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DB00457	Prazosin	Prazosin is a drug used to treat hypertension. Prazosin is marketed by _Pfizer_ and was initially approved by the FDA in 1988.[L5828] It belongs to the class of drugs known as alpha-1 antagonists. Recently, many studies have evaluated the benefits of this drug in controlling the symptoms of post-traumatic stress disorder (PTSD) and associated nightmares.[A176618, A176621, A176624]	solid	This drug is indicated for the treatment of hypertension (high blood pressure). Prazosin can be given alone or given with other blood pressure-lowering drugs, including diuretics or beta-adrenergic blocking agents [FDA label]. Prazosin does not negatively impact lung function, and therefore may be used to manage hypertension in patients who are asthmatic or patients with chronic obstructive lung disease (COPD)[A176630].	Effects on blood pressure The pharmacodynamic and therapeutic effect of this drug includes is a decrease in blood pressure as well as clinically significant decreases in cardiac output, heart rate, blood flow to the kidney, and glomerular filtration rate. The decrease in blood pressure may occur in both standing and supine positions [FDA label]. Many of the above effects are due to vasodilation of blood vessels caused by prazosin, resulting in decreased peripheral resistance [A176627], [FDA label]. Peripheral resistance refers to the level resistance of the blood vessels to blood that flows through them. As the blood vessels constrict (narrow), the resistance increases and as they dilate (widen), and peripheral resistance decreases, lowering blood pressure [A176747, L5831]. Effects on sleep disturbance related to post-traumatic stress disorder (PTSD) Some studies have suggested that this drug improves sleep in patients suffering from insomnia related to nightmares and post-traumatic stress disorder, caused by hyperarousal [A176621, A176624]. This effect likely occurs through the inhibition of adrenergic stimulation found in states of hyperarousal [A176738].	Alpha-adrenergic receptors are essential for the regulation of blood pressure in humans. Two types of alpha receptors, alpha 1 and alpha 2, both play a role in regulating blood pressure. Alpha-1 receptors are postsynaptic (located after the nerve junction, or space between a nerve fiber and target tissue). In this case, the target tissue is the vascular smooth muscle [L5837]. These receptors, when activated, increase blood pressure [A176648]. Prazosin inhibits the postsynaptic alpha-1 adrenoceptors. This inhibition blocks the vasoconstricting (narrowing) effect of catecholamines (epinephrine and norepinephrine) on the vessels, leading to peripheral blood vessel dilation. Through blood vessel constriction by adrenergic receptor activation, epinephrine and norepinephrine normally act to increase blood pressure [A176654].	After administration of an oral dose, peak plasma concentrations are attained at approximately 3 hours [FDA label]. There is a linear association between the prazosin dose given and plasma concentration at steady state [A176657].	In animals, prazosin hydrochloride is heavily metabolized. This occurs through liver demethylation and conjugation [FDA label]. Some studies in humans or human cells in vitro show similar prazosin metabolism [A176627, A176663].	TDLO, LD50: Oral TDLO (human): 285 μg/kg; Oral TDLO (woman): 10 μg/kg [MSDS]. Oral LD50 (rat): 1950 mg/kg; Intraperitoneal LD50 (rat): 102 mg/kg [MSDS]. Overdose information Accidental ingestion of at least 50 mg of prazosin by a two-year-old child led to severe drowsiness with depressed reflexes. There was no fall in blood pressure, and the child recovered without complication [FDA label]. Use in pregnancy There are no adequate and well-controlled studies determining the safety of prazosin use during pregnancy. It is considered a pregnancy category C drug. Prazosin should be used during pregnancy only in cases where the benefit outweighs the possible risk to the mother and fetus [FDA label]. In specific cases where blood pressure control was emergent during pregnancy, prazosin has been used and no effects on the fetus or neonate were reported [FDA label]. Use in nursing This drug is found excreted in small concentrations in human milk. This drug should be used with caution when used during nursing [FDA label].	The plasma half-life is about 2-3 hours [FDA label].	Highly bound to proteins [FDA label] with 97% binding to albumin and alpha 1-acid glycoprotein [A176657]. Prazosin is thought to be mostly (about 80-90%) bound to albumin [A11794].	This drug is mainly excreted in the bile and the feces [FDA label].	About 0.6 L/kg [A176657].	In patients with congestive heart failure, the clearance of this drug is decreased. Impairment of renal function does not have relevant effects on elimination [A176630].	Organic compounds	Organoheterocyclic compounds	Diazinanes	Piperazines	[ "approved" ]	[ "C02LE", "C02L", "C02", "C", "C02CA", "C02C", "C02", "C" ]	[ "Humans and other mammals" ]	[ { "cost": "1.14", "description": "Minipress 2 mg capsule", "unit": "capsule" }, { "cost": "1.97", "description": "Minipress 5 mg capsule", "unit": "capsule" }, { "cost": "0.15", "description": "Vasoflex tablet", "unit": "tablet" }, { "cost": "0.22", "description": "Apo-Prazo 1 mg Tablet", "unit": "tablet" }, { "cost": "0.22", "description": "Novo-Prazin 1 mg Tablet", "unit": "tablet" }, { "cost": "0.22", "description": "Nu-Prazo 1 mg Tablet", "unit": "tablet" }, { "cost": "0.29", "description": "Vasoflex forte capsule", "unit": "capsule" }, { "cost": "0.29", "description": "Apo-Prazo 2 mg Tablet", "unit": "tablet" }, { "cost": "0.29", "description": "Novo-Prazin 2 mg Tablet", "unit": "tablet" }, { "cost": "0.29", "description": "Nu-Prazo 2 mg Tablet", "unit": "tablet" }, { "cost": "0.38", "description": "Vasoflex hd caplet", "unit": "caplet" }, { "cost": "0.4", "description": "Prazosin 1 mg capsule", "unit": "capsule" }, { "cost": "0.4", "description": "Apo-Prazo 5 mg Tablet", "unit": "tablet" }, { "cost": "0.4", "description": "Novo-Prazin 5 mg Tablet", "unit": "tablet" }, { "cost": "0.4", "description": "Nu-Prazo 5 mg Tablet", "unit": "tablet" }, { "cost": "0.41", "description": "Prazosin HCl 1 mg capsule", "unit": "capsule" }, { "cost": "0.55", "description": "Prazosin 2 mg capsule", "unit": "capsule" }, { "cost": "0.57", "description": "Prazosin HCl 2 mg capsule", "unit": "capsule" }, { "cost": "0.83", "description": "Minipress 1 mg capsule", "unit": "capsule" }, { "cost": "0.94", "description": "Prazosin 5 mg capsule", "unit": "capsule" }, { "cost": "0.98", "description": "Prazosin HCl 5 mg capsule", "unit": "capsule" } ]	[]	1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine \| 2-(4-(2-Furoyl)piperazin-1-yl)-4-amino-6,7-dimethoxyquinazoline \| Prazosin \| Prazosina \| Prazosine \| Prazosinum \| ADRA1C \| Alpha-1A adrenoceptor \| Alpha-1A adrenoreceptor \| Alpha-1C adrenergic receptor \| Alpha-adrenergic receptor 1c \| Alpha-1B adrenoceptor \| Alpha-1B adrenoreceptor \| ADRA1A \| Alpha-1A adrenergic receptor \| Alpha-1D adrenoceptor \| Alpha-1D adrenoreceptor \| Alpha-adrenergic receptor 1a \| Eag homolog \| Eag-related protein 1 \| ERG \| ERG-1 \| ERG1 \| Ether-a-go-go-related gene potassium channel 1 \| Ether-a-go-go-related protein 1 \| H-ERG \| HERG \| hERG-1 \| hERG1 \| Potassium voltage-gated channel subfamily H member 2 \| Voltage-gated potassium channel subunit Kv11.1 \| ADRA2R \| ADRAR \| Alpha-2 adrenergic receptor subtype C10 \| Alpha-2A adrenoceptor \| Alpha-2A adrenoreceptor \| Alpha-2AAR \| ADRA2L1 \| ADRA2RL1 \| Alpha-2 adrenergic receptor subtype C2 \| Alpha-2B adrenoceptor \| Alpha-2B adrenoreceptor \| Alpha-2BAR \| ADRA1C \| Alpha-1A adrenoceptor \| Alpha-1A adrenoreceptor \| Alpha-1C adrenergic receptor \| Alpha-adrenergic receptor 1c \| Alpha-1B adrenoceptor \| Alpha-1B adrenoreceptor \| ADRA1A \| Alpha-1A adrenergic receptor \| Alpha-1D adrenoceptor \| Alpha-1D adrenoreceptor \| Alpha-adrenergic receptor 1a \| AGP 1 \| AGP1 \| OMD 1 \| Orosomucoid-1 \| hOCT1 \| OCT1 \| Organic cation transporter 1 \| EMT \| EMTH \| Extraneuronal monoamine transporter \| OCT3 \| Organic cation transporter 3 \| ATP-binding cassette sub-family B member 1 \| MDR1 \| Multidrug resistance protein 1 \| P-glycoprotein 1 \| PGY1 \| Phospholipid transporter ABCB1 \| 7.6.2.2 \| ABCP \| ATP-binding cassette sub-family G member 2 \| BCRP \| BCRP1 \| Breast cancer resistance protein \| CDw338 \| Mitoxantrone resistance-associated protein \| MXR \| Placenta-specific ATP-binding cassette transporter \| Urate exporter	[ "Alti-prazosin-tab 1mg", "Alti-prazosin-tab 2mg", "Alti-prazosin-tab 5mg", "Apo-prazo Tab 1mg", "Apo-prazo Tab 2mg", "Apo-prazo Tab 5mg", "Minipress", "Minipress", "Minipress", "Minipress", "Minipress", "Minipress", "Minipress", "Minipress", "Minizide", "Minizide", "Minizide", "Nu-prazo Tab 1mg", "Nu-prazo Tab 2mg", "Nu-prazo Tab 5mg", "Prazosin", "Prazosin", "Prazosin", "Prazosin", "Prazosin", "Prazosin", "Prazosin", "Prazosin HCL", "Prazosin HCL", "Prazosin HCL", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin hydrochloride", "Prazosin hydrochloride", "Prazosin hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin Hydrochloride", "Prazosin-1 Tab 1mg", "Prazosin-2 Tab 2mg", "Prazosin-5 Tab", "Rho-prazosin - Tab 1mg", "Rho-prazosin - Tab 5mg", "Rho-prazosin-tab 2mg", "Teva-prazosin", "Teva-prazosin", "Teva-prazosin" ]	[ "Hypovase", "Minipress Xl", "Pressin", "Vasoflex" ]	[ "Minizide", "Minizide", "Minizide" ]	[ "P35348", "P35368", "P25100", "Q12809", "P08913", "P18089", "P35348", "P35368", "P25100" ]	[]	[ "P02763" ]	[ "O15245", "O75751", "P08183", "Q9UNQ0" ]
DB00458	Imipramine	Imipramine, the prototypical tricyclic antidepressant (TCA), is a dibenzazepine-derivative TCA. TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, imipramine does not affect mood or arousal, but may cause sedation. In depressed individuals, imipramine exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. Tertiary amine TCAs, such as imipramine and amitriptyline, are more potent inhibitors of serotonin reuptake than secondary amine TCAs, such as nortriptyline and desipramine. TCAs also block histamine H<sub>1</sub> receptors, α<sub>1</sub>-adrenergic receptors and muscarinic receptors, which accounts for their sedative, hypotensive and anticholinergic effects (e.g. blurred vision, dry mouth, constipation, urinary retention), respectively [A6584]. Imipramine has less sedative and anticholinergic effects than the tertiary amine TCAs, amitriptyline and clomipramine. Imipramine may be used to treat depression and nocturnal enuresis in children [FDA Label]. Unlabeled indications include chronic and neuropathic pain (including diabetic neuropathy), panic disorder, attention-deficit/hyperactivity disorder (ADHD), and post-traumatic stress disorder (PTSD) [L1349,L1348,A31900,L1351,L1352,L1353,A31904].	solid	For the relief of symptoms of depression and as temporary adjunctive therapy in reducing enuresis in children aged 6 years and older [FDA Label]. May also be used off-label to manage panic disorders with or without agoraphobia, as a second line agent for ADHD in children and adolescents, to manage bulimia nervosa, for short-term management of acute depressive episodes in bipolar disorder and schizophrenia, for the treatment of acute stress disorder and posttraumatic stress disorder, and for symptomatic treatment of postherpetic neuralgia and painful diabetic neuropathy [L1349,L1348,A31900,L1351,L1352,L1353,A31904].	Imipramine is a tricyclic antidepressant with general pharmacological properties similar to those of structurally related tricyclic antidepressant drugs such as amitriptyline and doxepin. While it acts to block both, imipramine displays a much higher affinity for the serotonin reuptake transporter than for the norepinephrine reuptake transporter [A6584]. Imipramine produces effects similar to other monoamine targeting antidepressants, increasing serotonin- and norepinephrine-based neurotransmission. This modulation of neurotransmission produces a complex range of changes in brain structure and function along with an improvement in depressive symptoms. The changes include increases in hippocampal neurogenesis and reduced downregulation of this neurogenesis in response to stress [A31931]. These implicate brain derived neurotrophic factor signalling as a necessary contributor to antidepressant effect although the link to the direct increase in monoamine neurotransmission is unclear. Serotonin reuptake targeting agents may also produce a down-regulation in β-adrenergic receptors in the brain [A31938].	Imipramine works by inhibiting the neuronal reuptake of the neurotransmitters norepinephrine and serotonin [A6584,T116]. It binds the sodium-dependent serotonin transporter and sodium-dependent norepinephrine transporter reducing the reuptake of norepinephrine and serotonin by neurons. Depression has been linked to a lack of stimulation of the post-synaptic neuron by norepinephrine and serotonin [A31933]. Slowing the reuptake of these neurotransmitters increases their concentration in the synaptic cleft, producing knock-on effects in protein kinase signalling which is thought to contribute to changes in neurotransmission and brain physiology which relieves symptoms of depression [A31939].	Rapidly and well absorbed (>95%) after oral administration [A31907]. The primary site of absorption is the small intestine as the basic amine groups are ionized in the acidic environment of the stomach, preventing movement across tissues. Bioavailability ranges from 29-77% due to high inter-individual variability. Peak plasma concentration is usually attained 2-6 hours following oral administration. Absorption is unaffected by food.	Imipramine is nearly exclusively metabolized by the liver [A31907]. Imipramine is converted to desipramine by CYP1A2, CYP3A4, CYP2C19. Both imipramine and desipramine are hydroxylated by CYP2D6 [A31915]. Desipramine is an active metabolite. Minor metabolic pathways include dealkylation to form an imidodibenzyl product as well as demethylation of desipramine to didemethylimipramine and subsequent hydroxylation [A31907]. Less than 5% of orally administered imipramine is excreted unchanged.	The anticholinergic actvity of imipramine can produce dry mucous membranes, blurred vision, increased intraocular pressure, hyperthermia, constipation, adynamic ileus, urinary retention, delayed micturition, and dilation of the urinary tract [L1360]. Central nervous system and neuromuscular effects include drowsiness, lethargy, fatigue, agitation, excitement, nightmares, restlessness, insomnia, confusion, disturbed concentration, disorientation, delusions, and hallucinations. Effects on the GI tract include anorexia, nausea and vomiting, diarrhea, abdominal cramps, increases in pancreatic enzymes, epigastric distress, stomatitis, peculiar taste, and black tongue. Rarely agranulocytosis, thrombocytopenia, eosinophilia, leukopenia, and purpura have occured. Infants whose mothers were receiving tricyclic antidepressants prior to delivery have experienced cardiac problems, irritability, respiratory distress, muscle spasms, seizures, and urinary retention. Serotonin syndrome can occur when used in conjunction with other pro-serotonergic drugs. ### LD<sub>50</sub/> Values Rat - Oral 250 mg/kg - Intraperitoneal 79mg/kg - Subcutaneous 250 mg/kg - Intravenous 15.9 mg/kg Mouse - Oral 188 mg/kg - Intraperitoneal 51.6 mg/kg - Subcutaneous 195 μg/kg - Intravenous 21 mg/kg Human range of toxicity is considered to include single dosages greater than 5 mg/kg.	Imipramine has a mean half life of 12 h. Its active metabolite, desipramine has a mean half life of 22.5 h [A31907].	Imipramine is 60-96% bound to plasma proteins in circulation [A31907]. It is known to bind albumin, α1-acid glycoprotein, and lipoproteins.	Imipramine is primarily excreted in the urine with less than 5% present as the parent compound [A31907]	Imipramine has a high apparent volume of distribution of 10-20 L/kg [A31907]. The drug is known to accumulate in the brain at concentrations 30-40 times that in systemic circulation.	Imipramine has a mean clearance of 1 L/h/kg. Its active metabolite, desipramine has a mean clearance of 1.8 L/h/kg [A31907].	Organic compounds	Organoheterocyclic compounds	Benzazepines	Dibenzazepines	[ "approved" ]	[ "N06AA", "N06A", "N06", "N" ]	[ "Humans and other mammals" ]	[ { "cost": "1.92", "description": "Trimipramine 25 mg capsule", "unit": "capsule" }, { "cost": "2.21", "description": "Cenestin 0.3 mg tablet", "unit": "tablet" }, { "cost": "2.21", "description": "Cenestin 0.45 mg tablet", "unit": "tablet" }, { "cost": "2.21", "description": "Cenestin 0.625 mg tablet", "unit": "tablet" }, { "cost": "2.21", "description": "Cenestin 0.9 mg tablet", "unit": "tablet" }, { "cost": "2.21", "description": "Cenestin 1.25 mg tablet", "unit": "tablet" }, { "cost": "2.49", "description": "Surmontil 25 mg capsule", "unit": "capsule" }, { "cost": "3.14", "description": "Trimipramine 50 mg capsule", "unit": "capsule" }, { "cost": "3.27", "description": "Trimipramine Maleate 50 mg capsule", "unit": "capsule" }, { "cost": "4.07", "description": "Surmontil 50 mg capsule", "unit": "capsule" }, { "cost": "4.73", "description": "Tofranil 10 mg tablet", "unit": "tablet" }, { "cost": "4.97", "description": "Tofranil 25 mg tablet", "unit": "tablet" }, { "cost": "5.92", "description": "Surmontil 100 mg capsule", "unit": "capsule" }, { "cost": "6.64", "description": "Tofranil 50 mg tablet", "unit": "tablet" }, { "cost": "15.17", "description": "Imipramine pamoate 100 mg capsule", "unit": "capsule" }, { "cost": "15.17", "description": "Imipramine pamoate 125 mg capsule", "unit": "capsule" }, { "cost": "15.17", "description": "Imipramine pamoate 150 mg capsule", "unit": "capsule" }, { "cost": "16.35", "description": "Imipramine pamoate 75 mg capsule", "unit": "capsule" }, { "cost": "18.68", "description": "Tofranil-pm 125 mg capsule", "unit": "capsule" }, { "cost": "18.86", "description": "Tofranil-pm 150 mg capsule", "unit": "capsule" }, { "cost": "18.86", "description": "Tofranil-pm 75 mg capsule", "unit": "capsule" }, { "cost": "19.23", "description": "Tofranil-pm 100 mg capsule", "unit": "capsule" }, { "cost": "51.0", "description": "Trimipramine maleate powder", "unit": "g" }, { "cost": "185.09", "description": "Tofranil 30 50 mg tablet Bottle", "unit": "bottle" }, { "cost": "588.33", "description": "Tofranil-PM 30 125 mg capsule Bottle", "unit": "bottle" }, { "cost": "588.33", "description": "Tofranil-PM 30 150 mg capsule Bottle", "unit": "bottle" }, { "cost": "588.33", "description": "Tofranil-PM 30 75 mg capsule Bottle", "unit": "bottle" }, { "cost": "0.14", "description": "Apo-Imipramine 10 mg Tablet", "unit": "tablet" }, { "cost": "0.23", "description": "Apo-Trimip 12.5 mg Tablet", "unit": "tablet" }, { "cost": "0.25", "description": "Apo-Imipramine 25 mg Tablet", "unit": "tablet" }, { "cost": "0.29", "description": "Apo-Trimip 25 mg Tablet", "unit": "tablet" }, { "cost": "0.35", "description": "Imipramine hcl 25 mg tablet", "unit": "tablet" }, { "cost": "0.4", "description": "Apo-Imipramine 50 mg Tablet", "unit": "tablet" }, { "cost": "0.44", "description": "Imipramine hcl 50 mg tablet", "unit": "tablet" }, { "cost": "0.46", "description": "Imipramine hcl 10 mg tablet", "unit": "tablet" }, { "cost": "0.57", "description": "Tofranil 50 mg Tablet", "unit": "tablet" }, { "cost": "0.57", "description": "Apo-Trimip 50 mg Tablet", "unit": "tablet" }, { "cost": "0.58", "description": "Apo-Imipramine 75 mg Tablet", "unit": "tablet" }, { "cost": "0.77", "description": "Imipramine hcl powder", "unit": "g" }, { "cost": "0.77", "description": "Apo-Trimip 75 mg Capsule", "unit": "capsule" }, { "cost": "0.97", "description": "Apo-Trimip 100 mg Tablet", "unit": "tablet" } ]	[]	10,11-dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine \| 5-[3-(dimethylamino)propyl]-10,11-dihydro-5H-dibenz[b,f]azepine \| Imipramin \| Imipramina \| Imipramine \| Imipraminum \| Imizine \| N-(gamma-Dimethylaminopropyl)iminodibenzyl \| N-(γ-dimethylaminopropyl)iminodibenzyl \| NAT1 \| NET \| NET1 \| Norepinephrine transporter \| SLC6A5 \| Solute carrier family 6 member 2 \| 5HT transporter \| 5HTT \| HTT \| SERT \| Solute carrier family 6 member 4 \| 5-HT-2 \| 5-HT-2A \| HTR2 \| Serotonin receptor 2A \| H1-R \| H1R \| HH1R \| ADRA1C \| Alpha-1A adrenoceptor \| Alpha-1A adrenoreceptor \| Alpha-1C adrenergic receptor \| Alpha-adrenergic receptor 1c \| ADRA1A \| Alpha-1A adrenergic receptor \| Alpha-1D adrenoceptor \| Alpha-1D adrenoreceptor \| Alpha-adrenergic receptor 1a \| KIAA1044 \| Potassium voltage-gated channel subfamily D member 2 \| Voltage-gated potassium channel subunit Kv4.2 \| Potassium voltage-gated channel subfamily D member 3 \| Voltage-gated potassium channel subunit Kv4.3 \| 5-HT-1C \| 5-HT-2C \| 5-HT1C \| 5-HT2C \| 5-HTR2C \| 5-hydroxytryptamine receptor 1C \| HTR1C \| Serotonin receptor 2C \| Alpha-1B adrenoceptor \| Alpha-1B adrenoreceptor \| 5-HT-7 \| 5-HT-X \| 5-HT7 \| Serotonin receptor 7 \| Dopamine D1 receptor \| D(5) dopamine receptor \| D1beta dopamine receptor \| Dopamine D5 receptor \| DRD1B \| DRD1L2 \| Dopamine D2 receptor \| Eag homolog \| Eag-related protein 1 \| ERG \| ERG-1 \| ERG1 \| Ether-a-go-go-related gene potassium channel 1 \| Ether-a-go-go-related protein 1 \| H-ERG \| HERG \| hERG-1 \| hERG1 \| Potassium voltage-gated channel subfamily H member 2 \| Voltage-gated potassium channel subunit Kv11.1 \| DA transporter \| DAT \| DAT1 \| Solute carrier family 6 member 3 \| 5-HT-1A \| 5-HT1A \| ADRB2RL1 \| ADRBRL1 \| G-21 \| Serotonin receptor 1A \| 5-HT-6 \| 5-HT6 \| Serotonin receptor 6 \| EAG \| EAG channel 1 \| EAG1 \| Ether-a-go-go potassium channel 1 \| h-eag \| hEAG1 \| Potassium voltage-gated channel subfamily H member 1 \| Voltage-gated potassium channel subunit Kv10.1 \| AGP 2 \| AGP2 \| OMD 2 \| Orosomucoid-2 \| (R)-limonene 6-monooxygenase \| (S)-limonene 6-monooxygenase \| (S)-limonene 7-monooxygenase \| 1.14.14.1 \| CYPIIC17 \| CYPIIC19 \| Cytochrome P450-11A \| Cytochrome P450-254C \| Fenbendazole monooxygenase (4'-hydroxylating) \| Mephenytoin 4-hydroxylase \| 1.14.14.- \| Cholesterol 25-hydroxylase \| CYP2DL1 \| CYPIID6 \| Cytochrome P450-DB1 \| Debrisoquine 4-hydroxylase \| 1.14.14.1 \| Cholesterol 25-hydroxylase \| CYPIA2 \| Cytochrome P(3)450 \| Cytochrome P450 4 \| Cytochrome P450-P3 \| Hydroperoxy icosatetraenoate dehydratase \| 1,4-cineole 2-exo-monooxygenase \| 1,8-cineole 2-exo-monooxygenase \| 1.14.14.1 \| Albendazole monooxygenase (sulfoxide-forming) \| Albendazole sulfoxidase \| Cholesterol 25-hydroxylase \| CYP3A3 \| CYPIIIA3 \| CYPIIIA4 \| Cytochrome P450 3A3 \| Cytochrome P450 HLp \| Cytochrome P450 NF-25 \| Cytochrome P450-PCN1 \| Nifedipine oxidase \| Quinine 3-monooxygenase \| 1.14.14.1 \| CYPIIIA7 \| Cytochrome P450-HFLA \| P450HLp2 \| 1,4-cineole 2-exo-monooxygenase \| 1.14.13.- \| CYPIIB6 \| Cytochrome P450 IIB1 \| 1.14.14.1 \| CYPIIC18 \| Cytochrome P450-6b/29c \| 1.14.14.1 \| 4-nitrophenol 2-hydroxylase \| CYP2E \| CYPIIE1 \| Cytochrome P450-J \| AGP 1 \| AGP1 \| OMD 1 \| Orosomucoid-1 \| ATP-binding cassette sub-family B member 1 \| MDR1 \| Multidrug resistance protein 1 \| P-glycoprotein 1 \| PGY1 \| Phospholipid transporter ABCB1 \| hOCT2 \| OCT2 \| Organic cation transporter 2 \| EMT \| EMTH \| Extraneuronal monoamine transporter \| OCT3 \| Organic cation transporter 3 \| Ergothioneine transporter \| ET transporter \| ETT \| ETTh \| OCTN1 \| Organic cation/carnitine transporter 1 \| UT2H	[ "Apo-imipramine", "Apo-imipramine", "Apo-imipramine", "Apo-imipramine", "Imipramine", "Imipramine", "Imipramine", "Imipramine", "Imipramine 10tab", "Imipramine 25tab", "Imipramine 50 Tab 50mg", "Imipramine Hydrochloride", "Imipramine Hydrochloride", "Imipramine Hydrochloride", "Imipramine Hydrochloride", "Imipramine Hydrochloride", "Imipramine Hydrochloride", "Imipramine Hydrochloride", "Imipramine Hydrochloride", "Imipramine Hydrochloride", "Imipramine Hydrochloride", "Imipramine Hydrochloride", "Imipramine Hydrochloride", "Imipramine Hydrochloride", "Imipramine Hydrochloride", "Imipramine Hydrochloride", "Imipramine Hydrochloride", "Imipramine Hydrochloride", "Imipramine Hydrochloride", "Imipramine Hydrochloride", "Imipramine Hydrochloride", "Imipramine Hydrochloride", "Imipramine Hydrochloride", "Imipramine Hydrochloride", "Imipramine Hydrochloride", "Imipramine Hydrochloride", "Imipramine Hydrochloride", "Imipramine Hydrochloride", "Imipramine Hydrochloride", "Imipramine Hydrochloride", "Imipramine Hydrochloride", "Imipramine Hydrochloride", "Imipramine Hydrochloride", "Imipramine Hydrochloride", "Imipramine Hydrochloride", "Imipramine Hydrochloride", "Imipramine Hydrochloride", "Imipramine Hydrochloride", "Imipramine Hydrochloride", "Imipramine Hydrochloride", "Imipramine Hydrochloride", "Imipramine Hydrochloride", "Imipramine Hydrochloride", "Imipramine Hydrochloride", "Imipramine Hydrochloride", "Imipramine Hydrochloride", "Imipramine Hydrochloride", "Imipramine Hydrochloride", "Imipramine Hydrochloride", "Imipramine Hydrochloride", "Imipramine Hydrochloride", "Imipramine Hydrochloride", "Imipramine Hydrochloride", "Imipramine Hydrochloride", "Imipramine Hydrochloride", "Imipramine Hydrochloride", "Imipramine Hydrochloride", "Imipramine Hydrochloride", "Imipramine Hydrochloride", "Imipramine Hydrochloride", "Imipramine Hydrochloride", "Imipramine Hydrochloride", "Imipramine Hydrochloride", "Imipramine Hydrochloride", "Imipramine Hydrochloride", "Imipramine Hydrochloride", "Imipramine Hydrochloride", "Imipramine Hydrochloride", "Imipramine Hydrochloride", "Imipramine Hydrochloride", "Imipramine Hydrochloride", "Imipramine Hydrochloride", "Imipramine Hydrochloride", "Imipramine Hydrochloride", "Imipramine Hydrochloride", "Imipramine Hydrochloride", "Imipramine hydrochloride", "Imipramine Hydrochloride", "Imipramine Hydrochloride", "Imipramine Hydrochloride", "Imipramine Hydrochloride", "Imipramine Hydrochloride Tablets 25mg", "Imipramine Hydrochloride Tablets 50mg", "Imipramine Pamoate", "Imipramine Pamoate", "Imipramine Pamoate", "Imipramine Pamoate", "Imipramine Pamoate", "Imipramine Pamoate", "Imipramine Pamoate", "Imipramine Pamoate", "Imipramine Pamoate", "Imipramine Pamoate", "Imipramine Pamoate", "Imipramine Pamoate", "Imipramine Pamoate", "Imipramine Pamoate", "Imipramine Pamoate", "Imipramine Pamoate", "Imipramine Pamoate", "Imipramine Pamoate", "Imipramine Tab 25mg", "Impril", "Impril", "Impril", "Impril", "Jamp Imipramine", "Jamp Imipramine", "Jamp Imipramine", "Jamp Imipramine", "Novo-pramine Tab 10mg", "Novo-pramine Tab 25mg", "Novo-pramine Tab 50mg", "PMS Imipramine Tab 10mg", "PMS Imipramine Tab 25mg", "PMS Imipramine Tab 50mg", "Tofranil", "Tofranil", "Tofranil", "Tofranil", "Tofranil", "Tofranil 10mg", "Tofranil 25mg", "Tofranil 50mg", "Tofranil 75mg", "Tofranil-PM", "Tofranil-PM", "Tofranil-PM", "Tofranil-PM" ]	[ "Antidep", "Antideprin", "Depsonil", "Depsonil-PM", "Elamin", "Fronil", "Imidol", "Imipramin Dak", "Imiprex", "Irmin", "Melipramine", "Pramin" ]	[]	[ "P23975", "P31645", "P28223", "P35367", "P35348", "P25100", "P11229", "P08172", "P20309", "P08173", "P08912", "Q9NZV8", "Q9UK17", "P28335", "P35368", "P34969", "P21728", "P21918", "P14416", "Q12809", "Q01959", "P08908", "P50406", "O95259", "P19652" ]	[ "P33261", "P10635", "P05177", "P08684", "P24462", "P20813", "P33260", "P05181" ]	[ "P02763", "P02768" ]	[ "P08183", "O15244", "O75751", "Q9H015" ]
DB01151	Desipramine	Desipramine hydrochloride is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, desipramine does not affect mood or arousal, but may cause sedation. In depressed individuals, desipramine exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. Secondary amine TCAs, such as desipramine and nortriptyline, are more potent inhibitors of norepinephrine reuptake than tertiary amine TCAs, such as amitriptyline and doxepine. TCAs also down-regulate cerebral cortical β-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use. The antidepressant effects of TCAs are thought to be due to an overall increase in serotonergic neurotransmission. TCAs also block histamine-H<sub>1</sub> receptors, α<sub>1</sub>-adrenergic receptors and muscarinic receptors, which accounts for their sedative, hypotensive and anticholinergic effects (e.g. blurred vision, dry mouth, constipation, urinary retention), respectively. See toxicity section below for a complete listing of side effects. Desipramine exerts less anticholinergic and sedative side effects compared to tertiary amine TCAs, such as amitriptyline and clomipramine. Desipramine may be used to treat depression, neuropathic pain (unlabeled use), agitation and insomnia (unlabeled use) and attention-deficit hyperactivity disorder (unlabeled use).	solid	For relief of symptoms in various depressive syndromes, especially endogenous depression. It has also been used to manage chronic peripheral neuropathic pain, as a second line agent for the management of anxiety disorders (e.g. panic disorder, generalized anxiety disorder), and as a second or third line agent in the ADHD management.	Desipramine, a secondary amine tricyclic antidepressant, is structurally related to both the skeletal muscle relaxant cyclobenzaprine and the thioxanthene antipsychotics such as thiothixene. It is the active metabolite of imipramine, a tertiary amine TCA. The acute effects of desipramine include inhibition of noradrenaline re-uptake at noradrenergic nerve endings and inhibition of serotonin (5-hydroxy tryptamine, 5HT) re-uptake at the serotoninergic nerve endings in the central nervous system. Desipramine exhibits greater noradrenergic re-uptake inhibition compared to the tertiary amine TCA imipramine. In addition to inhibiting neurotransmitter re-uptake, desipramine down-regulates beta-adrenergic receptors in the cerebral cortex and sensitizes serotonergic receptors with chronic use. The overall effect is increased serotonergic transmission. Antidepressant effects are typically observed 2 - 4 weeks following the onset of therapy though some patients may require up to 8 weeks of therapy prior to symptom improvement. Patients experiencing more severe depressive episodes may respond quicker than those with mild depressive symptoms.	Desipramine is a tricyclic antidepressant (TCA) that selectively blocks reuptake of norepinephrine (noradrenaline) from the neuronal synapse. It also inhibits serotonin reuptake, but to a lesser extent compared to tertiary amine TCAs such as imipramine. Inhibition of neurotransmitter reuptake increases stimulation of the post-synaptic neuron. Chronic use of desipramine also leads to down-regulation of beta-adrenergic receptors in the cerebral cortex and sensitization of serotonergic receptors. An overall increase in serotonergic transmission likely confers desipramine its antidepressant effects. Desipramine also possesses minor anticholinergic activity, through its affinity for muscarinic receptors. TCAs are believed to act by restoring normal levels of neurotransmitters via synaptic reuptake inhibition and by increasing serotonergic neurotransmission via serotonergic receptor sensitization in the central nervous system.	Desipramine hydrochloride is rapidly and almost completely absorbed from the gastrointestinal tract. It undergoes extensive first-pass metabolism. Peak plasma concentrations are attained 4 - 6 hours following oral administration.	Desipramine is extensively metabolized in the liver by CYP2D6 (major) and CYP1A2 (minor) to 2-hydroxydesipramine, an active metabolite. 2-hydroxydesipramine is thought to retain some amine reuptake inhibition and may possess cardiac depressant activity. The 2-hydroxylation metabolic pathway of desipramine is under genetic control.	Male mice: LD50 = 290 mg/kg, female rats: LD50 = 320 mg/kg. Antagonism of the histamine H<sub>1</sub> and α<sub>1</sub> receptors can lead to sedation and hypotension. Antimuscarinic activity confers anticholinergic side effects such as blurred vision, dry mouth, constipation and urine retention may occur. Cardiotoxicity may occur with high doses of desipramine. Cardiovascular side effects in postural hypotension, tachycardia, hypertension, ECG changes and congestive heart failure. Psychotoxic effects include impaired memory and delirium. Induction of hypomanic or manic episodes may occur in patients with a history of bipolar disorder. Withdrawal symptoms include GI disturbances (e.g. nausea, vomiting, abdominal pain, diarrhea), anxiety, insomnia, nervousness, headache and malaise.	7-60+ hours; 70% eliminated renally	73-92% bound to plasma proteins	Desipramine is metabolized in the liver, and approximately 70% is excreted in the urine.	null	null	Organic compounds	Organoheterocyclic compounds	Benzazepines	Dibenzazepines	[ "approved", "investigational" ]	[ "N06AA", "N06A", "N06", "N" ]	[ "Humans and other mammals" ]	[ { "cost": "1.11", "description": "Norpramin 10 mg tablet", "unit": "tablet" }, { "cost": "1.15", "description": "Desipramine 75 mg tablet", "unit": "tablet" }, { "cost": "1.33", "description": "Norpramin 25 mg tablet", "unit": "tablet" }, { "cost": "1.5", "description": "Desipramine 100 mg tablet", "unit": "tablet" }, { "cost": "1.64", "description": "Desipramine HCl 50 mg tablet", "unit": "tablet" }, { "cost": "2.18", "description": "Desipramine 150 mg tablet", "unit": "tablet" }, { "cost": "2.51", "description": "Norpramin 50 mg tablet", "unit": "tablet" }, { "cost": "2.63", "description": "Desipramine HCl 75 mg tablet", "unit": "tablet" }, { "cost": "2.81", "description": "Desipramine HCl 100 mg tablet", "unit": "tablet" }, { "cost": "3.19", "description": "Norpramin 75 mg tablet", "unit": "tablet" }, { "cost": "4.2", "description": "Norpramin 100 mg tablet", "unit": "tablet" }, { "cost": "4.67", "description": "Desipramine HCl 150 mg tablet", "unit": "tablet" }, { "cost": "6.08", "description": "Norpramin 150 mg tablet", "unit": "tablet" }, { "cost": "14.4", "description": "Desipramine hcl powder", "unit": "g" }, { "cost": "0.4", "description": "Desipramine 10 mg tablet", "unit": "tablet" }, { "cost": "0.4", "description": "Apo-Desipramine 10 mg Tablet", "unit": "tablet" }, { "cost": "0.4", "description": "Apo-Desipramine 25 mg Tablet", "unit": "tablet" }, { "cost": "0.49", "description": "Desipramine 25 mg tablet", "unit": "tablet" }, { "cost": "0.7", "description": "Apo-Desipramine 50 mg Tablet", "unit": "tablet" }, { "cost": "0.83", "description": "Desipramine HCl 25 mg tablet", "unit": "tablet" }, { "cost": "0.87", "description": "Desipramine HCl 10 mg tablet", "unit": "tablet" }, { "cost": "0.92", "description": "Desipramine 50 mg tablet", "unit": "tablet" }, { "cost": "0.93", "description": "Apo-Desipramine 75 mg Tablet", "unit": "tablet" } ]	[]	5-(gamma-methylaminopropyl)iminodibenzyl \| 5-(γ-methylaminopropyl)iminodibenzyl \| Déméthylimipramine \| Desipramin \| Desipramina \| Desipramine \| Désipramine \| Desipraminum \| Desmethylimipramine \| DMI \| Monodemethylimipramine \| N-(3-methylaminopropyl)iminobibenzyl \| Norimipramine \| NAT1 \| NET \| NET1 \| Norepinephrine transporter \| SLC6A5 \| Solute carrier family 6 member 2 \| 5HT transporter \| 5HTT \| HTT \| SERT \| Solute carrier family 6 member 4 \| 5-HT-2 \| 5-HT-2A \| HTR2 \| Serotonin receptor 2A \| ADRB2R \| B2AR \| Beta-2 adrenoceptor \| Beta-2 adrenoreceptor \| ADRB1R \| B1AR \| Beta-1 adrenoceptor \| Beta-1 adrenoreceptor \| 3.1.4.12 \| 3.1.4.3 \| Acid sphingomyelinase \| ASM \| aSMase \| H1-R \| H1R \| HH1R \| ADRA1C \| Alpha-1A adrenoceptor \| Alpha-1A adrenoreceptor \| Alpha-1C adrenergic receptor \| Alpha-adrenergic receptor 1c \| Alpha-1B adrenoceptor \| Alpha-1B adrenoreceptor \| ADRA1A \| Alpha-1A adrenergic receptor \| Alpha-1D adrenoceptor \| Alpha-1D adrenoreceptor \| Alpha-adrenergic receptor 1a \| 5-HT-1A \| 5-HT1A \| ADRB2RL1 \| ADRBRL1 \| G-21 \| Serotonin receptor 1A \| 5-HT-1C \| 5-HT-2C \| 5-HT1C \| 5-HT2C \| 5-HTR2C \| 5-hydroxytryptamine receptor 1C \| HTR1C \| Serotonin receptor 2C \| Dopamine D2 receptor \| ADRA2R \| ADRAR \| Alpha-2 adrenergic receptor subtype C10 \| Alpha-2A adrenoceptor \| Alpha-2A adrenoreceptor \| Alpha-2AAR \| ADRA2L1 \| ADRA2RL1 \| Alpha-2 adrenergic receptor subtype C2 \| Alpha-2B adrenoceptor \| Alpha-2B adrenoreceptor \| Alpha-2BAR \| ADRA2L2 \| ADRA2RL2 \| Alpha-2 adrenergic receptor subtype C4 \| Alpha-2C adrenoceptor \| Alpha-2C adrenoreceptor \| Alpha-2CAR \| 1.14.14.- \| Cholesterol 25-hydroxylase \| CYP2DL1 \| CYPIID6 \| Cytochrome P450-DB1 \| Debrisoquine 4-hydroxylase \| 1.14.14.1 \| Cholesterol 25-hydroxylase \| CYPIA2 \| Cytochrome P(3)450 \| Cytochrome P450 4 \| Cytochrome P450-P3 \| Hydroperoxy icosatetraenoate dehydratase \| 1,4-cineole 2-exo-monooxygenase \| 1,8-cineole 2-exo-monooxygenase \| 1.14.14.1 \| Albendazole monooxygenase (sulfoxide-forming) \| Albendazole sulfoxidase \| Cholesterol 25-hydroxylase \| CYP3A3 \| CYPIIIA3 \| CYPIIIA4 \| Cytochrome P450 3A3 \| Cytochrome P450 HLp \| Cytochrome P450 NF-25 \| Cytochrome P450-PCN1 \| Nifedipine oxidase \| Quinine 3-monooxygenase \| 1,4-cineole 2-exo-monooxygenase \| 1.14.13.- \| CYPIIB6 \| Cytochrome P450 IIB1 \| 1.14.14.1 \| 4-nitrophenol 2-hydroxylase \| CYP2E \| CYPIIE1 \| Cytochrome P450-J \| AGP 1 \| AGP1 \| OMD 1 \| Orosomucoid-1 \| ATP-binding cassette sub-family B member 1 \| MDR1 \| Multidrug resistance protein 1 \| P-glycoprotein 1 \| PGY1 \| Phospholipid transporter ABCB1 \| hOCT1 \| OCT1 \| Organic cation transporter 1 \| EMT \| EMTH \| Extraneuronal monoamine transporter \| OCT3 \| Organic cation transporter 3 \| hOCT2 \| OCT2 \| Organic cation transporter 2 \| High-affinity sodium-dependent carnitine cotransporter \| OCTN2 \| Solute carrier family 22 member 5 \| Ergothioneine transporter \| ET transporter \| ETT \| ETTh \| OCTN1 \| Organic cation/carnitine transporter 1 \| UT2H	[ "Desipramine", "Desipramine", "Desipramine", "Desipramine", "Desipramine", "Desipramine", "Desipramine", "Desipramine", "Desipramine", "Desipramine", "Desipramine", "Desipramine HCL", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine Hydrochloride", "Desipramine-10 - Tab 10mg", "Desipramine-25 - Tab 25mg", "Desipramine-50 - Tab 50mg", "Desipramine-75 - Tab 75mg", "Dom-desipramine Tablets - 25mg", "Dom-desipramine Tablets - 50mg", "Norpramin", "Norpramin", "Norpramin", "Norpramin", "Norpramin", "Norpramin", "Norpramin", "Norpramin", "Norpramin", "Norpramin", "Norpramin", "Norpramin", "Norpramin 100mg Tab", "Norpramin 10mg Tab", "Norpramin 25mg Tab", "Norpramin 50mg Tab", "Norpramin 75mg Tab", "Norpramin Tab 25mg", "Norpramin Tab 50mg", "Norpramin Tab 75mg", "Novo-desipramine Fc - 50mg Tab", "Novo-desipramine Sc - Tab 10mg", "Novo-desipramine Sc - Tab 25mg", "Novo-desipramine Sc -tab 75mg", "Penta-desipramine Tablets", "Penta-desipramine Tablets", "Penta-desipramine Tablets", "Penta-desipramine Tablets", "Pertofrane 25mg", "Pertofrane Tab 50mg", "PHL-desipramine", "PHL-desipramine", "PHL-desipramine", "PHL-desipramine", "PHL-desipramine", "PMS Desipramine Hydro Tab 10mg", "PMS Desipramine Hydro Tab 25mg", "PMS Desipramine Hydro Tab 50mg", "PMS Desipramine Hydro Tab 75mg", "PMS-desipramine - Tab 100mg", "Ratio-desipramine Tab 100mg", "Ratio-desipramine Tab 10mg", "Ratio-desipramine Tab 25mg", "Ratio-desipramine Tab 50mg", "Ratio-desipramine Tab 75mg" ]	[ "Pertofran", "Pertofrane" ]	[]	[ "P23975", "P31645", "P28223", "P07550", "P08588", "P17405", "P35367", "P35348", "P35368", "P25100", "P11229", "P08172", "P20309", "P08173", "P08912", "P08908", "P28335", "P14416", "P08913", "P18089", "P18825" ]	[ "P10635", "P05177", "P08684", "P20813", "P05181" ]	[ "P02763" ]	[ "P08183", "O15245", "O75751", "O15244", "O76082", "Q9H015" ]
DB00459	Acitretin	An oral retinoid effective in the treatment of psoriasis. It is the major metabolite of etretinate with the advantage of a much shorter half-life when compared with etretinate.	solid	For the treatment of severe psoriasis in adults.	Acitretin is a retinoid. Retinoids have a structure similar to vitamin A and are involved in the normal growth of skin cells. Acitretin works by inhibiting the excessive cell growth and keratinisation (process by which skin cells become thickened due to the deposition of a protein within them) seen in psoriasis. It therefore reduces the thickening of the skin, plaque formation and scaling.	The mechanism of action of acitretin is unknown, however it is believed to work by targeting specific receptors (retinoid receptors such as RXR and RAR) in the skin which help normalize the growth cycle of skin cells.	Oral absorption of acitretin is optimal when given with food, and is linear and proportional with increasing doses from 25 to 100 mg. Approximately 72% (range 47% to 109%) of the administered dose was absorbed after a single 50 mg dose of acitretin was given to 12 healthy subjects.	Following oral absorption, acitretin undergoes extensive metabolism and interconversion by simple isomerization to its 13-cis form (cis-acitretin). Both parent compound and isomer are further metabolized into chain-shortened breakdown products and conjugates, which are excreted.	Oral, rat: LD<sub>50</sub> = >4000 mg/kg. Symptoms of overdose include headache and vertigo.	49 hours (range 33 to 96 hours)	Over 99.9% bound to plasma proteins, primarily albumin.	Both parent compound and isomer are further metabolized into chain-shortened breakdown products and conjugates, which are excreted. The chain-shortened metabolites and conjugates of acitretin and cis-acitretin are ultimately excreted in the feces (34% to 54%) and urine (16% to 53%).	null	null	Organic compounds	Lipids and lipid-like molecules	Prenol lipids	Retinoids	[ "approved" ]	[ "D05BB", "D05B", "D05", "D" ]	[ "Humans and other mammals" ]	[ { "cost": "13.25", "description": "Soriatane 10 mg capsule", "unit": "capsule" }, { "cost": "21.71", "description": "Soriatane 25 mg capsule", "unit": "capsule" }, { "cost": "30.21", "description": "Soriatane 17.5 mg capsule", "unit": "capsule" }, { "cost": "30.21", "description": "Soriatane 22.5 mg capsule", "unit": "capsule" } ]	[]	(all-E)-9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoic acid \| Acitretin \| Acitretina \| Acitretine \| Acitretinum \| all-trans-3,7-Dimethyl-9-(4-methoxy-2,3,6-trimethylphenyl)-2,4,6,8-nonatetraenoic acid \| Etretin \| NR2B1 \| Nuclear receptor subfamily 2 group B member 1 \| Retinoid X receptor alpha \| Acute-phase response factor \| APRF \| NR1B1 \| Nuclear receptor subfamily 1 group B member 1 \| RAR-alpha \| HAP \| HBV-activated protein \| NR1B2 \| Nuclear receptor subfamily 1 group B member 2 \| RAR-beta \| RAR-epsilon \| NR1B3 \| Nuclear receptor subfamily 1 group B member 3 \| RAR-gamma \| NR2B3 \| Nuclear receptor subfamily 2 group B member 3 \| Retinoid X receptor gamma \| NR2B2 \| Nuclear receptor subfamily 2 group B member 2 \| Retinoid X receptor beta \| Cellular retinol-binding protein \| Cellular retinol-binding protein I \| CRBP \| CRBP-I \| CRBP1	[ "Acitretin", "Acitretin", "Acitretin", "Acitretin", "Acitretin", "Acitretin", "Acitretin", "Acitretin", "Acitretin", "Acitretin", "Acitretin", "Acitretin", "Acitretin", "Acitretin", "Acitretin", "Acitretin", "Acitretin", "Acitretin", "Acitretin", "Acitretin", "Acitretin", "Acitretin", "Acitretin", "Acitretin", "Acitretin", "Acitretin", "Acitretin", "Acitretin", "Acitretin", "Acitretin", "Acitretin", "Acitretin", "Acitretin", "Acitretin", "Acitretin", "Jamp Acitretin", "Mint-acitretin", "Mint-acitretin", "Soriatane", "Soriatane", "Soriatane", "Soriatane", "Soriatane", "Soriatane", "Soriatane", "Soriatane", "Soriatane", "Soriatane", "Soriatane", "Taro-acitretin", "Taro-acitretin" ]	[ "Neotigason" ]	[]	[ "P19793", "P40763", "P10276", "P10826", "P13631", "P48443", "P28702", "P09455" ]	[]	[ "P02768" ]	[]
DB00460	Verteporfin	Verteporfin, marketed as Visudyne, is a benzoporphyrin derivative comprising a 50:50 mixture of two isomers: [CL-315555] and [CL-315585]. It is used as a photosensitizer in photodynamic therapy to eliminate abnormal blood vessels in wet form macular degeneration. Verteporfin accumulates in these abnormal blood vessels and, when stimulated by nonthermal red light with a wavelength of 693 nm in the presence of oxygen, produces highly reactive short-lived singlet oxygen and other reactive oxygen radicals, resulting in local damage to the endothelium and blockage of the vessels.	solid	For the treatment of patients with predominantly classic subfoveal choroidal neovascularization due to age-related macular degeneration, pathologic myopia or presumed ocular histoplasmosis syndrome. Verteporfin can also be used to destroy tumors.	Verteporfin, otherwise known as benzoporphyrin derivative, is a medication used in conjunction with laser treatment to eliminate the abnormal blood vessels in the eye associated with conditions such as the wet form of macular degeneration. Verteporfin accumulates in these abnormal blood vessels and, when stimulated by nonthermal red light with a wavelength of 693 nm in the presence of oxygen, produces highly reactive short-lived singlet oxygen and other reactive oxygen radicals, resulting in local damage to the endothelium and blockage of the vessels.	Verteporfin is transported in the plasma primarily by lipoproteins. Once verteporfin is activated by light in the presence of oxygen, highly reactive, short-lived singlet oxygen and reactive oxygen radicals are generated. Light activation of verteporfin results in local damage to neovascular endothelium, resulting in vessel occlusion. Damaged endothelium is known to release procoagulant and vasoactive factors through the lipo-oxygenase (leukotriene) and cyclo-oxygenase (eicosanoids such as thromboxane) pathways, resulting in platelet aggregation, fibrin clot formation and vasoconstriction. Verteporfin appears to somewhat preferentially accumulate in neovasculature, including choroidal neovasculature. However, animal models indicate that the drug is also present in the retina. As singlet oxygen and reactive oxygen radicals are cytotoxic, Verteporfin can also be used to destroy tumor cells.	null	Metabolized to a small extent to its diacid metabolite by liver and plasma esterases. NADPH-dependent liver enzyme systems (including the cytochrome P450 isozymes) do not appear to play a role in the metabolism of verteporfin.	Overdose of drug and/or light in the treated eye may result in nonperfusion of normal retinal vessels with the possibility of severe decrease in vision that could be permanent. An overdose of drug will also result in the prolongation of the period during which the patient remains photosensitive to bright light.	Following intravenous infusion, verteporfin exhibits a bi-exponential elimination with a terminal elimination half-life of approximately 5-6 hours. Mild hepatic insufficiency increases half-life by approximately 20%.	null	Elimination is by the fecal route, with less than 0.01% of the dose recovered in urine.	null	null	null	null	null	null	[ "approved", "investigational" ]	[ "S01LA", "S01L", "S01", "S" ]	[ "Humans and other mammals" ]	[ { "cost": "1702.64", "description": "Visudyne 15 mg vial", "unit": "vial" } ]	[ { "approved": "1993-05-25", "country": "United States", "expires": "2010-05-25", "number": "5214036" }, { "approved": "2008-06-03", "country": "Canada", "expires": "2014-03-14", "number": "2536069" }, { "approved": "1998-06-23", "country": "Canada", "expires": "2015-06-23", "number": "1339927" }, { "approved": "1998-05-26", "country": "United States", "expires": "2016-03-11", "number": "5756541" }, { "approved": "1998-08-25", "country": "United States", "expires": "2015-08-25", "number": "5798349" }, { "approved": "1998-01-13", "country": "United States", "expires": "2015-08-02", "number": "5707608" } ]	Verteporfin \| Verteporfina \| Vertéporfine \| Verteporfinum \| Apo-AI \| ApoA-I \| Apolipoprotein A1 \| Apo-AII \| ApoA-II \| Apolipoprotein A2 \| Apo-AIV \| ApoA-IV \| Apolipoprotein A4 \| Apo B-100 \| APC2 \| Apo-CII \| ApoC-II \| Apolipoprotein C2 \| Apo-CIII \| ApoC-III \| Apolipoprotein C3 \| Apo-D \| ApoD \| Apo-E \| Apo-L \| APOL \| ApoL-I \| Apolipoprotein L \| Apolipoprotein L-I \| Apo-M \| ApoM \| G3A \| NG20 \| Protein G3a \| 3.4.21.- \| Apo(a) \| Lp(a)	[ "Visudyne", "Visudyne", "Visudyne", "Visudyne", "Visudyne", "Visudyne" ]	[ "Visudine" ]	[]	[]	[]	[ "P02647", "P02652", "P06727", "P04114", "P02655", "P02656", "P05090", "P02649", "O14791", "O95445", "P08519" ]	[]
DB00462	Methscopolamine bromide	A muscarinic antagonist used to study binding characteristics of muscarinic cholinergic receptors.	solid	Used as adjunctive therapy for the treatment of peptic ulcer. Also used to treat nausea and vomiting due to motion sickness.	Methscopolamine is a muscarinic antagonist structurally similar to the neurotransmitter acetylcholine and acts by blocking the muscarinic acetylcholine receptors and is thus classified as an anticholinergic. Methscopolamine has many uses including the prevention of motion sickness. It is not clear how Methscopolamine prevents nausea and vomiting due to motion sickness. The vestibular part of the ear is very important for balance. When a person becomes disoriented due to motion, the vestibule sends a signal through nerves to the vomiting center in the brain, and vomiting occurs. Acetylcholine is a chemical that nerves use to transmit messages to each other. It is believe that Methscopolamine prevents communication between the nerves of the vestibule and the vomiting center in the brain by blocking the action of acetylcholine. Methscopolamine also may work directly on the vomiting center. Methscopolamine must be taken before the onset of motion sickness to be effective.	Methscopolamine acts by interfering with the transmission of nerve impulses by acetylcholine in the parasympathetic nervous system (specifically the vomiting center). It does so by acting as a muscarinic antagonist.	Poorly and unreliably absorbed, total absorption is 10-25%.	Little is known about the fate and excretion of methscopolamine.	Symptoms of a methscopolamine overdose include headache, nausea, vomiting, dry mouth, difficulty swallowing, blurred vision, dilated pupils, hot, dry skin, dizziness; drowsiness, confusion, anxiety, seizures, weak pulse, and an irregular heartbeat. In addition, a curare-like action may occur, i.e., neuromuscular blockade leading to muscular weakness and possible paralysis.	null	null	null	null	null	null	null	null	null	[ "approved" ]	[]	[ "Humans and other mammals" ]	[ { "cost": "2.09", "description": "Methscopolamine brom 5 mg tablet", "unit": "tablet" }, { "cost": "2.72", "description": "Pamine 2.5 mg tablet", "unit": "tablet" }, { "cost": "2.77", "description": "Pamine fq dose pack kit", "unit": "each" }, { "cost": "12.01", "description": "Transderm-scop 1.5 mg/72hr", "unit": "each" }, { "cost": "12.04", "description": "Transderm-Scop 1.5 mg (1 Box Contains 10 Patches)", "unit": "patch" }, { "cost": "14.87", "description": "Transderm-Scop 1.5 mg (1 Box Contains 4 Patches)", "unit": "patch" }, { "cost": "234.68", "description": "Pamine Forte 60 5 mg tablet Box", "unit": "box" } ]	[]	(−)-scopolamine methobromide \| (−)-scopolamine methyl bromide \| Hyoscine methobromide \| Hyoscine methyl bromide \| Methscopolamine bromide \| Methylscopolamine bromide \| N-methylhyoscine bromide \| N-methylscopolammonium bromide \| Scopolamine methobromide \| Scopolamine methyl bromide	[ "Methscopolamine", "Methscopolamine Bromide", "Methscopolamine Bromide", "Methscopolamine Bromide", "Methscopolamine Bromide", "Methscopolamine Bromide", "Methscopolamine Bromide", "Methscopolamine Bromide", "Methscopolamine Bromide", "Methscopolamine Bromide", "Methscopolamine Bromide", "Methscopolamine Bromide", "Methscopolamine Bromide", "Methscopolamine Bromide", "Methscopolamine Bromide", "Methscopolamine Bromide", "Methscopolamine Bromide", "Pamine", "Pamine", "Pamine Forte", "Pamine Forte" ]	[ "Pamine" ]	[]	[ "P08172", "P11229", "P20309" ]	[]	[]	[]
DB00463	Metharbital	Metharbital is a barbiturate anticonvulsant, similar to phenobarbital, marketed as Gemonil by Abbott Laboratories. It was patented in 1905 by Emil Fischer of Merck.	solid	Metharbital is used for the treatment of epilepsy.	Metharbital, a barbiturate, is used for the treatment of short term insomnia. It belongs to a group of medicines called central nervous system (CNS) depressants that induce drowsiness and relieve tension or nervousness. Little analgesia is conferred by barbiturates; their use in the presence of pain may result in excitation.	Metharbital binds at a distinct binding site associated with a Cl<sup>-</sup> ionopore at the GABA<sub>A</sub> receptor, increasing the duration of time for which the Cl<sup>-</sup> ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged. All of these effects are associated with marked decreases in GABA-sensitive neuronal calcium conductance (gCa). The net result of barbiturate action is acute potentiation of inhibitory GABAergic tone. Barbiturates also act through potent (if less well characterized) and direct inhibition of excitatory AMPA-type glutamate receptors, resulting in a profound suppression of glutamatergic neurotransmission.	null	null	Signs of overdose include confusion (severe), decrease in or loss of reflexes, drowsiness (severe), fever, irritability (continuing), low body temperature, poor judgment, shortness of breath or slow or troubled breathing, slow heartbeat, slurred speech, staggering, trouble in sleeping, unusual movements of the eyes, weakness (severe).	null	null	null	null	null	Organic compounds	Organoheterocyclic compounds	Diazines	Pyrimidines and pyrimidine derivatives	[ "withdrawn" ]	[ "N03AA", "N03A", "N03", "N" ]	[ "Humans and other mammals" ]	[]	[]	Metarbital \| Metharbital \| Metharbitalum \| GABA(A) receptor subunit alpha-2 \| GABAAR subunit alpha-2 \| GABA(A) receptor subunit gamma-3 \| GABAAR subunit gamma-3 \| GABA(A) receptor subunit alpha-3 \| GABAAR subunit alpha-3 \| GABA(A) receptor subunit alpha-4 \| GABAAR subunit alpha-4 \| GABA(A) receptor subunit alpha-5 \| GABAAR subunit alpha-5 \| GABA(A) receptor subunit alpha-6 \| GABAAR subunit alpha-6 \| GABA(A) receptor subunit alpha-1 \| GABAAR subunit alpha-1 \| GABA(A) receptor subunit alpha-2 \| GABAAR subunit alpha-2 \| GABA(A) receptor subunit alpha-3 \| GABAAR subunit alpha-3 \| GABA(A) receptor subunit alpha-4 \| GABAAR subunit alpha-4 \| GABA(A) receptor subunit alpha-5 \| GABAAR subunit alpha-5 \| GABA(A) receptor subunit alpha-6 \| GABAAR subunit alpha-6 \| GABA(A) receptor subunit beta-1 \| GABAAR subunit beta-1 \| GABA(A) receptor subunit beta-2 \| GABAAR subunit beta-2 \| GABA(A) receptor subunit beta-3 \| GABAAR subunit beta-3 \| GABA(A) receptor subunit delta \| GABAAR subunit delta \| GABA(A) receptor subunit epsilon \| GABAAR subunit epsilon \| GABA(A) receptor subunit gamma-1 \| GABAAR subunit gamma-1 \| GABA(A) receptor subunit gamma-2 \| GABAAR subunit gamma-2 \| GABA(A) receptor subunit gamma-3 \| GABAAR subunit gamma-3 \| GABA(A) receptor subunit pi \| GABAAR subunit pi \| GABA(A) receptor subunit theta \| GABAAR subunit theta \| GABA(A) receptor subunit alpha-1 \| GABAAR subunit alpha-1 \| NACRA4 \| NACHRA7 \| AMPA-selective glutamate receptor 2 \| GluA2 \| GluR-2 \| GluR-B \| GluR-K2 \| GLUR2 \| Glutamate receptor ionotropic, AMPA 2 \| EAA4 \| Excitatory amino acid receptor 4 \| GluK2 \| GluR-6 \| GLUR6 \| Glutamate receptor 6	[]	[ "Gemonil" ]	[]	[ "P47869", "Q99928", "P34903", "P48169", "P31644", "Q16445", "P14867", "P47869", "P34903", "P48169", "P31644", "Q16445", "P18505", "P47870", "P28472", "O14764", "P78334", "Q8N1C3", "P18507", "Q99928", "O00591", "Q9UN88", "P14867", "P43681", "P36544", "P42262", "Q13002" ]	[]	[]	[]
DB00464	Sodium tetradecyl sulfate	An anionic surface-active agent used for its wetting properties in industry and used in medicine as an irritant and sclerosing agent for hemorrhoids and varicose veins.	solid	For the treatment of small uncomplicated varicose veins of the lower extremities that show simple dilation with competent valves.	Sodium tetradecyl sulfate is an anionic surfactant which occurs as a white, waxy solid. It is used as a sclerosing agent in sclerotherapy. Sclerotherapy is an injection of a sclerosing agent directly through the skin into a lesion and is used primarily for slow-flow vascular anomalies, particularly for venous malformation and lymphatic malformation. Intravenous injection causes intima inflammation and thrombus formation. This usually occludes the injected vein. Subsequent formation of fibrous tissue results in partial or complete vein obliteration that may or may not be permanent.	Sodium tetradecyl sulfate is a potent toxin for endothelial cells in that brief exposure to even low concentrations are effective in stripping endothelium over a considerable distance and exposing highly thrombogenic endothelium in the process. Diluted sodium tetradecyl sulfate is also able to induce a hypercoagulable state, possibly by selective inhibition of protein C, and can also promote platelet aggregation.	null	null	LD<sub>50</sub>=1250 mg/kg (Orally in rat); LD<sub>50</sub>=3 ml/kg (Skin in rat)	null	null	null	null	null	Organic compounds	Organic acids and derivatives	Organic sulfuric acids and derivatives	Sulfuric acid esters	[ "approved", "investigational" ]	[ "C05BB", "C05B", "C05", "C" ]	[ "Humans and other mammals" ]	[ { "cost": "3.46", "description": "Tromboject 1 %", "unit": "ml" }, { "cost": "3.77", "description": "Tromboject 3 %", "unit": "ml" }, { "cost": "19.68", "description": "Sotradecol 1% vial", "unit": "ml" }, { "cost": "33.0", "description": "Sotradecol 3% vial", "unit": "ml" } ]	[]	7-Ethyl-2-methyl-4-undecanol sulfate sodium salt \| 7-ethyl-2-methyl-4-undecanolsulfate, sodium salt \| Natrii tetradecylis sulfa \| Sodium 2-methyl-7-ethylundecanol-4-sulfate \| Sodium 7-ethyl-2-methyl-4-undecanol sulfate \| Sodium tetradecyl sulfate \| Sodium tetradecyl sulphate \| Sodium tetradecylsulfate \| STS \| Tetradecilsulfato sodico \| Tetradecyl sodium sulfate \| Tetradecyl sulfate de sodium \| PROS \| 3.4.21.69 \| Anticoagulant protein C \| Autoprothrombin IIA \| Blood coagulation factor XIV	[ "Sodium Tetradecyl Sulfate", "Sotradecol", "Sotradecol", "Tromboject 1%", "Tromboject 3%", "Trombovar Inj 1%", "Trombovar Inj 3%" ]	[ "Fibro-Vein" ]	[]	[ "P07225", "P04070" ]	[]	[]	[]
DB00466	Picrotoxin	A noncompetitive antagonist at GABA-A receptors and thus a convulsant. Picrotoxin blocks the gamma-aminobutyric acid-activated chloride ionophore. Although it is most often used as a research tool, it has been used as a CNS stimulant and an antidote in poisoning by CNS depressants, especially the barbiturates. [PubChem]	solid	Used internally for relieving respiratory distress. Also for use as an antidote in poisoning by CNS depressants, especially barbiturates.	Picrotoxin is a toxin obtained from the seeds of the shrub <i>Anamirta cocculus</i>. It is used as a central nervous system stimulant, antidote, convulsant, and GABA (gamma aminobutyric acid) antagonist. It is a noncompetitive antagonist at GABA<sub>A</sub> receptors and thus a convulsant. Picrotoxin blocks the GABA<sub>A</sub>ctivated chloride ionophore. Although it is most often used as a research tool, it has been used as a CNS stimulant and an antidote in poisoning by CNS depressants, especially barbiturates.	Picrotoxin antagonizes the GABA<sub>A</sub> receptor channel directly, which is a ligand-gated ion channel concerned chiefly with the passing of chloride ions across the cell membrane. Therefore picrotoxin prevents Cl<sup>-</sup> channel permeability and thus promtes an inhibitory influence on the target neuron. Picrotoxin reduces conductance through the channel by reducing not only the opening frequency but also the mean open time. Picrotoxin also antagonizes GABA<sub>C</sub> receptors (also called GABA<sub>A</sub>-rho receptors) but the result of this action is not known. The GABA<sub>C</sub> receptor is also linked to chloride channels, with distinct physiological and pharmacological properties. In contrast to the fast and transient responses elicited from GABA<sub>A</sub> receptors, GABA<sub>C</sub> receptors mediate slow and sustained responses.	null	null	Oral, mouse: LD<sub>50</sub> = 15 mg/kg. In large doses it is a powerful poison, causing unconsciousness, delirium, convulsions, gastro-enteritis and stimulation of the respiratory centre followed by paralysis, from which death sometimes results.	null	null	null	null	null	Organic compounds	Organoheterocyclic compounds	Furopyrans	null	[ "experimental" ]	[]	[ "Humans and other mammals" ]	[]	[]	cocculin \| GABA(A) receptor subunit rho-1 \| GABA(C) receptor \| GABAAR subunit rho-1 \| GABA(A) receptor subunit alpha-1 \| GABAAR subunit alpha-1 \| Glycine receptor 48 kDa subunit \| Glycine receptor strychnine-binding subunit \| 1.14.14.1 \| CYPIA1 \| Cytochrome P450 form 6 \| Cytochrome P450-C \| Cytochrome P450-P1 \| Hydroperoxy icosatetraenoate dehydratase \| 6.3.1.2 \| GLNS \| Glutamate--ammonia ligase \| GS \| Palmitoyltransferase GLUL	[]	[]	[]	[ "P24046", "P14867", "P23416", "O75311", "P23415" ]	[ "P04798", "P15104" ]	[]	[]
DB00467	Enoxacin	A broad-spectrum 6-fluoronaphthyridinone antibacterial agent (fluoroquinolones) structurally related to nalidixic acid.	solid	For the treatment of adults (≥18 years of age) with the following infections caused by susceptible strains of the designated microorganisms: (1) uncomplicated urethral or cervical gonorrhea due to <i>Neisseria gonorrhoeae</i>, (2) uncomplicated urinary tract infections (cystitis) due to <i>Escherichia coli</i>, <i>Staphylococcus epidermidis</i>, or <i>Staphylococcus saprophyticus</i>, and (3) complicated urinary tract infections due to <i>Escherichia coli</i>, <i>Klebsiella pneumoniae</i>, <i>Proteus mirabilis</i>, <i>Pseudomonas aeruginosa</i>, <i>Staphylococcus epidermidis</i>, or <i>Enterobacter cloacae</i>.	Enoxacin is a quinolone/fluoroquinolone antibiotic. Enoxacin is bactericidal and its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase, which allows the untwisting required to replicate one DNA double helix into two. Enoxacin is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria. Enoxacin may be active against pathogens resistant to drugs that act by different mechanisms.	Enoxacin exerts its bactericidal action via the inhibition of the essential bacterial enzyme DNA gyrase (DNA Topoisomerase II).	Rapidly absorbed following oral administration, with an absolute oral bioavailability of approximately 90%.	Hepatic. Some isozymes of the cytochrome P-450 hepatic microsomal enzyme system are inhibited by enoxacin. After a single dose, greater than 40% was recovered in urine by 48 hours as unchanged drug.	null	Plasma half-life is 3 to 6 hours.	Enoxacin is approximately 40% bound to plasma proteins in healthy subjects and is approximately 14% bound to plasma proteins in patients with impaired renal function.	null	null	null	Organic compounds	Organoheterocyclic compounds	Diazanaphthalenes	Naphthyridines	[ "approved", "investigational" ]	[ "J01MA", "J01M", "J01", "J" ]	[ "Enteric bacteria and other eubacteria" ]	[]	[]	1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1,8-naphthyridine-3-carboxylic acid \| 1-Ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid \| Enoxacin \| Enoxacina \| Énoxacine \| Enoxacino \| Enoxacinum \| 5.6.2.2 \| DNA topoisomerase II, beta isozyme \| 5.99.1.3 \| 5.99.1.3 \| Topoisomerase IV subunit A \| 5.6.2.2 \| DNA topoisomerase II, alpha isozyme \| TOP2 \| 1.14.14.1 \| Cholesterol 25-hydroxylase \| CYPIA2 \| Cytochrome P(3)450 \| Cytochrome P450 4 \| Cytochrome P450-P3 \| Hydroperoxy icosatetraenoate dehydratase	[]	[ "Almitil", "Bactidan", "Comprecin", "Enoksetin", "Enoxen", "Enoxin", "Enoxor", "Enroxil", "Flumark", "Gyramid", "Penetrex", "Vinone" ]	[]	[ "Q02880", "P11388" ]	[ "P05177" ]	[]	[]
DB00468	Quinine	An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It was used commonly and as a bitter and flavoring agent, and is still useful for the treatment of babesiosis. Quinine is also useful in some muscular disorders, especially nocturnal leg cramps and myotonia congenita, because of its direct effects on muscle membrane and sodium channels. The mechanisms of its antimalarial effects are not well understood. Quinine (GLS-1200) was also investigated in clinical trials for its efficacy in preventing SARS-CoV-2 infection (NCT04408183, terminated) and is planned to be evaluated for preventing sinusitis after endoscopic sinus surgery (NCT04060316).	solid	For the treatment of malaria and leg cramps	Quinine is used parenterally to treat life-threatening infections caused by chloroquine-resistant Plasmodium falciparum malaria. Quinine acts as a blood schizonticide although it also has gametocytocidal activity against P. vivax and P. malariae. Because it is a weak base, it is concentrated in the food vacuoles of P. falciparum. It is thought to act by inhibiting heme polymerase, thereby allowing accumulation of its cytotoxic substrate, heme. As a schizonticidal drug, it is less effective and more toxic than chloroquine. However, it has a special place in the management of severe falciparum malaria in areas with known resistance to chloroquine.	The theorized mechanism of action for quinine and related anti-malarial drugs is that these drugs are toxic to the malaria parasite. Specifically, the drugs interfere with the parasite's ability to break down and digest hemoglobin. Consequently, the parasite starves and/or builds up toxic levels of partially degraded hemoglobin in itself.	76 - 88%	Hepatic, over 80% metabolized by the liver.	Quinine is a documented causative agent of drug induced thrombocytopenia (DIT). Thrombocytopenia is a low amount of platelets in the blood. Quinine induces production of antibodies against glycoprotein (GP) Ib-IX complex in the majority of cases of DIT, or more rarely, the platelet-glycoprotein complex GPIIb-IIIa. Increased antibodies against these complexes increases platelet clearance, leading to the observed thrombocytopenia.	Approximately 18 hours	Approximately 70%	Quinine is eliminated primarily via hepatic biotransformation. Approximately 20% of quinine is excreted unchanged in urine.	* 1.43 ± 0.18 L/kg [Healthy Pediatric Controls] * 0.87 ± 0.12 L/kg [P. falciparum Malaria Pediatric Patients] * 2.5 to 7.1 L/kg [healthy subjects who received a single oral 600 mg dose]	* 0.17 L/h/kg [healthy] * 0.09 L/h/kg [patients with uncomplicated malaria] * 18.4 L/h [healthy adult subjects with administration of multiple-dose activated charcoal] * 11.8 L/h [healthy adult subjects without administration of multiple-dose activated charcoal] * Oral cl=0.06 L/h/kg [elderly subjects]	Organic compounds	Alkaloids and derivatives	Cinchona alkaloids	null	[ "approved" ]	[ "M09AA", "M09A", "M09", "M", "P01BC", "P01B", "P01", "P" ]	[ "Humans and other mammals" ]	[ { "cost": "25.86", "description": "Quinine sulfate powd ultrex", "unit": "g" }, { "cost": "0.25", "description": "Apo-Quinine 200 mg Capsule", "unit": "capsule" }, { "cost": "0.25", "description": "Novo-Quinine 200 mg Capsule", "unit": "capsule" }, { "cost": "0.39", "description": "Apo-Quinine 300 mg Capsule", "unit": "capsule" }, { "cost": "0.39", "description": "Novo-Quinine 300 mg Capsule", "unit": "capsule" } ]	[]	(-)-Quinine \| (−)-quinine \| (8S,9R)-quinine \| (R)-(−)-quinine \| (R)-(6-methoxyquinolin-4-yl)((2S,4S,8R)-8-vinylquinuclidin-2-yl)methanol \| 6'-Methoxycinchonidine \| Chinin \| Chinine \| Chininum \| Quinina \| Quinine \| Glycoprotein 9 \| GP-IX \| GPIX \| Gardos channel \| hIK1 \| hKCa4 \| hSK4 \| IK1 \| IKCA1 \| KCa3.1 \| KCA4 \| Putative Gardos channel \| SK4 \| SKCa 4 \| SKCa4 \| 1,4-cineole 2-exo-monooxygenase \| 1,8-cineole 2-exo-monooxygenase \| 1.14.14.1 \| Albendazole monooxygenase (sulfoxide-forming) \| Albendazole sulfoxidase \| Cholesterol 25-hydroxylase \| CYP3A3 \| CYPIIIA3 \| CYPIIIA4 \| Cytochrome P450 3A3 \| Cytochrome P450 HLp \| Cytochrome P450 NF-25 \| Cytochrome P450-PCN1 \| Nifedipine oxidase \| Quinine 3-monooxygenase \| 1.14.14.1 \| CYPIIIA5 \| Cytochrome P450-PCN3 \| 1.14.14.1 \| CYPIA1 \| Cytochrome P450 form 6 \| Cytochrome P450-C \| Cytochrome P450-P1 \| Hydroperoxy icosatetraenoate dehydratase \| 1.14.14.- \| Cholesterol 25-hydroxylase \| CYP2DL1 \| CYPIID6 \| Cytochrome P450-DB1 \| Debrisoquine 4-hydroxylase \| 1.14.14.1 \| Cholesterol 25-hydroxylase \| CYPIA2 \| Cytochrome P(3)450 \| Cytochrome P450 4 \| Cytochrome P450-P3 \| Hydroperoxy icosatetraenoate dehydratase \| 1.14.14.1 \| CYPIIC8 \| Cytochrome P450 form 1 \| Cytochrome P450 IIC2 \| Cytochrome P450 MP-12 \| Cytochrome P450 MP-20 \| S-mephenytoin 4-hydroxylase \| (R)-limonene 6-monooxygenase \| (S)-limonene 6-monooxygenase \| (S)-limonene 7-monooxygenase \| 1.14.14.1 \| Cholesterol 25-hydroxylase \| CYP2C10 \| CYPIIC9 \| Cytochrome P-450MP \| Cytochrome P450 MP-4 \| Cytochrome P450 MP-8 \| Cytochrome P450 PB-1 \| S-mephenytoin 4-hydroxylase \| (R)-limonene 6-monooxygenase \| (S)-limonene 6-monooxygenase \| (S)-limonene 7-monooxygenase \| 1.14.14.1 \| CYPIIC17 \| CYPIIC19 \| Cytochrome P450-11A \| Cytochrome P450-254C \| Fenbendazole monooxygenase (4'-hydroxylating) \| Mephenytoin 4-hydroxylase \| 1.14.14.1 \| 4-nitrophenol 2-hydroxylase \| CYP2E \| CYPIIE1 \| Cytochrome P450-J \| 1.14.14.1 \| CYPIIIA7 \| Cytochrome P450-HFLA \| P450HLp2 \| hOCT2 \| OCT2 \| Organic cation transporter 2 \| hOCT1 \| OCT1 \| Organic cation transporter 1 \| High-affinity sodium-dependent carnitine cotransporter \| OCTN2 \| Solute carrier family 22 member 5 \| ATP-binding cassette sub-family B member 1 \| MDR1 \| Multidrug resistance protein 1 \| P-glycoprotein 1 \| PGY1 \| Phospholipid transporter ABCB1 \| OATP \| OATP-1 \| OATP-A \| OATP1 \| OATP1A2 \| Organic anion-transporting polypeptide 1 \| SLC21A3 \| Sodium-independent organic anion transporter \| Solute carrier family 21 member 3 \| Ergothioneine transporter \| ET transporter \| ETT \| ETTh \| OCTN1 \| Organic cation/carnitine transporter 1 \| UT2H \| Liver-specific organic anion transporter 1 \| LST-1 \| LST1 \| OATP-2 \| OATP-C \| OATP1B1 \| OATP2 \| OATPC \| Organic anion transporter SLC21A6 \| SLC21A6 \| SLCO1B1 \| Sodium-independent organic anion-transporting polypeptide 2 \| Solute carrier family 21 member 6	[ "Apo-quinine", "Apo-quinine", "Jamp-quinine", "Jamp-quinine", "Pro-quinine - 200", "Pro-quinine - 300", "Qualaquin", "Qualaquin", "Qualaquin", "Qualaquin", "Quinine - Odan", "Quinine - Odan", "Quinine - Odan", "Quinine Sulfate", "Quinine Sulfate", "Quinine Sulfate", "Quinine Sulfate", "Quinine Sulfate", "Quinine Sulfate", "Quinine Sulfate", "Quinine Sulfate", "Quinine Sulfate", "Quinine Sulfate", "Quinine Sulfate", "Quinine Sulfate", "Quinine Sulfate Cap 200mg", "Quinine Sulfate Cap 200mg", "Quinine Sulfate Cap 300mg", "Quinine Sulfate Cap 300mg", "Quinine Sulfate Capsules 200mg", "Quinine Sulfate Capsules 300mg", "Teva-quinine", "Teva-quinine" ]	[ "Cinkona", "Jasoquin", "QSM", "Quinlup", "Qutil", "Sulquin" ]	[]	[ "P14770", "O15554" ]	[ "P08684", "P20815", "P04798", "P10635", "P05177", "P10632", "P11712", "P33261", "P05181", "P24462" ]	[]	[ "O15244", "O15245", "O76082", "P08183", "P46721", "Q9H015", "Q9Y6L6" ]
DB00469	Tenoxicam	Tenoxicam, an antiinflammatory agent with analgesic and antipyretic properties, is used to treat osteoarthritis and control acute pain.	solid	For the treatment of rheumatoid arthritis, osteoarthritis, backache, and pain.	Tenoxicam, an antiinflammatory agent with analgesic and antipyretic properties, is used to treat osteoarthritis and control acute pain.	The antiinflammatory effects of tenoxicam may result from the inhibition of the enzyme cycooxygenase and the subsequent peripheral inhibition of prostaglandin synthesis. As prostaglandins sensitize pain receptors, their inhibition accounts for the peripheral analgesic effects of tenoxicam. Antipyresis may occur by central action on the hypothalamus, resulting in peripheral dilation, increased cutaneous blood flow, and subsequent heat loss.	Oral absorption of tenoxicam is rapid and complete (absolute bioavailability 100%).	Tenoxicam is metabolized in the liver to several pharmacologically inactive metabolites (mainly 5'-hydroxy-tenoxicam).	null	72 hours (range 59 to 74 hours)	99%	null	null	null	Organic compounds	Organic acids and derivatives	Carboxylic acids and derivatives	Amino acids, peptides, and analogues	[ "approved" ]	[ "M01AC", "M01A", "M01", "M" ]	[ "Humans and other mammals" ]	[ { "cost": "1.21", "description": "Apo-Tenoxicam 20 mg Tablet", "unit": "tablet" } ]	[]	Tenoxicam \| Ténoxicam \| Tenoxicamum \| 1.14.99.1 \| COX-2 \| COX2 \| Cyclooxygenase-2 \| PGH synthase 2 \| PGHS-2 \| PHS II \| Prostaglandin H2 synthase 2 \| Prostaglandin-endoperoxide synthase 2 \| 1.14.99.1 \| COX-1 \| COX1 \| Cyclooxygenase-1 \| PGH synthase 1 \| PGHS-1 \| PHS 1 \| Prostaglandin H2 synthase 1 \| Prostaglandin-endoperoxide synthase 1 \| (R)-limonene 6-monooxygenase \| (S)-limonene 6-monooxygenase \| (S)-limonene 7-monooxygenase \| 1.14.14.1 \| Cholesterol 25-hydroxylase \| CYP2C10 \| CYPIIC9 \| Cytochrome P-450MP \| Cytochrome P450 MP-4 \| Cytochrome P450 MP-8 \| Cytochrome P450 PB-1 \| S-mephenytoin 4-hydroxylase \| hOAT3 \| OAT3 \| Organic anion/dicarboxylate exchanger \| Solute carrier family 22 member 8	[ "Mobiflex Tab 20mg", "Novo-tenoxicam Tab 20mg", "Tenoxicam", "Tenoxicam", "Tenoxicam-20" ]	[ "Mobiflex", "Octiveran", "Oxicam", "Oxytel", "Palitenox", "Tenorix", "Tenxil", "Tilcotil", "Tilflam", "Tilko", "Tilnoxcam", "Tiloxican", "Tobitil", "Tonox", "Toscacalm", "Velasor", "Vienoks", "Voir", "Xicotil", "Zibelant", "Zikaral" ]	[]	[ "P35354", "P23219" ]	[ "P11712" ]	[]	[ "Q8TCC7" ]
DB00470	Dronabinol	Dronabinol (marketed as Marinol) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). THC demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, which results in the well-known effects of smoking cannabis such as increased appetite, reduced pain, and changes in emotional and cognitive processes. Due to its evidence as an appetite stimulant and an anti-nauseant, Dronabinol is approved for use in anorexia associated with weight loss in patients with AIDS and for the treatment of nausea and vomiting associated with cancer chemotherapy in patients who have failed to respond adequately to conventional antiemetic treatments [FDA Label]. Tetrahydrocannabinol (THC) and cannabidiol (CBD) are the two most abundant cannabinoids found naturally in the resin of the marijuana plant, both of which are pharmacologically active due to their interaction with cannabinoid receptors that are found throughout the body [A32830]. While both CBD and THC are used for medicinal purposes, they have different receptor activity, function, and physiological effects. If not provided in their activated form (such as through synthetic forms like Dronabinol or [DB00486]), THC and CBD are obtained through conversion from their precursors, tetrahydrocannabinolic acid-A (THCA-A) and cannabidiolic acid (CBDA), through decarboxylation reactions. This can be achieved through heating, smoking, vaporization, or baking of dried unfertilized female cannabis flowers. From a pharmacological perspective, Cannabis' diverse receptor profile explains its potential application for such a wide variety of medical conditions. Cannabis contains more than 400 different chemical compounds, of which 61 are considered cannabinoids, a class of compounds that act upon endogenous cannabinoid receptors of the body [A32584]. The endocannabinoid system is widely distributed throughout the central and peripheral nervous system (via the Cannabinoid Receptors CB1 and CB2) and plays a role in many physiological processes such as inflammation, cardiovascular function, learning, pain, memory, stress and emotional regulation, and the sleep/wake cycle among many others [A32824]. CB1 receptors are found in both the central and peripheral nervous system, and are most abundant in the hippocampus and amygdala, which are the areas of the brain responsible for short-term memory storage and emotional regulation. CB2 receptors are mainly located in the peripheral nervous system and can be found on lymphoid tissue where they are involved in regulation of immune function [A32676].	solid	Dronabinol is indicated for the treatment of anorexia associated with weight loss in patients with AIDS, and nausea and vomiting associated with cancer chemotherapy in patients who have failed to respond adequately to conventional antiemetic treatments.[L43438]	Dronabinol-induced sympathomimetic activity may result in tachycardia and/or conjunctival injection. Its effects on blood pressure are inconsistent, but subjects have experienced orthostatic hypotension and/or syncope upon abrupt standing.[L43438] Dronabinol also demonstrates reversible effects on appetite, mood, cognition, memory, and perception. These phenomena appear to be dose-related, increasing in frequency with higher dosages, and subject to great inter-patient variability. After oral administration, dronabinol capsules have an onset of action of approximately 0.5 to 1 hour and a peak effect at 2 to 4 hours. Duration of action for psychoactive effects is 4 to 6 hours, but the appetite stimulant effect of dronabinol may continue for 24 hours or longer after administration.[L43438] Tachyphylaxis and tolerance develop to some of the cardiovascular and CNS pharmacologic effects of dronabinol with chronic use, suggesting an indirect effect on sympathetic neurons. In a study of the pharmacodynamics of chronic dronabinol exposure, healthy male subjects (N = 12) received 12 times the maximum dose for anorexia associated with weight loss in patients with AIDS of dronabinol capsules in divided doses for 16 days. An initial tachycardia induced by dronabinol was replaced successively by normal sinus rhythm and then bradycardia. A decrease in supine blood pressure, made worse by standing, was also observed initially. These subjects developed tolerance to the cardiovascular and subjective adverse CNS effects of dronabinol within 12 days of treatment initiation.[L43438] Tachyphylaxis and tolerance do not appear to develop to the appetite stimulant effect of dronabinol. In clinical studies of dronabinol capsules in AIDS patients, at the recommended dosage, the appetite stimulant effect was sustained for up to five months.[L43438]	Dronabinol is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). THC demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, which results in the well-known effects of smoking cannabis such as increased appetite, reduced pain, and changes in emotional and cognitive processes.	Dronabinol is almost completely absorbed (90 to 95%) after a single oral dose. Due to the combined effects of first-pass hepatic metabolism and high lipid solubility, only 10 to 20% of the administered dose reaches systemic circulation. Relative bioavailability data from healthy male and female subjects suggest that a dose of 4.2 mg of SYNDROS provides comparable systemic exposure (Cmax and AUC) to a 5 mg dronabinol capsule, under fasted conditions, with the C<sub>max</sub> and AUC<sub>inf</sub> of 1.9 ± 1.3 ng/mL and 3.8 ± 1.8 ng.h/mL respectively. The concentrations of both dronabinol and its major active metabolite (11-hydroxy-delta-9-THC) peak at approximately 0.5 to 4 hours after oral dosing with SYNDROS and decline over several days. The mean inter- and intra-subject variability in dronabinol pharmacokinetics (C<sub>max</sub> and AUC<sub>inf</sub>) was approximately 66% and 47% and 67% and 14%, respectively, following the administration of SYNDROS to healthy subjects.[L43438]	THC is primarily metabolized in the liver by microsomal hydroxylation and oxidation reactions catalyzed by Cytochrome P450 enzymes. 11-hydroxy-▵9-tetrahydrocannabinol (11-OH-THC) is the primary active metabolite, capable of producing psychological and behavioural effects, which is then metabolized into 11-nor-9-carboxy-▵ 9-tetrahydrocannabinol (THC-COOH), THC's primary inactive metabolite [A32584]. Dronabinol and its principal active metabolite, 11-OH-delta-9-THC, are present in approximately equal concentrations in plasma. Concentrations of both parent drug and metabolite peak at approximately 0.5 to 4 hours after oral dosing and decline over several days [FDA Label].	SYNDROS, a synthetic cannabinoid containing alcohol, may cause fetal harm. Avoid the use of SYNDROS in pregnant women. Although there is little published data on the use of synthetic cannabinoids during pregnancy, the use of cannabis (e.g., marijuana) and the use of alcohol during pregnancy have been associated with adverse fetal/neonatal outcomes (see Clinical Considerations). Cannabinoids have been found in the umbilical cord blood of pregnant women who smoke cannabis. In animal reproduction studies, no teratogenicity was reported in mice administered dronabinol (delta-9-THC) at up to 30 times the MRHD (maximum recommended human doses) and up to 5 times the MRHD for patients with AIDS and cancer, respectively. Similar findings were reported in pregnant rats administered dronabinol at up to 5 to 20 times the MRHD and 3 times the MRHD for patients with AIDS and cancer, respectively. Decreased maternal weight gain and the number of viable pups and increased fetal mortality and early resorptions were observed in both species at doses that induced maternal toxicity. In rats, maternal administration of dronabinol from pregnancy (implantation) through weaning was associated with maternal toxicity, including mortality of pups, and adverse developmental and 10 neurodevelopmental effects on the pups at 2 to 20 times the MRHD for patients with AIDS and less than and up to 3.3 times the MRHD for patients with cancer.[L43438] The estimated background risk of major birth defects and miscarriage for the indicated populations is unknown. All pregnancies have a background risk of birth defect, loss, or other adverse outcomes. In the U.S. general population, the estimated background risk of major birth defects and miscarriage in clinically recognized pregnancies is 2 to 4% and 15 to 20%, respectively.[L43438] For mothers infected with the Human Immunodeficiency Virus (HIV), the Centers for Disease Control and Prevention recommend that HIV-infected mothers not breastfeed their infants to avoid risking postnatal transmission of HIV. Because of the potential for HIV transmission (in 12 HIV-negative infants) and serious adverse reactions in a breastfed infant, instruct mothers not to breastfeed if they are receiving SYNDROS. For mothers with nausea and vomiting associated with cancer chemotherapy, there are limited data on the presence of dronabinol in human milk, the effects on the breastfed infant, or the effects on milk production. The reported effects of inhaled cannabis transferred to the breastfeeding infant have been inconsistent and insufficient to establish causality. The developmental and health benefits of breastfeeding should be considered along with the mother’s clinical need for SYNDROS and any potential adverse effects on the breastfed infant from SYNDROS or from the underlying maternal condition.[L43438] The safety and effectiveness of SYNDROS have not been established in pediatric patients. Pediatric patients may be more sensitive to the neurological and psychoactive effects of SYNDROS. SYNDROS contains the excipients 50% (w/w) dehydrated alcohol and 5.5% (w/w) propylene glycol. Ethanol competitively inhibits the metabolism of propylene glycol, which may lead to elevated concentrations of propylene glycol. Preterm neonates may be at increased risk of propylene glycol-associated adverse events due to diminished ability to metabolize propylene glycol, thereby, leading to accumulation.[L43438] Clinical studies of dronabinol capsules in AIDS and cancer patients did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. Elderly patients may be more sensitive to the neuropsychiatric and postural hypotensive effects of SYNDROS. Elderly patients with dementia are at increased risk for falls as a result of their underlying disease state, which may be exacerbated by the CNS effects of somnolence and dizziness associated with SYNDROS. These patients should be monitored closely and placed on fall precautions prior to initiating SYNDROS therapy. In antiemetic studies, no difference in efficacy was apparent in patients greater than 55 years of age compared to younger patients. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of falls decreased hepatic, renal, or cardiac function, increased sensitivity to psychoactive effects, and concomitant disease or other drugs therapy.[L43438] SYNDROS contains dronabinol, the main psychoactive component in marijuana. Ingestion of high doses of dronabinol increases the risk of psychiatric adverse reactions if abused or misused, while continued administration can lead to addiction. Psychiatric adverse reactions may include psychosis, hallucinations, depersonalization, mood alteration, and paranoia. In vitro studies demonstrate that SYNDROS can be easily and effectively abused without manipulation. SYNDROS contains 50% (w/w) dehydrated alcohol. In a randomized, single-dose, double-blind, placebo- and active-controlled crossover pharmacodynamic study of 43 experienced marijuana smokers, “drug liking” responses and safety of SYNDROS were compared with placebo and dronabinol in sesame oil oral capsules. Treatment arms were 10 mg and 30 mg dronabinol capsules, 10 mg and 30 mg dronabinol from= SYNDROS, and placebo oral solution and capsules. Greater “drug liking” scores were reported with the 30 mg dose, compared with the 10 mg dose, for both SYNDROS and dronabinol-containing capsules. Overall, the pharmacodynamic results from this study demonstrated no statistically significant differences in various measures of drug liking for the doses taken, though the SYNDROS results were consistently greater than those of dronabinol capsules. Similarly, observed adverse reactions were greater for SYNDROS. The pharmacodynamic and safety effects of SYNDROS following multiple doses have not been evaluated. Patients should be instructed to keep SYNDROS in a secure place out of reach of others for whom the medication has not been prescribed.[L43438] Physical dependence is a state that develops as a result of physiological adaptation in response to repeated drug use. Physical dependence manifests by drug class-specific withdrawal symptoms after abrupt discontinuation or a significant dose reduction of a drug. The appearance of a withdrawal syndrome when the administration of the drug is terminated is the only actual evidence of physical dependence. Physical dependence can develop during chronic therapy with SYNDROS and develops after chronic abuse of marijuana. A withdrawal syndrome was reported after the abrupt discontinuation of dronabinol capsules in subjects receiving dosages of 210 mg per day for 12 to 16 consecutive days. Within 12 hours after discontinuation, subjects manifested symptoms such as irritability, insomnia, and restlessness. By approximately 24 hours post-dronabinol discontinuation, withdrawal symptoms intensified to include “hot flashes”, sweating, rhinorrhea, loose stools, hiccoughs, and anorexia. These withdrawal symptoms gradually dissipated over the next 48 hours. Electroencephalographic changes consistent with the effects of drug withdrawal (hyperexcitation) were recorded in patients after abrupt dechallenge. Patients also complained of disturbed sleep for several weeks after discontinuing therapy with high dosages of dronabinol.[L43438] Signs and symptoms of dronabinol overdose include drowsiness, euphoria, heightened sensory awareness, altered time perception, reddened conjunctiva, dry mouth, tachycardia, memory impairment, depersonalization, mood alteration, urinary retention, reduced bowel motility, decreased motor coordination, lethargy, slurred speech, and postural hypotension. Patients may also experience panic reactions if they have a prior history of nervousness or anxiety and seizures may occur in patients with existing seizure disorders. It is not known if dronabinol can be removed by dialysis in cases of overdose.[L43438]	The elimination phase of dronabinol can be described using a two-compartment model with an initial (alpha) half-life of about 4 hours and a terminal (beta) half-life of 25 to 36 hours.[L43438]	The plasma protein binding of dronabinol and its metabolites is approximately 97%.[L43438]	Dronabinol and its biotransformation products are excreted in both feces and urine. Biliary excretion is the major route of excretion with about half of a radiolabeled oral dose being recovered from the feces within 72 hours as contrasted with 10 to 15% recovered from urine. Less than 5% of an oral dose is recovered unchanged in the feces.[L43438] Due to its redistribution, dronabinol and its metabolites may be excreted for prolonged periods of time. Following single-dose administration, dronabinol metabolites have been detected for more than 5 weeks in the urine and feces.[L43438] In a study of dronabinol capsules involving AIDS patients, urinary cannabinoid/creatinine concentration ratios were studied bi-weekly over a six-week period. The urinary cannabinoid/creatinine ratio was closely correlated with the dose. No increase in the cannabinoid/creatinine ratio was observed after the first two weeks of treatment, indicating that steady-state cannabinoid levels had been reached. This conclusion is consistent with predictions based on the observed terminal half-life of dronabinol.[L43438]	Dronabinol has a large apparent volume of distribution, approximately 10 L/kg, because of its lipid solubility.[L43438]	The value for clearance average is about 0.2 L/kg-hr but is highly variable due to the complexity of cannabinoid distribution.[L43438]	Organic compounds	Organoheterocyclic compounds	Benzopyrans	1-benzopyrans	[ "approved", "illicit" ]	[ "A04AD", "A04A", "A04", "A" ]	[ "Humans and other mammals" ]	[ { "cost": "5.11", "description": "Dronabinol 2.5 mg capsule", "unit": "capsule" }, { "cost": "8.02", "description": "Marinol 2.5 mg capsule", "unit": "capsule" }, { "cost": "11.8", "description": "Dronabinol 5 mg capsule", "unit": "capsule" }, { "cost": "16.0", "description": "Marinol 5 mg capsule", "unit": "capsule" }, { "cost": "19.26", "description": "Dronabinol 10 mg capsule", "unit": "capsule" }, { "cost": "29.86", "description": "Marinol 10 mg capsule", "unit": "capsule" } ]	[ { "approved": "2004-03-09", "country": "United States", "expires": "2011-02-26", "number": "6703418" }, { "approved": "2012-07-17", "country": "United States", "expires": "2028-08-06", "number": "8222292" }, { "approved": "2016-05-24", "country": "United States", "expires": "2028-08-06", "number": "9345771" }, { "approved": "2019-04-23", "country": "United States", "expires": "2028-08-06", "number": "10265293" }, { "approved": "2008-08-06", "country": "United States", "expires": "2028-08-06", "number": "11253472" } ]	.DELTA.1-THC \| (-)-delta9-trans-Tetrahydrocannabinol \| 1-trans-delta-9-Tetrahydrocannabinol \| 3-Pentyl-6,6,9-trimethyl-6a,7,8,10a-tetrahydro-6H-dibenzo(b,d)pyran-1-ol \| 6,6,9-Trimethyl-3-pentyl-6a,7,8,10a-tetrahydro-6H-benzo[c]chromen-1-ol \| delta-9-tetrahydrocannabinol \| delta-9-THC \| delta(1)-tetrahydrocannabinol \| delta(9)-THC \| delta9-tetrahydrocannabinol \| Dronabinol \| Dronabinolum \| Tetrahydrocannabinol \| THC \| Δ9-tetrahydrocannabinol \| CANN6 \| CB-R \| CB1 \| CNR \| CB-2 \| CB2 \| CB2A \| CB2B \| CX5 \| hCB2 \| 1.14.14.1 \| CYPIA1 \| Cytochrome P450 form 6 \| Cytochrome P450-C \| Cytochrome P450-P1 \| Hydroperoxy icosatetraenoate dehydratase \| 1.14.14.1 \| Cholesterol 25-hydroxylase \| CYPIA2 \| Cytochrome P(3)450 \| Cytochrome P450 4 \| Cytochrome P450-P3 \| Hydroperoxy icosatetraenoate dehydratase \| 1.14.14.1 \| CYPIB1 \| Hydroperoxy icosatetraenoate dehydratase \| 1,4-cineole 2-exo-monooxygenase \| 1.14.14.- \| Coumarin 7-hydroxylase \| CYP2A3 \| CYPIIA6 \| Cytochrome P450 IIA3 \| Cytochrome P450(I) \| (R)-limonene 6-monooxygenase \| (S)-limonene 6-monooxygenase \| (S)-limonene 7-monooxygenase \| 1.14.14.1 \| Cholesterol 25-hydroxylase \| CYP2C10 \| CYPIIC9 \| Cytochrome P-450MP \| Cytochrome P450 MP-4 \| Cytochrome P450 MP-8 \| Cytochrome P450 PB-1 \| S-mephenytoin 4-hydroxylase \| 1,4-cineole 2-exo-monooxygenase \| 1.14.13.- \| CYPIIB6 \| Cytochrome P450 IIB1 \| (R)-limonene 6-monooxygenase \| (S)-limonene 6-monooxygenase \| (S)-limonene 7-monooxygenase \| 1.14.14.1 \| CYPIIC17 \| CYPIIC19 \| Cytochrome P450-11A \| Cytochrome P450-254C \| Fenbendazole monooxygenase (4'-hydroxylating) \| Mephenytoin 4-hydroxylase \| 1.14.14.- \| Cholesterol 25-hydroxylase \| CYP2DL1 \| CYPIID6 \| Cytochrome P450-DB1 \| Debrisoquine 4-hydroxylase \| 1.14.14.- \| Albendazole monooxygenase (hydroxylating) \| Albendazole monooxygenase (sulfoxide-forming) \| Arachidonic acid epoxygenase \| CYPIIJ2 \| Hydroperoxy icosatetraenoate isomerase \| 1,4-cineole 2-exo-monooxygenase \| 1,8-cineole 2-exo-monooxygenase \| 1.14.14.1 \| Albendazole monooxygenase (sulfoxide-forming) \| Albendazole sulfoxidase \| Cholesterol 25-hydroxylase \| CYP3A3 \| CYPIIIA3 \| CYPIIIA4 \| Cytochrome P450 3A3 \| Cytochrome P450 HLp \| Cytochrome P450 NF-25 \| Cytochrome P450-PCN1 \| Nifedipine oxidase \| Quinine 3-monooxygenase \| 1.14.14.1 \| CYPIIIA5 \| Cytochrome P450-PCN3 \| 1.14.14.1 \| CYPIIIA7 \| Cytochrome P450-HFLA \| P450HLp2 \| ACAT \| Acyl-coenzyme A:cholesterol acyltransferase \| Brain carboxylesterase hBr1 \| Carboxylesterase 1 \| CE-1 \| CEH \| CES2 \| Cholesteryl ester hydrolase \| Cocaine carboxylesterase \| Egasyn \| hCE-1 \| HMSE \| Methylumbelliferyl-acetate deacetylase 1 \| Monocyte/macrophage serine esterase \| REH \| Retinyl ester hydrolase \| Serine esterase 1 \| SES1 \| TGH \| Triacylglycerol hydrolase \| 1.14.99.1 \| COX-1 \| COX1 \| Cyclooxygenase-1 \| PGH synthase 1 \| PGHS-1 \| PHS 1 \| Prostaglandin H2 synthase 1 \| Prostaglandin-endoperoxide synthase 1 \| 2.4.1.17 \| Bilirubin-specific UDPGT isozyme 1 \| GNT1 \| hUG-BR1 \| UDP-glucuronosyltransferase 1-1 \| UDP-glucuronosyltransferase 1A isoform 1 \| UDPGT 1-1 \| UGT1 \| UGT1-01 \| UGT1.1 \| UGT11 \| UGT1A1 \| 2.4.1.17 \| GNT1 \| UDP-glucuronosyltransferase 1-3 \| UDP-glucuronosyltransferase 1-C \| UDP-glucuronosyltransferase 1A isoform 3 \| UDPGT 1-3 \| UGT-1C \| UGT1 \| UGT1-03 \| UGT1.3 \| UGT13 \| UGT1A3 \| UGT1C \| 2.4.1.17 \| GNT1 \| lugP4 \| UDP-glucuronosyltransferase 1-9 \| UDP-glucuronosyltransferase 1-I \| UDPGT 1-9 \| UGT-1I \| UGT1 \| UGT1-09 \| UGT1.9 \| UGT19 \| UGT1A9 \| UGT1I \| 2.4.1.17 \| GNT1 \| UDP-glucuronosyltransferase 1-10 \| UDP-glucuronosyltransferase 1-J \| UDPGT 1-10 \| UGT-1J \| UGT1 \| UGT1-10 \| UGT1.10 \| UGT110 \| UGT1A10 \| UGT1J \| 7.6.2.2 \| ABCP \| ATP-binding cassette sub-family G member 2 \| BCRP \| BCRP1 \| Breast cancer resistance protein \| CDw338 \| Mitoxantrone resistance-associated protein \| MXR \| Placenta-specific ATP-binding cassette transporter \| Urate exporter \| ATP-binding cassette sub-family B member 1 \| MDR1 \| Multidrug resistance protein 1 \| P-glycoprotein 1 \| PGY1 \| Phospholipid transporter ABCB1 \| 7.6.2.2 \| ATP-binding cassette sub-family C member 1 \| Glutathione-S-conjugate-translocating ATPase ABCC1 \| Leukotriene C(4) transporter \| LTC4 transporter \| MRP \| MRP1	[ "Dronabinol", "Dronabinol", "Dronabinol", "Dronabinol", "Dronabinol", "Dronabinol", "Dronabinol", "Dronabinol", "Dronabinol", "Dronabinol", "Dronabinol", "Dronabinol", "Dronabinol", "Dronabinol", "Dronabinol", "Dronabinol", "Dronabinol", "Dronabinol", "Dronabinol", "Dronabinol", "Dronabinol", "Dronabinol", "Dronabinol", "Dronabinol", "Dronabinol", "Dronabinol", "Dronabinol", "Dronabinol", "Dronabinol", "Dronabinol", "Dronabinol", "Dronabinol", "Dronabinol", "Dronabinol", "Dronabinol", "Dronabinol", "Dronabinol", "Dronabinol", "Dronabinol", "Dronabinol", "Dronabinol", "Dronabinol", "Dronabinol", "Dronabinol", "Dronabinol", "Dronabinol", "Dronabinol", "Dronabinol", "Dronabinol", "Marinol", "Marinol", "Marinol", "Marinol", "Marinol", "Marinol", "Marinol", "Marinol", "Marinol", "Marinol", "Marinol", "Marinol", "Marinol", "Marinol Cap 10mg", "Sativex", "Syndros", "Syndros" ]	[]	[ "Sativex" ]	[ "P21554", "P34972" ]	[ "P04798", "P05177", "Q16678", "P11509", "P11712", "P20813", "P33261", "P10635", "P51589", "P08684", "P20815", "P24462", "P23141", "P23219", "P22309", "P35503", "O60656", "Q9HAW8" ]	[]	[ "Q9UNQ0", "P08183", "P33527" ]
DB00471	Montelukast	Montelukast was first approved for clinical use by the US FDA in 1998 as Merck's brand name Singulair.[L6301] The medication is a member of the leukotriene receptor antagonist (LTRA) category of drugs.[L6301,L6304,L6307,L6310,L6325,L6328,L6331] Although capable of demonstrating effectiveness, the use of such LTRAs like montelukast is typically in addition to or complementary with the use of inhaled corticosteroids or other agents in asthma step therapy.[A178645] Regardless, in 2008-2009, there were FDA-led investigations into the possibility of montelukast to elicit neuropsychiatric effects like agitation, hallucinations, suicidal behaviour, and others in individuals who used the medication.[A178651] And although these kinds of effects are currently included in the official prescribing information for montelukast,[L6301,L6304,L6307,L6310,L6325,L6328,L6331] the drug still sees extensive use worldwide via millions of prescriptions annually and has since become available as a generic and as a brand name product.	solid	Montelukast is indicated for: (a) the prophylaxis and chronic treatment of asthma in adults and pediatric patients who are 12 months of age and older[L6301], although other regional health authorities specifically note this indication for adults and adolescents who are 15 years and older[L6304,L6307] and also include indications for preventing day and night-time symptoms, and the treatment of acetylsalicylic acid-sensitive asthma[L6304]; (b) the prevention of exercise-induced bronchoconstriction (EIB) in patients who are 6 years of age and older[L6301], although other regional health authorities specifically note this indication for adults and adolescents who are 15 years and older[L6304,L6307]; and (c) the relief of symptoms of seasonal allergic rhinitis in patients 2 years of age and older and perennial allergic rhinitis in patients 6 months of age and older[L6301], although other regional health authorities specifically note the relief of seasonal allergic rhinitis symptoms for adults and adolescents who are 15 years and older[L6304,L6307]. Furthermore, some formulations like chewable montelukast tablets may also be specifically indicated by particular regulatory bodies for the prophylaxis and chronic treatment of asthma, including the prevention of day and night-time symptoms, the treatment of acetylsalicylic acid based asthma, and the prevention of exercise-induced bronchoconstriction in adult and pediatric patients aged 2 and older[L6328], between the ages 2 and 5[L6325], or between the ages of 6 and 14 years.[L6331] Moreover, when employed for such indications montelukast is considered effective as monotherapy or when combined with other medications indicated for the maintenance treatment of chronic asthma.[L6304,L6328] For instance, montelukast and inhaled corticosteroids can be used concomitantly to demonstrate additive effects to control asthma or to decrease the necessary inhaled corticosteroid dose while still maintaining clinical stability.[L6304,L6328] Additionally, in patients who continue to experience asthma symptoms, montelukast can also be combined with an 'as required' short-acting beta-agonist, an inhaled corticosteroid, or inhaled corticosteroid paired with a long-acting beta-agonist.[L6304,L6328]	Montelukast is a leukotriene receptor antagonist that demonstrates a marked affinity and selectivity to the cysteinyl leukotriene receptor type-1 in preference to many other crucial airway receptors like the prostanoid, cholinergic, or beta-adrenergic receptors.[L6301,L6304,L6307,L6310,L6325,L6328,L6331] As a consequence, the agent can elicit substantial blockage of LTD4 leukotriene-mediated bronchoconstriction with doses as low as 5 mg.[L6301,L6304,L6307,L6310,L6325,L6328,L6331] Moreover, a placebo-controlled, crossover study (n=12) demonstrated that montelukast is capable of inhibiting early and late phase bronchoconstriction caused by antigen challenge by 75% and 57% respectively.[L6301,L6304,L6307,L6310,L6325,L6328,L6331] In particular, it has been documented that montelukast can cause bronchodilation as soon as within 2 hours of oral administration.[L6301,L6304,L6307,L6310,L6325,L6328,L6331] This action can also be additive to the bronchodilation caused by the concomitant use of a beta agonist.[L6301,L6304,L6307,L6310,L6325,L6328,L6331] Nevertheless, clinical investigations performed with adults 15 years of age and older revealed that no additional clinical benefit is obtained when doses of montelukast greater than 10 mg a day are used.[L6301,L6304,L6307,L6310,L6325,L6328,L6331] Additionally, in clinical trials with adults and pediatric asthmatic patients aged 6 to 14 years, it was also determined that montelukast can reduce mean peripheral blood eosinophils by about 13% to 15% from baseline in comparison to placebo during double-blind treatment periods.[L6301,L6304,L6307,L6310,L6325,L6328,L6331] At the same time, in patients aged 15 years and older who were experiencing seasonal allergic rhinitis, the use of montelukast caused a median reduction of 13% in peripheral blood eosinophil counts when compared to placebo as well.[L6301,L6304,L6307,L6310,L6325,L6328,L6331]	Cysteinyl leukotrienes (CysLT) like LTC4, LTD4, and LTE4, among others, are eicosanoids released by a variety of cells like mast cells and eosinophils.[L6301,L6304,L6307,L6310,L6325,L6328,L6331] When such CysLT bind to corresponding CysLT receptors like CysLT type-1 receptors located on respiratory airway smooth muscle cells, airway macrophages, and on various pro-inflammatory cells like eosinophils and some specific myeloid stem cells activities that facilitate the pathophysiology of asthma and allergic rhinitis are stimulated.[L6301,L6304,L6307,L6310,L6325,L6328,L6331] In particular, CysLT-mediated airway bronchoconstriction, occluding mucous secretion, vascular permeability, and eosinophil recruitment are all types of effects that facilitate asthma.[L6301,L6304,L6307,L6310,L6325,L6328,L6331] Alternatively, in allergic rhinitis, CysLTs are released by the nasal mucosa when exposed to allergens during both early and late phase reactions and participate in eliciting symptoms of allergic rhinitis like a congested nose and airway.[L6301,L6304,L6307,L6310,L6325,L6328,L6331] Subsequently, montelukast is a leukotriene receptor antagonist that binds with high affinity and selectivity to the CysLT type 1 receptor, which consequently assists in inhibiting any physiological actions of CysLTs like LTC4, LTD4, and LTE4 at the receptor that may facilitate asthma or allergic rhinitis.[L6301,L6304,L6307,L6310,L6325,L6328,L6331]	It has been observed that montelukast is quickly absorbed following administration by the oral route.[L6301,L6304,L6307,L6310,L6325,L6328,L6331] The oral bioavailability documented for the drug is 64%.[L6301,L6304,L6307,L6310,L6325,L6328,L6331] Furthermore, it seems that having a regular meal in the morning or even a high fat snack in the evening does not affect the absorption of montelukast.[L6301,L6304,L6307,L6310,L6325,L6328,L6331]	It has been determined that montelukast is highly metabolized and typically so by the cytochrome P450 3A4, 2C8, and 2C9 isoenzymes.[L6301,L6304,L6307,L6310,L6325,L6328,L6331] In particular, it seems that the CYP2C8 enzymes play a significant role in the metabolism of the drug.[L6301,L6304,L6307,L6310,L6325,L6328,L6331] Nevertheless, at therapeutic doses, the plasma concentrations of montelukast metabolites are undetectable at steady state in adults and pediatric patients.[L6301,L6304,L6307,L6310,L6325,L6328,L6331]	The adverse effects associated with overdosage of montelukast include abdominal pain, somnolence, thirst, headache, vomiting, psychomotor hyperactivity, and less frequently, convulsion.[L6301,L6304,L6307,L6310,L6325,L6328,L6331] The oral LD50 value determined for mice and rats is >5000 mg/kg.[L6301,L6304,L6307,L6310,L6325,L6328,L6331] Montelukast has not been studied in pregnant women.[L6301,L6304,L6307,L6310,L6325,L6328,L6331] Consequently, it should be used during pregnancy only if clearly needed.[L6301,L6304,L6307,L6310,L6325,L6328,L6331] Additionally, as it is unknown whether montelukast is excreted into human breast milk, there is also caution regarding the use of the medication in nursing mothers.[L6301,L6304,L6307,L6310,L6325,L6328,L6331] The plasma half-life of montelukast is somewhat prolonged in elderly patients, although no dosage adjustment is generally necessary.[L6301,L6304,L6307,L6310,L6325,L6328,L6331]	Studies have demonstrated that the mean plasma half-life of montelukast varies from 2.7 to 5.5 hours when observed in healthy young adults.[L6301,L6304,L6307,L6325,L6328,L6331]	It has been determined that the protein binding of montelukast to plasma proteins exceeds 99%.[L6301,L6304,L6307,L6325,L6328,L6331]	It has been reported that montelukast and its metabolites are almost exclusively excreted in the bile and into the feces.[L6301,L6304,L6307,L6310,L6325,L6328,L6331]	The steady-state volume of distribution recorded for montelukast is an average between 8 to 11 litres.[L6301,L6304,L6307,L6325,L6328,L6331]	The plasma clearance documented for montelukast is an average of 45 mL/min when observed in healthy adults.[L6301,L6304,L6307,L6325,L6328,L6331]	Organic compounds	Phenylpropanoids and polyketides	Linear 1,3-diarylpropanoids	null	[ "approved" ]	[ "R03DC", "R03D", "R03", "R", "R03DC", "R03D", "R03", "R" ]	[ "Humans and other mammals" ]	[ { "cost": "4.77", "description": "Singulair 10 mg tablet", "unit": "tablet" }, { "cost": "145.91", "description": "Singulair 30 4 mg Chew Tabs Bottle", "unit": "bottle" }, { "cost": "145.91", "description": "Singulair 30 4 mg Packets Packet", "unit": "packet" }, { "cost": "145.91", "description": "Singulair 30 5 mg Chew Tabs Bottle", "unit": "bottle" } ]	[ { "approved": "2009-03-17", "country": "Canada", "expires": "2014-12-22", "number": "2179407" }, { "approved": "1998-12-08", "country": "Canada", "expires": "2011-10-10", "number": "2053209" }, { "approved": "2011-08-30", "country": "United States", "expires": "2022-10-24", "number": "8007830" } ]	(R-(E))-1-(((1-(3-(2-(7-Chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropaneacetic acid \| 1-[[[(1 R)-1-[3-[(1E)-2-(7-chloro-2-quinolinyl)ethenyl] phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]sulfanyl]methyl]cyclopropaneacetic acid \| Montelukast \| Montélukast \| Montelukastum \| CYSLT1 \| CysLTR1 \| Cysteinyl leukotriene D4 receptor \| G-protein coupled receptor HG55 \| HMTMF81 \| LTD4 receptor \| 1.13.11.- \| 5-lipoxygenase \| 5-LO \| Arachidonate 5-lipoxygenase \| LOG5 \| 1.14.99.1 \| COX-1 \| COX1 \| Cyclooxygenase-1 \| PGH synthase 1 \| PGHS-1 \| PHS 1 \| Prostaglandin H2 synthase 1 \| Prostaglandin-endoperoxide synthase 1 \| 1,4-cineole 2-exo-monooxygenase \| 1.14.14.- \| Coumarin 7-hydroxylase \| CYP2A3 \| CYPIIA6 \| Cytochrome P450 IIA3 \| Cytochrome P450(I) \| 1,4-cineole 2-exo-monooxygenase \| 1,8-cineole 2-exo-monooxygenase \| 1.14.14.1 \| Albendazole monooxygenase (sulfoxide-forming) \| Albendazole sulfoxidase \| Cholesterol 25-hydroxylase \| CYP3A3 \| CYPIIIA3 \| CYPIIIA4 \| Cytochrome P450 3A3 \| Cytochrome P450 HLp \| Cytochrome P450 NF-25 \| Cytochrome P450-PCN1 \| Nifedipine oxidase \| Quinine 3-monooxygenase \| (R)-limonene 6-monooxygenase \| (S)-limonene 6-monooxygenase \| (S)-limonene 7-monooxygenase \| 1.14.14.1 \| Cholesterol 25-hydroxylase \| CYP2C10 \| CYPIIC9 \| Cytochrome P-450MP \| Cytochrome P450 MP-4 \| Cytochrome P450 MP-8 \| Cytochrome P450 PB-1 \| S-mephenytoin 4-hydroxylase \| 1.14.14.1 \| CYPIIC8 \| Cytochrome P450 form 1 \| Cytochrome P450 IIC2 \| Cytochrome P450 MP-12 \| Cytochrome P450 MP-20 \| S-mephenytoin 4-hydroxylase \| KIAA0880 \| OATP-B \| OATP-RP2 \| OATP2B1 \| OATPB \| OATPRP2 \| Organic anion transporter B \| Organic anion transporter polypeptide-related protein 2 \| Organic anion transporting polypeptide 2B1 \| SLC21A9 \| Solute carrier family 21 member 9	[ "Accel-montelukast Sodium Tablets", "Ach-montelukast", "Ach-montelukast", "Ach-montelukast", "Ag-montelukast", "Ag-montelukast", "Ag-montelukast", "Apo-montelukast", "Apo-montelukast", "Apo-montelukast", "Apo-montelukast Sodium", "Apo-montelukast Sodium Chewable", "Apo-montelukast Sodium Chewable", "Auro-montelukast", "Auro-montelukast Chewable Tablet", "Auro-montelukast Chewable Tablet", "Bio-montelukast", "Dom-montelukast", "Dom-montelukast", "Dom-montelukast Fc", "Ipg-montelukast", "Ipg-montelukast", "Ipg-montelukast", "Jamp Montelukast Chewable Tablets", "Jamp Montelukast Chewable Tablets", "Jamp-montelukast", "Jamp-montelukast", "Jamp-montelukast", "M-montelukast", "M-montelukast", "M-montelukast", "M-montelukast", "M-montelukast", "Mar-montelukast", "Mar-montelukast", "Mar-montelukast", "Mint-montelukast", "Mint-montelukast", "Mint-montelukast", "Montelukast", "Montelukast", "Montelukast", "Montelukast", "Montelukast", "Montelukast", "Montelukast", "Montelukast", "Montelukast", "Montelukast", "Montelukast", "Montelukast", "Montelukast", "Montelukast", "Montelukast", "Montelukast", "Montelukast", "Montelukast", "Montelukast", "Montelukast", "Montelukast", "Montelukast", "Montelukast", "Montelukast", "Montelukast", "Montelukast", "Montelukast", "Montelukast", "Montelukast", "Montelukast", "Montelukast", "Montelukast", "Montelukast", "Montelukast", "Montelukast", "Montelukast", "Montelukast", "Montelukast", "Montelukast", "Montelukast", "Montelukast", "Montelukast", "Montelukast", "Montelukast", "Montelukast", "Montelukast", "Montelukast", "Montelukast", "Montelukast", "Montelukast", "Montelukast", "Montelukast", "Montelukast", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast sodium", "Montelukast sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast Sodium", "Montelukast sodium chewable", "Montelukast sodium chewable", "Mylan-montelukast", "Mylan-montelukast", "Mylan-montelukast", "Nat-montelukast", "Nat-montelukast", "Nat-montelukast", "Nra-montelukast", "Nra-montelukast", "Nra-montelukast", "Ntp-montelukast", "Ntp-montelukast", "Ntp-montelukast", "Pendo-montelukast", "Pendo-montelukast", "Pendo-montelukast Fc", "PMS-montelukast", "PMS-montelukast", "PMS-montelukast Fc", "Priva-montelukast", "Q-montelukast", "Ran-montelukast", "Ran-montelukast", "Ratio-montelukast", "Ratio-montelukast", "Ratio-montelukast", "Riva-montelukast", "Riva-montelukast", "Riva-montelukast Fc", "Sandoz Montelukast", "Sandoz Montelukast", "Sandoz Montelukast", "Sandoz Montelukast", "Singulair", "Singulair", "Singulair", "Singulair", "Singulair", "Singulair", "Singulair", "Singulair", "Singulair", "Singulair", "Singulair", "Singulair", "Singulair", "Singulair", "Singulair", "Singulair", "Singulair", "Singulair", "Singulair", "Singulair", "Singulair", "Singulair", "Singulair", "Singulair", "Singulair", "Singulair", "Singulair", "Singulair", "Singulair", "Singulair", "Singulair", "Singulair", "Singulair", "Singulair", "Singulair", "Singulair", "Singulair", "Singulair", "Taro-montelukast", "Teva-montelukast", "Teva-montelukast", "Teva-montelukast", "Uni-montelukast", "Uni-montelukast", "Uni-montelukast", "Van-montelukast", "Van-montelukast", "Van-montelukast" ]	[ "Lukotas", "Molly", "Monocast", "Monteflo", "Montelo-10", "Montene", "Respaire", "Surfair", "Telumantes", "Ventek", "Ventilar", "Xalar", "Zespira" ]	[]	[ "Q9Y271", "P09917" ]	[ "P23219", "P11509", "P08684", "P11712", "P10632" ]	[]	[ "O94956" ]
DB00473	Hexylcaine	Hexylcaine hydrochloride is also known as cyclaine and osmocaine. It is a short acting local anesthetic that acts through inhibition of sodium channels. Patients experience an overdose may present with headache, tinnitus, numbness and tingling around the mouth and tongue, convulsions, inability to breathe, and decreased heart function. Hexylcaine has been discontinued in the US market.	solid	Used as a local anesthetic for surface application, infiltration or nerve block	Hexylcaine is a local ester-class anesthetic. Local anesthetics produce a transient block of nerve conduction by interfering with sodium channels. This effect of the anesthetic interferes with the development of an action potential across the nerve.	Hexyl caine acts mainly by inhibiting sodium influx through voltage gated sodium channels in the neuronal cell membrane of peripheral nerves. When the influx of sodium is interrupted, an action potential cannot arise and signal conduction is thus inhibited. The receptor site is thought to be located at the cytoplasmic (inner) portion of the sodium channel.	null	Hydrolyzed by plasma esterases to benzoic acid and other derivatives	Symptoms of anesthetic overdose include headache, tinnitus, circumoral and tongue paresthesias, restlessness, talkativeness, facial twitching, convulsions, respiratory arrest, and cardiac depression	<10 minutes	null	null	null	null	Organic compounds	Benzenoids	Benzene and substituted derivatives	Benzoic acids and derivatives	[ "approved", "withdrawn" ]	[]	[ "Humans and other mammals" ]	[]	[]	Hexilcaina \| Hexylcaine \| Hexylcainum \| hH1 \| Sodium channel protein cardiac muscle subunit alpha \| Sodium channel protein type V subunit alpha \| Voltage-gated sodium channel subunit alpha Nav1.5 \| hPN3 \| Peripheral nerve sodium channel 3 \| PN3 \| Sodium channel protein type X subunit alpha \| Voltage-gated sodium channel subunit alpha Nav1.8	[]	[ "Cyclaine" ]	[]	[ "Q14524", "Q9Y5Y9" ]	[]	[]	[]
DB00474	Methohexital	An intravenous anesthetic with a short duration of action that may be used for induction of anesthesia.	solid	Methohexital is indicated for use as an intravenous anaesthetic. It has also been commonly used to induce deep sedation.	Methohexital, a barbiturate, is used for the induction of anesthesia prior to the use of other general anesthetic agents and for induction of anesthesia for short surgical, diagnostic, or therapeutic procedures associated with minimal painful stimuli. Little analgesia is conferred by barbiturates; their use in the presence of pain may result in excitation.	Methohexital binds at a distinct binding site associated with a Cl<sup>-</sup> ionopore at the GABA<sub>A</sub> receptor, increasing the duration of time for which the Cl<sup>-</sup> ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged.	The absolute bioavailability following rectal administration of methohexital is 17%.	Metabolism occurs in the liver through demethylation and oxidation. Side-chain oxidation is the most important biotransformation involved in termination of biologic activity.	The onset of toxicity following an overdose of intravenously administered methohexital will be within seconds of the infusion. If methohexital is administered rectally or is ingested, the onset of toxicity may be delayed. The manifestations of an ultrashort-acting barbiturate in overdose include central nervous system depression, respiratory depression, hypotension, loss of peripheral vascular resistance, and muscular hyperactivity ranging from twitching to convulsive-like movements. Other findings may include convulsions and allergic reactions. Following massive exposure to any barbiturate, pulmonary edema, circulatory collapse with loss of peripheral vascular tone, and cardiac arrest may occur.	5.6 ± 2.7 minutes	73%	Excretion occurs via the kidneys through glomerular filtration.	null	null	Organic compounds	Organoheterocyclic compounds	Diazines	Pyrimidines and pyrimidine derivatives	[ "approved" ]	[ "N05CB", "N05C", "N05", "N", "N01AF", "N01A", "N01", "N", "N05CA", "N05C", "N05", "N" ]	[ "Humans and other mammals" ]	[ { "cost": "221.2", "description": "Brevital sodium 2.5 gm vial", "unit": "vial" } ]	[]	(±)-5-allyl-1-methyl-5-(1-methyl-2-pentynyl)barbituric acid \| 5-allyl-1-methyl-5-(1-methyl-2-pentynyl)-2,4,6(1H,3H,5H)-pyrimidinetrione \| 5-Allyl-1-methyl-5-(1-methyl-pent-2-ynyl)-pyrimidine-2,4,6-trione \| 5-Allyl-5-(3-hexyn-2-yl)-1-methylbarbituric acid \| Methohexital \| Methohexitalum \| Methohexitone \| Metohexital \| α-DL-1-methyl-5-allyl-5-(1'-methylpentyn-2-yl)barbituric acid \| GABA(A) receptor subunit alpha-1 \| GABAAR subunit alpha-1	[ "Brevital Sodium", "Brevital Sodium", "Brevital Sodium", "Brevital Sodium", "Brevital Sodium", "Brevital Sodium", "Brevital Sodium", "Brietal Sodium Ampoule 660", "Methohexital Sodium", "Methohexital Sodium" ]	[ "Brevital", "Brietal" ]	[]	[ "P14867" ]	[]	[]	[]
DB00475	Chlordiazepoxide	An anxiolytic benzodiazepine derivative with anticonvulsant, sedative, and amnesic properties. It has also been used in the symptomatic treatment of alcohol withdrawal.	solid	Chlordiazepoxide is indicated for the management of anxiety disorders or for the short-term relief of symptoms of anxiety, withdrawal symptoms of acute alcoholism, and preoperative apprehension and anxiety.[L37934] In combination with amitriptyline, chlordiazepoxide is indicated for the treatment of moderate to severe depression.[L44898] In combination with clidinium, chlordiazepoxide is indicated to control emotional and somatic factors in gastrointestinal disorders, and is used as adjunctive therapy in the treatment of peptic ulcer, irritable bowel syndrome and acute enterocolitis.[L44893]	Chlordiazepoxide has antianxiety, sedative, appetite-stimulating and weak analgesic actions. The drug seems to block EEG arousal from stimulation in the brain stem reticular formation. The drug has been studied extensively in many species of animals and these studies are suggestive of action on the limbic system of the brain, which recent evidence indicates is involved in emotional responses. Hostile monkeys were made tame by oral drug doses which did not cause sedation. Chlordiazepoxide revealed a "taming" action with the elimination of fear and aggression. The taming effect of chlordiazepoxide was further demonstrated in rats made vicious by lesions in the septal area of the brain. The drug dosage which effectively blocked the vicious reaction was well below the dose which caused sedation in these animals.	Chlordiazepoxide binds to stereospecific benzodiazepine (BZD) binding sites on GABA (A) receptor complexes at several sites within the central nervous system, including the limbic system and reticular formation. This results in an increased binding of the inhibitory neurotransmitter GABA to the GABA(A) receptor. BZDs, therefore, enhance GABA-mediated chloride influx through GABA receptor channels, causing membrane hyperpolarization. The net neuro-inhibitory effects result in the observed sedative, hypnotic, anxiolytic, and muscle relaxant properties.	null	Hepatic.	LD<sub>50</sub>=537 mg/kg (Orally in rats). Signs of overdose include respiratory depression, muscle weakness, somnolence (general depressed activity).	24-48 hours	null	Chlordiazepoxide is excreted in the urine, with 1% to 2% unchanged and 3% to 6% as conjugate.	null	null	Organic compounds	Organoheterocyclic compounds	Benzodiazepines	1,4-benzodiazepines	[ "approved", "illicit", "investigational" ]	[ "N05BA", "N05B", "N05", "N" ]	[ "Humans and other mammals" ]	[ { "cost": "1.61", "description": "Librium 10 mg capsule", "unit": "capsule" }, { "cost": "1.93", "description": "Limbitrol DS 10-25 mg tablet", "unit": "tablet" }, { "cost": "2.14", "description": "Librium 25 mg capsule", "unit": "capsule" }, { "cost": "5.78", "description": "Librax capsule", "unit": "capsule" }, { "cost": "6.5", "description": "Librax 2.5-5 mg capsule", "unit": "capsule" }, { "cost": "0.07", "description": "Apo-Chlordiazepoxide 5 mg Capsule", "unit": "capsule" }, { "cost": "0.11", "description": "Apo-Chlordiazepoxide 10 mg Capsule", "unit": "capsule" }, { "cost": "0.14", "description": "Chlordiazepoxide 10 mg capsule", "unit": "capsule" }, { "cost": "0.17", "description": "Apo-Chlordiazepoxide 25 mg Capsule", "unit": "capsule" }, { "cost": "0.2", "description": "Chlordiazepoxide 5 mg capsule", "unit": "capsule" }, { "cost": "0.31", "description": "ChlordiazePOXIDE HCl 10 mg capsule", "unit": "capsule" }, { "cost": "0.31", "description": "ChlordiazePOXIDE HCl 5 mg capsule", "unit": "capsule" }, { "cost": "0.32", "description": "ChlordiazePOXIDE HCl 25 mg capsule", "unit": "capsule" }, { "cost": "0.72", "description": "Chlordiazepoxide 25 mg capsule", "unit": "capsule" }, { "cost": "0.84", "description": "Librium 5 mg capsule", "unit": "capsule" } ]	[]	7-chloro-2-methylamino-5-phenyl-3H-1,4-benzodiazepin-4-oxide \| CDP \| Chloradiazepoxide \| Chlordiazepoxide \| Chlordiazepoxidum \| Clopoxide \| Clordiazepóxido \| Methaminodiazepoxide \| BZRP \| MBR \| Mitochondrial benzodiazepine receptor \| PBR \| Peripheral-type benzodiazepine receptor \| PKBS \| GABA(A) receptor subunit alpha-1 \| GABAAR subunit alpha-1 \| GABA(A) receptor subunit alpha-2 \| GABAAR subunit alpha-2 \| GABA(A) receptor subunit alpha-3 \| GABAAR subunit alpha-3 \| GABA(A) receptor subunit alpha-4 \| GABAAR subunit alpha-4 \| GABA(A) receptor subunit alpha-5 \| GABAAR subunit alpha-5 \| GABA(A) receptor subunit alpha-6 \| GABAAR subunit alpha-6 \| GABA(A) receptor subunit beta-1 \| GABAAR subunit beta-1 \| GABA(A) receptor subunit beta-2 \| GABAAR subunit beta-2 \| GABA(A) receptor subunit beta-3 \| GABAAR subunit beta-3 \| GABA(A) receptor subunit delta \| GABAAR subunit delta \| GABA(A) receptor subunit epsilon \| GABAAR subunit epsilon \| GABA(A) receptor subunit gamma-1 \| GABAAR subunit gamma-1 \| GABA(A) receptor subunit gamma-2 \| GABAAR subunit gamma-2 \| GABA(A) receptor subunit gamma-3 \| GABAAR subunit gamma-3 \| GABA(A) receptor subunit pi \| GABAAR subunit pi \| GABA(A) receptor subunit theta \| GABAAR subunit theta \| GABA(A) receptor subunit alpha-1 \| GABAAR subunit alpha-1 \| GABA(A) receptor subunit alpha-2 \| GABAAR subunit alpha-2 \| GABA(A) receptor subunit alpha-3 \| GABAAR subunit alpha-3 \| GABA(A) receptor subunit alpha-5 \| GABAAR subunit alpha-5 \| GABA(A) receptor subunit gamma-1 \| GABAAR subunit gamma-1 \| GABA(A) receptor subunit gamma-2 \| GABAAR subunit gamma-2 \| GABA(A) receptor subunit gamma-3 \| GABAAR subunit gamma-3 \| 1,4-cineole 2-exo-monooxygenase \| 1,8-cineole 2-exo-monooxygenase \| 1.14.14.1 \| Albendazole monooxygenase (sulfoxide-forming) \| Albendazole sulfoxidase \| Cholesterol 25-hydroxylase \| CYP3A3 \| CYPIIIA3 \| CYPIIIA4 \| Cytochrome P450 3A3 \| Cytochrome P450 HLp \| Cytochrome P450 NF-25 \| Cytochrome P450-PCN1 \| Nifedipine oxidase \| Quinine 3-monooxygenase	[ "Chlorax", "Chlordiazepoxide", "Chlordiazepoxide", "Chlordiazepoxide", "Chlordiazepoxide", "Chlordiazepoxide", "Chlordiazepoxide and Amitriptyline HCl", "Chlordiazepoxide and Amitriptyline HCl", "Chlordiazepoxide and Amitriptyline Hydrochloride", "Chlordiazepoxide and Amitriptyline Hydrochloride", "Chlordiazepoxide and Amitriptyline Hydrochloride", "Chlordiazepoxide and Amitriptyline Hydrochloride", "Chlordiazepoxide and Amitriptyline Hydrochloride", "Chlordiazepoxide and Amitriptyline Hydrochloride", "Chlordiazepoxide Cap 10mg", "Chlordiazepoxide Cap 5mg", "Chlordiazepoxide Clidinium", "Chlordiazepoxide HCl", "Chlordiazepoxide HCl", "Chlordiazepoxide HCl", "Chlordiazepoxide HCl and Clidinium Bromide", "Chlordiazepoxide Hydrochloride", "Chlordiazepoxide Hydrochloride", "Chlordiazepoxide Hydrochloride", "Chlordiazepoxide Hydrochloride", "Chlordiazepoxide Hydrochloride", "Chlordiazepoxide Hydrochloride", "Chlordiazepoxide Hydrochloride", "Chlordiazepoxide Hydrochloride", "Chlordiazepoxide Hydrochloride", "Chlordiazepoxide Hydrochloride", "Chlordiazepoxide Hydrochloride", "Chlordiazepoxide Hydrochloride", "Chlordiazepoxide Hydrochloride", "Chlordiazepoxide Hydrochloride", "Chlordiazepoxide Hydrochloride", "Chlordiazepoxide Hydrochloride", "Chlordiazepoxide Hydrochloride", "Chlordiazepoxide Hydrochloride", "Chlordiazepoxide Hydrochloride", "Chlordiazepoxide Hydrochloride", "Chlordiazepoxide Hydrochloride", "Chlordiazepoxide Hydrochloride", "Chlordiazepoxide Hydrochloride", "Chlordiazepoxide Hydrochloride", "Chlordiazepoxide Hydrochloride", "Chlordiazepoxide Hydrochloride", "Chlordiazepoxide Hydrochloride", "Chlordiazepoxide Hydrochloride", "Chlordiazepoxide Hydrochloride", "Chlordiazepoxide Hydrochloride", "Chlordiazepoxide Hydrochloride", "Chlordiazepoxide Hydrochloride", "Chlordiazepoxide Hydrochloride", "Chlordiazepoxide Hydrochloride", "Chlordiazepoxide Hydrochloride", "Chlordiazepoxide Hydrochloride", "Chlordiazepoxide Hydrochloride", "Chlordiazepoxide Hydrochloride", "Chlordiazepoxide Hydrochloride", "Chlordiazepoxide Hydrochloride", "Chlordiazepoxide Hydrochloride", "Chlordiazepoxide Hydrochloride", "Chlordiazepoxide Hydrochloride", "Chlordiazepoxide Hydrochloride", "Chlordiazepoxide Hydrochloride", "Chlordiazepoxide Hydrochloride", "Chlordiazepoxide Hydrochloride", "Chlordiazepoxide Hydrochloride", "Chlordiazepoxide Hydrochloride", "Chlordiazepoxide Hydrochloride", "Chlordiazepoxide Hydrochloride", "Chlordiazepoxide Hydrochloride", "Chlordiazepoxide Hydrochloride", "Chlordiazepoxide Hydrochloride", "Chlordiazepoxide Hydrochloride", "Chlordiazepoxide Hydrochloride", "Chlordiazepoxide Hydrochloride", "Chlordiazepoxide Hydrochloride", "Chlordiazepoxide Hydrochloride", "Chlordiazepoxide Hydrochloride", "Chlordiazepoxide Hydrochloride", "Chlordiazepoxide Hydrochloride", "Chlordiazepoxide Hydrochloride", "Chlordiazepoxide Hydrochloride", "Chlordiazepoxide Hydrochloride", "Chlordiazepoxide Hydrochloride", "Chlordiazepoxide Hydrochloride", "Chlordiazepoxide Hydrochloride", "Chlordiazepoxide Hydrochloride", "Chlordiazepoxide Hydrochloride", "Chlordiazepoxide Hydrochloride", "Chlordiazepoxide Hydrochloride", "Chlordiazepoxide Hydrochloride", "Chlordiazepoxide Hydrochloride", "Chlordiazepoxide Hydrochloride", "Chlordiazepoxide Hydrochloride and Clidinium Bromide", "Chlordiazepoxide Hydrochloride and Clidinium Bromide", "Chlordiazepoxide Hydrochloride and Clidinium Bromide", "CHLORDIAZEPOXIDE HYDROCHLORIDE and CLIDINIUM BROMIDE", "Chlordiazepoxide Hydrochloride and Clidinium Bromide", "Chlordiazepoxide Hydrochloride and Clidinium Bromide", "Chlordiazepoxide Hydrochloride And Clidinium Bromide", "Chlordiazepoxide Hydrochloride and Clidinium Bromide", "Chlordiazepoxide Hydrochloride and Clidinium Bromide", "CHLORDIAZEPOXIDE HYDROCHLORIDE and CLIDINIUM BROMIDE", "Chlordiazepoxide Hydrochloride and Clidinium Bromide", "Chlordiazepoxide Hydrochloride and Clidinium Bromide", "Chlordiazepoxide Hydrochloride and Clidinium Bromide", "Chlordiazepoxide Hydrochloride and Clidinium Bromide", "Chlordiazepoxide Hydrochloride and Clidinium Bromide", "Chlordiazepoxide Hydrochloride and Clidinium Bromide", "Chlordiazepoxide Hydrochloride and Clidinium Bromide", "Chlordiazepoxide Hydrochloride and Clidinium Bromide", "Chlordiazepoxide Hydrochloride and Clidinium Bromide", "Chlordiazepoxide Hydrochloride and Clidinium Bromide", "Chlordiazepoxide Hydrochloride And Clidinium Bromide", "Chlordiazepoxide Hydrochloride and Clidinium Bromide", "Chlordiazepoxide Hydrochloride and Clidinium Bromide", "Chlordiazepoxide Hydrochloride and Clidinium Bromide", "Chlordiazepoxide Hydrochloride and Clidinium Bromide", "Chlordiazepoxide Hydrochloride and Clidinium Bromide", "Chlordiazepoxide Hydrochloride and Clidinium Bromide", "Chlordiazepoxide Hydrochloride and Clidinium Bromide", "Chlordiazepoxide Hydrochloride and Clidinium Bromide", "Chlordiazepoxide Hydrochloride and Clidinium Bromide", "Chlordiazepoxide Hydrochloride and Clidinium Bromide", "Chlordiazepoxide Hydrochloride and Clidinium Bromide", "Chlordiazepoxide Hydrochloride and Clidinium Bromide", "Chlordiazepoxide Hydrochloride and Clidinium Bromide", "Chlordiazepoxide Hydrochloride and Clidinium Bromide", "Chlordiazepoxide hydrochloride and clidinium bromide", "Chlordiazepoxide hydrochloride and clidinium bromide", "Chlordiazepoxide Hydrochloride and Clidinium Bromide", "Chlordiazepoxide Hydrochloride and Clidinium Bromide", "Chlordiazepoxide Hydrochloride/Clidinium Bromide", "Chlordiazepoxide Hydrochloride/Clidinium Bromide", "Chlordiazepoxide Hydrochloride/Clidinium Bromide", "Chlordiazepoxide Hydrochloride/Clidinium Bromide", "Chlordiazepoxide Hydrochloride/Clidinium Bromide", "Chlordiazepoxide Hydrochloride/Clidinium Bromide", "Chlordiazepoxyde 25 Cap", "Chlordiazepoxyde Cap 10mg", "Chlordiazepoxyde HCl Cap 25mg", "Corax Cap 10mg", "Corax Cap 25mg", "Corax Cap 5mg", "Corium Cap", "Librax", "Librax", "Librium", "Librium", "Librium", "Limbitrol", "Limbitrol", "Limbitrol DS", "Medilium Cap 10 10mg", "Medilium Cap 5mg", "Not applicable", "Novo-poxide 10mg", "Novo-poxide 25mg", "Novo-poxide 5mg", "Nu-chlorax Capsules USP", "Pro Chlorax" ]	[ "Angirex", "Elenium", "Helogaphen", "Klopoxid", "Libritabs", "Multum", "Napoton", "Radepur", "Risolid", "Silibrin", "Sonimen", "Tropium" ]	[ "Chlordiazepoxide Clidinium", "Chlordiazepoxide and Amitriptyline Hydrochloride", "Chlordiazepoxide and Amitriptyline Hydrochloride", "Chlordiazepoxide Hydrochloride and Clidinium Bromide", "Chlordiazepoxide Hydrochloride and Clidinium Bromide", "Chlordiazepoxide Hydrochloride and Clidinium Bromide", "CHLORDIAZEPOXIDE HYDROCHLORIDE and CLIDINIUM BROMIDE", "Chlordiazepoxide Hydrochloride and Clidinium Bromide", "Chlordiazepoxide Hydrochloride and Clidinium Bromide", "Chlordiazepoxide Hydrochloride And Clidinium Bromide", "Chlordiazepoxide Hydrochloride and Clidinium Bromide", "Limbitrol", "Limbitrol", "Limbitrol DS", "Chlordiazepoxide Hydrochloride and Clidinium Bromide", "CHLORDIAZEPOXIDE HYDROCHLORIDE and CLIDINIUM BROMIDE", "Chlordiazepoxide Hydrochloride and Clidinium Bromide", "Chlordiazepoxide Hydrochloride and Clidinium Bromide", "Chlordiazepoxide Hydrochloride/Clidinium Bromide", "Chlordiazepoxide Hydrochloride and Clidinium Bromide", "Chlordiazepoxide Hydrochloride and Clidinium Bromide", "Chlordiazepoxide Hydrochloride and Clidinium Bromide", "Chlordiazepoxide and Amitriptyline Hydrochloride", "Chlordiazepoxide and Amitriptyline Hydrochloride", "Chlordiazepoxide Hydrochloride and Clidinium Bromide", "Chlordiazepoxide Hydrochloride/Clidinium Bromide", "Chlordiazepoxide Hydrochloride and Clidinium Bromide", "Chlordiazepoxide Hydrochloride/Clidinium Bromide", "Chlordiazepoxide Hydrochloride and Clidinium Bromide", "Chlordiazepoxide Hydrochloride and Clidinium Bromide", "Chlordiazepoxide Hydrochloride and Clidinium Bromide", "Librax", "Chlordiazepoxide Hydrochloride And Clidinium Bromide", "Chlordiazepoxide Hydrochloride/Clidinium Bromide", "Chlordiazepoxide and Amitriptyline HCl", "Chlordiazepoxide and Amitriptyline HCl", "Chlordiazepoxide Hydrochloride and Clidinium Bromide", "Not applicable", "Chlordiazepoxide Hydrochloride/Clidinium Bromide", "Chlordiazepoxide Hydrochloride and Clidinium Bromide", "Chlordiazepoxide Hydrochloride and Clidinium Bromide", "Chlordiazepoxide Hydrochloride and Clidinium Bromide", "Chlordiazepoxide Hydrochloride and Clidinium Bromide", "Chlordiazepoxide Hydrochloride/Clidinium Bromide", "Chlordiazepoxide Hydrochloride and Clidinium Bromide", "Chlordiazepoxide Hydrochloride and Clidinium Bromide", "Chlordiazepoxide Hydrochloride and Clidinium Bromide", "Chlorax", "Librax", "Corium Cap", "Pro Chlorax", "Nu-chlorax Capsules USP", "Chlordiazepoxide Hydrochloride and Clidinium Bromide", "Chlordiazepoxide Hydrochloride and Clidinium Bromide", "Chlordiazepoxide and Amitriptyline Hydrochloride", "Chlordiazepoxide and Amitriptyline Hydrochloride", "Chlordiazepoxide Hydrochloride and Clidinium Bromide", "Chlordiazepoxide HCl and Clidinium Bromide", "Chlordiazepoxide Hydrochloride and Clidinium Bromide", "Chlordiazepoxide Hydrochloride and Clidinium Bromide", "Chlordiazepoxide Hydrochloride and Clidinium Bromide", "Chlordiazepoxide hydrochloride and clidinium bromide", "Chlordiazepoxide hydrochloride and clidinium bromide", "Chlordiazepoxide Hydrochloride and Clidinium Bromide", "Chlordiazepoxide Hydrochloride and Clidinium Bromide" ]	[ "P30536", "P14867", "P47869", "P34903", "P48169", "P31644", "Q16445", "P18505", "P47870", "P28472", "O14764", "P78334", "Q8N1C3", "P18507", "Q99928", "O00591", "Q9UN88", "P14867", "P47869", "P34903", "P31644", "Q8N1C3", "P18507", "Q99928" ]	[ "P08684" ]	[]	[]
DB00476	Duloxetine	Duloxetine is a dual serotonin and norepinephrine reuptake inhibitor.[label] It was originally discovered in 1993 and developed by Eli Lilly and Company as LY248686.[A178741] Duloxetine first received approval from the FDA in August, 2004 as Cymbalta for the treatment of Major Depressive Disorder.[L6454] It has since received approval for a variety of indications including the treatment of neuropathic pain, Generalized Anxiety disorder, osteoarthritis, and stress incontinence. Duloxetine continues to be investigated for the treatment of pain in cancer, surgery, and more.	solid	Indicated for: 1) Management of Major Depressive Disorder.[label] 2) Management of Generalized Anxiety Disorder.[label] 3) Management of diabetic peripheral neuropathy.[label] 4) Management of fibromyalgia.[label] 5) Management of chronic musculoskeletal pain.[label] 6) Management of osteoarthritis of the knee in adults.[L6364] 7) Management of chronic lower back pain in adults.[L6364] 8) Management of stress urinary incontinence in adult women.[L6367] Off-label uses include: 1) Management of chemotherapy-induced peripheral neuropathy.[A178603] 2) Management of stress urinary incontinence in adult men after prostatectomy until recovery is complete.[L6370]	Duloxetine, through increasing serotonin and norepinephrine concentrations in Onuf's nucleus, enhances glutamatergic activation of the pudendal motor nerve which innervates the external urethral sphinter.[A178663,A178666] This enhanced signaling allows for stronger contraction. Increased contraction of this sphincter increases the pressure needed to produce an incontinence episode in stress urinary incontinence. Duloxetine has been shown to improve Patient Global Impression of Improvement and Incontinence Quality of Life scores.[A178669] It has also been shown to reduce the median incontinence episode frequency at doses of 40 and 80 mg. Action at the dorsal horn of the spinal cord allows duloxetine to strengthen the the serotonergic and adrenergic pathways involved in descending inhibition of pain.[A178666,A178705] This results in an increased threshold of activation necessary to transmit painful stimuli to the brain and effective relief of pain, particularly in neuropathic pain. Pain relief has been noted in a variety of painful conditions including diabetic peripheral neuropathy, fibromyalgia, and osteoarthritis using a range of pain assessment surveys.[A178711] While duloxetine has been shown to be effective in both animal models of mood disorders and in clinical trials for the treatment of these disorders in humans, the broad scope of its pharmacodynamic effects on mood regulation in the brain has yet to be explained.[A178714] Increased blood pressure is a common side effect with duloxetine due to vasoconstriction mediated by the intended increase in norepinephrine signaling.[label,T116]	Duloxetine is a potent inhibitor of neuronal serotonin and norepinephrine reuptake and a less potent inhibitor of dopamine reuptake.[A178714] Duloxetine has no significant affinity for dopaminergic, adrenergic, cholinergic, histaminergic, opioid, glutamate, and GABA receptors. Action on the external urinary sphincter is mediated via duloxetine's CNS effects. Increased serotonin and norepinephrine concentrations in Onuf's nucleus leads to increased activation of 5-HT<sub>2</sub>, 5-HT<sub>3</sub>, and α<sub>1</sub> adrenergic receptors.[A178663,A178666] 5-HT<sub>2</sub> and α<sub>1</sub> are both G<sub>q</sub> coupled and their activation increases the activity of the inositol trisphosphate/phospholipase C (IP<sub>3</sub>/PLC) pathway.[T116] This pathway leads to release of intracellular calcium stores, increasing intracellular calcium concentrations, and facilitating neuronal excitability. 5-HT<sub>3</sub> functions as a ligand-gated sodium channel which allows sodium to flow into the neuron when activated. Increased flow of sodium into the neuron contributes to depolarization and activation of voltage gated channels involved in action potential generation. The combined action of these three receptors contributes to increased excitability of the pudendal motor nerve in response to glutamate. Also related to duloxetine's action at the spinal cord is its modulation of pain. Increasing the concentration of serotonin and norepinephrine in the dorsal horn of the spinal cord increases descending inhibition of pain through activation of 5-HT<sub>1A</sub>, 5-HT<sub>1B</sub>, 5-HT<sub>1D</sub>, 5-HT<sub>2</sub>, 5-HT<sub>3</sub>, α<sub>1</sub>-adrenergic, and α<sub>2</sub>-adrenergic receptors.[A178705] 5-HT<sub>2</sub>, 5-HT<sub>3</sub>, and α<sub>1</sub>-adrenergic mediate neuronal activation as described above. The activated neuron in this case is the GABAergic inhibitory interneuron which synapses onto the nociceptive projection neuron to inhibit the transmission of painful stimuli to the brain. The 5-HT<sub>1</sub> and α<sub>2</sub> receptors are G<sub>i</sub>/G<sub>o</sub> coupled and their activation leads to increased potassium current through inward rectifier channels and decreased adenylyl cyclase/protein kinase A signaling which contributes to neuronal inhibition.[A178705,T116] These inhibitory receptors are present on the projection neuron itself as well as the dorsal root ganglion which precedes it and serves to directly suppress the transmission of painful stimuli. The mechanisms involved in duloxetine's benefits in depression and anxiety have not been fully elucidated. Dysfunctional serotonin and norepinephrine signaling are thought to be involved and increases in the availability of these neurotransmitters at the synaptic cleft thought to mediate a therapeutic effect.[A178666] It is postulated that the involvement of serotonin and norepinephrine in area responsible for emotional modulation such as the limbic system contributes to the effects in mood disorders specifically but this has yet to be confirmed. Duloxetine's hypertensive effect is related to its intended pharmacological effect. Increased availability of norepinephrine leads to activation of adrenergic receptors on the vascular endothelium. Since the action of α<sub>1</sub> receptors predominates, vasoconstriction results as the G<sub>q</sub> coupled receptor mediates calcium release from the sarcoplasmic reticulum to facilitate smooth muscle contraction.[T116]	Duloxetine is incompletely absorbed with a mean bioavailability of 50% although there is wide variability in the range of 30-80%.[A14807] The population absorption constant (ka) is 0.168 h<sup>-1</sup>.The molecule is susceptible to hydrolysis in acidic environments necessitating the use of an enteric coating to protect it during transit through the stomach. This creates a 2 hour lag time from administration to the start of absorption. The Tmax is 6 hours including the lag time.[label] Administering duloxetine with food 3 hour delay in Tmax along with an 10% decrease in AUC. Similarly, administering the dose at bedtime produces a 4 hour delay and 18% decrease in AUC with a 29% reduction in Cmax.[A14807] These are attributed to delayed gastric emptying in both cases but are not expected to impact therapy to a clinically significant degree.	Duloxetine is extensively metabolized primarily by CYP1A2 and CYP2D6 with the former being the greater contributor.[label,A14807] It is hydroxylated at the 4, 5, or 6 positions on the naphthalene ring with the 4-hydroxy metabolite proceeding directly to a glucuronide conjugate while the 5 and 6-hydroxy metabolites proceed through a catechol and a 5-hydroxy, 6-methoxy intermediate before undergoing glucuronide or sulfate conjugation. CYP2C9 is known to be a minor contributor to the 5-hydroxy metabolite. Another uncharacterized metabolite is known to be excreted in the feces but comprises <5% of the total excreted drug. Many other metabolites exist but have not been identified due their low contribution to the overall profile of duloxetine and lack of clinical significance.	Overdose Fatalities have been reported with doses of 1000mg involving both mixed drugs as well as duloxetine alone.[label] Signs and symptoms of overdose include: somnolence, coma, serotonin syndrome, seizure, syncope, hypo- or hypertension, tachycardia, and vomiting. No antidote exists and the drug is unlikely to be cleared by hemodialysis. Supportive care is recommended along with activated charcoal and gastric lavage to reduce absorption. If serotonin syndrome occurs specific treatment such as temperature control or cyproheptadine may be initiated. Carcinogenicity & Mutagenicity Increased incidence of hepatocellular carcinomas and adenomas were reported in female mice fed 140 mg/kg/day duloxetine for 2 years, equivalent to 6 times the maximum recommended human dose (MRHD).[label] No effect was reported with doses of 50mg/kg/day (2 time MRHD) in females or 100 mg/kg/day in males (4 times MRHD). Similar investigation in rats produced no carcinogenicity at doses of 27 mg/kg/day (2 times MRHD)in females and 36 mg/kg/day in males (4 times MRHD). No mutagenicity, clastogenicity, induction of sister chromatid exchange, or genotoxicity has been observed in toxicology investigations. Reproductive Toxicity Neither male or female rats displayed adverse reproductive effects at doses up to 45 mg/kg/day (4 times MRHD).[label] Lactation An estimated 25% of plasma duloxetine appears in breast milk with the estimated daily infant dose being 0.14% of the maternal dose.[label] Breast milk concentrations have been observed to peak 3 hours after administration.	Mean of 12 h with a range of 8-17.[label,A14807]	Over 90% bound to plasma proteins, primarily albumin and α1 acid-glycoprotein.[label,A14807]	About 70% of duloxetine is excreted in the urine mainly as conjugated metabolites.[label] Another 20% is present in the feces as the parent drug, 4-hydroxy metabolite, and an uncharacterized metabolite.[label,A14807] Biliary secretion is thought to play a role due to timeline of fecal excretion exceeding the time expected of normal GI transit.[A14807]	Apparent Vd of 1620-1800 L.[label,A14807] Duloxetine crosses the blood-brain barrier and collects in the cerebral cortex at a higher concentration than the plasma.[A14807]	There is a large degree of interindividual variation reported in the clearance of duloxetine with values ranging from 57-114 L/h.[A14807] Steady state concentrations have still been shown to be dose proportional with a doubling of dose from 30 to 60 mg and from 60 to 120 mg producing 2.3 and 2.6 times the Css respectively.	Organic compounds	Benzenoids	Naphthalenes	null	[ "approved" ]	[ "N06AX", "N06A", "N06", "N" ]	[ "Humans and other mammals" ]	[ { "cost": "4.62", "description": "Cymbalta 20 mg capsule", "unit": "capsule" }, { "cost": "4.64", "description": "Cymbalta 20 mg Enteric Coated Capsule", "unit": "capsule" }, { "cost": "5.18", "description": "Cymbalta 30 mg capsule", "unit": "capsule" }, { "cost": "5.18", "description": "Cymbalta 60 mg capsule", "unit": "capsule" }, { "cost": "5.38", "description": "Cymbalta 30 mg Enteric Coated Capsule", "unit": "capsule" }, { "cost": "5.38", "description": "Cymbalta 60 mg Enteric Coated Capsule", "unit": "capsule" } ]	[ { "approved": "1991-06-11", "country": "United States", "expires": "2013-06-11", "number": "5023269" }, { "approved": "2008-11-18", "country": "Canada", "expires": "2019-09-10", "number": "2344057" }, { "approved": "2005-05-10", "country": "Canada", "expires": "2015-07-13", "number": "2153856" }, { "approved": "2003-07-22", "country": "United States", "expires": "2020-03-10", "number": "6596756" }, { "approved": "2017-12-12", "country": "United States", "expires": "2037-04-13", "number": "9839626" }, { "approved": "2019-09-17", "country": "United States", "expires": "2037-04-13", "number": "10413525" }, { "approved": "2021-03-30", "country": "United States", "expires": "2037-04-13", "number": "10959982" }, { "approved": "2021-12-21", "country": "United States", "expires": "2037-04-13", "number": "11202772" } ]	(3S)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propan-1-amine \| (S)-duloxetine \| Duloxetina \| Duloxetine \| 5HT transporter \| 5HTT \| HTT \| SERT \| Solute carrier family 6 member 4 \| NAT1 \| NET \| NET1 \| Norepinephrine transporter \| SLC6A5 \| Solute carrier family 6 member 2 \| DA transporter \| DAT \| DAT1 \| Solute carrier family 6 member 3 \| 1.14.14.- \| Cholesterol 25-hydroxylase \| CYP2DL1 \| CYPIID6 \| Cytochrome P450-DB1 \| Debrisoquine 4-hydroxylase \| (R)-limonene 6-monooxygenase \| (S)-limonene 6-monooxygenase \| (S)-limonene 7-monooxygenase \| 1.14.14.1 \| Cholesterol 25-hydroxylase \| CYP2C10 \| CYPIIC9 \| Cytochrome P-450MP \| Cytochrome P450 MP-4 \| Cytochrome P450 MP-8 \| Cytochrome P450 PB-1 \| S-mephenytoin 4-hydroxylase \| 1,4-cineole 2-exo-monooxygenase \| 1,8-cineole 2-exo-monooxygenase \| 1.14.14.1 \| Albendazole monooxygenase (sulfoxide-forming) \| Albendazole sulfoxidase \| Cholesterol 25-hydroxylase \| CYP3A3 \| CYPIIIA3 \| CYPIIIA4 \| Cytochrome P450 3A3 \| Cytochrome P450 HLp \| Cytochrome P450 NF-25 \| Cytochrome P450-PCN1 \| Nifedipine oxidase \| Quinine 3-monooxygenase \| 1.14.14.1 \| Cholesterol 25-hydroxylase \| CYPIA2 \| Cytochrome P(3)450 \| Cytochrome P450 4 \| Cytochrome P450-P3 \| Hydroperoxy icosatetraenoate dehydratase \| 1,4-cineole 2-exo-monooxygenase \| 1.14.13.- \| CYPIIB6 \| Cytochrome P450 IIB1 \| (R)-limonene 6-monooxygenase \| (S)-limonene 6-monooxygenase \| (S)-limonene 7-monooxygenase \| 1.14.14.1 \| CYPIIC17 \| CYPIIC19 \| Cytochrome P450-11A \| Cytochrome P450-254C \| Fenbendazole monooxygenase (4'-hydroxylating) \| Mephenytoin 4-hydroxylase \| AGP 1 \| AGP1 \| OMD 1 \| Orosomucoid-1 \| AGP 2 \| AGP2 \| OMD 2 \| Orosomucoid-2 \| ATP-binding cassette sub-family B member 1 \| MDR1 \| Multidrug resistance protein 1 \| P-glycoprotein 1 \| PGY1 \| Phospholipid transporter ABCB1	[ "Accel-duloxetine", "Accel-duloxetine", "Ag-duloxetine", "Ag-duloxetine", "Apo-duloxetine", "Apo-duloxetine", "Ariclaim", "Ariclaim", "Ariclaim", "Ariclaim", "Ariclaim", "Auro-duloxetine", "Auro-duloxetine", "Bio-duloxetine", "Bio-duloxetine", "Cymbalta", "Cymbalta", "Cymbalta", "Cymbalta", "Cymbalta", "Cymbalta", "Cymbalta", "Cymbalta", "Cymbalta", "Cymbalta", "Cymbalta", "Cymbalta", "Cymbalta", "Cymbalta", "Cymbalta", "Cymbalta", "Cymbalta", "Cymbalta", "Cymbalta", "Cymbalta", "Cymbalta", "Cymbalta", "Cymbalta", "Cymbalta", "Cymbalta", "Cymbalta", "Cymbalta", "Cymbalta", "Cymbalta", "Cymbalta", "Cymbalta", "Cymbalta", "Cymbalta", "Cymbalta", "Cymbalta", "Cymbalta", "Cymbalta", "Cymbalta", "Cymbalta", "Cymbalta", "Cymbalta", "Cymbalta", "Cymbalta", "Cymbalta", "Cymbalta", "Cymbalta", "Cymbalta", "Cymbalta", "Cymbalta", "DermacinRx DPN Pak", "Dom-duloxetine", "Dom-duloxetine", "Drizalma Sprinkle", "Drizalma Sprinkle", "Drizalma Sprinkle", "Drizalma Sprinkle", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine", "Duloxetine Delayed-release", "Duloxetine Delayed-release", "Duloxetine Delayed-release", "Duloxetine Delayed-release", "Duloxetine Delayed-release", "Duloxetine Delayed-Release", "Duloxetine Delayed-Release", "Duloxetine Delayed-Release", "Duloxetine Delayed-release", "Duloxetine Delayed-Release", "Duloxetine Delayed-Release", "Duloxetine Delayed-Release", "Duloxetine Delayed-Release", "Duloxetine Delayed-release", "Duloxetine Delayed-release", "Duloxetine Delayed-release", "Duloxetine Delayed-Release", "Duloxetine Delayed-Release", "Duloxetine Delayed-Release", "Duloxetine Delayed-Release", "Duloxetine Delayed-Release", "Duloxetine Delayed-release", "Duloxetine Delayed-release", "Duloxetine Delayed-Release", "Duloxetine Delayed-release", "Duloxetine Delayed-Release", "Duloxetine Delayed-Release", "Duloxetine Delayed-Release", "Duloxetine Delayed-Release", "Duloxetine Delayed-Release", "Duloxetine Delayed-Release", "Duloxetine Delayed-Release", "Duloxetine Delayed-Release", "Duloxetine Delayed-Release", "Duloxetine Delayed-Release", "Duloxetine Delayed-release", "Duloxetine Delayed-Release", "Duloxetine Delayed-Release", "Duloxetine Delayed-Release", "Duloxetine Delayed-Release", "Duloxetine Delayed-Release", "Duloxetine Delayed-Release", "Duloxetine Delayed-Release", "Duloxetine Delayed-Release", "Duloxetine Delayed-Release", "Duloxetine Delayed-Release", "Duloxetine Delayed-Release", "Duloxetine Delayed-Release", "Duloxetine Delayed-Release", "Duloxetine Delayed-Release", "Duloxetine Delayed-Release", "Duloxetine Delayed-Release", "Duloxetine Delayed-Release", "Duloxetine Delayed-Release", "Duloxetine Delayed-Release", "Duloxetine Delayed-Release", "Duloxetine Delayed-Release", "Duloxetine Delayed-Release", "Duloxetine Delayed-Release", "Duloxetine Delayed-Release", "Duloxetine Delayed-Release", "Duloxetine Delayed-release Delayed-release", "Duloxetine DR", "Duloxetine DR", "Duloxetine DR", "Duloxetine DR", "Duloxetine HCL DR", "Duloxetine HCL DR", "Duloxetine HCL DR", "Duloxetine HCL DR", "Duloxetine HCL DR", "Duloxetine hydrochloride", "Duloxetine hydrochloride", "Duloxetine hydrochloride", "Duloxetine Hydrochloride", "Duloxetine Hydrochloride", "Duloxetine hydrochloride", "Duloxetine hydrochloride", "Duloxetine Hydrochloride", "Duloxetine Hydrochloride", "Duloxetine Hydrochloride", "Duloxetine Hydrochloride", "Duloxetine Hydrochloride", "Duloxetine Hydrochloride", "Duloxetine Hydrochloride", "Duloxetine hydrochloride", "Duloxetine hydrochloride", "Duloxetine hydrochloride", "Duloxetine hydrochloride", "Duloxetine Hydrochloride", "Duloxetine Hydrochloride", "Duloxetine Hydrochloride", "Duloxetine Hydrochloride", "Duloxetine Hydrochloride", "Duloxetine Hydrochloride", "Duloxetine Hydrochloride", "Duloxetine Hydrochloride", "Duloxetine Hydrochloride", "Duloxetine hydrochloride", "Duloxetine hydrochloride", "Duloxetine hydrochloride", "Duloxetine Hydrochloride", "Duloxetine Hydrochloride", "Duloxetine Hydrochloride", "Duloxetine Hydrochloride", "Duloxetine Hydrochloride", "Duloxetine Hydrochloride", "Duloxetine Hydrochloride", "Duloxetine Hydrochloride", "Duloxetine Hydrochloride", "Duloxetine Hydrochloride", "Duloxetine Hydrochloride", "Duloxetine Hydrochloride", "Duloxetine Hydrochloride", "Duloxetine Hydrochloride", "Duloxetine Hydrochloride", "Duloxetine hydrochloride", "Duloxetine Hydrochloride", "Duloxetine hydrochloride", "Duloxetine Hydrochloride", "Duloxetine Hydrochloride", "Duloxetine hydrochloride", "Duloxetine hydrochloride", "Duloxetine hydrochloride", "Duloxetine hydrochloride", "Duloxetine hydrochloride", "Duloxetine Hydrochloride", "Duloxetine Hydrochloride", "Duloxetine hydrochloride", "Duloxetine hydrochloride", "Duloxetine Hydrochloride 20 mg", "Duloxetine Hydrochloride 20 mg", "Duloxetine Hydrochloride 20 mg", "Duloxetine Hydrochloride 30 mg", "Duloxetine Hydrochloride 30 mg", "Duloxetine Hydrochloride 60 mg", "Duloxetine Hydrochloride Delayed Release", "Duloxetine Lilly", "Duloxetine Lilly", "Duloxetine Lilly", "Duloxetine Lilly", "Duloxetine Lilly", "Duloxetine Lilly", "Duloxetine Lilly", "Duloxetine Lilly", "Duloxetine Lilly", "Duloxetine Mylan", "Duloxetine Mylan", "Duloxetine Mylan", "Duloxetine Mylan", "Duloxetine Mylan", "Duloxetine Mylan", "Duloxetine Mylan", "Duloxetine Mylan", "Duloxetine Mylan", "Duloxetine Mylan", "Duloxetine Mylan", "Duloxetine Mylan", "Duloxetine Mylan", "Duloxetine Mylan", "Duloxetine Mylan", "Duloxetine Mylan", "Duloxetine Mylan", "Duloxetine Mylan", "Duloxetine Mylan", "Duloxetine Mylan", "Duloxetine Mylan", "Duloxetine Mylan", "Duloxetine Mylan", "Duloxetine Mylan", "Duloxetine Mylan", "Duloxetine Mylan", "Duloxetine Mylan", "Duloxetine Mylan", "Duloxetine Mylan", "Duloxetine Mylan", "Duloxetine Mylan", "Duloxetine Mylan", "Duloxetine Mylan", "Duloxetine Mylan", "Duloxetine Mylan", "Duloxetine Mylan", "Duloxetine Mylan", "Duloxetine Mylan", "Duloxetine Mylan", "Duloxetine Mylan", "Duloxetine Mylan", "Duloxetine Mylan", "Duloxetine Mylan", "Duloxetine Mylan", "Duloxetine Mylan", "Duloxetine Mylan", "Duloxetine Mylan", "Duloxetine Mylan", "Duloxetine Mylan", "Duloxetine Mylan", "Duloxetine Mylan", "Duloxetine Mylan", "Duloxetine Mylan", "Duloxetine Mylan", "Duloxetine Zentiva", "Duloxetine Zentiva", "Duloxetine Zentiva", "Duloxetine Zentiva", "Duloxetine Zentiva", "Duloxetine Zentiva", "Duloxetine Zentiva", "Duloxetine Zentiva", "Duloxetine Zentiva", "Duloxetine Zentiva", "Duloxetine Zentiva", "Duloxetine Zentiva", "Duloxetine Zentiva", "Duloxetine Zentiva", "Duloxetine Zentiva", "Duloxetine Zentiva", "Duloxetine Zentiva", "Duloxetine Zentiva", "Duloxetine Zentiva", "Duloxetine Zentiva", "Duloxicaine", "Ipg-duloxetine", "Ipg-duloxetine", "Irenka", "Jamp Duloxetine", "Jamp Duloxetine", "Jamp Duloxetine Capsules", "Jamp Duloxetine Capsules", "Jamp-duloxetine", "Jamp-duloxetine", "M-duloxetine", "M-duloxetine", "Mar-duloxetine", "Mar-duloxetine", "Mint-duloxetine", "Mint-duloxetine", "Mylan-duloxetine", "Mylan-duloxetine", "Na", "Na", "Na", "Nodetrip", "Nodetrip", "Nodetrip", "Nodetrip", "Nodetrip", "Nodetrip", "Nodetrip", "Nodetrip", "Nra-duloxetine", "Nra-duloxetine", "PMS-duloxetine", "PMS-duloxetine", "Priva-duloxetine", "Priva-duloxetine", "Ran-duloxetine", "Ran-duloxetine", "Riva-duloxetine", "Riva-duloxetine", "Sandoz Duloxetine", "Sandoz Duloxetine", "Str-duloxetine", "Str-duloxetine", "Taro-duloxetine", "Taro-duloxetine", "Teva-duloxetine", "Teva-duloxetine", "Teva-duloxetine Dr", "Teva-duloxetine Dr", "Torrent-duloxetine", "Torrent-duloxetine", "Yentreve", "Yentreve", "Yentreve", "Yentreve", "Yentreve", "Yentreve", "Yentreve", "Yentreve" ]	[ "Dulane", "Duzela" ]	[ "DermacinRx DPN Pak", "Duloxicaine" ]	[ "P31645", "P23975", "Q01959" ]	[ "P10635", "P11712", "P08684", "P05177", "P20813", "P33261" ]	[ "P02768", "P02763", "P19652" ]	[ "P08183" ]
