donb-hf/secondary-screen-dose-response-curve-parameters

broad_id string	depmap_id string	ccle_name string	screen_id string	upper_limit int64	lower_limit float64	slope float64	r2 float64	auc float64	ec50 float64	ic50 float64	name string	moa string	target string	disease.area string	indication string	smiles string	phase string	passed_str_profiling bool	row_name string
BRD-A98990573-003-01-3	ACH-000367	NCIH226_LUNG	HTS002	1	2.478964	0.057529	-0.037068	1.433468	380,001.249781	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000367
BRD-A98990573-003-01-3	ACH-001190	SKMEL2_SKIN	HTS002	1	1.246811	-0.015808	-0.229736	1.150525	149,107,225,833.317	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-001190
BRD-A98990573-003-01-3	ACH-000713	CAOV3_OVARY	HTS002	1	1.346589	0.135358	0.001704	1.168214	0.122368	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000713
BRD-A98990573-003-01-3	ACH-000672	IALM_LUNG	HTS002	1	3.397769	-0.115197	0.097976	1.771578	0.000103	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000672
BRD-A98990573-003-01-3	ACH-000875	NCIH2347_LUNG	HTS002	1	2.050145	0.171866	0.013351	1.467693	0.301243	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000875
BRD-A98990573-003-01-3	ACH-000423	SKMEL3_SKIN	HTS002	1	1.550757	0.143829	0.003124	1.296959	0.02509	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000423
BRD-A98990573-003-01-3	ACH-000553	SQ1_LUNG	HTS002	1	1.429767	0.050656	-0.045753	1.211948	0.134356	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000553
BRD-A98990573-003-01-3	ACH-000834	UMUC1_URINARY_TRACT	HTS002	1	2.420943	-0.386907	0.025175	1.570848	0.02106	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000834
BRD-A98990573-003-01-3	ACH-000252	LS1034_LARGE_INTESTINE	HTS002	1	1.764826	0.318103	0.075741	1.460723	0.016555	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000252
BRD-A98990573-003-01-3	ACH-000123	COV434_OVARY	HTS002	1	1.871036	0.971387	0.042252	1.23525	0.790329	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000123
BRD-A98990573-003-01-3	ACH-000329	CCFSTTG1_CENTRAL_NERVOUS_SYSTEM	HTS002	1	2.043009	-0.033437	-0.174835	1.543977	1.035926	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000329
BRD-A98990573-003-01-3	ACH-000717	COLO680N_OESOPHAGUS	HTS002	1	1.78235	-0.034124	-0.001352	1.389012	0.056457	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000717
BRD-A98990573-003-01-3	ACH-000669	SW900_LUNG	HTS002	1	1.832861	-0.00685	-0.103785	1.426702	105.043676	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000669
BRD-A98990573-003-01-3	ACH-000764	SH10TC_STOMACH	HTS002	1	1.051229	0.112602	-0.402757	1.030866	0.001776	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000764
BRD-A98990573-003-01-3	ACH-000288	BT549_BREAST	HTS002	1	1.701641	0.191987	0.074533	1.347764	0.086103	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000288
BRD-A98990573-003-01-3	ACH-000228	BICR31_UPPER_AERODIGESTIVE_TRACT	HTS002	1	2.25861	0.069242	0.033481	1.551604	2.911644	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000228
BRD-A98990573-003-01-3	ACH-000977	LNCAPCLONEFGC_PROSTATE	HTS002	1	0.971757	0.693095	-0.229357	0.983601	0.033669	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000977
BRD-A98990573-003-01-3	ACH-000397	TEN_ENDOMETRIUM	HTS002	1	2.376421	-0.009003	-0.041521	1.814746	68,925,885,048,248,780	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000397
BRD-A98990573-003-01-3	ACH-000565	RCM1_LARGE_INTESTINE	HTS002	1	1.558587	-0.55099	0.033954	1.278205	0.076446	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000565
BRD-A98990573-003-01-3	ACH-000927	BT474_BREAST	HTS002	1	1.343573	-0.196606	-0.171738	1.231561	4.08948	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000927
BRD-K47832606-001-30-1	ACH-000879	MFE296_ENDOMETRIUM	HTS002	1	0.123092	7.885006	0.523307	0.726373	0.48411	0.501776	floxuridine	DNA synthesis inhibitor	TYMS	oncology	colorectal cancer	OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O	Launched	true	ACH-000879
BRD-K47832606-001-30-1	ACH-000320	PSN1_PANCREAS	HTS002	1	0.10514	4.771221	0.972544	0.336463	0.007499	0.007879	floxuridine	DNA synthesis inhibitor	TYMS	oncology	colorectal cancer	OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O	Launched	true	ACH-000320
BRD-K47832606-001-30-1	ACH-001145	OC316_OVARY	HTS002	1	0.099077	3.864619	0.803485	0.485618	0.039244	0.041552	floxuridine	DNA synthesis inhibitor	TYMS	oncology	colorectal cancer	OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O	Launched	true	ACH-001145
BRD-K47832606-001-30-1	ACH-000873	KYSE270_OESOPHAGUS	HTS002	1	0.060055	3.816708	0.775195	0.548483	0.094523	0.097745	floxuridine	DNA synthesis inhibitor	TYMS	oncology	colorectal cancer	OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O	Launched	true	ACH-000873
BRD-K47832606-001-30-1	ACH-000855	KYSE150_OESOPHAGUS	HTS002	1	0.390028	5.593754	0.711406	0.631609	0.028491	0.037349	floxuridine	DNA synthesis inhibitor	TYMS	oncology	colorectal cancer	OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O	Launched	true	ACH-000855
BRD-K47832606-001-30-1	ACH-000913	ESS1_ENDOMETRIUM	HTS002	1	0.27864	2.113099	0.413024	0.647397	0.087092	0.128069	floxuridine	DNA synthesis inhibitor	TYMS	oncology	colorectal cancer	OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O	Launched	true	ACH-000913
BRD-K47832606-001-30-1	ACH-000558	A172_CENTRAL_NERVOUS_SYSTEM	HTS002	1	0.219398	1.167315	0.603356	0.580288	0.054058	0.088671	floxuridine	DNA synthesis inhibitor	TYMS	oncology	colorectal cancer	OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O	Launched	true	ACH-000558
BRD-K47832606-001-30-1	ACH-000593	BC3C_URINARY_TRACT	HTS002	1	0.285356	3.283477	0.629942	0.645974	0.0817	0.105699	floxuridine	DNA synthesis inhibitor	TYMS	oncology	colorectal cancer	OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O	Launched	true	ACH-000593
BRD-K47832606-001-30-1	ACH-000488	TE11_OESOPHAGUS	HTS002	1	0.236216	3.808991	0.794521	0.598061	0.060558	0.071628	floxuridine	DNA synthesis inhibitor	TYMS	oncology	colorectal cancer	OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O	Launched	true	ACH-000488
