of activity similar to that of the second generation cephalosporins. It is structurally identical to cefaclor except for a sulfur atom that has been replaced by a methylene group. This change gives greater chemical stability in solution and allows storage at room temperature. Loracarbef, like all b-lactams and cephalosporins, inhibits penicillin binding proteins, enzymes that create the cross-linkage of the peptidoglycan polymer. This binding leads to interference with the formation and remodeling of the cell wall structure.
|
Well absorbed with approximately 90% absorbed from the gastrointestinal tract after oral ingestion.
|
There is no evidence of metabolism in humans.
|
Adverse effects include diarrhea, nausea, stomach upset, vomiting, headache, dizziness, rash, bone marrow depression.
|
1 hour. In subjects with moderate impairment of renal function the plasma half-life was prolonged to approximately 5.6 hours.
|
25%
| null | null | null |
Organic compounds
|
Organoheterocyclic compounds
|
Lactams
|
Beta lactams
|
[
"approved",
"investigational",
"withdrawn"
] |
[
"J01DC",
"J01D",
"J01",
"J"
] |
[
"Various gram-negative and gram-positive eubacteria",
"Staphylococcus aureus",
"Streptococcus pneumoniae",
"Streptococcus pyogenes",
"Haemophilus influenzae",
"Escherichia coli"
] |
[] |
[
{
"approved": "2001-06-05",
"country": "Canada",
"expires": "2011-01-18",
"number": "2034592"
},
{
"approved": "1995-03-28",
"country": "Canada",
"expires": "2012-03-28",
"number": "1334970"
}
] |
Anhydrous loracarbef | Loracarbef | Loracarbef anhydrous | Loracarbef, anhydrous | Loracarbefum | Putative D-alanyl-D-alanine carboxypeptidase | PBP1 | Intestinal H(+)/peptide cotransporter | Oligopeptide transporter, small intestine isoform | PEPT1 | Peptide transporter 1 | Kidney H(+)/peptide cotransporter | Oligopeptide transporter, kidney isoform | PEPT2 | Peptide transporter 2
|
[
"Lorabid",
"Lorabid",
"Lorabid",
"Lorabid",
"Lorabid"
] |
[
"Lorafem",
"Lorbef"
] |
[] |
[] |
[] |
[] |
[
"P46059",
"Q16348"
] |
DB00448
|
Lansoprazole
|
Lansoprazole marketed under the brand Prevacid, is a proton pump inhibitor (PPI) and is structurally classified as a substituted benzimidazole.[A177065] It reduces gastric acid secretion by targeting gastric H,K-ATPase pumps and is thus effective at promoting healing in ulcerative diseases, and treating gastroesophageal reflux disease (GERD) along with other pathologies caused by excessive acid secretion.[A177053]
|
solid
|
Lansoprazole is used to reduce gastric acid secretion and is approved for short term treatment of active gastric ulcers, active duodenal ulcers, erosive reflux oesophagitis, symptomatic gastroesophageal reflux disease, and non-steroidal anti-inflammatory drug (NSAID) induced gastric and duodenal ulcers. [A4892][A177065][FDA Label] It may be used in the maintenance and healing of several gastric conditions including duodenal ulcers, NSAID related gastric ulcers, and erosive esophagitis.[FDA Label] Lansoprazole prevents recurrence of gastric ulcers in patients who have a documented history of gastric ulcers who also use NSAIDs chronically. [FDA Label] Predictably, it is also useful in the management of hypersecretory conditions including Zollinger-Ellison syndrome. [FDA Label] Lansoprazole is effective at eradicating H. pylori when used in conjunction with amoxicillin and clarithromycin (triple therapy) or with amoxicillin alone (dual therapy). [FDA Label]
|
Lansoprazole decreases gastric acid secretion by targeting H+,K+-ATPase, which is the enzyme that catalyzes the final step in the acid secretion pathway in parietal cells. [A177080] Conveniently, lansoprazole administered any time of day is able to inhibit both daytime and nocturnal acid secretion.[A177080] The result is that lansoprazole is effective at healing duodenal ulcers, reduces ulcer-related pain, and offers relief from symptoms of heartburn [A177080] Lansoprazole also reduces pepsin secretion, making it a useful treatment option for hypersecretory conditions such as Zollinger-Ellison syndrome.[A177089][A177080]
|
As a PPI, lansoprazole is a prodrug and requires protonation via an acidic environment to become activated. [A174244] Once protonated, lansoprazole is able to react with cysteine residues, specifically Cys813 and Cys321, on parietal H+,K+-ATPase resulting in stable disulfides.[A174244][A177077] PPI's in general are able to provide prolonged inhibition of acid secretion due to their ability to bind covalently to their targets.[A174244]
|
The oral bioavailability of lansoprazole is reported to be 80-90%[A177053] and the peak plasma concentration(Cmax) is achieved about 1.7 hours after oral dosing.[FDA Label] Food reduces the absorption of lansoprazole (both Cmax and AUC are reduced by 50-70%); therefore, patients should be instructed to take lansoprazole before meals.[FDA Label]
|
Lansoprazole is predominantly metabolized in the liver by CYP3A4 and CYP2C19. [A174244] The resulting major metabolites are 5-hydroxy lansoprazole and the sulfone derivative of lansoprazole. [A174244][FDA Label]
|
The most commonly reported adverse events occurring more frequently in lansoprazole treated patients compared to placebo include abdominal pain, constipation, diarrhea, and nausea.[FDA Label] There is a case report of toxic epidermal necrolysis (TEN), which is a rare but very serious cutaneous reaction, caused by lansoprazole.[A177190] The previously healthy patient presented with symptoms of TEN 15 days after starting lansoprazole to manage peptic disease.[A177190] Although the use of PPI's is rarely associated with TEN, causation should be considered if a patient presents with TEN shortly after newly commencing a PPI.[A177190]
In a single case report, a patient ingested 600 mg of lansoprazole and did not experience any adverse effects or symptoms of overdose.[FDA Label] Overall, lansoprazole is well tolerated with relatively few adverse effects.
Lansoprazole is classified as Pregnancy Category B.[FDA Label] Although there are animal studies that suggest lansoprazole does not cause harm to the fetus, there is still a paucity of human data. Hence, lansoprazole should only be administered to pregnant women if other options with more safety data have been exhausted.
It is unknown if lansoprazole is excreted in human breast milk.[FDA Label] It is worth mentioning that lansoprazole has been used safely in infants, and is therefore likely safe to use during breastfeeding.[L6340]
|
One source reports the half life of lansoprazole to be 0.9 - 1.6 hours[A177053], while another source cites 0.9 - 2.1 hours[A174244]. The general consensus is that lansoprazole has a short half life and is approximately 2 hours or less. [FDA Label] These numbers may be misleading since it suggests that lansoprazole has a short duration of action when in practice, lansoprazole can effectively inhibit acid secretion for ~24 hours due to it's mechanism of action. [FDA Label]
|
97% of lansoprazole is plasma protein bound. [FDA Label]
|
A reported 14-23% of a lansoprazole is eliminated in the urine with this percentage range including both conjugated and unconjugated hydroxylated metabolites. [A177080]
|
The apparent volume of distribution of lansoprazole is 0.4 L/kg. [A174244]
|
The reported clearance of lansoprazole is 400-650 mL/min. [A174244]
|
Organic compounds
|
Organoheterocyclic compounds
|
Benzimidazoles
|
Sulfinylbenzimidazoles
|
[
"approved",
"investigational"
] |
[
"A02BC",
"A02B",
"A02",
"A",
"A02BD",
"A02B",
"A02",
"A",
"A02BD",
"A02B",
"A02",
"A",
"A02BD",
"A02B",
"A02",
"A",
"A02BD",
"A02B",
"A02",
"A",
"A02BD",
"A02B",
"A02",
"A",
"A02BC",
"A02B",
"A02",
"A"
] |
[
"Humans and other mammals"
] |
[
{
"cost": "1.17",
"description": "Apo-Lansoprazole 15 mg Delayed Release Capsule",