DB00477	Chlorpromazine	The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class, chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking dopamine receptors. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.	liquid	For the treatment of schizophrenia; to control nausea and vomiting; for relief of restlessness and apprehension before surgery; for acute intermittent porphyria; as an adjunct in the treatment of tetanus; to control the manifestations of the manic type of manic-depressive illness; for relief of intractable hiccups; for the treatment of severe behavioral problems in children (1 to 12 years of age) marked by combativeness and/or explosive hyperexcitable behavior (out of proportion to immediate provocations), and in the short-term treatment of hyperactive children who show excessive motor activity with accompanying conduct disorders consisting of some or all of the following symptoms: impulsivity, difficulty sustaining attention, aggressivity, mood lability, and poor frustration tolerance.	Chlorpromazine is a psychotropic agent indicated for the treatment of schizophrenia. It also exerts sedative and antiemetic activity. Chlorpromazine has actions at all levels of the central nervous system-primarily at subcortical levels-as well as on multiple organ systems. Chlorpromazine has strong antiadrenergic and weaker peripheral anticholinergic activity; ganglionic blocking action is relatively slight. It also possesses slight antihistaminic and antiserotonin activity.	Chlorpromazine acts as an antagonist (blocking agent) on different postsysnaptic receptors -on dopaminergic-receptors (subtypes D1, D2, D3 and D4 - different antipsychotic properties on productive and unproductive symptoms), on serotonergic-receptors (5-HT1 and 5-HT2, with anxiolytic, antidepressive and antiaggressive properties as well as an attenuation of extrapypramidal side-effects, but also leading to weight gain, fall in blood pressure, sedation and ejaculation difficulties), on histaminergic-receptors (H1-receptors, sedation, antiemesis, vertigo, fall in blood pressure and weight gain), alpha1/alpha2-receptors (antisympathomimetic properties, lowering of blood pressure, reflex tachycardia, vertigo, sedation, hypersalivation and incontinence as well as sexual dysfunction, but may also attenuate pseudoparkinsonism - controversial) and finally on muscarinic (cholinergic) M1/M2-receptors (causing anticholinergic symptoms like dry mouth, blurred vision, obstipation, difficulty/inability to urinate, sinus tachycardia, ECG-changes and loss of memory, but the anticholinergic action may attenuate extrapyramidal side-effects). Additionally, Chlorpromazine is a weak presynaptic inhibitor of Dopamine reuptake, which may lead to (mild) antidepressive and antiparkinsonian effects. This action could also account for psychomotor agitation and amplification of psychosis (very rarely noted in clinical use).	Readily absorbed from the GI tract. Bioavailability varies due to first-pass metabolism by the liver.	Extensively metabolized in the liver and kidneys. It is extensively metabolized by cytochrome P450 isozymes CYP2D6 (major pathway), CYP1A2 and CYP3A4. Approximately 10 to 12 major metabolite have been identified. Hydroxylation at positions 3 and 7 of the phenothiazine nucleus and the N-dimethylaminopropyl side chain undergoes demethylation and is also metabolized to an N-oxide. In urine, 20% of chlopromazine and its metabolites are excreted unconjugated in the urine as unchanged drug, demonomethylchlorpromazine, dedimethylchlorpromazine, their sulfoxide metabolites, and chlorpromazine-N-oxide. The remaining 80% consists of conjugated metabolites, principally O-glucuronides and small amounts of ethereal sulfates of the mono- and dihydroxy-derivatives of chlorpromazine and their sulfoxide metabolites. The major metabolites are the monoglucuronide of N-dedimethylchlorpromazine and 7-hydroxychlorpromazine. Approximately 37% of the administered dose of chlorpromazine is excreted in urine.	Agitation, coma, convulsions, difficulty breathing, difficulty swallowing, dry mouth, extreme sleepiness, fever, intestinal blockage, irregular heart rate, low blood pressure, restlessness	~ 30 hours	> 90% to plasma proteins, primarily albumin	Kidneys, ~ 37% excreted in urine	* 20 L/kg	null	Organic compounds	Organoheterocyclic compounds	Benzothiazines	Phenothiazines	[ "approved", "investigational", "vet_approved" ]	[ "N05AA", "N05A", "N05", "N" ]	[ "Humans and other mammals" ]	[ { "cost": "1.05", "description": "Chlorpromazine 200 mg tablet", "unit": "tablet" }, { "cost": "1.19", "description": "ChlorproMAZINE HCl 200 mg tablet", "unit": "tablet" }, { "cost": "8.04", "description": "Chlorpromazine 25 mg/ml amp", "unit": "ml" }, { "cost": "0.17", "description": "Chlorpromazine 25 mg tablet", "unit": "tablet" }, { "cost": "0.3", "description": "Chlorpromazine 50 mg tablet", "unit": "tablet" }, { "cost": "0.32", "description": "Chlorpromazine 10 mg tablet", "unit": "tablet" }, { "cost": "0.37", "description": "ChlorproMAZINE HCl 10 mg tablet", "unit": "tablet" }, { "cost": "0.39", "description": "Chlorpromazine 100 mg tablet", "unit": "tablet" }, { "cost": "0.55", "description": "ChlorproMAZINE HCl 25 mg tablet", "unit": "tablet" }, { "cost": "0.73", "description": "ChlorproMAZINE HCl 50 mg tablet", "unit": "tablet" }, { "cost": "0.84", "description": "ChlorproMAZINE HCl 100 mg tablet", "unit": "tablet" } ]	[]	3-(2-chloro-10H-phenothiazin-10-yl)-N,N-dimethyl-1-propanamine \| 3-(2-chlorophenothiazin-10-yl)-N,N-dimethyl-propan-1-amine \| Chlorpromazine \| Chlorpromazinum \| Clorpromazina \| CPZ \| N-(3-dimethylaminopropyl)-3-chlorophenothiazine \| Dopamine D2 receptor \| Dopamine D1 receptor \| 5-HT-1A \| 5-HT1A \| ADRB2RL1 \| ADRBRL1 \| G-21 \| Serotonin receptor 1A \| 5-HT-2 \| 5-HT-2A \| HTR2 \| Serotonin receptor 2A \| ADRA1C \| Alpha-1A adrenoceptor \| Alpha-1A adrenoreceptor \| Alpha-1C adrenergic receptor \| Alpha-adrenergic receptor 1c \| Alpha-1B adrenoceptor \| Alpha-1B adrenoreceptor \| H1-R \| H1R \| HH1R \| Eag homolog \| Eag-related protein 1 \| ERG \| ERG-1 \| ERG1 \| Ether-a-go-go-related gene potassium channel 1 \| Ether-a-go-go-related protein 1 \| H-ERG \| HERG \| hERG-1 \| hERG1 \| Potassium voltage-gated channel subfamily H member 2 \| Voltage-gated potassium channel subunit Kv11.1 \| Dopamine D1 receptor \| D(5) dopamine receptor \| D1beta dopamine receptor \| Dopamine D5 receptor \| DRD1B \| DRD1L2 \| Dopamine D3 receptor \| D(2C) dopamine receptor \| Dopamine D4 receptor \| D(5) dopamine receptor \| D1beta dopamine receptor \| Dopamine D5 receptor \| DRD1B \| DRD1L2 \| 5-HT-1C \| 5-HT-2C \| 5-HT1C \| 5-HT2C \| 5-HTR2C \| 5-hydroxytryptamine receptor 1C \| HTR1C \| Serotonin receptor 2C \| 5-HT-2 \| 5-HT-2A \| HTR2 \| Serotonin receptor 2A \| 5-HT-2B \| 5-HT2B \| Serotonin receptor 2B \| 5-HT-1C \| 5-HT-2C \| 5-HT1C \| 5-HT2C \| 5-HTR2C \| 5-hydroxytryptamine receptor 1C \| HTR1C \| Serotonin receptor 2C \| ADRA1C \| Alpha-1A adrenoceptor \| Alpha-1A adrenoreceptor \| Alpha-1C adrenergic receptor \| Alpha-adrenergic receptor 1c \| Alpha-1B adrenoceptor \| Alpha-1B adrenoreceptor \| ADRA1A \| Alpha-1A adrenergic receptor \| Alpha-1D adrenoceptor \| Alpha-1D adrenoreceptor \| Alpha-adrenergic receptor 1a \| ADRA2R \| ADRAR \| Alpha-2 adrenergic receptor subtype C10 \| Alpha-2A adrenoceptor \| Alpha-2A adrenoreceptor \| Alpha-2AAR \| ADRA2L1 \| ADRA2RL1 \| Alpha-2 adrenergic receptor subtype C2 \| Alpha-2B adrenoceptor \| Alpha-2B adrenoreceptor \| Alpha-2BAR \| ADRA2L2 \| ADRA2RL2 \| Alpha-2 adrenergic receptor subtype C4 \| Alpha-2C adrenoceptor \| Alpha-2C adrenoreceptor \| Alpha-2CAR \| 3.1.4.12 \| 3.1.4.3 \| Acid sphingomyelinase \| ASM \| aSMase \| AGP 1 \| AGP1 \| OMD 1 \| Orosomucoid-1 \| AGP 2 \| AGP2 \| OMD 2 \| Orosomucoid-2 \| 5-HT-6 \| 5-HT6 \| Serotonin receptor 6 \| 5-HT-7 \| 5-HT-X \| 5-HT7 \| Serotonin receptor 7 \| AXOR35 \| G-protein coupled receptor 105 \| GPCR105 \| GPRv53 \| H4R \| HH4R \| Pfi-013 \| SP9144 \| CALM \| CAM \| CAM1 \| CAM2 \| CAMB \| CALML2 \| CAM3 \| CAMC \| CAMIII \| 1.14.14.- \| Cholesterol 25-hydroxylase \| CYP2DL1 \| CYPIID6 \| Cytochrome P450-DB1 \| Debrisoquine 4-hydroxylase \| 1.14.14.1 \| Cholesterol 25-hydroxylase \| CYPIA2 \| Cytochrome P(3)450 \| Cytochrome P450 4 \| Cytochrome P450-P3 \| Hydroperoxy icosatetraenoate dehydratase \| 1.14.14.1 \| 4-nitrophenol 2-hydroxylase \| CYP2E \| CYPIIE1 \| Cytochrome P450-J \| 1,4-cineole 2-exo-monooxygenase \| 1,8-cineole 2-exo-monooxygenase \| 1.14.14.1 \| Albendazole monooxygenase (sulfoxide-forming) \| Albendazole sulfoxidase \| Cholesterol 25-hydroxylase \| CYP3A3 \| CYPIIIA3 \| CYPIIIA4 \| Cytochrome P450 3A3 \| Cytochrome P450 HLp \| Cytochrome P450 NF-25 \| Cytochrome P450-PCN1 \| Nifedipine oxidase \| Quinine 3-monooxygenase \| 3.1.1.8 \| Acylcholine acylhydrolase \| Butyrylcholine esterase \| CHE1 \| Choline esterase II \| Pseudocholinesterase \| ATP-binding cassette sub-family B member 1 \| MDR1 \| Multidrug resistance protein 1 \| P-glycoprotein 1 \| PGY1 \| Phospholipid transporter ABCB1 \| 7.6.2.- \| ATP-binding cassette sub-family B member 11 \| BSEP	[ "Apo Chlorpromazine", "Apo Chlorpromazine", "Apo Chlorpromazine", "Chlorprom Tab 100mg", "Chlorprom Tab 25mg", "Chlorprom Tab 50mg", "Chlorpromanyl 20 Syr", "Chlorpromanyl 40 Drops Syr 44.5mg/ml", "Chlorpromazine", "Chlorpromazine", "Chlorpromazine", "Chlorpromazine", "Chlorpromazine", "Chlorpromazine", "Chlorpromazine", "Chlorpromazine", "Chlorpromazine", "Chlorpromazine", "Chlorpromazine", "Chlorpromazine", "Chlorpromazine", "Chlorpromazine", "Chlorpromazine", "Chlorpromazine", "Chlorpromazine", "Chlorpromazine", "Chlorpromazine Hci", "Chlorpromazine Hci", "Chlorpromazine Hci", "Chlorpromazine HCl Inj 25mg/ml USP", "Chlorpromazine HCl Inj 27.9mg/ml", "Chlorpromazine HCl Inj USP", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine hydrochloride", "Chlorpromazine hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine hydrochloride", "Chlorpromazine hydrochloride", "Chlorpromazine hydrochloride", "Chlorpromazine hydrochloride", "Chlorpromazine hydrochloride", "Chlorpromazine hydrochloride", "Chlorpromazine hydrochloride", "Chlorpromazine hydrochloride", "Chlorpromazine hydrochloride", "Chlorpromazine hydrochloride", "Chlorpromazine hydrochloride", "Chlorpromazine hydrochloride", "Chlorpromazine hydrochloride", "Chlorpromazine hydrochloride", "Chlorpromazine hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "ChlorproMAZINE Hydrochloride", "ChlorproMAZINE Hydrochloride", "ChlorproMAZINE Hydrochloride", "ChlorproMAZINE Hydrochloride", "ChlorproMAZINE Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine hydrochloride", "Chlorpromazine hydrochloride", "Chlorpromazine hydrochloride", "Chlorpromazine hydrochloride", "Chlorpromazine hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "ChlorproMAZINE Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "ChlorproMAZINE Hydrochloride", "ChlorproMAZINE Hydrochloride", "ChlorproMAZINE Hydrochloride", "ChlorproMAZINE Hydrochloride", "ChlorproMAZINE Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine Hydrochloride", "Chlorpromazine hydrochloride", "Chlorpromazine hydrochloride", "Chlorpromazine hydrochloride", "Chlorpromazine hydrochloride", "Chlorpromazine hydrochloride", "Chlorpromazine hydrochloride", "Chlorpromazine Hydrochloride Injection", "Chlorpromazine Tab 25mg", "Chlorpromazine Tablets B.P. 100mg", "Chlorpromazine Tablets B.P. 25mg", "Chlorpromazine Tablets B.P. 50mg", "Largactil 100", "Largactil 25", "Largactil 50", "Largactil Drops 40mg/ml", "Largactil Sup 100mg", "Novo-chlorpromazine 200mg", "Novo-chlorpromazine Tab 10mg", "Teva-chlorpromazine", "Teva-chlorpromazine", "Teva-chlorpromazine", "Thorazine", "Thorazine", "Thorazine", "Thorazine", "Thorazine", "Thorazine", "Thorazine", "Thorazine", "Thorazine", "Thorazine", "Thorazine" ]	[ "Aminazine", "Chlorderazin", "Chloropromazine", "Chlorpromados", "Chlorpromanyl", "Contomin", "Largactil" ]	[]	[ "P14416", "P21728", "P08908", "P28223", "P35348", "P35368", "P35367", "Q12809", "P21728", "P21918", "P35462", "P21917", "P21918", "P28335", "P28223", "P41595", "P28335", "P35348", "P35368", "P25100", "P08913", "P18089", "P18825", "P11229", "P20309", "P17405", "P02763", "P19652", "P50406", "P34969", "Q9H3N8", "P0DP23", "P0DP24", "P0DP25" ]	[ "P10635", "P05177", "P05181", "P08684", "P06276" ]	[ "P02768" ]	[ "P08183", "O95342" ]
DB00478	Rimantadine	An RNA synthesis inhibitor that is used as an antiviral agent in the prophylaxis and treatment of influenza.	solid	For the prophylaxis and treatment of illness caused by various strains of influenza A virus in adults.	Rimantadine, a cyclic amine, is a synthetic antiviral drug and a derivate of adamantane, like a similar drug amantadine. Rimantadine is inhibitory to the in vitro replication of influenza A virus isolates from each of the three antigenic subtypes (H1N1, H2H2 and H3N2) that have been isolated from man. Rimantadine has little or no activity against influenza B virus. Rimantadine does not appear to interfere with the immunogenicity of inactivated influenza A vaccine.	The mechanism of action of rimantadine is not fully understood. Rimantadine appears to exert its inhibitory effect early in the viral replicative cycle, possibly inhibiting the uncoating of the virus. The protein coded by the M2 gene of influenza A may play an important role in rimantadine susceptibility.	Well absorbed, with the tablet and syrup formulations being equally absorbed after oral administration.	Following oral administration, rimantadine is extensively metabolized in the liver with less than 25% of the dose excreted in the urine as unchanged drug. Glucuronidation and hydroxylation are the major metabolic pathways.	Oral LD<sub>50</sub> in rats is 640 mg/kg. Overdoses of a related rug, amantadine, have been reported with adverse reactions consisting of agitation, hallucinations, cardiac arrhythmia and death.	25 to 30 hours in young adults (22 to 44 years old). Approximately 32 hours in elderly (71 to 79 years old) and in patients with chronic liver disease. Approximately 13 to 38 hours in children (4 to 8 years old).	Approximately 40% over typical plasma concentrations.	Following oral administration, rimantadine is extensively metabolized in the liver with less than 25% of the dose excreted in the urine as unchanged drug.	null	null	Organic compounds	Organic nitrogen compounds	Organonitrogen compounds	Amines	[ "approved", "investigational" ]	[ "J05AC", "J05A", "J05", "J" ]	[ "Human Influenza A Virus" ]	[ { "cost": "1.94", "description": "Levaquin i.v. 25 mg/ml vial", "unit": "ml" }, { "cost": "2.4", "description": "Flumadine 100 mg tablet", "unit": "tablet" }, { "cost": "2.44", "description": "Rimantadine hcl 100 mg tablet", "unit": "tablet" }, { "cost": "12.21", "description": "Quixin 0.5% eye drops", "unit": "ml" }, { "cost": "14.09", "description": "Levaquin 250 mg tablet", "unit": "tablet" }, { "cost": "14.69", "description": "Levaquin 500 mg tablet", "unit": "tablet" }, { "cost": "15.71", "description": "Iquix 1.5% eye drops", "unit": "ml" }, { "cost": "27.51", "description": "Levaquin 750 mg leva-pak tablet", "unit": "tablet" }, { "cost": "27.51", "description": "Levaquin 750 mg tablet", "unit": "tablet" }, { "cost": "42.69", "description": "Levofloxacin hemihydr 100% powder", "unit": "g" }, { "cost": "0.44", "description": "Levaquin 500 mg/100 ml d5w", "unit": "ml" } ]	[]	alpha-Methyl-1-adamantanemethylamine \| alpha-Methyladamantanemethylamine \| Rimantadina \| Rimantadine \| Rimantadinum \| Proton channel protein M2	[ "Flumadine", "Flumadine", "Flumadine", "Flumadine", "Rimantadine Hydrochloride", "Rimantadine Hydrochloride", "Rimantadine Hydrochloride", "Rimantadine Hydrochloride", "Rimantadine Hydrochloride", "Rimantadine Hydrochloride", "Rimantadine Hydrochloride", "Rimantalist" ]	[]	[ "Rimantalist" ]	[]	[]	[]	[]
DB00480	Lenalidomide	Lenalidomide (previously referred to as CC-5013) is an immunomodulatory drug with potent antineoplastic, anti-angiogenic, and anti-inflammatory properties.[A228553] It is a 4-amino-glutamyl analogue of [thalidomide] [A228543] and like thalidomide, lenalidomide exists as a racemic mixture of the active S(-) and R(+) forms.[A228708] However, lenalidomide is much safer and potent than thalidomide, with fewer adverse effects and toxicities.[A714, A228543] Thalidomide and its analogues, including lenalidomide, are referred to as immunomodulatory imide drugs (also known as cereblon modulators), which are a class of immunomodulatory drugs that contain an imide group. Lenalidomide works through various mechanisms of actions that promote malignant cell death and enhance host immunity.[A228708] Available as oral capsules, lenalidomide is approved by the FDA and EU for the treatment of multiple myeloma, myelodysplastic syndromes, mantle cell lymphoma, follicular lymphoma, and marginal zone lymphoma in selected patients.[L16028] Due to severe teratogenicity, pregnancy must be excluded before the start of treatment and patients must enroll in the lenalidomide Risk Evaluation and Mitigation Strategy (REMS) program to ensure contraception adherence.[A228708]	solid	Lenalidomide is indicated for the treatment of adult patients with multiple myeloma (MM) in combination with dexamethasone. It is also indicated as maintenance therapy in multiple myeloma following autologous hematopoietic stem cell transplantation (auto-HSCT). It is indicated for the treatment of adult patients with transfusion-dependent anemia due to low- or intermediate-1-risk myelodysplastic syndromes (MDS) associated with a deletion 5q cytogenetic abnormality with or without additional cytogenetic abnormalities. Lenalidomide is indicated for the treatment of adult patients with mantle cell lymphoma (MCL) whose disease has relapsed or progressed after two prior therapies, one of which included bortezomib. In combination with a rituximab product, lenalidomide is indicated for the treatment of adult patients with previously treated follicular lymphoma (FL) or previously treated marginal zone lymphoma (MZL).[L16028]	In hematological malignancies, the immune system is deregulated in the form of altered cytokine networks in the tumour microenvironment, defective T cell regulation of host-tumour immune interactions, and diminished NK cell activity.[A228543] Lenalidomide is an immunomodulatory agent with antineoplastic, antiangiogenic, and anti-inflammatory properties.[A228628] Lenalidomide exerts direct cytotoxicity by increasing apoptosis and inhibiting the proliferation of hematopoietic malignant cells.[A228708] It delays tumour growth in nonclinical hematopoietic tumour models _in vivo_, including multiple myeloma.[L16028] Lenalidomide also works to limit the invasion or metastasis of tumour cells and inhibits angiogenesis.[A228708] Lenalidomide also mediates indirect antitumour effects via its immunomodulatory actions: it inhibits the production of pro-inflammatory cytokines, which are implicated in various hematologic malignancies. Lenalidomide enhances the host immunity by stimulating T cell proliferation and enhancing the activity of natural killer (NK) cells.[A713, A228703, A228708] Lenalidomide is about 100–1000 times more potent in stimulating T cell proliferation than [thalidomide].[A228543] _In vitro_, it enhances antibody-dependent cell-mediated cytotoxicity (ADCC), which is even more pronounced when used in combination with rituximab.[L16028] Due to its anti-inflammatory properties, lenalidomide has been investigated in the context of inflammatory and autoimmune diseases, such as amyotrophic lateral sclerosis.[A229418]	Lenalidomide is a drug with multiple mechanisms of action. Lenalidomide exerts immunomodulating effects by altering cytokine production, regulating T cell co-stimulation, and enhancing the NK cell-mediated cytotoxicity.[A228543] Lenalidomide directly inhibits the cullin ring E3 ubiquitin ligase complex: upon binding to cereblon, a substrate adaptor of the complex, lenalidomide modulates substrate specificity of the complex to recruit substrate proteins of the ligase, including Ikaros (IKZF1), Aiolos (IKZF3), and CK1α.[L16028] These substrates are then tagged for ubiquitination and subsequent proteasomal degradation. IKZF1 and IKZF3 are B-cell transcription factors that are essential for B-cell differentiation and survival of malignant cells. IKZF3 also regulates the expression of interferon regulatory factor 4 (IRF4), which is a transcription factor that regulates the aberrant myeloma-specific gene. The immunomodulatory actions of lenalidomide can be partly explained by the degradation of IKZF3, since it is a repressor of the interleukin 2 gene (IL2): as lenalidomide decreases the level of IKZF3, the production of IL-2 increases, thereby increasing the proliferation of natural killer (NK), NKT cells, and CD4+ T cells.[A228703] Lenalidomide inhibits the production of pro-inflammatory cytokines TNF-α, IL-1, IL-6, and IL-12, while elevating the production of anti-inflammatory cytokine IL-10.[A228543] Lenalidomide acts as a T-cell co-stimulatory molecule that promotes CD3 T-cell proliferation and increases the production of IL-2 and IFN-γ in T lymphocytes, which enhances NK cell cytotoxicity and ADCC. It inhibits the expression and function of T-regulatory cells, which are often overabundant in some hematological malignancies.[A228708] Lenalidomide directly exerts antitumour effects by inhibiting the proliferation and inducing apoptosis of tumour cells. Lenalidomide triggers the activation of pro-apoptotic caspase-8, enhances tumour cell sensitivity to FAS-induced apoptosis, and downregulates NF-κB, an anti-apoptotic protein.[A228708] Independent of its immunomodulatory effects, lenalidomide mediates anti-angiogenic effects by inhibiting angiogenic growth factors released by tumour cells, such as vascular endothelial growth factor (VEGF), basic fibroblastic-growth factor (BFGF), and hepatocyte-growth factor. _In vitro_, lenalidomide inhibits cell adhesion molecules such as ICAM-1, LFA-1, β2 and β3 integrins, as well as gap-junction function, thereby preventing metastasis of malignant cells.[A228708]	Following oral administration, lenalidomide is rapidly absorbed with high bioavailability.[A228628] It has a T<sub>max</sub> ranging from 0.5 to six hours. Lenalidomide exhibits a linear pharmacokinetic profile, with its AUC and C<sub>max</sub> increasing proportionally with dose. Multiple dosing does not result in drug accumulation.[L16028] In healthy male subjects, the C<sub>max</sub> was 413 ± 77 ng/ml and the AUC<sub>infinity</sub> was 1319 ± 162 h x ng/ml.[A228628]	Lenalidomide is not subject to extensive hepatic metabolism involving CYP enzymes and metabolism contributes to a very minor extent to the clearance of lenalidomide in humans. Lenalidomide undergoes hydrolysis in human plasma to form 5-hydroxy-lenalidomide and N-acetyl-lenalidomide.[A228628] Unchanged lenalidomide is the predominant circulating drug form, with metabolites accounting for less than five percent of the parent drug levels in the circulation.[L16028]	The lowest lethal dose (LDLo) in rats is >2000 mg/kg following oral administration and >40 mg/kg following intravenous administration.[L31613] The oral Lowest published toxic dose (TDLo) in humans is 9 mg/kg/4W (intermittent).[L31623] There is limited clinical experience in managing lenalidomide overdose. In single-dose studies, healthy subjects have been exposed to doses up to 400 mg. In clinical trials, the dose-limiting toxicity was neutropenia and thrombocytopenia. Toxicities associated with lenalidomide, some leading to fatality, include embryo-fetal toxicity, neutropenia, thrombocytopenia, venous (deep vein thrombosis and pulmonary embolism) and arterial thromboembolic events (myocardial infarction and stroke), serious adverse cardiovascular reactions, second primary malignancies, hepatotoxicity, severe cutaneous reactions, tumour lysis syndrome, tumour flare reaction, hypothyroidism, and hyperthyroidism.[L16028]	In healthy subjects, the mean half-life of lenalidomide is three hours in the clinically relevant dose range (5–50 mg).[A228628] Half-life can range from three to five hours in patients with multiple myeloma, myelodysplastic syndromes, or mantle cell lymphoma.[L16028]	_In vitro_, about 30% of lenalidomide was bound to plasma proteins.[L16028]	Lenalidomide is eliminated predominantly via urinary excretion in the unchanged form. Following oral administration of 25 mg of radiolabeled lenalidomide in healthy subjects, about 90% of the dose (4.59% as metabolites) was eliminated in urine and 4% of the dose (1.83% as metabolites) was eliminated in feces within ten days post-dose. Approximately 85% of the dose was excreted as lenalidomide in the urine within 24 hours.[L16028]	In healthy male subjects, the apparent volume of distribution was 75.8 ± 7.3 L.[A228628]	The renal clearance of lenalidomide exceeds the glomerular filtration rate.[L16028] In healthy male subjects, the oral clearance was 318 ± 41 mL/min.[A228628]	Organic compounds	Organoheterocyclic compounds	Isoindoles and derivatives	Isoindolines	[ "approved" ]	[ "L04AX", "L04A", "L04", "L" ]	[ "Humans and other mammals" ]	[ { "cost": "388.0", "description": "Revlimid 5 mg capsule", "unit": "capsule" }, { "cost": "406.05", "description": "Revlimid 10 mg capsule", "unit": "capsule" }, { "cost": "407.7", "description": "Revlimid 15 mg capsule", "unit": "capsule" }, { "cost": "411.71", "description": "Revlimid 25 mg capsule", "unit": "capsule" } ]	[ { "approved": "2009-09-01", "country": "Canada", "expires": "2023-04-13", "number": "2477301" }, { "approved": "2005-08-16", "country": "Canada", "expires": "2014-02-24", "number": "2342974" }, { "approved": "2000-04-04", "country": "United States", "expires": "2018-08-28", "number": "6045501" }, { "approved": "2001-11-13", "country": "United States", "expires": "2020-10-23", "number": "6315720" }, { "approved": "2003-05-13", "country": "United States", "expires": "2018-08-28", "number": "6561976" }, { "approved": "2003-05-13", "country": "United States", "expires": "2020-10-23", "number": "6561977" }, { "approved": "2004-06-29", "country": "United States", "expires": "2020-10-23", "number": "6755784" }, { "approved": "2005-06-21", "country": "United States", "expires": "2018-08-28", "number": "6908432" }, { "approved": "2012-06-19", "country": "United States", "expires": "2018-08-28", "number": "8204763" }, { "approved": "2012-11-20", "country": "United States", "expires": "2020-10-23", "number": "8315886" }, { "approved": "2014-01-07", "country": "United States", "expires": "2020-10-23", "number": "8626531" }, { "approved": "2013-11-19", "country": "United States", "expires": "2018-08-28", "number": "8589188" }, { "approved": "2008-12-23", "country": "United States", "expires": "2023-10-07", "number": "7468363" }, { "approved": "2001-08-28", "country": "United States", "expires": "2016-07-24", "number": "6281230" }, { "approved": "2013-09-10", "country": "United States", "expires": "2023-05-15", "number": "8530498" }, { "approved": "2003-04-29", "country": "United States", "expires": "2016-07-24", "number": "6555554" }, { "approved": "2007-03-13", "country": "United States", "expires": "2023-04-11", "number": "7189740" }, { "approved": "2011-06-28", "country": "United States", "expires": "2023-10-07", "number": "7968569" }, { "approved": "2013-03-26", "country": "United States", "expires": "2023-04-11", "number": "8404717" }, { "approved": "2014-02-11", "country": "United States", "expires": "2023-05-15", "number": "8648095" }, { "approved": "2014-06-03", "country": "United States", "expires": "2028-03-08", "number": "8741929" }, { "approved": "2015-08-11", "country": "United States", "expires": "2023-05-15", "number": "9101622" }, { "approved": "2015-08-11", "country": "United States", "expires": "2023-05-15", "number": "9101621" }, { "approved": "2015-06-16", "country": "United States", "expires": "2023-04-11", "number": "9056120" }, { "approved": "1997-06-03", "country": "United States", "expires": "2019-10-04", "number": "5635517" }, { "approved": "2006-10-10", "country": "United States", "expires": "2016-07-24", "number": "7119106" }, { "approved": "2008-12-16", "country": "United States", "expires": "2027-04-27", "number": "7465800" }, { "approved": "2010-12-21", "country": "United States", "expires": "2024-11-24", "number": "7855217" }, { "approved": "2012-10-16", "country": "United States", "expires": "2016-07-24", "number": "8288415" }, { "approved": "2016-07-19", "country": "United States", "expires": "2023-05-15", "number": "9393238" }, { "approved": "2013-07-23", "country": "United States", "expires": "2023-10-07", "number": "8492406" }, { "approved": "2015-10-13", "country": "United States", "expires": "2023-05-15", "number": "9155730" } ]	1-oxo-2-(2,6-dioxopiperidin-3-yl)-4-aminoisoindoline \| 3-(4-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione \| Lenalidomida \| Lenalidomide \| Cachectin \| TNF-a \| TNF-alpha \| TNFA \| TNFSF2 \| Tumor necrosis factor ligand superfamily member 2 \| ODF \| OPGL \| Osteoclast differentiation factor \| Osteoprotegerin ligand \| RANKL \| Receptor activator of nuclear factor kappa-B ligand \| TNF-related activation-induced cytokine \| TRANCE \| 7B4 antigen \| Vascular endothelial cadherin \| VE-cadherin \| 1.14.99.1 \| COX-2 \| COX2 \| Cyclooxygenase-2 \| PGH synthase 2 \| PGHS-2 \| PHS II \| Prostaglandin H2 synthase 2 \| Prostaglandin-endoperoxide synthase 2 \| ATP-binding cassette sub-family B member 1 \| MDR1 \| Multidrug resistance protein 1 \| P-glycoprotein 1 \| PGY1 \| Phospholipid transporter ABCB1	[ "Apo-lenalidomide", "Apo-lenalidomide", "Apo-lenalidomide", "Apo-lenalidomide", "Apo-lenalidomide", "Apo-lenalidomide", "Eugia-lenalidomide", "Eugia-lenalidomide", "Eugia-lenalidomide", "Eugia-lenalidomide", "Eugia-lenalidomide", "Eugia-lenalidomide", "Jamp Lenalidomide", "Jamp Lenalidomide", "Jamp Lenalidomide", "Jamp Lenalidomide", "Jamp Lenalidomide", "Jamp Lenalidomide", "Lenalidomide", "Lenalidomide", "Lenalidomide", "Lenalidomide", "Lenalidomide", "Lenalidomide", "Lenalidomide", "Lenalidomide", "Lenalidomide", "Lenalidomide", "Lenalidomide", "Lenalidomide", "Lenalidomide", "Lenalidomide", "Lenalidomide", "Lenalidomide", "Lenalidomide", "Lenalidomide", "Lenalidomide", "Lenalidomide", "Lenalidomide", "Lenalidomide", "Lenalidomide", "Lenalidomide", "Lenalidomide", "Lenalidomide", "Lenalidomide", "Lenalidomide", "Lenalidomide", "Lenalidomide", "Lenalidomide", "Lenalidomide", "Lenalidomide", "Lenalidomide", "Lenalidomide", "Lenalidomide", "Lenalidomide", "Lenalidomide", "Lenalidomide", "Lenalidomide", "Lenalidomide", "Lenalidomide", "Lenalidomide", "Lenalidomide", "Lenalidomide", "Lenalidomide", "Lenalidomide", "Lenalidomide", "Lenalidomide", "Lenalidomide", "Lenalidomide", "Lenalidomide", "Lenalidomide", "Lenalidomide", "Lenalidomide", "Lenalidomide", "Lenalidomide", "Lenalidomide", "Lenalidomide", "Lenalidomide", "Lenalidomide", "Lenalidomide", "Lenalidomide", "Lenalidomide", "Lenalidomide", "Lenalidomide", "Lenalidomide", "Lenalidomide", "Lenalidomide", "Lenalidomide", "Lenalidomide", "Lenalidomide", "Lenalidomide", "Lenalidomide", "Lenalidomide", "Lenalidomide", "Lenalidomide", "Lenalidomide", "Lenalidomide", "Lenalidomide Accord", "Lenalidomide Accord", "Lenalidomide Accord", "Lenalidomide Accord", "Lenalidomide Accord", "Lenalidomide Accord", "Lenalidomide Accord", "Lenalidomide Accord", "Lenalidomide Accord", "Lenalidomide Accord", "Lenalidomide Accord", "Lenalidomide Accord", "Lenalidomide Accord", "Lenalidomide Accord", "Lenalidomide Krka", "Lenalidomide Krka", "Lenalidomide Krka", "Lenalidomide Krka", "Lenalidomide Krka", "Lenalidomide Krka", "Lenalidomide Krka", "Lenalidomide Krka", "Lenalidomide Krka", "Lenalidomide Krka", "Lenalidomide Krka", "Lenalidomide Krka", "Lenalidomide Krka", "Lenalidomide Krka", "Lenalidomide Krka D.D.", "Lenalidomide Krka D.D.", "Lenalidomide Krka D.D.", "Lenalidomide Krka D.D.", "Lenalidomide Krka D.D.", "Lenalidomide Krka D.D.", "Lenalidomide Krka D.D.", "Lenalidomide Krka D.D.", "Lenalidomide Krka D.D.", "Lenalidomide Krka D.D.", "Lenalidomide Krka D.D.", "Lenalidomide Krka D.D.", "Lenalidomide Krka D.D.", "Lenalidomide Krka D.D.", "Lenalidomide Krka D.D. Novo Mesto", "Lenalidomide Krka D.D. Novo Mesto", "Lenalidomide Krka D.D. Novo Mesto", "Lenalidomide Krka D.D. Novo Mesto", "Lenalidomide Krka D.D. Novo Mesto", "Lenalidomide Krka D.D. Novo Mesto", "Lenalidomide Krka D.D. Novo Mesto", "Lenalidomide Krka D.D. Novo Mesto", "Lenalidomide Krka D.D. Novo Mesto", "Lenalidomide Krka D.D. Novo Mesto", "Lenalidomide Krka D.D. Novo Mesto", "Lenalidomide Krka D.D. Novo Mesto", "Lenalidomide Krka D.D. Novo Mesto", "Lenalidomide Krka D.D. Novo Mesto", "Lenalidomide Mylan", "Lenalidomide Mylan", "Lenalidomide Mylan", "Lenalidomide Mylan", "Lenalidomide Mylan", "Lenalidomide Mylan", "Lenalidomide Mylan", "Lenalidomide Mylan", "Lenalidomide Mylan", "Lenalidomide Mylan", "Lenalidomide Mylan", "Lenalidomide Mylan", "Lenalidomide Mylan", "Lenalidomide Mylan", "Lenalidomide Mylan", "Lenalidomide Mylan", "Lenalidomide Mylan", "Lenalidomide Mylan", "Lenalidomide Mylan", "Lenalidomide Mylan", "Lenalidomide Mylan", "Lenalidomide Mylan", "Lenalidomide Mylan", "Lenalidomide Mylan", "Lenalidomide Mylan", "Lenalidomide Mylan", "Nat-lenalidomide", "Nat-lenalidomide", "Nat-lenalidomide", "Nat-lenalidomide", "Nat-lenalidomide", "Nat-lenalidomide", "Nat-lenalidomide", "Reddy-lenalidomide", "Reddy-lenalidomide", "Reddy-lenalidomide", "Reddy-lenalidomide", "Reddy-lenalidomide", "Reddy-lenalidomide", "Revlimid", "Revlimid", "Revlimid", "Revlimid", "Revlimid", "Revlimid", "Revlimid", "Revlimid", "Revlimid", "Revlimid", "Revlimid", "Revlimid", "Revlimid", "Revlimid", "Revlimid", "Revlimid", "Revlimid", "Revlimid", "Revlimid", "Revlimid", "Revlimid", "Revlimid", "Revlimid", "Revlimid", "Revlimid", "Revlimid", "Sandoz Lenalidomide", "Sandoz Lenalidomide", "Sandoz Lenalidomide", "Sandoz Lenalidomide", "Sandoz Lenalidomide", "Sandoz Lenalidomide", "Taro-lenalidomide", "Taro-lenalidomide", "Taro-lenalidomide", "Taro-lenalidomide", "Taro-lenalidomide", "Taro-lenalidomide", "Teva-lenalidomide", "Teva-lenalidomide", "Teva-lenalidomide", "Teva-lenalidomide", "Teva-lenalidomide", "Teva-lenalidomide" ]	[ "Ladevina", "Lenangio" ]	[]	[ "P01375", "Q96SW2", "O14788", "P33151", "P35354" ]	[]	[]	[ "P08183" ]
DB00481	Raloxifene	Raloxifene is a second generation selective estrogen receptor modulator (SERM) that mediates anti-estrogenic effects on breast and uterine tissues, and estrogenic effects on bone, lipid metabolism, and blood coagulation.[A4979,T28] Exhibiting tissue-specific effects distinct from [estradiol], raloxifene is the first of the benzothiophene group of antiestrogens to be labelled a SERM.[A4977] Available in many countries worldwide, raloxifene was initially approved by the FDA in December, 1997 under the market name Evista® for the management and prevention of osteoporosis in postmenopausal women and reduction in risk for invasive breast cancer in postmenopausal women with osteoporosis or those who are at high risk for invasive breast cancer. However, it has a negligible effect on altering the development and progression of breast cancer itself.[label] The most common causes of osteoporosis include postmenopausal deficiency of estrogen and age-related deterioration in bone homeostasis. Due to the risk of bone fractures that may lead to morbidities and reduced quality of life, the management of osteoporosis in postmenopausal women with the use of therapeutic agents in addition to concurrent therapies is critical. Due to the decline in estrogen levels in postmenopausal osteoporosis, hormone replacement therapy (HRT), such as estradiol, has been used to ameliorate the condition. However, due to the off-target actions by HRT, newer non-hormonal agents such as raloxifene and [tamoxifen] have been developed to reduce adverse events through selective pharmacological actions on tissue-specific therapeutic targets.[T28] The main effects of raloxifene are to preserve the bone mineral density and decrease the risk of breast cancer in postmenopausal women. Compared to estrogen and tamoxifen, raloxifene was not associated with an increased risk of uterine cancer and it does not cause endometrial proliferation.[A716] Although rare, there was an increased risk of venous thromboembolism during clinical trials of postmenopausal women receiving raloxifene. In addition, a clinical study consisting of postmenopausal women with documented coronary heart disease or at increased risk for coronary events showed an increased risk for fatal stroke with raloxifene therapy compared to placebo.[label] It is strongly advised that the risk-benefit ratio is considered before starting raloxifene therapy in women at risk of thromboembolic disease or strokes, such as the prior history of stroke, transient ischemic attack, atrial fibrillation, hypertension, or cigarette smoking.[label]	solid	Indicated for the prevention and treatment of osteoporosis in postmenopausal women, as well as prevention and treatment of corticosteroid-induced bone loss.[label] Indicated for the reduction in the risk of invasive breast cancer in postmenopausal women with osteoporosis or postmenopausal women with a high risk for invasive breast cancer.[label]	Raloxifene belongs to the selective estrogen receptor modulator (SERM) drug class that exhibits estrogenic effects on bone and lipid metabolism while mediating anti-estrogenic effects on uterine endometrium and breast tissues.[A4977] On skeletal tissues, raloxifene stimulates bone-depositing osteoblasts and inhibits bone-resorbing osteoclasts[T28] to augument bone mineral density.[A4977] Raloxifene produces estrogen-like effects on bone, reducing the resorption of bone and increasing bone mineral density in postmenopausal women, thus slowing the rate of bone loss.[label] In three randomized, placebo-controlled trials in Europe, postmenopausal women receiving raloxifene at variable doses of 30 to 150 mg daily demonstrated significant increases in bone mineral density in the lumbar spine, total hip, femoral neck and total body compared to placebo.[A4977] In the MORE and RUTH trials, there were fewer incidences of vertebral fractures in postmeopausal women receiving raloxifene compared to placebo.[A4979] In a eight-week study evaluating short-term effects of raloxifene in healthy postmenopausal women, there was a decrease in the bone turnover markers, such as serum alkaline phosphatase level, serum osteocalcin level and urinary calcium excretion.[A4977] Raloxifene was shown to inhibit estrogen-dependent proliferation of human breast cancer cells _in vitro_ and development of induced mammary tumors in rats _in vivo_.[A721] In adult female rats, raloxifene produced a greater regression of the mammary gland than [tamoxifen].[A721] The MORE trial was a multicenter, randomized, double-blind clinical trial that investigated the long-term effects of the drug therapy in European and American postmenopausal women receiving raloxifene for 40 months.[A719] Additionally, a reduction in the incidence of invasive breast cancer was also demonstrates in the CORE and RUTH trials.[A4979] Study findings demonstrated that compared to placebo, the risk of invasive breast cancer was decreased by 76% among postmenopausal women with osteoporosis. There was a decrease in the risk of estrogen receptor-positive breast cancer by 90% but there was no increase in the risk of endometrial cancer. Unlike hormone replacement therapy, raloxifene does not mediate proliferative or stimulatory effects on endometrial tissue. Findings from both animal and human studies demonstrated no significant changes in the histologic appearance of the endometrium.[A4977] Raloxifene promotes estrogen-like effects on lipid metabolism. In a European trial that evaluated lipid profiles following raloxifene therapy over the 24-month period, there were significant decreases in the serum concentrations of total and low-density lipoprotein (LDL) cholesterol over a 24-month period of raloxifene therapy.[A4977] Raloxifene is not associated with causing alterations in the serum levels of HDL cholesterol or triglycerides.[A4977] As the HDL choesterol level is considered a strong inverse predictor of cardiovascular disease in women, the cardioprotective effects of raloxifene were questioned. Due to limited data on the long-term trials, it is not possible to determine whether the small lipid effects produced by raloxifene correlate with a smaller degree of cardioprotective activity compared with hormone replacement therapy.[A4977]	Raloxifene is a selective estrogen receptor modulator that acts as both an estrogen agonist and antagonist via differential effects on the tissue-specific estrogen receptors. Based on the findings of competitive binding assays, raloxifene displays binding affinity that is similar to that of [estradiol][A721], the predominant circulating estrogen.[A178861] Estrogens play variable roles at different tissues in females, including the bone, breasts, uterus and liver, by binding to the steroid nuclear hormone receptors, Estrogen Receptor alpha (ERα) or Estrogen Receptor beta (ERβ).[A178861] These receptors are normally bound to the Heat Shock Protein 90 (Hsp90) when unbound to the ligand. Ligand binding induces a conformational change in the receptor that promotes dissociation of the receptor from Hsp90, dimerization and translocation into the nucleus. This movement into the nucleus allows the receptor to bind to genomic locations based on sequence recognition of the DNA binding domain, also known as the Estrogen Response Elements (EREs).[A178861] In bones, endogenous estrogens normally modulate multiple DNA response elements, including the gene-encoding transforming growth factor-β3 (TGF-β3), which is a cytokine embedded in the bone matrix.[T28] TGF-β3 plays an important role in bone remodelling[A178756] by working with other cytokines to induce production of osteoblasts, such as IL-6[A720], and attenuate the activity of osetoclasts. Estrogens typically maintain the bone integrity by inhibiting the cytokines that recruit osteoclasts and oppose the bone-resorbing, Ca2+-mobilizing action of parathyroid hormone. In contrast, estrogens promote osteoblast proliferation, augment the production of TGF-β3 and bone morphogenic proteins, and inhibit apoptosis.[T28] Mimicking the action of endogenous estrogen in bone tissues, raloxifene binds to the estrogen receptor to influence gene transcription through interactions with the estrogen response element (ERE) and a distinct DNA target, the raloxifene response element (RRE).[A722] It occupies the same ER ligand binding site as estrogen.[A724] Upon binding, raloxifene induces a conformational change of the receptor, allowing mediation of direct binding to transcriptional elements by accessory proteins. Increased expression of bone matrix proteins, such as alkaline phosphatase, osteonectin, osteocalcin and collagen may be seen.[A722] The agonistic or antagonistic action of raloxifene depends on the extent of recruitment of coactivators and corepressors to estrogen receptor (ER) target gene promotors.[label] In breast tissues, raloxifene acts as an estrogen receptor antagonist to attenuate the estrogen-dependent proliferative effects of epithelial cell expansion. In addition to the antiproliferative effects, raloxifene prevents the production of cytokines and recruitment of macrophages and lymphocytes into tumor mass.[A178921]	Raloxifene is well absorbed from the gastrointestinal tract, with approximately 60% fo the drug being absorbed following oral administration.[T28] Due to the extensive first-pass hepatic metabolism that involves glucuronide conjugation, the absolute oral bioavailability of raloxifene is about 2%.[T28] Following oral ingestion of a single dose or multiple dose of raloxifen in healthy postmenopausal women, the mean peak plasma concentrations (Cmax) were 0.50 and 1.36 ng/mL, respectively, and the AUC values were 27.2 and 24.2 ngxhr/mL, respectively. The time to reach Cmax following a single or multiple oral doses were 27.7 and 32.5 hours, respectively.[label] Although not clinically significant, oral ingestion of raloxifene with high-fat meals is thought to increase the systemic bioavailability of the drug[A4977] by increasnig the peak plasma concentrations (Cmax) and AUC by 28% and 16%, respectively.[label]	Raloxifene is reported to undergo metabolism in the intestines and liver devoid of cytochrome P450 pathway.[A4977] It is extensively metabolized, where less than 1% of the total dose exists as unchanged compound.[label] It mainly undergoes first-pass metabolism to form glucuronide conjugates, raloxifene-4'-glucuronide (raloxifene-4'-β-glucuronide), raloxifene-6-glucuronide (raloxifene-6-β-glucuronide), and raloxifene-6,4'-diglucuronide. No other metabolites have been detected in human plasma. The terminal log-linear portions of the plasma concentration curves for raloxifene and the glucuronides are generally parallel. This is consistent with interconversion of raloxifene and the glucuronide metabolites.[label]	LD<sub>50</sub> and Overdose The oral LD<sub>50</sub> value in rats is > 5000 mg/kg, which is about 810 times the human dose.[MSDS] In monkeys, no mortality was seen after a single oral dose of 1000 mg/kg.[label] No cases of raloxifene overdose have been reported during clinical trials. A rare postmarketing report of a non-fatal overdose after oral ingestion of 1.5 g has been reported. Common adverse events of leg cramps, hot flushes, and dizziness have been reported with the use of raloxifene at doses of greater than 180 mg. More serious adverse event of venous thromboembolic events were observed with raloxifene.[A721] Two 18-month-old children accidentally ingested 180 mg of raloxifene and symptoms of ataxia, dizziness, vomiting, rash, diarrhea, tremor, flushing, and elevated alkaline phosphatase levels were reported. There is no known antidote for raloxifene. [label] Nonclinical Toxicology In a two-year mouse carcinogenicity study at raloxifene doses that are higher than the human therapeutic doses, there was an increased incidence of benign and malignant ovarian tumors of granulosa or theca cell origin. Another study showed an increased incidence of testicular interstitial cell tumors, prostatic adenomas, adenocarcinomas, and prostatic leiomyoblastoma in male mice receiving doses higher than human therapeutic doses. There was no evidence of the genotoxic potential of raloxifene in bacterial mutagenicity assays, _in vitro_ rat DNA assays, or other _in vitro_ rodent cell line assays. When assessing effects on the reproductive system of male and female rats, raloxifene caused lack of pregnancy and disruptions in estrous cycles and inhibited ovulation at dose of 0.1 to 10 mg/kg/day. Administration of raloxifene during the preimplantation period at doses greater than 0.1 mg/kg resulted in delayed and disrupted embryo implantation, further leading to prolonged gestation and reduced litter size. There were no effects on sperm production or quality or reproductive performance in male rats. The effects on the fertility by raloxifene were reversible.[label] Use in special populations The use of raloxifene in pregnant or nursing women is not advised. Although there are no specific dosing adjustment guidelines, caution should be undertaken when administering raloxifene in geriatric patients or patients with renal or hepatic impairment.[label]	The average plasma elimination half-life of raloxifene ranges from 27 to 32 hours.[A4977,T28] The prolonged half-life has been attributed to the drug's reversible systemic metabolism and significant enterohepatic cycling.[A4977]	About 95% of raloxifene and its glucuronide metabolites are bound to plasma proteins.[label] Although this is a relatively high protein binding profile, _in vitro_ studies suggest that raloxifene and its metabolites do not significantly interact with binding of highly protein-bound drugs.[A4977] FDA Label still advises patients to use raloxifene with caution co-administering with other highly protein-bound drugs.[label]	Raloxifene predominantly undergoes fecal excretion, with less than 0.2% of the dose being excreted in the urine as unchanged form of the compound and less than 6% of the dose being excreted as glucuronide conjugates. Co-administration with [cholestyramine], a bile acid sequestrant, was shown to reduce the enterohepatic recycling of raloxifene by 60%.[T28]	Following oral administration of single doses randing from 30 to 150 mg in postmenopausal women, the volume of distribution was about 2348 L/kg. Following oral administration of multiple doses, the value increased to 2853 L/kg. Raloxifene is widely distributed in the tissues. It is not known whether raloxifene is excreted in human milk.[label]	Following intravenous administration, raloxifene was shown to be cleared at a rate approximating hepatic blood flow. The apparent oral clearance is reported to be 44.1 L/kgxhr. The clearance can range from 40 to 60L/kgxhr following chronic dosing. In healthy postmenopausal women receiving multiple oral dose, the mean clearance was 47.4 L/kgxhr. Apparent clearance can be reduced by 56% in patients with hepatic impairment.[label]	Organic compounds	Organic oxygen compounds	Organooxygen compounds	Carbonyl compounds	[ "approved", "investigational" ]	[ "G03XC", "G03X", "G03", "G" ]	[ "Humans and other mammals" ]	[ { "cost": "4.37", "description": "Evista 60 mg tablet", "unit": "tablet" } ]	[ { "approved": "1995-02-28", "country": "United States", "expires": "2012-07-28", "number": "5393763" }, { "approved": "2006-10-24", "country": "Canada", "expires": "2015-09-15", "number": "2158400" }, { "approved": "1998-11-17", "country": "Canada", "expires": "2013-07-27", "number": "2101356" }, { "approved": "2002-10-01", "country": "United States", "expires": "2017-03-10", "number": "6458811" }, { "approved": "2005-05-17", "country": "United States", "expires": "2017-03-10", "number": "6894064" }, { "approved": "2004-09-28", "country": "United States", "expires": "2017-03-10", "number": "6797719" }, { "approved": "2011-10-04", "country": "United States", "expires": "2017-03-10", "number": "8030330" } ]	(2-(4-Hydroxyphenyl)-6-hydroxybenzo(b)thien-3-yl)(4-(2-(1-piperidinyl)ethoxy)phenyl)methanone \| Raloxifène \| Raloxifene \| Raloxifeno \| Raloxifenum \| ER \| ER-alpha \| ESR \| Estradiol receptor \| NR3A1 \| Nuclear receptor subfamily 3 group A member 1 \| ER-beta \| ESTRB \| NR3A2 \| Nuclear receptor subfamily 3 group A member 2 \| CAP-3 \| CAP3 \| Cytoplasmic antiproteinase 3 \| Peptidase inhibitor 9 \| PI-9 \| PI9 \| BCEI \| Breast cancer estrogen-inducible protein \| hP1.A \| PNR-2 \| Polypeptide P1.A \| Protein pS2 \| PS2 \| 1,4-cineole 2-exo-monooxygenase \| 1.14.13.- \| CYPIIB6 \| Cytochrome P450 IIB1 \| 1.14.14.1 \| CYPIIC8 \| Cytochrome P450 form 1 \| Cytochrome P450 IIC2 \| Cytochrome P450 MP-12 \| Cytochrome P450 MP-20 \| S-mephenytoin 4-hydroxylase \| 1.2.3.1 \| Aldehyde oxidase 1 \| AO \| Azaheterocycle hydroxylase \| 1.14.14.14 \| ARO1 \| CYAR \| CYP19 \| CYPXIX \| Cytochrome P-450AROM \| Cytochrome P450 19A1 \| Estrogen synthase \| 1,4-cineole 2-exo-monooxygenase \| 1,8-cineole 2-exo-monooxygenase \| 1.14.14.1 \| Albendazole monooxygenase (sulfoxide-forming) \| Albendazole sulfoxidase \| Cholesterol 25-hydroxylase \| CYP3A3 \| CYPIIIA3 \| CYPIIIA4 \| Cytochrome P450 3A3 \| Cytochrome P450 HLp \| Cytochrome P450 NF-25 \| Cytochrome P450-PCN1 \| Nifedipine oxidase \| Quinine 3-monooxygenase \| 2.4.1.17 \| Bilirubin-specific UDPGT isozyme 1 \| GNT1 \| hUG-BR1 \| UDP-glucuronosyltransferase 1-1 \| UDP-glucuronosyltransferase 1A isoform 1 \| UDPGT 1-1 \| UGT1 \| UGT1-01 \| UGT1.1 \| UGT11 \| UGT1A1 \| 2.4.1.17 \| GNT1 \| UDP-glucuronosyltransferase 1-10 \| UDP-glucuronosyltransferase 1-J \| UDPGT 1-10 \| UGT-1J \| UGT1 \| UGT1-10 \| UGT1.10 \| UGT110 \| UGT1A10 \| UGT1J \| 2.4.1.17 \| GNT1 \| UDP-glucuronosyltransferase 1-8 \| UDP-glucuronosyltransferase 1-H \| UDPGT 1-8 \| UGT-1H \| UGT1 \| UGT1-08 \| UGT1.8 \| UGT1*8 \| UGT1A8 \| UGT1H \| AGP 1 \| AGP1 \| OMD 1 \| Orosomucoid-1 \| Liver-specific organic anion transporter 1 \| LST-1 \| LST1 \| OATP-2 \| OATP-C \| OATP1B1 \| OATP2 \| OATPC \| Organic anion transporter SLC21A6 \| SLC21A6 \| SLCO1B1 \| Sodium-independent organic anion-transporting polypeptide 2 \| Solute carrier family 21 member 6 \| Liver-specific organic anion transporter 2 \| LST-2 \| LST2 \| OATP-8 \| OATP1B3 \| OATP8 \| Organic anion transporter 8 \| Organic anion-transporting polypeptide 8 \| SLC21A8 \| Solute carrier family 21 member 8 \| ATP-binding cassette sub-family B member 1 \| MDR1 \| Multidrug resistance protein 1 \| P-glycoprotein 1 \| PGY1 \| Phospholipid transporter ABCB1 \| 7.6.2.2 \| ABCP \| ATP-binding cassette sub-family G member 2 \| BCRP \| BCRP1 \| Breast cancer resistance protein \| CDw338 \| Mitoxantrone resistance-associated protein \| MXR \| Placenta-specific ATP-binding cassette transporter \| Urate exporter \| 7.6.2.- \| 7.6.2.2 \| 7.6.2.3 \| Canalicular multidrug resistance protein \| Canalicular multispecific organic anion transporter 1 \| CMOAT \| CMOAT1 \| CMRP \| MRP2 \| Multidrug resistance-associated protein 2 \| 7.6.2.- \| 7.6.2.2 \| 7.6.2.3 \| Canalicular multispecific organic anion transporter 2 \| CMOAT2 \| MLP2 \| MOAT-D \| MRP3 \| Multi-specific organic anion transporter D \| Multidrug resistance-associated protein 3 \| 7.6.2.- \| 7.6.2.2 \| 7.6.2.3 \| MOAT-B \| MOATB \| MRP/cMOAT-related ABC transporter \| MRP4 \| Multi-specific organic anion transporter B \| Multidrug resistance-associated protein 4	[ "Act Raloxifene", "Apo-raloxifene", "Evista", "Evista", "Evista", "Evista", "Evista", "Evista", "Evista", "Evista", "Evista", "Evista", "Jamp Raloxifene", "Optruma", "Optruma", "Optruma", "Optruma", "PMS-raloxifene", "Raloxifene", "Raloxifene", "Raloxifene", "Raloxifene Hydrochloride", "Raloxifene hydrochloride", "Raloxifene Hydrochloride", "Raloxifene Hydrochloride", "Raloxifene hydrochloride", "Raloxifene Hydrochloride", "Raloxifene hydrochloride", "Raloxifene Hydrochloride", "Raloxifene Hydrochloride", "Raloxifene hydrochloride", "Raloxifene Hydrochloride", "Raloxifene Hydrochloride", "Raloxifene hydrochloride", "Raloxifene Hydrochloride", "Raloxifene Hydrochloride", "Raloxifene Hydrochloride", "Raloxifene Hydrochloride", "Raloxifene Hydrochloride", "Raloxifene Hydrochloride", "Raloxifene Hydrochloride", "Raloxifene Hydrochloride", "Raloxifene hydrochloride", "Raloxifene hydrochloride", "Raloxifene Hydrochloride", "Raloxifene Hydrochloride", "Raloxifene Hydrochloride", "Raloxifene Hydrochloride", "Raloxifene hydrochloride", "Raloxifene hydrochloride", "Raloxifene Hydrochloride", "Raloxifene hydrochloride", "Raloxifene Hydrochloride", "Raloxifene Hydrochloride", "Raloxifene Hydrochloride", "Raloxifene Hydrochloride", "Raloxifene Hydrochloride", "Raloxifene Hydrochloride", "Raloxifene Hydrochloride", "Raloxifene Hydrochloride", "Raloxifene Hydrochloride", "Raloxifene hydrochloride", "Raloxifene Hydrochloride", "Raloxifene hydrochloride", "Raloxifene Hydrochloride", "Raloxifene hydrochloride", "Raloxifene Teva", "Raloxifene Teva", "Raloxifene Teva", "Teva-raloxifene" ]	[ "Keoxifene" ]	[]	[ "P03372", "Q92731", "P50453", "P04155" ]	[ "P20813", "P10632", "Q06278", "P11511", "P08684", "P22309", "Q9HAW8", "Q9HAW9" ]	[ "P02768", "P02763" ]	[ "Q9Y6L6", "Q9NPD5", "P08183", "Q9UNQ0", "Q92887", "O15438", "O15439" ]
DB00483	Gallamine triethiodide	A synthetic nondepolarizing blocking drug. The actions of gallamine triethiodide are similar to those of tubocurarine, but this agent blocks the cardiac vagus and may cause sinus tachycardia and, occasionally, hypertension and increased cardiac output. It should be used cautiously in patients at risk from increased heart rate but may be preferred for patients with bradycardia. (From AMA Drug Evaluations Annual, 1992, p198)	solid	For use as adjuncts to anesthesia to induce skeletal muscle relaxation and to facilitate the management of patients undergoing mechanical ventilation	Gallamine Triethiodide is a nondepolarizing neuromuscular blocking drug (NDMRD) used as an adjunct to anesthesia to induce skeletal muscle relaxation. The actions of gallamine triethiodide are similar to those of tubocurarine, but this agent blocks the cardiac vagus and may cause sinus tachycardia and, occasionally, hypertension and increased cardiac output. Muscle groups differ in their sensitivity to these types of relaxants with ocular muscles (controlling eyelids) being most sensitive, followed by the muscles of the neck, jaw, limbs and then abdomen. The diaphragm is the least sensitive muscle to NDMRDs. Although the nondepolarizing neuromuscular blocking drugs do not have the same adverse effects as succinylcholine, their onset of action is slower. They also have a longer duration of action, making them more suitable for maintaining neuromuscular relaxation during major surgical procedures.	It competes with acetylcholine (ACh) molecules and binds to muscarinic acetylcholine receptors on the post-synaptic membrane of the motor endplate. It acts by combining with the cholinergic receptor sites in muscle and competitively blocking the transmitter action of acetylcholine. It blocks the action of ACh and prevents activation of the muscle contraction process. It can also act on nicotinic presynaptic acetylcholine receptors which inhibits the release of ACh.	null	null	null	null	null	null	null	null	Organic compounds	Benzenoids	Phenol ethers	null	[ "approved" ]	[]	[ "Humans and other mammals" ]	[]	[]	Gallamin triethiodid \| Gallamine triethiodide \| Gallamini Triethiodidum \| Triéthiodure de Gallamine \| Trietioduro de galamina \| 3.1.1.7 \| AChE	[ "Flaxedil Inj 20mg/ml" ]	[ "Flaxedil", "Myraxan", "Sincurarina", "Tricuran" ]	[]	[ "P08172", "P22303", "Q15822", "P11229", "P08912" ]	[]	[]	[]
DB00484	Brimonidine	Brimonidine is an alpha-adrenergic agonist and 2-imidazoline derivative that was first introduced in 1996.[A178951] It is considered to be a third generation alpha-2 aadrenergic receptor agonist, since it displays preferential binding at alpha-2 adrenoceptors over alpha-1 receptors.[A179002] Brimonidine displays a higher selectivity toward the alpha-2 adrenergic receptors than [clonidine] or [apraclonidine], which are also alpha-2 adrenergic agonists.[A178969] Alpha-2 adrenergic agonists are members of the ocular hypotensive agent drug class that are used in the chronic treatment of glaucoma. Early treatment and management of glaucoma, which predominantly involves the lowering of intraocular pressure, is critical since glaucoma is considered to be a common cause of blindness worldwide.[A178948,A178969] Ophthalmically, brimonidine is used to lower intraocular pressure by reducing aqueous humor production and increasing uveoscleral outflow. Because it is oxidately stable, brimonidine is associated with fewer reports of ocular allergic reactions compared to other alpha-2 adrenergic agonists.[A178969] The ophthalmic solution of brimonidine was first approved by the FDA in 1996 as Alphagan [label] and brimonidine is the only selective alpha-adrenergic receptor agonist approved for chronic treatment in glaucoma.[A36674] Brimonidine is also found in ophthalmic solutions in combination with [brinzolamide] under the market name Simbrinza for the reduction in intraocular pressure. Unlike nonselective beta-blockers used in ocular hypertension, brimonidine is not associated with significantly adverse cardiopulmonary side effects.[A178945] Thus brimonidine is an effective and safe alternative to beta-blockers, in patients with, or at high risk for, cardiopulmonary disease.[A178948] The topical form of brimonidine was approved by the FDA in August 2013 for the symptomatic treatment of persistent facial erythema of rosacea in adults. It is marketed under the brand name Mirvaso.[L6535] Brimonidine is the first topical treatment approved for facial erythema of rosacea.[A178978]	solid	Opthalmic Indicated for lowering intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension [label] as monotherapy or combination product with [brinzolamide]. Topical Indicated for the treatment of persistent (non-transient) facial erythema of rosacea in adults 18 years of age or older.[L6535]	Brimonidine is a highly selective alpha-2 adrenergic receptor agonist that is 1000-fold more selective for the alpha2-adrenergic receptor than the alpha1-adrenergic receptor.[L6544] This characteristic gives the drug some therapeutic advantages, since it reduces the risk of systemic side effects, such as systemic hypotension, bradycardia, and sedation. In addition, there is a reduction in the risk for developing alpha-1 mediated ocular unwanted effects, such as conjunctival blanching, mydriasis, and eyelid retraction.[A179002] However, despite high alpha-2 receptor specificity, brimonidine may still produce alpha-1 adrenoceptor-mediated ocular effects, such as conjunctival vasoconstriction.[A178969] Brimonidine has a peak ocular hypotensive effect occurring at two hours post-dosing.[label] In a randomized, double-blind clinical study, ocular administration of 0.2% brimonidine in healthy volunteers resulted in a 23% reduction of mean intraocular pressure from baseline at 3 hours following administration.[A178951] In comparative studies consisting of patients with open-angle glaucoma or ocular hypertension, the ocular hypotensive effect of brimonidine was maintained during treatment periods of up to 1 year.[A178945] Brimonidine mediates vasoconstrictive effects and it was shown to exhibit anti-inflammatory properties in _ex vivo_ human skin model and _in vivo_ inflammation models.[A179041] In a clinial trials consisting of adults with moderate to severe facial erythema of rosacea, brimonidine was shown to improve the extent of redness at 3 hours after application, compared to placebo.[L6544] It was shown to be a potent vasoconstrictor of human subcutaneous vessels with a diameter of less than 200 µm. In _in vivo_ mouse inflammation models, brimonidine displayed anti-inflammatory properties by inhibiting edema.[A178978] In a randomized, double-blind study, brimonidine reduced erythema for the 12 hours of the study in a dose-dependent manner.[A178978] When adminsitered systemically, brimonidine was shown to cause cardiovascular effects by decreasing blood pressure, decreasing heart and respiratory rate, and prolonging the PR interval in the electrocardiogram. This is due to the targeting of adrenoceptors by the drug.[A178963,A178966] Although the clinical significance has not been established, there is evidence that brimonidine exhibits neuroprotective activity in experimental models of cerebral ischemia and optic nerve injury.[A178969] _In vitro_ studies show that brimonidine mediated protective effects on neuronal cells from kainate acid insult and on cultured retinal ganglion cells from glutamate-induced cytotoxicity, which is a possible mediator of secondary neuronal degeneration in human glaucoma. Neuroprotective actions of brimonidine were also demonstrated in rat models of acute retinal ischemia and chronic IOP elevation. It has been proposed that brimonidine may exert neuroprotective effects on the retina and optic nerve by enhancing intrinsic retinal ganglion cell survival mechanisms and/or induction of neuronal survival factors, such as bFGF.[A178951] However, further investigations are needed to conclude on these possible therapeutic benefits of the drug.	In the eye, alpha-1 adrenoceptors play a role in vasoconstriction, mydriasis, eyelid retraction, and elevation of intraocular pressure (IOP) whereas alpha-2 adrenoceptors are responsible for IOP reduction via a complex Gi-coupled signaling cascade pathway. Activation of alpha-2 receptors leads to inhibition of adenylyl cyclase and reduction of cyclic AMP levels. As a result, there is a decrease in norpinephrine (NE) release at the synaptic junction, NE-induced stimulation of beta-2 adrenoceptors, and production of aqueous humor by the ciliary epithelium.[A178969] An elevated IOP is the most significant risk factor for developing glaucomatous optic neuropathy, which is associated with progressive visual field loss and functional disability if left untreated.[A179002] Regardless of the etiology of the disease, the aim of current therapies for glaucoma is to reduce IOP, as reduction of IOP significantly reduces the risk of progression of vision loss even when IOP is already within the normal range.[A36674] When administered ophthalmically, brimonidine is rapidly absorbed into the eye, acts as an agonist at ocular alpha-2 adrenoceptors and lowers IOP via a dual mechanism of action.[A178981] It is proposed that initial dosing of the drug causes a reduction in aqueous humour production and chronic dosing leads to an increase in uveoscleral outflow.[A179002] Brimonidine does not affect episcleral venous pressure.[A178969] By reducing IOP, brimonidine aims to reduce the likelihood of glaucomatous visual field loss in ocular hypertension, and slow the progression of visual field defect in established open-angle glaucoma.[A178951] When applied topically on skin, brimonidine reduces erythema through direct vasocontriction of small arteries and veins.[A178978] As brimonidine mediates a potent peripheral vasoconstrictive activity by selectively working on the alpha-2 adrenoceptors, the use of brimonidine is thought to be efficacious for the treatment of facial erythema of rosacea, which is thought to arise from vasomotor instability and abnormal vasodilation of the superficial cutaneous vasculature of the face.[A178984]	Brimonidine readily penetrates the cornea following ocular administration [A178951] to reach pharmacologically active concentrations in the aqueous humor and ciliary body, the putative sites of its IOP-lowering activity.[A36674] Following ocular administration of 0.2% brimonidine solution, the peak plasma concentrations were achieved within 1 to 4 hours.[label] In a clinical study of adult subjects with facial erythema of rosacea, brimonidine was cutaneously applied on facial skin in a repeated manner. While there was no drug accumulation in plasma, the highest peak plasma concentrations (Cmax) and AUC were 46 ± 62 pg/mL and 417 ± 264 pgxhr/mL, respectively.[L6544]	Brimonidine is reported to be metabolized in the cornea. Brominidine that reaches the systemic circulation upon topical administration undergoes extensive hepatic metabolism mediated by hepatic aldehyde oxidases.[label]	LD<sub>50</sub> and Overdose Oral LD<sub>50</sub> is 50 mg/kg in mice and 100 mg/kg in rats.[MSDS] While there is limited clinial data on brimonidine overdose in adults, some common symptoms from oral overdoses of alpha-2 adrenergic agonists include hypotension, asthenia, vomiting, lethargy, sedation, bradycardia, arrhythmias, miosis, apnoea, hypotonia, hypothermia, respiratory depression and seizure. [L6544] Treatment of an oral overdose includes supportive and symptomatic therapy. Cases of brimonidine overdose have been reported in neonates, infants, and pediatric patients receiving brimonidine tartrate as part of medical treatment of congenital glaucoma or by accidental oral ingestion. In these cases, children experienced symptoms consistent with previously reported oral overdoses of alpha-2 adrenergic agonists in young children.[L6544] Nonclinical Toxicology At oral doses of up to 2.5 and 5 mg/kg/day in pregnant rats and rabbits, brimonidine was not shown to be teratogenic during gestation days 6 through 18. Findings from various _in vitro_ and _in vivo_ studies, including the Ames bacterial assay, CHO cell chromosomal aberration assay, and CD-1 mice studies, did not demonstrate any mutagenic or clastogenic potential of brimonidine.[label] There were no observable adverse effects on male or female fertility when tested at oral doses of up to 1 mg/kg, which is approximately 200 times the systemic exposure following the maximum recommended ophthalmic dose of 0.5% brimonidine.[label] Use in special populations Due to limited clinical data on the use of brimonidine pregnant or breastfeeding female patients, the use of brimonidine in these patients is generally not recommended and the use should be only considered after taking into account the benefit-to-risk ratio of continuing the drug therapy in these patients. In nursing mothers, the decision should be made whether to discontinue the drug or discontinue breastfeeding.[label] As the systemic absorption and elimination of brimonidine are not significantly affected by age, the use of brimonidine is considered safe in geriatric patients. In contrast, the use of brimonidine in infants under the age of 2 and pediatric patients under the age of 18 is strongly not recommended due to the reports of serious adverse events following ophthalmic administration of brimonidine in infants between the age of 28 days and 3 months.[L6544]	Following ocular administration of 0.2% brimonidine solution, the systemic half-life was approximately 3 hours.[label]	The protein binding of brimonidine has not been studied.	Brimonidine and its metabolites are predominantly eliminated via urinary excretion, with 74% of the total dose being found in the urine.[label]	The volume of distribution of brimonidine has not been established. In animal studies, brimonidine was shown to cross the placenta and enter into the fetal circulation to a limited extent.[label] As its lipophilicity is relatively low, brimonidine is not reported to easily cross the blood-brain barrier.[A178951]	The apparent clearance has not been studied. However, the systemic clearance of brimonidine is reported to be rapid.[A36674] Approximately 87% of the total radioactive dose of brimonidine was shown to be eliminated within 120 hours following oral administration.[label]	Organic compounds	Organoheterocyclic compounds	Diazanaphthalenes	Benzodiazines	[ "approved" ]	[ "D11AX", "D11A", "D11", "D", "S01GA", "S01G", "S01", "S", "S01EA", "S01E", "S01", "S" ]	[ "Humans and other mammals" ]	[ { "cost": "2.08", "description": "Apo-Brimonidine 0.2 % Solution", "unit": "ml" }, { "cost": "2.08", "description": "Pms-Brimonidine 0.2 % Solution", "unit": "ml" }, { "cost": "2.08", "description": "Ratio-Brimonidine 0.2 % Solution", "unit": "ml" }, { "cost": "2.08", "description": "Sandoz Brimonidine 0.2 % Solution", "unit": "ml" }, { "cost": "3.72", "description": "Alphagan 0.2 % Solution", "unit": "ml" }, { "cost": "6.53", "description": "Brimonidine 0.2% eye drop", "unit": "ml" }, { "cost": "13.85", "description": "Alphagan p 0.1% drops", "unit": "ml" }, { "cost": "14.65", "description": "Alphagan p 0.15% eye drops", "unit": "ml" }, { "cost": "29.82", "description": "Brimonidine tartrate 0.15% drp", "unit": "ml" }, { "cost": "33.96", "description": "Brimonidine Tartrate 0.2% Solution 5ml Bottle", "unit": "bottle" }, { "cost": "56.88", "description": "Brimonidine Tartrate 0.2% Solution 15ml Bottle", "unit": "bottle" }, { "cost": "67.85", "description": "Brimonidine Tartrate 0.2% Solution 10ml Bottle", "unit": "bottle" }, { "cost": "72.85", "description": "Brimonidine Tartrate 0.15% Solution 5ml Bottle", "unit": "bottle" }, { "cost": "79.52", "description": "Alphagan P 5ml Bottle .15% 5ml Bottle", "unit": "bottle" }, { "cost": "143.97", "description": "Alphagan P 0.1% Solution 10ml Bottle", "unit": "bottle" }, { "cost": "145.65", "description": "Brimonidine Tartrate 0.15% Solution 10ml Bottle", "unit": "bottle" }, { "cost": "152.32", "description": "Alphagan P 10ml Bottle .15% 10ml Bottle", "unit": "bottle" }, { "cost": "208.94", "description": "Alphagan P 0.1% Solution 15ml Bottle", "unit": "bottle" }, { "cost": "218.5", "description": "Brimonidine Tartrate 0.15% Solution 15ml Bottle", "unit": "bottle" }, { "cost": "228.5", "description": "Alphagan P 15ml Bottle .15% 15ml Bottle", "unit": "bottle" } ]	[ { "approved": "1995-06-13", "country": "United States", "expires": "2012-06-13", "number": "5424078" }, { "approved": "2006-05-02", "country": "Canada", "expires": "2014-09-19", "number": "2173974" }, { "approved": "2002-09-03", "country": "Canada", "expires": "2016-06-17", "number": "2225626" }, { "approved": "2016-03-29", "country": "United States", "expires": "2022-01-10", "number": "9295641" }, { "approved": "2003-09-30", "country": "United States", "expires": "2022-01-18", "number": "6627210" }, { "approved": "2004-01-06", "country": "United States", "expires": "2022-01-26", "number": "6673337" }, { "approved": "2003-05-13", "country": "United States", "expires": "2022-01-10", "number": "6562873" }, { "approved": "2003-11-04", "country": "United States", "expires": "2022-01-28", "number": "6641834" }, { "approved": "2006-04-18", "country": "United States", "expires": "2022-04-19", "number": "7030149" }, { "approved": "2008-01-22", "country": "United States", "expires": "2022-04-19", "number": "7320976" }, { "approved": "2010-01-05", "country": "United States", "expires": "2022-04-19", "number": "7642258" }, { "approved": "2012-03-13", "country": "United States", "expires": "2022-04-19", "number": "8133890" }, { "approved": "2013-01-15", "country": "United States", "expires": "2022-04-19", "number": "8354409" }, { "approved": "2014-06-10", "country": "United States", "expires": "2022-04-19", "number": "8748425" }, { "approved": "2008-01-29", "country": "United States", "expires": "2023-01-19", "number": "7323463" }, { "approved": "2007-09-04", "country": "United States", "expires": "2025-08-19", "number": "7265117" }, { "approved": "2014-10-14", "country": "United States", "expires": "2024-03-02", "number": "8858961" }, { "approved": "2001-11-13", "country": "United States", "expires": "2019-12-07", "number": "6316441" }, { "approved": "2015-06-02", "country": "United States", "expires": "2030-10-30", "number": "9044484" }, { "approved": "2013-04-02", "country": "United States", "expires": "2025-05-24", "number": "8410102" }, { "approved": "2011-11-08", "country": "United States", "expires": "2031-06-13", "number": "8053427" }, { "approved": "2008-10-21", "country": "United States", "expires": "2025-08-25", "number": "7439241" }, { "approved": "2013-08-20", "country": "United States", "expires": "2031-03-25", "number": "8513247" }, { "approved": "2013-04-23", "country": "United States", "expires": "2025-05-24", "number": "8426410" }, { "approved": "2013-08-20", "country": "United States", "expires": "2031-03-25", "number": "8513249" }, { "approved": "2014-10-14", "country": "United States", "expires": "2024-05-25", "number": "8859551" }, { "approved": "2012-07-31", "country": "United States", "expires": "2025-05-24", "number": "8231885" }, { "approved": "2012-04-24", "country": "United States", "expires": "2031-06-13", "number": "8163725" }, { "approved": "2016-10-25", "country": "United States", "expires": "2022-04-19", "number": "9474751" }, { "approved": "2017-06-27", "country": "United States", "expires": "2022-01-10", "number": "9687443" }, { "approved": "2016-08-23", "country": "United States", "expires": "2030-06-17", "number": "9421265" }, { "approved": "2017-09-26", "country": "United States", "expires": "2022-04-19", "number": "9770453" }, { "approved": "2018-01-09", "country": "United States", "expires": "2031-03-25", "number": "9861631" }, { "approved": "2012-10-23", "country": "United States", "expires": "2030-07-14", "number": "8293742" }, { "approved": "2018-01-09", "country": "United States", "expires": "2031-03-25", "number": "9861632" }, { "approved": "2018-03-06", "country": "United States", "expires": "2022-04-19", "number": "9907801" }, { "approved": "2018-03-06", "country": "United States", "expires": "2022-04-19", "number": "9907802" }, { "approved": "2019-02-12", "country": "United States", "expires": "2031-06-13", "number": "10201517" }, { "approved": "2019-06-04", "country": "United States", "expires": "2021-07-10", "number": "10307368" }, { "approved": "2016-02-16", "country": "United States", "expires": "2030-07-14", "number": "9259425" }, { "approved": "2009-07-27", "country": "United States", "expires": "2029-07-27", "number": "11596600" }, { "approved": "2009-07-27", "country": "United States", "expires": "2029-07-27", "number": "11833245" } ]	5-Bromo-6-(2-imidazolin-2-ylamino)quinoxaline \| Brimonidina \| Brimonidine \| Brimonidinum \| Bromoxidine \| ADRA2R \| ADRAR \| Alpha-2 adrenergic receptor subtype C10 \| Alpha-2A adrenoceptor \| Alpha-2A adrenoreceptor \| Alpha-2AAR \| ADRA2L1 \| ADRA2RL1 \| Alpha-2 adrenergic receptor subtype C2 \| Alpha-2B adrenoceptor \| Alpha-2B adrenoreceptor \| Alpha-2BAR \| ADRA2L2 \| ADRA2RL2 \| Alpha-2 adrenergic receptor subtype C4 \| Alpha-2C adrenoceptor \| Alpha-2C adrenoreceptor \| Alpha-2CAR \| 1.2.3.1 \| Aldehyde oxidase 1 \| AO \| Azaheterocycle hydroxylase	[ "Alphagan", "Alphagan P", "Alphagan P", "Alphagan P", "Alphagan P", "Alphagan P", "Apo-brimonidine", "Apo-brimonidine-timop", "Brim-Dor PF", "Brimonidine", "Brimonidine", "Brimonidine", "Brimonidine", "Brimonidine", "Brimonidine", "Brimonidine", "Brimonidine Ophthalmic", "Brimonidine P", "Brimonidine Tartrate", "Brimonidine Tartrate", "Brimonidine Tartrate", "Brimonidine Tartrate", "Brimonidine Tartrate", "Brimonidine Tartrate", "Brimonidine Tartrate", "Brimonidine Tartrate", "Brimonidine Tartrate", "Brimonidine Tartrate", "Brimonidine Tartrate", "Brimonidine Tartrate", "Brimonidine Tartrate", "Brimonidine Tartrate", "Brimonidine Tartrate", "Brimonidine Tartrate", "Brimonidine Tartrate", "Brimonidine Tartrate", "Brimonidine Tartrate", "Brimonidine tartrate", "Brimonidine Tartrate", "Brimonidine Tartrate", "Brimonidine Tartrate", "Brimonidine Tartrate", "Brimonidine Tartrate", "Brimonidine tartrate", "Brimonidine Tartrate", "Brimonidine tartrate", "Brimonidine Tartrate", "Brimonidine Tartrate", "Brimonidine Tartrate", "Brimonidine Tartrate", "Brimonidine Tartrate 0.25% / Ivermectin 1% / Metronidazole 1% / Niacinamide 4%", "Brimonidine Tartrate 0.25% / Potassium Azeloyl Diglycinate 8%", "Brimonidine Tartrate and Timolol Maleate", "BRIMONIDINE TARTRATE and TIMOLOL MALEATE", "Brimonidine Tartrate and Timolol Maleate", "Brimonidine Tartrate and Timolol Maleate", "Brimonidine Tartrate and Timolol Maleate", "Brimonidine tartrate and Timolol maleate", "Brimonidine Tartrate and Timolol Maleate", "Brimonidine Tartrate and Timolol Maleate", "Brimonidine Tartrate and Timolol Maleate", "Brimonidine Tartrate Ophthalmic Solution", "Brimonidine Tartrate Ophthalmic Solution 0.2%", "Brimonidine Tartrate ophthalmic solution, 0.15%", "Brimonidine Tartrate ophthalmic solution, 0.15%", "Brimonidine Tartrate Ophthalmic Solution, 0.2%", "Brimonidine Tartrate/Timolol Maleate", "Brimonidine Tartrate/Timolol Maleate", "Brimonidine Tartrate/Timolol Maleate", "Brimonidine Tartrate/Timolol Maleate", "Brimonidine Tartrate/Timolol Maleate Ophthalmic Solution", "Brimonidine Tartrate/Timolol Maleate Ophthalmic Solution", "Combigan", "Combigan", "Combigan", "Dom-brimonidine", "Jamp Brimonidine/timolol", "Jamp-brimonidine", "Lumify", "LUMIFY Redness Reliever Eye Drops", "Med-brimonidine", "Mirvaso", "Mirvaso", "Mirvaso", "Mirvaso", "Mirvaso", "Mirvaso", "Mirvaso", "Mirvaso", "Mirvaso", "Mirvaso", "Mirvaso", "Onreltea", "PMS-brimonidine", "Ratio-brimonidine", "Riva-brimonidine", "Sandoz Brimonidine", "Sandoz Brimonidine / Timolol", "Simbrinza", "Simbrinza", "Simbrinza", "Simbrinza", "Simbrinza", "Tim-Brim-Dor PF", "Tim-Brim-Dor-Lat" ]	[]	[ "Combigan", "Tim-Brim-Dor-Lat", "Tim-Brim-Dor PF", "Brim-Dor PF", "Brimonidine Tartrate 0.25% / Ivermectin 1% / Metronidazole 1% / Niacinamide 4%", "Simbrinza", "Combigan", "Simbrinza", "Simbrinza", "Combigan", "Brimonidine Tartrate/Timolol Maleate", "Brimonidine Tartrate and Timolol Maleate", "Brimonidine Tartrate/Timolol Maleate Ophthalmic Solution", "Brimonidine Tartrate/Timolol Maleate", "BRIMONIDINE TARTRATE and TIMOLOL MALEATE", "Apo-brimonidine-timop", "Brimonidine Tartrate and Timolol Maleate", "Jamp Brimonidine/timolol", "Brimonidine Tartrate and Timolol Maleate", "Brimonidine Tartrate and Timolol Maleate", "Brimonidine Tartrate/Timolol Maleate Ophthalmic Solution", "Sandoz Brimonidine / Timolol", "Brimonidine Tartrate/Timolol Maleate", "Brimonidine tartrate and Timolol maleate", "Brimonidine Tartrate/Timolol Maleate", "Brimonidine Tartrate and Timolol Maleate", "Brimonidine Tartrate and Timolol Maleate", "Brimonidine Tartrate and Timolol Maleate", "Simbrinza", "Simbrinza" ]	[ "P08913", "P18089", "P18825" ]	[ "Q06278" ]	[]	[]
DB00485	Dicloxacillin	One of the penicillins which is resistant to penicillinase.	solid	Used to treat infections caused by penicillinase-producing staphylococci which have demonstrated susceptibility to the drug.	Dicloxacillin is a beta-lactamase resistant penicillin similar to oxacillin. Dicloxacillin has <i>in vitro</i> activity against gram-positive and gram-negative aerobic and anaerobic bacteria. The bactericidal activity of dicloxacillin results from the inhibition of cell wall synthesis and is mediated through dicloxacillin binding to penicillin binding proteins (PBPs). Dicloxacillin is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, and cephalosporinases and extended spectrum beta-lactamases.	Dicloxacillin exerts a bactericidal action against penicillin-susceptible microorganisms during the state of active multiplication. All penicillins inhibit the biosynthesis of the bacterial cell wall. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, dicloxacillin inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that dicloxacillin interferes with an autolysin inhibitor.	Absorption of the isoxazolyl penicillins after oral administration is rapid but incomplete: peak blood levels are achieved in 1-1.5 hours. Oral absorption of cloxacillin, dicloxacillin, oxacillin and nafcillin is delayed when the drugs are administered after meals.	null	Oral LD<sub>50</sub> in rat is 3579 mg/kg. Symptoms of overexposure include irritation, rash, labored breathing, hives, itching, wheezing, nausea, chills, and fever.	The elimination half-life for dicloxacillin is about 0.7 hour.	Binds to serum protein, mainly albumin.	Dicloxacillin sodium is rapidly excreted as unchanged drug in the urine by glomerular filtration and active tubular secretion.	null	null	Organic compounds	Organic acids and derivatives	Carboxylic acids and derivatives	Amino acids, peptides, and analogues	[ "approved", "investigational", "vet_approved" ]	[ "J01CR", "J01C", "J01", "J", "J01CF", "J01C", "J01", "J" ]	[ "Enteric bacteria and other eubacteria" ]	[ { "cost": "1.2", "description": "Dicloxacillin 500 mg capsule", "unit": "capsule" }, { "cost": "1.25", "description": "Dicloxacillin Sodium 500 mg capsule", "unit": "capsule" }, { "cost": "0.66", "description": "Dicloxacillin 250 mg capsule", "unit": "capsule" }, { "cost": "0.69", "description": "Dicloxacillin Sodium 250 mg capsule", "unit": "capsule" } ]	[]	(2S,5R,6R)-6-({[3-(2,6-dichlorophenyl)-5-methyl-1,2-oxazol-4-yl]carbonyl}amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid \| Dicloxacilina \| Dicloxacillin \| Dicloxacillina \| Dicloxacilline \| Dicloxacillinum \| Putative D-alanyl-D-alanine carboxypeptidase \| exp2 \| Exported protein 2 \| PBP-1A \| pbp2b \| 1,4-cineole 2-exo-monooxygenase \| 1,8-cineole 2-exo-monooxygenase \| 1.14.14.1 \| Albendazole monooxygenase (sulfoxide-forming) \| Albendazole sulfoxidase \| Cholesterol 25-hydroxylase \| CYP3A3 \| CYPIIIA3 \| CYPIIIA4 \| Cytochrome P450 3A3 \| Cytochrome P450 HLp \| Cytochrome P450 NF-25 \| Cytochrome P450-PCN1 \| Nifedipine oxidase \| Quinine 3-monooxygenase \| Intestinal H(+)/peptide cotransporter \| Oligopeptide transporter, small intestine isoform \| PEPT1 \| Peptide transporter 1 \| Kidney H(+)/peptide cotransporter \| Oligopeptide transporter, kidney isoform \| PEPT2 \| Peptide transporter 2	[ "Dicloxacillin Sodium", "Dicloxacillin Sodium", "Dicloxacillin Sodium", "Dicloxacillin Sodium", "Dicloxacillin Sodium", "Dicloxacillin Sodium", "Dicloxacillin Sodium", "Dicloxacillin Sodium", "Dicloxacillin Sodium", "Dicloxacillin Sodium", "Dicloxacillin Sodium", "Dicloxacillin Sodium", "Dicloxacillin Sodium", "Dicloxacillin Sodium", "Dicloxacillin Sodium", "Dicloxacillin Sodium", "Dicloxacillin Sodium", "Dicloxacillin Sodium", "Dicloxacillin Sodium", "Dicloxacillin Sodium", "Dicloxacillin Sodium", "Dicloxacillin Sodium", "Dicloxacillin Sodium", "Dicloxacillin Sodium", "Dicloxacillin Sodium", "Dicloxacillin Sodium", "Dicloxacillin Sodium", "Dicloxacillin Sodium", "Dicloxacillin Sodium", "Dicloxacillin Sodium", "Dicloxacillin Sodium", "Dicloxacillin Sodium", "Dicloxacillin Sodium", "Dicloxacillin Sodium", "Dicloxacillin Sodium", "Dicloxacillin Sodium", "Dicloxacillin Sodium", "Dicloxacillin Sodium", "Dicloxacillin Sodium", "Truemed Group LLC" ]	[ "Amcidil", "Betaclox", "Cloxagen", "Dacocilin", "Damacir", "Dicillin", "Diclex", "Diclocil", "Dicloplus", "Dicloson", "Dicloxal", "Dicloxgen", "Dicloxina", "Dyclobiot", "Dynapen", "Posipen", "Quimocyclar", "Staklox", "Terbocloxil", "Ziefmycin" ]	[]	[]	[ "P08684" ]	[ "P02768" ]	[ "P46059", "Q16348" ]
DB00486	Nabilone	Nabilone (marketed as Cesamet) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). Although structurally distinct from THC, nabilone mimics THC's structure and pharmacological activity through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, however it is considered to be twice as active as Δ⁹-THC. Nabilone is approved by the FDA for the treatment of nausea and vomiting associated with cancer chemotherapy in patients who have failed to respond adequately to conventional antiemetic treatments [FDA Label]. Tetrahydrocannabinol (THC) and cannabidiol (CBD) are the two most abundant cannabinoids found naturally in the resin of the marijuana plant, both of which are pharmacologically active due to their interaction with cannabinoid receptors that are found throughout the body [A32830]. While both CBD and THC are used for medicinal purposes, they have different receptor activity, function, and physiological effects. If not provided in their activated form (such as through synthetic forms like Nabilone or [DB00470]), THC and CBD are obtained through conversion from their precursors, tetrahydrocannabinolic acid-A (THCA-A) and cannabidiolic acid (CBDA), through decarboxylation reactions. This can be achieved through heating, smoking, vaporization, or baking of dried unfertilized female cannabis flowers. From a pharmacological perspective, Cannabis' diverse receptor profile explains its potential application for such a wide variety of medical conditions. Cannabis contains more than 400 different chemical compounds, of which 61 are considered cannabinoids, a class of compounds that act upon endogenous cannabinoid receptors of the body [A32584]. The endocannabinoid system is widely distributed throughout the central and peripheral nervous system (via the Cannabinoid Receptors CB1 and CB2) and plays a role in many physiological processes such as inflammation, cardiovascular function, learning, pain, memory, stress and emotional regulation, and the sleep/wake cycle among many others [A32824]. CB1 receptors are found in both the central and peripheral nervous system, and are most abundant in the hippocampus and amygdala, which are the areas of the brain responsible for short-term memory storage and emotional regulation. CB2 receptors are mainly located in the peripheral nervous system and can be found on lymphoid tissue where they are involved in regulation of immune function [A32676]. In Canada, the United States, the United Kingdom and Mexico, nabilone is marketed as Cesamet. It was approved in 1985 by the United States FDA for treatment of chemotherapy-induced nausea and vomiting that has not responded to conventional antiemetics. Though it was approved by the FDA in 1985, the drug only began marketing in the United States in 2006. It is also approved for use in treatment of anorexia and weight loss in patients with AIDS. Nabilone is a racemate consisting of the (S,S) and the (R,R) isomers.	solid	Nabilone is indicated for the treatment of the nausea and vomiting associated with cancer chemotherapy in patients who have failed to respond adequately to conventional antiemetic treatments. This restriction is required because a substantial proportion of any group of patients treated with Nabilone can be expected to experience disturbing psychotomimetic reactions not observed with other antiemetic agents.	Nabilone is a cannabinoid with therapeutic uses. It is an analog of dronabinol (also known as tetrahydrocannabinol or THC), the psychoactive ingredient in cannabis. Although structurally distinct from THC, nabilone mimics THC's structure and pharmacological activity through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, however it is considered to be twice as active as Δ⁹-THC.	Nabilone is an orally active synthetic cannabinoid which, like other cannabinoids, has complex effects on the central nervous system (CNS). It has been suggested that the antiemetic effect of nabilone is caused by interaction with the cannabinoid receptor system, i.e., the CB (1) receptor, which is a component of the endocannabinoid system of the body. The endocannabinoid system is widely distributed throughout the central and peripheral nervous system (via the Cannabinoid Receptors CB1 and CB2) and plays a role in many physiological processes such as inflammation, cardiovascular function, learning, pain, memory, stress and emotional regulation, and the sleep/wake cycle among many others [A32824]. CB1 receptors are found in both the central and peripheral nervous system, and are most abundant in the hippocampus and amygdala, which are the areas of the brain responsible for short-term memory storage and emotional regulation. CB2 receptors are mainly located in the peripheral nervous system and can be found on lymphoid tissue where they are involved in regulation of immune function [A32676].	Nabilone appears to be completely absorbed from the human gastrointestinal tract when administered orally. Following oral administration of a 2 mg dose of radiolabeled nabilone, peak plasma concentrations of approximately 2 ng/mL nabilone and 10 ng equivalents/mL total radioactivity are achieved within 2.0 hours.	Hepatic. Two metabolic pathways have been suggested. The major pathway probably involves the direct oxidation of Nabilone to produce hydroxylic and carboxylic analogues. These compounds are thought to account for the remaining plasma radioactivity when carbinol metabolites have been extracted.	Symptoms of overdose include difficulty in breathing, hallucinations, mental changes (severe), nervousness or anxiety (severe). Monkeys treated with Nabilone at doses as high as 2mg/kg/day for a year experienced no significant adverse events. This result contrasts with the finding in a planned 1-year dog study that was prematurely terminated because of deaths associated with convulsions in dogs receiving as little as 0.5mg/kg/day. The earliest deaths, however, occurred at 56 days in dogs receiving 2mg/kg/day. The unusual vulnerability of the dog is not understood; it is hypothesised, however, that the explanation lies in the fact that the dog differs markedly from other species (including humans) in its metabolism of Nabilone.	The plasma half-life (T1/2) values for nabilone and total radioactivity of identified and unidentified metabolites are about 2 and 35 hours, respectively.	null	The route and rate of the elimination of nabilone and its metabolites are similar to those observed with other cannabinoids, including delta-9-THC (dronabinol). When nabilone is administered intravenously, the drug and its metabolites are eliminated mainly in the feces (approximately 67%) and to a lesser extent in the urine (approximately 22%) within 7 days. Of the 67% recovered from the feces, 5% corresponded to the parent compound and 16% to its carbinol metabolite. Following oral administration about 60% of nabilone and its metabolites were recovered in the feces and about 24% in urine. Therefore, it appears that the major excretory pathway is the biliary system.	The apparent volume of distribution of nabilone is about 12.5 L/kg.	null	Organic compounds	Organoheterocyclic compounds	Naphthopyrans	Naphthopyranones	[ "approved", "investigational" ]	[ "A04AD", "A04A", "A04", "A" ]	[ "Humans and other mammals" ]	[ { "cost": "3.49", "description": "Cesamet 0.5 mg Capsule", "unit": "capsule" }, { "cost": "13.99", "description": "Cesamet 1 mg capsule", "unit": "capsule" } ]	[]	Nabilon \| Nabilona \| Nabilone \| Nabilonum \| CB-2 \| CB2 \| CB2A \| CB2B \| CX5 \| hCB2 \| CANN6 \| CB-R \| CB1 \| CNR \| (R)-limonene 6-monooxygenase \| (S)-limonene 6-monooxygenase \| (S)-limonene 7-monooxygenase \| 1.14.14.1 \| Cholesterol 25-hydroxylase \| CYP2C10 \| CYPIIC9 \| Cytochrome P-450MP \| Cytochrome P450 MP-4 \| Cytochrome P450 MP-8 \| Cytochrome P450 PB-1 \| S-mephenytoin 4-hydroxylase \| 1,4-cineole 2-exo-monooxygenase \| 1,8-cineole 2-exo-monooxygenase \| 1.14.14.1 \| Albendazole monooxygenase (sulfoxide-forming) \| Albendazole sulfoxidase \| Cholesterol 25-hydroxylase \| CYP3A3 \| CYPIIIA3 \| CYPIIIA4 \| Cytochrome P450 3A3 \| Cytochrome P450 HLp \| Cytochrome P450 NF-25 \| Cytochrome P450-PCN1 \| Nifedipine oxidase \| Quinine 3-monooxygenase \| 1.14.14.1 \| CYPIIC8 \| Cytochrome P450 form 1 \| Cytochrome P450 IIC2 \| Cytochrome P450 MP-12 \| Cytochrome P450 MP-20 \| S-mephenytoin 4-hydroxylase \| 1.14.14.1 \| 4-nitrophenol 2-hydroxylase \| CYP2E \| CYPIIE1 \| Cytochrome P450-J \| 1.14.14.- \| Albendazole monooxygenase (hydroxylating) \| Albendazole monooxygenase (sulfoxide-forming) \| Arachidonic acid epoxygenase \| CYPIIJ2 \| Hydroperoxy icosatetraenoate isomerase	[ "Act Nabilone", "Act Nabilone", "Apo-nabilone", "Apo-nabilone", "Apo-nabilone", "Cesamet", "Cesamet", "Cesamet", "Cesamet", "Cesamet", "Cesamet", "Cesamet", "PMS-nabilone", "PMS-nabilone", "PMS-nabilone", "Ran-nabilone", "Ran-nabilone", "Ran-nabilone", "Teva-nabilone", "Teva-nabilone", "Teva-nabilone" ]	[ "Nabilone" ]	[]	[ "P34972", "P21554" ]	[ "P11712", "P08684", "P10632", "P05181", "P51589" ]	[]	[]
DB00487	Pefloxacin	A synthetic broad-spectrum fluoroquinolone antibacterial agent active against most gram-negative and gram-positive bacteria.	solid	For the treatment of uncomplicated gonococcal urethritis in males and for gram-negative-bacterial infections in the gastrointestinal system and the genitourinary tract.	Pefloxacin is a fluoroquinolone antibiotic. Flouroquinolones such as pefloxacin possess excellent activity against gram-negative aerobic bacteria such as <i>E.coli</i> and <i>Neisseria gonorrhoea</i> as well as gram-positive bacteria including <i>S. pneumoniae</i> and <i>Staphylococcus aureus</i>. They also posses effective activity against shigella, salmonella, campylobacter, gonococcal organisms, and multi drug resistant pseudomonas and enterobacter.	The bactericidal action of pefloxacin results from interference with the activity of the bacterial enzymes DNA gyrase and topoisomerase IV, which are needed for the transcription and replication of bacterial DNA. DNA gyrase appears to be the primary quinolone target for gram-negative bacteria. Topoisomerase IV appears to be the preferential target in gram-positive organisms. Interference with these two topoisomerases results in strand breakage of the bacterial chromosome, supercoiling, and resealing. As a result DNA replication and transcription is inhibited.	Well absorbed by the oral route.	Hepatic. Primary metabolites are pefloxacin N-oxide and norfloxacin.	Adverse reactions include peripheral neuropathy, nervousness, agitation, anxiety, and phototoxic events (rash, itching, burning) due to sunlight exposure.	8.6 hours	20-30%	null	null	null	Organic compounds	Organoheterocyclic compounds	Quinolines and derivatives	Quinoline carboxylic acids	[ "approved" ]	[ "J01MA", "J01M", "J01", "J" ]	[ "Enteric bacteria and other eubacteria" ]	[]	[]	Pefloxacin \| Pefloxacine \| Pefloxacino \| Pefloxacinum \| PFLX \| 5.6.2.2 \| DNA topoisomerase II, beta isozyme \| 5.99.1.3 \| Topoisomerase IV subunit A \| 5.99.1.3 \| 5.6.2.2 \| DNA topoisomerase II, alpha isozyme \| TOP2 \| 5.99.1.2 \| DNA topoisomerase I \| Omega-protein \| Relaxing enzyme \| Swivelase \| Untwisting enzyme \| 1.14.14.1 \| Cholesterol 25-hydroxylase \| CYPIA2 \| Cytochrome P(3)450 \| Cytochrome P450 4 \| Cytochrome P450-P3 \| Hydroperoxy icosatetraenoate dehydratase	[]	[ "Labocton" ]	[]	[ "Q02880", "P11388" ]	[ "P05177" ]	[]	[]
DB00488	Altretamine	An alkylating agent proposed as an antineoplastic. It also acts as a chemosterilant for male houseflies and other insects.	solid	For use as a single agent in the palliative treatment of patients with persistent or recurrent ovarian cancer following first-line therapy with a cisplatin and/or alkylating agent-based combination.	Altretamine is a novel antineoplastic agent. The precise mechanism by which altretamine exerts its cytotoxic effect is unknown, although a number of theoretical possibilities have been studied. Structurally, altretamine resembles the alkylating agent triethylenemelamine, yet <i>in vitro</i> tests for alkylating activity of altretamine and its metabolitics have been negative. Altretamine has been demonstrated to be efficacious for certain ovarian tumors resistant to classical alkylating agents. Metabolism of altretamine is a requirement of cytotoxicity. Synthetic monohydroxymethylmelamines, and products of altretamine metabolism, <i>in vitro</i> and <i>in vivo</i>, can form covalent adducts with tissue macromolecules including DNA, but the relevance of these reactions to antitumor activity is unknown.	The precise mechanism by which altretamine exerts its cytotoxic effect is unknown although it is classified as an alkylating anti-neoplastic agent. Through this mechanism, the drug is metabolized into alkylating agents by N-demethylation. These alkylating species consequently damage tumor cells.	null	null	null	4.7-10.2 hours	94%	Human urinary metabolites were Ndemethylated homologues of altretamine with <1% unmetabolized altretamine excreted at 24 hours.	null	null	Organic compounds	Organic nitrogen compounds	Organonitrogen compounds	Amines	[ "approved" ]	[ "L01XX", "L01X", "L01", "L" ]	[ "Humans and other mammals" ]	[ { "cost": "12.03", "description": "Hexalen 50 mg capsule", "unit": "capsule" } ]	[]	2,4,6-tris(dimethylamino)-1,3,5-triazine \| 2,4,6-tris(dimethylamino)-s-triazine \| Altretamin \| Altretamina \| Altretamine \| Altrétamine \| Altretaminum \| Hexamethylmelamine \| HMM	[ "Hexalen", "Hexalen", "Hexalen" ]	[ "Hexastat" ]	[]	[]	[]	[]	[]
DB00489	Sotalol	Sotalol is a methanesulfonanilide developed in 1960.[A178579] It was the first of the class III anti arrhythmic drugs.[A178579] Sotalol was first approved as an oral tablet on 30 October 1992.[L6334] A racemic mixture of sotalol is currently formulated as a tablet, oral solution, and intravenous injection indicated for life threatening ventricular arrhythmias and maintaining normal sinus rhythm in atrial fibrillation or flutter.[Label,L6373,L6376]	solid	Sotalol is indicated to treat life threatening ventricular arrhytmias and maintain normal sinus rhythm in patients with atrial fibrillation or flutter.[Label] There are also oral solutions and intravenous injections indicated for patients requiring sotalol, but for whom a tablet would not be appropriate.[Label,L6373,L6376]	Sotalol is a competitive inhibitor of the rapid potassium channel.[A178522] This inhibition lengthens the duration of action potentials and the refractory period in the atria and ventricles.[A178540,A178561] The inhibition of rapid potassium channels is increases as heart rate decreases, which is why adverse effects like torsades de points is more likely to be seen at lower heart rates.[A178579] L-sotalol also has beta adrenergic receptor blocking activity seen above plasma concentrations of 800ng/L.[A178579] The beta blocking ability of sotalol further prolongs action potentials.[A178579] D-sotalol does not have beta blocking activity but also reduces a patient's heart rate while standing or exercising.[A178579] These actions combine to produce a negative inotropic effect that reduces the strength of contractility of muscle cells in the heart.[A178522] Extension of the QT interval is also adversely associated with the induction of arrhythmia in patients.[A178561] Hyperglycemia is a greater risk for non insulin dependant diabetics than insulin dependant diabetics.[A33725] Beta blockers inhibit insulin secretion which may cause hyperglycemia in type II diabetes mellitus.[A33725] The risk of hypoglycemia is higher in insulin dependant diabetes than non insulin dependant diabetics.[A33725] Beta blockers decrease secretion of insulin, which may mask hypoglycemia in an insulin dependant patient.[A33725] Beta blockers also increase glucose uptake into cells which may prolong or potentiate hypoglycemia.[A33725] Further information regarding adverse reactions can be found here.[L6379]	Sotalol inhibits beta-1 adrenoceptors in the myocardium as well as rapid potassium channels to slow repolarization, lengthen the QT interval, and slow and shorten conduction of action potentials through the atria.[A178522,A178540,A178561,A34177] The action of sotalol on beta adrenergic receptors lengthens the sinus node cycle, conduction time through the atrioventricular node, refractory period, and duration of action potentials.[A178579]	Sotalol is 90-100% bioavailable.[Label,A178483] When taken with a meal, adsorption is lowered by 18%.[Label,A178483] In patients with a creatinine clearance >80mL/min, the maximum concentration is 6.25±2.19.[A178483]	Sotalol is not metabolized.[Label,A178483]	Patients experiencing an overdose may present with bradycardia, congestive heart failure, hypotension, bronchospasm, and hypoglycemia.[Label] Larger intentional overdoses may present as hypotension, bradycardia, cardiac asystole, prolonged QT interval, torsade de pointes, ventricular tachycardia, and premature ventricular complexes.[Label] Stop administering sotalol and observe the patient until the QT interval returns to normal and the heart rate rises above 50 beats per minute.[Label] Hemodialysis may help lower plasma concentrations of sotalol as it is not bound to plasma proteins.[Label] Bradycardia and cardiac asystole may be treated with [atropine], other anticholinergic drugs, beta adrenergic agonists, or transvenous cardiac pacing.[Label]. Second or third degree heart block may be treated with a transvenous cardiac pacemaker.[Label] Hypotension may be treated with [epinephrine] or [norepinephrine].[Label] Bronchospasm may be treated with [aminophylline] or a beta-2 agonist, possibly at higher than normal doses.[Label] Torsade de pointes may be treated with DC cardioversion, transvenous cardiac pacing, epinephrine, or [magnesium sulfate].[Label] The oral LD50 for rats is 3450mg/kg, intraperitoneal LD50 for rats is 680mg/kg, oral LD50 for mice is 2600mg/kg, and intraperitoneal LD50 for mice is 670mg/kg.[MSDS] Pregnant rabbits given 6 times the maximum recommended human dose showed an increase in fetal death and maternal toxicity, while rats given 18 times the maximum recommended human dose had an increased number of fetal resorptions.[Label] Sotalol is present in human breast milk so patients taking sotalol should not breast feed.[Label] Sotalol has not been found to be carcinogenic.[Label] No studies have been performed regarding mutagenicity or clastogenicity.[Label] In animal studies, sotalol was not associated with a reduction in fertility aside from smaller litter sizes.[Label] Further information regarding adverse reactions can be found here.[L6379]	The terminal elimination half life is 10-20 hours in healthy patients.[Label,A178483] In patients with a creatinine clearance >80mL/min, the half life is 17.5±0.97h.[A178483] In patients with a creatinine clearance 30-80mL/min, the half life is 22.7±6.4h.[A178483] In patients with a creatinine clearance 10-30mL/min, the half life is 64±27.2h.[A178483] In patients with a creatinine clearance <10mL/min, the half life is 97.9±57.3h.[A178483]	0%.[Label,A178483]	80-90% of a given dose is excreted in the urine as unchanged sotalol.[Label,A178483] A small fraction of the doses is excreted in the feces as unchanged sotalol.[Label,A178483]	The apparent volume of distribution is 1.2-2.4L/kg.[Label,A178483]	In patients with a creatinine clearance >80mL/min, the plasma clearance is 6.78±2.72L/h and the renal clearance is 4.99±1.43L/h.[A178483] In patients with a creatinine clearance 30-80mL/min, the plasma clearance is 2.74±0.53L/h and the renal clearance is 2.00±0.67L/h.[A178483] In patients with a creatinine clearance 10-30mL/min, the plasma clearance is 1.56±0.44L/h and the renal clearance is 0.65±0.31L/h.[A178483] In patients with a creatinine clearance <10mL/min, the plasma clearance is 0.65±0.20L/h and the renal clearance is 0.27±0.13L/h.[A178483]	Organic compounds	Benzenoids	Benzene and substituted derivatives	Sulfanilides	[ "approved" ]	[ "C07AA", "C07A", "C07", "C", "C07BA", "C07B", "C07", "C", "C07FX", "C07F", "C07", "C" ]	[ "Humans and other mammals" ]	[ { "cost": "2.35", "description": "Sotalol 80 mg tablet", "unit": "tablet" }, { "cost": "2.56", "description": "Sotalol af 80 mg tablet", "unit": "tablet" }, { "cost": "2.61", "description": "Sorine 80 mg tablet", "unit": "tablet" }, { "cost": "2.67", "description": "Sotalol HCl (AF) 80 mg tablet", "unit": "tablet" }, { "cost": "2.67", "description": "Sotalol HCl 80 mg tablet", "unit": "tablet" }, { "cost": "3.13", "description": "Sotalol 120 mg tablet", "unit": "tablet" }, { "cost": "3.26", "description": "Sotalol HCl 120 mg tablet", "unit": "tablet" }, { "cost": "3.42", "description": "Sotalol af 120 mg tablet", "unit": "tablet" }, { "cost": "3.46", "description": "Sorine 120 mg tablet", "unit": "tablet" }, { "cost": "3.56", "description": "Sotalol HCl (AF) 120 mg tablet", "unit": "tablet" }, { "cost": "3.74", "description": "Betapace af 80 mg tablet", "unit": "tablet" }, { "cost": "3.92", "description": "Sotalol 160 mg tablet", "unit": "tablet" }, { "cost": "4.07", "description": "Sotalol HCl 160 mg tablet", "unit": "tablet" }, { "cost": "4.12", "description": "Betapace 80 mg tablet", "unit": "tablet" }, { "cost": "4.27", "description": "Sotalol af 160 mg tablet", "unit": "tablet" }, { "cost": "4.31", "description": "Sorine 160 mg tablet", "unit": "tablet" }, { "cost": "4.45", "description": "Sotalol HCl (AF) 160 mg tablet", "unit": "tablet" }, { "cost": "4.99", "description": "Betapace af 120 mg tablet", "unit": "tablet" }, { "cost": "5.09", "description": "Sotalol 240 mg tablet", "unit": "tablet" }, { "cost": "5.29", "description": "Sotalol HCl 240 mg tablet", "unit": "tablet" }, { "cost": "5.5", "description": "Betapace 120 mg tablet", "unit": "tablet" }, { "cost": "5.6", "description": "Sorine 240 mg tablet", "unit": "tablet" }, { "cost": "6.24", "description": "Betapace af 160 mg tablet", "unit": "tablet" }, { "cost": "6.87", "description": "Betapace 160 mg tablet", "unit": "tablet" }, { "cost": "7.8", "description": "Sotalol hcl 150 mg/10 ml vial", "unit": "ml" }, { "cost": "8.94", "description": "Betapace 240 mg tablet", "unit": "tablet" }, { "cost": "311.06", "description": "Betapace AF 60 120 mg tablet Bottle", "unit": "bottle" }, { "cost": "538.2", "description": "Betapace AF 100 160 mg tablet Box", "unit": "box" }, { "cost": "0.62", "description": "Apo-Sotalol 80 mg Tablet", "unit": "tablet" }, { "cost": "0.62", "description": "Co Sotalol 80 mg Tablet", "unit": "tablet" }, { "cost": "0.62", "description": "Mylan-Sotalol 80 mg Tablet", "unit": "tablet" }, { "cost": "0.62", "description": "Novo-Sotalol 80 mg Tablet", "unit": "tablet" }, { "cost": "0.62", "description": "Nu-Sotalol 80 mg Tablet", "unit": "tablet" }, { "cost": "0.62", "description": "Pms-Sotalol 80 mg Tablet", "unit": "tablet" }, { "cost": "0.62", "description": "Ratio-Sotalol 80 mg Tablet", "unit": "tablet" }, { "cost": "0.62", "description": "Sandoz Sotalol 80 mg Tablet", "unit": "tablet" }, { "cost": "0.68", "description": "Apo-Sotalol 160 mg Tablet", "unit": "tablet" }, { "cost": "0.68", "description": "Co Sotalol 160 mg Tablet", "unit": "tablet" }, { "cost": "0.68", "description": "Mylan-Sotalol 160 mg Tablet", "unit": "tablet" }, { "cost": "0.68", "description": "Novo-Sotalol 160 mg Tablet", "unit": "tablet" }, { "cost": "0.68", "description": "Nu-Sotalol 160 mg Tablet", "unit": "tablet" }, { "cost": "0.68", "description": "Pms-Sotalol 160 mg Tablet", "unit": "tablet" }, { "cost": "0.68", "description": "Ratio-Sotalol 160 mg Tablet", "unit": "tablet" }, { "cost": "0.68", "description": "Sandoz Sotalol 160 mg Tablet", "unit": "tablet" } ]	[ { "approved": "2017-08-08", "country": "United States", "expires": "2035-08-31", "number": "9724297" }, { "approved": "2019-02-19", "country": "United States", "expires": "2034-04-01", "number": "10206895" }, { "approved": "2019-12-24", "country": "United States", "expires": "2038-08-18", "number": "10512620" }, { "approved": "2021-05-25", "country": "United States", "expires": "2034-04-01", "number": "11013703" }, { "approved": "2020-10-13", "country": "United States", "expires": "2039-04-05", "number": "10799138" }, { "approved": "2019-08-21", "country": "United States", "expires": "2039-08-21", "number": "11583216" }, { "approved": "2018-08-14", "country": "United States", "expires": "2038-08-14", "number": "11696902" }, { "approved": "2014-11-19", "country": "United States", "expires": "2034-11-19", "number": "11850222" } ]	4'-(1-hydroxy-2-(isopropylamino)ethyl)methane sulfonanilide \| Sotalol \| Sotalolo \| Sotalolum \| β-cardone \| ADRB1R \| B1AR \| Beta-1 adrenoceptor \| Beta-1 adrenoreceptor \| ADRB2R \| B2AR \| Beta-2 adrenoceptor \| Beta-2 adrenoreceptor \| Eag homolog \| Eag-related protein 1 \| ERG \| ERG-1 \| ERG1 \| Ether-a-go-go-related gene potassium channel 1 \| Ether-a-go-go-related protein 1 \| H-ERG \| HERG \| hERG-1 \| hERG1 \| Potassium voltage-gated channel subfamily H member 2 \| Voltage-gated potassium channel subunit Kv11.1 \| 1.14.14.- \| Cholesterol 25-hydroxylase \| CYP2DL1 \| CYPIID6 \| Cytochrome P450-DB1 \| Debrisoquine 4-hydroxylase	[ "Apo-sotalol", "Apo-sotalol", "Ava-sotalol", "Ava-sotalol", "Betapace", "Betapace", "Betapace", "Betapace", "Betapace", "Betapace", "Betapace", "Betapace", "Betapace", "Betapace", "Betapace AF", "Betapace AF", "Betapace AF", "Betapace AF", "Betapace AF", "Betapace AF", "Betapace AF", "Betapace AF", "Betapace AF", "Betapace AF", "Co Sotalol", "Co Sotalol", "Dom-sotalol", "Dom-sotalol", "Ftp-sotalol", "Ftp-sotalol", "Gen-sotalol 240mg", "Jamp-sotalol", "Jamp-sotalol", "Linsotalol - Tab 80mg", "Linsotalol -tab 160mg", "Med Sotalol", "Med Sotalol", "Mylan-sotalol", "Mylan-sotalol", "Novo-sotalol Tab 160mg", "Novo-sotalol Tab 80mg", "PHL-sotalol", "PHL-sotalol", "PMS-sotalol - 160 mg", "PMS-sotalol - 240 mg", "PMS-sotalol - 80 mg", "Pro-sotalol", "Pro-sotalol", "Ratio-sotalol", "Ratio-sotalol", "Rho-sotalol", "Rhoxal-sotalol", "Rhoxal-sotalol", "Riva-sotalol", "Riva-sotalol", "Riva-sotalol", "Riva-sotalol", "Rylosol", "Rylosol", "Rylosol", "Sandoz Sotalol", "Sandoz Sotalol", "Sorine", "Sorine", "Sorine", "Sorine", "Sorine", "Sotacor Tab 160mg", "Sotacor Tab 240mg", "Sotacor Tab 80mg", "Sotalol", "Sotalol", "Sotalol", "Sotalol", "Sotalol", "Sotalol", "Sotalol", "Sotalol", "Sotalol", "Sotalol", "Sotalol", "Sotalol", "Sotalol", "Sotalol", "Sotalol", "Sotalol", "Sotalol", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride", "Sotalol Hydrochloride AF", "Sotalol Hydrochloride AF", "Sotalol Hydrochloride AF", "Sotalol Hydrochloride AF", "Sotalol Hydrochloride AF", "Sotalol Hydrochloride AF", "Sotalol-160 - Tab 160mg", "Sotalol-80 - Tab 80mg", "Sotamol", "Sotamol", "Sotylize" ]	[ "Biosotal", "Cardol", "Darob", "Darob mite", "Hipecor", "Loritmik", "Rytmobeta", "Sotacor", "Sotagard", "Sotalex", "Sotapor", "Talozin", "Tan Shi", "Xi An Lin" ]	[]	[ "P08588", "P07550", "Q12809" ]	[ "P10635" ]	[]	[]
DB00490	Buspirone	Buspirone is a novel anxiolytic agent with a unique structure and a pharmacological profile. Belonging to the azaspirodecanedione drug class,[A180991] buspirone is a serotonin 5-HT<sub>1A</sub> receptor agonist that is not chemically or pharmacologically related to benzodiazepines, barbiturates, and other sedative/anxiolytic drugs.[L4478] Unlike many drugs used to treat anxiety, buspirone does not exhibit anticonvulsant, sedative, hypnotic, and muscle-relaxant properties. Due to these characteristics, buspirone been termed 'anxioselective'.[A180985] First synthesized in 1968 then patented in 1975,[L7375] it is commonly marketed under the brand name Buspar®. Buspirone was first approved in 1986 by the FDA [A181751] and has been used to treat anxiety disorders, such as generalized anxiety disorder (GAD), and relieve symptoms of anxiety. It has also been used as a second-line therapy for unipolar depression when the use of selective serotonin reuptake inhibitors (SSRIs) is deemed clinically inadequate or inappropriate.[L7375] The potential use of buspirone in combination with [melatonin] in depression and cognitive impairment via promoting neurogenesis has also been investigated.[A181751]	solid	Indicated for the management of anxiety disorders or the short-term relief of the symptoms of anxiety.[L4478]	The clinical effect of buspirone in alleviating the symptoms of generalized anxiety disorders typically takes 2 to 4 weeks to achieve.[L7375] The delayed onset of action of buspirone suggests that the therapeutic effectiveness in generalized anxiety may involved more than its molecular mechanism of action at the 5-HT<sub>1A</sub> receptors,[T28] or buspirone may induce adaptations of 5-HT<sub>1A</sub> receptors.[L7375] Buspirone was not shown to alter the psychomotor or cognitive function in healthy volunteers, and the risk of developing sedation is relatively low compared to other anxiolytics, such as benzodiazepines.[A180985] Unlike benzodiazepines and barbiturates used in anxiety disorders, buspirone is not associated with a risk for developing physical dependence or withdrawal, or any significant interaction with central nervous system depressants such as ethanol. This is due to the lack of effects on GABA receptors.[A180985,L7375] Buspirone also does not exhibit any anticonvulsant or muscle-relaxing properties,[A182309] but may interfere with arousal reactions due to its inhibitory action on the aactivity of noradrenergic locus coerulus neurons.[T28] Despite its clinical effectiveness in generalized anxiety, buspirone demonstrated limited clinical effectiveness on panic disorders, severe anxiety, phobias, and obsessive compulsive disorders.[A181751,T28] The clinical effectiveness of the long-term use of buspirone, for more than 3 to 4 weeks, has not demonstrated in controlled trials but there were no observable significant adverse events in patients receiving buspirone for a year in a study of long-term use.[L4478]	The therapeutic action of buspirone in generalized anxiety disorders is thought to be mainly derived from its interaction with two major 5-HT<sub>1A</sub> receptor subtypes that are involved in the brain's anxiety and fear circuitry to enhance the serotonergic activity in these brain areas.[L7375] Buspirone acts as a full agonist at presynaptic 5-HT<sub>1A</sub> receptors, or 5-HT<sub>1A</sub> autoreceptors, expressed at dorsal raphe while acting as a partial agonist at the postsynaptic 5-HT<sub>1A</sub> receptors expressed on hippocampus and cortex.[A182315,A182420] 5-HT<sub>1A</sub> receptors function as inhibitory autoreceptors by being expressed on the soma or dendrites of serotonergic neurons or mediate postsynaptic actions of 5-HT by being highly expressed on the corticolimbic circuits.[T28] They are inhibitory G-protein coupled receptors that couple to Gi/Go proteins. When activated, presynaptic 5-HT<sub>1A</sub> autoreceptors causes neuron hyperpolarization and reduces the firing rate of the serotonergic neuron, thereby decreasing extracellular 5-HT levels in the neuron's projection areas. Activated postsynaptic 5-HT<sub>1A</sub> receptors promote hyperpolarization to released 5-HT on pyramidal neurons.[A182420] The anxiolytic action of buspirone is mainly thought to arise from the interaction at presynaptic 5-HT<sub>1A</sub> autoreceptors. Acting as a potent agonist in these receptors, buspirone initially causes activation of these autoreceptors and inhibition of 5-HT release. It is proposed that buspirone induces desensitization of somatodendritic autoreceptors over time, which may explain the delayed onset of action of the drug. Desensitization of the autoreceptors ultimately results in heightened excitation of serotonergic neurons and enhanced 5-HT release.[T28] Buspirone also displays a weak affinity for serotonin 5HT2 receptors and acts as a weak antagonist on dopamine D2 autoreceptors,[L7375] although there is not much evidence that the action at these receptors contribute to the anxiolytic effect of buspirone.[A182312] It acts as an antagonist at presynaptic dopamine D3 and D4 receptors and may bind to alpha-1 adrenergic receptors as a partial agonist.[A181751]	Buspirone is rapidly absorbed following oral administration.[L4478] Bioavailability is low and variable (approximately 5%) due to extensive first pass metabolism. While absorption of buspirone is decreased with concomitant food intake, the first-pass metabolism of the drug is also decreased, resulting in an increased bioavailability [L7375] as well as increased Cmax and AUC.[L4478] Following oral administration of single oral doses of 20 mg, the Cmax ranged from 1 to 6 ng/mL and the Tmax ranged from 40 to 90 minutes.[L4478]	Buspirone is extensively metabolized upon administration, where it primarily undergoes hepatic oxidation mediated by the CYP3A4 enzyme. Hydroxylated derivatives are produced, including a pharmacologically active metabolite 1-pyrimidinylpiperazine (1-PP). In animal studies, 1-PP possessed about one quarter of the pharmacological activity of buspirone.[L4478]	The oral LD<sub>50</sub> of buspirone is 196 mg/kg in rat, 655 mg/kg in mouse, 586 mg/kg in dog, and 356 mg/kg in monkey. The intraperitoneal LD<sub>50</sub> is 136 mg/kg in rat and 146 mg/kg in mouse.[L4478,L7381] In clinical pharmacology trials, administration of buspirone at the dose of 375 mg/day resulted in symptoms of nausea, vomiting, dizziness, drowsiness, miosis, and gastric distress. Few cases of overdosage that have been reported usually resulted in complete recovery. In case of overdose, the use of general symptomatic and supportive treatment is recommended along with immediate gastric lavage and monitoring of respiration, pulse, and blood pressure.[L4478]	In a single-dose pharmacokinetic study of 14C-labeled buspirone, the average elimination half-life of unchanged buspirone following administration of single doses ranging from 10 to 40 mg was about 2 to 3 hours.[L4478]	Based on the findings of an _in vitro_ protein binding study, approximately 86% of buspirone is bound to plasma proteins.[L4478] It is mainly bound to serum albumin and alpha-1-acid glycoprotein.[A180991]	A single-dose pharmacokinetic studies using 14C-labeled buspirone demonstrated that about 29-63% of the dose administered was excreted in the urine within 24 hours, primarily in the form of metabolites. About 18% to 38% of the dose was eliminated via fecal excretion.[L4478]	In a pharmacokinetic study assessing buspirone over the dose range of 10 to 40 mg, the volume of distribution was 5.3 L/kg.[A181027]	In a pharmacokinetic study assessing buspirone over the dose range of 10 to 40 mg, the systemic clearance was 1.7 L/h/kg.[A181027]	Organic compounds	Organoheterocyclic compounds	Diazinanes	Piperazines	[ "approved", "investigational" ]	[ "N05BE", "N05B", "N05", "N" ]	[ "Humans and other mammals" ]	[ { "cost": "1.12", "description": "Buspar 10 mg Tablet", "unit": "tablet" }, { "cost": "1.18", "description": "Buspar 5 mg tablet", "unit": "tablet" }, { "cost": "1.18", "description": "Vanspar 7.5 mg tablet", "unit": "tablet" }, { "cost": "1.42", "description": "Buspirone hcl 10 mg tablet", "unit": "tablet" }, { "cost": "1.62", "description": "Buspirone hcl 7.5 mg tablet", "unit": "tablet" }, { "cost": "2.05", "description": "Buspar 10 mg tablet", "unit": "tablet" }, { "cost": "2.16", "description": "Buspirone hcl 15 mg tablet", "unit": "tablet" }, { "cost": "3.07", "description": "Buspar 15 mg tablet", "unit": "tablet" }, { "cost": "3.71", "description": "Buspirone hcl 30 mg tablet", "unit": "tablet" }, { "cost": "4.74", "description": "Buspirone hcl powder", "unit": "g" }, { "cost": "5.52", "description": "Buspar 30 mg tablet", "unit": "tablet" }, { "cost": "6.58", "description": "Wellbutrin xl 150 mg tablet", "unit": "tablet" }, { "cost": "8.68", "description": "Wellbutrin xl 300 mg tablet", "unit": "tablet" }, { "cost": "0.62", "description": "Apo-Buspirone 10 mg Tablet", "unit": "tablet" }, { "cost": "0.62", "description": "Novo-Buspirone 10 mg Tablet", "unit": "tablet" }, { "cost": "0.62", "description": "Nu-Buspirone 10 mg Tablet", "unit": "tablet" }, { "cost": "0.62", "description": "Pms-Buspirone 10 mg Tablet", "unit": "tablet" }, { "cost": "0.62", "description": "Ratio-Buspirone 10 mg Tablet", "unit": "tablet" }, { "cost": "0.79", "description": "Buspirone hcl 5 mg tablet", "unit": "tablet" } ]	[]	8-(4-(4-(2-Pyrimidinyl)-1-piperizinyl)butyl)-8-azaspiro(4,5)decane-7,9-dione \| Buspiron \| Buspirona \| Buspirone \| Buspironum \| 5-HT-1A \| 5-HT1A \| ADRB2RL1 \| ADRBRL1 \| G-21 \| Serotonin receptor 1A \| Dopamine D2 receptor \| Dopamine D3 receptor \| D(2C) dopamine receptor \| Dopamine D4 receptor \| ADRA1C \| Alpha-1A adrenoceptor \| Alpha-1A adrenoreceptor \| Alpha-1C adrenergic receptor \| Alpha-adrenergic receptor 1c \| Alpha-1B adrenoceptor \| Alpha-1B adrenoreceptor \| ADRA1A \| Alpha-1A adrenergic receptor \| Alpha-1D adrenoceptor \| Alpha-1D adrenoreceptor \| Alpha-adrenergic receptor 1a \| 1,4-cineole 2-exo-monooxygenase \| 1,8-cineole 2-exo-monooxygenase \| 1.14.14.1 \| Albendazole monooxygenase (sulfoxide-forming) \| Albendazole sulfoxidase \| Cholesterol 25-hydroxylase \| CYP3A3 \| CYPIIIA3 \| CYPIIIA4 \| Cytochrome P450 3A3 \| Cytochrome P450 HLp \| Cytochrome P450 NF-25 \| Cytochrome P450-PCN1 \| Nifedipine oxidase \| Quinine 3-monooxygenase \| 1.14.14.1 \| CYPIIIA5 \| Cytochrome P450-PCN3 \| 1.14.14.1 \| CYPIIIA7 \| Cytochrome P450-HFLA \| P450HLp2 \| 1.14.14.- \| Cholesterol 25-hydroxylase \| CYP2DL1 \| CYPIID6 \| Cytochrome P450-DB1 \| Debrisoquine 4-hydroxylase \| AGP 1 \| AGP1 \| OMD 1 \| Orosomucoid-1 \| ATP-binding cassette sub-family B member 1 \| MDR1 \| Multidrug resistance protein 1 \| P-glycoprotein 1 \| PGY1 \| Phospholipid transporter ABCB1	[ "Amb-buspirone", "Apo-buspirone", "Auro-buspirone", "Buspar", "Buspar", "Buspar", "Buspar", "Buspar", "Buspar", "Buspar", "Buspar", "Buspar Tab 10mg", "Buspirone", "Buspirone", "Buspirone", "Buspirone", "Buspirone HCl", "Buspirone HCl", "Buspirone HCl", "Buspirone HCl", "BUSPIRONE HCl", "Buspirone HCl", "Buspirone HCl", "Buspirone HCl", "Buspirone HCl", "Buspirone HCl", "Buspirone HCl", "Buspirone HCl", "Buspirone HCl", "Buspirone HCl", "Buspirone HCl", "Buspirone HCl", "Buspirone HCl", "Buspirone HCl", "Buspirone HCl", "Buspirone HCl", "Buspirone HCl", "Buspirone HCl", "Buspirone HCl", "Buspirone HCl", "Buspirone HCl", "Buspirone HCl", "Buspirone HCl", "Buspirone HCl", "Buspirone HCl", "Buspirone HCl", "Buspirone HCl", "Buspirone HCl", "Buspirone HCl", "Buspirone HCl", "busPIRone HCl", "busPIRone HCl", "busPIRone HCl", "busPIRone HCl", "busPIRone HCl", "Buspirone Hcl", "busPIRone HCl", "busPIRone HCl", "Buspirone HCl", "Buspirone HCl", "busPIRone HCl", "Buspirone HCl", "Buspirone HCl", "Buspirone HCl", "Buspirone HCl", "Buspirone HCl", "Buspirone HCl", "busPIRone HCl", "busPIRone HCl", "busPIRone HCl", "busPIRone HCl", "busPIRone HCl", "Buspirone Hcl", "busPIRone HCl", "Buspirone HCL", "Buspirone HCL", "busPIRone HCl", "busPIRone HCl", "busPIRone HCl", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "BusPIRone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone hydrochloride", "Buspirone hydrochloride", "Buspirone hydrochloride", "Buspirone hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "BusPIRone Hydrochloride", "BusPIRone Hydrochloride", "BusPIRone Hydrochloride", "BusPIRone Hydrochloride", "BusPIRone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "BusPIRone Hydrochloride", "BusPIRone Hydrochloride", "BusPIRone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone hydrochloride", "Buspirone hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "BusPIRone Hydrochloride", "BusPIRone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone hydrochloride", "Buspirone hydrochloride", "Buspirone hydrochloride", "Buspirone hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone hydrochloride", "Buspirone hydrochloride", "Buspirone hydrochloride", "Buspirone hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone hydrochloride", "Buspirone Hydrochloride", "Buspirone hydrochloride", "Buspirone hydrochloride", "Buspirone hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone hydrochloride", "Buspirone hydrochloride", "Buspirone hydrochloride", "Buspirone hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone hydrochloride", "Buspirone Hydrochloride", "Buspirone hydrochloride", "BusPIRone Hydrochloride", "Buspirone hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone hydrochloride", "Buspirone hydrochloride", "Buspirone Hydrochloride", "Buspirone hydrochloride", "Buspirone Hydrochloride", "Buspirone hydrochloride", "Buspirone hydrochloride", "Buspirone Hydrochloride", "Buspirone hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone hydrochloride", "Buspirone hydrochloride", "Buspirone hydrochloride", "Buspirone hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "BusPIRone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone hydrochloride", "Buspirone Hydrochloride", "Buspirone hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone hydrochloride", "Buspirone hydrochloride", "Buspirone hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride", "Buspirone Hydrochloride Tablets, USP", "Bustab", "Bustab", "Co Buspirone", "Dom-buspirone", "Ftp-buspirone", "Jamp Buspirone", "Linbuspirone", "Mint-buspirone", "Mylan-buspirone", "Penta-buspirone", "PMS-buspirone", "PMS-buspirone", "Pro-buspirone", "Pro-buspirone", "Ratio-buspirone", "Riva-buspirone 10 mg", "Teva-buspirone" ]	[ "Ansial", "Anxiron", "Anxut", "Bespar", "Buscalm", "Busp", "Buspon", "Dalpas", "Epsilat", "Pasrin", "Spamilan" ]	[]	[ "P08908", "P14416", "P35462", "P21917", "P35348", "P35368", "P25100" ]	[ "P08684", "P20815", "P24462", "P10635" ]	[ "P02768", "P02763" ]	[ "P08183" ]
DB00491	Miglitol	Miglitol inhibits the breakdown complex carbohydrates into glucose. It is primarily used in diabetes mellitus type 2 for establishing greater glycemic control by preventing the digestion of carbohydrates (such as disaccharides, oligosaccharides, and polysaccharides) into monosaccharides which can be absorbed by the body. Miglitol should be taken at the start of a meal for maximal effect and the effect will depend on the amount of poly and oligosaccharides in the diet. Miglitol inhibits alpha-glucosidase, making less sugars available for digestion and reducing postprandial hyperglycemia. Unlike other drugs of the same class, miglitol is not metabolized and the unmetabolized drug is excreted by the kidneys.	solid	For use as an adjunct to diet to improve glycemic control in patients with non-insulin-dependent diabetes mellitus (NIDDM) whose hyperglycemia cannot be managed with diet alone.	Miglitol, an oral alpha-glucosidase inhibitor, is a desoxynojirimycin derivative that delays the digestion of ingested carbohydrates, thereby resulting in a smaller rise in blood glucose concentration following meals. As a consequence of plasma glucose reduction, miglitol reduce levels of glycosylated hemoglobin in patients with Type II (non-insulin-dependent) diabetes mellitus. Systemic nonenzymatic protein glycosylation, as reflected by levels of glycosylated hemoglobin, is a function of average blood glucose concentration over time. Because its mechanism of action is different, the effect of miglitol to enhance glycemic control is additive to that of sulfonylureas when used in combination. In addition, miglitol diminishes the insulinotropic and weight-increasing effects of sulfonylureas. Miglitol has minor inhibitory activity against lactase and consequently, at the recommended doses, would not be expected to induce lactose intolerance.	In contrast to sulfonylureas, miglitol does not enhance insulin secretion. The antihyperglycemic action of miglitol results from a reversible inhibition of membrane-bound intestinal a-glucoside hydrolase enzymes. Membrane-bound intestinal a-glucosidases hydrolyze oligosaccharides and disaccharides to glucose and other monosaccharides in the brush border of the small intestine. In diabetic patients, this enzyme inhibition results in delayed glucose absorption and lowering of postprandial hyperglycemia.	Absorption of miglitol is saturable at high doses with 25 mg being completely absorbed while a 100-mg dose is only 50-70% absorbed. No evidence exists to show that systemic absorption of miglitol adds to its therapeutic effect.	Miglitol is not metabolized in man or in any animal species studied.	Unlike sulfonylureas or insulin, an overdose will not result in hypoglycemia. An overdose may result in transient increases in flatulence, diarrhea, and abdomi-nal discomfort. Because of the lack of extra-intestinal effects seen with miglitol, no serious systemic reactions are expected in the event of an overdose.	The elimination half-life of miglitol from plasma is approximately 2 hours.	The protein binding of miglitol is negligible (<4.0%).	Miglitol is not metabolized in man or in any animal species studied. It is eliminated by renal excretion as an unchanged drug.	* 0.18 L/kg	null	Organic compounds	Organoheterocyclic compounds	Piperidines	null	[ "approved" ]	[ "A10BF", "A10B", "A10", "A" ]	[ "Humans and other mammals" ]	[ { "cost": "1.11", "description": "Glyset 25 mg tablet", "unit": "tablet" }, { "cost": "1.24", "description": "Glyset 50 mg tablet", "unit": "tablet" }, { "cost": "1.46", "description": "Glyset 100 mg tablet", "unit": "tablet" } ]	[]	Miglitol \| Miglitolum \| 3.2.1.20 \| Acid maltase \| Aglucosidase alfa \| 3.2.1.207 \| Alpha-glucosidase 2 \| G2AN \| Glucosidase II subunit alpha \| KIAA0088 \| 3.2.1.20 \| Alpha-1,4-glucosidase \| MGA \| MGAML \| 1,4-alpha-D-glucan glucanohydrolase \| 3.2.1.1 \| PA	[ "Glyset", "Glyset", "Glyset", "Glyset", "Miglitol", "Miglitol", "Miglitol", "Miglitol", "Miglitol", "Miglitol", "Miglitol", "Miglitol", "Miglitol", "Miglitol", "Miglitol", "Miglitol" ]	[ "Diaban", "Diamig", "Diaset", "Diastabol", "Elitox", "Euglitol", "Glycet", "Laiping", "Migbose", "Miglit", "Mignar", "Migtor", "Misobit", "Plumarol", "Seibule" ]	[]	[ "P10253", "Q14697", "Q8TET4", "O43451" ]	[ "P04746" ]	[]	[]
DB00492	Fosinopril	Fosinopril is a phosphinic acid-containing ester prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is rapidly hydrolyzed to fosinoprilat, its principle active metabolite. Fosinoprilat inhibits ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Fosinopril may be used to treat mild to moderate hypertension, as an adjunct in the treatment of congestive heart failure, and to slow the rate of progression of renal disease in hypertensive individuals with diabetes mellitus and microalbuminuria or overt nephropathy.	solid	For treating mild to moderate hypertension, use as an adjunct in treating congestive heart failure, and may be used to slow the rate of progression of renal disease in hypertensive individuals with diabetes mellitus and microalbuminuria or overt nephropathy.	Following oral administration, fosinopril is rapidly and completely hydrolyzed to its principle active metabolite, fosinoprilat. Hydrolysis is thought to occur in the gastrointestinal mucosa and liver. Fosinoprilat is a competitive inhibitor of ACE, a peptidyl dipeptidase that is part of the RAAS. The RAAS is a homeostatic mechanism for regulating hemodynamics, water and electrolyte balance. During sympathetic stimulation or when renal blood pressure or blood flow is reduced, renin is released from the granular cells of the juxtaglomerular apparatus in the kidneys. In the blood stream, renin cleaves circulating angiotensinogen to ATI, which is subsequently cleaved to ATII by ACE. ATII increases blood pressure using a number of mechanisms. First, it stimulates the secretion of aldosterone from the adrenal cortex. Aldosterone travels to the distal convoluted tubule (DCT) and collecting tubule of nephrons where it increases sodium and water reabsorption by increasing the number of sodium channels and sodium-potassium ATPases on cell membranes. Second, ATII stimulates the secretion of vasopressin (also known as antidiuretic hormone or ADH) from the posterior pituitary gland. ADH stimulates further water reabsorption from the kidneys via insertion of aquaporin-2 channels on the apical surface of cells of the DCT and collecting tubules. Third, ATII increases blood pressure through direct arterial vasoconstriction. Stimulation of the Type 1 ATII receptor on vascular smooth muscle cells leads to a cascade of events resulting in myocyte contraction and vasoconstriction. In addition to these major effects, ATII induces the thirst response via stimulation of hypothalamic neurons. ACE inhibitors inhibit the rapid conversion of ATI to ATII and antagonize RAAS-induced increases in blood pressure. ACE (also known as kininase II) is also involved in the enzymatic deactivation of bradykinin, a vasodilator. Inhibiting the deactivation of bradykinin increases bradykinin levels and may further sustain the effects of fosinoprilat by causing increased vasodilation and decreased blood pressure.	There are two isoforms of ACE: the somatic isoform, which exists as a glycoprotein comprised of a single polypeptide chain of 1277; and the testicular isoform, which has a lower molecular mass and is thought to play a role in sperm maturation and binding of sperm to the oviduct epithelium. Somatic ACE has two functionally active domains, N and C, which arise from tandem gene duplication. Although the two domains have high sequence similarity, they play distinct physiological roles. The C-domain is predominantly involved in blood pressure regulation while the N-domain plays a role in hematopoietic stem cell differentiation and proliferation. ACE inhibitors bind to and inhibit the activity of both domains, but have much greater affinity for and inhibitory activity against the C-domain. Fosinoprilat, the active metabolite of fosinopril, competes with ATI for binding to ACE and inhibits and enzymatic proteolysis of ATI to ATII. Decreasing ATII levels in the body decreases blood pressure by inhibiting the pressor effects of ATII as described in the Pharmacology section above. Fosinoprilat also causes an increase in plasma renin activity likely due to a loss of feedback inhibition mediated by ATII on the release of renin and/or stimulation of reflex mechanisms via baroreceptors.	Average absolute absorption is 36%. The primary site of absorption is the proximal small intestine (duodenum/jejunum). Food slows the rate of absorption with no effect on the extent of absorption.	Since fosinoprilat is not biotransformed after intravenous administration, fosinopril, not fosinoprilat, appears to be the precursor for the glucuronide and p-hydroxy metabolites.	Human overdoses of fosinopril have not been reported, but the most common manifestation of human fosinopril overdosage is likely to be hypotension. Oral doses of fosinopril at 2600 mg/kg in rats were associated with significant lethality. The most common adverse effects include dizzines, cough, fatigue, and headache.	12 hours	Fosinoprilat is ≥95% protein bound	After oral administration of radiolabeled fosinopril, approximately half of the absorbed dose is excreted in the urine and the remainder is excreted in the feces.	null	* 26 - 39 mL/min [healthy]	null	null	null	null	[ "approved" ]	[ "C09BA", "C09B", "C09", "C", "C09AA", "C09A", "C09", "C" ]	[ "Humans and other mammals" ]	[ { "cost": "1.1", "description": "Monopril 20 mg Tablet", "unit": "tablet" }, { "cost": "1.21", "description": "Fosinopril sodium 10 mg tablet", "unit": "tablet" }, { "cost": "1.25", "description": "Fosinopril sodium 20 mg tablet", "unit": "tablet" }, { "cost": "1.25", "description": "Fosinopril sodium 40 mg tablet", "unit": "tablet" }, { "cost": "1.61", "description": "Fosinopril Sodium-HCTZ 10-12.5 mg tablet", "unit": "tablet" }, { "cost": "1.61", "description": "Fosinopril Sodium-HCTZ 20-12.5 mg tablet", "unit": "tablet" }, { "cost": "1.62", "description": "Monopril 20 mg tablet", "unit": "tablet" }, { "cost": "1.67", "description": "Monopril 40 mg tablet", "unit": "tablet" }, { "cost": "1.68", "description": "Monopril 10 mg tablet", "unit": "tablet" }, { "cost": "1.71", "description": "Monopril HCT 10-12.5 mg tablet", "unit": "tablet" }, { "cost": "0.51", "description": "Apo-Fosinopril 10 mg Tablet", "unit": "tablet" }, { "cost": "0.51", "description": "Fosinopril 10 mg Tablet", "unit": "tablet" }, { "cost": "0.51", "description": "Jamp-Fosinopril 10 mg Tablet", "unit": "tablet" }, { "cost": "0.51", "description": "Mylan-Fosinopril 10 mg Tablet", "unit": "tablet" }, { "cost": "0.51", "description": "Novo-Fosinopril 10 mg Tablet", "unit": "tablet" }, { "cost": "0.51", "description": "Ran-Fosinopril 10 mg Tablet", "unit": "tablet" }, { "cost": "0.61", "description": "Apo-Fosinopril 20 mg Tablet", "unit": "tablet" }, { "cost": "0.61", "description": "Fosinopril 20 mg Tablet", "unit": "tablet" }, { "cost": "0.61", "description": "Jamp-Fosinopril 20 mg Tablet", "unit": "tablet" }, { "cost": "0.61", "description": "Mylan-Fosinopril 20 mg Tablet", "unit": "tablet" }, { "cost": "0.61", "description": "Novo-Fosinopril 20 mg Tablet", "unit": "tablet" }, { "cost": "0.61", "description": "Ran-Fosinopril 20 mg Tablet", "unit": "tablet" }, { "cost": "0.91", "description": "Monopril 10 mg Tablet", "unit": "tablet" } ]	[ { "approved": "1991-04-09", "country": "United States", "expires": "2010-01-10", "number": "5006344" } ]	Fosenopril \| Fosinopril \| 3.4.15.1 \| ACE \| DCP \| DCP1 \| Dipeptidyl carboxypeptidase I \| Kininase II \| Intestinal H(+)/peptide cotransporter \| Oligopeptide transporter, small intestine isoform \| PEPT1 \| Peptide transporter 1 \| Kidney H(+)/peptide cotransporter \| Oligopeptide transporter, kidney isoform \| PEPT2 \| Peptide transporter 2	[ "Apo-fosinopril", "Apo-fosinopril", "Ava-fosinopril", "Ava-fosinopril", "Fosinopril", "Fosinopril", "FOSINOPRIL Na", "FOSINOPRIL Na", "FOSINOPRIL Na", "Fosinopril Sodium", "Fosinopril Sodium", "Fosinopril Sodium", "Fosinopril Sodium", "Fosinopril Sodium", "Fosinopril Sodium", "Fosinopril Sodium", "Fosinopril Sodium", "Fosinopril Sodium", "Fosinopril Sodium", "Fosinopril Sodium", "Fosinopril Sodium", "Fosinopril Sodium", "Fosinopril Sodium", "Fosinopril sodium", "Fosinopril sodium", "Fosinopril sodium", "Fosinopril Sodium", "Fosinopril Sodium", "Fosinopril Sodium", "Fosinopril Sodium", "Fosinopril Sodium", "Fosinopril Sodium", "Fosinopril sodium", "Fosinopril sodium", "Fosinopril Sodium", "Fosinopril Sodium", "Fosinopril Sodium", "Fosinopril Sodium", "Fosinopril Sodium", "Fosinopril Sodium", "Fosinopril Sodium", "Fosinopril Sodium", "Fosinopril sodium", "Fosinopril sodium", "Fosinopril Sodium", "Fosinopril Sodium", "Fosinopril Sodium", "Fosinopril Sodium", "Fosinopril Sodium", "Fosinopril Sodium", "Fosinopril Sodium", "Fosinopril Sodium", "Fosinopril Sodium", "Fosinopril Sodium", "Fosinopril Sodium", "Fosinopril Sodium", "Fosinopril Sodium", "Fosinopril Sodium", "Fosinopril sodium", "Fosinopril sodium", "Fosinopril sodium", "Fosinopril Sodium", "Fosinopril Sodium", "Fosinopril Sodium", "Fosinopril Sodium", "Fosinopril Sodium", "Fosinopril Sodium", "Fosinopril Sodium", "Fosinopril Sodium", "Fosinopril Sodium", "Fosinopril Sodium", "Fosinopril Sodium", "Fosinopril Sodium", "Fosinopril Sodium", "Fosinopril Sodium", "Fosinopril sodium", "Fosinopril sodium", "Fosinopril sodium", "Fosinopril sodium", "Fosinopril sodium", "Fosinopril Sodium", "Fosinopril Sodium", "Fosinopril sodium", "Fosinopril sodium", "Fosinopril sodium", "Fosinopril Sodium", "Fosinopril Sodium", "Fosinopril Sodium", "Fosinopril sodium", "Fosinopril sodium", "Fosinopril Sodium", "Fosinopril sodium", "Fosinopril sodium", "Fosinopril sodium", "Fosinopril sodium", "Fosinopril Sodium", "Fosinopril Sodium", "Fosinopril Sodium", "Fosinopril sodium", "Fosinopril Sodium", "Fosinopril Sodium", "Fosinopril Sodium", "Fosinopril Sodium and Hydrochlorothiazide", "Fosinopril Sodium and Hydrochlorothiazide", "Fosinopril Sodium and Hydrochlorothiazide", "Fosinopril Sodium and Hydrochlorothiazide", "Fosinopril Sodium and Hydrochlorothiazide", "Fosinopril Sodium and Hydrochlorothiazide", "Fosinopril Sodium and Hydrochlorothiazide", "Fosinopril Sodium and Hydrochlorothiazide", "Fosinopril Sodium and Hydrochlorothiazide", "Fosinopril Sodium and Hydrochlorothiazide", "Fosinopril Sodium and Hydrochlorothiazide", "Fosinopril Sodium and Hydrochlorothiazide", "Fosinopril Sodium and Hydrochlorothiazide", "Fosinopril Sodium and Hydrochlorothiazide", "Fosinopril Sodium and Hydrochlorothiazide", "Fosinopril Sodium and Hydrochlorothiazide", "Fosinopril Sodium and Hydrochlorothiazide", "Fosinopril Sodium and Hydrochlorothiazide", "Fosinopril Sodium and Hydrochlorothiazide", "Fosinopril Sodium and Hydrochlorothiazide", "Fosinopril Sodium and Hydrochlorothiazide", "Fosinopril Sodium and Hydrochlorothiazide", "Fosinopril Sodium and Hydrochlorothiazide", "Fosinopril Sodium and Hydrochlorothiazide", "Fosinopril Sodium and Hydrochlorothiazide", "Fosinopril Sodium and Hydrochlorothiazide", "Fosinopril Sodium and Hydrochlorothiazide", "Fosinopril Tablets", "Fosinopril Tablets", "Fosinopril-10", "Fosinopril-20", "Jamp-fosinopril", "Jamp-fosinopril", "Lin-fosinopril", "Lin-fosinopril", "Monopril", "Monopril", "Monopril", "Monopril", "Monopril", "Monopril Tab 10mg", "Monopril Tab 20mg", "Monopril-hct", "Monopril-hct", "Mylan-fosinopril", "Mylan-fosinopril", "Nu-fosinopril", "Nu-fosinopril", "PHL-fosinopril", "PHL-fosinopril", "PMS-fosinopril", "PMS-fosinopril", "Ran-fosinopril", "Ran-fosinopril", "Ratio Fosinopril", "Ratio Fosinopril", "Riva-fosinopril", "Riva-fosinopril", "Teva-fosinopril", "Teva-fosinopril" ]	[ "Acecor", "Monopril", "Staril" ]	[ "Fosinopril Sodium and Hydrochlorothiazide", "Fosinopril Sodium and Hydrochlorothiazide", "Fosinopril Sodium and Hydrochlorothiazide", "Fosinopril Sodium and Hydrochlorothiazide", "Monopril-hct", "Monopril-hct", "Fosinopril Sodium and Hydrochlorothiazide", "Fosinopril Sodium and Hydrochlorothiazide", "Fosinopril Sodium and Hydrochlorothiazide", "Fosinopril Sodium and Hydrochlorothiazide", "Fosinopril Sodium and Hydrochlorothiazide", "Fosinopril Sodium and Hydrochlorothiazide", "Fosinopril Sodium and Hydrochlorothiazide", "Fosinopril Sodium and Hydrochlorothiazide", "Fosinopril Sodium and Hydrochlorothiazide", "Fosinopril Sodium and Hydrochlorothiazide", "Fosinopril Sodium and Hydrochlorothiazide", "Fosinopril Sodium and Hydrochlorothiazide", "Fosinopril Sodium and Hydrochlorothiazide", "Fosinopril Sodium and Hydrochlorothiazide", "Fosinopril Sodium and Hydrochlorothiazide", "Fosinopril Sodium and Hydrochlorothiazide", "Fosinopril Sodium and Hydrochlorothiazide", "Fosinopril Sodium and Hydrochlorothiazide", "Fosinopril Sodium and Hydrochlorothiazide", "Fosinopril Sodium and Hydrochlorothiazide", "Fosinopril Sodium and Hydrochlorothiazide", "Fosinopril Sodium and Hydrochlorothiazide", "Fosinopril Sodium and Hydrochlorothiazide" ]	[ "P12821" ]	[]	[]	[ "P46059", "Q16348" ]
DB00493	Cefotaxime	Cefotaxime is a third-generation cephalosporin antibiotic. Like other third-generation cephalosporins, it has broad spectrum activity against Gram positive and Gram negative bacteria. In most cases, it is considered to be equivalent to ceftriaxone in terms of safety and efficacy. Cefotaxime sodium is marketed under various trade names including Claforan (Sanofi-Aventis).	solid	Used to treat gonorrhoea, meningitis, and severe infections including infections of the kidney (pyelonephritis) and urinary system. Also used before an operation to prevent infection after surgery.	Cefotaxime is a third generation intravenous cephalosporin antibiotic. It has broad spectrum activity against Gram positive and Gram negative bacteria. It does not have activity against <i>Pseudomonas aeruginosa</i>. Cefotaxime works by inhibiting bacterial cell wall biosynthesis. A positive feature of cefotaxime is that it display a resistance to penicillinases and is useful to treat infections that are resistant to penicillin derivatives.	The bactericidal activity of cefotaxime results from the inhibition of cell wall synthesis via affinity for penicillin-binding proteins (PBPs). Cefotaxime shows high affinity for penicillin-binding proteins in the cell wall including PBP Ib and PBP III.	Rapidly absorbed following intramuscular injection.	Approximately 20-36% of an intravenously administered dose of 14C-cefotaxime is excreted by the kidney as unchanged cefotaxime and 15-25% as the desacetyl derivative, the major metabolite. The desacetyl metabolite has been shown to contribute to the bactericidal activity. Two other urinary metabolites (M2 and M3) account for about 20-25%. They lack bactericidal activity.	Adverse effects following overdosage include nausea, vomiting, epigastric distress, diarrhea, and convulsions. Oral rat LD<sub>50</sub> is over 20,000 mg/kg while intravenous rat LD<sub>50</sub> is over 7,000 mg/kg.	Approximately 1 hour.	null	Approximately 20-36% of an intravenously administered dose of 14C-cefotaxime is excreted by the kidney as unchanged cefotaxime and 15-25% as the desacetyl derivative, the major metabolite.	null	null	Organic compounds	Organoheterocyclic compounds	Lactams	Beta lactams	[ "approved" ]	[ "J01DD", "J01D", "J01", "J" ]	[ "Streptococcus pneumoniae", "Streptococcus pyogenes", "Staphylococcus aureus", "Escherichia coli", "Klebsiella spp.", "Haemophilus influenzae", "Haemophilus parainfluenzae", "Proteus mirabilis", "Serratia marcescens", "Enterobacter spp.", "Pseudomonas aeruginosa", "Enterococcus", "Staphylococcus epidermidis", "Citrobacter spp.", "Proteus vulgaris", "Providencia stuartii", "Morganella morganii", "Providencia rettgeri", "Neisseria gonorrhoeae", "Bacteroides spp.", "Clostridium spp.", "Peptostreptococcus spp.", "Peptococcus spp.", "Fusobacterium spp.", "Acinetobacter spp." ]	[ { "cost": "2.12", "description": "Claforan 1 gm vial", "unit": "vial" }, { "cost": "3.24", "description": "Cefotaxime sodium 1 gm vial", "unit": "vial" }, { "cost": "5.74", "description": "Claforan 2 gm vial", "unit": "vial" }, { "cost": "6.08", "description": "Claforan 1 gm infusion btl", "unit": "each" }, { "cost": "6.48", "description": "Cefotaxime sodium 2 gm vial", "unit": "vial" }, { "cost": "6.76", "description": "Claforan 500 mg/vial", "unit": "vial" }, { "cost": "10.36", "description": "Claforan 1 g/vial", "unit": "vial" }, { "cost": "11.76", "description": "Claforan 2 gm infusion btl", "unit": "each" }, { "cost": "20.72", "description": "Claforan 2 g/vial", "unit": "vial" }, { "cost": "28.64", "description": "Claforan 10 gm vial", "unit": "vial" }, { "cost": "31.43", "description": "Cefotaxime sodium 10 gm vial", "unit": "vial" } ]	[]	(6R,7R,Z)-3-(acetoxymethyl)-7-(2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid \| (6R,7R)-3-(acetoxymethyl)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid \| (6R,7R)-3-Acetoxymethyl-7-{2-(2-amino-thiazol-4-yl)-2-[(Z)-methoxyimino]-acetylamino}-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid \| Cefotaxim \| Cefotaxima \| Cefotaxime \| Céfotaxime \| Cefotaximum \| Cephotaxime \| PBP 3 \| Penicillin-binding protein C \| PSPB20 \| ycsM \| yzsA \| exp2 \| Exported protein 2 \| PBP-1A \| pbp2b \| hOAT1 \| hPAHT \| hROAT1 \| OAT1 \| Organic anion transporter 1 \| PAH transporter \| PAHT \| Renal organic anion transporter 1 \| hOAT3 \| OAT3 \| Organic anion/dicarboxylate exchanger \| Solute carrier family 22 member 8 \| OAT4 \| Organic anion transporter 4 \| Organic anion:dicarboxylate exchanger OAT4 \| hOAT2 \| NLT \| Novel liver transporter \| OAT2 \| Organic anion transporter 2 \| Intestinal H(+)/peptide cotransporter \| Oligopeptide transporter, small intestine isoform \| PEPT1 \| Peptide transporter 1 \| 3.5.2.6 \| Kidney H(+)/peptide cotransporter \| Oligopeptide transporter, kidney isoform \| PEPT2 \| Peptide transporter 2 \| Intestinal H(+)/peptide cotransporter \| Oligopeptide transporter, small intestine isoform \| PEPT1 \| Peptide transporter 1 \| Kidney H(+)/peptide cotransporter \| Oligopeptide transporter, kidney isoform \| PEPT2 \| Peptide transporter 2 \| hOAT1 \| hPAHT \| hROAT1 \| OAT1 \| Organic anion transporter 1 \| PAH transporter \| PAHT \| Renal organic anion transporter 1 \| hOAT3 \| OAT3 \| Organic anion/dicarboxylate exchanger \| Solute carrier family 22 member 8 \| OAT4 \| Organic anion transporter 4 \| Organic anion:dicarboxylate exchanger OAT4 \| hOAT2 \| NLT \| Novel liver transporter \| OAT2 \| Organic anion transporter 2	[ "Cefotaxime", "Cefotaxime", "Cefotaxime", "Cefotaxime", "Cefotaxime", "Cefotaxime", "Cefotaxime", "Cefotaxime", "Cefotaxime", "Cefotaxime", "Cefotaxime", "Cefotaxime", "Cefotaxime", "Cefotaxime", "Cefotaxime", "Cefotaxime", "Cefotaxime", "Cefotaxime", "Cefotaxime", "Cefotaxime", "Cefotaxime", "Cefotaxime", "Cefotaxime", "Cefotaxime", "Cefotaxime", "Cefotaxime", "Cefotaxime and Dextrose", "Cefotaxime and Dextrose", "Cefotaxime for Injection USP", "Cefotaxime for Injection USP", "Cefotaxime for Injection USP", "Cefotaxime Sodium for Injection BP", "Cefotaxime Sodium for Injection BP", "Cefotaxime Sodium for Injection BP", "Cefotaxime Sodium for Injection, BP", "Cefotaxime Sodium for Injection, BP", "Cefotaxime Sodium for Injection, BP", "Cefotaxime Sodium for Injection, BP", "Cefotaxime Sodium for Injection, BP", "Cefotaxime Sodium for Injection, BP", "Cefotaxime Sodium for Injection, BP", "Cefotaxime Sodium Sterile", "Claforan", "Claforan", "Claforan", "Claforan", "Claforan", "Claforan", "Claforan", "Claforan", "Claforan", "Claforan", "Claforan - Pws Inj 1.0g/vial", "Claforan - Pws Inj 2.0g/vial", "Claforan - Pws Inj 500mg/vial", "Claforan 0.5gm/vial", "Claforan 1gm/vial", "Claforan 2gm/vial", "Claforan Add-vantage Vials 1gm/vial", "Claforan Inj 1gm/add-vantage Vial", "Claforan Pws Inj 1.0gm/vial", "Claforan Pws Inj 2.0gm/vial", "Claforan Pws Inj 500mg/vial" ]	[ "Rantaksym", "Raxim", "Spinocef", "Sporim", "Talcef" ]	[]	[ "Q4U2R8", "Q8TCC7", "Q9NSA0", "Q9Y694", "P46059", "P02768", "Q16348" ]	[]	[]	[ "P46059", "Q16348", "Q4U2R8", "Q8TCC7", "Q9NSA0", "Q9Y694" ]
DB00494	Entacapone	Entacapone is a selective, reversible catechol-O-methyl transferase (COMT) inhibitor for the treatment of Parkinson's disease. It is a member of the class of nitrocatechols. When administered concomittantly with levodopa and a decarboxylase inhibitor (e.g., carbidopa), increased and more sustained plasma levodopa concentrations are reached as compared to the administration of levodopa and a decarboxylase inhibitor.	solid	Used as an adjunct to levodopa / carbidopa in the symptomatic treatment of patients with idiopathic Parkinson's Disease who experience the signs and symptoms of end-of-dose "wearing-off".	Entacapone is structurally and pharmacologically related to tolcapone, but unlike tolcapone, is not associated with hepatotoxicity. Entacapone is used in the treatment of Parkinson’s disease as an adjunct to levodopa/carbidopa therapy. Entacapone selectively and reversiblly inhibits catechol-O-methyltransferase (COMT). In mammals, COMT is distributed throughout various organs with the highest activities in the liver and kidney. COMT also occurs in the heart, lung, smooth and skeletal muscles, intestinal tract, reproductive organs, various glands, adipose tissue, skin, blood cells and neuronal tissues, especially in glial cells. COMT catalyzes the transfer of the methyl group of S-adenosyl-L-methionine to the phenolic group of substrates that contain a catechol structure. Physiological substrates of COMT include dopa, catecholamines (dopamine, norepinephrine, and epinephrine) and their hydroxylated metabolites. The function of COMT is the elimination of biologically active catechols and some other hydroxylated metabolites. COMT is responsible for the elimination of biologically active catechols and some other hydroxylated metabolites. In the presence of a decarboxylase inhibitor, COMT becomes the major metabolizing enzyme for levodopa, catalyzing the it to 3-methoxy-4-hydroxy-L-phenylalanine (3-OMD) in the brain and periphery.	The mechanism of action of entacapone is believed to be through its ability to inhibit COMT in peripheral tissues, altering the plasma pharmacokinetics of levodopa. When entacapone is given in conjunction with levodopa and an aromatic amino acid decarboxylase inhibitor, such as carbidopa, plasma levels of levodopa are greater and more sustained than after administration of levodopa and an aromatic amino acid decarboxylase inhibitor alone. It is believed that at a given frequency of levodopa administration, these more sustained plasma levels of levodopa result in more constant dopaminergic stimulation in the brain, leading to a greater reduction in the manifestations of parkinsonian syndrome.	Entacapone is rapidly absorbed (approximately 1 hour). The absolute bioavailability following oral administration is 35%.	Metabolized via isomerization to the cis-isomer, followed by direct glucuronidation of the parent and cis-isomer.	Side effect include increase the occurrence of orthostatic hypotension, severe rhabdomyolysis, dyskinesia, hallucinations, hyperkinesia, hypokinesia, dizziness, fatigu,e gastrointestinal effects including abdominal pain constipation diarrhea nausea	0.4-0.7 hour	98% (bind to serum albumin)	Entacapone is almost completely metabolized prior to excretion, with only a very small amount (0.2% of dose) found unchanged in urine. As only about 10% of the entacapone dose is excreted in urine as parent compound and conjugated glucuronide, biliary excretion appears to be the major route of excretion of this drug.	* 20 L	* 850 mL/min	Organic compounds	Phenylpropanoids and polyketides	Cinnamic acids and derivatives	Hydroxycinnamic acids and derivatives	[ "approved", "investigational" ]	[ "N04BX", "N04B", "N04", "N" ]	[ "Humans and other mammals" ]	[ { "cost": "2.96", "description": "Comtan 200 mg tablet", "unit": "tablet" } ]	[ { "approved": "1992-08-04", "country": "United States", "expires": "2010-10-31", "number": "5135950" }, { "approved": "2008-01-29", "country": "Canada", "expires": "2019-09-13", "number": "2342634" }, { "approved": "1995-03-28", "country": "Canada", "expires": "2012-03-28", "number": "1334967" }, { "approved": "2003-07-29", "country": "United States", "expires": "2018-09-14", "number": "6599530" }, { "approved": "2002-12-31", "country": "United States", "expires": "2020-06-29", "number": "6500867" }, { "approved": "2004-09-28", "country": "United States", "expires": "2020-06-29", "number": "6797732" } ]	(E)-alpha-Cyano-N,N-diethyl-3,4-dihydroxy-5-nitrocinnamamide \| Entacapona \| Entacapone \| Entacaponum \| N,N-diethyl-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl) acrylamide \| 2.1.1.6 \| 1.14.14.- \| Cholesterol 25-hydroxylase \| CYP2DL1 \| CYPIID6 \| Cytochrome P450-DB1 \| Debrisoquine 4-hydroxylase \| 2.1.1.6 \| 2.4.1.17 \| GNT1 \| lugP4 \| UDP-glucuronosyltransferase 1-9 \| UDP-glucuronosyltransferase 1-I \| UDPGT 1-9 \| UGT-1I \| UGT1 \| UGT1-09 \| UGT1.9 \| UGT1*9 \| UGT1A9 \| UGT1I	[ "Apo-entacapone", "Auro-entacapone", "Carbidopa, Levodopa and Entacapone", "Carbidopa, Levodopa and Entacapone", "Carbidopa, Levodopa and Entacapone", "Carbidopa, Levodopa and Entacapone", "Carbidopa, Levodopa and Entacapone", "Carbidopa, Levodopa and Entacapone", "Carbidopa, levodopa and entacapone", "Carbidopa, levodopa and entacapone", "Carbidopa, Levodopa and Entacapone", "Carbidopa, Levodopa and Entacapone", "Carbidopa, Levodopa and Entacapone", "Carbidopa, Levodopa and Entacapone", "Carbidopa, Levodopa and Entacapone", "Carbidopa, Levodopa and Entacapone", "Carbidopa, levodopa and entacapone", "Carbidopa, levodopa and entacapone", "Carbidopa, levodopa and entacapone", "Carbidopa, levodopa and entacapone", "Carbidopa, levodopa and entacapone", "Carbidopa, levodopa and entacapone", "Carbidopa, Levodopa and Entacapone", "Carbidopa, Levodopa and Entacapone", "Carbidopa, Levodopa and Entacapone", "Carbidopa, Levodopa and Entacapone", "Carbidopa, Levodopa and Entacapone", "Carbidopa, Levodopa and Entacapone", "Carbidopa, Levodopa and Entacapone", "Carbidopa, Levodopa and Entacapone", "Carbidopa, Levodopa and Entacapone", "Carbidopa, Levodopa and Entacapone", "Carbidopa, Levodopa and Entacapone", "Carbidopa, Levodopa and Entacapone", "Carbidopa, Levodopa, and Entacapone", "Carbidopa, Levodopa, and Entacapone", "Carbidopa, Levodopa, and Entacapone", "Carbidopa, Levodopa, and Entacapone", "Carbidopa, Levodopa, and Entacapone", "Carbidopa, Levodopa, and Entacapone", "Comtan", "Comtan", "Comtan", "Comtan", "Comtan", "Comtan", "Comtan", "Comtan", "Comtan", "Comtan", "Comtess", "Comtess", "Comtess", "Comtess", "Corbilta", "Corbilta", "Corbilta", "Corbilta", "Corbilta", "Corbilta", "Corbilta", "Corbilta", "Corbilta", "Corbilta", "Corbilta", "Corbilta", "Corbilta", "Corbilta", "Corbilta", "Corbilta", "Corbilta", "Corbilta", "Corbilta", "Corbilta", "Corbilta", "Corbilta", "Corbilta", "Corbilta", "Corbilta", "Corbilta", "Corbilta", "Corbilta", "Corbilta", "Corbilta", "Corbilta", "Corbilta", "Corbilta", "Corbilta", "Corbilta", "Corbilta", "Corbilta", "Corbilta", "Entacapone", "Entacapone", "Entacapone", "Entacapone", "Entacapone", "Entacapone", "Entacapone", "Entacapone", "Entacapone", "Entacapone", "Entacapone", "Entacapone", "Entacapone", "Entacapone", "Entacapone", "Entacapone", "Entacapone", "Entacapone", "Entacapone", "Entacapone", "Entacapone", "Entacapone", "Entacapone", "Entacapone", "Entacapone", "Entacapone", "Entacapone", "Entacapone", "Entacapone Orion", "Entacapone Orion", "Entacapone Orion", "Entacapone Orion", "Entacapone Teva", "Entacapone Teva", "Entacapone Teva", "Entacapone Teva", "Levodopa, Carbidopa and Entacapone Tablets", "Levodopa, Carbidopa and Entacapone Tablets", "Levodopa/carbidopa/entacapone Orion", "Levodopa/carbidopa/entacapone Orion", "Levodopa/carbidopa/entacapone Orion", "Levodopa/carbidopa/entacapone Orion", "Levodopa/carbidopa/entacapone Orion", "Levodopa/carbidopa/entacapone Orion", "Levodopa/carbidopa/entacapone Orion", "Levodopa/carbidopa/entacapone Orion", "Levodopa/carbidopa/entacapone Orion", "Levodopa/carbidopa/entacapone Orion", "Levodopa/carbidopa/entacapone Orion", "Levodopa/carbidopa/entacapone Orion", "Levodopa/carbidopa/entacapone Orion", "Levodopa/carbidopa/entacapone Orion", "Levodopa/carbidopa/entacapone Orion", "Levodopa/carbidopa/entacapone Orion", "Levodopa/carbidopa/entacapone Orion", "Levodopa/carbidopa/entacapone Orion", "Levodopa/carbidopa/entacapone Orion", "Levodopa/carbidopa/entacapone Orion", "Levodopa/carbidopa/entacapone Orion", "Levodopa/carbidopa/entacapone Orion", "Levodopa/carbidopa/entacapone Orion", "Levodopa/carbidopa/entacapone Orion", "Levodopa/carbidopa/entacapone Orion", "Levodopa/carbidopa/entacapone Orion", "Levodopa/carbidopa/entacapone Orion", "Levodopa/carbidopa/entacapone Orion", "Levodopa/carbidopa/entacapone Orion", "Levodopa/carbidopa/entacapone Orion", "Levodopa/carbidopa/entacapone Orion", "Levodopa/carbidopa/entacapone Orion", "Levodopa/carbidopa/entacapone Orion", "Levodopa/carbidopa/entacapone Orion", "Levodopa/carbidopa/entacapone Orion", "Levodopa/carbidopa/entacapone Orion", "Levodopa/carbidopa/entacapone Orion", "Levodopa/carbidopa/entacapone Orion", "Mint-entacapone", "Mylan-entacapone", "Sandoz Entacapone", "Sandoz Levodopa-carbidopa-entacapone", "Sandoz Levodopa-carbidopa-entacapone", "Sandoz Levodopa-carbidopa-entacapone", "Sandoz Levodopa-carbidopa-entacapone", "Sandoz Levodopa-carbidopa-entacapone", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Teva-entacapone" ]	[ "Anxopone", "Comtade" ]	[ "Carbidopa, Levodopa and Entacapone", "Carbidopa, Levodopa and Entacapone", "Carbidopa, Levodopa and Entacapone", "Carbidopa, Levodopa and Entacapone", "Carbidopa, Levodopa and Entacapone", "Carbidopa, Levodopa and Entacapone", "Carbidopa, levodopa and entacapone", "Carbidopa, levodopa and entacapone", "Carbidopa, Levodopa and Entacapone", "Carbidopa, Levodopa and Entacapone", "Carbidopa, Levodopa and Entacapone", "Carbidopa, Levodopa and Entacapone", "Carbidopa, Levodopa and Entacapone", "Carbidopa, Levodopa and Entacapone", "Carbidopa, levodopa and entacapone", "Carbidopa, levodopa and entacapone", "Carbidopa, levodopa and entacapone", "Carbidopa, levodopa and entacapone", "Carbidopa, levodopa and entacapone", "Carbidopa, levodopa and entacapone", "Carbidopa, Levodopa, and Entacapone", "Carbidopa, Levodopa, and Entacapone", "Carbidopa, Levodopa, and Entacapone", "Carbidopa, Levodopa, and Entacapone", "Carbidopa, Levodopa, and Entacapone", "Carbidopa, Levodopa, and Entacapone", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Carbidopa, Levodopa and Entacapone", "Carbidopa, Levodopa and Entacapone", "Carbidopa, Levodopa and Entacapone", "Carbidopa, Levodopa and Entacapone", "Carbidopa, Levodopa and Entacapone", "Carbidopa, Levodopa and Entacapone", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Sandoz Levodopa-carbidopa-entacapone", "Sandoz Levodopa-carbidopa-entacapone", "Sandoz Levodopa-carbidopa-entacapone", "Sandoz Levodopa-carbidopa-entacapone", "Sandoz Levodopa-carbidopa-entacapone", "Levodopa, Carbidopa and Entacapone Tablets", "Levodopa, Carbidopa and Entacapone Tablets", "Carbidopa, Levodopa and Entacapone", "Carbidopa, Levodopa and Entacapone", "Carbidopa, Levodopa and Entacapone", "Carbidopa, Levodopa and Entacapone", "Carbidopa, Levodopa and Entacapone", "Carbidopa, Levodopa and Entacapone", "Corbilta", "Corbilta", "Corbilta", "Corbilta", "Corbilta", "Corbilta", "Corbilta", "Corbilta", "Corbilta", "Corbilta", "Corbilta", "Corbilta", "Corbilta", "Corbilta", "Corbilta", "Corbilta", "Corbilta", "Corbilta", "Corbilta", "Corbilta", "Corbilta", "Corbilta", "Corbilta", "Corbilta", "Corbilta", "Corbilta", "Corbilta", "Corbilta", "Corbilta", "Corbilta", "Corbilta", "Corbilta", "Corbilta", "Corbilta", "Corbilta", "Corbilta", "Corbilta", "Corbilta", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Stalevo", "Levodopa/carbidopa/entacapone Orion", "Levodopa/carbidopa/entacapone Orion", "Levodopa/carbidopa/entacapone Orion", "Levodopa/carbidopa/entacapone Orion", "Levodopa/carbidopa/entacapone Orion", "Levodopa/carbidopa/entacapone Orion", "Levodopa/carbidopa/entacapone Orion", "Levodopa/carbidopa/entacapone Orion", "Levodopa/carbidopa/entacapone Orion", "Levodopa/carbidopa/entacapone Orion", "Levodopa/carbidopa/entacapone Orion", "Levodopa/carbidopa/entacapone Orion", "Levodopa/carbidopa/entacapone Orion", "Levodopa/carbidopa/entacapone Orion", "Levodopa/carbidopa/entacapone Orion", "Levodopa/carbidopa/entacapone Orion", "Levodopa/carbidopa/entacapone Orion", "Levodopa/carbidopa/entacapone Orion", "Levodopa/carbidopa/entacapone Orion", "Levodopa/carbidopa/entacapone Orion", "Levodopa/carbidopa/entacapone Orion", "Levodopa/carbidopa/entacapone Orion", "Levodopa/carbidopa/entacapone Orion", "Levodopa/carbidopa/entacapone Orion", "Levodopa/carbidopa/entacapone Orion", "Levodopa/carbidopa/entacapone Orion", "Levodopa/carbidopa/entacapone Orion", "Levodopa/carbidopa/entacapone Orion", "Levodopa/carbidopa/entacapone Orion", "Levodopa/carbidopa/entacapone Orion", "Levodopa/carbidopa/entacapone Orion", "Levodopa/carbidopa/entacapone Orion", "Levodopa/carbidopa/entacapone Orion", "Levodopa/carbidopa/entacapone Orion", "Levodopa/carbidopa/entacapone Orion", "Levodopa/carbidopa/entacapone Orion", "Levodopa/carbidopa/entacapone Orion", "Levodopa/carbidopa/entacapone Orion" ]	[ "P21964" ]	[ "P10635", "P21964", "O60656" ]	[]	[]