BRD-K47832606-001-30-1	ACH-000832	CAL27_UPPER_AERODIGESTIVE_TRACT	HTS002	1	0.278338	2.946289	0.812135	0.564635	0.028676	0.037794	floxuridine	DNA synthesis inhibitor	TYMS	oncology	colorectal cancer	OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O	Launched	true	ACH-000832
BRD-K47832606-001-30-1	ACH-000781	NCIH2023_LUNG	HTS002	1	0.379814	9.909888	0.441305	0.690942	0.0794	0.091684	floxuridine	DNA synthesis inhibitor	TYMS	oncology	colorectal cancer	OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O	Launched	true	ACH-000781
BRD-K47832606-001-30-1	ACH-000833	RH30_SOFT_TISSUE	HTS002	1	0.322819	1.710281	0.592769	0.543245	0.01433	0.026284	floxuridine	DNA synthesis inhibitor	TYMS	oncology	colorectal cancer	OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O	Launched	true	ACH-000833
BRD-K47832606-001-30-1	ACH-000137	8MGBA_CENTRAL_NERVOUS_SYSTEM	HTS002	1	0.188678	2.328343	0.757438	0.581448	0.066961	0.082072	floxuridine	DNA synthesis inhibitor	TYMS	oncology	colorectal cancer	OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O	Launched	true	ACH-000137
BRD-K47832606-001-30-1	ACH-000632	HS944T_SKIN	HTS002	1	0.185653	3.906275	0.661074	0.560786	0.05333	0.060058	floxuridine	DNA synthesis inhibitor	TYMS	oncology	colorectal cancer	OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O	Launched	true	ACH-000632
BRD-K47832606-001-30-1	ACH-000319	MPP89_PLEURA	HTS002	1	2.515378	-0.014656	-0.013553	1.771409	0.925875	null	floxuridine	DNA synthesis inhibitor	TYMS	oncology	colorectal cancer	OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O	Launched	true	ACH-000319
BRD-K47832606-001-30-1	ACH-000630	YD8_UPPER_AERODIGESTIVE_TRACT	HTS002	1	0.425762	2.865641	0.030134	0.85194	0.819372	1.594198	floxuridine	DNA synthesis inhibitor	TYMS	oncology	colorectal cancer	OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O	Launched	true	ACH-000630
BRD-K47832606-001-30-1	ACH-000266	SNU213_PANCREAS	HTS002	1	1.522356	-6.680382	0.191283	1.111944	0.004884	null	floxuridine	DNA synthesis inhibitor	TYMS	oncology	colorectal cancer	OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O	Launched	true	ACH-000266
BRD-K47832606-001-30-1	ACH-000047	GCIY_STOMACH	HTS002	1	0.223612	2.620157	0.775777	0.573586	0.048452	0.060754	floxuridine	DNA synthesis inhibitor	TYMS	oncology	colorectal cancer	OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O	Launched	true	ACH-000047
BRD-K47832606-001-30-1	ACH-000273	SF539_CENTRAL_NERVOUS_SYSTEM	HTS002	1	0.131052	4.46567	0.760405	0.492328	0.034496	0.036926	floxuridine	DNA synthesis inhibitor	TYMS	oncology	colorectal cancer	OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O	Launched	true	ACH-000273
BRD-K47832606-001-30-1	ACH-000682	SNU1066_UPPER_AERODIGESTIVE_TRACT	HTS002	1	0.22864	2.817694	0.774301	0.572712	0.046286	0.057498	floxuridine	DNA synthesis inhibitor	TYMS	oncology	colorectal cancer	OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O	Launched	true	ACH-000682
BRD-K47832606-001-30-1	ACH-000359	MG63_BONE	HTS002	1	0.293324	2.729806	0.654008	0.750275	0.324131	0.447995	floxuridine	DNA synthesis inhibitor	TYMS	oncology	colorectal cancer	OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O	Launched	true	ACH-000359
BRD-K47832606-001-30-1	ACH-000846	FADU_UPPER_AERODIGESTIVE_TRACT	HTS002	1	0.101684	0.891676	0.883318	0.492464	0.040847	0.052711	floxuridine	DNA synthesis inhibitor	TYMS	oncology	colorectal cancer	OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O	Launched	true	ACH-000846
BRD-K47832606-001-30-1	ACH-000804	NB1_AUTONOMIC_GANGLIA	HTS002	1	0.073301	1.959961	0.972829	0.421177	0.023306	0.025269	floxuridine	DNA synthesis inhibitor	TYMS	oncology	colorectal cancer	OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O	Launched	true	ACH-000804
BRD-K47832606-001-30-1	ACH-000609	SF126_CENTRAL_NERVOUS_SYSTEM	HTS002	1	-0.038818	0.519385	0.784649	0.418278	0.030612	0.026508	floxuridine	DNA synthesis inhibitor	TYMS	oncology	colorectal cancer	OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O	Launched	true	ACH-000609
BRD-K47832606-001-30-1	ACH-000974	SNGM_ENDOMETRIUM	HTS002	1	0.226438	3.244132	0.466407	0.649378	0.122966	0.148088	floxuridine	DNA synthesis inhibitor	TYMS	oncology	colorectal cancer	OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O	Launched	true	ACH-000974
BRD-K47832606-001-30-1	ACH-000987	MEWO_SKIN	HTS002	1	0.149936	1.387641	0.812502	0.592523	0.095506	0.123481	floxuridine	DNA synthesis inhibitor	TYMS	oncology	colorectal cancer	OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O	Launched	true	ACH-000987
BRD-K47832606-001-30-1	ACH-000787	LXF289_LUNG	HTS002	1	0.229243	5.140688	0.849299	0.521692	0.024247	0.02732	floxuridine	DNA synthesis inhibitor	TYMS	oncology	colorectal cancer	OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O	Launched	true	ACH-000787
BRD-K47832606-001-30-1	ACH-000561	TT_OESOPHAGUS	HTS002	1	0.194131	3.821604	0.732601	0.536222	0.037549	0.042702	floxuridine	DNA synthesis inhibitor	TYMS	oncology	colorectal cancer	OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O	Launched	true	ACH-000561
BRD-K47832606-001-30-1	ACH-000212	CAL120_BREAST	HTS002	1	0.169088	1.825458	0.844268	0.639196	0.147939	0.185473	floxuridine	DNA synthesis inhibitor	TYMS	oncology	colorectal cancer	OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O	Launched	true	ACH-000212
BRD-K47832606-001-30-1	ACH-000753	JMSU1_URINARY_TRACT	HTS002	1	0.071853	1.297696	0.77363	0.652125	0.265021	0.298676	floxuridine	DNA synthesis inhibitor	TYMS	oncology	colorectal cancer	OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O	Launched	true	ACH-000753
BRD-K47832606-001-30-1	ACH-000305	ECGI10_OESOPHAGUS	HTS002	1	0.33356	2.198212	0.786261	0.693634	0.115508	0.190516	floxuridine	DNA synthesis inhibitor	TYMS	oncology	colorectal cancer	OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O	Launched	true	ACH-000305
BRD-K47832606-001-30-1	ACH-000138	CFPAC1_PANCREAS	HTS002	1	0.100176	0.899843	0.676359	0.409957	0.016351	0.020963	floxuridine	DNA synthesis inhibitor	TYMS	oncology	colorectal cancer	OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O	Launched	true	ACH-000138
BRD-K47832606-001-30-1	ACH-000250	KMRC20_KIDNEY	HTS002	1	0.325036	5.218719	0.656166	0.666281	0.082467	0.100847	floxuridine	DNA synthesis inhibitor	TYMS	oncology	colorectal cancer	OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O	Launched	true	ACH-000250
