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Control of pancreatic islet function and glucose homeostasis by a novel microexon program misregulated in type 2 diabetes
|
molecular biology
|
Mmp14-controlled extracellular matrix homeostasis is required for circadian rhythm
|
cell biology
|
Xport-A functions as a chaperone by stabilizing the first 5 transmembrane domains of Rhodopsin-1
|
cell biology
|
Unifying genetic association tests via regression: Prospective and retrospective, parametric and non-parametric, and genotype- and allele-based tests
|
genomics
|
Appia: a web interface for chromatography
|
biochemistry
|
Cotranslational folding and assembly of the dimeric E. coli inner membrane protein EmrE
|
biochemistry
|
Highly multiplexed targeted plasma proteomics quantifies several hundred blood proteins in serum from colorectal carcinoma patients
|
biochemistry
|
Clinically-relevant treatment of PDX models reveals patterns of neuroblastoma chemoresistance
|
cancer biology
|
Oncogenic mutations in the DNA-binding domain of FOXO1 disrupt folding: quantitative insights from experiments and molecular simulations
|
cancer biology
|
Microgravity enhances the phenotype of Arabidopsis zigzag-1 and reduces the Wortmannin-induced vacuole fusion in root cells
|
plant biology
|
Computational design and construction of an Escherichia coli strain engineered to produce a non-standard amino acid
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systems biology
|
Reduced cutaneous CD200:CD200R1 signalling in psoriasis enhances neutrophil recruitment to skin
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immunology
|
IMC10 and LMF1 mediate membrane contact between the mitochondrion and the inner membrane complex in Toxoplasma gondii
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microbiology
|
Artificial selection methods from evolutionary computing show promise for directed evolution of microbes
|
evolutionary biology
|
Approximations to the expectations and variances of ratios of tree properties under the coalescent
|
genetics
|
DeepAcr: Predicting Anti-CRISPR with Deep Learning
|
bioinformatics
|
TP53 somatic mutations in Asian breast cancer are associated with subtype-specific effects
|
cancer biology
|
Dual pathway architecture underlying vocal learning in songbirds
|
neuroscience
|
A retrospective and stepwise learning strategy revealed by neuronal activity in the basal forebrain
|
neuroscience
|
FCHO controls AP2's critical endocytic roles through a PtdIns4,5P2 membrane-dependent switch
|
cell biology
|
Reduced mitochondria provide an essential function for the cytosolic methionine cycle
|
cell biology
|
A Locally Activatable Sensor for Robust Quantification of Organellar Glutathione
|
cell biology
|
Death-seq identifies regulators of cell death and senolytic therapies
|
cell biology
|
Pathogenic variants of sphingomyelin synthase SMS2 disrupt lipid landscapes in the secretory pathway
|
cell biology
|
A dual mechanism of APC/C inhibition by MAP kinases
|
cell biology
|
Surface curvature and basal hydraulic stress induce spatial bias in cell extrusion
|
cell biology
|
Dietary αKG inhibits SARS CoV-2 infection and rescues inflamed lungs to restore normal O2 saturation in animals
|
pathology
|
RNA methylation influences TDP43 binding and disease pathogenesis in models of amyotrophic lateral sclerosis and frontotemporal dementia
|
neuroscience
|
Conformational Flexibility in Neutralization of SARS-CoV-2 by Naturally Elicited Anti-SARS-CoV-2 Antibodies
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immunology
|
SARS-CoV-2 spike S375F mutation characterizes the Omicron BA.1 variant
|
microbiology
|
Compound interaction screen on a photoactivatable cellulose membrane (CISCM) identifies drug targets
|
biochemistry
|
Kinetic and Redox Characterization of KRAS G12C Inhibition
|
biochemistry
|
Molecular basis of neurodevelopmental disorder-causing mutation in nonsense-mediated mRNA decay factor UPF3B
|
biochemistry
|
SEACells: Inference of transcriptional and epigenomic cellular states from single-cell genomics data
|
bioinformatics
|
A co-operative knock-on mechanism underpins Ca2+-selective cation permeation in TRPV channels
|
biophysics
|
Farnesyltransferase inhibition overcomes the adaptive resistance to osimertinib in EGFR-mutant NSCLC
|
cancer biology
|
NSMCE2, a Novel Super-Enhancer Regulated Gene, is Linked to Poor Prognosis and Therapy Resistance in Breast Cancer
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cancer biology
|
Modulation of Receptor-like Trans-Membrane Kinase 1 nuclear localisation by DA1 peptidases in Arabidopsis.