DB00495	Zidovudine	A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription. It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves certain other clinical abnormalities associated with AIDS. Its principal toxic effect is dose-dependent suppression of bone marrow, resulting in anemia and leukopenia. [PubChem]	solid	Used in combination with other antiretroviral agents for the treatment of human immunovirus (HIV) infections.	Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI) with activity against Human Immunodeficiency Virus Type 1 (HIV-1). Zidovudine is phosphorylated to active metabolites that compete for incorporation into viral DNA. They inhibit the HIV reverse transcriptase enzyme competitively and act as a chain terminator of DNA synthesis. The lack of a 3'-OH group in the incorporated nucleoside analogue prevents the formation of the 5' to 3' phosphodiester linkage essential for DNA chain elongation, and therefore, the viral DNA growth is terminated.	Zidovudine, a structural analog of thymidine, is a prodrug that must be phosphorylated to its active 5′-triphosphate metabolite, zidovudine triphosphate (ZDV-TP). It inhibits the activity of HIV-1 reverse transcriptase (RT) via DNA chain termination after incorporation of the nucleotide analogue. It competes with the natural substrate dGTP and incorporates itself into viral DNA. It is also a weak inhibitor of cellular DNA polymerase α and γ.	Rapid and nearly complete absorption from the gastrointestinal tract following oral administration; however, because of first-pass metabolism, systemic bioavailability of zidovudine capsules and solution is approximately 65% (range, 52 to 75%). Bioavailability in neonates up to 14 days of age is approximately 89%, and it decreases to approximately 61% and 65% in neonates over 14 days of age and children 3 months to 12 years, respectively. Administration with a high-fat meal may decrease the rate and extent of absorption.	Hepatic. Metabolized by glucuronide conjugation to major, inactive metabolite, 3′-azido-3′-deoxy-5′- O-beta-D-glucopyranuronosylthymidine (GZDV). UGT2B7 is the primary UGT isoform that is responsible for glucuronidation. Compared to zidovudine, GZDV's area under the curve is approximately 3-fold greater. The cytochrome P450 isozymes are responsible for the reduction of the azido moiety to form 3'-amino-3'- deoxythymidine (AMT).	Symptoms of overdose include fatigue, headache, nausea, and vomiting. LD<sub>50</sub> is 3084 mg/kg (orally in mice).	Elimination half life, HIV-infected patients, IV administration = 1.1 hours (range of 0.5 - 2.9 hours)	30-38%	As in adult patients, the major route of elimination was by metabolism to GZDV. After intravenous dosing, about 29% of the dose was excreted in the urine unchanged and about 45% of the dose was excreted as GZDV.	Apparent volume of distribution, HIV-infected patients, IV administration = 1.6 ± 0.6 L/kg	* 0.65 +/- 0.29 L/hr/kg [HIV-infected, Birth to 14 Days of Age] * 1.14 +/- 0.24 L/hr/kg [HIV-infected, 14 Days to 3 Months of Age] * 1.85 +/- 0.47 L/hr/kg [HIV-infected, 3 Months to 12 Years of Age]. The transporters, ABCB1, ABCC4, ABCC5, and ABCG2 are involved with the clearance of zidovudine.	Organic compounds	Nucleosides, nucleotides, and analogues	Pyrimidine nucleosides	Pyrimidine 2',3'-dideoxyribonucleosides	[ "approved" ]	[ "J05AR", "J05A", "J05", "J", "J05AF", "J05A", "J05", "J", "J05AR", "J05A", "J05", "J", "J05AR", "J05A", "J05", "J" ]	[ "Human Immunodeficiency Virus" ]	[ { "cost": "1.61", "description": "Retrovir iv infusion vial", "unit": "ml" }, { "cost": "3.09", "description": "Retrovir 100 mg capsule", "unit": "capsule" }, { "cost": "6.17", "description": "Zidovudine 300 mg tablet", "unit": "tablet" }, { "cost": "9.1", "description": "Retrovir 300 mg tablet", "unit": "tablet" }, { "cost": "74.11", "description": "Retrovir 50 mg/5ml Syrup 240ml Bottle", "unit": "bottle" } ]	[ { "approved": "2004-07-20", "country": "Canada", "expires": "2016-03-28", "number": "2216634" }, { "approved": "2002-09-24", "country": "Canada", "expires": "2012-03-05", "number": "2105487" }, { "approved": "1999-05-18", "country": "United States", "expires": "2016-11-18", "number": "5905082" }, { "approved": "2001-09-25", "country": "United States", "expires": "2018-11-14", "number": "6294540" }, { "approved": "2002-07-09", "country": "United States", "expires": "2016-09-28", "number": "6417191" } ]	Azidothymidine \| AZT \| ZDV \| Zidovudina \| Zidovudine \| Zidovudinum \| 2.7.10.1 \| CD135 \| Fetal liver kinase-2 \| FL cytokine receptor \| FLK-2 \| FLK2 \| FLT-3 \| Fms-like tyrosine kinase 3 \| Stem cell tyrosine kinase 1 \| STK-1 \| STK1 \| Pr160Gag-Pol \| 2.7.7.49 \| EST2 \| HEST2 \| TCS1 \| Telomerase catalytic subunit \| Telomerase-associated protein 2 \| TP2 \| TRT \| 1,4-cineole 2-exo-monooxygenase \| 1.14.14.- \| Coumarin 7-hydroxylase \| CYP2A3 \| CYPIIA6 \| Cytochrome P450 IIA3 \| Cytochrome P450(I) \| (R)-limonene 6-monooxygenase \| (S)-limonene 6-monooxygenase \| (S)-limonene 7-monooxygenase \| 1.14.14.1 \| Cholesterol 25-hydroxylase \| CYP2C10 \| CYPIIC9 \| Cytochrome P-450MP \| Cytochrome P450 MP-4 \| Cytochrome P450 MP-8 \| Cytochrome P450 PB-1 \| S-mephenytoin 4-hydroxylase \| 1,4-cineole 2-exo-monooxygenase \| 1,8-cineole 2-exo-monooxygenase \| 1.14.14.1 \| Albendazole monooxygenase (sulfoxide-forming) \| Albendazole sulfoxidase \| Cholesterol 25-hydroxylase \| CYP3A3 \| CYPIIIA3 \| CYPIIIA4 \| Cytochrome P450 3A3 \| Cytochrome P450 HLp \| Cytochrome P450 NF-25 \| Cytochrome P450-PCN1 \| Nifedipine oxidase \| Quinine 3-monooxygenase \| 2.7.1.21 \| 2.4.1.17 \| 3,4-catechol estrogen-specific UDPGT \| UDP-glucuronosyltransferase 2B9 \| UDPGT 2B7 \| UDPGT 2B9 \| UDPGTh-2 \| UGT2B7 \| UGTB2B9 \| 2.4.1.17 \| Bilirubin-specific UDPGT isozyme 1 \| GNT1 \| hUG-BR1 \| UDP-glucuronosyltransferase 1-1 \| UDP-glucuronosyltransferase 1A isoform 1 \| UDPGT 1-1 \| UGT1 \| UGT1-01 \| UGT1.1 \| UGT1*1 \| UGT1A1 \| hOCT2 \| OCT2 \| Organic cation transporter 2 \| hOAT1 \| hPAHT \| hROAT1 \| OAT1 \| Organic anion transporter 1 \| PAH transporter \| PAHT \| Renal organic anion transporter 1 \| hOAT2 \| NLT \| Novel liver transporter \| OAT2 \| Organic anion transporter 2 \| hOAT3 \| OAT3 \| Organic anion/dicarboxylate exchanger \| Solute carrier family 22 member 8 \| OAT4 \| Organic anion transporter 4 \| Organic anion:dicarboxylate exchanger OAT4 \| CNT 1 \| CNT1 \| Concentrative nucleoside transporter 1 \| hCNT1 \| Na(+)/nucleoside cotransporter 1 \| Sodium-coupled nucleoside transporter 1 \| Solute carrier family 28 member 1 \| 36 kDa nucleolar protein HNP36 \| Delayed-early response protein 12 \| DER12 \| ENT2 \| Equilibrative NBMPR-insensitive nucleoside transporter \| Equilibrative nitrobenzylmercaptopurine riboside-insensitive nucleoside transporter \| hENT2 \| HNP36 \| Hydrophobic nucleolar protein, 36 kDa \| Nucleoside transporter, ei-type \| Solute carrier family 29 member 2 \| ATP-binding cassette sub-family B member 1 \| MDR1 \| Multidrug resistance protein 1 \| P-glycoprotein 1 \| PGY1 \| Phospholipid transporter ABCB1 \| 7.6.2.- \| 7.6.2.2 \| 7.6.2.3 \| MOAT-B \| MOATB \| MRP/cMOAT-related ABC transporter \| MRP4 \| Multi-specific organic anion transporter B \| Multidrug resistance-associated protein 4 \| 7.6.2.- \| 7.6.2.2 \| MOAT-C \| MRP5 \| Multi-specific organic anion transporter C \| Multidrug resistance-associated protein 5 \| pABC11 \| SMRP \| 7.6.2.2 \| ABCP \| ATP-binding cassette sub-family G member 2 \| BCRP \| BCRP1 \| Breast cancer resistance protein \| CDw338 \| Mitoxantrone resistance-associated protein \| MXR \| Placenta-specific ATP-binding cassette transporter \| Urate exporter	[ "Abacavir Sulfate, Lamivudine and Zidovudine", "Abacavir, Lamivudine and Zidovudine", "Apo-abacavir-lamivudine-zidovudine", "Apo-lamivudine-zidovudine", "Apo-zidovudine", "Apo-zidovudine-lamivudine-nevirapine", "Auro-lamivudine/zidovudine", "Combivir", "Combivir", "Combivir", "Combivir", "Combivir", "Combivir", "Combivir", "Combivir", "Combivir", "Combivir", "Combivir", "Combivir", "Combivir", "Combivir", "Jamp Lamivudine / Zidovudine", "Lamivudine and Zidovudine", "Lamivudine and Zidovudine", "Lamivudine and Zidovudine", "Lamivudine and Zidovudine", "Lamivudine and Zidovudine", "Lamivudine and Zidovudine", "Lamivudine and Zidovudine", "Lamivudine and Zidovudine", "Lamivudine and Zidovudine", "LAMIVUDINE and ZIDOVUDINE", "Lamivudine and Zidovudine", "Lamivudine and Zidovudine", "Lamivudine and Zidovudine", "Lamivudine and Zidovudine", "Lamivudine and Zidovudine", "Lamivudine and Zidovudine", "Lamivudine and Zidovudine", "Lamivudine and Zidovudine", "Lamivudine and Zidovudine", "Lamivudine and Zidovudine", "Lamivudine and Zidovudine", "LAMIVUDINE and ZIDOVUDINE", "LAMIVUDINE and ZIDOVUDINE", "Lamivudine and Zidovudine", "LAMIVUDINE and ZIDOVUDINE", "Lamivudine and Zidovudine", "LAMIVUDINE and ZIDOVUDINE", "Lamivudine and Zidovudine", "Lamivudine and Zidovudine", "LAMIVUDINE and ZIDOVUDINE", "Lamivudine and Zidovudine", "Lamivudine and Zidovudine", "Lamivudine and Zidovudine", "Lamivudine and Zidovudine", "Lamivudine and Zidovudine", "LAMIVUDINE and ZIDOVUDINE", "Lamivudine and Zidovudine", "Lamivudine Zidovudine", "Lamivudine, Nevirapine, and Zidovudine", "Lamivudine/zidovudine Teva", "Lamivudine/zidovudine Teva", "Novo-azt Cap 100mg", "Retrovir", "Retrovir", "Retrovir", "Retrovir", "Retrovir", "Retrovir", "Retrovir", "Retrovir", "Retrovir", "Retrovir (azt)", "Retrovir (azt)", "Retrovir (azt)", "Retrovir (azt) 300mg", "Teva-lamivudine/zidovudine", "Trizivir", "Trizivir", "Trizivir", "Trizivir", "Trizivir", "Trizivir", "Trizivir", "Zidovudine", "Zidovudine", "Zidovudine", "Zidovudine", "Zidovudine", "Zidovudine", "Zidovudine", "Zidovudine", "Zidovudine", "Zidovudine", "Zidovudine", "Zidovudine", "Zidovudine", "Zidovudine", "Zidovudine", "Zidovudine", "Zidovudine", "Zidovudine", "Zidovudine", "Zidovudine", "Zidovudine", "Zidovudine", "Zidovudine", "Zidovudine", "Zidovudine", "Zidovudine", "Zidovudine", "Zidovudine", "Zidovudine", "Zidovudine", "Zidovudine", "Zidovudine", "Zidovudine", "Zidovudine", "Zidovudine", "Zidovudine Oral Solution USP" ]	[]	[ "Combivir", "Combivir", "Trizivir", "Combivir", "Combivir", "Combivir", "Lamivudine and Zidovudine", "Lamivudine and Zidovudine", "Combivir", "Lamivudine and Zidovudine", "Combivir", "Trizivir", "Lamivudine and Zidovudine", "Abacavir Sulfate, Lamivudine and Zidovudine", "Combivir", "Lamivudine Zidovudine", "Combivir", "Lamivudine and Zidovudine", "Lamivudine and Zidovudine", "Lamivudine and Zidovudine", "Lamivudine and Zidovudine", "Lamivudine and Zidovudine", "LAMIVUDINE and ZIDOVUDINE", "Lamivudine and Zidovudine", "Lamivudine and Zidovudine", "Lamivudine and Zidovudine", "Lamivudine and Zidovudine", "Lamivudine and Zidovudine", "Combivir", "Lamivudine and Zidovudine", "Abacavir, Lamivudine and Zidovudine", "Lamivudine and Zidovudine", "Lamivudine and Zidovudine", "Lamivudine and Zidovudine", "Lamivudine and Zidovudine", "Lamivudine and Zidovudine", "LAMIVUDINE and ZIDOVUDINE", "Lamivudine, Nevirapine, and Zidovudine", "LAMIVUDINE and ZIDOVUDINE", "Lamivudine and Zidovudine", "LAMIVUDINE and ZIDOVUDINE", "Lamivudine and Zidovudine", "LAMIVUDINE and ZIDOVUDINE", "Lamivudine and Zidovudine", "Lamivudine and Zidovudine", "LAMIVUDINE and ZIDOVUDINE", "Lamivudine and Zidovudine", "Lamivudine and Zidovudine", "Lamivudine and Zidovudine", "Lamivudine and Zidovudine", "Combivir", "Lamivudine and Zidovudine", "LAMIVUDINE and ZIDOVUDINE", "Trizivir", "Lamivudine and Zidovudine", "Combivir", "Teva-lamivudine/zidovudine", "Apo-lamivudine-zidovudine", "Auro-lamivudine/zidovudine", "Apo-zidovudine-lamivudine-nevirapine", "Jamp Lamivudine / Zidovudine", "Trizivir", "Apo-abacavir-lamivudine-zidovudine", "Lamivudine/zidovudine Teva", "Lamivudine/zidovudine Teva", "Trizivir", "Trizivir", "Trizivir", "Combivir", "Combivir" ]	[ "P36888", "P03366", "O14746" ]	[ "P11509", "P11712", "P08684", "P04183", "P16662", "P22309" ]	[ "P02768" ]	[ "O15244", "Q4U2R8", "Q9Y694", "Q8TCC7", "Q9NSA0", "O00337", "Q14542", "P08183", "O15439", "O15440", "Q9UNQ0" ]
DB00496	Darifenacin	Darifenacin (Enablex®, Novartis) is a medication used to treat urinary incontinence. Darifenacin blocks M3 muscarinic acetylcholine receptors, which mediate bladder muscle contractions. This block reduces the urgency to urinate and so it should not be used in people with urinary retention. It is unknown if M3 receptor selectivity is clinically advantageous in overactive bladder syndrome treatments.	solid	For the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency and frequency.	Darifenacin is a competitive muscarinic receptor antagonist. <i>In vitro</i> studies using human recombinant muscarinic receptor subtypes show that darifenacin has greater affinity for the M3 receptor than for the other known muscarinic receptors (9 and 12-fold greater affinity for M3 compared to M1 and M5, respectively, and 59-fold greater affinity for M3 compared to both M2 and M4). Muscarinic receptors play an important role in several major cholinergically mediated functions, including contractions of the urinary bladder smooth muscle and stimulation of salivary secretion. Adverse drug effects such as dry mouth, constipation and abnormal vision may be mediated through effects on M3 receptors in these organs.	Darifenacin selectively antagonizes the muscarinic M3 receptor. M3 receptors are involved in contraction of human bladder and gastrointestinal smooth muscle, saliva production, and iris sphincter function.	The mean oral bioavailability at steady state is estimated to be 15% and 19% for 7.5 mg and 15 mg tablets, respectively.	Hepatic. Primarily mediated by the cytochrome P450 enzymes CYP2D6 and CYP3A4.	Overdosage can potentially result in severe central anticholinergic effects.	The elimination half-life of darifenacin following chronic dosing is approximately 13-19 hours.	Darifenacin is approximately 98% bound to plasma proteins (primarily to alpha-1-acid-glycoprotein).	null	* 163 L	* 40 L/h [extensive metabolizers] * 32 L/h [poor metabolizers]	Organic compounds	Benzenoids	Benzene and substituted derivatives	Diphenylmethanes	[ "approved", "investigational" ]	[ "G04BD", "G04B", "G04", "G" ]	[ "Humans and other mammals" ]	[ { "cost": "5.02", "description": "Enablex 15 mg tablet", "unit": "tablet" }, { "cost": "5.02", "description": "Enablex 7.5 mg tablet", "unit": "tablet" }, { "cost": "5.22", "description": "Enablex 15 mg 24 Hour tablet", "unit": "tablet" }, { "cost": "5.22", "description": "Enablex 7.5 mg 24 Hour tablet", "unit": "tablet" } ]	[ { "approved": "1992-03-17", "country": "United States", "expires": "2015-03-13", "number": "5096890" }, { "approved": "2010-07-06", "country": "Canada", "expires": "2022-03-05", "number": "2469702" }, { "approved": "2003-06-24", "country": "Canada", "expires": "2016-08-21", "number": "2230314" }, { "approved": "2000-08-22", "country": "United States", "expires": "2016-08-21", "number": "6106864" } ]	(S)-1-(2-(2,3-dihydro-5-benzofuranyl)ethyl)-α,α-diphenyl-3-pyrrolidineacetamide \| Darifenacin \| Darifenacina \| Darifénacine \| Darifenacinum \| 1,4-cineole 2-exo-monooxygenase \| 1,8-cineole 2-exo-monooxygenase \| 1.14.14.1 \| Albendazole monooxygenase (sulfoxide-forming) \| Albendazole sulfoxidase \| Cholesterol 25-hydroxylase \| CYP3A3 \| CYPIIIA3 \| CYPIIIA4 \| Cytochrome P450 3A3 \| Cytochrome P450 HLp \| Cytochrome P450 NF-25 \| Cytochrome P450-PCN1 \| Nifedipine oxidase \| Quinine 3-monooxygenase \| 1.14.14.- \| Cholesterol 25-hydroxylase \| CYP2DL1 \| CYPIID6 \| Cytochrome P450-DB1 \| Debrisoquine 4-hydroxylase	[ "Apo-darifenacin", "Apo-darifenacin", "Darifenacin", "Darifenacin", "Darifenacin", "Darifenacin", "Darifenacin", "Darifenacin", "Darifenacin", "Darifenacin", "Darifenacin", "Darifenacin", "Darifenacin", "Darifenacin", "Darifenacin", "Darifenacin", "Darifenacin", "Darifenacin", "Darifenacin", "Darifenacin", "Darifenacin", "Darifenacin", "Darifenacin", "Darifenacin", "Darifenacin 15 mg", "Darifenacin 15 mg", "Darifenacin 7.5 mg", "Darifenacin 7.5 mg", "Darifenacin Hydrobromide Extended-Release", "Darifenacin Hydrobromide Extended-Release", "Darifenacin Hydrobromide Extended-Release", "Darifenacin Hydrobromide Extended-Release", "Darifenacin Hydrobromide Extended-Release", "Darifenacin Hydrobromide Extended-Release", "Emselex", "Emselex", "Emselex", "Emselex", "Emselex", "Emselex", "Emselex", "Emselex", "Emselex", "Emselex", "Emselex", "Emselex", "Emselex", "Emselex", "Emselex", "Emselex", "Emselex", "Emselex", "Emselex", "Emselex", "Emselex", "Emselex", "Emselex", "Emselex", "Emselex", "Emselex", "Emselex", "Emselex", "Enablex", "Enablex", "Enablex", "Enablex", "Enablex", "Enablex", "Enablex", "Enablex", "Enablex", "Jamp Darifenacin", "Jamp Darifenacin" ]	[ "Emselex", "Xelena" ]	[]	[ "P20309", "P11229", "P08172", "P08173", "P08912" ]	[ "P08684", "P10635" ]	[]	[]
DB00497	Oxycodone	Oxycodone is a semisynthetic opioid analgesic derived from thebaine in Germany in 1917.[A178696] It is currently indicated as an immediate release product for moderate to severe pain and as an extended release product for chronic moderate to severe pain requiring continuous opioid analgesics for an extended period.[Label] The first oxycodone containing product, Percodan, was approved by the FDA on April 12, 1950.[L6460]	solid	Oxycodone is indicated for the treatment of moderate to severe pain.[Label] There is also an extended release formulation indicated for chronic moderate to severe pain requiring continuous opioid analgesics for an extended period.[Label]	Oxycodone acts directly on a number of tissues not related to its analgesic effect. These tissues include the respiratory centre in the brain stem, the cough centre in the medulla, muscles of the pupils, gastrointestinal tract, cardiovascular system, endocrine system, and immune system.[Label] Oxycodone's effect on the respiratory centre is dose dependant respiratory depression.[Label] The action on the cough centre is suppression of the cough reflex.[Label] Pupils become miopic or decrease in size, peristalsis of the gastrointestinal tract slows, and muscle tone in the colon may increase causing constipation.[Label] In the cardiovascular system histamine may be released leading to pruritis, red eyes, flushing, sweating, and decreased blood pressure.[Label] Endocrine effects may include increased prolactin, decreased cortisol, and decreased testosterone.[Label] It is not yet known if the effects of opioids on the immune system are clinically significant.[Label]	The full mechanism of oxycodone is not known.[Label] Under conditions of inflammation or hyperalgesia, opioid receptors in the heart, lungs, liver, gastrointestinal tract, and reproductive system are upregulated and transported to nerve terminals.[A178696] Oxycodone and its active metabolites, noroxycodone, oxymorphone, and noroxymorphone are opioid agonists.[A178639] These compounds passively diffuse across the blood brain barrier or may be actively transported across by an unknown mechanism.[A178696] Oxycodone and its active metabolites can selectively bind to the mu opioid receptor, but also the kappa and delta opioid receptors in the central nervous system and periphery, and induce a G protein coupled receptor signalling pathway.[A178696] Activation of mu opioid receptors inhibits N-type voltage operated calcium channels, inhibiting responses to pain.[A178735]	Oxycodone has an oral bioavailability of 60% to 87% that is unaffected by food.[Label] The area under the curve is 135ng/mL\*hr, maximum plasma concentration is 11.5ng/mL, and time to maximum concentration is 5.11hr in patients given a 10mg oral immediate release dose of oxycodone.[Label]	Oxycodone's hepatic metabolism is extensive and completed by 4 main reactions. CYP3A4 and 3A5 perform N-demethylation, CYP2D6 performs O-demethylation, unknown enzymes perform 6-keto-reduction, and unknown enzymes perform conjugation.[A178639] Oxycodone is metabolized by CYP3A4 and CYP3A5 to noroxycodone and then by CYP2D6 to noroxymorphone.[A178639] Noroxycodone and noroxymorphone are the primary circulating metabolites.[Label] Noroxycodone can also be 6-keto-reduced to alpha or beta noroxycodol.[A178639] Oxycodone can be metabolized by CYP2D6 to oxymorphone and then by CYP3A4 to noroxymorphone.[A178639] Oxymorphone can also be 6-keto-reduced to alpha or beta oxymorphol.[A178639] Oxycodone can also be 6-keto-reduced to alpha and beta oxycodol.[A178639] The active metabolites noroxycodone, oxymorphone, and noroxymorphone can all be conjugated before elimination.[A178639]	Patients experiencing an overdose may present with respiratory depression, sleepiness, stupor, coma, skeletal muscle flaccidity, cold sweat, constricted pupils, bradycardia, hypotension, partial or complete airway obstruction, atypical snoring, and death.[Label] Overdose should be treated by maintaining airway, ventilation, and oxygenation.[Label] Oxygen and vasopressor treatment may be necessary to treat circulatory shock and pulmonary edema and defibrillation may be required for cardiac arrest of arrhythmia.[Label] [Naloxone], [nalmefene], or [naltrexone] may be used to counteract the effects of opioids but patients should be monitored in case further doses are required.[Label] The intraperitoneal LD50 in mice is 320mg/kg, the oral LD50 is 426mg/kg.[MSDS] The oral lowest dose causing toxic effects in humans is 0.14mg/kg and subcutaneously in rats it is 1.53mg/kg.[MSDS] Oxycodone is pregnancy category B according to the FDA.[Label] There is a paucity of data regarding oxycodone use in pregnancy, though animal studies show no teratogenic effects.[Label] Rats given oxycodone during lactation showed smaller offspring, though after lactation, they recovered to normal size.[Label] Oxycodone is excreted in breast milk and so patients should not breastfeed while taking oxycodone due to risk of sedation and respiratory depression in infants.[Label] No studies on the carcinogenicity of oxycodone have been performed.[Label] Oxycodone was genotoxic at 50mcg/mL with metabolic activation and at 400mcg/mL without.[Label] It was also clastogenic with metabolic activation at ≥1250mcg/mL.[Label] Oxycodone was not found to be genotoxic in other tests.[Label] Oxycodone does not affect reproduction and fertility in rats at doses of up to 8mg/kg/day.[Label]	The apparent elimination half life of oxycodone is 3.2 hours for immediate release formulations and 4.5 hours for extended release formulations.[Label] Noroxycodone has a half life of 5.8 hours, oxymorphone has a half life of 8.8 hours, noroxymorphone has a half life of 9 hours.[A178639]	45%.[Label] Oxycodone is primarily bound to serum albumin and to a lesser degree alpha1-acid glycoprotein.[A18203]	Oxycodone and its metabolites are eliminated in the urine.[Label] Unbound noroxycodone makes up 23% of the dose recovered in urine and oxymorphone makes up <1%.[Label] Conjugated oxymorphone makes up 10% of the recovered dose.[Label] Free and conjugated oxycodone makes up 8.9% of the recovered dose, noroxymorphone makes up 14%, and reduced metabolites make up 18%.[Label]	2.6L/kg.[Label]	Total plasma clearance is 1.4L/min in adults.[Label]	Organic compounds	Benzenoids	Phenanthrenes and derivatives	null	[ "approved", "illicit", "investigational" ]	[ "N02AA", "N02A", "N02", "N", "N02AA", "N02A", "N02", "N", "N02AA", "N02A", "N02", "N", "N02AJ", "N02A", "N02", "N", "N02AJ", "N02A", "N02", "N", "N02AJ", "N02A", "N02", "N" ]	[ "Humans and other mammals" ]	[ { "cost": "1.1", "description": "Oxycodone hcl 20 mg tablet", "unit": "tablet" }, { "cost": "1.18", "description": "Endodan 4.83-325 mg tablet", "unit": "tablet" }, { "cost": "1.19", "description": "Oxycontin 15 mg Sustained-Release Tablet", "unit": "tablet" }, { "cost": "1.41", "description": "Oxycodone hcl 30 mg tablet", "unit": "tablet" }, { "cost": "1.44", "description": "Dazidox 20 mg tablet", "unit": "tablet" }, { "cost": "1.46", "description": "Oxycontin 20 mg Sustained-Release Tablet", "unit": "tablet" }, { "cost": "1.62", "description": "Percodan tablet", "unit": "tablet" }, { "cost": "1.82", "description": "Endocet 5-325 tablet", "unit": "tablet" }, { "cost": "1.87", "description": "Endocet 10-325 mg tablet", "unit": "tablet" }, { "cost": "1.96", "description": "Oxycontin 30 mg Sustained-Release Tablet", "unit": "tablet" }, { "cost": "1.98", "description": "Percodan 4.5-0.38-325 mg tablet", "unit": "tablet" }, { "cost": "2.05", "description": "Oxycodone-apap 2.5-325 mg tablet", "unit": "tablet" }, { "cost": "2.22", "description": "Endocet 7.5-500 mg tablet", "unit": "tablet" }, { "cost": "2.3", "description": "Roxicodone intensol 20 mg/ml", "unit": "ml" }, { "cost": "2.33", "description": "Supeudol 10 mg Suppository", "unit": "suppository" }, { "cost": "2.53", "description": "OxyCONTIN 10 mg 12 Hour tablet", "unit": "tablet" }, { "cost": "2.54", "description": "Endocet 7.5-325 mg tablet", "unit": "tablet" }, { "cost": "2.54", "description": "Oxycontin 40 mg Sustained-Release Tablet", "unit": "tablet" }, { "cost": "2.7", "description": "Endocet 10-650 mg tablet", "unit": "tablet" }, { "cost": "2.82", "description": "Oxycodone hcl 10 mg tablet", "unit": "tablet" }, { "cost": "2.83", "description": "Roxicodone 15 mg tablet", "unit": "tablet" }, { "cost": "2.95", "description": "Supeudol 20 mg Suppository", "unit": "suppository" }, { "cost": "3.22", "description": "Oxycontin 15 mg tablet", "unit": "tablet" }, { "cost": "3.55", "description": "Oxycontin 60 mg Sustained-Release Tablet", "unit": "tablet" }, { "cost": "4.27", "description": "OxyCONTIN 20 mg 12 Hour tablet", "unit": "tablet" }, { "cost": "4.38", "description": "OxyCODONE HCl 40 mg 12 Hour tablet", "unit": "tablet" }, { "cost": "4.69", "description": "Oxycontin 80 mg Sustained-Release Tablet", "unit": "tablet" }, { "cost": "5.19", "description": "Roxicodone 30 mg tablet", "unit": "tablet" }, { "cost": "5.8", "description": "OxyCONTIN 30 mg 12 Hour tablet", "unit": "tablet" }, { "cost": "6.59", "description": "Oxycontin 30 mg tablet", "unit": "tablet" }, { "cost": "6.89", "description": "Oxycontin 10 mg tablet", "unit": "tablet" }, { "cost": "7.68", "description": "OxyCONTIN 40 mg 12 Hour tablet", "unit": "tablet" }, { "cost": "8.33", "description": "OxyCODONE HCl 80 mg 12 Hour tablet", "unit": "tablet" }, { "cost": "9.45", "description": "Oxycontin 40 mg tablet", "unit": "tablet" }, { "cost": "10.57", "description": "OxyCONTIN 60 mg 12 Hour tablet", "unit": "tablet" }, { "cost": "11.53", "description": "Oxycontin 80 mg tablet", "unit": "tablet" }, { "cost": "11.87", "description": "Oxycontin 20 mg tablet", "unit": "tablet" }, { "cost": "14.36", "description": "OxyCONTIN 80 mg 12 Hour tablet", "unit": "tablet" }, { "cost": "17.08", "description": "Oxycontin 60 mg tablet", "unit": "tablet" }, { "cost": "33.99", "description": "OxyCODONE HCl 20 mg/ml Concentrate 30ml Bottle", "unit": "bottle" }, { "cost": "46.99", "description": "Roxicodone 20 mg/ml Concentrate 30ml Bottle", "unit": "bottle" }, { "cost": "53.0", "description": "Roxicodone 5 mg/5ml Solution 500ml Bottle", "unit": "bottle" }, { "cost": "53.64", "description": "Oxycodone hcl powder", "unit": "g" }, { "cost": "0.14", "description": "Pms-Oxycodone 5 mg Tablet", "unit": "tablet" }, { "cost": "0.14", "description": "Supeudol 5 mg Tablet", "unit": "tablet" }, { "cost": "0.24", "description": "Pms-Oxycodone 10 mg Tablet", "unit": "tablet" }, { "cost": "0.24", "description": "Supeudol 10 mg Tablet", "unit": "tablet" }, { "cost": "0.36", "description": "Oxycodone 5 mg tablet", "unit": "tablet" }, { "cost": "0.42", "description": "Pms-Oxycodone 20 mg Tablet", "unit": "tablet" }, { "cost": "0.42", "description": "Supeudol 20 mg Tablet", "unit": "tablet" }, { "cost": "0.43", "description": "Oxy-Ir 10 mg Tablet", "unit": "tablet" }, { "cost": "0.52", "description": "Oxyir 5 mg capsule", "unit": "capsule" }, { "cost": "0.56", "description": "Roxicodone 5 mg tablet", "unit": "tablet" }, { "cost": "0.6", "description": "Endocet 5-325 mg tablet", "unit": "tablet" }, { "cost": "0.7", "description": "Oxycontin 5 mg Sustained-Release Tablet", "unit": "tablet" }, { "cost": "0.71", "description": "OxyCODONE HCl 5 mg capsule", "unit": "capsule" }, { "cost": "0.74", "description": "Oxy-Ir 20 mg Tablet", "unit": "tablet" }, { "cost": "0.75", "description": "Dazidox 10 mg tablet", "unit": "tablet" }, { "cost": "0.81", "description": "Oxycodone hcl 5 mg tablet", "unit": "tablet" }, { "cost": "0.9", "description": "Oxycodone hcl 15 mg tablet", "unit": "tablet" }, { "cost": "0.98", "description": "Oxycontin 10 mg Sustained-Release Tablet", "unit": "tablet" } ]	[ { "approved": "1996-04-16", "country": "United States", "expires": "2013-04-16", "number": "5508042" }, { "approved": "1999-08-17", "country": "Canada", "expires": "2012-11-25", "number": "2098738" }, { "approved": "2015-12-08", "country": "United States", "expires": "2022-05-10", "number": "9205082" }, { "approved": "2002-12-03", "country": "United States", "expires": "2020-06-20", "number": "6488962" }, { "approved": "2012-11-13", "country": "United States", "expires": "2023-11-20", "number": "8309060" }, { "approved": "2014-08-19", "country": "United States", "expires": "2027-08-24", "number": "8808741" }, { "approved": "2015-07-07", "country": "United States", "expires": "2025-03-30", "number": "9073933" }, { "approved": "2015-06-23", "country": "United States", "expires": "2022-08-06", "number": "9060976" }, { "approved": "2002-12-03", "country": "United States", "expires": "2017-06-24", "number": "6488963" }, { "approved": "2010-03-09", "country": "United States", "expires": "2025-03-30", "number": "7674800" }, { "approved": "2010-03-23", "country": "United States", "expires": "2025-03-30", "number": "7683072" }, { "approved": "2012-12-25", "country": "United States", "expires": "2022-08-06", "number": "8337888" }, { "approved": "2010-08-17", "country": "United States", "expires": "2025-04-19", "number": "7776314" }, { "approved": "2014-11-25", "country": "United States", "expires": "2027-08-24", "number": "8894988" }, { "approved": "2010-03-09", "country": "United States", "expires": "2025-03-30", "number": "7674799" }, { "approved": "2012-02-14", "country": "United States", "expires": "2024-10-10", "number": "8114383" }, { "approved": "2014-11-25", "country": "United States", "expires": "2030-03-29", "number": "8894987" }, { "approved": "2014-04-01", "country": "United States", "expires": "2025-07-03", "number": "8685443" }, { "approved": "2010-10-19", "country": "United States", "expires": "2027-12-12", "number": "7815934" }, { "approved": "2015-10-27", "country": "United States", "expires": "2022-05-10", "number": "9168252" }, { "approved": "2015-10-20", "country": "United States", "expires": "2022-05-10", "number": "9161937" }, { "approved": "2015-03-03", "country": "United States", "expires": "2022-05-10", "number": "8969369" }, { "approved": "2015-07-21", "country": "United States", "expires": "2022-05-10", "number": "9084729" }, { "approved": "2016-03-15", "country": "United States", "expires": "2022-05-10", "number": "9283216" }, { "approved": "2015-06-16", "country": "United States", "expires": "2022-05-10", "number": "9056051" }, { "approved": "2014-09-30", "country": "United States", "expires": "2023-04-04", "number": "8846090" }, { "approved": "2001-08-21", "country": "United States", "expires": "2018-12-22", "number": "6277384" }, { "approved": "2014-09-02", "country": "United States", "expires": "2018-12-22", "number": "8822487" }, { "approved": "2014-03-18", "country": "United States", "expires": "2018-12-22", "number": "8673355" }, { "approved": "2004-02-24", "country": "United States", "expires": "2018-12-22", "number": "6696066" }, { "approved": "2014-09-30", "country": "United States", "expires": "2023-04-04", "number": "8846091" }, { "approved": "2013-02-12", "country": "United States", "expires": "2029-03-11", "number": "8372432" }, { "approved": "2014-03-11", "country": "United States", "expires": "2029-03-11", "number": "8668929" }, { "approved": "2013-02-19", "country": "United States", "expires": "2029-11-19", "number": "8377453" }, { "approved": "2011-07-12", "country": "United States", "expires": "2027-06-01", "number": "7976870" }, { "approved": "2014-06-03", "country": "United States", "expires": "2032-05-16", "number": "8741885" }, { "approved": "2015-03-31", "country": "United States", "expires": "2032-05-16", "number": "8992975" }, { "approved": "2013-12-03", "country": "United States", "expires": "2030-12-21", "number": "8597681" }, { "approved": "2015-03-17", "country": "United States", "expires": "2030-12-21", "number": "8980319" }, { "approved": "2013-03-12", "country": "United States", "expires": "2029-03-11", "number": "8394408" }, { "approved": "2015-06-09", "country": "United States", "expires": "2032-05-16", "number": "9050335" }, { "approved": "2014-02-25", "country": "United States", "expires": "2032-05-16", "number": "8658631" }, { "approved": "2009-03-31", "country": "United States", "expires": "2023-11-26", "number": "7510726" }, { "approved": "2013-04-02", "country": "United States", "expires": "2023-11-26", "number": "8409616" }, { "approved": "2007-04-10", "country": "United States", "expires": "2025-03-16", "number": "7201920" }, { "approved": "2014-01-28", "country": "United States", "expires": "2023-11-26", "number": "8637540" }, { "approved": "2011-07-19", "country": "United States", "expires": "2023-11-26", "number": "7981439" }, { "approved": "2011-06-07", "country": "United States", "expires": "2028-08-12", "number": "7955619" }, { "approved": "2016-11-15", "country": "United States", "expires": "2027-08-24", "number": 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"2036-09-02", "number": "9968598" }, { "approved": "2018-06-26", "country": "United States", "expires": "2030-12-10", "number": "10004729" }, { "approved": "2018-11-20", "country": "United States", "expires": "2023-11-20", "number": "10130591" }, { "approved": "2019-01-29", "country": "United States", "expires": "2036-09-02", "number": "10188644" }, { "approved": "2019-06-11", "country": "United States", "expires": "2028-08-12", "number": "10314788" }, { "approved": "2019-08-06", "country": "United States", "expires": "2023-06-16", "number": "10369109" }, { "approved": "2019-09-10", "country": "United States", "expires": "2025-03-30", "number": "10407434" }, { "approved": "2020-01-07", "country": "United States", "expires": "2023-07-07", "number": "10525052" }, { "approved": "2020-01-07", "country": "United States", "expires": "2023-07-07", "number": "10525053" }, { "approved": "2020-05-12", "country": "United States", "expires": "2036-09-02", "number": "10646485" }, { "approved": "2020-06-02", "country": "United States", "expires": "2030-12-10", "number": "10668060" }, { "approved": "2020-06-30", "country": "United States", "expires": "2025-03-30", "number": "10696684" }, { "approved": "2020-06-09", "country": "United States", "expires": "2023-11-20", "number": "10675278" }, { "approved": "2007-08-24", "country": "United States", "expires": "2027-08-24", "number": "11304909" }, { "approved": "2007-08-24", "country": "United States", "expires": "2027-08-24", "number": "11304908" }, { "approved": "2007-08-24", "country": "United States", "expires": "2027-08-24", "number": "11964056" }, { "approved": "2005-03-30", "country": "United States", "expires": "2025-03-30", "number": "12060361" } ]	(-)-14-Hydroxydihydrocodeinone \| 4,5-Epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one \| 4,5alpha-Epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one \| 4,5α-Epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one \| Dihydro-14-hydroxycodeinone \| Dihydrohydroxycodeinone \| Dihydroxycodeinone \| Oxicodona \| Oxycodone \| Oxycodonum \| hMOP \| M-OR-1 \| MOP \| MOR-1 \| MOR1 \| Mu opiate receptor \| Mu opioid receptor \| K-OR-1 \| KOR-1 \| OPRK \| D-OR-1 \| DOR-1 \| OPRD \| 1.14.14.- \| Cholesterol 25-hydroxylase \| CYP2DL1 \| CYPIID6 \| Cytochrome P450-DB1 \| Debrisoquine 4-hydroxylase \| 1,4-cineole 2-exo-monooxygenase \| 1,8-cineole 2-exo-monooxygenase \| 1.14.14.1 \| Albendazole monooxygenase (sulfoxide-forming) \| Albendazole sulfoxidase \| Cholesterol 25-hydroxylase \| CYP3A3 \| CYPIIIA3 \| CYPIIIA4 \| Cytochrome P450 3A3 \| Cytochrome P450 HLp \| Cytochrome P450 NF-25 \| Cytochrome P450-PCN1 \| Nifedipine oxidase \| Quinine 3-monooxygenase \| 1.14.14.1 \| CYPIIIA5 \| Cytochrome P450-PCN3 \| AGP 1 \| AGP1 \| OMD 1 \| Orosomucoid-1 \| AGP 2 \| AGP2 \| OMD 2 \| Orosomucoid-2	[ "Act Oxycodone CR", "Act Oxycodone CR", "Act Oxycodone CR", "Act Oxycodone CR", "Act Oxycodone CR", "Apo-oxycodone CR", "Apo-oxycodone CR", "Apo-oxycodone CR", "Apo-oxycodone CR", "Apo-oxycodone CR", "Apo-oxycodone CR", "Apo-oxycodone CR", "Apo-oxycodone CR", "Apo-oxycodone/acet", "Combunox", "Endocet", "Endocet", "Endocet", "Endocet", "Endocet", "Endocet", "Endocet", "Endocet", "Endocet", "Endocet", "Endocet", "Endocet", "Endocet", "Endocet", "Endocet", "Endocet", "Endocet", "Endocet", "Endocet", "Endocet", "Endocet", "Endocet", "Endodan", "Endodan", "Endodan", "Magnacet", "Magnacet", "Magnacet", "Magnacet", "Magnacet", "Magnacet", "Nalocet", "Ntp-oxycodone Acetaminophen", "Nu-oxycodone/acet", "Oxaydo", "Oxaydo", "Oxaydo", "Oxaydo", "Oxecta", "Oxecta", "Oxy.ir", "Oxy.ir", "Oxy.ir", "Oxycodone", "Oxycodone", "Oxycodone", "Oxycodone", "Oxycodone", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and 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Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Aspirin", "Oxycodone and Aspirin", "Oxycodone and Aspirin", "Oxycodone and Aspirin", "Oxycodone and Aspirin", "Oxycodone and Aspirin", "Oxycodone and Aspirin", "Oxycodone Apap", "Oxycodone Apap", "OXYCODONE HCl", "OXYCODONE HCl", "OXYCODONE HCl", "OXYCODONE HCl", "Oxycodone HCl", "Oxycodone HCl", "OXYCODONE HCl", "OXYCODONE HCl", "Oxycodone HCl", "Oxycodone HCl", "Oxycodone HCl", "Oxycodone HCl", "Oxycodone HCl Controlled-Release", "Oxycodone HCl Controlled-Release", "Oxycodone Hydchloride", "Oxycodone Hydchloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone hydrochloride", "Oxycodone hydrochloride", "Oxycodone hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone hydrochloride", "Oxycodone hydrochloride", "Oxycodone hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride", "Oxycodone Hydrochloride and Acetaminophen", "Oxycodone Hydrochloride and Acetaminophen", "Oxycodone Hydrochloride and Acetaminophen", "Oxycodone Hydrochloride and Acetaminophen", "Oxycodone Hydrochloride and Acetaminophen", "Oxycodone Hydrochloride and Acetaminophen", "Oxycodone Hydrochloride and Acetaminophen", "Oxycodone Hydrochloride and Acetaminophen", "Oxycodone Hydrochloride and Acetaminophen", "Oxycodone Hydrochloride and Acetaminophen", "Oxycodone Hydrochloride and Acetaminophen", "Oxycodone Hydrochloride and Acetaminophen", "Oxycodone Hydrochloride and Acetaminophen", "Oxycodone Hydrochloride and Aspirin", "Oxycodone Hydrochloride and Ibuprofen", "Oxycodone Hydrochloride and Ibuprofen", "Oxycodone hydrochloride and Ibuprofen", "Oxycodone hydrochloride and Ibuprofen", "Oxycodone Hydrochloride Controlled-release", "Oxycodone Hydrochloride Controlled-release", "Oxycodone Hydrochloride Controlled-release", "Oxycodone Hydrochloride Controlled-release", "Oxycodone Hydrochloride Immediate-release", "Oxycodone Hydrochloride Oral Solution", "Oxycodone Hydrochloride Oral Solution", "Oxycodone-acet", "Oxycodone/acet", "Oxycodone/acetaminophen", "Oxycodone/apap", "Oxycodone/apap", "Oxycodone/APAP", "Oxycodone/APAP", "Oxycodone/APAP", "Oxycodone/APAP", "Oxycontin", "OxyContin", "OxyContin", "Oxycontin", "OxyContin", "Oxycontin", "Oxycontin", "OxyContin", "OxyContin", "OxyContin", "OxyContin", "OxyContin", "OxyContin", "OxyContin", "OxyContin", "OxyContin", "OxyContin", "OxyContin", "OxyContin", "OxyContin", "OxyContin", "OxyContin", "OxyContin", "OxyContin", "OxyContin", "OxyContin", "OxyContin", "OxyContin", "OxyContin", "OxyContin", "OxyContin", "OxyContin", "OxyContin", "OxyContin", "OxyContin", "Oxycontin", "OxyContin", "OxyContin", "OxyContin", "OxyContin", "OxyContin", "OxyContin", "OxyContin", "OxyContin", "OxyContin", "OxyContin", "OxyContin", "OxyContin", "OxyContin", "OxyContin", "OxyContin", "Oxycontin 10mg", "Oxycontin 20mg", "Oxycontin 40mg", "Oxycontin 5mg", "Oxycontin 80mg", "Oxyneo", "Oxyneo", "Oxyneo", "Oxyneo", "Oxyneo", "Oxyneo", "Oxyneo", "Percocet", "Percocet", "Percocet", "Percocet", "Percocet", "Percocet", "Percocet", "Percocet", "Percocet", "Percocet", "Percocet", "Percocet", "Percocet", "Percocet", "Percocet", "Percocet", "Percocet", "Percocet", "Percocet", "Percocet", "Percocet-demi", "Percodan", "Percodan", "Percodan-demi", "PMS-oxycodone", "PMS-oxycodone", "PMS-oxycodone", "PMS-oxycodone - Acetaminophen", "PMS-oxycodone CR", "PMS-oxycodone CR", "PMS-oxycodone CR", "PMS-oxycodone CR", "PMS-oxycodone CR", "PMS-oxycodone CR", "PMS-oxycodone CR", "PMS-oxycodone CR", "Primlev", "Primlev", "Primlev", "Primlev", "Primlev", "Primlev", "Primlev", "Prolate", "Prolate", "Prolate", "Prolate", "Ran-oxycodone CR", "Ran-oxycodone CR", "Ran-oxycodone CR", "Ran-oxycodone CR", "Ran-oxycodone CR", "Riva-oxycodone CR", "Riva-oxycodone CR", "Riva-oxycodone CR", "Riva-oxycodone CR", "Rivacocet", "Rivacodan", "Roxicet", "Roxicet", "Roxicet", "Roxicet", "Roxicet", "Roxicet 5/500", "Roxicet Tab", "Roxicodone", "Roxicodone", "Roxicodone", "Roxicodone", "Roxicodone", "Roxicodone", "Roxicodone", "Roxicodone", "Roxicodone", "Roxybond", "Roxybond", "Roxybond", "Roxybond", "Roxybond", "Roxybond", "RoxyBond", "RoxyBond", "RoxyBond", "RoxyBond", "Sandoz Oxycodone CR", "Sandoz Oxycodone CR", "Sandoz Oxycodone CR", "Sandoz Oxycodone CR", "Sandoz Oxycodone CR", "Sandoz Oxycodone/acetaminophen", "Supeudol 10", "Supeudol 10", "Supeudol 20", "Supeudol 20", "Supeudol 5", "Targin", "Targin", "Targin", "Targin", "Targiniq ER", "Targiniq ER", "Targiniq ER", "Teva-oxycocet", "Teva-oxycodan", "Teva-oxycodone CR", "Teva-oxycodone CR", "Teva-oxycodone CR", "Teva-oxycodone CR", "Troxyca ER", "Troxyca ER", "Troxyca ER", "Troxyca ER", "Troxyca ER", "Troxyca ER", "Tylox", "Tylox", "Tylox", "Xartemis XR", "Xartemis XR", "Xolox", "Xtampza ER", "Xtampza ER", "Xtampza ER", "Xtampza ER", "Xtampza ER", "Xtampza ER" ]	[ "Oxanest", "OxyIR" ]	[ "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Percocet", "Percocet", "Oxycodone and Acetaminophen", "Percocet", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Xolox", "Oxycodone and Aspirin", "Oxycodone and Aspirin", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Tylox", "Percocet", "Endodan", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Endocet", "Oxycodone and Aspirin", "Oxycodone and Aspirin", "Tylox", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone Hydrochloride and Acetaminophen", "Oxycodone Hydrochloride and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Percocet", "Percocet", "Primlev", "Primlev", "Primlev", "Primlev", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Magnacet", "Magnacet", "Magnacet", "Percocet", "Percocet", "Percocet", "Percocet", "Oxycodone and Acetaminophen", "Endocet", "Endocet", "Endocet", "Endocet", "Endocet", "Oxycodone and Acetaminophen", "Oxycodone Hydrochloride and Acetaminophen", "Tylox", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone Hydrochloride and Ibuprofen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Endodan", "Oxycodone Hydrochloride and Ibuprofen", "Magnacet", "Magnacet", "Magnacet", "Combunox", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone Hydrochloride and Aspirin", "Oxycodone and Acetaminophen", "Percocet", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Roxicet", "Roxicet", "Roxicet", "Roxicet", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone Hydrochloride and Acetaminophen", "Oxycodone/apap", "Oxycodone Hydrochloride and Acetaminophen", "Roxicet", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Troxyca ER", "Troxyca ER", "Troxyca ER", "Troxyca ER", "Troxyca ER", "Troxyca ER", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Endocet", "Oxycodone hydrochloride and Ibuprofen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Endocet", "Endocet", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Xartemis XR", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Roxicet 5/500", "Oxycodone and Acetaminophen", "Oxycodone Hydrochloride and Acetaminophen", "Endocet", "Endocet", "Percocet", "Percocet", "Oxycodone and Acetaminophen", "Oxycodone Apap", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Xartemis XR", "Oxycodone and Acetaminophen", "Nalocet", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Endocet", "Endocet", "Endocet", "Endocet", "Percocet", "Percocet", "Percocet", "Percocet", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone/apap", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Aspirin", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone/APAP", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Aspirin", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Targiniq ER", "Targiniq ER", "Targiniq ER", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone Hydrochloride and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone Apap", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone Hydrochloride and Acetaminophen", "Prolate", "Prolate", "Prolate", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Primlev", "Primlev", "Primlev", "Prolate", "Oxycodone and Acetaminophen", "Oxycodone hydrochloride and Ibuprofen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Percodan", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Percocet", "Oxycodone Hydrochloride and Acetaminophen", "Oxycodone Hydrochloride and Acetaminophen", "Oxycodone Hydrochloride and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone Hydrochloride and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Endocet", "Endocet", "Endocet", "Endocet", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Targin", "Targin", "Targin", "Targin", "Sandoz Oxycodone/acetaminophen", "Apo-oxycodone/acet", "Oxycodone-acet", "Oxycodone/acet", "Roxicet Tab", "Percodan-demi", "Endodan", "Percodan", "Rivacodan", "Ntp-oxycodone Acetaminophen", "Oxycodone/acetaminophen", "Rivacocet", "PMS-oxycodone - Acetaminophen", "Teva-oxycocet", "Percocet", "Percocet-demi", "Endocet", "Teva-oxycodan", "Nu-oxycodone/acet", "Oxycodone Hydrochloride and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone/APAP", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Endocet", "Oxycodone/APAP", "Percocet", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Oxycodone/APAP", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen", "Endocet", "Oxycodone and Aspirin", "Oxycodone and Acetaminophen", "Oxycodone and Acetaminophen" ]	[ "P35372", "P41145", "P41143" ]	[ "P10635", "P08684", "P20815" ]	[ "P02768", "P02763", "P19652" ]	[]
DB00498	Phenindione	An indandione that has been used as an anticoagulant. Phenindione has actions similar to warfarin, but it is now rarely employed because of its higher incidence of severe adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p234)	solid	For the treatment of pulmonary embolism, cardiomyopathy, atrial fibrillation and flutter, cerebral embolism, mural thrombosis, and thrombophili. Also used for anticoagulant prophylaxis.	Phenindione thins the blood by antagonizing vitamin K which is required for the production of clotting factors in the liver. Anticoagulants such as Phenindione have no direct effect on an established thrombus, nor do they reverse ischemic tissue damage (damage caused by an inadequate blood supply to an organ or part of the body). However, once a thrombus has occurred, the goal of anticoagulant treatment is to prevent further extension of the formed clot and prevent secondary thromboembolic complications which may result in serious and possibly fatal sequelae. Phenindione has actions similar to warfarin, but it is now rarely employed because of its higer incidence of severe adverse effects.	Phenindione inhibits vitamin K reductase, resulting in depletion of the reduced form of vitamin K (vitamin KH2). As vitamin K is a cofactor for the carboxylation of glutamate residues on the N-terminal regions of vitamin K-dependent proteins, this limits the gamma-carboxylation and subsequent activation of the vitamin K-dependent coagulant proteins. The synthesis of vitamin K-dependent coagulation factors II, VII, IX, and X and anticoagulant proteins C and S is inhibited. Depression of three of the four vitamin K-dependent coagulation factors (factors II, VII, and X) results in decreased prothrombin levels and a decrease in the amount of thrombin generated and bound to fibrin. This reduces the thrombogenicity of clots.	Absorbed slowly from the gastrointestinal tract.	Hepatic.	Oral, mouse: LD50 = 175 mg/kg; Oral, rat: LD50 = 163 mg/kg.	5-10 hours	88%	null	null	null	Organic compounds	Benzenoids	Indanes	Indanones	[ "approved", "investigational" ]	[ "B01AA", "B01A", "B01", "B" ]	[ "Humans and other mammals" ]	[]	[]	2-phenyl-1,3-diketohydrindene \| 2-Phenyl-1,3-indandione \| 2-phenyl-1,3(2H)-Indenedione \| Fenindiona \| Fenindione \| Phenindion \| Phénindione \| Phenindione \| Phenindionum \| PID \| 1.17.4.4 \| Vitamin K1 2,3-epoxide reductase subunit 1 \| VKOR	[]	[ "Dindevan", "Fenindion", "Phenindione", "Soluthrombine" ]	[]	[ "Q9BQB6" ]	[]	[]	[]
DB00499	Flutamide	An antiandrogen with about the same potency as cyproterone in rodent and canine species.	solid	For the management of locally confined Stage B2-C and Stage D2 metastatic carcinoma of the prostate	Flutamide is a nonsteroidal antiandrogen. In animal studies, flutamide demonstrates potent antiandrogenic effects. It exerts its antiandrogenic action by inhibiting androgen uptake and/or by inhibiting nuclear binding of androgen in target tissues or both. Prostatic carcinoma is known to be androgen-sensitive and responds to treatment that counteracts the effect of androgen and/or removes the source of androgen, e.g. castration. Elevations of plasma testosterone and estradiol levels have been noted following flutamide administration.	Flutamide is a nonsteroidal antiandrogen that blocks the action of both endogenous and exogenous testosterone by binding to the androgen receptor. In addition Flutamide is a potent inhibitor of testosterone-stimulated prostatic DNA synthesis. Moreover, it is capable of inhibiting prostatic nuclear uptake of androgen.	Rapidly and completely absorbed.	Flutamide is rapidly and extensively metabolized, with flutamide comprising only 2.5% of plasma radioactivity 1 hour after administration.	In animal studies with flutamide alone, signs of overdose included hypoactivity, piloerection, slow respiration, ataxia, and/or lacrimation, anorexia, tranquilization, emesis, and methemoglobinemia.	The plasma half-life for the alpha-hydroxylated metabolite of flutamide (an active metabolite) is approximately 6 hours.	94-96%	Flutamide and its metabolites are excreted mainly in the urine with only 4.2% of a single dose excreted in the feces over 72 hours.	null	null	Organic compounds	Benzenoids	Benzene and substituted derivatives	Trifluoromethylbenzenes	[ "approved", "investigational" ]	[ "L02BB", "L02B", "L02", "L" ]	[ "Humans and other mammals" ]	[ { "cost": "2.12", "description": "Flutamide 125 mg capsule", "unit": "capsule" } ]	[]	4'-nitro-3'-trifluoromethylisobutyranilide \| Flutamid \| Flutamida \| Flutamide \| Flutamidum \| FTA \| NFBA \| Niftolid \| Niftolide \| α,α,α-trifluoro-2-methyl-4'-nitro-m-propionotoluidide \| DHTR \| Dihydrotestosterone receptor \| NR3C4 \| Nuclear receptor subfamily 3 group C member 4 \| Ah receptor \| AhR \| BHLHE76 \| Class E basic helix-loop-helix protein 76 \| Orphan nuclear receptor PAR1 \| Orphan nuclear receptor PXR \| Pregnane X receptor \| PXR \| Steroid and xenobiotic receptor \| SXR \| 1.14.14.1 \| CYPIA1 \| Cytochrome P450 form 6 \| Cytochrome P450-C \| Cytochrome P450-P1 \| Hydroperoxy icosatetraenoate dehydratase \| 1.14.14.1 \| CYPIB1 \| Hydroperoxy icosatetraenoate dehydratase \| 1.14.14.1 \| CYPIIIA5 \| Cytochrome P450-PCN3 \| 1.14.14.1 \| Cholesterol 25-hydroxylase \| CYPIA2 \| Cytochrome P(3)450 \| Cytochrome P450 4 \| Cytochrome P450-P3 \| Hydroperoxy icosatetraenoate dehydratase \| 1,4-cineole 2-exo-monooxygenase \| 1,8-cineole 2-exo-monooxygenase \| 1.14.14.1 \| Albendazole monooxygenase (sulfoxide-forming) \| Albendazole sulfoxidase \| Cholesterol 25-hydroxylase \| CYP3A3 \| CYPIIIA3 \| CYPIIIA4 \| Cytochrome P450 3A3 \| Cytochrome P450 HLp \| Cytochrome P450 NF-25 \| Cytochrome P450-PCN1 \| Nifedipine oxidase \| Quinine 3-monooxygenase \| 7.6.2.2 \| ATP-binding cassette sub-family C member 1 \| Glutathione-S-conjugate-translocating ATPase ABCC1 \| Leukotriene C(4) transporter \| LTC4 transporter \| MRP \| MRP1	[ "Dom-flutamide", "Euflex", "Eulexin", "Eulexin", "Eulexin", "Flutamide", "Flutamide", "Flutamide", "Flutamide", "Flutamide", "Flutamide", "Flutamide", "Flutamide", "Flutamide", "Flutamide", "Flutamide", "Flutamide", "Flutamide", "Flutamide-250", "Nu-flutamide Tablets", "Penta-flutamide", "PMS-flutamide", "Teva-flutamide" ]	[ "Andraxan", "Antipros", "Curestat", "Cytomid", "Dedile", "Drogenil", "Elbat", "Etaconil", "Farostat", "Flimutal", "Flucinom", "Flulem", "Odyne", "Prostadirex", "Prostanon" ]	[]	[ "P10275", "P35869", "O75469" ]	[ "P04798", "Q16678", "P20815", "P05177", "P08684" ]	[]	[ "P33527" ]
DB00500	Tolmetin	A non-steroidal anti-inflammatory agent (anti-inflammatory agents, NON-steroidal) similar in mode of action to indomethacin.	solid	For the relief of signs and symptoms of rheumatoid arthritis and osteoarthritis, including the treatment of acute flares long-term management. Also for treatment of juvenile rheumatoid arthritis.	Tolmetin is a nonsteroidal anti-inflammatory agent. Studies in animals have shown tolmetin to possess anti-inflammatory, analgesic and antipyretic activity. In the rat, tolmetin prevents the development of experimentally induced polyarthritis and also decreases established inflammation. In patients with either rheumatoid arthritis or osteaoarthritis, tolmetin is as effective as aspirin and indomethacin in controlling disease activity, but the frequency of the milder gastrointestinal adverse effects and tinnitus was less than in aspirin-treated patients, and the incidence of central nervous system adverse effects was less than in indomethacin-treated patients. In patients with juvenile rheumatoid arthritis, tolmetin is as effective as aspirin in controlling disease activity, with a similar incidence of adverse reactions. tolmetin has produced additional therapeutic benefit when added to a regimen of gold salts and, to a lesser extent, with corticosteroids. Tolmetin should not be used in conjunction with salicylates since greater benefit from the combination is not likely, but the potential for adverse reactions is increased.	The mode of action of tolmetin is not known. However, studies in laboratory animals and man have demonstrated that the anti-inflammatory action of tolmetin is not due to pituitary-adrenal stimulation. Tolmetin inhibits prostaglandin synthetase in vitro and lowers the plasma level of prostaglandin E in man. This reduction in prostaglandin synthesis may be responsible for the anti-inflammatory action. Tolmetin does not appear to alter the course of the underlying disease in man.	Rapidly and almost completely absorbed with peak plasma levels being reached within 30-60 minutes after an oral therapeutic dose.	Essentially all of the administered dose is recovered in the urine in 24 hours either as an inactive oxidative metabolite or as conjugates of tolmetin.	Symptoms of overdose include lethargy, drowsiness, nausea, vomiting, and epigastric pain.	Biphasic elimination from the plasma consisting of a rapid phase with a half-life of one to 2 hours followed by a slower phase with a half-life of about 5 hours.	null	null	null	null	Organic compounds	Organic oxygen compounds	Organooxygen compounds	Carbonyl compounds	[ "approved" ]	[ "M01AB", "M01A", "M01", "M", "M02AA", "M02A", "M02", "M" ]	[ "Humans and other mammals" ]	[ { "cost": "1.77", "description": "Tolmetin Sodium 400 mg capsule", "unit": "capsule" }, { "cost": "2.06", "description": "Tolmetin sodium 600 mg tablet", "unit": "tablet" }, { "cost": "2.43", "description": "Tolectin 600 mg tablet", "unit": "tablet" }, { "cost": "0.77", "description": "Tolmetin sodium 200 mg tablet", "unit": "tablet" } ]	[]	1-Methyl-5-(4-methylbenzoyl)-pyrrole-2-acetic acid \| 1-Methyl-5-p-toluoylpyrrole-2-acetic acid \| 5-(p-Toluoyl)-1-methylpyrrole-2-acetic acid \| Tolmetin \| Tolmetina \| Tolmétine \| Tolmetino \| Tolmetinum \| 1.14.99.1 \| COX-2 \| COX2 \| Cyclooxygenase-2 \| PGH synthase 2 \| PGHS-2 \| PHS II \| Prostaglandin H2 synthase 2 \| Prostaglandin-endoperoxide synthase 2 \| 1.14.99.1 \| COX-1 \| COX1 \| Cyclooxygenase-1 \| PGH synthase 1 \| PGHS-1 \| PHS 1 \| Prostaglandin H2 synthase 1 \| Prostaglandin-endoperoxide synthase 1 \| 1.13.11.11 \| TDO \| TO \| TRPO \| Tryptamin 2,3-dioxygenase \| Tryptophan oxygenase \| Tryptophan pyrrolase \| Tryptophanase \| 1.11.2.2 \| MPO \| hOAT1 \| hPAHT \| hROAT1 \| OAT1 \| Organic anion transporter 1 \| PAH transporter \| PAHT \| Renal organic anion transporter 1	[ "Novo-tolmetin Capsules 400mg", "Tolectin", "Tolectin 200 Tab 200mg", "Tolectin 400 Cap 400mg", "Tolectin Tab 600mg", "Tolmetin Sodium", "Tolmetin Sodium", "Tolmetin Sodium", "Tolmetin Sodium", "Tolmetin Sodium", "Tolmetin Sodium", "Tolmetin Sodium", "Tolmetin Sodium", "Tolmetin Sodium", "Tolmetin Sodium", "Tolmetin Sodium", "Tolmetin Sodium" ]	[ "Tolectin", "Tolectin DS" ]	[]	[ "P35354", "P23219" ]	[ "P48775", "P05164" ]	[ "P02768" ]	[ "Q4U2R8" ]
DB00501	Cimetidine	A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant therapy.	solid	Cimetidine is indicated to reduce gastric acid secretion and to treat the following disease states: duodenal ulcers, non-malignant gastric ulcers, gastroesophageal reflux disease, and pathological hypersecretion associated with Zollinger-Ellison Syndrome, systemic mastocytosis, and multiple endocrine adenomas.[L30280] It is indicated for prophylaxis of recurrent gastric or duodenal ulcers, as adjunctive therapy in the management of cystic fibrosis in children, and to treat NSAID induced lesions and gastrointestinal symptoms.[L30280]	Cimetidine is a histamine H<sub>2</sub>-receptor antagonist. It reduces basal and nocturnal gastric acid secretion and a reduction in gastric volume, acidity, and amount of gastric acid released in response to stimuli including food, caffeine, insulin, betazole, or pentagastrin. It is used to treat gastrointestinal disorders such as gastric or duodenal ulcer, gastroesophageal reflux disease, and pathological hypersecretory conditions. Cimetidine inhibits many of the isoenzymes of the hepatic CYP450 enzyme system. Other actions of Cimetidine include an increase in gastric bacterial flora such as nitrate-reducing organisms.	Cimetidine binds to an H<sub>2</sub>-receptor located on the basolateral membrane of the gastric parietal cell, blocking histamine effects. This competitive inhibition results in reduced gastric acid secretion and a reduction in gastric volume and acidity.	Two peak plasma concentrations are often observed after oral administration of cimetidine, likely as a result of discontinuous absorption in the gastrointestinal tract.[A226958] In healthy patients, the absolute bioavailability of cimetidine is approximately 60%; however, the bioavailability can be as high as 70% in patients with peptic ulcer disease.[A226958] Overall, rates of bioavailability are much more variable in patients with peptic ulcer disease.[A226958]	After intravenous administration of cimetidine, the majority of the parent drug (58-77%) is eliminated unchanged in the urine.[A226918,L30280] Cimetidine’s primary metabolite is cimetidine sulfoxide and represents an estimated 10-15% of total elimination.[A226918,A226958] Researchers have also identified a minor cimetidine metabolite with a hydroxylated methyl group on the imidazole ring which represents only 4% of total elimination.[A226918,A226958] Both cytochrome P450 enzymes and flavin-containing monooxygenases are implicated in the metabolism of cimetidine, although it is unclear which specific enzymes are involved.[A226933] Cimetidine is a well known enzyme inhibitor and may impair the metabolism of certain co-administered medications.[A226943]	In the rare event of cimetidine overdose, it is vital to maintain the airway and cardiovascular status.[A226848] The patient should be closely monitored and provided with symptomatic and supportive treatment as needed.[A226848] Interventions such as gastric lavage and administration of activated charcoal may be initiated if deemed appropriate and necessary.[A226848]	Cimetidine's half-life is estimated to be around 2 hours.[L30280]	In humans, approximately 22.5% of cimetidine is plasma protein bound.[L30280]	Cimetidine is excreted primarily in the urine.[L30280]	The volume of distribution of cimetidine is reported to be 1 L/kg.[A226958]	Cimetidine's reported systemic clearance value is approximately 500-600 ml/min.[A226958]	Organic compounds	Organoheterocyclic compounds	Azoles	Imidazoles	[ "approved", "investigational" ]	[ "A02BA", "A02B", "A02", "A", "A02BA", "A02B", "A02", "A" ]	[ "Humans and other mammals" ]	[ { "cost": "1.28", "description": "Tagamet 300 mg tablet", "unit": "tablet" }, { "cost": "1.44", "description": "Cimetidine 400 mg tablet", "unit": "tablet" }, { "cost": "1.48", "description": "Cimetidine powder", "unit": "g" }, { "cost": "1.67", "description": "Cimetidine 150 mg/ml vial", "unit": "ml" }, { "cost": "2.51", "description": "Tagamet 400 mg tablet", "unit": "tablet" }, { "cost": "2.7", "description": "Cimetidine 800 mg tablet", "unit": "tablet" }, { "cost": "0.08", "description": "Heartburn relief 200 mg tablet", "unit": "tablet" }, { "cost": "0.09", "description": "Apo-Cimetidine 200 mg Tablet", "unit": "tablet" }, { "cost": "0.09", "description": "Apo-Cimetidine 300 mg Tablet", "unit": "tablet" }, { "cost": "0.09", "description": "Mylan-Cimetidine 300 mg Tablet", "unit": "tablet" }, { "cost": "0.09", "description": "Novo-Cimetine 300 mg Tablet", "unit": "tablet" }, { "cost": "0.09", "description": "Nu-Cimet 300 mg Tablet", "unit": "tablet" }, { "cost": "0.14", "description": "Apo-Cimetidine 400 mg Tablet", "unit": "tablet" }, { "cost": "0.14", "description": "Mylan-Cimetidine 400 mg Tablet", "unit": "tablet" }, { "cost": "0.14", "description": "Novo-Cimetine 400 mg Tablet", "unit": "tablet" }, { "cost": "0.14", "description": "Nu-Cimet 400 mg Tablet", "unit": "tablet" }, { "cost": "0.18", "description": "Apo-Cimetidine 600 mg Tablet", "unit": "tablet" }, { "cost": "0.18", "description": "Mylan-Cimetidine 600 mg Tablet", "unit": "tablet" }, { "cost": "0.18", "description": "Novo-Cimetine 600 mg Tablet", "unit": "tablet" }, { "cost": "0.18", "description": "Nu-Cimet 600 mg Tablet", "unit": "tablet" }, { "cost": "0.21", "description": "Acid reducer 200 mg tablet", "unit": "tablet" }, { "cost": "0.27", "description": "Apo-Cimetidine 800 mg Tablet", "unit": "tablet" }, { "cost": "0.27", "description": "Mylan-Cimetidine 800 mg Tablet", "unit": "tablet" }, { "cost": "0.37", "description": "Tagamet hb 200 mg tablet", "unit": "tablet" }, { "cost": "0.38", "description": "Cimetidine HCl 300 mg/5ml Solution", "unit": "ml" }, { "cost": "0.46", "description": "Cimetidine 200 mg tablet", "unit": "tablet" }, { "cost": "0.93", "description": "Cimetidine 300 mg tablet", "unit": "tablet" } ]	[]	1-Cyano-2-methyl-3-(2-(((5-methyl-4-imidazolyl)methyl)thio)ethyl)guanidine \| 2-cyano-1-methyl-3-(2-(((5-methylimidazol-4-yl)methyl)thio)ethyl)guanidine \| Cimetidin \| Cimetidina \| Cimétidine \| Cimetidine \| Cimetidinum \| N-cyano-N'-methyl-N''-(2-([(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl)ethyl)guanidine \| N''-cyano-N-methyl-N'-(2-{[(5-methyl-1H-imidazol-4-yl)methyl]thio}ethyl)guanidine \| Gastric receptor I \| H2R \| HH2R \| CYP11B1 \| CYPXIB1 \| Cytochrome P-450c11 \| Cytochrome P450C11 \| S11BH \| Steroid 11-beta-hydroxylase, CYP11B1 \| 1.14.14.1 \| CYPIIC8 \| Cytochrome P450 form 1 \| Cytochrome P450 IIC2 \| Cytochrome P450 MP-12 \| Cytochrome P450 MP-20 \| S-mephenytoin 4-hydroxylase \| (R)-limonene 6-monooxygenase \| (S)-limonene 6-monooxygenase \| (S)-limonene 7-monooxygenase \| 1.14.14.1 \| Cholesterol 25-hydroxylase \| CYP2C10 \| CYPIIC9 \| Cytochrome P-450MP \| Cytochrome P450 MP-4 \| Cytochrome P450 MP-8 \| Cytochrome P450 PB-1 \| S-mephenytoin 4-hydroxylase \| 1.14.14.1 \| 4-nitrophenol 2-hydroxylase \| CYP2E \| CYPIIE1 \| Cytochrome P450-J \| 1.14.13.148 \| 1.14.13.32 \| 1.14.13.8 \| Dimethylaniline monooxygenase [N-oxide-forming] 3 \| Dimethylaniline oxidase 3 \| FMO 3 \| FMO form 2 \| FMO II \| Hepatic flavin-containing monooxygenase 3 \| Trimethylamine monooxygenase \| 1.14.13.148 \| 1.14.13.8 \| Dimethylaniline monooxygenase [N-oxide-forming] 1 \| Dimethylaniline oxidase 1 \| Fetal hepatic flavin-containing monooxygenase 1 \| FMO 1 \| Trimethylamine monooxygenase \| 1.14.14.1 \| Cholesterol 25-hydroxylase \| CYPIA2 \| Cytochrome P(3)450 \| Cytochrome P450 4 \| Cytochrome P450-P3 \| Hydroperoxy icosatetraenoate dehydratase \| 1.14.14.- \| Cholesterol 25-hydroxylase \| CYP2DL1 \| CYPIID6 \| Cytochrome P450-DB1 \| Debrisoquine 4-hydroxylase \| (R)-limonene 6-monooxygenase \| (S)-limonene 6-monooxygenase \| (S)-limonene 7-monooxygenase \| 1.14.14.1 \| CYPIIC17 \| CYPIIC19 \| Cytochrome P450-11A \| Cytochrome P450-254C \| Fenbendazole monooxygenase (4'-hydroxylating) \| Mephenytoin 4-hydroxylase \| 1,4-cineole 2-exo-monooxygenase \| 1,8-cineole 2-exo-monooxygenase \| 1.14.14.1 \| Albendazole monooxygenase (sulfoxide-forming) \| Albendazole sulfoxidase \| Cholesterol 25-hydroxylase \| CYP3A3 \| CYPIIIA3 \| CYPIIIA4 \| Cytochrome P450 3A3 \| Cytochrome P450 HLp \| Cytochrome P450 NF-25 \| Cytochrome P450-PCN1 \| Nifedipine oxidase \| Quinine 3-monooxygenase \| 1.14.14.1 \| CYPIIIA5 \| Cytochrome P450-PCN3 \| ATP-binding cassette sub-family B member 1 \| MDR1 \| Multidrug resistance protein 1 \| P-glycoprotein 1 \| PGY1 \| Phospholipid transporter ABCB1 \| hOCT2 \| OCT2 \| Organic cation transporter 2 \| hOCT1 \| OCT1 \| Organic cation transporter 1 \| EMT \| EMTH \| Extraneuronal monoamine transporter \| OCT3 \| Organic cation transporter 3 \| High-affinity sodium-dependent carnitine cotransporter \| OCTN2 \| Solute carrier family 22 member 5 \| hOAT1 \| hPAHT \| hROAT1 \| OAT1 \| Organic anion transporter 1 \| PAH transporter \| PAHT \| Renal organic anion transporter 1 \| hOAT3 \| OAT3 \| Organic anion/dicarboxylate exchanger \| Solute carrier family 22 member 8 \| hMATE-1 \| MATE-1 \| MATE1 \| Solute carrier family 47 member 1 \| Ergothioneine transporter \| ET transporter \| ETT \| ETTh \| OCTN1 \| Organic cation/carnitine transporter 1 \| UT2H \| OAT4 \| Organic anion transporter 4 \| Organic anion:dicarboxylate exchanger OAT4 \| hOAT2 \| NLT \| Novel liver transporter \| OAT2 \| Organic anion transporter 2 \| 7.6.2.- \| ATP-binding cassette sub-family B member 11 \| BSEP \| hMATE-2 \| Kidney-specific H(+)/organic cation antiporter \| MATE-2 \| MATE2 \| Solute carrier family 47 member 2	[ "Acid Reducer", "Acid Reducer", "Apo-cimetidine Oral Solution", "Basic Care Acid Reducer", "Cimetidine", "Cimetidine", "Cimetidine", "Cimetidine", "Cimetidine", "Cimetidine", "Cimetidine", "Cimetidine", "Cimetidine", "Cimetidine", "Cimetidine", "Cimetidine", "Cimetidine", "Cimetidine", "Cimetidine", "Cimetidine", "Cimetidine", "Cimetidine", "Cimetidine", "Cimetidine", "Cimetidine", "Cimetidine", "Cimetidine", "Cimetidine", "Cimetidine", "Cimetidine", "Cimetidine", "Cimetidine", "Cimetidine", "Cimetidine", "Cimetidine", "Cimetidine", "Cimetidine", "Cimetidine", "Cimetidine", "Cimetidine", "Cimetidine", "Cimetidine", "Cimetidine", "Cimetidine", "Cimetidine", "Cimetidine", "Cimetidine", "Cimetidine", "Cimetidine", "Cimetidine", "Cimetidine", "Cimetidine", "Cimetidine", "Cimetidine", "Cimetidine", "Cimetidine", "Cimetidine", "Cimetidine", "Cimetidine", "Cimetidine", "Cimetidine", "Cimetidine", "Cimetidine", "Cimetidine", "Cimetidine", "Cimetidine", "Cimetidine", "Cimetidine", "Cimetidine", "Cimetidine", "Cimetidine", "Cimetidine", "Cimetidine", "Cimetidine", "Cimetidine", "Cimetidine", "Cimetidine", "Cimetidine", "Cimetidine 10% / Lidocaine 5% / Salicylic Acid 40%", "Cimetidine 200 Tab 200mg", "Cimetidine 5% / Ibuprofen 2% / Salicylic Acid 17%", "Cimetidine Acid Reducer", "Cimetidine Hydrochloride", "Cimetidine Hydrochloride", "Cimetidine Hydrochloride", "Cimetidine Hydrochloride", "Cimetidine Hydrochloride", "Cimetidine Hydrochloride", "Cimetidine Hydrochloride Oral Solution", "Cimetidine in Sodium Chloride", "Cimetidine Tab 300mg", "Cimetidine Tab 400mg", "Cimetidine Tab 600mg", "DG Health Heartburn Relief", "Dom-cimetidine", "Dom-cimetidine", "Dom-cimetidine", "Dom-cimetidine", "Dom-cimetidine", "Equaline Acid Reducer", "Equate Cimetidine", "Gaviscon All-night", "Gaviscon Prevent", "Gen-cimetidine Tablets 200mg", "Good Neighbor Pharmacy Heartburn Relief", "Good Sense Heartburn Relief", "Good Sense Heartburn Relief", "Harris Teeter Acid Reducer", "Heartburn Prevention", "Heartburn Relief", "Heartburn Relief", "Heartburn Relief", "Leader Heartburn Relief", "Mylan-cimetidine", "Mylan-cimetidine", "Mylan-cimetidine", "Mylan-cimetidine", "Novo-cimetine", "Novo-cimetine", "Novo-cimetine", "Novo-cimetine", "Novo-cimetine", "Novo-cimetine Injection", "Nu-cimet Tab 200mg", "Nu-cimet Tab 300mg", "Nu-cimet Tab 400mg", "Nu-cimet Tab 600mg", "Peptol Tab 200mg", "Peptol Tab 300mg", "Peptol Tab 400mg", "Peptol Tab 600mg", "Peptol Tab 800mg", "PMS-cimetidine", "PMS-cimetidine", "PMS-cimetidine", "PMS-cimetidine", "PMS-cimetidine", "Smart Sense Acid Reducer", "SunMark heartburn relief acid reducer", "Tagamet", "Tagamet", "Tagamet", "Tagamet 300", "Tagamet 400", "Tagamet 600", "Tagamet HB", "Tagamet Infusion 6mg/ml", "Tagamet Inj 150mg/ml", "Tagamet Liq 300mg/5ml", "Tagamet Liquid 60mg/ml", "Tagamet Prevent", "TopCare Heartburn Relief", "Up and Up Acid Reducer" ]	[ "Cimetag", "Tagamet HB 200", "Tagamet HB200", "Ulcedine", "Ulcerfen", "Ulcimet" ]	[ "Cimetidine 10% / Lidocaine 5% / Salicylic Acid 40%", "Cimetidine 5% / Ibuprofen 2% / Salicylic Acid 17%" ]	[ "P25021" ]	[ "P15538", "P10632", "P11712", "P05181", "P31513", "Q01740", "P05177", "P10635", "P33261", "P08684", "P20815" ]	[ "P02768" ]	[ "P08183", "O15244", "O15245", "O75751", "O76082", "Q4U2R8", "Q8TCC7", "Q96FL8", "Q9H015", "Q9NSA0", "Q9Y694", "O95342", "Q86VL8" ]
DB00502	Haloperidol	Haloperidol is a high potency first-generation (typical) antipsychotic and one of the most frequently used antipsychotic medications used worldwide.[A180616] While haloperidol has demonstrated pharmacologic activity at a number of receptors in the brain,[A27477] it exerts its antipsychotic effect through its strong antagonism of the dopamine receptor (mainly D2), particularly within the mesolimbic and mesocortical systems of the brain. Haloperidol is indicated for the treatment of the manifestations of several psychotic disorders including schizophrenia, acute psychosis, Tourette syndrome, and other severe behavioural states.[F4645] It is also used off-label for the management of chorea associated with Huntington's disease and for the treatment of intractable hiccups as it is a potent antiemetic. Dopamine-antagonizing medications such as haloperidol are though to improve psychotic symptoms and states that are caused by an over-production of dopamine, such as schizophrenia, which is theorized to be caused by a hyperdopaminergic state within the limbic system of the brain.[A34360] Use of the first-generation antipsychotics (including haloperidol) is considered highly effective for the management of the "positive" symptoms of schizophrenia including hallucinations, hearing voices, aggression/hostility, disorganized speech, and psychomotor agitation. However, this class of drugs is also limited by the development of movement disorders induced by dopamine-blockade such as drug-induced parkinsonism, akathisia, dystonia, tardive dyskinesia, as well as other side effects including sedation, weight gain, and prolactin changes. While there are limited high-quality studies comparing haloperidol to lower-potency first-generation antipsychotics such as [DB00477], [DB01624], [DB00623], and [DB01403], haloperidol typically demonstrates the least amount of side effects within this class, but demonstrates a stronger disposition for causing extrapyramidal symptoms (EPS).[A180613, A180616, A180625] These other low‐potency antipsychotics are limited by their lower affinity for dopamine receptors, which requires a higher dose to effectively treat symptoms of schizophrenia. In addition, they block many receptors other than the primary target (dopamine receptors), such as cholinergic or histaminergic receptors, resulting in a higher incidence of side effects such as sedation, weight gain, and hypotension. Interestingly, in vivo pharmacogenetic studies have demonstrated that the metabolism of haloperidol may be modulated by genetically determined polymorphic _CYP2D6_ activity. However, these findings contradict the findings from studies in vitro with human liver microsomes and from drug interaction studies in vivo. Inter-ethnic and pharmacogenetic differences in haloperidol metabolism may possibly explain these observations.[A32346] First-generation antipsychotic drugs have largely been replaced with second- and third-generation (atypical) antipsychotics such as [DB00734], [DB00334], [DB00363], [DB01224], [DB01238], and [DB00246]. However, haloperidol use remains widespread and is considered the benchmark for comparison in trials of the newer generation antipsychotics.[A180625] The efficacy of haloperidol was first established in controlled trials in the 1960s.[A180610]	solid	Haloperidol is indicated for a number of conditions including for the treatment of schizophrenia, for the manifestations of psychotic disorders, for the control of tics and vocal utterances of Tourette’s Disorder in children and adults, for treatment of severe behavior problems in children of combative, explosive hyperexcitability (which cannot be accounted for by immediate provocation). Haloperidol is also indicated in the short-term treatment of hyperactive children who show excessive motor activity with accompanying conduct disorders consisting of some or all of the following symptoms: impulsivity, difficulty sustaining attention, aggressivity, mood lability, and poor frustration tolerance. Haloperidol should be reserved for these two groups of children only after failure to respond to psychotherapy or medications other than antipsychotics.[F4645]	Use of the first-generation antipsychotics (including haloperidol) is considered highly effective for the management of the "positive" symptoms of schizophrenia including hallucinations, hearing voices, aggression/hostility, disorganized speech, and psychomotor agitation. However, this class is limited by the development of movement disorders such as drug-induced parkinsonism, akathisia, dystonia, and tardive dyskinesia, and other side effects including sedation, weight gain, and prolactin changes. Compared to the lower-potency first-generation antipsychotics such as [DB00477], [DB01624], [DB00623], and [DB01403], haloperidol typically demonstrates the least amount of side effects within class, but demonstrates a stronger disposition for causing extrapyramidal symptoms (EPS).[A180613, A180616, A180625] Low‐potency medications have a lower affinity for dopamine receptors so that a higher dose is required to effectively treat symptoms of schizophrenia. In addition, they block many receptors other than the primary target (dopamine receptors), such as cholinergic or histaminergic receptors, resulting in a higher incidence of side effects such as sedation, weight gain, and hypotension. The balance between the wanted drug effects on psychotic symptoms and unwanted side effects are largely at play within dopaminergic brain pathways affected by haloperidol. Cortical dopamine-D2-pathways play an important role in regulating these effects and include the nigrostriatal pathway, which is responsible for causing extrapyramidal symptoms (EPS), the mesolimbic and mesocortical pathways, which are responsible for the improvement in positive schizophrenic symptoms, and the tuberoinfundibular dopamine pathway, which is responsible for hyperprolactinemia. A syndrome consisting of potentially irreversible, involuntary, dyskinetic movements may develop in patients. Although the prevalence of the syndrome appears to be highest among the elderly, especially elderly women, it is impossible to rely upon prevalence estimates to predict, at the inception of antipsychotic treatment, which patients are likely to develop the syndrome.[F4645] Cases of sudden death, QT-prolongation, and Torsades de Pointes have been reported in patients receiving haloperidol. Higher than recommended doses of any formulation and intravenous administration of haloperidol appear to be associated with a higher risk of QT-prolongation and Torsades de Pointes. Although cases have been reported even in the absence of predisposing factors, particular caution is advised in treating patients with other QT-prolonging conditions (including electrolyte imbalance [particularly hypokalemia and hypomagnesemia], drugs known to prolong QT, underlying cardiac abnormalities, hypothyroidism, and familial long QT-syndrome).[F4645] A potentially fatal symptom complex sometimes referred to as Neuroleptic Malignant Syndrome (NMS) has been reported in association with antipsychotic drugs. Clinical manifestations of NMS are hyperpyrexia, muscle rigidity, altered mental status (including catatonic signs) and evidence of autonomic instability (irregular pulse or blood pressure, tachycardia, diaphoresis, and cardiac dysrhythmias). Additional signs may include elevated creatine phosphokinase, myoglobinuria (rhabdomyolysis) and acute renal failure.[F4645]	While haloperidol has demonstrated pharmacologic activity at a number of receptors in the brain, it exerts its antipsychotic effect through its strong antagonism of the dopamine receptor (mainly D2), particularly within the mesolimbic and mesocortical systems of the brain. Schizophrenia is theorized to be caused by a hyperdopaminergic state within the limbic system of the brain.[A34360] Dopamine-antagonizing medications such as haloperidol, therefore, are thought to improve psychotic symptoms by halting this over-production of dopamine. The optimal clinical efficacy of antipsychotics is associated with the blockade of approximately 60 % - 80 % of D2 receptors in the brain.[A34360] While the exact mechanism is not entirely understood, haloperidol is known to inhibit the effects of dopamine and increase its turnover. Traditional antipsychotics, such as haloperidol, bind more tightly than dopamine itself to the dopamine D2 receptor, with dissociation constants that are lower than that for dopamine.[A4962] It is believed that haloperidol competitively blocks post-synaptic dopamine (D2) receptors in the brain, eliminating dopamine neurotransmission and leading to the relief of delusions and hallucinations that are commonly associated with psychosis. It acts primarily on the D2-receptors and has some effect on 5-HT2 and α1-receptors, with negligible effects on dopamine D1-receptors. The drug also exerts some blockade of α-adrenergic receptors of the autonomic system.[L2022] Antagonistic activity regulated through dopamine D2 receptors in the chemoreceptive trigger zone (CTZ) of the brain renders its antiemetic activity. Of the three D2-like receptors, only the D2 receptor is blocked by antipsychotic drugs in direct relation to their clinical antipsychotic abilities. Clinical brain-imaging findings show that haloperidol remains tightly bound to D2 dopamine receptors in humans undergoing 2 positron emission tomography (PET) scans with a 24h pause in between scans.[A4962] A common adverse effect of this drug is the development of extrapyramidal symptoms (EPS), due to this tight binding of haloperidol to the dopamine D2 receptor. Due to the risk of unpleasant and sometimes lifelong extrapyramidal symptoms, newer antipsychotic medications than haloperidol have been discovered and formulated. Rapid dissociation of drugs from dopamine D2 receptors is a plausible explanation for the improved EPS profile of atypical antipsychotics such as [DB00734]. This is also consistent with the theory of a lower affinity for D2 receptors for these drugs. As mentioned above, haloperidol binds tightly to the dopamine receptor, potentiating the risk of extrapyramidal symptoms,[A4962] and therefore should only been used when necessary.	Haloperidol is a highly lipophilic compound and is extensively metabolized in humans, which may cause a large interindividual variability in its pharmacokinetics.[A32346] Studies have found a wide variance in pharmacokinetic values for orally administered haloperidol with 1.7-6.1 hours reported for time to peak plasma concentration (tmax), 14.5-36.7 hours reported for half-life (t1⁄2), and 43.73 μg/L•h [range 14.89-120.96 μg/L•h] reported for AUC.[A32346] Haloperidol is well-absorbed from the gastrointestinal tract when ingested orally, however, the first-pass hepatic metabolism decreases its oral bioavailability to 40 - 75%. After intramuscular administration, the time to peak plasma concentration (tmax) is 20 minutes in healthy individuals or 33.8 minutes in patients with schizophrenia, with a mean half-life of 20.7 hours.[A32346] Bioavailability following intramuscular administration is higher than that for oral administration. Administration of haloperidol decanoate (the depot form of haloperidol for long-term treatment) in sesame oil results in slow release of the drug for long-term effects. The plasma concentrations of haloperidol gradually rise, reaching its peak concentration at about 6 days after the injection, with an apparent half-life of about 21 days. Steady-state plasma concentrations are achieved after the third or fourth dose.[F4645]	Haloperidol is extensively metabolised in the liver with only about 1% of the administered dose excreted unchanged in urine.[A32346] In humans, haloperidol is biotransformed to various metabolites, including p-fluorobenzoylpropionic acid, 4-(4-chlorophenyl)-4-hydroxypiperidine, reduced haloperidol, pyridinium metabolites, and haloperidol glucuronide. In psychiatric patients treated regularly with haloperidol, the concentration of haloperidol glucuronide in plasma is the highest among the metabolites, followed, in rank order, by unchanged haloperidol, reduced haloperidol and reduced haloperidol glucuronide. The drug is thought to be metabolized primarily by oxidative N-dealkylation of the piperidine nitrogen to form fluorophenylcarbonic acids and piperidine metabolites (which appear to be inactive), and by reduction of the butyrophenone carbonyl to the carbinol, forming _hydroxyhaloperidol_. The enzymes involved in the biotransformation of haloperidol include cytochrome P450 (CYP) including CYP3A4 and CYP2D6, carbonyl reductase and uridine di-phosphoglucose glucuronosyltransferase enzymes. The greatest proportion of the intrinsic hepatic clearance of haloperidol is performed by glucuronidation and followed by the reduction of haloperidol to reduced haloperidol and by CYP-mediated oxidation. In studies of cytochrome-mediated disposition in vitro, CYP3A4 appears to be the major isoform of the enzyme responsible for the metabolism of haloperidol in humans. The intrinsic clearance of the back-oxidation of reduced haloperidol to the parent compound, oxidative N-dealkylation and pyridinium formation are of the same order of magnitude. This suggests that the same enzyme system is responsible for the above three metabolic reactions. In vivo human studies on haloperidol metabolism have shown that the glucuronidation of haloperidol accounts for 50 to 60% of haloperidol biotransformation and that approximately 23% of the biotransformation was accounted for by the reduction pathway. The remaining 20 to 30% ofthe biotransformation of haloperidol would be via N-dealkylation and pyridinium formation.[A32346]	Acute oral toxicity (LD50): 71 mg/kg in rats [MSDS].	Following oral administration, the half-life was found to be 14.5-36.7 hours. Following intramuscular injection, mean half-life was found to be 20.7 hours.[A32346]	Studies have found that free fraction of haloperidol in human plasma is 7.5-11.6%. This was found to be comparable among healthy adults, young adults, elderly patients with schizophrenia, and even in patients with liver cirrhosis.[A32346]	In radiolabeling studies, approximately 30% of the radioactivity is excreted in the urine following a single oral administration of 14C-labelled haloperidol, while 18% is excreted in the urine as haloperidol glucuronide, demonstrating that haloperidol glucuronide is a major metabolite in the urine as well as in plasma in humans.[A32346]	The apparent volume of distribution was found to range from 9.5-21.7 L/kg.[A32346] This high volume of distribution is in accordance with its lipophilicity, which also suggests free movement through various tissues including the blood-brain barrier.	Following intravenous administration, the plasma or serum clearance (CL) was found to be 0.39-0.708 L/h/kg (6.5 to 11.8 ml/min/kg). Following oral administration, clearance was found to be 141.65 L/h (range 41.34 to 335.80 L/h).[A32346] Haloperidol clearance after extravascular administration ranges from 0.9-1.5 l/h/kg, however this rate is reduced in poor metabolizers of C_YP2D6_ enzyme. Reduced CYP2D6 enzyme activity may result in increased concentrations of haloperidol. The inter-subject variability (coefficient of variation, %) in haloperidol clearance was estimated to be 44% in a population pharmacokinetic analysis in patients with schizophrenia [L2028]. Genetic polymorphism of CYP2D6 has been demonstrated to be an important source of inter-patient variability in the pharmacokinetics of haloperidol and may affect therapeutic response and incidence of adverse effects.[A32346]	Organic compounds	Organic oxygen compounds	Organooxygen compounds	Carbonyl compounds	[ "approved" ]	[ "N05AD", "N05A", "N05", "N" ]	[ "Humans and other mammals" ]	[ { "cost": "1.46", "description": "Haloperidol 10 mg tablet", "unit": "tablet" }, { "cost": "2.81", "description": "Haloperidol 20 mg tablet", "unit": "tablet" }, { "cost": "3.54", "description": "Haloperidol lac 5 mg/ml vial", "unit": "ml" }, { "cost": "4.73", "description": "Haloperidol 5 mg/ml", "unit": "ml" }, { "cost": "7.71", "description": "Haloperidol La 50 mg/ml", "unit": "ml" }, { "cost": "13.4", "description": "Haldol 5 mg/ml ampul", "unit": "ml" }, { "cost": "15.42", "description": "Haloperidol La 100 mg/ml", "unit": "ml" }, { "cost": "17.71", "description": "Haloperidol dec 50 mg/ml vial", "unit": "ml" }, { "cost": "21.42", "description": "Haloperidol powder", "unit": "g" }, { "cost": "29.85", "description": "Haloperidol dec 100 mg/ml vial", "unit": "ml" }, { "cost": "56.53", "description": "Haldol decanoate 50 ampul", "unit": "ml" }, { "cost": "107.77", "description": "Haldol decanoate 100 ampul", "unit": "ml" }, { "cost": "257.14", "description": "Haloperidol Decanoate 100 mg/ml Solution 5ml Vial", "unit": "vial" }, { "cost": "0.04", "description": "Apo-Haloperidol 0.5 mg Tablet", "unit": "tablet" }, { "cost": "0.04", "description": "Novo-Peridol 0.5 mg Tablet", "unit": "tablet" }, { "cost": "0.06", "description": "Apo-Haloperidol 1 mg Tablet", "unit": "tablet" }, { "cost": "0.06", "description": "Novo-Peridol 1 mg Tablet", "unit": "tablet" }, { "cost": "0.11", "description": "Apo-Haloperidol 2 mg Tablet", "unit": "tablet" }, { "cost": "0.11", "description": "Novo-Peridol 2 mg Tablet", "unit": "tablet" }, { "cost": "0.14", "description": "Apo-Haloperidol 10 mg Tablet", "unit": "tablet" }, { "cost": "0.14", "description": "Novo-Peridol 10 mg Tablet", "unit": "tablet" }, { "cost": "0.16", "description": "Apo-Haloperidol 5 mg Tablet", "unit": "tablet" }, { "cost": "0.16", "description": "Novo-Peridol 5 mg Tablet", "unit": "tablet" }, { "cost": "0.18", "description": "Pernox scrub cleanser", "unit": "g" }, { "cost": "0.25", "description": "Haloperidol 0.5 mg tablet", "unit": "tablet" }, { "cost": "0.36", "description": "Haloperidol 1 mg tablet", "unit": "tablet" }, { "cost": "0.45", "description": "Haloperidol lac 2 mg/ml conc", "unit": "ml" }, { "cost": "0.49", "description": "Haloperidol 2 mg tablet", "unit": "tablet" }, { "cost": "0.66", "description": "Novo-Peridol 20 mg Tablet", "unit": "tablet" }, { "cost": "0.8", "description": "Haloperidol 5 mg tablet", "unit": "tablet" } ]	[]	1-(3-p-fluorobenzoylpropyl)-4-p-chlorophenyl-4-hydroxypiperidine \| 4-(4-(para-chlorophenyl)-4-hydroxypiperidino)-4'-fluorobutyrophenone \| 4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidyl]-1-(4-fluorophenyl)-butan-1-one \| 4'-fluoro-4-(4-(p-chlorophenyl)-4-hydroxypiperidinyl)butyrophenone \| 4'-fluoro-4-(4-hydroxy-4-(4'-chlorophenyl)piperidino)butyrophenone \| Haloperidol \| Haloperidolum \| γ-(4-(p-chlorophenyl)-4-hydroxpiperidino)-p-fluorbutyrophenone \| 5-HT-1C \| 5-HT-2C \| 5-HT1C \| 5-HT2C \| 5-HTR2C \| 5-hydroxytryptamine receptor 1C \| HTR1C \| Serotonin receptor 2C \| Dopamine D2 receptor \| 5-HT-2 \| 5-HT-2A \| HTR2 \| Serotonin receptor 2A \| Dopamine D3 receptor \| G-protein coupled receptor 24 \| GPR24 \| MCH receptor 1 \| MCH-1R \| MCH-R1 \| MCH1R \| MCHR \| MCHR-1 \| SLC-1 \| SLC1 \| Somatostatin receptor-like protein \| Solute carrier family 18 member 2 \| SVMT \| VAT2 \| Vesicular amine transporter 2 \| Vesicular monoamine transporter 2 \| VMAT2 \| Aging-associated gene 8 protein \| hSigmaR1 \| OPRS1 \| SIG-1R \| Sigma 1-type opioid receptor \| Sigma1-receptor \| Sigma1R \| SR-BP \| SR31747-binding protein \| SRBP \| H1-R \| H1R \| HH1R \| ADRA1C \| Alpha-1A adrenoceptor \| Alpha-1A adrenoreceptor \| Alpha-1C adrenergic receptor \| Alpha-adrenergic receptor 1c \| ADRA2R \| ADRAR \| Alpha-2 adrenergic receptor subtype C10 \| Alpha-2A adrenoceptor \| Alpha-2A adrenoreceptor \| Alpha-2AAR \| ADRA2L1 \| ADRA2RL1 \| Alpha-2 adrenergic receptor subtype C2 \| Alpha-2B adrenoceptor \| Alpha-2B adrenoreceptor \| Alpha-2BAR \| ADRA2L2 \| ADRA2RL2 \| Alpha-2 adrenergic receptor subtype C4 \| Alpha-2C adrenoceptor \| Alpha-2C adrenoreceptor \| Alpha-2CAR \| 5-HT-1A \| 5-HT1A \| ADRB2RL1 \| ADRBRL1 \| G-21 \| Serotonin receptor 1A \| 5-HT-6 \| 5-HT6 \| Serotonin receptor 6 \| 5-HT-7 \| 5-HT-X \| 5-HT7 \| Serotonin receptor 7 \| GluN2B \| Glutamate [NMDA] receptor subunit epsilon-2 \| hNR3 \| N-methyl D-aspartate receptor subtype 2B \| N-methyl-D-aspartate receptor subunit 3 \| NMDAR2B \| NR2B \| NR3 \| Dopamine D1 receptor \| 1.1.1.184 \| 15-hydroxyprostaglandin dehydrogenase [NADP(+)] \| 20-beta-hydroxysteroid dehydrogenase \| Alcohol dehydrogenase [NAD(P)+] CBR1 \| CBR \| CRN \| NADPH-dependent carbonyl reductase 1 \| PG-9-KR \| Prostaglandin 9-ketoreductase \| Prostaglandin-E(2) 9-reductase \| SDR21C1 \| Short chain dehydrogenase/reductase family 21C member 1 \| 2.4.1.17 \| GNT1 \| lugP4 \| UDP-glucuronosyltransferase 1-9 \| UDP-glucuronosyltransferase 1-I \| UDPGT 1-9 \| UGT-1I \| UGT1 \| UGT1-09 \| UGT1.9 \| UGT1*9 \| UGT1A9 \| UGT1I \| (R)-limonene 6-monooxygenase \| (S)-limonene 6-monooxygenase \| (S)-limonene 7-monooxygenase \| 1.14.14.1 \| CYPIIC17 \| CYPIIC19 \| Cytochrome P450-11A \| Cytochrome P450-254C \| Fenbendazole monooxygenase (4'-hydroxylating) \| Mephenytoin 4-hydroxylase \| (R)-limonene 6-monooxygenase \| (S)-limonene 6-monooxygenase \| (S)-limonene 7-monooxygenase \| 1.14.14.1 \| Cholesterol 25-hydroxylase \| CYP2C10 \| CYPIIC9 \| Cytochrome P-450MP \| Cytochrome P450 MP-4 \| Cytochrome P450 MP-8 \| Cytochrome P450 PB-1 \| S-mephenytoin 4-hydroxylase \| 1.14.14.1 \| CYPIA1 \| Cytochrome P450 form 6 \| Cytochrome P450-C \| Cytochrome P450-P1 \| Hydroperoxy icosatetraenoate dehydratase \| 1.14.14.1 \| Cholesterol 25-hydroxylase \| CYPIA2 \| Cytochrome P(3)450 \| Cytochrome P450 4 \| Cytochrome P450-P3 \| Hydroperoxy icosatetraenoate dehydratase \| 1.14.14.- \| Cholesterol 25-hydroxylase \| CYP2DL1 \| CYPIID6 \| Cytochrome P450-DB1 \| Debrisoquine 4-hydroxylase \| 1.14.14.1 \| CYPIIIA5 \| Cytochrome P450-PCN3 \| 1,4-cineole 2-exo-monooxygenase \| 1,8-cineole 2-exo-monooxygenase \| 1.14.14.1 \| Albendazole monooxygenase (sulfoxide-forming) \| Albendazole sulfoxidase \| Cholesterol 25-hydroxylase \| CYP3A3 \| CYPIIIA3 \| CYPIIIA4 \| Cytochrome P450 3A3 \| Cytochrome P450 HLp \| Cytochrome P450 NF-25 \| Cytochrome P450-PCN1 \| Nifedipine oxidase \| Quinine 3-monooxygenase \| 1.14.14.1 \| CYPIIIA7 \| Cytochrome P450-HFLA \| P450HLp2 \| ATP-binding cassette sub-family B member 1 \| MDR1 \| Multidrug resistance protein 1 \| P-glycoprotein 1 \| PGY1 \| Phospholipid transporter ABCB1	[ "Apo Haloperidol Tab 0.5mg", "Apo Haloperidol Tab 1mg", "Apo-haloperidol LA Injectable", "Apo-haloperidol LA Injectable", "Apo-haloperidol Liq 2mg/ml", "Apo-haloperidol Tab 10mg", "Apo-haloperidol Tab 2mg", "Apo-haloperidol Tab 5mg", "Haldol", "Haldol", "Haldol Decanoate", "Haldol Decanoate", "Haldol Decanoate", "Haldol Decanoate", "Haldol Decanoate", "Haldol Injection 5mg/ml", "Haldol LA Inj 100mg/ml", "Haldol LA Inj 50mg/ml", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol", "Haloperidol Decanoate", "Haloperidol Decanoate", "Haloperidol Decanoate", "Haloperidol Decanoate", "Haloperidol Decanoate", "Haloperidol Decanoate", "Haloperidol Decanoate", "Haloperidol decanoate", "Haloperidol decanoate", "Haloperidol Decanoate", "Haloperidol Decanoate", "Haloperidol Decanoate", "Haloperidol Decanoate", "Haloperidol Decanoate", "Haloperidol Decanoate", "Haloperidol Decanoate", "Haloperidol Decanoate", "Haloperidol Decanoate", "Haloperidol Decanoate", "Haloperidol Decanoate", "Haloperidol Decanoate", "Haloperidol Decanoate", "Haloperidol Decanoate", "Haloperidol Decanoate", "Haloperidol Decanoate", "Haloperidol Decanoate", "Haloperidol Decanoate", "Haloperidol Decanoate", "Haloperidol Decanoate", "Haloperidol Decanoate", "Haloperidol Decanoate", "Haloperidol decanoate", "Haloperidol decanoate", "Haloperidol decanoate", "Haloperidol decanoate", "Haloperidol decanoate", "Haloperidol decanoate", "Haloperidol decanoate", "Haloperidol decanoate", "Haloperidol Decanoate", "Haloperidol Decanoate", "Haloperidol Decanoate", "Haloperidol Decanoate", "Haloperidol Decanoate", "Haloperidol Decanoate", "Haloperidol Decanoate", "Haloperidol Decanoate", "Haloperidol Decanoate", "Haloperidol Decanoate", "Haloperidol Decanoate", "Haloperidol Decanoate", "Haloperidol Decanoate", "Haloperidol Decanoate", "Haloperidol Decanoate", "Haloperidol Decanoate", "Haloperidol Decanoate", "Haloperidol Decanoate", "Haloperidol Decanoate", "Haloperidol Decanoate", "Haloperidol Decanoate", "Haloperidol Decanoate", "Haloperidol Decanoate", "Haloperidol Decanoate", "Haloperidol Decanoate", "Haloperidol Decanoate", "Haloperidol Decanoate", "Haloperidol Decanoate", "Haloperidol Decanoate", "Haloperidol decanoate", "Haloperidol decanoate", "Haloperidol decanoate", "Haloperidol decanoate", "Haloperidol Decanoate", "Haloperidol Decanoate", "Haloperidol Decanoate Inj. Liq Im 100mg/ml", "Haloperidol Decanoate Inj. Liq Im 50mg/ml", "Haloperidol Decanoate Injection", "Haloperidol Decanoate Injection", "Haloperidol Decanoate Injection", "Haloperidol Decanoate Injection", "Haloperidol Inj 5mg/ml USP", "Haloperidol Injection", "Haloperidol Injection", "Haloperidol Injection", "Haloperidol Injection, USP", "Haloperidol LA", "Haloperidol LA", "Haloperidol Lactate", "Haloperidol Lactate", "Haloperidol Lactate", "Haloperidol Lactate", "Haloperidol Lactate", "Haloperidol Long Acting", "Haloperidol Long Acting", "Haloperidol Tab 0.5mg", "Haloperidol Tab 1mg", "Haloperidol Tab 2mg", "Haloperidol Tab 5mg", "Haloperidol-10 Tab 10mg", "Haloperidol-LA Omega", "Haloperidol-LA Omega", "Novo-peridol Oral Soln 2mg/ml", "Nu-haloperidol", "Nu-haloperidol", "Nu-haloperidol", "Nu-haloperidol", "Nu-haloperidol", "PMS-haloperidol Soln 2mg/ml", "PMS-haloperidol-LA", "PMS-haloperidol-LA", "Ratio-haloperidol 2mg/ml", "Ratio-haloperidol Tab 0.5mg", "Ratio-haloperidol Tab 10mg", "Ratio-haloperidol Tab 1mg", "Ratio-haloperidol Tab 2mg", "Ratio-haloperidol Tab 5mg", "Rho-haloperidol Decanoate Inj.-im 100mg/ml", "Rho-haloperidol Decanoate Inj.-im 50mg/ml", "Teva-haloperidol", "Teva-haloperidol", "Teva-haloperidol", "Teva-haloperidol", "Teva-haloperidol", "Teva-haloperidol", "Truemed Group LLC" ]	[ "Aloperidin", "Bioperidolo", "Brotopon", "Dozic", "Duraperidol", "Einalon S", "Eukystol", "Halosten", "Keselan", "Linton", "Peluces", "Serenace", "Sigaperidol" ]	[]	[ "P28335", "P14416", "P28223", "P35462", "Q99705", "Q05940", "Q99720", "P35367", "P20309", "P35348", "P08913", "P18089", "P18825", "P08908", "P50406", "P34969", "Q13224", "P21728" ]	[ "P16152", "O60656", "P33261", "P11712", "P04798", "P05177", "P10635", "P20815", "P08684", "P24462" ]	[]	[ "P08183" ]
DB00503	Ritonavir	Ritonavir is an HIV protease inhibitor that interferes with the reproductive cycle of HIV. Although it was initially developed as an independent antiviral agent, it has been shown to possess advantageous properties in combination regimens with low-dose ritonavir and other protease inhibitors. It is now more commonly used as a booster of other protease inhibitors and is available in both liquid formulations and as capsules. While ritonavir is not an active antiviral agent against hepatitis C virus (HCV) infection, it is added in combination therapies indicated for the treatment of HCV infections as a booster. Ritonavir is a potent CYP3A inhibitor that increases peak and trough plasma drug concentrations of other protease inhibitors such as [DB09297] and overall drug exposure. American Association for the Study of Liver Diseases (AASLD) and the Infectious Diseases Society of America (IDSA) guidelines recommend ritonavir-boosted combination therapies as first-line therapy for HCV Genotype 1a/b and 4 treatment-naïve patients with or without cirrhosis. Ritonavir is found in a fixed-dose combination product with [DB09296], [DB09183], and [DB09297] as the FDA-approved product Viekira Pak. First approved in December 2014, Viekira Pak is indicated for the treatment of HCV genotype 1b without cirrhosis or with compensated cirrhosis, and when combined with Ribavirin for the treatment of HCV genotype 1a without cirrhosis or with compensated cirrhosis. Ritonavir is also available as a fixed-dose combination product with [DB09296] and [DB09297] as the FDA- and Health Canada-approved product Technivie. First approved in July 2015, Technivie is indicated in combination with Ribavirin for the treatment of patients with genotype 4 chronic hepatitis C virus (HCV) infection without cirrhosis or with compensated cirrhosis. In Canada, ritonavir is also available as a fixed-dose combination product with [DB09296], [DB09183], and [DB09297] as the Health Canada-approved, commercially available product Holkira Pak. First approved in January 2015, Holkira Pak is indicated for the treatment of HCV genotype 1b with or without cirrhosis, and when combined with Ribavirin for the treatment of HCV genotype 1a with or without cirrhosis. The inclusion of ritonavir can select for HIV-1 protease inhibitor resistance-associated substitutions. Any HCV/HIV-1 co-infected patients treated with ritonavir-containing combination therapies should also be on a suppressive antiretroviral drug regimen to reduce the risk of HIV-1 protease inhibitor drug resistance. Ritonavir is combined with other drugs to treat coronavirus disease 2019 (COVID-19) in patients at risk for progressing into a severe form of the disease, such as [nirmatrelvir].[L40094]	solid	Ritonavir is indicated in combination with other antiretroviral agents for the treatment of HIV-1 infection.[L3513, L12357, L11163, L13443] In the US, Europe, and Canada, ritonavir, in combination with [nirmatrelvir], is indicated for the treatment of mild-to-moderate coronavirus disease 2019 (COVID-19) in adults who are at high risk for progression to severe COVID-19, including hospitalization or death.[L46586, L39840] In Europe, this therapeutic indication is approved under conditional marketing authorization.[L40089]	Ritonavir is a protease inhibitor with activity against Human Immunodeficiency Virus Type 1 (HIV-1). Protease inhibitors block the part of HIV called protease. HIV-1 protease is an enzyme required for the proteolytic cleavage of the viral polyprotein precursors into the individual functional proteins found in infectious HIV-1. Ritonavir binds to the protease active site and inhibits the activity of the enzyme. This inhibition prevents cleavage of the viral polyproteins resulting in the formation of immature non-infectious viral particles. Protease inhibitors are almost always used in combination with at least two other anti-HIV drugs. Modern protease inhibitors require the use of low-dose ritonavir to boost pharmacokinetic exposure through inhibition of metabolism via the cytochrome P450 3A4 enzyme pathway.	Ritonavic inhibits the HIV viral proteinase enzyme that normally cleaves the structural and replicative proteins that arise from major HIV genes, such as gag and pol. Gag encodes proteins involved in the core and the nucleocapsid, while pol encodes the the HIV reverse transcriptase, ribonuclease H, integrase, and protease [A19647]. The pol-encoded proteins are initially translated in the form of a larger precursoe polypeptide, gag-pol, and needs to be cleaved by HIV protease to form other complement proteins [A19647]. Ritonavir prevents the cleavage of the gag-pol polyprotein, which results in noninfectious, immature viral particles. Ritonavir is a potent inhibitor of cytochrome P450 CYP3A4 isoenzyme present both in the intestinal tract and liver [A19647]. It is a type II ligand that perfectly fits into the CYP3A4 active site cavity and irreversibly binds to the heme iron via the thiazole nitrogen, which decreases the redox potential of the protein and precludes its reduction with the redox partner, cytochrome P450 reductase [A19648]. Ritonavir may also play a role in limiting cellular transport and efflux of other protease inhibitors via the P-glycoprotein and MRP efflux channels [A19647].	The absolute bioavailability of ritonavir has not been determined.[L3513] Following oral administration, peak concentrations are reached after approximately 2 hours and 4 hours (T<sub>max</sub>) after dosing under fasting and non-fasting conditions, respectively.[L3513] It should be noted that ritonavir capsules and tablets are not considered bioequivalent.[L3513]	Ritonavir circulates in the plasma predominantly as unchanged drug. Five metabolites have been identified.[L3513] The isopropylthiazole oxidation metabolite (M-2) is the major metabolite in low plasma concentrations and retains similar antiviral activity to unchanged ritonavir. The cytochrome P450 enzymes CYP3A and CYP2D6 are the enzymes primarily involved in the metabolism of ritonavir.[L3513]	Human experience of acute overdose with ritonavir is limited. One patient in clinical trials took ritonavir 1500 mg/day for two days. The patient reported paresthesias which resolved after the dose was decreased. A post-marketing case of renal failure with eosinophilia has been reported with ritonavir overdose. The approximate lethal dose was found to be greater than 20 times the related human dose in rats and 10 times the related human dose in mice. Oral LD value in rats is >2500 mg/kg. Adverse effects of ritonavir may arise from drug-drug interactions. Other effects include hepatotoxicity, pancreatitis, and allergic reactions/hypersensitivity.	The approximate half-life of ritonavir is 3-5 hours.[L3513]	Ritonavir is highly protein-bound in plasma (~98-99%), primarily to albumin and alpha-1 acid glycoprotein over the standard concentration range.[L3513]	Ritonavir is primarily eliminated in the feces.[L3513] Following oral administration of a single 600mg dose of radiolabeled ritonavir, approximately 11.3 ± 2.8% of the dose was excreted into the urine, of which 3.5 ± 1.8% was unchanged parent drug.[L3513] The same study found that 86.4 ± 2.9% of the dose was excreted in the feces, of which 33.8 ± 10.8% was unchanged parent drug.[L3513]	The estimated volume of distribution of ritonavir is 0.41 ± 0.25 L/kg.[L3513]	The apparent oral clearance at steady-state is 8.8 ± 3.2 L/h.[L3513] Renal clearance is minimal and estimated to be <0.1 L/h.[L3513]	Organic compounds	Organic acids and derivatives	Carboxylic acids and derivatives	Amino acids, peptides, and analogues	[ "approved", "investigational" ]	[ "J05AP", "J05A", "J05", "J", "J05AR", "J05A", "J05", "J", "J05AE", "J05A", "J05", "J", "J05AE", "J05A", "J05", "J", "J05AR", "J05A", "J05", "J", "J05AR", "J05A", "J05", "J", "J05AP", "J05A", "J05", "J" ]	[ "Human Immunodeficiency Virus", "SARS-CoV-2" ]	[ { "cost": "10.29", "description": "Norvir 100 mg softgel cap", "unit": "softgel capsule" }, { "cost": "10.29", "description": "Norvir 100 mg tablet", "unit": "tablet" } ]	[ { "approved": "1996-07-30", "country": "United States", "expires": "2013-07-30", "number": "5541206" }, { "approved": "2006-04-11", "country": "Canada", "expires": "2015-01-03", "number": "2178632" }, { "approved": "1996-08-27", "country": "Canada", "expires": "2013-12-16", "number": "2135890" }, { "approved": "2004-03-09", "country": "United States", "expires": "2016-12-26", "number": "6703403" }, { "approved": "2000-03-14", "country": "United States", "expires": "2016-12-26", "number": "6037157" }, { "approved": "2001-05-15", "country": "United States", "expires": "2018-05-07", "number": "6232333" }, { "approved": "2008-10-07", "country": "United States", "expires": "2020-11-22", "number": "7432294" }, { "approved": "2006-11-28", "country": "United States", "expires": "2020-11-22", "number": "7141593" }, { "approved": "1999-06-22", "country": "United States", "expires": "2016-06-13", "number": "5914332" }, { "approved": "2001-09-04", "country": "United States", "expires": "2016-08-15", "number": "6284767" }, { "approved": "2008-04-29", "country": "United States", "expires": "2021-05-10", "number": "7364752" }, { "approved": "2012-11-13", "country": "United States", "expires": "2025-06-24", "number": "8309613" }, { "approved": "2013-02-19", "country": "United States", "expires": "2028-04-22", "number": "8377952" }, { "approved": "2014-04-08", "country": "United States", "expires": "2025-02-25", "number": "8691878" }, { "approved": "2011-09-27", "country": "United States", "expires": "2028-06-14", "number": "8025899" }, { "approved": "2006-12-12", "country": "United States", "expires": "2020-01-19", "number": "7148359" }, { "approved": "2013-06-25", "country": "United States", "expires": "2027-03-17", "number": "8470347" }, { "approved": "2012-09-18", "country": "United States", "expires": "2025-02-25", "number": "8268349" }, { "approved": "2013-03-19", "country": "United States", "expires": "2025-02-25", "number": "8399015" }, { "approved": "2002-10-01", "country": "United States", "expires": "2018-05-07", "number": "6458818" }, { "approved": "2003-02-18", "country": "United States", "expires": "2018-05-07", "number": "6521651" }, { "approved": "2005-06-28", "country": "United States", "expires": "2022-05-28", "number": "6911214" }, { "approved": "2013-08-06", "country": "United States", "expires": "2021-11-28", "number": "8501219" }, { "approved": "2015-09-22", "country": "United States", "expires": "2028-11-09", "number": "9139536" }, { "approved": "2014-04-01", "country": "United States", "expires": "2032-09-04", "number": "8685984" }, { "approved": "2013-06-18", "country": "United States", "expires": "2032-09-04", "number": "8466159" }, { "approved": "2014-02-04", "country": "United States", "expires": "2029-09-10", "number": "8642538" }, { "approved": "2013-08-06", "country": "United States", "expires": "2028-09-17", "number": "8501238" }, { "approved": "2014-03-25", "country": "United States", "expires": "2032-09-04", "number": "8680106" }, { "approved": "2013-07-23", "country": "United States", "expires": "2032-09-04", "number": "8492386" }, { "approved": "2012-05-29", "country": "United States", "expires": "2029-05-17", "number": "8188104" }, { "approved": "2015-04-14", "country": "United States", "expires": "2030-06-10", "number": "9006387" }, { "approved": "2015-06-02", "country": "United States", "expires": "2031-04-10", "number": "9044480" }, { "approved": "2014-04-01", "country": "United States", "expires": "2031-06-09", "number": "8686026" }, { "approved": "2013-04-16", "country": "United States", "expires": "2031-10-10", "number": "8420596" }, { "approved": "2014-04-08", "country": "United States", "expires": "2032-04-13", "number": "8691938" }, { "approved": "2017-04-25", "country": "United States", "expires": "2033-10-18", "number": "9629841" }, { "approved": "2016-05-10", "country": "United States", "expires": "2035-01-02", "number": "9333204" }, { "approved": "2017-08-29", "country": "United States", "expires": "2035-01-02", "number": "9744170" }, { "approved": "2018-10-23", "country": "United States", "expires": "2035-01-02", "number": "10105365" }, { "approved": "2019-02-12", "country": "United States", "expires": "2032-05-17", "number": "10201584" }, { "approved": "2019-02-12", "country": "United States", "expires": "2033-10-18", "number": "10201542" }, { "approved": "2019-02-12", "country": "United States", "expires": "2032-05-17", "number": "10201541" }, { "approved": "2021-08-05", "country": "United States", "expires": "2041-08-05", "number": "11351149" }, { "approved": "2021-10-31", "country": "United States", "expires": "2041-10-31", "number": "11541034" } ]	Ritonavir \| Ritonavirum \| Pr160Gag-Pol \| Orphan nuclear receptor PAR1 \| Orphan nuclear receptor PXR \| Pregnane X receptor \| PXR \| Steroid and xenobiotic receptor \| SXR \| 1,4-cineole 2-exo-monooxygenase \| 1,8-cineole 2-exo-monooxygenase \| 1.14.14.1 \| Albendazole monooxygenase (sulfoxide-forming) \| Albendazole sulfoxidase \| Cholesterol 25-hydroxylase \| CYP3A3 \| CYPIIIA3 \| CYPIIIA4 \| Cytochrome P450 3A3 \| Cytochrome P450 HLp \| Cytochrome P450 NF-25 \| Cytochrome P450-PCN1 \| Nifedipine oxidase \| Quinine 3-monooxygenase \| 1.14.14.- \| Cholesterol 25-hydroxylase \| CYP2DL1 \| CYPIID6 \| Cytochrome P450-DB1 \| Debrisoquine 4-hydroxylase \| (R)-limonene 6-monooxygenase \| (S)-limonene 6-monooxygenase \| (S)-limonene 7-monooxygenase \| 1.14.14.1 \| Cholesterol 25-hydroxylase \| CYP2C10 \| CYPIIC9 \| Cytochrome P-450MP \| Cytochrome P450 MP-4 \| Cytochrome P450 MP-8 \| Cytochrome P450 PB-1 \| S-mephenytoin 4-hydroxylase \| (R)-limonene 6-monooxygenase \| (S)-limonene 6-monooxygenase \| (S)-limonene 7-monooxygenase \| 1.14.14.1 \| CYPIIC17 \| CYPIIC19 \| Cytochrome P450-11A \| Cytochrome P450-254C \| Fenbendazole monooxygenase (4'-hydroxylating) \| Mephenytoin 4-hydroxylase \| 1,4-cineole 2-exo-monooxygenase \| 1.14.13.- \| CYPIIB6 \| Cytochrome P450 IIB1 \| 1.14.14.1 \| CYPIIC8 \| Cytochrome P450 form 1 \| Cytochrome P450 IIC2 \| Cytochrome P450 MP-12 \| Cytochrome P450 MP-20 \| S-mephenytoin 4-hydroxylase \| 1.14.14.1 \| Cholesterol 25-hydroxylase \| CYPIA2 \| Cytochrome P(3)450 \| Cytochrome P450 4 \| Cytochrome P450-P3 \| Hydroperoxy icosatetraenoate dehydratase \| 1.14.14.1 \| CYPIIIA5 \| Cytochrome P450-PCN3 \| 1.14.14.1 \| CYPIIIA7 \| Cytochrome P450-HFLA \| P450HLp2 \| 2.4.1.17 \| GNT1 \| Phenol-metabolizing UDP-glucuronosyltransferase \| UDP-glucuronosyltransferase 1-F \| UDP-glucuronosyltransferase 1A6 \| UDPGT 1-6 \| UGT-1F \| UGT1 \| UGT1-06 \| UGT1.6 \| UGT16 \| UGT1F \| 2.4.1.17 \| Bilirubin-specific UDPGT isozyme 1 \| GNT1 \| hUG-BR1 \| UDP-glucuronosyltransferase 1-1 \| UDP-glucuronosyltransferase 1A isoform 1 \| UDPGT 1-1 \| UGT1 \| UGT1-01 \| UGT1.1 \| UGT11 \| UGT1A1 \| 2.4.1.17 \| GNT1 \| UDP-glucuronosyltransferase 1-10 \| UDP-glucuronosyltransferase 1-J \| UDPGT 1-10 \| UGT-1J \| UGT1 \| UGT1-10 \| UGT1.10 \| UGT110 \| UGT1A10 \| UGT1J \| 2.4.1.17 \| GNT1 \| UDP-glucuronosyltransferase 1-3 \| UDP-glucuronosyltransferase 1-C \| UDP-glucuronosyltransferase 1A isoform 3 \| UDPGT 1-3 \| UGT-1C \| UGT1 \| UGT1-03 \| UGT1.3 \| UGT13 \| UGT1A3 \| UGT1C \| 2.4.1.17 \| Bilirubin-specific UDPGT isozyme 2 \| GNT1 \| hUG-BR2 \| UDP-glucuronosyltransferase 1-4 \| UDP-glucuronosyltransferase 1-D \| UDPGT 1-4 \| UGT-1D \| UGT1 \| UGT1-04 \| UGT1.4 \| UGT14 \| UGT1A4 \| UGT1D \| 2.4.1.17 \| GNT1 \| UDP-glucuronosyltransferase 1-7 \| UDP-glucuronosyltransferase 1-G \| UDPGT 1-7 \| UGT-1G \| UGT1 \| UGT1-07 \| UGT1.7 \| UGT17 \| UGT1A7 \| UGT1G \| 2.4.1.17 \| GNT1 \| UDP-glucuronosyltransferase 1-8 \| UDP-glucuronosyltransferase 1-H \| UDPGT 1-8 \| UGT-1H \| UGT1 \| UGT1-08 \| UGT1.8 \| UGT18 \| UGT1A8 \| UGT1H \| 2.4.1.17 \| GNT1 \| lugP4 \| UDP-glucuronosyltransferase 1-9 \| UDP-glucuronosyltransferase 1-I \| UDPGT 1-9 \| UGT-1I \| UGT1 \| UGT1-09 \| UGT1.9 \| UGT19 \| UGT1A9 \| UGT1I \| 2.4.1.17 \| HLUG4 \| UDP-glucuronosyltransferase 2B8 \| UDPGT 2B15 \| UDPGT 2B8 \| UDPGTh-3 \| UGT2B15 \| UGT2B8 \| 2.4.1.17 \| HLUG25 \| Hyodeoxycholic acid-specific UDPGT \| UDPGT 2B4 \| UDPGTh-1 \| UGT2B11 \| UGT2B4 \| 2.4.1.17 \| 3,4-catechol estrogen-specific UDPGT \| UDP-glucuronosyltransferase 2B9 \| UDPGT 2B7 \| UDPGT 2B9 \| UDPGTh-2 \| UGT2B7 \| UGTB2B9 \| AGP 1 \| AGP1 \| OMD 1 \| Orosomucoid-1 \| ATP-binding cassette sub-family B member 1 \| MDR1 \| Multidrug resistance protein 1 \| P-glycoprotein 1 \| PGY1 \| Phospholipid transporter ABCB1 \| 7.6.2.2 \| ATP-binding cassette sub-family C member 1 \| Glutathione-S-conjugate-translocating ATPase ABCC1 \| Leukotriene C(4) transporter \| LTC4 transporter \| MRP \| MRP1 \| OATP \| OATP-1 \| OATP-A \| OATP1 \| OATP1A2 \| Organic anion-transporting polypeptide 1 \| SLC21A3 \| Sodium-independent organic anion transporter \| Solute carrier family 21 member 3 \| 7.6.2.- \| 7.6.2.2 \| 7.6.2.3 \| Canalicular multidrug resistance protein \| Canalicular multispecific organic anion transporter 1 \| CMOAT \| CMOAT1 \| CMRP \| MRP2 \| Multidrug resistance-associated protein 2 \| 7.6.2.2 \| ABCP \| ATP-binding cassette sub-family G member 2 \| BCRP \| BCRP1 \| Breast cancer resistance protein \| CDw338 \| Mitoxantrone resistance-associated protein \| MXR \| Placenta-specific ATP-binding cassette transporter \| Urate exporter \| Liver-specific organic anion transporter 1 \| LST-1 \| LST1 \| OATP-2 \| OATP-C \| OATP1B1 \| OATP2 \| OATPC \| Organic anion transporter SLC21A6 \| SLC21A6 \| SLCO1B1 \| Sodium-independent organic anion-transporting polypeptide 2 \| Solute carrier family 21 member 6 \| KIAA0880 \| OATP-B \| OATP-RP2 \| OATP2B1 \| OATPB \| OATPRP2 \| Organic anion transporter B \| Organic anion transporter polypeptide-related protein 2 \| Organic anion transporting polypeptide 2B1 \| SLC21A9 \| Solute carrier family 21 member 9 \| 7.6.2.- \| ATP-binding cassette sub-family B member 11 \| BSEP \| Liver-specific organic anion transporter 2 \| LST-2 \| LST2 \| OATP-8 \| OATP1B3 \| OATP8 \| Organic anion transporter 8 \| Organic anion-transporting polypeptide 8 \| SLC21A8 \| Solute carrier family 21 member 8	[ "Auro-ritonavir", "Holkira Pak", "Kaletra", "Kaletra", "Kaletra", "Kaletra", "Kaletra", "Kaletra", "Kaletra", "Kaletra", "Kaletra", "Kaletra", "Kaletra", "Kaletra", "Kaletra", "Kaletra", "Kaletra", "Kaletra", "Kaletra", "Kaletra", "Kaletra", "Kaletra", "Kaletra", "Kaletra", "Kaletra", "Kaletra", "Kaletra", "Kaletra", "Kaletra", "Kaletra", "Kaletra", "Kaletra", "Kaletra", "Kaletra", "Lopinavir and Ritonavir", "Lopinavir and ritonavir", "Lopinavir and ritonavir", "Lopinavir and Ritonavir", "Lopinavir and Ritonavir", "Lopinavir and Ritonavir", "Lopinavir and Ritonavir", "Lopinavir and Ritonavir", "Lopinavir-Ritonavir", "Lopinavir/ritonavir Mylan", "Lopinavir/ritonavir Mylan", "Lopinavir/ritonavir Mylan", "Lopinavir/ritonavir Mylan", "Lopinavir/ritonavir Mylan", "Lopinavir/ritonavir Mylan", "Lopinavir/ritonavir Mylan", "Lopinavir/ritonavir Mylan", "Norvir", "Norvir", "Norvir", "Norvir", "Norvir", "Norvir", "Norvir", "Norvir", "Norvir", "Norvir", "Norvir", "Norvir", "Norvir", "Norvir", "Norvir", "Norvir", "Norvir", "Norvir", "Norvir", "Norvir Sec", "Paxlovid", "Paxlovid", "Paxlovid", "Paxlovid", "Paxlovid", "Paxlovid", "Paxlovid", "Paxlovid", "Paxlovid", "Paxlovid", "Paxlovid", "Ritonavir", "Ritonavir", "Ritonavir", "Ritonavir", "Ritonavir", "Ritonavir", "Ritonavir", "Ritonavir", "Ritonavir", "Ritonavir", "Ritonavir", "Ritonavir film coated", "Ritonavir Mylan", "Ritonavir Mylan", "Ritonavir Mylan", "Ritonavir Mylan", "Ritonavir Mylan", "Ritonavir Mylan", "Ritonavir Mylan", "Ritonavir Mylan", "Technivie", "Technivie", "Viekira Pak", "Viekira XR", "Viekirax" ]	[ "Busvir", "Empetus", "Normune" ]	[ "Kaletra", "Kaletra", "Kaletra", "Kaletra", "Kaletra", "Kaletra", "Kaletra", "Kaletra", "Kaletra", "Lopinavir and Ritonavir", "Viekira Pak", "Lopinavir-Ritonavir", "Kaletra", "Kaletra", "Kaletra", "Kaletra", "Kaletra", "Kaletra", "Viekira XR", "Kaletra", "Kaletra", "Technivie", "Kaletra", "Kaletra", "Lopinavir and ritonavir", "Lopinavir and ritonavir", "Technivie", "Kaletra", "Kaletra", "Kaletra", "Kaletra", "Holkira Pak", "Paxlovid", "Paxlovid", "Lopinavir and Ritonavir", "Lopinavir and Ritonavir", "Paxlovid", "Paxlovid", "Paxlovid", "Lopinavir and Ritonavir", "Kaletra", "Kaletra", "Paxlovid", "Paxlovid", "Paxlovid", "Paxlovid", "Paxlovid", "Lopinavir and Ritonavir", "Lopinavir and Ritonavir", "Viekirax", "Kaletra", "Kaletra", "Kaletra", "Kaletra", "Kaletra", "Kaletra", "Kaletra", "Lopinavir/ritonavir Mylan", "Lopinavir/ritonavir Mylan", "Lopinavir/ritonavir Mylan", "Lopinavir/ritonavir Mylan", "Lopinavir/ritonavir Mylan", "Lopinavir/ritonavir Mylan", "Lopinavir/ritonavir Mylan", "Lopinavir/ritonavir Mylan", "Paxlovid" ]	[ "P03366", "O75469" ]	[ "P08684", "P10635", "P11712", "P33261", "P20813", "P10632", "P05177", "P20815", "P24462", "P19224", "P22309", "Q9HAW8", "P35503", "P22310", "Q9HAW7", "Q9HAW9", "O60656", "P54855", "P06133", "P16662" ]	[ "P02768", "P02763" ]	[ "P08183", "P33527", "P46721", "Q92887", "Q9UNQ0", "Q9Y6L6", "O94956", "O95342", "Q9NPD5" ]
DB00505	Tridihexethyl	Tridihexethyl is a synthetic anticholinergic agent which has been shown in experimental and clinical studies to have a pronounced antispasmodic and antisecretory effect on the gastrointestinal tract. Tridihexethyl is an antimuscarinic, anticholinergic drug. Tridihexethyl is no longer available in the US market.	solid	Used as an adjunct in the treatment of peptic ulcer disease and in Acquired nystagmus	Tridihexethyl is a synthetic anticholinergic agent which has been shown in experimental and clinical studies to have a pronounced antispasmodic and antisecretory effect on the gastrointestinal tract. Tridihexethyl is an antimuscarinic, anticholinergic drug.	Tridihexethyl binds the muscarinic acetylcholine receptor. It may block all three types of muscarinic receptors including M-1 receptors in the CNS and ganglia, M-2 receptors in the heart (vagus) and M-3 receptors at the parasympathetic NEJ system. The muscarinic acetylcholine receptors mediate various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Tridihexethyl inhibits vagally mediated reflexes by antagonizing the action of acetylcholine. This in turn reduces the secretion of gastric acids in the stomach.	null	null	null	null	null	null	null	null	Organic compounds	Organic nitrogen compounds	Organonitrogen compounds	Amines	[ "withdrawn" ]	[ "A03AB", "A03A", "A03", "A" ]	[ "Humans and other mammals" ]	[]	[]		[]	[ "Pathilon", "Propethonum" ]	[]	[ "P08912", "P20309", "P11229", "P08172" ]	[]	[]	[]
DB00507	Nitazoxanide	Nitazoxanide belongs to the class of drugs known as _thiazolides_. Nitazoxanide (NTZ) is a broad-spectrum anti-infective drug that markedly modulates the survival, growth, and proliferation of a range of extracellular and intracellular protozoa, helminths, anaerobic and microaerophilic bacteria, in addition to viruses. This drug is effective in the treatment of gastrointestinal infections including Cryptosporidium parvum or Giardia lamblia in healthy subjects. It is generally well tolerated. Nitazoxanide is a first-line, standard treatment for illness caused by C. parvum or G. lamblia infection in healthy (not immunosuppressed) adults and children and may also be considered in the treatment of illnesses caused by other protozoa or helminths [A31976]. Recently, this drug has been studied as a broad-spectrum antiviral agent due to its ability to inhibit the replication of several RNA and DNA viruses [A31977].	solid	For the treatment of diarrhea in adults and children caused by the protozoa <i>Giardia lamblia</i>, and for the treatment of diarrhea in children caused by the protozoan, <i>Cryptosporidium parvum</i> [FDA label]. Nitazoxanide has not been shown to be superior to placebo medication for the management of diarrhea caused by Cryptosporidium parvum in patients with HIV/immunodeficiency [FDA label, A31973, A31976].	The general effect of this medication is the prevention of microbe activity through disruption of important energy pathways for survival and proliferation [FDA label, A31976]. Nitazoxanide exhibits antiprotozoal activity by interfering with the pyruvate ferredoxin/flavodoxin oxidoreductase dependent electron transfer reaction, an essential reaction need for anaerobic energy metabolism of various microorganisms. Sporozoites of Cryptosporidium parvum and trophozoites of Giardia lamblia are therefore inhibited, relieving symptoms of diahrrea [L1425]. Interference with the PFOR enzyme-dependent electron transfer reaction may only be one of the many pathways by which nitazoxanide exhibits antiprotozoal activity [FDA label, A31973, L1425].	The most widely accepted mechanism of NTZ is believed to be the disruption of the energy metabolism in anaerobic microbes by inhibition of the pyruvate: ferredoxin/flavodoxin oxidoreductase (PFOR) cycle [A31981]. In parasitic-protozoa, Nitazoxanide also induces lesions in the cell membranes and depolarizes the mitochondrial membrane while inhibiting quinone oxidoreductase NQO1, nitroreductase-1 and protein disulphide isomerase enzymes. In addition, this drug also inhibits the glutathione-S-transferase (a major detoxifying enzyme) and modulates the Avr-14 gene, encoding for the alpha-type subunit of glutamate-gated chloride ion channel present in nematodes. Aside from its well understood non-competitive inhibition of the PFOR in anaerobic bacteria, NTZ also demonstrates various other antibacterial mechanisms. It inhibits pyruvate dehydrogenase in E Coli, disrupts the membrane potential and pH homeostasis in the Mycobacterium tuberculosis, suppresses the chaperone/usher (CU) pathway of the gram-negative bacteria, and stimulates host macrophage autophagy in tuberculosis patients [A31976]. NTZ also suppresses viral replication by inhibiting the maturation of the viral hemagglutinin and the viral transcription factor immediate early 2 (IE2) as well as by activating the eukaryotic translation initiation factor 2α (an antiviral intracellular protein). Lastly, NTZ exhibits an inhibitory effect on tumor cell progression by altering drug detoxification (glutathione-S-transferase P1), unfolded protein response, autophagy, anti-cytokines activity, and c-Myc inhibition [A31976].	The relative bioavailability of the suspension compared to the tablet was 70%. When administered with food the AUC and C<sub>max</sub> increased by two-fold and 50%, respectively, for the tablet and 45 to 50% and ≤ 10%, respectively, for the oral suspension [FDA label].	The active metabolite of this drug is tizoxanide (desacetyl-nitazoxanide). The initial reaction in the metabolic pathway of Nitazoxanide is hydrolysis to tizoxanide, followed by conjugation, primarily by glucuronidation to tizoxanide glucuronide. The oral suspension bioavailability of this drug is not equivalent to that of the oral tablets. Compared to the to the tablet, the bioavailability of the suspension was 70% [FDA label]. When administered with food, the AUCt of tizoxanide and tizoxanide glucuronide in plasma is increased to almost two-fold and the maximum concentration is increased by almost 50% compared to when ingested without food [FDA label]. When the oral suspension was ingested with food, the AUC of tizoxanide and tizoxanide glucuronide increased by approximately 50% and the Cmax increased by less than 10% [FDA label].	Data on nitazoxanide overdosage is not available [FDA label]. In studies in rodents and dogs, the oral LD50 was higher than 10,000 mg/kg. One-time oral doses of up to 4000 mg nitazoxanide have been given to healthy adult volunteers without severe adverse effects. Gastric lavage may be appropriate soon after oral administration if overdose occurs. Supportive and symptomatic treatment should also be administered [FDA label]. According to previous studies [FDA label], less than 1% of the patients age 12 years and older participating in clinical trials with NTZ suffered from the following adverse effects: Systemic: asthenia, fever, pain, allergic reaction, pelvic pain, back pain, chills, fever, flu-like syndrome. Central Nervous System: dizziness, somnolence, insomnia, tremor, hypesthesia. Gastrointestinal System: vomiting, dyspepsia, anorexia, flatulence, constipation, dry mouth, thirst. Urogenital System: discolored urine, dysuria, amenorrhea, metrorrhagia, kidney pain, edema labia. Metabolic & Nutrition: increased SGPT. Hemic & Lymphatic Systems: anemia, leukocytosis. Skin: rash, pruritus. Special Senses: eye discoloration, ear ache. Respiratory System: epistaxis, lung disease, pharyngitis. Cardiovascular System: tachycardia, syncope, hypertension. Muscular System: myalgia, leg cramps, spontaneous bone fracture.	7.3h [L1422]	Very High (greater than 99%), bound to proteins in the plasma [FDA label, A31981].	Tizoxanide is excreted in the urine, bile and feces, and tizoxanide glucuronide is excreted in urine and bile. Approximately 2/3 of the oral dose of nitazoxanide is excreted in the faeces and 1/3 in the urine [FDA label, A31981].	null	Nitazoxanide is cleared in the urine and feces. The metabolite, tizoxanide, is also found in the urine, plasma, and breastmilk [L1424]. The drug is not found unchanged in the urine [L1424].	Organic compounds	Benzenoids	Benzene and substituted derivatives	Benzoic acids and derivatives	[ "approved", "investigational", "vet_approved" ]	[ "P01AX", "P01A", "P01", "P" ]	[ "Helminthic Microorganisms", "Escherichia coli", "Bacteria and protozoa", "Mycobacterium tuberculosis" ]	[ { "cost": "23.22", "description": "Alinia 500 mg tablet", "unit": "tablet" } ]	[ { "approved": "1995-02-07", "country": "United States", "expires": "2012-02-07", "number": "5387598" }, { "approved": "1999-10-19", "country": "United States", "expires": "2017-05-07", "number": "5968961" }, { "approved": "1999-10-12", "country": "United States", "expires": "2017-07-03", "number": "5965590" }, { "approved": "2000-09-12", "country": "United States", "expires": "2017-05-07", "number": "6117894" } ]	Nitaxozanid \| Nitaxozanide \| Nitazoxanida \| Nitazoxanide \| Nitazoxanidum \| 1.2.7.1 \| POR \| Pyruvate-ferredoxin oxidoreductase.	[ "Alinia", "Alinia", "Alinia", "Alinia", "N/a", "Nitazoxanide" ]	[ "Alpex Nizox", "ANNITA", "Azoxanid", "Celectan", "Colufase", "Coluquim", "Daxon", "Dianide", "Diar", "Famidox", "Kaside", "Kazide", "Larvisol", "Lumbris", "Mixel", "Niazid", "Nitax", "Nitaxide", "Nitazet", "Nitazofin", "Nodik", "Omniparax" ]	[]	[]	[]	[]	[]
DB00508	Triflupromazine	A phenothiazine used as an antipsychotic agent and as an antiemetic.	solid	Used mainly in the management of psychoses. Also used to control nausea and vomiting.	Triflupromazine is a member of a class of drugs called phenthiazines, which are dopamine D1/D2 receptor antagonists. Phenothiazines are used to treat serious mental and emotional disorders, including schizophrenia and other psychotic disorders. It reduces anxiety, emotional withdrawal, hallucinations, disorganized thoughts, blunted mood, and suspiciousness. Triflupromazine is used particularly to control violent behavior during acute episodes of psychotic disorders. It can also be used to control severe nausea and vomiting, severe hiccups, and moderate to severe pain in some hospitalized patients. Triflupromazine acts on the central nervous system.	Triflupromazine binds to the dopamine D1 and dopamine D2 receptors and inhibits their activity. The mechanism of the anti-emetic effect is due predominantly to blockage of the dopamine D2 neurotransmitter receptors in the chemoreceptor trigger zone (CTZ) and vomiting centre. Triflupromazine blocks the neurotransmitter dopamine and the vagus nerve in the gastrointestinal tract. Triflupromazine also binds the muscarinic acetylcholine receptors (M1 and M2) and the tryptamine D receptors (5HT<sub>2B</sub>).	Absorption may be erratic and peak plasma concentrations show large interindividual differences.	Hepatic.	Symptoms of overdose include agitation, coma, convulsions, difficulty breathing, difficulty swallowing, dry mouth, extreme sleepiness, fever, intestinal blockage, irregular heart rate, low blood pressure, and restlessness.	null	Very high (90% or more).	null	null	null	Organic compounds	Organoheterocyclic compounds	Benzothiazines	Phenothiazines	[ "approved", "vet_approved" ]	[ "N05AA", "N05A", "N05", "N" ]	[ "Humans and other mammals" ]	[]	[]	10-(3-(Dimethylamino)propyl)-2-(trifluoromethyl)phenothiazine \| 2-(Trifluoromethyl)promazine \| 2-Trifluoromethyl-10-(gamma-dimethylaminopropyl)phenothiazine \| Fluopromazine \| Triflupromazin \| Triflupromazina \| Triflupromazine \| Triflupromazinum \| Dopamine D2 receptor \| Dopamine D1 receptor \| 5-HT-2B \| 5-HT2B \| Serotonin receptor 2B \| 3.1.1.8 \| Acylcholine acylhydrolase \| Butyrylcholine esterase \| CHE1 \| Choline esterase II \| Pseudocholinesterase \| ATP-binding cassette sub-family B member 1 \| MDR1 \| Multidrug resistance protein 1 \| P-glycoprotein 1 \| PGY1 \| Phospholipid transporter ABCB1	[]	[ "Vesprin" ]	[]	[ "P14416", "P21728", "P41595", "P11229", "P08172" ]	[ "P06276" ]	[]	[ "P08183" ]
DB00509	Dextrothyroxine	The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (monoiodotyrosine) and the coupling of iodotyrosines (diiodotyrosine) in the thyroglobulin. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form triiodothyronine which exerts a broad spectrum of stimulatory effects on cell metabolism.	solid	Used to lower high cholesterol levels in the blood.	Dextrothyroxine, the dextrorotary isomer of the synthetic thyroxine, is a antihyperlipidemic.	Dextrothyroxine is a antihyperlipidemic. The mechanism of action is not completely understood, but dextrothyroxine apparently acts in the liver to stimulate formation of low-density lipoprotein (LDL) and, to a much greater extent, to increase catabolism of LDL. This leads to increased excretion of cholesterol and bile acids via the biliary route into the feces, with a resulting reduction in serum cholesterol and LDL. Dextrothyroxine has no significant effect on high-density lipoproteins (HDL). Inherently, it will also bind to thyroid receptors and as it is a prohormone, it will bind as a substrate to iodide peroxidase.	null	null	Symptoms of dextrothyroxine overdose are unknown.	null	null	null	null	null	Organic compounds	Organic acids and derivatives	Carboxylic acids and derivatives	Amino acids, peptides, and analogues	[ "approved", "investigational" ]	[ "C10AX", "C10A", "C10", "C" ]	[ "Humans and other mammals" ]	[]	[]	D-thyroxine \| Dextrothyroxine \| Dextrothyroxinum \| O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-D-tyrosine \| c-erbA-1 \| c-erbA-alpha \| EAR-7 \| EAR7 \| ERBA1 \| NR1A1 \| Nuclear receptor subfamily 1 group A member 1 \| THRA1 \| THRA2 \| V-erbA-related protein 7 \| c-erbA-2 \| c-erbA-beta \| ERBA2 \| NR1A2 \| Nuclear receptor subfamily 1 group A member 2 \| THR1 \| 1.11.1.8 \| TPO \| Liver-specific organic anion transporter 1 \| LST-1 \| LST1 \| OATP-2 \| OATP-C \| OATP1B1 \| OATP2 \| OATPC \| Organic anion transporter SLC21A6 \| SLC21A6 \| SLCO1B1 \| Sodium-independent organic anion-transporting polypeptide 2 \| Solute carrier family 21 member 6 \| OAT-RP-5 \| OATP-14 \| OATP-F \| OATP-RP5 \| OATP14 \| OATP1C1 \| OATPF \| Organic anion transporter 1C1 \| Organic anion transporter F \| Organic anion transporter polypeptide-related protein 5 \| Organic anion-transporting polypeptide 14 \| SLC21A14 \| Solute carrier family 21 member 14 \| Thyroxine transporter \| Colon organic anion transporter \| OATP-E \| OATP-RP1 \| OATP1 \| OATP4A1 \| OATPE \| OATPRP1 \| Organic anion transporter polypeptide-related protein 1 \| Organic anion-transporting polypeptide E \| POAT \| SLC21A12 \| Sodium-independent organic anion transporter E \| Solute carrier family 21 member 12 \| OATP-H \| OATP-M1 \| OATP4C1 \| OATPX \| Organic anion transporter M1 \| Organic anion transporting polypeptide 4C1 \| SLC21A20 \| SLCO4C1 \| Solute carrier family 21 member 20 \| 4F2 LC \| 4F2 light chain \| 4F2LC \| CD98 light chain \| CD98LC \| E16 \| hLAT1 \| Integral membrane protein E16 \| L-type amino acid transporter 1 \| LAT1 \| MPE16 \| Solute carrier family 7 member 5 \| y+ system cationic amino acid transporter	[ "Choloxin - Tab 4mg", "Choloxin Tab 2mg", "Choloxin Tab 2mg", "Choloxin Tablet 4mg" ]	[ "Choloxin", "Dynothel", "Eulipos", "Lisolipin" ]	[]	[ "P10827", "P10828", "P07202" ]	[]	[]	[ "Q9Y6L6", "Q9NYB5", "Q96BD0", "Q6ZQN7", "Q01650" ]
DB00511	Acetyldigitoxin	Cardioactive derivative of lanatoside A or of digitoxin used for fast digitalization in congestive heart failure.	solid	Used for fast digitalization in congestive heart failure.	The main pharmacological effects of acetyldigitoxin are on the heart. Extracardiac effects are responsible for many of the adverse effects. Its main cardiac effects are 1) a decrease of conduction of electrical impulses through the AV node, making it a commonly used drug in controlling the heart rate during atrial fibrillation or atrial flutter, and 2) an increase of force of contraction via inhibition of the Na<sup>+</sup>/K<sup>+</sup> ATPase pump.	Acetyldigitoxin binds to a site on the extracellular aspect of the α-subunit of the Na<sup>+</sup>/K<sup>+</sup> ATPase pump in the membranes of heart cells (myocytes). This causes an increase in the level of sodium ions in the myocytes, which then leads to a rise in the level of calcium ions. The proposed mechanism is the following: inhibition of the Na<sup>+</sup>/K<sup>+</sup> pump leads to increased Na<sup>+</sup> levels, which in turn slows down the extrusion of Ca<sup>2+</sup> via the Na<sup>+</sup>/Ca<sup>2+</sup> exchange pump. Increased amounts of Ca<sup>2+</sup> are then stored in the sarcoplasmic reticulum and released by each action potential, which is unchanged by acetyldigitoxin. This is a different mechanism from that of catecholamines. Acetyldigitoxin also increases vagal activity via its central action on the central nervous system, thus decreasing the conduction of electrical impulses through the AV node. This is important for its clinical use in different arrhythmias.	Bioavailability is 60 to 80% following oral administration.	null	Toxicity includes ventricular tachycardia or ventricular fibrillation, or progressive bradyarrhythmias, or heart block. LD50 = 7.8 mg/kg (orally in mice).	null	null	null	null	null	Organic compounds	Lipids and lipid-like molecules	Steroids and steroid derivatives	Steroid lactones	[ "approved" ]	[ "C01AA", "C01A", "C01", "C" ]	[ "Humans and other mammals" ]	[]	[]	Acetildigitoxina \| Acetyl-digitoxin-alpha \| Acetyldiginatin \| Acetyldigitoxin \| Acetyldigitoxinum \| Acetylgitoxin \| alpha-Acetyldigitoxin \| alpha-Acetylgitaloxin \| alpha-Monoacetyldigitoxin \| Desglucolanatoside A \| Digitoxin 3'''-acetate \| 7.2.2.13 \| Na(+)/K(+) ATPase alpha-1 subunit \| Sodium pump subunit alpha-1	[]	[]	[]	[ "P05023" ]	[]	[]	[]
DB00512	Vancomycin	Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to ristocetin that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear. As of January 29 2018, CutisPharma's Firvanq is the only FDA approved vancomycin oral liquid treatment option available for the the treatment of _Clostridium difficile_ associated diarrhea and enterocolitis caused by _Staphylococcus aureus_, including methicillin-resistant strains [LP1196]. Such an oral liquid formulation is expected to make _Clostridium difficile_ associated diarrhea therapy more accessible in comparison to previously available specialty compounding products [LP1196].	solid	Administered intravenously, vancomycin is indicated in adult and pediatric patients for the treatment of septicemia, infective endocarditis, skin and skin structure infections, bone infections, and lower respiratory tract infections.[L41529] Administered orally, vancomycin is indicated in adult and pediatric patients for the treatment of _Clostridium difficile_-associated diarrhea and for enterocolitis caused by _Staphylococcus aureus_ (including methicillin-resistant strains).[L41534]	Vancomycin is a branched tricyclic glycosylated nonribosomal peptide often reserved as the "drug of last resort", used only after treatment with other antibiotics has failed. Vancomycin has been shown to be active against most strains of the following microorganisms, both in vitro and in clinical infections: <i>Listeria monocytogenes</i>, <i>Streptococcus pyogenes</i>, <i>Streptococcus pneumoniae</i> (including penicillin-resistant strains), <i>Streptococcus agalactiae</i>, <i>Actinomyces</i> species, and <i>Lactobacillus</i> species. The combination of vancomycin and an aminoglycoside acts synergistically in vitro against many strains of Staphylococcus aureus, Streptococcus bovis, enterococci, and the viridans group streptococci [FDA Label].	The bactericidal action of vancomycin results primarily from inhibition of cell-wall biosynthesis. Specifically, vancomycin prevents incorporation of N-acetylmuramic acid (NAM)- and N-acetylglucosamine (NAG)-peptide subunits from being incorporated into the peptidoglycan matrix, which forms the major structural component of Gram-positive cell walls. Vancomycin forms hydrogen bonds with the terminal D-alanyl-D-alanine moieties of the NAM/NAG-peptides, preventing the incorporation of the NAM/NAG-peptide subunits into the peptidoglycan matrix. In addition, vancomycin alters bacterial-cell-membrane permeability and RNA synthesis. There is no cross-resistance between vancomycin and other antibiotics. Vancomycin is not active in vitro against gram-negative bacilli, mycobacteria, or fungi. [FDA Label]	Poorly absorbed from gastrointestinal tract, however systemic absorption (up to 60%) may occur following intraperitoneal administration [FDA Label].	Since almost 75-80% of the drug is excreted unchanged in the urine after the first 24 hours following administration, there is seemingly no apparent metabolism of the drug [FDA Label, A31723]. The concentration of vancomycin in the liver tissue and bile 24 hours after administration has also been reported at or below detection limits as well [A31723].	The oral LD<sub>50</sub> in mice is 5000 mg/kg. The median lethal intravenous dose is 319 mg/kg in rats and 400 mg/kg in mice. [FDA Label] Conversely, the most common adverse effects associated with vancomycin appear to be nausea, abdominal pain, and hypokalemia [FDA Label]. In particular, incidences of hypokalemia, urinary tracy infection, peripheral edema, insomnia, constipation, anemia, depression, vomiting, and hypotension are higher among subjects >65 years of than in those that are 65 years old or younger [FDA Label]. Additionally, nephrotoxicity involving reports of renal failure, renal impairment, elevated blood creatinine, and others has also occurred with vancomycin therapy during studies, and can occur during or after completion of a course of therapy [FDA Label]. Risk of such nephrotoxicity is increased in patients greater than 65 years of age [FDA Label]. Ototoxicity has also occurred in patients receiving vancomycin treatment, and it can be transient or permanent. This effect has been reported primarily in patients who have been given excessive intravenous doses, who have kidney dysfunction, who have an underlying hearing loss, or who are receiving concomitant therapy with another ototoxic agent like an aminoglycoside [FDA Label]. Potentially related adverse effects like vertigo, dizziness, and tinnitus have also been reported [FDA Label]. Neutropenia, often beginning one week or more after onset of intravenous vancomycin therapy or after a total dose of more than 25 mg has been observed for several dozen patients as well. This neutropenia however, appears to be promptly reversible when the vancomycin treatment is discontinued. Alternatively, thrombocytopenia has also been reported [FDA Label]. Additionally, a condition has been reported that is described as being similar to IV-induced symptoms involving symptoms consistent with anaphylactoid reactions, including hypotension, wheezing, dyspnea, urticaria, pruritus, flushing of the upper body (in what is known as the so-called 'Red Man Syndrome'), pain and muscle spasm of the chest and back. Although on average such reactions usually resolve within 20 minutes, they are just as likely to persist for hours [FDA Label, A760]. In a controlled clinical study, the potential ototoxic and nephrotoxic effects of vancomycin on infants were assessed when the drug was given intravenously to pregnant women for serious staphylococcal infections complicating intravenous drug abuse. The results obtained demonstrated that vancomycin was found in cord blood but that no sensorineural hearing loss or nephrotoxicity attributable to vancomycin was noted. Ultimately however, because the number of subjects treated in this study was limited and vancomycin was administered only in the second and third trimesters, it is not formally known whether vancomycin causes fetal harm. Subsequently, vancomycin should be given to a pregnant woman only if clearly needed [FDA Label]. Although it is known that vancomycin is excreted in human milk based on information obtained from the intravenous administration of the medication, it is not known if vancomycin is excreted into human milk after oral administration. However, because of the overall potential for adverse events, caution must be exercised when vancomycin is given to a nursing woman and a decision must be made whether to discontinue nursing or discontinue the drug, taking into consideration the importance of the drug to the mother [FDA Label]. The safety and effectiveness in pediatric patients have not been formally established [FDA Label]. Patients older than 65 years of age may take longer to respond to therapy compared to patients aged 65 year or younger. Vancomycin treatment in patients aged older than 65 years subsequently should not be discontinued or switched to an alternative treatment prematurely [FDA Label]. Furthermore, clinical studies have demonstrated that geriatric patients are at increased risk of developing nephrotoxicity following treatment with oral vancomycin, which can occur during or after completion of therapy. In patients aged older than 65 years, including those with normal renal function prior to treatment, renal function should be monitored during and following treatment with vancomycin to detect any potential vancomycin induced nephrotoxicity [FDA Label].	Half-life in normal renal patients is approximately 6 hours (range 4 to 11 hours). In anephric patients, the average half-life of elimination is 7.5 days [FDA Label].	Approximately 50% serum protein bound [A31722].	In the first 24 hours, about 75-80% of an administered dose of vancomycin is excreted in urine by glomerular filtration [FDA Label, A31723].	The volume of distribution, as discussed in the literature, varies between 0.4-1 L/kg [A31720].	The mean plasma clearance of vancomycin is about 0.058 L/kg/h [FDA Label].	Organic compounds	Organic acids and derivatives	Carboxylic acids and derivatives	Amino acids, peptides, and analogues	[ "approved" ]	[ "J01XA", "J01X", "J01", "J", "A07AA", "A07A", "A07", "A", "S01AA", "S01A", "S01", "S" ]	[ "Enteric bacteria and other eubacteria", "Treponema pallidum", "Streptococcus pyogenes", "Neisseria gonorrhoeae", "Mycoplasma pneumoniae", "Legionella pneumophila", "Corynebacterium diphtheriae", "Chlamydia psittaci", "Chlamydia trachomatis", "Chlamydia pneumoniae", "Bordetella pertussis" ]	[ { "cost": "3.74", "description": "Vancomycin 500 mg vial", "unit": "vial" }, { "cost": "5.72", "description": "Vancomycin hcl 750 mg vial", "unit": "vial" }, { "cost": "7.0", "description": "Vancomycin 1 gm vial", "unit": "vial" }, { "cost": "22.22", "description": "Vancocin hcl 125 mg pulvule", "unit": "each" }, { "cost": "27.66", "description": "Vancocin HCl 125 mg capsule", "unit": "capsule" }, { "cost": "32.62", "description": "Pms-Vancomycin 500 mg/vial", "unit": "vial" }, { "cost": "40.97", "description": "Vancocin hcl 250 mg pulvule", "unit": "each" }, { "cost": "61.98", "description": "Pms-Vancomycin 1 g/vial", "unit": "vial" }, { "cost": "85.68", "description": "Vancomycin hcl powder", "unit": "g" }, { "cost": "1019.87", "description": "Vancocin HCl 20 250 mg capsule Box", "unit": "box" }, { "cost": "0.17", "description": "Vancomycin hcl 1 g/200 ml bag", "unit": "ml" }, { "cost": "0.21", "description": "Vancomycin-ns 1.25 g/150 ml", "unit": "ml" }, { "cost": "0.24", "description": "Vancomycin-ns 1.5 g/150 ml", "unit": "ml" } ]	[ { "approved": "2019-01-29", "country": "United States", "expires": "2035-11-06", "number": "10188697" }, { "approved": "2018-08-07", "country": "United States", "expires": "2035-11-06", "number": "10039804" }, { "approved": "2019-12-03", "country": "United States", "expires": "2035-03-13", "number": "10493028" }, { "approved": "2020-06-23", "country": "United States", "expires": "2035-03-13", "number": "10688046" }, { "approved": "2020-12-01", "country": "United States", "expires": "2035-11-06", "number": "10849956" }, { "approved": "2021-03-30", "country": "United States", "expires": "2035-03-13", "number": "10959947" }, { "approved": "2021-03-30", "country": "United States", "expires": "2035-03-13", "number": "10959948" }, { "approved": "2021-03-30", "country": "United States", "expires": "2035-03-13", "number": "10959949" }, { "approved": "2021-03-30", "country": "United States", "expires": "2035-03-13", "number": "10959946" }, { "approved": "2021-05-11", "country": "United States", "expires": "2035-11-06", "number": "11000567" }, { "approved": "2015-11-06", "country": "United States", "expires": "2035-11-06", "number": "11517609" }, { "approved": "2015-11-06", "country": "United States", "expires": "2035-11-06", "number": "11628200" }, { "approved": "2015-03-13", "country": "United States", "expires": "2035-03-13", "number": "11638692" } ]	Vancomicina \| Vancomycin \| Vancomycine \| Vancomycinum \| AGP 1 \| AGP1 \| OMD 1 \| Orosomucoid-1 \| AGP 2 \| AGP2 \| OMD 2 \| Orosomucoid-2 \| Bphs \| H1R	[ "Firvanq", "Firvanq", "Firvanq", "Firvanq", "Firvanq", "Firvanq", "Firvanq", "Firvanq", "Jamp Vancomycin", "Jamp Vancomycin", "Jamp-vancomycin", "Jamp-vancomycin", "PMS-vancomycin", "PMS-vancomycin", "PMS-vancomycin 1 G", "PMS-vancomycin 500 mg", "Pmsc-vancomycin", "Pmsc-vancomycin", "Sterile Vancomycin HCl 5.0gm/vial", "Sterile Vancomycin HCl USP 1.0gm/vial", "Sterile Vancomycin HCl USP 500mg/vial", "Sterile Vancomycin Hydrochloride", "Sterile Vancomycin Hydrochloride", "Sterile Vancomycin Hydrochloride", "Sterile Vancomycin Hydrochloride", "Sterile Vancomycin Hydrochloride", "Sterile Vancomycin Hydrochloride, USP", "Sterile Vancomycin Hydrochloride, USP", "Vancocin", "Vancocin", "Vancocin", "Vancocin", "Vancocin", "Vancocin", "Vancocin", "Vancocin", "Vancocin Cp Add-vantage Inj 500mg/vial", "Vancocin Inj 1gm/vial Advantage", "Vancomycin", "Vancomycin", "Vancomycin", "Vancomycin", "Vancomycin", "Vancomycin", "Vancomycin", "Vancomycin", "Vancomycin", "Vancomycin", "Vancomycin HCl", "Vancomycin HCl", "Vancomycin HCl", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin hydrochloride", "Vancomycin hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride Capsules, USP", "Vancomycin Hydrochloride Capsules, USP", "Vancomycin Hydrochloride for Injection", "Vancomycin Hydrochloride for Injection", "Vancomycin Hydrochloride for Injection", "Vancomycin Hydrochloride for Injection USP", "Vancomycin Hydrochloride for Injection USP", "Vancomycin Hydrochloride for Injection USP", "Vancomycin Hydrochloride for Injection USP", "Vancomycin Hydrochloride for Injection USP", "Vancomycin Hydrochloride for Injection USP", "Vancomycin Hydrochloride for Injection, USP", "Vancomycin Hydrochloride for Injection, USP", "Vancomycin Hydrochloride for Injection, USP", "Vancomycin Hydrochloride for Injection, USP", "Vancomycin Hydrochloride for Injection, USP", "Vancomycin Hydrochloride for Injection, USP", "Vancomycin Hydrochloride for Injection, USP", "Vancomycin Hydrochloride for Injection, USP", "Vancomycin Hydrochloride for Injection, USP", "Vancomycin Hydrochloride for Injection, USP", "Vancomycin Hydrochloride for Injection, USP", "Vancomycin Hydrochloride for Injection, USP", "Vancomycin Hydrochloride for Injection, USP", "Vancomycin Hydrochloride for Injection, USP", "Vancomycin Hydrochloride for Injection, USP", "Vancomycin Hydrochloride for Injection, USP", "Vancomycin Hydrochloride for Injection, USP", "Vancomycin Hydrochloride for Injection, USP", "Vancomycin Hydrochloride for Injection, USP", "Vancomycin Hydrochloride for Injection, USP", "Vancomycin Hydrochloride for Injection, USP", "Vancomycin Hydrochloride for Injection, USP", "Vancomycin Hydrochloride for Injection, USP", "Vancomycin Hydrochloride for Injection, USP", "Vancomycin Hydrochloride for Injection, USP", "Vancomycin Hydrochloride for Injection, USP", "Vancomycin Hydrochloride for Injection, USP", "Vancomycin Hydrochloride for Injection, USP", "Vancomycin Hydrochloride for Injection, USP", "Vancomycin Hydrochloride for Injection, USP", "Vancomycin Hydrochloride for Injection, USP", "Vancomycin Hydrochloride for Injection, USP", "Vancomycin Hydrochloride for Injection, USP", "Vancomycin Hydrochloride for Injection, USP", "Vancomycin Hydrochloride for Injection, USP", "Vancomycin Hydrochloride for Oral Solution", "Vancomycin Hydrochloride for Oral Solution", "Vancomycin Hydrochloride for Oral Solution", "Vancomycin Hydrochloride for Oral Solution", "Vancomycin Hydrocloride", "Vancomycin Injection USP In 0.9% Sodium Chloride", "Vancomycin Injection USP In 5% Dextrose" ]	[ "COVANC", "Vancoled" ]	[ "Firvanq", "Firvanq", "Firvanq", "Firvanq", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride", "Vancomycin Hydrochloride" ]	[]	[]	[ "P02768", "P02763", "P19652" ]	[]
DB00513	Aminocaproic acid	An antifibrinolytic agent that acts by inhibiting plasminogen activators which have fibrinolytic properties.	solid	For use in the treatment of excessive postoperative bleeding.	Aminocaproic acid works as an antifibrinolytic. It is a derivative of the amino acid lysine. The fibrinolysis-inhibitory effects of aminocaproic acid appear to be exerted principally via inhibition of plasminogen activators and to a lesser degree through antiplasmin activity. Aminocaproic acid may be a possible prophylactic for vascular disease, as it may prevent formation of lipoprotein (a), a risk factor for vascular disease.	Aminocaproic acid binds reversibly to the kringle domain of plasminogen and blocks the binding of plasminogen to fibrin and its activation to plasmin. With NO activation of plasmin, there is a reduction in fibrinolysis. This consequently will reduce the amount of bleeding post surgery. Elevated plasma levels of lipoprotein(a) have been shown to increase the risk of vascular disease. Lipoprotein 9a)a has two components, apolipoprotein B-100, linked to apolipoprotein (a). Aminocaproic acid may change the conformation of apoliprotein (a), changing its binding properties and potentially preventing the formation of lipoprotein (a).	Absorbed rapidly following oral administration. In adults, oral absorption appears to be a zero-order process with an absorption rate of 5.2 g/hr. The mean lag time in absorption is 10 minutes. After a single oral dose of 5 g, absorption was complete (F=1).	Sixty-five percent of the dose is recovered in the urine as unchanged drug and 11% of the dose appears as the metabolite adipic acid.	A few cases of acute overdosage with intravenous administration have been reported. The effects have ranged from no reaction to transient hypotension to severe acute renal failure leading to death. The intravenous and oral LD<sub>50</sub> were 3.0 and 12.0 g/kg respectively in the mouse and 3.2 and 16.4 g/kg respectively in the rat. An intravenous infusion dose of 2.3 g/kg was lethal in the dog.	The terminal elimination half-life is approximately 2 hours.	null	Renal excretion is the primary route of elimination, whether aminocaproic acid is administered orally or intravenously.	* 23.1 ± 6.6 L	* 169 mL/min	Organic compounds	Lipids and lipid-like molecules	Fatty Acyls	Fatty acids and conjugates	[ "approved", "investigational" ]	[ "B02AA", "B02A", "B02", "B" ]	[ "Humans and other mammals" ]	[ { "cost": "2.28", "description": "Aminocaproic acid 500 mg tablet", "unit": "tablet" }, { "cost": "3.67", "description": "Amicar 500 mg tablet", "unit": "tablet" }, { "cost": "7.17", "description": "Amicar 1000 mg tablet", "unit": "tablet" }, { "cost": "0.06", "description": "Aminocaproic acid 250 mg/ml", "unit": "ml" } ]	[]	6-Aminocaproic acid \| 6-aminohexanoic acid \| Acide aminocaproïque \| Ácido aminocapróico \| acidum aminocaproicum \| Aminocaproic acid \| Aminocapronsäure \| EACA \| EACS \| Epsilcapramine \| Epsilon Aminocaproic Acid \| Epsilon-Aminocaproic acid \| epsilon-Aminohexanoic acid \| omega-Aminocaproic acid \| omega-Aminohexanoic acid \| 3.4.21.7 \| 3.4.21.68 \| t-PA \| t-plasminogen activator \| tPA \| 3.4.21.- \| Apo(a) \| Lp(a) \| 1.2.3.1 \| Aldehyde oxidase 1 \| AO \| Azaheterocycle hydroxylase	[ "28tak Gum Care Tooth", "Amicar", "Amicar", "Amicar", "Amicar", "Amicar", "Amicar", "Amicar", "Amicar", "Amicar", "Amicar", "Amicar - Syr 250mg/ml", "Amicar - Tab, 500mg", "Amicar Inj 250mg/ml", "Amicar Injection - Liq IV 250mg/ml", "Amicar Syr 250mg/ml", "Amicar Tab 500mg", "Aminocaproic Acid", "Aminocaproic Acid", "Aminocaproic Acid", "Aminocaproic Acid", "Aminocaproic Acid", "Aminocaproic Acid", "Aminocaproic Acid", "Aminocaproic Acid", "Aminocaproic Acid", "Aminocaproic acid", "Aminocaproic Acid", "Aminocaproic acid", "Aminocaproic Acid", "Aminocaproic Acid", "Aminocaproic Acid", "Aminocaproic Acid", "Aminocaproic acid", "Aminocaproic Acid", "Aminocaproic acid", "Aminocaproic acid", "Aminocaproic Acid", "Aminocaproic acid", "Aminocaproic Acid", "Aminocaproic Acid", "Aminocaproic Acid", "Aminocaproic acid", "Aminocaproic Acid", "Aminocaproic Acid", "Aminocaproic acid", "Aminocaproic acid", "Aminocaproic Acid", "Aminocaproic Acid", "Aminocaproic Acid", "Aminocaproic Acid", "Aminocaproic Acid", "Aminocaproic Acid", "Aminocaproic Acid", "Aminocaproic Acid", "Aminocaproic Acid", "Aminocaproic acid", "Aminocaproic Acid", "Aminocaproic Acid", "Aminocaproic Acid", "Aminocaproic Acid", "Aminocaproic Acid", "Aminocaproic Acid", "Aminocaproic acid", "Aminocaproic Acid", "Aminocaproic Acid", "Aminocaproic Acid", "Aminocaproic Acid", "Aminocaproic Acid", "Aminocaproic Acid", "BAMBOO SALT Eunganggo Jook Yeom", "BAMBOO SALT Eunganggo Jook Yeom Toothpaste", "Clean Breath Tooth", "Clean Breath Tooth", "Clean Breath Tooth", "Dr.EL GUM CARE TOOTH", "Dr.LORD Green Propol Tooth", "Exoden White Tooth", "Gray Salt", "Gray Salt Tooth", "Gray Salt Tooth", "Gray Salt Tooth", "Greensaltrain Tooth", "Greensaltrain Tooth", "Greensaltrain Tooth", "Hae Yan Tooth", "Hea YanToothpaste", "HiMangChanToothpaste", "LACSIAN new perfect all care tooth", "Mastikis Gold", "Mastikis Mastic 24K", "Mastikis Mastic GumCare", "NAVI Black and C-Clinic", "Relief and Nature Toothpast E Jasmine Mint", "Rootsallo Toothpaste", "Salt Tooth", "Salt Tooth", "Saltrain Tooth", "Saltrain Tooth", "Solco Platino Iondenti Tooth", "Solmeet", "Solmeet", "Solmeet denti doctor", "Solmeet denti doctor", "Yumaki Original Mint Tooth" ]	[ "Acepramin", "Amocap", "Caproamin", "Caprocat", "Caprolisin", "E-Capro", "Epsicaprom", "Hemocid", "Inselon", "Ipron", "Ipsilon", "Kai Nai Yin", "Minocap", "Plaslloid", "Resplamin" ]	[ "Solmeet denti doctor", "Solmeet", "Solmeet denti doctor", "Solmeet", "BAMBOO SALT Eunganggo Jook Yeom Toothpaste", "BAMBOO SALT Eunganggo Jook Yeom", "Yumaki Original Mint Tooth", "28tak Gum Care Tooth", "Gray Salt Tooth", "Dr.EL GUM CARE TOOTH", "HiMangChanToothpaste", "Gray Salt Tooth", "LACSIAN new perfect all care tooth", "Hae Yan Tooth", "Relief and Nature Toothpast E Jasmine Mint", "Salt Tooth", "Exoden White Tooth", "NAVI Black and C-Clinic", "Salt Tooth", "Mastikis Gold", "Mastikis Mastic 24K", "Gray Salt Tooth", "Gray Salt", "Clean Breath Tooth", "Clean Breath Tooth", "Greensaltrain Tooth", "Greensaltrain Tooth", "Saltrain Tooth", "Mastikis Mastic GumCare", "Clean Breath Tooth", "Saltrain Tooth", "Greensaltrain Tooth", "Rootsallo Toothpaste", "Dr.LORD Green Propol Tooth", "Hea YanToothpaste" ]	[ "P00747", "P00750", "P08519" ]	[ "Q06278" ]	[]	[]