BRD-K47832606-001-30-1	ACH-000856	CAL51_BREAST	HTS002	1	0.242264	5.051557	0.81304	0.571427	0.041337	0.047131	floxuridine	DNA synthesis inhibitor	TYMS	oncology	colorectal cancer	OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O	Launched	true	ACH-000856
BRD-K47832606-001-30-1	ACH-000046	ACHN_KIDNEY	HTS002	1	0.032024	2.346294	0.797691	0.441029	0.036839	0.037893	floxuridine	DNA synthesis inhibitor	TYMS	oncology	colorectal cancer	OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O	Launched	true	ACH-000046
BRD-K47832606-001-30-1	ACH-000878	HCC15_LUNG	HTS002	1	0.292419	3.746697	0.852231	0.602022	0.042619	0.053889	floxuridine	DNA synthesis inhibitor	TYMS	oncology	colorectal cancer	OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O	Launched	true	ACH-000878
BRD-K47832606-001-30-1	ACH-000766	NCIH1648_LUNG	HTS002	1	0.178486	6.801478	0.839077	0.530087	0.038843	0.041448	floxuridine	DNA synthesis inhibitor	TYMS	oncology	colorectal cancer	OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O	Launched	true	ACH-000766
BRD-K47832606-001-30-1	ACH-000666	NCIH1355_LUNG	HTS002	1	0.486426	2.745142	0.401085	0.75265	0.093375	0.347363	floxuridine	DNA synthesis inhibitor	TYMS	oncology	colorectal cancer	OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O	Launched	true	ACH-000666
BRD-K47832606-001-30-1	ACH-000014	HS294T_SKIN	HTS002	1	0.190261	3.40639	0.653899	0.546061	0.04339	0.04994	floxuridine	DNA synthesis inhibitor	TYMS	oncology	colorectal cancer	OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O	Launched	true	ACH-000014
BRD-K47832606-001-30-1	ACH-000701	RMUGS_OVARY	HTS002	1	0.327732	1.554079	0.635325	0.641891	0.056868	0.112887	floxuridine	DNA synthesis inhibitor	TYMS	oncology	colorectal cancer	OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O	Launched	true	ACH-000701
BRD-K47832606-001-30-1	ACH-000884	MDAMB435S_SKIN	HTS002	1	1.468327	-2.133493	0.420368	1.246145	0.10014	null	floxuridine	DNA synthesis inhibitor	TYMS	oncology	colorectal cancer	OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O	Launched	true	ACH-000884
BRD-K47832606-001-30-1	ACH-000037	S117_SOFT_TISSUE	HTS002	1	0.24471	2.80327	0.534332	0.647703	0.1082	0.137521	floxuridine	DNA synthesis inhibitor	TYMS	oncology	colorectal cancer	OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O	Launched	true	ACH-000037
BRD-K47832606-001-30-1	ACH-000504	SNB75_CENTRAL_NERVOUS_SYSTEM	HTS002	1	0.145945	4.673798	0.540869	0.601978	0.108622	0.116947	floxuridine	DNA synthesis inhibitor	TYMS	oncology	colorectal cancer	OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O	Launched	true	ACH-000504
BRD-K47832606-001-30-1	ACH-000502	TCCPAN2_PANCREAS	HTS002	1	0.240968	4.698223	0.74694	0.646632	0.109136	0.125534	floxuridine	DNA synthesis inhibitor	TYMS	oncology	colorectal cancer	OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O	Launched	true	ACH-000502
BRD-K47832606-001-30-1	ACH-000886	NCIH2009_LUNG	HTS002	1	0.053788	6.749659	0.887671	0.30824	0.008297	0.008438	floxuridine	DNA synthesis inhibitor	TYMS	oncology	colorectal cancer	OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O	Launched	true	ACH-000886
BRD-K47832606-001-30-1	ACH-000035	NCIH1650_LUNG	HTS002	1	0.549551	8.693176	0.452271	0.773775	0.076459	null	floxuridine	DNA synthesis inhibitor	TYMS	oncology	colorectal cancer	OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O	Launched	true	ACH-000035
BRD-K47832606-001-30-1	ACH-000661	WM1799_SKIN	HTS002	1	0.172981	0.997392	0.751888	0.459293	0.016976	0.025985	floxuridine	DNA synthesis inhibitor	TYMS	oncology	colorectal cancer	OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O	Launched	true	ACH-000661
BRD-K47832606-001-30-1	ACH-000391	MHHES1_BONE	HTS002	1	0.057975	5.871609	0.689743	0.513058	0.066302	0.067708	floxuridine	DNA synthesis inhibitor	TYMS	oncology	colorectal cancer	OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O	Launched	true	ACH-000391
BRD-K47832606-001-30-1	ACH-000843	HARA_LUNG	HTS002	1	0.266728	2.027041	0.643432	0.590675	0.044402	0.064677	floxuridine	DNA synthesis inhibitor	TYMS	oncology	colorectal cancer	OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O	Launched	true	ACH-000843
BRD-K47832606-001-30-1	ACH-000711	JIMT1_BREAST	HTS002	1	0.258613	3.917281	0.331083	0.668526	0.130536	0.157205	floxuridine	DNA synthesis inhibitor	TYMS	oncology	colorectal cancer	OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O	Launched	true	ACH-000711
BRD-K47832606-001-30-1	ACH-000232	U251MG_CENTRAL_NERVOUS_SYSTEM	HTS002	1	0.111125	1.786807	0.673534	0.508229	0.046588	0.053625	floxuridine	DNA synthesis inhibitor	TYMS	oncology	colorectal cancer	OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O	Launched	true	ACH-000232
BRD-K47832606-001-30-1	ACH-000060	PANC1005_PANCREAS	HTS002	1	0.365577	5.680825	0.614259	0.653408	0.049844	0.062812	floxuridine	DNA synthesis inhibitor	TYMS	oncology	colorectal cancer	OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O	Launched	true	ACH-000060
BRD-K47832606-001-30-1	ACH-000322	HT144_SKIN	HTS002	1	0.156055	4.765827	0.456102	0.617693	0.123272	0.133339	floxuridine	DNA synthesis inhibitor	TYMS	oncology	colorectal cancer	OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O	Launched	true	ACH-000322
BRD-K47832606-001-30-1	ACH-000736	SNU601_STOMACH	HTS002	1	0.064045	2.857174	0.893413	0.338135	0.010464	0.010978	floxuridine	DNA synthesis inhibitor	TYMS	oncology	colorectal cancer	OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O	Launched	true	ACH-000736
BRD-K47832606-001-30-1	ACH-000809	KYSE410_OESOPHAGUS	HTS002	1	0.249972	1.284933	0.829526	0.563619	0.035185	0.060339	floxuridine	DNA synthesis inhibitor	TYMS	oncology	colorectal cancer	OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O	Launched	true	ACH-000809
BRD-K47832606-001-30-1	ACH-000747	NCIH1703_LUNG	HTS002	1	0.104899	1.18601	0.90381	0.676512	0.303697	0.370394	floxuridine	DNA synthesis inhibitor	TYMS	oncology	colorectal cancer	OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O	Launched	true	ACH-000747