"unit": "capsule"
},
{
"cost": "1.17",
"description": "Apo-Lansoprazole 30 mg Delayed Release Capsule",
"unit": "capsule"
},
{
"cost": "1.17",
"description": "Novo-Lansoprazole 15 mg Delayed Release Capsule",
"unit": "capsule"
},
{
"cost": "1.17",
"description": "Novo-Lansoprazole 30 mg Delayed Release Capsule",
"unit": "capsule"
},
{
"cost": "4.32",
"description": "Prevacid 15 mg Delayed Release Capsule",
"unit": "capsule"
},
{
"cost": "4.45",
"description": "Prevacid 30 mg Delayed Release Capsule",
"unit": "capsule"
},
{
"cost": "5.67",
"description": "Lansoprazole dr 15 mg capsule",
"unit": "capsule"
},
{
"cost": "5.67",
"description": "Lansoprazole dr 30 mg capsule",
"unit": "capsule"
},
{
"cost": "5.73",
"description": "Prevacid 15 mg solutab",
"unit": "tablet"
},
{
"cost": "5.73",
"description": "Prevacid 30 mg solutab",
"unit": "tablet"
},
{
"cost": "5.9",
"description": "Lansoprazole 15 mg Delayed Release Capsule",
"unit": "capsule"
},
{
"cost": "5.9",
"description": "Lansoprazole 30 mg Delayed Release Capsule",
"unit": "capsule"
},
{
"cost": "5.91",
"description": "Prevacid dr 30 mg capsule",
"unit": "capsule"
},
{
"cost": "6.0",
"description": "Prevacid 15 mg capsule dr",
"unit": "capsule"
},
{
"cost": "6.0",
"description": "Prevacid 30 mg capsule dr",
"unit": "capsule"
},
{
"cost": "6.21",
"description": "Prevacid SoluTab 30 mg Dispersible Tablet",
"unit": "dispersible tablet"
},
{
"cost": "6.25",
"description": "Prevacid dr 15 mg capsule",
"unit": "capsule"
},
{
"cost": "27.31",
"description": "Prevacid iv 30 mg vial",
"unit": "vial"
},
{
"cost": "27.54",
"description": "Lansoprazole 100% powder",
"unit": "g"
},
{
"cost": "28.22",
"description": "Prevpac patient pack",
"unit": "each"
},
{
"cost": "32.02",
"description": "Prevpac Miscellaneous",
"unit": "ea"
},
{
"cost": "175.8",
"description": "Prevacid NapraPAC 84 15-500 mg Kit Box",
"unit": "box"
},
{
"cost": "620.65",
"description": "Prevacid SoluTab 100 15 mg Dispersible Tablet Box",
"unit": "box"
},
{
"cost": "0.86",
"description": "Prevacid 24hr dr 15 mg capsule",
"unit": "capsule"
}
] |
[
{
"approved": "1986-12-09",
"country": "United States",
"expires": "2009-11-10",
"number": "4628098"
},
{
"approved": "2008-12-23",
"country": "Canada",
"expires": "2021-08-17",
"number": "2419067"
},
{
"approved": "1994-02-15",
"country": "Canada",
"expires": "2011-02-15",
"number": "1327010"
},
{
"approved": "2008-07-15",
"country": "United States",
"expires": "2018-11-26",
"number": "7399485"
},
{
"approved": "2001-12-11",
"country": "United States",
"expires": "2019-11-17",
"number": "6328994"
},
{
"approved": "2011-01-25",
"country": "United States",
"expires": "2019-11-17",
"number": "7875292"
},
{
"approved": "2008-10-07",
"country": "United States",
"expires": "2019-11-17",
"number": "7431942"
},
{
"approved": "2008-07-08",
"country": "United States",
"expires": "2022-02-17",
"number": "7396841"
},
{
"approved": "2018-02-27",
"country": "United States",
"expires": "2019-11-17",
"number": "9901546"
},
{
"approved": "2021-08-03",
"country": "United States",
"expires": "2036-04-21",
"number": "11077055"
},
{
"approved": "2016-04-21",
"country": "United States",
"expires": "2036-04-21",
"number": "11986554"
}
] |
Lansoprazol | Lansoprazole | Lansoprazolum | 7.2.2.19 | Gastric H(+)/K(+) ATPase subunit alpha | Proton pump | MAPTL | MTBT1 | Neurofibrillary tangle protein | Paired helical filament-tau | PHF-tau | TAU | 1.14.14.1 | CYPIA1 | Cytochrome P450 form 6 | Cytochrome P450-C | Cytochrome P450-P1 | Hydroperoxy icosatetraenoate dehydratase | 1.14.14.1 | CYPIB1 | Hydroperoxy icosatetraenoate dehydratase | 1.14.14.1 | CYPIIC8 | Cytochrome P450 form 1 | Cytochrome P450 IIC2 | Cytochrome P450 MP-12 | Cytochrome P450 MP-20 | S-mephenytoin 4-hydroxylase | (R)-limonene 6-monooxygenase | (S)-limonene 6-monooxygenase | (S)-limonene 7-monooxygenase | 1.14.14.1 | Cholesterol 25-hydroxylase | CYP2C10 | CYPIIC9 | Cytochrome P-450MP | Cytochrome P450 MP-4 | Cytochrome P450 MP-8 | Cytochrome P450 PB-1 | S-mephenytoin 4-hydroxylase | 1.14.14.1 | CYPIIC18 | Cytochrome P450-6b/29c | 1.14.14.- | Cholesterol 25-hydroxylase | CYP2DL1 | CYPIID6 | Cytochrome P450-DB1 | Debrisoquine 4-hydroxylase | 1,4-cineole 2-exo-monooxygenase | 1,8-cineole 2-exo-monooxygenase | 1.14.14.1 | Albendazole monooxygenase (sulfoxide-forming) | Albendazole sulfoxidase | Cholesterol 25-hydroxylase | CYP3A3 | CYPIIIA3 | CYPIIIA4 | Cytochrome P450 3A3 | Cytochrome P450 HLp | Cytochrome P450 NF-25 | Cytochrome P450-PCN1 | Nifedipine oxidase | Quinine 3-monooxygenase | (R)-limonene 6-monooxygenase | (S)-limonene 6-monooxygenase | (S)-limonene 7-monooxygenase | 1.14.14.1 | CYPIIC17 | CYPIIC19 | Cytochrome P450-11A | Cytochrome P450-254C | Fenbendazole monooxygenase (4'-hydroxylating) | Mephenytoin 4-hydroxylase | 7.6.2.2 | ABCP | ATP-binding cassette sub-family G member 2 | BCRP | BCRP1 | Breast cancer resistance protein | CDw338 | Mitoxantrone resistance-associated protein | MXR | Placenta-specific ATP-binding cassette transporter | Urate exporter | ATP-binding cassette sub-family B member 1 | MDR1 | Multidrug resistance protein 1 | P-glycoprotein 1 | PGY1 | Phospholipid transporter ABCB1 | hOAT3 | OAT3 | Organic anion/dicarboxylate exchanger | Solute carrier family 22 member 8 | hOCT1 | OCT1 | Organic cation transporter 1 | hOCT2 | OCT2 | Organic cation transporter 2 | EMT | EMTH | Extraneuronal monoamine transporter | OCT3 | Organic cation transporter 3
|
[
"Aa-lansoprazole-amoxicillin-clarithromycin",
"Apo-lansoprazole",
"Apo-lansoprazole",
"Basic Care Lansoprazole",
"Basic Care Lansoprazole",
"Basic Care Lansoprazole",
"Basic Care Lansoprazole",
"Basic Care Lansoprazole",
"Berkley and Jensen Lansoprazole",
"CareOne Acid Reducer",
"Careone Acid Reducer",
"CareOne Lansoprazole",
"Caring Mill Lansoprazole",
"Dg Health Lansoprazole",
"Dg Health Lansoprazole",
"Dom-lansoprazole",
"Dom-lansoprazole",
"Equaline Lansoprazole",
"Equaline Lansoprazole",
"Equate Lansoprazole",
"Equate Lansoprazole",
"Equate Lansoprazole Delayed Release",
"Exchange Select Lansoprazole",
"FIRST Lansoprazole Rx",
"Foster and Thrive Acid Reducer",
"Good Neighbor Pharmacy Lansoprazole",
"Good Neighbor Pharmacy Lansoprazole",
"Good Sense Lansoprazole",
"Good Sense lansoprazole",
"Good Sense Lansoprazole",
"Harris Teeter Acid Reducer",
"Health Mart Lansoprazole",
"Health Mart lansoprazole",
"Healthy Accents Lansoprazole",
"Heartburn Relief 24 hour",
"Hp-pac",
"Kirkland Signature Lansoprazole",
"Kirkland Signature Lansoprazole Delayed Release",
"Lansoprazole",
"Lansoprazole",
"Lansoprazole",
"Lansoprazole",
"Lansoprazole",
"Lansoprazole",
"Lansoprazole",
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"Lansoprazole",
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"Lansoprazole",
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"Lansoprazole",
"Lansoprazole",
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"Lansoprazole",
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"Lansoprazole",
"Lansoprazole",
"Lansoprazole",
"Lansoprazole",
"Lansoprazole",
"Lansoprazole",
"Lansoprazole",
"Lansoprazole",
"Lansoprazole",
"Lansoprazole",
"Lansoprazole",
"Lansoprazole",
"Lansoprazole",
"Lansoprazole",
"Lansoprazole",
"Lansoprazole",
"Lansoprazole",
"Lansoprazole",
"Lansoprazole",
"Lansoprazole",
"Lansoprazole 24 HR",
"Lansoprazole Delayed-release Orally Disintegrating",
"Lansoprazole Delayed-release Orally Disintegrating",
"Lansoprazole DR",
"Lansoprazole DR",
"Lansoprazole DR",
"Lansoprazole Heartburn Relief 24 Hour",
"Lansoprazole-15",
"Lansoprazole-30",
"Lansoprazole, Amoxicillin and Clarithromycin",
"Lansoprazole, Amoxicillin and Clarithromycin",
"Lansoprazole, Amoxicillin, and Clarithromycin",
"Lansoprazole, Amoxicillin, Clarithromycin",