DB00514	Dextromethorphan	Dextromethorphan is a levorphanol derivative and codeine analog commonly used as a cough suppressant and also a drug of abuse.[A215412] Although similar in structure to other opioids, it has minimal interaction with opioid receptors.[A215412] Dextromethorphan was granted FDA approval before 3 December 1957.[A215412,L14997]	solid	Dextromethorphan is indicated in combination with [brompheniramine] and [pseudoephedrine] in the treatment of coughs and upper respiratory symptoms associated with allergies or the common cold.[L14366] Dextromethorphan is also used in combination with [guaifenesin] as an over-the-counter product to relieve a cough.[L14369] Dextromethorphan in combination with [quinidine] is indicated in the treatment of pseudobulbar affect.[L14363]	Dextromethorphan is an opioid-like molecule indicated in combination with other medication in the treatment of coughs and pseudobulbar affect.[L14366,L14369,L14363] It has a moderate therapeutic window, as intoxication can occur at higher doses.[A215402] Dextromethorphan has a moderate duration of action.[L14363] Patients should be counselled regarding the risk of intoxication.[A215402]	Dextromethorphan is a low-affinity uncompetitive NMDA antagonist and sigma-1 receptor agonist.[L14363] It is also an antagonist of α3/β4 nicotinic receptors.[A10589] However, the mechanism by which dextromethorphan's receptor agonism and antagonism translate to a clinical effect is not well understood.[A215397]	A 30mg oral dose of dextromethorphan reaches a C<sub>max</sub> of 2.9 ng/mL, with a T<sub>max</sub> of 2.86 h, and an AUC of 17.8 ng\*h/mL.[A34933]	Dextromethorphan can be N-demethylated to 3-methoxymorphinan by CYP3A4, CYP2D6, and CYP2C9 or O-demethylated to dextrorphan by CYP2D6 and CYP2C9.[A415] Dextrorphan is N-demethylated by CYP3A4 and CYP2D6, while 3-methoxymorphinan is O-demethylated by CYP2D6.[A415] Both are metabolized to form 3-hydroxymorphinan.[A415] Dextrorphan and 3-hydroxymorphinan are both O-glucuronidated or O-sulfated.[A415]	A dextromethorphan overdose may present as nausea, vomiting, stupor, coma, respiratory depression, seizures, tachycardia, hyperexcitability, toxic psychosis, ataxia, nystagmus, dystonia, blurred vision, changes in muscle reflexes, and serotonin syndrome.[L14363] Overdose should be managed through symptomatic and supportive measures.[L14363]	Dextromethorphan has a half life of 3-30 hours.[A215382]	Dextromethorphan is 60-70% protein bound in serum.[L14363]	null	The volume of distribution of dextromethorphan is 5-6.7L/kg.[A215382]	null	Organic compounds	Alkaloids and derivatives	Morphinans	null	[ "approved" ]	[ "N06AX", "N06A", "N06", "N", "R05DA", "R05D", "R05", "R", "N07XX", "N07X", "N07", "N" ]	[ "Humans and other mammals" ]	[ { "cost": "2.06", "description": "Dextromethorphan hbr cryst", "unit": "g" }, { "cost": "4.74", "description": "Dextromethorphan hbr powder", "unit": "g" }, { "cost": "14.93", "description": "Dextromethorphan powder", "unit": "g" }, { "cost": "59.99", "description": "Modicon (28) 28 0.5-35 mg-mcg tablet Disp Pack", "unit": "disp" }, { "cost": "0.02", "description": "Guaifenesin dm syrup", "unit": "ml" }, { "cost": "0.03", "description": "Vicks 44 cough liquid", "unit": "ml" }, { "cost": "0.03", "description": "Vicks 44 custom care liquid", "unit": "ml" }, { "cost": "0.04", "description": "Adlt robitussin cough-cold-flu", "unit": "ml" }, { "cost": "0.04", "description": "Adt robitussin cough-cold d lq", "unit": "ml" }, { "cost": "0.04", "description": "Adult robitussin cough syrup", "unit": "ml" }, { "cost": "0.04", "description": "Robitussin chest congest syrup", "unit": "ml" }, { "cost": "0.04", "description": "Robitussin cough & cold liquid", "unit": "ml" }, { "cost": "0.04", "description": "Robitussin cough-cold liquid", "unit": "ml" }, { "cost": "0.04", "description": "Robitussin cough-cong syrup", "unit": "ml" }, { "cost": "0.04", "description": "Robitussin dm max liquid", "unit": "ml" }, { "cost": "0.04", "description": "Robitussin long-acting liq", "unit": "ml" }, { "cost": "0.04", "description": "Robitussin pe head & chest liq", "unit": "ml" }, { "cost": "0.04", "description": "Robitussin-cough-chest-cong lq", "unit": "ml" }, { "cost": "0.04", "description": "Robitussin-dm cough syrup", "unit": "ml" }, { "cost": "0.04", "description": "Triaminic chest-nasal cong liq", "unit": "ml" }, { "cost": "0.04", "description": "Triaminic cold & cough liquid", "unit": "ml" }, { "cost": "0.04", "description": "Triaminic cold-allergy pe liq", "unit": "ml" }, { "cost": "0.04", "description": "Triaminic cough-nasal cong liq", "unit": "ml" }, { "cost": "0.04", "description": "Triaminic cough-sore throat lq", "unit": "ml" }, { "cost": "0.04", "description": "Triaminic flu cough-fever susp", "unit": "ml" }, { "cost": "0.04", "description": "Triaminic flu-cough-fever liq", "unit": "ml" }, { "cost": "0.04", "description": "Triaminic-d syrup", "unit": "ml" }, { "cost": "0.05", "description": "Apap allergy sinus caplet", "unit": "caplet" }, { "cost": "0.09", "description": "Robitussin dm to go liquid", "unit": "ml" }, { "cost": "0.11", "description": "Delsym 30 mg/5 ml suspension", "unit": "ml" }, { "cost": "0.23", "description": "Hca severe cough stopper cplet", "unit": "each" }, { "cost": "0.23", "description": "Triaminicin tablet", "unit": "tablet" }, { "cost": "0.24", "description": "Childrens triaminic decon spray", "unit": "ml" }, { "cost": "0.24", "description": "Hold 4 hour lozenge regular", "unit": "lozenge" }, { "cost": "0.25", "description": "Robitussin coughgels", "unit": "each" }, { "cost": "0.25", "description": "Triaminic softchews tablet", "unit": "tablet" }, { "cost": "0.27", "description": "Triaminic cough-cold chew", "unit": "each" }, { "cost": "0.27", "description": "Triaminic softchew tablet", "unit": "tablet" }, { "cost": "0.3", "description": "Triaminic cgh-runny nose strip", "unit": "each" }, { "cost": "0.3", "description": "Triaminic cough strips", "unit": "strip" }, { "cost": "0.35", "description": "Triaminic allergy thin strip", "unit": "strip" }, { "cost": "0.35", "description": "Triaminic cold-stuff nose strip", "unit": "strip" } ]	[ { "approved": "1999-11-09", "country": "United States", "expires": "2017-04-16", "number": "5980882" }, { "approved": "2002-04-16", "country": "United States", "expires": "2020-04-28", "number": "6372252" }, { "approved": "2005-10-18", "country": "United States", "expires": "2020-04-28", "number": "6955821" }, { "approved": "2010-11-23", "country": "United States", "expires": "2020-04-28", "number": "7838032" }, { "approved": "2010-02-09", "country": "United States", "expires": "2026-08-13", "number": "7659282" }, { "approved": "2012-07-24", "country": "United States", "expires": "2023-07-17", "number": "8227484" }, { "approved": "2003-05-06", "country": "United States", "expires": "2016-01-26", "number": "RE38115" }, { "approved": "2014-11-05", "country": "United States", "expires": "2034-11-05", "number": "11382874" }, { "approved": "2014-11-05", "country": "United States", "expires": "2034-11-05", "number": "11364233" }, { "approved": "2016-10-04", "country": "United States", "expires": "2034-11-05", "number": "9457025" }, { "approved": "2018-08-28", "country": "United States", "expires": "2034-11-05", "number": "10058518" }, { "approved": "2016-03-08", "country": "United States", "expires": "2034-11-05", "number": "9278095" }, { "approved": "2018-01-16", "country": "United States", "expires": "2034-11-05", "number": "9867819" }, { "approved": "2015-10-27", "country": "United States", "expires": "2034-11-05", "number": "9168234" }, { "approved": "2018-01-09", "country": "United States", "expires": "2034-11-05", "number": "9861595" }, { "approved": "2013-10-29", "country": "United States", "expires": "2033-10-29", "number": "8569328" }, { "approved": "2017-07-11", "country": "United States", "expires": "2034-11-05", "number": "9700553" }, { "approved": "2014-11-05", "country": "United States", "expires": "2034-11-05", "number": "11357744" }, { "approved": "2014-11-05", "country": "United States", "expires": "2034-11-05", "number": "11344544" }, { "approved": "2016-11-08", "country": "United States", "expires": "2034-11-05", "number": "9486450" }, { "approved": "2016-10-25", "country": "United States", "expires": "2034-11-05", "number": "9474731" }, { "approved": "2016-06-28", "country": "United States", "expires": "2034-11-05", "number": "9375429" }, { "approved": "2016-08-23", "country": "United States", "expires": "2034-11-05", "number": "9421176" }, { "approved": "2016-08-09", "country": "United States", "expires": "2034-11-05", "number": "9408815" }, { "approved": "2017-09-19", "country": "United States", "expires": "2034-11-05", "number": "9763932" }, { "approved": "2014-11-05", "country": "United States", "expires": "2034-11-05", "number": "11311534" }, { "approved": "2015-12-08", "country": "United States", "expires": "2034-11-05", "number": "9205083" }, { "approved": "2017-07-18", "country": "United States", "expires": "2034-11-05", "number": "9707191" }, { "approved": "2021-01-26", "country": "United States", "expires": "2034-11-05", "number": "10898453" }, { "approved": "2014-11-05", "country": "United States", "expires": "2034-11-05", "number": "11433067" }, { "approved": "2017-07-11", "country": "United States", "expires": "2034-11-05", "number": "9700528" }, { "approved": "2016-06-21", "country": "United States", "expires": "2034-11-05", "number": "9370513" }, { "approved": "2016-10-04", "country": "United States", "expires": "2034-11-05", "number": "9457023" }, { "approved": "2016-01-19", "country": "United States", "expires": "2034-11-05", "number": "9238032" }, { "approved": "2021-08-24", "country": "United States", "expires": "2034-11-05", "number": "11096937" }, { "approved": "2014-11-05", "country": "United States", "expires": "2034-11-05", "number": "11298352" }, { "approved": "2021-04-06", "country": "United States", "expires": "2034-11-05", "number": "10966941" }, { "approved": "2014-11-05", "country": "United States", "expires": "2034-11-05", "number": "11298351" }, { "approved": "2021-08-17", "country": "United States", "expires": "2034-11-05", "number": "11090300" }, { "approved": "2021-01-19", "country": "United States", "expires": "2034-11-05", "number": "10894047" }, { "approved": "2018-09-04", "country": "United States", "expires": "2034-11-05", "number": "10064857" }, { "approved": "2014-11-05", "country": "United States", "expires": "2034-11-05", "number": "11291665" }, { "approved": "2020-09-22", "country": "United States", "expires": "2034-11-09", "number": "10780066" }, { "approved": "2020-09-22", "country": "United States", "expires": "2040-01-07", "number": "10780064" }, { "approved": "2014-11-05", "country": "United States", "expires": "2034-11-05", "number": "11291638" }, { "approved": "2020-09-29", "country": "United States", "expires": "2034-11-05", "number": "10786469" }, { "approved": "2014-11-05", "country": "United States", "expires": "2034-11-05", "number": "11253492" }, { "approved": "2021-01-05", "country": "United States", "expires": "2034-11-05", "number": "10881657" }, { "approved": "2020-12-29", "country": "United States", "expires": "2034-11-05", "number": "10874663" }, { "approved": "2020-10-13", "country": "United States", "expires": "2034-11-05", "number": "10799497" }, { "approved": "2021-07-13", "country": "United States", "expires": "2034-11-05", "number": "11058648" }, { "approved": "2014-11-05", "country": "United States", "expires": "2034-11-05", "number": "11273133" }, { "approved": "2020-12-15", "country": "United States", "expires": "2034-11-05", "number": "10864209" }, { "approved": "2020-10-20", "country": "United States", "expires": "2034-11-05", "number": "10806710" }, { "approved": "2021-01-05", "country": "United States", "expires": "2034-11-05", "number": "10881624" }, { "approved": "2020-09-29", "country": "United States", "expires": "2034-11-05", "number": "10786496" }, { "approved": "2021-06-01", "country": "United States", "expires": "2034-11-05", "number": "11020389" }, { "approved": "2021-11-30", "country": "United States", "expires": "2034-11-05", "number": "11185515" }, { "approved": "2021-03-16", "country": "United States", "expires": "2034-11-05", "number": "10945973" }, { "approved": "2021-04-06", "country": "United States", "expires": "2040-01-07", "number": "10966942" }, { "approved": "2014-11-05", "country": "United States", "expires": "2034-11-05", "number": "11285146" }, { "approved": "2014-11-05", "country": "United States", "expires": "2034-11-05", "number": "11285118" }, { "approved": "2020-03-24", "country": "United States", "expires": "2034-11-05", "number": "10596167" }, { "approved": "2014-11-05", "country": "United States", "expires": "2034-11-05", "number": "11439636" }, { "approved": "2016-04-19", "country": "United States", "expires": "2034-11-05", "number": "9314462" }, { "approved": "2015-12-01", "country": "United States", "expires": "2034-11-05", "number": "9198905" }, { "approved": "2014-11-05", "country": "United States", "expires": "2034-11-05", "number": "11426401" }, { "approved": "2014-11-05", "country": "United States", "expires": "2034-11-05", "number": "11426370" }, { "approved": "2014-11-05", "country": "United States", "expires": "2034-11-05", "number": "11419867" }, { "approved": "2020-09-15", "country": "United States", "expires": "2034-11-05", "number": "10772850" }, { "approved": "2021-03-09", "country": "United States", "expires": "2040-01-07", "number": "10940124" }, { "approved": "2014-11-05", "country": "United States", "expires": "2034-11-05", "number": "11273134" }, { "approved": "2014-11-05", "country": "United States", "expires": "2034-11-05", "number": "11253491" }, { "approved": "2014-11-05", "country": "United States", "expires": "2034-11-05", "number": "11234946" }, { "approved": "2020-02-04", "country": "United States", "expires": "2034-11-05", "number": "10548857" }, { "approved": "2014-11-05", "country": "United States", "expires": "2034-11-05", "number": "11229640" }, { "approved": "2020-12-29", "country": "United States", "expires": "2034-11-05", "number": "10874665" }, { "approved": "2021-03-02", "country": "United States", "expires": "2034-11-05", "number": "10933034" }, { "approved": "2019-04-09", "country": "United States", "expires": "2034-11-05", "number": "10251879" }, { "approved": "2021-02-23", "country": "United States", "expires": "2040-01-07", "number": "10925842" }, { "approved": "2018-10-09", "country": "United States", "expires": "2034-11-05", "number": "10092561" }, { "approved": "2021-01-19", "country": "United States", "expires": "2034-11-05", "number": "10894046" }, { "approved": "2021-12-07", "country": "United States", "expires": "2034-11-05", "number": "11191739" }, { "approved": "2020-12-29", "country": "United States", "expires": "2034-11-05", "number": "10874664" }, { "approved": "2018-09-25", "country": "United States", "expires": "2034-11-05", "number": "10080727" }, { "approved": "2021-12-14", "country": "United States", "expires": "2034-11-05", "number": "11197839" }, { "approved": "2021-10-19", "country": "United States", "expires": "2034-11-05", "number": "11147808" }, { "approved": "2021-12-28", "country": "United States", "expires": "2034-11-05", "number": "11207281" }, { "approved": "2021-10-12", "country": "United States", "expires": "2034-11-05", "number": "11141416" }, { "approved": "2021-10-12", "country": "United States", "expires": "2034-11-05", "number": "11141388" }, { "approved": "2014-11-05", "country": "United States", "expires": "2034-11-05", "number": "11213521" }, { "approved": "2021-09-28", "country": "United States", "expires": "2034-11-05", "number": "11129826" }, { "approved": "2021-09-21", "country": "United States", "expires": "2034-11-05", "number": "11123343" }, { "approved": "2021-04-06", "country": "United States", "expires": "2034-11-05", "number": "10966974" }, { "approved": "2019-12-24", "country": "United States", "expires": "2034-11-05", "number": "10512643" }, { "approved": "2019-11-05", "country": "United States", "expires": "2034-11-05", "number": "10463634" }, { "approved": "2018-10-23", "country": "United States", "expires": "2034-11-05", "number": "10105361" }, { "approved": "2018-10-23", "country": "United States", "expires": "2034-11-05", "number": "10105327" }, { "approved": "2018-10-09", "country": "United States", "expires": "2034-11-05", "number": "10092560" }, { "approved": "2018-05-15", "country": "United States", "expires": "2034-11-05", "number": "9968568" }, { "approved": "2014-11-05", "country": "United States", "expires": "2034-11-05", "number": "11510918" }, { "approved": "2014-11-05", "country": "United States", "expires": "2034-11-05", "number": "11478468" }, { "approved": "2014-11-05", "country": "United States", "expires": "2034-11-05", "number": "11497721" }, { "approved": "2014-11-05", "country": "United States", "expires": "2034-11-05", "number": "11524008" }, { "approved": "2014-11-05", "country": "United States", "expires": "2034-11-05", "number": "11524007" }, { "approved": "2014-11-05", "country": "United States", "expires": "2034-11-05", "number": "11517542" }, { "approved": "2014-11-05", "country": "United States", "expires": "2034-11-05", "number": "11517543" }, { "approved": "2014-11-05", "country": "United States", "expires": "2034-11-05", "number": "11541048" }, { "approved": "2014-11-05", "country": "United States", "expires": "2034-11-05", "number": "11541021" }, { "approved": "2014-11-05", "country": "United States", "expires": "2034-11-05", "number": "11534414" }, { "approved": "2014-11-05", "country": "United States", "expires": "2034-11-05", "number": "11596627" }, { "approved": "2014-11-05", "country": "United States", "expires": "2034-11-05", "number": "11617728" }, { "approved": "2014-11-05", "country": "United States", "expires": "2034-11-05", "number": "11617747" }, { "approved": "2023-01-23", "country": "United States", "expires": "2043-01-23", "number": "11730706" }, { "approved": "2023-01-20", "country": "United States", "expires": "2043-01-20", "number": "11717518" }, { "approved": "2023-02-23", "country": "United States", "expires": "2043-02-23", "number": "11752144" }, { "approved": "2014-11-05", "country": "United States", "expires": "2034-11-05", "number": "11779579" }, { "approved": "2023-04-20", "country": "United States", "expires": "2043-04-20", "number": "11844797" }, { "approved": "2023-03-02", "country": "United States", "expires": "2043-03-02", "number": "11839612" }, { "approved": "2021-12-01", "country": "United States", "expires": "2041-12-01", "number": "11896563" }, { "approved": "2023-01-23", "country": "United States", "expires": "2043-01-23", "number": "11883373" }, { "approved": "2023-01-20", "country": "United States", "expires": "2043-01-20", "number": "11925636" }, { "approved": "2014-11-05", "country": "United States", "expires": "2034-11-05", "number": "11969421" }, { "approved": "2023-02-15", "country": "United States", "expires": "2043-02-15", "number": "11986444" }, { "approved": "2023-02-23", "country": "United States", "expires": "2043-02-23", "number": "12042473" }, { "approved": "2023-02-15", "country": "United States", "expires": "2043-02-15", "number": "12036191" }, { "approved": "2014-11-05", "country": "United States", "expires": "2034-11-05", "number": "12109178" } ]	(+)-dextromethorphan \| D-methorphan \| delta-Methorphan \| Dex \| Dextromethorfan \| Dextromethorphan \| Dextrométhorphane \| Dextromethorphanum \| Dextrometorfano \| DM \| Aging-associated gene 8 protein \| hSigmaR1 \| OPRS1 \| SIG-1R \| Sigma 1-type opioid receptor \| Sigma1-receptor \| Sigma1R \| SR-BP \| SR31747-binding protein \| SRBP \| 1.14.14.14 \| ARO1 \| CYAR \| CYP19 \| CYPXIX \| Cytochrome P-450AROM \| Cytochrome P450 19A1 \| Estrogen synthase \| GluN3A \| KIAA1973 \| N-methyl-D-aspartate receptor subtype 3A \| NMDAR-L \| NMDAR3A \| NR3A \| 5HT transporter \| 5HTT \| HTT \| SERT \| Solute carrier family 6 member 4 \| Dap1 \| HPR6.6 \| IZA \| mPR \| PGRMC \| NACHRA3 \| NACRA4 \| NACHRA7 \| hMOP \| M-OR-1 \| MOP \| MOR-1 \| MOR1 \| Mu opiate receptor \| Mu opioid receptor \| D-OR-1 \| DOR-1 \| OPRD \| K-OR-1 \| KOR-1 \| OPRK \| 1.-.-.- \| CGD91-phox \| Cytochrome b(558) subunit beta \| Cytochrome b558 subunit beta \| gp91-1 \| gp91-phox \| Heme-binding membrane glycoprotein gp91phox \| NADPH oxidase 2 \| Neutrophil cytochrome b 91 kDa polypeptide \| NOX2 \| p22 phagocyte B-cytochrome \| Superoxide-generating NADPH oxidase heavy chain subunit \| Cytochrome b(558) alpha chain \| Cytochrome b558 subunit alpha \| Neutrophil cytochrome b 22 kDa polypeptide \| p22 phagocyte B-cytochrome \| p22-phox \| p22phox \| Superoxide-generating NADPH oxidase light chain subunit \| 47 kDa autosomal chronic granulomatous disease protein \| 47 kDa neutrophil oxidase factor \| NCF-1 \| NCF-47K \| Neutrophil NADPH oxidase factor 1 \| Nox organizer 2 \| Nox-organizing protein 2 \| NOXO2 \| p47-phox \| SH3 and PX domain-containing protein 1A \| SH3PXD1A \| 67 kDa neutrophil oxidase factor \| NADPH oxidase activator 2 \| NCF-2 \| Neutrophil NADPH oxidase factor 2 \| NOXA2 \| p67-phox \| P67PHOX \| NCF-4 \| Neutrophil NADPH oxidase factor 4 \| p40-phox \| p40phox \| SH3 and PX domain-containing protein 4 \| SH3PXD4 \| 3.6.5.2 \| Cell migration-inducing gene 5 protein \| p21-Rac1 \| Ras-like protein TC25 \| TC25 \| GX \| p21-Rac2 \| Small G protein \| NAT1 \| NET \| NET1 \| Norepinephrine transporter \| SLC6A5 \| Solute carrier family 6 member 2 \| 1.14.14.- \| Cholesterol 25-hydroxylase \| CYP2DL1 \| CYPIID6 \| Cytochrome P450-DB1 \| Debrisoquine 4-hydroxylase \| 1,4-cineole 2-exo-monooxygenase \| 1,8-cineole 2-exo-monooxygenase \| 1.14.14.1 \| Albendazole monooxygenase (sulfoxide-forming) \| Albendazole sulfoxidase \| Cholesterol 25-hydroxylase \| CYP3A3 \| CYPIIIA3 \| CYPIIIA4 \| Cytochrome P450 3A3 \| Cytochrome P450 HLp \| Cytochrome P450 NF-25 \| Cytochrome P450-PCN1 \| Nifedipine oxidase \| Quinine 3-monooxygenase \| 1.14.14.1 \| CYPIIIA7 \| Cytochrome P450-HFLA \| P450HLp2 \| 1,4-cineole 2-exo-monooxygenase \| 1.14.13.- \| CYPIIB6 \| Cytochrome P450 IIB1 \| (R)-limonene 6-monooxygenase \| (S)-limonene 6-monooxygenase \| (S)-limonene 7-monooxygenase \| 1.14.14.1 \| CYPIIC17 \| CYPIIC19 \| Cytochrome P450-11A \| Cytochrome P450-254C \| Fenbendazole monooxygenase (4'-hydroxylating) \| Mephenytoin 4-hydroxylase \| (R)-limonene 6-monooxygenase \| (S)-limonene 6-monooxygenase \| (S)-limonene 7-monooxygenase \| 1.14.14.1 \| Cholesterol 25-hydroxylase \| CYP2C10 \| CYPIIC9 \| Cytochrome P-450MP \| Cytochrome P450 MP-4 \| Cytochrome P450 MP-8 \| Cytochrome P450 PB-1 \| S-mephenytoin 4-hydroxylase \| 2.4.1.17 \| HLUG25 \| Hyodeoxycholic acid-specific UDPGT \| UDPGT 2B4 \| UDPGTh-1 \| UGT2B11 \| UGT2B4 \| 2.4.1.17 \| 3,4-catechol estrogen-specific UDPGT \| UDP-glucuronosyltransferase 2B9 \| UDPGT 2B7 \| UDPGT 2B9 \| UDPGTh-2 \| UGT2B7 \| UGTB2B9 \| 2.4.1.17 \| HLUG4 \| UDP-glucuronosyltransferase 2B8 \| UDPGT 2B15 \| UDPGT 2B8 \| UDPGTh-3 \| UGT2B15 \| UGT2B8 \| 2.4.1.17 \| C19-steroid-specific UDP-glucuronosyltransferase \| C19-steroid-specific UDPGT \| UDPGT 2B17 \| UGT2B17	[ "12 Hour Cough Relief", "12 Hour Cough Relief", "24/7 Life Cold and Flu DayTime Severe", "7 Select Cough DM", "7 Select Day Time Relief", "7 Select Day Time Relief", "7 Select Maximum Strength", "7 Select Night Time Relief", "7 Select Night Time Relief", "7 select Tussin DM", "A.M. Cold Relief Formula", "Abatuss Dmx", "Accu Tuss DM", "AccuHist PDX", "Acetaflu Cough and Chest Congestion", "AcetaFlu DayTime", "AcetaFlu DayTime Effervescent", "Acetaminophen 500mg, Dextromethorphan HBr 10mg, Guaifenesin 200mg, Phenylephrine HCl 5mg", "Acetaminophen Dextromethorphan HBr Doxylamine succinate Phenylephrine HCl", "Acetaminophen Dextromethorphan HBr Doxylamine succinate Phenylephrine HCl", "Acetaminophen Dextromethorphan HBr Guaifenesin Phenylephrine HCl", "ACETAMINOPHEN DEXTROMETHORPHAN HYDROBROMIDE and DOXYLAMINE SUCCINATE", "ACETAMINOPHEN DEXTROMETHORPHAN HYDROBROMIDE and PHENYLEPHRINE HYDROCHLORIDE", "Acetaminophen Dextromethorphan Hydrobromide Doxylamine Succinate Phenylephrine Hydrochloride", "Acetaminophen Dextromethorphan Hydrobromide Doxylamine Succinate Phenylephrine hydrochloride", "Acetaminophen Dextromethorphan Hydrobromide Phenylephrine Hydrochloride", "Acetaminophen Dextromethorphan Hydrobromide Phenylephrine Hydrochloride", "Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hydrobromide, Phenylephrine Hydrochloride", "Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hydrobromide, Phenylephrine Hydrochloride", "ACETAMINOPHEN, DEXTROMETHORPHAN HBr, GUAILFENESIN,PHENLYEPHRINE HCL", "Acetaminophen, Dextromethorphan HBr, Phenylephrine HCl, Doxylamine Succinate", "ACETAMINOPHEN, DEXTROMETHORPHAN HYDROBROMIDE, and DOXYLAMINE SUCCINATE", "ACETAMINOPHEN, DEXTROMETHORPHAN HYDROBROMIDE, and PHENYLEPHRINE HYDROCHLORIDE", "Acetaminophen, Dextromethorphan Hydrobromide, Doxylamine Succinate", "Acetaminophen, Dextromethorphan Hydrobromide, Guaifenesin, Phenylephrine Hydrochloride", "Acetaminophen, Dextromethorphan Hydrobromide, Guaifenesin, Phenylephrine Hydrochloride", "Acetaminophen, Dextromethorphan Hydrobromide, Guaifenesin, Phenylephrine Hydrochloride", "Acetaminophen, Dextromethorphan Hydrobromide, Guaifenesin, Phenylephrine Hydrochloride", "Acetaminophen, Dextromethorphan Hydrobromide, Phenylephrine Hydrochloride", "Acetaminophen, Dextromethorphan Hydrobromide, Phenylephrine Hydrochloride", "Acetaminophen, Dextromethorphan Hydrobromide, Phenylephrine Hydrochloride", "Acetaminophen, Guaifenesin, Dextromethorphan HBr, Phenylephrine HCl", "Acetaminophen, Guaifenesin, Dextromethorphan HBr, Phenylephrine HCl", "Acetaminophen,Dextromethorphan,Doxylamine", "Acetaminophen,Dextromethorphan,Phenylephrine", "Acetaminophen/dextromethorphan/pseudoephedrine", "Acetaminophen/pseudoephedrine/dextromethorphan/doxylamine", "Actidom Dmx", "Actifed DM Syrup", "Actifed DM Syrup", "Actifed DM Tablets", "Actifed DM Tablets", "Actinel", "Actinel DM", "Actinel Pediatric", "Activcin", "Adult Aurotussin Maximum Strength Nighttime Cough DM", "Adult CF Cough", "Adult Cold, Flu and Sore Throat", "Adult Cold, Flu and Sore Throat", "Adult Cough and Chest Congestion", "Adult Cough and Chest Congestion Relief DM Non Drowsy", "Adult Cough Relief DM", "Adult DM Max Cough and Chest Congestion", "Adult Honey Works", "Adult Long Lasting-Cough Relief", "Adult Severe Congestion and Cough", "Adult Severe Congestion and Cough", "Adult Tussin CF Multi-Symptom Cold", "Adult Tussin Cough", "Adult Tussin Cough and Chest Congestion DM", "Adult Tussin Cough and Chest Congestion DM", "Adult Tussin Cough and Chest Congestion DM Sugar Free", "Adult Tussin Cough and Chest Congestion DM Sugar Free", "Adult Tussin Cough and Chest Congestion DM Sugar Free", "Adult Tussin Cough and Chest Congestion DM Sugar Free", "Adult Tussin Cough and Chest Congestion DM Sugar Free", "Adult Tussin Cough and Chest Congestion DM Sugar Free", "Adult Tussin Cough and Cold CF", "Adult Tussin Cough Gels", "Adult Tussin DM", "Adult Tussin DM", "Adult Tussin DM", "Adult Tussin DM Cough Plus Chest Congestion DM", "Adult Tussin DM Lil Drug Store Products", "Adult Tussin DM Max", "Adult Tussin Maximum Strength Nighttime Cough DM", "Adult tussin Peak Cold Multi-Symptom Cold", "Adult Wal Tussin Cough Long Acting", "Adults Tussin DM", "Akin Cough Formula DM", "Akin Cough Formula DM Strawberry Banana", "Akin DM", "Alahist CF", "Alahist DM", "Alahist DM", "Alahist DM", "Aldex GS DM", "Algidol Flu", "Algidol Flu", "ALKA SELTZER PLUS Cold Day and Night Effervescent", "Alka Seltzer Plus Maximum Strength Cough Chest Congestion PowerFast Fizz", "Alka Seltzer Plus Maximum Strength Sinus, Allergy And Cough Power Max Gels", "Alka Seltzer Plus Severe Cold and Flu PowerFast Fizz", "Alka-Seltzer Plus Cold and Cough", "Alka-Seltzer Plus Cold and Cough", "Alka-Seltzer Plus Cold and Cough Cool Menthol", "Alka-Seltzer Plus Cold and Cough Formula", "Alka-Seltzer Plus Cold and Cough Formula", "Alka-Seltzer Plus Cold and Flu", "Alka-seltzer Plus Cold and Flu", "Alka-Seltzer Plus Cold and Flu, BASIX", "Alka-Seltzer Plus Cold and Flu, CVP", "Alka-Seltzer Plus Cold Day and Night", "Alka-Seltzer Plus Cold Day and Night", "Alka-Seltzer Plus Cold Day and Night PowerMax gels", "Alka-Seltzer Plus Cold Day and Night PowerMax gels", "Alka-Seltzer Plus Cold Day and Night PowerMax gels", "Alka-Seltzer Plus Cold Day and Night PowerMax gels", "Alka-Seltzer Plus Cold Night", "Alka-Seltzer Plus Cough, Mucus and Congestion Day and Night Powermax", "Alka-Seltzer Plus Cough, Mucus and Congestion Day and Night Powermax", "Alka-Seltzer Plus Day and Night Cold", "Alka-Seltzer Plus Day and Night Cold", "Alka-Seltzer Plus Day and Night Cold and Flu Formula", "Alka-Seltzer Plus Day and Night Cold and Flu Formula", "Alka-Seltzer Plus Day and Night Cold and Flu Formula", "Alka-Seltzer Plus Day and Night Cold and Flu Formula", "Alka-Seltzer Plus Day and Night Multi-Symptom Cold and Flu Formula", "Alka-Seltzer Plus Day and Night Multi-Symptom Cold and Flu Formula", "Alka-Seltzer Plus Day and Night Severe Cold and Flu", "Alka-Seltzer Plus Day and Night Severe Cold and Flu", "Alka-Seltzer Plus Day Cold and Flu", "Alka-Seltzer Plus Day Non Drowsy Cold Medicine Citrus", "Alka-Seltzer Plus Day Non-Drowsy Cold and Flu Formula", "Alka-Seltzer Plus Day Severe Cold Plus Flu", "Alka-Seltzer Plus Day Severe Cold, Cough And Flu", "Alka-Seltzer Plus Flu Formula", "Alka-Seltzer Plus Max Cough, Mucus and Congestion", "Alka-Seltzer Plus Maximum Strength Cold and Cough", "Alka-Seltzer Plus Maximum Strength Cold and Cough Liquid Gels with Cool Menthol Flavor Liquid Gels", "Alka-Seltzer Plus Maximum Strength Cold and Cough Power Max Gels", "Alka-Seltzer Plus Maximum Strength Cough and Mucus DM", "Alka-Seltzer Plus Maximum Strength Cough, Mucus and Congestion Day and Night", "Alka-Seltzer Plus Maximum Strength Cough, Mucus and Congestion Day and Night", "Alka-Seltzer Plus Maximum Strength Cough, Mucus and Congestion Powermax", "Alka-Seltzer Plus Maximum Strength Day and Night Cold and Flu", "Alka-Seltzer Plus Maximum Strength Day and Night Cold and Flu", "Alka-Seltzer Plus Maximum Strength Day and Night Cold and Flu", "Alka-Seltzer Plus Maximum Strength Day and Night Cold and Flu", "Alka-Seltzer Plus Maximum Strength Day and Night Cold and Flu", "Alka-Seltzer Plus Maximum Strength Day and Night Cold and Flu", "Alka-Seltzer Plus Maximum Strength Day and Night Cold and Flu PowerMax Gels", "Alka-Seltzer Plus Maximum Strength Day and Night Cold and Flu PowerMax Gels", "Alka-Seltzer Plus Maximum Strength Day and Night Cold and Flu PowerMax Gels", "Alka-Seltzer Plus Maximum Strength Day and Night Cold and Flu PowerMax Gels", "Alka-Seltzer Plus Maximum Strength Day Cold and Flu", "Alka-Seltzer Plus Maximum Strength Day Cold and Flu PowerMax Gels", "Alka-Seltzer Plus Maximum Strength Night Cold and Flu", "Alka-Seltzer Plus Maximum Strength Night Cold and Flu PowerMax Gels", "Alka-Seltzer Plus Maximum Strength Severe Sinus Congestion and Cough Day and Night", "Alka-Seltzer Plus Maximum Strength Severe Sinus Congestion and Cough Day and Night", "Alka-Seltzer Plus Maximum Strength Severe Sinus, Allergy and Cough", "Alka-Seltzer Plus Maximum Strength Sinus Congestion and Pain PowerFast Fizz", "Alka-Seltzer Plus Maximum Strength Sinus, Congestion and Pain Power Max Gels", "Alka-Seltzer Plus Multi-Smptom Cold and Flu Night", "Alka-Seltzer Plus Multi-Symptom Cold and Cough", "Alka-Seltzer Plus Multi-Symptom Cold and Flu Day and Night Liquid Gels", "Alka-Seltzer Plus Multi-Symptom Cold and Flu Day and Night Liquid Gels", "Alka-Seltzer Plus Multi-Symptom Cold and Flu Day Liquid Gels", "Alka-Seltzer Plus Multi-Symptom Cold Day and Night", "Alka-Seltzer Plus Multi-Symptom Cold Day and Night", "Alka-Seltzer Plus Multi-Symptom Cold Night", "Alka-Seltzer Plus Night Cold and Flu Formula", "Alka-Seltzer Plus Night Cold and Flu Formula", "Alka-Seltzer Plus Night Cold Formula (Lemon)", "Alka-Seltzer Plus Night Cold Medicine", "Alka-Seltzer Plus Night Severe Cold and Flu", "Alka-Seltzer Plus Severe Cold and Cough Night", "Alka-Seltzer Plus Severe Cold and Cough PowerFast Fizz", "Alka-Seltzer Plus Severe Cold and Flu", "Alka-Seltzer Plus Severe Cold And Flu Formula", "Alka-Seltzer Plus Severe Cold and Flu PowerFast Fizz", "Alka-Seltzer Plus Severe Cold and Flu PowerFast Fizz", "Alka-Seltzer Plus Severe Cold and Flu PowerFast Fizz", "Alka-Seltzer Plus Severe Cold and Flu PowerFast Fizz", "Alka-Seltzer Plus Severe Cold Night PowerFast Fizz", "Alka-Seltzer Plus Severe Cold Night PowerFast Fizz", "Alka-Seltzer Plus Severe Cold Night PowerFast Fizz", "Alka-Seltzer Plus Severe Cold PowerFast Fizz", "Alka-Seltzer Plus Severe Cold PowerFast Fizz", "Alka-Seltzer Plus Severe Cold PowerFast Fizz Day and Night", "Alka-Seltzer Plus Severe Cold PowerFast Fizz Day and Night", "Alka-Seltzer Plus Severe Cold PowerFast Fizz Day and Night", "Alka-Seltzer Plus Severe Cold PowerFast Fizz Day and Night", "Alka-Seltzer Plus Severe Cold PowerFast Fizz Day and Night", "Alka-Seltzer Plus Severe Cold PowerFast Fizz Day and Night", "Alka-Seltzer Plus Severe Cold PowerFast Fizz Day and Night", "Alka-Seltzer Plus Severe Cold PowerFast Fizz Day and Night", "Alka-Seltzer Plus Severe Cold Powerfast Fizz Night", "Alka-Seltzer Plus Severe Cold PowerFast Fizz Non Drowsy", "Alka-Seltzer Plus Severe Cold, Mucus and Congestion", "Alka-Seltzer Plus Severe Cough and Cold Day and Night", "Alka-Seltzer Plus Severe Cough and Cold Day and Night", "Alka-Seltzer Plus Severe Cough Mucus and Congestion Day and Night", "Alka-Seltzer Plus Severe Cough Mucus and Congestion Day and Night", "Alka-Seltzer Plus Severe Cough Mucus and Congestion Liquid Gels", "Alka-Seltzer Plus Severe Sinus and Cold", "Alka-Seltzer Plus Severe Sinus Cold and Cough Liquid Gels", "Alka-Seltzer Plus Severe Sinus Congestion Allergy and Cough", "Alka-Seltzer Plus Severe Sinus Congestion and Cough", "Alka-Seltzer Plus Severe Sinus Congestion and Cough Day and Night", "Alka-Seltzer Plus Severe Sinus Congestion and Cough Day and Night", "Alka-Seltzer Plus Severe Sinus Congestion and Cough Day and Night", "Alka-Seltzer Plus Severe Sinus Congestion and Cough Day and Night", "Alka-Seltzer Plus Severe Sinus Congestion and Cough Liquid Gels", "Alka-Seltzer Plus Severe Sinus Congestion and Cough Liquid Gels Day", "Alka-Seltzer Plus Severe Sinus Congestion and Cough Liquid Gels Night", "Alka-Seltzer Plus Severe Sinus Congestion, Allergy and Cough", "Alka-Seltzer Plus Severe Sinus Cough and Cold", "Alka-Seltzer Plus-D Multi-Symptom Sinus and Cold", "All Nite", "All-Nite Cold and Flu", "All-Nite Cold and Flu", "Allergy and Cough", "Allfen DM", "Allpanto S", "Alticotron", "Altidesp", "Altidome DMX", "Altilan CL", "Altipres", "Altipres Pediatric", "Altipres-B", "Altituss", "Always Save Chest Congestion Relief DM", "Amazon Basic Care Mucus DM", "Ampigrin Ultra Forte Night", "Antigrip", "ANTIGRIP Daytime", "ANTIGRIP Nighttime", "Antitussive Decong Antihistamine Syr", "AP-Hist DM", "Aquanaz", "Aquanaz PSE", "Aramark Multi-Symptom Cold Relief", "ASP Daytime PE", "ASP Nighttime Max", "Aspire Congestion and Cough Relief DM Softgels", "Aspire Day Congestion and Headache Softgel", "Aspire Daytime Mucus and Sinus Softgel", "Aspire Night Cold and Flu Softgel", "Aspirin Free Cold Head Congestion Day Time", "Assured Childrens Cold and Cough", "Assured Day time Cold and Cough", "Assured Maximum Strength Mucus Relief", "Atuss DS Tannate Suspension", "Auro Mucus - Childrens Cold, Cough and Sore Throat", "Auroflu Day Time Severe Cold and Cough", "AuroFlu Day Time Severe Cold and Cough Warming Relief", "AuroMucus - Childrens Cough", "AuroMucus - Childrens Multi-Symptom Cold", "AuroMucus - Fast Maximum Cold, Flu and Sore Throat Relief", "AuroMucus - Fast Maximum DM MAX", "AuroMucus - Fast Maximum Severe Congestion and Cough", "AuroMucus - Fast Maximum Severe Congestion and Cough", "Aurophen Cold and Flu Severe", "Aurophen Cold Multi Symptom", "Aurophen Cold Multi Symptom", "Aurophen Cold Multi-Symptom Severe", "AuroQuil COLD and FLU Day Time Multi-Symptom Relief", "AuroQuil COLD and FLU Nighttime Relief", "AuroQuil Cold and Flu Nighttime Relief", "AuroQuil Cough Nighttime Cough Relief", "AuroQuil Severe Cold and Flu Daytime Relief", "AuroQuil Severe Cold and Flu Nighttime Relief", "Aurotussin Maximum Strength Daytime and Nighttime Cough Relief", "Aurotussin Maximum Strength Daytime and Nighttime Cough Relief", "Aurotussin Peak Cold Cough plus Chest Congestion DM", "Aurotussin Peak Cold Maximum Strength Cough plus Chest Congestion DM", "Aurotussin Peak Cold Maximum Strength Multi-Symptom Cold", "Aurotussin Peak Cold Multi-Symptom Cold", "Aurotussin Peak Cold sugar-free COUGH PLUS CHEST CONGESTION DM", "Auvelity", "AXIM DayTime", "AXIM DayTime - Night Time 48 Softgels", "AXIM DayTime - Night Time 48 Softgels", "AXIM DayTime - Night Time 72 Softgels", "AXIM DayTime - Night Time 72 Softgels", "Axim Night Time", "Bactimicina Childrens Cough and Cold", "Bactimicina Cough and Cold", "Baczol Cold Medicine", "Baczol Cold Medicine", "Balahist DM Syrup", "Balamine DM Syrup", "Balminil Cough and Flu", "Balminil DM", "Balminil DM (3mg/ml Sucrose Free)", "Balminil DM + Decongestant", "Balminil DM + Decongestant + Expectorant", "Balminil DM + Decongestant + Expectorant Extra Strength", "Balminil DM + Expectorant", "Balminil DM + Expectorant Extra Strength", "Balminil DM Children", "Balminil DM Pour Enfants Syr 7.5mg/5ml", "Balminil DM-D-E - Liq", "Balminil Night-time", "Basic Care Childrens Cold and Cough", "Basic Care childrens cold and cough and sore throat", "Basic Care Childrens Cold Plus Flu", "Basic Care Childrens Cough DM", "Basic Care Childrens Cough DM", "Basic Care Childrens Mucus Relief", "Basic Care Childrens Mucus Relief", "basic care cough DM", "Basic Care Cough DM", "Basic Care Cough DM", "Basic Care Day Time Cold and Flu Night Time Cold and Flu", "Basic Care Day Time Cold and Flu Night Time Cold and Flu", "Basic Care Day Time Night Time Cold and Flu", "Basic Care Day Time Night Time Cold and Flu", "Basic Care Daytime", "Basic Care Daytime Cold and Flu", "Basic Care Daytime Cold and Flu", "Basic Care Daytime Cold and Flu", "Basic Care Daytime Cold and Flu", "Basic Care Daytime Cold and Flu", "Basic Care Daytime Cold and Flu Nighttime Cold and Flu", "Basic Care Daytime Cold and Flu Nighttime Cold and Flu", "Basic Care Daytime Cold and Flu Severe", "Basic Care Daytime Nighttime Cold and Flu", "Basic Care Daytime Nighttime Cold and Flu", "Basic Care Daytime Nighttime Cold and Flu", "Basic Care Daytime Nighttime Cold and Flu", "Basic Care Daytime Nighttime Cold and Flu", "Basic Care Daytime Nighttime Cold and Flu", "Basic Care Daytime Nighttime Cold and Flu", "Basic Care Daytime Nighttime Cold and Flu", "Basic Care Daytime Nighttime Severe Cold and Flu", "Basic Care Daytime Nighttime Severe Cold and Flu", "Basic Care daytime nighttime severe cold and flu", "Basic Care daytime nighttime severe cold and flu", "Basic Care Daytime Nighttime Severe Cold and Flu", "Basic Care Daytime Nighttime Severe Cold and Flu", "Basic Care Daytime Nighttime Severe Cold and Flu", "Basic Care Daytime Nighttime Severe Cold and Flu", "Basic Care Daytime Nighttime Severe Cold and Flu", "Basic Care Daytime Nighttime Severe Cold and Flu", "Basic Care Daytime Severe Cold and Flu", "Basic Care Daytime Severe Cold and Flu", "Basic Care Daytime Severe Cold and Flu", "Basic Care Daytime Severe Cold and Flu", "Basic Care Daytime Severe Cold and Flu Nighttime Cold and Flu", "Basic Care Daytime Severe Cold and Flu Nighttime Cold and Flu", "Basic Care Daytime Severe Cold and Flu Nighttime Severe Cold and Flu", "Basic Care Daytime Severe Cold and Flu Nighttime Severe Cold and Flu", "Basic Care Daytime Severe Cold and Flu Nighttime Severe Cold and Flu", "Basic Care Daytime Severe Cold and Flu Nighttime Severe Cold and Flu", "Basic Care Daytime Severe Cold and Flu Nighttime Severe Cold and Flu", "Basic Care Daytime Severe Cold and Flu Nighttime Severe Cold and Flu", "Basic Care Daytime Severe Cold and Flu Nighttime Severe Cold Cough and Flu", "Basic Care Daytime Severe Cold and Flu Nighttime Severe Cold, Cough and Flu", "Basic Care Daytime Severe Cold Nighttime Cold and Flu", "Basic Care Daytime Severe Cold Nighttime Cold and Flu", "Basic Care Daytime Severe Cold Nighttime Cold and Flu", "Basic Care Mucus DM", "Basic Care Mucus DM", "Basic Care Mucus DM", "Basic Care Mucus DM", "Basic Care Mucus Relief Cold Flu and Sore Throat", "Basic Care Mucus Relief Severe Congestion and Cough", "Basic Care Night Time Cough", "Basic Care Nighttime", "Basic Care Nighttime Cold and Flu", "Basic Care Nighttime Cold and Flu", "Basic Care Nighttime Cold and Flu", "Basic Care Nighttime Cold and Flu", "Basic Care Nighttime Cold and Flu", "Basic Care Nighttime Cold and Flu", "Basic Care Nighttime Cold and Flu Severe", "Basic Care Nighttime Severe Cold and Flu", "Basic Care Nighttime Severe Cold and Flu", "Basic Care Nighttime Severe Cold and Flu", "Basic Care Nighttime Severe Cold and Flu", "Basic Care Nighttime Severe Cold and Flu", "Basic Care Severe Cold and Flu", "Basic Care Severe Cold and Flu", "Basic Care Tussin CF Severe", "Basic Care Tussin CF Severe", "Basic Care Tussin DM", "Basic Care Tussin DM", "Basic Care Tussin DM Max", "BC Daytime Multi-Symptom", "Being Well Adult Cough Relief DM", "Being Well Cold and Flu Relief PM", "Being Well Cold Flu Relief PM Multi Symptom", "Being Well Night Time Cold and Flu", "Benylin 1 Nightime With Menthactin", "Benylin 1 With Menthactin", "Benylin 4 Flu - Syrup", "Benylin All-IN-one Cold & Flu Daytime", "Benylin All-IN-one Cold & Flu Nighttime", "Benylin All-IN-one Cold and Flu PE Caplets", "Benylin All-IN-one Cold, Flu & Cough Liquid Gels", "Benylin Cough & Congestion Extra Strength", "Benylin Cough and Cold", "Benylin Cough and Congestion", "Benylin Cough Plus Cold Relief", "Benylin DM 12 Hour Syrup", "Benylin DM Extra Strength Lozenges", "Benylin DM Freezer Pops", "Benylin DM Liquid Centre Lozenges", "Benylin DM Liquid Centre Lozenges Extra Strength", "Benylin DM Lozenges", "Benylin DM Lozenges Extra Strength", "Benylin DM Pocketpaks", "Benylin DM Strips", "Benylin DM With Pectin Freezer Pops", "Benylin DM-D", "Benylin DM-D", "Benylin DM-D Chewables for Children", "Benylin DM-D for Children", "Benylin DM-D for Infants", "Benylin DM-D for Infants", "Benylin DM-D Soft Chews With Menthactin", "Benylin DM-D With Menthactin", "Benylin DM-D-AH Chewables for Children", "Benylin DM-D-AH for Children", "Benylin DM-D-E", "Benylin DM-D-E Extra Strength With Menthactin", "Benylin DM-D-E With Menthactin", "Benylin DM-D-E-A Cold and Sinus Liquid Gels", "Benylin Extra Strength All-IN-one Cold and Flu", "Benylin Extra Strength All-IN-one Cold and Flu Nightime", "Benylin Extra Strength All-IN-one Cold, Flu & Cough", "Benylin Extra Strength All-IN-one Cough, Cold & Flu", "Benylin Extra Strength All-IN-one Cough, Cold & Flu Night", "Benylin Extra Strength All-IN-one Cough, Cold & Flu With Warming Sensation", "Benylin Extra Strength Cough & Chest Congestion", "Benylin Extra Strength Cough & Chest Congestion With Warming Sensation", "Benylin Extra Strength Cough Complete", "Benylin Extra Strength Dry Cough", "Benylin Extra Strength for People With Diabetes", "Benylin Extra Strength Mucus & Phlegm Plus Cold Relief", "Benylin Extra Strength Mucus & Phlegm Plus Cold Relief", "Benylin Extra Strength Mucus & Phlegm Plus Cold Relief Night", "Benylin Extra Strength Mucus & Phlegm Plus Cough Control", "Benylin Extra Strength With Menthactin", "Benylin for Children All-IN-one Cold & Fever", "Benylin for Children All-IN-one Cold & Fever Nightime", "Benylin for Children All-IN-one Cold and Fever", "Benylin for Children Cough & Cold", "Benylin for Children Cough Stuffy and Runny Nose", "Benylin for Children DM 12 Hour Syrup", "Benylin for Children Dry Cough", "Benylin Regular Strength Cough Plus Chest Congestion Relief", "Benylin Tickly Throat Cough", "Berkley and Jensen Adult Tussin DM", "Berkley and Jensen Mucus Relief DM", "Berkley and Jensen Tussin Cough and Chest Congestion DM", "Berkley and Jensen Tussin DM", "Berkley Jensen Tussin", "Berro y Cebolla DM", "Best Choice Daytime Severe Cold and Cough Berry infused with Menthol and Green Tea flavors", "BestHealth Cough Relief Honey Lemon Flavor", "BestHealth Cough Relief Sugar Free Cherry Flavor", "Betr Cold and Flu Daytime Relief", "Betr Cold and Flu Nighttime Relief", "BIO Dtuss DMX", "Bio T Pres-B", "Bio-B Kids", "Bio-G-Tuss Pediatric Drops", "Bio-rytuss", "Bio-S-Pres DX", "Bio-Z-Cough", "Biobron DX", "Biobron SF", "Biocof", "Biocotron", "Biocotron PED", "Biocotron-D", "Biodesp DM", "Biodesp DM NF", "BioGtuss", "BioGtuss NF", "Biogtuss TR", "Biohisdex DM Decongestant", "Biohisdine DM Decongestant", "Bionatuss DXP", "Bionel", "Bionel Pediatric", "Biospec DMX", "Biospec DMX", "BioTPres", "BioTPres Pediatric", "Bisolvine Adult", "Bisolvine Adult", "Bisolvine Adult", "Bisolvine Aloe-Miel", "Bisolvine Child", "Bisolvine Children", "BP8 Cough", "BPM Mal Phenyleph HCl DM HBr", "Bpm-DM-phen", "BranTussin DM", "Breacold Adult", "Breacold Children", "Brom Mal Phenyl HCl Dex HBr", "Brom Tapp DM", "Brom/PSE/DM Cough", "Bromdex D", "Bromfed DM", "Bromfed DM", "Bromfed DM", "Bromfed DM", "BromfedDM DM", "Bromhist PDX", "Bromphenex DM", "Brompheniramine Maleate, Pseudoephedrine Hydrochloride and Dextromethorphan Hydrobromide", "Brompheniramine Maleate, Pseudoephedrine Hydrochloride and Dextromethorphan Hydrobromide", "Brompheniramine Maleate, Pseudoephedrine Hydrochloride and Dextromethorphan Hydrobromide", "Brompheniramine Maleate, Pseudoephedrine Hydrochloride and Dextromethorphan Hydrobromide", "Brompheniramine Maleate, Pseudoephedrine Hydrochloride and Dextromethorphan Hydrobromide", "Brompheniramine Maleate, Pseudoephedrine Hydrochloride and Dextromethorphan Hydrobromide", "Brompheniramine Maleate, Pseudoephedrine Hydrochloride and Dextromethorphan Hydrobromide", "Brompheniramine Maleate, Pseudoephedrine Hydrochloride and Dextromethorphan Hydrobromide", "Brompheniramine Maleate, Pseudoephedrine Hydrochloride and Dextromethorphan Hydrobromide", "Brompheniramine Maleate, Pseudoephedrine Hydrochloride and Dextromethorphan Hydrobromide", "Brompheniramine Maleate, Pseudoephedrine Hydrochloride and Dextromethorphan Hydrobromide", "Brompheniramine Maleate, Pseudoephedrine Hydrochloride and Dextromethorphan Hydrobromide", "Brompheniramine Maleate, Pseudoephedrine Hydrochloride and DextromethorphanHydrobromide", "Brompheniramine maleate, pseudoephedrine hydrochloride,", "Brompheniramine maleate, pseudoephedrine hydrochloride,", "Brompheniramine Maleate, Pseudoephedrine Hydrochloride, and Dextromethorphan Hydrobromide", "Brompheniramine Maleate, Pseudoephedrine Hydrochloride, and Dextromethorphan Hydrobromide", "Brompheniramine Maleate, Pseudoephedrine Hydrochloride, and Dextromethorphan Hydrobromide", "Brompheniramine Maleate, Pseudoephedrine Hydrochloride, and Dextromethorphan Hydrobromide", "Brompheniramine Maleate, Pseudoephedrine Hydrochloride, and Dextromethorphan Hydrobromide", "Brompheniramine Maleate, Pseudoephedrine Hydrochloride, and Dextromethorphan Hydrobromide", "Brompheniramine Maleate, Pseudoephedrine Hydrochloride, and Dextromethorphan Hydrobromide", "Brompheniramine Maleate, Pseudoephedrine Hydrochloride, and Dextromethorphan Hydrobromide", "Brompheniramine Maleate, Pseudoephedrine Hydrochloride, and Dextromethorphan Hydrobromide", "Brompheniramine Maleate, Pseudoephedrine Hydrochloride, and Dextromethorphan Hydrobromide", "Brompheniramine Maleate, Pseudoephedrine Hydrochloride, and Dextromethorphan Hydrobromide", "Brompheniramine Maleate, Pseudoephedrine Hydrochloride, and Dextromethorphan Hydrobromide", "Brompheniramine Maleate, Pseudoephedrine Hydrochloride, and Dextromethorphan Hydrobromide", "Brompheniramine Maleate, Pseudoephedrine Hydrochloride, and Dextromethorphan Hydrobromide", "Brompheniramine Maleate, Pseudoephedrine Hydrochloride, Dextromethorphan Hydrobromide", "Brompheniramine Maleate, Pseudoephedrine Hydrochloride, Dextromethorphan Hydrobromide", "Brompheniramine Maleate, Pseudoephedrine Hydrochloride, Dextromethorphan Hydrobromide", "Brompheniramine Maleate, Pseudoephedrine Hydrochloride, Dextromethorphan Hydrobromide", "Brompheniramine Maleate, Pseudoephedrine Hydrochloride, Dextromethorphan Hydrobromide", "Brompheniramine Phenylephrine DM", "Brompheniramine Pseudoephedrine DM", "Brompheniramine, Pseudoephedrine, Dextromethorphan", "Broncho-grippol-DM", "Bronchodex Fort-DM Syr", "Bronchodex Pediatrique", "Bronchophan Forte DM Syr", "Bronchosirum Pour Enfants", "Bronco Pulmonar Syrup", "Bronco Silen-DM", "Bronco-Flu Des", "Bronco-Flu Plus", "Broncochem Cold and Flu Caplets", "Broncochem Expectorant II", "Broncochem Kids Allergy Control", "Broncochem Maximum Cough", "Broncochem Maximum Cough Kids", "Broncofin", "Broncolin Cold and Flu Relief", "Broncomar", "Broncomar DM", "Broncomar DM", "Broncomar EXPECTORANT", "Broncomar Maximum", "Broncomar Maximun Cough Relief", "Broncotron", "Broncotron D", "Broncotron PED", "Broncotron PED", "Broncotron S", "Bronkids", "Bronkids", "Bronkids", "Bronkisan", "Brontuss", "Brontuss DX", "Brontuss SF", "Brontuss SF-NR", "Brotapp DM Cold and Cough", "Brotapp PE-DM Cough and Cold", "BroveX PEB DM", "BroveX PSB DM", "Buckley's Cold & Sinus 24 Hour Pack", "Buckley's Cold & Sinus 24 Hour Pack", "Buckley's Complete + Mucus Relief", "Buckley's Complete 24 Hour Pack", "Buckley's Complete 24 Hour Pack", "Buckley's Complete Cough, Cold & Flu Day", "Buckley's Complete Daytime Softgels", "Buckley's Complete Extra Strength Cough, Cold & Flu Day", "Buckley's Complete Extra Strength Cough, Cold and Flu Night", "Buckley's Complete Nighttime Softgels", "Buckley's Complete Relief", "Buckley's Complete Relief + Mucus", "Buckley's DM", "Buckley's DM Decongestant", "Buckley's Dry Cough Extra Strength", "Buckley's Nighttime Cold and Sinus", "Buckleys Cold & Sinus", "Cabinet Cough Relief", "Calmadol Plus", "Calmylin #2 Syr", "Calmylin #3 Syr", "Calmylin #4 Syr", "Calmylin Cough and Flu Liq", "Calmylin No. 1 Syr 15mg/5ml", "Calmylin Pediatric Syrup", "Capmist DM", "Capmist DM", "Capron DM", "Capron DMT", "Carbinoxamine/Pseudoephedrine/DM", "Carbofed DM", "Cardec DM", "Care One Chest Congestion Relief DM", "Care One Chest Congestion Relief DM", "Care One Cold Head Congestion", "Care One Cold Head Congestion", "Care One Cold Head Congestion", "Care One cold head congestion", "Care One Cold Head Congestion daytime non-drowsy", "Care One Cold Multi Symptom", "Care One Cold Multi Symptom", "Care One Cold Multi Symptom", "Care One Cold Multi Symptom", "Care One Cold Mutli Symptom", "Care One Flu and Severe Cold and Cough Daytime", "CareOne Adult Tussin CF", "CareOne Adult Tussin DM", "CareOne Adult Tussin DM", "CareOne Adult Tussin DM sugar free", "Careone Allergy and Cough Severe Sinus Congestion", "CareOne Childrens Cold and Cough", "CareOne Childrens Cold and Flu", "CareOne Childrens Mucus Relief", "Careone Childrens Mucus Relief", "Careone Childrens Multi Symptom Fever and Cold", "CareOne Cold and Cough", "CareOne Cold Flu and sore throat", "Careone Cold Max", "CareOne Cold plus Flu Severe", "CareOne Cough DM", "CareOne Cough DM", "Careone Day Cold and Flu Night Cold and Flu", "Careone Day Cold and Flu Night Cold and Flu", "Careone Day Severe Cold Night Cold and Flu", "Careone Day Severe Cold Night Cold and Flu", "CareOne Day Time Severe Cold Night Time Cold and Flu", "CareOne DayTime Cold and Flu", "CareOne Daytime Cold Flu Relief", "CareOne Daytime Nighttime Cold and Flu", "CareOne Daytime Nighttime Cold and Flu", "CareOne Daytime Nighttime Cold Flu Relief", "CareOne Daytime Nighttime Cold Flu Relief", "Careone Daytime Nighttime Severe Cold and Flu", "Careone Daytime Nighttime Severe Cold and Flu", "Careone Daytime Severe Cold and Cough", "CareOne Daytime Severe Cold and Cough Berry infused with Menthol and Green Tea flavors", "Careone daytime severe cold and flu", "Careone Daytime Severe Cold Flu Relief", "CareOne Mucus Relief", "CareOne Mucus Relief", "CareOne Mucus Relief DM", "CareOne Mucus Relief Severe Congestion and Cold", "CareOne Night TIme Cold and Flu", "CareOne Nighttime Cold and Flu", "CareOne NightTime Cough", "CareOne Nighttime Severe Cold and Flu", "CareOne Nitetime Cold Flu Relief", "CareOne Nitetime Cold Flu Relief", "CareOne Nitetime Severe Cold Flu Relief", "CareOne Severe Cold", "Careone Severe Sinus Congestion", "Careone Tussin", "CareOne Tussin CF Multi Symptom Cold", "Careone Tussin DM", "Careone Tussin DM", "Careone Tussin DM", "CareOne Tussin DM cough plus chest congestion", "CareOne Tussin DM cough plus chest congestion", "CareOne Tussin DM cough plus chest congestion", "CareOne Tussin DM Nighttime Cough", "Carepanto", "Caring Mill Adult Tussin", "Caring Mill Childrens Cold and Cough", "Caring Mill Childrens Cough DM", "Caring Mill Childrens Mucus Relief", "Caring Mill Daytime", "Caring Mill Daytime Cold and Flu", "Caring Mill Mucus DM", "Caring Mill Nighttime", "Caring Mill Nighttime Cold and Flu", "Centracol DM - Syr", "Centracol Pediatrique - Syr", "Cepacol Extra Strength Sore Throat and Cough", "Cepacol Extra Strength Sore Throat mixed berry", "Cepacol SORE THROAT AND COUGH", "Cepacol Sore Throat and Cough", "Cepacol Sore Throat and Cough", "Cepacol Sore Throat Plus Cough", "CEPASTAT Sore throat and Cough", "Ceron DM", "Cetafen Cough and Cold", "CETAFEN COUGH and COLD", "Cheracol D Cough Formula 4oz", "Chest Congestion and Cough HBP", "Chest Congestion and Cough HBP", "Chest Congestion Childrens Plus Cough", "Chest Congestion Relief", "Chest Congestion Relief", "Chest Congestion Relief DM", "Chest Congestion Relief DM", "Chest Congestion Relief DM", "Children Cough and Cold", "Children's Cough & Cold Relief", "Children's Cough & Cold Relief", "Children's Cough Strips", "Children's Cough Syrup", "Children's Nicold Medicine", "Children's Nyquil Liquid", "Children's Tussin Cough Medicine DM Antitussive Decongestant", "Children's Tylenol Cold and Cough", "Children's Tylenol Cold and Cough", "Children's Tylenol Cold and Cough", "Children's Tylenol Cold and Cough", "Children's Tylenol Cold and Cough Nighttime", "Children's Tylenol Cold Liquid With DM", "Children's Tylenol Complete Cold, Cough & Fever", "Children's Tylenol Complete Cold, Cough & Fever Nighttime", "Children's Tylenol Cough and Runny Nose", "Childrens Aurotussin Cough and Chest Congestion DM", "Childrens Aurotussin Cough and Cold CF", "Childrens Cold and Cough", "Childrens Cold and Cough", "Childrens Cold and Cough", "Childrens Cold and Cough", "Childrens Cold and Cough", "Childrens Cold and Cough", "Childrens Cold and Cough Relief", "Childrens Cold and Flu", "Childrens Cold, Cough and Sore Throat", "Childrens Cold, Cough and Sore Throat", "Childrens Cough", "Childrens Cough and Chest Congestion DM", "Childrens Cough and Chest Congestion DM", "Childrens Cough and Chest Congestion DM", "Childrens Cough and Cold", "Childrens Cough and Cold", "Childrens Cough and Cold CF", "Childrens Cough and Cold CF", "Childrens Cough and Sore Throat", "Childrens Cough DM", "Childrens Cough DM", "Childrens Cough Mucus Relief", "Childrens Cough Plus Sore Throat", "Childrens Cough Relief", "Childrens Cough Relief", "Childrens Day Time Cold and Cough", "Childrens Daytime Cold and Cough", "Childrens Daytime Cold and Cough", "Childrens Daytime Cold and Cough", "Childrens Delsym Cough Plus Chest Congestion DM", "Childrens Delsym Cough Plus Chest Congestion DM and Delsym Cough Plus Cold Night Time", "Childrens Delsym Cough Plus Cold Day Time", "Childrens Delsym Cough Plus Sore Throat", "Childrens Dibromm Cold and Cough", "Childrens Dibromm Cold and Cough", "Childrens Dimetapp Cold and Cough", "Childrens Dimetapp Cold and Cough", "Childrens Dimetapp Cold and Cough", "Childrens Dimetapp Long Acting Cough Plus Cold", "Childrens Dimetapp Multi-Symptom Cold Relief Dye-Free", "Childrens Dimetapp Multisymptom Cold and Flu", "Childrens Flu Relief", "Childrens Giltuss Honey Cough and Chest Congestion", "Childrens Giltuss Honey DM Cough", "Childrens HoneyWorks Plus Nighttime Cough Syrup", "Childrens Metapp Daytime", "Childrens Mucinex Cold, Cough and Sore Throat", "Childrens Mucinex Congestion and Cough", "Childrens Mucinex Congestion and Cough", "Childrens Mucinex Cough", "Childrens Mucinex Cough", "Childrens Mucinex Cough", "Childrens Mucinex Cough", "Childrens Mucinex Mini-Melts Cough", "Childrens Mucinex Multi Symptom Cold and Childrens Mucinex Night Time Multi Symptom Cold", "Childrens Mucinex Multi-Symptom Cold", "Childrens Mucinex Multi-Symptom Cold", "Childrens Mucinex Multi-Symptom Cold and Fever", "Childrens Mucus and Cough Relief", "Childrens Mucus and Cough Relief", "Childrens Mucus and Cough Relief", "Childrens Mucus Cough and Congestion Relief", "Childrens Mucus Relief", "Childrens mucus relief", "Childrens Mucus Relief", "Childrens mucus relief", "Childrens Mucus Relief", "Childrens Mucus Relief Cherry", "Childrens Mucus Relief Chest Congestion Plus Cough", "Childrens Mucus Relief Chest Congestion Plus Cough", "Childrens Mucus Relief COUGH", "Childrens Mucus Relief cough", "Childrens Mucus Relief Cough", "Childrens Mucus Relief Cough Cherry", "Childrens Mucus Relief Cough Cherry", "Childrens Mucus Relief Cough Cherry Liquid", "Childrens Mucus Relief Cough, Cold and Sore Throat", "Childrens Mucus Relief DM", "Childrens Mucus Relief Multi Symptom Cold", "Childrens Mucus Relief Multi Symptom Cold", "Childrens mucus relief multi-symptom cold", "Childrens Multi Symptom Cold", "Childrens Multi Symptom Cold", "Childrens Multi Symptom Cold", "childrens Multi Symptom Fever and Cold", "Childrens Multi Symptom Fever and Cold", "Childrens Multi Symptom Fever and Cold", "Childrens Multi-Symptom Cold", "Childrens Multi-symptom Cold", "Childrens Multi-symptom Cold", "Childrens Multi-symptom Cold and Fever Liquid", "Childrens Multi-Symptom Cold and Fever Relief", "Childrens Multi-Symptom Cold Plus Dye-Free", "Childrens Novex Cold Plus Cough Plus Sore Throat", "Childrens Pain Relief Cold and Cough and Sore Throat", "Childrens Pain Relief Cold and Flu", "Childrens Pain Relief Plus Cough and Sore Throat", "Childrens Pain Relief Plus Multi Symptom Cold", "Childrens Plus Cough and Runny Nose", "Childrens Plus Cough and Runny Nose", "Childrens Plus Cough and Runny Nose", "Childrens Plus Cough and Runny Nose", "Childrens Plus Cough and Runny Nose", "Childrens Plus Cough and Runny Nose", "Childrens Plus Cough and Runny Nose", "Childrens Plus Cough and Runny Nose", "Childrens Plus Cough and Runny Nose", "Childrens Plus Cough and Runny Nose", "Childrens Plus Cough and Runny Nose", "Childrens Plus Cough and Runny Nose", "Childrens Plus Cough and Runny Nose", "Childrens Plus Cough and Runny Nose", "Childrens Plus Cough and Runny Nose", "Childrens Plus Cough and Runny Nose", "Childrens Plus Cough and Sore Throat", "Childrens Plus Cough and Sore Throat", "Childrens Plus Flu", "Childrens Plus Flu", "Childrens Plus Flu", "Childrens Plus Flu with PE", "Childrens Plus Multi Symptom Cold", "Childrens Plus Multi Symptom Cold", "Childrens Plus Multi Symptom Cold", "Childrens Plus Multi Symptom Cold", "Childrens Plus Multi Symptom Cold", "Childrens Plus Multi Symptom Cold", "Childrens Plus Multi Symptom Cold", "Childrens Plus Multi Symptom Cold", "Childrens Plus Multi Symptom Cold", "Childrens Plus Multi Symptom Cold Dye Free", "Childrens Plus Multi Symptom Cold DYE FREE", "Childrens Plus Multi-Symptom Cold Grape with PE", "Childrens Plus Multi-Symptom Cold Grape with PE", "Childrens Plus Multi-Symptom Cold Grape with PE", "Childrens Plus Multi-Symptom Cold Grape with PE", "Childrens Plus Multi-Symptom Cold Grape with PE", "Childrens Plus Multi-Symptom Grape with PE", "Childrens Plus Multi-Symptom with PE", "Childrens Relief Cherry", "Childrens Robitussin 12 Hour Cough Relief", "Childrens Robitussin 12 Hour Cough Relief", "Childrens Robitussin Cough and Chest Congestion DM", "Childrens Robitussin Cough and Chest Congestion DM", "Childrens Robitussin Cough and Cold CF", "Childrens Robitussin Cough and Cold Long-acting", "Childrens Robitussin Cough Long-Acting", "Childrens Robitussin Elderberry Cough and Chest Congestion DM", "Childrens Robitussin Honey Cough and Chest Congestion DM", "Childrens Robitussin Honey Nighttime Cough DM", "Childrens Robitussin Nighttime Cough Long-Acting DM", "Childrens SUDAFED PE Cold plus Cough", "Childrens Tukol Multi-Symptom Cold and Flu", "Childrens Tussin DM", "Childrens Tussnex", "Childrens Tussnex Multi-symptom cold", "Childrens TYLENOL COLD plus COUGH plus RUNNY NOSE", "Childrens TYLENOL COLD PLUS COUGH PLUS SORE THROAT", "Childrens TYLENOL COLD Plus FLU", "Childrens TYLENOL COLD Plus FLU", "CHILDRENS TYLENOL PLUS COUGH and SORE THROAT", "Childrens Tylenol Plus Flu", "Childrens Tylenol Plus Multi-Symptom Cold", "Childrens Tylenol Plus Multi-Symptom Cold", "Childrens Wal Tap DM", "Childrens Wal Tap DM Cough and Cold", "childrens Wal Tussin Cough and Cold", "Chloraseptic Total Sore Throat and Cough", "Chloraseptic Total Sore Throat and Cough, Sugar Free", "Chloresin", "Chlorphen Mal Dex HBr Pseudoeph HCl", "Circle K Cold", "Circle K Cold", "Circle K Daytime Cold and Flu", "Circle K Daytime Cold and Flu", "Circle K Daytime Cold and Flu", "Circle K Daytime Cold and Flu", "Circle K Daytime Cold and Flu", "Circle K Daytime Cold and Flu", "Circle K Daytime Cold and Flu", "Circle K Daytime Cold and Flu", "Circle K Daytime Cold and Flu", "Circle K Daytime Cold and Flu", "Circle K Daytime Cold and Flu", "Circle K Nighttime Cold and Flu", "Circle K Nighttime Cold and Flu", "Circle K Nighttime Cold and Flu", "Circle K Nighttime Cold and Flu", "Circle K Nighttime Cold and Flu", "Circle K Nighttime Cold and Flu", "Circle K Nighttime Cold and Flu", "Circle K Nighttime Cold and Flu", "Circle K Nighttime Cold and Flu", "Circle K Nighttime Cold and Flu", "Citron Chaud DM Cumberland Pws", "Citron Chaud DM Option + Pws", "Citron Chaud Réguliern DM", "Codituss DM", "Colcol-S", "Cold", "Cold", "Cold", "Cold", "Cold", "Cold", "Cold", "Cold & Cough", "Cold & Cough Extra Strength", "Cold & Flu", "Cold & Flu", "Cold & Flu", "Cold & Flu Daytime", "Cold & Flu Nighttime", "Cold & Flu Relief Nighttime", "Cold & Flu-IN-one", "Cold & Sinus Liquid Capsules", "Cold & Sinus Liquid Capsules", "Cold & Sinus Liquid Fastgels", "Cold and Cough", "Cold and Cough", "Cold and Cough", "Cold and Cough", "Cold and Cough", "Cold and Cough", "Cold and Cough", "Cold and Cough", "Cold and Cough", "Cold and Cough", "Cold and Cough", "Cold and Cough childrens", "Cold and Cough Childrens", "Cold and Cough Childrens", "Cold and Cough Childrens", "Cold and Cough Day Time Childrens", "Cold and Cough Daytime", "Cold and Cough DM", "Cold and Cough High Blood Pressure", "Cold and Cough MULTI-SYMPTOM DAYTIME / NIGHTTIME", "Cold and Cough Nighttime", "Cold and Cough Nighttime Cool Blast", "Cold and Cough PE", "Cold and Cough Relief children", "Cold and Cough Relief Extra Strength", "cold and cough sinus relief PE NON-DROWSY", "Cold and Flu", "Cold and Flu", "Cold and Flu", "Cold and Flu", "Cold and Flu", "Cold and Flu", "Cold and Flu", "Cold and Flu", "Cold and Flu", "COLD and FLU", "COLD and FLU", "Cold and Flu", "Cold and Flu", "Cold and Flu", "Cold and Flu", "Cold and Flu", "Cold and Flu", "Cold and Flu", "Cold and Flu", "Cold and Flu All In One", "Cold and Flu Capsules", "Cold and Flu Day", "Cold and Flu Day and Night, Severe", "Cold and Flu Day and Night, Severe", "Cold and Flu Day Night", "Cold and Flu Day Night", "Cold and Flu Day Time Multi-Symptom Relief", "COLD and FLU Day Time Multi-Symptom Relief", "COLD and FLU Day Time Multi-Symptom Relief", "Cold and Flu Day, Night", "Cold and Flu Day, Night", "Cold and Flu Daytime", "Cold and Flu Daytime", "Cold and Flu DayTime", "Cold and Flu DayTime", "Cold and Flu DayTime", "Cold and Flu Daytime", "Cold and Flu Daytime", "Cold and Flu DayTime", "Cold and Flu daytime", "Cold and Flu Daytime", "Cold and Flu Daytime", "Cold and Flu Daytime", "Cold and Flu Daytime", "Cold and Flu Daytime", "Cold and Flu Daytime", "Cold and Flu Daytime", "COLD and FLU DAYTIME MAXIMUM STRENGTH NON-DROWSY SEVERE", "COLD and FLU DAYTIME MAXIMUM STRENGTH NON-DROWSY SEVERE", "COLD and FLU DAYTIME MAXIMUM STRENGTH NON-DROWSY SEVERE", "Cold and Flu Daytime Nighttime", "Cold and Flu Daytime Nighttime", "Cold and Flu Daytime Nighttime", "Cold and Flu Daytime Nighttime", "Cold and Flu Daytime Nighttime", "Cold and Flu Daytime Nighttime", "Cold and Flu Daytime Relief", "Cold and Flu Daytime Relief", "Cold and Flu Daytime Relief", "Cold and Flu DayTime Relief", "Cold and Flu Daytime Severe", "Cold and Flu Daytime Severe", "Cold and Flu Daytime Severe", "Cold and Flu Daytime Severe, 24/7 Life", "Cold and Flu Daytime Severe, Nighttime Severe", "Cold and Flu Daytime Severe, Nighttime Severe", "Cold and Flu Daytime-nighttime", "Cold and Flu Daytime-nighttime", "Cold and Flu Daytime, Nighttime", "Cold and Flu Daytime, Nighttime", "Cold and Flu Daytime, Nighttime", "Cold and Flu Daytime, Nighttime", "Cold and Flu Daytime, Nighttime", "Cold and Flu 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Multi-Symptom", "Cold, Flu and Sore Throat Maxium Strength", "Cold, Flu and Sore Throat Multi-Symptom", "Cold, Flu and Sore Throat Relief Maximum Strength, Multi Symptom", "Cold, Flu and Sore Throat Relief Maximum Strength, Multi Symptom", "Cold, Flu, and Sore Throat", "Cold, Flu, and Sore Throat", "Cold, Flu, and Sore Throat", "Cold,sore Throat Pain & Cough Ultra Strength", "Cold/flu Medicine", "Cold/Flu Multi-Symptom Relief Daytime/Nighttime", "Cold/flu Relief", "Coldaside Cold & Flu Extra Strength", "Coldaside Cough & Cold", "Colds & Coughs", "COLDTAC Plus", "COLDTAC Plus", "Coldtac Plus Softgels", "Coltalin-DM", "Complete", "Complete", "Complete Cold & Flu Relief", "Complete Cold Relief", "Complete Cold Relief", "Complete Daytime", "Complete Daytime Liquid Capsules", "Complete Liquid Capsules", "Complete Liquid Capsules", "Complete Liquid Capsules Nighttime Relief", "Complete One Cold and Flu Extra Strength", "Complete One Cold and Flu Extra Strength Tablets", "Complete One Cold and Flu Nightime Extra Strength Liquid", "Comtrex Cough and Cold Day/Night", "Comtrex Cough and Cold Day/Night", "COMTREX Maximum Strength Cold and Cough Non-Drowsy", "Congestion and Cough Childrens", "Congestion and Headache", "ConRx Cold", "ConRx Cold", "ConRX DayTime", "ConRx NightTime", "Contac Cold and Flu Cooling Relief", "Contac Cold and Sore Throat Caplets", "Contac Cold Nasal Congestion-nighttime", "Contac Complete Cough, Cold & Flu Syrup", "Contac Cough & Cold Syrup", "Contac Cough and Sore Throat Syrup", "Contac Cough Cold and Flu Caplets", "Contac Cough Syrup", "Contac Night Cough Syrup", "Cooling Severe Daytime", "Cooling Severe Daytime", "Cooling Severe Daytime Cooling Severe Nighttime", "Cooling Severe Daytime Cooling Severe Nighttime", "Cooling Severe Daytime Cooling Severe Nighttime", "Cooling Severe Daytime Cooling Severe Nighttime", "Cooling Severe Nighttime", "Cooling Severe Nighttime", "Core Values Night Time Relief", "Core Values Tussin CF", "Core Values Tussin DM", "Corfen DM", "Corfen DM", "Coricidin Cold & Flu Extra Strength", "Coricidin Cold & Flu Liquid Gels", "Coricidin Cold & Flu Multi-symptom", "Coricidin Complete Cold, Cough & Flu", "Coricidin Cough & Cold", "Coricidin HBP Chest Congestion And Cough", "Coricidin HBP Cough and Cold", "Coricidin HBP Cough and Cold", "Coricidin HBP Cough and Cold Cough Suppressant, Antihistamine", "Coricidin HBP Cough and Cold Cough Suppressant, Antihistamine", "Coricidin HBP Day and Night", "Coricidin HBP Day and Night", "Coricidin HBP Maximum Strength Cold and Flu Day and Night", "Coricidin HBP Maximum Strength Cold and Flu Day and Night", "Coricidin HBP Maximum Strength Cold and Flu Day and Night", "Coricidin HBP Maximum Strength Cold, Cough and Flu", "Coricidin HBP Maximum Strength Cold, Cough and Flu", "Coricidin HBP Maximum Strength Cold, Cough and Flu", "Coricidin HBP Maximum Strength Flu", "Coricidin HBP Maximum Strength Multi Symptom Flu", "Coricidin HBP Maximum Strength Nighttime Cold and 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Symptom Cold and Flu Relief", "Daytime Nighttime Multi Symptom Cold and Flu Relief", "DayTime Nighttime multi symptom cold and flu relief", "DayTime Nighttime multi symptom cold and flu relief", "Daytime Nighttime Multi Symptom Cold Childrens", "Daytime Nighttime Multi Symptom Cold Flu Relief", "Daytime Nighttime Multi Symptom Cold Flu Relief", "Daytime Nighttime Severe Cold", "Daytime Nighttime Severe Cold and Flu", "Daytime Nighttime Severe Cold and Flu", "Daytime Nighttime Severe Cold and Flu", "Daytime Nighttime Severe Cold and Flu", "Daytime Nighttime Severe Cold and Flu", "Daytime Nighttime Severe Cold and Flu", "Daytime Nighttime Severe Cold and Flu", "DAYTIME NIGHTTIME SEVERE COLD AND FLU Maximum Strength", "DAYTIME NIGHTTIME SEVERE COLD AND FLU Maximum Strength", "Daytime Nighttime Severe Cold and Flu Relief", "Daytime Nighttime Severe Cold and Flu Relief", "Daytime Nighttime Severe Cold and Flu Relief", "Daytime Nighttime Severe Cold and Flu Relief", "Daytime Nighttime Severe Cold and Flu Relief", "Daytime Nighttime Severe Cold and Flu Relief", "Daytime Nighttime Severe Cold and Flu Relief", "Daytime Nighttime Severe Cold Cough and Flu Relief", "Daytime Nighttime Severe Cough and Cold", "Daytime Nighttime Sinus Relief Maximum Strength", "Daytime Nighttime Sinus Relief Maximum Strength", "Daytime Nighttime Sinus Relief Maximum Strength", "Daytime Nighttime Sinus Relief Maximum Strength", "Daytime Nighttime Sinus Relief Maximum Strength", "Daytime Nighttime Sinus Relief Maximum Strength", "Daytime Nighttime Sinus Relief Maximum Strength", "Daytime Nighttime Sinus Relief Maximum Strength", "Daytime Nighttime Sinus Relief Maximum Strength", "Daytime Nighttime Sinus Relief Maximum Strength", "Daytime Nighttime Sinus Relief Maximum Strength", "Daytime Nighttime Sinus Relief Maximum Strength", "Daytime Nite Time", "Daytime Nite Time", "Daytime Nitetime", "Daytime Nitetime", "Daytime Nitetime", "Daytime Nitetime", "Daytime NiteTime", "Daytime NiteTime", "Daytime Nitetime Cold and Flu", "Daytime Nitetime Cold and Flu", "Daytime Nitetime Cold and Flu", "Daytime Nitetime Cold and Flu", "DayTime NiteTime Cold and Flu", "DayTime NiteTime Cold and Flu", "Daytime Nitetime Cold and Flu", "Daytime Nitetime Cold and Flu", "Daytime Nitetime Cold and Flu", "Daytime Nitetime Cold and Flu", "DayTime Nitetime cold and flu relief", "DayTime Nitetime cold and flu relief", "DayTime NiteTime Cold Flu Relief", "DayTime NiteTime Cold Flu Relief", "DayTime NiteTime Severe", "DayTime NiteTime Severe", "Daytime Non Drows Cold and Flu and Nighttime Cold and", "Daytime Non Drows Cold and Flu and Nighttime Cold and", "Daytime Non Drows Cold and Flu and Nighttime Cold and", "Daytime Non Drows Cold and Flu and Nighttime Cold and", "Daytime Non Drowsy", "Daytime Non Drowsy", "Daytime Non Drowsy", "Daytime Non Drowsy", "Daytime Non Drowsy", "Daytime Non Drowsy", "Daytime Non Drowsy", "Daytime Non-Drowsy Cold and Flu", "Daytime Non-Drowsy Cold and Flu", "Daytime Non-Drowsy COLD/FLU", "Daytime PE", "Daytime PE Nitetime", "Daytime PE Nitetime", "Daytime PE Nitetime", "Daytime PE Nitetime", "Daytime PE Non Drowsy", "Daytime Relief Complete", "Daytime Relief Complete Liquid Gels", "Daytime Relief Severe Cold and Flu", "Daytime Severe", "Daytime Severe", "Daytime Severe", "Daytime Severe Cold And Cough", "Daytime Severe Cold and Cough", "Daytime Severe Cold and Cough", "Daytime Severe Cold and Cough", "Daytime Severe Cold and Cough and Nighttime Severe Cold and Cough", "DAYTIME SEVERE COLD and COUGH NIGHTTIME SEVERE COLD and COUGH", "Daytime Severe Cold and Cough Relief", "Daytime Severe Cold and Flu", "Daytime Severe Cold and Flu", "Daytime Severe Cold and Flu", "Daytime SEVERE COLD and FLU", "Daytime Severe Cold and Flu", "Daytime Severe Cold and Flu", "Daytime Severe Cold and Flu", "Daytime Severe Cold and Flu", "Daytime Severe Cold and Flu", "Daytime Severe Cold and Flu", "Daytime Severe Cold and Flu", "Daytime Severe Cold and Flu Maximum Strength", "Daytime Severe Cold and Flu Nighttime Severe Cold, Cough and Flu", "DayTime Severe Cold and Flu Relief", "Daytime Severe Cold and Flu Relief", "Daytime Severe Cold and Flu Relief", "Daytime Severe Cold and Flu Relief", "DayTime Severe Cold and Flu Relief", "Daytime Severe Cold and Flu Relief", "Daytime Severe Cold and Flu Relief", "DayTime Severe Cold and Flu Relief", "Daytime Severe Cold And Flu Relief Maximum strength", "Daytime Severe Cold and Flu Relief Maximum Strength", "Daytime Severe Cold and Flu Relief Softgels", "Daytime Severe Cold and Flu Relief Softgels", "Daytime Severe Cold Multi-symptom", "Daytime Severe Cold Nighttime Cold and Flu", "Daytime Symptom Relief Extra Strength for Symptoms Of Cold and Cough", "Daytime- Nighttime Cold and Flu", "Daytime- Nighttime Cold and Flu", "Daytime-nighttime Severe Cold and Flu", "Daytime-nighttime Severe Cold and Flu", "Daytime, Nighttime Severe Cold and Flu Relief", "Daytime, Nighttime Severe Cold and Flu Relief", "Daytime/Nighttime Cold and Flu Multi-Symptom Relief", "Daytime/Nighttime Cold and Flu Multi-Symptom Relief", "DayTime/NiteTime Severe Cold and Flu Maximum Strength", "DayTime/NiteTime Severe Cold and Flu Maximum Strength", "Dcp", "DDM Day time and Nite time cold and flu", "DDM Day time and Nite time cold and flu", "De-Chlor DM", "Deconex DM", "Deconex Dmx", "Deconex Dmx", "Deconex DMX", "Deconsal DM", "Defensol Adult Syrup", "Defensol D (Multi Symptom Effervescent Tablets)", "Defensol-ito", "Defensolito Children Syrup", "Delsym", "Delsym", "Delsym", "Delsym", "Delsym", "Delsym", "Delsym", "Delsym", "Delsym", "Delsym", "Delsym", "Delsym", "Delsym (Dextromethorphan)", "Delsym (Dextromethorphan)", "Delsym (Dextromethorphan)", "Delsym and Childrens Delsym", "Delsym and Childrens Delsym", "Delsym Cough", "Delsym Cough Plus Chest Congestion DM", "Delsym Cough Plus Chest Congestion DM and Delsym Cough Plus Cold Night Time", "Delsym Cough Plus Cold Day Time", "Delsym Cough Plus Cold Day Time", "Delsym Cough Plus Cold Day Time and Delsym Cough Plus Cold Night Time", "Delsym Cough Plus Soothing Action", "Delsym Cough Plus Soothing Action", "Delsym Cough Plus Sore Throat", "Delsym Cough Relief Plus Soothing Action", "Delsym Cough Relief Plus Soothing Action", "Delsym DM Suspension 30mg/5ml", "Delsym Night Time Cough and Cold", "Delsym Night Time Multi Symptom", "Delsym Night Time Multi-Symptom", "Delsym Nighttime Cough", "DELTUSS DMX Cough Suppressant Nasal Decongestant Antihistamine GRAPE Flavor", "Demdec Syr", "Desgen DM", "Desgen DM", "DESGEN DM Tabs", "Desgen Pediatric", "Despec", "Despec DM", "Despec DM", "Despec DM Tabs", "Despec EDA Drops", "Despec NR", "Despec-DM Tabs", "Desresfriol-DX Softgels", "Dexbrompheniramine-DM-Phenylephrine 2-15-7.5", "Dextro Phenyl Pyril", "Dextromethorphan HBr", "Dextromethorphan HBr 15 mg", "Dextromethorphan HBr 15 mg", "Dextromethorphan Hbr 15 mg", "Dextromethorphan HBr 15 mg Liquid Gels", "Dextromethorphan HBr and Guaifenesin", "Dextromethorphan HBr and Guaifenesin", "Dextromethorphan HBr, Guaifenesin", "Dextromethorphan Hbr, Guaifenesin", "Dextromethorphan HBr. and Guaifenesin", "Dextromethorphan HBr. and Guaifenesin", "Dextromethorphan Hydrobromide", "Dextromethorphan Hydrobromide", "Dextromethorphan Hydrobromide", "DEXTROMETHORPHAN Hydrobromide", "Dextromethorphan Hydrobromide", "Dextromethorphan Hydrobromide", "DEXTROMETHORPHAN Hydrobromide", "DEXTROMETHORPHAN HYDROBROMIDE and GUAIFENESIN", "DEXTROMETHORPHAN HYDROBROMIDE and GUAIFENESIN", "DEXTROMETHORPHAN HYDROBROMIDE and GUAIFENESIN", "DEXTROMETHORPHAN HYDROBROMIDE and GUAIFENESIN", "DEXTROMETHORPHAN HYDROBROMIDE and GUAIFENESIN", "DEXTROMETHORPHAN HYDROBROMIDE and GUAIFENESIN", "Dextromethorphan Hydrobromide and Promethazine Hydrochloride", "Dextromethorphan Hydrobromide and Promethazine Hydrochloride", "Dextromethorphan Hydrobromide and Promethazine Hydrochloride", "DEXTROMETHORPHAN HYDROBROMIDE, Guaifenesin, and PHENYLEPHRINE HYDROCHLORIDE", "DEXTROMETHORPHAN HYDROBROMIDE, GUAIFENESIN, and PHENYLEPHRINE HYDROCHLORIDE", "Dextromethorphan Hydrobromide, Guaifenesin, Phenylephrine Hydrochloride", "Dextromethorphan Polistirex", "Dextromethorphan Polistirex Extended Release", "Dextromethorphan Polistirex Extended Release", "Dextromethorphan Polistirex Extended Release", "Dextromethorphan Polistirex Extended-Release", "Dextromethorphan Polistirex Extended-Release", "Dextromethorphan Tannate, Phenylephrine Tannate, Dexchlorpheniramine Tannate", "DG Day Time Cold and Flu Formula and Night Time Cold and Flu Formula", "DG Day Time Cold and Flu Formula and Night Time Cold and Flu Formula", "Dg Health Adult Tussin", "DG Health adult tussin multi symptom cold", "DG Health Childrens Cold and Cough", "Dg Health Childrens Mucus Relief", "DG Health Childrens Mucus Relief Cough", "Dg Health Cold and Flu", "DG Health cold and flu relief", "Dg Health Cold and Flu Relief", "Dg Health Cold and Flu Relief", "Dg Health Cold and Flu Relief", "DG Health Cold and Flu Relief", "Dg Health Cold and Flu Relief", "Dg Health Cold and Flu Relief", "DG Health Cold and Flu Relief", "DG Health Cold and Flu Relief", "DG Health Cold and Flu Relief Daytime", "Dg Health Cold and Flu Relief Night Time", "Dg Health Cold and Flu Relief Nite Time", "Dg Health Cold and Flu Severe", "DG Health Cold and Flu Severe", "DG Health Cold and Flu Severe", "DG Health Cold Head Congestion", "Dg Health Cold Head Congestion Severe Day Time", "DG Health Cold Max", "DG Health cold multi symptom nite time", "DG Health cold multi symptom severe", "Dg Health Cold Plus Flu Relief", "Dg Health Cough and Sore Throat Nite Time", "DG Health Cough DM", "DG Health Cough DM", "Dg Health Cough Night Time", "Dg Health Day Time Severe Cold and Flu", "Dg Health Day Time Severe Cold and Flu Relief", "Dg Health Day Time Severe Cold and Flu Relief Night Time Severe Cold and Flu Relief", "Dg Health Day Time Severe Cold and Flu Relief Night Time Severe Cold and Flu Relief", "DG Health DayTime SEVERE Cold and Flu", "DG Health Fast Acting Mucus Relief Severe Cold", "DG Health Fast Acting Mucus Relief Severe Congestion and Cold", "Dg Health Flu and Severe Cold and Cough", "DG health mucus dm", "DG Health Mucus DM", "DG health mucus dm", "Dg Health Mucus Relief", "DG Health Mucus Relief", "Dg Health Multi Symptom Severe Cold", "Dg Health Night Time Cold and Flu Relief", "DG Health night time cold and flu relief", "Dg Health Night Time Severe Cold and Flu Relief", "DG Health NightTime SEVERE Cold and Flu", "DG Health Pain Relief Cold Night Time", "DG Health Triacting Childrens", "DG Health Tussin", "Dg Health Tussin", "DG Health Tussin", "Dg Health Tussin", "DG Health tussin cf adult cough and cold", "Dg Health Tussin DM Adult", "Diabetic Maximum Strength Siltussin DM DAS-Na", "Diabetic Siltussin DM DAS-Na", "Diabetic Siltussin DM DAS-Na", "Diabetic Siltussin DM DAS-Na", "Diabetic Tussin DM", "Diabetic Tussin DM", "Diabetic Tussin DM", "Diabetic Tussin DM Maximum Strength", "Diabetic Tussin DM Maximum Strength", "Diabetic Tussin Nighttime Cold and Flu", "Diabetic Tussin Nighttime Cold and Flu", "Dibromm Cold and Cough Childrens", "DiBromm DM", "Dibromm DM", "Dicel DM", "Dimacol", "Dimaphen DM", "Dimaphen DM", "Dimetane DX", "Dimetapp Children's Cough and Cold Liquid", "Dimetapp Cold and Cough", "Dimetapp Cold and Cough and Dimetapp Nighttime Cold and Congestion", "Dimetapp Cold and Cough and Nighttime Cold and Congestion", "Dimetapp Cough & Cold Liqui-gels - Cap", "Dimetapp Cough & Congestion Liquid", "Dimetapp Cough, Cold & Flu", "Dimetapp DM Cough & Cold", "Dimetapp DM Elixir", "Dimetapp DM Tab", "Dimetapp Extra Strength DM Cough & Cold", "Diphen", "Discount Drugmart Chest Congestion Relief DM", "DM + Expectorant Extra Strength Syrup", "DM + Expectorant Syrup", "DM 7.5mg Croquable (chewable Tablet)", "DM Children's Cough Syrup", "DM Cough and Cold Liquid", "DM Cough and Cold Liquid", "DM Cough and Cold Liquid Cherry Flavour", "DM Cough and Cold Relief", "DM Cough and Cold Syrup", "DM Cough and Congestion Relief Adult non-Drowsy Sugar Free", "DM Cough Syrup", "DM Cough Syrup", "DM Cough Syrup", "DM Cough Syrup", "DM Cough Syrup 15mg/5ml", "DM Cough Syrup Antitussive and Expectorant", "DM Expectorant (extra Strength) Syrup", "DM Expectorant Cough Syrup", "DM MAX Maxium Strength", "DM Max Relief Maximum Strength", "DM Plus Cough Syrup", "DM Plus Decongestant Cough Syrup", "DM Plus Decongestant Plus Expector.ex.st.syr", "DM Plus Decongestant Plus Expectorant Cough Syrup", "DM Plus Expectorant Syrup", "DM Sans Sucre Liq 15mg/5ml", "DM Syrup", "DM Syrup", "DM Syrup (sucrose Free)", "DM-D-expectorant Cough and Cold Syrup", "DM-decongestant Children's Syrup", "DM-decongestant Syrup", "DM-decongestant-expectorant (extra Strength) Syrup", "DM-decongestant-expectorant Syrup", "DM-expectorant Syrup", "Doc in the Box All Day Supply", "Dollar General Chest Congestion Relief DM", "DoloMax Cold Cough", "DoloMax Cold Cough", "Dometuss", "Dometuss-DM", "Dometuss-dmx", "Dometuss-G", "Dometuss-G", "Dometuss-NR", "Donatussin", "Donatussin DM Drops DM", "Double Tussin Intense Cough Reliever DM", "Dr Cocoa Day Night Combo", "Dr Manzanilla DM", "Dr. Cocoa Daytime Cough and Cold", "Dr. Cocoa Daytime Cough and Cold", "Dr. Cocoa for Children Daytime Cough + Cold", "Dr. Cocoa for Children Long-acting Cough", "Dr. Cocoa Non-Drowsy Cough", "Dr. Cocoa Non-Drowsy Cough", "Dristan DM", "Drixoral Cough Liquid Caps - 30mg", "DrKids Children Multi Symptom Cold and Flu", "DrKids Childrens Cough and Chest Congestion DM", "DrKids Childrens Multi Symptom Cold Cough and Congestion DM", "DRx Choice Children daytime Cough and Chest Congestion", "DRx Choice Long Acting Cough", "DRx Choice maximum strength Severe Cough plus sore throat", "Dry Cough", "Dry Cough & Cold Syrup", "Dry Cough Capsules", "Dry Cough Relief Extra Strength", "Dry Cough Relief Extra Strength", "Dry Cough Syrup", "DS Never Cold S", "DS Never Cold S", "Duract Max Strength Cough", "Duract Max Strength Cough", "Duraflu", "Duraflu", "Duravent DM", "Dye Free Cold and Flu", "Dye Free Cold and Flu", "Ed A-hist DM", "Ed-A-hist DM", "Ed-A-hist DM", "End-A-flu Multi-symptom Severe Cold and Cough Non Drowsy Daytime Formula", "EndaCof DM", "EndaCof Drops", "EndaCof PD", "Endacon", "Endal", "Entex PAC", "Entex S", "Entre-Cough", "Entre-S", "Equaline Adult Tussin", "Equaline adult tussin cough and chest congestion", "Equaline Chest Congestion Relief DM DM", "Equaline Childrens Cold", "Equaline Childrens Cold and Cough", "Equaline Childrens Mucus Relief", "Equaline Cold and Flu Relief", "Equaline Cold and Flu Relief", "Equaline Cough DM", "Equaline Cough DM", "Equaline Daytime and Nighttime Cold", "Equaline Daytime and Nighttime Cold", "Equaline Daytime and Nighttime Cold and Flu Relief", "Equaline Daytime and Nighttime Cold and Flu Relief", "Equaline Daytime Cold and Flu Fast Relief Nighttime Cold and Flu Fast Relief", "Equaline Daytime Cold and Flu Fast Relief Nighttime Cold and Flu Fast Relief", "Equaline Daytime Cold and Flu Relief", "Equaline Daytime Cold and Flu Relief", "Equaline Daytime Cold Multi Symptom", "Equaline Daytime Nighttime Cold and Flu Relief", "Equaline Daytime Nighttime Cold and Flu Relief", "Equaline Daytime Severe Cold and Flu Relief", "Equaline Daytime Severe Cold Fast Relief Nighttime Cold and Flu Fast Relief", "Equaline Daytime Severe Cold Fast Relief Nighttime Cold and Flu Fast Relief", "Equaline Mucus DM", "Equaline Mucus DM", "Equaline Mucus DM", "Equaline mucus relief", "Equaline Mucus Relief", "Equaline Mucus Relief", "Equaline Multi Symptom Flu and Severe Cold Daytime", "Equaline night time cough", "Equaline Nighttime", "Equaline Nighttime Cold and Flu Relief", "Equaline Nighttime Cold and Flu Relief", "Equaline Nighttime Cold and Flu Relief", "Equaline Nighttime Cold and Flu Relief", "Equaline nighttime cold and flu relief", "Equaline nighttime cold multi symptom", "Equaline Nighttime Cough Relief", "Equaline Nighttime Severe Cold and Flu", "Equaline Tussin", "Equaline tussin adult", "Equaline tussin cough", "Equaline tussin cough and chest congestion dm max", "Equaline Tussin Cough and Cold", "Equaline Tussin Multi Symptom", "Equate Adult Cough and Chest Congestion DM", "Equate Adult Tussin DM Max", "Equate Adult Tussin DM Max Daytime Nighttime", "Equate Adult Tussin DM Max Daytime Nighttime", "Equate Benz-Dex Cough and Throat Lozenges", "Equate Childrens Cold and Cough", "Equate Childrens Multi Symptom Cold", "Equate Cold and Flu", "Equate Cough DM", "Equate Cough DM", "Equate Cough DM", "Equate Day time cold and flu multi symptom relief", "Equate Daytime", "Equate Daytime Cold and Flu", "Equate Daytime Cold and Flu", "Equate Daytime Cold and Flu", "Equate Daytime Cold and Flu Nighttime Cold and Flu", "Equate Daytime Cold and Flu Nighttime Cold and Flu", "Equate Daytime Liquid Capsules", "Equate Daytime Nighttime Cold and Flu", "Equate Daytime Nighttime Cold and Flu", "Equate DayTime NiteTime", "Equate DayTime NiteTime", "Equate Daytime Nitetime", "Equate Daytime Nitetime", "Equate Daytime Nitetime", "Equate Daytime Nitetime", "Equate DayTime NiteTime Severe", "Equate DayTime NiteTime Severe", "Equate DayTime Severe", "Equate Daytime Severe", "Equate daytime severe vaporice cold and flu nighttime severe vapor ice cold and flu", "Equate daytime severe vaporice cold and flu nighttime severe vapor ice cold and flu", "Equate Daytime Vapor Ice Cold and Flu", "Equate Flu and Severe Cold and Cough", "Equate Health Non Drowsy DAY Cold and Flu Plus and NIGHTTIME Cold and Flu Plus", "Equate Health Non Drowsy DAY Cold and Flu Plus and NIGHTTIME Cold and Flu Plus", "Equate Health Non Drowsy DAY Cold and Flu Plus and NIGHTTIME Cold and Flu Plus", "Equate Health Non Drowsy DAY Cold and Flu Plus and NIGHTTIME Cold and Flu Plus", "Equate Mucus DM", "Equate Mucus Relief DM", "Equate Nightime Cough", "Equate Nighttime Cold and Flu", "Equate Nighttime Cold and Flu", "Equate Nighttime Cold and Flu", "Equate Nighttime Cold and Flu", "Equate Nighttime Liquid Capsules", "Equate Nighttime Vapor Ice Cold and Flu", "Equate Nite Time Cold Flu Relief", "Equate Nite Time Cough", "Equate NiteTime", "Equate Nitetime", "Equate Nitetime", "Equate Nitetime Cold and Flu", "Equate NiteTime DayTime", "Equate NiteTime DayTime", "Equate Nitetime Severe", "Equate Severe Cold Multi Symptom", "Equate Tussin CF", "Equate Tussin DM adult", "Equate Tussin DM Max", "EQUATE Tussin DM Max Daytime Nighttime", "EQUATE Tussin DM Max Daytime Nighttime", "Equate Vapor Ice Cold and Flu", "Equate Vapor Ice Cold and Flu", "Exactuss Total Release", "Exchange Select Mucus DM", "ExeFen DMX", "Expectorant Cough Childrens", "Expectorant DM Cough Extra Strength", "Expectorant DM Cough Extra Strength With Decongestant", "Expectorant DM Cough Syrup", "Expectorant plus Cough Relief", "Expectorant Tab DM", "Extra action Cough", "Extra action Cough", "Extra Strength Cold Medication Day Time Relief", "Extra Strength Cold Medication Daytime Relief", "Extra Strength Cold Medication Daytime Rlf", "Extra Strength Cold Medication Night Time Relief", "Extra Strength Cold Medication Nighttime Relief", "Extra Strength Cold Medication Nighttime Rlf", "Extra Strength Contac Complete Cough, Cold & Flu", "Extra Strength Cough Plus Cold Relief Syrup", "Extra Strength Day and Night Cold Medication", "Extra Strength Day and Night Cold Medication", "Extra Strength Daytime Cold Relief", "Extra Strength Daytime Cold Relief PE", "Extra Strength Daytime Cold Relief-caplet", "Extra Strength Daytime Flu PE", "Extra Strength DM Cough and Cold Liquid", "Extra Strength DM Cough and Cold Syrup", "Extra Strength Flu Relief Daytime", "Extra Strength Mucous Relief Cough", "Extra Strength Neocitran Flu Night", "Extra Strength Neocitran Total Night", "Extra Strength Neocitran Total Syrup", "Extra Strength Nighttime Cold Relief", "Extra Strength Nighttime Cold Relief PE", "Extra Strength Nighttime Cold Relief-caplet", "Extra Strength Nighttime Flu PE", "Extra Strength Tylenol Cold and Flu Daytime", "Extra Strength Tylenol Cold and Flu Nighttime", "Extra Strength Tylenol Cold and Flu Powder", "Extra Strength Tylenol Cold Daytime", "Extra Strength Tylenol Cold Daytime", "Extra Strength Tylenol Cold Nighttime", "Extra Strength Tylenol Cold Nighttime Caplet", "Extra Strength TYLENOL Cold Plus Flu Multi-Action Day", "Extra Strength TYLENOL Cold plus Flu Multi-Action Day/Night", "Extra Strength TYLENOL Cold plus Flu Multi-Action Day/Night", "Extra Strength Tylenol Complete Cold, Cough & Flu", "Extra Strength Tylenol Complete Cold, Cough & Flu Daytime", "Extra Strength Tylenol Complete Cold, Cough & Flu Plus Mucus Relief", "Extra Strength Tylenol Complete Cold, Cough & Flu Plus Mucus Relief Nighttime", "Extra Strength Tylenol Congested Cough Caplets", "Extra Strength Tylenol Cough Caplets", "Extra Strength Tylenol Flu Daytime", "Extra Strength Tylenol Flu Daytime", "Extra Strength Tylenol Flu Nighttime", "Extra Strength TYLENOL Severe Cough Plus Sore Throat Night", "Extra Strength Tylenol Total Cough, Cold & Flu", "Facol Cold and Flu Day", "Facol Cold and Flu Day and Night", "Facol Cold and Flu Night", "Family Care Cold and Flu Multi Symptom", "Family Care Cold and Flu Multi Symptom", "Family Care Cold and Flu Multi Symptom Relief SGC Daytime", "Family Care Cold and Flu Nighttime", "Family Care Cough and Cold", "Family Care Cough Nighttime", "Family Care Multi Symptom Cold", "Family Dollar Daytime and Nighttime Combo Pack Cold and Flu", "Family Dollar Daytime and Nighttime Combo Pack Cold and Flu", "Family Dollar Daytime Cold and Flu Relief", "Family Dollar Multi-Symptom Severe Cold Green Tea and Honey Lemon flavors", "Family Dollar Nighttime Cold and Flu Relief", "Family Dollar Nighttime Cold and Flu Relief Original Flavor", "Family DollarSevere Nighttime Cold and Flu", "Family Wellness Chest Congestion Relief DM DM", "Family Wellness Multi Symptom Severe Cold", "Fast Acting Cold, Flu and Sore Throat Relief", "Fast Acting Cough Relief DM", "Fast Acting Mucus Relief Maximum Strength Severe Cough and Congestion", "Fast Cold and Flu Relief", "Fast Cold and Flu Relief", "Fast Dissolving Daytime - Nighttime Cold and Flu", "Fast Dissolving Daytime - Nighttime Cold and Flu", "Fast Maximum Severe Congestion and Cough", "Fast Mucus Relief", "Fast Mucus Relief", "Fast Mucus Relief", "Fast Mucus Relief", "Fast Mucus Relief Cold Flu and Sore Throat Maximum Strength Multi-Symptom", "Father Johns Cough Medicine Plus", "Father Johns Cough Medicine Plus", "Father Johns Medicine", "Father Johns Medicine", "Febrix Kids PLUS", "First Aid Direct Cough Relief DM", "First Aid Shot Therapy Cold Relief", "Firstcare Dextromethorphan Hydrobromide, Doxylamine Succinate", "Flu and Severe Cold", "Flu and Severe Cold", "Flu and Severe Cold and Cough Daytime", "Flu and Severe Cold and Cough Daytime", "Flu and Severe Cold and Cough daytime", "Flu and Severe Cold and Cough Daytime", "Flu and Severe Cold and Cough Daytime", "Flu and severe cold daytime nighttime", "Flu and Severe Cold Daytime Relief", "Flu BP Maximum Strength", "flu HBP", "Flu HBP", "Flu HBP", "Flu HBP Maximum Strength", "Flu HBP Maximum Strength", "Flu HBP Maximum Strength", "flu HBP Maximum Strength", "Flu HBP Maximum Strength", "Flu HBP Maximum Strength", "Flu HBP Maximum Strength", "Flu HBP Maximum Strength", "Flu HBP Maxium Strength", "Flu Multi Symptom Relief", "Flu Multi Symptom Relief", "Flu Relief", "Flu Relief Childrens", "Flu Relief Therapy", "Flu Relief Therapy Day Time", "Flu Relief Therapy Day Time", "Flu Relief Therapy Day Time", "Flu Relief Therapy Day Time", "Flu Relief Therapy Day Time", "Flu Relief Therapy Day Time", "Flu Relief Therapy Day Time", "Flu Relief Therapy Day Time", "Flu Relief Therapy Day Time", "Flu Relief Therapy Day Time", "Flu Relief Therapy Daytime", "Flu Relief Therapy Daytime", "Flu Relief Therapy Daytime Severe Cold", "FLU-MED DAYTIME SEVERE COLD and COUGH non drowsy formula", "Flu, Cough & Cold Complete", "Flu, Cough & Cold Complete Day and Night", "Flutabs", "FormuCare Cough Syrup DM", "Formule 115 DM", "Foster and Thrive 12 Hour Cough Relief", "Foster and Thrive 12 Hour Cough Relief", "Foster and Thrive Chest Congestion Relief DM DM", "Foster and Thrive Childrens Cold and Cough Relief DM", "Foster and Thrive Daytime Severe Cold and Flu Relief", "Foster and Thrive Nighttime Severe Cold and Flu Relief", "Freds Chest Congestion Relief DM", "Fulton Street Market Cold", "Fulton Street Market cold and flu", "Fulton Street Market Night Time Cold and Flu", "G Tron", "G-bronco-D", "G-P-tuss Dxp", "G-Supress DX", "G-tron Ped", "G-tron Pediatric Drops", "G-tusicof", "G-Tuss-NL", "G-Tuss-NL Ped", "G-Xpect PSE", "G-zyncof", "Gadavyt Cough DM", "Gencontuss", "Geri-Tussin DM", "Geri-tussin DM", "Giltuss", "Giltuss Allergy Plus Cough and Congestion", "Giltuss Childrens Allergy Plus Cough and Congestion", "Giltuss Childrens Cough and Chest Congestion", "Giltuss Childrens Cough and Cold", "Giltuss Childrens MultiSymptom Cold and Flu", "Giltuss Cough and Cold", "Giltuss Cough and Cold", "Giltuss Diabetic Cough and Cold", "Giltuss Diabetic DM", "Giltuss DM", "Giltuss HBP Cough and Chest Congestion", "Giltuss Honey Cough and Chest Congestion", "Giltuss Honey DM Cough", "Giltuss MultiSymptom Cold and Flu", "Giltuss Pediatric", "Giltuss Total Release", "Giltuss TR", "Giltuss TR", "Glenmax PEB DM", "Glenmax PEB DM FORTE", "Glentuss", "good neighbor pharmacy adult tussin DM", "Good Neighbor Pharmacy Childrens Mucus Relief", "Good Neighbor Pharmacy Childrens Pain Relief Plus Cough and Sore Throat", "Good Neighbor Pharmacy Cold", "Good Neighbor Pharmacy Cold", "Good Neighbor Pharmacy Cold", "Good Neighbor Pharmacy Cold", "Good Neighbor Pharmacy Cold", "Good Neighbor Pharmacy Cold", "Good Neighbor Pharmacy Cold and Cough", "Good Neighbor Pharmacy Cold Head Congestion", "Good Neighbor Pharmacy Cold Head Congestion", "Good Neighbor Pharmacy Cold Multi Symptom", "Good Neighbor Pharmacy Cold Multi Symptom", "Good Neighbor Pharmacy Cold Plus Multi Symptom", "Good Neighbor Pharmacy Cold Severe", "Good Neighbor Pharmacy Cough and Sore Throat", "Good Neighbor Pharmacy Cough DM ER", "Good Neighbor Pharmacy Cough DM ER", "Good Neighbor Pharmacy Cough DM ER", "Good Neighbor Pharmacy Cough DM ER Childrens", "Good Neighbor Pharmacy Day Time", "Good Neighbor Pharmacy Day Time", "Good Neighbor Pharmacy Day Time Cold and Flu", "Good Neighbor Pharmacy Day Time Severe", "Good Neighbor Pharmacy Dye Free Severe Cold Multi-Symptom", "Good Neighbor Pharmacy Flu and Severe Cold and Cough", "Good Neighbor Pharmacy Mucus DM", "Good Neighbor Pharmacy Mucus DM", "Good neighbor pharmacy mucus relief", "Good Neighbor Pharmacy Mucus Relief DM", "Good Neighbor Pharmacy Mucus Relief Severe Cold", "Good Neighbor Pharmacy Mucus Relief Severe Cold Cold and Flu Night Time", "Good Neighbor Pharmacy Mucus Relief Severe Congestion and Cold", "Good Neighbor Pharmacy Multi Symptom", "good neighbor pharmacy Night time", "Good Neighbor Pharmacy Night Time", "Good Neighbor Pharmacy Night Time", "Good Neighbor Pharmacy Night Time", "Good Neighbor Pharmacy Night Time", "Good Neighbor Pharmacy Night Time", "Good Neighbor Pharmacy Night Time", "Good Neighbor Pharmacy Night Time", "Good Neighbor Pharmacy Night Time Cold and Flu", "Good Neighbor Pharmacy night time cough", "Good Neighbor Pharmacy Night Time D", "Good Neighbor Pharmacy Night Time D", "Good Neighbor Pharmacy Night Time Severe", "Good Neighbor Pharmacy Severe Cold", "Good Neighbor Pharmacy Severe Day Time", "Good Neighbor pharmacy severe night time", "Good Neighbor Pharmacy Severe Night Time", "Good Neighbor Pharmacy Severe Sinus Congestion", "Good Neighbor Pharmacy Tab Tussin DM DMTDM", "Good Neighbor Pharmacy Tussin", "Good Neighbor Pharmacy Tussin CF", "Good Neighbor Pharmacy Tussin CF Max", "good neighbor pharmacy tussin CF Max", "Good Neighbor Pharmacy Tussin DM", "Good Neighbor Pharmacy Tussin dm", "Good Neighbor Pharmacy Tussin DM Max", "Good Neighbor Pharmacy Tussin DM Max", "Good Neighbor Pharmacy Tussin DM Max", "Good Neighbor Pharmacy tussin dm max adult", "Good Neighbor Pharmacy Tussin DM MAX Nighttime Cough", "Good Sense Adult Tussin DM", "Good Sense Childrens Cold and Cough", "Good Sense Childrens Cold and Cough", "Good Sense Childrens Cold and Cough", "Good Sense Childrens Mucus Relief", "Good Sense Childrens Mucus Relief Cough", "Good Sense Cold", "Good Sense Cold", "Good Sense Cold", "Good Sense Cold and Flu Severe", "Good Sense Cold Head Congestion", "Good Sense Cold Head Congestion Severe", "Good Sense Cold Max", "Good Sense cold multi symptom", "Good Sense cold multi symptom", "Good Sense Cough and Sore Throat Daytime Non Drowsy", "Good Sense Cough and Sore Throat Night Time", "Good Sense Cough DM", "Good Sense Cough DM", "Good Sense Day Time", "Good Sense Day Time Cold and Flu", "Good Sense Day Time Night Time Cold and Flu", "Good Sense Day Time Night Time Cold and Flu", "Good Sense Daytime", "good sense DayTime Night Time", "good sense DayTime Night Time", "Good Sense Daytime non drowsy cold and flu", "Good Sense Flu and Severe Cold and Cough Daytime", "Good Sense Mucus DM", "Good Sense Mucus DM", "Good Sense Mucus DM", "Good Sense Mucus Relief cold flu and sore throat", "Good Sense Mucus Relief Cold Flu and Sore Throat", "Good Sense Mucus Relief Severe Congestion and Cold", "Good Sense Multi Symptom Flu and Severe Cold", "Good Sense Night Time", "Good Sense Night Time", "Good Sense Night Time", "Good Sense Night Time", "Good Sense Night Time Cold and Flu", "Good Sense Night Time Cold and Flu", "Good Sense night time cold and flu", "Good Sense Night Time Cold and Flu", "Good Sense Nighttime", "Good Sense Nighttime Cough", "Good Sense NightTime DayTime Cold and Flu", "Good Sense NightTime DayTime Cold and Flu", "Good Sense Severe Cold", "Good Sense Severe Day Time Cold and Flu", "Good Sense Severe Daytime Cold and Flu", "Good Sense Severe Daytime Cold and Flu", "Good Sense Severe Daytime Cold and Flu Severe Nighttime Cold and Flu", "Good Sense Severe Daytime Cold and Flu Severe Nighttime Cold and Flu", "Good Sense Severe NightTime", "Good Sense Severe NightTime Cold and Flu", "Good Sense Severe Sinus Congestion", "Good Sense Severe Tussin CF Max", "Good Sense Tussin CF", "Good Sense Tussin CF", "Good Sense Tussin CF Cough and Cold", "Good Sense Tussin CF Cough and Cold", "Good Sense Tussin CF Max", "Good Sense Tussin CF Max", "Good Sense Tussin DM", "Good Sense Tussin DM", "Good Sense Tussin DM", "Good Sense Tussin DM", "Good Sense Tussin DM", "Good Sense Tussin DM", "Good Sense Tussin DM", "Good Sense Tussin DM Cough and Chest Congestion", "Good Sense Tussin DM Cough and Chest Congestion", "Good Sense Tussin DM Cough and Chest Congestion", "Good Sense tussin dm max", "Good Sense Tussin DM Max", "Goyescas 7 Syrups Alcohol and Sugar Free Cough and Cold", "Goyescas 7 Syrups Original Cough and Cold", "Goyescas 7 Syrups with Bee Honey Cough and Cold", "Goyescas Broncovac 1 Cough and Cold", "Goyescas Broncovac 2 Cough and Cold", "Goyescas Broncovac 3 Cough and Cold", "Green Guard Cough and Cold Relief", "Green Guard Cough and Cold Relief", "Green Tussin DM", "Green Tussin Pediatric", "Green Tussin SUGAR FREE DM", "Gripmax", "Grippe Extra Fort Jour", "Grippe Extra Fort Nuit", "Guaiasorb DM", "Guaiasorb DM", "Guaifenesin and Dextromethorphan", "Guaifenesin and Dextromethorphan", "Guaifenesin and Dextromethorphan HBr", "Guaifenesin and Dextromethorphan HBr", "Guaifenesin and Dextromethorphan HBr", "Guaifenesin and Dextromethorphan HBr", "Guaifenesin and Dextromethorphan HBr", "Guaifenesin and Dextromethorphan HBr", "Guaifenesin and Dextromethorphan HBr", "Guaifenesin and Dextromethorphan HBr", "Guaifenesin and Dextromethorphan HBr", "Guaifenesin and Dextromethorphan HBr", "Guaifenesin and Dextromethorphan HBr", "Guaifenesin and Dextromethorphan HBr", "Guaifenesin and Dextromethorphan HBr", "Guaifenesin and Dextromethorphan HBr", "Guaifenesin and Dextromethorphan HBr", "Guaifenesin and Dextromethorphan HBr", "Guaifenesin and Dextromethorphan HBr", "Guaifenesin and Dextromethorphan Hbr", "Guaifenesin and Dextromethorphan Hbr", "Guaifenesin and Dextromethorphan HBr", "GUAIFENESIN AND DEXTROMETHORPHAN HBr", "Guaifenesin and Dextromethorphan HBr", "Guaifenesin and Dextromethorphan HBR", "Guaifenesin and Dextromethorphan HBR", "Guaifenesin and Dextromethorphan HBR", "Guaifenesin and Dextromethorphan HBR", "Guaifenesin and Dextromethorphan HBR", "Guaifenesin and Dextromethorphan HBr", "Guaifenesin and Dextromethorphan HBr", "Guaifenesin and Dextromethorphan HBr", "Guaifenesin and Dextromethorphan Hydrobromide", "Guaifenesin and Dextromethorphan Hydrobromide", "Guaifenesin and Dextromethorphan Hydrobromide", "Guaifenesin and Dextromethorphan Hydrobromide", "Guaifenesin and Dextromethorphan Hydrobromide", "Guaifenesin and Dextromethorphan Hydrobromide", "Guaifenesin and Dextromethorphan Hydrobromide", "Guaifenesin and Dextromethorphan Hydrobromide", "Guaifenesin and Dextromethorphan Hydrobromide", "Guaifenesin and Dextromethorphan Hydrobromide", "Guaifenesin and Dextromethorphan Hydrobromide", "Guaifenesin and Dextromethorphan Hydrobromide", "Guaifenesin and Dextromethorphan Hydrobromide", "Guaifenesin and Dextromethorphan Hydrobromide", "Guaifenesin and Dextromethorphan Hydrobromide", "Guaifenesin and Dextromethorphan Hydrobromide", "Guaifenesin and Dextromethorphan Hydrobromide", "Guaifenesin and Dextromethorphan Hydrobromide", "Guaifenesin and Dextromethorphan Hydrobromide HBR", "Guaifenesin and Dextromethorphan Oral Solution", "Guaifenesin and Dextromethorphan Oral Solution", "Guaifenesin DM", "Guaifenesin DM", "Guaifenesin DM", "Guaifenesin DM", "Guaifenesin DM", "Guaifenesin DM", "Guaifenesin DM", "Guaifenesin DM", "Guaifenesin DM", "Guaifenesin DM", "Guaifenesin DM", "Guaifenesin DM", "Guaifenesin DM", "Guaifenesin DM", "Guaifenesin DM", "Guaifenesin Phenylephrine Dextromethorphan", "Guaifenesin Syrup and Dextromethorphan", "Guaifenesin Syrup and Dextromethorphan", "Guaifenesin-DM Nr", "Guaifenesin, Dextromethorphan Hbr", "Guaitussin DM Cough Formula Syr", "Guaitussin DM Syrup", "Guiadrine DX", "Guiatuss DM", "H E B MAX SEVERE CONGESTION and COUGH Maxium Strength", "Handy Solutions Cold Relief", "Handy Solutions Cold Relief", "Hanshinnocol", "Hanshinnocol", "Harmon Face Values Night Time Relief", "Harmon Face Values Night Time Relief", "Harmon Face Values Tussin CF", "Harmon Face Values Tussin DM Adult", "Harris Teeter Cough DM", "Harris Teeter Day Time", "Harris Teeter DayTime", "Harris Teeter DayTime NightTime", "Harris Teeter DayTime NightTime", "Harris Teeter DayTime NightTime", "Harris Teeter DayTime NightTime", "Harris Teeter Mucus Relief DM", "Harris Teeter NightTime", "Harris Teeter NightTime", "Harris Teeter NightTime Cold and Flu", "Harris Teeter Tussin", "Harris Teeter Tussin", "Harris Teeter Tussin", "Harris Teeter Tussin", "Head and Cold", "Head Congestion", "Head Congestion", "Head Congestion and Cold Relief Daytime", "Head Congestion and Flu Severe", "Head Congestion and Flu Severe Relief", "Head Congestion Cold Relief", "Head Congestion Cold Relief", "Head Congestion Daytime and Nighttime Cold", "Head Congestion Daytime and Nighttime Cold", "Head Congestion Flu Severe PE", "Head Congestion Flu Severe PE", "Head Congestion plus Flu Severe", "Head Congestion plus Flu Severe", "Head Congestion plus Flu Severe PE", "head congestion plus flu severe PE", "Head Congestion Plus Flu Severe PE", "Head Congestion plus Flu Severe PE", "Head Congestion plus Flu Severe PE", "Head Congestion plus Flu Severe PE", "Health Mart Adult Tussin", "Health Mart Adult Tussin", "Health Mart Adult Tussin", "Health Mart Adult Tussin", "Health Mart Adult Tussin DM", "Health Mart Childrens Cold and Flu", "Health Mart Childrens Mucus Relief Cough", "Health Mart Cold and Cough childrens", "Health Mart Cough DM", "Health Mart Cough DM", "Health Mart Cough DM", "Health Mart Day Time Cold and Flu Night Time Cold and Flu", "Health Mart Day Time Cold and Flu Night Time Cold and Flu", "Health Mart Daytime", "Health Mart daytime", "Health Mart Daytime", "Health Mart mucus relief DM", "Health Mart Multi-Symptom Cold and Flu Night Time", "Health Mart Night Time Cold and Flu", "Health Mart Night Time Cold and Flu", "Health Mart Severe Cold and Flu", "Health Mart Severe Cold Cough and Flu", "HealthMart Chest Congestion Relief DMDM DM", "HealthMart Mucus Relief FM", "HealthMart Mucus Relief FM", "Healthy Accents Childrens Cold and Cough", "Healthy Accents Childrens Multi Symptom Fever and Cold", "Healthy Accents Cold", "Healthy Accents Cold", "Healthy Accents Cold and Cough", "healthy accents cold and cough DM", "Healthy Accents Cold and Flu", "Healthy Accents Cold Head Congestion", "Healthy Accents Cold Head Congestion", "Healthy Accents cold head congestion daytime non drowsy", "Healthy Accents Cough and Sore Throat Night Time", "Healthy Accents Cough Relief", "Healthy Accents Day Time Night Time", "Healthy Accents Day Time Night Time", "Healthy Accents Daytime", "Healthy Accents Daytime", "Healthy Accents Daytime Cold and Flu", "Healthy Accents Daytime Nighttime Cold and Flu", "Healthy Accents Daytime Nighttime Cold and Flu", "Healthy Accents Daytime Nighttime Cold and Flu", "Healthy Accents Daytime Nighttime Cold and Flu", "Healthy Accents Mucus Relief cold flu and sore throat", "Healthy Accents Mucus Relief DM", "Healthy Accents Mucus Relief Severe Cold", "Healthy Accents Mucus Relief Severe Congestion and Cold", "Healthy Accents Multi Symptom Cold", "Healthy Accents Night Time Cough", "Healthy Accents Nighttime Cold and Flu", "Healthy Accents Nighttime Cold and Flu", "Healthy Accents nighttime cold and flu", "Healthy Accents Nighttime Cold and Flu", "Healthy Accents Nighttime Cold and Flu", "Healthy Accents Nighttime Cold and Flu", "Healthy Accents Severe Cold Daytime", "Healthy Accents Tussin CF", "Healthy Accents Tussin Cough Adult", "Healthy Accents Tussin DM", "Healthy Accents Tussin DM Adult Sugar Free", "Healthy Accents Tussin DM cough and chest congestion", "HEB DayTime Flu And Severe Cold And Cough", "High Blood Pressure Chest Congestion and Cough", "Histenol Cold Tablets", "Histenol II", "Histex-DM", "Histiacil Cough", "Honey Works Kids Honey Cough Syrup", "Honey Works Organic Honey", "HoneyWorks Plus Adult Nighttime Cough Syrup", "Hot Lemon Cough and Cold Relief DM", "Hot Lemon Cough and Colds Relief DM", "Hot Lemon Extra Strength Total Cold Night", "Hot Lemon Night Time Total Extra Strength", "Hot Lemon Relief for Sore Throat and Cough Extra Strength", "Hot Lemon Relief for Symptoms Of Cough and Cold", "Hot Lemon Relief for Symptoms Of Cough, Cold and Flu", "Hot Lemon Relief for Symptoms Of Cough, Cold and Flu Extra Strength", "Hot Lemon Relief for Symptoms Of Cough, Cold and Flu Ultra Strength", "Hot Lemon Total Cold Extra Strength", "Hot Lemon Ultra Strength Total Flu", "Hot Lemon Ultra Strength Total Flu Night", "Hot Liquid Relief for Symptoms Of Cold and Cough", "Ht-tuss DM", "Humana Pharmacy Daytime Cold and Flu Relief", "Humana Pharmacy Tussin Multi Symptom Cold", "Igualtuss", "Immediate-release Mucus Relief DM", "Iophen DM NR", "Jack & Jill Bedtime Honey Cough & Cold", "Jack & Jill Bedtime Multi-symptom Cold & Cough", "Jack & Jill Children's Formula Cough Liquid", "Jack & Jill Complete", "Jack & Jill Cough & Cold", "Jack & Jill Cough and Cold", "Jack & Jill Cough, Cold & Flu Junior Strength Tablets", "Jack & Jill Cough, Sore Throat & Fever", "Jack & Jill Honey Cough & Cold", "Jack & Jill Multi-symptom Cold & Cough", "Jack & Jill Thin Strips Cough", "JEGAMSAN Extract", "Junior Strength Cold DM - Tablet", "Junior Strength Tylenol Cold and Cough", "Junior Strength Tylenol Cold and Cough", "Junior Strength Tylenol Complete Cold, Cough & Fever", "Kidkare cough/cold", "Kids Cough and Chest Congestion", "Kids Cough and Chest Congestion", "Kids Cough Daytime Nighttime Combo", "Kids Cough Daytime Nighttime Combo", "Kids Honey Works", "Kids-EEZE Cough and Cold", "King-Tuss SF", "Kirkland Signature Cold", "Kirkland Signature Mucus DM", "Klernaz", "KMart - Fast Maximum Cold, Flu and Sore Throat Relief", "KMart - Fast Maximum DM MAX", "KMart - Fast Maximum Severe Congestion and Cough", "Koffex DM", "Koffex DM (sucrose Free)", "Koffex DM + Decongestant + Expectorant", "Koffex DM + Decongestant + Expectorant Extra Strength", "Koffex DM + Decongestant Syrup", "Koffex DM + Expectorant", "Koffex DM + Expectorant Extra Strength", "Koffex DM Children", "Koffex DM Pour Enfants Syr 7.5mg/ml", "Koffex DM-D-E - Liq", "Kroger Chest Congestion Relief DM", "Kroger Cough Cold and Flu", "Kroger Daytime and Nighttime Cold and Flu Softgel", "Kroger Daytime and Nighttime Cold and Flu Softgel", "Kroger Daytime Cold and Flu Softgel", "Kroger DayTime Flu plus Severe Cold and Cough", "Kroger Maximum Strength Severe Congestion and Cough", "Kroger Nighttime Cold and Flu Relief", "Kroger Nighttime Cold and Flu Relief", "Kroger Nighttime Cold and Flu Softgel", "L-Oral COLD AND FLU RELIEF Syrup", "L-Oral COLD AND FLU RELIEF-DS Syrup", "L-Oral COUGH RELIEF Syrup", "Leader Adult Tussin DM", "Leader Chest Congestion Relief DM", "Leader Chest Congestion Relief Plus DMDM DM", "Leader Childrens Cold and Cough", "Leader Childrens Cold and Cough", "Leader Childrens Cough DM", "Leader Childrens Mucus and Cough Relief", "Leader Childrens Mucus Relief", "Leader Childrens Mucus Relief Cough", "Leader Childrens Mucus Relief Multi Symptom Cold", "Leader Childrens Multi Symptom Cold", "Leader Cold and Flu", "Leader Cold Head Congestion", "Leader Cold Head Congestion", "Leader Cold Head Congestion", "Leader Cold Relief", "Leader Cough DM", "Leader Cough DM", "Leader Cough DM", "Leader Cough DM", "Leader Cough DM", "Leader Day Time", "Leader Day Time", "Leader Day Time", "Leader Day time Cough and Cold Childrens", "Leader Day Time Multi Symptom Cold Flu Relief", "Leader Daytime Cold and Flu", "Leader Daytime Severe Cold and Flu", "Leader Daytime Severe Cold and Flu Relief", "Leader Flu and Severe Cold and Cough", "Leader Flu and Severe Cold and Cough", "Leader Flu and Severe Cold and Cough", "LEADER iNTENSE COUGH RELIEVER", "Leader Maximum Strength Mucus Relief DM", "Leader Mixed Berry Benz-Dex Lozenges", "Leader Mucus DM", "Leader Mucus DM", "Leader Mucus Relief", "Leader Mucus Relief Cold Flu and Sore Throat", "Leader Mucus Relief Cold Flu and Sore Throat", "Leader Mucus Relief Sever Cold", "Leader Mucus Relief Severe Congestion and Cold", "Leader multi symptom flu and severe cold", "Leader Nighttime Cold and Flu", "Leader Nighttime Cold and Flu", "Leader Nighttime Cold and Flu", "Leader Nighttime Cough", "Leader Nighttime Sever Cold and Flu", "Leader Nighttime Severe Cold and Flu", "Leader Nite Time", "Leader Nite Time", "Leader Nite Time", "Leader Nite Time", "Leader Nite Time", "Leader Nite Time Cold Flu Relief Multi Symptom", "Leader Nite Time Cough", "Leader Nite Time Multi Symptom Cold and Flu Relief", "Leader nite time multi symptom cold flu relief", "Leader Nite Time Severe Cold and Flu", "Leader Severe Cold and Flu", "Leader severe cold and flu", "Leader Severe Sinus Congestion", "Leader TabTussin DM TDM", "Leader Tussin", "Leader Tussin", "Leader Tussin", "Leader Tussin CF", "Leader Tussin CF", "Leader Tussin CF", "Leader Tussin CF Max", "Leader Tussin DM", "Leader Tussin DM", "Leader Tussin DM", "Leader Tussin DM", "Leader Tussin DM", "Leader Tussin DM", "Leader Tussin DM Cough Plus Chest Congestion DM", "Leader tussin dm max adult", "Libera Tos", "Libera Tos", "Libera Tos", "LIDL Daytime Cold and Flu Relief Multi Symptom", "LIDL Nightyime Cold and Flu Relief", "Lil Drug Store Cold Relief", "Lil Drug Store Cold Relief", "Lil Drug Store Nighttime Cold and Flu", "Lil Drug Store Nighttime Cold and Flu", "Lil Drug Store Nighttime Cold and Flu", "Lil Drug Store NyQuil Severe Cold and Flu, Max Strength", "Lil Drug Store Tylenol Cold plus Flu Severe", "Limpia Pecho", "Little Colds Decongestant Plus Cough", "Little Colds Decongestant Plus Cough", "Little Colds Multi Symptom Cold", "Little Colds Multi Symptom Cold plus Fever", "Little Colds Multi-symptom Cold Formula", "LoHist DM", "LoHist PEB DM", "LoHist PSB DM", "Long Acting Cough Softgels", "Long Acting Cough Softgels", "Long Acting Cough Softgels", "Long Acting Cough Softgels", "Long Acting Tussin Cough Gels", "Long Acting Tussin Cough Gels", "Lortuss DM", "Lortuss DM", "M-end DM", "M-end Dmx", "M-Hist DM", "Madame Pearl's Cough Syrup", "Madame Pearl's Cough Syrup", "Major Night Time Multi Symptom cold and flu relief", "Marcs Chest Congestion Relief DM", "Maux De Gorge Et De LA Toux Extra-fort", "MAX Cold, Flu, and Sore Throat", "MAX Tussin Cough and Chest Congestion DM", "MAX Tussin Cough and Chest Congestion DM Sugar Free", "Maxi-Tuss DM", "Maxi-Tuss G", "Maxi-Tuss GMX", "Maxi-Tuss Jr", "Maxichlor PEH DM", "Maximum Strenght Day Cold and Flu Formula", "Maximum Strength Adult Cough plus Chest Congestion DM", "Maximum Strength Chest Congestion and Cough", "Maximum Strength Cold and Flu", "Maximum Strength Cold and Flu", "Maximum Strength Cold and Flu", "Maximum Strength Cold and Flu", "Maximum Strength Cold Flu and Sore Throat", "Maximum Strength Cold Flu and Sore Throat", "Maximum Strength Cold, Flu and Sore Throat", "Maximum Strength Cold, Flu and Sore Throat", "Maximum Strength Congestion and Headache", "Maximum Strength Congestion and Headache", "Maximum Strength Congestion and Headache", "Maximum Strength Cough and Congestion Extended Release", "Maximum Strength Cough Plus Chest Congestion DM", "Maximum Strength Cough Plus Chest Congestion DM", "Maximum Strength Day-night Cold and Flu Formula", "Maximum Strength Day-night Cold and Flu Formula", "Maximum Strength Daytime - Nighttime Cold and Flu Cold and Flu", "Maximum Strength Daytime - Nighttime Cold and Flu Cold and Flu", "Maximum Strength Daytime Cold/Flu Relief", "Maximum Strength Daytime Nighttime Cold and Flu", "Maximum Strength Daytime Nighttime Cold and Flu", "Maximum Strength Daytime Nighttime Sinus Relief", "Maximum Strength Daytime Nighttime Sinus Relief", "Maximum Strength Daytime Non Drowsy Severe Cold and Flu", "Maximum Strength DM MAX", "Maximum Strength Flu", "Maximum Strength Flu HBP", "Maximum Strength Flu HBP", "Maximum Strength Mucinex Fast-Max Cold and Flu", "Maximum Strength Mucinex Fast-Max Cold and Flu", "Maximum Strength Mucinex Fast-Max Cold and Flu", "Maximum Strength Mucinex Fast-Max Cold and Flu", "Maximum Strength Mucinex Fast-Max Cold and Flu and Mucinex NightShift Severe Cold and Flu", "Maximum Strength Mucinex Fast-Max Cold and Flu and Mucinex NightShift Severe Cold and Flu", "Maximum Strength Mucinex Fast-Max Cold and Flu and Mucinex NightShift Severe Cold and Flu", "Maximum Strength Mucinex Fast-Max Cold and Flu and Mucinex NightShift Severe Cold and Flu", "Maximum Strength Mucinex Fast-Max Day Cold and Flu and Night Cold and Flu", "Maximum Strength Mucinex Fast-Max Day Cold and Flu and Night Cold and Flu", "Maximum Strength Mucinex Fast-Max Day Time Cold and Flu and Maximum Strength Mucinex Fast-Max Night Time Cold and Flu", "Maximum Strength Mucinex Fast-Max Day Time Cold and Flu and Night Time Cold and Flu", "Maximum Strength Mucinex Sinus-Max Pressure, Pain and Cough", "Maximum Strength Mucinex Sinus-Max Severe Congestion and Pain and Mucinex Nightshift Sinus", "Maximum Strength Mucus DM Extended Release", "Maximum Strength Mucus Relief Cold Flu and Sore Throat", "Maximum Strength Mucus Relief Cold,Flu and Sore Throat", "Maximum Strength Mucus Relief Cold,Flu and Sore Throat", "Maximum Strength Mucus Relief DM", "Maximum Strength Mucus Relief DM", "Maximum Strength Mucus Relief DM", "Maximum Strength Mucus Relief DM", "Maximum Strength Mucus Relief DM", "Maximum Strength Mucus Relief DM", "Maximum Strength Mucus Relief Severe Congestion and Cough", "Maximum Strength Mucus Relief Severe Congestion and Cough", "Maximum Strength Mucus Relief Severe Congestion and Cough", "Maximum Strength Mucus Relief Severe Congestion and Cough", "Maximum Strength Mucus Relief Severe Congestion and Cough Cooling Menthol", "Maximum Strength Mucus-DM", "Maximum Strength Night Time Cold and Flu Relief", "Maximum Strength Nighttime Cold and Flu", "Maximum Strength Nighttime Cold/Flu Relief", "Maximum Strength Nighttime Cold/Flu Relief", "Maximum Strength Nighttime Sever Cold and Flu", "Maximum Strength Non Drowsy Day and Night Cold and Flu", "Maximum Strength Non Drowsy Day and Night Cold and Flu", "Maximum Strength Non Drowsy Daytime Severe Cold and Flu", "Maximum Strength Non Drowsy Daytime Severe Cold and Flu", "Maximum Strength Severe Congestion and Cough", "Maximum Strength Severe Congestion Relief", "Maximum Strength Severe Congestion Relief", "Maximum Strength Severe Sinus Pressure, Pain and Cough Relief", "Maximum strength Tussnex FM DM Max", "Maximum Strength-Cough and Chest Congestion DM", "Maximum Strenth Night Cold and Flu Formula", "Maxiphen DM", "Maxium Strength DM Max", "MAXIUM STRENGTH SEVERE CONGESTION and COUGH MAX", "McKesson Nite Time", "Medi-First Cold Relief", "Medi-First Cold Relief", "Medi-First Cough Cold", "Medi-First Plus Cold Relief", "Medi-First Plus Cold Relief", "Medi-First Plus Cough Cold", "Medicament Pour Le Rhume, Jour", "Medicament Pour Le Rhume, Nuit", "Mediqe Medi-Mucus", "Medique at Home Cold Relief", "Medique at Home Decorel Forte", "Medique Cold Cough Product", "Medique Decorel Forte", "Medique Decorel Forte Plus", "Medique Decorel Forte Plus", "Medique Guaicon DMS", "Medique Medi-Mucus", "Meds on the Go", "Meijer Adult Severe Multi-Symptom Cough Cold Flu", "Meijer Children Cough and Chest Congestion DM Grape Flavor", "meijer Daytime and Nighttime Cold and Flu SOFTGEL", "meijer Daytime and Nighttime Cold and Flu SOFTGEL", "Meijer Daytime Severe Cold and Cough Berry infused with Menthol and Green Tea flavors", "meijer Maximum Strength Nighttime Cough DM", "Meijer Maximum Strength Severe Congestion and Cough", "Meijer Mucus Relief DM Maximum Strength", "Meijer Multi-Symptom Severe Cold Green Tea and Honey Lemon flavors", "Meijer Nighttime Cold and Flu", "Meijer Nitetime Cold and Flu Relief", "Members Mark mucus relief DM", "Members Mark Mucus Relief DM", "Mesehist DM", "Methorphan", "Metrate", "Miclara DM", "Mielim y mas", "Mintuss DR", "Mixed Berry Sore Throat and Cough lozenge", "Mixed Berry Sore Throat and Cough Lozenge", "Mixed Berry Sore Throat and Cough Lozenge", "Mixed Berry Sore Throat and Cough Lozenge", "Mixed Berry Sore Throat and Cough Lozenge", "Mixed Berry sore throat and cough lozenge", "Mixed Berry Sore Throat and Cough Lozenge", "Mixed Berry Sore Throat and Cough Lozenges", "Mixed Berry Sore Throat Lozenge", "Mixed Berry Sore Throat Lozenges", "Mixed Berry Throat and Cough Lozenges", "MMM - Cough Formula Guaifenesin DM", "Moore Medical MooreBrand Severe Cold Relief", "Moore Medical MooreBrand Severe Cold Relief", "Mucinar Kids PLUS", "Mucinar PLUS", "Mucinar PLUS", "Mucinex Childrens Cold and Flu", "Mucinex Childrens Cough", "Mucinex Childrens Cough and Chest Congestion Mini-Melts Orange Creme", "Mucinex Childrens Cough and Congestion", "Mucinex Childrens Cough and Congestion", "Mucinex Childrens Cough Mini-Melts Orange Creme", "Mucinex Childrens Day Time Multi-Symptom Cold and Mucinex Childrens Night Time Multi-Symptom Cold Triple Pack", "Mucinex Childrens Day Time Multi-Symptom Cold and Night Time Multi-Symptom Cold", "Mucinex Childrens FreeFrom Cough and Mucus", "Mucinex Childrens FreeFrom Multi-Symptom Cold and Flu Nighttime", "Mucinex Childrens FreeFrom Multi-Symptom Cold and Stuffy Nose", "Mucinex Childrens FreeFrom Multi-Symptom Cold, Flu and Sore Throat", "Mucinex Childrens FreeFrom Multi-Symptom Cold, Flu and Sore Throat and Mucinex Childrens FreeFrom Multi-Symptom Cold and Flu Nighttime", "Mucinex Childrens FreeFrom Multi-Symptom Cold, Flu and Sore Throat and Mucinex Childrens FreeFrom Multi-Symptom Cold and Flu Nighttime", "Mucinex Childrens FreeFrom Multi-Symptom Cold, Flu and Sore Throat and Mucinex Childrens FreeFrom Multi-Symptom Cold and Flu Nighttime", "Mucinex Childrens FreeFrom Multi-Symptom Cold, Flu and Sore Throat and Mucinex Childrens FreeFrom Multi-Symptom Cold and Flu Nighttime", "Mucinex Childrens Multi-Symptom Cold", "Mucinex Childrens Multi-Symptom Cold and Sore Throat", "Mucinex Childrens Multi-Symptom Cough, Cold and Fever", "Mucinex Cough Chest Congestion", "Mucinex DM", "Mucinex DM", "Mucinex DM", "Mucinex DM", "Mucinex DM", "Mucinex DM", "Mucinex DM", "Mucinex DM", "Mucinex DM", "Mucinex DM", "Mucinex DM", "Mucinex DM", "Mucinex DM", "Mucinex DM", "Mucinex DM", "Mucinex DM", "Mucinex DM Maximum Strength", "Mucinex DM Maximum Strength", "Mucinex DM Maximum Strength", "Mucinex DM, CVP HEALTH", "Mucinex DM, TRAVEL BASIX", "Mucinex Fast Max Day Time Severe Congestion and Cough and Night Time Cold and Flu", "MUCINEX FAST MAX Liquid Cold and Flu Kickstart and MUCINEX Nightshift Kickstart", "MUCINEX FAST MAX Liquid Cold and Flu Kickstart and MUCINEX Nightshift Kickstart", "Mucinex Fast-Max Cold and Flu", "Mucinex Fast-Max Cold and Flu and Mucinex NightShift Cold and Flu", "Mucinex Fast-Max Cold and Flu and Mucinex NightShift Cold and Flu", "Mucinex Fast-Max Cold and Flu Arctic Burst and Nightshift Severe Cold and Flu Arctic Burst", "Mucinex Fast-Max Cold and Flu Arctic Burst and Nightshift Severe Cold and Flu Arctic Burst", "Mucinex Fast-Max Cold and Flu Arctic Burst Maximum Strength", "Mucinex Fast-Max Cold and Flu Maximum Strength", "Mucinex Fast-Max Cold, Flu and Sore Throat", "Mucinex Fast-Max Cold, Flu and Sore Throat", "Mucinex Fast-Max Cold, Flu and Sore Throat", "Mucinex Fast-Max Cold, Flu and Sore Throat", "Mucinex Fast-Max Cold, Flu and Sore Throat", "Mucinex Fast-Max Cold, Flu and Sore Throat", "Mucinex Fast-Max Cold, Flu and Sore Throat and Mucinex NightShift Cold and Flu", "Mucinex Fast-Max Cold, Flu and Sore Throat and Mucinex NightShift Cold and Flu", "Mucinex Fast-Max Cold, Flu and Sore Throat Clear and Cool", "Mucinex Fast-Max Cold, Flu and Sore Throat Maximum Strength", "Mucinex Fast-Max Congestion and Headache", "Mucinex Fast-Max Congestion and Headache Maximum Strength", "Mucinex Fast-Max Day Cold and Flu and Mucinex Nightshift Night Severe Cold and Flu Maximum Strength", "Mucinex Fast-Max Day Cold and Flu and Mucinex Nightshift Night Severe Cold and Flu Maximum Strength", "Mucinex Fast-Max Day Cold and Flu and Night Cold and Flu Maximum Strength", "Mucinex Fast-Max Day Cold and Flu and Night Cold and Flu Maximum Strength", "Mucinex Fast-Max Day Cold and Flu and Night Cold and Flu Maximum Strength", "Mucinex Fast-Max Day Cold and Flu and Night Cold and Flu Maximum Strength", "Mucinex Fast-Max Day Severe Cold and Night Cold and Flu", "Mucinex Fast-Max Day Severe Cold and Night Cold and Flu", "Mucinex Fast-Max Day Severe Congestion and Cough and Mucinex Nightshift Night Cold and Flu Maximum Strength", "Mucinex Fast-Max Day Severe Congestion and Cough and Mucinex Nightshift Night Cold and Flu Maximum Strength", "Mucinex Fast-Max Day Severe Congestion and Cough and Night Cold and Flu", "Mucinex Fast-Max Day Severe Congestion and Cough and Night Cold and Flu", "Mucinex Fast-Max Day Time Cold and Flu and Night Time Cold and Flu", "Mucinex Fast-Max Day Time Severe Cold and Mucinex Fast-Max Night Time Cold and Flu Maximum Strength", "Mucinex Fast-Max Day Time Severe Cold and Mucinex Fast-Max Night Time Cold and Flu Maximum Strength", "Mucinex Fast-Max Day Time Severe Cold and Mucinex Fast-Max Night Time Cold and Flu Maximum Strength", "Mucinex Fast-Max Day Time Severe Cold and Mucinex Fast-Max Night Time Cold and Flu Maximum Strength", "Mucinex Fast-Max Day Time Severe Congestion and Cough - Mucinex Fast-Max Night Time Cold and Flu Maximum Strength", "Mucinex Fast-Max Day Time Severe Congestion and Cough and Mucinex Fast-Max Night Time Cold and Flu Maximum Strength", "Mucinex Fast-Max Day Time Severe Congestion and Cough and Mucinex Fast-Max Night Time Cold and Flu Maximum Strength", "Mucinex Fast-Max DM Max", "Mucinex Fast-Max DM Max", "Mucinex Fast-Max DM Max and Mucinex Nightshift Cold and Flu", "Mucinex Fast-Max DM Max and Mucinex Nightshift Cold and Flu", "Mucinex Fast-Max DM Max Honey and Berry Flavor", "Mucinex Fast-Max Kickstart Severe Cold and Flu", "Mucinex Fast-Max Night Time Cold and Flu", "Mucinex Fast-Max Severe Cold", "Mucinex Fast-Max Severe Cold", "Mucinex Fast-Max Severe Cold", "Mucinex Fast-Max SEVERE COLD", "Mucinex Fast-Max Severe Cold", "Mucinex Fast-Max Severe Cold and Sinus", "Mucinex Fast-Max Severe Congestion and Cold", "Mucinex Fast-Max Severe Congestion and Cough", "Mucinex Fast-Max Severe Congestion and Cough", "Mucinex Fast-Max Severe Congestion and Cough", "Mucinex Fast-Max Severe Congestion and Cough", "Mucinex Fast-Max Severe Congestion and Cough", "Mucinex Fast-Max Severe Congestion and Cough and Mucinex Nightshift Cold and Flu", "Mucinex Fast-Max Severe Congestion and Cough and Mucinex Nightshift Cold and Flu", "Mucinex Fast-Max Severe Congestion and Cough Arctic Burst Maximum Strength", "Mucinex Fast-Max Severe Congestion and Cough Clear and Cool", "Mucinex Fast-Max Severe Congestion and Cough Clear and Cool and Maximum Strength Mucinex Nightshift Cold and Flu Clear and Cool", "Mucinex Fast-Max Severe Congestion and Cough Clear and Cool and Maximum Strength Mucinex Nightshift Cold and Flu Clear and Cool", "Mucinex Fast-Max Severe Congestion and Cough Clear and Cool and Mucinex Fast-Max Night Time Cold and Flu Clear and Cool", "Mucinex Fast-Max Severe Congestion and Cough Liquid Pouches", "Mucinex FreeFrom Cold and Flu Daytime", "Mucinex FreeFrom Cold and Flu Daytime and Mucinex FreeFrom Cold and Flu Nighttime", "Mucinex FreeFrom Cold and Flu Daytime and Mucinex FreeFrom Cold and Flu Nighttime", "Mucinex FreeFrom Cold and Flu Nighttime", "Mucinex FreeFrom Severe Congestion and Cough", "Mucinex Instasoothe Sore Throat Plus Cough Relief", "Mucinex Junior Cold and Flu", "Mucinex Multi-action Congestion & Cold Caplets", "Mucinex Multi-action Congestion, Cold & Cough", "Mucinex Multi-action Congestion, Cold & Cough Solution", "Mucinex Multi-action Congestion, Stuffy Nose & Cough Liquid", "Mucinex Multi-action Wet & Dry Cough Liquid", "Mucinex Night Time Severe Cold and Flu", "Mucinex Nightshift Cold and Flu", "Mucinex Nightshift Cold and Flu Clear and Cool", "Mucinex Nightshift Cold and Flu Maximum Strength", "Mucinex Nightshift Severe Cold and Flu", "Mucinex Nightshift Severe Cold and Flu Arctic Burst", "Mucinex Nightshift Severe Cold and Flu Maximum Strength", "Mucinex Nightshift Sinus", "Mucinex Nightshift Sinus Clear and Cool", "Mucinex Nightshift Sinus Maximum Strength", "Mucinex Sinus - Max Day / Night", "Mucinex Sinus - Max Day / Night", "Mucinex Sinus-Max Day and Night Maximum Strength", "Mucinex Sinus-Max Day and Night Maximum Strength", "Mucinex Sinus-Max Day Pressure, Pain and Cough and Mucinex Nightshift Night Sinus Maximum Strength", "Mucinex Sinus-Max Day Pressure, Pain and Cough and Mucinex Nightshift Night Sinus Maximum Strength", "Mucinex Sinus-Max Pressure, Pain and Cough", "Mucinex Sinus-Max Pressure, Pain and Cough", "Mucinex Sinus-Max Pressure, Pain and Cough and Mucinex Sinus-Max Severe Congestion Relief Clear and Cool", "Mucinex Sinus-Max Pressure, Pain and Cough Maximum Strength", "Mucinex Sinus-Max Severe Congestion and Pain", "Mucinex Sinus-Max Severe Congestion and Pain Maximum Strength", "Mucinex Sinus-Max Severe Congestion Relief", "Mucinex-Sinus Max Severe Congestion and Pain Clear and Cool and Mucinex Nightshift Sinus Clear and Cool", "Mucosa DM", "Mucosa DM", "Mucosa DM", "Mucus & Phlegm Relief With Cough Control Extra Strength", "Mucus & Phlegm Relief With Cough Control Extra Strength", "Mucus and Cough Relief", "Mucus Congestion and Cough Relief Childrens", "Mucus DM", "Mucus DM", "Mucus DM", "Mucus DM", "Mucus DM", "Mucus DM Extended Release", "Mucus DM Extended Release", "Mucus DM Extended Release", "Mucus DM Extended Release", "Mucus DM Extended Release", "Mucus DM Extended-Release", "Mucus DM Fast Max Day Cold and Flu and Night Cold and Flu", "Mucus DM Fast Max Day Cold and Flu and Night Cold and Flu", "Mucus DM Max", "Mucus DM Max", "Mucus Fast Max Day Cold and Flu and Night Cold and Flu", "Mucus Fast Max Day Cold and Flu and Night Cold and Flu", "Mucus Multi Symptom Cold Relief Childrens", "Mucus Relief", "Mucus Relief", "Mucus Relief - DM Maximum Strength", "Mucus Relief All In One Cold and Flu", "Mucus Relief All In One Daytime Nighttime Cold Flu Maximum Strength", "Mucus Relief All in One Maximum Strength", "Mucus Relief All in One Maximum Strength", "Mucus Relief Cold and Flu", "Mucus Relief Cold and Flu", "Mucus Relief Cold and Flu All In One", "Mucus Relief Cold and Flu All in One", "Mucus Relief Cold and Flu all in one", "Mucus Relief Cold and Flu All in One", "Mucus Relief Cold and Flu All in One", "Mucus Relief Cold and Flu All in One", "Mucus Relief Cold and Flu Daytime Nighttime", "Mucus Relief cold and flu Daytime/Nighttime", "Mucus Relief Cold Flu and Sore Throat", "Mucus Relief cold flu and sore throat", "Mucus Relief Cold Flu and Sore Throat", "Mucus Relief Cold Flu and Sore Throat", "Mucus Relief Cold Flu and Sore Throat", "Mucus Relief Cold Flu and Sore Throat", "Mucus Relief Cold Flu and Sore Throat", "Mucus Relief Cold Flu and Sore Throat", "Mucus Relief Cold Flu and Sore Throat", "Mucus Relief Cold Flu and Sore Throat", "Mucus Relief Cold Flu and Sore Throat", "Mucus Relief Cold Flu and Sore Throat", "Mucus Relief Cold Flu and Sore Throat Max Maximum Strength", "Mucus Relief Cold Flu and Sore Throat Maximum Strength", "Mucus Relief Cold Flu and Sore Throat Maximum Strength", "Mucus Relief Cold Flu and Sore Throat Maximum Strength", "Mucus Relief Cold Flu and Sore Throat Maximum Strength", "Mucus Relief Cold Flu and Sore Throat Maximum Strength", "Mucus Relief Cold Flu and Sore Throat Maximum Strength", "Mucus Relief Cold Flu and Sore Throat Maximum Strength", "Mucus Relief Cold Flu and Sore Throat Maximum Strength", "Mucus Relief Cold Flu and Sore Throat Maximum Strength", "Mucus Relief Cold Flu and Sore Throat Maximum Strength", "Mucus Relief Cold Flu and Sore Throat Maximum Strength", "Mucus Relief Cold Flu and Sore Throat Maximum Strength", "Mucus Relief Cold Flu Sore Throat", "Mucus Relief Cold Flu Sore Throat Maximum Strength", "Mucus Relief Cold Flu Sore Throat Maximum Strength", "Mucus Relief Cold Flu Sore Throat Maximum Strength", "Mucus Relief Cold Flu Sore Throat Maximum Strength", "Mucus Relief Cold Flu Sore Throat Maximum Strength", "Mucus Relief Cold Flu Sore Throat Maximum Strength", "Mucus Relief Cold Flu Sore Throat Maximum Strength", "Mucus Relief Cold, Flu and Sore Throat", "Mucus Relief Cold, Flu and Sore Throat", "Mucus Relief Cold, Flu and Sore Throat", "Mucus Relief Cold, Flu and Sore Throat", "Mucus Relief Cold, Flu and Sore Throat", "Mucus Relief Cold, Flu and Sore Throat", "Mucus Relief Cold, Flu and Sore Throat", "Mucus Relief Cold, Flu and Sore Throat", "Mucus Relief Cold, Flu and Sore Throat Maximum Strength", "Mucus Relief Cold, Flu and Sore Throat Maximum Strength", "Mucus Relief Cold, Flu and Sore Throat Maximum Strength", "Mucus Relief Cold, Flu and Sore Throat Maximum Strength", "Mucus Relief Cold, Flu and Sore Throat Maximum Strength", "Mucus Relief Cold, Flu, and Sore Throat Maximum Strength", "Mucus Relief Cold, Flu, Sore Throat Maximum Strength", "Mucus Relief Cold, Flu, Sore Throat Maximum Strength", "Mucus Relief Complete", "Mucus Relief Congestion and Cough Maximum Strength", "Mucus Relief Congestion and Cough Maximum Strength", "Mucus Relief Congestion Cough Maximum Strength Severe Congestion and Cough", "Mucus Relief Cough", "Mucus Relief Cough", "Mucus Relief Cough and Congestion Childrens", "Mucus Relief Cough and Congestion DM", "Mucus Relief Cough and Congestion DM", "Mucus Relief Cough and Congestion DM", "Mucus Relief Cough and Congestion DM", "Mucus Relief Cough Childrens", "Mucus Relief Cough Childrens", "Mucus Relief Cough Childrens", "Mucus Relief Cough Childrens", "Mucus Relief Cough Cold Sore Throat", "Mucus Relief Day Time and Night Time", "Mucus Relief Daytime Severe Cold Nighttime Cold and Flu Maximum Strength", "Mucus Relief Daytime Severe Cold Nighttime Cold and Flu Maximum Strength", "Mucus Relief Daytime Severe Cold Nighttime Cold and Flu Maximum Strength", "Mucus Relief Daytime Severe Cold Nighttime Cold and Flu Maximum Strength", "Mucus Relief Daytime/Nighttime", "Mucus Relief Daytime/Nighttime/Maximum Strength", "Mucus Relief DM", "Mucus Relief DM", "Mucus Relief DM", "Mucus Relief DM", "Mucus Relief DM", "Mucus Relief DM", "Mucus Relief DM", "Mucus Relief DM", "Mucus Relief DM", "Mucus Relief DM", "Mucus Relief DM", "Mucus Relief DM", "Mucus Relief DM", "Mucus Relief DM", "Mucus Relief DM", "Mucus Relief DM", "Mucus Relief DM", "Mucus Relief DM", "Mucus Relief DM", "Mucus Relief DM", "Mucus Relief DM", "Mucus Relief DM", "Mucus Relief DM", "Mucus Relief DM", "Mucus Relief DM", "Mucus Relief DM", "Mucus Relief DM", "Mucus Relief DM", "Mucus Relief DM", "Mucus Relief DM", "Mucus Relief DM", "Mucus Relief DM", "Mucus Relief DM", "Mucus Relief DM", "Mucus Relief DM", "Mucus Relief DM", "Mucus Relief DM", "mucus relief DM", "Mucus Relief DM", "Mucus Relief DM", "Mucus Relief DM", "Mucus Relief DM", "Mucus Relief DM", "Mucus Relief DM", "Mucus Relief DM", "Mucus Relief DM", "Mucus Relief DM", "Mucus Relief DM", "mucus relief DM", "Mucus Relief DM", "Mucus Relief DM", "Mucus Relief DM", "Mucus Relief DM", "Mucus Relief DM", "Mucus Relief DM", "Mucus Relief DM", "Mucus Relief DM", "Mucus Relief DM", "Mucus Relief DM", "Mucus Relief DM", "Mucus Relief DM", "Mucus Relief DM", "Mucus Relief DM", "Mucus Relief DM", "Mucus Relief DM", "Mucus Relief DM", "Mucus Relief DM", "Mucus Relief DM", "Mucus Relief DM", "Mucus Relief DM", "Mucus Relief DM", "Mucus Relief DM", "mucus relief DM", "Mucus Relief DM", "Mucus Relief DM", "Mucus Relief DM", "Mucus Relief DM", "Mucus Relief DM", "Mucus Relief DM", "Mucus Relief DM and Overnight Cold and Flu", "Mucus Relief DM and Overnight Cold and Flu", "Mucus Relief DM Cough", "Mucus Relief DM Cough", "Mucus Relief DM Cough Maximum Strength", "Mucus Relief DM Expectorant and Cough Suppressant", "Mucus Relief DM Expectorant and Cough Suppressant", "Mucus Relief DM Expectorant and Cough Suppressant Maximum Strength", "Mucus Relief DM Extended Release", "Mucus Relief DM Extended Release Caplets", "Mucus Relief DM Extended Release Caplets", "Mucus Relief DM Extended Release Caplets", "Mucus Relief DM Extended Release Caplets", "Mucus Relief DM Extended Release Caplets", "Mucus Relief DM Extended Release Caplets", "Mucus Relief DM Extended Release Caplets", "Mucus Relief DM Extended Release Caplets", "Mucus Relief DM Extended Release Caplets", "Mucus Relief DM Extended Release Caplets", "Mucus Relief DM Extended Release Caplets Maximum Strength", "Mucus Relief DM Extended Release Caplets Maximum Strength", "Mucus Relief DM Honey and Berry Flavor", "Mucus Relief DM Honey and Berry Flavor", "Mucus Relief DM Immediate Release", "Mucus Relief DM Immediate Release", "Mucus Relief DM Immediate Release", "Mucus Relief DM MAX", "Mucus Relief DM Max", "mucus relief DM MAX", "Mucus Relief DM Max Maximum Strength", "Mucus Relief DM Max Maximum Strength", "Mucus Relief DM MAX Maximum Strength", "Mucus Relief DM Max Maximum Strength", "Mucus Relief DM Max Maximum Strength", "Mucus Relief DM MAX Maximum Strength", "Mucus Relief DM Max Maximum Strength", "Mucus Relief DM Max Maximum Strength", "Mucus Relief DM Max Maximum Strength", "Mucus Relief DM Max Maximum Strength", "Mucus Relief DM Max Maximum Strength Fast Acting", "Mucus Relief DM Maximum Strength", "Mucus Relief DM Maximum Strength", "Mucus Relief DM Maximum Strength", "Mucus Relief DM Maximum Strength", "Mucus Relief DM Maximum Strength", "Mucus Relief DM Maximum Strength", "Mucus Relief DM Maximum Strength", "Mucus Relief DM Maximum Strength", "Mucus Relief DM Maximum Strength", "Mucus Relief DM Maximum Strength", "Mucus Relief DM Maximum Strength", "Mucus Relief DM MAXIMUM STRENGTH", "Mucus Relief DM MAXIMUM STRENGTH", "Mucus Relief DM Maximum Strength", "Mucus Relief DM Maximum Strength", "Mucus Relief DM Maximum Strength", "Mucus Relief DM Maximum Strength", "Mucus Relief DM Maximum Strength", "Mucus Relief DM Maximum Strength", "Mucus Relief DMImmediate Release Immediate Release", "Mucus Relief ER DM Extended Release", "Mucus Relief Maximum Strength", "Mucus Relief Maximum Strength", "Mucus Relief Maximum Strength", "Mucus Relief Maximum Strength", "Mucus Relief Maximum Strength DM Max", "Mucus Relief Maximum Strength Multi Symptom Relief", "Mucus Relief Maximum Strength Severe Congestion and Cough", "Mucus Relief Maximum StrengthCold Flu and Sore Throat", "Mucus Relief Maximum StrengthCold Flu and Sore Throat", "Mucus Relief Maximum StrengthCold Flu and Sore Throat", "Mucus Relief Plus", "Mucus Relief Plus", "Mucus Relief Severe Cold", "Mucus Relief Severe Cold", "Mucus Relief Severe Cold", "Mucus Relief Severe Cold", "Mucus Relief Severe Cold", "Mucus Relief Severe Cold Daytime Cold and Flu Nighttime", "Mucus Relief Severe Cold Daytime Maximum Strength", "Mucus Relief Severe Cold Daytime Maximum Strength", "Mucus Relief Severe Congestion and Cold", "Mucus Relief Severe Congestion and Cold", "Mucus Relief Severe Congestion and Cold", "Mucus Relief Severe Congestion and Cold Max Maximum Strength", "Mucus Relief Severe Congestion and Cough", "Mucus Relief Severe Congestion and Cough", "Mucus Relief Severe Congestion and Cough Maximum Strength", "Mucus Relief Severe Congestion and Cough Maximum Strength", "Mucus Relief Severe Congestion and Cough Maximum Strength", "Mucus Relief Severe Congestion and Cough Maximum Strength", "Mucus Relief Severe Congestion and Cough Maximum Strength", "Mucus Relief Severe Congestion and Cough Maximum Strength", "Mucus Relief Severe Congestion and Cough Maximum Strength", "Mucus Relief Severe Congestion and Cough Maximum Strength", "Mucus Relief Severe Congestion and Cough Maximum Strength", "Mucus Relief Severe Congestion and Cough Maximum Strength", "Mucus Relief Severe Congestion and Cough Maximum Strength", "Mucus Relief Severe Congestion and Cough Maximum Strength", "Mucus Relief Severe Congestion and Cough Maximum Strength", "Mucus Relief Severe Congestion and Cough Maximum Strength", "Mucus Relief Severe Congestion and Cough Maximum Strength", "Mucus Relief Severe Congestion and Cough Maximum Strength", "Mucus Relief Severe Congestion and Cough Maximum Strength", "Mucus Relief Severe Congestion and Cough Maximum Strength", "Mucus Relief Severe Congestion and Cough Maximum Strength", "Mucus Relief Severe Congestion and Cough Maximum Strength", "Mucus Relief Severe Congestion and Cough Multi Symptom Relief", "Mucus Relief Severe Congestion and Sinus", "Mucus Relief Severe Congestion Cough Maximum Strength", "Mucus Relief Severe Congestion Cough Night Time Cold and Flu Maximum Strength", "Mucus Relief Severe Cough and Congestion", "Mucus Relief Severe Sinus Congestion", "Mucus Relief Sinus Pressure Pain and Cough", "Mucus Relief Sinus Pressure Pain and Cough", "Mucus Relief Sinus Pressure Pain and Cough", "Mucus Relief Sinus Pressure Pain and Cough", "Mucus Relief Sinus Pressure Pain and Cough", "Mucus Relief Sinus Pressure, Pain and Cough", "Mucus Relief With Dextromethorphan", "Mucus Relief Xpect", "Mucus Relief Xpect", "Mucus Relief Xpect", "Mucus Relief, Cold, Flu and Sore Throat Maximum Strength, Multi-Symptom", "Multi Symptom Cold", "Multi Symptom Cold", "Multi Symptom Cold", "Multi Symptom Cold", "Multi Symptom Cold and Flu Relief Nighttime", "Multi Symptom Cold and Multi Symptom Nighttime Cold Childrens", "Multi Symptom Cold and Multi Symptom Nighttime Cold Childrens", "Multi Symptom Cold CF", "Multi Symptom Cold CF", "Multi Symptom Cold CF", "Multi Symptom Cold CF Adult", "Multi Symptom Cold Childrens", "Multi Symptom Cold Childrens Plus", "Multi Symptom Cold Double Max Power", "Multi Symptom Cold Plus Childrens", "Multi Symptom Cold Plus Childrens Pain Relief", "Multi Symptom Cold Relief CF Non Drowsy", "Multi Symptom Cold Relief Childrens", "Multi Symptom Daytime", "Multi Symptom Fever and Cold Childrens", "Multi Symptom Flu Relief Max Strength Daytime Nighttime Combo Pack", "Multi Symptom Flu Relief Max Strength Daytime Nighttime Combo Pack", "Multi symptom Nighttime cold and flu relief", "Multi Symptom Nitetime", "Multi Symptom Severe Cold", "Multi Symptom Severe Cold", "Multi Symptom Severe Cold and Nighttime Severe Cold and Cough", "Multi Symptom Severe Cold and Nighttime Severe Cold and Cough", "Multi Symptom Severe Cold and Nighttime Severe Cold and Cough", "Multi Symptom Wal Flu Severe Cold", "Multi Sympton Cold Day Night", "Multi Sympton Cold Day Night", "Multi Sympton Cold Day Night", "Multi Sympton Cold Day Night", "Multi- Symptom Relief DayTime", "Multi-Symptom Cold", "Multi-Symptom Cold", "Multi-Symptom Cold and Cough Daytime Nighttime", "Multi-Symptom Cold and Fever Childrens", "Multi-Symptom Cold and Flu DayTime", "Multi-Symptom Cold and Flu DayTime", "Multi-symptom Cold and Flu Relief Daytime", "Multi-symptom Cold and Flu Relief Daytime Nighttime", "Multi-symptom Cold and Flu Relief Daytime Nighttime", "Multi-symptom Cold and Flu Relief Nighttime", "Multi-Symptom Cold and Flu-Kids", "Multi-Symptom Cold childrens", "Multi-Symptom Cold Daytime", "Multi-Symptom Cold Daytime", "Multi-Symptom Cold Flu and Sore Throat Maximum Strength", "Multi-Symptom Cold Flu and Sore Throat Maximum Strength", "Multi-Symptom Cold Relief", "Multi-Symptom Cold Relief", "Multi-Symptom Cold Relief", "Multi-Symptom Cold Relief", "Multi-Symptom Cold Relief", "Multi-Symptom Cold Relief", "Multi-Symptom Cold Relief", "Multi-Symptom Cold Relief", "Multi-Symptom Cold Relief", "Multi-Symptom Cold Relief", "Multi-Symptom Cold Relief", "Multi-Symptom Cold Relief", "Multi-Symptom Cold Relief Daytime", "Multi-Symptom Cold Relief Daytime, Nighttime", "Multi-Symptom Cold Relief Daytime, Nighttime", "multi-symptom cold relief Daytime, Nighttime", "multi-symptom cold relief Daytime, Nighttime", "Multi-Symptom Cold Severe, Non-Drowsy, Daytime", "Multi-Symptom Cold Warming Effect Daytime", "Multi-symptom Daytime", "Multi-symptom Daytime", "Multi-symptom Daytime", "Multi-symptom Daytime", "Multi-symptom Daytime", "Multi-symptom Daytime", "Multi-symptom Daytime", "Multi-symptom Daytime", "Multi-symptom Daytime", "Multi-symptom Daytime", "Multi-symptom Daytime", "Multi-symptom Daytime", "Multi-symptom Daytime", "Multi-symptom Daytime", "Multi-Symptom Daytime and Nighttime Cold and Flu Relief Plus", "Multi-Symptom Daytime and Nighttime Cold and Flu Relief Plus", "Multi-Symptom Daytime Cold", "Multi-Symptom Daytime Cold", "Multi-Symptom Daytime Cold", "Multi-Symptom Daytime Cold Rapid Release", "Multi-Symptom Flu HBP", "Multi-Symptom Mapap Cold Formula", "Multi-Symptom Mapap Cold Formula", "Multi-symptom Nighttime", "Multi-Symptom Nighttime Cold", "Multi-Symptom Nitetime", "Multi-symptom Nitetime", "Multi-symptom Nitetime", "Multi-symptom Nitetime", "Multi-symptom Nitetime", "Multi-symptom Nitetime", "Multi-symptom Nitetime", "Multi-symptom Nitetime", "Multi-Symptom Relief Cold and Flu Multi-Symptom Relief", "Multi-Symptom Severe Cold", "MyHist DM", "Myphetane DX", "N - Time", "Nasohist DM Pediatric", "Nasohist DM Pediatric", "Neo Citran Daycaps Extra Strength - Caplet", "Neo DM", "Neo DM DROPS DM", "Neo Tuss Syr", "Neocitran Cold & Cough Night", "Neocitran Cold & Flu Syrup", "Neocitran Cough & Cold Syrup", "Neocitran Extra Strength Cold & Cough", "Neocitran Extra Strength Total Cold", "Neocitran Thin Strips Cough", "Neocitran Thin Strips Daytime Cough and Cold", "Neocitran Total Cold", "Neocitran Ultra Strength Total Flu", "Neocitran Ultra Strength Total Flu Night", "Neogen-D", "Neutrahist PDX Drops", "Neutrahist PDX Drops", "NEXT COLD and FLU DAYTIME", "NEXT COLD and FLU NIGHTTIME", "Next Day Time Non drowsy Cold and Flue", "Next Day Time Non drowsy Cold and Flue", "Next Night Severe Cold, Flu and Sore Throat", "Next Night Time Cold and Flu Relief", "Next Night Time Cold and Flu Relief", "NEXT Severe Cold, Flu and Sore Throate Night Max Strength", "Nicold Medicine for Adults", "Night Cold and Flu Relief", "Night Cold Flu Cough and Allergy", "Night Relief", "Night Relief Cold and Flu Liquid Capsules", "Night Relief Cough", "Night Relief Free", "Night Relief Free", "Night Relief Free", "Night Relief Multi Symptom Cold and Flu", "Night Time", "Night Time", "Night Time", "Night Time", "Night Time", "Night Time", "Night Time Caps Cold Flu Multi symptom", "Night Time Cherry", "Night Time Cherry", "Night Time Cherry", "Night Time Cherry", "Night Time Cherry Pseudo-Free", "Night Time Cherry Pseudo-Free", "Night Time Cherry Pseudo-Free", "Night Time Cherry Pseudo-Free", "Night Time Cherry Pseudo-Free", "Night Time Cherry Pseudo-Free", "Night Time Cherry Pseudo-Free", "Night Time Cherry Pseudo-Free", "Night Time Cherry Pseudo-Free", "Night Time Cherry Pseudo-Free", "Night Time Cherry Pseudo-Free", "Night Time Cherry Pseudo-Free", "Night Time Cherry Pseudo-Free", "Night Time Cherry Pseudo-Free", "Night Time Cherry Pseudo-Free", "Night Time Cherry Pseudo-Free", "Night time cold and flu", "Night Time Cold and Flu", "Night Time Cold and Flu", "Night Time Cold and Flu", "Night Time Cold and Flu", "Night Time Cold and Flu", "Night Time Cold and Flu", "Night time cold and flu", "Night time cold and flu", "Night Time Cold and Flu", "Night Time Cold and Flu", "Night Time Cold and Flu", "Night Time Cold and Flu", "NIGHT TIME COLD and FLU CHERRY", "NIGHT TIME COLD and FLU FORMULA", "Night Time Cold and Flu Multi Symptom", "Night time cold and flu multi symptom", "Night time cold and flu multi symptom", "Night Time Cold and Flu Multi Symptom", "Night Time Cold and Flu Original", "Night Time Cold and Flu original", "Night Time Cold and Flu ReadyInCase", "Night Time Cold and Flu Relief", "Night Time Cold and Flu Relief", "Night Time Cold and Flu Relief", "Night Time Cold and Flu Relief", "Night Time Cold and Flu Relief Multi Symptom", "Night Time Cold and Flu Relief Multi Symptom", "Night Time Cold and Flu Relief Multi Symptom", "Night Time Cold and Flu Relief Multi Symptom", "Night Time Cold and Flu Relief Multi Symptom", "Night Time Cold and Flu Relief Multi Symptom", "Night Time Cold and Flu Relief Multi Symptom", "Night Time Cold and Flu Relief Multi Symptom", "Night Time Cold and Flu Relief Multi Symptom", "Night Time Cold and Flu Relief Multi Symptom", "Night Time Cold and Flu Relief Multi Symptom", "Night Time Cold and Flu Relief Multi Symptom", "Night Time Cold and Flu Relief Multi Symptom", "Night Time Cold and Flu Relief Multi Symptom", "Night Time Cold and Flu Relief Multi Symptom", "Night Time Cold and Flu Relief Multi Symptom", "Night Time Cold and Flu Relief Multi Symptom", "Night Time Cold and Flu Relief Multi Symptom", "Night Time Cold and Flu Relief Multi Symptom", "Night Time Cold and Flu Relief Multi Symptom", "Night Time Cold and Flu Relief Multi Symptom", "Night Time Cold and Flu Severe", "Night Time Cold and Flue Relief", "Night Time Cold Max", "Night Time Cold Multi-Symptom", "Night Time Cold/Flu Relief Cherry", "Night Time Cold/Flu Relief Cherry", "Night Time Cold/Flu Relief Cherry", "Night time cold/flu relief multi symptom", "Night Time Cold/Flu Relief Original", "Night Time Cold/Flu Relief Original", "Night Time Cold/Flu Relief Original", "Night Time Cough", "Night Time Cough", "Night Time Cough", "Night Time Cough", "Night Time Cough", "Night Time Cough", "Night Time Cough", "Night Time Cough", "Night Time Cough", "Night Time Cough", "Night Time Cough and Sore Throat Cool Blast", "Night Time Cough Cherry", "Night Time Cough Cherry", "Night Time Cough Cherry", "Night Time Cough Cherry", "Night Time Cough cherry", "Night Time Cough Cherry", "Night Time Cough Cherry", "Night Time Cough Relief", "Night Time Day Time", "Night Time Day Time", "Night Time Gelcap", "Night time multi symptom cold/flu relief", "Night Time Multi Symptom Flu Cold Medicine", "Night Time Multi Symptom Relief", "Night time Multi Sympton Cold Max", "Night Time MULTI-SYMPTOM COLD/FLU RELIEF", "Night Time Original Pseudo-Free", "Night Time Original Pseudo-Free", "Night Time Original Pseudo-Free", "Night Time Original Pseudo-Free", "Night Time Original Pseudo-Free", "Night Time Original Pseudo-Free", "Night Time Original Pseudo-Free", "Night Time Original Pseudo-Free", "Night Time Original Pseudo-Free", "Night Time Original Pseudo-Free", "Night Time Original Pseudo-Free", "Night Time Original Pseudo-Free", "Night Time Pseudo-Free", "Night Time Pseudo-Free", "Night Time Relief", "Night Time Severe Cold and Flu", "Night Time Severe Cold and Flu Relief", "Night Time Softgels", "Night Time Total Extra Strength", "Night-Time Cherry MULTI-SYMPTOM COLD/FLU RELIEF", "Night-Time Cold and Flu Relief", "Night-Time COUGH RELIEF", "NIGHT-TIME MULTI-SYMPTOM COLD/FLU Cherry", "NIGHT-TIME MULTI-SYMPTOM COLD/FLU Original", "Night-Time Multi-Symptom Cold/Flu Relief", "Night-Time Original MULTI-SYMPTOM COLD/FLU RELIEF", "Nightcap Cold & Flu Liquid Gels", "Nightcap Cold and Flu Liquid Gels", "Nightcap Complete Liquid Gels", "Nightcap Complete Liquid Gels", "Nightime", "Nightime Cold and Flu", "Nightime Cold and Flu", "NightRelief DayRelief", "NightRelief DayRelief", "NightRelief Free Multi symptom cold flu", "Nighttime", "Nighttime", "Nighttime", "NightTime", "NightTime", "NightTime", "Nighttime", "NightTime", "Nighttime 325 Liqua Caps", "Nighttime Childrens Multi Symptoms Cold and Cough Multi-Symptom Relief", "Nighttime Cold", "NightTime Cold", "Nighttime Cold & Flu Liquid Capsules", "Nighttime Cold & Flu Liquid Capsules", "Nighttime Cold & Flu Relief", "Nighttime Cold & Flu Relief", "Nighttime Cold & Flu Relief", "Nighttime Cold & Flu Relief", "Nighttime Cold & Flu Relief Liquid Gels", "Nighttime Cold & Flu Relief Syrup", "Nighttime Cold & Sinus", "Nighttime cold and flu", "Nighttime Cold and Flu", "NightTime Cold and Flu", "Nighttime Cold and Flu", "Nighttime Cold and Flu", "Nighttime Cold and Flu", "Nighttime Cold and Flu", "NightTime Cold and Flu", "Nighttime cold and flu", "Nighttime Cold and Flu", "Nighttime Cold and Flu", "Nighttime Cold and Flu", "Nighttime Cold and Flu", "Nighttime cold and flu", "Nighttime Cold and Flu", "Nighttime Cold and Flu", "Nighttime Cold and Flu", "Nighttime Cold and Flu", "NIGHTTIME COLD and FLU", "Nighttime Cold and Flu", "Nighttime Cold and Flu", "NIGHTTIME COLD and FLU", "Nighttime Cold and Flu", "Nighttime Cold and Flu", "Nighttime Cold and Flu", "Nighttime Cold and Flu", "Nighttime Cold and Flu", "NightTime Cold and Flu", "Nighttime Cold and Flu", "Nighttime Cold and Flu", "Nighttime Cold and Flu", "Nighttime Cold and Flu", "Nighttime Cold and Flu", "Nighttime Cold and Flu", "Nighttime Cold and Flu", "Nighttime Cold and Flu", "Nighttime Cold and Flu", "NightTime Cold and Flu", "Nighttime Cold and Flu Cherry", "Nighttime Cold and Flu cherry", "Nighttime Cold and Flu Extra Strength Medicine", "Nighttime Cold and Flu Lil Drug Store Products", "Nighttime Cold and Flu Liquid Capsules", "Nighttime Cold and Flu Liquid Capsules", "Nighttime Cold and Flu Liquid Gels", "NIGHTTIME Cold and Flu Max Softgels MAXIMUM STRENGTH", "Nighttime Cold and Flu Maximum Strength", "NIGHTTIME COLD AND FLU Maximum Strength", "NightTime Cold and Flu Multi Symptom", "NightTime Cold and Flu Multi Symptom", "NightTime Cold and Flu Multi Symptom", "NightTime Cold and Flu Multi Symptom", "NightTime Cold and Flu Multi Symptom", "Nighttime Cold and Flu original", "Nighttime Cold and Flu ReadyInCase", "Nighttime Cold and Flu ReadyInCase", "Nighttime Cold and Flu Relief", "Nighttime Cold and Flu Relief", "NightTime Cold and Flu Relief", "Nighttime Cold and Flu Relief", "Nighttime Cold and Flu Relief", "Nighttime Cold and Flu Relief", "Nighttime Cold and Flu Relief", "Nighttime Cold and Flu Relief", "Nighttime Cold and Flu Relief", "Nighttime Cold and Flu Relief", "Nighttime Cold and Flu Relief", "Nighttime Cold and Flu Relief", "Nighttime Cold and Flu Relief", "Nighttime Cold and Flu Relief", "Nighttime Cold and Flu Relief", "Nighttime Cold and Flu Relief", "Nighttime Cold and Flu Relief", "Nighttime Cold and Flu Relief", "Nighttime Cold and Flu Relief", "Nighttime Cold and Flu Relief", "Nighttime Cold and Flu Relief", "Nighttime Cold and Flu Relief", "Nighttime Cold and Flu Relief", "Nighttime Cold and flu Relief", "Nighttime Cold and Flu Relief", "Nighttime Cold and Flu Relief", "Nighttime Cold and Flu Relief", "Nighttime cold and flu relief", "Nighttime cold and flu relief", "Nighttime cold and flu relief", "Nighttime Cold and Flu Relief", "Nighttime Cold and Flu Relief", "Nighttime cold and flu relief", "Nighttime Cold and Flu Relief Alcohol Free", "Nighttime Cold and Flu Relief Multi Symptom", "Nighttime Cold and Flu Relief Multi Symptom", "Nighttime Cold and Flu Relief Multi Symptom", "Nighttime Cold and Flu Relief Multi Symptom", "Nighttime Cold and Flu Relief Multi Symptom", "Nighttime Cold and Flu Relief Multi-Symptom", "Nighttime Cold and Flu Relief Multi-Symptom", "Nighttime Cold and Flu Relief Multi-Symptom", "Nighttime Cold and Flu Relief Multi-Symptom", "Nighttime Cold and Flu Relief Plus", "Nighttime Cold and Flu Relief Softgels Multi-symptom", "Nighttime Cold Flu Relief", "Nighttime Cold Flu Relief", "Nighttime Cold Flu Relief", "Nighttime Cold Head Congestion", "Nighttime Cold Max", "Nighttime Cold Medicine", "Nighttime Cold Multi-Symptom Cool Blast", "Nighttime Cold Relief Extra Strength Tablets", "Nighttime Cold Relief Extra Strength Tablets PE", "Nighttime Cold/Flu Relief Softgels", "Nighttime Complete", "Nighttime Cough", "Nighttime Cough", "NightTime Cough", "Nighttime Cough", "Nighttime Cough", "Nighttime Cough all night cough relief", "Nighttime Cough and Sore Throat Liquid", "Nighttime Cough DM", "Nighttime Cough DM", "Nighttime Cough DM Max", "NightTime Cough DM Maximum Strength", "Nighttime Cough Relief", "Nighttime Cough Relief", "Nighttime Cough Relief", "Nighttime Cough Relief Cherry", "Nighttime Cough-Kids", "Nighttime Cough. Cold. Flu Gel Capsules", "Nighttime D Cold and Flu", "Nighttime D Cold and Flu Relief", "Nighttime D Cold and Flu Relief", "Nighttime Daytime Cough", "Nighttime Daytime Cough", "NightTime DayTime Severe Cold and Flu", "NightTime DayTime Severe Cold and Flu", "Nighttime Extra Strength Contac Complete Cough, Cold & Flu", "Nighttime Extra Strength Contac Complete Cough, Cold & Flu Plus Vitamin C", "Nighttime Hbp", "Nighttime HBP Cold and Flu Relief", "Nighttime Liqua Caps", "NightTime Maximum Strength Cold and Flu", "Nighttime multi symptom", "NIGHTTIME Multi Symptom", "Nighttime Multi Symptom Cold and Flu Relief", "Nighttime Multi Symptom Cold and Flu Relief", "Nighttime Multi Symptom Cold and Flu Relief", "Nighttime Multi-Symptom Cold", "Nighttime Multi-Symptom Cold and Flu Relief", "Nighttime Multi-Symptom Cold and Flu Relief", "NightTime Multi-Symptom Flu Cold", "Nighttime Relief Complete", "NightTime Relief Severe Cold and Flu", "Nighttime severe", "Nighttime Severe", "Nighttime Severe", "Nighttime Severe Cold and Flu", "NightTime Severe Cold and Flu", "Nighttime Severe Cold and Flu", "Nighttime SEVERE COLD and FLU", "Nighttime Severe Cold and Flu", "Nighttime Severe Cold and Flu", "Nighttime Severe Cold and Flu", "Nighttime Severe Cold and Flu", "Nighttime Severe Cold and Flu", "Nighttime Severe Cold and Flu Relief", "Nighttime Severe Cold and Flu Relief", "Nighttime Total Super Strength", "Nite Time", "Nite Time", "Nite Time (children's)", "Nite Time Cold and Flu", "Nite Time Cold and Flu", "Nite Time Cold and Flu", "Nite Time Cold and Flu", "Nite Time Cold and Flu", "Nite Time Cold and Flu", "Nite Time Cold and Flu Relief", "Nite time cold and flu relief", "Nite Time Cold Flu Relief", "Nite Time Cold Medicine", "Nite Time Cold Medicine Cherry Flavor", "Nite Time Cold/Flu Relief", "Nite Time Day Time", "Nite Time Day Time", "Nite Time Multi symptom cold flu relief", "Nite Time multi symptom cold flu relief", "Nite Time MULTI SYMPTOM COLD FLU RELIEF", "Nite Time multi symptom cold/flu", "Nite time Severe Cold and Flu Maximum Strength", "Nite-Time Cold and Flu Multi-Symptom Relief", "Nite-Time COLD/FLU Medicine", "Nite-Time COLD/FLU Medicine Cherry", "Nite-Time COLD/FLU ORIGINAL", "Nite-TimeCOLD/FLU CHERRY COLD/FLU CHERRY", "Nitecin", "NiteTime", "Nitetime", "NiteTime", "Nitetime", "Nitetime", "NiteTime Cold and Flu", "Nitetime Cold and Flu", "Nitetime Cold and Flu", "Nitetime Cold and Flu", "Nitetime Cold and Flu", "Nitetime Cold and Flu", "Nitetime Cold and Flu", "NiteTime Cold and Flu", "NiteTime Cold and Flu", "Nitetime Cold and Flu", "Nitetime Cold and Flu", "Nitetime cold and flu relief", "Nitetime cold and flu relief", "NiteTime Cold Flu Relief", "NiteTime Cold Flu Relief", "Nitetime Cold Flu Relief", "Nitetime Cold Medicine", "Nitetime Cold Medicine", "Nitetime Cold Medicine Liq", "Nitetime Cold Medicine Original and Cherry", "NiteTime Cold plus Flu Releif", "Nitetime Cold Relief Extra Strength", "NiteTime Cold/Flu, Multi-Symptom Relief", "NItetime cough", "Nitetime Cough", "Nitetime Cough", "NiteTime Cough DayTime Cough", "NiteTime Cough DayTime Cough", "Nitetime D", "Nitetime D multi symptom cold flu relief", "NiteTime DayTime Cold and Flu", "NiteTime DayTime Cold and Flu", "NiteTime Multi-Symptom Cold/Flu Relief", "Nitetime Severe Cold and Flu Relief", "Niva-Hist DM", "Nivanex DMX", "Nocold-F", "NoHist DM", "Non Drowsy Cold and Cough PE", "Non Drowsy Cold and Cough PE", "Non Drowsy DAY and NIGHT Multi-Symptom Cold and Flu Formula", "Non Drowsy DAY and NIGHT Multi-Symptom Cold and Flu Formula", "Non Drowsy DAY Cold and Flu Plus and NIGHTTIME Cold and Flu Plus", "Non Drowsy DAY Cold and Flu Plus and NIGHTTIME Cold and Flu Plus", "Non Drowsy Day Time cold and Flu Relief", "Non Drowsy Daytime and Nighttime Cold and Flu", "Non Drowsy Daytime and Nighttime Cold and Flu", "Non Drowsy DAYTIME and NIGHTTIME Sinus Congestion and Cough Relief", "Non Drowsy DAYTIME and NIGHTTIME Sinus Congestion and Cough Relief", "Non Drowsy DAYTIME and NIGHTTIME Sinus Congestion and Cough Relief", "Non Drowsy DAYTIME and NIGHTTIME Sinus Congestion and Cough Relief", "Non Drowsy Daytime Cold and Flu Softgel", "Non Drowsy Nighttime Cold and Flu Softgel", "Non Drowsy Regular Strength Contac Complete", "Non Drowsy Severe Daytime and Nighttime Cold and Flu Relief", "Non Drowsy Severe Daytime and Nighttime Cold and Flu Relief", "Non Drowsy Super Strength Contac Complete", "Non-drowsy Day Time", "NON-DROWSY DAYTIME Cold and Flu Max Softgels MAXIMUM STRENGTH", "Non-Drowsy DayTime Cold and Flu Multi-Symptom Relief", "Non-Drowsy Daytime Multi Symptom Cold and Flu Relief", "Non-Drowsy Daytime Multi-Symptom Cold and Flu", "Non-Drowsy Daytime Severe Cold Multi-Symptom", "Non-Drowsy Formula Wal-Tussin", "Non-Drowsy Max Cold", "NorelCS CS", "Novahistex DM - Liq 15mg/5ml", "Novahistex DM Expectorant With Decongestant", "Novahistex DM With Decongestant", "Novahistine DM - Liq 7.5mg/5ml", "Novahistine DM Expectorant With Decongestant", "Novahistine DM With Decongestant - Liq", "Novalgina Children Cough and Cold", "Novalgina Children Cough and Cold", "Novalgina Pediatrico Cough and Cold Pediatrico", "Nuedexta", "Nuedexta", "Nyquil Cold & Flu Alcohol Free", "NyQuil Cold and Flu", "Nyquil Cold Flu", "Nyquil Cold Flu", "Nyquil Cold Flu", "Nyquil Cold Flu Relf Cherry", "Nyquil Cold Flu Relf Cherry", "Nyquil Cold Flu Relf Cherry", "Nyquil Complete", "Nyquil Complete + Vicks Vapocool", "Nyquil Complete + Vicks Vapocool Cold & Flu Liquid", "Nyquil Cough DM + Congestion", "Nyquil Honey", "Nyquil Kids", "Nyquil Kids Honey", "Nyquil Liquicaps", "NyQuil Severe", "NyQuil Severe Cold and Flu", "NyQuil Severe Cold and Flu", "Nyquil Severe Cold Flu", "Nyquil Severe Cold Flu", "Nyquil Severe Cold Flu", "NyQuil Severe Plus VapoCOOL Cold and Flu", "NyQuil Severe plus Vicks VapoCool", "NyQuil Severe plus Vicks VapoCool Cold and Flu", "NyQuil Severe Plus Vicks Vapocool Cold and Flu", "NyQuil Severe VapoCool", "NyQuil VapoCOOL SEVERE COLD and FLU plus CONGESTION", "Only For COLD AND FLU COUGH SUPPRESSANT", "Only For COUGH", "Original Night-Time MULTI-SYMPTOM COLD/FLU RELIEF", "Ornade DM 10 Liq", "Ornade DM 15 Liq", "Ornade DM 30 Liq", "Our Family day time severe cold and Cough berry infused with menthol and green tea flavors", "Overnight Cold and Flu", "Overnight Cold and Flu", "P-Tuss DM", "P.M. Cold Relief Formula", "Pain & Fever + Cold & Cough", "Pain Relief Cold", "Pain Relief Cold Multi Symptom", "Pain Relief Non-Drowsy, Daytime", "Pain Relief Plus", "Pain Relief Plus Multi Symptom Cold Childrens", "Pain Reliever Fever Reducer", "Palagrip", "Panatuss DXP", "Panatuss Pediatric Drops DXP", "Panto Flu", "PE Hist DM", "PE multi-stymptom cold and cough relief", "Pecgen Dmx", "Pecgen DMX", "PECGEN PSE Cough Suppressant Expectorant Nasal Decongestant GRAPE Flavor", "Pedia Relief", "Pedia Relief", "Pedia Relief", "Pediacare Childrens Cough and Cold Grape", "PediaCare Childrens Cough and Congestion", "Pediacare Childrens Cough And Congestion", "Pediacare Childrens Cough and Congestion Grape", "PediaCare Childrens MultiSymptom Cold", "PediaCare Childrens Plus Cough and Runny Nose", "PediaCare Childrens Plus Cough and Sore Throat", "PediaCare Childrens Plus Flu", "PediaCare Childrens Plus Multisymptom Cold", "PediaCare LongActing Cough", "PediaCare Multi Symptom Cold", "PediaCare Plus Multisymptom Cold", "Pediacare-Cough-RunnyNose", "Pediatex TDM", "Pediatric Cough and Cold Medicine", "Pediatric Cough and Cold Medicine", "Pediatric Cough Syrup", "Pentrexcilina", "Pentrexcilina", "Pentrexcilina Night Time", "Permavan External Patch", "Personnelle Contre Le Rhume Liq", "Personnelle DM Syr", "Pharbinex-DM", "Pharbinex-DM", "Pharmacol DM Syr", "Pharmilin-DM Syr 15mg/5ml", "Pharminicol DM Syrup", "Pharminil DM Sugar-free Liq 15mg/5ml", "Pharminil DM Syr 15mg/5ml", "Pharmitussin DM", "Phenagil", "Phenagil", "Phenylephrine Complex", "Physicians Care Cold and Cough", "Physicians Care Cold and Cough", "Physicians Care Cold Cough", "PhysiciansCare Cold and Cough Non-Drowsy", "PhysiciansCare Cold and Cough Non-Drowsy", "Plus Multi Symptom Cold Childrens Pain Relief", "PMS-dextromethorphan Hydrobromide Syr 3mg/ml", "Poly-Hist DM", "Poly-tussin DM", "Poly-Vent DM", "Polytussin DM", "Polytussin DM", "Polytussin DM", "Preferred Plus Chest Congestion Relief DMTDM TDM", "Preferred Plus Childrens Mucus Relief Multi Symptom Cold", "Preferred Plus Cough DM", "Preferred Plus Day Time Cold and Flu", "Preferred Plus Intense Cough Reliever", "Preferred Plus Mucus Relief", "Preferred Plus Severe Cold", "Preferred Plus Severe Cold Cough and Flu", "Preferred Plus Severe Cold Day Time Cold and Flu Night Time", "Preferred Plus Severe Day Time", "Preferred Plus Severe Nite Time", "Preferred Plus Severe Sinus Congestion", "Preferred Plus TabTussin DM DMTDM", "Premier Value", "Premier Value Chest Congestion and cough releif DM", "Premier Value day time severe cold and cough berry infused with menthol and green tea flavors", "Premier Value Maximum Strength", "Premier Value Multi-Symptom Severe Cold Green Tea and Honey Lemon flavors", "Premier Value Multi-Symptom Severe Cold Green Tea and Honey Lemon flavors", "Premier Value Multi-Symptom Severe Cold Green Tea and Honey Lemon flavors", "Premier Value Tussin Cough Long Acting", "Presgen", "Presgen B", "Presgen Pediatric", "Pressure and Pain and Cold", "Pressure and Pain and Cold", "Pressure and Pain PE Plus Cold", "Pressure and Pain PE plus Cough", "Pressure and Pain Plus Cold PE", "Pressure and Pain Plus Cough PE", "pressure and pain sinus relief PE NON-DROWSY", "Pressure Pain and Cold Suphedrine PE", "Pressure Pain Cold", "Pressure Pain Cold", "Pressure Pain Cold PE", "Pressure Pain Cough PE", "Pressure Plus Pain PE Plus Cold", "Pressure Plus Pain PE Plus Cold", "Pressure plus Pain PE plus Cough", "Pressure Plus Pain PE Plus Cough", "Primary Health - Fast Maximum Cold, Flu and Sore Throat Relief", "Prime's Sore Throat, Cough and Colds Capsules", "Promatussin DM Adult Formula Syr", "Promatussin DM Children Formula", "Prometh with Dextromethorphan", "Promethazine DM", "Promethazine DM", "Promethazine DM", "Promethazine DM", "Promethazine DM", "Promethazine DM", "Promethazine DM", "Promethazine DM", "Promethazine DM", "Promethazine DM", "Promethazine DM", "Promethazine DM", "Promethazine DM", "Promethazine DM", "Promethazine DM", "Promethazine DM", "Promethazine HCl and Dextromethorphan Hydrobromide", "Promethazine Hydrochloride and Dextromethophan Hydrobromide", "Promethazine Hydrochloride and Dextromethorphan Hydrobromide", "Promethazine Hydrochloride and Dextromethorphan Hydrobromide", "Promethazine Hydrochloride and Dextromethorphan Hydrobromide", "Promethazine Hydrochloride and Dextromethorphan Hydrobromide", "Promethazine Hydrochloride and Dextromethorphan Hydrobromide", "Promethazine Hydrochloride and Dextromethorphan Hydrobromide", "Promethazine Hydrochloride and Dextromethorphan Hydrobromide", "Promethazine Hydrochloride and Dextromethorphan Hydrobromide", "Promethazine Hydrochloride and Dextromethorphan Hydrobromide", "Promethazine Hydrochloride and Dextromethorphan Hydrobromide", "Promethazine Hydrochloride and Dextromethorphan Hydrobromide", "Promethazine Hydrochloride and Dextromethorphan Hydrobromide Oral", "Promethazine Hydrochloride and Dextromethorphan Hydrobromide Oral", "Promethazine Hydrochloride and Dextromethorphan Hydrobromide Oral Solution", "Promethazine Hydrochloride and Dextromethorphan Hydrobromide Oral Solution", "Promethazine Hydrochloride and Dextromethorphan Hydrobromide Oral Solution", "Promethazine Hydrochloride and Dextromethorphan Hydrobromide Oral Solution", "Promethazine Hydrochloride and Dextromethorphan Hydrobromide Oral Solution", "Publix Cherry Flavor Nitetime", "Pulmo Calcio", "Pulmorex DM Syr", "Pulmorphan", "Pulmorphan Pediatrique", "Pulmovac", "Pyril DM", "Pyril Mal Phenyl HCl Dex HBr", "Q Tapp Cold and Cough", "Q Tapp Cold and Cough", "Q Tussin DM", "Q Tussin DM", "Q Tussin DM", "Q Tussin DM", "Q Tussin DM", "Q Tussin DM", "Q-Tapp DM", "Q-Tapp DM Elixir", "Quality Choice day time severe cold and cough berry infused with menthol and green tea flavors", "Quality Choice Daytime Severe Cold and Cough Berry infused with Menthol and Green Tea flavors", "Quality Choice Mucus Relief DM DM", "Quality Choice Multi-Symptom, Non-Drowsy DayTime Cold and Flu", "Quality Choice Nighttime Cold and Flu", "Quartuss", "Quartuss DM", "Rabofen DM", "Rabofen DM", "Rabofen DM", "Rabofen DM", "Rabofen DM", "Rapid Action Cold", "Rapid Max Maximum Strength Cool and Clear - Cold, Flu and Sore throat", "Rapid Max Maximum Strength Cool and Clear - Cold, Severe Congestion and Cough", "Re Dcp Drops", "Reeses TABtussin DM", "Refenesen Mucus Relief DM", "Reg.str.cold Medic.