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Peptide derived nanobody inhibits entry of SARS-CoV-2 variants
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cell biology
|
The kinase activity of the cancer stem cell marker DCLK1 drives gastric cancer progression by reprogramming the stromal tumor landscape
|
cancer biology
|
Explosive seed dispersal depends on SPL7 to ensure sufficient copper for localized lignin deposition via laccases
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plant biology
|
Potato virus X -delivered CRISPR activation programs lead to strong endogenous gene induction and transient metabolic reprogramming in Nicotiana benthamiana.
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synthetic biology
|
Cholesterol binds the amphipathic helix of IFITM3 and regulates antiviral activity
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immunology
|
Prefusion-Stabilized Lassa Virus Trimer Identifies Neutralizing Nanobodies and Reveals an Apex-Situated Site of Vulnerability
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immunology
|
The AraC/XylS protein MxiE and its co-regulator IpgC control a negative feedback loop in the transcriptional cascade that regulates type III secretion in Shigella flexneri
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microbiology
|
The PqsE active site as a target for small molecule antimicrobial agents against Pseudomonas aeruginosa
|
microbiology
|
The licorice metabolite enoxolone attenuates Clostridioides difficile pathophysiology by corrupting its metabolic and toxin production networks
|
microbiology
|
Integrative assessment of the transcriptome and virome of the poultry red mite Dermanyssus gallinae.
|
microbiology
|
Disentangling the lipid divide: Identification of key enzymes for the biosynthesis of unusual Membrane-spanning and Ether lipids in Bacteria
|
microbiology
|
Towards Synthetic PETtrophy: Engineering Pseudomonas putida for concurrent polyethylene terephthalate (PET) monomer metabolism and PET hydrolase expression
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microbiology
|
RNA Pol II pausing facilitates phased pluripotency transitions by buffering transcription
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molecular biology
|
CLN7 mutation causes aberrant redistribution of protein isoforms and contributes to Batten disease pathobiology
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cell biology
|
FGF signaling promotes precursor spreading for adult adipogenesis in Drosophila
|
developmental biology
|
Rapid evolution of sex role specialization in a hermaphrodite under sex-limited selection
|
evolutionary biology
|
Human pancreatic islet microRNAs implicated in diabetes and related traits by large-scale genetic analysis
|
genetics
|
Maintenance of quantitative genetic variance in complex, multi-trait phenotypes: The contribution of rare, large effect variants in two Drosophila species
|
genetics
|
Regulation of Liprin-α phase separation by CASK is disrupted by a mutation in its CaM kinase domain
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genetics
|
Reporter gene assays and chromatin-level assays define substantially non-overlapping sets of enhancer sequences
|
genomics
|
Conservation and divergence of canonical and non-canonical imprinting in murids
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genomics
|
Spatial chromatin accessibility sequencing resolves next-generation genome architecture
|
genomics
|
DiffBrainNet: differential analyses add new insights into the response to glucocorticoids at the level of genes, networks and brain regions
|
genomics
|
A platform for efficient establishment, expansion and drug response profiling of high-grade serous ovarian cancer organoids
|
cancer biology
|
rTg(TauP301L)4510 mice exhibit increased VGLUT1 in hippocampal presynaptic glutamatergic vesicles and increased extracellular glutamate release
|
neuroscience
|
Synaptotagmin 7 docks synaptic vesicles for Doc2α-triggered asynchronous neurotransmitter release
|
neuroscience
|
Birth and Death in Terminal Complement Pathway
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immunology
|
Drosophila immunity: The Drosocin gene encodes two host defence peptides with pathogen-specific roles
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immunology
|
Yield Stress and Creep Control Depot Formation and Persistence of Injectable Hydrogels Following Subcutaneous Administration
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bioengineering
|
Low temperature induced quiescence in parasitoids Trichogramma evanescens Westwood and Trichogramma chilonis Ishii reared on Plodia interpunctella (Hübner): Its utilization as quality control for mass rearing
|
zoology
|
Neuromuscular denervation and deafferentation but not motor neuron death are disease features in the Smn 2B/- mouse model of SMA
|
neuroscience
|
Asymmetric dysregulation of glutamate dynamics across the synaptic cleft in a mouse model of Alzheimer disease
|
neuroscience
|
Breakpoint models shown no evidence of thresholds in recreational response to increasing wildfire smoke in the American West
|
ecology
|
Private and sub-family specific mutations of founder haplotypes in the BXD family reveal phenotypic consequences relevant to health and disease
|
genomics
|
Improving the assessment of deep learning models in the context of drug-target interaction prediction
|
bioinformatics
|
Comparative transcriptomics and metabolomics reveal specialized metabolite drought stress responses in switchgrass (Panicum virgatum L.)