BRD-K47832606-001-30-1	ACH-000364	U2OS_BONE	HTS002	1	1.435834	-6.467609	0.29223	1.137719	0.013101	null	floxuridine	DNA synthesis inhibitor	TYMS	oncology	colorectal cancer	OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O	Launched	true	ACH-000364
BRD-K47832606-001-30-1	ACH-000679	OE19_OESOPHAGUS	HTS002	1	0.23987	4.833581	0.682862	0.658406	0.127667	0.146147	floxuridine	DNA synthesis inhibitor	TYMS	oncology	colorectal cancer	OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O	Launched	true	ACH-000679
BRD-K47832606-001-30-1	ACH-000985	LS411N_LARGE_INTESTINE	HTS002	1	0.148856	3.086933	0.699415	0.539835	0.052662	0.05905	floxuridine	DNA synthesis inhibitor	TYMS	oncology	colorectal cancer	OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O	Launched	true	ACH-000985
BRD-K47832606-001-30-1	ACH-000441	SH4_SKIN	HTS002	1	0.502221	5.618827	0.659641	0.770076	0.113072	null	floxuridine	DNA synthesis inhibitor	TYMS	oncology	colorectal cancer	OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O	Launched	true	ACH-000441
BRD-K47832606-001-30-1	ACH-001113	LC1SQSF_LUNG	HTS002	1	0.482338	3.09893	0.214854	0.764082	0.12004	0.353063	floxuridine	DNA synthesis inhibitor	TYMS	oncology	colorectal cancer	OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O	Launched	true	ACH-001113
BRD-K47832606-001-30-1	ACH-000620	JHH1_LIVER	HTS002	1	0.655783	9.945614	0.358919	0.827884	0.078108	null	floxuridine	DNA synthesis inhibitor	TYMS	oncology	colorectal cancer	OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O	Launched	true	ACH-000620
BRD-K47832606-001-30-1	ACH-000853	NCIH661_LUNG	HTS002	1	0.52168	2.862689	0.48102	0.768694	0.091619	null	floxuridine	DNA synthesis inhibitor	TYMS	oncology	colorectal cancer	OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O	Launched	true	ACH-000853
BRD-K47832606-001-30-1	ACH-000102	GMS10_CENTRAL_NERVOUS_SYSTEM	HTS002	1	0.250206	1.810383	0.68131	0.579092	0.04306	0.063176	floxuridine	DNA synthesis inhibitor	TYMS	oncology	colorectal cancer	OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O	Launched	true	ACH-000102
BRD-K47832606-001-30-1	ACH-000648	NCIH28_PLEURA	HTS002	1	0.28697	7.031266	0.539409	0.666134	0.10633	0.120048	floxuridine	DNA synthesis inhibitor	TYMS	oncology	colorectal cancer	OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O	Launched	true	ACH-000648
BRD-K47832606-001-30-1	null	null	HTS002	1	0.131836	1.959351	0.906137	0.401642	0.012437	0.01454	floxuridine	DNA synthesis inhibitor	TYMS	oncology	colorectal cancer	OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O	Launched	false	ACH-000925_FAILED_STR
BRD-K47832606-001-30-1	ACH-001239	WM2664_SKIN	HTS002	1	0.163677	2.237879	0.855226	0.565935	0.064959	0.077552	floxuridine	DNA synthesis inhibitor	TYMS	oncology	colorectal cancer	OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O	Launched	true	ACH-001239
BRD-K47832606-001-30-1	ACH-001321	TT_THYROID	HTS002	1	0.384921	3.278042	0.722054	0.835351	0.744516	1.165452	floxuridine	DNA synthesis inhibitor	TYMS	oncology	colorectal cancer	OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O	Launched	true	ACH-001321
BRD-K47832606-001-30-1	ACH-000279	EWS502_BONE	HTS002	1	0.062731	1.855873	0.74678	0.431616	0.027802	0.029884	floxuridine	DNA synthesis inhibitor	TYMS	oncology	colorectal cancer	OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O	Launched	true	ACH-000279
BRD-K47832606-001-30-1	ACH-000172	TM87_SOFT_TISSUE	HTS002	1	0.110156	3.392582	0.895632	0.5249	0.056216	0.060494	floxuridine	DNA synthesis inhibitor	TYMS	oncology	colorectal cancer	OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O	Launched	true	ACH-000172
BRD-K47832606-001-30-1	ACH-001128	MON_SOFT_TISSUE	HTS002	1	0.125018	9.151695	0.585093	0.569529	0.08445	0.087147	floxuridine	DNA synthesis inhibitor	TYMS	oncology	colorectal cancer	OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O	Launched	true	ACH-001128
BRD-K47832606-001-30-1	ACH-000437	SW1088_CENTRAL_NERVOUS_SYSTEM	HTS002	1	0.109291	1.89719	0.694857	0.393217	0.013438	0.015304	floxuridine	DNA synthesis inhibitor	TYMS	oncology	colorectal cancer	OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O	Launched	true	ACH-000437
BRD-K47832606-001-30-1	ACH-000735	PECAPJ49_UPPER_AERODIGESTIVE_TRACT	HTS002	1	0.09273	1.218993	0.882721	0.39397	0.015064	0.017824	floxuridine	DNA synthesis inhibitor	TYMS	oncology	colorectal cancer	OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O	Launched	true	ACH-000735
BRD-K47832606-001-30-1	ACH-000643	HDQP1_BREAST	HTS002	1	0.379726	7.466043	0.719555	0.696771	0.087041	0.105343	floxuridine	DNA synthesis inhibitor	TYMS	oncology	colorectal cancer	OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O	Launched	true	ACH-000643
BRD-K47832606-001-30-1	ACH-000207	DETROIT562_UPPER_AERODIGESTIVE_TRACT	HTS002	1	0.266922	3.327026	0.572965	0.590454	0.044212	0.055612	floxuridine	DNA synthesis inhibitor	TYMS	oncology	colorectal cancer	OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O	Launched	true	ACH-000207
BRD-K47832606-001-30-1	ACH-000456	BCPAP_THYROID	HTS002	1	0.054028	0.735584	0.795512	0.506728	0.062682	0.073225	floxuridine	DNA synthesis inhibitor	TYMS	oncology	colorectal cancer	OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O	Launched	true	ACH-000456
BRD-K47832606-001-30-1	ACH-000260	SKNAS_AUTONOMIC_GANGLIA	HTS002	1	0.219911	5.482424	0.412103	0.558627	0.041256	0.045855	floxuridine	DNA synthesis inhibitor	TYMS	oncology	colorectal cancer	OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O	Launched	true	ACH-000260
BRD-K47832606-001-30-1	ACH-000019	MCF7_BREAST	HTS002	1	0.331773	1.034922	0.695635	0.706686	0.142477	0.408183	floxuridine	DNA synthesis inhibitor	TYMS	oncology	colorectal cancer	OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O	Launched	true	ACH-000019
BRD-K47832606-001-30-1	ACH-000582	COLO741_SKIN	HTS002	1	0.26895	1.045834	0.580407	0.71155	0.220731	0.461781	floxuridine	DNA synthesis inhibitor	TYMS	oncology	colorectal cancer	OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O	Launched	true	ACH-000582
BRD-K47832606-001-30-1	ACH-000990	HEC108_ENDOMETRIUM	HTS002	1	0.346441	3.549785	0.620228	0.650627	0.055859	0.077898	floxuridine	DNA synthesis inhibitor	TYMS	oncology	colorectal cancer	OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O	Launched	true	ACH-000990