(night Time Relief)caplet", "Regular Strength Cold Medication(daytime R.)", "Regular Strength Tylenol Cold and Flu Powder", "Regular Strength Tylenol Cold Chest Congestion", "Regular Strength Tylenol Cold Daytime", "Regular Strength Tylenol Cold Daytime", "Regular Strength Tylenol Cold Nighttime", "Regular Strength Tylenol Cold Nighttime Caplet", "Regular Strength Tylenol Cough Suspension", "Regular Strength Tylenol Cough Suspension With Decongestant", "RelCof DM", "Relhist DMX", "Reme Hist DM", "Rescon DM", "Resfridol Antitussive", "Rexall Daytime Nighttime Cold and Flu", "Rexall Daytime Nighttime Cold and Flu", "Rexall Daytime Nighttime Cold Flu", "Rexall Daytime Nighttime Cold Flu", "Rexall DM Cough and Congestion Relief", "Rexall DM Cough and Congestion Relief", "Rexall Night Time Cold and Flu", "Rexall Night Time Cold and Flu", "Rhume Extra Fort Jour", "Rhume Extra Fort Nuit", "Right Remedies Adult Long Lasting Cough Relief Softgel", "Rite Aid day time severe cold and cough berry infused with menthol and green tea flavors", "Rite Aid Daytime Severe Cold and Cough Relief", "Rite Aid Mixed Berry Sore Throat and Cough Lozenge", "Ritussin DM", "Robafen", "Robafen", "Robafen", "Robafen", "Robafen", "Robafen CF Cough and cold", "Robafen Cough Liquidgels", "Robafen Cough Non-Drowsy Formula", "Robafen DM", "Robafen DM", "Robafen DM", "Robafen DM", "Robafen DM", "Robafen DM Cough Sugar Free Clear", "Robafen DM Cough Sugar Free Clear", "Robafen DM Max Non drowsy", "Robafen DM Peak Cold Sugar-free Cough Plus Chest Congestion DM", "Robi DM Max Cough Congestion 10ct Blister", "Robitussin 12 Hour Cough Relief", "Robitussin 12 Hour Cough Relief", "Robitussin 12 Hour Cough Relief", "Robitussin 12 Hour Cough Relief", "Robitussin CF", "Robitussin Children's", "Robitussin Children's Cough & Cold Bedtime", "Robitussin Children's Cough and Cold", "Robitussin Complete Daytime", "Robitussin Complete Nighttime", "Robitussin Cough and Chest Congestion DM", "Robitussin Cough and Chest Congestion DM Max", "Robitussin Cough and Chest Congestion Sugar Free DM", "Robitussin Cough and Cold", "Robitussin Cough and Cold CF", "Robitussin Cough and Cold CF Max", "Robitussin Cough and Cold D", "Robitussin Cough and Cold D", "Robitussin Cough and Cold Liqui-gels", "Robitussin Cough and Cold Long Acting", "Robitussin Cough Control", "Robitussin Cough Gels Long-acting", "Robitussin Cough Long-acting", "Robitussin Cough Plus Chest Congestion DM", "Robitussin Cough, Cold & Flu Liqui-gels", "Robitussin Direct Cough", "Robitussin DM Coughgels Liqui-gels Toux", "Robitussin Elderberry Maximum Strength Cough plus Chest Congestion DM", "Robitussin Extra Strength Cough & Cold", "Robitussin Extra Strength Cough Control", "Robitussin Extra Strength Honey Cough & Congestion", "Robitussin Honey Children's Cough & Congestion", "Robitussin Honey Cough & Cold Nighttime", "Robitussin Honey Cough and Cold", "Robitussin Honey Cough DM", "Robitussin Honey Flu", "Robitussin Honey Maximum Strength Cough and Chest Congestion DM", "Robitussin Honey Maximum Strength Nighttime Cough DM", "Robitussin Honey Severe Cough, Flu Plus Sore Throat", "Robitussin Lingering Cold Long-acting Cough", "Robitussin Lingering Cold Long-acting Coughgels", "Robitussin Long-acting Coughgels", "Robitussin Maximum Strength 12 Hour Cough and Mucus Relief", "Robitussin Maximum Strength Cough Plus Chest Congestion DM", "Robitussin Maximum Strength Cough Plus Chest Congestion DM", "Robitussin Maximum Strength Nighttime Cough DM", "Robitussin Maximum Strength Nighttime Cough DM", "Robitussin Maximum Strength Severe Cough Plus Sore Throat", "Robitussin Maximum Strength Severe Multi-Symptom 7 in 1 Relief Nighttime", "Robitussin Medi-Soothers", "Robitussin Medi-Soothers", "Robitussin Medi-Soothers Cough DM", "Robitussin Night Time Cough, Cold and Flu", "Robitussin Peak Cold Cough Plus Chest Congestion DM", "Robitussin Peak Cold Daytime Cold Plus Flu", "Robitussin Peak Cold Maximum Strength Cough Plus Chest Congestion DM", "Robitussin Peak Cold Maximum Strength Multi-symptom Cold", "Robitussin Peak Cold Multi-Symptom Cold", "Robitussin Peak Cold Nighttime Cold Plus Flu", "Robitussin Peak Cold Sugar-Free Cough Plus Chest Congestion DM", "Robitussin Severe Multi-Symptom Cough Cold Flu", "Robitussin Sugar Free Cough Control", "Robitussin Sugar-Free Dye-Free Cough Plus Chest Congestion DM", "Robitussin To Go Cough and Chest Congestion DM", "Robitussin To Go Cough and Cold CF", "Robitussin Tos Seca", "Robitussin Total Cough, Cold & Flu", "Robitussin Total Cough, Cold & Flu Nighttime Extra Strength", "Robo Cough", "Robo Cough", "Robo Cough", "Robo Cough", "RoboHBr Cough SUPPRESSANT", "RoboTablets", "Rompe Pechito DM for Kids", "Rompe Pecho CF", "Rompe Pecho DM", "Rompe Pecho Max Multi Symptoms", "Rompe Pecho Nighttime", "Rompe Pecho SF FLU", "Rompe Tos X Adults", "Rompe Tos X Children", "Rondamine DM", "Ru-hist Plus", "Rugby Chest Congestion Relief DM", "Rugby Chest Congestion Relief DM", "Rugby Cough", "Rugby Cough", "Rugby Cough", "Rugby Cough Syrup", "Rugby Cough Syrup", "Rugby Mucus Relief DM", "Runny Nose and Cough", "Runny Nose and Cough", "Rx Act Cold Head Congestion", "Rx Act Cough and Sore Throat", "Rx Act Cough and Sore Throat", "Rx Act Flu and severe cold and cough daytime", "Rx Act Nighttime Cold Flu Relief Multi Symptom", "Rx Act Tussin CF Cough and Cold", "RX Act Tussin Cough", "Rycontuss Cherry Flavor", "Rynex DM", "Safetussin CD", "Safetussin DM", "Safetussin DM", "Safetussin DM", "Safetussin DM", "Safetussin High Blood Pressure and diabetes Cough, Cold and Flu", "SAFETUSSIN Non Drowsy Cough plus chest congestion", "Safetussin PM", "Safetussin PM", "Safetussin PM", "Safetussin PM Nighttime Cough relief", "Safeway Daytime Cold and Flu Relief", "Safeway Nighttime Cold and Flu", "Safrel Cough Relief", "sanaflu Night-Time Xtreme Multi-Symptom Cold/Flu Relief Cherry Flavor", "Sanaflu Nighttime Xtreme Multi Symptom Cold Flu Relief Cherry Flavor", "Sanaflu Xtra", "Sanatos", "SanaTos Boost", "SanaTos Children Cough and Congestion Cherry", "SanaTos Childrens Mucus Relief Cough", "SanaTos COLD Multi-Symptom", "SanaTos COLD Multi-Symptom", "Sanatos Day", "SanaTos Day and Night Multi Symptom", "SanaTos Day and Night Multi Symptom", "Sanatos Lozenges EX", "SanaTos Mucus Relief Cold Toddlers", "SanaTos Multi Symptom", "SanaTos Multi Symptom", "Sanatos Multi Symptom Daytime", "Sanatos Night", "Sanatos Nighttime Multi Symptoms", "SanaTos Severe Cold and Cough Day Time", "SanaTos Turbo Max Strength", "SanaTos X", "Scot-Tussin Diabetes Cough Formula with DM", "Scot-Tussin Diabetes Cough Formula with DM", "Scot-Tussin Diabetes Cough Formula with DM", "Scot-Tussin DM Maximum Strength Cough Suppressant and Cold Relief", "Scot-Tussin DM SF Maximum Strength Cough Cold", "Scot-Tussin Senior Maximum Strength Cough Suppressant and Expectorant", "Scot-Tussin Senior SF DMEXP", "Sedalmex XL Flu", "Sedatuss DM Sirop 15mg/5ml", "Select Brand Mucus Relief DM", "Select Brand Tab Tussin DM", "Sever Daytime Cold and Flu and Sever Nighttime Cold and Flu", "Sever Daytime Cold and Flu and Sever Nighttime Cold and Flu", "Severe Cold", "Severe Cold", "Severe Cold", "Severe Cold", "Severe Cold", "Severe Cold", "Severe Cold", "Severe Cold", "Severe Cold and Cough Daytime", "Severe Cold and Cough Daytime", "Severe Cold and Cough Daytime", "Severe Cold and Cough Daytime", "Severe cold and cough relief", "Severe Cold and Cough Relief Daytime", "Severe Cold and Cough Relief Daytime", "Severe Cold and Cough Relief Daytime", "Severe Cold and Cough Relief Daytime", "Severe Cold and Cough Relief Daytime", "Severe Cold and Cough Relief Daytime", "Severe Cold and Cough Relief Daytime", "Severe Cold and Cough Relief Daytime", "Severe Cold and Flu", "Severe Cold and Flu", "Severe Cold and Flu", "Severe Cold and Flu", "Severe Cold and Flu", "Severe Cold and Flu", "Severe Cold and Flu", "Severe Cold and Flu", "Severe Cold and Flu", "Severe Cold and Flu", "Severe Cold and Flu", "Severe Cold and Flu", "Severe Cold and Flu", "Severe Cold and Flu", "Severe Cold and Flu", "Severe Cold and Flu", "Severe Cold and Flu", "Severe Cold and Flu", "Severe Cold and Flu", "Severe Cold and Flu", "Severe Cold and Flu", "Severe Cold and Flu", "Severe Cold and Flu Daytime", "SEVERE COLD AND FLU DAYTIME NON DROWSY and NIGHTTIME", "SEVERE COLD AND FLU DAYTIME NON DROWSY and NIGHTTIME", "SEVERE COLD AND FLU DAYTIME NON DROWSY and NIGHTTIME", "SEVERE COLD AND FLU DAYTIME NON DROWSY and NIGHTTIME", "Severe Cold and Flu Daytime Non Drowsy Nighttime", "Severe Cold and Flu Daytime Non Drowsy Nighttime", "Severe Cold and Flu Daytime Non Drowsy Nighttime", "Severe Cold and Flu Daytime Non Drowsy Nighttime", "Severe Cold and Flu Daytime Non Drowsy Nighttime", "Severe Cold and Flu Daytime Non Drowsy Nighttime", "Severe Cold and Flu Daytime Non Drowsy Nighttime", "Severe Cold and Flu Daytime Non Drowsy Nighttime", "Severe Cold and Flu Daytime/nighttime", "Severe Cold and Flu Daytime/nighttime", "Severe Cold and Flu Maximum Strength, Daytime, Non-Drowsy", "Severe Cold and Flu Night time", "Severe cold and flu Nighttime", "Severe Cold and Flu nighttime", "Severe cold and flu Nighttime", "Severe cold and flu Nighttime", "Severe cold and flu Nighttime", "Severe Cold and Flu Nighttime Daytime", "Severe Cold and Flu Nighttime Daytime", "Severe Cold and Flu Plus Congestion", "Severe Cold and Flu Plus Congestion", "Severe Cold and Flu Relief", "Severe Cold and Flu Relief", "Severe Cold and Flu Relief", "Severe Cold and Flu Relief", "Severe Cold and Flu Relief", "Severe Cold and Flu Relief", "Severe Cold and Flu Relief", "Severe Cold and Flu Relief Daytime", "Severe Cold and Flu Relief Daytime", "Severe Cold and Flu Relief Daytime", "Severe Cold and Flu Relief Daytime", "Severe Cold and Flu Relief Daytime", "Severe Cold and Flu Relief Daytime/Nighttime", "Severe Cold and Flu Relief Daytime/Nighttime", "Severe Cold and Flu Relief Daytime/Nighttime", "Severe Cold and Flu Relief Daytime/Nighttime", "Severe Cold and Flu Relief Nighttime", "Severe Cold and Mucus", "Severe Cold and Mucus", "Severe Cold Cough and Flu", "Severe Cold Cough and Flu Relief Daytime", "SEVERE COLD DAY COLD and FLU NIGHT", "Severe Cold Daytime", "Severe Cold Daytime", "Severe Cold Daytime", "Severe Cold Daytime Cold and Flu Nighttime", "Severe Cold Daytime Multi-Symptom Non-Drowsy", "Severe Cold DM", "Severe Cold DM Severe Cold and Flu", "Severe Cold Head Congestion", "Severe Cold Maximum Strength, Multi-Symptom", "Severe Cold Multi Symptom", "Severe Cold Multi Symptom", "Severe Cold Multi Symptom", "Severe Cold Multi-Symptom", "Severe Cold Plus Flu Daytime Nighttime", "Severe Cold Plus Flu Daytime Nighttime", "Severe Cold Relief", "Severe Cold, Cold and Flu Daytime, Nighttime, Maximum Strength", "severe cold, cold and flu Daytime/Nighttime", "Severe Cold, Cold and Flu Maximum Strength, Daytime, Nightime", "Severe Cold, Cold and Flu Maximum Strength, Daytime, Nightime", "Severe Congestion and Cold Maximum Strength", "Severe Congestion and Cold Maximum Strength/ Multi-Symptom", "Severe Congestion and Cold Relief Maximum Strength, Multi Symptom", "Severe Congestion and Cough", "Severe Congestion and Cough MAX Maxium Strength", "Severe Congestion and Cough Multi-Symptom Maximum Strength", "Severe Congestion and Cough Relief", "Severe Congestion and Cough Relief", "Severe Congestion and Cough Relief Maximum Strength", "Severe Congestion and Cough, Cold and Flu Daytime and Nighttime", "Severe Congestion and Cough, Cold and Flu Daytime, Nighttime", "Severe Congestion and Cough, Cold and Flu Daytime, Nighttime", "Severe Congestion and Cough, Cold and Flu Daytime, Nighttime", "Severe Congestion and Cough, Cold and Flu Daytime, Nighttime", "Severe Congestion and Cough/ Cold and Flu Daytime/nighttime", "Severe Congestion and Cough/Cold and Flu Daytime/Nighttime/Maximum Strength", "Severe Congestion Relief", "Severe Congestion, Cough, Cold and Flu Relief Maximum Strength, Nighttime", "Severe Congestion, Cough, Cold and Flu Relief Maximum Strength, Nighttime", "Severe Cough and Cold", "Severe Cough and Congestion", "Severe Cough and Congestion", "Severe Cough and Congestion", "Severe Cough and Congestion and Cold and Flu Daytime, Nighttime", "Severe Cough and Congestion Maximum Strength", "Severe Daytime", "Severe Daytime", "SEVERE DAYTIME COLD and FLU DAYTIME MAXIMUM STRENGTH NON-DROWSY SEVERE", "Severe DayTime NightTime Cold and Flu Relief Max Strength", "Severe DayTime NightTime Cold and Flu Relief Max Strength", "Severe Multi-Symptom Cold", "Severe Nighttime", "Severe Nighttime Cold and Flu", "Severe Nighttime Cold and Flu", "Severe Nighttime Cold and Flu", "Severe Nighttime Cold and Flu", "Severe Nighttime Cold and Flu", "Severe Nighttime Cold and Flu", "Severe Nighttime Cold and Flu", "Severe Nighttime Cold and Flu", "Severe Nighttime Cold and Flu Relief", "Severe Nighttime Severe Daytime", "Severe Nighttime Severe Daytime", "Severe Sinus Congestion", "Severe Sinus Congestion", "Severe Sinus Congestion Allergy and Cough Formula", "Severe Sinus Congestion Allergy and Cough Formula", "Severe Sinus Congestion and Cough Daytime Non-drowsy / Nightime", "Severe Sinus Congestion and Cough Daytime Non-drowsy / Nightime", "Severe sinus Congestion Relief", "Severe sinus Congestion Relief", "Severe sinus Congestion Relief", "Severe sinus Congestion Relief", "Severe sinus Congestion Relief", "Severe sinus Congestion Relief", "Severe Tussin CF", "Severe Tussin CF", "Severe Vapor Ice Cold and Flu Relief", "Severe Wal Tussin CF Max", "shop rite Day Severe Cold Night Cold and Flu", "shop rite Day Severe Cold Night Cold and Flu", "Shopko Chest Congestion Relief DMTDM TDM", "ShopRite Adult Tussin", "ShopRite Adult Tussin", "Shoprite Adult Tussin", "ShopRite Adult Tussin", "ShopRite Childrens Cold and Cough", "ShopRite Childrens Multi Symptom Cold Relief", "ShopRite Cold Multi Symptom", "ShopRite Cough DM", "ShopRite Day Calm", "ShopRite Day Calm", "Shoprite Day Calm Severe", "ShopRite Day Calm Severe", "ShopRite DayTime Flu Plus Severe Cold And Cough", "ShopRite Ni Calm", "ShopRite Ni Calm", "ShopRite Ni Calm", "ShopRite Ni Calm", "Shoprite Ni Calm", "ShopRite Ni Calm Cough", "ShopRite Severe Cold", "Signature Care 12 Hour Cough Relief", "Signature Care Childrens 12 Hour Cough Relief", "Signature Care Childrens Cold and Cough", "Signature Care Childrens Multi Symptom Cold", "Signature Care Cough DM", "Signature Care Cough Relief", "Signature Care Daytime Cough", "Signature Care daytime nighttime severe cold and flu relief", "Signature Care daytime nighttime severe cold and flu relief", "Signature Care Daytime Severe Cold", "Signature Care Daytime Severe Cold and Flu Relief", "Signature Care Mucus Relief DM", "Signature Care Nighttime Severe Cold and Flu Relief", "Signature Care Nighttime Severe Cold and Flu Relief", "Signature Care Non drowsy Daytime Severe Cold and Flu Relief", "Signature Care Tussin", "Signature Care Tussin", "Sildec DM", "Sildec PE DM", "Sildec PE DM", "Sildec PE DM", "Silphen DM Cough", "Siltussin DM", "Siltussin DM", "Siltussin DM", "Siltussin DM", "Siltussin DM DAS Cough Formula", "Siltussin DM DAS Cough Formula", "Siltussin DM DAS Cough Formula", "Simply Right Night Time", "simply right Night Time", "Simuc DM", "Sinex Severe plus Vicks VapoCool", "Sinex Severe plus Vicks VapoCool", "Sinus Max Relief Day and Night", "Sinus Max Relief Day and Night", "Sinus PE Head Congestion and Flu Severe", "Sinus PE Pressure, Pain and Cold Daytime, Non-Drowsy", "Sinus PE Pressure, Pain plus Cough Multi-Symptom", "Sinus Pressure and Pain and Cough", "Sinus Pressure Pain and Cough", "Sinus Pressure, Pain and Cough", "Sinus Pressure, Pain and Cough", "Sinus Relief Maximum Strength", "Sinus Relief Pressure, Pain and Cough", "Sirop DM", "Sirop DM Expectorant", "Smart Sense Adult Tussin DM sugar free", "Smart Sense Adults Tussin CF Multi Symptom Cold", "Smart Sense Childrens Multi Symptom Cold Relief", "Smart Sense Cold and Cough", "Smart Sense cold flu and sore throat", "Smart Sense Cough and Chest Congestion", "Smart Sense Cough and Chest Congestion", "Smart Sense Cough and chest congestion", "Smart Sense Cough DM", "Smart Sense Cough DM", "Smart Sense DayTime", "Smart Sense Daytime", "Smart Sense daytime cold and flu", "Smart Sense Daytime Nighttime Cold and Flu", "Smart Sense Daytime Nighttime Cold and Flu", "Smart Sense Daytime Nighttime Cold and Flu", "Smart Sense Daytime Nighttime Cold and Flu", "Smart Sense Flu and Severe Cold and Cough Daytime", "Smart Sense Mucus Relief Cough Childrens", "Smart Sense Multi Symptom Cold", "Smart Sense Multi Symptom Cold", "Smart Sense Multi Symptom Fever and Cold Childrens", "Smart Sense Nighttime", "Smart Sense Nighttime", "Smart Sense Nighttime", "Smart Sense Nighttime", "Smart Sense NightTime Cold and Flu", "Smart Sense nighttime cold and flu", "Smart Sense Nighttime Cold and Flu Relief Multi Symptom", "Smart Sense Nighttime Cough", "Smart Sense NightTime DayTime", "Smart Sense NightTime DayTime", "Smart Sense Severe Cold", "Smart Sense Severe Cold and Flu NightTime", "Smart Sense Tussin CF Adult", "Smart Sense Tussin DM", "Smart Sense tussin dm max adult", "SMITH BROS NIGHT TIME COUGH and CONGESTION", "SMITH BROS NON-DROWSY DAY TIME COLD and FLU", "SMITH BROS NON-DROWSY MULTI-SYMPTOM COLD and FLU", "SoCheongRyong Tang Extract", "SohMed Cold Relief", "Sonahist DM", "Soothe Comfort I Cough Syrup Original", "Soothe Comfort I Cough Syrup Original", "Soothe Comfort II Cough Syrup Herbal Mint", "Soothe Comfort II Cough Syrup Herbal Mint", "Sorbugen", "Sorbutuss NR", "Sore Throat & Cough Ultra Strength", "Sore Throat and Cough", "Sore throat and cough lozenge", "Sore Throat and Cough Lozenge", "Sound Body Cold and Flu Relief", "Sound Body Cold and Flu Relief", "Sound Body Cold and Flu Relief", "Sound Body Cold and Flu Relief", "Sound Body Cold and Flu Relief DayTime", "Sound Body Daytime Cold and Flu Relief Nighttime Cold and Flu Relief", "Sound Body Daytime Cold and Flu Relief Nighttime Cold and Flu Relief", "Sound Body Mucus DM", "Sound Body Severe Cold and Flu", "Sound Body Tussin CF", "Sound Body Tussin DM", "Sound Body Tussin DM", "Stona", "Stona", "Stona Cough", "Stona Cough", "Stona for Children", "Stona-S", "Stop Cough PLUS", "Sucrets Cough Cherry", "Sucrets Cough Control", "Sucrets Cough Control Lozenges", "Sucrets Cough Honey Lemon", "Sucrets DM Cough Suppressant-honey Lemon", "Sudafed Cold and Cough Extra Strength Caplet", "Sudafed Cold and Cough Extra Strength Caplets", "Sudafed Cold and Flu Gel Caps", "Sudafed DM", "Sudafed PE Cold and Flu Caplets", "SUDAFED PE Head Congestion Plus Flu Severe", "Sudafed PE Pressure Plus Pain Plus Cold", "Sudafed PE Pressure plus Pain plus Cough", "Sudafed PE Pressure Plus Pain Plus Cough Day", "Sudafed PE Total", "Sudafed Total Cold and Flu Rapid Release", "Sudatex - DM", "Sudatex - DM", "Sugar Free Cough and Chest Congestion Relief Adult", "Sun Mark Mucus Relief Cough Childrens", "Sun Mark Tussin DM cough and chest congestion", "Sun Mark Tussin DM cough and chest congestion", "Sun Mark Tussin DM cough and chest congestion", "Sunmark Adult Tussin DM", "Sunmark Adult Tussin DM", "Sunmark Chest Congestion Relief DM DM", "sunmark Cold", "Sunmark Cold and Cough DM Childrens", "Sunmark Cold and Flu Severe", "Sunmark Cold Head Congestion", "Sunmark cold head congestion", "Sunmark cough dm", "Sunmark cough dm", "Sunmark Day Time Cold and Cough Childrens Triacting Formula", "Sunmark Day time cold and flu", "Sunmark mucus relief DM", "Sunmark Nite Time", "Sunmark Nite Time", "Sunmark nite time cold and flu", "Sunmark Nite Time Cough", "Sunmark Nite Time D Cold and Flu", "Sunmark Severe Day Time", "Sunmark Severe Nite Time Cold and Flu", "Sunmark Tussin CF", "Sunmark Tussin DM Max", "Sunmark Tussin DM Sugar Free", "Supress A", "Supress DM", "Supress DX Pediatric Drops", "Syrup DM - 15mg/5ml", "Syrup DM-D", "Syrup DM-D-E", "Syrup DM-E", "Tabcin Extra Strength", "Tantacol DM Syr", "Target Cold/Flu Relief", "Target Cough plus Chest Congestion DM Max with Honey", "Target Maximum Strength Cold Flu and Sore Throat", "Target Maximum Strength Cold Flu and Sore Throat Overnight Cold and Flu", "Target Maximum Strength Cold Flu and Sore Throat Overnight Cold and Flu", "Target Overnight Cold and Flu", "Tenalif Children", "Tenalif Multi Symptom Relief", "Texaclear Daytime Cough Cold/flu", "TexaClear Kids Cough and Cold", "Theraflu Cough Relief", "Theraflu Daytime Severe Cold and Cough", "Theraflu Daytime Severe Cold and Cough", "Theraflu Daytime Severe Cold and Cough", "Theraflu ExpressMax Daytime Nighttime Value Pack", "Theraflu ExpressMax Daytime Severe Cold and Cough", "Theraflu ExpressMax Daytime Severe Cold and Cough", "Theraflu Expressmax Daytime Severe Cold and Cough and Theraflu Expressmax Nighttime Severe Cold and Cough", "Theraflu ExpressMax Severe Cold and Flu Caplets", "Theraflu ExpressMax Severe Cold and Flu Syrup", "Theraflu Flu Cold and Cough Medicine", "Theraflu Flu Relief Max Strength Daytime", "Theraflu Flu Relief Max Strength Daytime Nighttime Combo Pack", "Theraflu Flu Relief Max Strength Daytime Nighttime Combo Pack", "Theraflu Flu Relief Max Strength Daytime Nighttime Value Pack", "Theraflu Flu Relief Max Strength Daytime Nighttime Value Pack", "Theraflu Flu Relief Max Strength Nighttime", "Theraflu Flu Relief Maximum Strength Daytime Nighttime Combo Pack", "Theraflu Flu Relief Maximum Strength Daytime Nighttime Combo Pack", "Theraflu Max-D", "Theraflu Multi-symptom Severe Cold", "Theraflu Multi-Symptom Severe Cold and Theraflu Nighttime Severe Cold and Cough", "Theraflu Multi-Symptom Severe Cold and Theraflu Nighttime Severe Cold and Cough", "Theraflu PowerPods Daytime Severe Cold", "Theraflu Relief Max Strength Daytime", "Theraflu Relief Max Strength Nighttime", "Theraflu Severe Cold Relief Daytime and Theraflu Severe Cold Relief Nighttime", "Theraflu Severe Cold Relief Daytime with Honey Ginger Flavor", "Theraflu Severe Cold relief Nighttime", "Theraflu Warming Relief Daytime Multi-Symptom Cold Caplets", "Theraflu Warming Relief Daytime Severe Cold And Cough", "Theraflu Warming Relief Nighttime Multi-Symptom Cold Caplets", "Thompson Cough and Cold Multi-Symptom Relief", "Tickly Throat Cough Syrup", "Tl-hist DM", "Tl-hist DM", "Toa Syrup Adult", "Top Care Day Time Multi Symptom Relief", "TopCare Chest Congestion and Cough Relief DM", "Topcare childrens cold and cough", "Topcare Childrens Cold and Flu", "Topcare childrens cold cough and sore throat", "Topcare Childrens Mucus Relief Multi Symptom Cold", "Topcare Cold", "Topcare Cold", "Topcare Cold", "Topcare Cold and Cough", "Topcare Cold and Cough", "Topcare Cold and Cough", "Topcare Cold and Flu", "Topcare Cold and Flu", "Topcare Cold and Flu", "Topcare Cold Head Congestion", "Topcare Cold Head Congestion Nighttime", "Topcare Cold Head Congestion Severe", "TopCare Cold Max", "Topcare Cold Multi Symptom", "Topcare Cold Multi Symptom Severe", "TopCare Cold NightTime Multi Symptom", "Topcare Cough and Sore Throat", "Topcare Cough and Sore Throat", "Topcare Cough Cold and Flu Simple Relief", "Topcare Cough DM", "TopCare Cough DM", "TopCare Cough DM", "TopCare Cough DM", "TopCare Cough Relief Honey Lemon Flavor", "TopCare Cough Relief Sugar Free Cherry Flavor", "Topcare Day Night", "Topcare Day Night", "Topcare Day Time", "Topcare Day Time Cold and Flu", "Topcare Day Time Cold and Flu", "Topcare Day Time Cold and Flu", "Topcare Day Time Cold and Flu", "Topcare Day Time Cold and Flu", "Topcare Day time cold and flu relief", "Topcare Day Time Cold and Flu Relief Multi Symptom Relief", "Topcare Day Time Cold and Flu Severe", "TopCare Day Time Cough", "Topcare Day Time Nite Time", "Topcare Day Time Nite Time", "Topcare Day Time Nite Time", "Topcare Day Time Nite Time", "Topcare Day Time Nite Time Cold and Flu", "Topcare Day Time Nite Time Cold and Flu", "Topcare Day Time Nite Time Cold and Flu", "Topcare Day Time Nite Time Cold and Flu", "Topcare Day Time Nite Time Cold and Flu", "Topcare Day Time Nite Time Cold and Flu", "Topcare Day Time Nite Time Cold and Flu", "Topcare Day Time Nite Time Cold and Flu", "Topcare Day Time Nite Time Cold and Flu Relief", "Topcare Day Time Nite Time Cold and Flu Relief", "TopCare Day Time Nite Time Cold and Flu Relief", "TopCare Day Time Nite Time Cold and Flu Relief", "Topcare Day Time Nite Time Cold and Flu Relief", "Topcare Day Time Nite Time Cold and Flu Relief", "TopCare day time severe cold and cough berry infused with menthol and green tea flavors", "Topcare DayTime", "Topcare Daytime Nitetime Multi Symptom Relief", "Topcare Daytime Nitetime Multi Symptom Relief", "TopCare Daytime Severe Cold and Cough Berry infused with Menthol and Green Tea flavors", "Topcare Flu and Severe Cold and Cough Daytime", "TopCare Health Non Drowsy Daytime Cold and Flu Relief And Nighttime Cold and Flu Relief Day and Night Combo Pack", "TopCare Health Non Drowsy Daytime Cold and Flu Relief And Nighttime Cold and Flu Relief Day and Night Combo Pack", "Topcare Mucus DM", "Topcare Mucus DM", "TopCare Mucus DM", "Topcare Mucus Relief", "Topcare mucus relief", "Topcare Mucus Relief", "TopCare Mucus Relief and Cold and Flu", "Topcare Mucus Relief Cold and Flu", "Topcare mucus relief cold flu and sore throat", "Topcare Mucus Relief Cold Flu and Sore Throat", "Topcare Mucus Relief Severe Congestion and Cold", "TopCare Multi Symptom Severe Cold", "TopCare Nite Time", "TopCare Nite Time Cold and flu", "Topcare Nite Time Cold and Flu", "Topcare Nite Time Cold and Flu", "Topcare Nite Time Cold and Flu", "Topcare Nite Time Cold and Flu", "Topcare Nite Time Cold and Flu", "Topcare Nite Time Cold and Flu", "Topcare Nite Time Cold and Flu", "Topcare Nite Time Cold and Flu", "Topcare Nite Time Cold and Flu", "Topcare Nite Time Cold and Flu Relief", "Topcare Nite Time Cold and Flu Relief", "Topcare Nite Time Cold and flu relief", "Topcare Nite Time Cold and Flu Relief Multi Symptom Relief", "Topcare Nite Time Cough", "Topcare Nite Time D", "Topcare Nite Time Day Time Cold and Flu", "Topcare Nite Time Day Time Cold and Flu", "Topcare Nite Time Day Time Cold and Flu Relief", "Topcare Nite Time Day Time Cold and Flu Relief", "Topcare Nite Time Multi Symptom Relief", "TopCare Pain Relief Cold Nightttime", "Topcare Severe Sinus Congestion", "TopCare Tab Tussin DM", "topcare tussin CF", "Topcare Tussin CF Max", "Topcare Tussin CF Max", "Topcare Tussin Cough Long Acting", "Topcare Tussin DM", "Topcare Tussin DM", "Topcare Tussin DM Max", "Topcare Tussin DM Max", "Topcare Tussin DM Max", "Topcare Tussin DM Max", "TopCare Tussin DM Nighttime Cough", "Topcare tussin dm sugar free cough and chest congestion", "Topco tussin cf max", "Total Cold", "Total Cold & Flu", "Total Cold & Flu Combo", "Total Cold & Flu Extra Strength Night", "Total Cold and Flu", "Total Cold and Flu", "Total Cold and Flu Extra Strength", "Total Cough, Cold & Flu Ultra Strength", "Total Flu", "Total Flu Ultra Strength", "Toux Rhume Et Grippe (extra-fort)", "Tri-dex PE", "Triacting Cough and Sore Throat Grape", "Triacting Day Time Cold and Cough Childrens", "Triacting Day Time Cold and Cough Childrens", "Triacting Day Time with PE", "Triacting Day Time with PE", "Triacting Daytime Cold Cough Childrens", "Triacting Daytime Cold Cough Childrens", "Triacting Daytime Cold Cough Childrens", "Triacting Daytime Cold Cough Childrens", "Triacting Daytime Cold Cough Childrens", "Trialyn Syrup", "Triaminic Cold & Nighttime Cough", "Triaminic Cold and Cough", "Triaminic Cold Cough and Fever", "Triaminic Cough", "Triaminic Cough and Congestion", "Triaminic Cough and Congestion", "Triaminic Cough and Sore Throat", "Triaminic cough and sore throat", "Triaminic Cough and Sore Throat", "Triaminic Cough and Sore Throat Softchews", "Triaminic Day - Night Club Pack", "Triaminic Day Time Cold and Cough", "Triaminic Day Time Cold and Cough", "Triaminic Day Time Cold and Cough and Night Time Cold and Cough", "Triaminic Daytime Cough & Cold", "Triaminic DM", "Triaminic DM - Syrup - 15 Mg/5 Ml", "Triaminic DM Daytime Syr", "Triaminic DM Expectorant Syr", "Triaminic DM Plus Decongestant Syrup", "Triaminic DM+decongestant Liqui-gels Capsules", "Triaminic Fever & Cough", "Triaminic Long Acting Cough", "Triaminic Long Acting Cough", "Triaminic Multi-Symptom Fever", "Triaminic Multi-Symptom Fever and Cold", "Triaminic Softchews Cough", "Triaminic Softchews Cough and Cold", "Triaminic Softchews Throat Pain & Cough", "Triaminic Thin Strips Cold & Cough", "Triaminic Thin Strips Cough", "Triaminic Toddler Cough and Cold Thin Strips", "Triaminic Total Cold With Cough & Fever Relief", "Triaminicol DM Syrup", "Trigofen DM", "Triplex DM", "Triponel", "Triponel", "TRISPEC DMX Cough Suppressant Expectorant Peach Flavor", "TRISPEC DMX Pediatric Drops Cough Suppressant Expectorant CHERRY RASPBERRY Flavor", "TRISPEC PSE Cough Suppressant Expectorant Nasal Decongestant GRAPE Flavor", "TRISPEC PSE Pediatric Drops Cough Suppressant Expectorant Nasal Decongestant GRAPE Flavor", "Trital DM", "Tukol A", "Tukol Children Cough and Congestion", "Tukol Childrens Cold and Flu", "Tukol Cough And Cold Honey Flavor", "Tukol Cough and Congestion", "Tukol Cough and Congestion", "Tukol Day Time Cold and Flu Relief Softgels", "Tukol For Diabetics", "Tukol Honey Children Cough and Congestion", "Tukol Honey Daytime and Nighttime Value Pack", "Tukol Honey Daytime and Nighttime Value Pack", "Tukol Honey Daytime Cold and Flu", "Tukol Honey Nighttime Cold and Flu", "Tukol Max Action Cold Sore Throat and Cough", "Tukol Max Action Cold, Flu and Sore Throat", "Tukol MAX ACTION Cold, Sore Throat and Cough", "Tukol Max Action DM Max", "Tukol MAX ACTION Severe Congestion and Cough", "Tukol Max Action Severe Congestion and Cough", "Tukol Maxium Strength Cough and Mucus Relief", "Tukol Multi Symptom Cold", "Tukol Night Time Cold and Flu Relief Softgels", "Tukol X-Pecto Miel Multi Symptom Cold", "Tusdec DM", "Tusicof", "Tusicof", "Tusnel", "Tusnel", "Tusnel Cough Suppressant Expectorant", "Tusnel Diabetic", "Tusnel DM", "Tusnel DM Pediatric", "Tusnel Pediatric", "Tusnel Pediatric DM", "Tusnel SF", "Tusnel-DM Pediatric", "Tussi Pres", "Tussi Pres", "Tussi Pres B", "Tussi Pres Pediatric", "Tussilyn DM", "Tussin", "Tussin", "Tussin", "Tussin", "Tussin", "Tussin", "Tussin 12 HR", "Tussin 12 HR", "Tussin Adult", "Tussin CF", "Tussin CF", "Tussin CF", "Tussin CF", "Tussin CF", "Tussin CF", "Tussin CF", "Tussin CF", "Tussin CF", "Tussin CF", "Tussin CF", "Tussin CF", "Tussin CF", "Tussin CF", "Tussin CF", "Tussin CF", "Tussin CF", "Tussin CF", "Tussin CF", "Tussin CF Adult", "Tussin CF Adult Cough and Cold", "Tussin CF Adult Maximum Strength", "Tussin CF Adult Multi Symptom Cold", "Tussin CF Adult Non Drowsy", "Tussin CF Cough and Cold", "Tussin CF Dextromethorphan HBr, Guaifenesin, Phenylephrine HCL", "Tussin CF Max", "Tussin CF Max", "Tussin CF Max", "Tussin CF Maximum Strength", "Tussin CF Maximum Strength", "Tussin CF Maximum Strength", "Tussin CF Multi Symptom Cold Adult", "Tussin CF Multi-Symptom Cold", "Tussin CF Non Drowsy", "Tussin CF Non Drowsy", "Tussin CF Non Drowsy Multi Symptom", "Tussin CF Non Drowsy Multi Symptom", "Tussin Cough", "Tussin Cough Adult Maximum Strength", "Tussin cough and chest congestion", "Tussin Cough and Chest Congestion", "Tussin Cough and Chest Congestion DM", "Tussin Cough and Chest Congestion DM", "tussin cough and chest congestion DM", "Tussin Cough and Chest Congestion DM Adult", "Tussin Cough and Chest Congestion DM Adult", "Tussin Cough and Chest Congestion DM Adult", "Tussin Cough and Chest Congestion DM adult", "Tussin Cough and Chest Congestion DM adult", "Tussin Cough and Chest Congestion DM Max", "Tussin Cough and Chest Congestion DM maximum strength", "Tussin Cough and Chest Congestion DM Sugar Free", "Tussin Cough and Chest Congestion DM Sugar Free", "Tussin Cough and Chest Congestion DM Sugar Free", "Tussin Cough Chest Congestion", "Tussin Cough DM Adult", "Tussin Cough DM Adult Sugar Free", "Tussin Cough DM Sugar Free", "Tussin Cough DM Sugar Free", "Tussin Cough DM Sugar Free", "Tussin Cough Expectorant Cough Supressant DM", "Tussin Cough Expectorant Cough Supressant DM", "Tussin Cough Gels", "Tussin Cough Gels", "Tussin Cough Gels", "Tussin Cough Gels", "Tussin Cough Gels", "Tussin Cough Long Acting", "Tussin Cough Long Acting", "Tussin Cough Long Acting", "Tussin Cough Long Acting", "Tussin Cough Long Acting", "Tussin Cough Long Acting", "Tussin Cough Long Acting", "Tussin Cough Long Acting", "Tussin Cough Long Acting", "Tussin Cough Medicine DM Antitussive", "Tussin Cough Medicine DM Antitussive Expectorant Decongestant", "Tussin Cough Non-Drowsy", "Tussin Cough Non-Drowsy Liquidgels", "Tussin DM", "Tussin DM", "Tussin DM", "Tussin DM", "Tussin DM", "Tussin DM", "Tussin DM", "Tussin DM", "Tussin DM", "Tussin DM", "Tussin DM", "Tussin DM", "Tussin DM", "Tussin DM", "Tussin DM", "Tussin DM", "Tussin DM", "Tussin DM", "Tussin DM", "Tussin DM", "Tussin DM", "Tussin DM", "Tussin DM", "Tussin DM", "Tussin DM", "Tussin DM", "Tussin DM Adult", "Tussin DM Adult", "Tussin DM Adult", "Tussin DM adult cough and chest congestion", "Tussin DM Adult cough and chest congestion", "Tussin DM Adults", "Tussin DM Cough and Chest Congestion", "Tussin DM cough and chest congestion", "Tussin DM Cough and Chest Congestion", "Tussin DM Cough and Chest Congestion", "Tussin DM Cough and Chest Congestion", "Tussin DM Cough and Chest Congestion", "Tussin DM Cough and Chest Congestion", "Tussin DM Cough and Chest Congestion", "Tussin DM cough and chest congestion", "Tussin DM Cough and Chest Congestion Adult", "Tussin DM Cough and Chest Congestion Non Drowsy", "Tussin DM Cough and Chest Congestion sugar-free ReadyInCase", "Tussin DM Cough and Chest Non Drowsy", "Tussin DM Cough Nighttime Maximum Strength", "Tussin DM COUGH SUPPRESSANT/EXPECTORANT", "Tussin DM COUGH SUPPRESSANT/EXPECTORANT", "Tussin DM Daytime", "Tussin DM Daytime Nighttime", "Tussin DM Daytime Nighttime", "Tussin DM Max", "Tussin DM Max", "Tussin DM Max", "Tussin DM Max", "Tussin DM Max Adult Cough and Chest Congestion", "Tussin DM Max Adult Cough Plus Chest Congestion", "Tussin DM Max Cough and Chest Congestion", "Tussin DM Max Daytime Nighttime", "Tussin DM Max Daytime Nighttime", "Tussin DM Max Nighttime", "Tussin DM Max non drowsy", "Tussin DM Maximum Strength", "Tussin DM Nighttime", "Tussin DM Nighttime Cough Maximum Strength", "Tussin DM Sugar Free", "Tussin DM Sugar Free Non Drowsy", "Tussin DMMax", "Tussin DMMaximum Strength", "Tussin Long Acting Cough", "Tussin Long Acting Cough", "Tussin Long Acting Cough READYINCASE", "Tussin Maximum Strength", "Tussin Multi Symptom", "Tussin Multi Symptom Cold CF", "Tussin Multi Symptom Cold CF", "Tussin Multi Symptom Cold CF Adult", "Tussin Multi Symptom Cold CF Adult", "Tussin Multi Symptom Cold CF Adult", "Tussin Multi Symptom Cold CF Adult", "Tussin Multi Symptom Cold CF Adult", "Tussin Multi Symptom Cold CF Adult", "Tussin Multi Symptom Cold CF Adult", "Tussin Nighttime Cough", "Tussin Nighttime Cough Control", "Tussin Nighttime Cough DM Maximum Strength", "Tussin Nighttime Cough DM Maximum Strength", "Tussin Peak Cold Cough plus Chest Congestion DM", "Tussin Peak Cold Maximum Strength Cough plus Chest Congestion DM", "Tussin Peak Cold sugar-free COUGH PLUS CHEST CONGESTION DM", "Tussin Severe", "Tussin Severe Cough Cold Flu", "tussin severe multi symptom cough cold plus flu CF MAX", "Tussin Sugar Free", "Tussin Sugar Free Cough", "Tussin Sugar Free Cough", "Tussin Sugar Free Cough", "Tussin Sugar Free Cough", "Tussin Sugar Free Cough", "Tussin Sugar Free Cough", "Tussin Sugar Free Cough", "Tusslin", "Tusslin Pediatric", "Tusslin TR", "Tussnex FM Cold, Flu and Sore Throat", "Tussnex FM Severe cough and congestion", "Tussodan DM Syrup", "Twkof Adult", "Twkof Children", "Tylenol Cold & Flu Daytime", "Tylenol Cold & Flu Nighttime", "Tylenol Cold and Flu", "Tylenol Cold and Flu Daytime", "Tylenol Cold and Flu Nighttime", "TYLENOL COLD Cough and Severe Congestion", "Tylenol Cold Head Congestion Severe", "Tylenol Cold Head Congestion Severe", "TYLENOL Cold Max Day", "Tylenol Cold Max Day", "Tylenol Cold Max Night", "Tylenol Cold Multi-Symptom", "TYLENOL COLD Multi-Symptom", "Tylenol Cold Multi-symptom", "TYLENOL Cold Multi-Symptom Daytime", "Tylenol Cold Multi-symptom Daytime", "TYLENOL Cold Multi-Symptom Severe", "Tylenol Cold Nightime Rapid Release", "TYLENOL Cold plus Flu plus Cough Day", "Tylenol Cold plus Flu plus Cough Night", "Tylenol Cold Plus Flu Severe", "Tylenol Cold Plus Flu Severe", "TYLENOL Cold Plus Flu Severe", "Tylenol Cold Plus Flu Severe", "Tylenol Cold Plus Flu Severe", "Tylenol Cold Plus Flu Severe", "Tylenol Cold Plus Flu Severe", "Tylenol Cold Plus Flu Severe", "Tylenol Cold Plus Flu Severe", "Tylenol Cold Plus Flu Severe", "Tylenol Cold plus Flu Severe and Tylenol Cold Max", "Tylenol Cold plus Flu Severe and Tylenol Cold Max", "TYLENOL Cold Plus Flu Severe and TYLENOL COLD MAX CoPack", "TYLENOL Cold Plus Flu Severe and TYLENOL COLD MAX CoPack", "Tylenol Cold Plus Flu Severe Day and Tylenol Cold Plus Flu Plus Cough Night 2-pack", "Tylenol Cold Plus Flu Severe Day and Tylenol Cold Plus Flu Plus Cough Night 2-pack", "Tylenol Cold Plus Flu Severe Day and Tylenol Cold Plus Flu Plus Cough Night 3-Pack", "Tylenol Cold Plus Flu Severe Day and Tylenol Cold Plus Flu Plus Cough Night 3-Pack", "Tylenol Cold Plus Flu Severe Day/night", "Tylenol Cold Plus Flu Severe Day/night", "Tylenol Cold Plus Flu Severe Severe", "TYLENOL Cold Plus Mucus Severe", "Tylenol Cold Rapid Release", "Tylenol Complete Cold, Cough & Flu Daytime", "Tylenol Complete Cold, Cough & Flu Nighttime", "Tylenol Complete Cold, Cough & Flu Plus Mucus Relief", "Tylenol Cough", "TYLENOL COUGH and SORE THROAT", "Tylenol Fever & Cough", "Tylenol Flu Daytime", "Tylenol Flu Nighttime", "Tylo Cold and Flu Day", "Tylo Cold and Flu Night", "Ultra Strength Neocitran Flu Day With Mucus Relief", "Ultra Tuss DM", "Ultra Tuss Safe", "Unishield Cold Relief", "Unishield Cough and Cold", "Up and Up 12 Hour Cough Relief", "Up and Up Adult Cough and Cold", "Up and Up Adult Cough Formula DM Max", "Up and Up adult cough formula DM Non drowsy", "Up and Up Childrens Cold and Cough", "Up and Up Childrens Mucus Relief and Cough", "Up and Up Childrens Multi Symptom Cold Pain Relief Plus", "Up and Up Cold and Flu Relief", "Up and Up Cold and Flu Relief", "Up and Up Cold and Flu Relief", "Up and Up Cold and Flu Relief Multi Symptom Day and Night Combo Pack", "Up and Up Cold and Flu Relief Multi Symptom Day and Night Combo Pack", "Up and Up Cold and Head Congestion", "Up and Up Cold Flu Relief", "Up and Up Cold Flu Relief", "Up and Up Cold Flu Relief", "Up and Up Cold Flu Relief", "Up and Up Cold Flu Relief", "Up and Up Cold Flu Relief Day Night", "Up and Up Cold Flu Relief Day Night", "Up and Up Cold Flu Relief Multi Symptom Day", "Up and Up Cold Flu Relief multi symptom night", "Up and Up Cold Relief", "Up and Up Cold Relief", "Up and Up Cough Plus Chest Congestion", "Up and Up Cough Suppressant DM", "Up and Up Cough Suppressant DM", "Up and Up Daytime Cold and Flu", "Up and Up Daytime Multi Symptom Severe Cold Nighttime Severe Cold and Cough", "Up and Up Daytime Nighttime Cold and Flu", "Up and Up Daytime Nighttime Cold and Flu", "Up and Up Daytime Nighttime Cold and Flu", "Up and Up Daytime Nighttime Cold and Flu", "Up and Up Daytime Severe Cold Nighttime Cold and Flu", "Up and Up Daytime Vapor Ice Cold and Flu Nighttime Vapor Ice Cold and Flu", "Up and Up Daytime Vapor Ice Cold and Flu Nighttime Vapor Ice Cold and Flu", "Up and Up Daytime Vapor Ice Cold and Flu Nighttime Vapor Ice Cold and Flu", "Up and Up Daytime Vapor Ice Cold and Flu Nighttime Vapor Ice Cold and Flu", "Up and Up DM Max Cough Plus Chest Congestion", "Up and Up Fast Mucus Relief Severe Cold", "Up and Up Flu and Severe Cold and Cough Relief", "Up and Up maximum Strength fast mucus relief Severe Congestion and Cough", "Up and Up Maximum Strength Mucus Relief DM", "Up and Up Mucus Relief", "Up and Up Mucus Relief Cold Flu and Sore Throat", "Up and Up mucus relief cold, flu and sore throat", "Up and Up Mucus Relief DM", "Up and Up Mucus Relief DM", "Up and Up Mucus Relief Severe Congestion and Cold", "Up and Up mucus relief severe congestion and cough", "Up and Up Nighttime Cold and Flu", "Up and Up Nighttime Cold and Flu", "Up and Up Nighttime Cold and Flu", "Up and Up Nighttime Cold and Flu", "Up and Up nighttime cough control", "Up and Up Nighttime Cough Control DM Max", "Up and Up Nighttime Daytime Cold and Flu", "Up and Up Nighttime Daytime Cold and Flu", "Up and Up Nighttime Severe Cold and Flu", "Up and Up Nighttime Severe Cold and Flu", "Up and Up Nighttime Vapor Ice Cold and Flu", "Up and Up severe cold and flu", "Up and Up severe cold and flu", "Up and Up severe cold and flu daytime", "Up and Up Tussin Multi Symptom Cold Maximum Strength", "Vanacof DM", "Vanacof DMX", "VanaTab DM", "Vapor Chill Cold and Flu Daytime/nighttime", "Vapor Chill Cold and Flu Daytime/nighttime", "Vapor Ice Daytime and Nitetime Cold and Flu", "Vapor Ice Daytime and Nitetime Cold and Flu", "Vasofrinic Plus Sirop", "Vicks 44 Cough Relief", "Vicks 44 D", "Vicks 44 E Cough and Chest Congestion Relief", "Vicks 44 M", "Vicks Alcohol Free NyQuil Cold and Flu Nighttime Relief", "Vicks Children's Nyquil Cold & Cough Multi-symptom Relief", "Vicks Childrens Cold Multi Symptom", "Vicks childrens Cough Congestion", "Vicks childrens Cough Congestion", "Vicks Childrens Cough Congestion", "Vicks Childrens NyQuil Cold and Cough Multi-Symptom Relief", "Vicks Childrens NyQuil Cold and Cough Multi-Symptom Relief", "Vicks Cough and Cold Severe", "Vicks Cough and Congestion DM", "Vicks Custom Care Chest Congestion/cough", "Vicks Custom Care Cough & Cold PM", "Vicks Custom Care Dry Cough", "Vicks Custom Care Nasal Congestion/cough", "Vicks DayQuil and Nyquil VapoCOOL Severe COLD and FLU plus CONGESTION", "Vicks DayQuil and Nyquil VapoCOOL Severe COLD and FLU plus CONGESTION", "Vicks DayQuil and Vicks NyQuil Cherry Cold and Flu", "Vicks DayQuil and Vicks NyQuil Cherry Cold and Flu", "Vicks DayQuil and Vicks NyQuil Cold and Flu", "Vicks DayQuil and Vicks NyQuil Cold and Flu", "Vicks DayQuil and Vicks NyQuil COLD and FLU", "Vicks DayQuil and Vicks NyQuil COLD and FLU", "Vicks DayQuil and Vicks NyQuil Cold and Flu", "Vicks DayQuil and Vicks NyQuil Cold and Flu", "Vicks DayQuil and Vicks NyQuil Cold and Flu Multi-Symptom Relief/Cold and Flu Nighttime Relief", "Vicks DayQuil and Vicks NyQuil Cold and Flu Multi-Symptom Relief/Cold and Flu Nighttime Relief", "Vicks DayQuil and Vicks NyQuil Cold and Flu Multi-Symptom Relief/Cold and Flu Nighttime Relief", "Vicks DayQuil and Vicks NyQuil Cold and Flu Multi-Symptom Relief/Cold and Flu Nighttime Relief", "Vicks DayQuil and Vicks NyQuil Cold and Flu Multi-Symptom Relief/Cold and Flu Nighttime Relief", "Vicks DayQuil and Vicks NyQuil Cold and Flu Multi-Symptom Relief/Cold and Flu Nighttime Relief", "Vicks DayQuil and Vicks NyQuil Cold and Flu Multi-Symptom Relief/Cold and Flu Nighttime Relief", "Vicks DayQuil and Vicks NyQuil Cold and Flu Multi-Symptom Relief/Cold and Flu Nighttime Relief", "Vicks DayQuil and Vicks NyQuil Cold and Flu Multi-Symptom Relief/Cold and Flu Nighttime Relief", "Vicks DayQuil and Vicks NyQuil Cold and Flu Multi-Symptom Relief/Cold and Flu Nighttime Relief", "Vicks DayQuil and Vicks NyQuil HIGH BLOOD PRESSURE COLD and FLU", "Vicks DayQuil and Vicks NyQuil HIGH BLOOD PRESSURE COLD and FLU", "Vicks DayQuil and Vicks NyQuil Severe Cold and Flu", "Vicks DayQuil and Vicks NyQuil Severe Cold and Flu", "Vicks DayQuil and Vicks NyQuil Severe Cold and Flu", "Vicks DayQuil and Vicks NyQuil Severe Cold and Flu", "Vicks DayQuil and Vicks NyQuil Severe Cold and Flu", "Vicks DayQuil and Vicks NyQuil Severe Cold and Flu", "Vicks DayQuil and Vicks NyQuil Severe Cold and Flu", "Vicks DayQuil and Vicks NyQuil Severe Cold and Flu", "Vicks DayQuil and Vicks NyQuil Severe Cold and Flu", "Vicks DayQuil and Vicks NyQuil Severe Cold and Flu", "Vicks Dayquil Cold & Flu", "Vicks Dayquil Cold & Flu Multi-symptom Relief Liquicaps", "Vicks DayQuil Cold and Flu", "Vicks DayQuil COLD and FLU", "Vicks DayQuil Cold and Flu", "Vicks DayQuil Cold and Flu Multi-Symptom Relief", "Vicks DayQuil Cold and Flu Multi-Symptom Relief", "Vicks DayQuil Cold and Flu Multi-Symptom Relief", "Vicks Dayquil Complete Cold & Flu Caplets", "Vicks Dayquil Complete Cold & Flu Liquicaps", "Vicks Dayquil Complete Cold & Flu Liquid", "Vicks DayQuil Cough", "Vicks DayQuil Cough", "Vicks DayQuil Cough", "Vicks Dayquil Cough Cough & Congestion", "Vicks DayQuil Cough DM plus Congestion", "Vicks DayQuil HBP", "Vicks DayQuil HIGH BLOOD PRESSURE Cold and Flu", "Vicks DayQuil HIGH BLOOD PRESSURE COLD and FLU", "Vicks Dayquil Hot Remedy", "Vicks DayQuil HOT REMEDY RAPID RELIEF MULTI-SYMPTOM Cold and Flu plus Congestion", "Vicks DayQuil HOT REMEDY RAPID RELIEF MULTI-SYMPTOM Cold and Flu plus Congestion", "Vicks DayQuil Kids BERRY COLD and COUGH plus MUCUS", "Vicks DayQuil Kids Cold Cough plus Mucus", "Vicks DayQuil Kids Honey and Vicks NyQuil Kids Honey COLD and COUGH plus", "Vicks DayQuil Kids Honey and Vicks NyQuil Kids Honey COLD and COUGH plus", "Vicks Dayquil Liquicaps", "Vicks DayQuil Mucus Control DM", "Vicks DayQuil Nature Fusion Cold and Flu", "Vicks DayQuil Nature Fusion Cough", "Vicks DayQuil Nature Fusion Cough and Chest Congestion", "Vicks DayQuil NyQuil BERRY Kids COLD and COUGH plus", "Vicks DayQuil NyQuil BERRY Kids COLD and COUGH plus", "Vicks DayQuil NyQuil HIGH BLOOD PRESSURE COLD and FLU", "Vicks DayQuil NyQuil HIGH BLOOD PRESSURE COLD and FLU", "Vicks DayQuil NyQuil HOT REMEDY RAPID RELIEF MULTI-SYMPTOM Cold and Flu plus Congestion", "Vicks DayQuil NyQuil HOT REMEDY RAPID RELIEF MULTI-SYMPTOM Cold and Flu plus Congestion", "Vicks DayQuil NyQuil Severe Cold and Flu combo", "Vicks DayQuil NyQuil Severe Cold and Flu combo", "Vicks DayQuil NyQuil Severe Honey Cold and Flu", "Vicks DayQuil NyQuil Severe Honey Cold and Flu", "Vicks DayQuil NyQuil ULTRA CONCENTRATED COLD and FLU", "Vicks DayQuil NyQuil ULTRA CONCENTRATED COLD and FLU", "Vicks DayQuil Severe and Vicks NyQuil Severe Cold and Flu", "Vicks DayQuil Severe and Vicks NyQuil Severe Cold and Flu", "Vicks DayQuil Severe and Vicks NyQuil Severe Cold and Flu", "Vicks DayQuil Severe and Vicks NyQuil Severe Cold and Flu", "Vicks DayQuil Severe Cold and Flu", "Vicks DayQuil Severe Cold and Flu", "Vicks DayQuil Severe Cold and Flu", "Vicks DayQuil Severe Cold and Flu", "Vicks DayQuil Severe Honey Cold and Flu", "VICKS DayQuil SEVERE HONEY FLAVOR COLD and FLU", "Vicks DayQuil Severe Hot Remedy Cold and Flu plus Congestion", "Vicks DayQuil Severe Hot Remedy Cold and Flu plus Congestion", "Vicks DayQuil Tropical and Vicks NyQuil Cherry Cough", "Vicks DayQuil Tropical and Vicks NyQuil Cherry Cough", "Vicks DayQuil ULTRA CONCENTRATED COLD and FLU", "Vicks DayQuil VapoCOOL SEVERE COLD and FLU plus CONGESTION", "VIcks Flu Therapy Severe Cold and Flu Day", "VIcks Flu Therapy Severe Cold and Flu Day", "Vicks Formula 44 Cough", "Vicks Formula 44 Cough and Chest Congestion", "Vicks Formula 44 Cough and Congestion Severe Daytime and Nighttime", "Vicks Formula 44 Cough and Congestion Severe Daytime and Nighttime", "Vicks Formula 44 Cough and Head Congestion", "Vicks Formula 44 Cough and Sore Throat Lozenge", "Vicks Formula 44 Nighttime Cough and Cold", "Vicks Formula 44 VapoCool Cough and Chest Congestion", "Vicks Formula 44 VapoCool Sever Cough and Congestion", "Vicks Formula 44 VapoCool Severe Nighttime Cough and Cold", "Vicks Formula 44d Liq", "Vicks Formula 44dm Cough", "VICKS FORMULA 44DM COUGH and CHEST CONGESTION", "VICKS FORMULA 44DM NIGHTTIME COUGH and COLD", "Vicks Formula 44m Liq", "Vicks Jarabe Cough Congestion", "Vicks NyQuil", "Vicks Nyquil Adult Nighttime Colds Medicine", "Vicks NyQuil Alcohol Free Cold and Flu Nighttime Relief", "Vicks NyQuil Childrens", "Vicks NyQuil childrens COLD and COUGH", "Vicks Nyquil Cold & Flu", "Vicks NyQuil Cold and Flu", "Vicks NyQuil Cold and Flu", "Vicks NyQuil COLD and FLU", "Vicks NyQuil Cold and Flu", "Vicks NyQuil Cold and Flu", "Vicks NyQuil Cold and Flu Nighttime Relief", "Vicks NyQuil Cold and Flu Nighttime Relief", "Vicks NyQuil Cold and Flu Nighttime Relief", "Vicks NyQuil Cold and Flu Nighttime Relief", "Vicks NyQuil Cold and Flu Nighttime Relief", "Vicks NyQuil Cold and Flu Nighttime Relief", "Vicks NyQuil Cold and Flu Nighttime Relief", "Vicks NyQuil Cold and Flu Nighttime Relief", "Vicks NyQuil Cold and Flu Nighttime Relief and Vicks Childrens NyQuil Cold and Cough", "Vicks NyQuil Cold and Flu Nighttime Relief and Vicks Childrens NyQuil Cold and Cough", "Vicks Nyquil Complete Cold & Flu", "Vicks Nyquil Complete Cold & Flu Caplets", "Vicks Nyquil Complete Cold & Flu Liquicaps", "Vicks NyQuil Cough", "Vicks NyQuil Cough", "Vicks NyQuil Cough DM plus Congestion", "Vicks NyQuil D Cold And Flu Nighttime Relief", "Vicks NyQuil D Severe Cold And Flu", "Vicks NyQuil HBP Cold and Flu", "Vicks NyQuil HIGH BLOOD PRESSURE Cold and Flu", "Vicks NyQuil HIGH BLOOD PRESSURE COLD and FLU", "Vicks NyQuil Kids", "Vicks NyQuil Kids BERRY COLD and COUGH plus RUNNY NOSE", "Vicks NyQuil Kids Honey Cold Cough Congestion", "Vicks NyQuil Kids Honey Cold Cough Congestion", "Vicks NyQuil Less Drowsy", "Vicks Nyquil Liquicaps", "Vicks Nyquil Liquicaps Cold & Flu Multi-symptom Relief", "Vicks NyQuil Nature Fusion Cold and Flu Nighttime Relief", "Vicks NyQuil Severe Cold and Flu", "Vicks NyQuil Severe Cold and Flu", "Vicks NyQuil Severe Cold and Flu", "Vicks NyQuil Severe Cold and Flu", "Vicks NyQuil Severe Honey Cold and Flu", "VICKS NyQuil SEVERE HONEY FLAVOR COLD and FLU", "Vicks NyQuil Severe Hot Remedy Cold and Flu plus Congestion", "Vicks NyQuil Severe Hot Remedy Cold and Flu plus Congestion", "Vicks NyQuil ULTRA CONCENTRATED COLD and FLU", "Vicks NyQuil VapoCOOL Severe COLD and FLU plus CONGESTION", "Vicks Pediatric Formula 44 Liq", "Vicks Pediatric Formula 44d Liq", "Vicks Pediatric Formula 44e Liq", "Vicks Pediatric Formula 44m Liq", "Vicks Severe Cold and Flu", "Vicks Severe Cold and Flu", "Viravan PDM", "Virdec DM Drops", "Viro Flu PM Relief", "Vito Bronches Sirop", "Viva Cold & Flu All In One Relief Caplets", "WAG HBP Daytime and Nighttime Cold and Flu", "WAG HBP Daytime and Nighttime Cold and Flu", "Wal Flu Severe", "Wal Flu Severe Cold", "Wal Flu Severe Cold and Cough Daytime", "Wal Flu Severe Cold and Cough Daytime Nighttime", "Wal Tussin", "Wal Tussin Adult Cough and Cold", "Wal Tussin CF Cough and Cold", "Wal Tussin CF Max", "Wal Tussin CF Max Multi Symptom Cough Cold and Flu", "Wal Tussin Cough and Chest Congestion", "Wal Tussin DM", "Wal Tussin DM Adult Cough and Chest Congestion", "Wal Tussin DM Max", "Wal Tussin DM Max", "Wal Tussin DM Max Cough and Chest Congestion", "Wal Tussin DM Max Nighttime Wal Tussin DM Max", "Wal Tussin DM Max Nighttime Wal Tussin DM Max", "Wal-Phed PE Multi Symptom", "Wal-Phed PE Pressure plus Pain plus Cold Daytime, Nighttime, Multi-Symptom", "Wal-Phed PE, Multi-Symptom, Daytime, Nighttime", "Wal-Phed PE, Multi-Symptom, Non-Drowsy", "Wal-Tussin", "Wal-Tussin DM", "Walgreen Adult Cough Plus Chest Congestion DM", "Walgreen Childrens COLD PLUS COUGH PLUS SORE THROAT", "Walgreen Cough and Chest Congestion", "Walgreen Day Time NightTime Cold and Flu Relief", "Walgreen Day Time NightTime Cold and Flu Relief", "Walgreen Day Time Nighttime Cold and Flu Relief Honey Flavor", "Walgreen Day Time Nighttime Cold and Flu Relief Honey Flavor", "Walgreen DayTime Cold and Flu Relief", "Walgreen Daytimel Kids Cold Cough plus Mucus", "Walgreen High Blood Pressure Nighttime Cold and Flu", "Walgreen Nighttime Cold and Flu", "Walgreen Nighttime Cold and Flu Relief", "Walgreen NightTime Cold and Flu relief", "Walgreen Severe Multi-Symptom Cough Cold Flu", "Walgreens Adult Nighttime Wal Tussin DM Max Maximum Strength", "Walgreens Childrens", "Walgreens Childrens Cold plus Cough plus Runny Nose", "Walgreens DAY and NIGHT PACK", "Walgreens DAY and NIGHT PACK", "Walgreens Daytime Childrens", "Walgreens Daytime Nighttime Wal-Flu Severe Cold and Cough Kit", "Walgreens Daytime Non-Drowsy Cold and Flu", "Walgreens Daytime Non-Drowsy Cold and Flu", "Walgreens Daytime non-drowsy cold multi-symptom for adults", "Walgreens Daytime Wal-Flu Severe Cold and Cough Berry infused with Menthol and Green Tea flavors", "Walgreens Grape Flavor", "Walgreens High Blood Pressure Cold and Flu", "Walgreens Maximum Strength Non Drowsy Day and Night Cold and Flu", "Walgreens Maximum Strength Non Drowsy Day and Night Cold and Flu", "Walgreens Maximum Strength Non Drowsy Day and Night Cold and Flu", "Walgreens Maximum Strength Non Drowsy Day and Night Cold and Flu", "Walgreens Maximum Strength Non-Drowsy Day and Night Sinus and Cold", "Walgreens Maximum Strength Non-Drowsy Day and Night Sinus and Cold", "Walgreens Maximum Strength Non-Drowsy Day and Night Sinus and Cold", "Walgreens Maximum Strength Non-Drowsy Day and Night Sinus and Cold", "Walgreens Maximum Strength Severe Congestion and Cough", "Walgreens Mixed Berry Benz-Dex Lozenges", "Walgreens NightTime Cold and Flu", "Walgreens NightTime Cold and Flu", "Walgreens NightTime Cold and Flu", "Walgreens Nighttime Kids Honey Cold Cough Congestion", "Walgreens Severe Cold Multi-Symptom For Adults", "Walgreens Severe Warming Cold and Flu For Adults", "WalTussin DM Max", "WalTussin DM Max", "Welby Day Time Cold and Flu", "Welby Nighttime Cold and Flu", "Well At Walgreens Multi-Symptom Severe Cold Green Tea and Honey Lemon flavors", "Well at Walgreens Multi-Symptom Wal-Flu Severe Cold and Nighttime Wal-Flu Severe Cold and Cough Kit", "Western Family Daytime Severe Cold and Cough Berry infused with Menthol and Green Tea flavors", "WesTussin DM", "WesTussin DM NF", "Whituben", "Winco Foods Childrens Multi Symptom Cold", "WinCo Foods Daytime Severe Cold and Cough Berry infused with Menthol and Green Tea flavors", "Winco Foods Multi-Symptom Severe Cold Green Tea and Honey Lemon flavors", "XL-3 Day Time", "XL-3 Day Time", "XL-3 Xtra", "XL-3 Xtreme", "XL-3 Xtreme", "Xl3 Xtra", "Xpect Cough Relief", "Xpecto soothing relief", "Xpecto soothing relief", "Y-Cof DMX", "Z-cof 1", "Z-cof 12 DM", "Z-dex", "Zicam", "Zicam", "Zicam", "Zicam", "Zicam Cough MAX", "Zicam Multi-symptom Cold & Flu Daytime", "Zicam Multi-symptom Cold & Flu Nighttime", "ZoDen DM", "Zyncof", "Zyncof" ]	[ "Benylin DM", "Romilar", "Triaminic", "Vicks Formula 44" ]	[ "Premier Value Chest Congestion and cough releif DM", "Brompheniramine Maleate, Pseudoephedrine Hydrochloride, Dextromethorphan Hydrobromide", "BPM Mal Phenyleph HCl DM HBr", "Pyril Mal Phenyl HCl Dex HBr", "Sildec DM", "Chlorphen Mal Dex HBr Pseudoeph HCl", "Re Dcp Drops", "Brom Mal Phenyl HCl Dex HBr", "Trital DM", "Phenylephrine Complex", "Quartuss", "Deconsal DM", "Dextromethorphan Tannate, Phenylephrine Tannate, Dexchlorpheniramine Tannate", "Dextro Phenyl Pyril", "Atuss DS Tannate Suspension", "Little Colds Decongestant Plus Cough", "Carbofed DM", "CVS Chest Congestion Relief DM", "Bromdex D", "Multi-Symptom Daytime Cold", "Guiadrine DX", "Mintuss DR", "Quartuss DM", "Mucinex DM", "Mucinex DM", "Promethazine DM", "Ht-tuss DM", "Childrens Mucinex Cough", "Zicam", "Robitussin Cough and Cold D", "N - Time", "Premier Value day time severe cold and cough berry infused with menthol and green tea flavors", "Vicks NyQuil Cold and Flu Nighttime Relief", "Vicks 44 D", "Our Family day time severe cold and Cough berry infused with menthol and green tea flavors", "Bronkids", "TopCare Nite Time Cold and flu", "Vicks 44 M", "Brontuss DX", "Sanatos Day", "TopCare day time severe cold and cough berry infused with menthol and green tea flavors", "Sanatos Night", "Robitussin Cough and Cold D", "ACETAMINOPHEN, DEXTROMETHORPHAN HYDROBROMIDE, and DOXYLAMINE SUCCINATE", "Freds Chest Congestion Relief DM", "Zicam", "ACETAMINOPHEN, DEXTROMETHORPHAN HYDROBROMIDE, and PHENYLEPHRINE HYDROCHLORIDE", "Rite Aid day time severe cold and cough berry infused with menthol and green tea flavors", "Vicks 44 E Cough and Chest Congestion Relief", "DG Health cold multi symptom nite time", "Brontuss SF", "D - Time", "CVS day time cough and severe cold berry infused with menthol and green tea flavors", "Diabetic Tussin DM", "Guaifenesin DM", "Guaifenesin DM", "Vicks NyQuil Less Drowsy", "Bisolvine Child", "Runny Nose and Cough", "Alka-Seltzer Plus Day Non Drowsy Cold Medicine Citrus", "Alka-Seltzer Plus Night Cold Medicine", "Vicks NyQuil Cold and Flu Nighttime Relief", "Quality Choice day time severe cold and cough berry infused with menthol and green tea flavors", "Head Congestion Cold Relief", "Head Congestion Cold Relief", "Cough and Cold", "Vicks NyQuil", "Expectorant plus Cough Relief", "Maximum Strength Flu", "Q Tussin DM", "P-Tuss DM", "Cepacol SORE THROAT AND COUGH", "CounterAct Cough", "Nasohist DM Pediatric", "Tussin DM", "Guaifenesin DM", "Guaifenesin DM", "Sildec PE DM", "Promethazine DM", "Flutabs", "LEADER iNTENSE COUGH RELIEVER", "Double Tussin Intense Cough Reliever DM", "Ceron DM", "Daytime Cough And Cold", "Q-Tapp DM Elixir", "Bromhist PDX", "Corfen DM", "Simuc DM", "Tusdec DM", "AccuHist PDX", "Viravan PDM", "Bronkids", "Sonahist DM", "Reme Hist DM", "Dcp", "Triplex DM", "Promethazine Hydrochloride and Dextromethorphan Hydrobromide", "Rondamine DM", "Neutrahist PDX Drops", "Delsym Night Time Multi-Symptom", "Broncotron", "Broncotron D", "Guaifenesin-DM Nr", "Sildec PE DM", "Night Time Cold/Flu Relief Cherry", "Night Time Cold/Flu Relief Original", "Tussin CF", "Day Time Gelcap", "Kids-EEZE Cough and Cold", "Tussin DM", "Tussin CF", "Good Neighbor Pharmacy Cold Multi Symptom", "Panatuss Pediatric Drops DXP", "Night Time Cold/Flu Relief Cherry", "Leader Chest Congestion Relief Plus DMDM DM", "Carbinoxamine/Pseudoephedrine/DM", "Cepacol Sore Throat and Cough", "Entex PAC", "Robitussin Cough and Chest Congestion DM Max", "Day Time Cold/Flu Relief", "Green Guard Cough and Cold Relief", "Medique Decorel Forte Plus", "Medi-First Cold Relief", "Medi-First Plus Cold Relief", "Moore Medical MooreBrand Severe Cold Relief", "Bromphenex DM", "Night Time Cold/Flu Relief Original", "Dextromethorphan Hydrobromide and Promethazine Hydrochloride", "Guaifenesin DM", "Guaifenesin DM", "Robitussin Night Time Cough, Cold and Flu", "Sudatex - DM", "Bio T Pres-B", "Robitussin Cough and Cold Long Acting", "Robitussin Cough and Chest Congestion DM", "Robitussin Cough and Chest Congestion Sugar Free DM", "Tussin Sugar Free Cough", "EndaCof Drops", "Cold Relief Severe Pain Cough", "Vicks NyQuil Cold and Flu", "LoHist PSB DM", "EndaCof PD", "Guiatuss DM", "Robitussin Cough and Cold CF Max", "ConRx Cold", "Childrens Tylenol Plus Multi-Symptom Cold", "Sudatex - DM", "Vicks DayQuil Cold and Flu", "Dicel DM", "Guaifenesin DM", "Gadavyt Cough DM", "Bio-Z-Cough", "Childrens Mucinex Cough", "TYLENOL COUGH and SORE THROAT", "Physicians Care Cold and Cough", "Physicians Care Cold and Cough", "Brontuss SF-NR", "Cold Head Congestion", "Panatuss DXP", "MyHist DM", "Y-Cof DMX", "PE Hist DM", "Night Time Cough", "Nighttime Cold and Flu Relief", "Night time cold/flu relief multi symptom", "Day Time Cold and Flu Relief", "Safetussin DM", "Safetussin CD", "Daytime Cough and Cold", "Preferred Plus TabTussin DM DMTDM", "Preferred Plus Chest Congestion Relief DMTDM TDM", "Night Time Cold/Flu Relief Original", "Night Time Cold/Flu Relief Cherry", "Bronkids", "Robitussin Cough and Cold CF", "ConRx Cold", "Cepacol Extra Strength Sore Throat mixed berry", "Q Tussin DM", "Multi Sympton Cold Day Night", "Multi Sympton Cold Day Night", "Multi Sympton Cold Day Night", "Multi Sympton Cold Day Night", "CHILDRENS TYLENOL PLUS COUGH and SORE THROAT", "Childrens Tylenol Plus Flu", "Bronco-Flu Plus", "Bronco-Flu Des", "Bronkisan", "Promethazine DM", "Broncotron S", "Daytime Nighttime Cold/flu Relief A P J", "Daytime Nighttime Cold/flu Relief A P J", "SohMed Cold Relief", "Balamine DM Syrup", "BromfedDM DM", "Pulmovac", "Green Tussin DM", "Daytime Multi-Symptom Cold/Flu Relief", "NiteTime Multi-Symptom Cold/Flu Relief", "Night-Time Cherry MULTI-SYMPTOM COLD/FLU RELIEF", "Night-Time Original MULTI-SYMPTOM COLD/FLU RELIEF", "DM MAX Maxium Strength", "Brontuss", "Scot-Tussin DM SF Maximum Strength Cough Cold", "Tussin DMMaximum Strength", "Sildec PE DM", "Tl-hist DM", "Childrens Cold, Cough and Sore Throat", "Night Time Gelcap", "Cosedal Drops", "Day Time Gelcap", "Broncotron PED", "Broncotron PED", "Childrens Multi-Symptom Cold", "Night time cold and flu", "Mucus Relief Severe Congestion and Cough Maximum Strength", "Bronco Pulmonar Syrup", "Scot-Tussin Senior SF DMEXP", "Libera Tos", "Libera Tos", "Libera Tos", "Adult Cold, Flu and Sore Throat", "Nighttime cold and flu", "Tylenol Cold Head Congestion Severe", "Childrens Tylenol Plus Multi-Symptom Cold", "CVS Pharmacy Daytime Nighttime Severe Cold and Cough Kit", "Bionel Pediatric", "Bionel", "Z-dex", "Childrens Mucinex Congestion and Cough", "Endacon", "Childrens Mucus Relief COUGH", "Severe Congestion and Cough MAX Maxium Strength", "Green Tussin SUGAR FREE DM", "Adult Severe Congestion and Cough", "Tylenol Cold Head Congestion Severe", "Night Time MULTI-SYMPTOM COLD/FLU RELIEF", "Tussin DM COUGH SUPPRESSANT/EXPECTORANT", "Tylenol Cold Multi-Symptom", "CVS Pharmacy Daytime Severe Cough and Cold Berry infused with Menthol and Green Tea flavors", "TYLENOL COLD Cough and Severe Congestion", "Shopko Chest Congestion Relief DMTDM TDM", "Day Time Cold/Flu Relief", "Good Sense Tussin DM Cough and Chest Congestion", "Baczol Cold Medicine", "Cheracol D Cough Formula 4oz", "Nighttime Cold Flu Relief", "Cpm-pse DM", "ZoDen DM", "Promethazine HCl and Dextromethorphan Hydrobromide", "Mesehist DM", "Trigofen DM", "Tri-dex PE", "Tl-hist DM", "Mucinex Fast-Max Day Time Severe Cold and Mucinex Fast-Max Night Time Cold and Flu Maximum Strength", "Broncomar", "DayTime Cold and Flu", "Alka-Seltzer Plus Severe Cough and Cold Day and Night", "Alka-Seltzer Plus Severe Cough and Cold Day and Night", "Siltussin DM", "TRISPEC DMX Pediatric Drops Cough Suppressant Expectorant CHERRY RASPBERRY Flavor", "Balahist DM Syrup", "Daytime Nighttime Cold/Flu", "Daytime Nighttime Cold/Flu", "Mucosa DM", "Childrens Delsym Cough Plus Cold Day Time", "HealthMart Mucus Relief FM", "HealthMart Mucus Relief FM", "CVS Sore Throat Mixed Berry Flavor", "Virdec DM Drops", "Broncomar DM", "Broncomar Maximum", "G-Tuss-NL Ped", "G-Xpect PSE", "G-Tuss-NL", "Vicks DayQuil Nature Fusion Cough and Chest Congestion", "Vicks NyQuil Nature Fusion Cold and Flu Nighttime Relief", "Vicks DayQuil Nature Fusion Cold and Flu", "Multi-Symptom Relief Cold and Flu Multi-Symptom Relief", "Robitussin Peak Cold Daytime Cold Plus Flu", "Tussin DM", "Tussin CF", "Despec DM", "Coricidin HBP Cough and Cold Cough Suppressant, Antihistamine", "Delsym Cough Plus Cold Day Time and Delsym Cough Plus Cold Night Time", "Tussin CF", "Altidome DMX", "Biogtuss TR", "Daytime Nighttime Cold/flu", "Daytime Nighttime Cold/flu", "Cold Multi-Symptom Day-time", "ConRx NightTime", "Cough Multi Symptom", "Cough and Sore Throat Daytime", "Cough and Sore Throat Nighttime", "Pain Reliever Fever Reducer", "CounterAct Day", "Select Brand Tab Tussin DM", "Select Brand Mucus Relief DM", "ConRX DayTime", "TopCare Daytime Severe Cold and Cough Berry infused with Menthol and Green Tea flavors", "Promethazine DM", "Childrens Mucinex Mini-Melts Cough", "Harris Teeter Tussin", "LoHist PEB DM", "ExeFen DMX", "Bronco Silen-DM", "Cough and Congestion DM", "Permavan External Patch", "Z-cof 12 DM", "Nasohist DM Pediatric", "BP8 Cough", "Brom/PSE/DM Cough", "Brompheniramine Pseudoephedrine DM", "Family Care Multi Symptom Cold", "Family Care Cold and Flu Multi Symptom", "Multi-Symptom Cold Warming Effect Daytime", "Mucinex Fast-Max Day Time Severe Cold and Mucinex Fast-Max Night Time Cold and Flu Maximum Strength", "Altilan CL", "Altidesp", "Biospec DMX", "Neutrahist PDX Drops", "Acetaminophen,Dextromethorphan,Phenylephrine", "Cold Multi-Symptom Daytime Non-Drowsy", "Walgreens Daytime Nighttime Wal-Flu Severe Cold and Cough Kit", "Well At Walgreens Multi-Symptom Severe Cold Green Tea and Honey Lemon flavors", "Well at Walgreens Multi-Symptom Wal-Flu Severe Cold and Nighttime Wal-Flu Severe Cold and Cough Kit", "Xl3 Xtra", "Daytime Multi-Symptom Cold Relief", "Severe Cold Relief", "Multi-Symptom Daytime Cold", "Multi-Symptom Nighttime Cold", "Cardec DM", "Cold and Flu Relief Multi Symptom Nighttime", "Brompheniramine Phenylephrine DM", "G-bronco-D", "Dr. Cocoa Daytime Cough and Cold", "Aldex GS DM", "Z-cof 1", "Mucus Relief Plus", "Multi-Symptom Daytime Cold", "Flu Relief Therapy Daytime Severe Cold", "Mucus Relief DM", "Nighttime Cold and Flu Relief Plus", "Multi-Symptom Cold Relief", "Day-Time Night-Time", "Day-Time Night-Time", "Daytime cold and flu relief", "Daytime Cold and Flu Relief", "Daytime Cold and Flu Relief Plus", "Mucus Relief DM", "Severe Multi-Symptom Cold", "Alticotron", "Cold and Flu Relief Daytime Non Drowsy", "Promethazine Hydrochloride and Dextromethorphan Hydrobromide", "Rite Aid Daytime Severe Cold and Cough Relief", "Childrens Mucinex Multi-Symptom Cold", "Klernaz", "TYLENOL COLD Multi-Symptom", "ShopRite DayTime Flu Plus Severe Cold And Cough", "SMITH BROS NON-DROWSY DAY TIME COLD and FLU", "Cold and Cough PE", "Cold and Flu Multi-Symptom Daytime Nighttime", "Cold and Flu Multi-Symptom Daytime Nighttime", "NightTime Multi-Symptom Flu Cold", "Cold and Flu Relief Multi-Symptom, Nighttime", "Cold and Flu Nighttime", "Daytime Cold and Flu Relief", "Cold and Flu Daytime", "Nighttime Multi-Symptom Cold and Flu Relief", "Nighttime Multi-Symptom Cold and Flu Relief", "Non-Drowsy Daytime Multi-Symptom Cold and Flu", "TYLENOL Cold Multi-Symptom Daytime", "Tussin DM Max non drowsy", "WinCo Foods Daytime Severe Cold and Cough Berry infused with Menthol and Green Tea flavors", "DESGEN DM Tabs", "Cold and Flu Daytime Nighttime", "Cold and Flu Daytime Nighttime", "Tukol Maxium Strength Cough and Mucus Relief", "Daytime Multi-Symptom Non-Drowsy Cold and Flu", "Bisolvine Adult", "SMITH BROS NON-DROWSY MULTI-SYMPTOM COLD and FLU", "SMITH BROS NIGHT TIME COUGH and CONGESTION", "Next Night Time Cold and Flu Relief", "Next Day Time Non drowsy Cold and Flue", "Bisolvine Adult", "Walgreens Daytime Wal-Flu Severe Cold and Cough Berry infused with Menthol and Green Tea flavors", "Childrens Mucinex Cough", "Multi-Symptom Daytime and Nighttime Cold and Flu Relief Plus", "Multi-Symptom Daytime and Nighttime Cold and Flu Relief Plus", "Pediatex TDM", "Corfen DM", "Pyril DM", "Tussin DM", "Cepacol Sore Throat and Cough", "Delsym Night Time Cough and Cold", "Delsym Night Time Multi Symptom", "Nighttime Multi-Symptom Cold", "Non Drowsy Cold and Cough PE", "PE multi-stymptom cold and cough relief", "Despec DM Tabs", "Defensol-ito", "Family Care Cold and Flu Nighttime", "Family Care Cough Nighttime", "Family Care Cough and Cold", "Family Care Cold and Flu Multi Symptom", "Tylenol Cold Multi-symptom Daytime", "Day Time Cold non drowsy cold and Flu Relief", "Nighttime Cold and Flu Relief", "Zyncof", "DayTime Multi-Symptom Flu Cold Medicine", "Western Family Daytime Severe Cold and Cough Berry infused with Menthol and Green Tea flavors", "Goyescas 7 Syrups Alcohol and Sugar Free Cough and Cold", "Goyescas Broncovac 3 Cough and Cold", "Goyescas 7 Syrups with Bee Honey Cough and Cold", "Goyescas Broncovac 1 Cough and Cold", "Goyescas 7 Syrups Original Cough and Cold", "Goyescas Broncovac 2 Cough and Cold", "Daytime and Nighttime Cold and Flu Relief Plus", "Daytime and Nighttime Cold and Flu Relief Plus", "Night Time Pseudo-Free", "Flu Relief Therapy Day Time", "Day and Night Cold PE", "Kroger DayTime Flu plus Severe Cold and Cough", "HEB DayTime Flu And Severe Cold And Cough", "Despec NR", "Best Choice Daytime Severe Cold and Cough Berry infused with Menthol and Green Tea flavors", "Glenmax PEB DM FORTE", "Glenmax PEB DM", "Glentuss", "Severe Cold and Flu Relief", "Guaifenesin DM", "Q Tussin DM", "Mucinex Fast-Max DM Max", "Mucinex Fast-Max Severe Cold", "Safeway Daytime Cold and Flu Relief", "Broncochem Expectorant II", "Broncochem Maximum Cough", "Nite Time Cold and Flu", "Cough and Congestion DM", "Day Time Cold and Flu cold and flu multi symptom relief", "Multi-Symptom Cold Relief", "Multi-Symptom Cold Relief", "Acetaminophen,Dextromethorphan,Doxylamine", "Bpm-DM-phen", "Mucus Relief DM Expectorant and Cough Suppressant", "Severe Cold Multi-Symptom", "Cold Head Congestion Severe", "Aspirin Free Cold Head Congestion Day Time", "Cold and Flu Severe", "Dometuss-G", "Cold Head Congestion Non-Drowsy", "Daytime Cold and Pain Relief", "Cold and Flu Relief Severe", "Head Congestion and Cold Relief Daytime", "Childrens Mucinex Multi-Symptom Cold", "Prometh with Dextromethorphan", "Cold-EEZE Daytime Cold and Flu", "Chest Congestion Childrens Plus Cough", "Day Time Cold Multi-Symptom", "Cold-EEZE Childrens Daytime Cough and Chest Congestion Relief", "Q-Tapp DM", "Premier Value Multi-Symptom Severe Cold Green Tea and Honey Lemon flavors", "Dimetane DX", "Maximum Strength Nighttime Cold/Flu Relief", "Equaline Chest Congestion Relief DM DM", "Mucinex Fast-Max Severe Congestion and Cough Liquid Pouches", "Triacting Daytime Cold Cough Childrens", "Robafen DM Cough Sugar Free Clear", "Topcare Cold", "Topcare Cold", "Maximum Strength Mucus Relief Cold Flu and Sore Throat", "Maximum Strength Flu HBP", "Flu BP Maximum Strength", "Promethazine Hydrochloride and Dextromethorphan Hydrobromide", "Wal-Phed PE, Multi-Symptom, Non-Drowsy", "Winco Foods Multi-Symptom Severe Cold Green Tea and Honey Lemon flavors", "Nighttime Cold and Flu ReadyInCase", "Vicks NyQuil Cold and Flu Nighttime Relief and Vicks Childrens NyQuil Cold and Cough", "Vicks NyQuil Cold and Flu Nighttime Relief and Vicks Childrens NyQuil Cold and Cough", "Vicks NyQuil D Cold And Flu Nighttime Relief", "Tussin DM Max Cough and Chest Congestion", "Maximum Strength Flu HBP", "Mucus Relief Maximum Strength", "High Blood Pressure Chest Congestion and Cough", "Mucinex Fast-Max Cold, Flu and Sore Throat", "Mucinex Fast-Max Day Time Severe Cold and Mucinex Fast-Max Night Time Cold and Flu Maximum Strength", "Mucinex Fast-Max Severe Congestion and Cold", "Defensol D (Multi Symptom Effervescent Tablets)", "CareOne Daytime Severe Cold and Cough Berry infused with Menthol and Green Tea flavors", "Quality Choice Daytime Severe Cold and Cough Berry infused with Menthol and Green Tea flavors", "Codituss DM", "Multi-Symptom Cold Relief", "Multi-Symptom Cold Relief", "Q Tussin DM", "Iophen DM NR", "Ru-hist Plus", "Kroger Cough Cold and Flu", "Topcare Severe Sinus Congestion", "Topcare Cold and Cough", "Topcare Cold and Flu", "Broncomar DM", "Broncomar EXPECTORANT", "Mucinex DM", "Adult Aurotussin Maximum Strength Nighttime Cough DM", "Mucinex DM", "Immediate-release Mucus Relief DM", "Bio-G-Tuss Pediatric Drops", "Theraflu ExpressMax Daytime Nighttime Value Pack", "Cold Relief Multi-symptom, Daytime", "Daytime Cold and Flu", "Multi-Symptom Cold Relief Daytime, Nighttime", "Multi-Symptom Cold Relief Daytime, Nighttime", "Meijer Daytime Severe Cold and Cough Berry infused with Menthol and Green Tea flavors", "Meijer Multi-Symptom Severe Cold Green Tea and Honey Lemon flavors", "Nighttime Cold and Flu", "Robi DM Max Cough Congestion 10ct Blister", "Q Tapp Cold and Cough", "DayTime Cold and Flu", "DayTime Cold and Flu", "Mucus Relief DM", "Calmadol Plus", "Dg Health Tussin DM Adult", "Childrens Multi Symptom Cold", "Childrens Mucinex Multi-Symptom Cold and Fever", "Childrens Mucinex Cold, Cough and Sore Throat", "Childrens Mucinex Cough", "Assured Maximum Strength Mucus Relief", "Broncochem Cold and Flu Caplets", "Chest Congestion Relief", "Chest Congestion Relief", "Theraflu Max-D", "Severe Congestion and Cough Relief", "Coltalin-DM", "Triaminic Multi-Symptom Fever", "Cough Suppressant and Expectorant DM", "Nite Time Cold Flu Relief", "Duraflu", "Poly-tussin DM", "Premier Value Multi-Symptom Severe Cold Green Tea and Honey Lemon flavors", "Dextromethorphan Hydrobromide and Promethazine Hydrochloride", "Cough and Cold Relief HBP", "Night Time Cough Cherry", "Childrens Plus Multi-Symptom Cold Grape with PE", "Night Time Cherry Pseudo-Free", "Tussin DM", "Childrens Plus Cough and Runny Nose", "Tussin CF", "Childrens Plus Cough and Runny Nose", "Night Time Cherry Pseudo-Free", "Daytime Nighttime Cold/flu", "Daytime Nighttime Cold/flu", "Tussin Sugar Free Cough", "Flu Relief Therapy Day Time", "Triacting Cough and Sore Throat Grape", "Smart Sense Nighttime Cold and Flu Relief Multi Symptom", "Up and Up Nighttime Cold and Flu", "Leader Cold Head Congestion", "SanaTos COLD Multi-Symptom", "SanaTos COLD Multi-Symptom", "Family Care Cold and Flu Multi Symptom Relief SGC Daytime", "Maximum Strength Mucus Relief Cold,Flu and Sore Throat", "Maximum Strength Mucus Relief Severe Congestion and Cough", "Good Sense Day Time", "Good Sense Night Time Cold and Flu", "Good Sense Night Time Cold and Flu", "Good Sense Night Time", "Good Sense Mucus Relief Severe Congestion and Cold", "ShopRite Cold Multi Symptom", "Dextromethorphan HBr, Guaifenesin", "PediaCare Childrens Plus Cough and Runny Nose", "PediaCare Childrens Plus Cough and Sore Throat", "PediaCare Childrens Cough and Congestion", "Multi-Symptom Cold and Cough Daytime Nighttime", "Leader Childrens Mucus Relief", "Mucus Relief DM", "Cough and Cold Relief HBP", "Day Time with PE", "Sound Body Tussin DM", "Night Time Cherry Pseudo-Free", "Nighttime Cold Head Congestion", "Flu Relief Therapy Day Time", "ShopRite Adult Tussin", "Cold Head Congestion Severe", "Tussin DM adult cough and chest congestion", "ShopRite Severe Cold", "Multi Symptom Cold Childrens", "Nite Time Cold and Flu Relief", "Daytime", "Nighttime Cold Flu Relief", "Tussin CF Max", "Nite Time Multi symptom cold flu relief", "Childrens Pain Relief Plus Cough and Sore Throat", "Nite Time", "NiteTime", "Mucus Relief Cough and Congestion DM", "Theraflu Warming Relief Daytime Multi-Symptom Cold Caplets", "Theraflu Warming Relief Nighttime Multi-Symptom Cold Caplets", "Good Neighbor pharmacy severe night time", "DayTime Cold and Flu Relief", "NightTime Cold and Flu Relief", "Little Colds Multi Symptom Cold plus Fever", "good neighbor pharmacy Night time", "Pain Relief Plus", "Good Neighbor Pharmacy Cold", "Cold and Flu Severe", "NiteTime Cold and Flu", "Equaline nighttime cold multi symptom", "Cold relief", "Cough and Sore Throat Non Drowsy", "Theraflu ExpressMax Severe Cold and Flu Caplets", "RelCof DM", "Up and Up mucus relief severe congestion and cough", "Tusnel Diabetic", "Myphetane DX", "Night Time Original Pseudo-Free", "Tussin Sugar Free Cough", "Theraflu Warming Relief Daytime Severe Cold And Cough", "Childrens Plus Flu with PE", "Night Time Cherry Pseudo-Free", "Childrens Plus Cough and Runny Nose", "Tussin Sugar Free Cough", "Night Time Cough and Sore Throat Cool Blast", "Night Time Original Pseudo-Free", "Night Time Original Pseudo-Free", "Day Time with PE", "Tussin CF", "Day Time with PE", "Night Time Cherry Pseudo-Free", "Cough and Cold HBP Decongestant-free", "Circle K Daytime Cold and Flu", "Alka-Seltzer Plus Severe Sinus and Cold", "NyQuil Cold and Flu", "Childrens Dimetapp Multisymptom Cold and Flu", "Carepanto", "Panto Flu", "COLDTAC Plus", "Flu Relief Therapy", "PhysiciansCare Cold and Cough Non-Drowsy", "NightTime Cold and Flu", "Non-Drowsy DayTime Cold and Flu Multi-Symptom Relief", "Up and Up Cold and Head Congestion", "Up and Up Childrens Mucus Relief and Cough", "Up and Up Cold Relief", "Up and Up Cold Relief", "Up and Up adult cough formula DM Non drowsy", "Up and Up Adult Cough and Cold", "Up and Up Cold Flu Relief multi symptom night", "Broncomar Maximun Cough Relief", "Triaminic Multi-Symptom Fever and Cold", "Cold Relief Daytime", "Xpecto soothing relief", "Acetaminophen Dextromethorphan Hydrobromide Doxylamine Succinate Phenylephrine Hydrochloride", "Acetaminophen Dextromethorphan Hydrobromide Doxylamine Succinate Phenylephrine hydrochloride", "Theraflu ExpressMax Severe Cold and Flu Syrup", "Acetaminophen Dextromethorphan Hydrobromide Phenylephrine Hydrochloride", "Acetaminophen Dextromethorphan Hydrobromide Phenylephrine Hydrochloride", "Childrens SUDAFED PE Cold plus Cough", "Pain Relief Cold Multi Symptom", "Equaline Daytime Cold Multi Symptom", "Care One Cold Multi Symptom", "Topcare Cold Multi Symptom", "DiBromm DM", "Theraflu Daytime Severe Cold and Cough", "Biocotron PED", "Nite-Time COLD/FLU ORIGINAL", "Tussin DM Cough and Chest Congestion", "Good Neighbor Pharmacy Day Time", "Equaline adult tussin cough and chest congestion", "Equaline Daytime Nighttime Cold and Flu Relief", "Equaline Daytime Nighttime Cold and Flu Relief", "Good Neighbor Pharmacy Mucus Relief Severe Congestion and Cold", "Good Neighbor Pharmacy Night Time", "Night Time Cherry Pseudo-Free", "Mucinex Fast-Max Severe Cold", "Tussin CF", "Night Time Original Pseudo-Free", "TRISPEC PSE Pediatric Drops Cough Suppressant Expectorant Nasal Decongestant GRAPE Flavor", "Tussin DM", "Night Time Cherry Pseudo-Free", "Q Tapp Cold and Cough", "Equate Nite Time Cold Flu Relief", "Equate NiteTime", "Broncochem Kids Allergy Control", "Broncochem Maximum Cough Kids", "Tussin DM", "Mucus Relief Cold Flu and Sore Throat", "Cold and Flu Relief", "Night Time Cough Cherry", "Coricidin HBP Day and Night", "Coricidin HBP Day and Night", "Safetussin DM", "Preferred Plus Mucus Relief", "Safetussin PM", "Guaifenesin DM", "Mucus Relief DM Max Maximum Strength", "Mucus Relief Cold, Flu and Sore Throat Maximum Strength", "Day Time with PE", "Childrens Plus Cough and Runny Nose", "Tussin Sugar Free Cough", "Childrens Plus Cough and Sore Throat", "Night Time Original Pseudo-Free", "Tussin CF Multi-Symptom Cold", "Night Time Cherry Pseudo-Free", "Childrens Plus Multi-Symptom Grape with PE", "Mucinex Sinus-Max Severe Congestion Relief", "Mucinex Fast-Max Night Time Cold and Flu", "Sudafed PE Pressure plus Pain plus Cough", "Relhist DMX", "Fulton Street Market Cold", "Fulton Street Market cold and flu", "Up and Up Cold Flu Relief", "FormuCare Cough Syrup DM", "Up and Up Tussin Multi Symptom Cold Maximum Strength", "Preferred Plus Severe Cold Cough and Flu", "Up and Up Childrens Cold and Cough", "Up and Up Cold and Flu Relief", "Up and Up Cold Flu Relief", "Preferred Plus Severe Cold Day Time Cold and Flu Night Time", "Nighttime Cold and Flu Relief", "Preferred Plus Severe Sinus Congestion", "Cold and Flu Relief Daytime Nighttime", "Cold and Flu Relief Daytime Nighttime", "Up and Up Mucus Relief Cold Flu and Sore Throat", "Up and Up Mucus Relief Severe Congestion and Cold", "Fulton Street Market Night Time Cold and Flu", "Up and Up Adult Cough Formula DM Max", "Up and Up Cold Flu Relief", "Up and Up Cold Flu Relief", "Preferred Plus Day Time Cold and Flu", "Up and Up Flu and Severe Cold and Cough Relief", "Good Sense night time cold and flu", "PhysiciansCare Cold and Cough Non-Drowsy", "Guaifenesin and Dextromethorphan Hydrobromide", "DG Health Fast Acting Mucus Relief Severe Congestion and Cold", "Simply Right Night Time", "Harris Teeter Day Time", "simply right Night Time", "DG Health Cold Head Congestion", "Dg Health Cold and Flu Relief Nite Time", "DG Health cold and flu relief", "DG Health Triacting Childrens", "Night Time Original Pseudo-Free", "Childrens Plus Cough and Runny Nose", "Cough and Cold HBP", "Night Time Original Pseudo-Free", "Tussin Sugar Free Cough", "Vicks DayQuil Mucus Control DM", "CareOne Childrens Mucus Relief", "Humana Pharmacy Tussin Multi Symptom Cold", "Childrens Tukol Multi-Symptom Cold and Flu", "Next Night Severe Cold, Flu and Sore Throat", "Tussin DM", "Childrens Cough Mucus Relief", "Tukol MAX ACTION Cold, Sore Throat and Cough", "Tukol MAX ACTION Severe Congestion and Cough", "Multi Symptom Cold Plus Childrens Pain Relief", "Night Time Cough", "Nighttime Cold and Flu", "Night Time", "Mucus Relief Severe Congestion and Cold", "Plus Multi Symptom Cold Childrens Pain Relief", "Nighttime Cold and Flu", "Daytime Nighttime", "Daytime Nighttime", "Day Time with PE", "M-end DM", "Tussin CF Dextromethorphan HBr, Guaifenesin, Phenylephrine HCL", "Cold and Flu Relief Daytime Multi Symptom", "Flu and Severe Cold and Cough Daytime", "Adult Tussin DM Max", "Cold and Cough Daytime", "Cough and Sore Throat Daytime", "Cold Relief", "Cold Relief", "Tussin DM", "Dayrelief PE", "Nighttime Cold", "Mucus Relief Severe Congestion and Cold", "Tussin CF Adult Non Drowsy", "Night Relief Free", "Nite Time", "Night Relief Free", "DayRelief NON DROWSY MULTI SYMPTOM COLD FLU", "Day Relief PE", "Careone Severe Sinus Congestion", "Cold Relief", "Cold Relief", "Tussin Adult", "Multi Symptom Cold Plus Childrens", "DayQuil Cold and Flu", "Childrens Cough Plus Sore Throat", "Q Tussin DM", "Cold Relief Daytime", "DayTime Severe Cold and Flu Relief", "Cold Daytime", "Expectorant Cough Childrens", "Nitetime", "Cold Multi Symptom", "NightRelief Free Multi symptom cold flu", "Severe Cold Daytime Cold and Flu Nighttime", "Day Relief", "Cold Relief", "Cold Relief", "Night Relief Cough", "Night Relief", "Night Relief Multi Symptom Cold and Flu", "Cold Relief Non Drowsy", "Acetaminophen Dextromethorphan HBr Doxylamine succinate Phenylephrine HCl", "Nitetime Severe Cold and Flu Relief", "Cold Relief", "Childrens Mucus Relief Multi Symptom Cold", "Daytime PE Non Drowsy", "Sunmark Day Time Cold and Cough Childrens Triacting Formula", "Mucus Relief Severe Cold", "Cold Relief", "Cold Relief", "Alka-Seltzer Plus Flu Formula", "Childrens TYLENOL COLD plus COUGH plus RUNNY NOSE", "Nite Time multi symptom cold flu relief", "Nite Time MULTI SYMPTOM COLD FLU RELIEF", "Alka-Seltzer Plus Severe Sinus Congestion and Cough Day and Night", "Alka-Seltzer Plus Severe Sinus Congestion and Cough Day and Night", "Alka-Seltzer Plus Max Cough, Mucus and Congestion", "Day Time with PE", "Tussin CF", "Tussin Sugar Free Cough", "Childrens Plus Cough and Runny Nose", "Night Time Cherry Pseudo-Free", "Night Time Original Pseudo-Free", "Day Time with PE", "Daytime", "Childrens Wal Tap DM", "Nighttime Cold and Flu Relief", "Nighttime D Cold and Flu Relief", "Nighttime Cold and Flu Relief", "Good Sense Cold", "Cough and Cold HBP", "Nighttime Cold and Flu Relief", "Up and Up Cold and Flu Relief", "ShopRite Childrens Multi Symptom Cold Relief", "Neo DM", "Daytime Cold and Flu Relief Non Drowsy", "Daytime Cold and Flu Relief Non Drowsy", "Acetaminophen Dextromethorphan HBr Doxylamine succinate Phenylephrine HCl", "Good Sense Cold", "Good Sense Night Time", "Equate Nitetime Cold and Flu", "Sinus PE Pressure, Pain plus Cough Multi-Symptom", "Good Sense Cold", "Kirkland Signature Cold", "Good Sense Cough and Sore Throat Daytime Non Drowsy", "Good Sense Cold Head Congestion", "Triaminic Day Time Cold and Cough", "Tylenol Cold Multi-symptom", "TYLENOL Cold Multi-Symptom Severe", "Walgreens Adult Nighttime Wal Tussin DM Max Maximum Strength", "Mucus Relief DM Max Maximum Strength", "Mucus Relief Cold, Flu and Sore Throat Maximum Strength", "Mucus Relief DM", "Tussin DM", "Care One Cold Multi Symptom", "Care One Cold Multi Symptom", "Care One Cold Head Congestion", "Care One Cold Head Congestion daytime non-drowsy", "sunmark Cold", "Care One Cold Multi Symptom", "Donatussin", "Cold Relief Multi-Symptom", "Cold Relief Multi-Symptom", "ShopRite Ni Calm", "Smart Sense tussin dm max adult", "Cold Relief Head Congestion", "Smart Sense Adult Tussin DM sugar free", "Being Well Cold Flu Relief PM Multi Symptom", "Healthy Accents cold head congestion daytime non drowsy", "Nighttime multi symptom", "Sunmark nite time cold and flu", "Daytime", "Daytime Non Drowsy", "NIGHTTIME Multi Symptom", "Sunmark Nite Time Cough", "Day Time Night Time", "Day Time Night Time", "Sunmark Nite Time D Cold and Flu", "Rx Act Flu and severe cold and cough daytime", "Sunmark Cold Head Congestion", "Flu and Severe Cold and Cough Daytime", "Care One Cold Head Congestion", "Care One Cold Head Congestion", "Donatussin DM Drops DM", "Flu and Severe Cold and Cough daytime", "CareOne Adult Tussin DM", "Cold Relief Head Congestion Daytime Non-Drowsy", "Smart Sense Flu and Severe Cold and Cough Daytime", "Care One Flu and Severe Cold and Cough Daytime", "Night Time", "Daytime", "Guaifenesin and Dextromethorphan Hydrobromide", "Tussin CF", "Night Time Cherry Pseudo-Free", "Flu Relief Therapy Day Time", "Night Time Cherry Pseudo-Free", "Robafen DM Max Non drowsy", "Cold and Sinus PE Pressure, Pain and Cold Non-Drowsy", "Cough and Sinus PE Pressure, Pain and Cough Non-Drowsy", "Mucus Relief Maximum Strength", "Day Time", "Night Time Cold and Flu", "Being Well Cold and Flu Relief PM", "Allergy and Cough", "Equaline Nighttime", "Guaifenesin and Dextromethorphan Hydrobromide", "Equaline night time cough", "Equaline Tussin Cough and Cold", "Good Neighbor Pharmacy Cold", "Good Neighbor Pharmacy Cold", "Night Time Cold and Flu", "Topcare Cold Multi Symptom Severe", "Good Neighbor Pharmacy Cold Plus Multi Symptom", "PediaCare Childrens MultiSymptom Cold", "Good Neighbor Pharmacy Night Time", "Up and Up Cold Flu Relief Multi Symptom Day", "CareOne Mucus Relief Severe Congestion and Cold", "Good Neighbor Pharmacy Cold", "Good Neighbor Pharmacy Cold", "Equaline Nighttime Cold and Flu Relief", "Good Neighbor Pharmacy Cold Head Congestion", "Good Neighbor Pharmacy Night Time", "Up and Up Cold and Flu Relief", "Good Neighbor Pharmacy Night Time", "Good Neighbor Pharmacy Night Time D", "Equaline Childrens Cold", "Good Neighbor Pharmacy Night Time D", "Topcare Cold Head Congestion Severe", "Severe Cold", "Daytime Cold and Flu Relief", "Equaline Daytime Cold and Flu Relief", "Alka-Seltzer Plus Day and Night Cold", "Alka-Seltzer Plus Day and Night Cold", "Good Neighbor Pharmacy Cold Head Congestion", "Topcare Day Time Nite Time", "Topcare Day Time Nite Time", "Good Neighbor Pharmacy Childrens Pain Relief Plus Cough and Sore Throat", "Equaline Daytime and Nighttime Cold", "Equaline Daytime and Nighttime Cold", "Tussin DM", "Mucinex Fast-Max Severe Cold and Sinus", "Vicks NyQuil Cold and Flu Nighttime Relief", "Smart Sense Multi Symptom Cold", "Cold and Cough", "Night Time Cold and Flu Multi Symptom", "Mucus Relief cold flu and sore throat", "Rx Act Nighttime Cold Flu Relief Multi Symptom", "Equaline Nighttime Cold and Flu Relief", "Healthy Accents Mucus Relief Severe Congestion and Cold", "Smart Sense Childrens Multi Symptom Cold Relief", "Smart Sense NightTime Cold and Flu", "Daytime Non Drowsy", "Alka-Seltzer Plus Day Non-Drowsy Cold and Flu Formula", "Flu and Severe Cold and Cough Daytime", "Daytime Non Drowsy", "Rx Act Cough and Sore Throat", "Sunmark cold head congestion", "Nighttime Cold and Flu Relief", "Nighttime Cough", "Good Neighbor Pharmacy Cold Severe", "Mucus Relief Severe Congestion and Cold", "Cold and Cough", "Childrens Delsym Cough Plus Chest Congestion DM", "Night Time Cherry", "Night Time Cough Cherry", "Mucosa DM", "Mucus Relief", "Maximum Strength Daytime Cold/Flu Relief", "DayTime", "NiteTime", "Promethazine DM", "Vicks Formula 44 Cough and Head Congestion", "Adult Tussin Cough and Cold CF", "Alka-Seltzer Plus Cold and Cough Formula", "Nite Time Cold and Flu", "Stona for Children", "NIGHT-TIME MULTI-SYMPTOM COLD/FLU Original", "DAY-TIME Cold and Flu", "NIGHT-TIME MULTI-SYMPTOM COLD/FLU Cherry", "Triaminic Cough and Sore Throat", "Triaminic Day Time Cold and Cough", "Promethazine Hydrochloride and Dextromethophan Hydrobromide", "Childrens Plus Cough and Runny Nose", "Night Time Cherry Pseudo-Free", "Tussin DM", "Mucus Relief Cold, Flu and Sore Throat Maximum Strength", "CareOne Tussin DM cough plus chest congestion", "Mucus Relief Severe Congestion and Cough Maximum Strength", "CareOne Childrens Cold and Cough", "Childrens Multi Symptom Cold", "Cough Childrens", "All-Nite Cold and Flu", "Childrens Plus Multi-Symptom Cold Grape with PE", "Careone Cold Max", "Night Time Cherry Pseudo-Free", "Mucus Relief Cold, Flu and Sore Throat Maximum Strength", "Family Dollar Multi-Symptom Severe Cold Green Tea and Honey Lemon flavors", "Cough and Cold HBP", "Cough and Sore Throat Childrens Pain Relief", "Day Time Cold and Flu", "Cold", "Cold", "Cold", "Cold PE", "Multi-Symptom Cold Relief", "Multi-Symptom Cold Relief", "Tussin Cough DM Adult Sugar Free", "Cold Head Congestion", "Cold Head Congestion", "Nighttime D Cold and Flu", "Tussin Cough DM Adult", "Tussin CF", "De-Chlor DM", "Night Time Cold and Flu", "Pain Relief Cold", "Topcare Day Time Nite Time Cold and Flu Relief", "Topcare Day Time Nite Time Cold and Flu Relief", "Leader Tussin DM", "Little Colds Multi Symptom Cold", "Sound Body Tussin CF", "Day Time", "Alka-Seltzer Plus Day and Night Multi-Symptom Cold and Flu Formula", "Alka-Seltzer Plus Day and Night Multi-Symptom Cold and Flu Formula", "Nighttime Cold and Flu", "Smart Sense Nighttime", "Tussin CF Maximum Strength", "Alka-Seltzer Plus Severe Sinus Congestion and Cough Day and Night", "Alka-Seltzer Plus Severe Sinus Congestion and Cough Day and Night", "Alka-Seltzer Plus Severe Sinus Congestion and Cough Liquid Gels", "Alka-Seltzer Plus Severe Sinus Congestion, Allergy and Cough", "Alka-Seltzer Plus-D Multi-Symptom Sinus and Cold", "Alka-Seltzer Plus Multi-Smptom Cold and Flu Night", "Alka-Seltzer Plus Day and Night Cold and Flu Formula", "Alka-Seltzer Plus Day and Night Cold and Flu Formula", "Alka-Seltzer Plus Day and Night Cold and Flu Formula", "Alka-Seltzer Plus Day and Night Cold and Flu Formula", "Childrens Plus Cough and Sore Throat", "Cold and Flu Relief Nighttime, Multi-Symptom", "Good Neighbor Pharmacy Cold", "Childrens Plus Multi-Symptom with PE", "Night Time Cherry", "Night Time Cough", "Night Time Cherry", "Night Time Cough Cherry", "Pediacare Childrens Cough And Congestion", "Pediacare-Cough-RunnyNose", "PediaCare Multi Symptom Cold", "Up and Up mucus relief cold, flu and sore throat", "Nighttime D Cold and Flu Relief", "Alka-Seltzer Plus Day Severe Cold, Cough And Flu", "Equate Daytime Cold and Flu", "Nite Time Cold/Flu Relief", "Nite-TimeCOLD/FLU CHERRY COLD/FLU CHERRY", "Daytime Non-Drowsy COLD/FLU", "Tussin Cough Expectorant Cough Supressant DM", "Supress A", "Tusslin TR", "Leader Nite Time Multi Symptom Cold and Flu Relief", "Leader Cold Head Congestion", "Leader Cold Head Congestion", "Wal Tussin CF Max", "Leader nite time multi symptom cold flu relief", "Leader Nite Time", "Leader Day time Cough and Cold Childrens", "Tussin DM", "DayTime Cold and Flu", "Nitetime Cold and Flu", "Nitetime D multi symptom cold flu relief", "Topcare Day time cold and flu relief", "Daytime Nitetime", "Daytime Nitetime", "DayTime Cold and Flu", "Tussin Cough Adult Maximum Strength", "Topcare Nite Time Cold and Flu Relief Multi Symptom Relief", "Cough Tussin", "TopCare Nite Time", "Topcare Day Time Nite Time", "Topcare Day Time Nite Time", "Topcare Cold Head Congestion Nighttime", "Cold Relief Multi Symptom", "Topcare Cold and Cough", "Topcare Nite Time Multi Symptom Relief", "Adult CF Cough", "Nitetime D", "Cough", "Head Congestion", "Head Congestion", "Cough Syrup", "Topcare Cough and Sore Throat", "TopCare Cold NightTime Multi Symptom", "Top Care Day Time Multi Symptom Relief", "Nite Time Cold and Flu", "Topcare Cold Head Congestion", "Topcare Nite Time D", "Topcare DayTime", "Topcare Nite Time Cold and Flu", "Cold Relief", "Cold Relief Head Congestion", "Sun Mark Tussin DM cough and chest congestion", "Cold Relief", "Cold Relief", "Cold, Flu and Sore Throat Maxium Strength", "Zicam", "Mucus Relief Maximum Strength", "Zicam", "CareOne Tussin DM Nighttime Cough", "Mucinex Fast-Max Day Severe Congestion and Cough and Night Cold and Flu", "Mucinex Fast-Max Day Severe Congestion and Cough and Night Cold and Flu", "Mucinex Fast-Max Severe Congestion and Cough", "Mucinex Fast-Max Day Severe Cold and Night Cold and Flu", "Mucinex Fast-Max Day Severe Cold and Night Cold and Flu", "Bromfed DM", "PediaCare Childrens Plus Flu", "PediaCare Childrens Plus Multisymptom Cold", "Healthy Accents Cold and Cough", "Healthy Accents Cold Head Congestion", "Smart Sense Nighttime", "Cold Relief", "Cold Relief", "Healthy Accents Cold", "Healthy Accents Cold", "Healthy Accents Cough and Sore Throat Night Time", "Smart Sense Tussin DM", "Healthy Accents Cold Head Congestion", "Healthy Accents Daytime Cold and Flu", "Healthy Accents Nighttime Cold and Flu", "Healthy Accents Nighttime Cold and Flu", "Smart Sense Adults Tussin CF Multi Symptom Cold", "Berkley and Jensen Adult Tussin DM", "Healthy Accents nighttime cold and flu", "Smart Sense Tussin CF Adult", "Rx Act Cold Head Congestion", "Alka-Seltzer Plus Severe Sinus Congestion and Cough", "Alka-Seltzer Plus Cold and Cough Formula", "Childrens Mucus Relief Cherry", "Night Time Cherry Pseudo-Free", "Night Time Original Pseudo-Free", "Tussin CF", "Flu Relief Therapy Day Time", "Night Time Original Pseudo-Free", "Day Time with PE", "Flu Relief Therapy Day Time", "Flu Relief Therapy Day Time", "Childrens Relief Cherry", "Allpanto S", "Childrens Mucus Relief", "Triacting Day Time with PE", "Flu Relief Therapy Day Time", "CareOne Tussin CF Multi Symptom Cold", "NEXT COLD and FLU DAYTIME", "NEXT COLD and FLU NIGHTTIME", "Alka-Seltzer Plus Cold and Cough", "Childrens TYLENOL COLD PLUS COUGH PLUS SORE THROAT", "Childrens TYLENOL COLD Plus FLU", "Neo DM DROPS DM", "Day Time Night Time Cold and Flu", "Day Time Night Time Cold and Flu", "Nitetime Cold and Flu", "Guaifenesin and Dextromethorphan Hydrobromide", "Mucus Relief Cough and Congestion DM", "Nighttime Cold and Flu", "Rapid Max Maximum Strength Cool and Clear - Cold, Flu and Sore throat", "Childrens Tussin DM", "Rapid Max Maximum Strength Cool and Clear - Cold, Severe Congestion and Cough", "Vicks Formula 44 Cough and Chest Congestion", "Mucinex DM", "NightTime Cold and Flu", "Despec DM", "Daytime Cold and Flu Lil Drug Store Products", "Adult Tussin DM Lil Drug Store Products", "Maxi-Tuss DM", "Maxichlor PEH DM", "Cough and Cold HBP", "Circle K Daytime Cold and Flu", "Tusnel Pediatric", "Altipres Pediatric", "Bio-rytuss", "Biodesp DM NF", "Altipres", "Biocof", "Tusnel", "Lortuss DM", "Siltussin DM", "Topcare Mucus Relief", "Alahist DM", "Deconex DM", "Mucinex Fast-Max Cold, Flu and Sore Throat", "Daytime Severe Cold and Cough and Nighttime Severe Cold and Cough", "DoloMax Cold Cough", "Up and Up Childrens Multi Symptom Cold Pain Relief Plus", "PediaCare Plus Multisymptom Cold", "Multi Symptom Daytime", "TopCare Chest Congestion and Cough Relief DM", "Alka-Seltzer Plus Night Cold and Flu Formula", "Brotapp DM Cold and Cough", "Alka-Seltzer Plus Severe Cold, Mucus and Congestion", "Topcare Cough Cold and Flu Simple Relief", "Wal Tussin DM", "Cough Relief Nighttime", "topcare tussin CF", "sanaflu Night-Time Xtreme Multi-Symptom Cold/Flu Relief Cherry Flavor", "Dg Health Cold Head Congestion Severe Day Time", "Wal-Phed PE Pressure plus Pain plus Cold Daytime, Nighttime, Multi-Symptom", "Cough and Cold HBP", "Topcare Tussin DM", "Niva-Hist DM", "Diabetic Maximum Strength Siltussin DM DAS-Na", "Good Neighbor Pharmacy Tussin DM Max", "Daytime Cold and Flu Relief", "Multi Symptom Cold", "Good Neighbor Pharmacy Multi Symptom", "Cold Relief Severe", "Good Sense cold multi symptom", "Cold and Cough", "Topcare Cold and Cough", "Cough and Sore Throat Pain Relief", "Topcare Cough and Sore Throat", "Good Neighbor Pharmacy Cough and Sore Throat", "Cough and Sore Throat Multi Symptom", "Night Time", "Cough Syrup", "Severe Cold Multi Symptom", "Nighttime Cold and Flu Relief", "Rx Act Cough and Sore Throat", "Tussin", "Cold Relief Multi Symptom", "Leader Tussin", "Leader Nite Time", "Cold and Cough", "Rx Act Tussin CF Cough and Cold", "Brotapp PE-DM Cough and Cold", "Topcare Tussin DM Max", "Brompheniramine Maleate, Pseudoephedrine Hydrochloride, and Dextromethorphan Hydrobromide", "Alka-Seltzer Plus Severe Cold And Flu Formula", "Topcare Cold", "Daytime Nighttime Multi Symptom Cold Flu Relief", "Daytime Nighttime Multi Symptom Cold Flu Relief", "Leader Mucus Relief Severe Congestion and Cold", "TopCare Cold Max", "Equate Childrens Cold and Cough", "Nite-Time COLD/FLU Medicine Cherry", "Nite-Time COLD/FLU Medicine", "Diabetic Tussin DM", "Deconex Dmx", "Cold Multi Symptom Severe", "Topcare Nite Time Cold and Flu", "Severe Sinus Congestion", "Night Time Cold and Flu", "cold and cough sinus relief PE NON-DROWSY", "Pediatric Cough and Cold Medicine", "Equaline Cold and Flu Relief", "Equaline Cold and Flu Relief", "Good Sense Tussin CF Cough and Cold", "Wal Tussin CF Cough and Cold", "Rexall Daytime Nighttime Cold and Flu", "Rexall Daytime Nighttime Cold and Flu", "End-A-flu Multi-symptom Severe Cold and Cough Non Drowsy Daytime Formula", "FLU-MED DAYTIME SEVERE COLD and COUGH non drowsy formula", "Cold and Cough", "Cold and Cough", "Cough and Cold HBP", "Diabetic Siltussin DM DAS-Na", "Cold and Cough MULTI-SYMPTOM DAYTIME / NIGHTTIME", "Tukol A", "Childrens TYLENOL COLD Plus FLU", "Contac Cold and Flu Cooling Relief", "Care One cold head congestion", "CareOne Mucus Relief", "CareOne Nitetime Severe Cold Flu Relief", "Cold and Cough", "Nighttime Cold and Flu Relief", "CareOne Mucus Relief", "Multi Symptom Cold CF", "Cepacol Sore Throat Plus Cough", "Cold and Flu Relief Daytime", "Triaminic Day Time Cold and Cough and Night Time Cold and Cough", "Rexall Night Time Cold and Flu", "Day Time Non-Drowsy Cold - Flu Relief", "DG Health Pain Relief Cold Night Time", "DG Health cold multi symptom severe", "Dg Health Mucus Relief", "NightRelief DayRelief", "NightRelief DayRelief", "Dg Health Cough and Sore Throat Nite Time", "Cough and Cold HBP", "Wal Flu Severe Cold and Cough Daytime", "Cold and Cough High Blood Pressure", "Topcare childrens cold and cough", "Cold and Cough", "Nite Time Cold Medicine", "Cough Formula Cough and Cold", "Brom Tapp DM", "Ritussin DM", "Nite Time Cold Medicine Cherry Flavor", "Mucus DM Extended Release", "Careone Childrens Mucus Relief", "Leader Mucus DM", "Topcare mucus relief", "Biodesp DM", "Tussin DM", "BioGtuss NF", "Pentrexcilina", "Altipres-B", "Bio-S-Pres DX", "Altituss", "Triponel", "Topcare mucus relief cold flu and sore throat", "Cough and Cold", "Topcare Childrens Mucus Relief Multi Symptom Cold", "Promethazine DM", "BC Daytime Multi-Symptom", "Alka-Seltzer Plus Night Cold and Flu Formula", "Childrens Pain Relief Plus Multi Symptom Cold", "Cough and Cold HBP", "Vicks DayQuil Cough", "Igualtuss", "Severe Cough and Congestion", "Severe Congestion and Cough/Cold and Flu Daytime/Nighttime/Maximum Strength", "Sudafed PE Pressure Plus Pain Plus Cough Day", "Good Sense Mucus DM", "Mucus Relief DM", "ALKA SELTZER PLUS Cold Day and Night Effervescent", "Tussin CF Cough and Cold", "Adults Tussin DM", "Guaifenesin and Dextromethorphan", "Guaifenesin and Dextromethorphan", "DG health mucus dm", "Bionatuss DXP", "Cough and Cold HBP", "DayQuil Severe plus Vicks VapoCool", "Vicks Formula 44 VapoCool Severe Nighttime Cough and Cold", "Sinex Severe plus Vicks VapoCool", "Marcs Chest Congestion Relief DM", "Dibromm DM", "Alka-Seltzer Plus Multi-Symptom Cold and Flu Day Liquid Gels", "Childrens Cough", "Robafen CF Cough and cold", "Childrens Multi-symptom Cold", "Childrens Multi-symptom Cold and Fever Liquid", "Alka-Seltzer Plus Severe Sinus Congestion and Cough Liquid Gels Day", "Alka-Seltzer Plus Severe Sinus Congestion and Cough Liquid Gels Night", "CareOne Childrens Cold and Flu", "Exchange Select Mucus DM", "Good Neighbor Pharmacy Tussin DM MAX Nighttime Cough", "Night Time Original Pseudo-Free", "Topcare Daytime Nitetime Multi Symptom Relief", "Topcare Daytime Nitetime Multi Symptom Relief", "Tylenol Cold Plus Flu Severe Severe", "Mucus DM", "Promethazine DM", "Mucus Relief Complete", "Mucus Relief Cough", "Multi-Symptom Cold Relief", "Multi-Symptom Cold Relief", "Next Day Time Non drowsy Cold and Flue", "Daytime Cold and Flu Relief", "Nighttime Cold and Flu Relief", "Aurotussin Peak Cold Maximum Strength Cough plus Chest Congestion DM", "Next Night Time Cold and Flu Relief", "Premier Value Multi-Symptom Severe Cold Green Tea and Honey Lemon flavors", "Mucus Relief Severe Congestion and Cough Maximum Strength", "CareOne Nighttime Severe Cold and Flu", "Topcare Mucus DM", "Robafen", "Rugby Cough", "Mucinex Fast-Max Severe Congestion and Cough", "Nighttime Severe Cold and Flu", "NightTime Severe Cold and Flu", "Severe Cough and Congestion", "MAX Cold, Flu, and Sore Throat", "Good Neighbor Pharmacy Night Time Severe", "Day-Time NON-DROWSY COLD/FLU RELIEF", "Severe Cold and Flu", "Original Night-Time MULTI-SYMPTOM COLD/FLU RELIEF", "Night-Time Multi-Symptom Cold/Flu Relief", "Alka-Seltzer Plus Multi-Symptom Cold and Cough", "Up and Up Maximum Strength Mucus Relief DM", "Alka-Seltzer Plus Multi-Symptom Cold Night", "Scot-Tussin Senior Maximum Strength Cough Suppressant and Expectorant", "Signature Care Nighttime Severe Cold and Flu Relief", "Scot-Tussin DM Maximum Strength Cough Suppressant and Cold Relief", "Careone Childrens Multi Symptom Fever and Cold", "Nitetime Cold and Flu", "Theraflu Daytime Severe Cold and Cough", "Nighttime severe", "Cold Multi-Symptom", "Cold Multi-Symptom", "Dg Health Cold and Flu", "Despec EDA Drops", "Tussin CF", "Equaline Nighttime Severe Cold and Flu", "Tussin DM", "Despec", "Sore throat and cough lozenge", "Severe Cold and Flu", "Day Time Nighttime Cough", "Day Time Nighttime Cough", "Good Neighbor Pharmacy Tussin DM Max", "Extra action Cough", "Cough and Sore Throat Childrens", "Promethazine DM", "Nighttime Cough Relief Cherry", "XL-3 Day Time", "XL-3 Day Time", "Cold and Flu Night-time Multi Symptom Relief Cherry", "Cold and Flu Night Time Multi-Symptom Relief Original", "XL-3 Xtreme", "XL-3 Xtreme", "Cold and Flu Day Time Multi-Symptom Relief", "Nitetime", "Nighttime", "Day Time Non Drowsy", "Signature Care Non drowsy Daytime Severe Cold and Flu Relief", "Dg Health Cold and Flu Severe", "Cold Preparation For Cough and Sinus Relief", "Cold Preparation", "Nitetime cold and flu relief", "DayTime Nitetime cold and flu relief", "DayTime Nitetime cold and flu relief", "Daytime Cough Nighttime Cough", "Daytime Cough Nighttime Cough", "Tussin DM Max Daytime Nighttime", "Tussin DM Max Daytime Nighttime", "Tussin Maximum Strength", "Good Neighbor Pharmacy Tussin CF Max", "Rexall Daytime Nighttime Cold Flu", "Rexall Daytime Nighttime Cold Flu", "TopCare Day Time Nite Time Cold and Flu Relief", "TopCare Day Time Nite Time Cold and Flu Relief", "Guaifenesin and Dextromethorphan Hydrobromide", "Tylenol Cold Max Night", "TYLENOL Cold Plus Mucus Severe", "DS Never Cold S", "Tussin DM", "Topcare Nite Time Cold and Flu", "Tussin DM", "Guaifenesin and Dextromethorphan Hydrobromide", "Multi Symptom Cold", "Cough and Chest Congestion", "DAYTIME NIGHTTIME Cold and Flu", "DAYTIME NIGHTTIME Cold and Flu", "Vicks DayQuil Severe Cold and Flu", "Wal Tussin DM Max", "Cough and Chest Congestion", "Careone Tussin DM", "Nitetime Cold and Flu", "Severe Cold and Flu", "Cough Day Night", "Cough Day Night", "Severe Cold Cough and Flu", "TYLENOL Cold plus Flu plus Cough Day", "Adult DM Max Cough and Chest Congestion", "Childrens mucus relief", "Bactimicina Cough and Cold", "Brompheniramine Maleate, Pseudoephedrine Hydrochloride and Dextromethorphan Hydrobromide", "Bactimicina Childrens Cough and Cold", "Mucinex Sinus-Max Pressure, Pain and Cough", "Nitetime Cold and Flu", "Severe Nighttime", "DG Health adult tussin multi symptom cold", "Tussin Nighttime Cough Control", "NItetime cough", "Harris Teeter DayTime NightTime", "Harris Teeter DayTime NightTime", "Equate Nitetime Severe", "Nighttime cold and flu", "Severe Cold and Flu", "Careone daytime severe cold and flu", "Nighttime Cough", "Severe Daytime", "Daytime Severe Cold and Flu", "Day Night Cold and Flu", "Day Night Cold and Flu", "Up and Up severe cold and flu daytime", "Equate DayTime Severe", "Daytime Nighttime", "Daytime Nighttime", "Equate DayTime NiteTime", "Equate DayTime NiteTime", "Cold and Flu Multi-Symptom Nighttime Severe", "Rabofen DM", "Facol Cold and Flu Day and Night", "Facol Cold and Flu Day", "Theraflu ExpressMax Daytime Severe Cold and Cough", "Facol Cold and Flu Night", "Daytime Cold and Flu", "Daytime cold and flu non drowsy", "Robafen DM", "Nitetime cold and flu relief", "Childrens Plus Cough and Runny Nose", "Daytime Cold and Flu Relief", "Daytime Cold and Flu Relief Non Drowsy", "NightTime Cough", "Daytime Nighttime Cold Flu Relief", "Daytime Nighttime Cold Flu Relief", "Nighttime Cold and Flu Relief", "DayTime Nighttime", "DayTime Nighttime", "Multi symptom Nighttime cold and flu relief", "Mucinex Childrens Cough", "Daytime Fast Severe Cold Relief Nitetime Fast Cold and Flu Relief", "Daytime Fast Severe Cold Relief Nitetime Fast Cold and Flu Relief", "Mucinex Childrens Multi-Symptom Cold and Sore Throat", "Delsym Cough Plus Cold Day Time", "Nighttime", "Nighttime Severe Cold and Flu Relief", "Night Time Cherry", "Mucinex Childrens Multi-Symptom Cough, Cold and Fever", "Nighttime Cold and Flu Relief", "Fast Cold and Flu Relief", "Daytime Cold and Flu", "Nighttime Cold and Flu Relief", "Daytime Nighttime Severe Cold and Flu Relief", "Daytime Nighttime Severe Cold and Flu Relief", "Neogen-D", "Cold and Flu", "Childrens Wal Tap DM Cough and Cold", "Tussin Sugar Free", "Cold and Flu", "Tussin DM COUGH SUPPRESSANT/EXPECTORANT", "Fast Cold and Flu Relief", "Pentrexcilina", "Daytime PE", "Cold and Cough DM", "Daytime Nighttime Cold Flu Relief", "Daytime Nighttime Cold Flu Relief", "Equate Nitetime", "Equate NiteTime DayTime", "Equate NiteTime DayTime", "TopCare Tussin DM Nighttime Cough", "Leader Severe Cold and Flu", "Nighttime Cold Flu Relief", "Mucinex Fast-Max Severe Cold", "Alka-Seltzer Plus Maximum Strength Cold and Cough Liquid Gels with Cool Menthol Flavor Liquid Gels", "Mucinex Fast-Max Day Time Cold and Flu and Night Time Cold and Flu", "Cold and Flu", "Good Neighbor Pharmacy Night Time", "Mucus Relief DM Immediate Release", "Equate Nite Time Cough", "Leader Nite Time", "Leader Tussin CF", "Good Neighbor Pharmacy Night Time Cold and Flu", "Good Neighbor Pharmacy Severe Sinus Congestion", "Mucinex Fast-Max Severe Congestion and Cough", "Leader Day Time", "Leader Adult Tussin DM", "Equate Nitetime", "Good Neighbor Pharmacy night time cough", "Leader Nite Time", "Nighttime Cough Relief", "Childrens Flu Relief", "Abatuss Dmx", "Good Neighbor Pharmacy Night Time", "Daytime Cold and Flu Relief", "Severe Cold and Flu Relief", "Cold and Flu", "Equaline Nighttime Cough Relief", "Delsym Cough Plus Cold Day Time", "Equaline Daytime Severe Cold Fast Relief Nighttime Cold and Flu Fast Relief", "Equaline Daytime Severe Cold Fast Relief Nighttime Cold and Flu Fast Relief", "Childrens Cold and Cough", "Equaline Nighttime Cold and Flu Relief", "Equaline Nighttime Cold and Flu Relief", "Equaline Daytime and Nighttime Cold and Flu Relief", "Equaline Daytime and Nighttime Cold and Flu Relief", "Equaline nighttime cold and flu relief", "Mucinex Fast-Max Day Time Severe Cold and Mucinex Fast-Max Night Time Cold and Flu Maximum Strength", "Cold Multi Symptom", "Equaline mucus relief", "Childrens Mucinex Congestion and Cough", "Equaline Childrens Cold and Cough", "Multi Symptom Cold CF", "PECGEN PSE Cough Suppressant Expectorant Nasal Decongestant GRAPE Flavor", "Supress DM", "Guaifenesin and Dextromethorphan Hydrobromide", "Mucinex Fast-Max Severe Congestion and Cough Clear and Cool and Mucinex Fast-Max Night Time Cold and Flu Clear and Cool", "Day time cold and flu", "Flu Relief Therapy Daytime", "Daytime Non Drowsy", "Leader Mucus Relief", "ShopRite Ni Calm", "Leader Childrens Mucus Relief Multi Symptom Cold", "Leader Tussin DM", "Childrens Plus Multi Symptom Cold Dye Free", "Being Well Night Time Cold and Flu", "ShopRite Ni Calm", "Adult Tussin Cough and Chest Congestion DM Sugar Free", "ShopRite Ni Calm Cough", "ShopRite Ni Calm", "Rexall DM Cough and Congestion Relief", "Childrens Mucinex Multi Symptom Cold and Childrens Mucinex Night Time Multi Symptom Cold", "Tussi Pres Pediatric", "ShopRite Childrens Cold and Cough", "ShopRite Day Calm", "Cold and Flu", "Nighttime Severe", "Multi Symptom Cold Relief Childrens", "Mucus Relief Cold, Flu and Sore Throat Maximum Strength", "Nighttime", "Day Time Cold Flu Relief", "Daytime Nighttime Multi Symptom Cold and Flu Relief", "Daytime Nighttime Multi Symptom Cold and Flu Relief", "Cold", "Harris Teeter NightTime", "Harris Teeter DayTime NightTime", "Harris Teeter DayTime NightTime", "Cough and Sore Throat Childrens", "Severe Cold and Flu", "Daytime Nighttime cold and flu relief", "Daytime Nighttime cold and flu relief", "Harris Teeter NightTime", "Severe Daytime", "Triacting Day Time Cold and Cough Childrens", "Cold and Flu Plus", "Cold and Flu Plus", "Nighttime Cold and Flu Relief", "Severe Cold and Cough Relief Daytime", "Cold and Cough childrens", "Nighttime Cold Multi-Symptom Cool Blast", "Preferred Plus Severe Nite Time", "Brompheniramine Maleate, Pseudoephedrine Hydrochloride, and Dextromethorphan Hydrobromide", "Sanaflu Xtra", "Actinel Pediatric", "Up and Up Nighttime Cold and Flu", "Mucinex Fast-Max Day Time Severe Congestion and Cough and Mucinex Fast-Max Night Time Cold and Flu Maximum Strength", "Up and Up Nighttime Cold and Flu", "Up and Up Cold Flu Relief", "Up and Up nighttime cough control", "Up and Up Daytime Nighttime Cold and Flu", "Up and Up Daytime Nighttime Cold and Flu", "Actinel", "Mucosa DM", "Sorbugen", "Supress DX Pediatric Drops", "Careone Day Severe Cold Night Cold and Flu", "Careone Day Severe Cold Night Cold and Flu", "Dimaphen DM", "Healthy Accents Mucus Relief Severe Cold", "Healthy Accents Cold and Flu", "DG Health Mucus Relief", "NiteTime Cold Flu Relief", "All Nite", "Healthy Accents Nighttime Cold and Flu", "Healthy Accents Childrens Cold and Cough", "Healthy Accents Nighttime Cold and Flu", "Healthy Accents Childrens Multi Symptom Fever and Cold", "Healthy Accents Daytime Nighttime Cold and Flu", "Healthy Accents Daytime Nighttime Cold and Flu", "Healthy Accents Daytime", "DG Health Fast Acting Mucus Relief Severe Cold", "Robafen DM", "DG Health Cold Max", "Dg Health Cold and Flu Relief", "DG Health Tussin", "Mucinex Fast Max Day Time Severe Congestion and Cough and Night Time Cold and Flu", "Sorbutuss NR", "Dg Health Cough Night Time", "DG Health Childrens Cold and Cough", "Night time multi symptom cold/flu relief", "Comtrex Cough and Cold Day/Night", "Comtrex Cough and Cold Day/Night", "Mucus Relief Maximum Strength DM Max", "Daytime Cold Flu multi Symptom", "Day Time Cold and Flu Relief", "Multi- Symptom Relief DayTime", "Nite-Time Cold and Flu Multi-Symptom Relief", "Dg Health Cold and Flu Relief", "Mucinex Fast-Max Day Time Severe Congestion and Cough and Mucinex Fast-Max Night Time Cold and Flu Maximum Strength", "Severe Cold and Cough Relief Daytime", "Day Time Cold and Flu Multi-Symptom Relief", "Non Drowsy Day Time cold and Flu Relief", "Night Time Caps Cold Flu Multi symptom", "Mucus Relief DM", "Healthy Accents Nighttime Cold and Flu", "Biospec DMX", "BioTPres Pediatric", "BIO Dtuss DMX", "Good Sense tussin dm max", "Biocotron-D", "BioGtuss", "Healthy Accents Daytime Nighttime Cold and Flu", "Healthy Accents Daytime Nighttime Cold and Flu", "Signature Care Childrens Cold and Cough", "Bio-B Kids", "BioTPres", "Tusnel", "Healthy Accents Mucus Relief cold flu and sore throat", "Biobron DX", "Tusnel DM Pediatric", "Multi-Symptom Nitetime", "Cold and Flu Relief Nighttime Multi Symptom", "Day time cold and flu", "Good Sense Cold and Flu Severe", "Tusicof", "Smart Sense NightTime DayTime", "Smart Sense NightTime DayTime", "Quality Choice Multi-Symptom, Non-Drowsy DayTime Cold and Flu", "Smart Sense Multi Symptom Fever and Cold Childrens", "Good Sense Nighttime Cough", "Quality Choice Nighttime Cold and Flu", "Smart Sense Cold and Cough", "Daytime Nighttime Cold Flu Relief", "Daytime Nighttime Cold Flu Relief", "Cold and Flu Nighttime Multi Symptom", "Tussi Pres", "G-Supress DX", "Severe Cold and Cough Relief Daytime", "Good Sense Nighttime", "Daytime Cold and Flu Relief", "Smart Sense Nighttime", "Actidom Dmx", "Safeway Nighttime Cold and Flu", "Childrens Multi-Symptom Cold Plus Dye-Free", "Good Sense Childrens Cold and Cough", "Presgen Pediatric", "Nighttime Cold and Flu Relief", "Smart Sense Nighttime Cough", "Good Sense NightTime DayTime Cold and Flu", "Good Sense NightTime DayTime Cold and Flu", "Nite time cold and flu relief", "Day Time PE cold and flu relief", "Mucus and Cough Relief", "Good Sense Night Time", "Cough", "Expectorant Tab DM", "Day Time Cold and Flu", "DayRelief Multi symptom", "Healthy Accents Multi Symptom Cold", "Good Sense Severe NightTime", "Smart Sense Nighttime", "Cold Relief Multi-Symptom", "Cold Relief Multi-Symptom", "Tussin CF", "Pressure Plus Pain PE Plus Cold", "Tussin DM Adult", "MAXIUM STRENGTH SEVERE CONGESTION and COUGH MAX", "Mucus Relief Severe Congestion and Cough Maximum Strength", "Cold and Flu Severe", "Topcare Nite Time Cold and Flu", "Tussin CF Adult", "Smart Sense Daytime Nighttime Cold and Flu", "Smart Sense Daytime Nighttime Cold and Flu", "Childrens Plus Flu", "Night-Time COUGH RELIEF", "Cold Head Congestion Daytime", "Cold Multi-Symptom Daytime", "Severe Cold and Flu", "Maxium Strength DM Max", "Mucus Relief Day Time and Night Time", "Mucus Relief Cold, Flu and Sore Throat", "Severe Cold and Flu Relief", "Mucus Relief Severe Cold", "Daytime Multi-symptom Cold Relief", "Leader Nighttime Sever Cold and Flu", "Cough and Sore Throat Childrens Plus", "Pressure and Pain PE plus Cough", "Pressure and Pain PE Plus Cold", "TopCare Pain Relief Cold Nightttime", "Tussin CF", "Mucus Relief Cold, Flu, Sore Throat Maximum Strength", "Mucus Relief DM", "Daytime Nighttime Cold Flu Relief", "Daytime Nighttime Cold Flu Relief", "Careone Daytime Nighttime Severe Cold and Flu", "Careone Daytime Nighttime Severe Cold and Flu", "Topcare Day Time", "NightTime DayTime Severe Cold and Flu", "NightTime DayTime Severe Cold and Flu", "Day Time Night Time Severe Cold and Flu", "Day Time Night Time Severe Cold and Flu", "Severe Nighttime Severe Daytime", "Severe Nighttime Severe Daytime", "Signature Care daytime nighttime severe cold and flu relief", "Signature Care daytime nighttime severe cold and flu relief", "Severe Cold and Flu", "Severe Cold and Flu", "NiteTime DayTime Cold and Flu", "NiteTime DayTime Cold and Flu", "Up and Up severe cold and flu", "Up and Up severe cold and flu", "Theraflu PowerPods Daytime Severe Cold", "Nitetime Cold and Flu", "Guaifenesin and Dextromethorphan HBr", "Care One Chest Congestion Relief DM", "Wal Tussin DM Max Nighttime Wal Tussin DM Max", "Wal Tussin DM Max Nighttime Wal Tussin DM Max", "Cough and Cold", "Mucinex Childrens Multi-Symptom Cold", "Pedia Relief", "Equate DayTime NiteTime Severe", "Equate DayTime NiteTime Severe", "Childrens Dimetapp Cold and Cough", "Tylo Cold and Flu Night", "Biocotron", "Childrens Multi Symptom Cold", "Tylo Cold and Flu Day", "Cold and Cough", "Adult Tussin Cough and Chest Congestion DM Sugar Free", "Tussin Nighttime Cough DM Maximum Strength", "Bromfed DM", "Dextromethorphan Hydrobromide and Promethazine Hydrochloride", "Quality Choice Mucus Relief DM DM", "Robitussin Maximum Strength Nighttime Cough DM", "Mucus Relief DM Extended Release Caplets", "Night Time Cold and Flu Relief Multi Symptom", "Mucus Relief DM", "Basic Care Nighttime Cold and Flu", "Shoprite Ni Calm", "Mucus Relief DM Extended Release Caplets", "Mucus Relief Severe Congestion and Cough Maximum Strength", "Mucus Relief Cold Flu and Sore Throat Maximum Strength", "Daytime Nitetime Cold and Flu", "Daytime Nitetime Cold and Flu", "Mucus Relief DM Maximum Strength", "Nitetime Cough", "Childrens Cough and Cold", "Daytime Cough", "Robitussin Peak Cold Cough Plus Chest Congestion DM", "Robitussin Peak Cold Sugar-Free Cough Plus Chest Congestion DM", "Congestion and Headache", "Daytime Mucus Relief Severe Cold and Nighttime Cold and Flu Maximum Strength", "Daytime Mucus Relief Severe Cold and Nighttime Cold and Flu Maximum Strength", "Basic Care Mucus Relief Severe Congestion and Cough", "Robitussin Severe Multi-Symptom Cough Cold Flu", "Cold Flu and Sore Throat", "Robitussin Maximum Strength Severe Cough Plus Sore Throat", "Mucus Relief Cold Flu Sore Throat Maximum Strength", "Mucus Relief Severe Sinus Congestion", "Good Neighbor Pharmacy Mucus Relief DM", "Good Neighbor Pharmacy Tab Tussin DM DMTDM", "Daytime Nighttime Sinus Relief Maximum Strength", "Daytime Nighttime Sinus Relief Maximum Strength", "EQUATE Tussin DM Max Daytime Nighttime", "EQUATE Tussin DM Max Daytime Nighttime", "Daytime Mucus Relief Severe Cold Nighttime Cold and Flu Maximum Strength", "Daytime Mucus Relief Severe Cold Nighttime Cold and Flu Maximum Strength", "DayTime Cold and Flu Non Drowsy", "Daytime PE Nitetime", "Daytime PE Nitetime", "Pressure Pain Cold PE", "CVS Chest Congestion Relief DM", "Leader Cold and Flu", "Leader Cold Relief", "Leader Nighttime Cold and Flu", "Leader Mucus Relief Cold Flu and Sore Throat", "Leader Nighttime Cold and Flu", "Leader Nighttime Cough", "Leader severe cold and flu", "Leader Childrens Cold and Cough", "Leader Mucus Relief Sever Cold", "Cold Multi-Symptom", "Leader Nighttime Cold and Flu", "Day Time Cold and Flu Non drowsy", "Leader Mucus Relief Cold Flu and Sore Throat", "Leader Flu and Severe Cold and Cough", "Cold and Flu Severe Daytime and Nighttime", "Cold and Flu Severe Daytime and Nighttime", "Brompheniramine Maleate, Pseudoephedrine Hydrochloride and Dextromethorphan Hydrobromide", "Hanshinnocol", "Mucus Relief Daytime Severe Cold Nighttime Cold and Flu Maximum Strength", "Mucus Relief Daytime Severe Cold Nighttime Cold and Flu Maximum Strength", "Day Time Multi-Symptom Cold/Flu Relief", "Hanshinnocol", "Severe Cold Daytime", "Promethazine DM", "Cold Flu and Sore Throat Maximum Strength", "Daytime Nighttime Sinus Relief Maximum Strength", "Daytime Nighttime Sinus Relief Maximum Strength", "Basic Care childrens cold and cough and sore throat", "Childrens Dimetapp Multi-Symptom Cold Relief Dye-Free", "Daytime Cold Flu", "Leader tussin dm max adult", "Basic Care Daytime Cold and Flu", "Basic Care Childrens Cold Plus Flu", "Robitussin Maximum Strength Cough Plus Chest Congestion DM", "Robitussin Maximum Strength Severe Multi-Symptom 7 in 1 Relief Nighttime", "NightTime Cold and Flu Multi Symptom", "Basic Care Mucus DM", "Tussin DM Nighttime Cough Maximum Strength", "Wal Tussin CF Max Multi Symptom Cough Cold and Flu", "Basic Care Daytime Severe Cold Nighttime Cold and Flu", "Basic Care Daytime Severe Cold Nighttime Cold and Flu", "Topcare Day Time Nite Time Cold and Flu", "Topcare Day Time Nite Time Cold and Flu", "Circle K Nighttime Cold and Flu", "Basic Care Daytime Nighttime Severe Cold and Flu", "Basic Care Daytime Nighttime Severe Cold and Flu", "Basic Care Daytime Cold and Flu Severe", "Basic Care daytime nighttime severe cold and flu", "Basic Care daytime nighttime severe cold and flu", "Mucus Relief Severe Congestion and Cough Maximum Strength", "Mucus Relief DM", "Daytime and Nighttime Cough and Chest Congestion Childrens", "Daytime and Nighttime Cough and Chest Congestion Childrens", "Equate Adult Tussin DM Max Daytime Nighttime", "Equate Adult Tussin DM Max Daytime Nighttime", "Day Severe Cold Night Cold and Flu", "Day Severe Cold Night Cold and Flu", "Daytime Nighttime", "Daytime Nighttime", "Nitetime Cough", "Colcol-S", "Stop Cough PLUS", "Mucinar PLUS", "Mucinar PLUS", "Daytime Cold and Flu", "Febrix Kids PLUS", "Mucinar Kids PLUS", "Robitussin Peak Cold Multi-Symptom Cold", "Cold Head Congestion Daytime", "Cold and Flu Severe", "Childrens Robitussin Cough and Chest Congestion DM", "Childrens Cough and Sore Throat", "Childrens Robitussin Cough and Cold CF", "Daytime Nighttime Cold Flu Relief", "Daytime Nighttime Cold Flu Relief", "Childrens Dimetapp Long Acting Cough Plus Cold", "Aurotussin Peak Cold sugar-free COUGH PLUS CHEST CONGESTION DM", "TopCare Health Non Drowsy Daytime Cold and Flu Relief And Nighttime Cold and Flu Relief Day and Night Combo Pack", "TopCare Health Non Drowsy Daytime Cold and Flu Relief And Nighttime Cold and Flu Relief Day and Night Combo Pack", "Nighttime Cold and Flu Lil Drug Store Products", "Promethazine DM", "Topcare Nite Time Day Time Cold and Flu", "Topcare Nite Time Day Time Cold and Flu", "Whituben", "Tussin Multi Symptom Cold CF Adult", "Rabofen DM", "NiteTime Cough DayTime Cough", "NiteTime Cough DayTime Cough", "Night Time Cold and Flu", "Day Severe Cold and Night Cold and Flu Maximum Strength", "Day Severe Cold and Night Cold and Flu Maximum Strength", "Siltussin DM", "VanaTab DM", "Basic Care Daytime Cold and Flu", "Diabetic Siltussin DM DAS-Na", "Giltuss Allergy Plus Cough and Congestion", "Giltuss Cough and Cold", "Doc in the Box All Day Supply", "Giltuss MultiSymptom Cold and Flu", "Pharbinex-DM", "Giltuss Diabetic Cough and Cold", "Good Sense Day Time Night Time Cold and Flu", "Good Sense Day Time Night Time Cold and Flu", "Giltuss Childrens Cough and Chest Congestion", "Meds on the Go", "Giltuss Childrens Allergy Plus Cough and Congestion", "Giltuss Childrens MultiSymptom Cold and Flu", "Cold and Flu Daytime", "Giltuss HBP Cough and Chest Congestion", "Giltuss Childrens Cough and Cold", "Cold and Flu Daytime Relief", "Promethazine DM", "Siltussin DM", "NiteTime Cold Flu Relief", "Triacting Daytime Cold Cough Childrens", "Giltuss Cough and Cold", "DayTime Cold and Cough Childrens", "Sound Body Mucus DM", "Theraflu ExpressMax Daytime Severe Cold and Cough", "Nighttime Cold and Flu", "SanaTos X", "Mucus Relief Cold Flu Sore Throat Maximum Strength", "Mucus Relief Severe Cough and Congestion", "Mucus Relief Severe Congestion Cough Maximum Strength", "DayTime Cold and Flu", "Night Time Cherry Pseudo-Free", "Day Time with PE", "Severe Wal Tussin CF Max", "Cough Control DM Sugar Free", "Premier Value Maximum Strength", "VIcks Flu Therapy Severe Cold and Flu Day", "Rite Aid Mixed Berry Sore Throat and Cough Lozenge", "VIcks Flu Therapy Severe Cold and Flu Day", "Good Sense Tussin DM Cough and Chest Congestion", "Good Sense Tussin CF", "Good Sense Tussin DM", "Severe Cold and Flu", "Vicks childrens Cough Congestion", "Night Time Cold and Flu Relief Multi Symptom", "Cough and Cold HBP", "Vicks Childrens Cold Multi Symptom", "Vicks Cough and Cold Severe", "Vicks Cough and Congestion DM", "Daytime/Nighttime Cold and Flu Multi-Symptom Relief", "Daytime/Nighttime Cold and Flu Multi-Symptom Relief", "Poly-Hist DM", "Alahist DM", "Cold Multi-Symptom Severe", "Mucus Relief All in One Maximum Strength", "Cough and Cold HBP", "Daytime Nighttime cold and flu relief", "Daytime Nighttime cold and flu relief", "Cold Head Congestion Daytime Non-Drowsy", "Daytime Cold and Flu Nitetime Cold and Flu", "Daytime Cold and Flu Nitetime Cold and Flu", "Tussin Cough DM Sugar Free", "Daytime Cold and Flu", "NyQuil Severe plus Vicks VapoCool Cold and Flu", "Tussin DM cough and chest congestion", "Maximum Strength Mucus Relief DM", "Cold and Cough Childrens", "Daytime Cold and Flu Non Drowsy", "Cold, Flu and Sore Throat Maximum Strength", "Severe Congestion and Cold Maximum Strength", "Dye Free Cold and Flu", "Dye Free Cold and Flu", "NyQuil Severe Plus VapoCOOL Cold and Flu", "Basic Care Mucus Relief Cold Flu and Sore Throat", "DayQuil Severe Plus VapoCOOL Cold And Flu", "Cold, Flu, and Sore Throat", "Cold Flu and Sore Throat", "Severe Cold Plus Flu Daytime Nighttime", "Severe Cold Plus Flu Daytime Nighttime", "Cold Flu and Sore Throat", "Basic Care Nighttime", "Daytime Cold Cough Childrens", "Multi Symptom Severe Cold and Nighttime Severe Cold and Cough", "Daytime Nighttime Cold and Cough Childrens", "Basic Care Nighttime Cold and Flu", "Mucus Relief DM Extended Release Caplets Maximum Strength", "Nighttime Cold and Flu Relief", "Triacting Daytime Cold Cough Childrens", "Mucinex Childrens Cold and Flu", "Mucinex DM Maximum Strength", "Basic Care Daytime Nighttime Cold and Flu", "Basic Care Daytime Nighttime Cold and Flu", "Mucinex Childrens Cough Mini-Melts Orange Creme", "Basic Care Day Time Night Time Cold and Flu", "Basic Care Day Time Night Time Cold and Flu", "Mucus Relief Severe Congestion and Cough", "Daytime", "Topcare Tussin DM Max", "Cold and Flu Severe Daytime Nighttime", "Cold and Flu Severe Daytime Nighttime", "Triacting Daytime Cold Cough Childrens", "CVS Severe Tussin CF Max", "Mucinex Childrens Cough and Congestion", "Mucinex Junior Cold and Flu", "Multi Symptom Cold and Multi Symptom Nighttime Cold Childrens", "Premier Value", "Only For COLD AND FLU COUGH SUPPRESSANT", "Siltussin DM DAS Cough Formula", "Only For COUGH", "Basic Care Daytime Severe Cold Nighttime Cold and Flu", "Ultra Tuss Safe", "Ultra Tuss DM", "Childrens Robitussin Honey Cough and Chest Congestion DM", "Actinel DM", "Rugby Cough", "Mucinex Childrens Day Time Multi-Symptom Cold and Night Time Multi-Symptom Cold", "Night time Multi Sympton Cold Max", "Mucus Relief DM", "Night time cold and flu multi symptom", "Robafen DM", "Severe Cold and Cough Daytime", "Alka-Seltzer Plus Severe Sinus Congestion Allergy and Cough", "Alka-Seltzer Plus Cold and Cough Cool Menthol", "CVS Daytime Severe Cold and Flu Relief Softgels", "Robitussin Honey Maximum Strength Nighttime Cough DM", "Daytime Cold and Flu Non Drowsy", "Daytime Nighttime Cold and Flu Relief Multi-Symptom", "Daytime Nighttime Cold and Flu Relief Multi-Symptom", "CVS Health Maximum Strength Non Drowsy Day and Night Cold and Flu Max Softgels Minis", "CVS Health Maximum Strength Non Drowsy Day and Night Cold and Flu Max Softgels Minis", "Night Time Cold and Flu Relief Multi Symptom", "CVS Health Non Drowsy DAY Cold and Flu Plus and NIGHTTIME Cold and Flu Plus", "CVS Health Non Drowsy DAY Cold and Flu Plus and NIGHTTIME Cold and Flu Plus", "Tusnel DM", "Tusnel SF", "King-Tuss SF", "Tussin DM", "Tusnel Pediatric DM", "Limpia Pecho", "Geri-Tussin DM", "Mucus Relief DM Maximum Strength", "Dg Health Night Time Cold and Flu Relief", "Daytime Nighttime Cold and Flu Relief Multi-Symptom", "Daytime Nighttime Cold and Flu Relief Multi-Symptom", "Mucus Relief Severe Congestion and Cough Maximum Strength", "Night Time Cold and Flu Relief Multi Symptom", "Robafen", "Sun Mark Tussin DM cough and chest congestion", "Daytime Cold and Flu Non Drowsy", "Palagrip", "Mucus Relief DM", "Mucinex Nightshift Cold and Flu", "Mucinex Nightshift Cold and Flu Clear and Cool", "Mucinex Nightshift Sinus", "Mucinex Nightshift Sinus Clear and Cool", "Cold Multi-Symptom, Daytime", "7 Select Maximum Strength", "Tylenol Cold plus Flu plus Cough Night", "Guaifenesin and Dextromethorphan Hydrobromide", "Guaifenesin and Dextromethorphan Hydrobromide", "Mucus Relief DM", "DayTime NightTime Cold and Flu", "DayTime NightTime Cold and Flu", "Daytime Cold Flu Relief", "Daytime Nighttime Multi Symptom Cold Childrens", "DayTime Cold Flu Non-Drowsy", "Nitetime Cold Flu Relief", "Daytime cold and flu relief", "DAYTIME cold and flu relief", "Cold and Flu Relief Multi symptom", "DayTime NightTime Cold/Flu", "DayTime NightTime Cold/Flu", "Nighttime Cold and Flu Relief Multi-Symptom", "DayTime NiteTime Cold Flu Relief", "DayTime NiteTime Cold Flu Relief", "Major Night Time Multi Symptom cold and flu relief", "Daytime Nighttime Cold and Flu Relief Multi-Symptom", "Daytime Nighttime Cold and Flu Relief Multi-Symptom", "COLD and FLU DAYTIME MAXIMUM STRENGTH NON-DROWSY SEVERE", "NiteTime Cold plus Flu Releif", "Vicks NyQuil Cold and Flu Nighttime Relief", "DayQuil Severe plus Vicks VapoCool Cold and Flu", "Cough and Cold", "Cold and Flu Relief Multi symptom", "Cold and Flu Relief Multi symptom", "Cold and Flu Relief Multi Symptom Nighttime", "Daytime Flu Relief Therapy", "COLD, Flu and Sore Throat", "Childrens Dibromm Cold and Cough", "Nighttime Cough DM Max", "Equaline Mucus Relief", "Daytime Nighttime Cold Flu Relief", "Daytime Nighttime Cold Flu Relief", "Cold Relief Multi Symptom Nighttime", "Childrens Delsym Cough Plus Sore Throat", "Delsym Cough Plus Sore Throat", "Basic Care Nighttime Cold and Flu Severe", "LIDL Daytime Cold and Flu Relief Multi Symptom", "LIDL Nightyime Cold and Flu Relief", "Robitussin Maximum Strength 12 Hour Cough and Mucus Relief", "Basic Care Daytime Nighttime Cold and Flu", "Basic Care Daytime Nighttime Cold and Flu", "Severe Cold and Flu", "Mucus Relief Cold Flu Sore Throat Maximum Strength", "Triacting Day Time with PE", "Triacting Daytime Cold Cough Childrens", "NyQuil Severe plus Vicks VapoCool", "Vicks DayQuil Cold and Flu Multi-Symptom Relief", "Vicks NyQuil Severe Cold and Flu", "Mucus Relief DM", "Vicks NyQuil Severe Cold and Flu", "DayQuil Severe", "Childrens Cold and Cough", "Tussin Multi Symptom Cold CF", "Daytime Cold and Flu Multi-symptom Relief", "Vicks NyQuil Severe Cold and Flu", "Cold and Flu Multi-symptom Relief/cold and Flu Nighttime Relief", "Cold and Flu Multi-symptom Relief/cold and Flu Nighttime Relief", "Nighttime Cold and Flu Relief", "Cold and Flu Nighttime Relief", "Vicks DayQuil Severe Cold and Flu", "DayQuil Severe plus Vicks VapoCool", "Good Sense Mucus DM", "Cold and Flu", "Topcare Mucus DM", "Up and Up Mucus Relief DM", "NyQuil Severe Cold and Flu", "Pharbinex-DM", "flu HBP", "Tussin DM Adult", "Congestion and Cough Childrens", "Tussin DM Max Adult Cough and Chest Congestion", "Nighttime Cough", "Mucus Relief DM", "Leader Maximum Strength Mucus Relief DM", "Walgreens Grape Flavor", "Cough and Cold HBP", "Basic Care Mucus DM", "Cold and Flu Relief Nighttime", "Severe Congestion and Cough/ Cold and Flu Daytime/nighttime", "Cold and Flu DayTime", "CVS Health Multi Symptom Severe Cold MULTI SYMPTOM SEVERE COLD", "Daytime Nighttime Cold Flu Relief", "Daytime Nighttime Cold Flu Relief", "Multi-Symptom Cold Flu and Sore Throat Maximum Strength", "Daytime Cold and Flu Nighttime Cold and Flu", "Daytime Cold and Flu Nighttime Cold and Flu", "Mucus Relief DM", "Tylenol Cold Plus Flu Severe", "Daytime Cold and Flu Non Drowsy", "Equaline Daytime Cold and Flu Fast Relief Nighttime Cold and Flu Fast Relief", "Equaline Daytime Cold and Flu Fast Relief Nighttime Cold and Flu Fast Relief", "Tussin DM Adult", "Cold and Flu Nighttime Relief", "Cold and Flu severe", "Cold and Flu Daytime Relief", "Mucus Relief Severe Congestion and Sinus", "Careone Day Cold and Flu Night Cold and Flu", "Careone Day Cold and Flu Night Cold and Flu", "Mucus Relief DM Extended Release Caplets", "Mucus Relief Maximum StrengthCold Flu and Sore Throat", "Basic Care Day Time Cold and Flu Night Time Cold and Flu", "Basic Care Day Time Cold and Flu Night Time Cold and Flu", "Multi Symptom Severe Cold", "Mucus Relief Severe Congestion and Cough Maximum Strength", "Vicks DayQuil and Vicks NyQuil Cold and Flu Multi-Symptom Relief/Cold and Flu Nighttime Relief", "Vicks DayQuil and Vicks NyQuil Cold and Flu Multi-Symptom Relief/Cold and Flu Nighttime Relief", "Walgreens Childrens", "Walgreens Daytime Childrens", "Topcare Day Time Cold and Flu", "Childrens Pain Relief Cold and Cough and Sore Throat", "Topcare Nite Time Cold and Flu", "Daytime Nighttime Severe Cold and Flu", "Daytime Nighttime Severe Cold and Flu", "Multi Symptom Severe Cold and Nighttime Severe Cold and Cough", "Severe Cold and Flu", "Severe Cold and Flu", "Welby Day Time Cold and Flu", "Childrens Cold and Cough", "Cough Control DM Max", "DM Max Relief Maximum Strength", "Adult Tussin Cough and Chest Congestion DM Sugar Free", "Childrens Plus Multi Symptom Cold", "Tussin CF Maximum Strength", "Vicks DayQuil Severe and Vicks NyQuil Severe Cold and Flu", "Vicks DayQuil Severe and Vicks NyQuil Severe Cold and Flu", "Mucus Relief Severe Congestion and Cold Max Maximum Strength", "Severe Congestion and Cough, Cold and Flu Daytime and Nighttime", "Up and Up Nighttime Vapor Ice Cold and Flu", "Vicks NyQuil HBP Cold and Flu", "Nighttime Severe Cold and Flu", "Cold and Flu Nighttime/Multi-Symptom", "Cold Multi-Symptom Non-Drowsy, Daytime", "Cold and Flu Nighttime Multi-symptom", "Multi-Symptom Cold Relief", "Multi-Symptom Cold Relief", "Severe Congestion and Cough, Cold and Flu Daytime, Nighttime", "Tukol X-Pecto Miel Multi Symptom Cold", "DayTime Cold and Flu", "Cold and Flu Non-Drowsy, DayTime", "Mucus Relief Daytime/Nighttime", "Topcare Mucus Relief", "Tukol Multi Symptom Cold", "Nighttime Cold and Flu", "Severe Cold and Flu Daytime", "Severe Cough and Cold", "Cold and Flu Relief Daytime", "Night Time Cold and Flu Relief Multi Symptom", "Daytime Cold and Flu Non Drowsy", "Daytime Nighttime Cold Flu Relief", "Daytime Nighttime Cold Flu Relief", "Leader Flu and Severe Cold and Cough", "Health Mart Severe Cold Cough and Flu", "Good Neighbor Pharmacy Flu and Severe Cold and Cough", "Careone Daytime Severe Cold and Cough", "Topcare Flu and Severe Cold and Cough Daytime", "Healthy Accents Severe Cold Daytime", "Flu and Severe Cold", "Good Sense Flu and Severe Cold and Cough Daytime", "TopCare Multi Symptom Severe Cold", "Equaline Multi Symptom Flu and Severe Cold Daytime", "Signature Care Daytime Severe Cold", "Good Sense Multi Symptom Flu and Severe Cold", "Daytime Nighttime Severe Cold Cough and Flu Relief", "Daytime Nighttime Severe Cold", "Severe Cold and Flu", "Dg Health Multi Symptom Severe Cold", "Wal Flu Severe Cold and Cough Daytime Nighttime", "Basic Care Daytime Severe Cold and Flu Nighttime Severe Cold, Cough and Flu", "Daytime Severe Cold and Flu Nighttime Severe Cold, Cough and Flu", "Daytime Nighttime Severe Cold and Flu", "Severe Cold", "Leader multi symptom flu and severe cold", "Flu and Severe Cold", "Sound Body Severe Cold and Flu", "Flu and severe cold daytime nighttime", "Basic Care Severe Cold and Flu", "Severe Cold and Flu Relief Daytime/Nighttime", "Severe Cold and Flu Relief Daytime/Nighttime", "Vicks NyQuil Cold and Flu Nighttime Relief", "NiteTime Cold and Flu", "Daytime Cold and Flu Non drowsy", "Vicks Childrens NyQuil Cold and Cough Multi-Symptom Relief", "Vicks NyQuil Cold and Flu Nighttime Relief", "CareOne Severe Cold", "Mucus Relief Maximum Strength", "Sunmark Cold and Cough DM Childrens", "Health Mart Childrens Mucus Relief Cough", "Vicks Childrens NyQuil Cold and Cough Multi-Symptom Relief", "Good Neighbor Pharmacy Severe Cold", "HealthMart Chest Congestion Relief DMDM DM", "Sunmark Chest Congestion Relief DM DM", "Health Mart Daytime", "Health Mart Adult Tussin DM", "Equate Severe Cold Multi Symptom", "Up and Up Daytime Vapor Ice Cold and Flu Nighttime Vapor Ice Cold and Flu", "Up and Up Daytime Vapor Ice Cold and Flu Nighttime Vapor Ice Cold and Flu", "Cold and Flu Non-Drowsy, Daytime", "Up and Up Daytime Vapor Ice Cold and Flu Nighttime Vapor Ice Cold and Flu", "Up and Up Daytime Vapor Ice Cold and Flu Nighttime Vapor Ice Cold and Flu", "Multi Symptom Cold Childrens Plus", "Topcare Day Night", "Topcare Day Night", "Vicks DayQuil and Vicks NyQuil Cherry Cold and Flu", "Vicks DayQuil and Vicks NyQuil Cherry Cold and Flu", "Vicks DayQuil and Vicks NyQuil Cold and Flu", "Vicks DayQuil and Vicks NyQuil Cold and Flu", "Health Mart mucus relief DM", "Sunmark mucus relief DM", "Vicks DayQuil Severe Cold and Flu", "Severe cold and flu Nighttime", "Vicks NyQuil Severe Cold and Flu", "Vicks DayQuil and Vicks NyQuil Severe Cold and Flu", "Vicks DayQuil and Vicks NyQuil Severe Cold and Flu", "Vicks Alcohol Free NyQuil Cold and Flu Nighttime Relief", "Vicks NyQuil Cough", "Vicks DayQuil Tropical and Vicks NyQuil Cherry Cough", "Vicks DayQuil Tropical and Vicks NyQuil Cherry Cough", "7 Select Night Time Relief", "Cold Multi-Symptom Nighttime", "cold and sinus PE", "Severe Cold", "cough and sinus PE", "Mucus Relief All In One Cold and Flu", "Mucus Relief Sinus Pressure, Pain and Cough", "Cold and Flu Severe", "Cold Relief Multi-symptom Daytime", "Mucus Relief Cold Flu and Sore Throat", "Cold and Flu Daytime/Multi-Symptom/Non-Drowsy", "Cold and Flu Relief Non-Drowsy, DayTime, Multi-Symptom", "Mucus Relief Daytime/Nighttime/Maximum Strength", "DayTime Cold and Flu Non Drowsy", "Mucus Relief DM", "7 select Tussin DM", "7 Select Night Time Relief", "Promethazine DM", "Maximum Strength Mucus Relief DM", "Childrens Mucus and Cough Relief", "Cold and Flu Severe, Nighttime, Maximum Strength", "Mucus Relief Maximum Strength Multi Symptom Relief", "Up and Up maximum Strength fast mucus relief Severe Congestion and Cough", "Childrens Mucus and Cough Relief", "Severe Cold and Cough Daytime", "Stona Cough", "Dg Health Day Time Severe Cold and Flu Relief", "7 Select Day Time Relief", "Acetaminophen 500mg, Dextromethorphan HBr 10mg, Guaifenesin 200mg, Phenylephrine HCl 5mg", "Childrens Plus Cough and Runny Nose", "7 Select Day Time Relief", "Father Johns Cough Medicine Plus", "Vicks DayQuil and Vicks NyQuil Severe Cold and Flu", "Vicks DayQuil and Vicks NyQuil Severe Cold and Flu", "NyQuil Severe VapoCool", "DayQuil Severe VapoCool", "Childrens Pain Relief Cold and Flu", "Cough and Cold HBP", "Presgen", "Cold and Flu Relief NightTime, Multi-symptom", "Mucus Relief DM Maximum Strength", "Pressure plus Pain PE plus Cough", "Tussin DM Cough and Chest Congestion", "Topcare Day Time Cold and Flu", "Tusslin Pediatric", "Topcare Nite Time Cold and Flu", "Non-drowsy Day Time", "G-tron Ped", "Topcare Childrens Cold and Flu", "Desgen Pediatric", "Health Mart Multi-Symptom Cold and Flu Night Time", "Maximum Strength Mucus Relief Cold,Flu and Sore Throat", "Guaifenesin and Dextromethorphan Oral Solution", "Guaifenesin and Dextromethorphan Oral Solution", "Mucus Relief Cold Flu Sore Throat Maximum Strength", "Mucus DM Extended Release", "Maximum Strength Mucus Relief Severe Congestion and Cough", "Pecgen Dmx", "Daytime Cold and Flu Relief", "Maximum Strength Mucus Relief Severe Congestion and Cough", "Chloresin", "Tukol Cough And Cold Honey Flavor", "Multi-symptom Nitetime", "Multi-Symptom Cold Daytime", "Equate Tussin DM adult", "Night Time Cold and Flu Relief Multi Symptom", "Tusslin", "Childrens Cold and Flu", "Daytime Nighttime Cold Flu Relief", "Daytime Nighttime Cold Flu Relief", "Nighttime Cold and Flu", "Equate Tussin CF", "Extra action Cough", "Pedia Relief", "Kidkare cough/cold", "Maximum Strength Mucinex Fast-Max Cold and Flu", "Rabofen DM", "Flu HBP Maxium Strength", "Robafen DM Cough Sugar Free Clear", "Day Time Severe Cold and Cough", "DayTime Nighttime multi symptom cold and flu relief", "DayTime Nighttime multi symptom cold and flu relief", "Multi Symptom Cold CF Adult", "Equate Daytime Cold and Flu", "Day Time with PE", "Childrens Plus Multi-Symptom Cold Grape with PE", "Tussin CF", "Severe Cold and Cough Daytime", "Tussin Cough and Chest Congestion DM", "Wal-Phed PE Multi Symptom", "Flu Relief Therapy Day Time", "Mixed Berry Sore Throat and Cough lozenge", "Night Time Pseudo-Free", "Tussin Cough and Chest Congestion DM Sugar Free", "Cold and Flu Relief Daytime, Multi-Symptom", "Night Time Original Pseudo-Free", "Multi Symptom Severe Cold and Nighttime Severe Cold and Cough", "Multi Symptom Wal Flu Severe Cold", "Night Time Cherry Pseudo-Free", "Cold Relief Multi-Symptom Severe", "Severe cold and cough relief", "Cold Relief Cold and Flu Severe", "childrens Multi Symptom Fever and Cold", "Cough Syrup DM", "childrens Wal Tussin Cough and Cold", "Mucus Relief Cold Flu and Sore Throat", "Cold Relief Head Congestion Severe", "Cold and Flu Relief Nighttime", "Cold Relief Multi-Symptom Daytime", "Mucus Relief DM", "Broncolin Cold and Flu Relief", "Severe Congestion and Cold Maximum Strength/ Multi-Symptom", "Daytime Nighttime Cold and Flu Relief Multi-Symptom", "Daytime Nighttime Cold and Flu Relief Multi-Symptom", "Severe Cold and Mucus", "Cold and Flu Relief Multi Symptom Nighttime", "Daytime Nighttime Cold and Flu Relief Multi-Symptom", "Daytime Nighttime Cold and Flu Relief Multi-Symptom", "Cold and Flu Relief Multi symptom", "Cold and Flu Relief Multi symptom", "Equate Nighttime Cold and Flu", "Cold and Flu Nighttime", "Cold and Flu Relief DayTime", "Cold MULTI-SYMPTOM, DAYTIME / NIGHTTIME", "Cold MULTI-SYMPTOM, DAYTIME / NIGHTTIME", "NightTime Cough DM Maximum Strength", "Nighttime Cold Max", "Tussin Cough and Chest Congestion DM", "Tussin DM Cough and Chest Non Drowsy", "Cold and Flu Relief Multi symptom", "Cold and Flu Relief Nighttime", "Cold and Flu Nighttime", "Cold and Flu DayTime", "Tussin CF Non Drowsy Multi Symptom", "Childrens Cold and Cough", "Daytime Nighttime Cold Flu Relief", "Daytime Nighttime Cold Flu Relief", "Daytime Nighttime Cold and Flu Relief Multi-Symptom", "Daytime Nighttime Cold and Flu Relief Multi-Symptom", "NiteTime Cold and Flu", "Tussin Multi Symptom Cold CF Adult", "Cold Max", "Night Time Cold and Flu Relief Multi Symptom", "Mucus Relief Severe Congestion and Cough Maximum Strength", "Tussin DM Cough and Chest Congestion", "Tussin CF Non Drowsy Multi Symptom", "Tussin Cough and Chest Congestion DM Sugar Free", "Cough Relief Nighttime", "Theraflu Expressmax Daytime Severe Cold and Cough and Theraflu Expressmax Nighttime Severe Cold and Cough", "Childrens Plus Multi Symptom Cold", "Nite Time Cold and Flu", "Daytime Cold and Flu", "DayTime Multi-Symptom", "Cold and Flu Relief Multi Symptom Nighttime", "Mucus Relief Cold, Flu, Sore Throat Maximum Strength", "Cold and Flu Nighttime", "Cold and Flu Relief Multi symptom", "Tussin Cough and Chest Congestion DM Sugar Free", "Cough and Cold HBP Maximum Strength", "Daytime Cold and Flu", "Cold and Flu Nighttime", "Tussin Cough and Chest Congestion DM Adult", "Cough Relief Nighttime", "Mucus Relief DM MAX Maximum Strength", "Cold Multi-Symptom", "Cough and Congestion DM Sugar Free", "Childrens Plus Cough and Runny Nose", "Childrens Day Time Cold and Cough", "Severe Cold, Cold and Flu Maximum Strength, Daytime, Nightime", "Guaifenesin and Dextromethorphan Hydrobromide", "Severe Cold", "Cold and Flu Relief Nighttime, Multi-Symptom", "Cough and Chest Congestion DM Maximum Strength", "Childrens Plus Cough and Runny Nose", "Childrens Plus Multi Symptom Cold", "Daytime Cold and Flu Relief", "Cough Cold and Sore Throat Childrens", "Mucus Relief Cold Flu and Sore Throat Maximum Strength", "Robitussin Maximum Strength Cough Plus Chest Congestion DM", "Cough and Chest Congestion DM Maximum Strength", "Cold and Flu Daytime, Nighttime", "Multi-Symptom Cold Daytime", "Mucus Congestion and Cough Relief Childrens", "Daytime Nighttime Cold and Cough Childrens", "Robitussin Honey Maximum Strength Cough and Chest Congestion DM", "Cold Flu Severe Day Night", "Cold Flu Severe Day Night", "Severe Cold Multi Symptom", "Family Wellness Multi Symptom Severe Cold", "Cold Flu Severe", "Severe Cold and Flu Maximum Strength, Daytime, Non-Drowsy", "Daytime Severe Cold and Flu Maximum Strength", "Topcare Mucus Relief Cold and Flu", "Cold Multi Symptom Nighttime", "Cold Multi-Symptom Nighttime", "Mucus Relief Cold Flu and Sore Throat Maximum Strength", "Mucus Relief Severe Cold", "Mucus Relief Cold Flu and Sore Throat Maximum Strength", "Cold Head Congestion Nighttime", "Mucus Relief Severe Cold", "Pressure and Pain and Cold", "Mucus Relief Cold Flu and Sore Throat", "Mucus Relief Maximum StrengthCold Flu and Sore Throat", "Cold Multi Symptom Daytime Nighttime", "Cold Multi Symptom Daytime Nighttime", "Mucus Relief Cold Flu Sore Throat Maximum Strength", "Mucus Relief Cold, Flu and Sore Throat", "Cold Multi-Symptom Daytime and Nighttime", "Cold Multi-Symptom Daytime and Nighttime", "Wal-Phed PE, Multi-Symptom, Daytime, Nighttime", "Mucus Relief DM Extended Release Caplets", "Cold Flu and Sore Throat", "Cold and Flu", "Severe Congestion and Cough, Cold and Flu Daytime, Nighttime", "Cold Multi-Symptom Severe", "Pressure Pain Cold", "Cold Flu Severe", "Mucus Relief DM", "Mucinex Fast-Max Congestion and Headache", "Severe Cold and Flu", "Mucinex Sinus-Max Severe Congestion and Pain", "Cold Max", "Mucus Relief DM Extended Release Caplets", "Maximum Strength Mucinex Fast-Max Day Cold and Flu and Night Cold and Flu", "Maximum Strength Mucinex Fast-Max Day Cold and Flu and Night Cold and Flu", "Daytime Mucus Relief Severe Congestion and Cough and Nighttime Cold and Flu Maximum Strength", "Good Sense Tussin DM", "Cold Max", "Daytime Mucus Relief Severe Cold Nighttime Cold and Flu Maximum Strength", "Daytime Mucus Relief Severe Cold Nighttime Cold and Flu Maximum Strength", "Pressure Pain Cold", "Cold Flu Sore Throat", "Mucus Relief Severe Cold Daytime Maximum Strength", "Mucus Relief DM Max Maximum Strength", "Mucus Relief DM Extended Release Caplets Maximum Strength", "Mucinex Fast-Max Cold, Flu and Sore Throat", "Severe Cold", "Sinus Relief Maximum Strength", "Multi-Symptom Cold Relief Daytime", "Acetaminophen, Dextromethorphan Hydrobromide, Guaifenesin, Phenylephrine Hydrochloride", "Severe Cold and Flu Relief Daytime/Nighttime", "Severe Cold and Flu Relief Daytime/Nighttime", "Mucinex Sinus - Max Day / Night", "Mucinex Sinus - Max Day / Night", "Daytime Mucus Relief Severe Cold Nighttime Cold and Flu Maximum Strength", "Daytime Mucus Relief Severe Cold Nighttime Cold and Flu Maximum Strength", "Daytime Nighttime Sinus Relief Maximum Strength", "Daytime Nighttime Sinus Relief Maximum Strength", "Cold Flu Severe", "Cough and Runny Nose Childrens Plus", "Severe Cold and Cough Daytime", "Cold Multi-Symptom Daytime", "Equate Nighttime Vapor Ice Cold and Flu", "Mucus Relief DM Maximum Strength", "Flu Relief Childrens", "Equate Daytime Vapor Ice Cold and Flu", "Cold Flu Severe Day Night", "Cold Flu Severe Day Night", "DayTime Mucus Relief Severe Cold and Nighttime Cold and Flu Maximum Strength", "Daytime Liquid Caps", "Mucus Relief Cold Flu and Sore Throat Maximum Strength", "Topcare Day Time Nite Time Cold and Flu", "Topcare Day Time Nite Time Cold and Flu", "Cold Multi-Symptom Daytime Nighttime", "Cold Multi-Symptom Daytime Nighttime", "Cough and Cold HBP", "Mucus Relief DM Max Maximum Strength", "Mucus Relief Severe Congestion and Cough Maximum Strength", "Daytime Cold and Cough and NightTime Cold and Congestion Childrens", "Mucus Relief DM Extended Release", "Fast Mucus Relief Cold Flu and Sore Throat Maximum Strength Multi-Symptom", "Daytime Mucus Relief Severe Cold Nighttime Cold and Flu Maximum Strength", "Daytime Mucus Relief Severe Cold Nighttime Cold and Flu Maximum Strength", "Cold Max Daytime", "DayTime Mucus Relief Severe Cold and Nighttime Cold and Flu Maximum Strength", "Sanaflu Nighttime Xtreme Multi Symptom Cold Flu Relief Cherry Flavor", "Cold Plus Head Congestion Nighttime", "Mucus Relief DM MAX Maximum Strength", "Mucus Relief Congestion and Cough Maximum Strength", "Cold Plus Head Congestion Daytime", "Mucus Relief Severe Cold Daytime Maximum Strength", "Pressure Plus Pain PE Plus Cough", "Mucus Relief Cold, Flu and Sore Throat", "Pressure Plus Pain PE Plus Cold", "Sunmark Adult Tussin DM", "Cold Plus Head Congestion Day and Night", "Cold Plus Head Congestion Day and Night", "Cold Max Nighttime", "Mucus Relief Severe Cold Daytime Cold and Flu Nighttime", "Equate Daytime Cold and Flu", "Cold Max Severe", "Day Time Cold and Flu", "Delsym Cough Plus Chest Congestion DM", "Childrens Plus Multi Symptom Cold", "Cold Max Day and Night", "Cold Max Day and Night", "Night Time Cough", "Cold and Flu Nighttime", "Cold Flu Severe", "Childrens Plus Multi Symptom Cold", "Cold and Flu Nighttime", "Nighttime Cold and Flu Cherry", "Nighttime Cold and Flu", "Mucus Relief DM Extended Release Caplets", "Multi-Symptom Cold Severe, Non-Drowsy, Daytime", "Night Time Cold and Flu", "Cold Head Congestion", "Day Time Cold and Flu non drowsy", "Delsym Cough Plus Chest Congestion DM and Delsym Cough Plus Cold Night Time", "Multi Symptom Cold and Flu Relief Nighttime", "Tussin Cough and Chest Congestion DM Adult", "Tussin Multi Symptom Cold CF Adult", "Cold and Flu Nighttime", "Nighttime cold and flu", "Mucus DM", "Daytime Cold and Flu multi symptom", "Nighttime Multi Symptom Cold and Flu Relief", "Daytime Severe Cold and Flu", "Guaifenesin DM", "Flu HBP Maximum Strength", "Cold and Flu Relief Multi-Symptom, Day, Night", "Cold and Flu Relief Multi-Symptom, Day, Night", "Daytime Nighttime Cold and Flu", "Daytime Nighttime Cold and Flu", "Mucus Relief DM Cough Maximum Strength", "Childrens Mucus Relief DM", "Multi-Symptom Cold", "Multi Symptom Cold Relief CF Non Drowsy", "Severe Cold Daytime Multi-Symptom Non-Drowsy", "Childrens Cough and Chest Congestion DM", "Cold and Flu DayTime", "Childrens Mucus Relief Chest Congestion Plus Cough", "Daytime Mucus Relief Severe Cold and Nighttime Cold and Flu Maximum Strength", "Daytime Mucus Relief Severe Cold and Nighttime Cold and Flu Maximum Strength", "Robafen DM Peak Cold Sugar-free Cough Plus Chest Congestion DM", "Childrens Cough and Chest Congestion DM", "Severe Cold, Cold and Flu Daytime, Nighttime, Maximum Strength", "Nuedexta", "Daytime Non Drowsy", "Night Time Cough", "Night Time Cough", "Mucinex DM", "NightTime Cold and Flu Multi Symptom", "Cold and Flu Relief Nighttime", "Nighttime Cold and Flu Relief", "Daytime Cold and Flu Relief Non Drowsy", "Nighttime Cold and Flu Relief", "Daytime Nighttime Cold Flu Relief", "Daytime Nighttime Cold Flu Relief", "Sinus PE Pressure, Pain and Cold Daytime, Non-Drowsy", "Nighttime Cold and Flu Relief Multi Symptom", "Physicians Care Cold Cough", "Cold Flu and Sore Throat Maximum Strength", "Health Mart Severe Cold and Flu", "Robitussin Cough Plus Chest Congestion DM", "Flu and Severe Cold Daytime Relief", "Tussin CF Maximum Strength", "Night Time Cold and Flu Relief Multi Symptom", "Daytime Nighttime Sinus Relief Maximum Strength", "Daytime Nighttime Sinus Relief Maximum Strength", "Health Mart Childrens Cold and Flu", "Tussin DM Maximum Strength", "Mixed Berry Sore Throat and Cough Lozenges", "Severe Cold and Flu", "Daytime Cold and Flu Relief Non Drowsy", "Daytime Mucus Relief Severe Cold and Nighttime Cold and Flu Maximum Strength", "Daytime Mucus Relief Severe Cold and Nighttime Cold and Flu Maximum Strength", "Cold Relief Multi Symptom Severe", "Cold Relief Multi-Symptom, Daytime, Nighttime, Non-drowsy", "Cold Relief Multi-Symptom, Daytime, Nighttime, Non-drowsy", "DayTime NightTime Cold/Flu", "Nighttime Cold and Flu Relief", "Daytime Cold and Flu Relief Multi-Symptom", "DS Never Cold S", "Cold and Flu Relief Daytime", "Childrens Plus Cough and Runny Nose", "Daytime Nighttime Cold Flu Relief", "Daytime Nighttime Cold Flu Relief", "Multi-Symptom Cold and Flu DayTime", "Daytime Nighttime Cold Flu Relief", "Daytime Nighttime Cold Flu Relief", "Multi-Symptom Cold and Flu DayTime", "Mixed Berry Sore Throat and Cough Lozenge", "Cold, Flu and Sore Throat Relief Maximum Strength, Multi Symptom", "Childrens Plus Multi Symptom Cold", "Equate Nighttime Cold and Flu", "Walgreens Severe Warming Cold and Flu For Adults", "Mucus Relief Cold Flu and Sore Throat Maximum Strength", "Daytime Severe Cold and Flu Relief Softgels", "AuroMucus - Fast Maximum Cold, Flu and Sore Throat Relief", "KMart - Fast Maximum Cold, Flu and Sore Throat Relief", "Triacting Day Time Cold and Cough Childrens", "Tussin DM Cough and Chest Congestion", "Walgreens Severe Cold Multi-Symptom For Adults", "AuroMucus - Childrens Multi-Symptom Cold", "Severe Nighttime Cold and Flu", "Multi Symptom Nitetime", "Daytime Cold and Flu Non Drowsy", "Night Time Cold Max", "AuroMucus - Fast Maximum Severe Congestion and Cough", "AuroFlu Day Time Severe Cold and Cough Warming Relief", "Severe Cold and Flu Daytime Non Drowsy Nighttime", "Severe Cold and Flu Daytime Non Drowsy Nighttime", "Multi Symptom Cold and Multi Symptom Nighttime Cold Childrens", "Daytime Nighttime Cold Flu Relief", "Daytime Nighttime Cold Flu Relief", "AuroMucus - Fast Maximum DM MAX", "Tussin Peak Cold sugar-free COUGH PLUS CHEST CONGESTION DM", "KMart - Fast Maximum Severe Congestion and Cough", "Walgreens Daytime non-drowsy cold multi-symptom for adults", "Medique Guaicon DMS", "Mucus Relief Maximum Strength Severe Congestion and Cough", "KMart - Fast Maximum DM MAX", "Daytime Nighttime Cold Flu Relief", "Daytime Nighttime Cold Flu Relief", "Severe Cold and Mucus", "Childrens Daytime Cold and Cough", "Mucus Relief Plus", "Cold and Flu Nighttime Relief", "Daytime Cold and Flu Multi symptom relief", "Childrens Aurotussin Cough and Chest Congestion DM", "NightTime Relief Severe Cold and Flu", "Mucus Relief Severe Congestion and Cough Maximum Strength", "Aurotussin Peak Cold Maximum Strength Multi-Symptom Cold", "Mucus Relief Cold Flu Sore Throat", "Mucinex DM", "Multi Symptom Cold CF", "Aurophen Cold Multi Symptom", "Daytime Mucus Relief Severe Congestion and Cough and Nighttime Cold and Flu Maximum Strength", "Aurophen Cold Multi-Symptom Severe", "Mucus Relief DM", "Walgreens NightTime Cold and Flu", "Daytime Relief Severe Cold and Flu", "Walgreens Daytime Non-Drowsy Cold and Flu", "Walgreens Daytime Non-Drowsy Cold and Flu", "Walgreens NightTime Cold and Flu", "Aurophen Cold Multi Symptom", "Aurotussin Peak Cold Cough plus Chest Congestion DM", "Childrens Aurotussin Cough and Cold CF", "Aurophen Cold and Flu Severe", "Multi Symptom Cold Double Max Power", "SanaTos Mucus Relief Cold Toddlers", "COLD and FLU Nighttime Relief", "COLD and FLU Nighttime Relief", "Severe Cold Daytime", "Childrens Daytime Cold and Cough", "AuroMucus - Childrens Cough", "Mucus DM", "Vanacof DM", "Tussin DM Max Adult Cough Plus Chest Congestion", "Mucus Relief All In One Daytime Nighttime Cold Flu Maximum Strength", "Safetussin PM", "Presgen B", "Tussin Cough and Chest Congestion DM Adult", "Safetussin DM", "AuroQuil Cough Nighttime Cough Relief", "Aurotussin Peak Cold Multi-Symptom Cold", "Coricidin HBP Nighttime Multi-Symptom Cold", "Alka-Seltzer Plus Maximum Strength Severe Sinus, Allergy and Cough", "Alka-Seltzer Plus Maximum Strength Severe Sinus Congestion and Cough Day and Night", "Alka-Seltzer Plus Maximum Strength Severe Sinus Congestion and Cough Day and Night", "Alka-Seltzer Plus Maximum Strength Day Cold and Flu", "Alka-Seltzer Plus Maximum Strength Day and Night Cold and Flu", "Alka-Seltzer Plus Maximum Strength Day and Night Cold and