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plant biology
|
Microbiota-induced active translocation of peptidoglycan across the intestinal barrier dictates its within-host dissemination
|
microbiology
|
McaA and McaB control the dynamic positioning of a bacterial magnetic organelle
|
microbiology
|
Diversity of Secretion System Apparatus in Tomato Wilt Causing Ralstonia solanacearum Strains: a Comparative Analysis Using in-silico Approach
|
microbiology
|
Improved assessments of milk microbiota composition via sample preparation and DNA extraction methods
|
microbiology
|
Transient developmental increase in cortical projections to amygdala GABAergic neurons contribute to circuit dysfunction following early life stress
|
neuroscience
|
Cerebral activity in monkeys Papio anubis during the perception of conspecific and heterospecific agonistic vocalizations: A functional Near Infrared Spectroscopy study
|
neuroscience
|
Molecular-enriched functional connectivity in the human brain using multiband multi-echo simultaneous ASL/BOLD fMRI
|
neuroscience
|
Pallidal neuromodulation of the explore/exploit trade-off in decision-making
|
neuroscience
|
Architecture and Assembly Mechanism of Human LACTB
|
biophysics
|
Apurinic/apyrimidinic nuclease 1 drives genomic evolution contributing to chemoresistance and tumorigenesis in solid tumor
|
cancer biology
|
The nanoCUT&RUN technique visualizes telomeric chromatin in Drosophila
|
genetics
|
Bridging scales from spiking activity to the local field potential through latent dynamics
|
neuroscience
|
A three-photon head-mounted microscope for imaging all layers of visual cortex in freely moving mice.
|
neuroscience
|
Neural resources shift under Methylphenidate: a computational approach to examine anxiety-cognition interplay
|
neuroscience
|
Upregulated Ca2+ release from the endoplasmic reticulum leads to impaired presynaptic function in Alzheimer's disease
|
neuroscience
|
Mind the gap: decoding decreases in tonic firing in populations of spiking neurons
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neuroscience
|
Atlantic cod as an indicator of rapid climate change
|
ecology
|
Macroecological variation in movement profiles: body size does not explain it all
|
ecology
|
Mitigating pseudoreplication and bias in resource selection functions with autocorrelation-informed weighting
|
ecology
|
Seasonal movement of royal chambers: where are the kings and queens of temperate termites in winter?
|
ecology
|
Mitochondrial effects on fertility and longevity in Tigriopus californicus contradict predictions of the mother's curse hypothesis
|
evolutionary biology
|
A comprehensive Bioconductor ecosystem for the design of CRISPR guide RNAs across nucleases and technologies
|
bioinformatics
|
Xlink Mapping and AnalySis (XMAS) - Smooth Integrative Modeling in ChimeraX
|
bioinformatics
|
DrugRepo: A novel approach to repurpose a huge collection of compounds based on chemical and genomic features
|
bioinformatics
|
Detecting intragenic trans-splicing events with hybrid transcriptome sequencing in cancer cells
|
bioinformatics
|
Modelling eNvironment for Isoforms (MoNvIso): A general platform to predict structural determinants of protein isoforms in genetic diseases
|
bioinformatics
|
In silico identification of novel peptides as potential modulators of Aβ42 Amyloidogenesis
|
bioinformatics
|
Inducible lncRNA transgenic mice reveal continual role of HOTAIR in promoting breast cancer metastasis
|
cancer biology
|
Motor pattern generation is robust to neural network anatomical imbalance favoring inhibition but not excitation
|
neuroscience
|
Tbx3 is required for mammalian retinal angiogenesis.
