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https://en.wikipedia.org/wiki/Stanley%20Gene
Stanley Gene (born 11 May 1974) is a Papua New Guinean former rugby league Kumul (#166) player and Assistant Coach of the Hull F.C.. He previously coached Gateshead Thunder and assistant coach at Hull Kingston Rovers and served as the Papua New Guinea Kumuls head coach in 2010. Having moved to England following an impressive showing for PNG in the 1995 Rugby League World Cup, Gene enjoyed a long career in the British game with spells at Hull Kingston Rovers, Huddersfield Giants, Bradford Bulls, Hull F.C. and Halifax. Gene was a versatile player with the ability to cover virtually any position on the pitch, though he spent most of his test career playing at stand off (off-half). He was a regular for the PNG Kumuls for 14 years between 1994 and 2008, and captained the side on at least three occasions, including being the PNG captain during the 2008 Rugby League World Cup, before retiring from international rugby league following the 2008 tournament. Gene is considered a hero in his home country and almost universally regarded as a rugby league legend. Career Club career Gene was born in Goroka. After playing in the 1995 Rugby League World Cup for Papua New Guinea, Gene was offered a contract to play for Hull Kingston Rovers in the old Second Division. After moving to the United Kingdom, Gene played for Hull KR from 1996 to 2000. He scored 94 Tries in 111 matches during that period, and was a massively popular figure at the club. He moved to Gateshead and was then forced to
https://en.wikipedia.org/wiki/Death%20of%20Slobodan%20Milo%C5%A1evi%C4%87
On 11 March 2006, former Yugoslav president Slobodan Milošević died in his prison cell of a heart attack at age 64 while being tried for war crimes at the International Criminal Tribunal for the Former Yugoslavia (ICTY) in The Hague. Milošević's four-year trial had been a major international news story, and he died a few months before its verdict was due. His death occurred shortly after the Tribunal rejected his request to seek specialized medical treatment at a cardiology clinic in Moscow. A report published on 30 May 2006 confirmed that he had died of natural causes and that there was "no poison or other chemical substance found in his body that contributed to the death". Establishment of death Milošević was found dead in his cell on 11 March 2006 in the UN war crimes tribunal's detention centre in the Scheveningen section of The Hague. An official in the chief prosecutor's office said that Milošević had been found at about 10 a.m. and had apparently been dead for several hours. His trial had been due to resume on 14 March with testimony from the former president of Montenegro, Momir Bulatović. A request for the autopsy in the presence of a Serbian pathologist was granted, and his body was transported to the Dutch Forensic Institute. It was established that Milošević died of a heart attack. Suspicions have been voiced: that he was deliberately given the wrong medication, causing the heart attack (Milošević had claimed to have been given the wrong medication three days b
https://en.wikipedia.org/wiki/APOBEC3G
APOBEC3G (apolipoprotein B mRNA editing enzyme, catalytic subunit 3G) is a human enzyme encoded by the APOBEC3G gene that belongs to the APOBEC superfamily of proteins. This family of proteins has been suggested to play an important role in innate anti-viral immunity. APOBEC3G belongs to the family of cytidine deaminases that catalyze the deamination of cytidine to uridine in the single stranded DNA substrate. The C-terminal domain of A3G renders catalytic activity, several NMR and crystal structures explain the substrate specificity and catalytic activity. APOBEC3G exerts innate antiretroviral immune activity against retroviruses, most notably HIV, by interfering with proper replication. However, lentiviruses such as HIV have evolved the Viral infectivity factor (Vif) protein in order to counteract this effect. Vif interacts with APOBEC3G and triggers the ubiquitination and degradation of APOBEC3G via the proteasomal pathway. On the other hand, foamy viruses produce an accessory protein Bet () that impairs the cytoplasmic solubility of APOBEC3G. The two ways of inhibition are distinct from each other, but they can replace each other in vivo. Discovery It was first identified by Jarmuz et al. as a member of family of proteins APOBEC3A to 3G on chromosome 22 in 2002 and later also as a cellular factor able to restrict replication of HIV-1 lacking the viral accessory protein Vif. Soon after, it was shown that APOBEC3G belonged to a family of proteins grouped together due
https://en.wikipedia.org/wiki/Clover%20%28detector%29
A clover detector is a gamma-ray detector that consists of 4 coaxial N-type high purity germanium (Ge) crystals each machined to shape and mounted in a common cryostat to form a structure resembling a four-leaf clover. Operation A gamma ray may interact with a single Ge crystal and deposit its full energy. The resulting charge collected will then be proportional to this energy. However, through the process of Compton scattering, a gamma ray may interact with two (or possibly more) crystals resulting in the energy (and thus the liberated charge) being shared by the crystals. In this case, a process known as add-back, where the charge collected by each of the crystals is summed, can be used to determine the energy of the incident gamma ray. Advantages There are a number of advantages offered by using clover detectors as opposed to the more conventional single crystal germanium detectors. Large volume high purity single crystals of Ge can be expensive. By mounting four smaller crystals in a common cryostat a detector of a given volume can be created at a reduced cost. In addition, the individual smaller Ge crystals present a smaller solid angle than a large volume Ge detector thus significantly reducing the effects of Doppler broadening on the resulting spectra. A clover detector can also be used to determine the electric or magnetic nature of the incident photons (e.g. if the gamma ray is an electric quadrupole or a magnetic dipole) as the Compton scattering process for thes
https://en.wikipedia.org/wiki/PEG-16%20macadamia%20glycerides
PEG-16 macadamia glycerides is the polyethylene glycol derivative of the mono- and diglycerides derived from macadamia nut oil by ethoxylation with an average of ethylene glycol units. PEG-16 macadamia glycerides are commonly used in cosmetic formulations as an emollient, refatter, conditioner, solubilizer, and secondary emulsifier. References Cosmetics chemicals
https://en.wikipedia.org/wiki/Apolipoprotein%20C-II
Apolipoprotein C-II (Apo-CII, or Apoc-II), or apolipoprotein C2 is a protein that in humans is encoded by the gene. The protein encoded by this gene is secreted in plasma, where it is a component of very low density lipoproteins and chylomicrons. This protein activates the enzyme lipoprotein lipase in capillaries, which hydrolyzes triglycerides and thus provides free fatty acids for cells. Mutations in this gene cause hyperlipoproteinemia type IB, characterized by xanthomas, pancreatitis, and hepatosplenomegaly, but no increased risk for atherosclerosis. Lab tests will show elevated blood levels of triglycerides, cholesterol, and chylomicrons Interactive pathway map See also Apolipoprotein C References External links Apolipoproteins
https://en.wikipedia.org/wiki/Pericline
Pericline also refers to a doubly plunging anticline or syncline. Pericline is a form of albite exhibiting elongate prismatic crystals. Pericline twinning is a type of crystal twinning which show fine parallel twin laminae typically found in the alkali feldspars microcline. The twinning results from a structural transformation between high temperature and low temperature forms. References Crystallography Tectosilicates
https://en.wikipedia.org/wiki/Olm%20%28disambiguation%29
The olm (Proteus anguinus) is a species of amphibian. Olm may also refer to: Ocular larva migrans, an eye disease Oil life monitor Olm (and Megolm) is a cryptographic algorithm used by Matrix (protocol) Olm, Luxembourg OLM, Inc., formerly Oriental Light and Magic, a Japanese animation studio Hans Werner Olm, German comedy artist The Olms, a musical group made up of Pete Yorn and J.D. King Olympia Regional Airport (IATA code) Ordre Libanais Maronite, the Lebanese Maronite Order, religious order Ordo Lectionum Missae, a Roman Catholic liturgical lectionary Congregation of the Sisters of Our Lady of Mercy
https://en.wikipedia.org/wiki/Jojoba%20wax%20esters
Jojoba wax esters are polyethylene glycol derivatives of the acids and alcohols obtained from the saponification of jojoba oil. With an average ethoxylation value of 80, it is known as jojoba wax PEG-80 esters or PEG-80 jojoba. With an average ethoxylation value of 120, it is known as jojoba wax PEG-120 esters or PEG-120 jojoba. Jojoba wax esters are used in cosmetic formulations as emollients. References Cosmetics chemicals
https://en.wikipedia.org/wiki/Extremal%20optimization
Extremal optimization (EO) is an optimization heuristic inspired by the Bak–Sneppen model of self-organized criticality from the field of statistical physics. This heuristic was designed initially to address combinatorial optimization problems such as the travelling salesman problem and spin glasses, although the technique has been demonstrated to function in optimization domains. Relation to self-organized criticality Self-organized criticality (SOC) is a statistical physics concept to describe a class of dynamical systems that have a critical point as an attractor. Specifically, these are non-equilibrium systems that evolve through avalanches of change and dissipations that reach up to the highest scales of the system. SOC is said to govern the dynamics behind some natural systems that have these burst-like phenomena including landscape formation, earthquakes, evolution, and the granular dynamics of rice and sand piles. Of special interest here is the Bak–Sneppen model of SOC, which is able to describe evolution via punctuated equilibrium (extinction events) – thus modelling evolution as a self-organised critical process. Relation to computational complexity Another piece in the puzzle is work on computational complexity, specifically that critical points have been shown to exist in NP-complete problems, where near-optimum solutions are widely dispersed and separated by barriers in the search space causing local search algorithms to get stuck or severely hampered. It wa
https://en.wikipedia.org/wiki/Levene%27s%20test
In statistics, Levene's test is an inferential statistic used to assess the equality of variances for a variable calculated for two or more groups. Some common statistical procedures assume that variances of the populations from which different samples are drawn are equal. Levene's test assesses this assumption. It tests the null hypothesis that the population variances are equal (called homogeneity of variance or homoscedasticity). If the resulting p-value of Levene's test is less than some significance level (typically 0.05), the obtained differences in sample variances are unlikely to have occurred based on random sampling from a population with equal variances. Thus, the null hypothesis of equal variances is rejected and it is concluded that there is a difference between the variances in the population. Some of the procedures typically assuming homoscedasticity, for which one can use Levene's tests, include analysis of variance and t-tests. Levene's test is sometimes used before a comparison of means, informing the decision on whether to use a pooled t-test or the Welch's t-test. However, it was shown that such a two-step procedure may markedly inflate the type 1 error obtained with the t-tests and thus should not be done in the first place. Instead, the choice of pooled or Welch's test should be made a priori based on the study design. Levene's test may also be used as a main test for answering a stand-alone question of whether two sub-samples in a given population ha
https://en.wikipedia.org/wiki/Mu%20wave
The sensorimotor mu rhythm, also known as mu wave, comb or wicket rhythms or arciform rhythms, are synchronized patterns of electrical activity involving large numbers of neurons, probably of the pyramidal type, in the part of the brain that controls voluntary movement. These patterns as measured by electroencephalography (EEG), magnetoencephalography (MEG), or electrocorticography (ECoG), repeat at a frequency of 7.5–12.5 (and primarily 9–11) Hz, and are most prominent when the body is physically at rest. Unlike the alpha wave, which occurs at a similar frequency over the resting visual cortex at the back of the scalp, the mu rhythm is found over the motor cortex, in a band approximately from ear to ear. People suppress mu rhythms when they perform motor actions or, with practice, when they visualize performing motor actions. This suppression is called desynchronization of the wave because EEG wave forms are caused by large numbers of neurons firing in synchrony. The mu rhythm is even suppressed when one observes another person performing a motor action or an abstract motion with biological characteristics. Researchers such as V. S. Ramachandran and colleagues have suggested that this is a sign that the mirror neuron system is involved in mu rhythm suppression, although others disagree. The mu rhythm is of interest to a variety of scholars. Scientists who study neural development are interested in the details of the development of the mu rhythm in infancy and childhood and
https://en.wikipedia.org/wiki/Ecological%20indicator