"Leader Lansoprazole",
"Leader lansoprazole",
"M-lansoprazole",
"M-lansoprazole",
"Members Mark Lansoprazole",
"Members Mark Lansoprazole",
"Mylan-lansoprazole",
"Mylan-lansoprazole",
"Mylan-lansoprazole Fdt",
"Mylan-lansoprazole Fdt",
"Ntp-lansoprazole",
"Ntp-lansoprazole",
"PMS-lansoprazole",
"PMS-lansoprazole",
"Preferred Plus Lansoprazole",
"Prevacid",
"Prevacid",
"Prevacid",
"Prevacid",
"Prevacid",
"Prevacid",
"Prevacid",
"Prevacid",
"Prevacid",
"Prevacid",
"Prevacid",
"Prevacid",
"Prevacid",
"Prevacid",
"Prevacid",
"Prevacid",
"Prevacid",
"Prevacid",
"Prevacid",
"Prevacid",
"Prevacid",
"Prevacid",
"Prevacid",
"Prevacid",
"Prevacid",
"Prevacid 24 HR",
"Prevacid 24 HR",
"Prevacid 24 HR",
"Prevacid 24 HR",
"Prevacid Fastab",
"Prevacid Fastab",
"Prevacid IV",
"Prevacid Naprapac",
"PREVACID NapraPAC 250",
"PREVACID NapraPAC 375",
"PREVACID NapraPAC 500",
"Prevacid SoluTab",
"Prevacid SoluTab",
"Prevacid SoluTab",
"Prevpac",
"Prevpac",
"Prevpac",
"Q-lansoprazole",
"Q-lansoprazole",
"Riva-lansoprazole",
"Riva-lansoprazole",
"Rugby Heartburn Treatment",
"Safeway Acid Reducer",
"Sandoz Lansoprazole",
"Sandoz Lansoprazole",
"ShopRite Lansoprazole",
"Signature Care Acid Reducer",
"Simply Right Lansoprazole",
"Smart Sense Acid Reducer",
"Smart Sense Lansoprazole",
"Sound Body Acid Reducer",
"Sunmark Lansoprazole",
"Sunmark Lansoprazole",
"Taro-lansoprazole",
"Taro-lansoprazole",
"Teva-lansoprazole",
"Teva-lansoprazole",
"Topcare Lansoprazole",
"topcare Lansoprazole",
"Topcare Lansoprazole",
"Up and Up Lansoprazole",
"Up and Up Lansoprazole",
"Well At Walgreens Lansoprazole"
] |
[
"Agopton",
"Bamalite",
"Lansoloc",
"Lanzol",
"Lanzopral",
"Lanzopran",
"Limpidex",
"Monolitum",
"Ogast",
"Ogastro",
"Opiren",
"Prevacid 24HR",
"Prosogan",
"Takepron",
"Ulpax",
"Zoprol",
"Zoton"
] |
[
"Prevacid Naprapac",
"Prevpac",
"Lansoprazole, Amoxicillin, and Clarithromycin",
"Prevpac",
"PREVACID NapraPAC 250",
"PREVACID NapraPAC 375",
"PREVACID NapraPAC 500",
"Lansoprazole, Amoxicillin, Clarithromycin",
"Lansoprazole, Amoxicillin and Clarithromycin",
"Prevpac",
"Lansoprazole, Amoxicillin and Clarithromycin",
"Hp-pac",
"Aa-lansoprazole-amoxicillin-clarithromycin"
] |
[
"P20648",
"P10636"
] |
[
"P04798",
"Q16678",
"P10632",
"P11712",
"P33260",
"P10635",
"P08684",
"P33261"
] |
[] |
[
"Q9UNQ0",
"P08183",
"Q8TCC7",
"O15245",
"O15244",
"O75751"
] |
DB00449
|
Dipivefrin
|
Dipivefrin is a prodrug of adrenaline, which is used to treat glaucoma. It is available as ophthalmic solution (eye drops).
|
solid
|
Dipivefrin is a prodrug which is used as initial therapy for the control of intraocular pressure in chronic open-angle glaucoma.
|
Dipivefrin is a member of a class of drugs known as prodrugs. Prodrugs are usually not active in themselves and require biotransformation to the parent compound before therapeutic activity is seen. These modifications are undertaken to enhance absorption, decrease side effects and enhance stability and comfort, thus making the parent compound a more useful drug. Enhanced absorption makes the prodrug a more efficient delivery system for the parent drug because less drug will be needed to produce the desired therapeutic response. Dipivefrin is a prodrug of epinephrine formed by the diesterification of epinephrine and pivalic acid. The addition of pivaloyl groups to the epinephrine molecule enhances its lipophilic character and, as a consequence, its penetration into the anterior chamber.
|
Dipivefrin is a prodrug with little or no pharmacologically activity until it is hydrolyzed into epinephrine inside the human eye. The liberated epinephrine, an adrenergic agonist, appears to exert its action by stimulating α -and/or β<sub>2</sub>-adrenergic receptors, leading to a decrease in aqueous production and an enhancement of outflow facility. The dipivefrin prodrug delivery system is a more efficient way of delivering the therapeutic effects of epinephrine, with fewer side effects than are associated with conventional epinephrine therapy.
|
Well absorbed following occular administration.
|
Dipivefrin is converted to epinephrine inside the human eye by enzyme hydrolysis.
|
Oral LD<sub>50</sub> in rat is 183 mg/kg.
| null | null | null | null | null |
Organic compounds
|
Benzenoids
|
Phenol esters
| null |
[
"approved"
] |
[
"S01EA",
"S01E",
"S01",
"S"
] |
[
"Humans and other mammals"
] |
[
{
"cost": "5.02",
"description": "Propine 0.1% eye drops",
"unit": "ml"
}
] |
[] |
(±)-4-[1-hydroxy-2-(methylamino)ethyl]-o-phenylene divavalate | 1-(3',4'-dipivaloyloxyphenyl)-2-methylamino-1-ethanol | 4-[1-hydroxy-2-(methylamino)ethyl]-o-phenylene divavalate | Dipivalyl epinephrine | Dipivefrin | Dipivefrina | Dipivefrine | Dipivéfrine | Dipivefrinum | ADRB1R | B1AR | Beta-1 adrenoceptor | Beta-1 adrenoreceptor | ADRA1C | Alpha-1A adrenoceptor | Alpha-1A adrenoreceptor | Alpha-1C adrenergic receptor | Alpha-adrenergic receptor 1c | ADRA2R | ADRAR | Alpha-2 adrenergic receptor subtype C10 | Alpha-2A adrenoceptor | Alpha-2A adrenoreceptor | Alpha-2AAR | ADRB2R | B2AR | Beta-2 adrenoceptor | Beta-2 adrenoreceptor | 3.1.1.8 | Acylcholine acylhydrolase | Butyrylcholine esterase | CHE1 | Choline esterase II | Pseudocholinesterase | 3.1.1.7 | AChE
|
[
"Apo-dipivefrin",
"Dipivefrin Hydrochloride",
"Dipivefrin Hydrochloride",
"Dipivefrin-liq Oph 0.1%",
"Dpe Ophthalmic Solution - 0.1%",
"PMS-dipivefrin",
"Probeta - Liq Oph",
"Propine",
"Propine Liq 0.1%",
"Ratio-dipivefrin"
] |
[
"AKPro",
"D Epifrin",
"Diopine",
"Pivalephrine",
"Pro-Epinephrine",
"Thilodrin"
] |
[
"Probeta - Liq Oph"
] |
[
"P08588",
"P35348",
"P08913",
"P07550",
"P06276",
"P22303"
] |
[] |
[] |
[] |
DB00450
|
Droperidol
|
A butyrophenone with general properties similar to those of haloperidol. It is used in conjunction with an opioid analgesic such as fentanyl to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon. It is also used as a premedicant, as an antiemetic, and for the control of agitation in acute psychoses. (From Martindale, The Extra Pharmacopoeia, 29th ed, p593)
|
solid
|
Droperidol is used to produce tranquilization and to reduce the incidence of nausea and vomiting in surgical and diagnostic procedures.
|
Droperidol produces marked tranquilization and sedation. It allays apprehension and provides a state of mental detachment and indifference while maintaining a state of reflex alertness. Droperidol produces an antiemetic effect as evidenced by the antagonism of apomorphine in dogs. It lowers the incidence of nausea and vomiting during surgical procedures and provides antiemetic protection in the postoperative period. Droperidol potentiates other CNS depressants. It produces mild alpha-adrenergic blockade, peripheral vascular dilatation and reduction of the pressor effect of epinephrine. It can produce hypotension and decreased peripheral vascular resistance and may decrease pulmonary arterial pressure (particularly if it is abnormally high). It may reduce the incidence of epinephrine-induced arrhythmias, but it does not prevent other cardiac arrhythmias.
|
The exact mechanism of action is unknown, however, droperidol causes a CNS depression at subcortical levels of the brain, midbrain, and brainstem reticular formation. It may antagonize the actions of glutamic acid within the extrapyramidal system. It may also inhibit cathecolamine receptors and the reuptake of neurotransmiters and has strong central antidopaminergic action and weak central anticholinergic action. It can also produce ganglionic blockade and reduced affective response. The main actions seem to stem from its potent Dopamine(2) receptor antagonism with minor antagonistic effects on alpha-1 adrenergic receptors as well.
|
Completely absorbed following intramuscular administration.
|
Extensively metabolized.