BRD-A98990573-003-01-3

ACH-000367

NCIH226_LUNG

HTS002

1

2.478964

0.057529

-0.037068

1.433468

380,001.249781

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000367

BRD-A98990573-003-01-3

ACH-001190

SKMEL2_SKIN

HTS002

1

1.246811

-0.015808

-0.229736

1.150525

149,107,225,833.317

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-001190

BRD-A98990573-003-01-3

ACH-000713

CAOV3_OVARY

HTS002

1

1.346589

0.135358

0.001704

1.168214

0.122368

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000713

BRD-A98990573-003-01-3

ACH-000672

IALM_LUNG

HTS002

1

3.397769

-0.115197

0.097976

1.771578

0.000103

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000672

BRD-A98990573-003-01-3

ACH-000875

NCIH2347_LUNG

HTS002

1

2.050145

0.171866

0.013351

1.467693

0.301243

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000875

BRD-A98990573-003-01-3

ACH-000423

SKMEL3_SKIN

HTS002

1

1.550757

0.143829

0.003124

1.296959

0.02509

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000423

BRD-A98990573-003-01-3

ACH-000553

SQ1_LUNG

HTS002

1

1.429767

0.050656

-0.045753

1.211948

0.134356

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000553

BRD-A98990573-003-01-3

ACH-000834

UMUC1_URINARY_TRACT

HTS002

1

2.420943

-0.386907

0.025175

1.570848

0.02106

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000834

BRD-A98990573-003-01-3

ACH-000252

LS1034_LARGE_INTESTINE

HTS002

1

1.764826

0.318103

0.075741

1.460723

0.016555

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000252

BRD-A98990573-003-01-3

ACH-000123

COV434_OVARY

HTS002

1

1.871036

0.971387

0.042252

1.23525

0.790329

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000123

BRD-A98990573-003-01-3

ACH-000329

CCFSTTG1_CENTRAL_NERVOUS_SYSTEM

HTS002

1

2.043009

-0.033437

-0.174835

1.543977

1.035926

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000329

BRD-A98990573-003-01-3

ACH-000717

COLO680N_OESOPHAGUS

HTS002

1

1.78235

-0.034124

-0.001352

1.389012

0.056457

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000717

BRD-A98990573-003-01-3

ACH-000669

SW900_LUNG

HTS002

1

1.832861

-0.00685

-0.103785

1.426702

105.043676

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000669

BRD-A98990573-003-01-3

ACH-000764

SH10TC_STOMACH

HTS002

1

1.051229

0.112602

-0.402757

1.030866

0.001776

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000764

BRD-A98990573-003-01-3

ACH-000288

BT549_BREAST

HTS002

1

1.701641

0.191987

0.074533

1.347764

0.086103

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000288

BRD-A98990573-003-01-3

ACH-000228

BICR31_UPPER_AERODIGESTIVE_TRACT

HTS002

1

2.25861

0.069242

0.033481

1.551604

2.911644

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000228

BRD-A98990573-003-01-3

ACH-000977

LNCAPCLONEFGC_PROSTATE

HTS002

1

0.971757

0.693095

-0.229357

0.983601

0.033669

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000977

BRD-A98990573-003-01-3

ACH-000397

TEN_ENDOMETRIUM

HTS002

1

2.376421

-0.009003

-0.041521

1.814746

68,925,885,048,248,780

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000397

BRD-A98990573-003-01-3

ACH-000565

RCM1_LARGE_INTESTINE

HTS002

1

1.558587

-0.55099

0.033954

1.278205

0.076446

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000565

BRD-A98990573-003-01-3

ACH-000927

BT474_BREAST

HTS002

1

1.343573

-0.196606

-0.171738

1.231561

4.08948

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000927

BRD-K47832606-001-30-1

ACH-000879

MFE296_ENDOMETRIUM

HTS002

1

0.123092

7.885006

0.523307

0.726373

0.48411

0.501776

floxuridine

DNA synthesis inhibitor

TYMS

oncology

colorectal cancer

OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O

Launched

true

ACH-000879

BRD-K47832606-001-30-1

ACH-000320

PSN1_PANCREAS

HTS002

1

0.10514

4.771221

0.972544

0.336463

0.007499

0.007879

floxuridine

DNA synthesis inhibitor

TYMS

oncology

colorectal cancer

OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O

Launched

true

ACH-000320

BRD-K47832606-001-30-1

ACH-001145

OC316_OVARY

HTS002

1

0.099077

3.864619

0.803485

0.485618

0.039244

0.041552

floxuridine

DNA synthesis inhibitor

TYMS

oncology

colorectal cancer

OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O

Launched

true

ACH-001145

BRD-K47832606-001-30-1

ACH-000873

KYSE270_OESOPHAGUS

HTS002

1

0.060055

3.816708

0.775195

0.548483

0.094523

0.097745

floxuridine

DNA synthesis inhibitor

TYMS

oncology

colorectal cancer

OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O

Launched

true

ACH-000873

BRD-K47832606-001-30-1

ACH-000855

KYSE150_OESOPHAGUS

HTS002

1

0.390028

5.593754

0.711406

0.631609

0.028491

0.037349

floxuridine

DNA synthesis inhibitor

TYMS

oncology

colorectal cancer

OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O

Launched

true

ACH-000855

BRD-K47832606-001-30-1

ACH-000913

ESS1_ENDOMETRIUM

HTS002

1

0.27864

2.113099

0.413024

0.647397

0.087092

0.128069

floxuridine

DNA synthesis inhibitor

TYMS

oncology

colorectal cancer

OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O

Launched

true

ACH-000913

BRD-K47832606-001-30-1

ACH-000558

A172_CENTRAL_NERVOUS_SYSTEM

HTS002

1

0.219398

1.167315

0.603356

0.580288

0.054058

0.088671

floxuridine

DNA synthesis inhibitor

TYMS

oncology

colorectal cancer

OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O

Launched

true

ACH-000558

BRD-K47832606-001-30-1

ACH-000593

BC3C_URINARY_TRACT

HTS002

1

0.285356

3.283477

0.629942

0.645974

0.0817

0.105699

floxuridine

DNA synthesis inhibitor

TYMS

oncology

colorectal cancer

OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O

Launched

true

ACH-000593

BRD-K47832606-001-30-1

ACH-000488

TE11_OESOPHAGUS

HTS002

1

0.236216

3.808991

0.794521

0.598061

0.060558

0.071628

floxuridine

DNA synthesis inhibitor

TYMS

oncology

colorectal cancer

OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O

Launched

true

ACH-000488

BRD-K47832606-001-30-1

ACH-000832

CAL27_UPPER_AERODIGESTIVE_TRACT

HTS002

1

0.278338

2.946289

0.812135

0.564635

0.028676

0.037794

floxuridine

DNA synthesis inhibitor

TYMS

oncology

colorectal cancer

OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O

Launched

true

ACH-000832

BRD-K47832606-001-30-1

ACH-000781

NCIH2023_LUNG

HTS002

1

0.379814

9.909888

0.441305

0.690942

0.0794

0.091684

floxuridine