Ecological indicators are used to communicate information about ecosystems and the impact human activity has on ecosystems to groups such as the public or government policy makers. Ecosystems are complex and ecological indicators can help describe them in simpler terms that can be understood and used by non-scientists to make management decisions. For example, the number of different beetle taxa found in a field can be used as an indicator of biodiversity. Many different types of indicators have been developed. They can be used to reflect a variety of aspects of ecosystems, including biological, chemical and physical. Due to this variety, the development and selection of ecological indicators is a complex process. Using ecological indicators is a pragmatic approach since direct documentation of changes in ecosystems as related to management measures, is cost and time intensive. For example, it would be expensive and time-consuming to count every bird, plant and animal in a newly restored wetland to see if the restoration was a success. Instead, a few indicator species can be monitored to determine the success of the restoration. "It is difficult and often even impossible to characterize the functioning of a complex system, such as an eco-agrosystem, by means of direct measurements. The size of the system, the complexity of the interactions involved, or the difficulty and cost of the measurements needed are often crippling" The terms ecological indicator and environment
https://en.wikipedia.org/wiki/There%27s%20No%20Other%20%28Like%20My%20Baby%29
"There's No Other (Like My Baby)" is a song first recorded in 1961 by American girl group the Crystals. Written by Phil Spector and Leroy Bates. Also produced by Spector, the single was the first release on his newly-founded Philles Records label. Barbara Alston sang lead vocal, as she did on the next two Crystals releases "Uptown" and "He Hit Me (It Felt Like a Kiss)". Spector neglected to pay the Crystals for their work on "There's No Other". Their debut single, "There's No Other (Like My Baby)" debuted on the Billboard Hot 100 in November 1961 and peaked at number 20 in January 1962 during its 11-week chart run. In 1965, the song was covered by the Beach Boys on their album Beach Boys' Party! and subsequently issued as the B-side to their single "The Little Girl I Once Knew". Cash Box described the Beach Boys' version as getting a "laconic, slow-shufflin’ reading." References Song recordings produced by Phil Spector Songs written by Phil Spector 1961 songs Philles Records singles
https://en.wikipedia.org/wiki/IMP-16
The IMP-16, by National Semiconductor, was the first multi-chip 16-bit microprocessor, released in 1973. It consisted of five PMOS integrated circuits: four identical RALU chips, short for register and ALU, providing the data path, and one CROM, Control and ROM, providing control sequencing and microcode storage. The IMP-16 is a bit-slice processor; each RALU chip provides a 4-bit slice of the register and arithmetic that work in parallel to produce a 16-bit word length. Each RALU chip stores its own 4 bits of the program counter, several registers, the ALU, a 16-word LIFO stack, and status flags. There were four 16-bit accumulators, two of which could be used as index registers. The instruction set architecture was similar to that of the Data General Nova. The chip set could be extended with the CROM chip (IMP-16A / 522D) that implemented 16-bit multiply and divide routines. The chipset was driven by a two-phase 715 kHz non-overlapping clock that had a +5 to -12 voltage swing. An integral part of the architecture was a 16-bit input mux that provided various condition bits from the ALUs such as zero, carry, overflow along with general purpose inputs. The microprocessor was used in the IMP-16P microcomputer and Jacquard Systems' J100 but saw little other use. The IMP-16 was later superseded by the PACE and INS8900 single-chip 16-bit microprocessors, which had a similar architecture but were not binary compatible. It was also used in the Aston Martin Lagonda, thanks to Nati
https://en.wikipedia.org/wiki/Momentum%20%28disambiguation%29
Momentum, or linear momentum, is a vector quantity in physics. Momentum may also refer to: Economics Momentum (finance), an empirical tendency for rising asset prices to continue to rise Momentum (technical analysis), an indicator used in technical analysis of asset prices Momentum investing, a system of buying stocks or other securities Mathematics, science, and technology Angular momentum, in physics, the rotational equivalent of linear momentum Momentum or moment, a medieval unit of time Behavioral momentum, a theory and metaphor used in the quantitative analysis of behavior Momentum (electromagnetic simulator), a software package from EEsof Momentum theory, a theory in fluid mechanics Momentum, in mathematics, a correction term in gradient descent and stochastic gradient descent Momentum, a solar car built in 2005 by the University of Michigan Solar Car Team Arts and entertainment Film Momentum (1992 film), a documentary short, the first film shot and released in the IMAX HD format Momentum (2001 film), a surfing documentary Momentum (2003 film), an American-German science fiction television film Momentum (2015 film), a South African action-thriller film Momentum Pictures, UK motion picture distributor Music Albums Momentum (Bill Evans album), 2012 Momentum (Dave Burrell album) or the title song, 2006 Momentum (DGM album), 2013 Momentum (Jamie Cullum album), 2013 Momentum (Joshua Redman album), 2005 Momentum (Neal Morse album) or the title song
https://en.wikipedia.org/wiki/Yao%27s%20principle
In computational complexity theory, Yao's principle (also called Yao's minimax principle or Yao's lemma) is a way to prove lower bounds on the worst-case performance of randomized algorithms, by comparing them to deterministic (non-random) algorithms. It states that, for any randomized algorithm, there exists a probability distribution on inputs to the algorithm, so that the expected cost of the randomized algorithm on its worst-case input is at least as large as the cost of the best deterministic algorithm on a random input from this distribution. Thus, to establish a lower bound on the performance of randomized algorithms, it suffices to find an appropriate distribution of difficult inputs, and to prove that no deterministic algorithm can perform well against that distribution. This principle is named after Andrew Yao, who first proposed it. Yao's principle may be interpreted in game theoretic terms, via a two-player zero-sum game in which one player, Alice, selects a deterministic algorithm, the other player, Bob, selects an input, and the payoff is the cost of the selected algorithm on the selected input. Any randomized algorithm R may be interpreted as a randomized choice among deterministic algorithms, and thus as a mixed strategy for Alice. Similarly, a non-random algorithm may be thought of as a pure strategy for Alice. By von Neumann's minimax theorem, Bob has a randomized strategy that performs at least as well against R as it does against the best pure strategy Al
https://en.wikipedia.org/wiki/Tsuneko%20Okazaki
is a Japanese pioneer of molecular biology known for her work on DNA replication and specifically for discovering Okazaki fragments, along with her husband Reiji. Dr. Tsuneko Okazaki has continued to be involved in academia, contributing to more advancements in DNA research. Early life and education Tsuneko Okazaki was born in Nagoya, capital of the Aichi Prefecture of Japan, in 1933. She graduated from Aichi Prefectural Asahigaoka Senior High School. During her undergraduate years, she studied biology at Nagoya University School of Science. She graduated with her PhD from Nagoya University School of Science in 1956, which was also the year that she met her husband, Reiji Okazaki. They married that same year and soon after, they joined their research work and laboratories. Work leading to and discovery of Okazaki fragments Tsuneko and Reiji Okazaki's early research consisted of studying DNA synthesis and specific nucleotide characteristics in frog eggs and sea urchins. This work led to the discovery of thymidine-diphosphate rhamnose, a sugar linked nucleotide, which then opened up the doors for them to work in the U.S. They worked at Washington University and Stanford University in the labs of J. L. Strominger and Arthur Kornberg, respectively, where there was a lot more availability of resources to further their research. Years later, after much research done in both the U.S and Japan, in 1968, Tsuneko and Reiji published their breakthrough findings on Okazaki fragment
https://en.wikipedia.org/wiki/Caverphone
The Caverphone within linguistics and computing, is a phonetic matching algorithm invented to identify English names with their sounds, originally built to process a custom dataset compound between 1893 and 1938 in southern Dunedin, New Zealand. Started from a similar concept as metaphone, it has been developed to accommodate and process general English since then. Etymology The Caverphone was created by David Hood in the Caversham Project at the University of Otago in New Zealand in 2002, revised in 2004. It was created to assist in data matching between late 19th century and early 20th century electoral rolls, where the name only needed to be in a "commonly recognisable form". The algorithm was intended to apply to those names that could not easily be matched between electoral rolls, after the exact matches were removed from the pool of potential matches. The algorithm is optimised for accents present in the study area (southern part of the city of Dunedin, New Zealand). Procedure Caverphone 1.0 The rules of the algorithm are applied consecutively to any particular name, as a series of replacements. The algorithm is as follows: Convert to lowercase Remove anything not A-Z If the name starts with... cough, replace it by cou2f rough, replace it by rou2f tough, replace it by tou2f enough, replace it by enou2f gn, replace it by 2n If the name ends with mb, replace it by m2 Replace cq with 2q ci with si ce with se cy with sy tch with 2ch c with k q with
https://en.wikipedia.org/wiki/Frequency%20%28statistics%29
In statistics, the frequency or absolute frequency of an event is the number of times the observation has occurred/recorded in an experiment or study. These frequencies are often depicted graphically or in tabular form. Types The cumulative frequency is the total of the absolute frequencies of all events at or below a certain point in an ordered list of events. The relative frequency (or empirical probability) of an event is the absolute frequency normalized by the total number of events: The values of for all events can be plotted to produce a frequency distribution. In the case when for certain , pseudocounts can be added. Depicting frequency distributions A frequency distribution shows a summarized grouping of data divided into mutually exclusive classes and the number of occurrences in a class. It is a way of showing unorganized data notably to show results of an election, income of people for a certain region, sales of a product within a certain period, student loan amounts of graduates, etc. Some of the graphs that can be used with frequency distributions are histograms, line charts, bar charts and pie charts. Frequency distributions are used for both qualitative and quantitative data. Construction Decide the number of classes. Too many classes or too few classes might not reveal the basic shape of the data set, also it will be difficult to interpret such frequency distribution. The ideal number of classes may be determined or estimated by formula: (log
https://en.wikipedia.org/wiki/MaMF
MaMF, or Mammalian Motif Finder, is an algorithm for identifying motifs to which transcription factors bind. The algorithm takes as input a set of promoter sequences, and a motif width(w), and as output, produces a ranked list of 30 predicted motifs(each motif is defined by a set of N sequences, where N is a parameter). The algorithm firstly indexes each sub-sequence of length n, where n is a parameter around 4-6 base pairs, in each promoter, so they can be looked up efficiently. This index is then used to build a list of all pairs of sequences of length w, such that each sequence shares an n-mer, and each sequence forms an ungapped alignment with a substring of length w from the string of length 2w around the match, with a score exceeding a cut-off. The pairs of sequences are then scored. The scoring function favours pairs which are very similar, but disfavours sequences which are very common in the target genome. The 1000 highest scoring pairs are kept, and the others are discarded. Each of these 1000 'seed' motifs are then used to search iteratively search for further sequences of length which maximise the score(a greedy algorithm), until N sequences for that motif are reached. Very similar motifs are discarded, and the 30 highest scoring motifs are returned as output. References Search algorithms Bioinformatics
https://en.wikipedia.org/wiki/Lam%20Research
Lam Research Corporation is an American supplier of wafer-fabrication equipment and related services to the semiconductor industry. Its products are used primarily in front-end wafer processing, which involves the steps that create the active components of semiconductor devices (transistors, capacitors) and their wiring (interconnects). The company also builds equipment for back-end wafer-level packaging (WLP) and for related manufacturing markets such as for microelectromechanical systems (MEMS). Lam Research was founded in 1980 by David K. Lam and is headquartered in Fremont, California. As of 2018, it was the second largest manufacturer in the Bay Area, after Tesla. History Lam Research was founded in 1980 by David K. Lam, a Chinese-born engineer who had previously worked at Xerox, Hewlett-Packard, and Texas Instruments. It was while he was at Hewlett Packard that he saw the need for better plasma etching equipment, to keep up with the rapid miniaturization of semiconductor wafers. He credited Bob Noyce, founder of Intel, for assisting him in getting funding by ensuring his business plan made sense. In 1981, the company introduced its first product, the AutoEtch 480, an automated polysilicon plasma etcher. The name AutoEtch was chosen to convey that the etcher was automated, while the 80 in 480 came from 1980, the year the company was founded. The first system was sold in January 1982. In 1982, Roger Emerick was appointed CEO. In May 1984, the company issued an init