|
The intravenous LD<sub>50</sub> of droperidol is 20-43 mg/kg in mice; 30 mg/kg in rats; 25 mg/kg in dogs and 11-13 mg/kg in rabbits. The intramuscular LD<sub>50</sub> of droperidol is 195 mg/kg in mice, 104-110 mg/kg in rats; 97 mg/kg in rabbits and 200 mg/kg in guinea pigs. The manifestations of droperidol overdosage are an extension of its pharmacologic actions.
|
Biphasic distribution. The rapid distribution phase is 1.4 ± 0.5 minutes and the slower distribution phase is 14.3 ± 6.5 minutes. Elimination half-life in adults is 134 ± 13 minutes and may be increased in geriatric patients. In children, it is 101.5 ± 26.4 minutes.
| null | null | null | null |
Organic compounds
|
Organic oxygen compounds
|
Organooxygen compounds
|
Carbonyl compounds
|
[
"approved",
"vet_approved"
] |
[
"N05AD",
"N05A",
"N05",
"N"
] |
[
"Humans and other mammals"
] |
[
{
"cost": "2.04",
"description": "Droperidol 2.5 mg/ml vial",
"unit": "ml"
},
{
"cost": "4.59",
"description": "Inapsine 2.5 mg/ml ampul",
"unit": "ml"
},
{
"cost": "0.7",
"description": "Droperidol 2.5 mg/ml ampul",
"unit": "ml"
}
] |
[] |
1-(1-(3-(p-fluorobenzoyl)propyl)-1,2,3,6-tetrahydro-4-pyridyl)-2-benzimidazolinone | 1-(1-(4-(p-fluorophenyl)-4-oxobutyl)-1,2,3,6-tetrahydro-4-pyridyl)-2-benzimidazolinone | 1-{1-[4-(4-Fluoro-phenyl)-4-oxo-butyl]-1,2,3,6-tetrahydro-pyridin-4-yl}-1,3-dihydro-benzoimidazol-2-one | 1-{1-[4-(4-fluorophenyl)-4-oxobutyl]-1,2,3,6-tetrahydro-4-pyridinyl}-2,3-dihydro-1H-benzo[d]imidazol-2-one | Droperidol | Dropéridol | Droperidolo | Droperidolum | ADRA1C | Alpha-1A adrenoceptor | Alpha-1A adrenoreceptor | Alpha-1C adrenergic receptor | Alpha-adrenergic receptor 1c | Dopamine D2 receptor
|
[
"Droperidol",
"Droperidol",
"Droperidol",
"Droperidol",
"Droperidol",
"Droperidol",
"Droperidol",
"Droperidol Injection",
"Droperidol Injection USP 2.5mg/ml",
"Inapsine",
"Inapsine",
"Inapsine",
"Inapsine",
"Inapsine Inj 2.5mg/ml",
"Innovar Inj"
] |
[
"Dehydrobenzperidol",
"Dridol",
"Droleptan",
"Dropedol",
"Dropel",
"Droperdal",
"Droperidols",
"Xomolix"
] |
[
"Innovar Inj"
] |
[
"P35348",
"P14416"
] |
[] |
[] |
[] |
DB00454
|
Meperidine
|
A narcotic analgesic that can be used for the relief of most types of moderate to severe pain, including postoperative pain and the pain of labor. Prolonged use may lead to dependence of the morphine type; withdrawal symptoms appear more rapidly than with morphine and are of shorter duration.
|
solid
|
Used to control moderate to severe pain.
|
Meperidine is a synthetic opiate agonist belonging to the phenylpiperidine class. Meperidine may produce less smooth muscle spasm, constipation, and depression of the cough reflex than equivalent doses of morphine. The onset of action is lightly more rapid than with morphine, and the duration of action is slightly shorter. The chemical structure of meperidine is similar to local anesthetics. Meperidine is recommended for relief of moderate to severe acute pain and has the unique ability to interrupt postoperative shivering and shaking chills induced by amphotericin B. Meperidine has also been used for intravenous regional anesthesia, peripheral nerve blocks and intraarticular, epidural and spinal analgesia. Meperidine is considered a second-line agent for the treatment of acute pain.
|
Meperidine is primarily a kappa-opiate receptor agonist and also has local anesthetic effects. Meperidine has more affinity for the kappa-receptor than morphine. Opiate receptors are coupled with G-protein receptors and function as both positive and negative regulators of synaptic transmission via G-proteins that activate effector proteins. Binding of the opiate stimulates the exchange of GTP for GDP on the G-protein complex. As the effector system is adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine and noradrenaline is inhibited. Opioids also inhibit the release of vasopressin, somatostatin, insulin and glucagon. Opioids close N-type voltage-operated calcium channels (OP2-receptor agonist) and open calcium-dependent inwardly rectifying potassium channels (OP3 and OP1 receptor agonist). This results in hyperpolarization and reduced neuronal excitability.
|
The oral bioavailability of meperidine in patients with normal hepatic function is 50-60% due to extensive first-pass metabolism. Bioavailability increases to 80-90% in patients with hepatic impairment (e.g. liver cirrhosis). Meperidine is less than half as effective when administered orally compared to parenteral administration. One study reported that 80-85% of the drug administered intramuscularly was absorbed within 6 hours of intragluteal injection in health adults; however, inter-individual variation and patient-specific variable appear to cause considerable variations in absorption upon IM injection.
|
Meperidine is metabolized in the liver by hydrolysis to meperidinic acid followed by partial conjugation with glucuronic acid. Meperidine also undergoes N-demethylation to normeperidine, which then undergoes hydrolysis and partial conjugation. Normeperidine is about half as potent as meperidine, but it has twice the CNS stimulation effects.
| null |
Initial distribution phase (t<sub>1/2 α</sub>) = 2-11 minutes; terminal elimination phase (t<sub>1/2 β</sub>) = 3-5 hours. In patients with hepatic dysfunction (e.g. liver cirrhosis or active viral hepatitis) the t<sub>1/2 β</sub> is prolonged to 7-11 hours.
|
60-80% bound to plasma proteins, primarily albumin and α<sub>1</sub>-acid glycoprotein. The presence of cirrhosis or active viral hepatitis does not appear to affect the extent of protein binding.
|
Excreted in the urine. The proportion of drug that is excreted unchanged or as metabolites is dependent on pH. When urine pH is uncontrolled, 5-30% of the meperidine dose is excreted as normeperidine and approximately 5% is excreted unchanged. Meperidine and normeperidine are found in acidic urine, while the free and conjugated forms of meperidinic and normperidinic acids are found in alkaline urine.
|
Meperidine crosses the placenta and is distributed into breast milk.