Flu", "Alka-Seltzer Plus Maximum Strength Night Cold and Flu", "Alka-Seltzer Plus Maximum Strength Night Cold and Flu PowerMax Gels", "Handy Solutions Cold Relief", "DayTime Cold Flu Non Drowsy", "Alka-Seltzer Plus Maximum Strength Day and Night Cold and Flu PowerMax Gels", "Alka-Seltzer Plus Maximum Strength Day and Night Cold and Flu PowerMax Gels", "DayTime Cold Flu Non Drowsy", "Alka-Seltzer Plus Maximum Strength Day and Night Cold and Flu", "Alka-Seltzer Plus Maximum Strength Day and Night Cold and Flu", "Alka-Seltzer Plus Maximum Strength Cold and Cough", "Alka-Seltzer Plus Maximum Strength Day and Night Cold and Flu PowerMax Gels", "Alka-Seltzer Plus Maximum Strength Day and Night Cold and Flu PowerMax Gels", "Alka-Seltzer Plus Multi-Symptom Cold and Flu Day and Night Liquid Gels", "Alka-Seltzer Plus Multi-Symptom Cold and Flu Day and Night Liquid Gels", "Alka-Seltzer Plus Severe Cough Mucus and Congestion Day and Night", "Alka-Seltzer Plus Severe Cough Mucus and Congestion Day and Night", "Alka-Seltzer Plus Maximum Strength Day Cold and Flu PowerMax Gels", "Alka-Seltzer Plus Severe Cough Mucus and Congestion Liquid Gels", "Severe Cold and Flu nighttime", "Coricidin HBP Cough and Cold Cough Suppressant, Antihistamine", "Alka-Seltzer Plus Severe Sinus Cold and Cough Liquid Gels", "Tussi Pres B", "Severe Cold and Cough Relief Daytime", "Childrens Mucus Relief", "Nighttime Cold and Flu Relief Multi Symptom", "Cough Mucus Relief DM", "Mucus Relief Cold, Flu, and Sore Throat Maximum Strength", "Promethazine Hydrochloride and Dextromethorphan Hydrobromide", "Cold and Flu Severe, Day and Nighttime", "Cold and Flu Severe, Day and Nighttime", "Mucus Relief Congestion and Cough Maximum Strength", "Rescon DM", "Mucus Relief Daytime Severe Cold Nighttime Cold and Flu Maximum Strength", "Mucus Relief Daytime Severe Cold Nighttime Cold and Flu Maximum Strength", "Maximum Strength Mucinex Fast-Max Cold and Flu", "Brompheniramine Maleate, Pseudoephedrine Hydrochloride, Dextromethorphan Hydrobromide", "Tussin Multi Symptom Cold CF", "Daytime Nighttime Cold and Flu Relief Multi-Symptom", "Daytime Nighttime Cold and Flu Relief Multi-Symptom", "Night Cold Flu Cough and Allergy", "Safetussin PM", "Night Time Cold and Flu Relief", "Childrens Mucus Relief cough", "Cold and Flu Relief Nighttime", "Cold Flu Relief Daytime", "Cold and Flu Nighttime", "Cold and Cough Nighttime Cool Blast", "Guaiasorb DM", "Cough Relief Nighttime", "Tussin CF Non Drowsy", "Safetussin DM", "Nighttime Cold and Flu Relief Multi-Symptom", "Cold and Flu Nighttime", "Cough Relief Nighttime", "Cough Relief Nighttime", "Cough and Cold plus", "Maximum Strength-Cough and Chest Congestion DM", "Tussin DM Sugar Free", "Tussin Cough DM Sugar Free", "Daytime Non Drowsy", "Cold and Cough Childrens", "Mucus Relief Cold Flu and Sore Throat Maximum Strength", "Mucus Relief DM Max Maximum Strength", "Mucus Relief DM Maximum Strength", "Welby Nighttime Cold and Flu", "Nighttime Cold and Flu", "Daytime Cold and Flu Non Drowsy", "Tussin DM Cough and Chest Congestion Non Drowsy", "Mucus Relief DM Max Maximum Strength", "DayTime Cold and Flu", "Nighttime Cold and Flu Relief Multi-Symptom", "Mucus Relief Cold Flu and Sore Throat Maximum Strength", "Mucus Relief Severe Congestion and Cough Maximum Strength", "Mucus Relief Severe Congestion and Cough Maximum Strength", "Cold and Flu Relief Daytime", "Tussin DM Sugar Free Non Drowsy", "Brompheniramine Maleate, Pseudoephedrine Hydrochloride, and Dextromethorphan Hydrobromide", "Good Sense Tussin DM", "Daytime Nighttime Cold Flu Relief Multi Symptom", "Daytime Nighttime Cold Flu Relief Multi Symptom", "Topcare Day Time Nite Time Cold and Flu", "Topcare Day Time Nite Time Cold and Flu", "Basic Care Daytime Nighttime Severe Cold and Flu", "Basic Care Daytime Nighttime Severe Cold and Flu", "Tussin DM", "Day Time Cold and Flu Severe", "Daytime Nighttime Sinus Relief Maximum Strength", "Daytime Nighttime Sinus Relief Maximum Strength", "DayTime Cold and Flu Severe and NightTime Cold and Flu Severe", "DayTime Cold and Flu Severe and NightTime Cold and Flu Severe", "Leader Tussin", "Night Time Cold and Flu Severe", "Day and Night Severe Sinus Congestion and Cough Maximum Strength", "Day and Night Severe Sinus Congestion and Cough Maximum Strength", "Xpecto soothing relief", "Desgen DM", "Gencontuss", "NoHist DM", "EndaCof DM", "LoHist DM", "G-zyncof", "G-tusicof", "Tusicof", "G-tron Pediatric Drops", "Brompheniramine Maleate, Pseudoephedrine Hydrochloride and Dextromethorphan Hydrobromide", "Healthy Accents Tussin CF", "Daytime Cold and Flu", "Dometuss-DM", "Dometuss-dmx", "Childrens mucus relief", "Sound Body Cold and Flu Relief", "Sound Body Cold and Flu Relief", "Sound Body Cold and Flu Relief", "Healthy Accents Tussin DM Adult Sugar Free", "Sound Body Cold and Flu Relief", "Sound Body Cold and Flu Relief DayTime", "Childrens Plus Multi Symptom Cold", "Being Well Adult Cough Relief DM", "Cough Cold", "Daytime Cold and Flu Multi symptom relief", "NiteTime Cold/Flu, Multi-Symptom Relief", "Mucus Relief DM Max Maximum Strength", "Daytime Severe Cold Nighttime Cold and Flu", "Childrens Cold and Cough Relief", "Severe Tussin CF", "Circle K Daytime Cold and Flu", "Circle K Daytime Cold and Flu", "Circle K Daytime Cold and Flu", "Circle K Daytime Cold and Flu", "Circle K Daytime Cold and Flu", "Nighttime Hbp", "Day and Night Sinus Relief Maximum Strength", "Day and Night Sinus Relief Maximum Strength", "Night Time Cough", "Rycontuss Cherry Flavor", "Cold and Flu Nighttime", "COLD FLU and SORE THROAT RELIEF", "DG Day Time Cold and Flu Formula and Night Time Cold and Flu Formula", "DG Day Time Cold and Flu Formula and Night Time Cold and Flu Formula", "Nighttime Cold and Flu cherry", "Tussin Multi Symptom Cold CF Adult", "DayQuil Severe", "Cold and Flu Relief Daytime", "Severe sinus Congestion Relief", "Day Time Cold and Flu non drowsy", "Severe Sinus Congestion Allergy and Cough Formula", "CVS Daytime COLD and FLU RELIEF and Nighttime COLD and FLU RELIEF", "CVS Daytime COLD and FLU RELIEF and Nighttime COLD and FLU RELIEF", "Nighttime Cold and Flu original", "Night Time Severe Cold and Flu Relief", "Daytime Cold and Flu Non drowsy", "Tussin CF Adult Multi Symptom Cold", "Night Time Cough cherry", "Leader Nighttime Severe Cold and Flu", "Tussin DM Cough and Chest Congestion", "Q Tussin DM", "Mucus Relief Cough and Congestion DM", "Cold Relief Maximum Strength / Day Time", "Daytime Cold and Flu and Nighttime Cold and Flu", "Daytime Cold and Flu and Nighttime Cold and Flu", "DAY Cold and Flu Plus and NIGHTTIME Cold and Flu Plus", "DAY Cold and Flu Plus and NIGHTTIME Cold and Flu Plus", "Day and Night Cold and Flu Formula", "Day and Night Cold and Flu Formula", "Tussin DM", "Daytime Severe Cold Multi-symptom", "Severe sinus Congestion Relief", "Cold, Flu and Sore Throat", "Chest Congestion and Cough HBP", "COLD FLU and SORE THROAT RELIEF", "Cold and Flu Severe", "Mucinex DM", "Daytime Severe Cold and Flu Relief", "Nighttime Cold and Flu", "Tussin DM Adult cough and chest congestion", "Nighttime Cough", "Sever Daytime Cold and Flu and Sever Nighttime Cold and Flu", "Sever Daytime Cold and Flu and Sever Nighttime Cold and Flu", "Rexall DM Cough and Congestion Relief", "Equate Tussin DM Max", "Equate Daytime", "Equate Daytime Severe", "Equate Day time cold and flu multi symptom relief", "Equaline tussin cough and chest congestion dm max", "Cold and Flu Relief Severe Daytime", "Daytime Nitetime", "Daytime Nitetime", "Daytime Severe Cold And Cough", "Maximum Strength Night Time Cold and Flu Relief", "Multi-Symptom Severe Cold", "Severe Cold and Flu", "Mucinex Fast-Max SEVERE COLD", "Nitetime", "Severe Cold", "Cold Relief Multi Symptom", "Daytime", "Good Neighbor Pharmacy Night Time", "Fast Mucus Relief", "Tussin DM Max", "Good Neighbor Pharmacy Cold and Cough", "Alka-Seltzer Plus Severe Cold and Flu", "Daytime Severe Cold and Flu", "Good Neighbor Pharmacy Tussin CF", "Good Neighbor Pharmacy Day Time", "Circle K Cold", "Good neighbor pharmacy mucus relief", "NightTime", "Good Neighbor Pharmacy Tussin DM", "Multi-Symptom Mapap Cold Formula", "Nite Time multi symptom cold/flu", "Alka-Seltzer Plus Cold Night", "Fast Mucus Relief", "Alka-Seltzer Plus Cold and Cough", "DayTime NiteTime Severe", "DayTime NiteTime Severe", "Good Neighbor Pharmacy Day Time Cold and Flu", "Cold and Flu Relief Multi-Symptom, DayTime", "Childrens Mucus Relief Cough", "Good Neighbor Pharmacy Severe Day Time", "Cold Multi Symptom", "Night Time Day Time", "Night Time Day Time", "Daytime Cold and Flu Non Drowsy", "Cold and Flu Nighttime", "Lil Drug Store Nighttime Cold and Flu", "Cold and Flu Nighttime", "Lil Drug Store Nighttime Cold and Flu", "Lil Drug Store Nighttime Cold and Flu", "Tussin DM Adults", "Night Time Cold and Flu Relief Multi Symptom", "Daytime Cold and Flu Non Drowsy", "Night Time Cold and Flu Relief Multi Symptom", "Daytime Nighttime Cold Flu Relief", "Daytime Nighttime Cold Flu Relief", "Primary Health - Fast Maximum Cold, Flu and Sore Throat Relief", "COLD and FLU Day Time Multi-Symptom Relief", "Day Time COLD and FLU non-drowsy", "Childrens Cold, Cough and Sore Throat", "Night Time Cold and Flu Original", "Daytime Severe Cold and Cough", "Auro Mucus - Childrens Cold, Cough and Sore Throat", "AuroMucus - Fast Maximum Severe Congestion and Cough", "AuroQuil COLD and FLU Day Time Multi-Symptom Relief", "Tussin Peak Cold Cough plus Chest Congestion DM", "Adult Tussin DM Cough Plus Chest Congestion DM", "Adult tussin Peak Cold Multi-Symptom Cold", "NIGHT TIME COLD and FLU CHERRY", "Night Time Cough Cherry", "AuroQuil Severe Cold and Flu Nighttime Relief", "Nighttime Cold and Flu", "Adult Tussin CF Multi-Symptom Cold", "AuroQuil Severe Cold and Flu Daytime Relief", "AuroQuil COLD and FLU Nighttime Relief", "Cold and Flu Relief Multi-Symptom", "Cold and Flu Relief Multi-Symptom", "COUGH Nighttime Cough Relief", "COLD and FLU Day Time Multi-Symptom Relief", "COLD and FLU Nighttime Relief", "Fast Acting Cold, Flu and Sore Throat Relief", "Fast Acting Cough Relief DM", "Auroflu Day Time Severe Cold and Cough", "Topcare Day Time Cold and Flu Relief Multi Symptom Relief", "Mucinex Fast-Max Severe Cold", "Topcare Nite Time Cough", "Good Neighbor Pharmacy Severe Night Time", "CVS - Childrens Mucus Relief Cough, Cold and Sore Throat", "Cold and Flu Nighttime Relief", "Topcare tussin dm sugar free cough and chest congestion", "COLD and FLU Nighttime Relief", "COLD and FLU Nighttime Relief", "Childrens Daytime Cold and Cough", "Topcare Day Time Cold and Flu Severe", "Childrens Cough and Chest Congestion DM", "Mucus Relief Maximum StrengthCold Flu and Sore Throat", "Night Time Cold and Flu Relief Multi Symptom", "Childrens Cough and Cold CF", "good neighbor pharmacy tussin CF Max", "AuroQuil Cold and Flu Nighttime Relief", "Mucus Relief DM Extended Release Caplets", "Daytime Nighttime Cold Flu Relief", "Daytime Nighttime Cold Flu Relief", "Good Neighbor Pharmacy Mucus Relief Severe Cold Cold and Flu Night Time", "Topcare Nite Time Cold and Flu Relief", "DayTime Cold and Flu Non Drowsy", "Good Neighbor Pharmacy Mucus Relief Severe Cold", "Adult Tussin Maximum Strength Nighttime Cough DM", "Good Neighbor Pharmacy Childrens Mucus Relief", "Equate Adult Tussin DM Max", "Mucus Relief DM", "Cold Relief Multi-Symptom", "Good Neighbor Pharmacy Tussin DM Max", "Night Time Cold and Flu Relief Multi Symptom", "Tussin Peak Cold Maximum Strength Cough plus Chest Congestion DM", "Daytime Cold and Flu", "Mucus Relief DM Extended Release Caplets", "Topcare Day Time Nite Time Cold and Flu", "Topcare Day Time Nite Time Cold and Flu", "Mucus Relief DM", "Topcare Nite Time Cold and Flu Relief", "Daytime Nighttime Cold and Flu Relief Multi-Symptom", "Daytime Nighttime Cold and Flu Relief Multi-Symptom", "Topcare Tussin DM Max", "Daytime and Nighttime Cough Relief", "Daytime and Nighttime Cough Relief", "Topcare Nite Time Cold and Flu", "Good Neighbor Pharmacy Day Time Severe", "Topco tussin cf max", "Childrens Mucus Relief Cough Cherry", "Severe Cold and Flu", "Mucus Relief DM Maximum Strength", "Cold Max Nighttime", "Nighttime Daytime Cough", "Nighttime Daytime Cough", "Tukol Cough and Congestion", "Topcare Cold and Flu", "Topcare Cold and Flu", "Daytime Cold and Flu", "Dibromm Cold and Cough Childrens", "Childrens Mucus Relief Cough Cherry", "Cough and Chest Congestion DM", "Daytime Nighttime Cold and Flu", "Daytime Nighttime Cold and Flu", "Childrens Mucus Relief Multi Symptom Cold", "Daytime Severe Cold and Flu Relief", "Night time cold and flu", "Fast Maximum Severe Congestion and Cough", "Cold and Flu", "Aurotussin Maximum Strength Daytime and Nighttime Cough Relief", "Aurotussin Maximum Strength Daytime and Nighttime Cough Relief", "tussin severe multi symptom cough cold plus flu CF MAX", "Cough childrens mucus relief", "Severe Cold and Flu Relief Nighttime", "Nighttime Cough all night cough relief", "Night time cold and flu", "WalTussin DM Max", "WalTussin DM Max", "Childrens Plus Multi-Symptom Cold Grape with PE", "Flu Relief Therapy Day Time", "Wal Tussin DM Adult Cough and Chest Congestion", "Tukol Max Action Cold Sore Throat and Cough", "Night Time Cold and Flu ReadyInCase", "Daytime Nighttime Cold and Flu", "Daytime Nighttime Cold and Flu", "Cough", "Daytime Severe Cold and Flu Relief", "Topcare Tussin DM Max", "Tukol Max Action Severe Congestion and Cough", "Night Time Cough", "Day Time Cold and Flu Non Drowsy ReadyInCase", "Childrens Plus Cough and Runny Nose", "Cold and Flu", "NEXT Severe Cold, Flu and Sore Throate Night Max Strength", "DayQuil Severe Cold and Flu", "Daytime Nighttime Severe Cold and Flu", "Daytime Nighttime Severe Cold and Flu", "NightTime", "Topcare Day Time Cold and Flu", "Tussin Cough and Chest Congestion DM Max", "Nighttime Cold and Flu ReadyInCase", "Cold and Flu Nighttime D", "Tukol For Diabetics", "Cold and Flu Relief Nighttime", "Day Time Cold Multi-Symptom Cool Blast", "Topcare Nite Time Cold and Flu", "Daytime Nighttime Cold and Flu", "Daytime Nighttime Cold and Flu", "NyQuil Severe", "Topcare Tussin CF Max", "Tussin CF Multi Symptom Cold Adult", "Topcare Mucus Relief Severe Congestion and Cold", "Tussin Cough and Chest Congestion DM maximum strength", "Night Time", "Tussin DM Cough Nighttime Maximum Strength", "Tussin DM", "Tussin DM Cough and Chest Congestion Adult", "Tussin DM Cough and Chest Congestion sugar-free ReadyInCase", "Night Time Cough Relief", "Good Sense Severe Daytime Cold and Flu", "Daytime Cold and Flu Non Drowsy", "Night Time", "Topcare Nite Time Cold and flu relief", "Daytime Cold Flu multi Symptom", "Mucinex DM", "Night Time Cold and Flu", "Topcare Mucus Relief Cold Flu and Sore Throat", "Tussin Cough DM Sugar Free", "Tussin", "tussin cough and chest congestion DM", "Daytime Nighttime Cold and Flu Relief Multi-Symptom", "Daytime Nighttime Cold and Flu Relief Multi-Symptom", "DayTime", "Day Time", "Daytime Cold Flu multi Symptom", "Daytime Nighttime Cold and Flu Relief Multi-Symptom", "Daytime Nighttime Cold and Flu Relief Multi-Symptom", "Complete Cold Relief", "Mucus DM Extended-Release", "Mucus DM Extended Release", "Night time cold and flu multi symptom", "Mucus Relief DM", "Shoprite Day Calm Severe", "Nitetime Cold and Flu", "DG Health Childrens Mucus Relief Cough", "Dg Health Tussin", "SanaTos Day and Night Multi Symptom", "SanaTos Day and Night Multi Symptom", "Cough Plus Chest Congestion Adult DM Max", "Dg Health Cold and Flu Relief", "Night Time Cold and Flu Relief Multi Symptom", "ShopRite Adult Tussin", "DG Health tussin cf adult cough and cold", "Dg Health Cold Plus Flu Relief", "DG Health Cold and Flu Relief Daytime", "Cold and Flu Relief Multi-Symptom", "Cold and Flu Relief Multi-Symptom", "Night Time Cold and Flu Relief Multi Symptom", "DG Health Cold and Flu Relief", "Dg Health Cold and Flu Relief", "Dg Health Cold and Flu Relief", "DG Health Cold and Flu Relief", "Shoprite Adult Tussin", "Night Time Cold and Flu Relief Multi Symptom", "DG Health Tussin", "DG Health night time cold and flu relief", "Sanatos Nighttime Multi Symptoms", "shop rite Day Severe Cold Night Cold and Flu", "shop rite Day Severe Cold Night Cold and Flu", "Childrens Multi-Symptom Cold and Fever Relief", "Mixed Berry Sore Throat Lozenges", "SanaTos Childrens Mucus Relief Cough", "Tussin DM Max", "Daytime Cold and Flu", "Antigrip", "Childrens Plus Cough and Runny Nose", "Dometuss", "Nighttime Cold and Flu", "Mucus Relief Cold Flu and Sore Throat Maximum Strength", "Fast Acting Mucus Relief Maximum Strength Severe Cough and Congestion", "Day Time Severe", "Childrens Multi-symptom Cold", "Childrens Plus Cough and Runny Nose", "Childrens Plus Flu", "Daytime Severe", "Childrens Plus Multi Symptom Cold DYE FREE", "Childrens Plus Multi Symptom Cold", "Daytime Nighttime Cold and Flu Relief", "Daytime Nighttime Cold and Flu Relief", "Mixed Berry Throat and Cough Lozenges", "Tussin DM", "CounterAct Day", "Sanatos Multi Symptom Daytime", "Severe Nighttime Cold and Flu Relief", "Cold and Flu Relief", "Day Time", "ShopRite Day Calm Severe", "Mucus Relief DM Max Maximum Strength Fast Acting", "Night Time", "Cold and Flu Relief Multi symptom, Nighttime", "Sugar Free Cough and Chest Congestion Relief Adult", "Leader Tussin DM", "Leader Daytime Cold and Flu", "Mucus Relief Congestion Cough Maximum Strength Severe Congestion and Cough", "CareOne Cold Flu and sore throat", "Night Time Cold and Flu Relief", "Severe Cold and Cough Relief Daytime", "Good Sense Tussin CF", "CareOne DayTime Cold and Flu", "Cold Flu and Sore Throat Maximum Strength", "CareOne Night TIme Cold and Flu", "Daytime Nighttime Severe Cold and Flu Relief", "Daytime Nighttime Severe Cold and Flu Relief", "Good Sense Daytime", "Circle K Nighttime Cold and Flu", "Circle K Nighttime Cold and Flu", "Circle K Nighttime Cold and Flu", "Circle K Nighttime Cold and Flu", "Circle K Nighttime Cold and Flu", "Severe Cold and Flu Relief Daytime", "Good Sense Daytime non drowsy cold and flu", "CareOne Daytime Nighttime Cold and Flu", "CareOne Daytime Nighttime Cold and Flu", "CareOne Nighttime Cold and Flu", "Leader Tussin DM Cough Plus Chest Congestion DM", "Lil Drug Store Tylenol Cold plus Flu Severe", "Good Sense Tussin DM", "DayTime and NiteTime", "DayTime and NiteTime", "SanaTos Children Cough and Congestion Cherry", "Good Sense Cold Max", "Leader Tussin DM", "Good Sense Cold Head Congestion Severe", "Leader Tussin CF", "Night Time Cold and Flu Relief", "Careone Tussin DM", "Good Sense Childrens Mucus Relief Cough", "CareOne Tussin DM cough plus chest congestion", "Nite Time Cold and Flu", "Smart Sense Cough and Chest Congestion", "DG Health Cold and Flu Relief", "Rexall Night Time Cold and Flu", "Mucus Relief DM Maximum Strength", "Maximum Strength Congestion and Headache", "Day Severe Cold Night Cold and Flu", "Day Severe Cold Night Cold and Flu", "Cold and Flu Nighttime", "Mucus Relief Severe Congestion Cough Night Time Cold and Flu Maximum Strength", "Dg Health Childrens Mucus Relief", "DM Cough and Congestion Relief Adult non-Drowsy Sugar Free", "Cold and Flu Relief Daytime", "Severe cold and flu Nighttime", "Daytime Nighttime Cold and Flu", "Daytime Nighttime Cold and Flu", "Leader Daytime Severe Cold and Flu", "CareOne NightTime Cough", "CareOne Tussin DM cough plus chest congestion", "Mixed Berry Sore Throat and Cough Lozenge", "CareOne Cold plus Flu Severe", "Topcare Day Time Nite Time Cold and Flu Relief", "Topcare Day Time Nite Time Cold and Flu Relief", "Smart Sense Severe Cold and Flu NightTime", "Good Sense Childrens Mucus Relief", "Good Sense Mucus Relief cold flu and sore throat", "Equaline tussin adult", "Equaline Childrens Mucus Relief", "Equaline Tussin", "Mucus Relief Severe Congestion and Cough Maximum Strength", "Smart Sense Daytime Nighttime Cold and Flu", "Smart Sense Daytime Nighttime Cold and Flu", "Equaline Tussin Multi Symptom", "Good Sense Severe NightTime Cold and Flu", "Good Sense Tussin DM Cough and Chest Congestion", "Equaline Daytime Cold and Flu Relief", "Cold and Flu Relief", "Smart Sense DayTime", "Smart Sense daytime cold and flu", "Smart Sense cold flu and sore throat", "Childrens Mucus Relief Chest Congestion Plus Cough", "Good Sense Severe Cold", "DAY TIME COLD and FLU FORMULA", "Tussin CF", "Smart Sense nighttime cold and flu", "Dg Health Cold and Flu Relief Night Time", "Vanacof DMX", "Severe Cough and Congestion Maximum Strength", "Good Sense Tussin DM Max", "Cold Multi Symptom", "Smart Sense Severe Cold", "Theraflu Cough Relief", "Promethazine DM", "Harris Teeter DayTime", "Harris Teeter Tussin", "Harris Teeter NightTime Cold and Flu", "Good Sense Tussin CF Max", "Daytime Nighttime Cold Flu Relief", "Daytime Nighttime Cold Flu Relief", "Robafen", "Mucus Relief Cold Flu and Sore Throat Maximum Strength", "Daytime Nighttime Cold Flu Relief", "Daytime Nighttime Cold Flu Relief", "Harris Teeter Tussin", "Tussin CF Adult Maximum Strength", "Humana Pharmacy Daytime Cold and Flu Relief", "Daytime Cold and Flu", "Harris Teeter Tussin", "Daytime Cold and Flu Relief Multi-Symptom", "Daytime Cold and Flu Relief", "Core Values Night Time Relief", "NIGHTTIME COLD and FLU", "Up and Up Daytime Cold and Flu", "Up and Up Nighttime Cold and Flu", "NIGHT TIME COLD and FLU FORMULA", "Acetaminophen Dextromethorphan HBr Guaifenesin Phenylephrine HCl", "Good Sense Night Time", "Nighttime Cold and Flu Relief Multi Symptom", "Daytime SEVERE COLD and FLU", "Up and Up Nighttime Cough Control DM Max", "Nighttime SEVERE COLD and FLU", "Up and Up Daytime Severe Cold Nighttime Cold and Flu", "Up and Up Cough Plus Chest Congestion", "Up and Up DM Max Cough Plus Chest Congestion", "Mucus Relief Severe Congestion and Cough Maximum Strength", "Up and Up Cold Flu Relief Day Night", "Up and Up Cold Flu Relief Day Night", "Nighttime Cough Relief", "Cold and Flu Relief Nighttime Multi Symptom", "Up and Up Fast Mucus Relief Severe Cold", "Up and Up Daytime Nighttime Cold and Flu", "Up and Up Daytime Nighttime Cold and Flu", "Up and Up Mucus Relief", "Good Sense Severe Daytime Cold and Flu", "Good Neighbor Pharmacy Cold Multi Symptom", "Guaifenesin DM", "Daytime cold and flu relief", "Signature Care Tussin", "Childrens Dibromm Cold and Cough", "Daytime Flu Relief Therapy Severe Cough and Cold", "Mucus Relief DM Maximum Strength", "H E B MAX SEVERE CONGESTION and COUGH Maxium Strength", "Cold and Flu Daytime", "Mucus Relief Severe Congestion and Cough Maximum Strength", "Childrens Plus Multi Symptom Cold", "Maximum Strength DM MAX", "Childrens Plus Flu", "Signature Care Tussin", "Cold and Flu Relief Nighttime", "Childrens Plus Cough and Runny Nose", "Cough Relief Nighttime", "Night Time Cold and Flu Relief Multi Symptom", "Equaline Daytime Severe Cold and Flu Relief", "NightTime Cold and Flu Multi Symptom", "Cold and Flu Nighttime Relief", "Adult Tussin Cough and Chest Congestion DM", "Cough and Chest Congestion DM Max", "Tussin Multi Symptom Cold CF Adult", "Mucinex Fast-Max Cold, Flu and Sore Throat", "Good Neighbor Pharmacy tussin dm max adult", "NightTime Cold and Flu Multi Symptom", "Night Time Cold and Flu Relief Multi Symptom", "Nighttime Cough Relief", "Equaline Mucus Relief", "Diabetic Tussin DM Maximum Strength", "Daytime Non Drowsy", "Cold and Flu Nighttime Relief", "Adult Tussin Cough and Chest Congestion DM Sugar Free", "Maximum Strength Mucinex Sinus-Max Pressure, Pain and Cough", "Cold and Flu Severe", "DayTime/NiteTime Severe Cold and Flu Maximum Strength", "DayTime/NiteTime Severe Cold and Flu Maximum Strength", "Geri-tussin DM", "Mucinex Fast-Max Cold, Flu and Sore Throat", "Mucus Relief DM", "Cold and Flu Daytime, Nighttime, Maximum Strength", "Cold and Flu Daytime, Nighttime, Maximum Strength", "Smart Sense Multi Symptom Cold", "Mucinex Fast-Max Cold and Flu", "Mucinex Fast-Max Severe Congestion and Cough", "Topcare Nite Time Day Time Cold and Flu Relief", "Topcare Nite Time Day Time Cold and Flu Relief", "Guaiasorb DM", "Cold and Flu Relief Multi-Symptom", "Childrens Robitussin Nighttime Cough Long-Acting DM", "Mucinex Fast-Max Cold, Flu and Sore Throat Clear and Cool", "Mucus Multi Symptom Cold Relief Childrens", "Cold and Flu Relief Daytime", "Mucus Relief DM Maximum Strength", "Mucinex Fast-Max Cold, Flu and Sore Throat", "Mucus Relief Cold Flu and Sore Throat Maximum Strength", "Maximum Strength Mucinex Fast-Max Cold and Flu", "Flu Relief Therapy Daytime", "Mucus Relief Cough Childrens", "Daytime", "Dextromethorphan HBr and Guaifenesin", "Nighttime Cold and Flu Relief Multi-Symptom", "Acetaminophen, Guaifenesin, Dextromethorphan HBr, Phenylephrine HCl", "DAY TIME Cold Flu Medicine", "Guaifenesin, Dextromethorphan Hbr", "Day Severe Cold and Night Cold and Flu Maximum Strength", "Day Severe Cold and Night Cold and Flu Maximum Strength", "Daytime Nitetime Cold and Flu", "Daytime Nitetime Cold and Flu", "Severe sinus Congestion Relief", "Mucus Relief DM", "Nite Time Cold and Flu", "Mucus Relief Severe Congestion and Cough Maximum Strength", "Diabetic Tussin Nighttime Cold and Flu", "Nitetime Cold and Flu", "COLD FLU and SORE THROAT RELIEF", "COLD FLU and SORE THROAT RELIEF", "Mucinex Fast-Max Severe Congestion and Cough Clear and Cool", "Nighttime Cold and Flu", "DAY Cold and Flu Plus and NIGHTTIME Cold and Flu Plus", "DAY Cold and Flu Plus and NIGHTTIME Cold and Flu Plus", "DayTime Cold and Flu", "Daytime Cold and Flu", "Daytime Mucus Relief Severe Cold/Nighttime Mucus Relief Cold and Flu", "Severe Cold and Cough Relief Daytime", "Maximum Strength Mucinex Fast-Max Day Time Cold and Flu and Maximum Strength Mucinex Fast-Max Night Time Cold and Flu", "Good Sense Severe Day Time Cold and Flu", "Health Mart daytime", "Cold and Flu Nighttime", "Severe Cold and Flu Daytime Non Drowsy Nighttime", "Severe Cold and Flu Daytime Non Drowsy Nighttime", "Multi-symptom Nitetime", "Severe Cold Multi Symptom", "Mucus Relief Cold Flu and Sore Throat Maximum Strength", "Mucus Relief Cough Childrens", "Daytime Nighttime Cold Flu Relief", "Daytime Nighttime Cold Flu Relief", "Multi-symptom Daytime", "COLD and FLU DAYTIME MAXIMUM STRENGTH NON-DROWSY SEVERE", "Mucus Relief DM", "Daytime Nighttime Cold and Flu Relief Multi-Symptom", "Daytime Nighttime Cold and Flu Relief Multi-Symptom", "ACETAMINOPHEN DEXTROMETHORPHAN HYDROBROMIDE and DOXYLAMINE SUCCINATE", "Mixed Berry Sore Throat and Cough Lozenge", "Daytime Cold and Flu Relief", "Mucus Relief Severe Congestion and Cough Maximum Strength", "Multi-symptom Daytime", "Daytime Severe Cold and Cough Relief", "Mucus Relief DM", "Non-Drowsy Daytime Multi Symptom Cold and Flu Relief", "Severe Sinus Congestion and Cough Daytime Non-drowsy / Nightime", "Severe Sinus Congestion and Cough Daytime Non-drowsy / Nightime", "Severe Cold and Flu Relief Daytime", "ACETAMINOPHEN DEXTROMETHORPHAN HYDROBROMIDE and PHENYLEPHRINE HYDROCHLORIDE", "Cold and Flu Nighttime", "Tusnel-DM Pediatric", "Rompe Pecho CF", "Stona-S", "Tussin Nighttime Cough DM Maximum Strength", "Stona Cough", "Night Time Cold and Flu Relief Multi Symptom", "Children Cough and Cold", "Guaifenesin and Dextromethorphan HBr", "Triponel", "Stona", "Guaifenesin and Dextromethorphan HBr", "Night Time Cough", "Cold and Cough Day Time Childrens", "Severe cold and flu Nighttime", "Nighttime Multi Symptom Cold and Flu Relief", "Severe Sinus Congestion Allergy and Cough Formula", "Dextromethorphan Hbr, Guaifenesin", "DayTime Maximum Strength Cold and Flu", "Nighttime Cold and Flu Relief", "Daytime Cold and Flu Multi-symptom Relief", "DayTime Cold and Flu", "Cold and Flu Multi-symptom Relief/cold and Flu Nighttime Relief", "Cold and Flu Multi-symptom Relief/cold and Flu Nighttime Relief", "Severe sinus Congestion Relief", "COLD FLU and SORE THROAT RELIEF", "Nighttime Cold and Flu", "Maximum Strength Cough Plus Chest Congestion DM", "Severe Nighttime Cold and Flu", "NightTime Maximum Strength Cold and Flu", "Daytime Cold and Flu", "Mucus Relief Cold Flu Sore Throat Maximum Strength", "NIGHTTIME COLD and FLU", "DAYTIME COLD and FLU", "Tussin DM Cough and Chest Congestion", "DayTime Severe Cold and Flu Relief", "Cold, Flu and Sore Throat", "Nighttime Severe Cold and Flu Relief", "Sunmark Tussin DM Max", "DDM Day time and Nite time cold and flu", "DDM Day time and Nite time cold and flu", "DAY TIME Cold Flu Medicine", "DAY TIME and NIGHT TIME COLD and FLU FORMULA", "DAY TIME and NIGHT TIME COLD and FLU FORMULA", "CVS Daytime COLD and FLU RELIEF and Nighttime COLD and FLU RELIEF", "CVS Daytime COLD and FLU RELIEF and Nighttime COLD and FLU RELIEF", "Chest Congestion and Cough HBP", "Tussin DM Cough and Chest Congestion", "COLD FLU and SORE THROAT RELIEF", "Lil Drug Store Cold Relief", "Lil Drug Store Cold Relief", "Health Mart Adult Tussin", "Maximum Strength Nighttime Cold/Flu Relief", "Mucus Relief DM", "Severe sinus Congestion Relief", "Daytime and Nighttime Cold and Flu", "Daytime and Nighttime Cold and Flu", "Mucus Relief DM Extended Release Caplets", "Mucus Relief DM", "Alka-Seltzer Plus Maximum Strength Cough and Mucus DM", "Good Neighbor Pharmacy Tussin dm", "Sun Mark Mucus Relief Cough Childrens", "Alka-Seltzer Plus Severe Sinus Cough and Cold", "Vicks DayQuil and Vicks NyQuil Severe Cold and Flu", "Vicks DayQuil and Vicks NyQuil Severe Cold and Flu", "Vicks DayQuil and Vicks NyQuil Severe Cold and Flu", "Vicks DayQuil and Vicks NyQuil Severe Cold and Flu", "Vicks DayQuil and Vicks NyQuil Severe Cold and Flu", "Vicks DayQuil and Vicks NyQuil Severe Cold and Flu", "Vicks DayQuil HBP", "Cold and Flu Severe", "Vicks Formula 44 Nighttime Cough and Cold", "Vicks DayQuil Severe Cold and Flu", "Vicks DayQuil Severe and Vicks NyQuil Severe Cold and Flu", "Vicks DayQuil Severe and Vicks NyQuil Severe Cold and Flu", "Vicks DayQuil and Vicks NyQuil Cold and Flu Multi-Symptom Relief/Cold and Flu Nighttime Relief", "Vicks DayQuil and Vicks NyQuil Cold and Flu Multi-Symptom Relief/Cold and Flu Nighttime Relief", "Vicks NyQuil Cold and Flu Nighttime Relief", "Vicks DayQuil Cold and Flu Multi-Symptom Relief", "Vicks DayQuil and Vicks NyQuil Cold and Flu Multi-Symptom Relief/Cold and Flu Nighttime Relief", "Vicks DayQuil and Vicks NyQuil Cold and Flu Multi-Symptom Relief/Cold and Flu Nighttime Relief", "Vicks DayQuil and Vicks NyQuil Cold and Flu Multi-Symptom Relief/Cold and Flu Nighttime Relief", "Vicks DayQuil and Vicks NyQuil Cold and Flu Multi-Symptom Relief/Cold and Flu Nighttime Relief", "Vicks DayQuil and Vicks NyQuil Cold and Flu Multi-Symptom Relief/Cold and Flu Nighttime Relief", "Vicks DayQuil and Vicks NyQuil Cold and Flu Multi-Symptom Relief/Cold and Flu Nighttime Relief", "Daytime Nighttime Cold and Flu Relief Multi-Symptom", "Daytime Nighttime Cold and Flu Relief Multi-Symptom", "Wal Flu Severe", "DayQuil and Nyquil Severe plus Vicks VapoCool Cold and Flu", "DayQuil and Nyquil Severe plus Vicks VapoCool Cold and Flu", "Day and Night Severe Sinus Congestion and Cough Maximum Strength", "Day and Night Severe Sinus Congestion and Cough Maximum Strength", "Cooling Severe Nighttime", "Severe sinus Congestion Relief", "Cooling Severe Daytime Cooling Severe Nighttime", "Cooling Severe Daytime Cooling Severe Nighttime", "Equate Health Non Drowsy DAY Cold and Flu Plus and NIGHTTIME Cold and Flu Plus", "Equate Health Non Drowsy DAY Cold and Flu Plus and NIGHTTIME Cold and Flu Plus", "Daytime Cold Flu Non Drowsy", "Nighttime Multi Symptom Cold and Flu Relief", "Mucus Relief DM Maximum Strength", "Mucus Relief DM", "Alka-Seltzer Plus Day Severe Cold Plus Flu", "Nivanex DMX", "Alka-Seltzer Plus Night Severe Cold and Flu", "Maximum strength Tussnex FM DM Max", "Childrens Tussnex", "Mucus Relief DM Maximum Strength", "Dr. Cocoa Daytime Cough and Cold", "Childrens Metapp Daytime", "Nighttime Cold and Flu Relief", "Maximum Strength Cold Flu and Sore Throat", "Tussnex FM Cold, Flu and Sore Throat", "DayTime Cold Flu Non Drowsy", "Mucinex DM", "TRISPEC DMX Cough Suppressant Expectorant Peach Flavor", "Mucus Relief DM", "Wal Flu Severe Cold", "Alka-Seltzer Plus Day and Night Severe Cold and Flu", "Alka-Seltzer Plus Day and Night Severe Cold and Flu", "Multi Symptom Cold", "Multi Symptom Cold", "Dextromethorphan HBr and Guaifenesin", "Cough and Cold XL3 Xtra", "Rabofen DM", "DELTUSS DMX Cough Suppressant Nasal Decongestant Antihistamine GRAPE Flavor", "Childrens Tussnex Multi-symptom cold", "Good Sense Tussin DM", "Tussnex FM Severe cough and congestion", "Alahist CF", "Polytussin DM", "Cold Multi-Symptom Severe Day Time", "Alka-Seltzer Plus Cold Day and Night", "Alka-Seltzer Plus Cold Day and Night", "Cooling Severe Daytime", "TRISPEC PSE Cough Suppressant Expectorant Nasal Decongestant GRAPE Flavor", "Cooling Severe Nighttime", "Cough and Cold XL3 Xtra", "Poly-Vent DM", "Sunmark Nite Time", "Cough and Cold XL3 Xtra", "Promethazine DM", "Equate Nighttime Cold and Flu", "DEXTROMETHORPHAN HYDROBROMIDE, Guaifenesin, and PHENYLEPHRINE HYDROCHLORIDE", "Dextromethorphan Hydrobromide, Guaifenesin, Phenylephrine Hydrochloride", "Lil Drug Store NyQuil Severe Cold and Flu, Max Strength", "Mucinex DM", "Rugby Mucus Relief DM", "Mucinex DM", "Good Neighbor Pharmacy Mucus DM", "Histex-DM", "Mucus Relief Cough", "M-end Dmx", "Guaifenesin and Dextromethorphan HBr", "Guaifenesin and Dextromethorphan HBr", "Berro y Cebolla DM", "Breacold Children", "Mucus Relief DM", "Mucus DM Extended Release", "Maximum Strength Mucus DM Extended Release", "Mucus DM", "Maximum Strength Mucus Relief DM", "TexaClear Kids Cough and Cold", "Mucus Relief DM", "Mucus Relief DM", "Mucus Relief DM", "Maximum Strength Mucus Relief DM", "Texaclear Daytime Cough Cold/flu", "Bisolvine Aloe-Miel", "Mucus Relief DM", "Daytime Mucus Relief Severe Cold and Nighttime Cold and Flu Maximum Strength", "Daytime Mucus Relief Severe Cold and Nighttime Cold and Flu Maximum Strength", "Mucus Relief DM", "mucus relief DM", "Mucus Relief DM", "Health Mart Day Time Cold and Flu Night Time Cold and Flu", "Health Mart Day Time Cold and Flu Night Time Cold and Flu", "Guaifenesin and Dextromethorphan HBr", "SUDAFED PE Head Congestion Plus Flu Severe", "Day Time Multi-Symptom Flu Cold Medicine", "Mucus Relief DM MAXIMUM STRENGTH", "Sudafed PE Pressure Plus Pain Plus Cold", "Maximum Strength Mucus Relief DM", "Mucus Relief DM MAXIMUM STRENGTH", "Mucus Relief DM", "Mucus Relief DM", "Mucus Relief DM", "Maximum Strength Mucus-DM", "Mucus Relief DM", "Guaifenesin and Dextromethorphan HBr", "Mucus Relief DM Expectorant and Cough Suppressant", "Guaifenesin and Dextromethorphan HBr", "Night Time Cold and Flu Relief Multi Symptom", "Mucus Relief DM Expectorant and Cough Suppressant Maximum Strength", "Tukol Max Action DM Max", "Leader Childrens Mucus and Cough Relief", "Daytime Nighttime Cold Flu Relief", "Daytime Nighttime Cold Flu Relief", "Cold Relief Severe, Multi-symptom", "Tylenol Cold Plus Flu Severe", "Nighttime Cold and Flu", "Mucus Relief DM MAX", "Maximum Strength Mucus Relief Severe Congestion and Cough Cooling Menthol", "Diabetic Tussin DM Maximum Strength", "Guaifenesin DM", "Diabetic Tussin Nighttime Cold and Flu", "Diabetic Tussin DM", "meijer Maximum Strength Nighttime Cough DM", "Cold Multi-Symptom", "Cold Multi-Symptom", "Coricidin HBP Maximum Strength Flu", "Coricidin HBP Chest Congestion And Cough", "Nighttime Cough DM", "Resfridol Antitussive", "Tussin DM cough and chest congestion", "Sunmark Tussin CF", "Sun Mark Tussin DM cough and chest congestion", "Broncofin", "Cold and Flu Daytime, Nighttime, Multi-Symptom", "Cold and Flu Daytime, Nighttime, Multi-Symptom", "Cold and Flu Daytime, Nighttime, Multi-Symptom", "Cold and Flu Daytime, Nighttime, Multi-Symptom", "Health Mart Daytime", "Flu HBP Maximum Strength", "Mucus Relief DM", "Night Time Cold and Flu", "Flu HBP Maximum Strength", "Day Cold and Flu Night Cold and Flu", "Day Cold and Flu Night Cold and Flu", "Severe Cold and Flu Relief Daytime", "cough and cold relief HBP", "Nighttime Cold and Flu", "Nighttime Cold and Flu", "Topcare Day Time Cold and Flu", "Daytime Cold and Flu", "Guaifenesin and Dextromethorphan Hydrobromide", "Guaifenesin and Dextromethorphan Hydrobromide", "Mucus Relief ER DM Extended Release", "Severe Nighttime Cold and Flu", "Non Drowsy DAYTIME and NIGHTTIME Sinus Congestion and Cough Relief", "Non Drowsy DAYTIME and NIGHTTIME Sinus Congestion and Cough Relief", "Akin DM", "Severe Cold and Flu Daytime Non Drowsy Nighttime", "Severe Cold and Flu Daytime Non Drowsy Nighttime", "Mucus Relief DM Cough", "Cold and Cough", "Cooling Severe Daytime", "Core Values Tussin CF", "Walgreens Maximum Strength Non-Drowsy Day and Night Sinus and Cold", "Walgreens Maximum Strength Non-Drowsy Day and Night Sinus and Cold", "Sunmark Cold and Flu Severe", "Core Values Tussin DM", "Cough and Cold HBP", "Cold-Flu Relief Multi Symptom", "Daytime Cold, Nighttime Cold multi-symptom", "Daytime Cold, Nighttime Cold multi-symptom", "Cough and Cold HBP", "Brompheniramine Maleate, Pseudoephedrine Hydrochloride and Dextromethorphan Hydrobromide", "Rompe Pecho DM", "Circle K Daytime Cold and Flu", "Circle K Nighttime Cold and Flu", "Circle K Nighttime Cold and Flu", "Cold and Flu Relief Severe", "Rompe Pecho Max Multi Symptoms", "Mucinex Fast-Max DM Max", "Rompe Pecho SF FLU", "Alka-Seltzer Plus Multi-Symptom Cold Day and Night", "Alka-Seltzer Plus Multi-Symptom Cold Day and Night", "Sunmark Tussin DM Sugar Free", "Overnight Cold and Flu", "Cold and Flu Daytime Severe, Nighttime Severe", "Cold and Flu Daytime Severe, Nighttime Severe", "Pain Relief Non-Drowsy, Daytime", "Nighttime Cold and Flu Maximum Strength", "NightTime", "Cooling Severe Daytime Cooling Severe Nighttime", "Cooling Severe Daytime Cooling Severe Nighttime", "Bisolvine Children", "flu HBP Maximum Strength", "Defensolito Children Syrup", "Equaline Mucus DM", "Topcare childrens cold cough and sore throat", "Brompheniramine Maleate, Pseudoephedrine Hydrochloride, Dextromethorphan Hydrobromide", "Mucus Relief DMImmediate Release Immediate Release", "Cold/Flu Multi-Symptom Relief Daytime/Nighttime", "Multi-Symptom Daytime Cold Rapid Release", "Nighttime Cold and flu Relief", "Daytime Cold and Flu Relief Non Drowsy", "Daytime and Nighttime Cold and Flu Relief", "Daytime and Nighttime Cold and Flu Relief", "Siltussin DM DAS Cough Formula", "Daytime Cold and Flu Non Drowsy", "Day Time Night Time Cold and Flu", "Day Time Night Time Cold and Flu", "Nighttime Cold and Flu", "Promethazine Hydrochloride and Dextromethorphan Hydrobromide", "Cold Formula Daytime Nighttime, Non-Aspirin, Multi-Symptom", "Cold Formula Daytime Nighttime, Non-Aspirin, Multi-Symptom", "Cough and Cold HBP", "Cold and Flu Relief Nighttime", "Cold and Flu Relief Nighttime", "Daytime Nighttime Cold and Flu Relief Multi-Symptom", "Daytime Nighttime Cold and Flu Relief Multi-Symptom", "Severe Cold Daytime", "Basic Care Daytime Cold and Flu", "COLD and FLU", "Non Drowsy DAY Cold and Flu Plus and NIGHTTIME Cold and Flu Plus", "Non Drowsy DAY Cold and Flu Plus and NIGHTTIME Cold and Flu Plus", "Cough and Cold HBP", "Wal Tussin DM Max", "Multi-symptom Nighttime", "Aquanaz", "Capmist DM", "Equaline Mucus DM", "Capron DMT", "COLD and FLU", "Cold Multi-Symptom Night-time", "Daytime Severe Cold And Flu Relief Maximum strength", "Multi-symptom Daytime", "Giltuss Total Release", "Cold and Flu Relief Nighttime", "Night Time Cold and Flue Relief", "Cough and Cold", "Multi-symptom Daytime", "Multi-symptom Daytime", "Mucus Relief DM", "Cold and Flu Daytime", "Day Time", "Severe Congestion and Cough", "Daytime Severe Cold and Flu", "Mucus Relief DM", "Cold and Flu DayTime", "Cold and Flu Severe", "Severe Congestion and Cold Relief Maximum Strength, Multi Symptom", "Daytime Nighttime Cold Flu Relief", "Daytime Nighttime Cold Flu Relief", "Flu HBP Maximum Strength", "Promethazine Hydrochloride and Dextromethorphan Hydrobromide", "DAYTIME and Nighttime Cold and Flu", "DAYTIME and Nighttime Cold and Flu", "Flu and Severe Cold and Cough Daytime", "multi-symptom cold relief Daytime, Nighttime", "multi-symptom cold relief Daytime, Nighttime", "Flu HBP Maximum Strength", "Up and Up Nighttime Severe Cold and Flu", "Vicks Jarabe Cough Congestion", "Childrens Novex Cold Plus Cough Plus Sore Throat", "Robafen", "Tussin", "Deconex Dmx", "DAYTIME and Nighttime Sinus Relief", "DAYTIME and Nighttime Sinus Relief", "Equate Nightime Cough", "Daytime Severe Cold and Cough", "AcetaFlu DayTime", "Cold and Flu DayTime, NightTime Severe", "Cold and Flu DayTime, NightTime Severe", "Daytime Severe", "AcetaFlu DayTime Effervescent", "Cepacol Extra Strength Sore Throat and Cough", "Nighttime Childrens Multi Symptoms Cold and Cough Multi-Symptom Relief", "Nighttime", "Daytime Severe Cold and Flu Relief Softgels", "Severe Nighttime Cold and Flu", "Brompheniramine Maleate, Pseudoephedrine Hydrochloride, and Dextromethorphan Hydrobromide", "Brompheniramine Maleate, Pseudoephedrine Hydrochloride, Dextromethorphan Hydrobromide", "Nite Time Day Time", "Nite Time Day Time", "Ed A-hist DM", "Childrens Delsym Cough Plus Chest Congestion DM and Delsym Cough Plus Cold Night Time", "Ed-A-hist DM", "Winco Foods Childrens Multi Symptom Cold", "CVS Mucus Relief DM Maximum Strength", "Daytime Cold and Flu", "Maximum Strength Severe Congestion Relief", "CVS Maximum Strength Severe Congestion and Cough", "CVS Maximum Strength Severe Congestion and Cough Overnight Cold and Flu Clear and cool", "CVS Maximum Strength Severe Congestion and Cough Overnight Cold and Flu Clear and cool", "Walgreens Maximum Strength Non Drowsy Day and Night Cold and Flu", "Walgreens Maximum Strength Non Drowsy Day and Night Cold and Flu", "Maximum Strength Congestion and Headache", "Severe Cold and Flu Daytime Non Drowsy Nighttime", "Severe Cold and Flu Daytime Non Drowsy Nighttime", "Daytime Cold and Flu", "Severe Cold Maximum Strength, Multi-Symptom", "Daytime Mucus Relief Severe Cold and Nighttime Cold and Flu Maximum Strength", "Daytime Mucus Relief Severe Cold and Nighttime Cold and Flu Maximum Strength", "Cough and Cold HBP", "Cough and Cold HBP", "Multi-symptom Daytime", "Rynex DM", "Basic Care Nighttime Cold and Flu", "Multi-Symptom Mapap Cold Formula", "Sinus Pressure and Pain and Cough", "Childrens Robitussin Honey Nighttime Cough DM", "Alka-Seltzer Plus Severe Cold and Flu PowerFast Fizz", "Daytime and Nighttime Cold/Flu Relief", "Daytime and Nighttime Cold/Flu Relief", "Nighttime Cold/Flu Relief Softgels", "Daytime Cold/Flu Relief Softgels", "Alka-Seltzer Plus Severe Cold Powerfast Fizz Night", "Alka-Seltzer Plus Severe Cold PowerFast Fizz Non Drowsy", "Target Cough plus Chest Congestion DM Max with Honey", "Cough and Cold HBP", "TYLENOL Cold Max Day", "TYLENOL Cold Plus Flu Severe", "Tylenol Cold Plus Flu Severe Day/night", "Tylenol Cold Plus Flu Severe Day/night", "Basic Care Daytime Nighttime Cold and Flu", "Basic Care Daytime Nighttime Cold and Flu", "Tussin CF Non Drowsy", "Alka-Seltzer Plus Severe Cold PowerFast Fizz", "Alka-Seltzer Plus Severe Cold PowerFast Fizz", "Health Mart Night Time Cold and Flu", "Daytime Nightime Severe Cold", "Severe Cold Cough and Flu Relief Daytime", "Sunmark Nite Time", "Vicks Severe Cold and Flu", "Cold, Flu, and Sore Throat", "Daytime Cold and Flu Relief", "Vicks Severe Cold and Flu", "Cold and Flu Relief", "Walgreens DAY and NIGHT PACK", "Walgreens DAY and NIGHT PACK", "Fast Mucus Relief", "Vicks DayQuil NyQuil Severe Cold and Flu combo", "Vicks DayQuil NyQuil Severe Cold and Flu combo", "Brompheniramine Maleate, Pseudoephedrine Hydrochloride, and Dextromethorphan Hydrobromide", "Head and Cold", "Cold and Flu daytime", "Cold, Flu, and Sore Throat", "Tussin DM Max Nighttime", "Cough and Cold HBP", "Health Mart Night Time Cold and Flu", "Dimaphen DM", "Mucus Relief Cold Flu and Sore Throat Max Maximum Strength", "Multi-Symptom Cold Flu and Sore Throat Maximum Strength", "Cold, Flu and Sore Throat Relief Maximum Strength, Multi Symptom", "Fast Mucus Relief", "Cold and Flu Daytime Severe", "Meijer Mucus Relief DM Maximum Strength", "Health Mart Adult Tussin", "Childrens Cold and Cough", "Cold Relief Multi-Symptom", "Cold Relief Multi-Symptom", "Aquanaz PSE", "Cold and Flu Multi-Symptom Daytime/Nighttime Severe", "Cold and Flu Multi-Symptom Daytime/Nighttime Severe", "Nite time Severe Cold and Flu Maximum Strength", "Meijer Maximum Strength Severe Congestion and Cough", "Childrens Robitussin Cough and Chest Congestion DM", "Capron DM", "Brompheniramine Maleate, Pseudoephedrine Hydrochloride and DextromethorphanHydrobromide", "Guaifenesin and Dextromethorphan HBr", "Health Mart Adult Tussin", "Basic Care Daytime Nighttime Severe Cold and Flu", "Basic Care Daytime Nighttime Severe Cold and Flu", "Cold and Flu Daytime Severe", "Vicks NyQuil D Severe Cold And Flu", "Cold Childrens, Multi Symptom", "Flu HBP", "Severe Cold and Flu Daytime/nighttime", "Severe Cold and Flu Daytime/nighttime", "Nighttime Severe Cold and Flu", "Health Mart Adult Tussin", "Cold and Flu Nighttime", "Cough Be Gone", "Baczol Cold Medicine", "Daytime Liquid Caps", "Mucus Relief DM Maximum Strength", "Cold and Flu Severe Day Time / Night Time", "Cold and Flu Severe Day Time / Night Time", "Health Mart Cold and Cough childrens", "cold and flu relief hbp MAXIMUM STRENGTH multi-symptom", "Day Time Cold and Flu Relief non drowsy", "Adult Cough and Chest Congestion Relief DM Non Drowsy", "Cold, Flu and Sore Throat Maximum Strength, Multi-Symptom", "Cold Flu and Sore Throat Relief Maximum Strength", "Childrens Multi Symptom Fever and Cold", "Mucus Relief DM and Overnight Cold and Flu", "Mucus Relief DM and Overnight Cold and Flu", "Daytime Severe Cold and Flu", "Daytime-nighttime Severe Cold and Flu", "Daytime-nighttime Severe Cold and Flu", "Nighttime Severe Cold and Flu", "Cold and Flu Nighttime/multi-symptom", "Sunmark Day time cold and flu", "Mucinex Nightshift Severe Cold and Flu", "Alka-Seltzer Plus Maximum Strength Cough, Mucus and Congestion Powermax", "Alka-Seltzer Plus Maximum Strength Cough, Mucus and Congestion Day and Night", "Alka-Seltzer Plus Maximum Strength Cough, Mucus and Congestion Day and Night", "Mucinex Sinus-Max Pressure, Pain and Cough", "Cold and Flu Nighttime Severe", "DayTime Cold and Flu Non Drowsy", "Mucinex Fast-Max DM Max Honey and Berry Flavor", "Cough Be Gone", "Alka-Seltzer Plus Cough, Mucus and Congestion Day and Night Powermax", "Alka-Seltzer Plus Cough, Mucus and Congestion Day and Night Powermax", "Night Time Multi Symptom Flu Cold Medicine", "SanaTos Severe Cold and Cough Day Time", "Cold and Flu Daytime, Nighttime", "Cold and Flu Daytime, Nighttime", "Severe Cold and Flu Relief", "Target Maximum Strength Cold Flu and Sore Throat Overnight Cold and Flu", "Target Maximum Strength Cold Flu and Sore Throat Overnight Cold and Flu", "Target Maximum Strength Cold Flu and Sore Throat", "CVS Childrens Cold plus Cough plus Runny Nose", "Target Overnight Cold and Flu", "Mucus Relief Severe Congestion and Cough Multi Symptom Relief", "Maximum Strength Mucinex Fast-Max Cold and Flu", "Cold and Flu Daytime-nighttime", "Cold and Flu Daytime-nighttime", "Cold Flu Severe", "Cold Flu Severe", "Mucinex Childrens FreeFrom Multi-Symptom Cold and Stuffy Nose", "Mucinex Childrens FreeFrom Multi-Symptom Cold and Flu Nighttime", "Nighttime Cold and Flu Relief Multi Symptom", "ANTIGRIP Daytime", "Mucinex Childrens FreeFrom Multi-Symptom Cold, Flu and Sore Throat", "ANTIGRIP Nighttime", "Mucinex Childrens FreeFrom Cough and Mucus", "Mucinex FreeFrom Severe Congestion and Cough", "Mucinex FreeFrom Cold and Flu Nighttime", "Cetafen Cough and Cold", "Maximum Strength Cold and Flu", "Mucinex FreeFrom Cold and Flu Daytime", "Mucus Relief Cold, Flu and Sore Throat", "pressure and pain sinus relief PE NON-DROWSY", "Severe Congestion and Cough Relief Maximum Strength", "Leader Mixed Berry Benz-Dex Lozenges", "Tussin DM Max", "CVS Mucus Relief DM and Overnight Cold and Flu", "CVS Mucus Relief DM and Overnight Cold and Flu", "Green Guard Cough and Cold Relief", "Cold and Flu Relief Non-Drowsy / Daytime Severe / Nighttime Severe", "Cold and Flu Relief Non-Drowsy / Daytime Severe / Nighttime Severe", "Flu HBP", "Severe Cold and Flu Relief", "Mediqe Medi-Mucus", "Multi-Symptom Cold", "Cold, Flu and Sore Throat Maximum Strength", "Nighttime Cold and Flu Relief Alcohol Free", "Cold and Flu Severe", "Medique Decorel Forte Plus", "Medi-First Cold Relief", "Medi-First Plus Cold Relief", "Cold and Flu Daytime Relief", "CVS Overnight Cold and Flu Clear and Cool", "Severe Cough and Congestion and Cold and Flu Daytime, Nighttime", "severe cold, cold and flu Daytime/Nighttime", "Father Johns Cough Medicine Plus", "Crane Safety Cold Relief", "Brompheniramine Maleate, Pseudoephedrine Hydrochloride and Dextromethorphan Hydrobromide", "Mucus Relief, Cold, Flu and Sore Throat Maximum Strength, Multi-Symptom", "Moore Medical MooreBrand Severe Cold Relief", "Mucinex Fast-Max Day Time Severe Congestion and Cough - Mucinex Fast-Max Night Time Cold and Flu Maximum Strength", "CVS Nighttime Cold and Flu", "Cold and Flu Daytime", "Meijer Nighttime Cold and Flu", "Robitussin Sugar-Free Dye-Free Cough Plus Chest Congestion DM", "Mucus Relief DM", "Robitussin Honey Severe Cough, Flu Plus Sore Throat", "Severe Congestion and Cough Multi-Symptom Maximum Strength", "Rugby Cough", "Up and Up Cold and Flu Relief Multi Symptom Day and Night Combo Pack", "Up and Up Cold and Flu Relief Multi Symptom Day and Night Combo Pack", "Mucus Relief", "Daytime Cold Relief Multi Symptom", "Acetaminophen, Dextromethorphan Hydrobromide, Phenylephrine Hydrochloride", "Mixed Berry Sore Throat and Cough Lozenge", "DEXTROMETHORPHAN HYDROBROMIDE, GUAIFENESIN, and PHENYLEPHRINE HYDROCHLORIDE", "Night Time Cough Cherry", "Night Time Cold Multi-Symptom", "Cold DayTime, Multi-Symptom, Non-drowsy", "Daytime Flu and Severe", "Mucus DM Max", "Mucus DM Extended Release", "Mixed Berry Sore Throat Lozenge", "Severe Cold Head Congestion", "Smart Sense Cough and Chest Congestion", "Severe Cold and Flu", "CVS Health Non Drowsy Daytime Cold and Flu Relief And Nighttime Cold and Flu Relief Day and Night Twin Pack", "CVS Health Non Drowsy Daytime Cold and Flu Relief And Nighttime Cold and Flu Relief Day and Night Twin Pack", "Mucus Relief DM", "Adult Severe Congestion and Cough", "DayTime NiteTime Cold and Flu", "DayTime NiteTime Cold and Flu", "Healthy Accents Tussin DM cough and chest congestion", "Leader Nite Time Cough", "Leader Childrens Mucus Relief Cough", "Mixed Berry sore throat and cough lozenge", "Cold Multi-Symptom", "Cold Multi-Symptom", "Harmon Face Values Tussin DM Adult", "Daytime NiteTime", "Daytime NiteTime", "CVS Nighttime Cold/Flu Relief", "Gripmax", "Cold Head Congestion Daytime / Nighttime", "Cold Head Congestion Daytime / Nighttime", "Robitussin Peak Cold Maximum Strength Multi-symptom Cold", "healthy accents cold and cough DM", "Cold and Flu Severe", "Day Time Cold Head Congestion Severe", "Careone Allergy and Cough Severe Sinus Congestion", "Walgreen Nighttime Cold and Flu Relief", "McKesson Nite Time", "Leader Nite Time Cold Flu Relief Multi Symptom", "Leader Mucus DM", "Childrens mucus relief multi-symptom cold", "Robitussin To Go Cough and Cold CF", "Members Mark mucus relief DM", "Night Relief Free", "Sanatos", "CareOne Adult Tussin CF", "Giltuss Pediatric", "Alka-Seltzer Plus Day Cold and Flu", "Childrens Plus Multi-Symptom Cold Grape with PE", "Equate Daytime Nitetime", "Equate Daytime Nitetime", "XL-3 Xtra", "Good Sense Cough and Sore Throat Night Time", "Cold and Cough Nighttime", "G-P-tuss Dxp", "Smart Sense Mucus Relief Cough Childrens", "Cold", "Cold", "Wal Tussin Cough and Chest Congestion", "Smart Sense Daytime", "Acetaminophen, Dextromethorphan Hydrobromide, Guaifenesin, Phenylephrine Hydrochloride", "Berkley Jensen Tussin", "Biobron SF", "Daytime Nighttime Severe Cough and Cold", "Equaline Mucus DM", "CareOne Nitetime Cold Flu Relief", "Guaifenesin and Dextromethorphan Hydrobromide", "Mucinex DM", "Cold and Flu", "Tylenol Cold Max Day", "Day and Night Cold", "CareOne Mucus Relief DM", "Despec-DM Tabs", "Daytime PE Nitetime", "Daytime PE Nitetime", "Leader Tussin", "Day Relief Night Relief Free", "Day Relief Night Relief Free", "Guaifenesin DM", "All-Nite Cold and Flu", "Allfen DM", "CVS Daytime Severe Cough and Cold", "Preferred Plus Severe Cold", "Cold and Flu Severe", "Cold Relief Multi-symptom", "Cold Relief Multi-symptom", "Cold Pain Relief", "Mucus Relief Cold Flu and Sore Throat", "Severe Cold and Flu", "Severe Cold and Flu", "CVS Health Non-Drowsy Daytime Cold and Flu Relief Single Serve Cups Daytime", "Wal Tussin DM Max Cough and Chest Congestion", "Diabetic Siltussin DM DAS-Na", "ShopRite Adult Tussin", "Equate Flu and Severe Cold and Cough", "Good Sense Severe Sinus Congestion", "Mucinex Fast-Max Severe Congestion and Cough", "DayClear COUGH COLD AND FLU", "Preferred Plus Severe Day Time", "Wal Tussin Adult Cough and Cold", "Entre-Cough", "Zyncof", "Harris Teeter Mucus Relief DM", "TopCare Mucus Relief and Cold and Flu", "Deconex DMX", "Coricidin Max Flu", "Pediatric Cough and Cold Medicine", "Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hydrobromide, Phenylephrine Hydrochloride", "Maxiphen DM", "Daytime Mucus Relief Nighttime Cold and Flu", "Tussi Pres", "Mucus DM", "Cold Head Congestion Night Time", "Leader Tussin CF Max", "Mucinex DM Maximum Strength", "Mixed Berry Sore Throat and Cough Lozenge", "Cold Head Congestion Nighttime", "Desgen DM", "Leader TabTussin DM TDM", "Triaminic cough and sore throat", "Healthy Accents Mucus Relief DM", "Triaminic Cough and Congestion", "Cold and Flu", "Cold and Flu", "CareOne Daytime Cold Flu Relief", "Sore Throat and Cough", "Preferred Plus Childrens Mucus Relief Multi Symptom Cold", "CVS Health Nighttime Cold and Flu Relief Single Serve Cups Cold and Flu Nighttime Relief", "Night Time Cold and Flu", "Severe Cold", "Severe Cold and Flu Night time", "NightTime", "Leader Flu and Severe Cold and Cough", "Pressure Pain Cough PE", "Daytime Severe Cold and Flu Relief Maximum Strength", "Multi Symptom Fever and Cold Childrens", "Leader Nite Time Severe Cold and Flu", "Assured Childrens Cold and Cough", "Daytime Nighttime Severe Cold and Flu", "Daytime Nighttime Severe Cold and Flu", "Leader Day Time Multi Symptom Cold Flu Relief", "Good Sense cold multi symptom", "Giltuss", "Assured Day time Cold and Cough", "Leader Severe Sinus Congestion", "M-Hist DM", "Robitussin To Go Cough and Chest Congestion DM", "Healthy Accents Tussin DM", "Robitussin Peak Cold Nighttime Cold Plus Flu", "Cold Head Congestion Nighttime", "Daytime Nighttime Cold and Flu Relief", "Daytime Nighttime Cold and Flu Relief", "CareOne Adult Tussin DM sugar free", "Cold and Flu", "Acetaminophen, Dextromethorphan Hydrobromide, Guaifenesin, Phenylephrine Hydrochloride", "Tussin DM", "mucus relief DM", "Acetaminophen, Dextromethorphan Hydrobromide, Guaifenesin, Phenylephrine Hydrochloride", "Publix Cherry Flavor Nitetime", "Cold Multi-Symptom", "Up and Up Nighttime Daytime Cold and Flu", "Up and Up Nighttime Daytime Cold and Flu", "Entre-S", "Robitussin Peak Cold Maximum Strength Cough Plus Chest Congestion DM", "BroveX PEB DM", "Guaifenesin DM", "Harmon Face Values Night Time Relief", "Day Time", "ShopRite Day Calm", "Rabofen DM", "Signature Care Mucus Relief DM", "Severe Cold and Flu", "Promethazine DM", "Smart Sense Cough and chest congestion", "Daytime Cold and Flu relief", "Preferred Plus Intense Cough Reliever", "Day Time Night Time", "Day Time Night Time", "Leader Nite Time", "Good Neighbor Pharmacy Mucus DM", "Target Cold/Flu Relief", "Daytime Nitetime Cold and Flu", "Daytime Nitetime Cold and Flu", "Cold and Cough", "Up and Up Mucus Relief DM", "Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hydrobromide, Phenylephrine Hydrochloride", "Daytime Nitetime Cold and Flu", "Daytime Nitetime Cold and Flu", "AP-Hist DM", "Tussin DM", "Brompheniramine Maleate, Pseudoephedrine Hydrochloride and Dextromethorphan Hydrobromide", "Cold and Flu", "Lortuss DM", "Pedia Relief", "Careone Daytime Severe Cold Flu Relief", "Promethazine DM", "DG Health Mucus DM", "Delsym and Childrens Delsym", "Delsym and Childrens Delsym", "Tussin CF Adult Cough and Cold", "Severe Cold and Flu", "Mucus Relief DM", "Cold Multi-Symptom Nighttime", "Robitussin Maximum Strength Nighttime Cough DM", "Nighttime Cold and Flu", "CareOne Adult Tussin DM", "Tussin Multi Symptom", "Leader Childrens Cold and Cough", "Capmist DM", "Leader Day Time", "Daytime Nite Time", "Daytime Nite Time", "BroveX PSB DM", "Berkley and Jensen Tussin Cough and Chest Congestion DM", "Cough and Cold XL3 Xtra", "Dr Manzanilla DM", "Severe Sinus Congestion", "good sense DayTime Night Time", "good sense DayTime Night Time", "Severe Cold and Flu Nighttime Daytime", "Severe Cold and Flu Nighttime Daytime", "Leader Day Time", "G Tron", "Cough Relief Daytime Nighttime", "Cough Relief Daytime Nighttime", "Sore Throat and Cough Lozenge", "Harmon Face Values Night Time Relief", "Harmon Face Values Tussin CF", "Non Drowsy Cold and Cough PE", "CareOne Nitetime Cold Flu Relief", "Duravent DM", "Head Congestion Daytime and Nighttime Cold", "Head Congestion Daytime and Nighttime Cold", "Equate Mucus DM", "Equate Daytime Nitetime", "Equate Daytime Nitetime", "Healthy Accents Day Time Night Time", "Healthy Accents Day Time Night Time", "Healthy Accents Night Time Cough", "Mucus Relief DM", "CareOne Day Time Severe Cold Night Time Cold and Flu", "Mucus Relief DM Max", "CareOne Daytime Nighttime Cold Flu Relief", "CareOne Daytime Nighttime Cold Flu Relief", "Good Sense Adult Tussin DM", "Cold and Flu Day Night", "Cold and Flu Day Night", "Triaminic Day - Night Club Pack", "Childrens Mucus Relief", "Alka-Seltzer Plus Severe Cold and Cough Night", "Maximum Strength Mucus Relief Severe Congestion and Cough", "Healthy Accents Daytime", "Adult Cold, Flu and Sore Throat", "TopCare Mucus DM", "COMTREX Maximum Strength Cold and Cough Non-Drowsy", "Acetaminophen, Dextromethorphan Hydrobromide, Phenylephrine Hydrochloride", "Severe Nighttime Cold and Flu", "NorelCS CS", "Guaifenesin Phenylephrine Dextromethorphan", "CareOne Cold and Cough", "Good Sense Tussin CF Cough and Cold", "Wal Tussin", "Mucus DM Max", "DAYTIME SEVERE COLD and COUGH NIGHTTIME SEVERE COLD and COUGH", "NyQuil Severe Cold and Flu", "Pecgen DMX", "Cold and Flu", "Care One Cold Mutli Symptom", "Alka-Seltzer Plus Night Cold Formula (Lemon)", "Dg Health Flu and Severe Cold and Cough", "Duraflu", "Mucinex Childrens Cough and Congestion", "Cold and Flu Daytime/Nightime", "Cold and Flu Daytime/Nightime", "Flu HBP Maximum Strength", "Mucus Relief DM Maximum Strength", "Maximum Strength Mucus Relief DM", "Equate Daytime Cold and Flu Nighttime Cold and Flu", "Equate Daytime Cold and Flu Nighttime Cold and Flu", "Mucus Relief DM", "Maximum Strength Mucinex Fast-Max Day Time Cold and Flu and Night Time Cold and Flu", "Cold and Flu Daytime", "Cold and Flu Daytime", "Cold and Flu Daytime", "Cold and Flu Daytime", "Cold and Flu Daytime", "Giltuss Honey Cough and Chest Congestion", "Cold and Flu Daytime, Nighttime, Multi-Symptom", "Cold and Flu Daytime, Nighttime, Multi-Symptom", "Mucinex Childrens FreeFrom Multi-Symptom Cold, Flu and Sore Throat and Mucinex Childrens FreeFrom Multi-Symptom Cold and Flu Nighttime", "Mucinex Childrens FreeFrom Multi-Symptom Cold, Flu and Sore Throat and Mucinex Childrens FreeFrom Multi-Symptom Cold and Flu Nighttime", "Childrens Giltuss Honey Cough and Chest Congestion", "Defensol Adult Syrup", "Robitussin CF", "Dr Cocoa Day Night Combo", "Breacold Adult", "Circle K Daytime Cold and Flu", "Day Time Night Time Cold and Flu", "Day Time Night Time Cold and Flu", "Mucinex FreeFrom Cold and Flu Daytime and Mucinex FreeFrom Cold and Flu Nighttime", "Mucinex FreeFrom Cold and Flu Daytime and Mucinex FreeFrom Cold and Flu Nighttime", "Brompheniramine maleate, pseudoephedrine hydrochloride,", "Brompheniramine maleate, pseudoephedrine hydrochloride,", "Delsym Nighttime Cough", "Kids Cough and Chest Congestion", "Coricidin HBP Maximum Strength Cold, Cough and Flu", "Coricidin HBP Maximum Strength Cold and Flu Day and Night", "Coricidin HBP Maximum Strength Cold and Flu Day and Night", "Multi-symptom Daytime", "Mucus Relief DM", "Severe Nighttime Cold and Flu", "Multi-symptom Nitetime", "COLD and FLU DAYTIME MAXIMUM STRENGTH NON-DROWSY SEVERE", "Maximum Strength Daytime - Nighttime Cold and Flu Cold and Flu", "Maximum Strength Daytime - Nighttime Cold and Flu Cold and Flu", "Daytime Cold and Flu Multi Symptom", "Nightime Cold and Flu", "Tukol Cough and Congestion", "Robafen", "Daytime- Nighttime Cold and Flu", "Daytime- Nighttime Cold and Flu", "Maximum Strength Nighttime Cold and Flu", "Dg Health Day Time Severe Cold and Flu", "Signature Care Daytime Severe Cold and Flu Relief", "Mucus Relief DM Maximum Strength", "Brompheniramine, Pseudoephedrine, Dextromethorphan", "Dg Health Night Time Severe Cold and Flu Relief", "Flu HBP Maximum Strength", "Signature Care Nighttime Severe Cold and Flu Relief", "Daytime Cold and Flu Non Drowsy", "Daytime Nighttime Cold Flu Relief", "Daytime Nighttime Cold Flu Relief", "Maximum Strength Cough Plus Chest Congestion DM", "Mucinex Childrens FreeFrom Multi-Symptom Cold, Flu and Sore Throat and Mucinex Childrens FreeFrom Multi-Symptom Cold and Flu Nighttime", "Mucinex Childrens FreeFrom Multi-Symptom Cold, Flu and Sore Throat and Mucinex Childrens FreeFrom Multi-Symptom Cold and Flu Nighttime", "Equate Vapor Ice Cold and Flu", "Maxi-Tuss G", "Maxi-Tuss Jr", "Maxi-Tuss GMX", "Equate Vapor Ice Cold and Flu", "Night Time Cold and Flu Relief Multi Symptom", "Guaifenesin and Dextromethorphan HBr", "Severe Vapor Ice Cold and Flu Relief", "Night Time Cold and Flu Relief Multi Symptom", "Daytime Liquid Caps", "Daytime", "Equate Daytime Nighttime Cold and Flu", "Equate Daytime Nighttime Cold and Flu", "Mucus Relief DM Maximum Strength", "Bisolvine Adult", "Cough and Chest Congestion DM Adult", "Equate daytime severe vaporice cold and flu nighttime severe vapor ice cold and flu", "Equate daytime severe vaporice cold and flu nighttime severe vapor ice cold and flu", "Day-night Severe Cold and Flu", "Day-night Severe Cold and Flu", "Mucinex Sinus-Max Pressure, Pain and Cough and Mucinex Sinus-Max Severe Congestion Relief Clear and Cool", "Fast Dissolving Daytime - Nighttime Cold and Flu", "Fast Dissolving Daytime - Nighttime Cold and Flu", "Day Maximum Strength Cold and Flu Relief", "Day Maximum Strength Cold and Flu Relief", "Cold and Flu Night", "Cold", "Cold Night", "Maximum Strenth Night Cold and Flu Formula", "Maximum Strenght Day Cold and Flu Formula", "Maximum Strength Cold and Flu", "Maximum Strength Day-night Cold and Flu Formula", "Maximum Strength Day-night Cold and Flu Formula", "Equate Childrens Multi Symptom Cold", "Rugby Chest Congestion Relief DM", "Leader Chest Congestion Relief DM", "Tukol Honey Children Cough and Congestion", "Tukol Honey Nighttime Cold and Flu", "Tukol Honey Daytime Cold and Flu", "Childrens Multi Symptom Fever and Cold", "Acetaflu Cough and Chest Congestion", "Miclara DM", "ASP Nighttime Max", "ASP Daytime PE", "Coricidin HBP Maximum Strength Multi Symptom Flu", "Maximum Strength Cold Flu and Sore Throat", "Kroger Maximum Strength Severe Congestion and Cough", "SEVERE COLD DAY COLD and FLU NIGHT", "Cold Flu and Sore Throat", "Mucus Relief Sinus Pressure Pain and Cough", "Daytime Nighttime Cold and Flu", "COLD and FLU SEVERE", "Pressure and Pain and Cold", "Cold Max Multi Symptom Nighttime", "Mucus Relief Severe Cold", "Cold Max", "Mucus Relief Cold and Flu All In One", "Cold Max Multi Symptom", "Cold Max Multi Symptom Severe", "Cold Max", "Cold and Flu Severe", "Mucus Relief Cold, Flu and Sore Throat", "Cold and Flu All In One", "Cold and Flu Severe", "Cold and Flu Severe Daytime", "Cold and Flu Severe", "Cold and Flu Severe", "JEGAMSAN Extract", "SoCheongRyong Tang Extract", "Cold and Flu Daytime, Nighttime, Multi-Symptom", "Cold and Flu Daytime, Nighttime, Multi-Symptom", "NightTime Cold and Flu", "Daytime Non-Drowsy Cold and Flu", "Cold and Flu Daytime, Nighttime, Multi-Symptom", "Cold and Flu Daytime, Nighttime, Multi-Symptom", "Tukol Honey Daytime and Nighttime Value Pack", "Tukol Honey Daytime and Nighttime Value Pack", "Severe Cold and Cough Relief Daytime", "Novalgina Children Cough and Cold", "Cold and Flu Severe", "Cold and Flu Relief Daytime/Nighttime", "Cold and Flu Relief Daytime/Nighttime", "Mucus Relief DM", "Cold and Flu Relief Daytime", "Promethazine Hydrochloride and Dextromethorphan Hydrobromide Oral Solution", "Tussin CF", "Nighttime Cold and Flu Relief Multi Symptom", "Kroger Nighttime Cold and Flu Relief", "Berkley and Jensen Mucus Relief DM", "Good Sense Mucus Relief Cold Flu and Sore Throat", "Brompheniramine Maleate, Pseudoephedrine Hydrochloride, and Dextromethorphan Hydrobromide", "Maximum Strength Severe Congestion and Cough", "Chest Congestion Relief DM", "Basic Care Daytime", "Daytime Nighttime Cold and Flu", "Daytime Nighttime Cold and Flu", "Guaifenesin Syrup and Dextromethorphan", "Guaifenesin Syrup and Dextromethorphan", "Tussin Cough Expectorant Cough Supressant DM", "Cold, Flu and Sore Throat Multi-Symptom", "Severe Cold and Flu Relief Daytime", "Alka-Seltzer Plus Maximum Strength Day and Night Cold and Flu", "Alka-Seltzer Plus Maximum Strength Day and Night Cold and Flu", "Cold and Flu Relief", "Cold and Flu Nighttime", "Daytime Nighttime Cold and Cough", "Daytime Nighttime Cold and Cough", "Mucus Relief Cold Flu Sore Throat Maximum Strength", "Mucus Relief DM", "Coricidin HBP Cough and Cold", "Mucus Relief DM", "Guaifenesin and Dextromethorphan Hydrobromide", "Nighttime Cold and Flu Relief", "Daytime Nighttime Cold and Flu", "Daytime Nighttime Cold and Flu", "Daytime Cold and Flu", "Night Time Cold and Flu", "Cold and Flu Relief Multi-Symptom, DayTime", "Daytime Cold and Flu", "Cold and Flu Relief Multi symptom, Nighttime", "Cold and Flu Nighttime/Multi-Symptom", "Cold and Flu", "Maximum Strength Non Drowsy Day and Night Cold and Flu", "Maximum Strength Non Drowsy Day and Night Cold and Flu", "Severe Cough and Congestion", "Wal-Tussin DM", "Mucus Relief cold and flu Daytime/Nighttime", "Cold and Flu Daytime, Nighttime", "Cold and Flu Daytime, Nighttime", "Mucus Relief Cold and Flu All in One", "Mucus Relief Sinus Pressure Pain and Cough", "Mucus Relief Cold and Flu all in one", "Mucus Relief Cold Flu and Sore Throat", "Mucus Relief Cold and Flu", "Mucus Relief Cold Flu and Sore Throat", "Nighttime HBP Cold and Flu Relief", "Night Time Severe Cold and Flu", "SanaTos Boost", "Mucus Relief Cold, Flu and Sore Throat", "Sanatos Lozenges EX", "Cold and Cough Relief children", "Cold and Flu Relief Daytime, Nighttime", "Cold and Flu Relief Daytime, Nighttime", "ACETAMINOPHEN, DEXTROMETHORPHAN HBr, GUAILFENESIN,PHENLYEPHRINE HCL", "Vapor Chill Cold and Flu Daytime/nighttime", "Vapor Chill Cold and Flu Daytime/nighttime", "Cough Syrup DM", "Basic Care Tussin DM Max", "Basic Care Daytime Severe Cold and Flu", "Maximum Strength Chest Congestion and Cough", "Basic Care Nighttime Cold and Flu", "Basic Care Nighttime Cold and Flu", "Cold and Flu Relief Daytime/Nighttime", "Cold and Flu Relief Daytime/Nighttime", "Basic Care Daytime Cold and Flu", "Basic Care Nighttime Severe Cold and Flu", "Medique at Home Cold Relief", "Basic Care Childrens Cold and Cough", "Brompheniramine Maleate, Pseudoephedrine Hydrochloride, and Dextromethorphan Hydrobromide", "Kroger Nighttime Cold and Flu Relief", "SanaTos Multi Symptom", "Green Tussin Pediatric", "Mucus Relief DM Honey and Berry Flavor", "NightTime Cold", "Daytime Cold and Flu Relief", "Brompheniramine Maleate, Pseudoephedrine Hydrochloride, and Dextromethorphan Hydrobromide", "Brompheniramine Maleate, Pseudoephedrine Hydrochloride, and Dextromethorphan Hydrobromide", "Brompheniramine Maleate, Pseudoephedrine Hydrochloride, and Dextromethorphan Hydrobromide", "Brompheniramine Maleate, Pseudoephedrine Hydrochloride, and Dextromethorphan Hydrobromide", "Basic Care Daytime Severe Cold and Flu Nighttime Severe Cold and Flu", "Basic Care Daytime Severe Cold and Flu Nighttime Severe Cold and Flu", "Good Sense Severe Daytime Cold and Flu Severe Nighttime Cold and Flu", "Good Sense Severe Daytime Cold and Flu Severe Nighttime Cold and Flu", "Walgreen Day Time NightTime Cold and Flu Relief", "Walgreen Day Time NightTime Cold and Flu Relief", "Vicks Formula 44 Cough and Sore Throat Lozenge", "Walgreen DayTime Cold and Flu Relief", "Mucus Relief Cold Flu and Sore Throat", "Walgreen Nighttime Cold and Flu", "CVS Maximum Strength Cold and Flu Relief", "Guaifenesin and Dextromethorphan HBr", "Multi-symptom Daytime", "Acetaminophen, Dextromethorphan Hydrobromide, Phenylephrine Hydrochloride", "Unishield Cold Relief", "Acetaminophen, Guaifenesin, Dextromethorphan HBr, Phenylephrine HCl", "Acetaminophen, Dextromethorphan Hydrobromide, Doxylamine Succinate", "Acetaminophen, Dextromethorphan HBr, Phenylephrine HCl, Doxylamine Succinate", "Walgreen Day Time Nighttime Cold and Flu Relief Honey Flavor", "Walgreen Day Time Nighttime Cold and Flu Relief Honey Flavor", "Mucus Relief Cold Flu and Sore Throat", "Mucus Relief Sinus Pressure Pain and Cough", "Mucus Relief Cold and Flu All in One", "Mucus Relief Cold Flu and Sore Throat", "Mucus Relief Cold and Flu All in One", "Kroger Chest Congestion Relief DM", "Basic Care Tussin CF Severe", "Reeses TABtussin DM", "Cold and Flu Nighttime Relief", "Severe Congestion and Cough Relief", "Xpect Cough Relief", "Basic Care Daytime Severe Cold and Flu Nighttime Severe Cold and Flu", "Basic Care Daytime Severe Cold and Flu Nighttime Severe Cold and Flu", "Cold and Flu DayTime Relief", "L-Oral COLD AND FLU RELIEF-DS Syrup", "Refenesen Mucus Relief DM", "Daytime Nighttime Cold and Flu Relief Multi-Symptom", "Daytime Nighttime Cold and Flu Relief Multi-Symptom", "Sinus Pressure Pain and Cough", "Mucus Relief Cough Childrens", "Daytime Nighttime Severe Cold and Flu Relief", "Daytime Nighttime Severe Cold and Flu Relief", "Equate Benz-Dex Cough and Throat Lozenges", "Pain Relief Plus Multi Symptom Cold Childrens", "Severe Cold and Flu Relief Daytime", "Severe cold and flu Nighttime", "Severe Cold and Cough Relief Daytime", "Cough and Chest Congestion DM", "Mucus Relief Cold, Flu and Sore Throat", "Head Congestion plus Flu Severe PE", "Mucus Relief Cold and Flu", "Multi-symptom Nitetime", "L-Oral COLD AND FLU RELIEF Syrup", "Multi-symptom Daytime", "Daytime Nighttime Cold and Flu Relief Multi-Symptom", "Daytime Nighttime Cold and Flu Relief Multi-Symptom", "L-Oral COUGH RELIEF Syrup", "Multi-symptom Daytime", "Mucus Relief DM", "Mucus Relief DM", "Cold and Flu Severe Daytime/Nighttime", "Cold and Flu Severe Daytime/Nighttime", "Cold and Flu Severe Nighttime", "Cold and Flu Severe Daytime", "Sinus Max Relief Day and Night", "Sinus Max Relief Day and Night", "Non Drowsy Daytime Cold and Flu Softgel", "Cold and Flu Daytime/Nighttime", "Cold and Flu Daytime/Nighttime", "Non Drowsy Nighttime Cold and Flu Softgel", "Toa Syrup Adult", "Head Congestion and Flu Severe Relief", "Mucus Relief DM", "TopCare Tab Tussin DM", "Cold and Flu Relief", "Cold and Flu Relief", "Daytime Cold and Flu", "Nighttime Cold and Flu", "Cold Multi-Symptom", "Cold and Flu Daytime", "Night Time Cold and Flu Multi Symptom", "Mucus Relief Xpect", "Mucus Relief Xpect", "Mucus Relief Xpect", "Theraflu Multi-symptom Severe Cold", "Head Congestion and Flu Severe", "Aspire Day Congestion and Headache Softgel", "Aspire Night Cold and Flu Softgel", "Aspire Daytime Mucus and Sinus Softgel", "Maximum Strength Daytime Nighttime Cold and Flu", "Maximum Strength Daytime Nighttime Cold and Flu", "Theraflu Multi-Symptom Severe Cold and Theraflu Nighttime Severe Cold and Cough", "Theraflu Multi-Symptom Severe Cold and Theraflu Nighttime Severe Cold and Cough", "Maximum Strength Daytime Nighttime Sinus Relief", "Maximum Strength Daytime Nighttime Sinus Relief", "Coricidin HBP Cough and Cold", "Aramark Multi-Symptom Cold Relief", "Nighttime Cold and Flu", "Daytime Cold and Flu Non drowsy", "Multi-Symptom Cold and Fever Childrens", "Vicks Formula 44 Cough and Congestion Severe Daytime and Nighttime", "Vicks Formula 44 Cough and Congestion Severe Daytime and Nighttime", "Vicks DayQuil Cough DM plus Congestion", "Night Time Cold and Flu original", "Tussin Cough and Chest Congestion DM adult", "Vicks Formula 44 VapoCool Sever Cough and Congestion", "Robitussin Elderberry Maximum Strength Cough plus Chest Congestion DM", "Childrens Robitussin Elderberry Cough and Chest Congestion DM", "Alka-Seltzer Plus Maximum Strength Sinus Congestion and Pain PowerFast Fizz", "Childrens Mucus Relief Cough, Cold and Sore Throat", "Childrens Cough and Cold CF", "Basic Care Daytime Severe Cold and Flu Nighttime Severe Cold and Flu", "Basic Care Daytime Severe Cold and Flu Nighttime Severe Cold and Flu", "Daytime Nighttime Cold and Flu", "Daytime Nighttime Cold and Flu", "Daytime Nighttime Cold Flu Relief", "Daytime Nighttime Cold Flu Relief", "Extra Strength TYLENOL Cold Plus Flu Multi-Action Day", "Extra Strength TYLENOL Cold plus Flu Multi-Action Day/Night", "Extra Strength TYLENOL Cold plus Flu Multi-Action Day/Night", "Mucus Relief DM", "Mucus Relief DM Maximum Strength", "Dg Health Day Time Severe Cold and Flu Relief Night Time Severe Cold and Flu Relief", "Dg Health Day Time Severe Cold and Flu Relief Night Time Severe Cold and Flu Relief", "Mucus Relief Severe Congestion and Cough Maximum Strength", "Cough and Cold HBP", "Nighttime Cold and Flu Relief", "CVS Health Daytime Severe Cold and Flu Relief", "CVS Daytime and Nighttime Severe Cold and Flu Relief Bundle", "CVS Daytime and Nighttime Severe Cold and Flu Relief Bundle", "Mucus Relief DM Max Maximum Strength", "CVS Nighttime Severe Cold and Flu Relief", "Cold and Flu Hbp", "Cold and Flu Daytime/Nightime", "Cold and Flu Daytime/Nightime", "Non-Drowsy Daytime Severe Cold Multi-Symptom", "Mucinex Nightshift Sinus Maximum Strength", "Mucinex Nightshift Severe Cold and Flu Maximum Strength", "Mucinex Fast-Max Severe Congestion and Cough Arctic Burst Maximum Strength", "Mucinex Instasoothe Sore Throat Plus Cough Relief", "Day Cold and Flu Relief", "Night Cold and Flu Relief", "Day-night Cold and Flu", "Day-night Cold and Flu", "Cold and Flu Severe, Daytime, Nighttime", "Cold and Flu Severe, Daytime, Nighttime", "Mucinex Fast-Max Day Severe Congestion and Cough and Mucinex Nightshift Night Cold and Flu Maximum Strength", "Mucinex Fast-Max Day Severe Congestion and Cough and Mucinex Nightshift Night Cold and Flu Maximum Strength", "Mucinex Sinus-Max Day Pressure, Pain and Cough and Mucinex Nightshift Night Sinus Maximum Strength", "Mucinex Sinus-Max Day Pressure, Pain and Cough and Mucinex Nightshift Night Sinus Maximum Strength", "Mucinex Nightshift Cold and Flu Maximum Strength", "Mucinex Fast-Max Day Cold and Flu and Mucinex Nightshift Night Severe Cold and Flu Maximum Strength", "Mucinex Fast-Max Day Cold and Flu and Mucinex Nightshift Night Severe Cold and Flu Maximum Strength", "Mucinex Fast-Max Cold and Flu Arctic Burst Maximum Strength", "Mucinex Nightshift Severe Cold and Flu Arctic Burst", "Guaifenesin and Dextromethorphan HBr", "Guaifenesin and Dextromethorphan HBr", "Daytime Nighttime Cold and Flu", "Daytime Nighttime Cold and Flu", "Vicks DayQuil Kids Cold Cough plus Mucus", "Pulmo Calcio", "Brompheniramine Maleate, Pseudoephedrine Hydrochloride and Dextromethorphan Hydrobromide", "Brompheniramine Maleate, Pseudoephedrine Hydrochloride and Dextromethorphan Hydrobromide", "Vicks NyQuil Kids Honey Cold Cough Congestion", "Alka-Seltzer Plus Severe Cold Night PowerFast Fizz", "Maximum Strength Cold, Flu and Sore Throat", "Maximum Strength Cold and Flu", "Equate Mucus Relief DM", "Basic Care Daytime Nighttime Cold and Flu", "Basic Care Daytime Nighttime Cold and Flu", "Tussin", "Nighttime Cough DM", "Cold and Flu Severe, Day, Night", "Cold and Flu Severe, Day, Night", "DoloMax Cold Cough", "Sound Body Daytime Cold and Flu Relief Nighttime Cold and Flu Relief", "Sound Body Daytime Cold and Flu Relief Nighttime Cold and Flu Relief", "Brompheniramine Maleate, Pseudoephedrine Hydrochloride, Dextromethorphan Hydrobromide", "Basic Care Childrens Mucus Relief", "Signature Care Childrens Multi Symptom Cold", "Basic Care Mucus DM", "Mucinex Sinus-Max Severe Congestion and Pain Maximum Strength", "Mucinex Fast-Max Cold, Flu and Sore Throat Maximum Strength", "Mucinex Fast-Max Congestion and Headache Maximum Strength", "Mucinex Fast-Max Cold and Flu Maximum Strength", "Mucinex Sinus-Max Pressure, Pain and Cough Maximum Strength", "Caring Mill Adult Tussin", "Mucus Relief DM", "WesTussin DM", "Basic Care Daytime Severe Cold and Flu", "Daytime Nighttime Cold Flu Relief", "Daytime Nighttime Cold Flu Relief", "Daytime Cold and Flu", "Basic Care Nighttime Cold and Flu", "Nighttime Cold and Flu Relief", "Up and Up Daytime Multi Symptom Severe Cold Nighttime Severe Cold and Cough", "Alka-Seltzer Plus Severe Cold PowerFast Fizz Day and Night", "Alka-Seltzer Plus Severe Cold PowerFast Fizz Day and Night", "DrKids Childrens Cough and Chest Congestion DM", "Basic Care Daytime Severe Cold and Flu Nighttime Cold and Flu", "Basic Care Daytime Severe Cold and Flu Nighttime Cold and Flu", "Care One Chest Congestion Relief DM", "Guaifenesin and Dextromethorphan HBr", "Basic Care Tussin DM", "Basic Care Severe Cold and Flu", "Basic Care Childrens Mucus Relief", "Exactuss Total Release", "Mucus Relief Cough and Congestion DM", "Guaifenesin and Dextromethorphan HBr", "COLD, Flu and Sore Throat", "Maximum Strength Cold and Flu", "Daytime and Nighttime Sinus Relief", "Daytime and Nighttime Sinus Relief", "Maximum Strength Congestion and Headache", "Severe Congestion Relief", "Daytime and Nighttime Cold and Flu", "Daytime and Nighttime Cold and Flu", "Mucus Relief DM", "DAYTIME and NIGHTTIME SEVERE COLD AND FLU DAYTIME NON DROWSY NIGHTTIME", "DAYTIME and NIGHTTIME SEVERE COLD AND FLU DAYTIME NON DROWSY NIGHTTIME", "Daytime Severe Cold and Flu Relief", "Non Drowsy DAYTIME and NIGHTTIME Sinus Congestion and Cough Relief", "Non Drowsy DAYTIME and NIGHTTIME Sinus Congestion and Cough Relief", "Severe Nighttime Cold and Flu", "Walgreens NightTime Cold and Flu", "Cold and Flu Daytime, Nighttime, Multi-Symptom", "Cold and Flu Daytime, Nighttime, Multi-Symptom", "SEVERE DAYTIME COLD and FLU DAYTIME MAXIMUM STRENGTH NON-DROWSY SEVERE", "Daytime Non-Drowsy Cold and Flu", "Severe Nighttime Cold and Flu", "SEVERE COLD AND FLU DAYTIME NON DROWSY and NIGHTTIME", "SEVERE COLD AND FLU DAYTIME NON DROWSY and NIGHTTIME", "Cold and Flu Daytime, Nighttime, Multi-Symptom", "Cold and Flu Daytime, Nighttime, Multi-Symptom", "SEVERE COLD AND FLU DAYTIME NON DROWSY and NIGHTTIME", "SEVERE COLD AND FLU DAYTIME NON DROWSY and NIGHTTIME", "DayTime NightTime Cold and Flu Relief", "DayTime NightTime Cold and Flu Relief", "Mucus Relief All in One Maximum Strength", "Brompheniramine Maleate, Pseudoephedrine Hydrochloride and Dextromethorphan Hydrobromide", "Dimetapp Cold and Cough", "Multi-symptom Cold and Flu Relief Daytime Nighttime", "Multi-symptom Cold and Flu Relief Daytime Nighttime", "Dimetapp Cold and Cough and Nighttime Cold and Congestion", "Vicks NyQuil Cough DM plus Congestion", "Multi-symptom Cold and Flu Relief Daytime", "Dimetapp Cold and Cough and Dimetapp Nighttime Cold and Congestion", "Multi-symptom Cold and Flu Relief Nighttime", "Basic Care Daytime Cold and Flu", "Severe DayTime NightTime Cold and Flu Relief Max Strength", "Severe DayTime NightTime Cold and Flu Relief Max Strength", "Cold and Flu maximum strength", "Mucus Relief Severe Congestion and Cough Maximum Strength", "MMM - Cough Formula Guaifenesin DM", "Basic Care Daytime Cold and Flu Nighttime Cold and Flu", "Basic Care Daytime Cold and Flu Nighttime Cold and Flu", "Caring Mill Nighttime", "Basic Care Nighttime Severe Cold and Flu", "Caring Mill Childrens Cold and Cough", "Daytime Cold and Flu Nighttime Cold and Flu", "Daytime Cold and Flu Nighttime Cold and Flu", "Chest Congestion Relief DM", "Chest Congestion Relief DM", "Promethazine Hydrochloride and Dextromethorphan Hydrobromide Oral Solution", "Dometuss-G", "Basic Care Mucus DM", "Caring Mill Childrens Mucus Relief", "Tylenol Cold Plus Flu Severe", "Daytime Nighttime Cold and Flu", "Daytime Nighttime Cold and Flu", "Tylenol Cold Plus Flu Severe Day and Tylenol Cold Plus Flu Plus Cough Night 2-pack", "Tylenol Cold Plus Flu Severe Day and Tylenol Cold Plus Flu Plus Cough Night 2-pack", "Tylenol Cold Plus Flu Severe Day and Tylenol Cold Plus Flu Plus Cough Night 3-Pack", "Tylenol Cold Plus Flu Severe Day and Tylenol Cold Plus Flu Plus Cough Night 3-Pack", "Tylenol Cold plus Flu Severe and Tylenol Cold Max", "Tylenol Cold plus Flu Severe and Tylenol Cold Max", "TYLENOL Cold Plus Flu Severe and TYLENOL COLD MAX CoPack", "TYLENOL Cold Plus Flu Severe and TYLENOL COLD MAX CoPack", "Polytussin DM", "Sinus PE Head Congestion and Flu Severe", "Guaifenesin DM", "NightTime Cold and Flu Multi Symptom", "Sinex Severe plus Vicks VapoCool", "Daytime Cold and Flu", "Daytime Nighttime Cold Flu Relief", "Daytime Nighttime Cold Flu Relief", "Vapor Ice Daytime and Nitetime Cold and Flu", "Vapor Ice Daytime and Nitetime Cold and Flu", "Caring Mill Nighttime Cold and Flu", "Daytime Nighttime Cold and Flu", "Nocold-F", "Cough and Cold HBP", "Cold and Cough Childrens", "Sinus Relief Pressure, Pain and Cough", "Betr Cold and Flu Nighttime Relief", "Mucus Relief Cold Flu and Sore Throat", "Pressure and Pain Plus Cough PE", "Coricidin HBP Maximum Strength Cold, Cough and Flu", "Mucus Relief Cold and Flu All in One", "Coricidin HBP Maximum Strength Nighttime Cold and Flu", "Cold and Flu", "Pressure and Pain Plus Cold PE", "Betr Cold and Flu Daytime Relief", "Daytime Severe Cold and Flu", "Benylin Cough Plus Cold Relief", "Benylin Regular Strength Cough Plus Chest Congestion Relief", "Benylin for Children Cough & Cold", "Robitussin Cough Control", "Expectorant DM Cough Syrup", "Robitussin Children's Cough and Cold", "Robitussin Cough and Cold", "Robitussin Extra Strength Cough Control", "Robitussin Extra Strength Cough & Cold", "Hot Lemon Relief for Symptoms Of Cough and Cold", "Cough & Cold", "Children's Tylenol Cold and Cough", "Balminil DM + Expectorant", "Benylin Extra Strength All-IN-one Cold, Flu & Cough", "Balminil DM + Decongestant + Expectorant Extra Strength", "Balminil DM + Expectorant Extra Strength", "Balminil DM + Decongestant + Expectorant", "DM-decongestant-expectorant (extra Strength) Syrup", "DM-decongestant-expectorant Syrup", "DM-expectorant Syrup", "DM-decongestant Children's Syrup", "DM-decongestant Syrup", "Buckley's Complete Extra Strength Cough, Cold and Flu Night", "Balminil Night-time", "DM Expectorant (extra Strength) Syrup", "Dimetapp DM Cough & Cold", "Vicks NyQuil Cough", "Dimetapp Extra Strength DM Cough & Cold", "Benylin Extra Strength All-IN-one Cough, Cold & Flu", "Hot Lemon Relief for Symptoms Of Cough, Cold and Flu Extra Strength", "Extra Strength Flu Relief Daytime", "Nighttime Cold Relief Extra Strength Tablets", "Daytime Cold Relief Extra Strength Tablets", "Benylin Extra Strength All-IN-one Cough, Cold & Flu Night", "Cough and Chest Congestion Syrup", "Daytime Cold and Flu Relief", "Nighttime cold and flu relief", "Benylin Extra Strength Cough Complete", "Benylin Extra Strength Cough & Chest Congestion", "DM Cough and Cold Liquid", "DM + Expectorant Syrup", "DM + Expectorant Extra Strength Syrup", "Vicks Children's Nyquil Cold & Cough Multi-symptom Relief", "Regular Strength Tylenol Cold Daytime", "Extra Strength Tylenol Flu Daytime", "Histenol II", "Extra Strength Tylenol Cold Daytime", "Extra Strength Contac Complete Cough, Cold & Flu", "Extra Strength Tylenol Cold Nighttime", "Children's Tylenol Cold and Cough Nighttime", "Total Cold and Flu Extra Strength", "Daytime Cold/flu Medicine", "Dayquil Cold & Flu", "Coldaside Cold & Flu Extra Strength", "Benylin for Children All-IN-one Cold & Fever", "Benylin for Children All-IN-one Cold & Fever Nightime", "Coldaside Cough & Cold", "Benylin Extra Strength Mucus & Phlegm Plus Cough Control", "Benylin Extra Strength All-IN-one Cough, Cold & Flu With Warming Sensation", "Cough & Cold", "Daytime Cough & Cold", "Runny Nose and Cough", "Buckley's Complete + Mucus Relief", "Night Time Total Extra Strength", "Benylin All-IN-one Cold, Flu & Cough Liquid Gels", "Benylin Extra Strength Mucus & Phlegm Plus Cold Relief", "Extra Strength Tylenol Complete Cold, Cough & Flu", "Extra Strength Tylenol Complete Cold, Cough & Flu Plus Mucus Relief Nighttime", "Benylin Extra Strength Mucus & Phlegm Plus Cold Relief Night", "Extra Strength Tylenol Complete Cold, Cough & Flu Daytime", "Extra Strength Tylenol Complete Cold, Cough & Flu Plus Mucus Relief", "Benylin Extra Strength Mucus & Phlegm Plus Cold Relief", "Pain & Fever + Cold & Cough", "Vicks Nyquil Cold & Flu", "Children's Tylenol Complete Cold, Cough & Fever", "Nighttime cold and flu relief", "Robitussin Children's Cough & Cold Bedtime", "Mucus & Phlegm Relief With Cough Control Extra Strength", "Cough & Cold Relief", "Cough & Cold Relief Extra Strength", "Children's Cough & Cold Relief", "Cough & Chest Congestion Extra Strength", "Cough & Chest Congestion", "Vicks Dayquil Complete Cold & Flu Caplets", "Vicks Dayquil Complete Cold & Flu Liquid", "Vicks Nyquil Complete Cold & Flu", "Jack & Jill Cough & Cold", "Children's Tylenol Complete Cold, Cough & Fever Nighttime", "Calmylin Pediatric Syrup", "Children's Tylenol Cold Liquid With DM", "Histenol Cold Tablets", "Metrate", "Pharmacol DM Syr", "Vicks Formula 44d Liq", "Extra Strength Tylenol Cold and Flu Powder", "Personnelle Contre Le Rhume Liq", "Regular Strength Tylenol Cold and Flu Powder", "Dimetapp DM Elixir", "Calmylin #3 Syr", "Antitussive Decong Antihistamine Syr", "Calmylin #4 Syr", "Calmylin #2 Syr", "Tantacol DM Syr", "DM Expectorant Cough Syrup", "Theraflu Flu Cold and Cough Medicine", "Calmylin Cough and Flu Liq", "Dimetapp DM Tab", "Dayquil Liquicaps", "Non Drowsy Super Strength Contac Complete", "Demdec Syr", "Citron Chaud DM Option + Pws", "Citron Chaud DM Cumberland Pws", "Children's Nyquil Liquid", "Ornade DM 10 Liq", "Promatussin DM Adult Formula Syr", "Cough Syrup DM Decongestant Expectorant", "Cough Syrup DM Decongestant for Children", "Cough Syrup DM Decongestant Expectorant", "Cough Syrup DM Expectorant", "Koffex DM + Decongestant Syrup", "Personnelle DM Syr", "Actifed DM Tablets", "Nyquil Liquicaps", "Triaminic DM Daytime Syr", "Regular Strength Tylenol Cough Suspension With Decongestant", "Regular Strength Tylenol Cough Suspension", "Contac Cough Cold and Flu Caplets", "Ornade DM 30 Liq", "Neo Citran Daycaps Extra Strength - Caplet", "Cough Syrup DM Decongestant for Children", "Cough Syrup DM Expectorant", "Novahistine DM With Decongestant - Liq", "Novahistex DM Expectorant With Decongestant", "Robitussin Cough and Cold Liqui-gels", "Ornade DM 15 Liq", "Centracol DM - Syr", "Centracol Pediatrique - Syr", "Novahistine DM Expectorant With Decongestant", "DM Plus Decongestant Plus Expector.ex.st.syr", "DM Plus Decongestant Plus Expectorant Cough Syrup", "DM Plus Decongestant Cough Syrup", "DM Plus Expectorant Syrup", "Novahistex DM With Decongestant", "Regular Strength Cold Medication(daytime R.)", "Cough Syrup DM-E", "Cough Syrup DM-D-E", "Reg.str.cold Medic.(night Time Relief)caplet", "Sudafed Cold and Flu Gel Caps", "Vicks Nyquil Adult Nighttime Colds Medicine", "Pediatric Cough Syrup", "Cough and Flu Syrup", "Triaminicol DM Syrup", "Triaminic DM Expectorant Syr", "Robitussin Cough, Cold & Flu Liqui-gels", "Extra Strength Nighttime Cold Relief-caplet", "Extra Strength Daytime Cold Relief-caplet", "Sudafed Cold and Cough Extra Strength Caplet", "DM Plus Cough Syrup", "Triaminic DM Plus Decongestant Syrup", "Triaminic DM+decongestant Liqui-gels Capsules", "Cough Syrup DM-expectorant", "Cough Syrup DM Decongestant", "Cough Syrup DM Decongestant Expectorant", "Extra Strength Cold Medication Nighttime Rlf", "Extra Strength Cold Medication Daytime Rlf", "Benylin 4 Flu - Syrup", "Daytime Cold & Flu Liquid Capsules", "Nighttime Cold & Flu Liquid Capsules", "Syrup DM-D", "Syrup DM-E", "Cold Medication Reg Strength D Tab", "Cold Medication Reg Strength N Tab", "Vito Bronches Sirop", "Nighttime Cold and Flu Liquid Capsules", "Junior Strength Cold DM - Tablet", "Cough, Cold & Allergy Relief", "Syrup DM-D-E", "Neo Tuss Syr", "Dayquil Liquicaps - Cap", "Dimetapp Cough & Cold Liqui-gels - Cap", "Daytime Liquid - Liq", "Cough Syrup DM Decongestant Expectorant", "Actifed DM Syrup", "Bronchodex Fort-DM Syr", "Promatussin DM Children Formula", "Sudafed DM", "Dayquil Medicine - Liq", "Formule 115 DM", "Tussilyn DM", "Balminil DM-D-E - Liq", "Koffex DM-D-E - Liq", "Koffex DM + Expectorant", "Tussin Cough Medicine DM Antitussive Expectorant Decongestant", "Children's Tussin Cough Medicine DM Antitussive Decongestant", "Nitetime Cold Medicine", "DM-D-expectorant Cough and Cold Syrup", "Cold Relief DM", "Bronchodex Pediatrique", "Cold/flu Relief", "Koffex DM + Expectorant Extra Strength", "Koffex DM + Decongestant + Expectorant", "Koffex DM + Decongestant + Expectorant Extra Strength", "Pharmitussin DM", "Nite Time (children's)", "Pharminicol DM Syrup", "Daytime Cold & Flu Liquid Capsules", "Regular Strength Tylenol Cold Chest Congestion", "DM Cough Syrup", "Triaminic Softchews Throat Pain & Cough", "Nighttime cold and flu relief", "Dimetapp Cough, Cold & Flu", "Robitussin Honey Cough and Cold", "Robitussin Honey Flu", "Jack & Jill Cough and Cold", "Contac Cold and Sore Throat Caplets", "Dimetapp Cough & Congestion Liquid", "Dimetapp Children's Cough and Cold Liquid", "Total Cold and Flu", "Extra Strength Daytime Cold Relief", "Triaminic Cough", "Jack & Jill Cough, Cold & Flu Junior Strength Tablets", "Non Drowsy Regular Strength Contac Complete", "Daytime Cold and Flu Liquid Capsules", "Nighttime Cold and Flu Liquid Capsules", "Coricidin II Chest Congestion and Cough", "DM Syrup", "Vicks Dayquil Liquicaps", "Vicks Nyquil Liquicaps", "Benylin DM-D for Infants", "Neocitran Cold & Flu Syrup", "Neocitran Cough & Cold Syrup", "Contac Cold Nasal Congestion-nighttime", "Day Relief Cold and Flu Liquid Capsules", "Night Relief Cold and Flu Liquid Capsules", "Tylenol Cold & Flu Daytime", "Tylenol Cold & Flu Nighttime", "Daytime Cold/flu Relief", "Contac Cough & Cold Syrup", "Contac Complete Cough, Cold & Flu Syrup", "Little Colds Multi-symptom Cold Formula", "Little Colds Decongestant Plus Cough", "Cold and Flu Medicine - Day Time Formula", "Cold and Flu Medicine - Night Time Formula", "Contac Cough and Sore Throat Syrup", "Contac Night Cough Syrup", "Neocitran Thin Strips Daytime Cough and Cold", "Triaminic Toddler Cough and Cold Thin Strips", "Cold & Flu Daytime", "Cold & Flu Nighttime", "Cough", "Cold/flu Medicine", "Extra Strength Daytime Cold Relief PE", "Extra Strength Nighttime Cold Relief PE", "Extra Strength Daytime Flu PE", "Extra Strength Nighttime Flu PE", "Nighttime Cold & Flu Relief", "Zicam Multi-symptom Cold & Flu Daytime", "Zicam Multi-symptom Cold & Flu Nighttime", "Bronchosirum Pour Enfants", "Pulmorex DM Syr", "DM Cough Syrup Antitussive and Expectorant", "Children's Nicold Medicine", "Nicold Medicine for Adults", "Nitetime Cold Medicine", "Medicament Pour Le Rhume, Jour", "Medicament Pour Le Rhume, Nuit", "Benylin DM With Pectin Freezer Pops", "Day Time Liquid Caps", "Night Time Relief", "Cold & Cough", "Day Time Relief", "Cold & Flu", "Daytime 325 Liqua Caps", "Nighttime 325 Liqua Caps", "Cold Medication Regular Nighttime Tablets", "Cold & Cough Extra Strength", "Day Time Relief Extra Strength", "Nighttime Cold & Flu Relief Syrup", "Dry Cough & Cold Syrup", "Daytime Cold Relief Caplets", "A.M. Cold Relief Formula", "P.M. Cold Relief Formula", "Cough and Cold Medication Menthol Flavour", "Equate Daytime Liquid Capsules", "Equate Nighttime Liquid Capsules", "Sirop DM Expectorant", "Citron Chaud Réguliern DM", "Benylin Extra Strength With Menthactin", "Hot Lemon Relief for Sore Throat and Cough Extra Strength", "Toux Rhume Et Grippe (extra-fort)", "Cough Syrup DM Decongestant", "Cold and Flu-IN-one Regular Strength", "Cough Syrup DM Decongestant for Children", "Cough Syrup DM-decongestant Expectorant", "Cough Syrup DM-decongestant-expectorant Extra Strength", "Sudafed PE Total", "Complete One Cold and Flu Extra Strength", "Complete One Cold and Flu Extra Strength Tablets", "Cough Syrup DM Decongestant and Expectorant With Acetaminophen", "Cough Syrup DM Decongestant and Expectorant With Acetaminophen Extra Strength", "Nighttime Cough and Sore Throat Liquid", "Nighttime Cold Medicine", "Daytime Cold Relief Extra Strength", "Nighttime Cold and Flu Extra Strength Medicine", "Maux De Gorge Et De LA Toux Extra-fort", "Day Time Softgels", "Complete One Cold and Flu Nightime Extra Strength Liquid", "Nighttime Cold Relief Extra Strength Tablets PE", "Daytime Cold Relief Extra Strength Tablets PE", "Cold Medication Regular Nighttime Tablets PE", "Nitetime Cold Relief Extra Strength", "Grippe Extra Fort Jour", "Rhume Extra Fort Jour", "Grippe Extra Fort Nuit", "Rhume Extra Fort Nuit", "Acetaminophen/pseudoephedrine/dextromethorphan/doxylamine", "Acetaminophen/dextromethorphan/pseudoephedrine", "Cold and Cough Relief Extra Strength", "Cold and Flu Extra Strength Day", "Cold and Nasal Congestion Relief Nighttime Extra Strength", "Cough, Cold and Flu Relief Day Super Strength", "Daytime Flu Relief Extra Strength", "Daytime Symptom Relief Extra Strength for Symptoms Of Cold and Cough", "Hot Liquid Relief for Symptoms Of Cold and Cough", "Hot Lemon Night Time Total Extra Strength", "Rapid Action Cold", "Expectorant DM Cough Extra Strength", "Expectorant DM Cough Extra Strength With Decongestant", "Cold Relief Duo Pack", "Cold Relief Duo Pack", "Flu Multi Symptom Relief", "Flu Multi Symptom Relief", "Cold Multi Symptom Relief", "Cold Multi Symptom Relief", "Neocitran Total Cold", "Nightcap Complete Liquid Gels", "Daycap Cold & Sinus Liquid Gels", "Mucinex Multi-action Congestion, Stuffy Nose & Cough Liquid", "Mucinex Multi-action Wet & Dry Cough Liquid", "Mucinex Multi-action Congestion, Cold & Cough Solution", "Mucinex Multi-action Congestion, Cold & Cough", "Mucinex Multi-action Congestion & Cold Caplets", "Cough Control Extra Strength", "Vicks Nyquil Complete Cold & Flu Caplets", "Balminil DM + Decongestant", "Balminil Cough and Flu", "Cough Control", "Regular Strength Tylenol Cold Nighttime", "Robitussin Total Cough, Cold & Flu", "Robitussin Total Cough, Cold & Flu Nighttime Extra Strength", "Children's Tylenol Cold and Cough", "Junior Strength Tylenol Cold and Cough", "Benylin DM-D-E-A Cold and Sinus Liquid Gels", "Extra Strength Tylenol Flu Daytime", "Extra Strength Tylenol Congested Cough Caplets", "Benylin DM-D-AH for Children", "Benylin for Children Cough Stuffy and Runny Nose", "Benylin DM-D-AH Chewables for Children", "Benylin DM-D Chewables for Children", "Sudafed Total Cold and Flu Rapid Release", "Benylin DM-D-E Extra Strength With Menthactin", "Benylin Extra Strength All-IN-one Cold and Flu", "Tylenol Flu Daytime", "Tylenol Flu Nighttime", "Benylin Extra Strength All-IN-one Cold and Flu Nightime", "Children's Tylenol Cold and Cough", "Children's Tylenol Cold and Cough", "Extra Strength Tylenol Cold and Flu Daytime", "Tylenol Cold and Flu Nighttime", "Extra Strength Tylenol Cold and Flu Nighttime", "Junior Strength Tylenol Cold and Cough", "Benylin DM-D for Children", "Benylin DM-D", "Benylin DM-D-E", "Benylin 1 Nightime With Menthactin", "Benylin 1 With Menthactin", "Benylin DM-D-E With Menthactin", "Benylin DM-D With Menthactin", "Benylin All-IN-one Cold and Flu PE Caplets", "Sudafed PE Cold and Flu Caplets", "Children's Tylenol Cough and Runny Nose", "Benylin DM-D Soft Chews With Menthactin", "Benylin Cough and Congestion", "Benylin Cough and Cold", "Extra Strength Tylenol Cold Daytime", "Benylin for Children All-IN-one Cold and Fever", "Junior Strength Tylenol Complete Cold, Cough & Fever", "Extra Strength Tylenol Flu Nighttime", "DM Cough and Cold Liquid Cherry Flavour", "DM Cough and Cold Relief", "Cough Plus Cold Relief Syrup", "Daycap Cold and Flu Liquid Gels", "Nightcap Cold and Flu Liquid Gels", "Total Flu", "Viva Cold & Flu All In One Relief Caplets", "Sudafed Cold and Cough Extra Strength Caplets", "Neocitran Extra Strength Total Cold", "Neocitran Cold & Cough Night", "Benylin DM-D", "Triaminic Cold & Nighttime Cough", "Buckley's DM Decongestant", "Benylin Cough & Congestion Extra Strength", "Triaminic Cough and Sore Throat", "Extra Strength Neocitran Flu Night", "Triaminic Cold Cough and Fever", "Triaminic Softchews Cough and Cold", "Ultra Strength Neocitran Flu Day With Mucus Relief", "Triaminic Cough and Congestion", "Triaminic Cold and Cough", "Tylenol Cough", "Extra Strength Neocitran Total Night", "Extra Strength Neocitran Total Syrup", "Tylenol Cold and Flu Daytime", "Triaminic Daytime Cough & Cold", "Triaminic Cough and Sore Throat Softchews", "Triaminic Fever & Cough", "Tylenol Cold Rapid Release", "Regular Strength Tylenol Cold Nighttime Caplet", "Extra Strength Tylenol Cold Nighttime Caplet", "Regular Strength Tylenol Cold Daytime", "Jack & Jill Complete", "Nighttime Extra Strength Contac Complete Cough, Cold & Flu", "Cold Medication Extra Strength Daytime", "Cold Medication Extra Strength Night Time", "Sore Throat & Cough Ultra Strength", "Extra Strength Nighttime Cold Relief", "Extra Strength Day and Night Cold Medication", "Extra Strength Day and Night Cold Medication", "Triaminic Total Cold With Cough & Fever Relief", "Biohisdex DM Decongestant", "Biohisdine DM Decongestant", "Triaminic Thin Strips Cold & Cough", "Nighttime Extra Strength Contac Complete Cough, Cold & Flu Plus Vitamin C", "Buckley's Complete Daytime Softgels", "Jack & Jill Cough, Sore Throat & Fever", "Robitussin Sugar Free Cough Control", "Tylenol Complete Cold, Cough & Flu Plus Mucus Relief", "Extra Strength Tylenol Cough Caplets", "Total Cold & Flu", "Cough & Cold", "Extra Strength Cough Plus Cold Relief Syrup", "Neocitran Ultra Strength Total Flu Night", "Cold Flu Relief", "Extra Strength Mucous Relief Cough", "Cough, Cold & Flu", "Flu, Cough & Cold Complete Day and Night", "Daytime Cold & Flu Liquid Capsules", "Nighttime Cold & Flu Liquid Capsules", "Buckley's Nighttime Cold and Sinus", "Buckleys Cold & Sinus", "Cold & Flu-IN-one", "Cold & Flu", "Cold & Flu", "Flu Relief", "Cold Medication", "Cold Medication", "Vasofrinic Plus Sirop", "Benylin All-IN-one Cold & Flu Daytime", "Tylenol Complete Cold, Cough & Flu Nighttime", "Tylenol Complete Cold, Cough & Flu Daytime", "Benylin All-IN-one Cold & Flu Nighttime", "Daytime Complete", "Vicks Dayquil Cold & Flu Multi-symptom Relief Liquicaps", "Vicks Nyquil Liquicaps Cold & Flu Multi-symptom Relief", "Daytime Cold Medication Liquid Fastgels", "Complete Daytime Liquid Capsules", "Cough Syrup DM Expectorant Extra Strength", "Cough Syrup DM-D-E With Acetaminophen", "Cough Syrup DM-D-E With Acetaminophen Extra Strength", "Madame Pearl's Cough Syrup", "Tussodan DM Syrup", "Neocitran Ultra Strength Total Flu", "Cold & Flu Relief Nighttime", "Trialyn Syrup", "Pulmorphan", "Pulmorphan Pediatrique", "Cold and Flu Capsules", "Cough, Cold and Flu Daytime Caplets", "Extra Strength DM Cough and Cold Liquid", "Coricidin Cough & Cold", "Coricidin Cold & Flu Extra Strength", "Vicks Dayquil Cough Cough & Congestion", "Counteract Cough Medicine - Liq", "Guaitussin DM Syrup", "Nitetime Cold Medicine Original and Cherry", "Actifed DM Syrup", "Actifed DM Tablets", "Madame Pearl's Cough Syrup", "Benylin DM-D for Infants", "Coricidin Cold & Flu Multi-symptom", "Nighttime Complete", "Vicks Pediatric Formula 44e Liq", "Vicks Formula 44m Liq", "Vicks Custom Care Chest Congestion/cough", "Dayquil D", "Vicks Custom Care Nasal Congestion/cough", "Vicks Custom Care Cough & Cold PM", "Daytime Cold & Flu Relief", "Nighttime Cold & Flu Relief", "Cold Medication Daytime Relief", "Complete Liquid Capsules Nighttime Relief", "Benylin Extra Strength for People With Diabetes", "Cough & Cold Soft Gel Caps", "Daytime Cough. Cold. Flu Gel Capsules", "Nighttime Cough. Cold. Flu Gel Capsules", "Hot Lemon Relief for Symptoms Of Cough, Cold and Flu", "Hot Lemon Cough and Cold Relief DM", "Nighttime Total Super Strength", "Daytime Cold & Flu Relief", "Cold,sore Throat Pain & Cough Ultra Strength", "Cough, Cold & Flu Super Strength", "Colds & Coughs", "Day & Night Combo Pack", "Day & Night Combo Pack", "Prime's Sore Throat, Cough and Colds Capsules", "Buckley's Complete Cough, Cold & Flu Day", "DM Cough and Cold Liquid", "Vicks Pediatric Formula 44m Liq", "Guaitussin DM Cough Formula Syr", "Nitetime Cold Medicine Liq", "Cough Syrup DM Decongestant", "Cough Syrup DM - Decongestant - Expectorant", "Cough Syrup DM Expectorant", "Cough Syrup DM - Decongestant for Children", "Cough Syrup DM - Decongestant - Expectorant Extra Strength", "Hot Lemon Cough and Colds Relief DM", "Cold Relief Daytime Tablet", "Cold Relief Nightime Tablet", "Daytime Liqua Caps", "Nighttime Liqua Caps", "DM Cough and Cold Syrup", "Extra Strength DM Cough and Cold Syrup", "Extra Strength Cold Medication Day Time Relief", "Extra Strength Cold Medication Night Time Relief", "Benylin Extra Strength Cough & Chest Congestion With Warming Sensation", "Robitussin Complete Nighttime", "Robitussin Complete Daytime", "Vicks Pediatric Formula 44d Liq", "Complete Liquid Capsules", "Complete Liquid Capsules", "Buckley's Complete Relief", "Buckley's Complete Relief + Mucus", "Extra Strength Cold Medication Daytime Relief", "Extra Strength Cold Medication Nighttime Relief", "Cough and Chest Congestion Syrup Extra Strength", "Cold and Flu-IN-one Extra Strength", "Cold & Sinus Liquid Fastgels", "Cold and Sinus Complete Liquid Gels", "Complete", "Complete", "Coricidin Complete Cold, Cough & Flu", "Total Cold and Flu", "Buckley's Complete Nighttime Softgels", "Complete Daytime", "Cold & Sinus Liquid Capsules", "Cold & Sinus Liquid Capsules", "Night Time Multi Symptom Relief", "Day Time Multi Symptom Relief", "Cold and Flu Nighttime Relief Syrup Extra Strength", "Daytime Cold & Sinus", "Nighttime Relief Complete", "Nighttime Cold & Sinus", "Vicks NyQuil Cold and Flu", "Flu, Cough & Cold Complete", "Total Cold & Flu Combo", "Dr. Cocoa for Children Daytime Cough + Cold", "Buckley's Complete Extra Strength Cough, Cold & Flu Day", "Night Time Softgels", "Daytime Relief Complete", "Dayquil Complete + Vicks Vapocool", "Nyquil Complete + Vicks Vapocool", "Nyquil Complete + Vicks Vapocool Cold & Flu Liquid", "Dayquil Complete + Vicks Vapocool Cold & Flu Liquid", "Vicks Nyquil Complete Cold & Flu Liquicaps", "Vicks Dayquil Complete Cold & Flu Liquicaps", "Robitussin Honey Cough & Cold Nighttime", "Robitussin Extra Strength Honey Cough & Congestion", "Cough & Cold Relief", "Robitussin Honey Children's Cough & Congestion", "Hot Lemon Relief for Symptoms Of Cough, Cold and Flu Ultra Strength", "Daytime Relief Complete Liquid Gels", "Nighttime Cold & Flu Relief", "Complete Cold & Flu Relief", "Nighttime Cold & Flu Relief Liquid Gels", "Total Cold", "Total Flu Ultra Strength", "Buckley's Complete 24 Hour Pack", "Buckley's Complete 24 Hour Pack", "Daytime Cough Cold & Flu Liquid Gels", "Mucus Relief With Dextromethorphan", "Daycap Cold & Flu Liquid Gels", "Buckley's Cold & Sinus 24 Hour Pack", "Buckley's Cold & Sinus 24 Hour Pack", "Nightcap Complete Liquid Gels", "Daycap Cold & Sinus Liquid Gels", "Nightcap Cold & Flu Liquid Gels", "Nyquil Complete", "Dayquil Complete", "Hot Lemon Total Cold Extra Strength", "Hot Lemon Ultra Strength Total Flu", "Hot Lemon Ultra Strength Total Flu Night", "Cough and Cold Berry & Green Tea Flavor Extra Strength", "Hot Lemon Extra Strength Total Cold Night", "Tylenol Fever & Cough", "Extra Strength Tylenol Total Cough, Cold & Flu", "Coricidin Cold & Flu Liquid Gels", "Dayquil Cough DM + Congestion", "Jack & Jill Children's Formula Cough Liquid", "Daytime Cold", "Tussin cough and chest congestion", "Delsym Cough Relief Plus Soothing Action", "Delsym Cough Relief Plus Soothing Action", "Delsym Cough Plus Soothing Action", "First Aid Shot Therapy Cold Relief", "BestHealth Cough Relief Honey Lemon Flavor", "BestHealth Cough Relief Sugar Free Cherry Flavor", "TopCare Cough Relief Honey Lemon Flavor", "TopCare Cough Relief Sugar Free Cherry Flavor", "Chloraseptic Total Sore Throat and Cough, Sugar Free", "Chloraseptic Total Sore Throat and Cough", "CEPASTAT Sore throat and Cough", "CVS Pharmacy Cough Relief Honey Lemon Flavor", "Delsym Cough Plus Soothing Action", "Robitussin Medi-Soothers Cough DM", "Tussin Cough and Chest Congestion DM adult", "Pressure Pain and Cold Suphedrine PE", "Daytime Severe Cold and Flu", "Caring Mill Daytime Cold and Flu", "Circle K Daytime Cold and Flu", "Circle K Nighttime Cold and Flu", "Caring Mill Mucus DM", "Leader Tussin DM", "Circle K Daytime Cold and Flu", "Circle K Nighttime Cold and Flu", "Nighttime Cold and Flu", "Daytime Cold and Flu", "Mucinex DM", "Cold Relief", "Mucinex Fast-Max Day Cold and Flu and Night Cold and Flu Maximum Strength", "Mucinex Fast-Max Day Cold and Flu and Night Cold and Flu Maximum Strength", "Mucinex Sinus-Max Day and Night Maximum Strength", "Mucinex Sinus-Max Day and Night Maximum Strength", "Vicks NyQuil Severe Honey Cold and Flu", "Vicks DayQuil Severe Honey Cold and Flu", "Vicks Formula 44 VapoCool Cough and Chest Congestion", "Maximum Strength Severe Congestion Relief", "Tylenol Cold Plus Flu Severe", "Tylenol Cold Plus Flu Severe", "Basic Care Night Time Cough", "Daytime Nighttime Cold and Flu Relief Multi-Symptom", "Daytime Nighttime Cold and Flu Relief Multi-Symptom", "DrKids Children Multi Symptom Cold and Flu", "Mucus Relief DM", "Jack & Jill Honey Cough & Cold", "Jack & Jill Bedtime Honey Cough & Cold", "DrKids Childrens Multi Symptom Cold Cough and Congestion DM", "Rugby Cough Syrup", "Berkley and Jensen Tussin DM", "SanaTos Turbo Max Strength", "Nighttime Cold and Flu Liquid Gels", "Daytime Cold and Flu Liquid Gels", "Robafen DM", "Mucus Relief DM", "Mucus Relief DM", "Cough and Cold HBP", "Cough and Cold HBP", "Cold and Flu Nighttime Severe", "Firstcare Dextromethorphan Hydrobromide, Doxylamine Succinate", "Basic Care Nighttime Severe Cold and Flu", "Cold and Flu Daytime Severe", "Mucinex Childrens Cough and Chest Congestion Mini-Melts Orange Creme", "Complete Cold Relief", "Cough", "Histiacil Cough", "Guaifenesin and Dextromethorphan Hydrobromide", "Guaifenesin and Dextromethorphan HBr", "Brompheniramine Maleate, Pseudoephedrine Hydrochloride and Dextromethorphan Hydrobromide", "Mucus Relief Cough Childrens", "Caring Mill Daytime", "Guaifenesin and Dextromethorphan HBr", "Daytime Cold and Cough and NightTime Cold and Congestion Childrens", "Walgreen Cough and Chest Congestion", "Circle K Cold", "Covideze", "CVS Maximum Strength Cold and Flu Relief", "CVS Childrens Cough Relief", "Alka-Seltzer Plus Severe Cold and Cough PowerFast Fizz", "Good Sense Severe Tussin CF Max", "Sedalmex XL Flu", "Basic Care Nighttime Severe Cold and Flu", "Promethazine Hydrochloride and Dextromethorphan Hydrobromide Oral", "Basic Care Daytime Severe Cold and Flu", "Alka Seltzer Plus Maximum Strength Cough Chest Congestion PowerFast Fizz", "Alka-Seltzer Plus Severe Cold and Flu PowerFast Fizz", "Aspire Congestion and Cough Relief DM Softgels", "Tylenol Cold Plus Flu Severe", "Sinus Pressure, Pain and Cough", "Mucinex DM", "DayQuil Severe Plus Vicks Vapocool Cold and Flu", "NyQuil Severe Plus Vicks Vapocool Cold and Flu", "Childrens Mucus Relief Cough Cherry Liquid", "NIGHTTIME Cold and Flu Max Softgels MAXIMUM STRENGTH", "NON-DROWSY DAYTIME Cold and Flu Max Softgels MAXIMUM STRENGTH", "Guaifenesin and Dextromethorphan Hydrobromide", "Twkof Children", "Sunmark Adult Tussin DM", "Alka-Seltzer Plus Severe Cold PowerFast Fizz Day and Night", "Alka-Seltzer Plus Severe Cold PowerFast Fizz Day and Night", "Promethazine Hydrochloride and Dextromethorphan Hydrobromide Oral Solution", "Mucus Relief DM", "Cold and Flu Nighttime", "Discount Drugmart Chest Congestion Relief DM", "Cold and Flu Relief", "Nighttime Cold and Flu", "Cold and Flu Relief", "AXIM DayTime - Night Time 48 Softgels", "AXIM DayTime - Night Time 48 Softgels", "AXIM DayTime - Night Time 72 Softgels", "AXIM DayTime - Night Time 72 Softgels", "DEXTROMETHORPHAN HYDROBROMIDE and GUAIFENESIN", "DEXTROMETHORPHAN HYDROBROMIDE and GUAIFENESIN", "DEXTROMETHORPHAN HYDROBROMIDE and GUAIFENESIN", "Axim Night Time", "AXIM DayTime", "Vicks NyQuil Cold and Flu Nighttime Relief", "Vicks DayQuil Cold and Flu Multi-Symptom Relief", "Alka Seltzer Plus Severe Cold and Flu PowerFast Fizz", "Mucinex DM", "Cold and Flu Daytime Nighttime", "Cold and Flu Daytime Nighttime", "Mucus Relief DM Immediate Release", "Mucus Relief DM Immediate Release", "Basic Care Nighttime Severe Cold and Flu", "Basic Care Daytime Severe Cold and Flu", "Theraflu Daytime Severe Cold and Cough", "Good Sense Tussin DM", "SanaTos Multi Symptom", "Alka-Seltzer Plus Maximum Strength Cold and Cough Power Max Gels", "Daytime Nighttime Cold and Flu Relief Combo Pack", "Daytime Nighttime Cold and Flu Relief Combo Pack", "Tussin DM Max", "Guaifenesin and Dextromethorphan Hbr", "Guaifenesin and Dextromethorphan Hbr", "Daytime Nighttime Cold and Flu", "Daytime Nighttime Cold and Flu", "Severe Congestion, Cough, Cold and Flu Relief Maximum Strength, Nighttime", "Severe Congestion, Cough, Cold and Flu Relief Maximum Strength, Nighttime", "Maximum Strength Mucinex Sinus-Max Severe Congestion and Pain and Mucinex Nightshift Sinus", "Maximum Strength Mucinex Fast-Max Cold and Flu and Mucinex NightShift Severe Cold and Flu", "Maximum Strength Mucinex Fast-Max Cold and Flu and Mucinex NightShift Severe Cold and Flu", "Daytime and Nighttime Cold and Flu Maximum Strength", "Daytime and Nighttime Cold and Flu Maximum Strength", "DAYTIME NIGHTTIME SEVERE COLD AND FLU Maximum Strength", "DAYTIME NIGHTTIME SEVERE COLD AND FLU Maximum Strength", "Tussin", "Mucus Relief Cough and Congestion Childrens", "Daytime Nighttime Sinus Relief Maximum Strength", "Daytime Nighttime Sinus Relief Maximum Strength", "Nyquil Kids", "Alka-Seltzer Plus Maximum Strength Sinus, Congestion and Pain Power Max Gels", "Nitecin", "Activcin", "Walgreens Mixed Berry Benz-Dex Lozenges", "Pentrexcilina Night Time", "Ampigrin Ultra Forte Night", "Phenagil", "Giltuss TR", "Giltuss TR", "Phenagil", "Theraflu Flu Relief Max Strength Daytime Nighttime Combo Pack", "Theraflu Flu Relief Max Strength Daytime Nighttime Combo Pack", "Topcare Tussin DM", "Viro Flu PM Relief", "Sunmark Severe Nite Time Cold and Flu", "Daytime Nighttime", "Daytime Nighttime", "Mucinex Childrens Day Time Multi-Symptom Cold and Mucinex Childrens Night Time Multi-Symptom Cold Triple Pack", "Daytime", "Nightime", "good neighbor pharmacy adult tussin DM", "Sunmark Severe Day Time", "Dg Health Adult Tussin", "DAYTIME COLD AND FLU Maximum Strength", "Adult Cough and Chest Congestion", "NIGHTTIME COLD AND FLU Maximum Strength", "Alka Seltzer Plus Maximum Strength Sinus, Allergy And Cough Power Max Gels", "Theraflu Flu Relief Maximum Strength Daytime Nighttime Combo Pack", "Theraflu Flu Relief Maximum Strength Daytime Nighttime Combo Pack", "Coricidin HBP Maximum Strength Cold, Cough and Flu", "Vicks NyQuil Kids Honey Cold Cough Congestion", "Theraflu Flu Relief Max Strength Daytime Nighttime Value Pack", "Theraflu Flu Relief Max Strength Daytime Nighttime Value Pack", "Dollar General Chest Congestion Relief DM", "Tussin CF Max", "Tussin Cough and Chest Congestion", "Equaline Adult Tussin", "Equate Adult Cough and Chest Congestion DM", "Tussin DM", "Mucinex Fast-Max DM Max and Mucinex Nightshift Cold and Flu", "Mucinex Fast-Max DM Max and Mucinex Nightshift Cold and Flu", "Guaifenesin and Dextromethorphan Hydrobromide", "Mucinex Fast-Max Severe Congestion and Cough and Mucinex Nightshift Cold and Flu", "Mucinex Fast-Max Severe Congestion and Cough and Mucinex Nightshift Cold and Flu", "Tukol Children Cough and Congestion", "Guaifenesin and Dextromethorphan Hydrobromide HBR", "Mucus Relief DM Extended Release Caplets", "Mucinex Fast-Max Cold, Flu and Sore Throat and Mucinex NightShift Cold and Flu", "Mucinex Fast-Max Cold, Flu and Sore Throat and Mucinex NightShift Cold and Flu", "Mucinex Fast-Max Cold and Flu and Mucinex NightShift Cold and Flu", "Mucinex Fast-Max Cold and Flu and Mucinex NightShift Cold and Flu", "Maximum Strength Mucinex Fast-Max Cold and Flu and Mucinex NightShift Severe Cold and Flu", "Maximum Strength Mucinex Fast-Max Cold and Flu and Mucinex NightShift Severe Cold and Flu", "Vicks NyQuil HIGH BLOOD PRESSURE Cold and Flu", "Tusnel Cough Suppressant Expectorant", "Diphen", "Guaifenesin and Dextromethorphan HBr", "DEXTROMETHORPHAN HYDROBROMIDE and GUAIFENESIN", "DEXTROMETHORPHAN HYDROBROMIDE and GUAIFENESIN", "DEXTROMETHORPHAN HYDROBROMIDE and GUAIFENESIN", "Tussin CF", "Daytime Cold and Flu", "Careone Tussin DM", "Tylenol Cold Plus Flu Severe", "Tylenol Cold Plus Flu Severe", "Alka-Seltzer Plus Cold Day and Night PowerMax gels", "Alka-Seltzer Plus Cold Day and Night PowerMax gels", "Adult Tussin DM", "Sound Body Tussin DM", "Basic Care Tussin DM", "Nighttime Severe Cold and Flu", "Head Congestion Flu Severe PE", "Head Congestion Flu Severe PE", "Cold Max Nighttime", "Vicks childrens Cough Congestion", "Adult Tussin DM", "Adult Tussin DM", "First Aid Direct Cough Relief DM", "Severe Cold, Cold and Flu Maximum Strength, Daytime, Nightime", "Maximum Strength Cold, Flu and Sore Throat", "Maximum Strength Nighttime Sever Cold and Flu", "Maximum Strength Daytime Non Drowsy Severe Cold and Flu", "Head Congestion plus Flu Severe", "Vicks DayQuil Severe Hot Remedy Cold and Flu plus Congestion", "Akin Cough Formula DM", "Vicks NyQuil Severe Hot Remedy Cold and Flu plus Congestion", "Vicks NyQuil Severe Hot Remedy Cold and Flu plus Congestion", "Vicks DayQuil Severe Hot Remedy Cold and Flu plus Congestion", "Cold Severe Congestion", "Algidol Flu", "Algidol Flu", "Auvelity", "Alka-Seltzer Plus Cold and Flu", "Cold and Flu Non Drowsy Day Relief and Night Relief", "Cold and Flu Non Drowsy Day Relief and Night Relief", "Leader Tussin DM", "Nighttime Severe Cold and Flu", "Daytime Severe Cold and Flu", "Equate Health Non Drowsy DAY Cold and Flu Plus and NIGHTTIME Cold and Flu Plus", "Equate Health Non Drowsy DAY Cold and Flu Plus and NIGHTTIME Cold and Flu Plus", "Kroger Daytime Cold and Flu Softgel", "Kroger Nighttime Cold and Flu Softgel", "Kroger Daytime and Nighttime Cold and Flu Softgel", "Kroger Daytime and Nighttime Cold and Flu Softgel", "Daytime Cold and Flu", "Nightime Cold and Flu", "Cold and Flu Non Drowsy Daytime and Nighttime", "Cold and Flu Non Drowsy Daytime and Nighttime", "Cold and Flu Relief", "Walgreens Maximum Strength Non-Drowsy Day and Night Sinus and Cold", "Walgreens Maximum Strength Non-Drowsy Day and Night Sinus and Cold", "Walgreens Maximum Strength Non Drowsy Day and Night Cold and Flu", "Walgreens Maximum Strength Non Drowsy Day and Night Cold and Flu", "Robafen DM", "head congestion plus flu severe PE", "Medique Decorel Forte", "Medi-First Cough Cold", "Medi-First Plus Cough Cold", "Multi-Symptom Cold Relief", "Nighttime Cold and Flu Relief", "Medique Cold Cough Product", "Unishield Cough and Cold", "Medique at Home Decorel Forte", "Thompson Cough and Cold Multi-Symptom Relief", "Basic Care Daytime Nighttime Severe Cold and Flu", "Basic Care Daytime Nighttime Severe Cold and Flu", "Daytime Nighttime Cold Flu Relief", "Daytime Nighttime Cold Flu Relief", "Mucinex Cough Chest Congestion", "Coricidin HBP Maximum Strength Cold and Flu Day and Night", "Vicks Dayquil Hot Remedy", "Cold Max", "Cold plus Flu Severe", "Brompheniramine Maleate, Pseudoephedrine Hydrochloride, and Dextromethorphan Hydrobromide", "GUAIFENESIN AND DEXTROMETHORPHAN HBr", "BranTussin DM", "Cold and Flu Non Drowsy Daytime and Nighttime", "Cold and Flu Non Drowsy Daytime and Nighttime", "Cold and Flu Non Drowsy Daytime and Nighttime", "Cold and Flu Non Drowsy Daytime and Nighttime", "Cold and Flu Relief", "Nighttime Cold and Flu", "Cold Max Nighttime", "Head Congestion Plus Flu Severe PE", "Nighttime Cold and Flu", "cough and chest congestion DM syrup", "Mucus Relief DM Maximum Strength", "Mucus Relief DM", "Cough and Chest Congestion Maximum Strength", "Novalgina Children Cough and Cold", "Daytime Cold and Flu", "Daytime, Nighttime Severe Cold and Flu Relief", "Daytime, Nighttime Severe Cold and Flu Relief", "Vicks NyQuil Childrens", "Ed-A-hist DM", "COLDTAC Plus", "Non Drowsy Severe Daytime and Nighttime Cold and Flu Relief", "Non Drowsy Severe Daytime and Nighttime Cold and Flu Relief", "Twkof Adult", "Adult Tussin Cough and Chest Congestion DM Sugar Free", "Adult Tussin Cough and Chest Congestion DM", "Cold and Flu Day, Night", "Cold and Flu Day, Night", "Cold and Flu Day", "Cold and Flu Night", "Walgreen Adult Cough Plus Chest Congestion DM", "Walgreen Severe Multi-Symptom Cough Cold Flu", "Daytime Severe Cold and Flu", "Adult Tussin Cough and Chest Congestion DM Sugar Free", "Daytime Severe Cold and Flu Relief", "Head Congestion plus Flu Severe PE", "Mucus Relief Sinus Pressure Pain and Cough", "Head Congestion plus Flu Severe PE", "Good Sense Tussin DM", "Non-Drowsy Max Cold", "Daytime Cold and Flu", "Night Time Cold and Flu Relief", "Maximum Strength Non Drowsy Daytime Severe Cold and Flu", "Cold Max", "Cold plus Head Congestion", "Multi-symptom Daytime", "Multi-symptom Nitetime", "Multi-symptom Daytime", "Multi-symptom Daytime", "24/7 Life Cold and Flu DayTime Severe", "Cold and Flu Nighttime Severe", "Daytime Non Drows Cold and Flu and Nighttime Cold and", "Daytime Non Drows Cold and Flu and Nighttime Cold and", "NyQuil VapoCOOL SEVERE COLD and FLU plus CONGESTION", "Multi-symptom Nitetime", "DayQuil VapoCOOL SEVERE COLD and FLU plus CONGESTION", "Maximum Strength Severe Sinus Pressure, Pain and Cough Relief", "Dometuss-NR", "Vicks DayQuil COLD and FLU", "Vicks DayQuil VapoCOOL SEVERE COLD and FLU plus CONGESTION", "Mucinex Fast-Max Severe Congestion and Cough Clear and Cool and Maximum Strength Mucinex Nightshift Cold and Flu Clear and Cool", "Mucinex Fast-Max Severe Congestion and Cough Clear and Cool and Maximum Strength Mucinex Nightshift Cold and Flu Clear and Cool", "Vicks NyQuil VapoCOOL Severe COLD and FLU plus CONGESTION", "Severe Congestion and Cough, Cold and Flu Daytime, Nighttime", "Severe Congestion and Cough, Cold and Flu Daytime, Nighttime", "Tylenol Cold and Flu", "Alka-seltzer Plus Cold and Flu", "Dimacol", "Tukol Max Action Cold, Flu and Sore Throat", "Tussin DMMax", "Bromfed DM", "Pediacare Childrens Cough and Congestion Grape", "Pediacare Childrens Cough and Cold Grape", "Jack & Jill Bedtime Multi-symptom Cold & Cough", "Jack & Jill Multi-symptom Cold & Cough", "Nuedexta", "Vicks NyQuil COLD and FLU", "Vicks DayQuil Kids Honey and Vicks NyQuil Kids Honey COLD and COUGH plus", "Vicks DayQuil Kids Honey and Vicks NyQuil Kids Honey COLD and COUGH plus", "Nighttime Cold and Flu", "Vicks Childrens Cough Congestion", "Mucus Relief DM", "Tukol Day Time Cold and Flu Relief Softgels", "Tukol Night Time Cold and Flu Relief Softgels", "Childrens Robitussin Cough and Cold Long-acting", "Theraflu Severe Cold Relief Daytime and Theraflu Severe Cold Relief Nighttime", "Tukol Childrens Cold and Flu", "Good Sense Childrens Cold and Cough", "Good Sense Childrens Cold and Cough", "Rugby Cough Syrup", "Tylenol Cold Plus Flu Severe", "Brompheniramine Maleate, Pseudoephedrine Hydrochloride, and Dextromethorphan Hydrobromide", "CVS Severe Multi-Symptom Cough Cold Flu", "CVS NightTime Cold", "CVS Daytime Cold and Flu Relief", "Severe Cold", "Novalgina Pediatrico Cough and Cold Pediatrico", "Leader Tussin CF", "Always Save Chest Congestion Relief DM", "DG health mucus dm", "Rompe Pecho Nighttime", "Mucus Relief Cold and Flu Daytime Nighttime", "Akin Cough Formula DM Strawberry Banana", "Multi-symptom Nitetime", "HoneyWorks Plus Adult Nighttime Cough Syrup", "Childrens HoneyWorks Plus Nighttime Cough Syrup", "Multi-symptom Daytime", "Brompheniramine Maleate, Pseudoephedrine Hydrochloride and Dextromethorphan Hydrobromide", "Theraflu Flu Relief Max Strength Daytime", "Cvs Adult Cough Plus Chest Congestion DM", "Theraflu Flu Relief Max Strength Nighttime", "Daytime Cold and Flu Relief", "CVS Nighttime Cold and Flu Relief", "Dayquil Severe Plus Vapocool Cold and Flu", "Multi-Symptom Flu HBP", "Daytime Nighttime Cold Flu Relief", "Daytime Nighttime Cold Flu Relief", "CVS Maximum Strength", "Alka-Seltzer Plus Severe Cold and Flu PowerFast Fizz", "CVS Adult Cough plus Chest Congestion DM Max with Honey", "CVS Severe Cough, Flu Plus Sore Throat Honey", "CVS childrens Cough and Cold", "CVS Nighttime Childrens Cold and Cough Multi-Symptom Relief", "Childrens Dimetapp Cold and Cough", "Tussin Cough Chest Congestion", "Walgreens Childrens Cold plus Cough plus Runny Nose", "Handy Solutions Cold Relief", "Walgreen Childrens COLD PLUS COUGH PLUS SORE THROAT", "Tussin DM", "Walgreen Daytimel Kids Cold Cough plus Mucus", "Walgreens Maximum Strength Severe Congestion and Cough", "Walgreens Nighttime Kids Honey Cold Cough Congestion", "Alka-Seltzer Plus Severe Cold and Flu PowerFast Fizz", "Walgreens High Blood Pressure Cold and Flu", "Alka-Seltzer Plus Cold and Flu, BASIX", "Walgreen High Blood Pressure Nighttime Cold and Flu", "Promethazine Hydrochloride and Dextromethorphan Hydrobromide", "Mucus Relief DM", "Vicks DayQuil NyQuil HOT REMEDY RAPID RELIEF MULTI-SYMPTOM Cold and Flu plus Congestion", "Vicks DayQuil NyQuil HOT REMEDY RAPID RELIEF MULTI-SYMPTOM Cold and Flu plus Congestion", "Vicks DayQuil HOT REMEDY RAPID RELIEF MULTI-SYMPTOM Cold and Flu plus Congestion", "Vicks DayQuil HOT REMEDY RAPID RELIEF MULTI-SYMPTOM Cold and Flu plus Congestion", "Childrens Mucus and Cough Relief", "Nighttime Cold and Flu", "Night Time Cough", "Alka-Seltzer Plus Cold Day and Night PowerMax gels", "Alka-Seltzer Plus Cold Day and Night PowerMax gels", "Nighttime Cold and Flu", "Mucus Relief DM", "Daytime Cold and Flu", "WAG HBP Daytime and Nighttime Cold and Flu", "WAG HBP Daytime and Nighttime Cold and Flu", "Maximum Strength Non Drowsy Daytime Severe Cold and Flu", "CVS DayTime and NightTime Value Pack Cold and Flu", "CVS DayTime and NightTime Value Pack Cold and Flu", "Vicks DayQuil HIGH BLOOD PRESSURE Cold and Flu", "Leader Childrens Multi Symptom Cold", "Childrens Cold and Cough", "Tussin Nighttime Cough", "Mucus Relief DM", "Day-Time Cold and Flu Relief", "Non Drowsy DAY and NIGHT Multi-Symptom Cold and Flu Formula", "Non Drowsy DAY and NIGHT Multi-Symptom Cold and Flu Formula", "Night-Time Cold and Flu Relief", "Mucus Relief DM", "Mucus Relief Sinus Pressure Pain and Cough", "Tussin Severe", "Good Sense Tussin CF Max", "mucus relief DM", "Alka-Seltzer Plus Cold and Flu, CVP", "mucus relief DM MAX", "Foster and Thrive Chest Congestion Relief DM DM", "Head Congestion plus Flu Severe PE", "Head Congestion plus Flu Severe", "Cold plus Flu Severe", "Nyquil Severe Cold Flu", "Dayquil Cold Flu", "Dayquil Severe Cold Flu", "Nyquil Cold Flu", "Nyquil Cold Flu Relf Cherry", "Meijer Nitetime Cold and Flu Relief", "Meijer Children Cough and Chest Congestion DM Grape Flavor", "Meijer Adult Severe Multi-Symptom Cough Cold Flu", "Daytime Cold and Flu Relief Softgels Non-drowsy", "Mucinex-Sinus Max Severe Congestion and Pain Clear and Cool and Mucinex Nightshift Sinus Clear and Cool", "Nighttime Cold and Flu Relief Softgels Multi-symptom", "Daytime Severe Cold and Cough", "Cold and Flu Day and Night, Severe", "Cold and Flu Day and Night, Severe", "Non Drowsy Daytime and Nighttime Cold and Flu", "Non Drowsy Daytime and Nighttime Cold and Flu", "Theraflu Severe Cold Relief Daytime with Honey Ginger Flavor", "Medique Medi-Mucus", "Safetussin High Blood Pressure and diabetes Cough, Cold and Flu", "Theraflu Relief Max Strength Nighttime", "Walgreen NightTime Cold and Flu relief", "Theraflu Relief Max Strength Daytime", "Daytime Cold and Flu", "Multi Symptom Flu Relief Max Strength Daytime Nighttime Combo Pack", "Multi Symptom Flu Relief Max Strength Daytime Nighttime Combo Pack", "Vicks NyQuil Kids", "Overnight Cold and Flu", "Mucus Relief DM Honey and Berry Flavor", "DRx Choice Children daytime Cough and Chest Congestion", "Nyquil Severe Cold Flu", "Dayquil Cold Flu", "Dayquil Severe Cold Flu", "Nyquil Cold Flu", "Nyquil Cold Flu Relf Cherry", "Daytime Nighttime Cold Flu Relief", "Daytime Nighttime Cold Flu Relief", "DRx Choice maximum strength Severe Cough plus sore throat", "Childrens Mucus Cough and Congestion Relief", "Mucus Relief Cough Cold Sore Throat", "Cold and Flu Relief", "MAX Tussin Cough and Chest Congestion DM Sugar Free", "MAX Tussin Cough and Chest Congestion DM", "Vicks DayQuil and Vicks NyQuil COLD and FLU", "Vicks DayQuil and Vicks NyQuil COLD and FLU", "Vicks DayQuil and Vicks NyQuil HIGH BLOOD PRESSURE COLD and FLU", "Vicks DayQuil and Vicks NyQuil HIGH BLOOD PRESSURE COLD and FLU", "Cold and Flu Relief Daytime", "DayTime Cold and Flu", "Alka-Seltzer Plus Severe Cold Night PowerFast Fizz", "NightTime Cold and Flu", "DayTime and NightTime Cold and Flu", "DayTime and NightTime Cold and Flu", "Endal", "Severe Tussin CF", "Alka-Seltzer Plus Severe Cold Night PowerFast Fizz", "Topcare Tussin CF Max", "Maximum Strength Adult Cough plus Chest Congestion DM", "Childrens Cough and Cold", "Dg Health Tussin", "Mucus Relief - DM Maximum Strength", "Childrens Dimetapp Cold and Cough", "Vicks NyQuil Cold and Flu", "Daytime Non Drows Cold and Flu and Nighttime Cold and", "Daytime Non Drows Cold and Flu and Nighttime Cold and", "Vicks NyQuil Cold and Flu", "Vicks DayQuil Cold and Flu", "Tussin Severe Cough Cold Flu", "Alka-Seltzer Plus Severe Cold PowerFast Fizz Day and Night", "Alka-Seltzer Plus Severe Cold PowerFast Fizz Day and Night", "Basic Care Tussin CF Severe", "Vicks DayQuil and Nyquil VapoCOOL Severe COLD and FLU plus CONGESTION", "Vicks DayQuil and Nyquil VapoCOOL Severe COLD and FLU plus CONGESTION", "Basic Care Daytime Severe Cold and Flu Nighttime Severe Cold Cough and Flu", "Robitussin Medi-Soothers", "Vicks DayQuil NyQuil Severe Honey Cold and Flu", "Vicks DayQuil NyQuil Severe Honey Cold and Flu", "Robitussin Medi-Soothers", "Severe Cold DM", "Promethazine Hydrochloride and Dextromethorphan Hydrobromide", "Alka-Seltzer Plus Severe Cold PowerFast Fizz Day and Night", "Alka-Seltzer Plus Severe Cold PowerFast Fizz Day and Night", "Tussin CF Max", "Severe Cold DM Severe Cold and Flu", "Mucinex Fast-Max Kickstart Severe Cold and Flu", "Polytussin DM", "Mucinex Night Time Severe Cold and Flu", "Alahist DM", "Multi-Symptom Cold childrens", "MUCINEX FAST MAX Liquid Cold and Flu Kickstart and MUCINEX Nightshift Kickstart", "MUCINEX FAST MAX Liquid Cold and Flu Kickstart and MUCINEX Nightshift Kickstart", "Nyquil Severe Cold Flu", "Dayquil Cold Flu", "Dayquil Severe Cold Flu", "Nyquil Cold Flu", "Nyquil Cold Flu Relf Cherry", "Dextromethorphan HBr. and Guaifenesin", "Dextromethorphan HBr. and Guaifenesin", "SAFETUSSIN Non Drowsy Cough plus chest congestion", "Kirkland Signature Mucus DM", "Mucinex Fast-Max Day Cold and Flu and Night Cold and Flu Maximum Strength", "Mucinex Fast-Max Day Cold and Flu and Night Cold and Flu Maximum Strength", "Extra Strength TYLENOL Severe Cough Plus Sore Throat Night", "Leader Daytime Severe Cold and Flu Relief", "Vicks NyQuil Kids BERRY COLD and COUGH plus RUNNY NOSE", "Daytime Nighttime Severe Cold and Flu Relief", "Vicks DayQuil Kids BERRY COLD and COUGH plus MUCUS", "Mucus DM Fast Max Day Cold and Flu and Night Cold and Flu", "Mucus DM Fast Max Day Cold and Flu and Night Cold and Flu", "Daytime Cold and Flu", "Daytime Nighttime Cold Flu Relief", "Daytime Nighttime Cold Flu Relief", "Sinus Pressure, Pain and Cough", "Nighttime Cold and Flu Relief", "Severe Cold and Flu Plus Congestion", "Severe Cold and Flu Plus Congestion", "Daytime Cold and Flu", "Mucus Relief DM", "Coldtac Plus Softgels", "Desresfriol-DX Softgels", "Foster and Thrive Daytime Severe Cold and Flu Relief", "Daytime cold and flu", "Foster and Thrive Nighttime Severe Cold and Flu Relief", "Daytime Nighttime Cold and Flu", "Daytime Nighttime Cold and Flu", "Vicks DayQuil ULTRA CONCENTRATED COLD and FLU", "Vicks DayQuil HIGH BLOOD PRESSURE COLD and FLU", "Vicks NyQuil ULTRA CONCENTRATED COLD and FLU", "Dexbrompheniramine-DM-Phenylephrine 2-15-7.5", "Promethazine Hydrochloride and Dextromethorphan Hydrobromide", "Multi Symptom Severe Cold", "Bromfed DM", "DayTime Cold and Flu Relief", "Topcare Nite Time Cold and Flu", "Daytime Severe Cold and Flu", "Good Sense Day Time Cold and Flu", "WesTussin DM NF", "Cough & Chest Congestion", "DayTime Severe Cold and Flu Relief", "Family Dollar Daytime Cold and Flu Relief", "Family DollarSevere Nighttime Cold and Flu", "Cvs Sugar Free Adult Cough Plus Chest Congestion DM", "Mucinex DM Maximum Strength", "Family Dollar Nighttime Cold and Flu Relief Original Flavor", "Family Dollar Nighttime Cold and Flu Relief", "Daytime Cold and Flu Relief", "Cold and Flu Daytime Nighttime", "Cold and Flu Daytime Nighttime", "Rompe Pechito DM for Kids", "Day and Night Cold Symptom Relief", "Day and Night Cold Symptom Relief", "Guaifenesin and Dextromethorphan HBr", "Tussin DM Nighttime", "Cold Multi-Symptom Severe", "Tussin DM Daytime", "Cough & Congestion", "Good Neighbor Pharmacy Dye Free Severe Cold Multi-Symptom", "Mucus Relief DM Cough", "Vicks NyQuil HIGH BLOOD PRESSURE COLD and FLU", "Tussin DM Daytime Nighttime", "Tussin DM Daytime Nighttime", "Daytime Cold and Flu and Nigttime Cold and Flu", "Daytime Cold and Flu and Nigttime Cold and Flu", "Nighttime cold and flu relief", "CVS DT and NT Combo Pack Cold and Flu", "CVS DT and NT Combo Pack Cold and Flu", "Kids Cough and Chest Congestion", "Nighttime Severe Cold and Flu", "Mucus Relief Severe Congestion and Cough", "CETAFEN COUGH and COLD", "Good Sense Night Time Cold and Flu", "DG Health DayTime SEVERE Cold and Flu", "Mucus Relief Cold, Flu and Sore Throat", "DG Health NightTime SEVERE Cold and Flu", "Safetussin PM Nighttime Cough relief", "Promethazine Hydrochloride and Dextromethorphan Hydrobromide Oral", "Nighttime Cough-Kids", "Guaifenesin and Dextromethorphan HBR", "Guaifenesin and Dextromethorphan HBR", "Multi-Symptom Cold and Flu-Kids", "Guaifenesin and Dextromethorphan HBR", "Cold and Flu plus Congestion Daytime", "Vicks DayQuil NyQuil ULTRA CONCENTRATED COLD and FLU", "Vicks DayQuil NyQuil ULTRA CONCENTRATED COLD and FLU", "Cold and Flu plus Congestion Nighttime", "Vicks DayQuil NyQuil BERRY Kids COLD and COUGH plus", "Vicks DayQuil NyQuil BERRY Kids COLD and COUGH plus", "Tussin CF", "Daytime Cold and Flu Severe, Caseys 4goog", "Brompheniramine Maleate, Pseudoephedrine Hydrochloride and Dextromethorphan Hydrobromide", "Rugby Chest Congestion Relief DM", "DayQuil and NyQuil VapoCOOL SEVERE COLD and FLU plus CONGESTION", "DayQuil and NyQuil VapoCOOL SEVERE COLD and FLU plus CONGESTION", "Vicks DayQuil NyQuil HIGH BLOOD PRESSURE COLD and FLU", "Vicks DayQuil NyQuil HIGH BLOOD PRESSURE COLD and FLU", "Kids Cough Daytime Nighttime Combo", "Kids Cough Daytime Nighttime Combo", "Up and Up Nighttime Severe Cold and Flu", "Vicks NyQuil Alcohol Free Cold and Flu Nighttime Relief", "DG Health Cold and Flu Severe", "Mucinex Fast-Max Cold and Flu Arctic Burst and Nightshift Severe Cold and Flu Arctic Burst", "Mucinex Fast-Max Cold and Flu Arctic Burst and Nightshift Severe Cold and Flu Arctic Burst", "Severe Cold and Flu Relief", "Topcare Day Time Cold and Flu", "Mucus & Phlegm Relief With Cough Control Extra Strength", "Total Cold & Flu Extra Strength Night", "Cough & Cold Relief Regular Strength", "Cough & Cold Relief Extra Strength", "VICKS DayQuil SEVERE HONEY FLAVOR COLD and FLU", "VICKS NyQuil SEVERE HONEY FLAVOR COLD and FLU", "Theraflu Severe Cold relief Nighttime", "Family Dollar Daytime and Nighttime Combo Pack Cold and Flu", "Family Dollar Daytime and Nighttime Combo Pack Cold and Flu", "Vicks DayQuil and Vicks NyQuil Cold and Flu", "Vicks DayQuil and Vicks NyQuil Cold and Flu", "Daytime Severe", "VICKS FORMULA 44DM COUGH and CHEST CONGESTION", "Equate Cold and Flu", "VICKS FORMULA 44DM NIGHTTIME COUGH and COLD", "Promethazine Hydrochloride and Dextromethorphan Hydrobromide Oral Solution", "Foster and Thrive Childrens Cold and Cough Relief DM", "Tussin Multi Symptom Cold CF Adult", "Tussin Multi Symptom Cold CF Adult", "Rompe Tos X Children", "Cold and Flu Daytime Severe, 24/7 Life", "Tenalif Multi Symptom Relief", "Tenalif Children", "Rompe Tos X Adults", "Severe Cold and Flu Relief", "Cold and Flu Nighttime Severe, 24-7 Life", "Siltussin DM DAS Cough Formula", "Vicks NyQuil childrens COLD and COUGH", "Nighttime Severe", "Family Wellness Chest Congestion Relief DM DM", "DayQuil Severe plus VapoCOOL Cold and Flu, CVP HEALTH", "DayQuil Severe plus VapoCOOL Cold and Flu, Travel BASIX", "Tabcin Extra Strength", "Cough & Chest Congestion Regular Strength", "Cough & Chest Congestion Extra Strength", "Equate Nighttime Cold and Flu", "Guaifenesin and Dextromethorphan Hydrobromide", "DG Health Cold and Flu Severe", "Mucinex DM, CVP HEALTH", "Mucinex DM, TRAVEL BASIX", "Accu Tuss DM", "Promethazine Hydrochloride and Dextromethorphan Hydrobromide", "Nyquil Cough DM + Congestion", "Mucus Relief DM", "Promethazine Hydrochloride and Dextromethorphan Hydrobromide Oral Solution", "Mucus Relief DM", "Guaifenesin and Dextromethorphan HBR", "Guaifenesin and Dextromethorphan HBR", "Members Mark Mucus Relief DM", "Cough and Congestion Extended Release", "Maximum Strength Cough and Congestion Extended Release", "Tylenol Cold Nightime Rapid Release", "Amazon Basic Care Mucus DM", "Guaifenesin and Dextromethorphan HBr", "Guaifenesin and Dextromethorphan HBr", "Children's Cough & Cold Relief", "Daytime Cold Relief Liquid Gels", "Nyquil Kids Honey", "Guaifenesin and Dextromethorphan HBr", "Mucus Relief DM", "Nighttime Cold & Flu Relief", "Mucus Relief DM", "Mucus Relief DM", "Good Sense Mucus DM", "Total Cough, Cold & Flu Ultra Strength", "Nyquil Cold & Flu Alcohol Free", "Brompheniramine Maleate, Pseudoephedrine Hydrochloride, and Dextromethorphan Hydrobromide", "meijer Daytime and Nighttime Cold and Flu SOFTGEL", "meijer Daytime and Nighttime Cold and Flu SOFTGEL", "Promethazine Hydrochloride and Dextromethorphan Hydrobromide", "Vicks Dayquil Cold & Flu", "Neocitran Extra Strength Cold & Cough", "Nyquil Honey", "Mucus Fast Max Day Cold and Flu and Night Cold and Flu", "Mucus Fast Max Day Cold and Flu and Night Cold and Flu" ]	[ "Q99720", "P11511", "Q8TCU5", "Q15822", "P31645", "O00264", "P32297", "P43681", "P30926", "P17787", "P36544", "P35372", "P41143", "P41145", "P04839", "P13498", "P14598", "P19878", "Q15080", "P63000", "P15153", "P23975" ]	[ "P10635", "P08684", "P24462", "P20813", "P33261", "P11712", "P06133", "P16662", "P54855", "O75795" ]	[]	[]
DB00515	Cisplatin	Cisplatin, cisplatinum or cis-diamminedichloroplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. It was the first member of its class, which now also includes carboplatin and oxaliplatin.	solid	For the treatment of metastatic testicular tumors, metastatic ovarian tumors and advanced bladder cancer.	Cisplatin is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer. Alkylating agents are so named because of their ability to add alkyl groups to many electronegative groups under conditions present in cells. They stop tumor growth by cross-linking guanine bases in DNA double-helix strands - directly attacking DNA. This makes the strands unable to uncoil and separate. As this is necessary in DNA replication, the cells can no longer divide. In addition, these drugs add methyl or other alkyl groups onto molecules where they do not belong which in turn inhibits their correct utilization by base pairing and causes a miscoding of DNA. Alkylating agents are cell cycle-nonspecific. Alkylating agents work by three different mechanisms all of which achieve the same end result - disruption of DNA function and cell death.	Alkylating agents work by three different mechanisms: 1) attachment of alkyl groups to DNA bases, resulting in the DNA being fragmented by repair enzymes in their attempts to replace the alkylated bases, preventing DNA synthesis and RNA transcription from the affected DNA, 2) DNA damage via the formation of cross-links (bonds between atoms in the DNA) which prevents DNA from being separated for synthesis or transcription, and 3) the induction of mispairing of the nucleotides leading to mutations.	Following cisplatin doses of 20 to 120 mg/m^2, the concentrations of platinum are highest in liver, prostate, and kidney; somewhat lower in bladder, muscle, testicle, pancreas, and spleen; and lowest in bowel, adrenal, heart, lung, cerebrum, and cerebellum. Platinum is present in tissues for as long as 180 days after the last administration.	null	null	Cisplatin decays monoexponentially with a half life of 20 to 30 minutes following administrations of 50 or 100 mg/m^2. Cisplatin has a plasma half-life of 30 minutes. The complexes between albumin and the platinum from cisplatin do not dissociate to a significant extent and are slowly eliminated with a minimum half-life of five days or more.	Cisplatin does not undergo instantaneous and reversible binding to plasma protein that is characteristic of normal drug-protein binding. However, the platinum itself is capable of binding to plasma proteins, including albumin, transferrin, and gamma globulin. Three hours after a bolus injection and two hours after the end of a three-hour infusion, 90% of the plasma platinum is protein bound.	The parent compound, cisplatin, is excreted in the urine. Although small amounts of platinum are present in the bile and large intestine after administration of cisplatin, the fecal excretion of platinum appears to be insignificant.	Volume of distribution at steady state = 11-12 L/m^2	* 15-16 L/h/m^2 [total body clearance, 7-hour infusion of 100 mg/m^2] * 62 mL/min/m^2 [renal clearance, 2-hour infusion of 100 mg/m^2] * 50 mL/min/m^2 [renal clearance, 6- to 7-hour infusion of 100 mg/m^2] The renal clearance of free (ultrafilterable) platinum also exceeds the glomerular filtration rate indicating that cisplatin or other platinum-containing molecules are actively secreted by the kidneys. The renal clearance of free platinum is nonlinear and variable and is dependent on dose, urine flow rate, and individual variability in the extent of active secretion and possible tubular reabsorption.	Inorganic compounds	Mixed metal/non-metal compounds	Transition metal salts	Transition metal chlorides	[ "approved" ]	[ "L01XA", "L01X", "L01", "L" ]	[ "Humans and other mammals" ]	[ { "cost": "0.41", "description": "Cisplatin 1 mg/ml vial", "unit": "ml" } ]	[]	(SP-4-2)-DIAMMINEDICHLOROPLATINUM \| CDDP \| Cis-DDP \| CIS-DIAMMINEDICHLOROPLATINUM \| CIS-DIAMMINEDICHLOROPLATINUM II \| cis-diamminedichloroplatinum(II) \| Cisplatin \| cisplatino \| INT-230-6 COMPONENT CISPLATIN \| INT230-6 COMPONENT CISPLATIN \| PLATINUM, DIAMMINEDICHLORO-, (SP-4-2)- \| 3-alkyladenine DNA glycosylase \| 3-methyladenine DNA glycosidase \| 3.2.2.21 \| AAG \| ADPG \| ANPG \| MID1 \| N-methylpurine-DNA glycosylase \| Alpha-2-M \| C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5 \| CPAMD5 \| Beta-1 metal-binding globulin \| Siderophilin \| Transferrin \| HAH1 \| Metal transport protein ATX1 \| 1.11.2.2 \| MPO \| XDHA \| 1.14.14.1 \| 20-HETE synthase \| 20-hydroxyeicosatetraenoic acid synthase \| CYP4A2 \| CYP4AII \| CYPIVA11 \| Cytochrome P-450HK-omega \| Cytochrome P450HL-omega \| Fatty acid omega-hydroxylase \| Lauric acid omega-hydroxylase \| Long-chain fatty acid omega-monooxygenase \| 1.14.99.1 \| COX-2 \| COX2 \| Cyclooxygenase-2 \| PGH synthase 2 \| PGHS-2 \| PHS II \| Prostaglandin H2 synthase 2 \| Prostaglandin-endoperoxide synthase 2 \| 2.3.1.5 \| NAT \| nhoA \| tbnat \| (R)-limonene 6-monooxygenase \| (S)-limonene 6-monooxygenase \| (S)-limonene 7-monooxygenase \| 1.14.14.1 \| Cholesterol 25-hydroxylase \| CYP2C10 \| CYPIIC9 \| Cytochrome P-450MP \| Cytochrome P450 MP-4 \| Cytochrome P450 MP-8 \| Cytochrome P450 PB-1 \| S-mephenytoin 4-hydroxylase \| 1,4-cineole 2-exo-monooxygenase \| 1.14.13.- \| CYPIIB6 \| Cytochrome P450 IIB1 \| 3.1.1.8 \| Acylcholine acylhydrolase \| Butyrylcholine esterase \| CHE1 \| Choline esterase II \| Pseudocholinesterase \| 2.5.1.18 \| Glutathione transferase T1-1 \| GST class-theta-1 \| Metallothionein-IA \| MT-1A \| MT-IA \| MT1S \| CES1 \| Metallothionein-2A \| Metallothionein-II \| MT-2 \| MT-II \| MT2 \| 1.15.1.1 \| hSod1 \| Superoxide dismutase 1 \| 2.5.1.18 \| FAEES3 \| GST class-pi \| GST3 \| GSTP1-1 \| 1.6.5.2 \| Azoreductase \| DIA4 \| DT-diaphorase \| DTD \| Menadione reductase \| NAD(P)H:quinone oxidoreductase 1 \| NMOR1 \| Phylloquinone reductase \| QR1 \| Quinone reductase 1 \| 2.5.1.18 \| GST class-mu 1 \| GST HB subunit 4 \| GST1 \| GSTM1-1 \| GSTM1a-1a \| GSTM1b-1b \| GTH4 \| 7.6.2.- \| 7.6.2.2 \| 7.6.2.3 \| Canalicular multispecific organic anion transporter 2 \| CMOAT2 \| MLP2 \| MOAT-D \| MRP3 \| Multi-specific organic anion transporter D \| Multidrug resistance-associated protein 3 \| 7.6.2.- \| 7.6.2.2 \| MOAT-C \| MRP5 \| Multi-specific organic anion transporter C \| Multidrug resistance-associated protein 5 \| pABC11 \| SMRP \| 7.6.2.- \| 7.6.2.2 \| 7.6.2.3 \| Canalicular multidrug resistance protein \| Canalicular multispecific organic anion transporter 1 \| CMOAT \| CMOAT1 \| CMRP \| MRP2 \| Multidrug resistance-associated protein 2 \| hOCT2 \| OCT2 \| Organic cation transporter 2 \| Copper transporter 1 \| COPT1 \| CTR1 \| hCTR1 \| Solute carrier family 31 member 1 \| Copper transporter 2 \| COPT2 \| CTR2 \| hCTR2 \| Solute carrier family 31 member 2 \| 7.6.2.- \| 7.6.2.3 \| Anthracycline resistance-associated protein \| ARA \| MOAT-E \| MRP6 \| Multi-specific organic anion transporter E \| Multidrug resistance-associated protein 6 \| 7.2.2.8 \| Copper pump 2 \| PWD \| WC1 \| Wilson disease-associated protein \| WND \| 7.2.2.8 \| Copper pump 1 \| MC1 \| Menkes disease-associated protein \| MNK \| 7.6.2.2 \| ABCP \| ATP-binding cassette sub-family G member 2 \| BCRP \| BCRP1 \| Breast cancer resistance protein \| CDw338 \| Mitoxantrone resistance-associated protein \| MXR \| Placenta-specific ATP-binding cassette transporter \| Urate exporter	[ "Cisplatin", "Cisplatin", "Cisplatin", "Cisplatin", "Cisplatin", "Cisplatin", "Cisplatin", "Cisplatin", "Cisplatin", "Cisplatin", "Cisplatin", "Cisplatin", "Cisplatin", "CISplatin", "CISplatin", "Cisplatin", "Cisplatin", "Cisplatin", "Cisplatin", "CISplatin", "CISplatin", "CISplatin", "Cisplatin", "Cisplatin", "CISplatin", "Cisplatin", "Cisplatin", "Cisplatin", "Cisplatin", "Cisplatin", "Cisplatin", "CISplatin", "Cisplatin Inj 0.5mg/ml", "Cisplatin Inj 1mg/ml", "Cisplatin Injection", "Cisplatin Injection", "Cisplatin Injection", "Cisplatin Injection", "Cisplatin Injection BP", "Cisplatin Injection BP", "Cisplatin Injection BP", "Cisplatin Injection, BP", "Cisplatin Injection, Mylan Std.", "Platinol", "Platinol", "Platinol", "Platinol AQ Inj 1mg/ml", "Platinol-AQ", "PMS-cisplatin" ]	[ "Abiplatin", "Cisplatyl", "Platidiam", "Platin" ]	[]	[ "P29372", "P01023", "P02787", "O00244" ]	[ "P05164", "P47989", "Q02928", "P35354", "P11712", "P20813", "P06276", "P30711", "P04731", "P02795", "P00441", "P09211", "P15559", "P09488" ]	[ "P02768" ]	[ "O15438", "O15440", "Q92887", "O15244", "O15431", "O15432", "O95255", "P35670", "Q04656", "Q9UNQ0" ]
DB00516	Bentoquatam	Bentoquatam is a topical medication intended to act as a shield against exposure to the irritating substance urushiol, found in plants such as poison ivy or poison oak. Bentoquatam contains bentonite, a clay, and is only effective as long as the film is visible on the skin.	solid	Used to prevent or reduce the severity of allergic contact dermatitis due to urushiol, the allergenic resin of poison ivy, poison oak, and poison sumac.	Bentoquatam protects the skin like a shield against poison ivy, poison oak, and poison sumac by physically blocking skin contact with their resin. The best protection against getting these conditions is to avoid contact with these plants. This medicine does not dry oozing and weeping caused by the rash of poison ivy, poison oak, or poison sumac.	The mechanism of action is unknown. It is thought topically applied bentoquatam acts as a physical barrier that interferes with the adsorption of antigens onto the skin and reduces absorption of antigens into the skin. It probably does not work by modifying the systemic allergic response.	null	null	Rare side effects include mild erythema (mild redness of skin).	null	null	null	null	null	null	null	null	null	[ "approved" ]	[]	[ "Humans and other mammals" ]	[]	[]	Bentoquatam	[]	[ "IvyBlock" ]	[]	[]	[]	[]	[]
DB00517	Anisotropine methylbromide	Anisotropine methylbromide is a quaternary ammonium compound. Its use as treatment adjunct in peptic ulcer has been replaced by the use of more effective agents. Depending on the dose, anisotropine methylbromide may reduce the motility and secretory activity of the gastrointestinal system, and the tone of the ureter and urinary bladder and may have a slight relaxant action on the bile ducts and gallbladder. In general, smaller doses of anisotropine methylbromide inhibit salivary and bronchial secretions, sweating, and accommodation; cause dilatation of the pupil; and increase the heart rate. Larger doses are required to decrease motility of the gastrointestinal and urinary tracts and to inhibit gastric acid secretion.	solid	For use in conjunction with antacids or histamine H<sub>2</sub>-receptor antagonists in the treatment of peptic ulcer, to reduce further gastric acid secretion and delay gastric emptying.	Anisotropine methylbromide is a quaternary ammonium compound. Its use as treatment adjunct in peptic ulcer has been replaced by the use of more effective agents. Depending on the dose, anisotropine methylbromide may reduce the motility and secretory activity of the gastrointestinal system, and the tone of the ureter and urinary bladder and may have a slight relaxant action on the bile ducts and gallbladder. In general, smaller doses of anisotropine methylbromide inhibit salivary and bronchial secretions, sweating, and accommodation; cause dilatation of the pupil; and increase the heart rate. Larger doses are required to decrease motility of the gastrointestinal and urinary tracts and to inhibit gastric acid secretion.	Quaternary ammonium compounds such as anisotropine methylbromide inhibit the muscarinic actions of acetylcholine on structures innervated by postganglionic cholinergic nerves as well as on smooth muscles that respond to acetylcholine but lack cholinergic innervation. These postganglionic receptor sites are present in the autonomic effector cells of the smooth muscle, cardiac muscle, sinoatrial and atrioventricular nodes, and exocrine glands.	Gastrointestinal absorption is poor and irregular. Total absorption after an oral dose is about 10 to 25%.	Hepatic, by enzymatic hydrolysis.	null	Not Known	Not Known	null	null	null	Organic compounds	Alkaloids and derivatives	Tropane alkaloids	null	[ "approved" ]	[]	[ "Humans and other mammals" ]	[]	[]	8-Methyl-3-(2-propylpentanoyloxy)tropinium bromide \| 8-Methyltropinium bromide 2-propylpentanoate \| 8-Methyltropinium bromide 2-propylvalerate \| Anisotropine methobromide \| Anisotropine methylbromide \| endo-8,8-Dimethyl-3-((1-oxo-2-propylpentyl)oxy)-8-azoniabicyclo(3.2.1)octane bromide \| Méthylbromure d'octatropine \| Methyloctatropine bromide \| Metilbromuro de octatropina \| Octatropine methylbromide \| Octatropini methylbromidum	[]	[ "Endovalpin", "Lytispasm", "Valpin" ]	[]	[ "P08912", "P11229", "P08172", "P20309" ]	[]	[]	[]
DB00518	Albendazole	A benzimidazole broad-spectrum anthelmintic structurally related to mebendazole that is effective against many diseases. (From Martindale, The Extra Pharmacopoeia, 30th ed, p38)	solid	For the treatment of parenchymal neurocysticercosis due to active lesions caused by larval forms of the pork tapeworm, <i>Taenia solium</i> and for the treatment of cystic hydatid disease of the liver, lung, and peritoneum, caused by the larval form of the dog tapeworm, <i>Echinococcus granulosus</i>.	Albendazole is a broad-spectrum anthelmintic. The principal mode of action for albendazole is by its inhibitory effect on tubulin polymerization which results in the loss of cytoplasmic microtubules.	Albendazole causes degenerative alterations in the tegument and intestinal cells of the worm by diminishing its energy production, ultimately leading to immobilization and death of the parasite. It works by binding to the colchicine-sensitive site of tubulin, thus inhibiting its polymerization or assembly into microtubules. As cytoplasmic microtubules are critical in promoting glucose uptake in larval and adult stages of the susceptible parasites, the glycogen stores of the parasites are depleted. Degenerative changes in the endoplasmic reticulum, the mitochondria of the germinal layer, and the subsequent release of lysosomes result in decreased production of adenosine triphosphate (ATP), which is the energy required for the survival of the helminth.	Poorly absorbed from the gastrointestinal tract due to its low aqueous solubility. Oral bioavailability appears to be enhanced when coadministered with a fatty meal (estimated fat content 40 g)	Hepatic. Rapidly converted in the liver to the primary metabolite, albendazole sulfoxide, which is further metabolized to albendazole sulfone and other primary oxidative metabolites that have been identified in human urine.	Symptoms of overdose include elevated liver enzymes, headaches, hair loss, low levels of white blood cells (neutropenia), fever, and itching.	Terminal elimination half-life ranges from 8 to 12 hours (single dose, 400mg).	70% bound to plasma protein	Albendazole is rapidly converted in the liver to the primary metabolite, albendazole sulfoxide, which is further metabolized to albendazole sulfone and other primary oxidative metabolites that have been identified in human urine. Urinary excretion of albendazole sulfoxide is a minor elimination pathway with less than 1% of the dose recovered in the urine. Biliary elimination presumably accounts for a portion of the elimination as evidenced by biliary concentrations of albendazole sulfoxide similar to those achieved in plasma.	null	null	Organic compounds	Organoheterocyclic compounds	Benzimidazoles	2-benzimidazolylcarbamic acid esters	[ "approved", "vet_approved" ]	[ "P02CA", "P02C", "P02", "P" ]	[ "Helminthic Microorganisms" ]	[ { "cost": "1.91", "description": "Albenza 200 mg tablet", "unit": "tablet" }, { "cost": "0.41", "description": "Albendazole powder", "unit": "g" } ]	[]	(5-(propylthio)-1H-benzimidazol-2-yl)carbamic acid methyl ester \| 5-(propylthio)-2-carbomethoxyaminobenzimidazole \| Albendazol \| Albendazole \| Albendazolum \| Eskazole \| O-methyl N-(5-(propylthio)-2-benzimidazolyl)carbamate \| Proftril \| 3.6.5.- \| Alpha-tubulin 3 \| TUBA3 \| Tubulin alpha-3 chain \| Tubulin B-alpha-1 \| TUBB2C \| Tubulin beta-2 chain \| Tubulin beta-2C chain \| 1.3.5.4 \| FL cyt \| Flavocytochrome c \| 1.14.14.1 \| CYPIA1 \| Cytochrome P450 form 6 \| Cytochrome P450-C \| Cytochrome P450-P1 \| Hydroperoxy icosatetraenoate dehydratase \| 1.14.14.1 \| Cholesterol 25-hydroxylase \| CYPIA2 \| Cytochrome P(3)450 \| Cytochrome P450 4 \| Cytochrome P450-P3 \| Hydroperoxy icosatetraenoate dehydratase \| 1,4-cineole 2-exo-monooxygenase \| 1,8-cineole 2-exo-monooxygenase \| 1.14.14.1 \| Albendazole monooxygenase (sulfoxide-forming) \| Albendazole sulfoxidase \| Cholesterol 25-hydroxylase \| CYP3A3 \| CYPIIIA3 \| CYPIIIA4 \| Cytochrome P450 3A3 \| Cytochrome P450 HLp \| Cytochrome P450 NF-25 \| Cytochrome P450-PCN1 \| Nifedipine oxidase \| Quinine 3-monooxygenase \| (R)-limonene 6-monooxygenase \| (S)-limonene 6-monooxygenase \| (S)-limonene 7-monooxygenase \| 1.14.14.1 \| CYPIIC17 \| CYPIIC19 \| Cytochrome P450-11A \| Cytochrome P450-254C \| Fenbendazole monooxygenase (4'-hydroxylating) \| Mephenytoin 4-hydroxylase \| ATP-binding cassette sub-family B member 1 \| MDR1 \| Multidrug resistance protein 1 \| P-glycoprotein 1 \| PGY1 \| Phospholipid transporter ABCB1	[ "Albendazole", "Albendazole", "Albendazole", "Albendazole", "Albendazole", "Albendazole", "Albendazole", "Albendazole", "Albendazole", "Albendazole", "Albendazole", "Albendazole", "Albendazole", "Albendazole", "Albendazole", "Albendazole", "Albendazole", "Albendazole 200 mg", "Albendazole 200 mg", "Albendazole 200 mg", "Albendazole 200 mg", "Albendazole 200 mg", "Albendazole 200 mg", "Albenza", "Albenza", "Albenza", "Albenza", "Albenza", "Albenza", "Albenza", "Albenza", "Zentel" ]	[ "Abentel", "ABZ", "Acure", "Adazol", "AL", "Band", "Bandy", "Bazole", "Ben-A", "Benrod", "Bentil", "Benzol", "Benzole", "Bevindazol", "Biwom", "Bruzol", "Buxol", "Cental", "Champs", "Ciclopar", "Cidazole", "Clearworm", "Dalben", "Despar", "Eskazole", "Valbazen", "Zolben" ]	[]	[ "Q71U36", "P68371" ]	[ "P04798", "P05177", "P08684", "P33261" ]	[]	[ "P08183" ]
DB00519	Trandolapril	Trandolapril is a non-sulhydryl prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is metabolized to its biologically active diacid form, trandolaprilat, in the liver. Trandolaprilat inhibits ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Trandolapril may be used to treat mild to moderate hypertension, to improve survival following myocardial infarction in clinically stable patients with left ventricular dysfunction, as an adjunct treatment for congestive heart failure, and to slow the rate of progression of renal disease in hypertensive individuals with diabetes mellitus and microalbuminuria or overt nephropathy.	solid	For the treatment of mild to moderate hypertension, as an adjunct in the treatment of congestive heart failure (CHF), to improve survival following myocardial infarction (MI) in individuals who are hemodynamically stable and demonstrate symptoms of left ventricular systolic dysfunction or signs of CHF within a few days following acute MI, and to slow progression of renal disease in hypertensive patients with diabetes mellitus and microalbuminuria or overt nephropathy.	Trandolapril is the ethyl ester prodrug of a nonsulfhydryl ACE inhibitor, trandolaprilat. Trandolapril is deesterified in the liver to the diacid metabolite, trandolaprilat, which is approximately eight times more active as an inhibitor of ACE than its parent compound. ACE is a peptidyl dipeptidase that is part of the RAAS. The RAAS is a homeostatic mechanism for regulating hemodynamics, water and electrolyte balance. During sympathetic stimulation or when renal blood pressure or blood flow is reduced, renin is released from the granular cells of the juxtaglomerular apparatus in the kidneys. In the blood stream, renin cleaves circulating angiotensinogen to ATI, which is subsequently cleaved to ATII by ACE. ATII increases blood pressure via a number of mechanisms. First, it stimulates the secretion of aldosterone from the adrenal cortex. Aldosterone travels to the distal convoluted tubule (DCT) and collecting tubule of nephrons where it increases sodium and water reabsorption by increasing the number of sodium channels and sodium-potassium ATPases on cell membranes. Second, ATII stimulates the secretion of vasopressin (also known as antidiuretic hormone or ADH) from the posterior pituitary gland. ADH stimulates further water reabsorption from the kidneys via insertion of aquaporin-2 channels on the apical surface of cells of the DCT and collecting tubules. Third, ATII increases blood pressure through direct arterial vasoconstriction. Stimulation of the Type 1 ATII receptor on vascular smooth muscle cells leads to a cascade of events resulting in myocyte contraction and vasoconstriction. In addition to these major effects, ATII induces the thirst response via stimulation of hypothalamic neurons. ACE inhibitors inhibit the rapid conversion of ATI to ATII and antagonize RAAS-induced increases in blood pressure. ACE (also known as kininase II) is also involved in the enzymatic deactivation of bradykinin, a vasodilator. Inhibiting the deactivation of bradykinin increases bradykinin levels and may further sustain the effects of trandolaprilat by causing increased vasodilation and decreased blood pressure. The blood pressure lowering effect of trandolaprilat is due to a decrease in peripheral vascular resistance, which is not accompanied by significant changes in urinary excretion of chloride or potassium or water or sodium retention.	There are two isoforms of ACE: the somatic isoform, which exists as a glycoprotein comprised of a single polypeptide chain of 1277; and the testicular isoform, which has a lower molecular mass and is thought to play a role in sperm maturation and binding of sperm to the oviduct epithelium. Somatic ACE has two functionally active domains, N and C, which arise from tandem gene duplication. Although the two domains have high sequence similarity, they play distinct physiological roles. The C-domain is predominantly involved in blood pressure regulation while the N-domain plays a role in hematopoietic stem cell differentiation and proliferation. ACE inhibitors bind to and inhibit the activity of both domains, but have much greater affinity for and inhibitory activity against the C-domain. Trandolaprilat, the active metabolite of trandolapril, competes with ATI for binding to ACE and inhibits and enzymatic proteolysis of ATI to ATII. Decreasing ATII levels in the body decreases blood pressure by inhibiting the pressor effects of ATII as described in the Pharmacology section above. Trandolaprilat also causes an increase in plasma renin activity likely due to a loss of feedback inhibition mediated by ATII on the release of renin and/or stimulation of reflex mechanisms via baroreceptors.	~ 40-60% absorbed; extensive first pass metabolism results in a low bioavailability of 4-14%	Cleavage of the ester group of trandolapril, primarily in the liver, is responsible for conversion to trandolaprilat, the active metabolite. Seven other metabolites, including diketopiperazine and glucuronide conjugated derivatives of trandolapril and trandolaprilat, have been identified.	Most likely clinical manifestations of overdose are symptoms of severe hypotension. Most common adverse effects include cough, headache and dizziness. The oral LD<sub>50</sub> of trandolapril in mice was 4875 mg/kg in males and 3990 mg/kg in females. In rats, an oral dose of 5000 mg/kg caused low mortality (1 male out of 5; 0 females). In dogs, an oral dose of 1000 mg/kg did not cause mortality and abnormal clinical signs were not observed.	The elimination half lives of trandolapril and trandolaprilat are about 6 and 10 hours, respectively, but, similar to all ACE inhibitors, trandolaprilat also has a prolonged terminal elimination phase that involves a small fraction of administered drug. This likely represents drug binding to plasma and tissue ACE. The effective half life of elimination for trandolaprilat is 16-24 hours.	Serum protein binding of trandolapril is ~ 80% (independent of concentration and not saturable) while that of trandolaprilat is 65 to 94% (concentration-dependent and saturable).	After oral administration of trandolapril, about 33% of parent drug and metabolites are recovered in urine, mostly as trandolaprilat, with about 66% in feces.	* 18 L	* 52 L/h [After approximately 2 mg IV doses]	Organic compounds	Organic acids and derivatives	Carboxylic acids and derivatives	Amino acids, peptides, and analogues	[ "approved" ]	[ "C09AA", "C09A", "C09", "C", "C09BB", "C09B", "C09", "C" ]	[ "Humans and other mammals" ]	[ { "cost": "1.03", "description": "Mavik 4 mg Capsule", "unit": "capsule" }, { "cost": "1.23", "description": "Trandolapril 2 mg tablet", "unit": "tablet" }, { "cost": "1.23", "description": "Trandolapril 4 mg tablet", "unit": "tablet" }, { "cost": "1.24", "description": "Trandolapril 1 mg tablet", "unit": "tablet" }, { "cost": "1.47", "description": "Mavik 1 mg tablet", "unit": "tablet" }, { "cost": "1.61", "description": "Mavik 2 mg tablet", "unit": "tablet" }, { "cost": "1.61", "description": "Mavik 4 mg tablet", "unit": "tablet" }, { "cost": "3.29", "description": "Tarka 2-180 mg Controlled Release Tabs", "unit": "tab" }, { "cost": "3.33", "description": "Tarka 1-240 mg tablet sa", "unit": "tablet" }, { "cost": "3.33", "description": "Tarka 2-180 mg tablet sa", "unit": "tablet" }, { "cost": "3.33", "description": "Tarka 2-240 mg Controlled Release Tabs", "unit": "tab" }, { "cost": "3.33", "description": "Tarka 2-240 mg tablet sa", "unit": "tablet" }, { "cost": "3.33", "description": "Tarka 4-240 mg tablet sa", "unit": "tablet" }, { "cost": "3.4", "description": "Tarka 4-240 mg Controlled Release Tabs", "unit": "tab" }, { "cost": "3.46", "description": "Tarka 1-240 mg Controlled Release Tabs", "unit": "tab" }, { "cost": "0.42", "description": "Mavik 0.5 mg Capsule", "unit": "capsule" }, { "cost": "0.72", "description": "Mavik 1 mg Capsule", "unit": "capsule" }, { "cost": "0.83", "description": "Mavik 2 mg Capsule", "unit": "capsule" } ]	[ { "approved": "1998-04-28", "country": "United States", "expires": "2015-04-28", "number": "5744496" }, { "approved": "2003-01-14", "country": "Canada", "expires": "2010-08-10", "number": "2023089" }, { "approved": "2001-03-20", "country": "Canada", "expires": "2018-03-20", "number": "1341206" } ]	Trandolapril \| Trandolaprilum \| 3.4.15.1 \| ACE \| DCP \| DCP1 \| Dipeptidyl carboxypeptidase I \| Kininase II \| ACAT \| Acyl-coenzyme A:cholesterol acyltransferase \| Brain carboxylesterase hBr1 \| Carboxylesterase 1 \| CE-1 \| CEH \| CES2 \| Cholesteryl ester hydrolase \| Cocaine carboxylesterase \| Egasyn \| hCE-1 \| HMSE \| Methylumbelliferyl-acetate deacetylase 1 \| Monocyte/macrophage serine esterase \| REH \| Retinyl ester hydrolase \| Serine esterase 1 \| SES1 \| TGH \| Triacylglycerol hydrolase \| Intestinal H(+)/peptide cotransporter \| Oligopeptide transporter, small intestine isoform \| PEPT1 \| Peptide transporter 1 \| Kidney H(+)/peptide cotransporter \| Oligopeptide transporter, kidney isoform \| PEPT2 \| Peptide transporter 2	[ "Apo-trandolapril", "Apo-trandolapril", "Apo-trandolapril", "Apo-trandolapril", "Auro-trandolapril", "Auro-trandolapril", "Auro-trandolapril", "Auro-trandolapril", "Mavik", "Mavik", "Mavik", "Mavik", "Mavik", "Mavik", "Mavik", "Mavik", "Mylan-trandolapril", "Mylan-trandolapril", "Mylan-trandolapril", "Mylan-trandolapril", "PMS-trandolapril", "PMS-trandolapril", "PMS-trandolapril", "PMS-trandolapril", "Sandoz Trandolapril", "Sandoz Trandolapril", "Sandoz Trandolapril", "Sandoz Trandolapril", "Tarka", "Tarka", "Tarka", "Tarka", "Tarka", "Tarka", "Tarka", "Tarka", "Tarka", "Tarka", "Tarka", "Teva-trandolapril", "Teva-trandolapril", "Teva-trandolapril", "Teva-trandolapril", "Trandolapril", "Trandolapril", "Trandolapril", "Trandolapril", "Trandolapril", "Trandolapril", "Trandolapril", "Trandolapril", "Trandolapril", "Trandolapril", "Trandolapril", "Trandolapril", "Trandolapril", "Trandolapril", "Trandolapril", "Trandolapril", "Trandolapril", "Trandolapril", "Trandolapril", "Trandolapril", "Trandolapril", "Trandolapril", "Trandolapril", "Trandolapril", "Trandolapril", "Trandolapril", "Trandolapril", "Trandolapril", "Trandolapril", "Trandolapril", "Trandolapril", "Trandolapril", "Trandolapril", "Trandolapril", "Trandolapril", "Trandolapril", "Trandolapril", "Trandolapril", "Trandolapril", "Trandolapril", "Trandolapril", "Trandolapril", "Trandolapril", "Trandolapril", "Trandolapril", "Trandolapril", "Trandolapril", "Trandolapril", "Trandolapril", "Trandolapril", "Trandolapril", "Trandolapril", "Trandolapril", "Trandolapril", "Trandolapril", "Trandolapril", "Trandolapril", "Trandolapril", "Trandolapril", "Trandolapril and Verapamil Hydrochloride", "Trandolapril and Verapamil Hydrochloride", "Trandolapril and Verapamil Hydrochloride", "Trandolapril and Verapamil Hydrochloride", "Trandolapril and Verapamil Hydrochloride", "Trandolapril and Verapamil Hydrochloride", "Trandolapril and Verapamil Hydrochloride", "Trandolapril and Verapamil Hydrochloride", "Trandolapril and Verapamil Hydrochloride ER", "Trandolapril and Verapamil Hydrochloride ER", "Trandolapril and Verapamil Hydrochloride ER", "Trandolapril and Verapamil Hydrochloride ER" ]	[]	[ "Tarka", "Tarka", "Tarka", "Trandolapril and Verapamil Hydrochloride", "Trandolapril and Verapamil Hydrochloride", "Trandolapril and Verapamil Hydrochloride", "Trandolapril and Verapamil Hydrochloride", "Tarka", "Tarka", "Tarka", "Tarka", "Trandolapril and Verapamil Hydrochloride", "Trandolapril and Verapamil Hydrochloride", "Trandolapril and Verapamil Hydrochloride", "Trandolapril and Verapamil Hydrochloride", "Trandolapril and Verapamil Hydrochloride ER", "Trandolapril and Verapamil Hydrochloride ER", "Trandolapril and Verapamil Hydrochloride ER", "Trandolapril and Verapamil Hydrochloride ER", "Tarka", "Tarka", "Tarka", "Tarka" ]	[ "P12821" ]	[ "P23141" ]	[]	[ "P46059", "Q16348" ]