https://en.wikipedia.org/wiki/Tape-automated%20bonding
Tape-automated bonding (TAB) is a process that places bare semiconductor chips (dies) like integrated circuits onto a flexible circuit board (FPC) by attaching them to fine conductors in a polyamide or polyimide (like trade names Kapton or UPILEX) film carrier. This FPC with the die(s) (TAB inner lead bonding, ILB) can be mounted on the system or module board or assembled inside a package (TAB outer lead bonding, OLB). Typically the FPC includes from one to three conductive layers and all inputs and outputs of the semiconductor die are connected simultaneously during the TAB bonding. Tape automated bonding is one of the methods needed for achieving chip-on-flex (COF) assembly and it is one of the first roll-to-roll processing (also called R2R, reel-to-reel) type methods in the electronics manufacturing. Process The TAB mounting is done such that the bonding sites of the die, usually in the form of bumps or balls made of gold, solder or anisotropic conductive material, are connected to fine conductors on the tape, which provide the means of connecting the die to the package or directly to external circuits. The bumps or balls can locate either on the die or on the TAB tape. TAB compliant metallizations systems are: Al pads on the die < - > gold plated Cu on tape areas (thermosonic bonding) Al covered with Au on pads on the die < - > Au or Sn bumped tape areas (gang bonding) Al pads with Au bumps on the die < - > Au or Sn plated tape areas (gang bonding) Al pads wit
https://en.wikipedia.org/wiki/Reflex%20receiver
A reflex radio receiver, occasionally called a reflectional receiver, is a radio receiver design in which the same amplifier is used to amplify the high-frequency radio signal (RF) and low-frequency audio (sound) signal (AF). It was first invented in 1914 by German scientists Wilhelm Schloemilch and Otto von Bronk, and rediscovered and extended to multiple tubes in 1917 by Marius Latour and William H. Priess. The radio signal from the antenna and tuned circuit passes through an amplifier, is demodulated in a detector which extracts the audio signal from the radio carrier, and the resulting audio signal passes again through the same amplifier for audio amplification before being applied to the earphone or loudspeaker. The reason for using the amplifier for "double duty" was to reduce the number of active devices, vacuum tubes or transistors, required in the circuit, to reduce the cost. The economical reflex circuit was used in inexpensive vacuum tube radios in the 1920s, and was revived again in simple portable tube radios in the 1930s. How it works The block diagram shows the general form of a simple reflex receiver. The receiver functions as a tuned radio frequency (TRF) receiver. The radio frequency (RF) signal from the tuned circuit (bandpass filter) is amplified, then passes through the high pass filter to the demodulator, which extracts the audio frequency (AF) (modulation) signal from the carrier wave. The audio signal is added back into the input of the amplif
https://en.wikipedia.org/wiki/Human%20Protein%20Reference%20Database
The Human Protein Reference Database (HPRD) is a protein database accessible through the Internet. It is closely associated with the premier Indian Non-Profit research organisation Institute of Bioinformatics (IOB), Bangalore, India. This database is a collaborative output of IOB and the Pandey Lab of Johns Hopkins University. Overview The HPRD is a result of an international collaborative effort between the Institute of Bioinformatics in Bangalore, India and the Pandey lab at Johns Hopkins University in Baltimore, USA. HPRD contains manually curated scientific information pertaining to the biology of most human proteins. Information regarding proteins involved in human diseases is annotated and linked to Online Mendelian Inheritance in Man (OMIM) database. The National Center for Biotechnology Information provides link to HPRD through its human protein databases (e.g. Entrez Gene, RefSeq protein pertaining to genes and proteins. This resource depicts information on human protein functions including protein–protein interactions, post-translational modifications, enzyme-substrate relationships and disease associations. Protein annotation information that is catalogued was derived through manual curation using published literature by expert biologists and through bioinformatics analyses of the protein sequence. The protein–protein interaction and subcellular localization data from HPRD have been used to develop a human protein interaction network. Highlights of HPRD as fo
https://en.wikipedia.org/wiki/Antibiotic-associated%20diarrhea
Antibiotic-associated diarrhea (AAD) results from an imbalance in the colonic microbiota caused by antibiotics. Microbiotal alteration changes carbohydrate metabolism with decreased short-chain fatty acid absorption and an osmotic diarrhea as a result. Another consequence of antibiotic therapy leading to diarrhea is overgrowth of potentially pathogenic organisms such as Clostridium difficile. It is defined as frequent loose and watery stools with no other complications. Cause Clostridium difficile, also known more commonly as C. diff, accounts for 10 to 20% of antibiotic-associated diarrhea cases, because the antibiotics administered for the treatment of certain disease processes such as inflammatory colitis also inadvertently kill a large portion of the gut flora, the normal flora that is usually present within the bowel. With this lower level of "healthy" bacteria present, the overgrowth of C. diff is then responsible "for elaborating the enterotoxin". Treatment Meta-analyses have concluded that probiotics may protect against antibiotic-associated diarrhea in both children and adults. Evidence is insufficient, however, regarding an effect on rates of C. difficile colitis. Efficacy of probiotic AAD prevention is dependent on the probiotic strain(s) used and on the dosage. Up to a 50% reduction of AAD occurrences has been found. No side effects have been reported. Caution is advised when using probiotics in immunocompromised individuals or those who have a compromised int
https://en.wikipedia.org/wiki/Teco%20pottery
The American Terracotta Tile and Ceramic Company was founded in 1881; originally as Spring Valley Tile Works; in Terra Cotta, Illinois, between Crystal Lake, Illinois and McHenry, Illinois near Chicago by William Day Gates. It became the country's first manufactury of architectural terracotta in 1889. The production consisted of drain tile, brick, chimney tops, finials, urns, and other economically fireproof building materials. Gates used the facilities to experiment with clays and glazes in an effort to design a line of art pottery which led to the introduction of Teco (pronounced TĒĒ - CŌ ) Pottery. American Terra Cotta's records are housed at the University of Minnesota and include original architectural drawings. The smooth, micro-crystalline, matte "Teco Green" glaze of Teco art pottery was developed independently and wasn't an attempt to copy the famous Grueby green. Wares The pottery shapes derived from line and color rather than elaborate decoration. While most of the 500 shapes created by 1911 were the product of Gates' efforts, many of the remaining Teco designs were the work of several Chicago architects that were involved in the Prairie School style as expressed by Frank Lloyd Wright. They had rejected the revival styles of American architecture of the 19th century in favor of using wood, stone and clay in simplicity of design. Any ornamentation consisted of geometrical or natural objects which merged gracefully with the form. Teco Pottery became closely link
https://en.wikipedia.org/wiki/Nitrite%20reductase
Nitrite reductase refers to any of several classes of enzymes that catalyze the reduction of nitrite. There are two classes of NIR's. A multi haem enzyme reduces NO2− to a variety of products. Copper containing enzymes carry out a single electron transfer to produce nitric oxide. Iron based There are several types of iron based enzymes. Cytochrome cd1, or Pseudomonas cytochrome oxidase contains two c and two d type hemes with two polypeptide chains. Different forms of this reductase catalyze the formation of nitric oxide or nitrous oxide. A version of this compound was originally called [Ferrocytochrome c-551:oxidoreductase]. It was initially considered an oxidase. It catalyzes the reduction of NO2− to NO. This tetraheme enzyme has two subunits, each containing a c-type and a d-type heme. The reduced d hemes bind nitrite and convert it to product. Cytochrome c nitrite reductase (ccNIR) is a multiheme enzyme that converts nitrite to ammonia on each active site. The active site iron is bound to a protoporphyrin IX ring that is covalently linked to the enzyme's proteins. Proposed mechanism The ccNIR protein uses six electrons and seven hydrogens to reduce nitrite to ammonia. The active site of the enzyme contains an iron in a +2 oxidation state. The oxidation level allows nitrite to bond more strongly than to the +3 state due to increased pi backbonding. This electronic effect transfers electron density into the nitrite antibonding orbital between nitrogen and o
https://en.wikipedia.org/wiki/Cameleon%20%28protein%29
Cameleon is an engineered protein based on variant of green fluorescent protein used to visualize calcium levels in living cells. It is a genetically encoded calcium sensor created by Roger Y. Tsien and coworkers. The name is a conflation of CaM (the common abbreviation of calmodulin) and chameleon to indicate the fact that the sensor protein undergoes a conformation change and radiates at an altered wavelength upon calcium binding to the calmodulin element of the Cameleon. Cameleon was the first genetically encoded calcium sensor that could be used for ratiometric measurements and the first to be used in a transgenic animal to record activity in neurons and muscle cells. Cameleon and other genetically-encoded calcium indicators (GECIs) have found many applications in neuroscience and other fields of biology. It was created by fusing BFP, calmodulin, calmodulin-binding peptide M13 and EGFP. Mechanism The DNA encoding cameleon fusion protein must be either stably or transiently introduced into the cell of interest. Protein made by the cell according to this DNA information then serves as a fluorescent indicator of calcium concentration. In the presence of calcium, Ca2+ binds to M13, which enables calmodulin to wrap around the M13 domain. This brings the two GFP-variant proteins closer to each other, which increases FRET efficiency between them. References Sensors Engineered proteins Fluorescent proteins Cell imaging Calcium signaling
https://en.wikipedia.org/wiki/Comparative%20economic%20systems
Comparative Economic Systems is the sub-classification of economics dealing with the comparative study of different systems of economic organization, such as capitalism, socialism, feudalism and the mixed economy. It is widely held to have been founded by the economist Calvin Bryce Hoover. Comparative economics therefore consisted mainly of comparative economic systems analysis before 1989 but substantially switched its efforts to comparison of the economic effects of the transition experience from socialism to capitalism. It is a part of economics which is the study of gaining knowledge concerned with the production, consumption and transfer of wealth. It is based on the collective wants of the population and the resources available that initially create an economic system. The performance of the economic system can be measured through gross domestic product (GDP); that is, it will indicate the growth rate of country. Normative judgments can be made as well by asking questions like whether the gap of the distribution of wealth and income and social justice. Theoreticians regularly try to evaluate both the positive and normative aspects of the economic system in general and they do so by making assumptions about the rules of the game governing utility-seeking. It is comparatively easy to predict the economic outcomes when the economic system of the country has either a perfect competition or has a perfect planning economic system. With those types of the economic systems, it
https://en.wikipedia.org/wiki/QCM
QCM may refer to: Quality Capital Management, a UK-based hedge fund specialising in managed futures. Quartz crystal microbalance, a weighing instrument which measures a mass per unit area by measuring the change in frequency of a quartz crystal resonator Quad City Mallards, a former ECHL team that played in the Quad Cities area of Illinois Quality Control Music, an American record label
https://en.wikipedia.org/wiki/Bernstein%20inequality
In mathematics, Bernstein inequality, named after Sergei Natanovich Bernstein, may refer to: Bernstein's inequality (mathematical analysis) Bernstein inequalities (probability theory) Mathematics disambiguation pages
https://en.wikipedia.org/wiki/Chevalley%20theorem
Several theorems proved by the French mathematician Claude Chevalley bear his name. Chevalley–Shephard–Todd theorem in invariant theory of finite groups. Chevalley–Warning theorem concerning solvability of polynomial equations over finite fields. Chevalley restriction theorem identifying the invariants of the adjoint action of a semisimple algebraic group with the invariants of its Weyl group acting on the Cartan subalgebra. Chevalley's structure theorem on algebraic groups: if G is an algebraic group then it contains a unique closed normal subgroup N such that N is affine and the quotient G/N is an abelian variety. Chevalley's theorem on constructible sets.