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plant biology
|
Harnessing cellular perception apparatus for smart metabolic reprogramming
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synthetic biology
|
VMHdm/cSF-1 Neuronal Circuits Regulate Skeletal Muscle PGC1-α via the Sympathoadrenal Drive
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neuroscience
|
M2e-specific monoclonal antibody cocktails against influenza A virus are superior to individual monoclonal antibody treatments, universally effective, and viral escape mutant resistant
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immunology
|
Transcriptional reprogramming from innate immune functions to a pro-thrombotic signature upon SARS-CoV-2 sensing by monocytes in COVID-19
|
immunology
|
CD169+ macrophages orchestrate plasmacytoid dendritic cell arrest and retention for optimal priming in the bone marrow of malaria-infected mice
|
immunology
|
Dynamics of drug response in single mycobacterial cells by microfluidic dose-response assay
|
microbiology
|
Melanization is an important antifungal defense mechanism in Galleria mellonella hosts
|
microbiology
|
Single-cell profiling of lncRNAs in human germ cells and molecular analysis reveals transcriptional regulation of LNC1845 on LHX8
|
developmental biology
|
Asexual male production by ZW recombination in Artemia parthenogenetica
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evolutionary biology
|
Allele mining, evolutionary genetic analysis of TaHKT1;5 gene and evaluation of salinity stress in selected lines of wheat.
|
genetics
|
The Bcvic1 and Bcvic2 vegetative incompatibility genes in Botrytis cinerea encode proteins with domain architectures involved in allorecognition in other filamentous fungi
|
genetics
|
Combining GWAS and TWAS to identify candidate causal genes for tocochromanol levels in maize grain
|
genetics
|
Loss-of-function mutations in novel triacylglycerol lipase genes are associated with low rancidity in pearl millet flour
|
biochemistry
|
Protein-Peptide Turnover Profiling reveals wiring of phosphorylation during protein maturation
|
biochemistry
|
Evolutionary adaptation of the folding pathway for secretability
|
biochemistry
|
Near-neutral pH increased n-caprylate production in a microbiome with product inhibition of methanogenesis
|
bioengineering
|
Prediction of designer-recombinases for DNA editing with generative deep learning
|
bioinformatics
|
Viability of AMURA biomarkers from single-shell diffusion MRI in Migraine Clinical Studies
|
neuroscience
|
Unravelling specific diet and gut microbial contributions to inflammatory bowel disease
|
microbiology
|
Saving the Devils is in the details: Tasmanian Devil facial tumor disease can be eliminated with interventions
|
ecology
|
Population estimation of a cryptic moss frog using acoustic spatially explicit capture recapture
|
ecology
|
Fungal States of Minds
|
animal behavior and cognition
|
Rapid loss of fine motor skills after low dose space radiation exposure
|
animal behavior and cognition
|
Nonlethal effects of predation: Presence of insectivorous birds affects the behaviour and level of stress in insects
|
animal behavior and cognition
|
A Miniaturized 3D-Printed Pressure Regulator (μPR) for Microfluidic Cell Culture Applications
|
bioengineering
|
Thermal Effects on Neurons During Stimulation of the Brain
|
biophysics
|
Scanning Single Molecule Localization Microscopy (scanSMLM) for super-resolution optical volume imaging
|
biophysics
|
Simultaneous adjustments of major mitochondrial pathways through redox regulation of dihydrolipoamide dehydrogenase (mtLPD1)
|
plant biology
|
Active emulsions in living cell membranes driven by contractile stresses and transbilayer coupling
|
cell biology
|
Gain-of-function genetic screens in human cells identify SLC transporters overcoming environmental nutrient restrictions
|
cell biology
|
A comparison of feature selection methodologies and learning algorithms in the development of a DNA methylation-based telomere length estimator
|
bioinformatics
|
