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A novel anti-PD-L1/IL-15 immunocytokine overcomes resistance to PD-L1 blockade and elicits potent antitumor immunity
|
immunology
|
Broad neutralization of SARS-CoV-2 variants by circular mRNA producing VFLIP-X spike in mice
|
immunology
|
High-resolution secretory timeline from vesicle formation at the Golgi to fusion at the plasma membrane in S. cerevisiae
|
cell biology
|
Development of a novel high-throughput screen for the identification of new inhibitors of protein S-acylation
|
cell biology
|
AtEH/Pan1 proteins drive phase separation of the TPLATE complex and clathrin polymerisation during plant endocytosis
|
cell biology
|
Mother cells control daughter cell proliferation in intestinal organoids to minimize proliferation fluctuations
|
cell biology
|
Substrate trapping approach identifies TRIM25 ubiquitination targets involved in diverse cellular and antiviral processes
|
cell biology
|
En1 and Lmx1b do not recapitulate embryonic dorsal-ventral limb patterning functions during mouse digit tip regeneration
|
developmental biology
|
Sea anemone Frizzled receptors play partially redundant roles in the oral-aboral axis patterning
|
developmental biology
|
Differential expression of Nanog 3UTR and coding region mRNA components defines an embryonic stem cell niche
|
developmental biology
|
Inherent dynamics of maltose binding protein (MBP) are immune to the native environment.
|
biophysics
|
Gill developmental program in the teleost mandibular arch
|
developmental biology
|
A non-invasive method for time-lapse imaging of microbial interactions and biofilm dynamics
|
microbiology
|
A bipartite, low-affinity roadblock domain-containing GAP complex regulates bacterial front-rear polarity
|
microbiology
|
Acute Cytomegalovirus Infection Modulates the Intestinal Microbiota and Targets Intestinal Epithelial Cells
|
microbiology
|
Transcriptome analysis of alcohol dependence and stress interactions in the nucleus of the solitary tract
|
molecular biology
|
Arginine 65 methylation of Neurogenin 3 by PRMT1 is a prerequisite for development of hESCs into pancreatic endocrine cells
|
developmental biology
|
Evaluating the potential benefits and pitfalls of combining protein and expression quantitative trait loci in evidencing drug targets
|
genetics
|
Structure and functional mapping of the KRAB-KAP1 repressor complex
|
biochemistry
|
Eight week dietary inclusion of nitrite-containing frankfurter exacerbates colorectal cancer pathology, increases oxidative stress, alters metabolism and causes gut dybiosis in APCmin mice
|
biochemistry
|
Structure of a Rad52 homolog from bacteriophage in complex with a novel duplex intermediate of DNA annealing
|
biochemistry
|
Groundwater metabolome responds to recharge in fractured sedimentary strata
|
biochemistry
|
Visualizing the Transiently Populated Closed-State of Human HSP90 ATP Binding Domain
|
biophysics
|
A microfluidic platform to investigate the role of mechanical constraints on tissue reorganization
|
biophysics
|
Allele-specific activation, enzyme kinetics, and inhibitor sensitivities of EGFR exon 19 deletion mutations in lung cancer
|
cancer biology
|
Multivalent, Bispecific ????B7-H3-????CD3 Chemically Self-Assembled Nanorings Direct Potent T-cell Responses Against Medulloblastoma
|
cancer biology
|
Stress-tolerant, recyclable, and autonomously renewable biocatalyst platform enabled by engineered bacterial spores
|
synthetic biology
|
Lineage tracing via associative chromosome/plasmid barcoding with siBar
|
microbiology
|
The faecal microbiome of the wild European badger Meles meles; a comparison against other wild omnivorous mammals from across the globe
|
microbiology
|
New features of micro-RNA regulation of mRNA translation and stability revealed by expression of targeted or not targeted reporter genes
|
molecular biology
|
Identification of Aspergillus niger aquaporins involved in hydrogen peroxide signaling
|
molecular biology
|
The Arabidopsis Hop1 homolog ASY1 mediates cross-over assurance and interference
|
cell biology
|
The DeepFaune initiative: a collaborative effort towards the automatic identification of the French fauna in camera-trap images