https://en.wikipedia.org/wiki/Epinastine
Epinastine (brand names Alesion, Elestat, Purivist, Relestat) is a second-generation antihistamine and mast cell stabilizer that is used in eye drops to treat allergic conjunctivitis. It is produced by Allergan and marketed by Inspire in the United States. It is highly selective for the H1 receptor and does not cross the blood-brain-barrier. It was patented in 1980 and came into medical use in 1994. References Azepanes H1 receptor antagonists Guanidines AbbVie brands Mast cell stabilizers Peripherally selective drugs
https://en.wikipedia.org/wiki/Lyapunov%20theorem
Lyapunov theorem may refer to: Lyapunov theory, a theorem related to the stability of solutions of differential equations near a point of equilibrium Lyapunov central limit theorem, variant of the central limit theorem Lyapunov vector-measure theorem, theorem in measure theory that the range of any real-valued, non-atomic vector measure is compact and convex Lyapunov–Malkin theorem, a mathematical theorem detailing nonlinear stability of systems See also Aleksandr Lyapunov (1857-1918), Russian mathematician, mechanician and physicist Lyapunov equation, used in many branches of control theory, such as stability analysis and optimal control Lyapunov fractal, bifurcational fractals derived from an extension of the logistic map in which the degree of the growth of the population periodically switches between two values Lyapunov time, characteristic timescale on which a dynamical system is chaotic Probability theory, the branch of mathematics concerned with probability Dirichlet problem, the problem of finding a function which solves a specified partial differential equation in the interior of a given region that takes prescribed values on the boundary of the region
https://en.wikipedia.org/wiki/Profenamine
Profenamine (INN; also known as ethopropazine (BAN); solde under the trade name Parsidol and others) is a phenothiazine derivative used as an antiparkinsonian agent that has anticholinergic, antihistamine, and antiadrenergic actions. It is also used in the alleviation of the extrapyramidal syndrome induced by drugs such as other phenothiazine compounds, but, like other compounds with antimuscarinic properties, is of no value against tardive dyskinesia. Synthesis For promoting bone growth: The alkylation between phenothiazine [92-84-2] (1) and 1-Diethylamino-2-chloropropane [761-21-7] (2) in the presence of Sodium amide gives ethopropazine (3). The aziridinium salt helps to rationalize why a rearrangement product is observed (ala methadone). This was also observewd for Aceprometazine. References Alpha-1 blockers Antihistamines H1 receptor antagonists Muscarinic antagonists Phenothiazines Diethylamino compounds
https://en.wikipedia.org/wiki/Second%20Generation%20Multiplex
Second Generation Multiplex is a DNA profiling system used in the United Kingdom to set up the UK National DNA Database in 1995. It is manufactured by ABI (Applied Biosystems). It contains primers for the following STR (Short Tandem Repeat) loci. VWA (HUMVWF31/A), D8 (D8S1179), D21 (D21S11), D18 (D18S51), THO (HUMTHO1), FGA (HUMFIBRA) Also contains primers for the Amelogenin sex indicating test. The primers are tagged with the following fluorescent dyes for detection under electrophoresis. 5-FAM JOE NED Its use in the United kingdom as the DNA profiling system used by The UK National DNA Database was superseded by the Second Generation Multiplex Plus SGM+ DNA profiling system in 1998 Biometrics DNA profiling techniques Genetics in the United Kingdom Law enforcement in the United Kingdom
https://en.wikipedia.org/wiki/Protein%20Data%20Bank%20%28file%20format%29
The Protein Data Bank (PDB) file format is a textual file format describing the three-dimensional structures of molecules held in the Protein Data Bank, now succeeded by the mmCIF format. The PDB format accordingly provides for description and annotation of protein and nucleic acid structures including atomic coordinates, secondary structure assignments, as well as atomic connectivity. In addition experimental metadata are stored. The PDB format is the legacy file format for the Protein Data Bank which now keeps data on biological macromolecules in the newer mmCIF file format. History The PDB file format was invented in 1976 as a human-readable file that would allow researchers to exchange protein coordinates through a database system. Its fixed-column width format is limited to 80 columns, which was based on the width of the computer punch cards that were previously used to exchange the coordinates. Through the years the file format has undergone many changes and revisions. , the most recent revision is 3.30. Example A typical PDB file describing a protein consists of hundreds to thousands of lines like the following (taken from a file describing the structure of a synthetic collagen-like peptide): HEADER EXTRACELLULAR MATRIX 22-JAN-98 1A3I TITLE X-RAY CRYSTALLOGRAPHIC DETERMINATION OF A COLLAGEN-LIKE TITLE 2 PEPTIDE WITH THE REPEATING SEQUENCE (PRO-PRO-GLY) ... EXPDTA X-RAY DIFFRACTION AUTHOR R.Z.KRAMER,L.VITAGLIANO,J.BELLA,R.BERISIO,
https://en.wikipedia.org/wiki/Second%20Generation%20Multiplex%20Plus
Second Generation Multiplex Plus (SGM Plus), is a DNA profiling system developed by Applied Biosystems. It is an updated version of Second Generation Multiplex. SGM Plus has been used by the UK National DNA Database since 1998. An SGM Plus profile consists of a list of 10 number pairs, one number pair for each of 10 genetic markers, along with two letters (XX or XY) which show the result of the Amelogenin sex indicating test. Each number pair denotes the two allele values for the marker - one value is inherited from each of the subject's parents. If both alleles are the same, then only a single number, rather than a pair, is recorded. Genetic markers The genetic markers (or loci) used by SGM Plus are all short tandem repeats (STRs). The markers used are: VWA, D8S1179, D21S11, D18S51, TH01, FGA, D3S1358, D16S539, D2S1338 and D19S433. Where a marker's designation begins with D, the digits immediately following the D indicate the chromosome that contains the marker. For example, D21S11 is on chromosome 21. SGM Plus also uses the amelogenin (amelo) sex-indicating test. SGM Plus differs from SGM in that SGM does not use the markers D3S1358, D16S539, D2S1338 and D19S433. SGM Plus has eight markers in common with CODIS FGA, TH01, VWA, D3S1358, D8S1179, D16S539, D18S51, and D21S11. It differs from CODIS in that it uses the additional markers D2S1338 and D19S433 and does not use the five markers CSF1PO, TPOX, D5S818, D7S820, D13S317. Dye tags The primers are tagged with the foll
https://en.wikipedia.org/wiki/Clavipectoral%20fascia
The clavipectoral fascia (costocoracoid membrane; coracoclavicular fascia) is a strong fascia situated under cover of the clavicular portion of the pectoralis major. It occupies the interval between the pectoralis minor and subclavius, and protects the axillary vein and artery, and axillary nerve. Traced upward, it splits to enclose the subclavius, and its two layers are attached to the clavicle, one in front of and the other behind the muscle; the deep layer fuses with the deep cervical fascia and with the sheath of the axillary vessels. Medially, it blends with the fascia covering the first two intercostal spaces, and is attached also to the first rib medial to the origin of the subclavius. Laterally, it is very thick and dense, and is attached to the coracoid process. The portion extending from the first rib to the coracoid process is often whiter and denser than the rest, and is sometimes called the costocoracoid membrane. Below this it is thin, and at the upper border of the pectoralis minor it splits into two layers to invest the muscle; from the lower border of the pectoralis minor it is continued downward to join the axillary fascia, and lateralward to join the fascia over the short head of the biceps brachii. The clavipectoral fascia is pierced by the cephalic vein, thoracoacromial artery and vein, lymphatics and lateral pectoral nerve. See also Suspensory ligament of axilla References External links - "Pectoral Region: Reflect Pectoralis Major Muscle"
https://en.wikipedia.org/wiki/Wolfram%20code
Wolfram code is a widely used numbering system for one-dimensional cellular automaton rules, introduced by Stephen Wolfram in a 1983 paper and popularized in his book A New Kind of Science. The code is based on the observation that a table specifying the new state of each cell in the automaton, as a function of the states in its neighborhood, may be interpreted as a k-digit number in the S-ary positional number system, where S is the number of states that each cell in the automaton may have, k = S2n + 1 is the number of neighborhood configurations, and n is the radius of the neighborhood. Thus, the Wolfram code for a particular rule is a number in the range from 0 to SS − 1, converted from S-ary to decimal notation. It may be calculated as follows: List all the S2n + 1 possible state configurations of the neighbourhood of a given cell. Interpreting each configuration as a number as described above, sort them in descending numerical order. For each configuration, list the state which the given cell will have, according to this rule, on the next iteration. Interpret the resulting list of states again as an S-ary number, and convert this number to decimal. The resulting decimal number is the Wolfram code. The Wolfram code does not specify the size (nor shape) of the neighbourhood, nor the number of states — these are assumed to be known from context. When used on their own without such context, the codes are often assumed to refer to the class of elementary cellular aut
https://en.wikipedia.org/wiki/Ludvig%20Faddeev
Ludvig Dmitrievich Faddeev (also Ludwig Dmitriyevich; ; 23 March 1934 – 26 February 2017) was a Soviet and Russian mathematical physicist. He is known for the discovery of the Faddeev equations in the theory of the quantum mechanical three-body problem and for the development of path integral methods in the quantization of non-abelian gauge field theories, including the introduction (with Victor Popov) of Faddeev–Popov ghosts. He led the Leningrad School, in which he along with many of his students developed the quantum inverse scattering method for studying quantum integrable systems in one space and one time dimension. This work led to the invention of quantum groups by Drinfeld and Jimbo. Biography Faddeev was born in Leningrad to a family of mathematicians. His father, Dmitry Faddeev, was a well known algebraist, professor of Leningrad University and member of the Russian Academy of Sciences. His mother, Vera Faddeeva, was known for her work in numerical linear algebra. Faddeev attended Leningrad University, receiving his undergraduate degree in 1956. He enrolled in physics, rather than mathematics, "to be independent of [his] father". Nevertheless, he received a solid education in mathematics as well "due to the influence of V. A. Fock and V. I. Smirnov". His doctoral work, on scattering theory, was completed in 1959 under the direction of Olga Ladyzhenskaya. From 1976 to 2000, Faddeev was head of the St. Petersburg Department of Steklov Institute of Mathematic
https://en.wikipedia.org/wiki/Cerv%C3%A9lo
Cervélo Cycles is a Canadian manufacturer of racing and track bicycles. Cervélo uses CAD, computational fluid dynamics, and wind tunnel testing at a variety of facilities including the San Diego Air and Space Technology Center, in California, US, to aid its designs. Frame materials include carbon fibre. Cervélo currently makes 5 series of bikes: the C series and R series of road bikes, the latter featuring multi-shaped, "Squoval" frame tubes; the S series of road bikes and P series of triathlon/time trial bikes, both of which feature airfoil shaped down tubes; and the T series of track bikes. In professional competition, cyclists have ridden Cervélo bicycles to victory in all three of road cycling's grand tours: the Tour de France; the Giro d'Italia; and the Vuelta a España. History Gerard Vroomen, one of the two founders of the company, started researching bike dynamics at the Eindhoven University of Technology. He took his knowledge to Canada to continue the research in McGill University. In 1995, Vroomen and Phil White founded Cervélo Cycles. The name Cervélo is a portmanteau of cervello, the Italian word for brain, and vélo, the French word for bike. In May 2011, Vroomen sold his stake in Cervélo to pursue new projects, although he is nominally still involved with the company at the board level. Cervélo is now owned by Pon Holdings, a Dutch company that also owns Gazelle, and Derby Cycle. The company makes or has marketing rights to bicycles from Raleigh, Kalkhoff, U
https://en.wikipedia.org/wiki/Moral%20graph
In graph theory, a moral graph is used to find the equivalent undirected form of a directed acyclic graph. It is a key step of the junction tree algorithm, used in belief propagation on graphical models. The moralized counterpart of a directed acyclic graph is formed by adding edges between all pairs of non-adjacent nodes that have a common child, and then making all edges in the graph undirected. Equivalently, a moral graph of a directed acyclic graph is an undirected graph in which each node of the original is now connected to its Markov blanket. The name stems from the fact that, in a moral graph, two nodes that have a common child are required to be married by sharing an edge. Moralization may also be applied to mixed graphs, called in this context "chain graphs". In a chain graph, a connected component of the undirected subgraph is called a chain. Moralization adds an undirected edge between any two vertices that both have outgoing edges to the same chain, and then forgets the orientation of the directed edges of the graph. Weakly recursively simplicial A graph is weakly recursively simplicial if it has a simplicial vertex and the subgraph after removing a simplicial vertex and some edges (possibly none) between its neighbours is weakly recursively simplicial. A graph is moral if and only if it is weakly recursively simplicial. A chordal graph (a.k.a., recursive simplicial) is a special case of weakly recursively simplicial when no edge is removed during the elimi