DNA synthesis inhibitor

TYMS

oncology

colorectal cancer

OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O

Launched

true

ACH-000781

BRD-K47832606-001-30-1

ACH-000833

RH30_SOFT_TISSUE

HTS002

1

0.322819

1.710281

0.592769

0.543245

0.01433

0.026284

floxuridine

DNA synthesis inhibitor

TYMS

oncology

colorectal cancer

OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O

Launched

true

ACH-000833

BRD-K47832606-001-30-1

ACH-000137

8MGBA_CENTRAL_NERVOUS_SYSTEM

HTS002

1

0.188678

2.328343

0.757438

0.581448

0.066961

0.082072

floxuridine

DNA synthesis inhibitor

TYMS

oncology

colorectal cancer

OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O

Launched

true

ACH-000137

BRD-K47832606-001-30-1

ACH-000632

HS944T_SKIN

HTS002

1

0.185653

3.906275

0.661074

0.560786

0.05333

0.060058

floxuridine

DNA synthesis inhibitor

TYMS

oncology

colorectal cancer

OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O

Launched

true

ACH-000632

BRD-K47832606-001-30-1

ACH-000319

MPP89_PLEURA

HTS002

1

2.515378

-0.014656

-0.013553

1.771409

0.925875

null

floxuridine

DNA synthesis inhibitor

TYMS

oncology

colorectal cancer

OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O

Launched

true

ACH-000319

BRD-K47832606-001-30-1

ACH-000630

YD8_UPPER_AERODIGESTIVE_TRACT

HTS002

1

0.425762

2.865641

0.030134

0.85194

0.819372

1.594198

floxuridine

DNA synthesis inhibitor

TYMS

oncology

colorectal cancer

OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O

Launched

true

ACH-000630

BRD-K47832606-001-30-1

ACH-000266

SNU213_PANCREAS

HTS002

1

1.522356

-6.680382

0.191283

1.111944

0.004884

null

floxuridine

DNA synthesis inhibitor

TYMS

oncology

colorectal cancer

OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O

Launched

true

ACH-000266

BRD-K47832606-001-30-1

ACH-000047

GCIY_STOMACH

HTS002

1

0.223612

2.620157

0.775777

0.573586

0.048452

0.060754

floxuridine

DNA synthesis inhibitor

TYMS

oncology

colorectal cancer

OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O

Launched

true

ACH-000047

BRD-K47832606-001-30-1

ACH-000273

SF539_CENTRAL_NERVOUS_SYSTEM

HTS002

1

0.131052

4.46567

0.760405

0.492328

0.034496

0.036926

floxuridine

DNA synthesis inhibitor

TYMS

oncology

colorectal cancer

OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O

Launched

true

ACH-000273

BRD-K47832606-001-30-1

ACH-000682

SNU1066_UPPER_AERODIGESTIVE_TRACT

HTS002

1

0.22864

2.817694

0.774301

0.572712

0.046286

0.057498

floxuridine

DNA synthesis inhibitor

TYMS

oncology

colorectal cancer

OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O

Launched

true

ACH-000682

BRD-K47832606-001-30-1

ACH-000359

MG63_BONE

HTS002

1

0.293324

2.729806

0.654008

0.750275

0.324131

0.447995

floxuridine

DNA synthesis inhibitor

TYMS

oncology

colorectal cancer

OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O

Launched

true

ACH-000359

BRD-K47832606-001-30-1

ACH-000846

FADU_UPPER_AERODIGESTIVE_TRACT

HTS002

1

0.101684

0.891676

0.883318

0.492464

0.040847

0.052711

floxuridine

DNA synthesis inhibitor

TYMS

oncology

colorectal cancer

OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O

Launched

true

ACH-000846

BRD-K47832606-001-30-1

ACH-000804

NB1_AUTONOMIC_GANGLIA

HTS002

1

0.073301

1.959961

0.972829

0.421177

0.023306

0.025269

floxuridine

DNA synthesis inhibitor

TYMS

oncology

colorectal cancer

OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O

Launched

true

ACH-000804

BRD-K47832606-001-30-1

ACH-000609

SF126_CENTRAL_NERVOUS_SYSTEM

HTS002

1

-0.038818

0.519385

0.784649

0.418278

0.030612

0.026508

floxuridine

DNA synthesis inhibitor

TYMS

oncology

colorectal cancer

OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O

Launched

true

ACH-000609

BRD-K47832606-001-30-1

ACH-000974

SNGM_ENDOMETRIUM

HTS002

1

0.226438

3.244132

0.466407

0.649378

0.122966

0.148088

floxuridine

DNA synthesis inhibitor

TYMS

oncology

colorectal cancer

OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O

Launched

true

ACH-000974

BRD-K47832606-001-30-1

ACH-000987

MEWO_SKIN

HTS002

1

0.149936

1.387641

0.812502

0.592523

0.095506

0.123481

floxuridine

DNA synthesis inhibitor

TYMS

oncology

colorectal cancer

OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O

Launched

true

ACH-000987

BRD-K47832606-001-30-1

ACH-000787

LXF289_LUNG

HTS002

1

0.229243

5.140688

0.849299

0.521692

0.024247

0.02732

floxuridine

DNA synthesis inhibitor

TYMS

oncology

colorectal cancer

OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O

Launched

true

ACH-000787

BRD-K47832606-001-30-1

ACH-000561

TT_OESOPHAGUS

HTS002

1

0.194131

3.821604

0.732601

0.536222

0.037549

0.042702

floxuridine

DNA synthesis inhibitor

TYMS

oncology

colorectal cancer

OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O

Launched

true

ACH-000561

BRD-K47832606-001-30-1

ACH-000212

CAL120_BREAST

HTS002

1

0.169088

1.825458

0.844268

0.639196

0.147939

0.185473

floxuridine

DNA synthesis inhibitor

TYMS

oncology

colorectal cancer

OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O

Launched

true

ACH-000212

BRD-K47832606-001-30-1

ACH-000753

JMSU1_URINARY_TRACT

HTS002

1

0.071853

1.297696

0.77363

0.652125

0.265021

0.298676

floxuridine

DNA synthesis inhibitor

TYMS

oncology

colorectal cancer

OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O

Launched

true

ACH-000753

BRD-K47832606-001-30-1

ACH-000305

ECGI10_OESOPHAGUS

HTS002

1

0.33356

2.198212

0.786261

0.693634

0.115508

0.190516

floxuridine

DNA synthesis inhibitor

TYMS

oncology

colorectal cancer

OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O

Launched

true

ACH-000305

BRD-K47832606-001-30-1

ACH-000138

CFPAC1_PANCREAS

HTS002

1

0.100176

0.899843

0.676359

0.409957

0.016351

0.020963

floxuridine

DNA synthesis inhibitor

TYMS

oncology

colorectal cancer

OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O

Launched

true

ACH-000138

BRD-K47832606-001-30-1

ACH-000250

KMRC20_KIDNEY

HTS002

1

0.325036

5.218719

0.656166

0.666281

0.082467

0.100847

floxuridine

DNA synthesis inhibitor

TYMS

oncology

colorectal cancer

OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O

Launched

true

ACH-000250

BRD-K47832606-001-30-1

ACH-000856

CAL51_BREAST

HTS002

1

0.242264

5.051557

0.81304

0.571427

0.041337

0.047131

floxuridine

DNA synthesis inhibitor