|
ecology
|
clampFISH 2.0 enables rapid, scalable amplified RNA detection in situ
|
bioengineering
|
Rational design of Cas9 ribonucleoprotein with a "gRNA-shRNA" for multidimensional genome manipulation and enhanced homology-directed repair
|
bioengineering
|
TidyMass: An Object-oriented Reproducible Analysis Framework for LC-MS Data
|
bioinformatics
|
Proteome reallocation enables the selective de novo biosynthesis of non-linear, branched-chain acetate esters
|
synthetic biology
|
Structure of dynein-dynactin on microtubules shows tandem recruitment of cargo adaptors
|
molecular biology
|
A correlational study between microstructural, macrostructural and functional age-related changes in the human visual cortex
|
bioengineering
|
Effects of different environmental intervention durations on the intestinal mucosal barrier and the brain-gut axis in rats with colorectal cancer
|
cancer biology
|
Fgf8 dosage regulates jaw shape and symmetry through pharyngeal-cardiac tissue relationships
|
developmental biology
|
Single-cell RNA sequencing of conditional Pten knockout neurons in mice
|
neuroscience
|
Distinct cortical responses to Auditory Statistics: pre-attentive discriminations based on local and global representations
|
neuroscience
|
Mesoaccumbal glutamate neurons drive reward via glutamate release, but aversion via dopamine co-release
|
neuroscience
|
A brain-wide analysis maps structural evolution to distinct anatomical modules
|
neuroscience
|
Surface motility favors co-dependent interaction between Pseudomonas aeruginosa and Burkholderia cenocepacia
|
microbiology
|
Genomics epidemiology analysis reveals hidden signatures of drug resistance in Mycobacterium tuberculosis
|
genomics
|
Brain-wide screen of prelimbic cortex inputs reveals a functional shift during early fear memory consolidation
|
neuroscience
|
Circulating miR-30b-5p is up regulated in Cavalier King Charles Spaniels affected by early myxomatous mitral valve disease
|
genomics
|
Genomic analyses identify key molecules and significant signaling pathways in Sorafenib treated hepatocellular cancer cells
|
bioinformatics
|
Tempo: an unsupervised Bayesian algorithm for circadian phase inference in single-cell transcriptomics
|
bioinformatics
|
The Trichloroethylene Metabolite S-(1,2-dichlorovinyl)-l-cysteine Inhibits Lipopolysaccharide-induced Transcriptomic Inflammation Pathways and Cytokine Secretion in a Macrophage Cell Model
|
pharmacology and toxicology
|
Feature-based attention multiplicatively scales the fMRI-BOLD contrast-response function
|
neuroscience
|
NFAT5 induction by the tumor microenvironment enforces CD8 T cell exhaustion
|
immunology
|
Are trapping data still suited for home range estimation? An analysis with various estimators, asymptotic models and data ordering procedures
|
ecology
|
The use of pigs vocalisation structure to assess the quality of human-pig relationship
|
animal behavior and cognition
|
Cavitation Induced Fracture of Intact Brain Tissue
|
bioengineering
|
A systematic comparison of current bioinformatic tools for glycoproteomics data
|
bioinformatics
|
Unsupervised discovery of tissue architecture in multiplexed imaging
|
bioinformatics
|
Adversarial attacks and adversarial robustness in computational pathology
|
bioinformatics
|
metaPathwayMap: A tool to predict metabolic pathway neighborhoods from structural classes of untargeted metabolomics peaks
|
bioinformatics
|
Dynamic play between human N-α-acetyltransferase D and H4-mutant histones: Molecular dynamics study
|
biophysics
|
Dual blockade of misfolded alpha-sarcoglycan degradation by bortezomib and givinostat combination
|
pharmacology and toxicology
|
GIP receptor agonism improves dyslipidemia and atherosclerosis independently of body weight in obese mice
|
pharmacology and toxicology
|
Like host, like parasite: intraspecific divergence in a polystomatid flatworm parasite across South Africa echoes that of its frog host
|
zoology
|
Electroencephalography-derived functional connectivity in sensorimotor networks in Stroke and Multiple Sclerosis Fatigue
|
neuroscience
|
Sst+ GPi output neurons provide direct feedback to key nodes of the basal ganglia and drive behavioral flexibility.