https://en.wikipedia.org/wiki/Junction%20tree%20algorithm
The junction tree algorithm (also known as 'Clique Tree') is a method used in machine learning to extract marginalization in general graphs. In essence, it entails performing belief propagation on a modified graph called a junction tree. The graph is called a tree because it branches into different sections of data; nodes of variables are the branches. The basic premise is to eliminate cycles by clustering them into single nodes. Multiple extensive classes of queries can be compiled at the same time into larger structures of data. There are different algorithms to meet specific needs and for what needs to be calculated. Inference algorithms gather new developments in the data and calculate it based on the new information provided. Junction tree algorithm Hugin algorithm If the graph is directed then moralize it to make it un-directed. Introduce the evidence. Triangulate the graph to make it chordal. Construct a junction tree from the triangulated graph (we will call the vertices of the junction tree "supernodes"). Propagate the probabilities along the junction tree (via belief propagation) Note that this last step is inefficient for graphs of large treewidth. Computing the messages to pass between supernodes involves doing exact marginalization over the variables in both supernodes. Performing this algorithm for a graph with treewidth k will thus have at least one computation which takes time exponential in k. It is a message passing algorithm. The Hugin algorithm take
https://en.wikipedia.org/wiki/Sexual%20Sterilization%20Act
In 1928, the Legislative Assembly of Alberta, Canada, enacted the Sexual Sterilization Act. The Act, drafted to protect the gene pool, allowed for sterilization of mentally disabled people in order to prevent the transmission of traits to offspring deemed undesirable. At that time, eugenicists argued that mental illness, mental retardation, epilepsy, alcoholism, pauperism, certain criminal behaviours, and social defects, such as prostitution and sexual perversion, were genetically determined and inherited. Further, it was widely believed that persons with these disorders had a higher reproduction rate than the normal population. As a result, it was feared the gene pool in the general population was weakening. During the time the Sexual Sterilization Act was in effect, 4,800 cases were proposed for sterilization in the Province of Alberta, of which 99% received approval. Examination of sterilization records demonstrates that legislation did not apply equally to all members of society. Specifically, the Act was disproportionately applied to those in socially vulnerable positions, including females, children, unemployed persons, domestic servants, rural citizens, unmarried, institutionalized persons, Roman and Greek Catholics, and persons of Ukrainian, Native and Métis ethnicity. The Act was repealed in 1972. Enactment The Sexual Sterilization Act was first introduced into the legislature on March 5, 1927, but due to a crowded session and unclear bill format, it was pulle
https://en.wikipedia.org/wiki/Single-equation%20methods%20%28econometrics%29
A variety of methods are used in econometrics to estimate models consisting of a single equation. The oldest and still the most commonly used is the ordinary least squares method used to estimate linear regressions. A variety of methods are available to estimate non-linear models. A particularly important class of non-linear models are those used to estimate relationships where the dependent variable is discrete, truncated or censored. These include logit, probit and Tobit models. Single equation methods may be applied to time-series, cross section or panel data. External links Mathematical and quantitative methods (economics)
https://en.wikipedia.org/wiki/Drag%20area
In mechanics and aerodynamics, the drag area of an object represents the effective size of the object as it is "seen" by the fluid flow around it. The drag area is usually expressed as a product where is a representative area of the object, and is the drag coefficient, which represents what shape it has and how streamlined it is. The drag coefficient plays a role in Reynold's drag equation, Here, is the drag force, the density of the fluid, and the speed of the object relative to the fluid. See also Drag (physics) Automobile drag coefficient#Drag area Zero-lift drag coefficient Drag (physics)
https://en.wikipedia.org/wiki/Turbo%20%28finance%29
A turbo is a leveraged financial derivative first introduced by Goldman Sachs in 2004. They are tradable by institutional and private investors and have characteristics similar to contracts for difference and covered warrants. Turbo's are popular in Germany and the Netherlands. Characteristics The most important characteristic of a turbo is the strict connection of its value to the price of the underlying asset, which is generally a stock or an index. The value of the underlying stock is multiplied by the leverage value to give the value of the turbo. Unlike other financial derivatives, the leverage of a turbo is kept constant on a daily basis. However the issuer can change the leverage by a predetermined fixed procedure. The rationale of a rolling turbo arises from a combination of a predictable course process of the base value stock and the promise of a proportionally higher profit than would be possible with the purchase of the base stock. Rolling turbos also offer the possibility of speculating on falling quotations. On the DAX rolling turbos with leverages between 5 and 35 are offered. Comparison to other derivatives Its lifetime is usually not time-limited. Unlike financial derivatives that are forced to terminate after severe exchange rate fluctuations, the risk of a catastrophic loss is smaller. German regulations In Germany the profit that private investors make from a rolling turbo is subject to tax. The investor must also comply with the German § 37d secu
https://en.wikipedia.org/wiki/Vanoxerine
Vanoxerine is a piperazine derivative which is a potent and selective dopamine reuptake inhibitor (DRI). Vanoxerine binds to the target site on the dopamine transporter (DAT) ~ 50 times more strongly than cocaine, but simultaneously inhibits the release of dopamine. This combined effect only slightly elevates dopamine levels, giving vanoxerine only mild stimulant effects. Vanoxerine has also been observed to be a potent blocker of the IKr (hERG) channel. Vanoxerine also binds with nanomolar affinity to the serotonin transporter. Vanoxerine as a treatment for cocaine dependence Vanoxerine has been researched for use in treating cocaine dependence both as a substitute for cocaine and to block the rewarding effects. This strategy of using a competing agonist with a longer half-life has been successfully used to treat addiction to opiates such as heroin by substituting with methadone. It was hoped that vanoxerine would be of similar use in treating cocaine addiction. Research also indicates that vanoxerine may have additional mechanisms of action including antagonist action at nicotinic acetylcholine receptors, and it has also been shown to reduce the consumption of alcohol in animal models of alcohol use disorder. Vanoxerine has been through human trials up to Phase II, but development was stopped due to observed QTc effects in the context of cocaine use. However, vanoxerine analogs continue to be studied as treatments for cocaine addiction. As an example, GBR compounds a
https://en.wikipedia.org/wiki/Durbin%E2%80%93Watson%20statistic
In statistics, the Durbin–Watson statistic is a test statistic used to detect the presence of autocorrelation at lag 1 in the residuals (prediction errors) from a regression analysis. It is named after James Durbin and Geoffrey Watson. The small sample distribution of this ratio was derived by John von Neumann (von Neumann, 1941). Durbin and Watson (1950, 1951) applied this statistic to the residuals from least squares regressions, and developed bounds tests for the null hypothesis that the errors are serially uncorrelated against the alternative that they follow a first order autoregressive process. Note that the distribution of this test statistic does not depend on the estimated regression coefficients and the variance of the errors. A similar assessment can be also carried out with the Breusch–Godfrey test and the Ljung–Box test. Computing and interpreting the Durbin–Watson statistic If is the residual given by the Durbin-Watson test statistic is where is the number of observations. For large , is approximately equal to , where is the sample autocorrelation of the residuals. therefore indicates no autocorrelation. The value of always lies between and . If the Durbin–Watson statistic is substantially less than 2, there is evidence of positive serial correlation. As a rough rule of thumb, if Durbin–Watson is less than 1.0, there may be cause for alarm. Small values of indicate successive error terms are positively correlated. If , successive error terms are
https://en.wikipedia.org/wiki/Superior%20labial%20nerve
The superior labial branches (labial branches), the largest and most numerous, descend behind the quadratus labii superioris, and are distributed to the skin of the upper lip, the mucous membrane of the mouth, and labial glands. They are joined, immediately beneath the orbit, by filaments from the facial nerve, forming with them the infraorbital plexus. See also Superior labial artery External links Maxillary nerve
https://en.wikipedia.org/wiki/Trigeminal%20cave
The trigeminal cave (also known as Meckel's cave or cavum trigeminale) is a pouch of dura mater containing cerebrospinal fluid. Structure The trigeminal cave is formed by the two layers of dura mater (endosteal and meningeal) which are part of an evagination of the cerebellar tentorium near the apex of the petrous part of the temporal bone. It envelops the trigeminal ganglion. It is bounded by the dura overlying four structures: cerebellar tentorium superolaterally lateral wall of the cavernous sinus superomedially clivus medially posterior petrous face inferolaterally Within the dural confines of the trigeminal cave, there is a continuation of subarachnoid space along the posterior aspect of the cave, representing a continuation of the cerebral basal cisterns. History Etymology It is named for Johann Friedrich Meckel, the Elder. References Meninges
https://en.wikipedia.org/wiki/Infraorbital%20plexus
The superior labial branches descend behind the Quadratus labii superioris, and are distributed to the skin of the upper lip, the mucous membrane of the mouth, and labial glands. They are joined, immediately beneath the orbit, by filaments from the facial nerve, forming with them the infraorbital plexus. External links Nerve plexus Maxillary nerve
https://en.wikipedia.org/wiki/List%20of%20Sheffield%20Wednesday%20F.C.%20players
This is a list of footballers who have played for Sheffield Wednesday F.C. in competitive fixtures. Appearance and goal statistics are for all competitions. For current players see Current squad. References Sheffield Wednesday Players Association football player non-biographical articles
https://en.wikipedia.org/wiki/Spin%20chemistry
Spin chemistry is a sub-field of chemistry positioned at the intersection of chemical kinetics, photochemistry, magnetic resonance and free radical chemistry, that deals with magnetic and spin effects in chemical reactions. Spin chemistry concerns phenomena such as chemically induced dynamic nuclear polarization (CIDNP), chemically induced electron polarization (CIDEP), magnetic isotope effects in chemical reactions, and it is hypothesized to be key in the underlying mechanism for avian magnetoreception and consciousness. Radical-pair mechanism The radical-pair mechanism explains how a magnetic field can affect reaction kinetics by affecting electron spin dynamics. Most commonly demonstrated in reactions of organic compounds involving radical intermediates, a magnetic field can speed up a reaction by decreasing the frequency of reverse reactions. History The radical-pair mechanism emerged as an explanation to CIDNP and CIDEP and was proposed in 1969 by Closs; Kaptein and Oosterhoff. Radicals and radical-pairs A radical is a molecule with an odd number of electrons, and is induced in a variety of ways, including ultra-violet radiation. A sun burn is largely due to radical formation from this radiation. The radical-pair, however, is not simply two radicals. This is because radical-pairs (specifically singlets) are quantum entangled, even as separate molecules. More fundamental to the radical-pair mechanism, however, is the fact that radical-pair electrons both have spi
https://en.wikipedia.org/wiki/NSMB%20%28mathematics%29