TYMS

oncology

colorectal cancer

OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O

Launched

true

ACH-000856

BRD-K47832606-001-30-1

ACH-000046

ACHN_KIDNEY

HTS002

1

0.032024

2.346294

0.797691

0.441029

0.036839

0.037893

floxuridine

DNA synthesis inhibitor

TYMS

oncology

colorectal cancer

OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O

Launched

true

ACH-000046

BRD-K47832606-001-30-1

ACH-000878

HCC15_LUNG

HTS002

1

0.292419

3.746697

0.852231

0.602022

0.042619

0.053889

floxuridine

DNA synthesis inhibitor

TYMS

oncology

colorectal cancer

OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O

Launched

true

ACH-000878

BRD-K47832606-001-30-1

ACH-000766

NCIH1648_LUNG

HTS002

1

0.178486

6.801478

0.839077

0.530087

0.038843

0.041448

floxuridine

DNA synthesis inhibitor

TYMS

oncology

colorectal cancer

OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O

Launched

true

ACH-000766

BRD-K47832606-001-30-1

ACH-000666

NCIH1355_LUNG

HTS002

1

0.486426

2.745142

0.401085

0.75265

0.093375

0.347363

floxuridine

DNA synthesis inhibitor

TYMS

oncology

colorectal cancer

OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O

Launched

true

ACH-000666

BRD-K47832606-001-30-1

ACH-000014

HS294T_SKIN

HTS002

1

0.190261

3.40639

0.653899

0.546061

0.04339

0.04994

floxuridine

DNA synthesis inhibitor

TYMS

oncology

colorectal cancer

OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O

Launched

true

ACH-000014

BRD-K47832606-001-30-1

ACH-000701

RMUGS_OVARY

HTS002

1

0.327732

1.554079

0.635325

0.641891

0.056868

0.112887

floxuridine

DNA synthesis inhibitor

TYMS

oncology

colorectal cancer

OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O

Launched

true

ACH-000701

BRD-K47832606-001-30-1

ACH-000884

MDAMB435S_SKIN

HTS002

1

1.468327

-2.133493

0.420368

1.246145

0.10014

null

floxuridine

DNA synthesis inhibitor

TYMS

oncology

colorectal cancer

OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O

Launched

true

ACH-000884

BRD-K47832606-001-30-1

ACH-000037

S117_SOFT_TISSUE

HTS002

1

0.24471

2.80327

0.534332

0.647703

0.1082

0.137521

floxuridine

DNA synthesis inhibitor

TYMS

oncology

colorectal cancer

OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O

Launched

true

ACH-000037

BRD-K47832606-001-30-1

ACH-000504

SNB75_CENTRAL_NERVOUS_SYSTEM

HTS002

1

0.145945

4.673798

0.540869

0.601978

0.108622

0.116947

floxuridine

DNA synthesis inhibitor

TYMS

oncology

colorectal cancer

OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O

Launched

true

ACH-000504

BRD-K47832606-001-30-1

ACH-000502

TCCPAN2_PANCREAS

HTS002

1

0.240968

4.698223

0.74694

0.646632

0.109136

0.125534

floxuridine

DNA synthesis inhibitor

TYMS

oncology

colorectal cancer

OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O

Launched

true

ACH-000502

BRD-K47832606-001-30-1

ACH-000886

NCIH2009_LUNG

HTS002

1

0.053788

6.749659

0.887671

0.30824

0.008297

0.008438

floxuridine

DNA synthesis inhibitor

TYMS

oncology

colorectal cancer

OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O

Launched

true

ACH-000886

BRD-K47832606-001-30-1

ACH-000035

NCIH1650_LUNG

HTS002

1

0.549551

8.693176

0.452271

0.773775

0.076459

null

floxuridine

DNA synthesis inhibitor

TYMS

oncology

colorectal cancer

OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O

Launched

true

ACH-000035

BRD-K47832606-001-30-1

ACH-000661

WM1799_SKIN

HTS002

1

0.172981

0.997392

0.751888

0.459293

0.016976

0.025985

floxuridine

DNA synthesis inhibitor

TYMS

oncology

colorectal cancer

OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O

Launched

true

ACH-000661

BRD-K47832606-001-30-1

ACH-000391

MHHES1_BONE

HTS002

1

0.057975

5.871609

0.689743

0.513058

0.066302

0.067708

floxuridine

DNA synthesis inhibitor

TYMS

oncology

colorectal cancer

OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O

Launched

true

ACH-000391

BRD-K47832606-001-30-1

ACH-000843

HARA_LUNG

HTS002

1

0.266728

2.027041

0.643432

0.590675

0.044402

0.064677

floxuridine

DNA synthesis inhibitor

TYMS

oncology

colorectal cancer

OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O

Launched

true

ACH-000843

BRD-K47832606-001-30-1

ACH-000711

JIMT1_BREAST

HTS002

1

0.258613

3.917281

0.331083

0.668526

0.130536

0.157205

floxuridine

DNA synthesis inhibitor

TYMS

oncology

colorectal cancer

OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O

Launched

true

ACH-000711

BRD-K47832606-001-30-1

ACH-000232

U251MG_CENTRAL_NERVOUS_SYSTEM

HTS002

1

0.111125

1.786807

0.673534

0.508229

0.046588

0.053625

floxuridine

DNA synthesis inhibitor

TYMS

oncology

colorectal cancer

OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O

Launched

true

ACH-000232

BRD-K47832606-001-30-1

ACH-000060

PANC1005_PANCREAS

HTS002

1

0.365577

5.680825

0.614259

0.653408

0.049844

0.062812

floxuridine

DNA synthesis inhibitor

TYMS

oncology

colorectal cancer

OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O

Launched

true

ACH-000060

BRD-K47832606-001-30-1

ACH-000322

HT144_SKIN

HTS002

1

0.156055

4.765827

0.456102

0.617693

0.123272

0.133339

floxuridine

DNA synthesis inhibitor

TYMS

oncology

colorectal cancer

OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O

Launched

true

ACH-000322

BRD-K47832606-001-30-1

ACH-000736

SNU601_STOMACH

HTS002

1

0.064045

2.857174

0.893413

0.338135

0.010464

0.010978

floxuridine

DNA synthesis inhibitor

TYMS

oncology

colorectal cancer

OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O

Launched

true

ACH-000736

BRD-K47832606-001-30-1

ACH-000809

KYSE410_OESOPHAGUS

HTS002

1

0.249972

1.284933

0.829526

0.563619

0.035185

0.060339

floxuridine

DNA synthesis inhibitor

TYMS

oncology

colorectal cancer

OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O

Launched

true

ACH-000809

BRD-K47832606-001-30-1

ACH-000747

NCIH1703_LUNG

HTS002

1

0.104899

1.18601

0.90381

0.676512

0.303697

0.370394

floxuridine

DNA synthesis inhibitor

TYMS

oncology

colorectal cancer

OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O

Launched

true

ACH-000747

BRD-K47832606-001-30-1

ACH-000364

U2OS_BONE

HTS002

1

1.435834

-6.467609

0.29223

1.137719

0.013101

null

floxuridine

DNA synthesis inhibitor

TYMS

oncology

colorectal cancer

OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O