|
neuroscience
|
Microglial P2Y12 mediates chronic stress-induced synapse loss in the prefrontal cortex and associated behavioral consequences in male mice
|
neuroscience
|
How Hippocampus Solves Inverse Problems: A Circuit Hypothesis
|
neuroscience
|
Comparable theta phase coding dynamics along the transverse axis of CA1
|
neuroscience
|
A flexible and versatile system for multicolor fiber photometry and optogenetic manipulation
|
neuroscience
|
Thermoregulatory Dynamics Reveal Sex-Specific Inflammatory Responses to Experimental Autoimmune Encephalomyelitis in Mice: Implications for Multiple Sclerosis-Induced Fatigue in Females
|
neuroscience
|
Saturated reconstruction of living brain tissue
|
neuroscience
|
Geometry of spiking activity in early visual cortex: a Topological Data Analytic approach
|
neuroscience
|
Glocal dendritic spikes: variation in branch activity during dendritic spiking indicates multiple functional units in the pyramidal neuron apical tuft
|
neuroscience
|
Axisymmetric diffusion kurtosis imaging with Rician bias correction: A simulation study
|
neuroscience
|
T cell migration requires ion and water influx to regulate actin polymerization
|
immunology
|
VEGFR3 modulates brain microvessel branching in a mouse model of 22q11.2 deletion syndrome
|
developmental biology
|
Sex and size matter: foraging ecology of offshore harbour porpoises in waters around Greenland
|
ecology
|
Engineering ecologically complementary rhizosphere probiotics using consortia of specialized bacterial mutants
|
ecology
|
Beyond inappropriate fire regimes: a synthesis of fire-driven declines of threatened mammals in Australia
|
ecology
|
Xanthomonas indica sp. nov., a non-pathogenic bacterium isolated from healthy rice (Oryza sativa) seeds from India
|
evolutionary biology
|
Transcriptional control of the lacZ promoter is under directional and diversifying selection
|
evolutionary biology
|
Case-only rare variant analysis of severe alcohol dependence (AD) using a multivariate hierarchical gene clustering approach.
|
genetics
|
QTLs analysis for cold tolerance in rice (Oryza sp.) at the seedling stage using F2 population developed from cross between the genotypes NERICA L-19 and Diamante
|
genetics
|
DNA methylation signatures of Alzheimer's disease neuropathology in the cortex are primarily driven by variation in non-neuronal cell-types
|
genetics
|
Integrated protein and transcriptome high-throughput spatial profiling
|
genomics
|
Integration of visual and antennal mechanosensory feedback during head stabilization in hawkmoths
|
animal behavior and cognition
|
Optimization of the precursor supply for an enhanced FK-506 production in Streptomyces tsukubaensis
|
bioengineering
|
3D Bioprinted perfusable and vascularized breast tumor model for dynamic screening of chemotherapeutics and CAR-T cells
|
bioengineering
|
Case-control analysis of single-cell RNA-seq studies
|
bioinformatics
|
Drug Mechanism Enrichment Analysis: A tool to link molecular signatures with sensitivity to drug mechanisms of action
|
bioinformatics
|
EsMeCaTa: Estimating metabolic capabilities from taxonomic affiliations
|
bioinformatics
|
Feature selection and aggregation for antibiotic resistance GWAS in Mycobacterium tuberculosis: a comparative study.
|
bioinformatics
|
-Labeled PARP-1 PET Imaging of PSMA Targeted Alpha Particle Radiotherapy Response
|
cancer biology
|
Comparison of co-immunoprecipitation techniques for effective identification of SNTA1 interacting proteins in breast cancer cells
|
cancer biology
|
SciCV, the Swiss National Science Foundation's new CV format
|
scientific communication and education
|
Robust group- but limited individual-level (longitudinal) reliability and insights into cross-phases response prediction of conditioned fear
|
neuroscience
|
Resolving the mesoscopic missing link: Biophysical modeling of EEG from cortical columns in primates
|
neuroscience
|
Tuning of motor outputs produced by spinal stimulation during voluntary control of torque directions in monkeys
|
neuroscience
|
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