NSMB is a computer system for solving Navier–Stokes equations using the finite volume method. It supports meshes built of several blocks (multi-blocks) and supports parallelisation. The name stands for "Navier–Stokes multi-block". It was developed by a consortium of European scientific institutions and companies, between 1992 and 2003. References Numerical software
https://en.wikipedia.org/wiki/Martin%20Smith%20%28academic%29
Martin Smith is a former Professor of Robotics at Middlesex University in north London, UK. He is also a former President of the Cybernetics Society in the UK (1999 - 2020). Smith was awarded Freedom of the City of London, and was awarded the Public Awareness of Physics Award by the Institute of Physics. Television appearances Smith has appeared on many television programmes: as a technical presenter on the BBC television programme Techno Games and as a judge on Robot Wars from the third series having previously competed in the first series. He was a judge and programme consultant on Channel 4's Scrapheap Challenge and technical presenter on Granada TV's Mutant Machines. He has also appeared on Tomorrow's World, Tomorrow's World Live at the NEC, and the Royal Institution Christmas Lectures series entitled The Rise of Robots. Editorships Smith is a member of the editorial boards of Kybernetes: The International Journal of Cybernetics and Systems, The International Journal of Advanced Robotic Systems, The International Journal of Applied Systemic Studies, the International Journal of General Systems, and The International Journal of Social Robotics. He is a Director of the World Organisation of Systems and Cybernetics. Former posts He has held posts as Visiting Research Professor in Robotics at the Open University, Professor at the University of Central England UK, (now Birmingham City University) and at the University of East London (UK) where he was founder and Head
https://en.wikipedia.org/wiki/Executive%20car
Executive car is a British term for a large car which is equivalent to the European E-segment and American full-size classifications. Executive cars are larger than compact executive cars (and the non-luxury equivalent mid-size cars), and smaller than luxury saloons / full-size luxury sedans. The term has also been adopted by Euro NCAP, a European organization founded to test for car safety. Background The term was coined in the 1960s to describe cars targeted at successful professionals and middle-to-senior managers. It was used by businesses as an incentive for employees in senior roles and to exploit Britain and Europe's tax schemes as a company owned vehicle. Early executive cars typically offered engines with displacements of , compared with for an equivalent sized—but less luxurious—"large family car". Prior to the 1990s, executive cars were typically sedans, however in recent years they have also been produced in other body styles, such as estates (station wagons), convertibles, coupés, and five-door hatch versions. They typically need to be "comfortable, refined and display some form of driving pleasure" on occasion. Body styles In general, executive cars are 4-door saloons, though may include estate, 5-door hatchback or 2-door coupé variants. Rover, Saab, Renault and Citroën formerly have been known to prefer variants to sedans, with Ford also offering alternatives through the 1990s. Audi, BMW and later Mercedes-AMG have recently offered such body styles as op
https://en.wikipedia.org/wiki/Co-occurrence
In linguistics, co-occurrence or cooccurrence is an above-chance frequency of ordered occurrence of two adjacent terms in a text corpus. Co-occurrence in this linguistic sense can be interpreted as an indicator of semantic proximity or an idiomatic expression. Corpus linguistics and its statistic analyses reveal patterns of co-occurrences within a language and enable to work out typical collocations for its lexical items. A co-occurrence restriction is identified when linguistic elements never occur together. Analysis of these restrictions can lead to discoveries about the structure and development of a language. Co-occurrence can be seen an extension of word counting in higher dimensions. Co-occurrence can be quantitatively described using measures like correlation or mutual information. See also Distributional hypothesis Statistical semantics Idiom (language structure) Co-occurrence matrix Co-occurrence networks Similarity measure Dice coefficient References External links Corpus linguistics
https://en.wikipedia.org/wiki/Flow%20separation
In fluid dynamics, flow separation or boundary layer separation is the detachment of a boundary layer from a surface into a wake. A boundary layer exists whenever there is relative movement between a fluid and a solid surface with viscous forces present in the layer of fluid close to the surface. The flow can be externally, around a body, or internally, in an enclosed passage. Boundary layers can be either laminar or turbulent. A reasonable assessment of whether the boundary layer will be laminar or turbulent can be made by calculating the Reynolds number of the local flow conditions. Separation occurs in flow that is slowing down, with pressure increasing, after passing the thickest part of a streamline body or passing through a widening passage, for example. Flowing against an increasing pressure is known as flowing in an adverse pressure gradient. The boundary layer separates when it has travelled far enough in an adverse pressure gradient that the speed of the boundary layer relative to the surface has stopped and reversed direction. The flow becomes detached from the surface, and instead takes the forms of eddies and vortices. The fluid exerts a constant pressure on the surface once it has separated instead of a continually increasing pressure if still attached. In aerodynamics, flow separation results in reduced lift and increased pressure drag, caused by the pressure differential between the front and rear surfaces of the object. It causes buffeting of aircraft st
https://en.wikipedia.org/wiki/Polycide
Polycide is a silicide formed over polysilicon. Widely used in DRAMs. In a polycide MOSFET transistor process, the silicide is formed only over the polysilicon film as formation occurs prior to any polysilicon etch. Polycide processes contrast with salicide processes in which silicide is formed after the polysilicon etch. Thus, with a salicide process, silicide is formed over both the polysilicon gate and the exposed monocrystalline terminal regions of the transistor in a self-aligned fashion. Semiconductor device fabrication Silicon
https://en.wikipedia.org/wiki/Acid%20phosphatase
Acid phosphatase (EC 3.1.3.2, systematic name phosphate-monoester phosphohydrolase (acid optimum)) is an enzyme that frees attached phosphoryl groups from other molecules during digestion. It can be further classified as a phosphomonoesterase. It is stored in lysosomes and functions when these fuse with endosomes, which are acidified while they function; therefore, it has an acid pH optimum. This enzyme is present in many animal and plant species. Different forms of acid phosphatase are found in different organs, and their serum levels are used to evaluate the success of the surgical treatment of prostate cancer. In the past, they were also used to diagnose this type of cancer. It's also used as a cytogenetic marker to distinguish the two different lineages of acute lymphoblastic leukemia (ALL) : B-ALL (a leukemia of B lymphocytes) is acid-phosphatase negative , T-ALL (originating instead from T Lymphocytes) is acid-phosphatase positive . Acid phosphatase catalyzes the following reaction at an optimal acidic pH (below 7): a phosphate monoester + H2O = an alcohol + phosphate Phosphatase enzymes are also used by soil microorganisms to access organically bound phosphate nutrients. An assay on the rates of activity of these enzymes may be used to ascertain biological demand for phosphates in the soil. Some plant roots, especially cluster roots, exude carboxylates that perform acid phosphatase activity, helping to mobilise phosphorus in nutrient-deficient soils. Certain b
https://en.wikipedia.org/wiki/Law%20of%20the%20wall
In fluid dynamics, the law of the wall (also known as the logarithmic law of the wall) states that the average velocity of a turbulent flow at a certain point is proportional to the logarithm of the distance from that point to the "wall", or the boundary of the fluid region. This law of the wall was first published in 1930 by Hungarian-American mathematician, aerospace engineer, and physicist Theodore von Kármán. It is only technically applicable to parts of the flow that are close to the wall (<20% of the height of the flow), though it is a good approximation for the entire velocity profile of natural streams. General logarithmic formulation The logarithmic law of the wall is a self similar solution for the mean velocity parallel to the wall, and is valid for flows at high Reynolds numbers — in an overlap region with approximately constant shear stress and far enough from the wall for (direct) viscous effects to be negligible: with and where {| border="0" |- ||| is the wall coordinate: the distance y to the wall, made dimensionless with the friction velocity uτ and kinematic viscosity ν, |- ||| is the dimensionless velocity: the velocity u parallel to the wall as a function of y (distance from the wall), divided by the friction velocity uτ, |- ||| is the wall shear stress, |- ||| is the fluid density, |- ||| is called the friction velocity or shear velocity, |- ||| is the Von Kármán constant, |- ||| is a constant, and |- ||| is the natural logarithm. |} From exp
https://en.wikipedia.org/wiki/Ishar
Ishar is a series of three role-playing video games by Silmarils for IBM PC compatibles, Amiga, Atari ST, and Macintosh. They are preceded by Crystals of Arborea. The games are played in first-person perspective, with all but Crystals of Arborea allowing the player to direct a group of five characters, each with a selectable race, gender, and class. Crystals of Arborea Crystals of Arborea was published by Silmarils in 1991. It precedes Ishar both chronologically and by its gameplay. Morgoth, the main antagonist of Crystals of Arborea, is the father of Krogh, the one of Ishar: Legend of the Fortress. Moreover, most of the heroes of the game, Jarel's companions, can be met in Ishar or even in Ishar 2. Ishar: Legend of the Fortress The first game in the series came out in 1992 on Amiga, Atari ST and DOS. It takes place on the island of Kendoria. At the beginning, the player controls a warrior called Aramir, and he must defeat Krogh, an evil sorcerer who has killed lord Jarel. The game takes its name from Krogh's fortress, Ishar, whose name means "unknown" in the game's fictional elf language. In order to achieve this, the player's characters must travel across the whole island and, among other things, meet with the surviving companions of Jarel. Ishar 2: Messengers of Doom Ishar 2 was published in 1993 on Amiga, Atari ST and DOS. In Ishar 2, the player starts with the character of Zubaran, who is the new lord of Ishar. He receives a vision that tells him to defeat the s
https://en.wikipedia.org/wiki/Thismiaceae
Thismiaceae is a family of flowering plants whose status is currently uncertain. The Angiosperm Phylogeny Group classifications (APG II, APG III , and APG IV) merge Thismiaceae into Burmanniaceae, noting that some studies have suggested that Thismiaceae, Burmanniaceae and Taccaceae should be separate families, whereas others support their merger. The family has been recognized by some authors (like J. Hutchinson, Chase et al. 1995, 2000; Caddick et al. 2000; Neyland 2002; Thiele & Jordan 2002, Merckx et al. 2006 and Woodward et al. 2007). Others have supported the APG position of merging the family into Burmanniaceae, sometimes as the tribe Thismieae (Maas-van de Kamer in Kubitzki system and others). For those who keep the family separate, it consists of five genera, three (Afrothismia, Haplothismia and Oxygyne) are entirely from Old World, Thismia is from tropical areas of both America and Asia, as well as three temperate species in Illinois (U.S.A), Japan and New Zealand, temperate Australia and Tiputinia is from the Amazon basin. List of genera Afrothismia (Engl.) Schltr. Haplothismia Airy Shaw Oxygyne Schltr. Thismia Griff. Tiputinia P.E. Berry & C. L. Woodw. References External links Thismiaceae in L. Watson and M.J. Dallwitz (1992 onwards). The families of flowering plants: descriptions, illustrations, identification, information retrieval. Thismiaceae in Neotropikey, key and other information resources for flowering plants of the Neotropics from Kew Diosco
https://en.wikipedia.org/wiki/Stepwise%20regression
In statistics, stepwise regression is a method of fitting regression models in which the choice of predictive variables is carried out by an automatic procedure. In each step, a variable is considered for addition to or subtraction from the set of explanatory variables based on some prespecified criterion. Usually, this takes the form of a forward, backward, or combined sequence of F-tests or t-tests. The frequent practice of fitting the final selected model followed by reporting estimates and confidence intervals without adjusting them to take the model building process into account has led to calls to stop using stepwise model building altogether or to at least make sure model uncertainty is correctly reflected. Alternatives include other model selection techniques, such as adjusted R2, Akaike information criterion, Bayesian information criterion, Mallows's Cp, PRESS, or false discovery rate. Main approaches The main approaches for stepwise regression are: Forward selection, which involves starting with no variables in the model, testing the addition of each variable using a chosen model fit criterion, adding the variable (if any) whose inclusion gives the most statistically significant improvement of the fit, and repeating this process until none improves the model to a statistically significant extent. Backward elimination, which involves starting with all candidate variables, testing the deletion of each variable using a chosen model fit criterion, deleting the va