| null |
Organic compounds
|
Organoheterocyclic compounds
|
Piperidines
|
Phenylpiperidines
|
[
"approved"
] |
[
"N02AB",
"N02A",
"N02",
"N",
"N02AB",
"N02A",
"N02",
"N",
"N02AB",
"N02A",
"N02",
"N",
"N02AG",
"N02A",
"N02",
"N"
] |
[
"Humans and other mammals"
] |
[
{
"cost": "1.04",
"description": "Meperidine Hydrochloride 75 mg/ml",
"unit": "ml"
},
{
"cost": "1.1",
"description": "Demerol 100 mg/ml ampul",
"unit": "ml"
},
{
"cost": "1.1",
"description": "Meperidine Hydrochloride 100 mg/ml",
"unit": "ml"
},
{
"cost": "1.31",
"description": "Meperidine 100 mg tablet",
"unit": "tablet"
},
{
"cost": "1.33",
"description": "Meperidine HCl 100 mg tablet",
"unit": "tablet"
},
{
"cost": "1.71",
"description": "Demerol 50 mg tablet",
"unit": "tablet"
},
{
"cost": "1.79",
"description": "Demerol 100 mg/ml vial",
"unit": "ml"
},
{
"cost": "3.33",
"description": "Demerol 100 mg tablet",
"unit": "tablet"
},
{
"cost": "10.51",
"description": "Meperidine hcl powder",
"unit": "g"
},
{
"cost": "33.99",
"description": "Meperidine HCl 100 mg/ml vial",
"unit": "vial"
},
{
"cost": "0.14",
"description": "Meperidine HCl 50 mg/5ml Solution",
"unit": "ml"
},
{
"cost": "0.16",
"description": "Demerol 50 mg Tablet",
"unit": "tablet"
},
{
"cost": "0.3",
"description": "Meperidine 10 mg/ml cartrdge",
"unit": "ml"
},
{
"cost": "0.58",
"description": "Demerol 50 mg/ml ampul",
"unit": "ml"
},
{
"cost": "0.69",
"description": "Meperidine 50 mg tablet",
"unit": "tablet"
},
{
"cost": "0.85",
"description": "Demerol 50 mg/ml vial",
"unit": "ml"
},
{
"cost": "0.85",
"description": "Meperidine 10 mg/ml syringe",
"unit": "ml"
},
{
"cost": "0.93",
"description": "Meperidine HCl 50 mg tablet",
"unit": "tablet"
},
{
"cost": "0.98",
"description": "Meperidine Hydrochloride 50 mg/ml",
"unit": "ml"
}
] |
[] |
Isonipecaïne | Meperidina | Pethidin | Pethidine | Péthidine | Pethidinum | Petidina | Petydyna | K-OR-1 | KOR-1 | OPRK | GluN1 | Glutamate [NMDA] receptor subunit zeta-1 | hNR1 | N-methyl-D-aspartate receptor subunit NR1 | NMD-R1 | NMDAR1 | GluN2B | Glutamate [NMDA] receptor subunit epsilon-2 | hNR3 | N-methyl D-aspartate receptor subtype 2B | N-methyl-D-aspartate receptor subunit 3 | NMDAR2B | NR2B | NR3 | GluN2A | Glutamate [NMDA] receptor subunit epsilon-1 | hNR2A | N-methyl D-aspartate receptor subtype 2A | NMDAR2A | NR2A | GluN2C | Glutamate [NMDA] receptor subunit epsilon-3 | N-methyl D-aspartate receptor subtype 2C | NMDAR2C | NR2C | EB11 | GluN2D | Glutamate [NMDA] receptor subunit epsilon-4 | N-methyl D-aspartate receptor subtype 2D | NMDAR2D | NR2D | hMOP | M-OR-1 | MOP | MOR-1 | MOR1 | Mu opiate receptor | Mu opioid receptor | DA transporter | DAT | DAT1 | Solute carrier family 6 member 3 | NAT1 | NET | NET1 | Norepinephrine transporter | SLC6A5 | Solute carrier family 6 member 2 | 5HT transporter | 5HTT | HTT | SERT | Solute carrier family 6 member 4 | ACAT | Acyl-coenzyme A:cholesterol acyltransferase | Brain carboxylesterase hBr1 | Carboxylesterase 1 | CE-1 | CEH | CES2 | Cholesteryl ester hydrolase | Cocaine carboxylesterase | Egasyn | hCE-1 | HMSE | Methylumbelliferyl-acetate deacetylase 1 | Monocyte/macrophage serine esterase | REH | Retinyl ester hydrolase | Serine esterase 1 | SES1 | TGH | Triacylglycerol hydrolase | 1,4-cineole 2-exo-monooxygenase | 1,8-cineole 2-exo-monooxygenase | 1.14.14.1 | Albendazole monooxygenase (sulfoxide-forming) | Albendazole sulfoxidase | Cholesterol 25-hydroxylase | CYP3A3 | CYPIIIA3 | CYPIIIA4 | Cytochrome P450 3A3 | Cytochrome P450 HLp | Cytochrome P450 NF-25 | Cytochrome P450-PCN1 | Nifedipine oxidase | Quinine 3-monooxygenase | (R)-limonene 6-monooxygenase | (S)-limonene 6-monooxygenase | (S)-limonene 7-monooxygenase | 1.14.14.1 | CYPIIC17 | CYPIIC19 | Cytochrome P450-11A | Cytochrome P450-254C | Fenbendazole monooxygenase (4'-hydroxylating) | Mephenytoin 4-hydroxylase | 1,4-cineole 2-exo-monooxygenase | 1.14.13.- | CYPIIB6 | Cytochrome P450 IIB1 | 1.14.14.- | Cholesterol 25-hydroxylase | CYP2DL1 | CYPIID6 | Cytochrome P450-DB1 | Debrisoquine 4-hydroxylase | 1.14.14.1 | Cholesterol 25-hydroxylase | CYPIA2 | Cytochrome P(3)450 | Cytochrome P450 4 | Cytochrome P450-P3 | Hydroperoxy icosatetraenoate dehydratase | AGP 1 | AGP1 | OMD 1 | Orosomucoid-1 | ATP-binding cassette sub-family B member 1 | MDR1 | Multidrug resistance protein 1 | P-glycoprotein 1 | PGY1 | Phospholipid transporter ABCB1
|
[
"Demerol",
"Demerol",
"Demerol",
"Demerol",
"Demerol",
"Demerol",
"Demerol",
"Demerol",
"Demerol",
"Demerol",
"Demerol",
"Demerol",
"Demerol",
"Demerol",
"Demerol",
"Demerol",
"Demerol",
"Demerol",
"Demerol",
"Demerol",
"Demerol",
"Demerol",
"Demerol",
"Demerol",
"Demerol",
"Demerol",
"Demerol",
"Demerol",
"Demerol",
"Demerol",
"Demerol",
"Demerol",
"Demerol",
"Demerol 10%-liq Im IV Sc",
"Demerol 10%-liq Im Sc 100mg/ml",
"Demerol 100 mg/ml",
"Demerol 100 mg/ml",
"Demerol 50 mg/ml (multiple Dose With Metacresol As Preservative)",
"Demerol 50 mg/ml (single Use, Preservative Free)",
"Demerol 50mg - Liq Im IV Sc 50mg/ml",
"Demerol 50mg - Liq Im Sc 50mg/ml",
"Demerol 75 mg/ml",
"Demerol 75mg - Liq Im IV Sc 75mg/ml",
"Meperidine HCl",
"Meperidine HCl",
"Meperidine HCl",
"Meperidine Hcl and Promethazine Hcl",
"Meperidine HCl Injection 100mg/ml",
"Meperidine HCl Injection 10mg/ml",
"Meperidine HCl Injection 25mg/ml",
"Meperidine HCl Injection 50mg/ml",
"Meperidine HCl Injection 75mg/ml",
"Meperidine Hydrochloride",
"Meperidine Hydrochloride",
"Meperidine Hydrochloride",
"Meperidine Hydrochloride",
"Meperidine Hydrochloride",
"Meperidine Hydrochloride",
"Meperidine Hydrochloride",
"Meperidine Hydrochloride",
"Meperidine Hydrochloride",
"Meperidine Hydrochloride",
"Meperidine Hydrochloride",
"Meperidine Hydrochloride",
"Meperidine Hydrochloride",
"Meperidine Hydrochloride",
"Meperidine Hydrochloride",
"Meperidine Hydrochloride",
"Meperidine Hydrochloride",
"Meperidine Hydrochloride",
"Meperidine Hydrochloride",
"Meperidine Hydrochloride",
"Meperidine Hydrochloride",
"Meperidine Hydrochloride",
"Meperidine Hydrochloride",
"Meperidine Hydrochloride",
"Meperidine Hydrochloride",
"Meperidine Hydrochloride",
"Meperidine Hydrochloride",
"Meperidine Hydrochloride",
"Meperidine Hydrochloride",
"Meperidine Hydrochloride",
"Meperidine Hydrochloride",
"Meperidine Hydrochloride",
"Meperidine Hydrochloride",
"Meperidine Hydrochloride",
"Meperidine Hydrochloride",
"Meperidine Hydrochloride",
"Meperidine Hydrochloride",
"Meperidine Hydrochloride and Promethazine Hydrochloride",
"Meperidine Hydrochloride Injection USP",
"Meperidine Hydrochloride Injection USP",
"Meperidine Hydrochloride Injection USP",
"Meperidine Hydrochloride Injection USP",
"Pethidine Injection B.P."
] |
[
"Dolantin",
"Dolcontral",
"Dolosal",
"Dolsin",
"Lydol",
"Mialgin",
"Petidin"
] |
[
"Meperidine Hcl and Promethazine Hcl",
"Meperidine Hydrochloride and Promethazine Hydrochloride"
] |
[
"P41145",
"Q05586",
"Q13224",
"Q12879",
"Q14957",
"O15399",
"P11229",
"P08172",
"P20309",
"P08173",
"P08912",
"P35372",
"Q01959",
"P23975",
"P31645",
"P23141"
] |
[
"P08684",
"P33261",
"P20813",
"P10635",
"P05177"
] |
[
"P02768",
"P02763"
] |
[
"P08183"
] |
DB00455
|
Loratadine
|
Loratadine is a second generation antihistamine used to manage symptoms of allergic rhinitis.[A176435] A lack of sedative and CNS adverse effects make loratadine, along with other second generation antihistamines, preferable over their 1st generation counterparts in many clinical situations.[A176441]
|
solid
|
Loratadine is a 2nd generation antihistamine and is used to manage symptoms of allergic rhinitis, wheal formation, urticaria, and other allergic dermatologic conditions.[A176435][A176438][L8486]
|
Like other 2nd generation antihistamines, loratadine is selective for peripheral H1 receptors.[A5506] Loratadine does not penetrate effectively into the central nervous system and has poor affinity for CNS H1-receptors.[A5506] These qualities result in a lack of CNS depressant effects such as drowsiness, sedation, and impaired psychomotor function.[A5506]
|
Histamine release is a key mediator in allergic rhinitis and urticaria.[A185312][A176441][A175060] As a result, loratadine exerts it's effect by targeting H1 histamine receptors.
Loratadine binds to H1 histamine receptors found on the surface of epithelial cells, endothelial cells, eosinophils, neutrophils, airway cells, and vascular smooth muscle cells among others.[A176441] H1 histamine receptors fall under the wider umbrella of G-protein coupled receptors, and exist in a state of equilibrium between the active and inactive forms.[A176441][A175060] Histamine binding to the H1-receptor facilitates cross linking between transmembrane domains III and V, stabilizing the active form of the receptor.[A176441][A175060] On the other hand, antihistamines bind to a different site on the H1 receptor favouring the inactive form.[A176441][A175060]
Hence, loratadine can more accurately be classified as an "inverse agonist" as opposed to a "histamine antagonist", and can prevent or reduce the severity of histamine mediated symptoms.[A176441][A175060][L8486]
|
Loratadine is rapidly absorbed and achieves peak plasma concentration in 1-2 hours, while it's main metabolite achieves peak plasma concentration in 3-4 hours.[A176438]
In the rapid dissolve formulation, the pharmacokinetic parameters of loratadine are as follows[L8486]: Cmax = 2.56 ng/ml, Tmax = 1.14 hrs, AUC = 6.14 ng x hr/ml.