DB00520	Caspofungin	Caspofungin (brand name Cancidas worldwide) is an antifungal drug and the first member of a new drug class called the echinocandins, as coined by Merck & Co., Inc. It is typically administered intravenously. It shows activity against infections with Aspergillus and Candida, and works by inhibiting β(1,3)-D-Glucan of the fungal cell wall.	solid	For the treatment of esophageal candidiasis and invasive aspergillosis in patients who are refractory to or intolerant of other therapies.	Caspofungin is an antifungal drug, and belongs to a new class termed the echinocandins. It is used to treat <i>Aspergillus</i> and <i>Candida</i> infection, and works by inhibiting cell wall synthesis. Antifungals in the echinocandin class inhibit the synthesis of glucan in the cell wall, probably via the enzyme 1,3-beta glucan synthase. There is a potential for resistance development to occur, however <i>in vitro</i> resistance development to Caspofungin by Aspergillus species has not been studied.	Caspofungin inhibits the synthesis of beta-(1,3)-D-glucan, an essential component of the cell wall of <i>Aspergillus</i> species and <i>Candida</i> species. beta-(1,3)-D-glucan is not present in mammalian cells. The primary target is beta-(1,3)-glucan synthase.	92% tissue distribution within 36-48 hours after intravenous infusion	Metabolized slowly by hydrolysis and N-acetylation	Side effects include rash, swelling, and nausea (rare)	9-11 hours	97%	After single intravenous administration of [3H] caspofungin acetate, excretion of caspofungin and its metabolites in humans was 35% of dose in feces and 41% of dose in urine.	null	* 12 mL/min [After single IV administration]	null	null	null	null	[ "approved" ]	[ "J02AX", "J02A", "J02", "J" ]	[ "Aspergillis, Candida and other fungi" ]	[ { "cost": "405.25", "description": "Cancidas iv 50 mg vial", "unit": "vial" }, { "cost": "421.06", "description": "Cancidas iv 70 mg vial", "unit": "vial" } ]	[ { "approved": "1995-01-03", "country": "United States", "expires": "2013-03-16", "number": "5378804" }, { "approved": "2003-06-17", "country": "Canada", "expires": "2017-04-15", "number": "2251928" }, { "approved": "2002-05-14", "country": "Canada", "expires": "2014-03-10", "number": "2118757" }, { "approved": "2000-10-24", "country": "United States", "expires": "2017-09-28", "number": "6136783" }, { "approved": "1999-09-14", "country": "United States", "expires": "2017-09-28", "number": "5952300" }, { "approved": "1996-05-07", "country": "United States", "expires": "2015-07-26", "number": "5514650" }, { "approved": "2017-05-02", "country": "United States", "expires": "2032-12-21", "number": "9636407" } ]	(4R,5S)-5-((2-Aminoethyl)amino)-N(sup 2)-(10,12-dimethyltetradecanoyl)-4-hydroxy-L-ornithyl-L-threonyl-trans-4-hydroxy-L-prolyl-(S)-4-hydroxy-4-(p-hydroxyphenyl)-L-threonyl-threo-3-hydroxy-L-ornithyl-trans-3-hydroxy-L-proline cyclic (6-1)-peptide \| Caspofungin \| Caspofungina \| 1,3-beta-D-glucan-UDP glucosyltransferase \| 2.4.1.34 \| fks1 \| 1,3-beta-D-glucan-UDP glucosyltransferase \| 2.4.1.34 \| FK506 sensitivity protein 2 \| FKS2 \| GLS2 \| Glucan synthase of cerevisiae protein 2 \| 1,4-cineole 2-exo-monooxygenase \| 1,8-cineole 2-exo-monooxygenase \| 1.14.14.1 \| Albendazole monooxygenase (sulfoxide-forming) \| Albendazole sulfoxidase \| Cholesterol 25-hydroxylase \| CYP3A3 \| CYPIIIA3 \| CYPIIIA4 \| Cytochrome P450 3A3 \| Cytochrome P450 HLp \| Cytochrome P450 NF-25 \| Cytochrome P450-PCN1 \| Nifedipine oxidase \| Quinine 3-monooxygenase \| hOCT1 \| OCT1 \| Organic cation transporter 1 \| ATP-binding cassette sub-family B member 1 \| MDR1 \| Multidrug resistance protein 1 \| P-glycoprotein 1 \| PGY1 \| Phospholipid transporter ABCB1 \| hOAT1 \| hPAHT \| hROAT1 \| OAT1 \| Organic anion transporter 1 \| PAH transporter \| PAHT \| Renal organic anion transporter 1 \| Liver-specific organic anion transporter 1 \| LST-1 \| LST1 \| OATP-2 \| OATP-C \| OATP1B1 \| OATP2 \| OATPC \| Organic anion transporter SLC21A6 \| SLC21A6 \| SLCO1B1 \| Sodium-independent organic anion-transporting polypeptide 2 \| Solute carrier family 21 member 6 \| Liver-specific organic anion transporter 2 \| LST-2 \| LST2 \| OATP-8 \| OATP1B3 \| OATP8 \| Organic anion transporter 8 \| Organic anion-transporting polypeptide 8 \| SLC21A8 \| Solute carrier family 21 member 8	[ "Cancidas", "Cancidas", "Cancidas", "Cancidas", "Cancidas", "Cancidas", "Cancidas", "Caspofungin Accord", "Caspofungin Accord", "Caspofungin Acetate", "Caspofungin Acetate", "Caspofungin Acetate", "Caspofungin Acetate", "Caspofungin Acetate", "Caspofungin Acetate", "Caspofungin acetate", "Caspofungin acetate", "Caspofungin Acetate", "Caspofungin Acetate", "Caspofungin Acetate", "Caspofungin Acetate", "Caspofungin Acetate", "Caspofungin Acetate", "Caspofungin Acetate", "Caspofungin Acetate", "Caspofungin Acetate", "Caspofungin Acetate", "Caspofungin Acetate", "Caspofungin Acetate", "Caspofungin Acetate", "Caspofungin Acetate", "Caspofungin Acetate", "Caspofungin Acetate", "Caspofungin Acetate for Injection", "Caspofungin Acetate for Injection", "Caspofungin Acetate for Injection", "Caspofungin Acetate for Injection", "Caspofungin for Injection", "Caspofungin for Injection", "Caspofungin for Injection", "Caspofungin for Injection", "Caspofungin Powder for Injection", "Caspofungin Powder for Injection" ]	[]	[]	[]	[ "P08684" ]	[]	[ "O15245", "P08183", "Q4U2R8", "Q9Y6L6", "Q9NPD5" ]
DB00521	Carteolol	A beta-adrenergic antagonist used as an anti-arrhythmia agent, an anti-angina agent, an antihypertensive agent, and an antiglaucoma agent.	solid	For the treatment of intraocular hypertension and chronic open-angle glaucoma	Carteolol is a beta1 and beta2 (non-selective) adrenergic receptor-blocking agent that does not have significant intrinsic sympathomimetic, direct myocardial depressant, or local anesthetic (membrane-stabilizing) activity. Carteolol, when applied topically to the eye, has the action of reducing elevated, as well as normal, intraocular pressure, whether or not accompanied by glaucoma. Elevated intraocular pressure is a major risk factor in the pathogenesis of glaucomatous visual field loss and optic nerve damage. Carteolol reduces intraocular pressure with little or no effect on pupil size or accommodation in contrast to the miosis which cholinergic agents are known to produce.	The primary mechanism of the ocular hypotensive action of carteolol in reducing intraocular pressure is most likely a decrease in aqueous humor production. This process is initiated by the non-selective beta1 and beta2 adrenergic receptor blockade.	null	Hepatic.	The most common effects expected with overdosage of a beta-adrenergic blocking agent are bradycardia, bronchospasm, congestive heart failure and hypotension.	null	null	null	null	null	Organic compounds	Organoheterocyclic compounds	Quinolines and derivatives	Hydroquinolines	[ "approved" ]	[ "S01ED", "S01E", "S01", "S", "S01ED", "S01E", "S01", "S", "C07AA", "C07A", "C07", "C" ]	[ "Humans and other mammals" ]	[ { "cost": "1.37", "description": "Cartrol 2.5 mg tablet", "unit": "tablet" }, { "cost": "1.37", "description": "Cartrol 5 mg tablet", "unit": "tablet" }, { "cost": "3.93", "description": "Carteolol hcl 1% eye drops", "unit": "ml" }, { "cost": "22.13", "description": "Carteolol HCl 1% Solution 5ml Bottle", "unit": "bottle" }, { "cost": "38.55", "description": "Carteolol HCl 1% Solution 10ml Bottle", "unit": "bottle" }, { "cost": "57.82", "description": "Carteolol HCl 1% Solution 15ml Bottle", "unit": "bottle" } ]	[]	Carteolol \| Cartéolol \| Carteololum \| ADRB2R \| B2AR \| Beta-2 adrenoceptor \| Beta-2 adrenoreceptor \| ADRB1R \| B1AR \| Beta-1 adrenoceptor \| Beta-1 adrenoreceptor \| 1.14.14.- \| Cholesterol 25-hydroxylase \| CYP2DL1 \| CYPIID6 \| Cytochrome P450-DB1 \| Debrisoquine 4-hydroxylase	[ "Carteolol Hydrochloride", "Carteolol Hydrochloride", "Carteolol Hydrochloride", "Ocupress" ]	[ "Endak" ]	[]	[ "P07550", "P08588" ]	[ "P10635" ]	[]	[]
DB00522	Bentiromide	Bentiromide is a dipeptide that is used in the bentiromide test, which is a screening test for evaluating pancreatic exocrine function and monitoring the adequacy of supplemental pancreatic therapy. It is typically administered orally. Cases of headache and gastrointestinal disturbances have been reported with the use of bentiromide. Bentiromide is currently not available in the U.S. or Canada.	solid	Indicated as a screening test for exocrine pancreatic insufficiency and to monitor the adequacy of supplemental pancreatic therapy.	Bentiromide is a peptide used as a screening test for exocrine pancreatic insufficiency and to monitor the adequacy of supplemental pancreatic therapy. The amount of <i>p</i>-aminobenzoic acid and its metabolites excreted in the urine is the quantitative measure of the chymotrypsin-secreting activity of the pancreas.	Bentiromide is a peptide that is broken down in the pancreas by chymotrypsin. By determining the output of unchanged bentiromide in the urine following oral administration, it is possible to determine the sufficiency of pancreatic activity.	null	Primarily hepatic. Enzymatic activity capable of hydrolyzing bentiromide has also been found in normal small intestine.	Symptoms of overdose include shortness of breath and troubled breathing.	null	null	null	null	null	Organic compounds	Organic acids and derivatives	Carboxylic acids and derivatives	Amino acids, peptides, and analogues	[ "investigational", "withdrawn" ]	[ "V04CK", "V04C", "V04", "V" ]	[ "Humans and other mammals" ]	[]	[]	Bentiromide \| Bentiromido \| Bentiromidum \| BTPABA \| PFT \| 3.4.21.106 \| TMPRSS1 \| Transmembrane protease serine 1	[]	[ "PFD" ]	[]	[ "P05981" ]	[]	[]	[]
DB00524	Metolazone	A quinazoline-sulfonamide that is considered a thiazide-like diuretic which is long-acting so useful in chronic renal failure. It also tends to lower blood pressure and increase potassium loss.	solid	For the treatment of hypertension, alone or in combination with other antihypertensive drugs of a different class.	Metolazone is a quinazoline diuretic, with properties generally similar to the thiazide diuretics. A proximal action of metolazone has been shown in humans by increased excretion of phosphate and magnesium ions and by a markedly increased fractional excretion of sodium in patients with severely compromised glomerular filtration. This action has been demonstrated in animals by micropuncture studies.	The actions of metolazone result from interference with the renal tubular mechanism of electrolyte reabsorption. Metolazone acts primarily to inhibit sodium reabsorption at the cortical diluting site and to a lesser extent in the proximal convoluted tubule. Sodium and chloride ions are excreted in approximately equivalent amounts. The increased delivery of sodium to the distal tubular exchange site results in increased potassium excretion. Metolazone does not inhibit carbonic anhydrase. The antihypertensive mechanism of action of metolazone is not fully understood but is presumed to be related to its saluretic and diuretic properties.	Peak blood levels are obtained within 2 to 4 hours of oral administration. The rate and extent of absorption are formulation dependent.	Not substantially metabolized. 70-95% is excreted unchanged in urine via glomerular filtration and active tubular secretion. Undergoes enterohepatic recycling.	Symptoms of overdose include difficulty breathing, dizziness, dizziness on standing up, drowsiness, fainting, irritation of the stomach and intestines, and lethargy leading to coma.	Approximately 14 hours.	50-70% bound to erythrocytes, up to 33% bound to plasma proteins, 2-5% of the drug in circulation is unbound	Most of the drug is excreted in the unconverted form in the urine.	null	null	Organic compounds	Organoheterocyclic compounds	Diazanaphthalenes	Benzodiazines	[ "approved" ]	[ "C03EA", "C03E", "C03", "C", "G01AE", "G01A", "G01", "G", "C03BA", "C03B", "C03", "C" ]	[ "Humans and other mammals" ]	[ { "cost": "1.37", "description": "Metolazone 2.5 mg tablet", "unit": "tablet" }, { "cost": "1.51", "description": "Metolazone 5 mg tablet", "unit": "tablet" }, { "cost": "1.74", "description": "Zaroxolyn 2.5 mg tablet", "unit": "tablet" }, { "cost": "1.8", "description": "Metolazone 10 mg tablet", "unit": "tablet" }, { "cost": "2.75", "description": "Zaroxolyn 5 mg tablet", "unit": "tablet" }, { "cost": "2.89", "description": "Zaroxolyn 10 mg tablet", "unit": "tablet" } ]	[]	2-Methyl-3-o-tolyl-6-sulfamyl-7-chloro-1,2,3,4-tetrahydro-4-quinazolinone \| 7-Chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazolinesulfonamide \| 7-Chloro-1,2,3,4-tetrahydro-2-methyl-4-oxo-3-o-tolyl-6-quinazolinesulfonamide \| Metolazon \| Metolazona \| Métolazone \| Metolazone \| Metolazonum \| Na-Cl cotransporter \| Na-Cl symporter \| NCC \| Thiazide-sensitive sodium-chloride cotransporter \| TSC	[ "Metolazone", "Metolazone", "Metolazone", "Metolazone", "Metolazone", "Metolazone", "Metolazone", "Metolazone", "Metolazone", "Metolazone", "Metolazone", "Metolazone", "Metolazone", "Metolazone", "Metolazone", "Metolazone", "Metolazone", "Metolazone", "Metolazone", "Metolazone", "Metolazone", "Metolazone", "Metolazone", "Metolazone", "Metolazone", "Metolazone", "Metolazone", "Metolazone", "Metolazone", "Metolazone", "Metolazone", "Metolazone", "Metolazone", "Metolazone", "Metolazone", "Metolazone", "Metolazone", "Metolazone", "Metolazone", "Metolazone", "Metolazone", "Metolazone", "Metolazone", "Metolazone", "Metolazone", "Metolazone", "Metolazone", "Metolazone", "Metolazone", "Metolazone", "Metolazone", "Metolazone", "Metolazone", "Metolazone", "Metolazone", "Metolazone", "Metolazone", "Metolazone", "Metolazone", "Metolazone", "Metolazone", "Metolazone", "Metolazone", "Metolazone", "Metolazone", "Metolazone", "Metolazone", "Metolazone", "Metolazone", "Metolazone", "Metolazone", "Metolazone", "Metolazone", "Metolazone", "Metolazone", "Metolazone", "Metolazone", "Metolazone", "Metolazone", "Metolazone", "Metolazone", "Metolazone", "Metolazone", "Metolazone", "Metolazone", "Metolazone", "Metolazone", "Metolazone", "Metolazone", "Mykrox Tablets", "Zaroxolyn", "Zaroxolyn", "Zaroxolyn", "Zaroxolyn", "Zaroxolyn", "Zaroxolyn", "Zaroxolyn", "Zaroxolyn Tab 10mg" ]	[ "Diulo", "Diurem", "Metadure", "Metenix", "Metolaz", "Metoral", "Metoz", "Metozone", "Mykrox", "Pavedal", "Xuret", "Zytanix" ]	[]	[ "P55017" ]	[]	[]	[]
DB00525	Tolnaftate	Tolnaftate is a synthetic over-the-counter anti-fungal agent. It may come as a cream, powder, spray, or liquid aerosol, and is used to treat jock itch, athlete's foot and ringworm. It is sold under several brand names, most notably Tinactin and Odor Eaters.	solid	Tolnaftate topical is used to treat skin infections such as athlete's foot, jock itch, and ringworm infections. Tolnaftate is also used, along with other antifungals, to treat infections of the nails, scalp, palms, and soles of the feet. The powder and powder aerosol may be used to prevent athlete's foot.	Tolnaftate is a synthetic over-the-counter anti-fungal agent.	Tolnaftate is a topical fungicide. Though its exact mechanism unknown, it is believed to prevent ergosterol biosynthesis by inhibiting squalene epoxidase. It has also been reported to distort the hyphae and to stunt mycelial growth in susceptible organisms.	null	null	Oral rat LD50: 891 mg/kg. Inhalation rat LC50: > 900 mg/m3/1hr. Irritation: skin rabbit: 500 mg/24H mild. Eye rabbit: 100 mg severe. Investigated a mutagen and reproductive effector.	null	null	null	null	null	Organic compounds	Benzenoids	Naphthalenes	null	[ "approved", "investigational", "vet_approved" ]	[ "D01AE", "D01A", "D01", "D" ]	[ "Yeast and other fungi" ]	[ { "cost": "4.77", "description": "Tolnaftate powder", "unit": "g" }, { "cost": "12.99", "description": "Zeasorb Powder 70.9 gm Can", "unit": "can" }, { "cost": "14.99", "description": "Zeasorb-AF 2% Powder 70 gm Can", "unit": "can" }, { "cost": "0.02", "description": "Pv antifungal 1% spray liquid", "unit": "g" }, { "cost": "0.03", "description": "Athlete's foot 1% liquid spray", "unit": "g" }, { "cost": "0.04", "description": "Tinactin 1% aerosol", "unit": "ml" }, { "cost": "0.05", "description": "Zeasorb powder", "unit": "g" }, { "cost": "0.19", "description": "Zeasorb-af 2% lotion", "unit": "g" } ]	[]	2-Naphthyl N-methyl-N-(3-tolyl)thionocarbamate \| m,N-Dimethylthiocarbanilic acid O-2-naphthyl ester \| Methyl (3-methylphenyl)carbamothioic acid O-2-naphthalenyl ester \| N-methyl-N-(3-methylphenyl)-1-(naphthalen-2-yloxy)methanethioamide \| O-2-Naphthyl m,N-dimethylthiocarbanilate \| Tolnaftate \| Tolnaftato \| Tolnaftatum \| Tolnaphthate \| 1.14.14.17 \| SE \| Squalene epoxidase \| 1.14.14.17 \| ERG1 \| SE \| Squalene epoxidase	[ "Absorbine Antifungal Powder 1%", "Absorbine Jr Antifungal Liq", "Absorbine Jr Antifungal Liquid", "Aftate Athlete Foot Cream", "Anti-Fungal", "Anti-Fungal", "Anti-Fungal Liquid Maximum Strength", "Antifungal", "Antifungal", "Antifungal", "Antifungal", "Antifungal", "Antifungal", "Antifungal", "Antifungal Athlete's Foot Powder Spray", "Antifungal Cream", "Antifungal Cream", "Antifungal Cream Tolnaftate 1%", "Antifungal Foot Care", "ANTIFUNGAL For Athletes Foot", "Antifungal Liquid", "AntiFungal Liquid Maximum Strength", "Antifungal Tincture", "Athlete's Foot Cream", "Athlete's Foot Gel 1%", "Athlete's Foot Spray Power", "Athletes Foot", "Athletes Foot", "Athletes Foot", "Athletes Foot", "Athletes Foot", "Athletes Foot", "Athletes Foot", "Athletes Foot", "Athletes Foot", "Athletes Foot", "Athletes Foot", "Athletes Foot Antifungal", "Athletes Foot Dr Foot", "Athletes Foot Medicated Antifungal", "Athletes Foot Quinsana", "Atopalm Tolnaftate Antifungal", "Atopalm Tolnaftate Antifungal", "Avon Foot Works Therapeutic Antifungal Foot Cream", "Avon Footworks Antifungal and Deodorant Powder", "Avon Footworks Antifungal Foot Spray", "AVON HeXashield Athletes Foot Cream", "Barielle Fungus Rx Maximum Strength Anti-Fungal", "Barielle Professional Maximum Strength Fungus Rx Antifungal PRO", "Bengama - Tolnaftate", "Bengama Antifungal", "Bio-Scriptives Extreme AF", "Blistex Odor-Eaters Powder", "Canespies", "Canespies", "Canesten Powder", "CAREALL Tolnaftate", "CIDACIN Antifungal Treatment", "CLARUS AC Antifungal Solution", "CLARUS Antifungal", "CLARUS Antifungal", "Clear 50 Nail Gel", "Clixit Airport Security Foot Wipes", "Clixit Foot Wipes 3 Pack", "Conazol antifungal", "CR-371059 Tolnaftate 1%", "CR-371059 Tolnaftate 1% Cream", "CRYSTAL FLUSH Maximum Strength Anti-Fungal Formula", "CVS Athletes Foot Cream .5oz", "Cvs Athletes Foot Tolnaftate", "CVS Health Antifungal Anthletes Foot", "CVS Health Athletes Foot", "Defense Antifungal Medicated Bar", "Defense Antifungal Medicated Bar", "Derman antifungal cream", "Derman Antifungal Powder Tolnaftate", "DermaTAF Antifungal Treatment", "DermaTAF Antifungal Treatment", "DERMATOOL Fungal Nail Solution", "Dermatool Fungal Nail Treatment", "Dg Athletes Foot", "DG Health Athletes Foot", "Dr CANUSO fungal nail eraser", "Dr CANUSO fungal nail eraser", "Dr. Canuso foot repair serum", "Dr. Gs Clear Nail", "Dr. Luke Fungal Nail Renewal", "Dr. Scholl's Athlete's Foot Powder - 1%", "Dr. Scholl's Athlete's Foot Spray Powder", "Dr. Scholls Instant Cool Athletes foot treatment with Menthol", "Dr. Scholls Instant Cool Athletes Foot Wipes", "Dr. Scholls Odor-X Foot and Sneaker", "Equaline Antifungal Cream", "Equaline Athletes Foot", "Equaline Athletes Foot", "Equaline Tolnaftate Antifungal", "Equate Athletes Foot", "equate Athletes Foot", "Equate Athletes Foot", "Equate Athletes Foot Powder", "Equate Liquid Foot", "Equate Liquid Foot", "Ez Clear", "Family Care Antifungal", "Family Care Tolnaftate", "Family Wellness Antifungal", "Family Wellness Antifungal", "Family Wellness Athletes Foot Tolnaftate 1 Cream", "First Aid Antifungal Medicated", "First Aid Antifungal Medicated", "First Aid Antifungal Medicated Cream 0.5 oz", "First Aid Antifungal Medicated Cream 1oz", "Flawless Nails", "Flexitol Medicated Anti-fungal Cream", "Flexitol Medicated Foot", "Foot Care Foam", "Foot Odor Control Powder", "Foot Odor Control Powder", "Foot Works Healthy Antifungal", "Foot Works Healthy Antifungal", "Foot Works Healthy Antifungal", "Footlogix Anti Fungal Mousse Formula", "Footrenew", "Footshield Plus", "Footworks Healthy Antifungal Powder for Athlete's Foot", "Footworks Healthy Antifungal Spray for Athlete's Foot", "Formucare Athletes Foot Maximum Strength", "Formula 3", "Formula 3", "Formula 7 - The Solution", "Formula 7 THEGEL", "Forticept Antifungal Balm", "fulton street market Athletes Foot", "FungaBlend 10", "Fungal Nail Patches", "Fungi Nail Anti-Fungal Pen", "Fungi Nail Toe and Foot", "Fungi Nail Toe and Foot", "Fungi Nail Toe and Foot", "Fungicure", "Fungicure Anti-Fungal Liquid", "Fungicure Anti-fungal Pump Spray", "Fungicure Athlete's Foot Cream", "Fungicure Athletes Foot", "Fungicure Athletes Foot", "Fungicure Gel", "FungiFoam", "Fungifoam Antifungal", "FungiFree Fungal Nail Patches", "FungiFree Nail Fungus Treatment", "Funginix AF", "Funginix Jock Itch Treatment", "Fungisolve Tolnaftate Antifungal", "Fungisolve Tolnaftate Antifungal", "Fungisolve Tolnaftate Antifungal", "Fungisolve Tolnaftate Antifungal", "Fungoid-D", "Fungus Md", "Fungus Relief", "Gadaderm Antifungal", "Gold Mountain Beauty Fungal Nail Eliminator", "Gold Mountain Beauty Intensive Repair Serum", "Good Neighbor Pharmacy Athletes foot relief", "Good Neighbor Pharmacy athletes foot relief", "Good Neighbor Pharmacy Maximum Strength Athletes Foot Relief Antifungal", "Good Sense Athletes Foot", "Good Sense Jock Itch", "GoodSense Athletes Foot Antifungal", "GoodSense Powder Jock Itch Antifungal", "HC Max Anti Fungal", "HC Max Anti-Fungal", "HC Max For Athletes Foot", "HC Max for Jock Itch", "HC Max Hongo Cura", "Healthy Accents athletes foot antifungal", "Heeltastic", "Hi Vetic", "Hi Vetic", "HomeHealth Antifungal", "Hongo Cura Maximum Strength Anti-Fungal", "Hongo Killer", "Hongo Killer", "Hongo Killer", "Hongo Killer Antifungal", "Hongosan Dsp", "Joch Itch Antifungal Quinsana", "Jock Itch", "Jock Itch", "Jock Itch Relief", "Kaiser Permanente Tolnaftate", "KERACTIL Plus", "Kerasal Athletes Foot powder", "Kerasal for Athletes Foot Silky Clear", "Kiss Fungi-Gone Anti-fungal Treatment", "Kiss Fungi-Gone Anti-fungal Treatment", "Lamisil AF Defense", "Lamisil AF Defense Shake", "Lamisl AF Defense", "Leader Antifungal Tolnaftate", "Leader Antifungal Tolnaftate", "Leader Antifungal Tolnaftate", "Leader Medicated", "Lotrimin Daily Prevention", "Lotrimin Daily Prevention Deo", "LUCKY SUPER SOFT ANTIFUNGAL For Athletes Foot", "LUCKY SUPER SOFT ANTIFUNGAL For Athletes Foot", "Luxury", "Maximum Strength Anti Fungal Liquid", "Maximum Strength Anti Fungal Tolnaftate 1%", "Maximum Strength Antifungal Liquid", "Maximum Strength Antifungal Liquid", "Maximum Strength Antifungal Liquid", "Meijer Antifungal", "Meijer Antifungal Tolnaftate Cream", "Meijer Maximum Strength Anthletes foot Antifungal", "Meijer Maximum Strength Athletes Foot Antifungal", "Meijer Maximum Strength Jock Itch Relief Antifungal", "Meijer Tolnaftate", "Micomitin Antifungal", "Miconatate", "Micotrin AL", "Miracle Plus Anti-Fungal", "Miracle Plus Anti-Fungal Foot Relief", "Miracure", "Molecular AF", "Mycozyl AL", "Mycozyl HC", "Mycozyl HC Cream Gel", "Nail Active Daytime Anti-fungal", "Nail MD", "Nail Renew", "Nail Renu", "Nailene Antifungal Treatment", "Natouch Antifungal Antiseptic Wipes", "Natouch Antifungal Wipes Plus", "Natural Fusion Anti-fungal Medi-Gel", "Natural Fusion Anti-fungal Medi-Gel", "Natureplex Tolnaftate Antifungal", "Novonail Solution", "Odor Control Tolnaftate", "Odor Eaters Foot and Sneaker", "Odor-eaters", "Ongo - Fin", "Opti-Nail 2-in-1", "Opti-Nail 2-in-1", "Personal Care Antifungal", "Phytozine Ringworm Treatment Maximum Strength", "Pitrex Crm 1%", "Premier Solutions Antifungal Tolnaftate Liquid", "Premier Solutions Antifungal Tolnaftate Powder", "Premier Value Tolnaftate Antifungal", "Proclearz Anti-fungal Pen", "Proclearz Antifungal Liquid", "ProClearz Fungi-Cide PM", "ProClearz Maximum Strength Anti-fungal Pen", "Proclearz Maximum Strength Fungal Shield Brush-ON Antifungal", "ProClearz Maximum Strength Fungal Shield Brush-on Antifungal", "Quality Choice Antifungal", "Quality Choice Tolnaftate Antifungal", "Quinsana Athletes Foot Anti Fungal", "Relispray Antifungal Liquid", "Rite Aid Athletes Foot", "Rugby Tolnaftate 1% Powder", "S-Cream TOLNAFTATE 1%", "Sanafitil", "Sanafitil Crema", "Signature Athletes Foot Antifungal", "Signature Black Bottle Tea Tree Antifungal Foot and Body Wash", "Signature Care Antifungal", "Signature Care Antifungal Cream Tolnaftate 1%", "Signature Care Athletes foot", "Signature Care Athletes Foot", "Signature Care Athletes Foot Antifungal", "Silka Antifungal", "Skinheal Antifungal", "Smart Sense Athletes Foot", "Smart Sense Athletes Foot Relief", "Smart Sense Tolnaftate Antifungal", "Smart Sense Tolnftate Antifungal", "SmartSense Maximum Strength Athletes Foot Relief antifungal", "Smooth AF", "Smooth AF", "Snap Stiks Athlete's Foot Relief Swabs With Tolnaftate", "Snap-stiks Senior's Foot Fungus Relief Swabs With Tolnaftate", "SoundBody Tolnaftate Antifungal", "Sunmark Antifungal", "Sunmark Antifungal", "Sunmark athletes foot", "Sunmark athletes foot powder", "Swabplus Athlete's Foot Relief Swabs With Tolnaftate", "Swabplus Fungus Relief Swabs With Tolnaftate", "Target antifungal", "Terbinafine HCl Chlortimazole and Tolnaftate", "Terpenicol Antifungal Solution", "Thera plus Antifungal Tolnaftate", "TheraCare Antifungal Cream", "Tinactin", "Tinactin", "Tinactin", "Tinactin", "Tinactin", "Tinactin", "Tinactin", "Tinactin", "Tinactin", "Tinactin Aerosol Powder", "Tinactin Antifungal", "Tinactin Antifungal", "Tinactin Chill Deodorant Powder Spray", "Tinactin Chill Liquid Spray", "Tinactin Jock Itch Crm 10mg/gm", "Tinactin Jock Itch Top Aer Pwr 10mg/gm", "Tinactin Liquid Aerosol 0.72mg/gm", "Tinactin Plus Areosol Powder 1%", "Tinactin Plus Powder 1%", "Tinactin Powder", "Tinactin Pump Spray", "Tinactin Sol 10mg/ml", "Tinactin Super Absorbent", "Tineacide", "Ting", "Ting", "TM -Tolnaftate", "TM-Tolnaftate LR", "Tolcylen Antifungal Cream", "Tolcylen Antifungal Solution", "Tolnafate", "Tolnafate", "Tolnafate", "Tolnafate", "Tolnafate", "Tolnafate", "Tolnafate", "Tolnafate", "Tolnafate", "Tolnafate", "Tolnafate", "Tolnafate", "Tolnafate", "Tolnafate", "Tolnafate", "Tolnafate", "Tolnafate", "Tolnafate", "Tolnafate", "Tolnafi-AL", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate", "Tolnaftate Antifungal", "Tolnaftate Antifungal", "Tolnaftate Antifungal", "Tolnaftate Antifungal", "Tolnaftate Antifungal", "Tolnaftate Antifungal", "Tolnaftate Antifungal", "Tolnaftate Antifungal Cream", "Tolnaftate Cream 1%", "Tolnaftate Cream 1% ANTIFUNGAL", "Tolnaftate Cream 1% ANTIFUNGAL", "Tolnaftate Cream 1% ANTIFUNGAL", "Tolnaftate Cream USP 1% for Athlete's Foot", "Tolnaftate Cream USP, 1%", "Tolnaftate D", "TopCare Tolnaftate Antifungal", "Up and Up Antifungal", "Up and Up Soothing Antifungal", "Villimed Antifungal", "Walgreens Athletes Foot", "Walgreens Maximum Strength Jock Itch Antifungal", "Walgreens Medicated Antifungal Athletes Foot", "Walgreens Tolnaftate", "Western Family Antifungal", "Wick Storm Tea Tree Antifungal Foot Body Wash", "Winco Antifungal", "Winco Antifungal", "Winco Foods Tolnaftate", "Woodwards Mycocide Clinical NS", "XtraCare Antifungal Foot", "XtraCare Antifungal Foot", "Zeasorb AF" ]	[ "Aftate", "Dr. Scholl's athlete's foot spray", "Genaspor", "Lamisil AF", "NP-27", "Odor Eaters", "Pitrex", "Separin", "Tinaderm" ]	[ "Nail MD", "Heeltastic", "Terbinafine HCl Chlortimazole and Tolnaftate", "Natouch Antifungal Antiseptic Wipes", "Miconatate", "Absorbine Jr Antifungal Liq", "Mycozyl HC", "Mycozyl HC Cream Gel", "FungiFree Nail Fungus Treatment" ]	[ "Q14534" ]	[]	[]	[]
DB00526	Oxaliplatin	Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Compared to cisplatin the two amine groups are replaced by diamino cyclohexane (DACH) group to provide a greater antitumor effect.[A797] However, this leads to poorer water solubility, which was compensated by the addition of the chloride moieties.[A797] Due to this chemical moiety, oxaliplatin readily undergoes non-enzymatic biotransformation, thus complicating oxaliplatin's pharmacokinetics.[A260396] Like most platinum-based compounds, oxaliplatin's mechanism of action is primarily through DNA damage through DNA crosslinking, particularly intrastrand and interstrand crosslinking.[A260396] However, due to the structure of oxaliplatin, its adducts make the binding of mismatch repair protein to DNA harder compared to cisplatin or carboplatin's adducts, resulting in greater cytotoxic effects.[A260396] The DACH moiety also prevents cross-resistance with cisplatin and carboplatin.[A797] Although oxaliplatin has been investigated as a monotherapy, it is typically administered in combination with fluorouracil and leucovorin, known as the FOLFOX regimen, for the treatment of colorectal cancer.[A796,A797] This is an effective combination treatment both as a first-line treatment and in patients refractory to an initial fluorouracil and leucovorin combination. Ongoing trials have also shown promising results for oxaliplatin use in nonHodgkin’s lymphoma, breast cancer, mesothelioma, and non-small cell lung cancer.[A797] Oxaliplatin was approved by the FDA on January 9, 2004 and is currently marketed by Sanofi-Aventis under the trademark Eloxatin®.[L47316]	solid	Oxaliplatin, in combination with infusional fluorouracil and leucovorin, is indicated for the treatment of advanced colorectal cancer and adjuvant treatment of stage III colon cancer in patients who have undergone complete resection of the primary tumor.[L47206]	In vivo studies have shown antitumor activities of oxaliplatin against colon carcinoma. In combination with fluorouracil, oxaliplatin exhibits in vitro and in vivo antiproliferative activity greater than either compound alone in several tumor models (HT29 [colon], GR [mammary], and L1210 [leukemia]).[L47206]	Oxaliplatin undergoes nonenzymatic conversion in physiologic solutions to active derivatives via displacement of the labile oxalate ligand. Several transient reactive species are formed, including monoaquo and diaquo DACH platinum, which covalently bind with macromolecules. Both inter and intrastrand Pt-DNA crosslinks are formed. Crosslinks are formed between the N7 positions of two adjacent guanines (GG), adjacent adenine-guanines (AG), and guanines separated by an intervening nucleotide (GNG). These crosslinks inhibit DNA replication and transcription. Cytotoxicity is cell-cycle nonspecific.[L47206]	The reactive oxaliplatin derivatives are present as a fraction of the unbound platinum in plasma ultrafiltrate. After a single 2-hour intravenous infusion of oxaliplatin at a dose of 85 mg/m<sup>2</sup>, pharmacokinetic parameters expressed as ultrafiltrable platinum was C<sub>max</sub> of 0.814 mcg/mL. Interpatient and intrapatient variability in ultrafiltrable platinum exposure (AUC<sub>0-48hr</sub>) assessed over 3 cycles was 23% and 6%, respectively.[L47206]	Oxaliplatin undergoes rapid and extensive nonenzymatic biotransformation. There is no evidence of cytochrome P450-mediated metabolism in vitro. Up to 17 platinum-containing derivatives have been observed in plasma ultrafiltrate samples from patients, including several cytotoxic species (monochloro DACH platinum, dichloro DACH platinum, and monoaquo and diaquo DACH platinum) and a number of noncytotoxic, conjugated species.[L47206]	The maximum dose of oxaliplatin that has been administered in a single infusion is 825 mg. Several cases of overdoses have been reported with oxaliplatin. Adverse reactions observed following an overdosage were grade 4 thrombocytopenia (less than 25,000/mm3) without bleeding, anemia, sensory neuropathy (including paresthesia, dysesthesia, laryngospasm, and facial muscle spasms), gastrointestinal disorders (including nausea, vomiting, stomatitis, flatulence, abdomen enlarged and grade 4 intestinal obstruction), grade 4 dehydration, dyspnea, wheezing, chest pain, respiratory failure, severe bradycardia, and death. Closely monitor patients suspected of receiving an overdose, including for the adverse reactions described above, and administer appropriate supportive treatment.[L47206] Based on its direct interaction with DNA, ELOXATIN can cause fetal harm when administered to a pregnant woman. The available human data do not establish the presence or absence of major birth defects or miscarriages related to the use of oxaliplatin. Reproductive toxicity studies demonstrated adverse effects on embryo-fetal development in rats at maternal doses that were below the recommended human dose based on body surface area. Advise a pregnant woman of the potential risk to a fetus.[L47206] In the adjuvant treatment trial, 400 patients who received oxaliplatin with fluorouracil/leucovorin were greater than or equal to 65 years. The effect of oxaliplatin in patients greater than or equal to 65 years was not conclusive. Patients greater than or equal to 65 years receiving ELOXATIN experienced more diarrhea and grade 3-4 neutropenia (45% vs 39%) compared to patients less than 65 years.[L47206] The AUC of unbound platinum in plasma ultrafiltrate was increased in patients with renal impairment. No dose reduction is recommended for patients with mild (creatinine clearance 50 to 79 mL/min) or moderate (creatinine clearance 30 to 49 mL/min) renal impairment, calculated by Cockcroft-Gault equation. Reduce the dose of oxaliplatin in patients with severe renal impairment (creatinine clearance less than 30 mL/min).[L47206] Long-term animal studies have not been performed to evaluate the carcinogenic potential of oxaliplatin. Oxaliplatin was not mutagenic to bacteria (Ames test) but was mutagenic to mammalian cells in vitro (L5178Y mouse lymphoma assay). Oxaliplatin was clastogenic both in vitro (chromosome aberration in human lymphocytes) and in vivo (mouse bone marrow micronucleus assay).[L47206] In a fertility study, male rats were given oxaliplatin at 0, 0.5, 1, or 2 mg/kg/day for five days every 21 days for a total of three cycles prior to mating with females that received two cycles of oxaliplatin on the same schedule. A dose of 2 mg/kg/day (less than one-seventh the recommended human dose on a body surface area basis) did not affect the pregnancy rate but resulted in 97% postimplantation loss (increased early resorptions, decreased live fetuses, decreased live births), and delayed growth (decreased fetal weight).[L47206] Testicular damage, characterized by degeneration, hypoplasia, and atrophy, was observed in dogs administered oxaliplatin at 0.75 mg/kg/day (approximately one-sixth of the recommended human dose on a body surface area basis) × 5 days every 28 days for three cycles. A no-effect level was not identified.[L47206]	The decline of ultrafilterable platinum levels following oxaliplatin administration is triphasic with two distribution phases: t1/2α; 0.43 hours and t1/2β; 16.8 hours. This is followed by a long terminal elimination phase that lasts 391 hours (t1/2γ).[L47206]	In patients, plasma protein binding of platinum is irreversible and is greater than 90%. The main binding proteins are albumin and gamma-globulins.[L47206] Platinum also binds irreversibly and accumulates (approximately 2-fold) in erythrocytes, where it appears to have no relevant activity. No platinum accumulation was observed in plasma ultrafiltrate following 85 mg/m<sup>2</sup> every two weeks.[L47206]	The major route of platinum elimination is renal excretion. At five days after a single 2-hour infusion of ELOXATIN, urinary elimination accounted for about 54% of the platinum eliminated, with fecal excretion accounting for only about 2%.[L47206]	After a single 2-hour intravenous infusion of oxaliplatin at a dose of 85 mg/m<sup>2</sup>, the volume of distribution is 440 L.At the end of a 2-hour infusion, approximately 15% of the administered platinum is present in the systemic circulation. The remaining 85% is rapidly distributed into tissues or eliminated in the urine.[L47206]	Platinum was cleared from plasma at a rate (10-17 L/h) that was similar to or exceeded the average human glomerular filtration rate (GFR; 7.5 L/h). The renal clearance of ultrafiltrable platinum is significantly correlated with GFR.[L47206]	Organic compounds	Organic nitrogen compounds	Organonitrogen compounds	Cyclohexylamines	[ "approved", "investigational" ]	[ "L01XA", "L01X", "L01", "L" ]	[ "Humans and other mammals" ]	[ { "cost": "825.0", "description": "Oxaliplatin 50 mg vial", "unit": "vial" }, { "cost": "1650.0", "description": "Oxaliplatin 100 mg vial", "unit": "vial" } ]	[ { "approved": "1994-03-01", "country": "United States", "expires": "2013-01-12", "number": "5290961" }, { "approved": "2004-06-01", "country": "Canada", "expires": "2015-08-07", "number": "2196922" }, { "approved": "1995-05-30", "country": "United States", "expires": "2017-02-09", "number": "5420319" }, { "approved": "1998-02-10", "country": "United States", "expires": "2016-02-07", "number": "5716988" } ]	(SP-4-2-(1R-TRANS))-(1,2-CYCLOHEXANEDIAMINE-N,N')(ETHANEDIOATO(2-)-O,O')PLATINUM \| Diaminocyclohexane Oxalatoplatinum \| L-OHP \| Oxalatoplatin \| Oxalatoplatinum \| Oxaliplatin \| oxaliplatine \| oxaliplatino \| oxaliplatinum \| PLATINUM, ((1R,2R)-1,2-CYCLOHEXANEDIAMINE-.KAPPA.N,.KAPPA.N')(ETHANEDIOATO(2-)-.KAPPA.O1,.KAPPA.O2)-, (SP-4-2)- \| 2.5.1.18 \| Glutathione transferase T1-1 \| GST class-theta-1 \| Metallothionein-IA \| MT-1A \| MT-IA \| MT1S \| CES1 \| Metallothionein-2A \| Metallothionein-II \| MT-2 \| MT-II \| MT2 \| 1.11.2.2 \| MPO \| 1.15.1.1 \| hSod1 \| Superoxide dismutase 1 \| 2.5.1.18 \| FAEES3 \| GST class-pi \| GST3 \| GSTP1-1 \| 2.5.1.18 \| GST class-mu 1 \| GST HB subunit 4 \| GST1 \| GSTM1-1 \| GSTM1a-1a \| GSTM1b-1b \| GTH4 \| 1.6.5.2 \| Azoreductase \| DIA4 \| DT-diaphorase \| DTD \| Menadione reductase \| NAD(P)H:quinone oxidoreductase 1 \| NMOR1 \| Phylloquinone reductase \| QR1 \| Quinone reductase 1 \| hOCT2 \| OCT2 \| Organic cation transporter 2 \| Copper transporter 1 \| COPT1 \| CTR1 \| hCTR1 \| Solute carrier family 31 member 1 \| EMT \| EMTH \| Extraneuronal monoamine transporter \| OCT3 \| Organic cation transporter 3 \| 7.6.2.2 \| ABCP \| ATP-binding cassette sub-family G member 2 \| BCRP \| BCRP1 \| Breast cancer resistance protein \| CDw338 \| Mitoxantrone resistance-associated protein \| MXR \| Placenta-specific ATP-binding cassette transporter \| Urate exporter \| 7.6.2.- \| 7.6.2.2 \| 7.6.2.3 \| Canalicular multidrug resistance protein \| Canalicular multispecific organic anion transporter 1 \| CMOAT \| CMOAT1 \| CMRP \| MRP2 \| Multidrug resistance-associated protein 2 \| 7.2.2.8 \| Copper pump 2 \| PWD \| WC1 \| Wilson disease-associated protein \| WND \| 7.2.2.8 \| Copper pump 1 \| MC1 \| Menkes disease-associated protein \| MNK	[ "Act Oxaliplatin", "Act Oxaliplatin", "Act Oxaliplatin", "Eloxatin", "Eloxatin", "Eloxatin", "Eloxatin", "Eloxatin", "Eloxatin", "Eloxatin", "Eloxatin", "Eloxatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin", "Oxaliplatin for Injection", "Oxaliplatin for Injection", "Oxaliplatin Injection", "Oxaliplatin Injection", "Oxaliplatin Injection", "Oxaliplatin Injection", "Oxaliplatin Injection", "Oxaliplatin Injection", "Oxaliplatin Injection", "Oxaliplatin Injection USP", "Oxaliplatin Injection, USP", "Oxaliplatin Injection, USP", "PMS-oxaliplatin", "Taro-oxaliplatin", "Teva-oxaliplatin Injection" ]	[]	[]	[]	[ "P30711", "P04731", "P02795", "P05164", "P00441", "P09211", "P09488", "P15559" ]	[ "P02768" ]	[ "O15244", "O15431", "O75751", "Q9UNQ0", "Q92887", "P35670", "Q04656" ]
DB00527	Cinchocaine	A local anesthetic of the amide type now generally used for surface anesthesia. It is one of the most potent and toxic of the long-acting local anesthetics and its parenteral use is restricted to spinal anesthesia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1006)	solid	For production of local or regional anesthesia by infiltration techniques such as percutaneous injection and intravenous regional anesthesia by peripheral nerve block techniques such as brachial plexus and intercostal and by central neural techniques such as lumbar and caudal epidural blocks.	Dibucaine is an amide-type local anesthetic, similar to lidocaine.	Local anesthetics block both the initiation and conduction of nerve impulses by decreasing the neuronal membrane's permeability to sodium ions through sodium channel inhibition. This reversibly stabilizes the membrane and inhibits depolarization, resulting in the failure of a propagated action potential and subsequent conduction blockade.	In general, ionized forms (salts) of local anesthetics are not readily absorbed through intact skin. However, both nonionized (bases) and ionized forms of local anesthetics are readily absorbed through traumatized or abraded skin into the systemic circulation.	Primarily hepatic.	Subcutaneous LD<sub>50</sub> in rat is 27 mg/kg. Symptoms of overdose include convulsions, hypoxia, acidosis, bradycardia, arrhythmias and cardiac arrest.	null	null	null	null	null	Organic compounds	Organoheterocyclic compounds	Quinolines and derivatives	Quinolones and derivatives	[ "approved", "vet_approved" ]	[ "D04AB", "D04A", "D04", "D", "S01HA", "S01H", "S01", "S", "S02DA", "S02D", "S02", "S", "N01BB", "N01B", "N01", "N", "C05AD", "C05A", "C05", "C" ]	[ "Humans and other mammals" ]	[ { "cost": "4.74", "description": "Dibucaine hcl powder", "unit": "g" }, { "cost": "0.12", "description": "Dibucaine 1% ointment", "unit": "g" }, { "cost": "0.15", "description": "Nupercainal 1% ointment", "unit": "g" } ]	[]	2-butoxy-N-(2-(diethylamino)ethyl)cinchoninamide \| 2-butoxy-N-(α-diethylaminoethyl)cinchoninamide \| 2-butoxy-N-(β-diethylaminoethyl)cinchoninamide \| 2-butoxy-N-[2-(diethylamino)ethyl]-4-quinolinecarboxamide \| 2-Butoxy-quinoline-4-carboxylic acid (2-diethylamino-ethyl)-amide \| 2-butoxyquinoline-4-carboxylic acid diethylaminoethylamide \| 2-N-butoxy-N-(2-diethylaminoethyl)cinchoninamide \| Cinchocaine \| Cinchocainum \| Cincocainio \| Dibucaine \| N-(2-(diethylamino)ethyl)-2-butoxycinchoninamide \| α-butyloxycinchonic acid-γ-diethylethylenediamine \| α-butyloxycinchoninic acid diethylethylenediamide \| hH1 \| Sodium channel protein cardiac muscle subunit alpha \| Sodium channel protein type V subunit alpha \| Voltage-gated sodium channel subunit alpha Nav1.5 \| hPN3 \| Peripheral nerve sodium channel 3 \| PN3 \| Sodium channel protein type X subunit alpha \| Voltage-gated sodium channel subunit alpha Nav1.8 \| CALM \| CAM \| CAM1 \| CAM2 \| CAMB \| CALML2 \| CAM3 \| CAMC \| CAMIII \| 3.1.1.8 \| Acylcholine acylhydrolase \| Butyrylcholine esterase \| CHE1 \| Choline esterase II \| Pseudocholinesterase	[ "CVS Hemorrhoidal Topical Analgesic", "Dibucaine", "Dibucaine", "Dibucaine", "Dibucaine", "Dibucaine", "Dibucaine", "Dibucaine", "Dibucaine", "Dibucaine", "Dibucaine HCl 0.5% / Lidocaine 15% / Phenylephrine HCl 1% / Prilocaine 5%", "Dibucaine Topical Anesthetic 1% Hemorrhoidal", "Nupercainal", "Nupercainal Anesthetic Ointment 1%", "Nupercainal Antiseptic Cream", "Odan Proctomyxin HC", "Odan Proctomyxin HC Suppositories", "Precaine", "Proctol Ointment", "Proctol Suppositories", "Proctosedyl", "Proctosedyl", "Proctosedyl Ointment", "Proctosedyl Ointment", "Proctosedyl Sup", "Proctosedyl Suppositories", "Proctosone Ont", "Proctosone Sup", "T.R.U.E. Test Thin-Layer Rapid Use Patch Test", "Teva-proctosone", "Teva-proctosone" ]	[ "Cincain", "Nupercaine", "Sovcaine" ]	[ "Dibucaine HCl 0.5% / Lidocaine 15% / Phenylephrine HCl 1% / Prilocaine 5%", "Precaine", "T.R.U.E. Test Thin-Layer Rapid Use Patch Test", "Proctosedyl Sup", "Proctosedyl Suppositories", "Proctosedyl Ointment", "Proctosedyl Ointment", "Proctosone Sup", "Proctosone Ont", "Proctosedyl", "Odan Proctomyxin HC", "Proctol Ointment", "Nupercainal Antiseptic Cream", "Odan Proctomyxin HC Suppositories", "Proctol Suppositories", "Proctosedyl", "Teva-proctosone", "Teva-proctosone" ]	[ "Q14524", "Q9Y5Y9", "P0DP23", "P0DP24", "P0DP25" ]	[ "P06276" ]	[]	[]
DB00528	Lercanidipine	Lercanidipine is a calcium channel blocker of the dihydropyridine class. It is sold under various commercial names including Zanidip.	solid	For the treatment of Hypertension, management of angina pectoris and Raynaud's syndrome	Lercanidipine, a dihydropyridine calcium-channel blocker, is used alone or with an angiotensin-converting enzyme inhibitor, to treat hypertension, chronic stable angina pectoris, and Prinzmetal's variant angina. Lercanidipine is similar to other peripheral vasodilators. Lercanidipine inhibits the influx of extra cellular calcium across the myocardial and vascular smooth muscle cell membranes possibly by deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum. The decrease in intracellular calcium inhibits the contractile processes of the myocardial smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload.	By deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum, Lercanidipine inhibits the influx of extracellular calcium across the myocardial and vascular smooth muscle cell membranes The decrease in intracellular calcium inhibits the contractile processes of the myocardial smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload.	null	null	null	null	null	null	null	null	Organic compounds	Benzenoids	Benzene and substituted derivatives	Diphenylmethanes	[ "approved", "investigational" ]	[ "C09DB", "C09D", "C09", "C", "C09BB", "C09B", "C09", "C", "C08CA", "C08C", "C08", "C" ]	[ "Humans and other mammals" ]	[]	[]	Lercanidipine \| Lercanidipino \| CACNLG \| Dihydropyridine-sensitive L-type, skeletal muscle calcium channel subunit gamma \| CACNL2A \| CCHL2A \| MHS3 \| Voltage-gated calcium channel subunit alpha-2/delta-1 \| 1.14.14.- \| Cholesterol 25-hydroxylase \| CYP2DL1 \| CYPIID6 \| Cytochrome P450-DB1 \| Debrisoquine 4-hydroxylase \| 1,4-cineole 2-exo-monooxygenase \| 1,8-cineole 2-exo-monooxygenase \| 1.14.14.1 \| Albendazole monooxygenase (sulfoxide-forming) \| Albendazole sulfoxidase \| Cholesterol 25-hydroxylase \| CYP3A3 \| CYPIIIA3 \| CYPIIIA4 \| Cytochrome P450 3A3 \| Cytochrome P450 HLp \| Cytochrome P450 NF-25 \| Cytochrome P450-PCN1 \| Nifedipine oxidase \| Quinine 3-monooxygenase \| 1.14.14.1 \| CYPIIIA5 \| Cytochrome P450-PCN3 \| 1.14.14.1 \| CYPIIIA7 \| Cytochrome P450-HFLA \| P450HLp2	[]	[ "Cardiovasc", "Carmen", "Corifeo", "Lercanil", "Lercaton", "Lerzam", "Renovia", "Vasodip", "Zandip", "Zanicor", "Zanidip" ]	[]	[ "Q06432", "P54289" ]	[ "P10635", "P08684", "P20815", "P24462" ]	[]	[]
DB00529	Foscarnet	An antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpes viruses and HIV.	solid	For the treatment of CMV retinitis in patients with acquired immunodeficiency syndrome (AIDS) and for treatment of acyclovir-resistant mucocutaneous HSV infections in immunocompromised patients.	Foscarnet is an organic analogue of inorganic pyrophosphate that inhibits replication of herpes viruses <i>in vitro</i> including cytomegalovirus (CMV) and herpes simplex virus types 1 and 2 (HSV-1 and HSV-2). Foscarnet does not require activation (phosphorylation) by thymidine kinase or other kinases and therefore is active in vitro against HSV TK deficient mutants and CMV UL97 mutants. Thus, HSV strains resistant to acyclovir or CMV strains resistant to ganciclovir may be sensitive to foscarnet. However, acyclovir or ganciclovir resistant mutants with alterations in the viral DNA polymerase may be resistant to foscarnet and may not respond to therapy with foscarnet. The combination of foscarnet and ganciclovir has been shown to have enhanced activity in vitro.	Foscarnet exerts its antiviral activity by a selective inhibition at the pyrophosphate binding site on virus-specific DNA polymerases at concentrations that do not affect cellular DNA polymerases.	Poorly absorbed after oral administration (bioavailability from 12 to 22%).	Not metabolized.	Oral, rat LD<sub>50</sub>: >2,000 mg/kg. Signs of overdose include renal impairment.	3.3-6.8 hours	14-17%	null	null	* 2.13 +/- 0.71 mL/min/kg [patients had normal renal function (CrCl > 80 mL/min] * 68 +/- 8 mL/min/kg [CrCl was 50-80 mL/min] * 34 +/- 9 mL/min/kg [CrCl was 25-49 mL/min] * 20 +/- 4 mL/min/kg [CrCl was 10 - 24 mL/min]	Organic compounds	Organic acids and derivatives	Organic phosphonic acids and derivatives	Organic phosphonic acids	[ "approved" ]	[ "J05AD", "J05A", "J05", "J" ]	[ "Human Herpes Virus" ]	[ { "cost": "286.3", "description": "Sodium phosphonoformate powder", "unit": "g" }, { "cost": "0.37", "description": "Foscarnet 24 mg/ml infus bttl", "unit": "ml" }, { "cost": "0.43", "description": "Foscavir 24 mg/ml infus bottle", "unit": "ml" } ]	[]	Carboxyphosphonic acid \| Foscarmet \| Phosphonoformate \| Phosphonoformic acid \| Phosphonomethanoic acid \| 2.7.7.7 \| 2.7.7.7 \| HFLF2 \| hOAT1 \| hPAHT \| hROAT1 \| OAT1 \| Organic anion transporter 1 \| PAH transporter \| PAHT \| Renal organic anion transporter 1 \| MCT 1 \| MCT1 \| Solute carrier family 16 member 1	[ "Foscarnet", "Foscarnet Sodium", "Foscarnet Sodium", "Foscarnet Sodium", "Foscarnet Sodium", "Foscarnet Sodium", "Foscarnet Sodium", "Foscarnet Sodium", "Foscavir", "Foscavir", "Foscavir UK", "Vocarvi" ]	[ "Triapten" ]	[]	[]	[]	[]	[ "Q4U2R8", "P53985" ]
DB00530	Erlotinib	Erlotinib is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase that is used in the treatment of non-small cell lung cancer, pancreatic cancer and several other types of cancer. It is typically marketed under the trade name Tarceva. Erlotinib binds to the epidermal growth factor receptor (EGFR) tyrosine kinase in a reversible fashion at the adenosine triphosphate (ATP) binding site of the receptor. Recent studies demonstrate that erlotinib is also a potent inhibitor of JAK2V617F, which is a mutant form of tyrosine kinase JAK2 found in most patients with polycythemia vera (PV) and a substantial proportion of patients with idiopathic myelofibrosis or essential thrombocythemia. This finding introduces the potential use of erlotinib in the treatment of JAK2V617F-positive PV and other myeloproliferative disorders.	solid	Erlotinib is indicated for: - The treatment of metastatic non-small cell lung cancer (NSCLC) with tumors showing epidermal growth factor receptor (EGFR) exon 19 deletions or exon 21 (L858R) substitution mutations [FDA label]. - In combination with first-line treatment for patients diagnosed with locally advanced, unresectable or metastatic pancreatic cancer [FDA label]. The safety and efficacy of erlotinib have not been established for patients with NSCLC whose tumors show other EGFR mutations. Additionally it is not recommended for use in combination with platinum-based chemotherapy. [FDA label]	null	The mechanism of clinical antitumor action of erlotinib is not fully characterized. Erlotinib inhibits the intracellular phosphorylation of tyrosine kinase associated with the epidermal growth factor receptor (EGFR). Specificity of inhibition with regard to other tyrosine kinase receptors has not been fully characterized. EGFR is expressed on the cell surface of normal cells and cancer cells.	Erlotinib is about 60% absorbed after oral administration and its bioavailability is substantially increased by food to almost 100%. Peak plasma levels occur 4 hours after dosing. The solubility of erlotinib is pH dependent. Solubility decreases pH increases. Smoking also decrease the exposure of erlotinib.	Metabolism occurs in the liver. In vitro assays of cytochrome P450 metabolism showed that erlotinib is metabolized primarily by CYP3A4 and to a lesser extent by CYP1A2, and the extrahepatic isoform CYP1A1.	Symptoms of overdose include diarrhea, rash, and liver transaminase elevation. The most common adverse reactions (>50%) in NSCLC are rash, diarrhea, anorexia and fatigue. The most common adverse reactions (>50%) in pancreatic cancer are fatigue, rash, nausea and anorexia.	Median half-life of 36.2 hours.	93% protein bound to albumin and alpha-1 acid glycoprotein (AAG)	Following a 100 mg oral dose, 91% of the dose was recovered in which 83% was in feces (1% of the dose as unchanged parent compound) and 8% in urine (0.3% of the dose as unchanged parent compound).	Apparent volume of distribution = 232 L	Smokers have a 24% higher rate of erlotinib clearance.	Organic compounds	Organoheterocyclic compounds	Diazanaphthalenes	Benzodiazines	[ "approved", "investigational" ]	[ "L01EB", "L01E", "L01", "L" ]	[ "Humans and other mammals" ]	[ { "cost": "52.78", "description": "Tarceva 25 mg tablet", "unit": "tablet" }, { "cost": "144.98", "description": "Tarceva 100 mg tablet", "unit": "tablet" }, { "cost": "163.98", "description": "Tarceva 150 mg tablet", "unit": "tablet" } ]	[ { "approved": "2010-06-22", "country": "Canada", "expires": "2024-02-11", "number": "2514977" }, { "approved": "2003-09-02", "country": "Canada", "expires": "2015-06-06", "number": "2216796" }, { "approved": "2006-08-08", "country": "United States", "expires": "2021-05-09", "number": "7087613" }, { "approved": "1998-05-05", "country": "United States", "expires": "2019-05-08", "number": "5747498" }, { "approved": "2005-05-31", "country": "United States", "expires": "2021-05-09", "number": "6900221" }, { "approved": "2009-12-29", "country": "United States", "expires": "2019-05-08", "number": "RE41065" } ]	[6,7-Bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-ethynyl-phenyl)-amine \| Erlotinib \| Orphan nuclear receptor PAR1 \| Orphan nuclear receptor PXR \| Pregnane X receptor \| PXR \| Steroid and xenobiotic receptor \| SXR \| 2.7.10.1 \| ERBB \| ERBB1 \| HER1 \| Proto-oncogene c-ErbB-1 \| Receptor tyrosine-protein kinase erbB-1 \| 1,4-cineole 2-exo-monooxygenase \| 1,8-cineole 2-exo-monooxygenase \| 1.14.14.1 \| Albendazole monooxygenase (sulfoxide-forming) \| Albendazole sulfoxidase \| Cholesterol 25-hydroxylase \| CYP3A3 \| CYPIIIA3 \| CYPIIIA4 \| Cytochrome P450 3A3 \| Cytochrome P450 HLp \| Cytochrome P450 NF-25 \| Cytochrome P450-PCN1 \| Nifedipine oxidase \| Quinine 3-monooxygenase \| 1.14.14.1 \| CYPIIIA5 \| Cytochrome P450-PCN3 \| 1.14.14.1 \| Cholesterol 25-hydroxylase \| CYPIA2 \| Cytochrome P(3)450 \| Cytochrome P450 4 \| Cytochrome P450-P3 \| Hydroperoxy icosatetraenoate dehydratase \| 1.14.14.1 \| CYPIA1 \| Cytochrome P450 form 6 \| Cytochrome P450-C \| Cytochrome P450-P1 \| Hydroperoxy icosatetraenoate dehydratase \| 1.14.14.- \| Cholesterol 25-hydroxylase \| CYP2DL1 \| CYPIID6 \| Cytochrome P450-DB1 \| Debrisoquine 4-hydroxylase \| 1.14.14.1 \| CYPIIC8 \| Cytochrome P450 form 1 \| Cytochrome P450 IIC2 \| Cytochrome P450 MP-12 \| Cytochrome P450 MP-20 \| S-mephenytoin 4-hydroxylase \| 1.14.14.1 \| CYPIB1 \| Hydroperoxy icosatetraenoate dehydratase \| 2.4.1.17 \| Bilirubin-specific UDPGT isozyme 1 \| GNT1 \| hUG-BR1 \| UDP-glucuronosyltransferase 1-1 \| UDP-glucuronosyltransferase 1A isoform 1 \| UDPGT 1-1 \| UGT1 \| UGT1-01 \| UGT1.1 \| UGT1*1 \| UGT1A1 \| 2.7.10.1 \| ERBB \| ERBB1 \| HER1 \| Proto-oncogene c-ErbB-1 \| Receptor tyrosine-protein kinase erbB-1 \| AGP 1 \| AGP1 \| OMD 1 \| Orosomucoid-1 \| 7.6.2.2 \| ABCP \| ATP-binding cassette sub-family G member 2 \| BCRP \| BCRP1 \| Breast cancer resistance protein \| CDw338 \| Mitoxantrone resistance-associated protein \| MXR \| Placenta-specific ATP-binding cassette transporter \| Urate exporter \| ATP-binding cassette sub-family B member 1 \| MDR1 \| Multidrug resistance protein 1 \| P-glycoprotein 1 \| PGY1 \| Phospholipid transporter ABCB1 \| KIAA0880 \| OATP-B \| OATP-RP2 \| OATP2B1 \| OATPB \| OATPRP2 \| Organic anion transporter B \| Organic anion transporter polypeptide-related protein 2 \| Organic anion transporting polypeptide 2B1 \| SLC21A9 \| Solute carrier family 21 member 9	[ "Apo-erlotinib", "Apo-erlotinib", "Apo-erlotinib", "Erlotinib", "Erlotinib", "Erlotinib", "Erlotinib", "Erlotinib", "Erlotinib", "Erlotinib", "Erlotinib", "Erlotinib", "Erlotinib", "Erlotinib", "Erlotinib", "Erlotinib", "Erlotinib", "Erlotinib", "Erlotinib", "Erlotinib", "Erlotinib", "Erlotinib", "Erlotinib", "Erlotinib", "Erlotinib", "Erlotinib", "Erlotinib", "Erlotinib", "Erlotinib", "Erlotinib", "Erlotinib Hydrochloride", "Erlotinib Hydrochloride", "Erlotinib Hydrochloride", "Erlotinib Hydrochloride", "Erlotinib Hydrochloride", "Erlotinib Hydrochloride", "Erlotinib Hydrochloride", "Erlotinib Hydrochloride", "Erlotinib Hydrochloride", "Erlotinib Hydrochloride", "Erlotinib Hydrochloride", "Erlotinib Hydrochloride", "Erlotinib Hydrochloride", "Erlotinib Hydrochloride", "Erlotinib Hydrochloride", "Erlotinib Hydrochloride", "Erlotinib Hydrochloride", "Erlotinib Hydrochloride", "Nat-erlotinib", "Nat-erlotinib", "Nat-erlotinib", "PMS-erlotinib", "PMS-erlotinib", "Tarceva", "Tarceva", "Tarceva", "Tarceva", "Tarceva", "Tarceva", "Tarceva", "Tarceva", "Tarceva", "Tarceva", "Tarceva", "Tarceva", "Tarceva", "Teva-erlotinib", "Teva-erlotinib", "Teva-erlotinib" ]	[]	[]	[ "O75469", "P00533" ]	[ "P08684", "P20815", "P05177", "P04798", "P10635", "P10632", "Q16678", "P22309", "P00533" ]	[ "P02768", "P02763" ]	[ "Q9UNQ0", "P08183", "O94956" ]
DB00532	Mephenytoin	Mephenytoin is used for the treatment of refractory partial epilepsy. Mephenytoin is a solid. This compound belongs to the phenylhydantoins. These are heterocyclic aromatic compounds containing an imiazolidinedione moiety substituted by a phenyl group. Mephenytoin is known to target sodium channel protein type 5 subunit alpha. Cytochrome P450 2C19, Cytochrome P450 2C8, Cytochrome P450 2C9, Cytochrome P450 2B6, Cytochrome P450 1A2, and Cytochrome P450 2D6 are known to metabolize mephenytoin. Mephenytoin is a hydantoin-derivative anticonvulsant used to control various partial seizures. Mephenytoin and oxazolidinedione derivatives are associated with higher incidences of blood dyscrasias compared to other anticonvulsants.	solid	For the treatment of refractory partial epilepsy.	Mephenytoin is an antiepileptic drug which can be useful in the treatment of epilepsy. The primary site of action appears to be the motor cortex where spread of seizure activity is inhibited. Possibly by promoting sodium efflux from neurons, mephenytoin tends to stabilize the threshold against hyperexcitability caused by excessive stimulation or environmental changes capable of reducing membrane sodium gradient. This includes the reduction of posttetanic potentiation at synapses. Loss of posttetanic potentiation prevents cortical seizure foci from detonating adjacent cortical areas. Mephenytoin reduces the maximal activity of brain stem centers responsible for the tonic phase of tonic-clonic (grand mal) seizures.	The mechanism of action of mephenytoin is not definitely known, but extensive research strongly suggests that its main mechanism is to block frequency-, use- and voltage-dependent neuronal sodium channels, and therefore limit repetitive firing of action potentials.	null	null	null	Approximately 7 hours	null	null	* 1.4 L/kg	null	Organic compounds	Organoheterocyclic compounds	Azolidines	Imidazolidines	[ "approved", "investigational", "withdrawn" ]	[ "N03AB", "N03A", "N03", "N", "N03AB", "N03A", "N03", "N" ]	[ "Humans and other mammals" ]	[]	[]	mefenitoína \| Mephenytoin \| hH1 \| Sodium channel protein cardiac muscle subunit alpha \| Sodium channel protein type V subunit alpha \| Voltage-gated sodium channel subunit alpha Nav1.5 \| Orphan nuclear receptor PAR1 \| Orphan nuclear receptor PXR \| Pregnane X receptor \| PXR \| Steroid and xenobiotic receptor \| SXR \| (R)-limonene 6-monooxygenase \| (S)-limonene 6-monooxygenase \| (S)-limonene 7-monooxygenase \| 1.14.14.1 \| CYPIIC17 \| CYPIIC19 \| Cytochrome P450-11A \| Cytochrome P450-254C \| Fenbendazole monooxygenase (4'-hydroxylating) \| Mephenytoin 4-hydroxylase \| 1,4-cineole 2-exo-monooxygenase \| 1.14.13.- \| CYPIIB6 \| Cytochrome P450 IIB1 \| 1.14.14.1 \| Cholesterol 25-hydroxylase \| CYPIA2 \| Cytochrome P(3)450 \| Cytochrome P450 4 \| Cytochrome P450-P3 \| Hydroperoxy icosatetraenoate dehydratase \| 1.14.14.- \| Cholesterol 25-hydroxylase \| CYP2DL1 \| CYPIID6 \| Cytochrome P450-DB1 \| Debrisoquine 4-hydroxylase \| 1.14.14.1 \| CYPIIC8 \| Cytochrome P450 form 1 \| Cytochrome P450 IIC2 \| Cytochrome P450 MP-12 \| Cytochrome P450 MP-20 \| S-mephenytoin 4-hydroxylase \| (R)-limonene 6-monooxygenase \| (S)-limonene 6-monooxygenase \| (S)-limonene 7-monooxygenase \| 1.14.14.1 \| Cholesterol 25-hydroxylase \| CYP2C10 \| CYPIIC9 \| Cytochrome P-450MP \| Cytochrome P450 MP-4 \| Cytochrome P450 MP-8 \| Cytochrome P450 PB-1 \| S-mephenytoin 4-hydroxylase \| Serpin A7 \| T4-binding globulin \| TBG	[ "Mesantoin" ]	[]	[]	[ "Q14524", "O75469" ]	[ "P33261", "P20813", "P05177", "P10635", "P10632", "P11712" ]	[ "P05543" ]	[]
DB00534	Chlormerodrin	Chlormerodrin is a mercurial compound with toxic side effects that was previously used as a diuretic. The radiolabeled form has been used as a diagnostic and research tool. It is no longer used and has been replaced with new classes of diuretic drugs.	solid	Previously used as a diuretic. The radiolabeled form has been used as a diagnostic and research tool.	Chlormerodrin is a mercurial compound with toxic side effects. It is no longer used and has been replaced with new classes of diuretic drugs.	Chlormerodrin most likely acts by a direct renal action. Mercurial diuresis is presumed to occur through inhibition of reabsorption of water and electrolytes in the convoluted tubules, although the problem of whether the locus of action is primarily on the proximal or distal portion has not yet been settled. There is also evidence that mercurials interfere with the permeability of the membrane of tubular cells by increasing passive influx of Na<sup>+</sup> ion, Cl<sup>-</sup> ion and water into the cells, without interfering with the active extrusion of Na<sup>+</sup> ion. Lastly, there is some evidence that chlormerodrin inhibits succinic dehydrogenase, but the clinical significance of this binding is not known.	null	null	As chlormerodrin has been shown to increase the levels of mercury in the kidney to toxic levels, any symptoms of overdose will most likely correspond to symptoms experienced in exposure to mercury.	null	null	null	null	null	Organic compounds	Organic acids and derivatives	Carboximidic acids and derivatives	Carboximidic acids	[ "approved", "withdrawn" ]	[]	[ "Humans and other mammals" ]	[]	[]	{3-[(aminocarbonyl)amino]-2-methoxypropyl}chloromercury \| 1-[3-(chloromercuri)-2-methoxypropyl]urea \| Chlormerodrin \| Chlormerodrina \| Chlormerodrine \| Chlormerodrinum \| BSC1 \| Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1 \| Kidney-specific Na-K-Cl symporter \| Na-K-2Cl cotransporter 2 \| NKCC2 \| 1.2.1.24 \| Aldehyde dehydrogenase family 5 member A1 \| NAD(+)-dependent succinic semialdehyde dehydrogenase \| SSADH	[]	[ "Mercloran", "Ormerdan" ]	[]	[ "Q13621", "P51649" ]	[]	[]	[]
DB00535	Cefdinir	Cefdinir, also known as Omnicef, is a semi-synthetic, broad-spectrum antibiotic belonging to the third generation of the cephalosporin class. It has been proven to be effective for the treatment of common bacterial infections in the ear, sinus, throat, lungs, and skin. Cefdinir was approved by the FDA in 1997 to treat a variety of mild to moderate infections and was initially marketed by Abbvie.[A180739] Because of its chemical structure, it is effective against organisms that are resistant to first-line cephalosporin therapy due to the production of beta-lactamase enzymes.[A180724,A180727]	solid	Cefdinir is indicated to treat acute bacterial otitis media, acute maxillary sinusitis, community-acquired (CA) pneumonia, acute bacterial exacerbations of chronic bronchitis, pharyngitis/tonsillitis, and uncomplicated skin and skin structure infections in children and adults.[L7330,A180739] The organisms susceptible to cefdinir have been listed below in addition to their associated clinical condition that may be treated with cefdinir.[L7330] Various beta-lactamase producing organisms may be treated, as indicated in certain sections below. Respiratory Acute bacterial exacerbations of chronic bronchitis caused by Haemophilus influenzae, Haemophilus parainfluenzae, Streptococcus pneumoniae (penicillin-susceptible only), and Moraxella catarrhalis Community-acquired pneumonia caused by Haemophilus influenzae, Haemophilus parainfluenzae, Streptococcus pneumoniae (penicillin-susceptible only), and Moraxella catarrhalis Ear, nose, and throat Acute bacterial otitis media caused by Haemophilus influenzae, Moraxella catarrhalis, and Streptococcus pneumoniae (penicillin-susceptible only) Tonsillitis caused by Streptococcus pyogenes Pharyngitis caused by Streptococcus pyogenes Acute maxillary sinusitis caused by Haemophilus pneumoniae and Streptococcus pneumoniae (penicillin-susceptible only), and Moraxella catarrhalis Skin and skin structure infections Uncomplicated skin and skin structure infections caused by Staphylococcus aureus and Streptococcus pyogenes	Cefdinir is a bactericidal agent that treats bacterial infections by interfering with cell wall synthesis.[L7330] Cefdinir exerts broad-spectrum activity against a variety of gram-positive and gram-negative bacterial infections. It is effective against several beta-lactamase enzyme producing bacteria. As a result, many organisms that are resistant to other cephalosporins may be susceptible to cefdinir.[A180727,A180733,L7351]	Five-member thiazolidine rings that make up penicillins are replaced in cephalosporins by a six-member dihydrothiazine ring, conferring greater bactericidal activity. This This 6-member ring enables cefdinir and other cephalosporins to resist inactivation by certain bacterial enzymes.[A180772] With a mechanism similar to other beta-lactam antibiotics, the bactericidal activity of cefdinir is caused by the inhibition of cell wall synthesis via binding to penicillin-binding proteins (PBPs). Cefdinir, like other cephalosporins, penetrates the bacterial cell wall, combats inactivation by beta-lactamase enzymes, and inactivates penicillin-binding proteins.[A180772] This interferes with the final step of transpeptidation in cell walls, eventually leading to cell lysis, which eventually leads to the death of bacteria that are susceptible to this drug.[A180724] Cefdinir has shown affinity to penicillin protein binding proteins 2 and 3. [A15746,A180760,A15747] It has also been shown to inhibit transpeptidase enzymes of various bacteria, which may play a role in its bactericidal action.[A180766,A180769] One in vitro study suggests that cefdinir inhibits myeloperoxidase release extracellularly.[A11897] The impact of this potential drug target in relation to its mechanism of action is unknown.	Maximal plasma cefdinir concentration can be attained between 2-4 hours after an ingested dose.[L7330] The bioavailability of cefdinir depends on the formulation used. The estimated bioavailability of cefdinir in the capsule form is approximately 16%-21%, depending on the dose. Absolute bioavailability after the administration of a suspension of cefdinir is 25%.[A180724]. The Cmax of cefdinir is 1.60 μg/mL after a 300 mg dose with an AUC of 7.05. Cmax is 2.87 μg/mL after a 600 mg dose with an AUC of 11.[L7330] A meal high in fat can reduce the absorption of cefdinir by up to 15%, however, this is not a cause for clinically significant changes, therefore cefdinir may be taken with or without food.[L7330] When given with aluminum or magnesium-containing antacids or iron, cefdinir absorption may decrease. It is recommended to allow 2 hours between cefdinir administration and the administration of these agents.[A180724]	This drug is not significantly metabolized and its pharmacological actions are mainly attributed to the parent drug.[A180724,L7330]	LD50 information Oral LD50 of cefdinir in the rat is >2000 mg/kg.[L7336] There are limited data regarding cefdinir overdose in the literature. In studies of rodents, one 5600-mg/kg dose administered orally did not lead to adverse effects. Signs of toxicity and overdose caused by other beta-lactam antibiotics included nausea, vomiting, diarrhea, abdominal pain, and seizures.[L7339]	The average plasma elimination half-life is about 1.7 hours in adults.[L7330] In children and healthy infants, plasma elimination half-life ranges from 1.2–1.5 hours.[A180724]	The plasma protein binding of cefdinir ranges from 60% to approximately 70%.[A180724,L7330]	This drug is mainly excreted by the kidneys. Dose adjustments may be required for patients with renal impairment or patients on dialysis.[L7330] Approximately 18.4% of a 300 mg dose of cefdinir was found unchanged in the urine after a 300 mg dose was administered during a pharmacokinetic study of 21 individuals.[L7354] A large proportion of the administered dose is excreted in the feces, although the majority is found in the urine.[A180772]	The average volume of distribution of cefdinir in adults is about 0.35 L/kg and 0.67 L/kg in children.[L7330,L7354] Another resource estimates the volume of distribution in adults at 1.56–2.09 L/kg.[A180724] Cefdinir is found to be distributed in various tissues at clinically effective concentrations. It may be found in the epithelial lining fluid, bronchial mucosa, tonsils, sinuses, skin blister fluid, as well as the middle ear fluid.[A180724] Third-generation cephalosporins such as cefdinir cross the blood-brain barrier and are found in high concentrations in the cerebrospinal fluid, unlike their first and second generation counterparts.[A180772] The wide tissue distribution of cefdinir allows it to treat a variety of infections throughout the body.	The renal clearance in healthy adults in a pharmacokinetic study was 2.0 (± 1.0) mL/min/kg and the clearance in patients with renal failure was lower, decreasing in proportion to the degree of renal impairment.[L7354] Dose adjustment is required in patients with renal impairment.[L7330]	Organic compounds	Organoheterocyclic compounds	Lactams	Beta lactams	[ "approved" ]	[ "J01DD", "J01D", "J01", "J" ]	[ "Humans and other mammals" ]	[ { "cost": "5.22", "description": "Cefdinir 300 mg capsule", "unit": "capsule" }, { "cost": "5.72", "description": "Omnicef 300 mg omni-pac capsule", "unit": "capsule" }, { "cost": "6.31", "description": "Omnicef 300 mg capsule", "unit": "capsule" }, { "cost": "53.05", "description": "Cefdinir 125 mg/5ml Suspension 60ml Bottle", "unit": "bottle" }, { "cost": "101.59", "description": "Omnicef 125 mg/5ml Suspension 100ml Bottle", "unit": "bottle" } ]	[ { "approved": "1990-06-19", "country": "United States", "expires": "2011-12-04", "number": "4935507" } ]	(6R,7R,Z)-7-(2-(2-aminothiazol-4-yl)-2-(hydroxyimino)acetamido)-8-oxo-3-vinyl-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid \| (6R,7R)-7-{2-(2-Amino-thiazol-4-yl)-2-[(Z)-hydroxyimino]-acetylamino}-8-oxo-3-vinyl-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid \| Cefdinir \| Cefdinirum \| CFDN \| PBP-2 \| ftsI \| Penicillin-binding protein 3 \| 1.11.2.2 \| MPO \| High-affinity sodium-dependent carnitine cotransporter \| OCTN2 \| Solute carrier family 22 member 5 \| Intestinal H(+)/peptide cotransporter \| Oligopeptide transporter, small intestine isoform \| PEPT1 \| Peptide transporter 1 \| Kidney H(+)/peptide cotransporter \| Oligopeptide transporter, kidney isoform \| PEPT2 \| Peptide transporter 2 \| hOAT1 \| hPAHT \| hROAT1 \| OAT1 \| Organic anion transporter 1 \| PAH transporter \| PAHT \| Renal organic anion transporter 1 \| hOAT3 \| OAT3 \| Organic anion/dicarboxylate exchanger \| Solute carrier family 22 member 8	[ "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Cefdinir", "Omnicef", "Omnicef", "Omnicef", "Omnicef" ]	[ "Cednir", "Cefdiel", "Cefzon", "Duocef", "Efdinir", "Idinir", "Kefnir", "Nirocef", "Oceph", "Omicef", "Omnicef R", "Palacef", "Palcef", "Rtist", "Samnir", "Xi Fu Ni", "Zefdinir", "Zinir" ]	[]	[ "P05164" ]	[]	[]	[ "O76082", "P46059", "Q16348", "Q4U2R8", "Q8TCC7" ]
DB00536	Guanidine	A strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism. It is also used in laboratory research as a protein denaturant. (From Martindale, the Extra Pharmacopoeia, 30th ed and Merck Index, 12th ed) It is also used in the treatment of myasthenia and as a fluorescent probe in HPLC.	solid	For the reduction of the symptoms of muscle weakness and easy fatigability associated with the myasthenic syndrome of Eaton-Lambert. It is not indicated for treating myasthenia gravis.	Guanidine apparently acts by enhancing the release of acetylcholine following a nerve impulse. It also appears to slow the rates of depolarization and repolarization of muscle cell membranes.	null	Rapidly absorbed and distributed	Not metabolized.	LD<sub>50</sub> = 475 mg/kg (oral, rat). Can cause severe gastrointestinal symptoms (nausea, vomiting and diarrhea), bone marrow suppression, renal insufficiency and other hematologic abnormalities (anemia, leucopenia). Severe guanidine intoxication is characterized by nervous hyperirritability, fibrillary tremors and convulsive contractions of muscle, salivation, vomiting, diarrhea, hypoglycemia, and circulatory disturbances.	7-8 hours	null	null	null	null	Organic compounds	Organic nitrogen compounds	Organonitrogen compounds	Guanidines	[ "approved" ]	[]	[ "Humans and other mammals" ]	[ { "cost": "0.25", "description": "Guanidine hcl 125 mg tablet", "unit": "tablet" } ]	[]	Aminomethanamidine \| Gu \| Guanidin \| Guanidine \| Imidourea \| Iminourea \| 1.2.1.3 \| ALDH class 2 \| ALDH-E2 \| ALDHI \| ALDM \| 4.6.1.18 \| HP-RNase \| RIB-1 \| RIB1 \| Ribonuclease 1 \| Ribonuclease A \| RNase 1 \| RNase A \| RNase UpI-1 \| RNS1 \| Postsynaptic density protein 95 \| PSD-95 \| PSD95 \| SAP-90 \| SAP90 \| Synapse-associated protein 90 \| 3.2.1.17 \| Lysis protein \| Lysozyme \| Muramidase \| 2.1.1.2 \| 3.5.3.1 \| hOCT2 \| OCT2 \| Organic cation transporter 2 \| hOCT1 \| OCT1 \| Organic cation transporter 1 \| EMT \| EMTH \| Extraneuronal monoamine transporter \| OCT3 \| Organic cation transporter 3 \| High-affinity sodium-dependent carnitine cotransporter \| OCTN2 \| Solute carrier family 22 member 5 \| hOAT3 \| OAT3 \| Organic anion/dicarboxylate exchanger \| Solute carrier family 22 member 8 \| Ergothioneine transporter \| ET transporter \| ETT \| ETTh \| OCTN1 \| Organic cation/carnitine transporter 1 \| UT2H \| hMATE-1 \| MATE-1 \| MATE1 \| Solute carrier family 47 member 1 \| hMATE-2 \| Kidney-specific H(+)/organic cation antiporter \| MATE-2 \| MATE2 \| Solute carrier family 47 member 2	[ "Guanidine hydrochloride" ]	[]	[]	[ "P05091", "P07998", "P78352", "Q14353" ]	[]	[]	[ "O15244", "O15245", "O75751", "O76082", "Q8TCC7", "Q9H015", "Q96FL8", "Q86VL8" ]
DB00537	Ciprofloxacin	Ciprofloxacin is a second generation fluoroquinolone that has spawned many derivative antibiotics.[A178870] It is formulated for oral, intravenous, intratympanic, ophthalmic, and otic administration for a number of bacterial infections.[L6469,L6472,L6475,L6478,L6481,L6484,L6487,L6490,L6493] The first ciprofloxacin containing product was FDA approved on 22 October 1987.[L6463]	solid	Ciprofloxacin is only indicated in infections caused by susceptible bacteria.[L6469,L6472,L6475,L6478,L6481,L6484,L6487,L6490,L6493] Ciprofloxacin immediate release tablets, oral suspensions, and intravenous injections are indicated for the treatment of skin and skin structure infections, bone and joint infections, complicated intra-abdominal infections, nosocomial pneumonia, febrile neutropenia, adults who have inhaled anthrax, plague, chronic bacterial prostatitis, lower respiratory tract infections including acute exacerbations of chronic bronchitis, urinary tract infections, complicated urinary tract infections in pediatrics, complicated pyelonephritis in pediatrics, and acute sinusitis.[L6481,L6478] A ciprofloxacin otic solution and otic suspension with hydrocortisone are indicated for acute otitis externa.[L6469,L6484] Ciprofloxacin suspension with dexamethasone is indicated for acute otitis media in pediatric patients with tympanostomy tubes or acute otitis externa.[L6490] A ciprofloxacin intratympanic injection is indicated for pediatric patients with bilateral otitis media with effusion who are having tympanostomy tubes placed or pediatric patients 6 months or older with acute otitis externa.[L6493] A ciprofloxacin eye drop is indicated for bacterial corneal ulcers and conjunctivitis.[L6472] A ciprofloxacin eye ointment is indicated for bacterial conjunctivitis.[L6475] A ciprofloxacin extended release tablet is indicated for uncomplicated urinary tract infections, complicated urinary tract infections, and acute uncomplicated pyelonephritis.[L6487]	Ciprofloxacin is a second generation fluoroquinolone that is active against many Gram negative and Gram positive bacteria.[A178870,L6469,L6472,L6475,L6478,L6481,L6484,L6487,L6490,L6493] It produces its action through inhibition of bacterial DNA gyrase and topoisomerase IV.[A178885] Ciprofloxacin binds to bacterial DNA gyrase with 100 times the affinity of mammalian DNA gyrase.[A178894] There is no cross resistance between fluoroquinolones and other classes of antibiotics, so it may be of clinical value when other antibiotics are no longer effective.[A178894] Ciprofloxain and its derivatives are also being investigated for its action against malaria, cancers, and AIDS.[A178885]	Ciprofloxacin acts on bacterial topoisomerase II (DNA gyrase) and topoisomerase IV.[A178885] Ciprofloxacin's targeting of the alpha subunits of DNA gyrase prevents it from supercoiling the bacterial DNA which prevents DNA replication.[A178876,A178882]	A 250mg oral dose of ciprofloxacin reaches an average maximum concentration of 0.94mg/L in 0.81 hours with an average area under the curve of 1.013L/h\*kg.[A178858] The FDA reports an oral bioavailability of 70-80%[Label,A820] while other studies report it to be approximately 60%.[A178858] An early review of ciprofloxacin reported an oral bioavailability of 64-85% but recommends 70% for all practical uses.[A178876]	Ciprofloxacin is primarily metabolized by CYP1A2.[L6481] The primary metabolites oxociprofloxacin and sulociprofloxacin make up 3-8% of the total dose each.[L6487] Ciprofloxacin is also converted to the minor metabolites desethylene ciprofloxacin and formylciprofloxacin.[L6487] These 4 metabolites account for 15% of a total oral dose.[L6481] There is a lack of available data on the enzymes and types of reactions involved in forming these metabolites.[A178822,A178819,A178828,A178831]	Patients experiencing an overdose may present with nausea, vomiting, abdominal pain, crystalluria, nephrotoxicity, and oliguria.[A178954,A178957,A178960] Ciprofloxacin overdose typically leads to acute renal failure.[A178960] An overdose may progress over the next 6 days with rising serum creatinine and BUN, as well as anuria.[A178957] Patients may require prednisone therapy, urgent hemodialysis, or supportive therapy.[A178954,A178960] Depending on the degree of overdose, patients may recover normal kidney function or progress to chronic kidney failure.[A178960] The oral LD50 in rats is >2000mg/kg.[L6529] Ciprofloxacin for intratympanic injection or otic use has low systemic absorption and so it unlikely to be a risk in pregnancy or lactation.[L6493] There is generally no harm to the fetus in animal studies, however high doses may lead to gastrointestinal disturbances in the mother which may increase the incidence of abortion.[L6490,L6472,L6484,L6475] In human studies there was no increase in fetal malformations above background rates.[L6478,L6481] The risk and benefit of ciprofloxacin should be weighed in pregnancy and breast feeding.[L6490,L6472,L6484,L6478,L6481,L6487,L6475,L6469] 2/8 in vitro tests and 0/3 in vivo tests of mutagenicity of ciprofloxacin have yielded a positive result.[L6493,L6490,L6472,L6484,L6478,L6481,L6487,L6475,L6469] Oral doses of 200 and 300 times the maximum recommended clinical dose in rats and mice have shown no carcinogenicity or tumorigenicity.[L6493,L6472,L6484,L6478,L6481,L6487,L6475,L6469] Oral doses above the maximum recommended clinical dose have shown no effects on fertility in rats.[L6493,L6484,L6478,L6481,L6487,L6475,L6469]	The average half life following a 250mg oral dose was 4.71 hours and 3.65 hours following a 100mg intravenous dose.[A178858] Generally the half life is reported as 4 hours.[Label,A178858]	20-40%.[Label,A178876]	27% of an oral dose was recovered unmetabolized in urine compared to 46% of an intravenous dose.[A178858] Collection of radiolabelled ciprofloxacin resulted in 45% recovery in urine and 62% recovery in feces.[A178876]	Cirpofloxacin follws a 3 compartment distribution model with a central compartment volume of 0.161L/kg[A178858] and a total volume of distribution of 2.00-3.04L/kg.[A178876]	The average renal clearance after a 250mg oral dose is 5.08mL/min\kg.[A178858] Following a 100mg intravenous dose, the average total clearance is 9.62mL/min\kg, average renal clearance is 4.42mL/min\kg, and average non renal clearance is 5.21mL/min\kg.[A178858]	Organic compounds	Organoheterocyclic compounds	Quinolines and derivatives	Quinoline carboxylic acids	[ "approved", "investigational" ]	[ "J01RA", "J01R", "J01", "J", "S03AA", "S03A", "S03", "S", "J01MA", "J01M", "J01", "J", "S02AA", "S02A", "S02", "S", "J01RA", "J01R", "J01", "J", "J01RA", "J01R", "J01", "J", "S01AE", "S01A", "S01", "S" ]	[ "Enteric bacteria and other eubacteria" ]	[ { "cost": "1.18", "description": "Apo-Ciproflox 0.3 % Solution", "unit": "ml" }, { "cost": "1.18", "description": "Pms-Ciprofloxacin 0.3 % Solution", "unit": "ml" }, { "cost": "1.29", "description": "Ciprofloxacin hcl powder", "unit": "g" }, { "cost": "2.18", "description": "Ciloxan 0.3 % Solution", "unit": "ml" }, { "cost": "4.17", "description": "Ciprofloxacin hcl 100 mg tablet", "unit": "tablet" }, { "cost": "4.28", "description": "Floxin otic singles", "unit": "each" }, { "cost": "4.59", "description": "Ciprofloxacin hcl 250 mg tablet", "unit": "tablet" }, { "cost": "5.2", "description": "Cipro 250 mg tablet", "unit": "tablet" }, { "cost": "5.59", "description": "Ciprofloxacin hcl 500 mg tablet", "unit": "tablet" }, { "cost": "5.61", "description": "Floxin 300 mg tablet", "unit": "tablet" }, { "cost": "5.65", "description": "Ciprofloxacin hcl 750 mg tablet", "unit": "tablet" }, { "cost": "6.08", "description": "Cipro 500 mg tablet", "unit": "tablet" }, { "cost": "6.26", "description": "Cipro 750 mg tablet", "unit": "tablet" }, { "cost": "6.6", "description": "Floxin 200 mg tablet", "unit": "tablet" }, { "cost": "7.14", "description": "Cetraxal 0.2% ear solution", "unit": "each" }, { "cost": "9.55", "description": "Floxin 400 mg tablet", "unit": "tablet" }, { "cost": "9.8", "description": "Ciprofloxacin er 500 mg tablet", "unit": "tablet" }, { "cost": "10.19", "description": "Ciprofloxacin-Ciproflox HCl 500 mg 24 Hour tablet", "unit": "tablet" }, { "cost": "10.46", "description": "Cipro xr 500 mg tablet", "unit": "tablet" }, { "cost": "10.75", "description": "Cipro XR 1000 mg 24 Hour tablet", "unit": "tablet" }, { "cost": "10.88", "description": "Cipro XR 500 mg 24 Hour tablet", "unit": "tablet" }, { "cost": "11.16", "description": "Ciprofloxacin er 1000 mg tablet", "unit": "tablet" }, { "cost": "11.18", "description": "ProQuin XR 500 mg 24 Hour tablet", "unit": "tablet" }, { "cost": "11.35", "description": "Ocuflox 0.3% eye drops", "unit": "ml" }, { "cost": "11.6", "description": "Ciprofloxacin-Ciproflox HCl 1000 mg 24 Hour tablet", "unit": "tablet" }, { "cost": "11.91", "description": "Cipro xr 1000 mg tablet", "unit": "tablet" }, { "cost": "12.18", "description": "Proquin xr 500 mg tablet", "unit": "tablet" }, { "cost": "12.65", "description": "Cipro hc otic suspension", "unit": "ml" }, { "cost": "12.96", "description": "Ciprofloxacin 0.3% eye drop", "unit": "ml" }, { "cost": "13.33", "description": "Ciloxan 0.3% eye drops", "unit": "ml" }, { "cost": "26.03", "description": "Ciprofloxacin HCl 0.3% Solution 2.5ml Bottle", "unit": "bottle" }, { "cost": "39.99", "description": "ProQuin XR 3 500 mg 24 Hour tablet Disp Pack", "unit": "disp" }, { "cost": "49.2", "description": "Ciprofloxacin HCl 0.3% Solution 5ml Bottle", "unit": "bottle" }, { "cost": "57.32", "description": "Ocuflox 0.3% Solution 5ml Bottle", "unit": "bottle" }, { "cost": "68.33", "description": "Ciloxan 0.3% Solution 5ml Bottle", "unit": "bottle" }, { "cost": "86.49", "description": "Floxin Otic 0.3% Solution 5ml Bottle", "unit": "bottle" }, { "cost": "87.49", "description": "Ciloxan 0.3% Ointment 3.5 gm Tube", "unit": "tube" }, { "cost": "98.22", "description": "Ciprofloxacin HCl 0.3% Solution 10ml Bottle", "unit": "bottle" }, { "cost": "106.09", "description": "Ocuflox 0.3% Solution 10ml Bottle", "unit": "bottle" }, { "cost": "116.8", "description": "Cipro 250 mg/5ml(5%) Suspension 100ml Bottle", "unit": "bottle" }, { "cost": "131.54", "description": "Cipro HC 0.2-1% Suspension 10ml Bottle", "unit": "bottle" }, { "cost": "136.75", "description": "Cipro 500 mg/5ml(10%) Suspension 100ml Bottle", "unit": "bottle" }, { "cost": "142.91", "description": "Floxin Otic 0.3% Solution 10ml Bottle", "unit": "bottle" }, { "cost": "259.99", "description": "Cipro 400 mg Solution 40ml Vial", "unit": "vial" }, { "cost": "0.03", "description": "Ciprofloxacn-d5w 200 mg/100 ml", "unit": "ml" }, { "cost": "0.13", "description": "Ciprofloxacin 200 mg/20 ml vial", "unit": "ml" }, { "cost": "0.16", "description": "Cipro i.v. 200 mg/100 ml d5w", "unit": "ml" }, { "cost": "0.72", "description": "Cipro i.v. 10 mg/ml vial", "unit": "ml" } ]	[ { "approved": "1994-02-15", "country": "United States", "expires": "2011-02-15", "number": "5286754" }, { "approved": "2005-09-27", "country": "Canada", "expires": "2021-06-13", "number": "2414271" }, { "approved": "1994-07-26", "country": "Canada", "expires": "2011-07-26", "number": "1330946" }, { "approved": "2012-05-29", "country": "United States", "expires": "2021-12-23", "number": "8187632" }, { "approved": "2010-05-04", "country": "United States", "expires": "2021-12-23", "number": "7709022" }, { "approved": "2014-09-30", "country": "United States", "expires": "2025-06-04", "number": "8846650" }, { "approved": "2015-10-06", "country": "United States", "expires": "2022-09-13", "number": "9149486" }, { "approved": "2002-03-19", "country": "United States", "expires": "2020-08-10", "number": "6359016" }, { "approved": "2001-09-04", "country": "United States", "expires": "2020-08-10", "number": "6284804" }, { "approved": "1999-10-26", "country": "United States", "expires": "2016-09-19", "number": "5972389" }, { "approved": "2002-01-22", "country": "United States", "expires": "2016-09-19", "number": "6340475" }, { "approved": "2003-10-21", "country": "United States", "expires": "2016-09-19", "number": "6635280" }, { "approved": "2002-12-03", "country": "United States", "expires": "2020-06-20", "number": "6488962" }, { "approved": "2015-12-08", "country": "United States", "expires": "2029-04-21", "number": "9205048" }, { "approved": "2012-11-27", "country": "United States", "expires": "2030-04-27", "number": "8318817" }, { "approved": "2015-12-29", "country": "United States", "expires": "2035-07-01", "number": "9220796" }, { "approved": "2016-01-12", "country": "United States", "expires": "2029-12-11", "number": "9233068" }, { "approved": "2015-01-13", "country": "United States", "expires": "2030-03-24", "number": "8932610" }, { "approved": "2016-05-24", "country": "United States", "expires": "2022-09-13", "number": "9345714" }, { "approved": "2016-08-02", "country": "United States", "expires": "2022-09-13", "number": "9402805" }, { "approved": "2017-03-28", "country": "United States", "expires": "2029-04-21", "number": "9603796" }, { "approved": "2021-06-22", "country": "United States", "expires": "2037-11-12", "number": "11040004" }, { "approved": "2018-11-27", "country": "United States", "expires": "2038-11-27", "number": "11246863" }, { "approved": "2009-04-21", "country": "United States", "expires": "2029-04-21", "number": "11369566" } ]	1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid \| 1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid \| 1-Cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydro-quinoline-3-carboxylic acid \| 1-cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid \| 1-Cyclopropyl-6-fluoro-7-(4-methyl-piperazin-1-yl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid \| 1-cyclopropyl-6-fluoro-7-hexahydro-1-pyrazinyl-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid \| Ciprofloxacin \| Ciprofloxacine \| Ciprofloxacino \| Ciprofloxacinum \| 5.99.1.3 \| Topoisomerase IV subunit A \| 5.99.1.3 \| 2.1.1.45 \| CDC21 \| TS \| TSA1 \| 5.99.1.3 \| 5.99.1.3 \| 5.6.2.2 \| DNA topoisomerase II, alpha isozyme \| TOP2 \| Eag homolog \| Eag-related protein 1 \| ERG \| ERG-1 \| ERG1 \| Ether-a-go-go-related gene potassium channel 1 \| Ether-a-go-go-related protein 1 \| H-ERG \| HERG \| hERG-1 \| hERG1 \| Potassium voltage-gated channel subfamily H member 2 \| Voltage-gated potassium channel subunit Kv11.1 \| 5.99.1.3 \| hisW \| nalA \| parD \| 5.99.1.3 \| grlA \| Topoisomerase IV subunit A \| 5.99.1.3 \| grlB \| Topoisomerase IV subunit B \| 5.99.1.3 \| cafB \| nalA \| Multidrug-efflux transporter \| 1.14.14.1 \| Cholesterol 25-hydroxylase \| CYPIA2 \| Cytochrome P(3)450 \| Cytochrome P450 4 \| Cytochrome P450-P3 \| Hydroperoxy icosatetraenoate dehydratase \| 1,4-cineole 2-exo-monooxygenase \| 1,8-cineole 2-exo-monooxygenase \| 1.14.14.1 \| Albendazole monooxygenase (sulfoxide-forming) \| Albendazole sulfoxidase \| Cholesterol 25-hydroxylase \| CYP3A3 \| CYPIIIA3 \| CYPIIIA4 \| Cytochrome P450 3A3 \| Cytochrome P450 HLp \| Cytochrome P450 NF-25 \| Cytochrome P450-PCN1 \| Nifedipine oxidase \| Quinine 3-monooxygenase \| 1.14.14.1 \| CYPIIIA5 \| Cytochrome P450-PCN3 \| 1.14.14.1 \| CYPIIIA7 \| Cytochrome P450-HFLA \| P450HLp2 \| ATP-binding cassette sub-family B member 1 \| MDR1 \| Multidrug resistance protein 1 \| P-glycoprotein 1 \| PGY1 \| Phospholipid transporter ABCB1 \| hMATE-1 \| MATE-1 \| MATE1 \| Solute carrier family 47 member 1 \| hMATE-2 \| Kidney-specific H(+)/organic cation antiporter \| MATE-2 \| MATE2 \| Solute carrier family 47 member 2	[ "Act Ciprofloxacin", "Act Ciprofloxacin", "Act Ciprofloxacin", "Ag-ciprofloxacin", "Ag-ciprofloxacin", "Ag-ciprofloxacin", "Apo-ciproflox", "Apo-ciproflox", "Apo-ciproflox", "Apo-ciproflox", "Apo-ciproflox", "Auro-ciprofloxacin", "Auro-ciprofloxacin", "Auro-ciprofloxacin", "Bio-ciprofloxacin", "Cetraxal", "Ciloxan", "Ciloxan", "Ciloxan", "Ciloxan", "Ciloxan", "Ciloxan", "Ciloxan", "Cipro", "Cipro", "Cipro", "Cipro", "Cipro", "Cipro", "Cipro", "Cipro", "Cipro", "Cipro", "Cipro", "Cipro", "Cipro", "Cipro", "Cipro", "Cipro", "Cipro", "Cipro", "Cipro", "Cipro", "Cipro", "Cipro", "Cipro", "Cipro", "Cipro", "Cipro", "Cipro", "Cipro", "Cipro", "Cipro", "Cipro", "Cipro 100 - Tab 100mg", "Cipro HC", "Cipro HC", "Cipro HC", "Cipro HC", "Cipro HC", "Cipro HC", "Cipro HC", "Cipro HC", "Cipro HC Otic Suspension", "Cipro I.V. - Liq 10mg/ml", "Cipro I.V. Minibags 2mg/ml", "Cipro IV 10mg/ml", "Cipro Oral Suspension", "Cipro Tab 100mg", "Cipro Tab 250mg", "Cipro Tab 500mg", "Cipro Tab 750mg", "Cipro XL", "Cipro XL", "Cipro XR", "Cipro XR", "Cipro XR", "Cipro XR", "Ciprodex", "Ciprodex", "Ciprodex", "Ciprodex", "Ciprodex", "Ciprodex", "Ciprodex", "Ciprodex", "Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin", 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"Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin and Dexamethasone", "Ciprofloxacin and Dexamethasone", "Ciprofloxacin and Dexamethasone", "Ciprofloxacin and Dexamethasone", "Ciprofloxacin and dexamethasone", "Ciprofloxacin and dexamethasone", "Ciprofloxacin and Dexamethasone", "Ciprofloxacin and Dexamethasone", "Ciprofloxacin and dexamethasone", "Ciprofloxacin and Dexamethasone", "Ciprofloxacin and Dextrose", "Ciprofloxacin and Dextrose", "Ciprofloxacin and Dextrose", "Ciprofloxacin and Fluocinolone Acetonide", "Ciprofloxacin and Fluocinolone Acetonide", "Ciprofloxacin HCL", "Ciprofloxacin HCL", "Ciprofloxacin HCl Ophthalmic", "Ciprofloxacin hydrochloride", "Ciprofloxacin Hydrochloride", "Ciprofloxacin Hydrochloride", "Ciprofloxacin hydrochloride", "Ciprofloxacin Hydrochloride", "Ciprofloxacin Hydrochloride", "Ciprofloxacin Hydrochloride", "Ciprofloxacin Hydrochloride", "Ciprofloxacin Hydrochloride", "Ciprofloxacin Hydrochloride", "Ciprofloxacin Hydrochloride", "Ciprofloxacin Hydrochloride", "Ciprofloxacin Hydrochloride", "Ciprofloxacin Hydrochloride", "Ciprofloxacin Hydrochloride", "Ciprofloxacin Hydrochloride", "Ciprofloxacin Hydrochloride", "Ciprofloxacin Hydrochloride", "Ciprofloxacin Hydrochloride", "Ciprofloxacin hydrochloride", "Ciprofloxacin hydrochloride", "Ciprofloxacin hydrochloride", "Ciprofloxacin Hydrochloride", "Ciprofloxacin Hydrochloride", "Ciprofloxacin Hydrochloride", "Ciprofloxacin hydrochloride", "Ciprofloxacin Hydrochloride", "Ciprofloxacin Hydrochloride", "Ciprofloxacin Hydrochloride", "Ciprofloxacin Hydrochloride", "Ciprofloxacin Hydrochloride", "Ciprofloxacin Hydrochloride", "Ciprofloxacin Hydrochloride", "Ciprofloxacin Hydrochloride", "Ciprofloxacin Hydrochloride", "Ciprofloxacin hydrochloride", "Ciprofloxacin Hydrochloride", "Ciprofloxacin Hydrochloride", "Ciprofloxacin Hydrochloride", "Ciprofloxacin Hydrochloride", "Ciprofloxacin Hydrochloride", "Ciprofloxacin Hydrochloride", "Ciprofloxacin Hydrochloride", "Ciprofloxacin in Dextrose", "Ciprofloxacin in Dextrose", "Ciprofloxacin Injection", "Ciprofloxacin Injection", "Ciprofloxacin Injection", "Ciprofloxacin Injection", "Ciprofloxacin Injection", "Ciprofloxacin Injection USP", "Ciprofloxacin Injection USP", "Ciprofloxacin Injection, USP", "Ciprofloxacin Intravenous Infusion", "Ciprofloxacin Intravenous Infusion BP", "Ciprofloxacin Intravenous Infusion, BP", "Ciprofloxacin Omega", "Ciprofloxacin Otic", "Ciprofloxacin Otic Solution, 0.2%", "Ciprofloxacin Tablets", "Ciprofloxacin Tablets", "Ciprofloxacin Tablets", "Ciprofloxacin Tablets USP", "Ciprofloxacin Tablets USP", "Ciprofloxacin Tablets USP", "Ciprofloxacin Tablets USP", "Ciprofloxacin-250", "Ciprofloxacin-500", "Ciprofloxacin-750", "Dom-ciprofloxacin", "Dom-ciprofloxacin", "Dom-ciprofloxacin", "Dom-ciprofloxacin", "Ipg-ciprofloxacin", "Ipg-ciprofloxacin", "Ipg-ciprofloxacin", "Jamp-ciprofloxacin", "Jamp-ciprofloxacin", "Jamp-ciprofloxacin", "Mar-ciprofloxacin", "Mar-ciprofloxacin", "Mar-ciprofloxacin", "Mint-ciproflox", "Mint-ciproflox", "Mint-ciproflox", "Mint-ciprofloxacin", "Mint-ciprofloxacin", "Mint-ciprofloxacin", "Mylan-ciprofloxacin", "Mylan-ciprofloxacin", "Mylan-ciprofloxacin", "Mylan-ciprofloxacin XL", "Mylan-ciprofloxacin XL", "Nra-ciprofloxacin", "Nra-ciprofloxacin", "Nra-ciprofloxacin", "Nu-ciproflox", "Nu-ciprofloxacin Tablets", "Nu-ciprofloxacin Tablets", "Nu-ciprofloxacin Tablets", "Nu-ciprofloxacin Tablets", "Otiprio", "Otiprio", "Otiprio", "Otixal", "Otovel", "Otovel", "PHL-ciprofloxacin", "PHL-ciprofloxacin", "PHL-ciprofloxacin", "PHL-ciprofloxacin", "PMS-ciprofloxacin", "PMS-ciprofloxacin", "PMS-ciprofloxacin", "PMS-ciprofloxacin", "PMS-ciprofloxacin 0.3%", "PMS-ciprofloxacin XL", "Priva-ciprofloxacin", "Pro-ciprofloxacin", "Pro-ciprofloxacin", "ProQuin XR", "Proquin XR", "Q-ciprofloxacin", "Q-ciprofloxacin", "Q-ciprofloxacin", "Ran-ciprofloxacin", "Ran-ciprofloxacin", "Ran-ciprofloxacin", "Ratio-ciprofloxacin", "Ratio-ciprofloxacin", "Ratio-ciprofloxacin", "Riva-ciprofloxacin", "Riva-ciprofloxacin", "Riva-ciprofloxacin", "Riva-ciprofloxacin", "Sandoz Ciprofloxacin", "Sandoz Ciprofloxacin", "Sandoz Ciprofloxacin", "Sandoz Ciprofloxacin", "Sandoz Ciprofloxacin / Dexamethasone", "Septa-ciprofloxacin", "Septa-ciprofloxacin", "Septa-ciprofloxacin", "Taro-ciproflox", "Taro-ciproflox", "Taro-ciproflox", "Taro-ciprofloxacin", "Taro-ciprofloxacin", "Taro-ciprofloxacin", "Taro-ciprofloxacin/dexamethasone", "Teva-ciprofloxacin", "Teva-ciprofloxacin", "Teva-ciprofloxacin", "Truemed Group LLC", "Van-ciprofloxacin", "Van-ciprofloxacin", "Van-ciprofloxacin" ]	[ "Bacquinor", "Baycip", "Ciflox", "Cifloxin", "Ciprinol", "Ciprobay", "Ciprocinol", "Ciprodar", "Ciproxan", "Ciproxin", "Flociprin", "Proquin" ]	[ "Cipro", "Ciprodex", "Cipro HC", "Ciprodex", "Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin", "Cipro XR", "Cipro XR", "Cipro XR", "Cipro XR", "Ciprodex", "Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin", "Ciprodex", "Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin", "Ciprofloxacin", "Cipro HC", "Ciprodex", "Ciprofloxacin and Fluocinolone Acetonide", "Cipro HC", "Ciprodex", "Cipro", "Cipro", "Cipro", "Cipro", "Otovel", "Ciprodex", "Ciprofloxacin and Dexamethasone", "Ciprofloxacin and Dexamethasone", "Ciprofloxacin and Dexamethasone", "Ciprofloxacin and Fluocinolone Acetonide", "Otovel", "Cipro HC Otic Suspension", "Ciprodex", "Otixal", "Taro-ciprofloxacin/dexamethasone", "Sandoz Ciprofloxacin / Dexamethasone", "Cipro HC", "Cipro HC", "Ciprofloxacin and Dexamethasone", "Ciprofloxacin and dexamethasone", "Cipro HC", "Ciprofloxacin and dexamethasone", "Ciprofloxacin and Dexamethasone", "Ciprofloxacin and Dexamethasone", "Ciprofloxacin and dexamethasone", "Cipro HC", "Ciprofloxacin and Dexamethasone", "Cipro HC" ]	[ "P11388", "Q12809" ]	[ "P05177", "P08684", "P20815", "P24462" ]	[ "P02768" ]	[ "P08183", "Q96FL8", "Q86VL8" ]
DB00538	Gadoversetamide	Gadoversetamide, marketed under the trade name OptiMARK, is a gadolinium compound used as a contrast agent in magnetic resonance imaging (MRI), particularly imaging of the brain, spine and liver.	solid	Gadoversetamide is an MRI contrast agent used for MRI diagnostic procedures to provide increased enhancement and visualization of lesions of the brain, spine and liver, including tumors.	null	Based on the behavior of protons when placed in a strong magnetic field, which is interpreted and transformed into images by magnetic resonance (MR) instruments. MR images are based primarily on proton density and proton relaxation dynamics. MR instruments are sensitive to two different relaxation processes, the T1 (spin-lattice or longitudinal relaxation time) and T2 (spin-spin or transverse relaxation time). Paramagnetic agents contain one or more unpaired electrons that enhance the T1 and T2 relaxation rates of protons in their molecular environment. In MRI, visualization of normal and pathological brain, spinal and hepatic tissue depends in part on variations in the radio frequency signal intensity that occur with changes in proton density, alteration of the T1, and variation in T2. When placed in a magnetic field, gadoversetamide shortens the T1 and T2 relaxation times in tissues where it accumulates. At the recommended dose, the effect is primarily on T1 relaxation time, and produces an increase in signal intensity (brightness). Gadoversetamide does not cross the intact blood-brain barrier; therefore, it does not accumulate in normal brain tissue or in CNS lesions that may have a normal blood-brain barrier (e.g., cysts, mature post-operative scars). Abnormal vascularity or disruption of the blood-brain barrier allows accumulation of gadoversetamide in lesions such as neoplasms, abscesses, and subacute infarcts.	null	None detected	null	Distribution 13.3 ± 6.8 (mean) minutes, elimination 103.6 ± 19.5 (mean) minutes.	null	The mean cumulative urinary excretion of gadoversetamide at 72 hours was approximately 93.5% for renal impaired patients and 95.8% for subjects with normal renal function	* 162 ± 25 mL/kg [normal subjects]	* 72 +/- 16.3 mL/hr/kg [healthy]	Organic compounds	Organic acids and derivatives	Carboxylic acids and derivatives	Amino acids, peptides, and analogues	[ "approved", "investigational" ]	[ "V08CA", "V08C", "V08", "V" ]	[ "Humans and other mammals" ]	[ { "cost": "4.49", "description": "Optimark 330.9 mg/ml vial", "unit": "ml" } ]	[ { "approved": "1992-07-14", "country": "United States", "expires": "2009-07-14", "number": "5130120" } ]	Gadoversetamid \| Gadoversetamida \| Gadoversetamide \| Gadoversetamidum	[ "Optimark", "Optimark", "Optimark", "Optimark", "Optimark", "Optimark", "Optimark", "Optimark", "Optimark", "Optimark", "Optimark", "Optimark", "Optimark", "Optimark", "Optimark", "Optimark", "Optimark", "Optimark", "Optimark", "Optimark" ]	[]	[]	[]	[]	[]	[]
DB00539	Toremifene	Toremifene is a selective estrogen receptor modulator (SERM) and a nonsteroidal antiestrogen used to treat estrogen receptor positive breast cancer.[A256923] Like [tamoxifen], toremifene is part of the first-generation triphenylethylene derivative chemical class of SERMs.[A256928] Toremifene possesses tissue-specific actions: it has estrogenic (agonist) activity on the cardiovascular system and on bone tissue and it has weak estrogenic effects on uterine tissue, however, it also has antiestrogenic (estrogen-antagonist) activity on breast tissue.[A256923]	solid	For the treatment of metastatic breast cancer in postmenopausal women with estrogen receptor-positive or receptor-unknown tumors. Toremifene is currently under investigation as a preventative agent for prostate cancer in men with high-grade prostatic intraepithelial neoplasia and no evidence of prostate cancer.	Toremifene is an antineoplastic hormonal agent primarily used in the treatment of advanced breast cancer. Toremifene is a nonsteroidal agent that has demonstrated potent antiestrogenic properties in animal test systems. The antiestrogenic effects may be related to its ability to compete with estrogen for binding sites in target tissues such as breast. Toremifene inhibits the induction of rat mammary carcinoma induced by dimethylbenzanthracene (DMBA) and causes the regression of already established DMBA-induced tumors. In this rat model, Toremifene appears to exert its antitumor effects by binding the estrogen receptors. In cytosols derived from human breast adenocarcinomas, Toremifene competes with estradiol for estrogen receptor protein.	Toremifene is a nonsteroidal triphenylethylene derivative. Toremifene binds to estrogen receptors and may exert estrogenic, antiestrogenic, or both activities, depending upon the duration of treatment, animal species, gender, target organ, or endpoint selected. The antitumor effect of toremifene in breast cancer is believed to be mainly due to its antiestrogenic effects, in other words, its ability to compete with estrogen for binding sites in the cancer, blocking the growth-stimulating effects of estrogen in the tumor. Toremifene may also inhibit tumor growth through other mechanisms, such as induction of apoptosis, regulation of oncogene expression, and growth factors.	Well absorbed	Hepatic. Mainly by CYP3A4 to N-demethyltoremifene, which exhibits antiestrogenic effects but has weak antitumor potency in vivo.	null	5 days	Toremifen is primarily bound to albumin (92%), 2% bound to α1-acid glycoprotein, and 6% bound to β1-globulin in the serum.	Toremifene is extensively metabolized, principally by CYP3A4 to N-demethyltoremifene, which is also antiestrogenic but with weak in vivo antitumor potency.	* 580 L	* 5 L/h	Organic compounds	Phenylpropanoids and polyketides	Stilbenes	null	[ "approved", "investigational" ]	[ "L02BA", "L02B", "L02", "L" ]	[ "Humans and other mammals" ]	[ { "cost": "11.84", "description": "Fareston 60 mg tablet", "unit": "tablet" } ]	[ { "approved": "1987-09-29", "country": "United States", "expires": "2009-09-29", "number": "4696949" } ]	Toremifene \| Toremifeno \| Toremifenum \| ER \| ER-alpha \| ESR \| Estradiol receptor \| NR3A1 \| Nuclear receptor subfamily 3 group A member 1 \| ABP \| SBP \| Sex steroid-binding protein \| SHBG \| TeBG \| Testis-specific androgen-binding protein \| Testosterone-estradiol-binding globulin \| Testosterone-estrogen-binding globulin \| 1.14.14.1 \| CYPIA1 \| Cytochrome P450 form 6 \| Cytochrome P450-C \| Cytochrome P450-P1 \| Hydroperoxy icosatetraenoate dehydratase \| 1,4-cineole 2-exo-monooxygenase \| 1,8-cineole 2-exo-monooxygenase \| 1.14.14.1 \| Albendazole monooxygenase (sulfoxide-forming) \| Albendazole sulfoxidase \| Cholesterol 25-hydroxylase \| CYP3A3 \| CYPIIIA3 \| CYPIIIA4 \| Cytochrome P450 3A3 \| Cytochrome P450 HLp \| Cytochrome P450 NF-25 \| Cytochrome P450-PCN1 \| Nifedipine oxidase \| Quinine 3-monooxygenase \| ATP-binding cassette sub-family B member 1 \| MDR1 \| Multidrug resistance protein 1 \| P-glycoprotein 1 \| PGY1 \| Phospholipid transporter ABCB1	[ "Fareston", "Fareston", "Fareston", "Fareston", "Toremifene Citrate", "Toremifene Citrate", "Toremifene Citrate" ]	[ "Acapodene" ]	[]	[ "P03372", "P04278" ]	[ "P04798", "P08684" ]	[]	[ "P08183" ]
DB00540	Nortriptyline	Nortriptyline hydrochloride, the active metabolite of [amitriptyline], is a tricyclic antidepressant (TCA).[L11878] It is used in the treatment of major depression and is also used off-label for chronic pain and other conditions.[L11881]	solid	Nortriptyline is indicated for the relief of the symptoms of major depressive disorder (MDD).[L11878] Some off-label uses for this drug include treatment of chronic pain, myofascial pain, neuralgia, and irritable bowel syndrome.[A191083,L11878]	Nortriptyline exerts antidepressant effects likely by inhibiting the reuptake of serotonin and norepinephrine at neuronal cell membranes. It also exerts antimuscarinic effects through its actions on the acetylcholine receptor.[L11878,L11881]	Though prescribing information does not identify a specific mechanism of action for nortriptyline[L11878], is believed that nortriptyline either inhibits the reuptake of the neurotransmitter serotonin at the neuronal membrane or acts at the level of the beta-adrenergic receptors. It displays a more selective reuptake inhibition for noradrenaline, which may explain increased symptom improvement after nortriptyline therapy.[T28] Tricyclic antidepressants do not inhibit monoamine oxidase nor do they affect dopamine reuptake.[L11878] As with other tricyclics, nortriptyline displays affinity for other receptors including mACh receptors, histamine receptors, 5-HT receptors, in addition to other receptors.[A18198,A4909,T28]	Nortriptyline is readily absorbed in the gastrointestinal tract with extensive variation in plasma levels, depending on the patient. This drug undergoes first-pass metabolism and its plasma concentrations are attained within 7 to 8.5 hours after oral administration.[L11899] The bioavailability of nortriptyline varies considerably and ranges from 45 to 85%.[A191167,L11911]	Nortriptyline is metabolized via demethylation and hydroxylation in the liver followed by glucuronic acid conjugation. CYP2D6 plays a large role in nortriptyline metabolism, with contributions from CYP1A2, CYP2C19 and CYP3A4.[A15182,L11878,A14832] The main active metabolite is 10-hydroxynortriptyline exists in both cis and a trans form, with the trans form is higher in potency. 10-hydroxynortriptyline is the most frequently found in the plasma. Most of the other metabolites are conjugated, and are less potent.[L11911]	The oral LD50 of nortriptyline in the rat is 405 mg/kg.[L11920]Symptoms of overdose with nortriptyline include cardiac arrhythmias, severe hypotension, shock, congestive heart failure, pulmonary edema, convulsions, coma, and CNS depression.[L11878,L11899] Changes in the electrocardiogram, particularly in QRS segment, may be indicative of tricyclic antidepressant toxicity.[A191170]	The average plasma half-life of nortriptyline in healthy volunteers is about 26 hours, but is said to range from 16 to 38 hours.[A191098,L11878,L11911] One study mentions a mean half-life of about 39 hours.[A191101]	The plasma protein binding of nortriptyline is approximately 93%.[L11911]	Nortriptyline and its metabolites are mainly excreted in the urine, where only small amounts (2%) of the total drug is recovered as unchanged parent compound.[L11911] Approximately one-third of a single orally administered dose is excreted in urine within 24 hours.[L11899] Small amounts are excreted in feces via biliary elimination.[L11911]	The apparent volume of distribution (Vd)β, estimated after intravenous administration is 1633 ± 268 L within the range of 1460 to 2030 (21 ± 4 L/kg).[L11911] Nortriptyline crosses the placenta and is found in the breast milk. It distributes to the heart, lungs, brain, and the liver.[L11899]	The average plasma clearance of nortriptyline in a study of healthy volunteers was 54 L/h.[A191098] The average systemic clearance of nortriptyline is 30.6 ± 6.9 L / h, within the range of 18.6 to 39.6 L/hour.[L11911]	Organic compounds	Benzenoids	Dibenzocycloheptenes	null	[ "approved" ]	[ "N06AA", "N06A", "N06", "N" ]	[ "Humans and other mammals" ]	[ { "cost": "1.33", "description": "Nortriptyline hcl 75 mg capsule", "unit": "capsule" }, { "cost": "11.09", "description": "Nortriptyline hcl powder", "unit": "g" }, { "cost": "19.34", "description": "Pamelor 75 mg capsule", "unit": "capsule" }, { "cost": "24.04", "description": "Pamelor 10 mg capsule", "unit": "capsule" }, { "cost": "24.04", "description": "Pamelor 25 mg capsule", "unit": "capsule" }, { "cost": "24.04", "description": "Pamelor 50 mg capsule", "unit": "capsule" }, { "cost": "325.97", "description": "Pamelor 10 mg/5ml Solution 480ml Bottle", "unit": "bottle" }, { "cost": "750.05", "description": "Pamelor 30 10 mg capsule Bottle", "unit": "bottle" }, { "cost": "750.05", "description": "Pamelor 30 25 mg capsule Bottle", "unit": "bottle" }, { "cost": "750.05", "description": "Pamelor 30 50 mg capsule Bottle", "unit": "bottle" }, { "cost": "0.13", "description": "Apo-Nortriptyline 10 mg Capsule", "unit": "capsule" }, { "cost": "0.13", "description": "Novo-Nortriptyline 10 mg Capsule", "unit": "capsule" }, { "cost": "0.13", "description": "Nu-Nortriptyline 10 mg Capsule", "unit": "capsule" }, { "cost": "0.13", "description": "Pms-Nortriptyline 10 mg Capsule", "unit": "capsule" }, { "cost": "0.24", "description": "Aventyl 10 mg Capsule", "unit": "capsule" }, { "cost": "0.27", "description": "Apo-Nortriptyline 25 mg Capsule", "unit": "capsule" }, { "cost": "0.27", "description": "Novo-Nortriptyline 25 mg Capsule", "unit": "capsule" }, { "cost": "0.27", "description": "Nu-Nortriptyline 25 mg Capsule", "unit": "capsule" }, { "cost": "0.27", "description": "Pms-Nortriptyline 25 mg Capsule", "unit": "capsule" }, { "cost": "0.28", "description": "Nortriptyline hcl 10 mg capsule", "unit": "capsule" }, { "cost": "0.4", "description": "Nortriptyline HCl 10 mg/5ml Solution", "unit": "ml" }, { "cost": "0.48", "description": "Aventyl 25 mg Capsule", "unit": "capsule" }, { "cost": "0.6", "description": "Nortriptyline hcl 25 mg capsule", "unit": "capsule" }, { "cost": "0.94", "description": "Nortriptyline hcl 50 mg capsule", "unit": "capsule" } ]	[]	10,11-dihydro-N-methyl-5H-dibenzo[a,d]cycloheptene-Δ5,γ-propylamine \| 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine \| Demethylamitriptyline \| Desmethylamitriptyline \| Nortriptylina \| Nortriptyline \| Nortriptylinum \| NAT1 \| NET \| NET1 \| Norepinephrine transporter \| SLC6A5 \| Solute carrier family 6 member 2 \| 5HT transporter \| 5HTT \| HTT \| SERT \| Solute carrier family 6 member 4 \| 5-HT-2 \| 5-HT-2A \| HTR2 \| Serotonin receptor 2A \| 5-HT-1A \| 5-HT1A \| ADRB2RL1 \| ADRBRL1 \| G-21 \| Serotonin receptor 1A \| H1-R \| H1R \| HH1R \| ADRA1C \| Alpha-1A adrenoceptor \| Alpha-1A adrenoreceptor \| Alpha-1C adrenergic receptor \| Alpha-adrenergic receptor 1c \| ADRA1A \| Alpha-1A adrenergic receptor \| Alpha-1D adrenoceptor \| Alpha-1D adrenoreceptor \| Alpha-adrenergic receptor 1a \| 5-HT-1C \| 5-HT-2C \| 5-HT1C \| 5-HT2C \| 5-HTR2C \| 5-hydroxytryptamine receptor 1C \| HTR1C \| Serotonin receptor 2C \| Alpha-1B adrenoceptor \| Alpha-1B adrenoreceptor \| ADRA2R \| ADRAR \| Alpha-2 adrenergic receptor subtype C10 \| Alpha-2A adrenoceptor \| Alpha-2A adrenoreceptor \| Alpha-2AAR \| ADRA2L1 \| ADRA2RL1 \| Alpha-2 adrenergic receptor subtype C2 \| Alpha-2B adrenoceptor \| Alpha-2B adrenoreceptor \| Alpha-2BAR \| ADRA2L2 \| ADRA2RL2 \| Alpha-2 adrenergic receptor subtype C4 \| Alpha-2C adrenoceptor \| Alpha-2C adrenoreceptor \| Alpha-2CAR \| ADRB1R \| B1AR \| Beta-1 adrenoceptor \| Beta-1 adrenoreceptor \| ADRB2R \| B2AR \| Beta-2 adrenoceptor \| Beta-2 adrenoreceptor \| ADRB3R \| B3AR \| Beta-3 adrenoceptor \| Beta-3 adrenoreceptor \| Dopamine D2 receptor \| Dap1 \| HPR6.6 \| IZA \| mPR \| PGRMC \| Aging-associated gene 8 protein \| hSigmaR1 \| OPRS1 \| SIG-1R \| Sigma 1-type opioid receptor \| Sigma1-receptor \| Sigma1R \| SR-BP \| SR31747-binding protein \| SRBP \| 5-HT-1C \| 5-HT-2C \| 5-HT1C \| 5-hydroxytryptamine receptor 1C \| 5ht1c \| Htr1c \| Serotonin receptor 2C \| 1.14.14.- \| Cholesterol 25-hydroxylase \| CYP2DL1 \| CYPIID6 \| Cytochrome P450-DB1 \| Debrisoquine 4-hydroxylase \| 1,4-cineole 2-exo-monooxygenase \| 1,8-cineole 2-exo-monooxygenase \| 1.14.14.1 \| Albendazole monooxygenase (sulfoxide-forming) \| Albendazole sulfoxidase \| Cholesterol 25-hydroxylase \| CYP3A3 \| CYPIIIA3 \| CYPIIIA4 \| Cytochrome P450 3A3 \| Cytochrome P450 HLp \| Cytochrome P450 NF-25 \| Cytochrome P450-PCN1 \| Nifedipine oxidase \| Quinine 3-monooxygenase \| 1.14.14.1 \| Cholesterol 25-hydroxylase \| CYPIA2 \| Cytochrome P(3)450 \| Cytochrome P450 4 \| Cytochrome P450-P3 \| Hydroperoxy icosatetraenoate dehydratase \| (R)-limonene 6-monooxygenase \| (S)-limonene 6-monooxygenase \| (S)-limonene 7-monooxygenase \| 1.14.14.1 \| CYPIIC17 \| CYPIIC19 \| Cytochrome P450-11A \| Cytochrome P450-254C \| Fenbendazole monooxygenase (4'-hydroxylating) \| Mephenytoin 4-hydroxylase \| 1.14.14.1 \| CYPIIIA5 \| Cytochrome P450-PCN3 \| 1.14.14.1 \| 4-nitrophenol 2-hydroxylase \| CYP2E \| CYPIIE1 \| Cytochrome P450-J \| AGP 1 \| AGP1 \| OMD 1 \| Orosomucoid-1 \| NAT1 \| NET \| NET1 \| Norepinephrine transporter \| SLC6A5 \| Solute carrier family 6 member 2 \| ATP-binding cassette sub-family B member 1 \| MDR1 \| Multidrug resistance protein 1 \| P-glycoprotein 1 \| PGY1 \| Phospholipid transporter ABCB1	[ "Apo-nortriptyline", "Apo-nortriptyline", "Ava-nortriptyline", "Ava-nortriptyline", "Aventyl", "Aventyl", "Dom-nortriptyline 10mg Capsules", "Dom-nortriptyline 25mg Capsules", "Gen-nortriptyline Capsules 10mg", "Gen-nortriptyline Capsules 25mg", "Nortriptyline", "Nortriptyline", "Nortriptyline", "Nortriptyline", "Nortriptyline Hci", "Nortriptyline HCL", "Nortriptyline HCL", "Nortriptyline HCL", "Nortriptyline HCL", "Nortriptyline HCL", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline Hydrochloride", "Nortriptyline-10", "Nortriptyline-25", "Norventyl", "Norventyl", "Pamelor", "Pamelor", "Pamelor", "Pamelor", "Pamelor", "PMS-nortriptyline", "PMS-nortriptyline", "Ratio-nortriptyline", "Ratio-nortriptyline", "Teva-nortriptyline", "Teva-nortriptyline" ]	[ "Allegron", "Ateben", "Avantyl", "Noritren", "Norpress", "Nortrilen", "Psychostyl", "Sensaval", "Sensoval" ]	[]	[ "P23975", "P31645", "P28223", "P08908", "P35367", "P35348", "P25100", "P28335", "P35368", "P08913", "P18089", "P18825", "P08588", "P07550", "P13945", "P14416", "O00264", "Q99720", "P11229", "P08172", "P20309", "P08173", "P08912" ]	[ "P10635", "P08684", "P05177", "P33261", "P20815", "P05181" ]	[ "P02768", "P02763" ]	[ "P23975", "P08183" ]
DB00541	Vincristine	Vincristine is an antitumor vinca alkaloid isolated from Vinca Rosea. It is marketed under several brand names, many of which have different formulations such as Marqibo (liposomal injection) and Vincasar. Vincristine is indicated for the treatment of acute leukaemia, malignant lymphoma, Hodgkin's disease, acute erythraemia, and acute panmyelosis. vincristine sulfate is often chosen as part of polychemotherapy because of lack of significant bone–marrow suppression (at recommended doses) and of unique clinical toxicity (neuropathy).	solid	Treatment of acute lymphocytic leukemia (ALL), Hodgkin lymphoma, non-Hodgkin lymphomas, Wilms' tumor, neuroblastoma, rhabdomyosarcoma. Liposomal vincristine is indicated for the treatment of relapsed Philadelphia chromosome-negative (Ph-) acute lymphoblastic leukemia (ALL).	Vincristine is a vinca alkaloid antineoplastic agent used as a treatment for various cancers including breast cancer, Hodgkin's disease, Kaposi's sarcoma, and testicular cancer. The vinca alkaloids are structurally similar compounds comprised of 2 multiringed units, vindoline and catharanthine. The vinca alkaloids have become clinically useful since the discovery of their antitumour properties in 1959. Initially, extracts of the periwinkle plant (Catharanthus roseus) were investigated because of putative hypoglycemic properties, but were noted to cause marrow suppression in rats and antileukemic effects <i>in vitro</i>. Vincristine binds to the microtubular proteins of the mitotic spindle, leading to crystallization of the microtubule and mitotic arrest or cell death. Vincristine has some immunosuppressant effect. The vinca alkaloids are considered to be cell cycle phase-specific.	The antitumor activity of Vincristine is thought to be due primarily to inhibition of mitosis at metaphase through its interaction with tubulin. Like other vinca alkaloids, Vincristine may also interfere with: 1) amino acid, cyclic AMP, and glutathione metabolism, 2) calmodulin-dependent Ca<sup>2+</sup>-transport ATPase activity, 3) cellular respiration, and 4) nucleic acid and lipid biosynthesis.	null	Hepatic. Cytochrome P450 isoenzymes of the CYP3A subfamily facilitate the metabolism of vincristine.	IVN-RAT LD<sub>50</sub> 1300 mg/kg; IPR-MUS LD<sub>50</sub> 5.2 mg/kg. Marqibo® must only be administered IV because it is fatal if administered by other routes. Marqibo® also has different dosing than vincristine sulphate injection, so attention is needed to prevent overdoses. The most clinically significant adverse effect of vincristine is neurotoxicity.	When intravenously injected into cancer patients, a triphasic serum decay patten was observed. The initial, middle, and terminal half-lives are 5 minutes, 2.3 hours, 85 hours respectively. The range of the terminal half-life is humans is 19 - 155 hours.	~75%	The liver is the major excretory organ in humans and animals. 80% of an injected dose of vincristine sulfate is excreted via feces. 10 - 20% is excreted via urine.	Within 15 to 30 minutes after injection, over 90% of the drug is distributed from the blood into tissue, where it remains tightly, but not irreversibly, bound.	null	Organic compounds	Alkaloids and derivatives	Vinca alkaloids	null	[ "approved", "investigational" ]	[ "L01CA", "L01C", "L01", "L" ]	[ "Humans and other mammals" ]	[ { "cost": "18.06", "description": "Vincristine 2 mg/2 ml vial", "unit": "ml" }, { "cost": "0.19", "description": "Oncovite tablet", "unit": "tablet" } ]	[ { "approved": "2004-04-20", "country": "United States", "expires": "2020-03-31", "number": "6723338" }, { "approved": "2011-02-15", "country": "United States", "expires": "2020-03-31", "number": "7887836" }, { "approved": "2007-07-24", "country": "United States", "expires": "2020-09-25", "number": "7247316" } ]	22-Oxovincaleukoblastin \| 22-Oxovincaleukoblastine \| Leurocristine \| Vincristin \| Vincristina \| Vincristine \| Vincristinum \| TUBB5 \| Tubulin beta-5 chain \| 3.6.5.- \| Alpha-tubulin 1 \| Testis-specific alpha-tubulin \| TUBA1 \| Tubulin alpha-1 chain \| Tubulin H2-alpha \| 1,4-cineole 2-exo-monooxygenase \| 1,8-cineole 2-exo-monooxygenase \| 1.14.14.1 \| Albendazole monooxygenase (sulfoxide-forming) \| Albendazole sulfoxidase \| Cholesterol 25-hydroxylase \| CYP3A3 \| CYPIIIA3 \| CYPIIIA4 \| Cytochrome P450 3A3 \| Cytochrome P450 HLp \| Cytochrome P450 NF-25 \| Cytochrome P450-PCN1 \| Nifedipine oxidase \| Quinine 3-monooxygenase \| 1.14.14.1 \| CYPIIIA5 \| Cytochrome P450-PCN3 \| 1.14.14.1 \| CYPIIIA7 \| Cytochrome P450-HFLA \| P450HLp2 \| ATP-binding cassette sub-family B member 1 \| MDR1 \| Multidrug resistance protein 1 \| P-glycoprotein 1 \| PGY1 \| Phospholipid transporter ABCB1 \| 7.6.2.- \| 7.6.2.2 \| 7.6.2.3 \| Canalicular multispecific organic anion transporter 2 \| CMOAT2 \| MLP2 \| MOAT-D \| MRP3 \| Multi-specific organic anion transporter D \| Multidrug resistance-associated protein 3 \| EMT \| EMTH \| Extraneuronal monoamine transporter \| OCT3 \| Organic cation transporter 3 \| 7.6.2.2 \| ATP-binding cassette sub-family C member 1 \| Glutathione-S-conjugate-translocating ATPase ABCC1 \| Leukotriene C(4) transporter \| LTC4 transporter \| MRP \| MRP1 \| 7.6.2.2 \| 7.6.2.3 \| MRP7 \| Multidrug resistance-associated protein 7 \| SIMRP7 \| 7.6.2.- \| 7.6.2.2 \| 7.6.2.3 \| Canalicular multidrug resistance protein \| Canalicular multispecific organic anion transporter 1 \| CMOAT \| CMOAT1 \| CMRP \| MRP2 \| Multidrug resistance-associated protein 2 \| 7.6.2.- \| ATP-binding cassette sub-family B member 11 \| BSEP \| 7.6.2.2 \| ABCP \| ATP-binding cassette sub-family G member 2 \| BCRP \| BCRP1 \| Breast cancer resistance protein \| CDw338 \| Mitoxantrone resistance-associated protein \| MXR \| Placenta-specific ATP-binding cassette transporter \| Urate exporter \| 76 kDa Ral-interacting protein \| Dinitrophenyl S-glutathione ATPase \| DNP-SG ATPase \| Ral-interacting protein 1 \| RalBP1 \| RLIP \| RLIP1 \| RLIP76 \| Liver-specific organic anion transporter 1 \| LST-1 \| LST1 \| OATP-2 \| OATP-C \| OATP1B1 \| OATP2 \| OATPC \| Organic anion transporter SLC21A6 \| SLC21A6 \| SLCO1B1 \| Sodium-independent organic anion-transporting polypeptide 2 \| Solute carrier family 21 member 6 \| Liver-specific organic anion transporter 2 \| LST-2 \| LST2 \| OATP-8 \| OATP1B3 \| OATP8 \| Organic anion transporter 8 \| Organic anion-transporting polypeptide 8 \| SLC21A8 \| Solute carrier family 21 member 8	[ "Marqibo", "Marqibo", "Oncovin Solution 1mg/ml", "Vincasar PFS", "Vincasar PFS", "VinCRIStine Sulfate", "Vincristine Sulfate Inj 1mg/ml USP", "Vincristine Sulfate Inj 5mg/vial USP", "Vincristine Sulfate Injection", "Vincristine Sulfate Injection", "Vincristine Sulfate Injection USP", "Vincristine Sulfate Injection USP" ]	[ "Alcavixin", "Alcrist", "Citomid", "Cytocristin", "Oncocristin", "Oncovin", "Oncrivin", "Sindovin", "Tevacristin", "Vinces", "Vincrisin", "Vincristin", "Vincrisul", "Vinlon", "Vinracine" ]	[]	[ "P07437", "P68366" ]	[ "P08684", "P20815", "P24462" ]	[]	[ "P08183", "O15438", "O75751", "P33527", "Q5T3U5", "Q92887", "O95342", "Q9UNQ0", "Q15311", "Q9Y6L6", "Q9NPD5" ]
DB00542	Benazepril	Benazepril, brand name Lotensin, is a medication used to treat high blood pressure (hypertension), congestive heart failure, and chronic renal failure[A838,A837]. Upon cleavage of its ester group by the liver, benazepril is converted into its active form benazeprilat, a non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor[A836].	solid	Benazepril is indicated for the treatment of hypertension[A840]. It may be used alone or in combination with thiazide diuretics[FDA Label].	Benazepril, an angiotensin-converting enzyme (ACE) inhibitor, is a prodrug which, when hydrolyzed by esterases to its active Benazeprilat[A836], is used to treat hypertension and heart failure, to reduce proteinuria and renal disease in patients with nephropathies, and to prevent stroke, myocardial infarction, and cardiac death in high-risk patients[A840,A838,A837]. Benazepril and Benazeprilat inhibit angiotensin-converting enzyme (ACE) in human subjects and animals[A840,A836]. ACE is a peptidyl dipeptidase that catalyzes the conversion of angiotensin I to the vasoconstrictor substance, angiotensin II[FDA Label]. Angiotensin II also stimulates aldosterone secretion by the adrenal cortex[FDA Label].	Benazeprilat, the active metabolite of Benazepril, competes with angiotensin I for binding at the angiotensin-converting enzyme, blocking the conversion of angiotensin I to angiotensin II[FDA Label]. Inhibition of ACE results in decreased plasma angiotensin II[FDA Label]. As angiotensin II is a vasoconstrictor and a negative-feedback mediator for renin activity, lower concentrations result in a decrease in blood pressure and stimulation of baroreceptor reflex mechanisms, which leads to decreased vasopressor activity and to decreased aldosterone secretion[FDA Label].	Bioavailability of oral dosing is 3% to 4% in horses[A176450]. In humans at least 37% of oral benazepril is absorbed and reaches peak plasma concentration in 0.5 hours to 1 hour[A176453]. Other studies have shown a peak plasma concentration at a median of 1.5 hours[A836].	Cleavage of the ester group (primarily in the liver) converts benazepril to its active metabolite, benazeprilat[FDA Label]. Benazepril and benazeprilat are conjugated to glucuronic acid prior to urinary excretion[FDA Label].	The most common adverse effects include headache, dizziness, fatigue, somnolence, postural dizziness, nausea, and cough[FDA Label,A839]. The most likely symptom of overdosage is severe hypotension[FDA Label].	The half life of the prodrug benazepril is 2.7±8.5h[A836]. The half life of the active metabolite benazeprilat is 22.3±9.2h[A836] The accumulation half life of benazepril is 10 to 11 hours[FDA Label][A836].	Benazepril is 96.7% protein bound while benazeprilat is 95.3% protein bound[FDA Label].	Benazepril and benazeprilat are cleared predominantly by renal excretion in healthy subjects with normal renal function[FDA Label]. Nonrenal (i.e., biliary) excretion accounts for approximately 11%-12% of benazeprilat excretion in healthy subjects[FDA Label].	The final population pharmacokinetic model in one study estimated the volume of distribution to be 203±69.9L[F4169].	The final population pharmacokinetic model of one study estimates the clearance to be 129±30.0L[F4169].	Organic compounds	Organic acids and derivatives	Carboxylic acids and derivatives	Amino acids, peptides, and analogues	[ "approved", "investigational" ]	[ "C09BB", "C09B", "C09", "C", "C09BA", "C09B", "C09", "C", "C09AA", "C09A", "C09", "C" ]	[ "Humans and other mammals" ]	[ { "cost": "1.07", "description": "Benazepril hcl 10 mg tablet", "unit": "tablet" }, { "cost": "1.07", "description": "Benazepril hcl 20 mg tablet", "unit": "tablet" }, { "cost": "1.07", "description": "Benazepril hcl 40 mg tablet", "unit": "tablet" }, { "cost": "1.07", "description": "Benazepril hcl 5 mg tablet", "unit": "tablet" }, { "cost": "1.14", "description": "Lotensin 20 mg Tablet", "unit": "tablet" }, { "cost": "1.31", "description": "Lotensin HCT 5-6.25 mg tablet", "unit": "tablet" }, { "cost": "1.9", "description": "Lotensin hct 10-12.5 tablet", "unit": "tablet" }, { "cost": "1.9", "description": "Lotensin hct 20-12.5 tablet", "unit": "tablet" }, { "cost": "1.9", "description": "Lotensin hct 20-25 tablet", "unit": "tablet" }, { "cost": "1.9", "description": "Lotensin hct 5-6.25 tablet", "unit": "tablet" }, { "cost": "1.94", "description": "Lotensin HCT 20-25 mg tablet", "unit": "tablet" }, { "cost": "1.95", "description": "Lotensin HCT 10-12.5 mg tablet", "unit": "tablet" }, { "cost": "1.97", "description": "Lotensin HCT 20-12.5 mg tablet", "unit": "tablet" }, { "cost": "2.0", "description": "Lotensin 10 mg tablet", "unit": "tablet" }, { "cost": "2.0", "description": "Lotensin 40 mg tablet", "unit": "tablet" }, { "cost": "2.0", "description": "Lotensin 5 mg tablet", "unit": "tablet" }, { "cost": "2.08", "description": "Lotensin 20 mg tablet", "unit": "tablet" }, { "cost": "0.58", "description": "Apo-Benazepril 5 mg Tablet", "unit": "tablet" }, { "cost": "0.69", "description": "Apo-Benazepril 10 mg Tablet", "unit": "tablet" }, { "cost": "0.79", "description": "Apo-Benazepril 20 mg Tablet", "unit": "tablet" }, { "cost": "0.84", "description": "Lotensin 5 mg Tablet", "unit": "tablet" }, { "cost": "0.99", "description": "Lotensin 10 mg Tablet", "unit": "tablet" } ]	[ { "approved": "2000-12-19", "country": "United States", "expires": "2017-12-19", "number": "6162802" } ]	Bénazépril \| Benazepril \| Benazeprilum \| 3.4.15.1 \| ACE \| DCP \| DCP1 \| Dipeptidyl carboxypeptidase I \| Kininase II \| 1.5.1.53 \| Intestinal H(+)/peptide cotransporter \| Oligopeptide transporter, small intestine isoform \| PEPT1 \| Peptide transporter 1 \| Kidney H(+)/peptide cotransporter \| Oligopeptide transporter, kidney isoform \| PEPT2 \| Peptide transporter 2	[ "Amlobenz", "Amlobenz", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and 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Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amoldipine Benazepril HCl", "Benazepril", "Benazepril", "Benazepril", "Benazepril", "Benazepril", "Benazepril", "Benazepril and Hydrochlorothiazide", "Benazepril and Hydrochlorothiazide", "Benazepril and Hydrochlorothiazide", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril hydrochloride", "Benazepril hydrochloride", "Benazepril hydrochloride", "Benazepril hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril hydrochloride", "Benazepril hydrochloride", "Benazepril hydrochloride", "Benazepril hydrochloride", "Benazepril hydrochloride", "Benazepril hydrochloride", "Benazepril hydrochloride", "Benazepril hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride", "Benazepril hydrochloride", "Benazepril hydrochloride", "Benazepril hydrochloride", "Benazepril hydrochloride", "Benazepril Hydrochloride", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril hydrochloride and hydrochlorothiazide", "Benazepril hydrochloride and hydrochlorothiazide", "Benazepril hydrochloride and hydrochlorothiazide", "Benazepril hydrochloride and hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Lotensin", "Lotensin", "Lotensin", "Lotensin", "Lotensin", "Lotensin", "Lotensin", "Lotensin", "Lotensin", "Lotensin", "Lotensin", "Lotensin", "Lotensin", "Lotensin 10mg", "Lotensin 20mg", "Lotensin 5mg", "Lotensin HCT", "Lotensin HCT", "Lotensin HCT", "Lotensin HCT", "Lotensin HCT", "Lotensin HCT", "Lotensin HCT", "Lotensin HCT", "Lotensin HCT", "Lotrel", "Lotrel", "Lotrel", "Lotrel", "Lotrel", "Lotrel", "Lotrel", "Lotrel", "Lotrel", "Lotrel", "Lotrel", "Lotrel", "Lotrel", "Lotrel", "Lotrel", "Lotrel", "Lotrel", "Lotrel", "Lotrel", "Lotrel", "Lotrel", "PMS-benazepril", "PMS-benazepril", "PMS-benazepril" ]	[ "Briem", "Cibacen", "Cibacen WS", "Cibacene" ]	[ "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Amlobenz", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlobenz", "Benazepril Hydrochloride and Hydrochlorothiazide", "Amlodipine besylate and benazepril hydrochloride", "Amlodipine besylate and benazepril hydrochloride", "Amlodipine besylate and benazepril hydrochloride", "Benazepril and Hydrochlorothiazide", "Benazepril and Hydrochlorothiazide", "Benazepril and Hydrochlorothiazide", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Lotensin HCT", "Lotensin HCT", "Lotrel", "Lotrel", "Lotrel", "Lotrel", "Lotrel", "Lotrel", "Lotrel", "Lotrel", "Lotrel", "Lotrel", "Lotrel", "Lotrel", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Lotensin HCT", "Lotensin HCT", "Lotensin HCT", "Lotensin HCT", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine besylate and benazepril hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Benazepril hydrochloride and hydrochlorothiazide", "Benazepril hydrochloride and hydrochlorothiazide", "Benazepril hydrochloride and hydrochlorothiazide", "Benazepril hydrochloride and hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Amlodipine Besylate and Benazepril HCL", "Amlodipine Besylate and Benazepril HCL", "Amlodipine Besylate and Benazepril HCL", "Amlodipine besylate and benazepril hydrochloride", "Amlodipine besylate and benazepril hydrochloride", "Amlodipine besylate and benazepril hydrochloride", "Amlodipine besylate and benazepril hydrochloride", "Amlodipine besylate and benazepril hydrochloride", "Amlodipine besylate and benazepril hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Benazepril Hydrochloride and Hydrochlorothiazide", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Benazepril Hydrochloride and Hydrochlorothiazide", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Amlodipine and Benazepril Hydrochloride", "Benazepril Hydrochloride and Hydrochlorothiazide", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Amlodipine besylate and Benazepril hydrochloride", "Amlodipine besylate and Benazepril hydrochloride", "Amlodipine besylate and Benazepril hydrochloride", "Amlodipine besylate and Benazepril hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Amoldipine Benazepril HCl", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Lotrel", "Lotrel", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Amlodipine Besylate and Benazepril Hydrochloride", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Lotrel", "Lotrel", "Lotrel", "Lotrel", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Lotensin HCT", "Lotensin HCT", "Lotensin HCT", "Amlodipine and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine besylate and benazepril hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine besylate and benazepril hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Lotrel", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Benazepril Hydrochloride and Hydrochlorothiazide", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Lotrel", "Lotrel", "Amlodipine and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Benazepril Hydrochloride and Hydrochlorothiazide", "Amlodipine and Benazepril Hydrochloride", "Amlodipine Besylate and Benazepril Hydrochloride", "Amlodipine and Benazepril Hydrochloride", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide", "Benazepril Hydrochloride and Hydrochlorothiazide" ]	[ "P12821" ]	[ "P42898" ]	[]	[ "P46059", "Q16348" ]
DB00543	Amoxapine	Amoxapine, the <i>N</i>-demethylated derivative of the antipsychotic agent loxapine, is a dibenzoxazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, amoxapine does not affect mood or arousal, but may cause sedation. In depressed individuals, amoxapine exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. In addition, TCAs down-regulate cerebral cortical β-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use. The antidepressant effects of TCAs are thought to be due to an overall increase in serotonergic neurotransmission. TCAs also block histamine H<sub>1</sub> receptors, α<sub>1</sub>-adrenergic receptors and muscarinic receptors, which accounts for their sedative, hypotensive and anticholinergic effects (e.g. blurred vision, dry mouth, constipation, urinary retention), respectively. See toxicity section below for a complete listing of side effects. Amoxapine may be used to treat neurotic and reactive depressive disorders, endogenous and psychotic depression, and mixed symptoms of depression and anxiety or agitation.	solid	For the relief of symptoms of depression in patients with neurotic or reactive depressive disorders as well as endogenous and psychotic depressions. May also be used to treat depression accompanied by anxiety or agitation.	Amoxapine is a tricyclic antidepressant of the dibenzoxazepine class, chemically distinct from the dibenzodiazepines, dibenzocycloheptenes, and dibenzoxepines. It has a mild sedative component to its action. The mechanism of its clinical action in man is not well understood. In animals, amoxapine reduced the uptake of nor-epinephirine and serotonin and blocked the response of dopamine receptors to dopamine. Amoxapine is not a monoamine oxidase inhibitor. Clinical studies have demonstrated that amoxapine has a more rapid onset of action than either amitriptyline or imipramine	Amoxapine acts by decreasing the reuptake of norepinephrine and serotonin (5-HT).	Rapidly and almost completely absorbed from the GI tract. Peak plasma concentrations occur within 1-2 hours of oral administration of a single dose.	Amoxapine is almost completely metabolized in the liver to its major metabolite, 8-hydroxyamoxapine, and a minor metabolite, 7-hydroxyamoxapine. Both metabolites are phamacologically inactive and have half-lives of approximately 30 and 6.5 hours, respectively.	Toxic manifestations of amoxapine overdosage differ significantly from those of other tricyclic antidepressants. Serious cardiovascular effects are seldom if ever observed. However, CNS effects, particularly grand mal convulsions, occur frequently, and treatment should be directed primarily toward prevention or control of seizures. Status epilepticus may develop and constitutes a neurologic emergency. Coma and acidosis are other serious complications of substantial amoxapine overdosage in some cases. Renal failure may develop two to five days after toxic overdose in patients who may appear otherwise recovered. Acute tubular necrosis with rhabdomuolysis and myolobinurla is the most common renal complication in such cases. This reaction probably occurs in less than 5% of overdose cases, and typically in those who have experienced multiple seizures.	8 hours	In vitro tests show that amoxapine binding to human plasma proteins is approximately 90%.	60-69% of a single orally administered dose of amoxapine is excreted in urine, principally as conjugated metabolites. 7-18% of the dose is excrete feces mainly as unconjugated metabolites. Less than 5% of the dose is excreted as unchanged drug in urine.	Widely distributed in body tissues with highest concentrations found in lungs, spleen, kidneys, heart, and brain. Lower concentrations can be detected in testes and muscle.	null	Organic compounds	Organoheterocyclic compounds	Benzoxazepines	Dibenzoxazepines	[ "approved" ]	[ "N06AA", "N06A", "N06", "N" ]	[ "Humans and other mammals" ]	[ { "cost": "1.02", "description": "Amoxapine 50 mg tablet", "unit": "tablet" }, { "cost": "1.7", "description": "Amoxapine 100 mg tablet", "unit": "tablet" }, { "cost": "2.63", "description": "Amoxapine 150 mg tablet", "unit": "tablet" }, { "cost": "82.15", "description": "Amoxapine 30 150 mg tablet Bottle", "unit": "bottle" }, { "cost": "0.63", "description": "Amoxapine 25 mg tablet", "unit": "tablet" } ]	[]	2-Chloro-11-(1-piperazinyl)dibenz(b,f)(1,4)oxazepine \| Amoxapin \| Amoxapina \| Amoxapine \| Amoxapinum \| Amoxepine \| Desmethylloxapin \| 5HT transporter \| 5HTT \| HTT \| SERT \| Solute carrier family 6 member 4 \| NAT1 \| NET \| NET1 \| Norepinephrine transporter \| SLC6A5 \| Solute carrier family 6 member 2 \| Dopamine D2 receptor \| Dopamine D1 receptor \| ADRA2R \| ADRAR \| Alpha-2 adrenergic receptor subtype C10 \| Alpha-2A adrenoceptor \| Alpha-2A adrenoreceptor \| Alpha-2AAR \| ADRA1C \| Alpha-1A adrenoceptor \| Alpha-1A adrenoreceptor \| Alpha-1C adrenergic receptor \| Alpha-adrenergic receptor 1c \| GABA(A) receptor subunit alpha-1 \| GABAAR subunit alpha-1 \| 5-HT-2 \| 5-HT-2A \| HTR2 \| Serotonin receptor 2A \| 5-HT-1C \| 5-HT-2C \| 5-HT1C \| 5-HT2C \| 5-HTR2C \| 5-hydroxytryptamine receptor 1C \| HTR1C \| Serotonin receptor 2C \| 5-HT-6 \| 5-HT6 \| Serotonin receptor 6 \| 5-HT-7 \| 5-HT-X \| 5-HT7 \| Serotonin receptor 7 \| Dopamine D3 receptor \| D(2C) dopamine receptor \| Dopamine D4 receptor \| H1-R \| H1R \| HH1R \| ADRA1C \| Alpha-1A adrenoceptor \| Alpha-1A adrenoreceptor \| Alpha-1C adrenergic receptor \| Alpha-adrenergic receptor 1c \| Alpha-1B adrenoceptor \| Alpha-1B adrenoreceptor \| ADRA1A \| Alpha-1A adrenergic receptor \| Alpha-1D adrenoceptor \| Alpha-1D adrenoreceptor \| Alpha-adrenergic receptor 1a \| 5-HT-2B \| 5-HT2B \| Serotonin receptor 2B \| 5-HT-3 \| 5-HT3-A \| 5-HT3A \| 5-HT3R \| 5-hydroxytryptamine receptor 3 \| 5HT3R \| HTR3 \| Serotonin receptor 3A \| Serotonin-gated ion channel receptor \| 5-HT-1A \| 5-HT1A \| ADRB2RL1 \| ADRBRL1 \| G-21 \| Serotonin receptor 1A \| 5-HT-1B \| 5-HT-1D-beta \| 5-HT1B \| HTR1DB \| S12 \| Serotonin 1D beta receptor \| Serotonin receptor 1B \| ADRA2R \| ADRAR \| Alpha-2 adrenergic receptor subtype C10 \| Alpha-2A adrenoceptor \| Alpha-2A adrenoreceptor \| Alpha-2AAR \| ADRA2L1 \| ADRA2RL1 \| Alpha-2 adrenergic receptor subtype C2 \| Alpha-2B adrenoceptor \| Alpha-2B adrenoreceptor \| Alpha-2BAR \| ADRA2L2 \| ADRA2RL2 \| Alpha-2 adrenergic receptor subtype C4 \| Alpha-2C adrenoceptor \| Alpha-2C adrenoreceptor \| Alpha-2CAR \| AXOR35 \| G-protein coupled receptor 105 \| GPCR105 \| GPRv53 \| H4R \| HH4R \| Pfi-013 \| SP9144 \| GABA(A) receptor subunit alpha-1 \| GABAAR subunit alpha-1 \| GABA(A) receptor subunit alpha-2 \| GABAAR subunit alpha-2 \| GABA(A) receptor subunit alpha-3 \| GABAAR subunit alpha-3 \| GABA(A) receptor subunit alpha-4 \| GABAAR subunit alpha-4 \| GABA(A) receptor subunit alpha-5 \| GABAAR subunit alpha-5 \| GABA(A) receptor subunit alpha-6 \| GABAAR subunit alpha-6 \| GABA(A) receptor subunit beta-1 \| GABAAR subunit beta-1 \| GABA(A) receptor subunit beta-2 \| GABAAR subunit beta-2 \| GABA(A) receptor subunit beta-3 \| GABAAR subunit beta-3 \| GABA(A) receptor subunit delta \| GABAAR subunit delta \| GABA(A) receptor subunit epsilon \| GABAAR subunit epsilon \| GABA(A) receptor subunit gamma-1 \| GABAAR subunit gamma-1 \| GABA(A) receptor subunit gamma-2 \| GABAAR subunit gamma-2 \| GABA(A) receptor subunit gamma-3 \| GABAAR subunit gamma-3 \| GABA(A) receptor subunit pi \| GABAAR subunit pi \| GABA(A) receptor subunit theta \| GABAAR subunit theta \| DA transporter \| DAT \| DAT1 \| Solute carrier family 6 member 3 \| 1.14.14.- \| Cholesterol 25-hydroxylase \| CYP2DL1 \| CYPIID6 \| Cytochrome P450-DB1 \| Debrisoquine 4-hydroxylase \| AGP 1 \| AGP1 \| OMD 1 \| Orosomucoid-1	[ "Amoxapine", "Amoxapine", "Amoxapine", "Amoxapine", "Amoxapine", "Amoxapine", "Amoxapine", "Amoxapine", "Amoxapine", "Asendin - Tab 100mg", "Asendin - Tab 25mg", "Asendin - Tab 50mg", "Asendin Tab 100mg", "Asendin Tab 25mg", "Asendin Tab 50mg" ]	[ "Adisen", "Amolife", "Amoxan", "Asendin", "Asendis", "Défanyl", "Demolox", "Oxamine", "Oxcap" ]	[]	[ "P31645", "P23975", "P14416", "P21728", "P08913", "P35348", "P11229", "P14867", "P28223", "P28335", "P50406", "P34969", "P35462", "P21917", "P35367", "P35348", "P35368", "P25100", "P11229", "P08172", "P20309", "P08173", "P08912", "P41595", "P46098", "P08908", "P28222", "P08913", "P18089", "P18825", "Q9H3N8", "P14867", "P47869", "P34903", "P48169", "P31644", "Q16445", "P18505", "P47870", "P28472", "O14764", "P78334", "Q8N1C3", "P18507", "Q99928", "O00591", "Q9UN88", "Q01959" ]	[ "P10635" ]	[ "P02763" ]	[]
DB00545	Pyridostigmine	Myasthenia gravis is an autoimmune disease involving dysfunction at the neuromuscular junction, most commonly due to autoantibodies directed against the acetylcholine receptor (AChR), which results in muscle tone loss, muscle weakness, and fatigue.[A231004] Acetylcholinesterase inhibitors have been the symptomatic treatment of choice in myasthenia gravis since the 1930s with the early use of [physostigmine] and [neostigmine]. By inhibiting the breakdown of acetylcholine in the neuromuscular junction, they increase signalling and relieve symptoms.[A231004, L32408, L32413] Pyridostigmine is the current drug of choice, with superior pharmacokinetics and reduced side effects compared to [neostigmine].[L32408, L32413] In addition to treating myasthenia gravis, pyridostigmine is used to reverse neuromuscular blocks, relieve symptoms in congenital myasthenic syndromes, and protect against certain nerve agents, notably during the Gulf War.[A231009, A231014, L32413, L32418] Pyridostigmine was granted initial FDA approval on April 6, 1955, as an oral tablet. Possible dose forms have been expanded to include extended-release tablets, syrups, and injections, marketed under various brand and generic names.[L32408, L32413]	solid	Pyridostigmine is indicated for the treatment of myasthenia gravis.[L32408] When administered intravenously, it is indicated for the reversal or antagonism of the neuromuscular blocking effects of nondepolarizing muscle relaxants.[L32413] Pyridostigmine has also been used as a prophylactic agent against irreversible organophosphorus acetylcholinesterase inhibitors, primarily in a military capacity.[L32418]	Pyridostigmine bromide, designated as 3-hydroxy-1-methyl-pyridinium bromide dimethyl-carbamate, is an orally active reversible cholinesterase inhibitor similar to [neostigmine] but with a milder adverse effect profile and a longer duration of action. Pyridostigmine may, specifically in the case of excessive administration, result in a cholinergic crisis, with symptoms mimicking a myasthenic crisis. Administration of atropine is recommended in the case of a true cholinergic crisis or to counteract muscarinic/nicotinic effects such as bradycardia and excessive bronchial secretions.[L32408, L32413]	Myasthenia gravis is an autoimmune disease involving dysfunction at the neuromuscular junction most commonly due to autoantibodies directed against the acetylcholine receptor (AChR), but also against other targets such as the muscle-specific kinase (MUSK), lipoprotein-related protein 4 (LRP4), or agrin.[A231004] In the case of AChR antibodies, AChRs are directly bound and cross-linked, impairing acetylcholine binding and contributing through various mechanisms to receptor degradation.[A231004] The lack of acetylcholine signalling leads to muscle tone loss, muscle weakness, and fatigue.[A231004] Pyridostigmine is a reversible acetylcholinesterase inhibitor that increases extracellular acetylcholine levels in the neuromuscular junction by impairing its breakdown by acetylcholinesterase.[L32408, L32413] The increased acetylcholine leads to increased neural transmission across the junction, which drastically improves myasthenia gravis symptoms.[A231004] In addition to its use in myasthenia gravis and in reversing neuromuscular blocks, pyridostigmine is also a common first-line treatment in congenital myasthenic syndromes (CMS), of which there are multiple subtypes caused by mutations in more than 30 distinct genes.[A231009, A231014] CMS present similarly to myasthenia gravis, albeit due to distinct underlying causes, and often benefit from pyridostigmine. However, in some subgroups, treatment with pyridostigmine is detrimental; detailed genetic testing is required before starting therapy.[A231009, A231014]	Pyridostigmine administered orally is poorly absorbed in the GI tract, with an oral bioavailability of only 10-20%. However, this may in part be due to some metabolism by both the blood and liver.[A231019, L32418] Approximately 1-2 hours following a single oral dose of 60 mg, the C<sub>max</sub> was determined to be 40-60 μg/L.[A231019] Pyridostigmine follows approximately linear kinetics, with a direct correlation between the dose and plasma AUC.[A231019] Pyridostigmine taken orally with food results in a flatter peak to the plasma concentration vs. time curve. The peak plasma concentrations are reached ~90 minutes later than in fasted subjects but with no change in bioavailability or AUC.[A231024]	Pyridostigmine is hydrolyzed by cholinesterases systemically, including in the blood, and by microsomal enzymes in the liver, though this remains poorly defined. The primary hydrolysis product is 3-hydroxy-N-methyl-pyridinium (HNM), which can be glucuronidated.[A231019, L32418] One study suggested the existence of as many as eight metabolites in the urine of patients receiving radiolabeled pyridostigmine intravenously, including various glucuronidated, demethylated, and oxidized (quinone) metabolites.[A231029, L32418] Another study confirmed that HNM is the main metabolite, and suggested additional possible metabolites such as a 3,4- or 3,6-dihydroxy-N-methyl-pyridinium or a methoxy- or acetoxy-N-methyl-pyridinium.[A231034] The exact products formed, apart from HNM, require further validation.	Toxicity information regarding pyridostigmine is not readily available. Patients experiencing an overdose are at an increased risk of severe adverse effects such as bradycardia, excessive bronchial secretions, and cholinergic crisis. Symptomatic and supportive measures are recommended.[L32408, L32413]	Pyridostigmine administered intravenously in healthy, myasthenic, and surgical patients has a range of elimination half-lives, between 0.38 and 1.86 hours.[A231019]	Neither pyridostigmine nor any of its detectable plasma metabolites are appreciably protein-bound.[A231019, L32418]	Pyridostigmine is primarily renally eliminated.[L32413] Roughly 90% of an intravenous dose is recovered in the urine within 24 hours, with unchanged pyridostigmine and its main metabolite HNM recovered in an approximately 4:1 ratio.[A231019, A231034, L32418]	Pyridostigmine administered intravenously in healthy, myasthenic, and surgical patients has a range of distribution volumes, between 0.53 and 1.76 L/kg.[A231019]	Pyridostigmine administered intravenously in healthy, myasthenic, and surgical patients has a range of clearance values, between 0.29 and 1.0 L/h/kg.[A231019]	Organic compounds	Organoheterocyclic compounds	Pyridines and derivatives	Methylpyridines	[ "approved", "investigational" ]	[ "N07AA", "N07A", "N07", "N" ]	[ "Humans and other mammals" ]	[ { "cost": "1.06", "description": "Mestinon-Sr 180 mg Sustained-Release Tablet", "unit": "tablet" }, { "cost": "2.46", "description": "Mestinon 60 mg tablet", "unit": "tablet" }, { "cost": "3.59", "description": "Mestinon 180 mg timespan", "unit": "each" }, { "cost": "13.64", "description": "Regonol 5 mg/ml ampul", "unit": "ml" }, { "cost": "87.6", "description": "Pyridostigmine bromide powder", "unit": "g" }, { "cost": "129.42", "description": "Mestinon 30 180 mg Controlled Release Tabs Bottle", "unit": "bottle" }, { "cost": "0.43", "description": "Mestinon 60 mg/5ml Syrup", "unit": "ml" }, { "cost": "0.48", "description": "Mestinon 60 mg Tablet", "unit": "tablet" }, { "cost": "0.6", "description": "Pyridostigmine br 60 mg tablet", "unit": "tablet" }, { "cost": "0.62", "description": "Pyridostigmine Bromide 60 mg tablet", "unit": "tablet" } ]	[ { "approved": "2018-06-18", "country": "United States", "expires": "2038-06-18", "number": "11478425" }, { "approved": "2018-06-18", "country": "United States", "expires": "2038-06-18", "number": "12042559" }, { "approved": "2018-06-18", "country": "United States", "expires": "2038-06-18", "number": "10925833" }, { "approved": "2018-06-18", "country": "United States", "expires": "2038-06-18", "number": "10987311" }, { "approved": "2018-06-18", "country": "United States", "expires": "2038-06-18", "number": "10881617" }, { "approved": "2018-06-18", "country": "United States", "expires": "2038-06-18", "number": "11666536" }, { "approved": "2018-06-18", "country": "United States", "expires": "2038-06-18", "number": "11911515" }, { "approved": "2018-06-18", "country": "United States", "expires": "2038-06-18", "number": "11229606" } ]	Piridostigmina \| Pyridostigmine cation \| 3.4.21.6 \| Stuart factor \| Stuart-Prower factor \| 3.1.1.8 \| Acylcholine acylhydrolase \| Butyrylcholine esterase \| CHE1 \| Choline esterase II \| Pseudocholinesterase \| 3.1.1.7 \| AChE \| 3.1.1.7 \| AChE \| 3.1.1.8 \| Acylcholine acylhydrolase \| Butyrylcholine esterase \| CHE1 \| Choline esterase II \| Pseudocholinesterase \| 1,4-cineole 2-exo-monooxygenase \| 1,8-cineole 2-exo-monooxygenase \| 1.14.14.1 \| Albendazole monooxygenase (sulfoxide-forming) \| Albendazole sulfoxidase \| Cholesterol 25-hydroxylase \| CYP3A3 \| CYPIIIA3 \| CYPIIIA4 \| Cytochrome P450 3A3 \| Cytochrome P450 HLp \| Cytochrome P450 NF-25 \| Cytochrome P450-PCN1 \| Nifedipine oxidase \| Quinine 3-monooxygenase	[ "Jamp Pyridostigmine Bromide", "Mestinon", "Mestinon", "Mestinon", "Mestinon", "Mestinon-SR", "Pryidostigmine Bromide", "Pryidostigmine Bromide", "Pryidostigmine Bromide", "Pryidostigmine Bromide", "Pyridostigmine", "Pyridostigmine bromide", "Pyridostigmine Bromide", "Pyridostigmine Bromide", "Pyridostigmine Bromide", "Pyridostigmine Bromide", "Pyridostigmine Bromide", "Pyridostigmine Bromide", "Pyridostigmine Bromide", "Pyridostigmine Bromide", "Pyridostigmine Bromide", "Pyridostigmine Bromide", "Pyridostigmine Bromide", "Pyridostigmine Bromide", "Pyridostigmine Bromide", "Pyridostigmine Bromide", "Pyridostigmine Bromide", "Pyridostigmine Bromide", "Pyridostigmine Bromide", "Pyridostigmine Bromide", "Pyridostigmine Bromide", "Pyridostigmine Bromide", "Pyridostigmine Bromide", "Pyridostigmine Bromide", "Pyridostigmine Bromide", "Pyridostigmine Bromide", "Pyridostigmine Bromide", "Pyridostigmine Bromide", "Pyridostigmine Bromide", "Pyridostigmine Bromide", "Pyridostigmine Bromide", "Pyridostigmine Bromide", "Pyridostigmine Bromide", "Pyridostigmine Bromide", "Pyridostigmine Bromide", "Pyridostigmine bromide", "Regonol", "Regonol Inj 5mg/ml", "Riva-pyridostigmine" ]	[ "Amiasten", "Amygra", "Antilon", "Astinon", "Kalymin", "Kalymin forte", "Kalymin N", "Kalymin retard", "Meshanon60", "Mestinon retard", "Myestin", "Pyrimine" ]	[]	[ "P00742", "P06276", "P22303" ]	[ "P22303", "P06276", "P08684" ]	[]	[]