https://en.wikipedia.org/wiki/Gabor%20transform
The Gabor transform, named after Dennis Gabor, is a special case of the short-time Fourier transform. It is used to determine the sinusoidal frequency and phase content of local sections of a signal as it changes over time. The function to be transformed is first multiplied by a Gaussian function, which can be regarded as a window function, and the resulting function is then transformed with a Fourier transform to derive the time-frequency analysis. The window function means that the signal near the time being analyzed will have higher weight. The Gabor transform of a signal x(t) is defined by this formula: The Gaussian function has infinite range and it is impractical for implementation. However, a level of significance can be chosen (for instance 0.00001) for the distribution of the Gaussian function. Outside these limits of integration () the Gaussian function is small enough to be ignored. Thus the Gabor transform can be satisfactorily approximated as This simplification makes the Gabor transform practical and realizable. The window function width can also be varied to optimize the time-frequency resolution tradeoff for a particular application by replacing the with for some chosen . Inverse Gabor transform The Gabor transform is invertible. Because it is over-complete, the original signal can be recovered in a variety of ways. For example, the "unwindowing" approach can be used for any : Alternatively, all of the time components can be combined together: Pro
https://en.wikipedia.org/wiki/Brynmor%20Jones%20Library
The Brynmor Jones Library (BJL) is the main library at the University of Hull, England. In 1967 it was named after Sir Brynmor Jones (1903-1989) who initiated research in the field of Liquid Crystals (LCD) at Hull and became Head of the Department of Chemistry in 1947. He was the Vice-Chancellor of the University from 1956 to 1972. The building consists of two main sections, the older Art Deco style entrance and front section, built in the 1950s, which is five floors high (originally three which were later subdivided by mezzanines) and the newer extension, completed in 1970, which consists of eight floors plus a basement. The older section has two exterior bas-relief sculptures by Willi Soukop, one is of an owl, the other shows a human figure representing the light of knowledge and is positioned directly over the main entrance. The new section has views over the Humber with three lifts for student use and a fourth lift for staff. It contains over a million books, plus other reference materials, mainly for use by students at the university. There are also a large number of open access computers within the library which are connected to the University network. The poet Philip Larkin served as Librarian here for thirty years from 1955 until his death in 1985. The library serves as home to the university's Art Collection, started in 1963 the collection's focus is British art from 1890 to 1940, including works by the Bloomsbury and Camden Town Groups. References External lin
https://en.wikipedia.org/wiki/Algorithmic%20art
Algorithmic art or algorithm art is art, mostly visual art, in which the design is generated by an algorithm. Algorithmic artists are sometimes called algorists. Overview Algorithmic art, also known as computer-generated art, is a subset of generative art (generated by an autonomous system) and is related to systems art (influenced by systems theory). Fractal art is an example of algorithmic art. For an image of reasonable size, even the simplest algorithms require too much calculation for manual execution to be practical, and they are thus executed on either a single computer or on a cluster of computers. The final output is typically displayed on a computer monitor, printed with a raster-type printer, or drawn using a plotter. Variability can be introduced by using pseudo-random numbers. There is no consensus as to whether the product of an algorithm that operates on an existing image (or on any input other than pseudo-random numbers) can still be considered computer-generated art, as opposed to computer-assisted art. History Roman Verostko argues that Islamic geometric patterns are constructed using algorithms, as are Italian Renaissance paintings which make use of mathematical techniques, in particular linear perspective and proportion. Some of the earliest known examples of computer-generated algorithmic art were created by Georg Nees, Frieder Nake, A. Michael Noll, Manfred Mohr and Vera Molnár in the early 1960s. These artworks were executed by a plotter contro
https://en.wikipedia.org/wiki/DISCUS
DISCUS, or distributed source coding using syndromes, is a method for distributed source coding. It is a compression algorithm used to compress correlated data sources. The method is designed to achieve the Slepian–Wolf bound by using channel codes. History DISCUS was invented by researchers S. S. Pradhan and K. Ramachandran, and first published in their paper "Distributed source coding using syndromes (DISCUS): design and construction", published in the IEEE Transactions on Information Theory in 2003. Variations Many variations of DISCUS are presented in related literature. One such popular scheme is the Channel Code Partitioning scheme, which is an a-priori scheme, to reach the Slepian–Wolf bound. Many papers illustrate simulations and experiments on channel code partitioning using the turbo codes, Hamming codes and irregular repeat-accumulate codes. See also Modulo-N code is a simpler technique for compressing correlated data sources. Distributed source coding External links "Distributed source coding using syndromes (DISCUS): design and construction" by Pradhan, S.S. and Ramchandran, K. "DISCUS: Distributed Compression for Sensor Networks" Distributed Source Coding can also be implemented using Convolutional Codes or using Turbo Codes Information theory Wireless sensor network
https://en.wikipedia.org/wiki/Nullcline
In mathematical analysis, nullclines, sometimes called zero-growth isoclines, are encountered in a system of ordinary differential equations where here represents a derivative of with respect to another parameter, such as time . The 'th nullcline is the geometric shape for which . The equilibrium points of the system are located where all of the nullclines intersect. In a two-dimensional linear system, the nullclines can be represented by two lines on a two-dimensional plot; in a general two-dimensional system they are arbitrary curves. History The definition, though with the name ’directivity curve’, was used in a 1967 article by Endre Simonyi. This article also defined 'directivity vector' as , where P and Q are the dx/dt and dy/dt differential equations, and i and j are the x and y direction unit vectors. Simonyi developed a new stability test method from these new definitions, and with it he studied differential equations. This method, beyond the usual stability examinations, provided semi-quantitative results. References Notes E. Simonyi – M. Kaszás: Method for the Dynamic Analysis of Nonlinear Systems, Periodica Polytechnica Chemical Engineering – Chemisches Ingenieurwesen, Polytechnical University Budapest, 1969 External links SOS Mathematics: Qualitative Analysis Differential equations
https://en.wikipedia.org/wiki/Parks%E2%80%93McClellan%20filter%20design%20algorithm
The Parks–McClellan algorithm, published by James McClellan and Thomas Parks in 1972, is an iterative algorithm for finding the optimal Chebyshev finite impulse response (FIR) filter. The Parks–McClellan algorithm is utilized to design and implement efficient and optimal FIR filters. It uses an indirect method for finding the optimal filter coefficients. The goal of the algorithm is to minimize the error in the pass and stop bands by utilizing the Chebyshev approximation. The Parks–McClellan algorithm is a variation of the Remez exchange algorithm, with the change that it is specifically designed for FIR filters. It has become a standard method for FIR filter design. History of optimal FIR filter design In the 1960s, researchers within the field of analog filter design were using the Chebyshev approximation for filter design. During this time, it was well known that the best filters contain an equiripple characteristic in their frequency response magnitude and the elliptic filter (or Cauer filter) was optimal with regards to the Chebyshev approximation. When the digital filter revolution began in the 1960s, researchers used a bilinear transform to produce infinite impulse response (IIR) digital elliptic filters. They also recognized the potential for designing FIR filters to accomplish the same filtering task and soon the search was on for the optimal FIR filter using the Chebyshev approximation. It was well known in both mathematics and engineering that the optimal respo
https://en.wikipedia.org/wiki/Remez%20algorithm
The Remez algorithm or Remez exchange algorithm, published by Evgeny Yakovlevich Remez in 1934, is an iterative algorithm used to find simple approximations to functions, specifically, approximations by functions in a Chebyshev space that are the best in the uniform norm L∞ sense. It is sometimes referred to as Remes algorithm or Reme algorithm. A typical example of a Chebyshev space is the subspace of Chebyshev polynomials of order n in the space of real continuous functions on an interval, C[a, b]. The polynomial of best approximation within a given subspace is defined to be the one that minimizes the maximum absolute difference between the polynomial and the function. In this case, the form of the solution is precised by the equioscillation theorem. Procedure The Remez algorithm starts with the function to be approximated and a set of sample points in the approximation interval, usually the extrema of Chebyshev polynomial linearly mapped to the interval. The steps are: Solve the linear system of equations (where ), for the unknowns and E. Use the as coefficients to form a polynomial . Find the set of points of local maximum error . If the errors at every are of equal magnitude and alternate in sign, then is the minimax approximation polynomial. If not, replace with and repeat the steps above. The result is called the polynomial of best approximation or the minimax approximation algorithm. A review of technicalities in implementing the Remez algorithm
https://en.wikipedia.org/wiki/Minimax%20approximation%20algorithm
A minimax approximation algorithm (or L∞ approximation or uniform approximation) is a method to find an approximation of a mathematical function that minimizes maximum error. For example, given a function defined on the interval and a degree bound , a minimax polynomial approximation algorithm will find a polynomial of degree at most to minimize Polynomial approximations The Weierstrass approximation theorem states that every continuous function defined on a closed interval [a,b] can be uniformly approximated as closely as desired by a polynomial function. For practical work it is often desirable to minimize the maximum absolute or relative error of a polynomial fit for any given number of terms in an effort to reduce computational expense of repeated evaluation. Polynomial expansions such as the Taylor series expansion are often convenient for theoretical work but less useful for practical applications. Truncated Chebyshev series, however, closely approximate the minimax polynomial. One popular minimax approximation algorithm is the Remez algorithm. References External links Minimax approximation algorithm at MathWorld Numerical analysis
https://en.wikipedia.org/wiki/H%C3%B6lder%27s%20theorem
In mathematics, Hölder's theorem states that the gamma function does not satisfy any algebraic differential equation whose coefficients are rational functions. This result was first proved by Otto Hölder in 1887; several alternative proofs have subsequently been found. The theorem also generalizes to the -gamma function. Statement of the theorem For every there is no non-zero polynomial such that where is the gamma function. For example, define by Then the equation is called an algebraic differential equation, which, in this case, has the solutions and — the Bessel functions of the first and second kind respectively. Hence, we say that and are differentially algebraic (also algebraically transcendental). Most of the familiar special functions of mathematical physics are differentially algebraic. All algebraic combinations of differentially algebraic functions are differentially algebraic. Furthermore, all compositions of differentially algebraic functions are differentially algebraic. Hölder’s Theorem simply states that the gamma function, , is not differentially algebraic and is therefore transcendentally transcendental. Proof Let and assume that a non-zero polynomial exists such that As a non-zero polynomial in can never give rise to the zero function on any non-empty open domain of (by the fundamental theorem of algebra), we may suppose, without loss of generality, that contains a monomial term having a non-zero power of one of the indeterminates .