In the rapid dissolve formulation, the pharmacokinetic parameters of descarboethoxyloratadine are as follows[L8486]: Cmax = 3.72 ng/ml, Tmax = 1.97 hr, AUC = 49.1 ng x hr/ml.
In the conventional formulation, the pharmacokinetic parameters of loratadine are as follows[L8486]: Cmax = 2.11 ng/ml, Tmax = 1.00 hr, AUC = 4.64 ng x hr/ml
In the conventional formulation, the pharmacokinetic parameters of descarboethoxyloratadine are as follows[L8486]: Cmax = 3.66 ng/ml, Tmax = 1.97 hr, AUC = 48.4 ng x hr/ml
|
Loratadine undergoes extensive first pass metabolism in the liver and is primarily metabolized by CYP3A4, CYP2D6, CYP1A1 and CYP2C19. Less involved CYP enzymes include CYP1A2, CYP2B6, CYP2C8, CYP2C9 and CYP3A5.[A38842][A176444] CYP3A4 and CYP2D6 are mainly responsible for metabolizing loratadine to descarboethoxyloratadine.[A176444] This primary metabolite is 4 times more pharmacologically active than loratadine.[A176438]
In addition, a study demonstrates that descarboethoxyloratadine is first glucuronidated by UGT2B10, then hydroxylated by CYP2C8 to form 3-hydroxydesloratadine.[A185855] Further glucuronidation of 3-hydroxydesloratadine facilitates excretion.[A185843]
|
Second generation antihistamines such as loratadine have very few adverse effects; however, insomnia, headache, fatigue, drowsiness and rash have been reported.[A176441] Symptoms of loratadine overdose include gastrointestinal side effects, agitation, drowsiness, tachycardia, and headache.[A176441] It is advised to obtain an ECG in the event of loratadine overdose.[A176441]
|
The elimination half life is approximately 10 hours for loratadine and 20 hours for descarboethoxyloratadine.[A176438]
|
97 - 99% of the loratadine is bound to plasma proteins.[L8486]
|
Over a 10 day period, 40% of loratadine is excreted in the urine, and 42% is eliminated in the faeces.[L8486]
|
The volume of distribution of loratadine is 120 L/Kg.[L8618]
|
The clearance of loratadine after single oral doses of 20 mg and 40 mg are 12 L/h/kg and 9 L/h/kg respectively.[A5506]
P-glycoprotein is involved in the clearance of many 2nd generation antihistamines, including loratadine, from the central nervous system. 1st generation antihistamines are not cleared by P-glycoprotein, which may help explain why they have a different central nervous system adverse effect profile compared to their 2nd generation counterparts.[L8618][A175075] It appears that an antihistamine with higher affinity for p-glycoprotein will have a lower incidence of CNS adverse effects.[A175072]
|
Organic compounds
|
Organoheterocyclic compounds
|
Benzocycloheptapyridines
| null |
[
"approved",
"investigational"
] |
[
"R06AX",
"R06A",
"R06",
"R"
] |
[
"Humans and other mammals"
] |
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[
{
"approved": "2000-10-17",
"country": "United States",
"expires": "2018-06-01",
"number": "6132758"
}
] |
Loratadina | Loratadine | Loratadinum | H1-R | H1R | HH1R | Eag homolog | Eag-related protein 1 | ERG | ERG-1 | ERG1 | Ether-a-go-go-related gene potassium channel 1 | Ether-a-go-go-related protein 1 | H-ERG | HERG | hERG-1 | hERG1 | Potassium voltage-gated channel subfamily H member 2 | Voltage-gated potassium channel subunit Kv11.1 | 1,4-cineole 2-exo-monooxygenase | 1,8-cineole 2-exo-monooxygenase | 1.14.14.1 | Albendazole monooxygenase (sulfoxide-forming) | Albendazole sulfoxidase | Cholesterol 25-hydroxylase | CYP3A3 | CYPIIIA3 | CYPIIIA4 | Cytochrome P450 3A3 | Cytochrome P450 HLp | Cytochrome P450 NF-25 | Cytochrome P450-PCN1 | Nifedipine oxidase | Quinine 3-monooxygenase | 1.14.14.- | Cholesterol 25-hydroxylase | CYP2DL1 | CYPIID6 | Cytochrome P450-DB1 | Debrisoquine 4-hydroxylase | 1.14.14.1 | CYPIA1 | Cytochrome P450 form 6 | Cytochrome P450-C | Cytochrome P450-P1 | Hydroperoxy icosatetraenoate dehydratase | (R)-limonene 6-monooxygenase | (S)-limonene 6-monooxygenase | (S)-limonene 7-monooxygenase | 1.14.14.1 | CYPIIC17 | CYPIIC19 | Cytochrome P450-11A | Cytochrome P450-254C | Fenbendazole monooxygenase (4'-hydroxylating) | Mephenytoin 4-hydroxylase | 1.14.14.1 | CYPIIC8 | Cytochrome P450 form 1 | Cytochrome P450 IIC2 | Cytochrome P450 MP-12 | Cytochrome P450 MP-20 | S-mephenytoin 4-hydroxylase | 1.14.14.1 | Cholesterol 25-hydroxylase | CYPIA2 | Cytochrome P(3)450 | Cytochrome P450 4 | Cytochrome P450-P3 | Hydroperoxy icosatetraenoate dehydratase | 1,4-cineole 2-exo-monooxygenase | 1.14.13.- | CYPIIB6 | Cytochrome P450 IIB1 | (R)-limonene 6-monooxygenase | (S)-limonene 6-monooxygenase | (S)-limonene 7-monooxygenase | 1.14.14.1 | Cholesterol 25-hydroxylase | CYP2C10 | CYPIIC9 | Cytochrome P-450MP | Cytochrome P450 MP-4 | Cytochrome P450 MP-8 | Cytochrome P450 PB-1 | S-mephenytoin 4-hydroxylase | 1.14.14.1 | CYPIIIA5 | Cytochrome P450-PCN3 | 2.4.1.17 | UDPGT 2B10 | 2.4.1.17 | Bilirubin-specific UDPGT isozyme 1 | GNT1 | hUG-BR1 | UDP-glucuronosyltransferase 1-1 | UDP-glucuronosyltransferase 1A isoform 1 | UDPGT 1-1 | UGT1 | UGT1-01 | UGT1.1 | UGT1*1 | UGT1A1 | 2.4.1.17 | GNT1 | UDP-glucuronosyltransferase 1-3 | UDP-glucuronosyltransferase 1-C | UDP-glucuronosyltransferase 1A isoform 3 | UDPGT 1-3 | UGT-1C | UGT1 | UGT1-03 | UGT1.3 | UGT1*3 | UGT1A3 | UGT1C | 2.4.1.17 | HLUG4 | UDP-glucuronosyltransferase 2B8 | UDPGT 2B15 | UDPGT 2B8 | UDPGTh-3 | UGT2B15 | UGT2B8 | ATP-binding cassette sub-family B member 1 | MDR1 | Multidrug resistance protein 1 | P-glycoprotein 1 | PGY1 | Phospholipid transporter ABCB1 | 7.6.2.- | ATP-binding cassette sub-family B member 11 | BSEP
|
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"Childrens Allergy Relief",
"Childrens Allergy Relief",
"Childrens Allergy Relief",
"Childrens Allergy Relief",
"Childrens Allergy Relief",
"Childrens Allergy Relief",
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"childrens allergy Sugar Free",
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"Leader Allergy Relief",
"Leader allergy relief",
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"Leader Allergy Relief D-24",
"Leader Allergy Relief D12",
"Leader Childrens Allergy Relief",
"Leader Childrens Allergy Relief",
"LEADER Loratadine",
"Liberator",
"Lil Drug Store Claritin Non-Drowsy, 24 Hour",
"Live Better Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine",
"Loratadine 10mg",
"Loratadine 10mg",
"Loratadine Allergy Relief",
"Loratadine Allergy Relief",
"Loratadine Allergy Relief",
"Loratadine Allergy Relief",
"Loratadine Allergy Relief",
"Loratadine Allergy Relief",
"Loratadine Allergy Relief",
"Loratadine Allergy Relief",
"Loratadine Allergy Relief",
"Loratadine Allergy Relief",
"Loratadine Allergy Relief",
"Loratadine Allergy Relief",
"Loratadine Allergy Relief",
"Loratadine Allergy Relief",
"Loratadine Allergy Relief",
"Loratadine Allergy Relief",
"Loratadine Allergy Relief",
"Loratadine Allergy Relief",
"Loratadine Allergy Relief",
"Loratadine Allergy Relief",
"Loratadine Allergy Relief",
"Loratadine Allergy Relief",
"Loratadine Allergy Relief",
"Loratadine Allergy Relief",
"Loratadine Allergy Relief",
"LORATADINE ALLERGY RELIEF 10mg",