Vimentin Intermediate Filaments Can Enhance or Abate Active Cellular Forces in a Microenvironmental Stiffness-Dependent Manner
|
biophysics
|
Perturbed actin cap and nuclear morphology in primary fibroblasts of Huntington's disease patients as a new phenotypic marker for personalized drug evaluation
|
cell biology
|
Integrative analysis of metabolite GWAS illuminates the molecular basis of pleiotropy and genetic correlation
|
genomics
|
A brain-inspired object-based attention network for multi-object recognition and visual reasoning
|
animal behavior and cognition
|
Growth rate controls the sensitivity of gene regulatory circuits
|
systems biology
|
Dominance vs. epistasis: the biophysical origins and plasticity of genetic interactions within and between alleles
|
genetics
|
Antibodies to Coagulase of Staphylococcus aureus crossreact to Efb and reveal different binding of shared Fibrinogen Binding repeats
|
biochemistry
|
Tegaserod maleate suppresses the growth of gastric cancer in vivo and in vitro by targeting MEK1/2
|
pathology
|
Toxicity of extracellular alpha-synuclein is independent of intracellular alpha-synuclein
|
neuroscience
|
Accumulated 3-phosphoglycerate in darkness is a primary starting substrate for stepwise photosynthetic induction process in cyanobacteria
|
plant biology
|
Emergence and clonal expansion in Europe of Vibrio aestuarianus lineages pathogenic for oysters
|
microbiology
|
Anatomy and Symbiosis of the digestive system of the vent shrimps Rimicaris exoculata and Rimicaris chacei revealed through imaging approaches.
|
microbiology
|
Evolutionary relations between mycorrhizal symbiosis and plant-plant communication in trees
|
ecology
|
Genomic insights into present local adaptation and future climate change vulnerability of a keystone forest tree species in East Asian
|
evolutionary biology
|
Genomic regions associate with major axes of variation in gas exchange and leaf construction traits in cultivated sunflower (Helianthus annuus L.)
|
plant biology
|
Combined drought resistance strategies and the hydraulic limit in co-existing Mediterranean woody species
|
plant biology
|
Cellular dynamics of endosperm development in Arabidopsis thaliana
|
plant biology
|
A scalable phenotyping approach for female floral organ development and senescence in the absence of pollination in wheat
|
plant biology
|
Toxoplasma gondii Coq1 is a heptaprenyl diphosphate synthase and its inhibition by a lipophilic bisphosphonate protects mice against T. gondii infection
|
microbiology
|
Intracellular acidification is a hallmark of thymineless death in E. coli
|
microbiology
|
Unique genomic sequences in novel Mycobacterium avium subsp. hominissuis lineage enabled fine scale tracing the transmission route during pig movement
|
microbiology
|
Differential pathogenesis of SARS-CoV-2 variants of concern in human ACE2-expressing mice
|
microbiology
|
Neuroendocrine control of the proteostatic network by HPK-1 delays aging
|
genetics
|
Transmembrane helices 5 and 12 control transport dynamics, substrate affinity and specificity in the elevator-type UapA transporter
|
genetics
|
Structure and function of a Notch-like proteolytic switch domain in the extracellular matrix receptor dystroglycan
|
biochemistry
|
Unbreakable DNA tension probes show that cell adhesion receptors detect the molecular force-extension curve of their ligands
|
biophysics
|
Multistate structures of the MLL1-WRAD complex bound to H2B-ubiquitinated nucleosome
|
biophysics
|
Older circuits get richer: neurogenesis timeline shapes hubness and neurogenetic profiles of the adult human brain
|
neuroscience
|
CCR4 and CCR7 differentially regulate thymocyte subset localization with distinct outcomes for central tolerance
|
immunology
|
Identification and functional characterization of two heme uptake systems required for virulence of the fish pathogen Flavobacterium psychrophilum
|
microbiology
|
Modulation of the gut microbiome by novel synthetic glycans for the production of propionate and the reduction of cardiometabolic risk factors
|
microbiology
|
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