|
neuroscience
|
Differential regulation of gene expression pathways with dexamethasone and ACTH after early life seizures
|
neuroscience
|
Combining Stem Cell Rejuvenation and Senescence Targeting to Synergistically Extend Lifespan
|
developmental biology
|
Fluid manipulations uncover mechanosensation for zebrafish left-right establishment during one-hour time interval
|
developmental biology
|
Why the architecture of environmental fluctuation matters for fitness
|
ecology
|
Landscape change and alien invasions drive shifts in native lady beetle communities over a century
|
ecology
|
Rising Temperature Drives Tipping Points in Mutualistic Networks
|
ecology
|
Evaluating risk-taking behaviors in Lycosidae: are the nutritional benefits of sugar water worth the risk of predation?
|
animal behavior and cognition
|
UMINT: Unsupervised Neural Network For Single Cell Multi-Omics Integration
|
bioinformatics
|
Systems-level identification of key transcription factors in immune cell specification
|
systems biology
|
GABAergic regulation of cell proliferation within the adult mouse spinal cord
|
neuroscience
|
Dissection of a sensorimotor circuit that regulates aversion to odors and pathogenic bacteria in C. elegans by whole-brain simulation
|
neuroscience
|
A highly diverse set of novel immunoglobulin-like transcript (NILT) genes in zebrafish indicates a wide range of functions with complex relationships to mammalian receptors
|
immunology
|
Divergent acute versus prolonged in vivo GLP-1R responses in β-arrestin 2-deleted primary beta cells
|
cell biology
|
Population genomics of the island thrush elucidates one of earth's great archipelagic radiations
|
evolutionary biology
|
A Fast, Provably Accurate Approximation Algorithm for Sparse Principal Component Analysis Reveals Human Genetic Variation Across the World
|
genomics
|
OptoRheo: Simultaneous in situ micro-mechanical sensing and 3D imaging of live cell cultures
|
bioengineering
|
CAPG: Comprehensive Allopolyploid Genotyper
|
bioinformatics
|
Glucagon-Like Peptide-1 Receptor Activation Stimulates PKA-Mediated Phosphorylation of Raptor and this Contributes to the Weight Loss Effects of Liraglutide
|
physiology
|
Resilience in soil bacterial communities of the boreal forest from one to five years after wildfire across a severity gradient
|
ecology
|
Accurate and sensitive mutational signature analysis with MuSiCal
|
genomics
|
Computational modeling of deep tissue heating by an automatic thermal massage bed: predicting the effects on circulation
|
bioengineering
|
Odorant molecular feature mining by diverse deep neural networks for prediction of odor perception categories
|
bioinformatics
|
Great tits differ in glucocorticoid plasticity in response to spring temperature
|
physiology
|
Learning High-Order Interactions for Polygenic Risk Prediction
|
genomics
|
Benchmarking brain organoid recapitulation of fetal corticogenesis
|
developmental biology
|
Gene Transfer based Phylogenetics: Analytical Expressions and Additivity via Birth/Death Theory
|
evolutionary biology
|
Does fatigue influence joint-specific work and ground force production during the first steps of maximal accelerative running?
|
biophysics
|
Deceptive learning in histopathology
|
pathology
|
Heavy metals in moss guide environmental justice investigation: a case study using community science in Seattle, WA, USA
|
scientific communication and education
|
Cluster-Based Inference for Memory-Based Cognition
|
neuroscience
|
VelcroVax: a bolt-on vaccine platform technology improves antibody titres against a viral glycoprotein in mice
|
immunology
|
enclone: precision clonotyping and analysis of immune receptors
|
immunology
|
Sex differences in NK cells mediated by the X-linked epigenetic regulator UTX
|
immunology
|
Targeted single-cell genomics reveals novel host adaptation strategies of the symbiotic bacteria Endozoicomonas in Acropora tenuis coral
|
microbiology
|
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