Launched

true

ACH-000364

BRD-K47832606-001-30-1

ACH-000679

OE19_OESOPHAGUS

HTS002

1

0.23987

4.833581

0.682862

0.658406

0.127667

0.146147

floxuridine

DNA synthesis inhibitor

TYMS

oncology

colorectal cancer

OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O

Launched

true

ACH-000679

BRD-K47832606-001-30-1

ACH-000985

LS411N_LARGE_INTESTINE

HTS002

1

0.148856

3.086933

0.699415

0.539835

0.052662

0.05905

floxuridine

DNA synthesis inhibitor

TYMS

oncology

colorectal cancer

OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O

Launched

true

ACH-000985

BRD-K47832606-001-30-1

ACH-000441

SH4_SKIN

HTS002

1

0.502221

5.618827

0.659641

0.770076

0.113072

null

floxuridine

DNA synthesis inhibitor

TYMS

oncology

colorectal cancer

OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O

Launched

true

ACH-000441

BRD-K47832606-001-30-1

ACH-001113

LC1SQSF_LUNG

HTS002

1

0.482338

3.09893

0.214854

0.764082

0.12004

0.353063

floxuridine

DNA synthesis inhibitor

TYMS

oncology

colorectal cancer

OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O

Launched

true

ACH-001113

BRD-K47832606-001-30-1

ACH-000620

JHH1_LIVER

HTS002

1

0.655783

9.945614

0.358919

0.827884

0.078108

null

floxuridine

DNA synthesis inhibitor

TYMS

oncology

colorectal cancer

OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O

Launched

true

ACH-000620

BRD-K47832606-001-30-1

ACH-000853

NCIH661_LUNG

HTS002

1

0.52168

2.862689

0.48102

0.768694

0.091619

null

floxuridine

DNA synthesis inhibitor

TYMS

oncology

colorectal cancer

OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O

Launched

true

ACH-000853

BRD-K47832606-001-30-1

ACH-000102

GMS10_CENTRAL_NERVOUS_SYSTEM

HTS002

1

0.250206

1.810383

0.68131

0.579092

0.04306

0.063176

floxuridine

DNA synthesis inhibitor

TYMS

oncology

colorectal cancer

OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O

Launched

true

ACH-000102

BRD-K47832606-001-30-1

ACH-000648

NCIH28_PLEURA

HTS002

1

0.28697

7.031266

0.539409

0.666134

0.10633

0.120048

floxuridine

DNA synthesis inhibitor

TYMS

oncology

colorectal cancer

OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O

Launched

true

ACH-000648

BRD-K47832606-001-30-1

null

HTS002

1

0.131836

1.959351

0.906137

0.401642

0.012437

0.01454

floxuridine

DNA synthesis inhibitor

TYMS

oncology

colorectal cancer

OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O

Launched

false

ACH-000925_FAILED_STR

BRD-K47832606-001-30-1

ACH-001239

WM2664_SKIN

HTS002

1

0.163677

2.237879

0.855226

0.565935

0.064959

0.077552

floxuridine

DNA synthesis inhibitor

TYMS

oncology

colorectal cancer

OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O

Launched

true

ACH-001239

BRD-K47832606-001-30-1

ACH-001321

TT_THYROID

HTS002

1

0.384921

3.278042

0.722054

0.835351

0.744516

1.165452

floxuridine

DNA synthesis inhibitor

TYMS

oncology

colorectal cancer

OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O

Launched

true

ACH-001321

BRD-K47832606-001-30-1

ACH-000279

EWS502_BONE

HTS002

1

0.062731

1.855873

0.74678

0.431616

0.027802

0.029884

floxuridine

DNA synthesis inhibitor

TYMS

oncology

colorectal cancer

OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O

Launched

true

ACH-000279

BRD-K47832606-001-30-1

ACH-000172

TM87_SOFT_TISSUE

HTS002

1

0.110156

3.392582

0.895632

0.5249

0.056216

0.060494

floxuridine

DNA synthesis inhibitor

TYMS

oncology

colorectal cancer

OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O

Launched

true

ACH-000172

BRD-K47832606-001-30-1

ACH-001128

MON_SOFT_TISSUE

HTS002

1

0.125018

9.151695

0.585093

0.569529

0.08445

0.087147

floxuridine

DNA synthesis inhibitor

TYMS

oncology

colorectal cancer

OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O

Launched

true

ACH-001128

BRD-K47832606-001-30-1

ACH-000437

SW1088_CENTRAL_NERVOUS_SYSTEM

HTS002

1

0.109291

1.89719

0.694857

0.393217

0.013438

0.015304

floxuridine

DNA synthesis inhibitor

TYMS

oncology

colorectal cancer

OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O

Launched

true

ACH-000437

BRD-K47832606-001-30-1

ACH-000735

PECAPJ49_UPPER_AERODIGESTIVE_TRACT

HTS002

1

0.09273

1.218993

0.882721

0.39397

0.015064

0.017824

floxuridine

DNA synthesis inhibitor

TYMS

oncology

colorectal cancer

OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O

Launched

true

ACH-000735

BRD-K47832606-001-30-1

ACH-000643

HDQP1_BREAST

HTS002

1

0.379726

7.466043

0.719555

0.696771

0.087041

0.105343

floxuridine

DNA synthesis inhibitor

TYMS

oncology

colorectal cancer

OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O

Launched

true

ACH-000643

BRD-K47832606-001-30-1

ACH-000207

DETROIT562_UPPER_AERODIGESTIVE_TRACT

HTS002

1

0.266922

3.327026

0.572965

0.590454

0.044212

0.055612

floxuridine

DNA synthesis inhibitor

TYMS

oncology

colorectal cancer

OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O

Launched

true

ACH-000207

BRD-K47832606-001-30-1

ACH-000456

BCPAP_THYROID

HTS002

1

0.054028

0.735584

0.795512

0.506728

0.062682

0.073225

floxuridine

DNA synthesis inhibitor

TYMS

oncology

colorectal cancer

OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O

Launched

true

ACH-000456

BRD-K47832606-001-30-1

ACH-000260

SKNAS_AUTONOMIC_GANGLIA

HTS002

1

0.219911

5.482424

0.412103

0.558627

0.041256

0.045855

floxuridine

DNA synthesis inhibitor

TYMS

oncology

colorectal cancer

OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O

Launched

true

ACH-000260

BRD-K47832606-001-30-1

ACH-000019

MCF7_BREAST

HTS002

1

0.331773

1.034922

0.695635

0.706686

0.142477

0.408183

floxuridine

DNA synthesis inhibitor

TYMS

oncology

colorectal cancer

OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O

Launched

true

ACH-000019

BRD-K47832606-001-30-1

ACH-000582

COLO741_SKIN

HTS002

1

0.26895

1.045834

0.580407

0.71155

0.220731

0.461781

floxuridine

DNA synthesis inhibitor

TYMS

oncology

colorectal cancer

OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O

Launched

true

ACH-000582

BRD-K47832606-001-30-1

ACH-000990

HEC108_ENDOMETRIUM

HTS002

1

0.346441

3.549785

0.620228

0.650627

0.055859

0.077898

floxuridine

DNA synthesis inhibitor

TYMS

oncology

colorectal cancer

OC[C@H]1OC(C[C@H]1O)n1cc(F)c(=O)[nH]c1=O, OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O

Launched

true

ACH-000990