"Loratadine and Pseudoephedrine",
"Loratadine and Pseudoephedrine",
"Loratadine and Pseudoephedrine",
"Loratadine and Pseudoephedrine",
"Loratadine and Pseudoephedrine",
"Loratadine and Pseudoephedrine",
"Loratadine and Pseudoephedrine",
"Loratadine and Pseudoephedrine",
"Loratadine and Pseudoephedrine",
"Loratadine and Pseudoephedrine",
"Loratadine and Pseudoephedrine",
"Loratadine and Pseudoephedrine",
"Loratadine and Pseudoephedrine",
"Loratadine and Pseudoephedrine",
"Loratadine and Pseudoephedrine",
"Loratadine and Pseudoephedrine",
"Loratadine and Pseudoephedrine",
"Loratadine and Pseudoephedrine Sulfate",
"Loratadine and Pseudoephedrine Sulfate",
"Loratadine and Pseudoephedrine Sulfate",
"Loratadine and Pseudoephedrine Sulfate",
"Loratadine and Pseudoephedrine Sulfate",
"Loratadine and Pseudoephedrine Sulfate",
"Loratadine and Pseudoephedrine Sulfate",
"Loratadine and Pseudoephedrine Sulfate",
"Loratadine and Pseudoephedrine Sulfate",
"Loratadine and Pseudoephedrine Sulfate",
"Loratadine and Pseudoephedrine Sulfate",
"Loratadine and Pseudoephedrine Sulfate",
"Loratadine and Pseudoephedrine Sulfate",
"Loratadine and Pseudoephedrine Sulfate",
"Loratadine and Pseudoephedrine Sulfate",
"Loratadine and Pseudoephedrine Sulfate",
"Loratadine and Pseudoephedrine Sulfate",
"Loratadine and Pseudoephedrine Sulfate",
"Loratadine and Pseudoephedrine Sulfate",
"Loratadine and Pseudoephedrine Sulfate",
"Loratadine antihistamine",
"Loratadine antihistamine",
"Loratadine Antihistamine",
"Loratadine antihistamine",
"Loratadine antihistamine",
"Loratadine antihistamine",
"Loratadine antihistamine",
"Loratadine antihistamine",
"Loratadine antihistamine",
"Loratadine antihistamine",
"Loratadine antihistamine",
"Loratadine antihistamine",
"Loratadine antihistamine",
"Loratadine antihistamine",
"Loratadine antihistamine",
"Loratadine antihistamine",
"Loratadine antihistamine",
"Loratadine antihistamine",
"Loratadine antihistamine",
"Loratadine antihistamine",
"Loratadine antihistamine",
"Loratadine antihistamine",
"Loratadine antihistamine",
"Loratadine antihistamine",
"Loratadine antihistamine",
"Loratadine antihistamine",
"Loratadine antihistamine",
"loratadine D",
"Loratadine D",
"Loratadine D",
"Loratadine D 24 Hour",
"Loratadine Non drowsy",
"Loratadine OD",
"Loratadine ODT",
"Loratadine ODT",
"Loratadine ODT",
"Loratadine ODT",
"Loratadine ODT",
"Loratadine ODT",
"Loratadine ODT",
"Loratadine ODT",
"Loratadine ODT",
"Loratadine ODT",
"Loratadine ODT",
"Loratadine ODT",
"Loratadine ODT",
"Loratadine ODT",
"Loratadine ODT",
"Loratadine ODT",
"Loratadine ODT",
"Loratadine ODT",
"Loratadine ODT",
"Loratadine ODT",
"Loratadine ODT",
"Loratadine Soft Gel Capsules",
"Loratadine Soft Gelatin Capsules",
"Loratadine Softgels",
"Loratadine Tablets 10mg",
"Loratadineantihistamine antihistamine",
"Loratadineantihistamine antihistamine",
"McKesson Loratadine",
"Medi First Plus Allergy Relief",
"Medi-First Plus Allery Relief",
"Medicine Shoppe Allergy Relief D24",
"Medicine Shoppe Loratadine Allergy Relief",
"MEDIQUE Loradamed",
"Medique Loradamed",
"meijer Childrens 24 Hour Allergy",
"Members Mark Aller-itin",
"Members Mark Allergy Relief",
"Members Mark Loratadine",
"Moore Medical Loratadine",
"Nazirex Compounding Kit",
"Non Drowsy Allergy Relief",
"Non-Drowsy Allergy Relief",
"Non-Drowsy Allergy Relief, 24-7 Life",
"Novo-loratadine",
"Perrigo Allergy D",
"Picnic Antihistamine",
"Picnic Nasal Decongestant and Antihistamine",
"Preferred Plus (Kinray) Childrens Loratadine",
"Preferred Plus Allergy and Congestion Relief",
"Preferred Plus Allergy Relief",
"Premier Value Childrens Loratadine",
"Premier Value Childrens Loratadine",
"Quality Choice Childrens Allergy Relief",
"Quality Choice Childrens Allergy Relief",
"Rexall Allergy Relief Non Drowsy",
"Shoprite Allergy and Congestion Relief",
"ShopRite Allergy Relief",
"Signature Care Allergy and Congestion Relief",
"Signature Care Allergy and Congestion Relief",
"Signature Care Allergy Relief",
"Signature Care Allergy Relief",
"Signature Care Allergy Relief",
"Simply Right Loratadine",
"Smart Sense Allergy and Congestion Relief",
"Smart Sense Allergy and Congestion Relief",
"Smart Sense Allergy and Congestion Relief D",
"Smart Sense allergy and congestion relief indoor and outdoor allergies",
"Smart Sense Allergy and Congestion Relief-D",
"Smart Sense Allergy Relief non drowsy",
"Sound Body Allergy Relief",
"Sunmark Allergy Relief",
"Sunmark childrens loratadine",
"sunmark Childrens Loratadine",
"Sunmark childrens loratadine",
"Sunmark Childrens Loratadine Srp Sf Grape",
"Sunmark Childrens Loratadine Srp Sf Grape",
"Sunmark Loratadine",
"Sunmark Loratadine",
"Sunmark Loratadine",
"Sunmark Loratadine allergy relief",
"Sunmark Loratadine D",
"Sunmark Loratadine D",
"Sunmark Loratadine ODT",
"Sunmark Loratadine ODT",
"Taro-loratadine",
"Topcare Allergy and Congestion Relief",
"Topcare Allergy and Congestion Relief",
"Topcare Allergy Relief",
"Topcare Allergy Relief",
"Topcare Allergy Relief",
"Topcare Allergy Relief",
"TopCare Allergy Relief 24 hour",
"Topcare Allergy Relief D",
"TopCare Allergy Relief D",
"Topcare Childrens Allergy",
"Topcare Childrens Allergy Relief",
"Topcare childrens allergy relief 24 hour non drowsy",
"TopCare Childrens Loratadine",
"Topcare Clear Time",
"Up and Up allergy and congestion relief",
"Up and Up Allergy Plus Congestion Relief D",
"Up and Up Allergy Relief",
"Up and Up Allergy Relief",
"Up and Up Childrens Allergy",
"Up and Up Childrens Allergy Relief",
"Vicks QlearQuil All Day And All Night 24 Hour Allergy Relief",
"Wal Itin",
"Wal itin",
"Wal Itin D",
"Wal itin D",
"Wal itin D 12 hour allergy and congestion",
"Wal Itin D Non Drowsy",
"Wal itin D non drowsy",
"Wal Itin D Non Drowsy 24 Hour Allergy and Congestion",
"Wal-itin",
"Wal-itin",
"Wal-itin",
"Wal-itin",
"Wal-itin Allergy Relief",
"Wal-itin D 24 Hour",
"Welby All Day Allergy Relief",
"Welby Childrens Allergy Relief",
"Welby health allergy relief",
"Western Family Childrens Allergy Relief",
"XL - 3 Allergy"
] |
[
"Aerotina",
"Alavert",
"Biloina",
"Civeran",
"Fristamin",
"Histaloran",
"Lomilan",
"Loracert",
"Loradex",
"Loranox",
"Lorastine",
"Loratyne",
"Loritine",
"Nularef",
"Restamine",
"Roletra",
"Sensibit"
] |
[
"Loratadine and Pseudoephedrine",
"Allergy and Congestion Relief Non Drowsy",
"Alavert Allergy Sinus D-12",
"Loratadine and Pseudoephedrine",
"Loratadine and Pseudoephedrine Sulfate",
"Loratadine and Pseudoephedrine Sulfate",
"Leader Allergy Relief D-24",
"Loratadine and Pseudoephedrine Sulfate",
"Medicine Shoppe Allergy Relief D24",
"Loratadine and Pseudoephedrine",
"Loratadine and Pseudoephedrine Sulfate",
"Loratadine and Pseudoephedrine Sulfate",
"Claritin-D 12 Hour",
"Allergy Relief D",
"Allergy and congestion relief",
"Nazirex Compounding Kit",
"Allergy Relief D",
"Harris Teeter Allergy and Congestion Relief",
"Topcare Allergy Relief D",
"TopCare Allergy Relief D",
"AlloPAX",
"Loratadine and Pseudoephedrine Sulfate",
"Allergy and Congestion Relief Non Drowsy",
"Allergy and Congestion Relief",