DB00546	Adinazolam	Adinazolam (Deracyn®) is a benzodiazepine derivative with anxiolytic, anticonvulsant, sedative, and antidepressant properties. Adinazolam was first developed to enhance the antidepressant effects of [alprazolam]. It has never been approved by the FDA for clinical use.	solid	For the treatment of anxiety and status epilepticus.	Adinazolam is a benzodiazepine derivative used to treat anxiety, status epilepticus, and for sedation induction and anterograde amnesia. Adinazolam binds with high affinity to the GABA benzodiazepine receptor complex. Considerable evidence suggest that the central pharmacologic/therapeutic actions of alprazolam are mediated via interaction with this receptor complex.	Adinazolam binds to peripheral-type benzodiazepine receptors which interact allosterically with GABA receptors. This potentiates the effects of the inhibitory neurotransmitter GABA, increasing the inhibition of the ascending reticular activating system and blocking the cortical and limbic arousal that occurs following stimulation of the reticular pathways.	null	The drug primarily undergoes hepatic metabolism to form the main metabolite N-desmethyladinazolam, alpha-hydroxyalprazolam, and estazolam.	Signs of overdose may include muscle weakness, ataxia, dysarthria and particularly in children paradoxical excitement. In more severe cases diminished reflexes, confusion, and coma may ensue.	Less than 3 hours.	null	null	null	null	Organic compounds	Organoheterocyclic compounds	Benzodiazepines	1,4-benzodiazepines	[ "experimental" ]	[ "N05BA", "N05B", "N05", "N" ]	[ "Humans and other mammals" ]	[]	[]	8-Chloro-1-((dimethylamino)methyl)-6-phenyl-4H-s-triazolo(4,3-a)(1,4)benzodiazepine \| Adinazolam \| Adinazolamum \| BZRP \| MBR \| Mitochondrial benzodiazepine receptor \| PBR \| Peripheral-type benzodiazepine receptor \| PKBS \| GABA(A) receptor subunit alpha-1 \| GABAAR subunit alpha-1 \| GABA(A) receptor subunit alpha-2 \| GABAAR subunit alpha-2 \| GABA(A) receptor subunit alpha-3 \| GABAAR subunit alpha-3 \| GABA(A) receptor subunit alpha-4 \| GABAAR subunit alpha-4 \| GABA(A) receptor subunit alpha-5 \| GABAAR subunit alpha-5 \| GABA(A) receptor subunit alpha-6 \| GABAAR subunit alpha-6 \| GABA(A) receptor subunit beta-1 \| GABAAR subunit beta-1 \| GABA(A) receptor subunit beta-2 \| GABAAR subunit beta-2 \| GABA(A) receptor subunit beta-3 \| GABAAR subunit beta-3 \| GABA(A) receptor subunit delta \| GABAAR subunit delta \| GABA(A) receptor subunit epsilon \| GABAAR subunit epsilon \| GABA(A) receptor subunit gamma-1 \| GABAAR subunit gamma-1 \| GABA(A) receptor subunit gamma-2 \| GABAAR subunit gamma-2 \| GABA(A) receptor subunit gamma-3 \| GABAAR subunit gamma-3 \| GABA(A) receptor subunit pi \| GABAAR subunit pi \| GABA(A) receptor subunit theta \| GABAAR subunit theta \| GABA(A) receptor subunit alpha-1 \| GABAAR subunit alpha-1 \| GABA(A) receptor subunit alpha-2 \| GABAAR subunit alpha-2 \| GABA(A) receptor subunit alpha-3 \| GABAAR subunit alpha-3 \| GABA(A) receptor subunit alpha-5 \| GABAAR subunit alpha-5 \| GABA(A) receptor subunit gamma-1 \| GABAAR subunit gamma-1 \| GABA(A) receptor subunit gamma-2 \| GABAAR subunit gamma-2 \| GABA(A) receptor subunit gamma-3 \| GABAAR subunit gamma-3 \| 1,4-cineole 2-exo-monooxygenase \| 1,8-cineole 2-exo-monooxygenase \| 1.14.14.1 \| Albendazole monooxygenase (sulfoxide-forming) \| Albendazole sulfoxidase \| Cholesterol 25-hydroxylase \| CYP3A3 \| CYPIIIA3 \| CYPIIIA4 \| Cytochrome P450 3A3 \| Cytochrome P450 HLp \| Cytochrome P450 NF-25 \| Cytochrome P450-PCN1 \| Nifedipine oxidase \| Quinine 3-monooxygenase \| (R)-limonene 6-monooxygenase \| (S)-limonene 6-monooxygenase \| (S)-limonene 7-monooxygenase \| 1.14.14.1 \| CYPIIC17 \| CYPIIC19 \| Cytochrome P450-11A \| Cytochrome P450-254C \| Fenbendazole monooxygenase (4'-hydroxylating) \| Mephenytoin 4-hydroxylase	[]	[ "Deracyn" ]	[]	[ "P30536", "P14867", "P47869", "P34903", "P48169", "P31644", "Q16445", "P18505", "P47870", "P28472", "O14764", "P78334", "Q8N1C3", "P18507", "Q99928", "O00591", "Q9UN88", "P14867", "P47869", "P34903", "P31644", "Q8N1C3", "P18507", "Q99928" ]	[ "P08684", "P33261" ]	[]	[]
DB00547	Desoximetasone	A topical anti-inflammatory glucocorticoid used in dermatoses, skin allergies, psoriasis, etc.	solid	For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.	Like other topical corticosteroids, desoximetasone has anti-inflammatory, antipruritic, and vasoconstrictive properties. Once absorbed through the skin, topical corticosteroids are handled through pharmacokinetic pathways similar to systemically administered corticosteroids. Desoximetasone is a potent topical corticosteroid that should not be used with occlusive dressings. It is recommended that treatment should be limited to 2 consecutive weeks and therapy should be discontinued when adequate results have been achieved.	The precise mechanism of the antiinflammatory activity of topical steroids in the treatment of steroid-responsive dermatoses, in general, is uncertain. However, corticosteroids are thought to act by the induction of phospholipase A<sub>2</sub> inhibitory proteins, collectively called lipocortins. This is achieved first by the drug binding to the glucocorticoid receptors which then translocates into the nucleus and binds to DNA causing various activations and repressions of genes. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A<sub>2</sub>.	Topical corticosteroids can be absorbed from intact healthy skin. The extent of percutaneous absorption of topical corticosteroids is determined by many factors, including the vehicle and the integrity of the epidermal barrier. Occlusion, inflammation and/or other disease processes in the skin may also increase percutaneous absorption.	Metabolized, primarily in the liver, and then excreted by the kidneys.	Topically applied desoximetasone can be absorbed in sufficient amounts to produce systemic effects. Symptoms of overdose include thinning of skin and suppression of adrenal cortex (decreased ability to respond to stress).	The half-life of the material was 15 ± 2 hours (for urine) and 17 ± 2 hours (for feces) between the third and fifth trial day.	Bound to plasma proteins in varying degrees.	Corticosteroids are bound to plasma proteins in varying degrees, are metabolized primarily in the liver and excreted by the kidneys. Some of the topical corticosteroids and their metabolites are also excreted into the bile.Pharmacokinetic studies in men with Desoximetasone Cream USP, 0.25% with tagged desoximetasone showed a total of 5.2% ± 2.9% excretion in urine (4.1% ± 2.3%) and feces (1.1% ± 0.6%)	null	null	Organic compounds	Lipids and lipid-like molecules	Steroids and steroid derivatives	Hydroxysteroids	[ "approved" ]	[ "D07AC", "D07A", "D07", "D", "D07XC", "D07X", "D07", "D" ]	[ "Humans and other mammals" ]	[ { "cost": "1.29", "description": "Desoximetasone 0.05% cream", "unit": "g" }, { "cost": "3.45", "description": "Topicort lp 0.05% cream", "unit": "g" }, { "cost": "4.32", "description": "Topicort 0.25% cream", "unit": "g" }, { "cost": "51.25", "description": "Desoximetasone 0.05% Cream 15 gm Tube", "unit": "tube" }, { "cost": "54.46", "description": "Desoximetasone 0.05% Gel 15 gm Tube", "unit": "tube" }, { "cost": "59.94", "description": "Desoximetasone 0.25% Cream 15 gm Tube", "unit": "tube" }, { "cost": "64.99", "description": "Topicort 0.25% Cream 15 gm Tube", "unit": "tube" }, { "cost": "68.86", "description": "Desoximetasone 0.25% Ointment 15 gm Tube", "unit": "tube" }, { "cost": "74.59", "description": "Topicort 0.05% Gel 15 gm Tube", "unit": "tube" }, { "cost": "94.14", "description": "Topicort 0.25% Ointment 15 gm Tube", "unit": "tube" }, { "cost": "174.86", "description": "Desoximetasone 0.05% Gel 60 gm Tube", "unit": "tube" }, { "cost": "189.99", "description": "Desoximetasone 0.05% Cream 60 gm Tube", "unit": "tube" }, { "cost": "204.91", "description": "Desoximetasone 0.25% Cream 60 gm Tube", "unit": "tube" }, { "cost": "229.01", "description": "Desoximetasone 0.25% Ointment 60 gm Tube", "unit": "tube" }, { "cost": "230.24", "description": "Topicort 0.25% Cream 60 gm Tube", "unit": "tube" }, { "cost": "312.62", "description": "Topicort 0.25% Ointment 60 gm Tube", "unit": "tube" }, { "cost": "0.5", "description": "Topicort Mild 0.05 % Cream", "unit": "g" }, { "cost": "0.63", "description": "Desoximetasone 0.25% cream", "unit": "g" }, { "cost": "0.73", "description": "Topicort 0.25 % Cream", "unit": "g" } ]	[ { "approved": "1999-11-23", "country": "United States", "expires": "2018-03-24", "number": "5990100" }, { "approved": "2014-05-06", "country": "United States", "expires": "2026-05-26", "number": "8715624" }, { "approved": "2012-10-02", "country": "United States", "expires": "2028-09-01", "number": "8277780" } ]	(11β,16α)-9-fluoro-11,21-dihydroxy-16-methylpregna-1,4-diene-3,20-dione \| 9alpha-fluoro-16alpha-methyl-delta(1)-corticosterone \| Deoxymethasone \| Desoximetason \| Desoximetasona \| Désoximétasone \| Desoximetasone \| Desoximetasonum \| Desoxymethasone \| ERR gamma-2 \| ERR3 \| ERRG2 \| Estrogen receptor-related protein 3 \| KIAA0832 \| NR3B3 \| Nuclear receptor subfamily 3 group B member 3 \| GR \| GRL \| Nuclear receptor subfamily 3 group C member 1 \| ERR beta-2 \| ERR-beta \| ERRB2 \| ESRL2 \| Estrogen receptor-like 2 \| Estrogen-related receptor beta \| NR3B2 \| Nuclear receptor subfamily 3 group B member 2 \| ERR-alpha \| ERR1 \| ESRL1 \| Estrogen receptor-like 1 \| Estrogen-related receptor alpha \| NR3B1 \| Nuclear receptor subfamily 3 group B member 1	[ "Desoxi Cream 0.05%", "Desoxi Cream 0.25%", "Desoxi Gel 0.05%", "Desoximetasone", "Desoximetasone", "Desoximetasone", "Desoximetasone", "Desoximetasone", "Desoximetasone", "Desoximetasone", "Desoximetasone", "Desoximetasone", "Desoximetasone", "Desoximetasone", "Desoximetasone", "Desoximetasone", "Desoximetasone", "Desoximetasone", "Desoximetasone", "Desoximetasone", "Desoximetasone", "Desoximetasone", "Desoximetasone", "Desoximetasone", "Desoximetasone", "Desoximetasone", "Desoximetasone", "Desoximetasone", "Desoximetasone", "Desoximetasone", "Desoximetasone", "Desoximetasone", "Desoximetasone", "Desoximetasone", "Desoximetasone", "Desoximetasone", "Desoximetasone", "Desoximetasone", "Desoximetasone", "Desoximetasone", "Desoximetasone", "Desoximetasone", "Desoximetasone", "Desoximetasone", "Desoximetasone", "Desoximetasone", "Desoximetasone", "Desoximetasone", "Desoximetasone", "Desoximetasone", "Desoximetasone", "Desoximetasone", "Desoximetasone", "Desoximetasone", "Desoximetasone", "Desoximetasone", "Desoximetasone", "Desoximetasone", "Desoximetasone", "Desoximetasone", "Desoximetasone", "Desoximetasone", "Desoximetasone 0.05% / Hydroquinone 6% / Tretinoin 0.05%", "Desoximetasone 0.05% / Niacinamide 4%", "Desoximetasone 0.05% / Niacinamide 4%", "Desoximetasone 0.05% / Niacinamide 4%", "Desoximetasone Oint 0.05%", "Desoximetasone Oint 0.05%", "Topicort", "Topicort", "Topicort", "Topicort", "Topicort", "Topicort", "Topicort", "Topicort", "Topicort", "Topicort", "Topicort", "Topicort", "Topicort 0.25%", "Topicort Crm 2.5mg/gm", "Topicort Gel 0.05%", "Topicort Gel 0.05%", "Topicort Mild .05%", "Topicort Mild Cream 0.5mg/gm", "Topicort Ointment 2.5mg/gm" ]	[ "Esperson", "Flubason", "Topicort LP", "Topisolon" ]	[ "Desoximetasone 0.05% / Niacinamide 4%", "Desoximetasone 0.05% / Niacinamide 4%", "Desoximetasone 0.05% / Hydroquinone 6% / Tretinoin 0.05%", "Desoximetasone 0.05% / Niacinamide 4%" ]	[ "P62508", "P04150", "O95718", "P11474" ]	[]	[]	[]
DB00548	Azelaic acid	Azelaic acid is a saturated dicarboxylic acid found naturally in wheat, rye, and barley. It is also produced by _Malassezia furfur_, also known as _Pityrosporum ovale_, which is a species of fungus that is normally found on human skin. Azelaic acid is effective against a number of skin conditions, such as mild to moderate acne, when applied topically in a cream formulation of 20%. It works in part by stopping the growth of skin bacteria that cause acne, and by keeping skin pores clear. Azelaic acid's antimicrobial action may be attributable to inhibition of microbial cellular protein synthesis.	solid	For the topical treatment of mild-to-moderate inflammatory acne vulgaris.	Azelaic acid is a saturated dicarboxylic acid found naturally in wheat, rye, and barley. It is a natural substance that is produced by <i>Malassezia furfur</i> (also known as <i>Pityrosporum ovale</i>), a yeast that lives on normal skin. It is effective against a number of skin conditions, such as mild to moderate acne, when applied topically in a cream formulation of 20%. It works in part by stopping the growth of skin bacteria that cause acne, and by keeping skin pores clear. Azelaic acid's antimicrobial action may be attributable to inhibition of microbial cellular protein synthesis.	The exact mechanism of action of azelaic acid is not known. It is thought that azelaic acid manifests its antibacterial effects by inhibiting the synthesis of cellular protein in anaerobic and aerobic bacteria, especially <i>Staphylococcus epidermidis</i> and <i>Propionibacterium acnes</i>. In aerobic bacteria, azelaic acid reversibly inhibits several oxidoreductive enzymes including tyrosinase, mitochondrial enzymes of the respiratory chain, thioredoxin reductase, 5-alpha-reductase, and DNA polymerases. In anaerobic bacteria, azelaic acid impedes glycolysis. Along with these actions, azelaic acid also improves acne vulgaris by normalizing the keratin process and decreasing microcomedo formation. Azelaic acid may be effective against both inflamed and noninflamed lesions. Specifically, azelaic acid reduces the thickness of the stratum corneum, shrinks keratohyalin granules by reducing the amount and distribution of filaggrin (a component of keratohyalin) in epidermal layers, and lowers the number of keratohyalin granules.	Approximately 4% of the topically applied azelaic acid is systemically absorbed.	Mainly excreted unchanged in the urine but undergoes some b-oxidation to shorter chain dicarboxylic acids.	Oral LD50 in rat: >5 g/kg	The observed half-lives in healthy subjects are approximately 45 minutes after oral dosing and 12 hours after topical dosing, indicating percutaneous absorption rate-limited kinetics.	null	Azelaic acid is mainly excreted unchanged in the urine, but undergoes some ß-oxidation to shorter chain dicarboxylic acids.	null	null	Organic compounds	Lipids and lipid-like molecules	Fatty Acyls	Fatty acids and conjugates	[ "approved" ]	[ "D10AX", "D10A", "D10", "D" ]	[ "Various aerobic and anaerobic microorganisms" ]	[ { "cost": "1.05", "description": "Azelaic acid flakes", "unit": "g" }, { "cost": "2.86", "description": "Finacea 15% gel", "unit": "g" }, { "cost": "5.21", "description": "Azelex 20% cream", "unit": "g" }, { "cost": "143.15", "description": "Finacea plus kit", "unit": "kit" }, { "cost": "162.28", "description": "Finacea 15% Gel 50 gm Tube", "unit": "tube" }, { "cost": "181.32", "description": "Azelex 20% Cream 30 gm Tube", "unit": "tube" }, { "cost": "262.74", "description": "Azelex 20% Cream 50 gm Tube", "unit": "tube" } ]	[ { "approved": "2008-01-29", "country": "Canada", "expires": "2018-11-18", "number": "2311128" }, { "approved": "2004-05-04", "country": "United States", "expires": "2019-09-08", "number": "6730288" }, { "approved": "2003-03-18", "country": "United States", "expires": "2018-11-18", "number": "6534070" }, { "approved": "2015-12-15", "country": "United States", "expires": "2029-01-26", "number": "9211259" }, { "approved": "2013-05-07", "country": "United States", "expires": "2024-03-01", "number": "8435498" }, { "approved": "2016-02-23", "country": "United States", "expires": "2027-12-08", "number": "9265725" }, { "approved": "2014-12-02", "country": "United States", "expires": "2023-10-24", "number": "8900554" }, { "approved": "2014-05-13", "country": "United States", "expires": "2023-10-24", "number": "8722021" }, { "approved": "2010-04-20", "country": "United States", "expires": "2027-09-18", "number": "7700076" }, { "approved": "2018-11-06", "country": "United States", "expires": "2027-10-18", "number": "10117812" }, { "approved": "2019-06-18", "country": "United States", "expires": "2023-10-24", "number": "10322085" } ]	1,7-dicarboxyheptane \| 1,7-Heptanedicarboxylic acid \| 1,9-nonanedioic acid \| Acide azélaïque \| Ácido azelaico \| Acidum acelaicum \| Acidum azelaicum \| Anchoic acid \| Azelaic acid \| Azelainsäure \| Lepargylic acid \| n-nonanedioic acid \| Nonandisäure \| Nonanedioic acid \| 1.8.1.9 \| TRXR \| 1.3.1.94 \| 3-oxo-5-alpha-steroid 4-dehydrogenase 3 \| S5AR 3 \| SR type 3 \| SRD5A2L \| Steroid 5-alpha-reductase 2-like \| Steroid 5-alpha-reductase 3 \| 1.3.1.22 \| S5AR 1 \| SR type 1 \| Steroid 5-alpha-reductase 1 \| 1.3.1.3 \| 3-oxo-5-beta-steroid 4-dehydrogenase \| Delta(4)-3-ketosteroid 5-beta-reductase \| Delta(4)-3-oxosteroid 5-beta-reductase \| SRD5B1 \| 1.3.1.22 \| 5 alpha-SR2 \| S5AR 2 \| SR type 2 \| Steroid 5-alpha-reductase 2 \| Type II 5-alpha reductase \| 1.14.18.1 \| LB24-AB \| Monophenol monooxygenase \| SK29-AB \| Tumor rejection antigen AB \| 2.7.7.7 \| POL I \| resA	[ "2% Salicylic Acid FACIAL CLEANSER", "AnubisMed", "Azelaic Acid", "Azelaic Acid", "Azelaic Acid", "Azelaic Acid", "Azelaic Acid", "Azelaic Acid 15% / Niacinamide 4%", "Azelaic Acid Gel", "Azelaic Acid Gel", "Azelaic Acid Gel", "Azelex", "Azelex", "Azelex", "ELCURE AC-LEX Serum", "Finacea", "Finacea", "Finacea", "Finacea", "Finacea", "Finacea", "Finacea", "Finacea", "Finacea Foam", "Finacea Foam", "NicAzel", "Tri-Zel", "Vp-zel", "Vp-zel" ]	[ "Acne-Derm", "Acnean", "Acnederm", "Acnesafe", "Aknoren", "Ami", "Arbonid", "Finevin", "Skinoren", "Zumilin" ]	[ "Tri-Zel", "Vp-zel", "Azelaic Acid 15% / Niacinamide 4%", "NicAzel", "Vp-zel", "AnubisMed", "2% Salicylic Acid FACIAL CLEANSER" ]	[ "Q9H8P0", "P18405", "P51857", "P31213", "P14679" ]	[]	[]	[]
DB00549	Zafirlukast	Zafirlukast is an oral leukotriene receptor antagonist (LTRA) for the maintenance treatment of asthma, often used in conjunction with an inhaled steroid and/or long-acting bronchodilator. It is available as a tablet and is usually dosed twice daily. Another leukotriene receptor antagonist is montelukast (Singulair), which is usually taken just once daily. Zafirlukast blocks the action of the cysteinyl leukotrienes on the CysLT1 receptors, thus reducing constriction of the airways, build-up of mucus in the lungs and inflammation of the breathing passages.	solid	For the prophylaxis and chronic treatment of asthma.	Zafirlukast is a synthetic, selective peptide leukotriene receptor antagonist (LTRA) indicated for the prophylaxis and chronic treatment of asthma. Patients with asthma were found in one study to be 25-100 times more sensitive to the bronchoconstricting activity of inhaled LTD<sub>4</sub> than nonasthmatic subjects. <i>In vitro</i> studies demonstrated that zafirlukast antagonized the contractile activity of three leukotrienes (LTC<sub>4</sub>, LTD<sub>4</sub> and LTE<sub>4</sub>) in conducting airway smooth muscle from laboratory animals and humans. Zafirlukast prevented intradermal LTD<sub>4</sub>-induced increases in cutaneous vascular permeability and inhibited inhaled LTD<sub>4</sub>-induced influx of eosinophils into animal lungs.	Zafirlukast is a selective and competitive receptor antagonist of leukotriene D4 and E4 (LTD<sub>4</sub> and LTE4), components of slow-reacting substance of anaphylaxis (SRSA). Cysteinyl leukotriene production and receptor occupation have been correlated with the pathophysiology of asthma, including airway edema, smooth muscle constriction, and altered cellular activity associated with the inflammatory process, which contribute to the signs and symptoms of asthma.	Rapidly absorbed following oral administration, reduced following a high-fat or high-protein meal.	Hepatic	Side effects include rash and upset stomach.	10 hours	99%	The most common metabolic products are hydroxylated metabolites which are excreted in the feces.	* 70 L	* apparent oral CL=20 L/h * 11.4 L/h [7-11 yrs] * 9.2 L/h [5-6 yrs]	Organic compounds	Benzenoids	Benzene and substituted derivatives	Benzenesulfonamides	[ "approved", "investigational" ]	[ "R03DC", "R03D", "R03", "R" ]	[ "Humans and other mammals" ]	[ { "cost": "1.86", "description": "Accolate 20 mg tablet", "unit": "tablet" }, { "cost": "1.92", "description": "Accolate 10 mg tablet", "unit": "tablet" } ]	[ { "approved": "1997-03-18", "country": "United States", "expires": "2014-03-18", "number": "5612367" }, { "approved": "1989-08-22", "country": "United States", "expires": "2010-09-26", "number": "4859692" }, { "approved": "2002-04-02", "country": "Canada", "expires": "2011-11-22", "number": "2056066" }, { "approved": "1999-06-01", "country": "Canada", "expires": "2016-06-01", "number": "1340567" } ]	4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol-3-ylmethyl)-3-methoxy-N-o-tolylsulfonylbenzamide \| cyclopentyl 3-(2-methoxy-4-((o-tolylsulfonyl)carbamoyl)benzyl)-1-methylindole-5-carbamate \| Zafirlukast \| CYSLT1 \| CysLTR1 \| Cysteinyl leukotriene D4 receptor \| G-protein coupled receptor HG55 \| HMTMF81 \| LTD4 receptor \| (R)-limonene 6-monooxygenase \| (S)-limonene 6-monooxygenase \| (S)-limonene 7-monooxygenase \| 1.14.14.1 \| Cholesterol 25-hydroxylase \| CYP2C10 \| CYPIIC9 \| Cytochrome P-450MP \| Cytochrome P450 MP-4 \| Cytochrome P450 MP-8 \| Cytochrome P450 PB-1 \| S-mephenytoin 4-hydroxylase \| 1.14.14.1 \| CYPIIC8 \| Cytochrome P450 form 1 \| Cytochrome P450 IIC2 \| Cytochrome P450 MP-12 \| Cytochrome P450 MP-20 \| S-mephenytoin 4-hydroxylase \| 1.14.99.1 \| COX-1 \| COX1 \| Cyclooxygenase-1 \| PGH synthase 1 \| PGHS-1 \| PHS 1 \| Prostaglandin H2 synthase 1 \| Prostaglandin-endoperoxide synthase 1 \| 1,4-cineole 2-exo-monooxygenase \| 1,8-cineole 2-exo-monooxygenase \| 1.14.14.1 \| Albendazole monooxygenase (sulfoxide-forming) \| Albendazole sulfoxidase \| Cholesterol 25-hydroxylase \| CYP3A3 \| CYPIIIA3 \| CYPIIIA4 \| Cytochrome P450 3A3 \| Cytochrome P450 HLp \| Cytochrome P450 NF-25 \| Cytochrome P450-PCN1 \| Nifedipine oxidase \| Quinine 3-monooxygenase \| 1.14.14.1 \| Cholesterol 25-hydroxylase \| CYPIA2 \| Cytochrome P(3)450 \| Cytochrome P450 4 \| Cytochrome P450-P3 \| Hydroperoxy icosatetraenoate dehydratase \| (R)-limonene 6-monooxygenase \| (S)-limonene 6-monooxygenase \| (S)-limonene 7-monooxygenase \| 1.14.14.1 \| CYPIIC17 \| CYPIIC19 \| Cytochrome P450-11A \| Cytochrome P450-254C \| Fenbendazole monooxygenase (4'-hydroxylating) \| Mephenytoin 4-hydroxylase \| 1.14.14.- \| Cholesterol 25-hydroxylase \| CYP2DL1 \| CYPIID6 \| Cytochrome P450-DB1 \| Debrisoquine 4-hydroxylase \| 7.6.2.2 \| ABCP \| ATP-binding cassette sub-family G member 2 \| BCRP \| BCRP1 \| Breast cancer resistance protein \| CDw338 \| Mitoxantrone resistance-associated protein \| MXR \| Placenta-specific ATP-binding cassette transporter \| Urate exporter \| Cell growth-inhibiting gene 29 protein \| Na(+)/bile acid cotransporter \| Na(+)/taurocholate transport protein \| NTCP \| SLC10A1 \| Sodium/taurocholate cotransporting polypeptide \| Solute carrier family 10 member 1	[ "Accolate", "Accolate", "Accolate", "Accolate", "Accolate", "Accolate", "Accolate", "Accolate", "Accolate", "Accolate", "Accolate Tab 20 mg", "Zafirlukast", "Zafirlukast", "Zafirlukast", "Zafirlukast", "Zafirlukast", "Zafirlukast", "Zafirlukast", "Zafirlukast", "Zafirlukast", "Zafirlukast", "Zafirlukast", "Zafirlukast", "Zafirlukast", "Zafirlukast", "Zafirlukast", "Zafirlukast", "Zafirlukast", "Zafirlukast", "Zafirlukast", "Zafirlukast", "Zafirlukast", "Zafirlukast", "Zafirlukast", "Zafirlukast", "Zafirlukast", "Zafirlukast" ]	[]	[]	[ "Q9Y271" ]	[ "P11712", "P10632", "P23219", "P08684", "P05177", "P33261", "P10635" ]	[]	[ "Q9UNQ0", "Q14973" ]
DB00550	Propylthiouracil	A thiourea antithyroid agent. Propythiouracil inhibits the synthesis of thyroxine and inhibits the peripheral conversion of throxine to tri-iodothyronine. It is used in the treatment of hyperthyroidism. (From Martindale, The Extra Pharmacopeoia, 30th ed, p534)	solid	Used to manage hyperthyroidism which is due to an overactive thyroid gland (Grave's disease).	Propylthiouracil is a thiourea antithyroid agent. Grave's disease is the most common cause of hyperthyroidism. It is an autoimmune disease where an individual's own antibodies attach to thyroid stimulating hormone receptors within cells of the thyroid gland and then trigger overproduction of thyroid hormone. The two thyroid hormones manufactured by the thyroid gland, thyroxine (T4) and triiodothyronine (T3), are formed by combining iodine and a protein called thyroglobulin with the assistance of an enzyme called peroxidase. PTU inhibits iodine and peroxidase from their normal interactions with thyroglobulin to form T4 and T3. This action decreases thyroid hormone production. PTU also interferes with the conversion of T4 to T3, and, since T3 is more potent than T4, this also reduces the activity of thyroid hormones. The actions and use of propylthiouracil are similar to those of methimazole.	Propylthiouracil binds to thyroid peroxidase and thereby inhibits the conversion of iodide to iodine. Thyroid peroxidase normally converts iodide to iodine (via hydrogen peroxide as a cofactor) and also catalyzes the incorporation of the resulting iodide molecule onto both the 3 and/or 5 positions of the phenol rings of tyrosines found in thyroglobulin. Thyroglobulin is degraded to produce thyroxine (T4) and tri-iodothyronine (T3), which are the main hormones produced by the thyroid gland. Therefore propylthiouracil effectively inhibits the production of new thyroid hormones.	Well absorbed following oral administration.	null	Oral, rat: LD<sub>50</sub> = 1250 mg/kg.	2 hours	82%	Propylthiouracil is readily absorbed and is extensively metabolized. Approximately 35% of the drug is excreted in the urine, in intact and conjugated forms, within 24 hours.	null	null	Organic compounds	Organoheterocyclic compounds	Diazines	Pyrimidines and pyrimidine derivatives	[ "approved", "investigational" ]	[ "H03BA", "H03B", "H03", "H" ]	[ "Humans and other mammals" ]	[ { "cost": "0.18", "description": "Propylthiouracil 50 mg tablet", "unit": "tablet" }, { "cost": "0.22", "description": "Propyl-Thyracil 50 mg Tablet", "unit": "tablet" }, { "cost": "0.34", "description": "Propyl-Thyracil 100 mg Tablet", "unit": "tablet" } ]	[]	2-Mercapto-6-propyl-4-pyrimidone \| 2-Mercapto-6-propylpyrimid-4-one \| 2-Thio-4-oxo-6-propyl-1,3-pyrimidine \| 2-Thio-6-propyl-1,3-pyrimidin-4-one \| 4-propyl-2-thiouracil \| 6-Propyl-2-thio-2,4(1H,3H)pyrimidinedione \| 6-propyl-2-thiouracil \| 6-propyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one \| 6-Propylthiouracil \| 6-Thio-4-propyluracil \| Propiltiouracilo \| Propylthiouracil \| Propylthiouracile \| Propylthiouracilum \| 1.21.99.4 \| 5DI \| DIOI \| ITDI1 \| TXDI1 \| Type 1 DI \| Type-I 5'-deiodinase \| 1.11.1.8 \| TPO \| 1.11.2.2 \| MPO \| 1.14.17.1 \| Dopamine beta-monooxygenase \| 1.14.14.1 \| CYPIA1 \| Cytochrome P450 form 6 \| Cytochrome P450-C \| Cytochrome P450-P1 \| Hydroperoxy icosatetraenoate dehydratase	[ "Apo-propylthiouracil", "Apo-propylthiouracil", "Halycil", "PMS-propylthiouracil", "PMS-propylthiouracil", "Propyl-thyracil", "Propyl-thyracil", "Propylthiouracil", "Propylthiouracil", "Propylthiouracil", "Propylthiouracil", "Propylthiouracil", "Propylthiouracil", "Propylthiouracil", "Propylthiouracil", "Propylthiouracil", "Propylthiouracil", "Propylthiouracil", "Propylthiouracil", "Propylthiouracil", "Propylthiouracil", "Propylthiouracil", "Propylthiouracil", "Propylthiouracil", "Propylthiouracil", "Propylthiouracil", "Propylthiouracil Tablets" ]	[ "Antiroid", "Propil", "Propilracil", "Propycil", "Proracyl", "Prothiucil", "Prothuril", "PTU", "Thiuragyl", "Thyrosan", "Tiotil", "Tirostat", "Uracil" ]	[]	[ "P49895", "P07202" ]	[ "P05164", "P09172", "P04798" ]	[]	[]
DB00551	Acetohydroxamic acid	Acetohydroxamic Acid, a synthetic drug derived from hydroxylamine and ethyl acetate, is similar in structure to urea. In the urine, it acts as an antagonist of the bacterial enzyme urease. Acetohydroxamic Acid has no direct antimicrobial action and does not acidify urine directly. It is used, in addition to antibiotics or medical procedures, to treat chronic urea-splitting urinary infections.	solid	Used, in addition to antibiotics or medical procedures, to treat chronic urea-splitting urinary infections.	Acetohydroxamic Acid, a synthetic drug derived from hydroxylamine and ethyl acetate, is similar in structure to urea. In the urine, it acts as an antagonist of the bacterial enzyme urease. Acetohydroxamic Acid has no direct antimicrobial action and does not acidify urine directly.	Acetohydroxamic Acid reversibly inhibits the bacterial enzyme urease. This inhibits the hydrolysis of urea and production of ammonia in urine infected with urea-splitting organisms, leading to a decrease in pH and ammonia levels. As antimicrobial agents are more effective in such conditions, the effectiveness of these agents is amplified, resulting in a higher cure rate.	Well absorbed from the GI tract following oral administration.	35-65% of oral dose excreted unchanged in urine (which provides the drug's therapeutic effect).	Oral, rat: LD<sub>50</sub> = 4.8gm/kg. Symptoms of overdose include anorexia, malaise, lethargy, diminished sense of wellbeing, tremor, anxiety, nausea, and vomiting.	5-10 hours in patients with normal renal function	No known binding	null	null	null	Organic compounds	Organic acids and derivatives	Carboxylic acids and derivatives	Carboxylic acid derivatives	[ "approved" ]	[ "G04BX", "G04B", "G04", "G" ]	[ "Enteric bacteria and other eubacteria" ]	[ { "cost": "1.66", "description": "Lithostat 250 mg tablet", "unit": "tablet" } ]	[]	Acethydroxamsaeure \| Acetic acid, oxime \| Acetohydroxamate \| Acetohydroxamic acid \| Acetohydroximic acid \| Acetyl hydroxyamino \| Acetylhydroxamic acid \| Acide acetohydroxamique \| Acido acetohidroxamico \| Acidum acetohydroxamicum \| AHA \| Cetohyroxamic acid \| Methylhydroxamic acid \| N-Acetyl hydroxyacetamide \| N-Acetylhydroxylamine \| N-Hydroxyacetamide \| 3.5.1.5 \| Urea amidohydrolase subunit alpha \| 3.4.24.65 \| HME \| Macrophage elastase \| Matrix metalloproteinase-12 \| ME \| MME \| MMP-12	[ "Lithostat" ]	[]	[]	[ "P39900" ]	[]	[]	[]
DB00552	Pentostatin	A potent inhibitor of adenosine deaminase. The drug is effective in the treatment of many lymphoproliferative malignancies, particularly hairy-cell leukemia. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity.	solid	For the treatment of hairy cell leukaemia refractory to alpha interferon.	Pentostatin is an antineoplastic anti-metabolite used in the treatment of several forms of leukemia including acute nonlymphocytic leukemia and hairy cell leukemia. Anti-metabolites masquerade as purine or pyrimidine - which become the building blocks of DNA. They prevent these substances becoming incorporated in to DNA during the "S" phase (of the cell cycle), stopping normal development and division. It is a 6-thiopurine analogue of the naturally occurring purine bases hypoxanthine and guanine. Intracellular activation results in incorporation into DNA as a false purine base. An additional cytotoxic effect is related to its incorporation into RNA. Cytotoxicity is cell cycle phase-specific (S-phase).	Pentostatin is a potent transition state inhibitor of adenosine deaminase (ADA), the greatest activity of which is found in cells of the lymphoid system. T-cells have higher ADA activity than B-cells, and T-cell malignancies have higher activity than B-cell malignancies. The cytotoxicity that results from prevention of catabolism of adenosine or deoxyadenosine is thought to be due to elevated intracellular levels of dATP, which can block DNA synthesis through inhibition of ribonucleotide reductase. Intracellular activation results in incorporation into DNA as a false purine base. An additional cytotoxic effect is related to its incorporation into RNA. Cytotoxicity is cell cycle phase-specific (S-phase).	Not absorbed orally, crosses blood brain barrier.	Primarily hepatic, but only small amounts are metabolized.	LD<sub>50</sub>=128 mg/kg (mouse), side effects include lethargy, rash, fatigue, nausea and myelosuppression.	5.7 hours (with a range between 2.6 and 16 hrs)	4%	In man, following a single dose of 4 mg/m2 of pentostatin infused over 5 minutes, approximately 90% of the dose was excreted in the urine as unchanged pentostatin and/or metabolites as measured by adenosine deaminase inhibitory activity.	null	* 68 mL/min/m2	Organic compounds	Organoheterocyclic compounds	Imidazodiazepines	null	[ "approved", "investigational" ]	[ "L01XX", "L01X", "L01", "L" ]	[ "Humans and other mammals", "Staphylococcus aureus", "Escherichia coli", "Klebsiella", "Salmonella typhi", "Shigella", "Proteus vulgaris", "Serratia marcescens", "Vibrio cholerae", "Borrelia burgdorferi", "Leptospira interrogans", "Mycobacterium tuberculosis", "Pseudomonas aeruginosa" ]	[ { "cost": "1891.31", "description": "Nipent 10 mg vial", "unit": "vial" }, { "cost": "2280.0", "description": "Pentostatin 10 mg vial", "unit": "vial" } ]	[]	Co-vidarabine \| Pentostatin \| Pentostatina \| Pentostatine \| Pentostatinum \| 3.5.4.4 \| ADA1 \| Adenosine aminohydrolase	[ "Nipent", "Nipent Pws 10mg/vial", "Pentostatin", "Pentostatin" ]	[]	[]	[ "P00813" ]	[]	[]	[]
DB00553	Methoxsalen	A naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia. It is a photoactive substance that forms DNA adducts in the presence of ultraviolet A irradiation.	solid	For the treatment of psoriasis and vitiligo	Methoxsalen selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The guanine and cytosine content correlates with the degree of Methoxsalen-induced cross-linking. At high concentrations of the drug, cellular RNA and protein synthesis are also suppressed.	After activation it binds preferentially to the guanine and cytosine moieties of DNA, leading to cross-linking of DNA, thus inhibiting DNA synthesis and function.	null	null	null	Approximately 2 hours	null	In both mice and man, methoxsalen is rapidly metabolized. Approximately 95% of the drug is excreted as a series of metabolites in the urine within 24 hours (Pathak et al. 1977).	null	null	Organic compounds	Phenylpropanoids and polyketides	Coumarins and derivatives	Furanocoumarins	[ "approved" ]	[ "D05BA", "D05B", "D05", "D", "D05AD", "D05A", "D05", "D" ]	[ "Humans and other mammals" ]	[ { "cost": "1.65", "description": "Oxsoralen 10 mg/ml Lotion", "unit": "g" }, { "cost": "9.5", "description": "Uvadex 20 mcg/ml vial", "unit": "ml" }, { "cost": "18.65", "description": "Oxsoralen Ultra 10 mg Capsule", "unit": "capsule" }, { "cost": "18.86", "description": "Oxsoralen 1% lotion", "unit": "ml" }, { "cost": "35.4", "description": "8-mop 10 mg capsule", "unit": "capsule" }, { "cost": "35.4", "description": "Oxsoralen-ultra 10 mg capsule", "unit": "capsule" }, { "cost": "242.2", "description": "Methoxsalen crystal", "unit": "g" }, { "cost": "0.65", "description": "Oxsoralen 10 mg Capsule", "unit": "capsule" } ]	[]	6-hydroxy-7-methoxy-5-benzofuranacrylic acid δ-lactone \| 8-methoxy-[furano-3'.2':6.7-coumarin] \| 8-methoxy-2',3',6,7-furocoumarin \| 8-methoxy-4',5':6,7-furocoumarin \| 8-Methoxyfuranocoumarin \| 8-methoxypsoralen \| 8-MOP \| 8-MP \| 9-methoxy-7H-furo[3,2-g][1]benzopyran-7-one \| Ammoidin \| Methoxsalen \| Méthoxsalène \| Metoxaleno \| O-methylxanthotoxol \| Xanthotoxin \| Xanthotoxine \| 1,4-cineole 2-exo-monooxygenase \| 1.14.14.- \| Coumarin 7-hydroxylase \| CYP2A3 \| CYPIIA6 \| Cytochrome P450 IIA3 \| Cytochrome P450(I) \| 1.14.14.1 \| CYPIA1 \| Cytochrome P450 form 6 \| Cytochrome P450-C \| Cytochrome P450-P1 \| Hydroperoxy icosatetraenoate dehydratase \| 1.14.14.1 \| CYPIIA13 \| 1,4-cineole 2-exo-monooxygenase \| 1.14.14.- \| Coumarin 7-hydroxylase \| CYP2A3 \| CYPIIA6 \| Cytochrome P450 IIA3 \| Cytochrome P450(I) \| 1.14.14.1 \| Cholesterol 25-hydroxylase \| CYPIA2 \| Cytochrome P(3)450 \| Cytochrome P450 4 \| Cytochrome P450-P3 \| Hydroperoxy icosatetraenoate dehydratase	[ "8-mop", "Methoxsalen", "Methoxsalen", "Methoxsalen", "Oxsoralen", "Oxsoralen Cap 10mg", "Oxsoralen Lot 10mg/ml", "Oxsoralen-Ultra", "Oxsoralen-ultra Cap 10mg", "Ultra Mop Lotion 1%", "Ultramop Cap 10mg", "Uvadex", "Uvadex" ]	[ "Deltasoralen", "Meladinine", "Meloxine", "Ultra Mop" ]	[]	[ "P11509" ]	[ "P04798", "Q16696", "P11509", "P05177" ]	[]	[]
DB00555	Lamotrigine	Lamotrigine is an antiepileptic drug belonging in the phenyltriazine class. It is used in the treatment of both epilepsy and as a mood stabilizer in bipolar disorder. Lamotrigine is the first medication since lithium granted Food and Drug Administration (FDA) approval for the maintenance treatment of bipolar type I. It is approved for use in more than 30 countries.[A191350] Lamotrigine has relatively few side-effects and does not require laboratory monitoring. While it is indicated for epilepsy and bipolar disorders, there is evidence that lamotrigine could have some clinical efficacy in certain neuropathic pain states.[A849,A850]	solid	Lamotrigine is indicated as adjunctive therapy for the following seizure types in patients ≥2 years of age: partial seizures, primary generalized tonic-clonic seizures, and generalized seizures due to Lennox-Gastaut syndrome.[L9404] It is also indicated for the process of conversion to drug monotherapy for those at least 16 years of age or older with partial seizures and currently are receiving treatment with carbamazepine, phenytoin, phenobarbital, primidone, or valproate as the single antiepileptic drug (AED).[L9404] In addition to the above, lamotrigine is also indicated for the maintenance treatment of bipolar I disorder, delaying the time to mood episodes (which may include mania, hypomania, depression, mixed episodes) in adults at least 18 years or older, who have been treated for acute mood symptoms with standard therapy.[L9404] Limitations of use It is important to note that lamotirigine should not be used in the treatment of acute mood episodes, as efficacy has not been established in this context.[L9404]	Lamotrigine likely prevents seizures and prevents mood symptoms via stabilizing presynaptic neuronal membranes and preventing the release of excitatory neurotransmitters such as glutamate, which contribute to seizure activity.[A191350,L9404] A note on cardiovascular effects The metabolite of lamotrigine, 2-N-methyl metabolite (formed by glucuronidation), is reported to cause dose-dependent prolongations of the PR interval, widening of the QRS complex, and at higher doses, complete AV block. Although this harmful metabolite is only found in trace amounts in humans, plasma concentrations may increase in conditions that cause decreased drug glucuronidation, such as liver disease.[A191335,L9404,L12183]	The exact mechanism of action of lamotrigine is not fully elucidated, as it may exert cellular activities that contribute to its efficacy in a range of conditions. Although chemically unrelated, lamotrigine actions resemble those of phenytoin and carbamazepine, inhibiting voltage-sensitive sodium channels, stabilizing neuronal membranes, thereby modulating the release of presynaptic excitatory neurotransmitters.[A191335,A191350,L9404] Lamotrigine likely acts by inhibiting sodium currents by selective binding to the inactive sodium channel, suppressing the release of the excitatory amino acid, glutamate. The mechanism of action of lamotrigine in reducing anticonvulsant activity is likely the same in managing bipolar disorder. Studies on lamotrigine have identified its binding to sodium channels in a fashion similar to local anesthetics, which could explain the demonstrated clinical benefit of lamotrigine in some neuropathic pain states.[T28] Lamotrigine displays binding properties to several different receptors. In laboratory binding assays, it demonstrates weak inhibitory effect on the serotonin 5-HT3 receptor. Lamotrigine also weakly binds to Adenosine A1/A2 receptors, α1/α2/β adrenergic receptors, dopamine D1/D2 receptors, GABA A/B receptors, histamine H1 receptors, κ-opioid receptor (KOR), mACh receptors and serotonin 5-HT2 receptors with an IC50>100 µM. Weak inhibitory effects were observed at sigma opioid receptors.[L9404] An in vivo study revealed evidence that lamotrigine inhibits Cav2.3 (R-type) calcium currents, which may also contribute to its anticonvulsant effects.[A31737]	Lamotrigine is rapidly and entirely absorbed with minimal first-pass metabolism effects, with a bioavailability estimated at 98%. Cmax is reached in the range of 1.4 to 4.8 hours post-dose, but this depends on the dose administered, concomitant medications, and epileptic status. The rate and extent of lamictal absorption is considered equivalent between the compressed tablet form taken with water to that of the chewable dispersible tablets, taken with or without water.[L9404,L12183]	Lamotrigine is mainly glucuronidated, forming 2-N-glucuronide conjugate, a pharmacologically inactive metabolite.[A192027] The total radioactivity detected after a 240mg radiolabeled dose of lamotrigine during clinical trials were as follows: lamotrigine as unchanged drug(10%), a 2-N-glucuronide (76%), a 5-N-glucuronide (10%), a 2-N-methyl metabolite (0.14%), as well as various other minor metabolites (4%).[L9404]	The oral LD50 in mouse and rat is 205 mg/kg and 245 mg/kg, respectively.[MSDS] Fatal cases of overdose of up to 15g of lamotrigine have been reported. Overdose with lamotrigine has been manifested by ataxia, nystagmus, increased seizures, decreased level of consciousness, coma, and intraventricular conduction delay. Though no known antidote exists for lamotrigine, hospitalization and general supportive measures should be employed in the case of a suspected lamotrigine overdose. Gastric lavage and emesis may be warranted with simultaneous protection of the airway. It is uncertain at this time whether hemodialysis is an effective means of removing lamotrigine from the sytemic circulation.[L12183,L9404]	The average elimination half-life of lamotrigine ranges from approximately 14-59 hours. The value is dependent on the dose administered, concomitant drug therapy, as well as disease status.[A191946,L12183] One pharmacokinetic study revealed a half-life of 22.8 to 37.4 hours in healthy volunteers. It also reported that enzyme-inducing antiepileptic drugs such as pheobarbital, phenytoin, or carbamazepine decrease the half-life of lamotrigine. On the other hand, valproic acid increases the half-life of lamotrigine (in the range of 48-59 hours).[A191946]	The plasma protein binding of lamotrigine is estimated at 55%.[A191946,L9404] This drug is not expected to undergo clinically significant interactions with other drugs via competition for protein binding sites due its lower protein binding.[L9404,L12183]	Lamotrigine is excreted in both the urine and feces.[A192027] Following oral administration of 240 mg radiolabelled lamotrigine, about 94% of total drug and its metabolites administered is recovered in the urine and 2% is recovered in the feces.[L9404] One pharmacokinetic study recovered 43 to 87% of a lamotrigine dose in the urine mainly as glucuronidated metabolites.[A191946] 2-N-glucuronide is mainly excreted in the urine.[A192027]	The mean apparent volume of distribution (Vd/F) of lamotrigine following oral administration ranges from 0.9 to 1.3 L/kg and is independent of dose administered. Lamotrigine accumulated in the kidney of the male rat, and likely behaves in a similar fashion in humans. Lamotrigine also binds to tissues containing melanin, such as the eyes and pigmented skin.[L9404,L12183]	The mean apparent plasma clearance (Cl/F) ranges from 0.18 to 1.21 mL/min/kg. The values vary depending on dosing regimen, concomitant antiepileptic medications, and disease state of the individual.[L9404] In one study, healthy volunteers on lamictal monotherapy showed a clearance of about 0.44 mL/min/kg after a single dose.[L9404]	Organic compounds	Benzenoids	Benzene and substituted derivatives	Halobenzenes	[ "approved", "investigational" ]	[ "N03AX", "N03A", "N03", "N" ]	[ "Humans and other mammals" ]	[ { "cost": "1.31", "description": "Apo-Lamotrigine 150 mg Tablet", "unit": "tablet" }, { "cost": "1.31", "description": "Mylan-Lamotrigine 150 mg Tablet", "unit": "tablet" }, { "cost": "1.31", "description": "Novo-Lamotrigine 150 mg Tablet", "unit": "tablet" }, { "cost": "1.31", "description": "Pms-Lamotrigine 150 mg Tablet", "unit": "tablet" }, { "cost": "1.31", "description": "Ratio-Lamotrigine 150 mg Tablet", "unit": "tablet" }, { "cost": "2.9", "description": "Lamotrigine 25 mg tablet", "unit": "tablet" }, { "cost": "3.18", "description": "LamoTRIgine 5 mg Chew Tabs", "unit": "tab" }, { "cost": "3.33", "description": "LamoTRIgine 25 mg Chew Tabs", "unit": "tab" }, { "cost": "3.52", "description": "Lamotrigine 100 mg tablet", "unit": "tablet" }, { "cost": "3.78", "description": "Lamictal 25 mg tablet", "unit": "tablet" }, { "cost": "3.98", "description": "Lamotrigine 150 mg tablet", "unit": "tablet" }, { "cost": "4.24", "description": "Lamotrigine tablet starter kit", "unit": "tablet" }, { "cost": "4.72", "description": "Lamictal 100 mg tablet", "unit": "tablet" }, { "cost": "5.1", "description": "Lamictal odt 25 mg tablet", "unit": "tablet" }, { "cost": "5.1", "description": "Lamictal xr 25 mg tablet", "unit": "tablet" }, { "cost": "5.38", "description": "Lamictal 150 mg tablet", "unit": "tablet" }, { "cost": "5.46", "description": "Lamictal odt 50 mg tablet", "unit": "tablet" }, { "cost": "5.46", "description": "Lamictal tab start kit (green)", "unit": "tablet" }, { "cost": "5.63", "description": "LaMICtal 25 mg Chew Tabs", "unit": "tab" }, { "cost": "5.78", "description": "Lamotrigine 200 mg tablet", "unit": "tablet" }, { "cost": "5.82", "description": "Lamictal odt 100 mg tablet", "unit": "tablet" }, { "cost": "6.95", "description": "Lamictal odt 200 mg tablet", "unit": "tablet" }, { "cost": "7.28", "description": "Lamictal odt start kt (orange)", "unit": "tablet" }, { "cost": "7.28", "description": "Lamictal xr start kit (orange)", "unit": "tablet" }, { "cost": "7.44", "description": "Lamictal 200 mg tablet", "unit": "tablet" }, { "cost": "10.2", "description": "Lamictal xr 50 mg tablet", "unit": "tablet" }, { "cost": "10.92", "description": "Lamictal xr 100 mg tablet", "unit": "tablet" }, { "cost": "11.36", "description": "LaMICtal XR 100 mg 24 Hour tablet", "unit": "tablet" }, { "cost": "11.65", "description": "Lamictal xr 200 mg tablet", "unit": "tablet" }, { "cost": "12.11", "description": "LaMICtal XR 200 mg 24 Hour tablet", "unit": "tablet" }, { "cost": "556.69", "description": "LaMICtal Starter 98 25 (84)-100(14)mg Kit Box", "unit": "box" }, { "cost": "0.18", "description": "Lamictal 5 mg Chewable Tablet", "unit": "tablet" }, { "cost": "0.22", "description": "Apo-Lamotrigine 25 mg Tablet", "unit": "tablet" }, { "cost": "0.22", "description": "Mylan-Lamotrigine 25 mg Tablet", "unit": "tablet" }, { "cost": "0.22", "description": "Novo-Lamotrigine 25 mg Tablet", "unit": "tablet" }, { "cost": "0.22", "description": "Pms-Lamotrigine 25 mg Tablet", "unit": "tablet" }, { "cost": "0.22", "description": "Ratio-Lamotrigine 25 mg Tablet", "unit": "tablet" }, { "cost": "0.88", "description": "Apo-Lamotrigine 100 mg Tablet", "unit": "tablet" }, { "cost": "0.88", "description": "Mylan-Lamotrigine 100 mg Tablet", "unit": "tablet" }, { "cost": "0.88", "description": "Novo-Lamotrigine 100 mg Tablet", "unit": "tablet" }, { "cost": "0.88", "description": "Pms-Lamotrigine 100 mg Tablet", "unit": "tablet" }, { "cost": "0.88", "description": "Ratio-Lamotrigine 100 mg Tablet", "unit": "tablet" } ]	[ { "approved": "1997-12-16", "country": "United States", "expires": "2012-07-29", "number": "5698226" }, { "approved": "2001-03-27", "country": "Canada", "expires": "2012-01-29", "number": "2277722" }, { "approved": "2015-09-29", "country": "United States", "expires": "2023-09-22", "number": "9144547" }, { "approved": "2014-01-28", "country": "United States", "expires": "2028-06-14", "number": "8637512" }, { "approved": "2014-09-23", "country": "United States", "expires": "2028-07-02", "number": "8840925" }, { "approved": "2011-04-05", "country": "United States", "expires": "2029-01-04", "number": "7919115" }, { "approved": "2016-05-17", "country": "United States", "expires": "2028-07-02", "number": "9339504" } ]	3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine \| Lamotrigina \| Lamotrigine \| Lamotriginum \| BII \| Brain calcium channel II \| CACH6 \| CACNL1A6 \| Calcium channel, L type, alpha-1 polypeptide, isoform 6 \| Voltage-gated calcium channel subunit alpha Cav2.3 \| hNaN \| Peripheral nerve sodium channel 5 \| PN5 \| SCN12A \| Sensory neuron sodium channel 2 \| SNS2 \| Sodium channel protein type XI subunit alpha \| Voltage-gated sodium channel subunit alpha Nav1.9 \| NAC1 \| SCN1 \| Sodium channel protein brain I subunit alpha \| Sodium channel protein type I subunit alpha \| Voltage-gated sodium channel subunit alpha Nav1.1 \| hPN3 \| Peripheral nerve sodium channel 3 \| PN3 \| Sodium channel protein type X subunit alpha \| Voltage-gated sodium channel subunit alpha Nav1.8 \| hNaN \| Peripheral nerve sodium channel 5 \| PN5 \| SCN12A \| Sensory neuron sodium channel 2 \| SNS2 \| Sodium channel protein type XI subunit alpha \| Voltage-gated sodium channel subunit alpha Nav1.9 \| HBA \| HBSC II \| NAC2 \| SCN2A1 \| SCN2A2 \| Sodium channel protein brain II subunit alpha \| Sodium channel protein type II subunit alpha \| Voltage-gated sodium channel subunit alpha Nav1.2 \| KIAA1356 \| NAC3 \| Sodium channel protein brain III subunit alpha \| Sodium channel protein type III subunit alpha \| Voltage-gated sodium channel subtype III \| Voltage-gated sodium channel subunit alpha Nav1.3 \| SkM1 \| Sodium channel protein skeletal muscle subunit alpha \| Sodium channel protein type IV subunit alpha \| Voltage-gated sodium channel subunit alpha Nav1.4 \| hH1 \| Sodium channel protein cardiac muscle subunit alpha \| Sodium channel protein type V subunit alpha \| Voltage-gated sodium channel subunit alpha Nav1.5 \| Atypical sodium channel Nav2.1 \| Nax channel \| SCN6A \| Sodium channel protein type VII subunit alpha \| MED \| Sodium channel protein type VIII subunit alpha \| Voltage-gated sodium channel subunit alpha Nav1.6 \| hNE-Na \| NENA \| Neuroendocrine sodium channel \| Peripheral sodium channel 1 \| PN1 \| Sodium channel protein type IX subunit alpha \| Voltage-gated sodium channel subunit alpha Nav1.7 \| ADORA2 \| ADRA1C \| Alpha-1A adrenoceptor \| Alpha-1A adrenoreceptor \| Alpha-1C adrenergic receptor \| Alpha-adrenergic receptor 1c \| ADRA2R \| ADRAR \| Alpha-2 adrenergic receptor subtype C10 \| Alpha-2A adrenoceptor \| Alpha-2A adrenoreceptor \| Alpha-2AAR \| ADRB1R \| B1AR \| Beta-1 adrenoceptor \| Beta-1 adrenoreceptor \| Dopamine D1 receptor \| D(5) dopamine receptor \| D1beta dopamine receptor \| Dopamine D5 receptor \| DRD1B \| DRD1L2 \| Dopamine D2 receptor \| GABA(A) receptor subunit alpha-1 \| GABAAR subunit alpha-1 \| GABA(A) receptor subunit alpha-2 \| GABAAR subunit alpha-2 \| GABA(A) receptor subunit alpha-3 \| GABAAR subunit alpha-3 \| GABA(A) receptor subunit alpha-4 \| GABAAR subunit alpha-4 \| GABA(A) receptor subunit alpha-5 \| GABAAR subunit alpha-5 \| GABA(A) receptor subunit alpha-6 \| GABAAR subunit alpha-6 \| GABA(A) receptor subunit beta-1 \| GABAAR subunit beta-1 \| GABA(A) receptor subunit beta-2 \| GABAAR subunit beta-2 \| GABA(A) receptor subunit beta-3 \| GABAAR subunit beta-3 \| GABA(A) receptor subunit delta \| GABAAR subunit delta \| GABA(A) receptor subunit epsilon \| GABAAR subunit epsilon \| GABA(A) receptor subunit gamma-1 \| GABAAR subunit gamma-1 \| GABA(A) receptor subunit gamma-2 \| GABAAR subunit gamma-2 \| GABA(A) receptor subunit gamma-3 \| GABAAR subunit gamma-3 \| GABA(A) receptor subunit pi \| GABAAR subunit pi \| GABA(A) receptor subunit theta \| GABAAR subunit theta \| GABA(A) receptor subunit alpha-1 \| GABAAR subunit alpha-1 \| GABA(A) receptor subunit alpha-2 \| GABAAR subunit alpha-2 \| GABA(A) receptor subunit alpha-3 \| GABAAR subunit alpha-3 \| GABA(A) receptor subunit alpha-5 \| GABAAR subunit alpha-5 \| GABA(A) receptor subunit gamma-1 \| GABAAR subunit gamma-1 \| GABA(A) receptor subunit gamma-2 \| GABAAR subunit gamma-2 \| GABA(A) receptor subunit gamma-3 \| GABAAR subunit gamma-3 \| H1-R \| H1R \| HH1R \| K-OR-1 \| KOR-1 \| OPRK \| ACHRA \| CHNRA \| 5-HT-2 \| 5-HT-2A \| HTR2 \| Serotonin receptor 2A \| 5-HT-3 \| 5-HT3-A \| 5-HT3A \| 5-HT3R \| 5-hydroxytryptamine receptor 3 \| 5HT3R \| HTR3 \| Serotonin receptor 3A \| Serotonin-gated ion channel receptor \| AMPA-selective glutamate receptor 1 \| GLUA1 \| GLUH1 \| GluR-1 \| GluR-A \| GluR-K1 \| GLUR1 \| Glutamate receptor ionotropic, AMPA 1 \| 1.5.1.3 \| 2.4.1.17 \| GNT1 \| Phenol-metabolizing UDP-glucuronosyltransferase \| UDP-glucuronosyltransferase 1-F \| UDP-glucuronosyltransferase 1A6 \| UDPGT 1-6 \| UGT-1F \| UGT1 \| UGT1-06 \| UGT1.6 \| UGT16 \| UGT1F \| 2.4.1.17 \| Bilirubin-specific UDPGT isozyme 1 \| GNT1 \| hUG-BR1 \| UDP-glucuronosyltransferase 1-1 \| UDP-glucuronosyltransferase 1A isoform 1 \| UDPGT 1-1 \| UGT1 \| UGT1-01 \| UGT1.1 \| UGT11 \| UGT1A1 \| 2.4.1.17 \| GNT1 \| UDP-glucuronosyltransferase 1-10 \| UDP-glucuronosyltransferase 1-J \| UDPGT 1-10 \| UGT-1J \| UGT1 \| UGT1-10 \| UGT1.10 \| UGT110 \| UGT1A10 \| UGT1J \| 2.4.1.17 \| GNT1 \| UDP-glucuronosyltransferase 1-3 \| UDP-glucuronosyltransferase 1-C \| UDP-glucuronosyltransferase 1A isoform 3 \| UDPGT 1-3 \| UGT-1C \| UGT1 \| UGT1-03 \| UGT1.3 \| UGT13 \| UGT1A3 \| UGT1C \| 2.4.1.17 \| Bilirubin-specific UDPGT isozyme 2 \| GNT1 \| hUG-BR2 \| UDP-glucuronosyltransferase 1-4 \| UDP-glucuronosyltransferase 1-D \| UDPGT 1-4 \| UGT-1D \| UGT1 \| UGT1-04 \| UGT1.4 \| UGT14 \| UGT1A4 \| UGT1D \| 2.4.1.17 \| GNT1 \| UDP-glucuronosyltransferase 1-7 \| UDP-glucuronosyltransferase 1-G \| UDPGT 1-7 \| UGT-1G \| UGT1 \| UGT1-07 \| UGT1.7 \| UGT17 \| UGT1A7 \| UGT1G \| 2.4.1.17 \| GNT1 \| UDP-glucuronosyltransferase 1-8 \| UDP-glucuronosyltransferase 1-H \| UDPGT 1-8 \| UGT-1H \| UGT1 \| UGT1-08 \| UGT1.8 \| UGT18 \| UGT1A8 \| UGT1H \| 2.4.1.17 \| GNT1 \| lugP4 \| UDP-glucuronosyltransferase 1-9 \| UDP-glucuronosyltransferase 1-I \| UDPGT 1-9 \| UGT-1I \| UGT1 \| UGT1-09 \| UGT1.9 \| UGT19 \| UGT1A9 \| UGT1I \| 2.4.1.17 \| HLUG4 \| UDP-glucuronosyltransferase 2B8 \| UDPGT 2B15 \| UDPGT 2B8 \| UDPGTh-3 \| UGT2B15 \| UGT2B8 \| 2.4.1.17 \| HLUG25 \| Hyodeoxycholic acid-specific UDPGT \| UDPGT 2B4 \| UDPGTh-1 \| UGT2B11 \| UGT2B4 \| 2.4.1.17 \| 3,4-catechol estrogen-specific UDPGT \| UDP-glucuronosyltransferase 2B9 \| UDPGT 2B7 \| UDPGT 2B9 \| UDPGTh-2 \| UGT2B7 \| UGTB2B9 \| ATP-binding cassette sub-family B member 1 \| MDR1 \| Multidrug resistance protein 1 \| P-glycoprotein 1 \| PGY1 \| Phospholipid transporter ABCB1 \| hOCT2 \| OCT2 \| Organic cation transporter 2 \| hOCT1 \| OCT1 \| Organic cation transporter 1	[ "Ag-lamotrigine", "Ag-lamotrigine", "Ag-lamotrigine", "Apo-lamotrigine", "Apo-lamotrigine", "Apo-lamotrigine", "Auro-lamotrigine", "Auro-lamotrigine", "Auro-lamotrigine", "Dom-lamotrigine", "Dom-lamotrigine", "Dom-lamotrigine", "Jamp Lamotrigine", "Jamp Lamotrigine", "Jamp Lamotrigine", "Lamictal", "Lamictal", "Lamictal", "Lamictal", "Lamictal", "Lamictal", "Lamictal", "Lamictal", "Lamictal", "Lamictal", "Lamictal", "Lamictal", "Lamictal", "Lamictal", "Lamictal", "Lamictal", "Lamictal", "Lamictal", "Lamictal", "Lamictal", "Lamictal", "Lamictal", "Lamictal", "Lamictal", "Lamictal", "Lamictal", "Lamictal", "Lamictal", "Lamictal", "Lamictal - Tab 200mg", "Lamictal ODT", "Lamictal ODT", "Lamictal ODT", "Lamictal ODT", "Lamictal ODT", "Lamictal ODT", "Lamictal ODT", "Lamictal ODT", "Lamictal ODT", "Lamictal ODT", "Lamictal ODT", "Lamictal XR", "Lamictal XR", "Lamictal XR", "Lamictal XR", "Lamictal XR", "Lamictal XR", "Lamictal XR", "Lamictal XR", "Lamictal XR", "Lamictal XR", "Lamictal XR", "Lamictal XR", "Lamictal XR", "Lamictal XR", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine ER", "Lamotrigine ER", "Lamotrigine Extended Release", "Lamotrigine Extended Release", "Lamotrigine Extended Release", "Lamotrigine Extended Release", "Lamotrigine Extended Release", "Lamotrigine Extended Release", "Lamotrigine Extended Release", "Lamotrigine Extended Release", "Lamotrigine Extended Release", "Lamotrigine Extended Release", "Lamotrigine Extended Release", "Lamotrigine Extended Release", "LAMOTRIGINE Kit", "LAMOTRIGINE Kit", "LAMOTRIGINE Kit", "LAMOTRIGINE Kit", "Lamotrigine-100", "Lamotrigine-150", "Lamotrigine-25", "Mylan-lamotrigine", "Mylan-lamotrigine", "Mylan-lamotrigine", "Nu-lamotrigine", "Nu-lamotrigine", "Nu-lamotrigine", "PHL-lamotrigine", "PHL-lamotrigine", "PHL-lamotrigine", "PMS-lamotrigine", "PMS-lamotrigine", "PMS-lamotrigine", "Ratio-lamotrigine", "Ratio-lamotrigine", "Ratio-lamotrigine", "Subvenite", "Subvenite", "Subvenite", "Subvenite", "Subvenite", "Subvenite", "Subvenite", "Subvenite", "Subvenite", "Subvenite", "Subvenite", "Teva-lamotrigine", "Teva-lamotrigine", "Teva-lamotrigine" ]	[ "Convulsan", "Crisomet", "Dafex", "Daksol", "Danoptin", "Dezepil", "Elmendos", "Epilepax", "Epimil", "Epiral", "Epitec", "Epitrigine", "Labileno", "Lambipol", "Lamect", "Lameptil", "Lameptil S", "Lametec", "Lamez", "Lamictal CD", "Lamictin", "Lamotrix", "Larig", "Medotrigin", "Mogine", "Trimolep", "Trogine", "Xebarin" ]	[ "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamictal XR", "Lamictal XR", "Lamictal XR", "Lamictal XR", "Lamictal XR", "Lamictal XR", "Lamictal XR", "Lamictal XR", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Lamotrigine", "Subvenite", "Subvenite", "Subvenite", "Subvenite", "LAMOTRIGINE Kit", "LAMOTRIGINE Kit", "LAMOTRIGINE Kit", "LAMOTRIGINE Kit", "Lamictal", "Lamictal", "Lamictal ODT", "Lamictal ODT", "Lamictal ODT", "Lamictal ODT", "Lamictal ODT", "Lamictal ODT", "Lamictal ODT", "Lamictal", "Lamictal", "Lamotrigine", "Lamotrigine" ]	[ "Q15878", "Q9UI33", "P35498", "Q9Y5Y9", "Q9UI33", "Q99250", "Q9NY46", "P35499", "Q14524", "Q01118", "Q9UQD0", "Q15858", "P30542", "P29274", "P35348", "P08913", "P08588", "P21728", "P21918", "P14416", "P14867", "P47869", "P34903", "P48169", "P31644", "Q16445", "P18505", "P47870", "P28472", "O14764", "P78334", "Q8N1C3", "P18507", "Q99928", "O00591", "Q9UN88", "P14867", "P47869", "P34903", "P31644", "Q8N1C3", "P18507", "Q99928", "P35367", "P41145", "P02708", "P28223", "P46098", "P42261" ]	[ "P00374", "P19224", "P22309", "Q9HAW8", "P35503", "P22310", "Q9HAW7", "Q9HAW9", "O60656", "P54855", "P06133", "P16662" ]	[ "P02768" ]	[ "P08183", "O15244", "O15245" ]
DB00556	Perflutren	Perflutren, a diagnostic drug that is intended to be used for contrast enhancement during the indicated echocardiographic procedures, is comprised of lipid-coated microspheres filled with octafluoropropane(OFP) gas. When exposed to ultrasound waves, the microspheres resonate and "echo" strong signals back to the ultrasound machine. The difference in density between the gas-filled bubbles and the blood around them creates an increased level of contrast visible in the resulting ultrasound image. During echocardiography, activated Perflutren enhances images of the inner edges or borders of the heart, producing an improved image that may enable physicians to better diagnose patients.	liquid	Used as an ultrasound contrast imaging in cardiology and radiology.	Perflutren, a diagnostic drug that is intended to be used for contrast enhancement during the indicated echocardiographic procedures, comprised of lipid-coated microspheres filled with octafluoropropane(OFP) gas. It provide contrast enhancement of the endocardial borders during echocardiography. The perflutren lipid microspheres exhibit lower acoustic impedance than blood and enhance the intrinsic backscatter of blood.	Perflutren is comprised of gas-filled microspheres that are injected or infused into the body. When exposed to ultrasound waves, the microspheres resonate and "echo" strong signals back to the ultrasound machine. The difference in density between the gas-filled bubbles and the blood around them creates an increased level of contrast visible in the resulting ultrasound image. During echocardiography, activated Perflutren enhances images of the inner edges or borders of the heart, producing an improved image that may enable physicians to better diagnose patients.	null	OFP is not metabolized. The phospholipid components of the microspheres are thought to be metabolized to free fatty acids.	There is new temporal evidence that perflutren may be associated with new-onset seizure activity following perflutren microbubble contrast injection during dobutamine-atropine stress echocardiography. [PMID: 23432576]	The mean half-life of OFP in blood 1.9 minutes	null	null	null	null	Organic compounds	Organohalogen compounds	Organofluorides	null	[ "approved" ]	[]	[ "Humans and other mammals" ]	[ { "cost": "56.16", "description": "Optison vial", "unit": "ml" } ]	[ { "approved": "2000-11-14", "country": "United States", "expires": "2009-12-22", "number": "6146657" }, { "approved": "2010-06-01", "country": "Canada", "expires": "2017-06-16", "number": "2256592" }, { "approved": "2001-07-03", "country": "Canada", "expires": "2012-03-18", "number": "2107466" }, { "approved": "2000-03-07", "country": "United States", "expires": "2016-06-19", "number": "6033645" }, { "approved": "2014-04-01", "country": "United States", "expires": "2019-01-13", "number": "8685441" }, { "approved": "2014-02-25", "country": "United States", "expires": "2019-04-20", "number": "8658205" }, { "approved": "2017-01-17", "country": "United States", "expires": "2019-01-13", "number": "9545457" }, { "approved": "2017-10-17", "country": "United States", "expires": "2037-03-16", "number": "9789210" }, { "approved": "2004-04-20", "country": "United States", "expires": "2021-04-20", "number": "6723303" }, { "approved": "2020-03-17", "country": "United States", "expires": "2037-05-04", "number": "10588988" }, { "approved": "2020-03-10", "country": "United States", "expires": "2035-12-28", "number": "10583207" }, { "approved": "2020-03-10", "country": "United States", "expires": "2037-03-16", "number": "10583208" }, { "approved": "2018-07-17", "country": "United States", "expires": "2035-12-28", "number": "10022460" }, { "approved": "2017-03-16", "country": "United States", "expires": "2037-03-16", "number": "11266750" }, { "approved": "2015-12-28", "country": "United States", "expires": "2035-12-28", "number": "11395856" }, { "approved": "2017-03-16", "country": "United States", "expires": "2037-03-16", "number": "11529431" }, { "approved": "2017-03-16", "country": "United States", "expires": "2037-03-16", "number": "11857646" }, { "approved": "2017-03-16", "country": "United States", "expires": "2037-03-16", "number": "11925695" } ]	1,1,1,2,2,3,3,3-octafluoropropane \| Freon 218 \| Octafluoropropane \| Octafluorpropan \| Oktafluorpropan \| Perfluoropropane \| Perflutren \| Perflutreno	[ "Definity", "Definity", "Definity RT", "Luminity", "Luminity", "Optison", "Optison", "Optison Perflutren Protein-Type A Microspheres" ]	[ "Optison" ]	[ "Optison Perflutren Protein-Type A Microspheres" ]	[]	[]	[]	[]
DB00557	Hydroxyzine	Hydroxyzine is a first-generation histamine H<sub>1</sub>-receptor antagonist of the dephenylmethane and piperazine classes that exhibits sedative, anxiolytic, and antiemetic properties.[A1257,A187589] It was first developed in 1955,[A189726] and has since remained a relatively common treatment for allergic conditions such as pruritus, urticaria, dermatoses, and histamine-mediated pruritus.[L9677] The active metabolite of hydroxyzine, [cetirizine], is also available as an active ingredient in allergic medications, and is responsible for much of its hydroxyzine's antihistaminic effect.[A189753] Hydroxyzine is also used for generalized anxiety disorder, tension caused by psychoneurosis, and other conditions with manifestations of anxiety.[L9677]	solid	Hydroxyzine is indicated for the symptomatic relief of anxiety and tension associated with psychoneuroses, and as an adjunct in organic disease states in which anxiety is manifested.[L9677] It is also indicated in the treatment of histamine-mediated pruritus and pruritus due to allergic conditions such as chronic urticaria.[L9677] Canadian labeling states that hydroxyzine is also indicated in adults and children as a premedication prior to medical procedures, such as dental surgery.[L9680] It is also used in the control of nausea and vomiting, excluding nausea and vomiting of pregnancy.[L9680]	Hydroxyzine blocks the activity of histamine to relieve allergic symptoms such as pruritus.[L9677] Activity at off-targets also allows for its use as a sedative anxiolytic and an antiemetic in certain disease states.[L9680] Hydroxyzine is relatively fast-acting, with an onset of effect that occurs between 15 and 60 minutes and a duration of action between 4-6 hours.[A1257] Hydroxyzine may potentiate the effects of central nervous system (CNS) depressants following general anesthesia - patients maintained on hydroxyzine should receive reduced doses of any CNS depressants required.[L9677] Hydroxyzine is reported to prolong the QT/QTc interval based on postmarketing reports of rare events of Torsade de Pointes, cardiac arrest, and sudden death, and should be used with caution in patients with an increased baseline risk for QTc prolongation.[L9680,A189726]	The H<sub>1</sub> histamine receptor is responsible for mediating hypersensitivity and allergic reactions. Exposure to an allergen results in degranulation of mast cells and basophils, which then release histamine and other inflammatory mediators. Histamine binds to, and activates, H<sub>1</sub> receptors, which results in the further release of pro-inflammatory cytokines, such as interleukins, from basophils and mast cells. These downstream effects of histamine binding are responsible for a wide variety of allergic symptoms, such as pruritus, rhinorrhea, and watery eyes.[A1495] Hydroxyzine is a potent inverse agonist of histamine H<sub>1</sub>-receptors[A1257] - inverse agonists are agents that are considered to have a "negative efficacy", so rather than simply blocking activity at a receptor they actively dampen its activity.[T707] Inverse agonism at these receptors is responsible for hydroxyzine's efficacy in the treatment of histaminic edema, flare, and pruritus. Hydroxyzine is not a cortical depressant, so its sedative properties likely occur at the subcortical level of the CNS.[L9677] These sedative properties allow activity as an anxiolytic. Antiemetic efficacy is likely secondary to activity at off-targets.[A189753]	The absolute bioavailability of hydroxyzine has not been ascertained, as intravenous formulations are unavailable due to a risk of hemolysis.[A1257] Hydroxyzine is rapidly absorbed from the gastrointestinal tract upon oral administration,[L9677] reaching its maximum plasma concentration (T<sub>max</sub>) approximately 2 hours following administration.[A189705]	Hydroxyzine is metabolized in the liver[A1257] by CYP3A4 and CYP3A5.[L9677] While the precise metabolic fate of hydroxyzine is unclear, its main and active metabolite (~45 to 60% of an orally administered dose),[A189753] generated by oxidation of its alcohol moiety to a carboxylic acid, is the second-generation antihistamine [cetirizine].[A1257] Hydroxyzine is likely broken down into several other metabolites, though specific structures and pathways have not been elucidated in humans.[A189699]	The oral LD<sub>50</sub> is 840 mg/kg in rats and 400 mg/kg in mice.[L9722] Overdose from hydroxyzine is most commonly characterized by hypersedation, but may also manifest as convulsions, stupor, nausea, and vomiting.[L9677] In cases of overdose, consider the induction of vomiting and the use of gastric lavage. Other treatment should involve general symptomatic and supportive care. Hypotension may be controlled by intravenous fluids and pressors, and caffeine and sodium benzoate injection may be used to counteract any observed CNS depressant effects. Hemodialysis is unlikely to provide any benefit in the treatment hydroxyzine overdose.[L9677]	The half-life of hydroxyzine is reportedly 14-25 hours,[A1257] and appears to be, on average, shorter in children (~7.1 hours) than in adults (~20 hours).[A644] Elimination half-life is prolonged in the elderly, averaging approximately 29 hours,[A187814] and is likely to be similarly prolonged in patients with renal or hepatic impairment.[L9680]	Hydroxyzine has been shown to bind to human albumin _in vitro_,[A189702] but the extent of protein binding in plasma has not been evaluated.	Approximately 70% of hydroxyzine's active metabolite, cetirizine, is excreted unchanged in the urine.[A187814] The precise extent of renal and fecal excretion in humans has not been determined.[L9677]	The mean volume of distribution is 16.0 ± 3.0 L/kg. Higher concentrations are found in the skin than in the plasma.[A1257]	Clearance of hydroxyzine has been reported to be 31.1 ± 11.1 mL/min/kg in children and 9.8 ± 3.3 mL/min/kg in adults.[A644]	Organic compounds	Benzenoids	Benzene and substituted derivatives	Diphenylmethanes	[ "approved" ]	[ "N05BB", "N05B", "N05", "N", "N05BB", "N05B", "N05", "N" ]	[ "Humans and other mammals" ]	[ { "cost": "1.19", "description": "Hydroxyzine hcl 50 mg tablet", "unit": "tablet" }, { "cost": "1.7", "description": "Vistaril 100 mg capsule", "unit": "capsule" }, { "cost": "1.71", "description": "Vistaril 25 mg capsule", "unit": "capsule" }, { "cost": "1.78", "description": "HydrOXYzine HCl 50 mg/ml vial", "unit": "vial" }, { "cost": "2.03", "description": "Vistaril 50 mg capsule", "unit": "capsule" }, { "cost": "2.14", "description": "Hydroxyzine pamoate powder", "unit": "g" }, { "cost": "2.75", "description": "Hydroxyzine hcl powder", "unit": "g" }, { "cost": "3.6", "description": "Hydroxyzine 25 mg/ml vial", "unit": "ml" }, { "cost": "3.96", "description": "Hydroxyzine 50 mg/ml vial", "unit": "ml" }, { "cost": "4.42", "description": "Hydroxyzine Hcl 50 mg/ml", "unit": "ml" }, { "cost": "0.04", "description": "Pms-Hydroxyzine 2 mg/ml Syrup", "unit": "ml" }, { "cost": "0.06", "description": "Atarax 2 mg/ml Syrup", "unit": "ml" }, { "cost": "0.12", "description": "Apo-Hydroxyzine 10 mg Capsule", "unit": "capsule" }, { "cost": "0.12", "description": "Novo-Hydroxyzin 10 mg Capsule", "unit": "capsule" }, { "cost": "0.13", "description": "HydrOXYzine HCl 10 mg/5ml Syrup", "unit": "ml" }, { "cost": "0.15", "description": "Apo-Hydroxyzine 25 mg Capsule", "unit": "capsule" }, { "cost": "0.15", "description": "Novo-Hydroxyzin 25 mg Capsule", "unit": "capsule" }, { "cost": "0.22", "description": "Apo-Hydroxyzine 50 mg Capsule", "unit": "capsule" }, { "cost": "0.22", "description": "Novo-Hydroxyzin 50 mg Capsule", "unit": "capsule" }, { "cost": "0.23", "description": "HydrOXYzine Pamoate 50 mg capsule", "unit": "capsule" }, { "cost": "0.3", "description": "HydrOXYzine Pamoate 25 mg capsule", "unit": "capsule" }, { "cost": "0.45", "description": "Vistaril 25 mg/5ml Suspension", "unit": "ml" }, { "cost": "0.46", "description": "Hydroxyzine pam 25 mg capsule", "unit": "capsule" }, { "cost": "0.63", "description": "Hydroxyzine pam 100 mg capsule", "unit": "capsule" }, { "cost": "0.64", "description": "Hydroxyzine pam 50 mg capsule", "unit": "capsule" }, { "cost": "0.67", "description": "HydrOXYzine Pamoate 100 mg capsule", "unit": "capsule" }, { "cost": "0.7", "description": "Hydroxyzine hcl 25 mg tablet", "unit": "tablet" }, { "cost": "0.72", "description": "Hydroxyzine hcl 10 mg tablet", "unit": "tablet" } ]	[]	Hidroxizina \| Hychotine \| Hydroksyzyny \| Hydroxine \| Hydroxizine \| Hydroxizinum \| Hydroxycine \| Hydroxyzin \| Hydroxyzine \| Hydroxyzinum \| Idrossizina \| H1-R \| H1R \| HH1R \| Eag homolog \| Eag-related protein 1 \| ERG \| ERG-1 \| ERG1 \| Ether-a-go-go-related gene potassium channel 1 \| Ether-a-go-go-related protein 1 \| H-ERG \| HERG \| hERG-1 \| hERG1 \| Potassium voltage-gated channel subfamily H member 2 \| Voltage-gated potassium channel subunit Kv11.1 \| 1,4-cineole 2-exo-monooxygenase \| 1,8-cineole 2-exo-monooxygenase \| 1.14.14.1 \| Albendazole monooxygenase (sulfoxide-forming) \| Albendazole sulfoxidase \| Cholesterol 25-hydroxylase \| CYP3A3 \| CYPIIIA3 \| CYPIIIA4 \| Cytochrome P450 3A3 \| Cytochrome P450 HLp \| Cytochrome P450 NF-25 \| Cytochrome P450-PCN1 \| Nifedipine oxidase \| Quinine 3-monooxygenase \| 1.14.14.1 \| CYPIIIA5 \| Cytochrome P450-PCN3 \| 1.14.14.- \| Cholesterol 25-hydroxylase \| CYP2DL1 \| CYPIID6 \| Cytochrome P450-DB1 \| Debrisoquine 4-hydroxylase \| ATP-binding cassette sub-family B member 1 \| MDR1 \| Multidrug resistance protein 1 \| P-glycoprotein 1 \| PGY1 \| Phospholipid transporter ABCB1	[ "Atarax", "Atarax", "Atarax", "Atarax", "Atarax", "Atarax", "Atarax Cap 10mg", "Atarax Cap 25mg", "Atarax Cap 50mg", "Atarax Im Sol 50mg/ml", "Hydroxyzine", "Hydroxyzine", "Hydroxyzine", "Hydroxyzine", "Hydroxyzine", "Hydroxyzine", "Hydroxyzine", "Hydroxyzine", "Hydroxyzine", "Hydroxyzine", "Hydroxyzine", "Hydroxyzine", "Hydroxyzine", "Hydroxyzine", "Hydroxyzine", "Hydroxyzine", "Hydroxyzine", "Hydroxyzine", "Hydroxyzine", "Hydroxyzine HCl", "Hydroxyzine HCl", "Hydroxyzine HCl", "Hydroxyzine HCl", "Hydroxyzine HCL", "Hydroxyzine HCL", "Hydroxyzine HCl Oral Solution", "Hydroxyzine hydrochloride", "Hydroxyzine hydrochloride", "Hydroxyzine hydrochloride", "Hydroxyzine hydrochloride", "Hydroxyzine hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine hydrochloride", "Hydroxyzine hydrochloride", "Hydroxyzine hydrochloride", "HydrOXYzine hydrochloride", "HydrOXYzine hydrochloride", "HydrOXYzine hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "HydrOXYzine Hydrochloride", "HydrOXYzine Hydrochloride", "HydrOXYzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine hydrochloride", "Hydroxyzine hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "HydrOXYzine Hydrochloride", "HydrOXYzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine hydrochloride", "Hydroxyzine 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Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "HydrOXYzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "HydrOXYzine Hydrochloride", "Hydroxyzine hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "HydrOXYzine Hydrochloride", "HydrOXYzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "HydrOXYzine Hydrochloride", "HydrOXYzine Hydrochloride", "HydrOXYzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine hydrochloride", "Hydroxyzine hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine hydrochloride", "Hydroxyzine hydrochloride", "Hydroxyzine Hydrochloride", "HydrOXYzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine hydrochloride", "Hydroxyzine hydrochloride", "Hydroxyzine hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine hydrochloride", "Hydroxyzine hydrochloride", "Hydroxyzine hydrochloride", "Hydroxyzine hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine hydrochloride", "Hydroxyzine hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine hydrochloride", "Hydroxyzine Hydrochloride", "HydrOXYzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine hydrochloride", "Hydroxyzine hydrochloride", "HydrOXYzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine hydrochloride", "Hydroxyzine hydrochloride", "Hydroxyzine Hydrochloride", "HydrOXYzine Hydrochloride", "Hydroxyzine hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine hydrochloride", "Hydroxyzine hydrochloride", "Hydroxyzine hydrochloride", "Hydroxyzine hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine hydrochloride", "Hydroxyzine hydrochloride", "Hydroxyzine hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "HydrOXYzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "HydrOXYzine Hydrochloride", "Hydroxyzine hydrochloride", "Hydroxyzine hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "HydrOXYzine Hydrochloride", "Hydroxyzine hydrochloride", "Hydroxyzine hydrochloride", "Hydroxyzine hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "HydrOXYzine Hydrochloride", "HydrOXYzine Hydrochloride", "Hydroxyzine hydrochloride", "HydrOXYzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine hydrochloride", "Hydroxyzine hydrochloride", "Hydroxyzine hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "HydrOXYzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine Hydrochloride", "Hydroxyzine hydrochloride", "Hydroxyzine hydrochloride", "Hydroxyzine hydrochloride", "Hydroxyzine Hydrochloride Injection", "Hydroxyzine Hydrochloride Injection USP", "Hydroxyzine Hydrochloride Injection, USP", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine pamoate", "Hydroxyzine Pamoate", "Hydroxyzine pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine pamoate", "Hydroxyzine pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine pamoate", "Hydroxyzine pamoate", "Hydroxyzine Pamoate", "Hydroxyzine pamoate", "Hydroxyzine pamoate", "Hydroxyzine pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine Pamoate", "Hydroxyzine-10", "Hydroxyzine-25", "Hydroxyzine-50", "MKH Dose Pack", "Multipax Cap 10mg", "Multipax Cap 25mg", "Novo-hydroxyzin", "Novo-hydroxyzin", "Novo-hydroxyzin", "Nu-hydroxyzine", "Nu-hydroxyzine", "Nu-hydroxyzine", "Orgatrax", "Orgatrax", "PMS Hydroxyzine Cap 10mg", "PMS Hydroxyzine Cap 25mg", "PMS Hydroxyzine Cap 50mg", "PMS Hydroxyzine Syr 10mg/5ml", "Riva-hydroxyzin 10mg Capsules", "Riva-hydroxyzin 25mg Capsules", "Riva-hydroxyzin 50mg Capsules", "Vistaril", "Vistaril", "Vistaril", "Vistaril", "Vistaril", "Vistaril", "Vistaril", "Vistaril" ]	[ "Hyzine", "Masmoran", "Rezine", "Vistaject-50", "Vistazine" ]	[ "MKH Dose Pack" ]	[ "P35367", "Q12809" ]	[ "P08684", "P20815", "P10635" ]	[ "P02768" ]	[ "P08183" ]
DB00558	Zanamivir	A guanido-neuraminic acid that is used to inhibit neuraminidase.	solid	For the prevention and treatment of influenza A and B.	Zanamivir, an antiviral agent, is a neuraminidase inhibitor indicated for treatment of uncomplicated acute illness due to influenza A and B virus in adults and pediatric patients 7 years and older who have been symptomatic for no more than 2 days. Zanamivir has also been shown to significantly inhibit the human sialidases NEU3 and NEU2 in the micromolar range (Ki 3.7 +/-0.48 and 12.9+/-0.07 microM, respectively), which could account for some of the rare side effects of zanamivir.	The proposed mechanism of action of zanamivir is via inhibition of influenza virus neuraminidase with the possibility of alteration of virus particle aggregation and release. By binding and inhibiting the neuraminidase protein, the drug renders the influenza virus unable to escape its host cell and infect others.	Absolute bioavailability is very low following oral administration (2%). Following oral inhalation, bioavailability is 4% to 17%.	Not metabolized	null	2.5-5.1 hours	Zanamivir has limited plasma protein binding (<10%).	It is excreted unchanged in the urine with excretion of a single dose completed within 24 hours. Unabsorbed drug is excreted in the feces.Zanamivir is renally excreted as unchanged drug.	null	* 2.5 - 10.9 L/h [Following oral inhalation 10 mg] * 5.3 L/h [Normal renal function receiving IV single dose of 4 mg or 2 mg] * 2.7 L/h [Patients with mild and moderate renal impairement receiving IV single dose of 4 mg or 2 mg] * 0.8 L/h [Patients with severe renal impairement receiving IV single dose of 4 mg or 2 mg]	Organic compounds	Organic acids and derivatives	Carboxylic acids and derivatives	Carboxylic acid derivatives	[ "approved", "investigational" ]	[ "J05AH", "J05A", "J05", "J" ]	[ "Influenza A virus", "Influenza B virus" ]	[ { "cost": "3.54", "description": "Relenza 5 mg diskhaler", "unit": "each" }, { "cost": "75.73", "description": "Relenza Diskhaler 20 5 mg/blister Aerosol Inhaler", "unit": "inhaler" } ]	[ { "approved": "2001-09-25", "country": "United States", "expires": "2014-12-15", "number": "6294572" }, { "approved": "1994-11-01", "country": "United States", "expires": "2013-07-26", "number": "5360817" }, { "approved": "2003-10-14", "country": "Canada", "expires": "2011-04-24", "number": "2291994" }, { "approved": "2000-02-22", "country": "Canada", "expires": "2011-04-24", "number": "2081356" } ]	(2R,3R,4S)-3-(acetylamino)-4-carbamimidamido-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid \| 4-guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid \| 4-guanidino-Neu5Ac2en \| 5-(acetylamino)-2,6-anhydro-4-carbamimidamido-3,4,5-trideoxy-D-glycero-D-galacto-non-2-enonic acid \| 5-acetamido-2,6-anhydro-3,4,5-trideoxy-4-guanidino-D-glycero-D-galacto-non-2-enonic acid \| GANA \| Zanamivir \| 3.2.1.18 \| 3.2.1.18 \| 3.2.1.18 \| Cytosolic sialidase \| N-acetyl-alpha-neuraminidase 2	[ "Dectova", "Relenza", "Relenza", "Relenza", "Relenza" ]	[]	[]	[ "Q9Y3R4" ]	[]	[]	[]
DB00559	Bosentan	Bosentan is a dual endothelin receptor antagonist marketed under the trade name Tracleer by Actelion Pharmaceuticals. Bosentan is used to treat pulmonary hypertension by blocking the action of endothelin molecules that would otherwise promote narrowing of the blood vessels and lead to high blood pressure.	solid	Used in the treatment of pulmonary arterial hypertension (PAH), to improve exercise ability and to decrease the rate of clinical worsening (in patients with WHO Class III or IV symptoms).	Bosentan belongs to a class of drugs known as endothelin receptor antagonists (ERAs). Patients with PAH have elevated levels of endothelin, a potent blood vessel constrictor, in their plasma and lung tissue. Bosentan blocks the binding of endothelin to its receptors, thereby negating endothelin's deleterious effects.	Endothelin-1 (ET-1) is a neurohormone, the effects of which are mediated by binding to ET<sub>A</sub> and ET<sub>B</sub> receptors in the endothelium and vascular smooth muscle. It displays a slightly higher affinity towards ET<sub>A</sub> receptors than ET<sub>B</sub> receptors. ET-1 concentrations are elevated in plasma and lung tissue of patients with pulmonary arterial hypertension, suggesting a pathogenic role for ET-1 in this disease. Bosentan is a specific and competitive antagonist at endothelin receptor types ET<sub>A</sub> and ET<sub>B</sub>.	Absolute bioavailability is approximately 50% and food does not affect absorption.	Bosentan is metabolized in the liver by the cytochrome P450 enzymes CYP2C9 and CYP3A4 (and possibly CYP2C19), producing three metabolites, one of which, Ro 48-5033, is pharmacologically active and may contribute 10 to 20% to the total activity of the parent compound.	Bosentan has been given as a single dose of up to 2400 mg in normal volunteers, or up to 2000 mg/day for 2 months in patients, without any major clinical consequences. The most common side effect was headache of mild to moderate intensity. In the cyclosporine A interaction study, in which doses of 500 and 1000 mg b.i.d. of bosentan were given concomitantly with cyclosporine A, trough plasma concentrations of bosentan increased 30-fold, resulting in severe headache, nausea, and vomiting, but no serious adverse events. Mild decreases in blood pressure and increases in heart rate were observed. There is no specific experience of overdosage with bosentan beyond the doses described above. Massive overdosage may result in pronounced hypotension requiring active cardiovascular support.	Terminal elimination half-life is about 5 hours in healthy adult subjects.	Greater than 98% to plasma proteins, mainly albumin.	Bosentan is eliminated by biliary excretion following metabolism in the liver.	* 18 L	* 4 L/h [patients with pulmonary arterial hypertension]	Organic compounds	Organoheterocyclic compounds	Diazines	Pyrimidines and pyrimidine derivatives	[ "approved", "investigational" ]	[ "G01AE", "G01A", "G01", "G", "C02KX", "C02K", "C02", "C" ]	[ "Humans and other mammals" ]	[]	[ { "approved": "1998-08-25", "country": "Canada", "expires": "2012-06-12", "number": "2071193" }, { "approved": "1994-03-08", "country": "United States", "expires": "2015-11-20", "number": "5292740" }, { "approved": "2011-06-14", "country": "United States", "expires": "2027-12-28", "number": "7959945" }, { "approved": "2012-11-13", "country": "United States", "expires": "2026-05-15", "number": "8309126" } ]	4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-yl) benzenesulfornamide \| bosentán \| Bosentan \| bosentan anhydrous \| bosentanum \| p-tert-Butyl-N-(6-(2-hydroxyethoxy)-5-(o-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl)benzenesulfonamide \| Endothelin receptor non-selective type \| ET-B \| ET-BR \| ETRB \| Endothelin receptor type A \| ET-A \| ETA \| ETA-R \| ETRA \| hET-AR \| 1,4-cineole 2-exo-monooxygenase \| 1,8-cineole 2-exo-monooxygenase \| 1.14.14.1 \| Albendazole monooxygenase (sulfoxide-forming) \| Albendazole sulfoxidase \| Cholesterol 25-hydroxylase \| CYP3A3 \| CYPIIIA3 \| CYPIIIA4 \| Cytochrome P450 3A3 \| Cytochrome P450 HLp \| Cytochrome P450 NF-25 \| Cytochrome P450-PCN1 \| Nifedipine oxidase \| Quinine 3-monooxygenase \| (R)-limonene 6-monooxygenase \| (S)-limonene 6-monooxygenase \| (S)-limonene 7-monooxygenase \| 1.14.14.1 \| Cholesterol 25-hydroxylase \| CYP2C10 \| CYPIIC9 \| Cytochrome P-450MP \| Cytochrome P450 MP-4 \| Cytochrome P450 MP-8 \| Cytochrome P450 PB-1 \| S-mephenytoin 4-hydroxylase \| 7.6.2.- \| ATP-binding cassette sub-family B member 11 \| BSEP	[ "Accel-bosentan", "Act Bosentan", "Act Bosentan", "Alembic-bosentan", "Alembic-bosentan", "Apo-bosentan", "Apo-bosentan", "Auro-bosentan", "Auro-bosentan", "Bio-bosentan", "Bio-bosentan", "Bosentan", "Bosentan", "Bosentan", "Bosentan", "Bosentan", "Bosentan", "Bosentan", "Bosentan", "Bosentan", "Bosentan", "Bosentan", "Bosentan", "Bosentan", "Bosentan", "Bosentan", "Bosentan", "Bosentan", "Bosentan", "Bosentan", "Bosentan", "Bosentan", "Bosentan", "Bosentan", "Bosentan", "Bosentan", "Bosentan", "Bosentan", "Bosentan", "Bosentan", "Bosentan", "Bosentan Tablets", "Mar-bosentan", "Mar-bosentan", "Mylan-bosentan", "Mylan-bosentan", "Nat-bosentan", "Nat-bosentan", "PMS-bosentan", "PMS-bosentan", "Sandoz Bosentan", "Sandoz Bosentan", "Stayveer", "Stayveer", "Stayveer", "Stayveer", "Stayveer", "Stayveer", "Taro-bosentan", "Taro-bosentan", "Teva-bosentan", "Teva-bosentan", "Tracleer", "Tracleer", "Tracleer", "Tracleer", "Tracleer", "Tracleer", "Tracleer", "Tracleer", "Tracleer", "Tracleer", "Tracleer", "Tracleer", "Tracleer", "Tracleer" ]	[]	[]	[ "P24530", "P25101" ]	[ "P08684", "P11712" ]	[]	[ "O95342" ]
DB00561	Doxapram	A central respiratory stimulant with a brief duration of action. (From Martindale, The Extra Pharmocopoeia, 30th ed, p1225)	solid	For use as a temporary measure in hospitalized patients with acute respiratory insufficiency superimposed on chronic obstructive pulmonary disease.	Doxapram is an analeptic agent (a stimulant of the central nervous system). The respiratory stimulant action is manifested by an increase in tidal volume associated with a slight increase in respiratory rate. A pressor response may result following doxapram administration. Provided there is no impairment of cardiac function, the pressor effect is more marked in hypovolemic than in normovolemic states. The pressor response is due to the improved cardiac output rather than peripheral vasoconstriction. Following doxapram administration, an increased release of catecholamines has been noted.	Doxapram produces respiratory stimulation mediated through the peripheral carotid chemoreceptors. It is thought to stimulate the carotid body by inhibiting certain potassium channels.	null	null	Intravenous LD<sub>50</sub> values in the mouse and rat were approximately 75 mg/kg and in the cat and dog were 40 to 80 mg/kg. Symptoms of overdosage are extensions of the pharmacologic effects of the drug. Excessive pressor effect, tachycardia, skeletal muscle hyperactivity, and enhanced deep tendon reflexes may be early signs of overdosage.	null	null	null	null	null	Organic compounds	Benzenoids	Benzene and substituted derivatives	Diphenylmethanes	[ "approved", "vet_approved" ]	[ "R07AB", "R07A", "R07", "R" ]	[ "Humans and other mammals" ]	[ { "cost": "2.52", "description": "Dopram 20 mg/ml vial", "unit": "ml" }, { "cost": "4.67", "description": "Doxapram hcl 20 mg/ml vial", "unit": "ml" } ]	[]	(±)-doxapram \| 1-ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-2-pyrrolidinone \| Doxapram \| Doxapramum \| Acid-sensitive potassium channel protein TASK-1 \| TASK \| TASK1 \| TWIK-related acid-sensitive K(+) channel 1 \| Two pore K(+) channel KT3.1 \| Two pore potassium channel KT3.1 \| Acid-sensitive potassium channel protein TASK-3 \| TASK3 \| TWIK-related acid-sensitive K(+) channel 3 \| Two pore K(+) channel KT3.2 \| Two pore potassium channel KT3.2	[ "Dopram", "Dopram", "Dopram Inj 20mg/ml", "Dopram Injectable Liq 20mg/ml", "Doxapram Hydrochloride", "Doxapram Hydrochloride" ]	[ "Caropram", "Dai Er Song", "Jia Su Lun", "Stimulex", "Ze Lun" ]	[]	[ "O14649", "Q9NPC2" ]	[]	[]	[]
DB00562	Benzthiazide	Benzthiazide is used to treat hypertension and edema. Like other thiazides, benzthiazide promotes water loss from the body (diuretics). They inhibit Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used to treat hypertension, but their hypotensive effects are not necessarily due to their diuretic activity. Thiazides have been shown to prevent hypertension-related morbidity and mortality although the mechanism is not fully understood. Thiazides cause vasodilation by activating calcium-activated potassium channels (large conductance) in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue.	solid	For the treatment of high blood pressure and management of edema.	Benzthiazide is used to treat hypertension and edema. Like other thiazides, benzthiazide promotes water loss from the body (diuretics). They inhibit Na<sup>+</sup>/Cl<sup>-</sup> reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used to treat hypertension, but their hypotensive effects are not necessarily due to their diuretic activity. Thiazides have been shown to prevent hypertension-related morbidity and mortality although the mechanism is not fully understood. Thiazides cause vasodilation by activating calcium-activated potassium channels (large conductance) in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue.	As a diuretic, benzthiazide inhibits active chloride reabsorption at the early distal tubule via the Na-Cl cotransporter, resulting in an increase in the excretion of sodium, chloride, and water. Thiazides like benzthiazide also inhibit sodium ion transport across the renal tubular epithelium through binding to the thiazide sensitive sodium-chloride transporter. This results in an increase in potassium excretion via the sodium-potassium exchange mechanism. The antihypertensive mechanism of benzthiazide is less well understood although it may be mediated through its action on carbonic anhydrases in the smooth muscle or through its action on the large-conductance calcium-activated potassium (KCa) channel, also found in the smooth muscle.	Absorbed in the digestive tract.	null	Symptoms of overdose include nausea, vomiting, fatigue, urinary problems and drowsiness.	null	30%	null	null	null	Organic compounds	Organoheterocyclic compounds	Thiadiazines	Benzothiadiazines	[ "approved" ]	[ "G01AE", "G01A", "G01", "G" ]	[ "Humans and other mammals" ]	[]	[]	3-((benzylthio)methyl)-6-chloro-7-sulfamoyl-2H-benzo-1,2,4-thiadiazine 1,1-dioxide \| 3-benzylthiomethyl-6-chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide \| 3-benzylthiomethyl-6-chloro-7-sulfamoyl-1,2,4-benzothiadiazine 1,1-dioxide \| 6-chloro-1,1-dioxo-3-(phenylmethylsulfanylmethyl)-4H-benzo[e][1,2,4]thiadiazine-7-sulfonamide \| 6-chloro-7-sulfamoyl-3-benzylthiomethyl-2H-1,2,4-benzothiadiazine 1,1-dioxide \| Benzothiazide \| Benzotiazida \| Benzthiazid \| Benzthiazide \| Benzthiazidum \| Benztiazide \| Na-Cl cotransporter \| Na-Cl symporter \| NCC \| Thiazide-sensitive sodium-chloride cotransporter \| TSC \| 4.2.1.1 \| CA-I \| CAB \| Carbonate dehydratase I \| Carbonic anhydrase B \| Carbonic anhydrase I \| Cyanamide hydratase CA1 \| 4.2.1.1 \| CA-XIII \| Carbonate dehydratase XIII \| Carbonic anhydrase XIII \| 4.2.1.1 \| CA-XIV \| Carbonate dehydratase XIV \| Carbonic anhydrase XIV \| 4.2.1.1 \| CA-II \| CAC \| Carbonate dehydratase II \| Carbonic anhydrase C \| Carbonic anhydrase II \| Cyanamide hydratase CA2 \| 4.2.1.1 \| CA-III \| Carbonate dehydratase III \| Carbonic anhydrase III \| 4.2.1.1 \| CA-IV \| Carbonate dehydratase IV \| Carbonic anhydrase IV \| 4.2.1.1 \| CA-VA \| CA5 \| Carbonate dehydratase VA \| Carbonic anhydrase VA \| 4.2.1.1 \| CA-VB \| Carbonate dehydratase VB \| Carbonic anhydrase VB \| 4.2.1.1 \| CA-VI \| Carbonate dehydratase VI \| Carbonic anhydrase VI \| Salivary carbonic anhydrase \| Secreted carbonic anhydrase \| 4.2.1.1 \| CA-VII \| Carbonate dehydratase VII \| Carbonic anhydrase VII \| 4.2.1.1 \| CA-IX \| CAIX \| Carbonate dehydratase IX \| Carbonic anhydrase IX \| G250 \| Membrane antigen MN \| MN \| P54/58N \| pMW1 \| RCC-associated antigen G250 \| Renal cell carcinoma-associated antigen G250 \| 4.2.1.1 \| CA-II \| CAC \| Carbonate dehydratase II \| Carbonic anhydrase C \| Carbonic anhydrase II \| Cyanamide hydratase CA2 \| 4.2.1.1 \| CA-I \| CAB \| Carbonate dehydratase I \| Carbonic anhydrase B \| Carbonic anhydrase I \| Cyanamide hydratase CA1 \| 4.2.1.1 \| CA-IV \| Carbonate dehydratase IV \| Carbonic anhydrase IV \| 4.2.1.1 \| CA-IX \| CAIX \| Carbonate dehydratase IX \| Carbonic anhydrase IX \| G250 \| Membrane antigen MN \| MN \| P54/58N \| pMW1 \| RCC-associated antigen G250 \| Renal cell carcinoma-associated antigen G250 \| 4.2.1.1 \| CA-XII \| Carbonate dehydratase XII \| Carbonic anhydrase XII \| Tumor antigen HOM-RCC-3.1.3	[]	[ "Aquatag", "Dihydrex", "Diucen", "Edemax", "Exna", "Foven" ]	[]	[ "P55017", "P00915", "Q8N1Q1", "Q9ULX7", "P00918", "P07451", "P22748", "P35218", "Q9Y2D0", "P23280", "P43166", "Q16790", "P00918", "P00915", "P22748", "Q16790", "O43570" ]	[]	[]	[]
DB00564	Carbamazepine	Carbamazepine, also known as Tegretol, is an anticonvulsant drug and analgesic drug used to control seizures and to treat pain resulting from trigeminal neuralgia. It was initially approved by the FDA in 1965.[A180301] Aside from the above uses, this drug is also given to control the symptoms of bipolar 1.[L1335] Interestingly, carbamazepine was the first anticonvulsant used to treat individuals with bipolar disorder.[A180319]	solid	Carbamazepine is indicated for the treatment of epilepsy and pain associated with true trigeminal neuralgia.[L1335] In particular, carbamazepine has shown efficacy in treating mixed seizures, partial seizures with complex symptoms, and generalized tonic-clonic seizures.[A180301,L1335] Carbamazepine is also indicated for the treatment of manic episodes and mixed manic-depressive episodes caused by bipolar I disorder.[L1335] Some off-label, unapproved uses of carbamazepine include the treatment of alcohol withdrawal syndrome and restless leg syndrome.[A180415,A180421]	General effects Carbamazepine treats seizures and the symptoms of trigeminal neuralgia by inhibiting sodium channels. In bipolar 1 disorder, carbamazepine has been found to decrease mania symptoms in a clinically significant manner according to the Young Mania Rating Scale (YMRS).[L1335] Carbamazepine has a narrow therapeutic index.[A180301] A note on genetic variation and carbamazepine use In studies of Han Chinese ancestry patients, a pronounced association between the HLA-B*1502 genotype and Steven Johnson syndrome and/or toxic epidermal necrolysis (SJS/TEN) resulting from carbamazepine use was observed.[A180397]	Carbamazepine's mechanism of action is not fully elucidated and is widely debated.[A180310,L9713] One major hypothesis is that carbamazepine inhibits sodium channel firing, treating seizure activity. Animal research studies have demonstrated that carbamazepine exerts its effects by lowering polysynaptic nerve response and inhibiting post-tetanic potentiation. In both cats and rats, carbamazepine was shown to decrease pain caused by infraorbital nerve stimulation. A decrease in the action potential in the nucleus ventralis of the thalamus in the brain and inhibition of the lingual mandibular reflex were observed in other studies after carbamazepine use. Carbamazepine causes the above effects by binding to voltage-dependent sodium channels and preventing action potentials, which normally lead to stimulatory effects on nerves.[A180403,T634] In bipolar disorder, carbamazepine is thought to increase dopamine turnover and increase GABA transmission, treating manic and depressive symptoms.[L7216] A common issue that has arisen is resistance to this drug in up to 30% of epileptic patients, which may occur to altered metabolism in patients with variant genotypes.[A180436] A potential therapeutic target to combat carbamazepine resistance has recently been identified as the EPHX1 gene promoter, potentially conferring resistance to carbamazepine through methylation.[A180439]	The bioavailability of carbamazepine is in the range of 75-85% of an ingested dose.[A180301] After one 200 mg oral extended-release dose of carbamazepine in a pharmacokinetic study, the Cmax carbamazepine was measured to be 1.9 ± 0.3 mcg/mL. The Tmax was 19 ± 7 hours. After several doses of 800 mg every 12 hours, the peak concentrations of carbamazepine were measured to be 11.0 ± 2.5 mcg/mL. The Tmax was reduced to 5.9 ± 1.8 hours. Extended-release carbamazepine demonstrated linear pharmacokinetics over a range of 200–800 mg.[L1335] Effect of food on absorption A meal containing high-fat content increased the rate of absorption of one 400 mg dose but not the AUC of carbamazepine.[L1335] The elimination half-life remained unchanged between fed and fasting state. The pharmacokinetics of an extended-release carbamazepine dose was demonstrated to be similar when administered in the fasted state or with food.[L1335] Based on these findings, food intake is unlikely to exert significant effects on carbamazepine absorption.	Carbamazepine is largely metabolized in the liver. CYP3A4 hepatic enzyme is the major enzyme that metabolizes carbamazepine to its active metabolite, carbamazepine-10,11-epoxide[A180427], which is further metabolized to its trans-diol form by the enzyme epoxide hydrolase.[L1335] Other hepatic cytochrome enzymes that contribute to the metabolism of carbamazepine are CYP2C8, CYP3A5, and CYP2B6.[L7195] Carbamazepine also undergoes hepatic glucuronidation by UGT2B7 enzyme and several other metabolic reactions occur, resulting in the formation of minor hydroxy metabolites and quinone metabolites.[L7195] Interestingly, carbamazepine induces its own metabolism.[L1335] This leads to enhanced clearance, reduced half-life, and a reduction in serum levels of carbamazepine.[A180301,L1335]	Toxicity information Oral LDLO (female): 1920 mg/kg/17W (intermittent); Oral LDLO (male): 54 mg/kg/9D (intermittent)[L7156] Oral LD50 (rat): 1957 mg/kg [L7156] Overdose information The initial signs of carbamazepine overdose occur 1-3 hours post ingestion. These signs and symptoms may vary in case of an overdose between carbamazepine and other drugs. Carbamazepine may cause various cardiovascular, neurological, respiratory, urinary symptoms as well as laboratory abnormalities including leukocytosis, reduced leucocytes, acetonuria, and glycosuria.[L1335] Neuromuscular symptoms may occur initially, followed by mild cardiac symptoms such as tachycardia, hypertension, or hypotension. Higher doses of carbamazepine may cause more severed cardiovascular effects. Restlessness, muscular twitching, tremor, dilated pupils, nystagmus, psychomotor disturbances, and other neurological symptoms may occur. Hyperreflexia in the initial stages of overdose may be followed by hyporeflexia. Nausea, vomiting, urinary retention, dizziness or drowsiness may also occur.[L1335] In cases of overdose, contact the local poison control center. Ensure to provide supportive and symptomatic treatment, which may include monitoring and careful supervision by a medical professional. The possibility of overdose with multiple drugs must be considered in the case of carbamazepine overdose. Maintain an adequate airway, oxygen, in addition to ventilation. Vital signs should be monitored.[L1335]	The mean elimination half-life of carbamazepine was 35 to 40 hours after one dose of carbamazepine extended-release formulations. The half-life ranged from 12-17 hours after several doses of carbamazepine.[L1335] One pharmacokinetic study determined the elimination half-life of carbamazepine to range between 27 to 36.8 hours in healthy volunteers.[A180424]	Carbamazepine is 75%-80% bound to plasma proteins.[A180301,L1335] One pharmacokinetic study indicates that it is 72% bound to plasma proteins.[A180424]	After an oral dose of radiolabeled carbamazepine, 72% of the administered radioactive dose was detected in the urine and the remainder of the ingested dose was found in the feces. Carbamazepine is mainly excreted as hydroxylated and conjugated metabolites, and minimal amounts of unchanged drug.[L1335]	The volume of distribution of carbamazepine was found to be 1.0 L/kg in one pharmacokinetic study.[A180304] Another study indicates that the volume of distribution of carbamazepine ranges between 0.7 to 1.4 L/kg.[A180424]. Carbamazepine crosses the placenta, and higher concentrations of this drug are found in the liver and kidney as opposed to lung and brain tissue.[L1335] Carbamazepine crosses variably through the blood-brain barrier.[A180436]	In a pharmacokinetic study, the apparent oral clearance of carbamazepine was 25 ± 5 mL/min [A180424,L1335] after one dose of carbamazepine and 80 ± 30 mL/min after several doses.[L1335]	Organic compounds	Organoheterocyclic compounds	Benzazepines	Dibenzazepines	[ "approved", "investigational" ]	[ "N03AF", "N03A", "N03", "N" ]	[ "Humans and other mammals" ]	[ { "cost": "1.03", "description": "CarBAMazepine 200 mg 12 Hour tablet", "unit": "tablet" }, { "cost": "1.1", "description": "Tegretol xr 200 mg tablet", "unit": "tablet" }, { "cost": "1.45", "description": "TEGretol XR 200 mg 12 Hour tablet", "unit": "tablet" }, { "cost": "1.74", "description": "Equetro 100 mg capsule", "unit": "capsule" }, { "cost": "1.84", "description": "Carbatrol er 100 mg capsule", "unit": "capsule" }, { "cost": "1.84", "description": "Carbatrol er 200 mg capsule", "unit": "capsule" }, { "cost": "1.84", "description": "Carbatrol er 300 mg capsule", "unit": "capsule" }, { "cost": "1.92", "description": "Carbatrol 200 mg 12 Hour Capsule", "unit": "capsule" }, { "cost": "1.95", "description": "Carbatrol 300 mg 12 Hour Capsule", "unit": "capsule" }, { "cost": "2.05", "description": "CarBAMazepine 400 mg 12 Hour tablet", "unit": "tablet" }, { "cost": "2.15", "description": "Equetro 200 mg capsule", "unit": "capsule" }, { "cost": "2.18", "description": "Carbatrol 100 mg 12 Hour Capsule", "unit": "capsule" }, { "cost": "2.19", "description": "Tegretol xr 400 mg tablet", "unit": "tablet" }, { "cost": "2.26", "description": "Carbamazepine powder", "unit": "g" }, { "cost": "2.42", "description": "TEGretol XR 400 mg 12 Hour tablet", "unit": "tablet" }, { "cost": "2.65", "description": "Equetro 300 mg capsule", "unit": "capsule" }, { "cost": "0.08", "description": "Apo-Carbamazepine 200 mg Tablet", "unit": "tablet" }, { "cost": "0.08", "description": "Novo-Carbamaz 200 mg Tablet", "unit": "tablet" }, { "cost": "0.08", "description": "Nu-Carbamazepine 200 mg Tablet", "unit": "tablet" }, { "cost": "0.08", "description": "Pms-Carbamazepine 100 mg Chewable Tablet", "unit": "tablet" }, { "cost": "0.08", "description": "Sandoz Carbamazepine 100 mg Chewable Tablet", "unit": "tablet" }, { "cost": "0.08", "description": "Taro-Carbamazepine 100 mg Chewable Tablet", "unit": "tablet" }, { "cost": "0.08", "description": "Tegretol 20 mg/ml Suspension", "unit": "ml" }, { "cost": "0.16", "description": "CarBAMazepine 100 mg/5ml Suspension", "unit": "ml" }, { "cost": "0.16", "description": "Pms-Carbamazepine 200 mg Chewable Tablet", "unit": "tablet" }, { "cost": "0.16", "description": "Sandoz Carbamazepine 200 mg Chewable Tablet", "unit": "tablet" }, { "cost": "0.16", "description": "Taro-Carbamazepine 200 mg Chewable Tablet", "unit": "tablet" }, { "cost": "0.17", "description": "Tegretol 100 mg Chewable Tablet", "unit": "tablet" }, { "cost": "0.2", "description": "Mylan-Carbamazepine Cr 200 mg Sustained-Release Tablet", "unit": "tablet" }, { "cost": "0.2", "description": "Pms-Carbamazepine-Cr 200 mg Sustained-Release Tablet", "unit": "tablet" }, { "cost": "0.2", "description": "Sandoz Carbamazepine Cr 200 mg Sustained-Release Tablet", "unit": "tablet" }, { "cost": "0.25", "description": "CarBAMazepine 100 mg Chew Tabs", "unit": "tab" }, { "cost": "0.3", "description": "Epitol 200 mg tablet", "unit": "tablet" }, { "cost": "0.31", "description": "Carbamazepine 200 mg tablet", "unit": "tablet" }, { "cost": "0.34", "description": "Tegretol 200 mg Chewable Tablet", "unit": "tablet" }, { "cost": "0.4", "description": "Mylan-Carbamazepine Cr 400 mg Sustained-Release Tablet", "unit": "tablet" }, { "cost": "0.4", "description": "Pms-Carbamazepine-Cr 400 mg Sustained-Release Tablet", "unit": "tablet" }, { "cost": "0.4", "description": "Sandoz Carbamazepine Cr 400 mg Sustained-Release Tablet", "unit": "tablet" }, { "cost": "0.42", "description": "Tegretol Cr 200 mg Sustained-Release Tablet", "unit": "tablet" }, { "cost": "0.55", "description": "Tegretol xr 100 mg tablet", "unit": "tablet" }, { "cost": "0.75", "description": "Tegretol 200 mg tablet", "unit": "tablet" }, { "cost": "0.84", "description": "Tegretol Cr 400 mg Sustained-Release Tablet", "unit": "tablet" }, { "cost": "0.97", "description": "TEGretol XR 100 mg 12 Hour tablet", "unit": "tablet" } ]	[ { "approved": "1994-02-08", "country": "United States", "expires": "2011-02-08", "number": "5284662" }, { "approved": "1999-06-15", "country": "United States", "expires": "2016-06-15", "number": "5912013" }, { "approved": "2005-12-20", "country": "United States", "expires": "2024-05-19", "number": "6977253" }, { "approved": "2009-12-22", "country": "United States", "expires": "2029-03-13", "number": "7635773" }, { "approved": "2013-04-02", "country": "United States", "expires": "2029-03-13", "number": "8410077" }, { "approved": "2016-11-15", "country": "United States", "expires": "2033-02-27", "number": "9493582" }, { "approved": "2017-04-25", "country": "United States", "expires": "2028-11-10", "number": "9629797" }, { "approved": "2017-09-26", "country": "United States", "expires": "2028-11-10", "number": "9770407" }, { "approved": "2017-09-05", "country": "United States", "expires": "2029-03-13", "number": "9750822" }, { "approved": "2020-01-31", "country": "United States", "expires": "2040-01-31", "number": "11529357" } ]	5-Carbamoyl-5H-dibenz(b,f)azepine \| 5-carbamoyl-5H-dibenz[b,f]azepine \| 5-Carbamoyl-5H-dibenzo(b,f)azepine \| 5-Carbamyl-5H-dibenzo(b,f)azepine \| 5H-Dibenz(b,f)azepine-5-carboxamide \| Carbamazepen \| Carbamazepin \| Carbamazepina \| Carbamazépine \| Carbamazepine \| Carbamazepinum \| CBZ \| Molecusol-Carbamazepine \| NAC1 \| SCN1 \| Sodium channel protein brain I subunit alpha \| Sodium channel protein type I subunit alpha \| Voltage-gated sodium channel subunit alpha Nav1.1 \| hPN3 \| Peripheral nerve sodium channel 3 \| PN3 \| Sodium channel protein type X subunit alpha \| Voltage-gated sodium channel subunit alpha Nav1.8 \| hNaN \| Peripheral nerve sodium channel 5 \| PN5 \| SCN12A \| Sensory neuron sodium channel 2 \| SNS2 \| Sodium channel protein type XI subunit alpha \| Voltage-gated sodium channel subunit alpha Nav1.9 \| HBA \| HBSC II \| NAC2 \| SCN2A1 \| SCN2A2 \| Sodium channel protein brain II subunit alpha \| Sodium channel protein type II subunit alpha \| Voltage-gated sodium channel subunit alpha Nav1.2 \| KIAA1356 \| NAC3 \| Sodium channel protein brain III subunit alpha \| Sodium channel protein type III subunit alpha \| Voltage-gated sodium channel subtype III \| Voltage-gated sodium channel subunit alpha Nav1.3 \| SkM1 \| Sodium channel protein skeletal muscle subunit alpha \| Sodium channel protein type IV subunit alpha \| Voltage-gated sodium channel subunit alpha Nav1.4 \| hH1 \| Sodium channel protein cardiac muscle subunit alpha \| Sodium channel protein type V subunit alpha \| Voltage-gated sodium channel subunit alpha Nav1.5 \| Atypical sodium channel Nav2.1 \| Nax channel \| SCN6A \| Sodium channel protein type VII subunit alpha \| MED \| Sodium channel protein type VIII subunit alpha \| Voltage-gated sodium channel subunit alpha Nav1.6 \| hNE-Na \| NENA \| Neuroendocrine sodium channel \| Peripheral sodium channel 1 \| PN1 \| Sodium channel protein type IX subunit alpha \| Voltage-gated sodium channel subunit alpha Nav1.7 \| NACRA4 \| Orphan nuclear receptor PAR1 \| Orphan nuclear receptor PXR \| Pregnane X receptor \| PXR \| Steroid and xenobiotic receptor \| SXR \| 1,4-cineole 2-exo-monooxygenase \| 1,8-cineole 2-exo-monooxygenase \| 1.14.14.1 \| Albendazole monooxygenase (sulfoxide-forming) \| Albendazole sulfoxidase \| Cholesterol 25-hydroxylase \| CYP3A3 \| CYPIIIA3 \| CYPIIIA4 \| Cytochrome P450 3A3 \| Cytochrome P450 HLp \| Cytochrome P450 NF-25 \| Cytochrome P450-PCN1 \| Nifedipine oxidase \| Quinine 3-monooxygenase \| 1.14.14.1 \| CYPIIC8 \| Cytochrome P450 form 1 \| Cytochrome P450 IIC2 \| Cytochrome P450 MP-12 \| Cytochrome P450 MP-20 \| S-mephenytoin 4-hydroxylase \| 1.14.14.1 \| Cholesterol 25-hydroxylase \| CYPIA2 \| Cytochrome P(3)450 \| Cytochrome P450 4 \| Cytochrome P450-P3 \| Hydroperoxy icosatetraenoate dehydratase \| (R)-limonene 6-monooxygenase \| (S)-limonene 6-monooxygenase \| (S)-limonene 7-monooxygenase \| 1.14.14.1 \| Cholesterol 25-hydroxylase \| CYP2C10 \| CYPIIC9 \| Cytochrome P-450MP \| Cytochrome P450 MP-4 \| Cytochrome P450 MP-8 \| Cytochrome P450 PB-1 \| S-mephenytoin 4-hydroxylase \| (R)-limonene 6-monooxygenase \| (S)-limonene 6-monooxygenase \| (S)-limonene 7-monooxygenase \| 1.14.14.1 \| CYPIIC17 \| CYPIIC19 \| Cytochrome P450-11A \| Cytochrome P450-254C \| Fenbendazole monooxygenase (4'-hydroxylating) \| Mephenytoin 4-hydroxylase \| 1,4-cineole 2-exo-monooxygenase \| 1.14.13.- \| CYPIIB6 \| Cytochrome P450 IIB1 \| 1.14.14.1 \| CYPIIIA5 \| Cytochrome P450-PCN3 \| 2.4.1.17 \| 3,4-catechol estrogen-specific UDPGT \| UDP-glucuronosyltransferase 2B9 \| UDPGT 2B7 \| UDPGT 2B9 \| UDPGTh-2 \| UGT2B7 \| UGTB2B9 \| 2.4.1.17 \| Bilirubin-specific UDPGT isozyme 1 \| GNT1 \| hUG-BR1 \| UDP-glucuronosyltransferase 1-1 \| UDP-glucuronosyltransferase 1A isoform 1 \| UDPGT 1-1 \| UGT1 \| UGT1-01 \| UGT1.1 \| UGT11 \| UGT1A1 \| 2.4.1.17 \| GNT1 \| Phenol-metabolizing UDP-glucuronosyltransferase \| UDP-glucuronosyltransferase 1-F \| UDP-glucuronosyltransferase 1A6 \| UDPGT 1-6 \| UGT-1F \| UGT1 \| UGT1-06 \| UGT1.6 \| UGT16 \| UGT1F \| 2.4.1.17 \| GNT1 \| UDP-glucuronosyltransferase 1-7 \| UDP-glucuronosyltransferase 1-G \| UDPGT 1-7 \| UGT-1G \| UGT1 \| UGT1-07 \| UGT1.7 \| UGT1*7 \| UGT1A7 \| UGT1G \| ATP-binding cassette sub-family B member 1 \| MDR1 \| Multidrug resistance protein 1 \| P-glycoprotein 1 \| PGY1 \| Phospholipid transporter ABCB1 \| 76 kDa Ral-interacting protein \| Dinitrophenyl S-glutathione ATPase \| DNP-SG ATPase \| Ral-interacting protein 1 \| RalBP1 \| RLIP \| RLIP1 \| RLIP76 \| 7.6.2.- \| 7.6.2.2 \| 7.6.2.3 \| Canalicular multidrug resistance protein \| Canalicular multispecific organic anion transporter 1 \| CMOAT \| CMOAT1 \| CMRP \| MRP2 \| Multidrug resistance-associated protein 2	[ "Apo-carbamazepine", "Apo-carbamazepine CR", "Apo-carbamazepine CR", "Bio-carbamazepine", "Carbamazepin", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine", "Carbamazepine (Chewable)", "Carbamazepine 200 Tab 200mg", "Carbamazepine 200mg Tablets", "Carbamazepine CR", "Carbamazepine CR", "Carbamazepine ER", "Carbamazepine ER", "Carbamazepine ER", "Carbamazepine ER", "Carbamazepine ER", "Carbamazepine ER", "Carbamazepine ER", "Carbamazepine ER", "Carbamazepine ER", "Carbamazepine ER", "Carbamazepine ER", "Carbamazepine ER", "Carbamazepine ER", "Carbamazepine ER", "Carbamazepine ER", "Carbamazepine ER", "Carbamazepine ER", "Carbamazepine ER", "Carbamazepine ER", "Carbamazepine ER", "Carbamazepine ER", "Carbamazepine ER", "Carbamazepine ER", "Carbamazepine ER", "Carbamazepine ER", "Carbamazepine-CR -(200mg)", "Carbamazepine-CR -(400mg)", "CarbamazepineER ER", "Carbatrol", "Carbatrol", "Carbatrol", "Carbatrol", "Carnexiv", "Dom-carbamazepine", "Dom-carbamazepine CR", "Dom-carbamazepine CR", "Epitol", "Equetro", "Equetro", "Equetro", "Equetro", "Equetro", "Equetro", "Mazepine", "Mint-carbamazepine", "Mylan-carbamazepine CR", "Mylan-carbamazepine CR", "Nu-carbamazepine Tab 200mg", "PHL-carbamazepine CR", "PHL-carbamazepine CR", "PMS-carbamazepine", "PMS-carbamazepine", "PMS-carbamazepine", "PMS-carbamazepine", "PMS-carbamazepine CR", "PMS-carbamazepine CR", "PMS-carbamazepine-CR", "PMS-carbamazepine-CR", "Sandoz-carbamazepine Chewtabs", "Sandoz-carbamazepine Chewtabs", "Sandoz-carbamazepine CR", "Sandoz-carbamazepine CR", "Taro-carbamazepine", "Taro-carbamazepine", "Taro-carbamazepine Chewable Tablets", "Taro-carbamazepine Chewable Tablets", "Taro-carbamazepine CR", "Taro-carbamazepine CR", "Taro-carbamazepine Tab 200mg", "Tegretol", "Tegretol", "Tegretol", "Tegretol", "Tegretol", "Tegretol", "Tegretol", "Tegretol", "Tegretol", "Tegretol", "Tegretol", "Tegretol - XR", "Tegretol - XR", "Tegretol - XR", "Tegretol Chewtabs 100 mg", "Tegretol Chewtabs 200 mg", "Tegretol CR", "Tegretol CR", "Tegretol Suspension", "Tegretol XR", "Tegretol XR", "Tegretol XR", "Tegretol XR", "Tegretol XR", "Tegretol XR", "Tegretol XR", "Tegretol XR", "Tegretol XR", "TegretolXR XR", "Teva-carbamazepine" ]	[ "Actebral", "Anleptic", "Biston", "Carbamat", "Neurotop", "TEGretol Chewtabs", "TEGretol-CR", "TEGretol-XR", "Teril", "Timonil", "Versitol", "Versizur" ]	[]	[ "P35498", "Q9Y5Y9", "Q9UI33", "Q99250", "Q9NY46", "P35499", "Q14524", "Q01118", "Q9UQD0", "Q15858", "P43681", "O75469" ]	[ "P08684", "P10632", "P05177", "P11712", "P33261", "P20813", "P20815", "P16662", "P22309", "P19224", "Q9HAW7" ]	[]	[ "P08183", "Q15311", "Q92887" ]
DB00776	Oxcarbazepine	Oxcarbazepine is an anti-epileptic medication used in the treatment of partial onset seizures that was first approved for use in the United States in 2000.[L8627,L8630,L8633] It is a structural derivative of [carbamazepine][A186101] and exerts a majority of its activity via a pharmacologically active metabolite, MHD, which exists as a racemate in the blood - a pro-drug of the more active (S)-enantiomer is also marketed as a separate anti-epileptic under the name [eslicarbazepine].[A186011] Compared to other anti-epileptic drugs, which are generally metabolized via the cytochrome P450 system, oxcarbazepine has a reduced propensity for involvement in drug-drug interactions owing to its primarily reductive metabolism.[A186032]	solid	In the United States, oxcarbazepine is indicated for use as monotherapy or adjunctive therapy in the treatment of partial-onset seizures in adults and as monotherapy in the treatment of partial-onset seizures in pediatric patients aged 4 years and above, and as adjunctive therapy in pediatric patients aged 2 years and above with partial-onset seizures.[L8627] In Canada, oxcarbazepine is indicated for use as monotherapy or adjunctive therapy in the treatment of partial-onset seizures in patients 6 years of age and older.[L8630]	Oxcarbazepine is an anticonvulsant drug that reduces the incidence of seizures in epilepsy by inhibiting abnormal electrical activity in the brain.[L8627,L8630,L8633] There have been rare reports of oxcarbazepine resulting in the development of hematologic abnormalities, including agranulocytosis and aplastic anemia. Patients should be undergo frequent laboratory testing and should be monitored closely for signs and symptoms of blood dyscrasias. Oxcarbazepine has also been associated with the development of dermatologic reactions which can progress from a simple rash to potentially fatal reactions such as toxic epidermal necrolysis (TEN) or Stevens-Johnson Syndrome (SJS). Patients with the HLA-A 3101 and/or HLA-B 1502 alleles may be at higher risk of this reaction. Oxcarbazepine should be discontinued at the first sign of a drug-induced skin reaction.[L8627,L8630,L8633]	The exact mechanism through which oxcarbazepine and its active metaoblite, MHD, exert their anti-epileptic effects is unclear, but is thought to primarily involve the blockade of voltage-gated sodium channels.[L8627,L8630,L8633,A186104] The opening and closing of sodium channels allows for the propagation of action potentials along neurons - in epilepsy, these action potentials can occur in excess of that required for normal function, and the repetitive and pathological firing of these action potentials leads to seizure activity. Both oxcarbazepine and MHD are thought to inhibit seizure activity by binding to the inactive state of voltage-gated sodium channels, thus prolonging the period in which the receptor is unavailable for action potential propagation.[A186101] This helps to stabilize hyperexcited neuronal membranes, inhibit repetitive neuron firing, and prevent the spread of seizure activity within the CNS without affecting normal neuronal transmission.[L8627,L8630,L8633] Increased potassium conductance and modulation of voltage-activated calcium channels is also thought to play a role in the anti-seizure activity of oxcarbazepine.[L8627,L8630,L8633] Inhibition of glutamatergic activity was thought to contribute to oxcarbazepine's activity[A34516], but this effect could not be replicated _in vivo_.[A186104]	Oxcarbazepine is completely absorbed following oral administration. A single 600mg dose of oxcarbazepine resulted in an MHD C<sub>max</sub> of 34 μmol/L and a median T<sub>max</sub> of 4.5 hours.[L8627,L8630,L8633] When administered twice daily, steady-state levels of MHD are attained within 2-3 days. The rate and extent of absorption of oxcarbazepine is not affected by food intake.[L8627,L8630,L8633]	Oxcarbazepine is rapidly and extensively metabolized to its primary metabolite, MHD, which is responsible for the bulk of its anti-epileptic activity and exists in much higher concentrations in the plasma than the parent drug.[L8627,L8630,L8633] MHD is formed via reduction by several members of the aldo-keto reductase family of cytosolic liver enzymes and exists as a racemate in plasma in an approximate ratio of 80% (S)-MHD to 20% (R)-MHD.[A186011] MHD is further metabolized to glucuronide conjugate metabolites for excretion, and small amounts are oxidized to 10-,11-dihydro-10,11-dihydroxycarbamazepine (DHD) which is pharmacologically inactive.[L8627,L8630,L8633,A186020] Only 10% of an administered dose of oxcarbazepine will remain as either the parent drug or glucuronide conjugates of the parent drug.[A186026]	The oral LD<sub>50</sub> of oxcarbazepine in mammals is 1240 mg/kg and the oral TDLo in children has been reported to be 73 mg/kg.[L8672] Isolated cases of oxcarbazepine overdose have been reported - patients who ingested up to 24,000mg recovered with symptomatic treatment.[L8627,L8630] Symptoms may include respiratory and CNS depression, movement-related disorders (e.g. dyskinesia, ataxia), nausea/vomiting, hyponatremia, or QTc prolongation. There is no antidote for oxcarbazepine overdose - management should consist of supportive and symptomatic treatment, and consideration should be given to the use of gastric lavage or activated charcoal.[L8627,L8630]	The plasma half-life of oxcarbazepine is approximately 2 hours and the plasma half-life of MHD is approximately 9 hours.[L8627,L8630,L8633]	The pharmacologically active metabolite of oxcarbazepine, MHD, is approximately 40% bound to plasma proteins, predominantly albumin.[L8627,L8630,L8633]	Following oral administration, more than 95% of the administered dose of oxcarbazepine is found in the urine. Of this, approximately 49% is MHD glucuronide metabolites, 27% is unchanged MHD, 3% is inactive DHD metabolites, 13% is conjugated oxcarbazepine, and less than 1% is unchanged parent drug. Fecal elimination accounts for only 4% of the administered dose.[L8627,L8630,L8633]	The apparent volume of distribution of oxcarbazepine is 49 L.[L8627,L8630,L8633] The apparent volumes of distribution of (S)- and (R)-MHD were found to be 23.6 L and 31.7 L, respectively.[A186026]	Plasma clearance of oxcarbazepine has been estimated to be approximately 84.9 L/h, whereas plasma clearance of its active metabolite, MHD, was estimated to be 2.0 L/h.[A186026] Rapid metabolic clearance appears to be the main pathway for oxcarbazepine, while clearance of its metabolites occurs mainly via renal excretion.[A186032]	Organic compounds	Organoheterocyclic compounds	Benzazepines	Dibenzazepines	[ "approved" ]	[ "N03AF", "N03A", "N03", "N" ]	[ "Humans and other mammals" ]	[ { "cost": "1.53", "description": "Oxcarbazepine 150 mg tablet", "unit": "tablet" }, { "cost": "2.1", "description": "Trileptal 150 mg tablet", "unit": "tablet" }, { "cost": "2.75", "description": "Oxcarbazepine 300 mg tablet", "unit": "tablet" }, { "cost": "3.84", "description": "Trileptal 300 mg tablet", "unit": "tablet" }, { "cost": "5.06", "description": "Oxcarbazepine 600 mg tablet", "unit": "tablet" }, { "cost": "7.05", "description": "Trileptal 600 mg tablet", "unit": "tablet" }, { "cost": "162.03", "description": "OXcarbazepine 300 mg/5ml Suspension 250ml Bottle", "unit": "bottle" }, { "cost": "0.79", "description": "Trileptal 300 mg/5ml Suspension", "unit": "ml" } ]	[ { "approved": "2008-11-18", "country": "Canada", "expires": "2018-02-12", "number": "2277791" }, { "approved": "2006-05-02", "country": "United States", "expires": "2018-08-12", "number": "7037525" }, { "approved": "2012-02-21", "country": "United States", "expires": "2021-06-19", "number": "8119148" }, { "approved": "2011-03-22", "country": "United States", "expires": "2027-04-13", "number": "7910131" }, { "approved": "2015-09-01", "country": "United States", "expires": "2027-04-13", "number": "9119791" }, { "approved": "2014-09-02", "country": "United States", "expires": "2027-04-13", "number": "8821930" }, { "approved": "2013-12-31", "country": "United States", "expires": "2027-04-13", "number": "8617600" }, { "approved": "2010-05-25", "country": "United States", "expires": "2027-04-13", "number": "7722898" }, { "approved": "2016-06-21", "country": "United States", "expires": "2027-04-13", "number": "9370525" }, { "approved": "2016-05-31", "country": "United States", "expires": "2027-04-13", "number": "9351975" }, { "approved": "2018-01-02", "country": "United States", "expires": "2027-04-13", "number": "9855278" }, { "approved": "2019-03-05", "country": "United States", "expires": "2027-04-13", "number": "10220042" }, { "approved": "2021-11-09", "country": "United States", "expires": "2027-04-13", "number": "11166960" }, { "approved": "2007-04-13", "country": "United States", "expires": "2027-04-13", "number": "11896599" } ]	10,11-Dihydro-10-oxo-5H-dibenz(b,f)azepine-5-carboxamide \| OCBZ \| Oxcarbamazepine \| Oxcarbazepina \| Oxcarbazepine \| Oxcarbazepinum \| hNaN \| Peripheral nerve sodium channel 5 \| PN5 \| SCN12A \| Sensory neuron sodium channel 2 \| SNS2 \| Sodium channel protein type XI subunit alpha \| Voltage-gated sodium channel subunit alpha Nav1.9 \| NAC1 \| SCN1 \| Sodium channel protein brain I subunit alpha \| Sodium channel protein type I subunit alpha \| Voltage-gated sodium channel subunit alpha Nav1.1 \| hPN3 \| Peripheral nerve sodium channel 3 \| PN3 \| Sodium channel protein type X subunit alpha \| Voltage-gated sodium channel subunit alpha Nav1.8 \| hNaN \| Peripheral nerve sodium channel 5 \| PN5 \| SCN12A \| Sensory neuron sodium channel 2 \| SNS2 \| Sodium channel protein type XI subunit alpha \| Voltage-gated sodium channel subunit alpha Nav1.9 \| HBA \| HBSC II \| NAC2 \| SCN2A1 \| SCN2A2 \| Sodium channel protein brain II subunit alpha \| Sodium channel protein type II subunit alpha \| Voltage-gated sodium channel subunit alpha Nav1.2 \| KIAA1356 \| NAC3 \| Sodium channel protein brain III subunit alpha \| Sodium channel protein type III subunit alpha \| Voltage-gated sodium channel subtype III \| Voltage-gated sodium channel subunit alpha Nav1.3 \| SkM1 \| Sodium channel protein skeletal muscle subunit alpha \| Sodium channel protein type IV subunit alpha \| Voltage-gated sodium channel subunit alpha Nav1.4 \| hH1 \| Sodium channel protein cardiac muscle subunit alpha \| Sodium channel protein type V subunit alpha \| Voltage-gated sodium channel subunit alpha Nav1.5 \| Atypical sodium channel Nav2.1 \| Nax channel \| SCN6A \| Sodium channel protein type VII subunit alpha \| MED \| Sodium channel protein type VIII subunit alpha \| Voltage-gated sodium channel subunit alpha Nav1.6 \| hNE-Na \| NENA \| Neuroendocrine sodium channel \| Peripheral sodium channel 1 \| PN1 \| Sodium channel protein type IX subunit alpha \| Voltage-gated sodium channel subunit alpha Nav1.7 \| KIAA1158 \| 1.1.1.- \| 1.1.1.112 \| 1.1.1.209 \| 1.1.1.210 \| 1.1.1.357 \| 1.1.1.51 \| 1.1.1.53 \| 1.1.1.62 \| 1.3.1.20 \| 20-alpha-HSD \| 20-alpha-hydroxysteroid dehydrogenase \| Chlordecone reductase homolog HAKRC \| DD1 \| DDH \| DDH1 \| Dihydrodiol dehydrogenase 1 \| HBAB \| High-affinity hepatic bile acid-binding protein \| 1.-.-.- \| 1.1.1.112 \| 1.1.1.209 \| 1.1.1.53 \| 1.1.1.62 \| 1.3.1.20 \| 3-alpha-HSD3 \| Chlordecone reductase homolog HAKRD \| DD-2 \| DD/BABP \| DD2 \| DDH2 \| Dihydrodiol dehydrogenase 2 \| Dihydrodiol dehydrogenase/bile acid-binding protein \| Type III 3-alpha-hydroxysteroid dehydrogenase \| 1.1.1.- \| 1.1.1.210 \| 1.1.1.53 \| 1.1.1.62 \| 17-beta-HSD 5 \| 17-beta-hydroxysteroid dehydrogenase type 5 \| 3-alpha-HSD type 2 \| 3-alpha-HSD type II, brain \| 3-alpha-hydroxysteroid dehydrogenase type 2 \| Chlordecone reductase homolog HAKRb \| DD-3 \| DD3 \| DDH1 \| Dihydrodiol dehydrogenase 3 \| Dihydrodiol dehydrogenase type I \| HA1753 \| HSD17B5 \| KIAA0119 \| PGFS \| Prostaglandin F synthase \| Testosterone 17-beta-dehydrogenase 5 \| 1.1.1.- \| 1.1.1.209 \| 1.1.1.210 \| 1.1.1.51 \| 1.1.1.53 \| 1.1.1.62 \| 3-alpha-HSD1 \| 3-alpha-hydroxysteroid dehydrogenase type I \| 3alpha-hydroxysteroid 3-dehydrogenase \| CDR \| CHDR \| Chlordecone reductase \| DD-4 \| DD4 \| Dihydrodiol dehydrogenase 4 \| HAKRA \| 1.1.1.184 \| 15-hydroxyprostaglandin dehydrogenase [NADP(+)] \| 20-beta-hydroxysteroid dehydrogenase \| Alcohol dehydrogenase [NAD(P)+] CBR1 \| CBR \| CRN \| NADPH-dependent carbonyl reductase 1 \| PG-9-KR \| Prostaglandin 9-ketoreductase \| Prostaglandin-E(2) 9-reductase \| SDR21C1 \| Short chain dehydrogenase/reductase family 21C member 1 \| 1.1.1.184 \| NADPH-dependent carbonyl reductase 3 \| Quinone reductase CBR3 \| SDR21C2 \| Short chain dehydrogenase/reductase family 21C member 2 \| (R)-limonene 6-monooxygenase \| (S)-limonene 6-monooxygenase \| (S)-limonene 7-monooxygenase \| 1.14.14.1 \| CYPIIC17 \| CYPIIC19 \| Cytochrome P450-11A \| Cytochrome P450-254C \| Fenbendazole monooxygenase (4'-hydroxylating) \| Mephenytoin 4-hydroxylase \| 1,4-cineole 2-exo-monooxygenase \| 1,8-cineole 2-exo-monooxygenase \| 1.14.14.1 \| Albendazole monooxygenase (sulfoxide-forming) \| Albendazole sulfoxidase \| Cholesterol 25-hydroxylase \| CYP3A3 \| CYPIIIA3 \| CYPIIIA4 \| Cytochrome P450 3A3 \| Cytochrome P450 HLp \| Cytochrome P450 NF-25 \| Cytochrome P450-PCN1 \| Nifedipine oxidase \| Quinine 3-monooxygenase \| 1.14.14.1 \| CYPIIIA5 \| Cytochrome P450-PCN3 \| ATP-binding cassette sub-family B member 1 \| MDR1 \| Multidrug resistance protein 1 \| P-glycoprotein 1 \| PGY1 \| Phospholipid transporter ABCB1	[ "Apo-oxcarbazepine", "Apo-oxcarbazepine", "Apo-oxcarbazepine", "Jamp-oxcarbazepine", "Jamp-oxcarbazepine", "Jamp-oxcarbazepine", "Novo-oxcarbazepine", "Novo-oxcarbazepine", "Novo-oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxcarbazepine", "Oxtellar XR", "Oxtellar XR", "Oxtellar XR", "Sandoz Oxcarbazepine", "Sandoz Oxcarbazepine", "Sandoz Oxcarbazepine", "Trileptal", "Trileptal", "Trileptal", "Trileptal", "Trileptal", "Trileptal", "Trileptal", "Trileptal", "Trileptal", "Trileptal", "Trileptal", "Trileptal", "Trileptal 150 mg", "Trileptal 300 mg", "Trileptal 600 mg", "Trileptal Oral Suspension" ]	[ "Actinium", "Barzepin", "Carbox", "Deprectal", "Lonazet", "Oxalepsy", "Oxetol", "Oxpin", "Oxrate", "Oxypine", "Pharozepine", "Prolepsi", "Timox", "Trexapin", "Trileptin" ]	[]	[ "Q9UI33", "P35498", "Q9Y5Y9", "Q9UI33", "Q99250", "Q9NY46", "P35499", "Q14524", "Q01118", "Q9UQD0", "Q15858", "Q07699", "O60939", "Q9NY72", "Q8IWT1" ]	[ "Q04828", "P52895", "P42330", "P17516", "P16152", "O75828", "P33261", "P08684", "P20815" ]	[ "P02768" ]	[ "P08183" ]
DB00565	Cisatracurium	Cisatracurium is a non-depolarising neuromuscular blocking agent of the benzylisoquinolinium class, available in its salt form, cisatracurium besylate.[A243416,A253592] Cisatracurium has an intermediate duration of action and is one of the most commonly used neuromuscular blocking agents in intensive care.[A253592,A253597]. Cisatracurium acts on cholinergic receptors, blocking neuromuscular transmission. This action is antagonized by acetylcholinesterase inhibitors such as neostigmine.[A243416,A253592] Cisatracurium is an R-cis-R-cis isomer of [atracurium] and has approximately 3 times its neuromuscular blocking potency.[A243416] Compared to atracurium, cisatracurium produces a lower degree of histamine release.[A253597]	solid	Cisatracurium is indicated as an adjunct to general anesthesia to facilitate tracheal intubation in adults and pediatric patients 1 month to 12 years of age. Cisatracurium is also indicated to provide skeletal muscle relaxation during surgery in adults and pediatric patients 2 to 12 years of age as a bolus or infusion maintenance and for mechanical ventilation in the ICU in adults.[L43577]	The dose required to produce 95% suppression of twitch response to nerve stimulation (ED<sub>95</sub>) of cisatracurium is 0.05 mg/kg in adults receiving opioid/nitrous oxide/oxygen anesthesia.[A253597,L43577] The degree and duration of the neuromuscular block produced by cisatracurium increases in a dose-dependent manner, while the time to maximum neuromuscular block decreases.[A253597] Compared to other neuromuscular blocking agents, it is intermediate in its onset and duration of action.[A253592] Cisatracurium acts on cholinergic receptors, blocking neuromuscular transmission. This action is antagonized by acetylcholinesterase inhibitors such as neostigmine.[A243416] The use of cisatracurium may lead to residual paralysis, as well as a higher risk of seizure. Medication errors increase the risk of death, and the use of certain drugs may potentiate the neuromuscular blocking action of cisatracurium.[L43577]	Like other non-depolarising neuromuscular blocking agents, cisatracurium binds competitively to cholinergic receptors in motor end-plate neurons, blocking acetylcholine from accessing the receptors.[L43577] Therefore, in the presence of cisatracurium, an end-plate potential cannot be developed. Ion channels remain closed, the cell does not depolarize, and an action potential is not transmitted.[A243416]	The pharmacokinetics of cisatracurium follow a two-compartment open model.[A253602,L43577] Cisatracurium is metabolized into laudanosine and monoquaternary alcohol metabolite (MQA). Following the IV infusion of cisatracurium, the C<sub>max</sub> of laudanosine and MQA were 6% and 11% of the parent compound, respectively.[L43577] Compared to young patients, the volume of distribution of cisatracurium is slightly larger in elderly patients, which also leads to longer half-life values. The plasma clearance of cisatracurium was not affected by age. Patients with hepatic impairment have a slightly higher volume of distribution and plasma clearance values; however, these minor pharmacokinetic differences are not considered clinically significant. Additionally, the pharmacokinetic parameters of cisatracurium in patients with end-stage renal disease were similar to those detected in healthy adult patients.[L43577]	The degradation of cisatracurium is largely independent of liver metabolism. Cisatracurium undergoes Hofmann elimination (a pH and temperature-dependent chemical process) to form laudanosine and the monoquaternary acrylate metabolite. Non-specific plasma esterases hydrolyze the monoquaternary acrylate metabolite to form the monoquaternary alcohol metabolite (MQA). The MQA can also undergo Hofmann elimination, but the rate of this process is slower than the one detected for cisatracurium. Laudanosine is further metabolized to desmethyl metabolites that are conjugated with glucuronic acid and excreted in the urine. Laudanosine may cause transient hypotension and, in higher doses, cerebral excitatory effects when administered to several animal species; however, the effects of laudanosine in humans have not been established.[L43577]	Overdosage with neuromuscular blocking agents such as cisatracurium may result in neuromuscular block beyond the time needed for surgery and anesthesia. Maintenance of a patent airway and controlled ventilation until recovery of normal neuromuscular function is the primary treatment for overdose cases. To facilitate further recovery, a cholinesterase inhibitor in conjunction with an appropriate cholinergic inhibitor may be administered once recovery from the neuromuscular block begins. If complete neuromuscular blockade is evident or suspected, cholinesterase inhibitors should not be administered. The reversal of paralysis may not be sufficient to maintain a patent airway and an appropriate level of spontaneous ventilation.[L43577] The long-term carcinogenicity of cisatracurium has not been evaluated. In an _in vitro_ mouse lymphoma forward gene mutation assay, cisatracurium besylate led to mutations in the presence and absence of exogenous metabolic activation. Other assays did not show evidence of mutagenicity or clastogenicity.[L43577]	Cisatracurium has an elimination half-life of 22 minutes.[L43577]	The binding of cisatracurium to plasma proteins has not been successfully studied due to its rapid degradation at physiologic pH.[L43577]	The predominant elimination mechanism of cisatracurium is Hofmann elimination, a chemical process dependent on pH and temperature (approximately 80% in healthy surgical patients). The liver and kidney play a minor role in the elimination of cisatracurium (about 20%); however, they have a significant role in the metabolism of cisatracurium metabolites.[L43577] In healthy male patients (n=6) given <sup>14</sup>C-cisatracurium, 4% of the recovered dose was found in feces, and 95% was found in urine, mostly as conjugated metabolites. Less than 10% of the cisatracurium dose was excreted as the unchanged patent drug. In another group of patients with Foley catheters for surgical management given non-radiolabeled cisatracurium (n=12), 15% of the cisatracurium dose was excreted unchanged in urine.[L43577]	Cisatracurium has a volume of distribution at steady state of 145 mL/kg.[L43577] The volume of distribution of cisatracurium besylate is small due to its relatively large molecular weight and high polarity.[A253602]	Cisatracurium has a plasma clearance of 4.57 mL/min/kg.[L43577]	Organic compounds	Organoheterocyclic compounds	Isoquinolines and derivatives	Benzylisoquinolines	[ "approved", "investigational" ]	[ "M03AC", "M03A", "M03", "M" ]	[ "Humans and other mammals" ]	[ { "cost": "2.91", "description": "Nimbex 2 mg/ml vial", "unit": "ml" }, { "cost": "13.8", "description": "Nimbex 10 mg/ml vial", "unit": "ml" } ]	[ { "approved": "1995-09-26", "country": "United States", "expires": "2012-09-26", "number": "5453510" }, { "approved": "1998-08-18", "country": "Canada", "expires": "2011-07-12", "number": "2087104" } ]	(1r,2r,1'r,2'r)-2,2'-{pentane-1,5-diylbis[oxy(3-oxopropane-3,1-diyl)]}bis[1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolinium] \| Cisatracurium cation \| Cisatracurium ion \| NACHR alpha-10 \| NACHRA10 \| Nicotinic acetylcholine receptor subunit alpha-10 \| NACHRA3 \| NACRA4 \| NACHRA5 \| NACHRA7 \| NACHR alpha-9 \| NACHRA9 \| Nicotinic acetylcholine receptor subunit alpha-9 \| ACHRA \| CHNRA	[ "Aj-cisatracurium", "Aj-cisatracurium", "Cisatracurium", "Cisatracurium", "Cisatracurium", "Cisatracurium Besylate", "Cisatracurium Besylate", "Cisatracurium Besylate", "Cisatracurium Besylate", "Cisatracurium Besylate", "Cisatracurium Besylate", "Cisatracurium Besylate", "Cisatracurium Besylate", "Cisatracurium Besylate", "Cisatracurium Besylate", "Cisatracurium Besylate", "Cisatracurium Besylate", "Cisatracurium Besylate", "Cisatracurium Besylate", "Cisatracurium Besylate", "Cisatracurium Besylate", "Cisatracurium Besylate", "Cisatracurium Besylate", "Cisatracurium Besylate", "Cisatracurium Besylate", "Cisatracurium Besylate", "Cisatracurium Besylate", "Cisatracurium Besylate", "Cisatracurium Besylate", "Cisatracurium Besylate", "Cisatracurium Besylate", "Cisatracurium Besylate", "Cisatracurium Besylate", "Cisatracurium Besylate", "Cisatracurium Besylate", "Cisatracurium Besylate", "Cisatracurium Besylate", "Cisatracurium Besylate", "Cisatracurium Besylate", "Cisatracurium Besylate", "Cisatracurium Besylate", "Cisatracurium Besylate", "Cisatracurium Besylate", "Cisatracurium Besylate", "Cisatracurium Besylate", "Cisatracurium besylate", "Cisatracurium besylate", "Cisatracurium Besylate", "Cisatracurium Besylate", "Cisatracurium Besylate", "Cisatracurium Besylate", "Cisatracurium besylate", "Cisatracurium besylate", "Cisatracurium besylate", "Cisatracurium Besylate", "Cisatracurium Besylate", "Cisatracurium besylate", "Cisatracurium besylate", "Cisatracurium besylate", "Cisatracurium Besylate Injection", "Cisatracurium Besylate Injection", "Cisatracurium Besylate Injection", "Cisatracurium Besylate Injection (preservative-free)", "Cisatracurium Besylate Injection Multi-dose", "Cisatracurium Besylate Injection Single Dose", "Cisatracurium Besylate Injection USP Multidose", "Cisatracurium Omega Single Dose", "Nimbex", "Nimbex", "Nimbex", "Nimbex", "Nimbex 10mg/ml" ]	[ "Nimbex", "Nimbex Preservative Free", "Nimbium" ]	[]	[ "Q15822", "Q9GZZ6", "Q15822", "P32297", "P43681", "P30532", "Q15825", "P36544", "Q9UGM1", "P17787", "Q05901", "P30926", "P02708", "P08172" ]	[]	[]	[]
DB00566	Succimer	A mercaptodicarboxylic acid used as an antidote to heavy metal poisoning because it forms strong chelates with them.	solid	For the treatment of lead poisoning in pediatric patients with blood lead levels above 45 µg/dL. May also be used to treat mercury or arsenic poisoning.	Succimer is an orally active, heavy metal chelating agent. It forms water soluble chelates and, consequently, increases the urinary excretion of lead. Succimer is not to be used for prophylaxis of lead poisoning in a lead-containing environment. In addition, the use of succimer should always be accompanied by identification and removal of the source of the lead exposure.	Succimer is a heavy metal chelator. It binds with high specificity to ions of lead in the blood to form a water-soluble complex that is subsequently excreted by the kidneys. Succimer can also chelate mercury, cadmium, and arsenic in this manner.	Rapid but variable.	Chemical analysis of succimer and its metabolites (primarily mixed disulfides of L-cysteine) in the urine showed that succimer was rapidly and extensively metabolized however the specific site of biotransformation is not known.	Oral LD<sub>50</sub> in mice is over 5011 mg/kg. Doses of 2300 mg/kg in the rat and 2400 mg/kg in the mouse produced ataxia, convulsions, labored respiration and frequently death. No case of overdosage has been reported in humans. Limited data indicate that succimer is dialyzable.	48 hours	null	Unabsorbed drug is excreted primarily in feces and absorbed drug is excreted primarily in the urine as metabolites.	null	null	Organic compounds	Lipids and lipid-like molecules	Fatty Acyls	Fatty acids and conjugates	[ "approved" ]	[]	[ "Humans and other mammals" ]	[ { "cost": "8.6", "description": "Chemet 100 mg capsule", "unit": "capsule" }, { "cost": "15.61", "description": "Dmsa powder", "unit": "g" } ]	[]	DIM-SA \| DMS \| DMS-A \| DMSA \| meso-2,3-Dimercaptobernsteinsäure \| meso-2,3-dimercaptosuccinic acid \| meso-dimercaptosuccinic acid \| Succimer \| succimero	[ "Chemet", "Chemet", "NephroScan" ]	[]	[]	[]	[]	[]	[]
DB00567	Cephalexin	Cephalexin is the first of the first generation cephalosporins.[A179071,A179074] This antibiotic contains a beta lactam and a dihydrothiazide.[A179071] Cephalexin is used to treat a number of susceptible bacterial infections through inhibition of cell wall synthesis.[A179083,Label] Cephalexin was approved by the FDA on 4 January 1971.[L6547]	solid	Cephalexin is indicated for the treatment of certain infections caused by susceptible bacteria.[Label,L6550,L6553] These infections include respiratory tract infections, otitis media, skin and skin structure infections, bone infections, and genitourinary tract infections.[Label,L6550,L6553]	Cephalexin (also called Cefalexin) is a first generation cephalosporin antibiotic.[A179071,A179074] It is one of the most widely prescribed antibiotics, often used for the treatment of superficial infections that result as complications of minor wounds or lacerations.[Label] It is effective against most gram-positive bacteria through its inihibition of the cross linking reaction between N-acetyl muramicacid and N-acetylglucosamine in the cell wall, leading to cell lysis.[A179083]	Cephalexin is a first generation cephalosporin antibiotic.[A179071,A179074] Cephalosporins contain a beta lactam and dihydrothiazide.[A179071] Unlike penicillins, cephalosprins are more resistant to the action of beta lactamase.[A179071] Cephalexin inhibits bacterial cell wall synthesis, leading breakdown and eventualy cell death.[Label]	Well absorbed from the upper gastrointestinal tract with nearly 100% oral bioavailability.[A179032,A179035] Cephalexin is not absorbed in the stomach but is absorbed in the upper intestine.[A179065] Patients taking 250mg of cephalexin reach a maximum plasma concentration of 7.7mcg/mL and patients taking 500mg reach 12.3mcg/mL.[A179026]	Cephalexin is not metabolized in the body.[A179029,Label,L6550,L6553]	Symptoms of overdose include blood in the urine, diarrhea, nausea, upper abdominal pain, and vomiting.[Label] An overdose is generally managed through supportive treatment as diuresis, dialysis, hemodialysis, and charcoal hemoperfusion are not well studied in this case.[Label] The oral median lethal dose of cephalexin in rats is >5000 mg/kg. The oral LD50 in a monkey is >1g/kg and the lowest dose causing a toxic effect in humans is 14mg/kg.[MSDS] Cephalexin has not been shown to be harmful in pregnancy and is not associated with teratogeniticy.[Label] Cephalexin is present in breast milk, though infants may be exposed to <1% of the dose given to the mother.[Label] The effects of breast milk exposure to cephalexin have not been established and so caution must be exercised and the risk and benefit of cephalexin use in breastfeeding must be weighed.[Label] Cephalexin has not been studied for carcinogenicity or mutagenicity.[Label] Cephalexin has no affect on fertility in rats.[Label]	The half life of cephalexin is 49.5 minutes in a fasted state and 76.5 minutes with food though these times were not significantly different in the study.[A179032]	Cephalexin is 10-15% bound to serum proteins[Label,L6550] including serum albumin.[A179053]	Cephalexin is over 90% excreted in the urine after 6 hours[A179026] by glomerular filtration and tubular secretion[Label,L6550,L6553] with a mean urinary recovery of 99.3%.[A179032] Cephalexin is unchanged in the urine.[A179026,A179029,A179032]	5.2-5.8L.[A179068]	Clearance from one subject was 376mL/min.[A179032]	Organic compounds	Organoheterocyclic compounds	Lactams	Beta lactams	[ "approved", "investigational", "vet_approved" ]	[ "J01DB", "J01D", "J01", "J" ]	[ "Enteric bacteria and other eubacteria" ]	[ { "cost": "1.17", "description": "Cephalexin 250 mg tablet", "unit": "tablet" }, { "cost": "1.4", "description": "Cephalexin 500 mg capsule", "unit": "capsule" }, { "cost": "1.85", "description": "Keflex 250 mg pulvule", "unit": "each" }, { "cost": "2.2", "description": "Keflex 250 mg capsule", "unit": "capsule" }, { "cost": "2.25", "description": "Cephalexin 500 mg tablet", "unit": "tablet" }, { "cost": "3.34", "description": "Keflex 750 mg capsule", "unit": "capsule" }, { "cost": "4.99", "description": "Keflex 500 mg pulvule", "unit": "each" }, { "cost": "5.75", "description": "Keflex 500 mg capsule", "unit": "capsule" }, { "cost": "15.99", "description": "Cephalexin 125 mg/5ml Suspension 100ml Bottle", "unit": "bottle" }, { "cost": "16.39", "description": "Cephalexin 125 mg/5ml Suspension 200ml Bottle", "unit": "bottle" }, { "cost": "19.66", "description": "Cephalexin 250 mg/5ml Suspension 100ml Bottle", "unit": "bottle" }, { "cost": "32.76", "description": "Cephalexin 250 mg/5ml Suspension 200ml Bottle", "unit": "bottle" }, { "cost": "0.09", "description": "Novo-Lexin 25 mg/ml Suspension", "unit": "ml" }, { "cost": "0.14", "description": "Novo-Lexin 50 mg/ml Suspension", "unit": "ml" }, { "cost": "0.24", "description": "Apo-Cephalex 250 mg Tablet", "unit": "tablet" }, { "cost": "0.24", "description": "Novo-Lexin 250 mg Capsule", "unit": "capsule" }, { "cost": "0.24", "description": "Novo-Lexin 250 mg Tablet", "unit": "tablet" }, { "cost": "0.24", "description": "Nu-Cephalex 250 mg Tablet", "unit": "tablet" }, { "cost": "0.47", "description": "Apo-Cephalex 500 mg Tablet", "unit": "tablet" }, { "cost": "0.47", "description": "Novo-Lexin 500 mg Capsule", "unit": "capsule" }, { "cost": "0.47", "description": "Novo-Lexin 500 mg Tablet", "unit": "tablet" }, { "cost": "0.47", "description": "Nu-Cephalex 500 mg Tablet", "unit": "tablet" }, { "cost": "0.72", "description": "Cephalexin 250 mg capsule", "unit": "capsule" } ]	[]	(6R,7R)-7-{[(2R)-2-amino-2-phenylacetyl]amino}-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid \| 7-(D-alpha-Aminophenylacetamido)desacetoxycephalosporanic acid \| 7-beta-(D-alpha-Amino-alpha-phenylacetylamino)-3-methyl-3-cephem-4-carboxylic acid \| Anhydrous cefalexin \| Anhydrous cephalexin \| Cefalexin \| Cefalexin anhydrous \| Cefalexina \| Céfalexine \| Cefalexinum \| Cephalexin anhydrous \| Putative D-alanyl-D-alanine carboxypeptidase \| pbp2b \| exp2 \| Exported protein 2 \| PBP-1A \| High-affinity sodium-dependent carnitine cotransporter \| OCTN2 \| Solute carrier family 22 member 5 \| Intestinal H(+)/peptide cotransporter \| Oligopeptide transporter, small intestine isoform \| PEPT1 \| Peptide transporter 1 \| Kidney H(+)/peptide cotransporter \| Oligopeptide transporter, kidney isoform \| PEPT2 \| Peptide transporter 2 \| hOAT1 \| hPAHT \| hROAT1 \| OAT1 \| Organic anion transporter 1 \| PAH transporter \| PAHT \| Renal organic anion transporter 1 \| hMATE-1 \| MATE-1 \| MATE1 \| Solute carrier family 47 member 1 \| hOAT3 \| OAT3 \| Organic anion/dicarboxylate exchanger \| Solute carrier family 22 member 8	[ "Apo-cephalex", "Apo-cephalex", "Asn-cephalexin", "Asn-cephalexin", "Auro-cephalexin", "Auro-cephalexin", "Auro-cephalexin", "Auro-cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", 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"Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin", "Cephalexin Oral Susp", "Cephalexin Tab 250mg", "Cephalexin USP", "Cephalexin USP", "Cephalexin-500", "Daxbia", "Dom-cephalexin - Tab 250mg", "Dom-cephalexin - Tab 500mg", "Dom-cephalexin 125 - Sus 125mg/5ml", "Dom-cephalexin 250 - Sus 250mg/5ml", "Jamp Cephalexin", "Jamp Cephalexin", "Jamp Cephalexin Suspension", "Jamp Cephalexin Suspension", "Keflex", "Keflex", "Keflex", "Keflex", "Keflex", "Keflex", "Keflex", "Keflex", "Keflex", "Keflex", "Keflex", "Keflex", "Keflex", "Keflex", "Keflex", "Keflex", "Keflex", "Keflex", "Keflex", "Keflex", "Keflex", "Lupin-cephalexin", "Lupin-cephalexin", "Lupin-cephalexin", "Lupin-cephalexin", "Nu-cephalex Tab 250mg", "Nu-cephalex Tab 500mg", "Panixine Disperdose", "Panixine Disperdose", "Penta-cephalexin - 250mg", "Penta-cephalexin - 500mg", "PMS-cephalexin - Tab 250mg", "PMS-cephalexin - Tab 500mg", "PMS-cephalexin 125 - Sus 125mg/5ml", "PMS-cephalexin 250 - Sus 250mg/5ml", "Stcc-cephalexin -tab 250mg", "Stcc-cephalexin -tab 500mg", "Stcc-cephalexin 125 - Orl Sus 125mg/5ml", "Stcc-cephalexin 250 - Sus Orl 250mg/5ml", "Teva-cephalexin", "Teva-cephalexin", "Teva-cephalexin", "Teva-cephalexin", "Teva-cephalexin 125", "Teva-cephalexin 250" ]	[ "Alcephin", "Alexin", "Alsporin", "Cefadin", "Cefalin", "Ceforal", "Cefovit", "Celexin", "Cephin", "Ceporexin", "Felexin", "Ibilex", "Keforal", "L-Keflex", "Larixin", "Lonflex", "Madlexin", "Nufex", "Oriphex", "Ospexin", "Palitrex", "Pyassan", "Sanaxin", "Sencephalin", "Sepexin", "Servispor", "Sialexin", "Sporicef", "Sporidex", "Syncl", "Tepaxin", "Uphalexin", "Voxxim", "Winlex" ]	[]	[]	[]	[ "P02768" ]	[ "O76082", "P46059", "Q16348", "Q4U2R8", "Q96FL8", "Q8TCC7" ]
DB00568	Cinnarizine	First synthesized by Janssen Pharmaceuticals in 1955, cinnarizine is an anti-histaminic drug mainly used for the control of vestibular disorders and motion sickness. Cinnarizine is a specific calcium channel blocker that primarily works on the central vestibular system to interfere with the signal transmission between vestibular apparatus of the inner ear and the vomiting centre of the hypothalamus. Cinnarizine could be also viewed as a nootropic drug because of its vasorelaxating abilities (due to calcium channel blockage), which happen mostly in brain. Combination use of cinnarizine with other nootropics, such as [piracetam] resulted in enhanced effect of boosting brain oxygen supply.	solid	For the treatment of vertigo/meniere's disease, nausea and vomiting, motion sickness and also useful for vestibular symptoms of other origins.	Cinnarizine is an antihistamine and a calcium channel blocker. Histamines mediate a number of activities such as contraction of smooth muscle of the airways and gastrointestinal tract, vasodilatation, cardiac stimulation, secretion of gastric acid, promotion of interleukin release and chemotaxis of eosinophils and mast cells. Competitive antagonists at histamine H1 receptors may be divided into first (sedating) and second (non-sedating) generation agents. Some, such as Cinnarizine also block muscarinic acetylcholine receptors and are used as anti-emetic agents. Cinnarizine through its calcium channel blocking ability also inhibits stimulation of the vestibular system.	Cinnarizine inhibits contractions of vascular smooth muscle cells by blocking L-type and T-type voltage gated calcium channels. Cinnarizine has also been implicated in binding to dopamine D2 receptors, histamine H1 receptors, and muscarinic acetylcholine receptors.	null	null	null	null	null	null	null	null	null	null	null	null	[ "approved", "investigational" ]	[ "N07CA", "N07C", "N07", "N", "N07CA", "N07C", "N07", "N" ]	[ "Humans and other mammals" ]	[]	[]	1-(Diphenylmethyl)-4-(3-phenyl-2-propenyl)piperazine \| 1-Benzhydryl-4-cinnamylpiperazin \| 1-Cinnamyl-4-(diphenylmethyl)piperazine \| Cinarizina \| Cinnarizine \| Cinnarizinum \| H1-R \| H1R \| HH1R \| CACH2 \| CACN2 \| CACNL1A1 \| Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle \| CCHL1A1 \| Voltage-gated calcium channel subunit alpha Cav1.2 \| CACH3 \| CACN4 \| CACNL1A2 \| Calcium channel, L type, alpha-1 polypeptide, isoform 2 \| CCHL1A2 \| Voltage-gated calcium channel subunit alpha Cav1.3 \| CACNAF1 \| Voltage-gated calcium channel subunit alpha Cav1.4 \| CACH1 \| CACN1 \| CACNL1A3 \| Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle \| Voltage-gated calcium channel subunit alpha Cav1.1 \| Cav3.1c \| KIAA1123 \| NBR13 \| Voltage-gated calcium channel subunit alpha Cav3.1 \| Low-voltage-activated calcium channel alpha1 3.2 subunit \| Voltage-gated calcium channel subunit alpha Cav3.2 \| Ca(v)3.3 \| KIAA1120 \| Voltage-gated calcium channel subunit alpha Cav3.3 \| Dopamine D2 receptor \| Dopamine D1 receptor \| D(5) dopamine receptor \| D1beta dopamine receptor \| Dopamine D5 receptor \| DRD1B \| DRD1L2 \| 1.14.14.- \| Cholesterol 25-hydroxylase \| CYP2DL1 \| CYPIID6 \| Cytochrome P450-DB1 \| Debrisoquine 4-hydroxylase \| (R)-limonene 6-monooxygenase \| (S)-limonene 6-monooxygenase \| (S)-limonene 7-monooxygenase \| 1.14.14.1 \| Cholesterol 25-hydroxylase \| CYP2C10 \| CYPIIC9 \| Cytochrome P-450MP \| Cytochrome P450 MP-4 \| Cytochrome P450 MP-8 \| Cytochrome P450 PB-1 \| S-mephenytoin 4-hydroxylase \| 1.14.14.1 \| Cholesterol 25-hydroxylase \| CYPIA2 \| Cytochrome P(3)450 \| Cytochrome P450 4 \| Cytochrome P450-P3 \| Hydroperoxy icosatetraenoate dehydratase \| 1,4-cineole 2-exo-monooxygenase \| 1.14.13.- \| CYPIIB6 \| Cytochrome P450 IIB1 \| 1,4-cineole 2-exo-monooxygenase \| 1.14.14.- \| Coumarin 7-hydroxylase \| CYP2A3 \| CYPIIA6 \| Cytochrome P450 IIA3 \| Cytochrome P450(I) \| 1.14.14.1 \| CYPIA1 \| Cytochrome P450 form 6 \| Cytochrome P450-C \| Cytochrome P450-P1 \| Hydroperoxy icosatetraenoate dehydratase \| 1,4-cineole 2-exo-monooxygenase \| 1,8-cineole 2-exo-monooxygenase \| 1.14.14.1 \| Albendazole monooxygenase (sulfoxide-forming) \| Albendazole sulfoxidase \| Cholesterol 25-hydroxylase \| CYP3A3 \| CYPIIIA3 \| CYPIIIA4 \| Cytochrome P450 3A3 \| Cytochrome P450 HLp \| Cytochrome P450 NF-25 \| Cytochrome P450-PCN1 \| Nifedipine oxidase \| Quinine 3-monooxygenase	[]	[ "Cinazyn", "Cinnageron", "Folcodal", "Sepan", "Stugeron", "Stugeron Forte", "Toliman" ]	[]	[ "P35367", "Q13936", "Q01668", "O60840", "Q13698", "O43497", "O95180", "Q9P0X4", "P14416", "P21728", "P21918", "P11229", "P08172", "P20309", "P08173", "P08912" ]	[ "P10635", "P11712", "P05177", "P20813", "P11509", "P04798", "P08684" ]	[ "P02768" ]	[]
DB00569	Fondaparinux	Fondaparinux (Arixtra) is a synthetic anticoagulant agent consisting of five monomeric sugar units and a O-methyl group at the reducing end of the molecule. It is structurally similar to polymeric glycosaminoglycan heparin and heparan sulfate (HS) when they are cleaved into monomeric units. The monomeric sequence in heparin and HS is thought to form the high affinity binding site for the natural anti-coagulant factor, antithrombin III (ATIII). Once bound to heparin or HS, the anticoagulant activity of ATIII is potentiated by 1000-fold. Fondaparinux potentiates the neutralizing action of ATIII on activated Factor X 300-fold. Fondaparinux may be used: to prevent venous thromboembolism in patients who have undergone orthopedic surgery of the lower limbs (e.g. hip fracture, hip replacement and knee surgery); to prevent VTE in patients undergoing abdominal surgery who are are at high risk of thromboembolic complications; in the treatment of deep vein thrombosis (DVT) and pumonary embolism (PE); in the management of unstable angina (UA) and non-ST segment elevation myocardial infarction (NSTEMI); and in the management of ST segment elevation myocardial infarction (STEMI).	solid	Approved for: (1) prophylaxis of VTE for up to one month post surgery in patients undergoing orthopedic surgery of the lower limbs such as hip fracture, hip replacement and knee surgery; (2) prophylaxis of VTE patients undergoing abdominal surgery who are at high risk of thromboembolic complications (e.g. patients undergoing abdominal cancer surgery); (3) treatment of acute DVT and PE; (4) management of UA and NSTEMI for the prevention of death and subsequent myocardial infarction (MI); and (5) management of STEMI for the prevention of death and myocardial reinfarction in patients who are managed with thrombolytics or who are initially to receive no form of reperfusion therapy. Fondaparinux should not be used as the sole anticoagulant during percutaneous coronary intervention (PCI) due to an increased risk of guiding catheter thrombosis.	Fondaparinux binds specifically to the natural anticoagulant factor, ATIII. Binding to ATIII potentiates the neutralizing action of ATIII on Factor Xa 300-times. Neutralization of Factor Xa decreases the conversion of prothrombin to thrombin, which subsequently decreases the conversion of fibrinogen to fibrin (loose meshwork). The decrease in thrombin also decreases the activation of Factor XIII, which decreases the conversion of fibrin in its loose meshwork form to its stabilized meshwork form. Disruption of the coagulation cascade effectively decreases the formation of blood clots. Fondaparinux does not inactivate thrombin (activated Factor II). According to the manufacturer, fondaparinux has no known effect on platelet function. In studies comparing fondaparinux to enoxaparin, decreases in platelet levels were observed in similar numbers of patients from both groups (2-5%) [A871,A872]. At the recommended dose, Fondaparinux does not affect fibrinolytic activity or bleeding time. There is no antidote for fondaparinux. Monitoring of the anticoagulant activity of fondaparinux is not generally required. The anti-factor Xa assay may be used to monitor therapy in special populations such as those with renal impairment or who are pregnant. Complete blood count (CBC) and kidney function should be monitored during treatment.	The antithrombotic activity of fondaparinux is the result of ATIII-mediated selective inhibition of Factor Xa. By selectively binding to ATIII, Fondaparinux potentiates (about 300 times) the neutralization of Factor Xa by ATIII. Neutralization of Factor Xa interrupts the blood coagulation cascade and thus inhibits thrombin formation and thrombus development. It is thought that fondaparinux is unlikely to induce thrombocytopenia via a heparin-induced thrombocytopenia (HIT)-like mechanism given its chemical structure [A17488]. As a result, fondaparinux has been used as an alternative anticoagulant in heparin-induced thrombocytopenia (HIT) patients [A33876,A33877,A33878]. However, it is important to note that rare cases of HIT have been reported in patients treated with fondaparinux [A33879,A33880].	100% bioavailability when administered subcutaneously	Not metabolized	As with other anticoagulants, the main concern is increased bleed risk. The risk of hemorrhage may increase with decreased renal function, body mass less than 50 kg, and moderate to severe hepatic function.	17-21 hours	94% <i>in vitro</i> protein binding specifically to ATIII	In individuals with normal kidney function, fondaparinux is eliminated in urine mainly as unchanged drug.	* 7 - 11 L (healthy adults), distributed primarily in blood	null	null	null	null	null	[ "approved", "investigational" ]	[ "B01AX", "B01A", "B01", "B" ]	[ "Humans and other mammals" ]	[ { "cost": "17.38", "description": "Arixtra (0.5 Ml Syringe) 2.5 mg/syr Syringe", "unit": "syringe" }, { "cost": "63.15", "description": "Arixtra 2.5 mg/0.5ml Solution 0.5ml Syringe", "unit": "syringe" }, { "cost": "148.62", "description": "Arixtra 7.5 mg/0.6ml Solution 0.6ml Syringe", "unit": "syringe" } ]	[]	Natural heparin pentasaccharide \| 3.4.21.6 \| Stuart factor \| Stuart-Prower factor \| AT3 \| ATIII \| Serpin C1	[ "Arixtra", "Arixtra", "Arixtra", "Arixtra", "Arixtra", "Arixtra", "Arixtra", "Arixtra", "Arixtra", "Arixtra", "Arixtra", "Arixtra", "Arixtra", "Arixtra", "Arixtra", "Arixtra", "Arixtra", "Arixtra", "Arixtra", "Arixtra", "Arixtra", "Arixtra", "Arixtra", "Arixtra", "Arixtra", "Arixtra", "Arixtra", "Arixtra", "Arixtra", "Arixtra", "Arixtra", "Arixtra", "Arixtra", "Arixtra", "Arixtra", "Arixtra", "Arixtra", "Arixtra", "Arixtra", "Arixtra", "Arixtra", "Arixtra", "Arixtra", "Arixtra", "Arixtra", "Arixtra", "Arixtra", "Arixtra", "Arixtra", "Fondaparinux Sodium", "Fondaparinux Sodium", "Fondaparinux Sodium", "Fondaparinux Sodium", "Fondaparinux Sodium", "Fondaparinux Sodium", "Fondaparinux Sodium", "Fondaparinux Sodium", "Fondaparinux Sodium", "Fondaparinux Sodium", "Fondaparinux Sodium", "Fondaparinux Sodium", "Fondaparinux Sodium", "Fondaparinux Sodium", "Fondaparinux Sodium", "Fondaparinux Sodium", "Fondaparinux Sodium", "Fondaparinux Sodium", "Fondaparinux Sodium", "Fondaparinux Sodium", "Fondaparinux Sodium", "Fondaparinux Sodium", "Fondaparinux Sodium", "Fondaparinux Sodium", "Fondaparinux Sodium", "Fondaparinux Sodium", "Fondaparinux Sodium", "Fondaparinux Sodium", "Fondaparinux Sodium", "Fondaparinux Sodium", "Fondaparinux Sodium", "Fondaparinux Sodium", "Fondaparinux Sodium", "Fondaparinux Sodium", "Fondaparinux Sodium", "Fondaparinux Sodium", "Fondaparinux Sodium Injection", "Fondaparinux Sodium Injection", "Fondaparinux Sodium Injection", "Fondaparinux Sodium Injection" ]	[]	[]	[ "P00742", "P01008" ]	[]	[]	[]

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