"Up and Up allergy and congestion relief",
"Up and Up Allergy Plus Congestion Relief D",
"Preferred Plus Allergy and Congestion Relief",
"Allergy and Congestion Relief",
"Allergy Relief D 24 Hour",
"Wal Itin D Non Drowsy",
"Wal Itin D",
"Wal itin D",
"Kirkland Signature Allerclear D 24hr",
"Good Sense Allergy and Congestion Relief",
"Good Neighbor Pharmacy loratadine d 24 hour",
"Shoprite Allergy and Congestion Relief",
"Allergy Relief D",
"Loratadine and Pseudoephedrine Sulfate",
"Smart Sense Allergy and Congestion Relief",
"Smart Sense Allergy and Congestion Relief",
"Healthy Accents Allergy and Congestion Relief 24 Hour Non Drowsy",
"Smart Sense Allergy and Congestion Relief-D",
"Loratadine and Pseudoephedrine",
"Claritin-D 24 Hour",
"Wal itin D non drowsy",
"Allergy Relief D",
"Allergy and Congestion Relief",
"KIRKLAND SIGNATURE ALLERCLEAR D 24 HR Extended Release",
"ALLERCLEAR-D 24 Hour",
"Wal Itin D Non Drowsy 24 Hour Allergy and Congestion",
"Loratadine and Pseudoephedrine Sulfate",
"Loratadine and Pseudoephedrine Sulfate",
"Loratadine and Pseudoephedrine",
"Loratadine and Pseudoephedrine",
"Loratadine and Pseudoephedrine Sulfate",
"Loratadine and Pseudoephedrine",
"Loratadine and Pseudoephedrine",
"Loratadine and Pseudoephedrine",
"Loratadine and Pseudoephedrine Sulfate",
"Loratadine and Pseudoephedrine Sulfate",
"Loratadine and Pseudoephedrine Sulfate",
"Sunmark Loratadine D",
"Equaline Allergy and Congestion Relief",
"Loratadine and Pseudoephedrine Sulfate",
"loratadine D",
"Allergy and Congestion Relief",
"Allergy Relief D",
"Kirkland Signature Allerclear D 12 Hr",
"12 Hour Allergy and Congestion",
"Allergy Relief D",
"Allergy and Congestion Relief",
"Signature Care Allergy and Congestion Relief",
"Careone Allergy and Congestion Relief",
"Allergy Relief D 12",
"Harris Teeter Allergy and Congestion Relief",
"Topcare Allergy and Congestion Relief",
"Sunmark Loratadine D",
"Health Mart Allergy and Congestion",
"Allergy and Congestion Relief",
"Claritin-D 12 Hour",
"Allergy Relief-D 24 Hour 24 Hour",
"Allergy Relief-D 24 Hour",
"Kirkland Signature AllerClear D 12 hr",
"Wal-itin D 24 Hour",
"Allergy Relief-D 24 Hour",
"Claritin-D 24 Hour",
"Allergy Relief-D24 Hour 24 Hour",
"Allergy Relief d 12",
"Wal itin D 12 hour allergy and congestion",
"Good Neighbor Pharmacy Loratadine D",
"CareOne Allergy and congestion relief",
"Loratadine and Pseudoephedrine",
"Loratadine and Pseudoephedrine",
"Alavert Allergy Sinus D-12",
"Signature Care Allergy and Congestion Relief",
"Allergy Relief-D",
"Loratadine and Pseudoephedrine Sulfate",
"Loratadine and Pseudoephedrine Sulfate",
"Loratadine and Pseudoephedrine Sulfate",
"Loratadine and Pseudoephedrine Sulfate",
"Leader Allergy Relief D12",
"Leader Allergy Relief D-24",
"Loratadine and Pseudoephedrine",
"Loratadine and Pseudoephedrine Sulfate",
"Allergy Relief D",
"Loratadine and Pseudoephedrine",
"Health Mart Allergy and Congestion",
"Equaline Allergy and Congestion Relief",
"Good Sense Allergy and Congestion Relief Non Drowsy 24 Hour",
"Claritin-D 24 Hour",
"Smart Sense allergy and congestion relief indoor and outdoor allergies",
"Allergy and Congestion Relief",
"Allergy Relief D 12 Hour",
"Allergy and Congestion Relief",
"Good Sense Allergy and Congestion Relief",
"Good Neighbor Pharmacy Loratadine D",
"Loratadine D 24 Hour",
"Loratadine and Pseudoephedrine",
"Allergy and Congestion Relief",
"Smart Sense Allergy and Congestion Relief D",
"Loratadine D",
"Loratadine and Pseudoephedrine",
"Loratadine D",
"Loratadine and Pseudoephedrine Sulfate",
"Equate Allergy and Congestion Relief",
"Loratadine and Pseudoephedrine",
"Claritin-D 24 Hour",
"Allergy Relief D 12",
"Perrigo Allergy D",
"Chlor-tripolon Nd Srt",
"Liberator",
"Claritin Allergy + Sinus",
"Claritin Allergy + Sinus Extra Strength",
"Alavert Allergy and Congestion D-12 hour",
"Picnic Nasal Decongestant and Antihistamine",
"Diphen",
"Claritin-D 12 Hour",
"Claritin-D 24 Hour",
"Loratadine and Pseudoephedrine",
"Claritin Chewable Grape and Bubblegum",
"Claritin Chewable Grape and Bubblegum",
"Topcare Allergy and Congestion Relief",
"foster and thrive allergy D 12 hour",
"Allergy Congestion Relief",
"Allergy Relief D"
] |
[
"P35367",
"Q12809"
] |
[
"P08684",
"P10635",
"P04798",
"P33261",
"P10632",
"P05177",
"P20813",
"P11712",
"P20815",
"P36537",
"P22309",
"P35503",
"P54855"
] |
[] |
[
"P08183",
"O95342"
] |
DB00456
|
Cefalotin
|
Cefalotin is a cephalosporin antibiotic.
|
solid
|
Used to prevent infection during surgery and to treat many kinds of infections of the blood, bone or joints, respiratory tract, skin, and urinary tract.
|
Cefalotin (INN) or cephalothin (USAN) is a semisynthetic first generation cephalosporin having a broad spectrum of antibiotic activity that is administered parenterally.
|
The bactericidal activity of cefalotin results from the inhibition of cell wall synthesis via affinity for penicillin-binding proteins (PBPs). The PBPs are transpeptidases which are vital in peptidoglycan biosynthesis. Therefore, their inhibition prevents this vital cell wall compenent from being properly synthesized.
| null |
Metabolized to a less active desacetyl metabolite, although 50-75% of the drug is eliminated unchanged in the urine.
|
Rat intravenous LD<sub>50</sub> is 4000 mg/kg.
|
30 minutes
|
65-80%
| null | null | null |
Organic compounds
|
Organoheterocyclic compounds
|
Lactams
|
Beta lactams
|
[
"approved",
"investigational",
"vet_approved"
] |
[
"J01DB",
"J01D",
"J01",
"J"
] |
[
"Enteric bacteria and other eubacteria"
] |
[] |
[] |
3-Acetoxymethyl-7-(2-thienylacetamido)-3-cephem-4-carboxylic acid | 7-(2-Thienylacetamido)cephalosporanic acid | 7-(2'-thienylacetamido)cephalosporanic acid | 7-(Thiophene-2-acetamido)cephalosporin | Cefalothin | Cefalotin | Cefalotina | Céfalotine | Cefalotinum | Cephalothin | Cephalotin | CET | 3.4.16.4 | DD-carboxypeptidase | exp2 | Exported protein 2 | PBP-1A | Putative D-alanyl-D-alanine carboxypeptidase | pbp2b | PBP1 | 3.5.2.6 | ampA | Cephalosporinase | High-affinity sodium-dependent carnitine cotransporter | OCTN2 | Solute carrier family 22 member 5 | Intestinal H(+)/peptide cotransporter | Oligopeptide transporter, small intestine isoform | PEPT1 | Peptide transporter 1 | Kidney H(+)/peptide cotransporter | Oligopeptide transporter, kidney isoform | PEPT2 | Peptide transporter 2 | hOAT1 | hPAHT | hROAT1 | OAT1 | Organic anion transporter 1 | PAH transporter | PAHT | Renal organic anion transporter 1 | hOAT3 | OAT3 | Organic anion/dicarboxylate exchanger | Solute carrier family 22 member 8 | OAT4 | Organic anion transporter 4 | Organic anion:dicarboxylate exchanger OAT4 | hOAT2 | NLT | Novel liver transporter | OAT2 | Organic anion transporter 2
|
[
"Ceporacin",
"Keflin Add-vantage Inj 1gm/vial",
"Keflin Neutral Inj 1gm",
"Keflin Neutral Inj 2gm/vial"
] |
[
"Cefalotina fabra",
"Coaxin",
"Keflin"
] |
[] |
[] |
[] |
[
"P02768"
] |
[
"O76082",
"P46059",
"Q16348",
"Q4U2R8",
"Q8TCC7",
"Q9NSA0",
"Q9Y694"
] |
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