https://en.wikipedia.org/wiki/Homosphere
The homosphere is the layer of an atmosphere where the bulk gases are homogeneously mixed due to turbulent mixing or eddy diffusion. The bulk composition of the air is mostly uniform so the concentrations of molecules are the same throughout the homosphere. The top of the homosphere is called the homopause, also known as the turbopause. Above the homopause is the heterosphere, where diffusion is faster than mixing, and heavy gases decrease in density with altitude more rapidly than lighter gases. Some of the processes driving this uniformity include heating convection and air flow patterns. In the troposphere, rising warm air replaces higher cooler air which mix gases vertically. Wind patterns push air across the surface mixing it horizontally. At higher altitudes, other atmospheric circulation regimes exist, such as the Brewer-Dobson circulation in the terrestrial stratosphere, which mixes the air. In Earth's mesophere, atmospheric waves become unstable and dissipate, creating turbulent mixing of this region. Earth's homosphere The Earth's homosphere starts at the Earth's surface and extends to the turbopause at about 100 km. It incorporates all of the troposphere, stratosphere, mesosphere, and the lower part of the thermosphere. Chemically the homosphere is composed of 78% nitrogen, 21% oxygen, and trace amounts of other molecules, such as argon and carbon dioxide. It contains over 99% of the mass of the Earth's atmosphere. The density of air decreases with height in th
https://en.wikipedia.org/wiki/SGD%20%28disambiguation%29
SGD is the ISO 4217 code of the Singapore dollar, the currency of Singapore. SGD or sgd can also mean: Saccharomyces Genome Database, a yeast database Sargodha, a Pakistani city Secure global desktop, software by Tarantella, subsequently bought and used by Sun Microsystems and by Oracle Corporation SG Dynamo Dresden, a German association-football club Sliding glass door, a type of sliding door Smart Grid Device, an electronic device for smart grids Sønderborg Airport (IATA code SGD) Spanish Gangster Disciples, an American gang Speech-generating device, an electronic augmentative and alternative communication systems Stars Go Dim, an American pop-rock band Stochastic gradient descent, an optimization algorithm Submarine groundwater discharge, freshwater aquifer seepage into oceans Surigaonon language, based on its ISO 639-3 code sgd Sustainable Development Goals, a global development framework created in 2015 by the United Nations General Assembly
https://en.wikipedia.org/wiki/Jabo%20language
The Jabo language is a Kru language spoken by the Jabo people of Liberia. They have also been known in the past as the Gweabo. Classification Jabo is part of the Grebo language continuum, encoded by Ethnologue more specifically as a dialect of the Southern Grebo language. However, Jabo satisfies the ISO 639-3 criteria for an individual language: The shared core-vocabulary score for Jabo and Seaside Grebo is reported as being as low as 75%. The Jabo and Grebo political territories have been distinct at least since the time of the founding of "Maryland in Africa." The two peoples are currently in different counties (Grand Kru County and Maryland County), and the Jabo claim a greater affinity for the Kru (Krao) than for the Grebo. The physical separation of the Jabo and Grebo areas by the Deeah (Decoris) river is also an effective barrier to social intercourse and commerce. The Jabo and the Grebo have different origin legends, and thus have no shared identity. The Jabo are highly ethnocentric, and consider themselves to be a nation with its own language. On the other hand, the commercial interaction of the Grebo peoples, together with exogamy, produces widespread multilingualism, magnifying the impression of homogeneity of the varieties of Grebo. Additionally, the goal of literacy is facilitated by a unificationalist approach to the varieties. Sources The Jabo language is known to scientific linguistics in some level of detail because it was analysed by the respected linguist
https://en.wikipedia.org/wiki/Scaphoid%20fossa
In the pterygoid processes of the sphenoid, above the pterygoid fossa is a small, oval, shallow depression, the scaphoid fossa, which gives origin to the Tensor veli palatini. It is not the same as and has to be distinguished from the scaphoid fossa of the external ear or pinna. References External links Diagram - look for #28 (source here) Bones of the head and neck
https://en.wikipedia.org/wiki/Substrate%20%28marine%20biology%29
Stream substrate (sediment) is the material that rests at the bottom of a stream. There are several classification guides. One is: Mud – silt and clay. Sand – Particles between 0.06 and 2 mm in diameter. Granule – Between 2 and 4 mm in diameter. Pebble – Between 4 – 64 mm in diameter. Cobble – between 6.4 and 25.6 cm in diameter Boulder – more than 25.6 cm in diameter. Stream substrate can affect the life found within the stream habitat. Muddy streams generally have more sediment in the water, reducing clarity. Clarity is one guide to stream health. Marine substrate can be classified geologically as well. See Green et al., 1999 for a reference. Mollusks and clams that live in areas with substrate, and need them to survive, use their silky byssal threads to cling to it. See Cteniodes Ales for reference. See also Grain size Substrate (biology) Aquatic ecology Marine biology
https://en.wikipedia.org/wiki/Suprameatal%20spine
The inner end of the external acoustic meatus is closed, in the recent state, by the tympanic membrane; the upper limit of its outer orifice is formed by the posterior root of the zygomatic process, immediately below which there is sometimes seen a small spine, the suprameatal spine also called the spine of Henle, situated at the upper and posterior part of the orifice. References External links Bones of the head and neck
https://en.wikipedia.org/wiki/VLL
VLL may refer to: Virtual leased line, an Ethernet-based communication over IP/MPLS networks Visual Light Link, a component of a Lego robotics kit Valladolid Airport's IATA code
https://en.wikipedia.org/wiki/Hunt%20process
In probability theory, a Hunt process is a strong Markov process which is quasi-left continuous with respect to the minimum completed admissible filtration . It is named after Gilbert Hunt. See also Markov process Markov chain Shift of finite type References Markov processes
https://en.wikipedia.org/wiki/3%2C3%27%2C5%2C5%27-Tetramethylbenzidine
3,3′,5,5′-Tetramethylbenzidine or TMB is a chromogenic substrate used in staining procedures in immunohistochemistry as well as being a visualising reagent used in enzyme-linked immunosorbent assays (ELISA). TMB is a white solid that forms a pale blue-green liquid in solution with ethyl acetate. TMB is degraded by sunlight and by fluorescent lights. Used to detect hematuria as it turns blue in contact with hemoglobin. Enzymatic assay TMB can act as a hydrogen donor for the reduction of hydrogen peroxide to water by peroxidase enzymes such as horseradish peroxidase. The resulting one-electron oxidation product is a diimine-diamine complex, which causes the solution to take on a blue colour, and this colour change can be read on a spectrophotometer at the wavelengths of 370 and 650 nm. The reaction can be halted by addition of acid or another stop reagent. Using sulfuric acid turns TMB yellow, with a peak absorbance of 450 nm. The amount of converted TMB may be indexed by the amount of 450 nm light it absorbs. Material safety TMB should be kept out of direct sunlight as it is photosensitive. It is not known if TMB is carcinogenic and the evidence is contradictory: TMB is not mutagenic by the Ames test, and did not induce formation of tumors in a single-arm study of 24 rats. On that evidence, it has been used as a replacement for carcinogenic compounds such as benzidine and o-phenylenediamine. References Biphenyls Anilines
https://en.wikipedia.org/wiki/Delta%20baryon
The Delta baryons (or baryons, also called Delta resonances) are a family of subatomic particle made of three up or down quarks (u or d quarks), the same constituent quarks that make up the more familiar protons and neutrons. Properties Four closely related baryons exist:  (constituent quarks: uuu),  (uud),  (udd), and  (ddd), which respectively carry an electric charge of , , , and . The  baryons have a mass of about ; their third component of isospin and they are required to have an intrinsic spin of or higher (half-integer units). Ordinary nucleons (symbol N, meaning either a proton or neutron), by contrast, have a mass of about , and both intrinsic spin and isospin of . The  (uud) and  (udd) particles are higher-mass spin-excitations of the proton (, uud) and neutron (, udd), respectively. The and , however, have no direct nucleon analogues: For example, even though their charges are identical and their masses are similar, the  (ddd), is not closely related to the antiproton (, ). The Delta states discussed here are only the lowest-mass quantum excitations of the proton and neutron. At higher spins, additional higher mass Delta states appear, all defined by having constant or isospin (depending on charge), but with spin , , , ..., multiplied by . A complete listing of all properties of all these states can be found in Beringer et al. (2013). There also exist antiparticle Delta states with opposite charges, made up of the corresponding antiquarks. Discovery
https://en.wikipedia.org/wiki/PLCE
PLCE may refer to: Personal Load Carrying Equipment, the current tactical webbing system of the British Armed Forces PLCE1, an enzyme
https://en.wikipedia.org/wiki/Cloth%20menstrual%20pad
Cloth menstrual pads are cloth pads worn in the underwear to collect menstrual fluid (blood from uterine lining). They are a type of reusable menstrual hygiene product, and are an alternative to sanitary napkins or to menstrual cups. Because they can be reused, they are generally less expensive than disposable pads over time, and reduce the amount of waste produced. Generally they are made from layers of absorbent fabrics (such as cotton or hemp) which are worn during menstruation, post-birth bleeding or any other situation where it is necessary to absorb the flow of blood from the vagina, or to protect underwear from regular discharge of vaginal fluids. After use, they are washed, dried and then reused. Current use The majority of commercially available pads are manufactured by work-at-home moms or small businesses and can be purchased through some health food stores, specialty stores, and via Internet stores and marketplaces. They are available in a range of lengths and thicknesses, similar to disposable pads, with longer pads for night use and thinner and shorter pads for light use. Some manufacturers will allow the buyer to select the fabrics, shape and size of the pad so that they can be custom made to fit an individual and be as efficient as possible. Some people make their own cloth menstrual pads. These pads range from folded wash cloths to pads similar to the cloth menstrual pads available commercially. Cloth menstrual pads may be hand or machine washed, and t
https://en.wikipedia.org/wiki/Adobe%20Illustrator%20Artwork
Adobe Illustrator (AI) is a proprietary file format developed by Adobe Systems for representing single-page vector-based drawings in either the EPS or PDF formats. The .ai filename extension is used by Adobe Illustrator. The AI file format was originally a native format called PGF. PDF compatibility is achieved by embedding a complete copy of the PGF data within the saved PDF format file. This format is not related to .pgf using the same name Progressive Graphics Format. The same "dual path" approach as for PGF is used when saving EPS-compatible files in recent versions of Illustrator. Early versions of the AI file format are true EPS files with a restricted, compact syntax, with additional semantics represented by Illustrator-specific DSC comments that conform to DSC's Open Structuring Conventions. These files are identical to their corresponding Illustrator EPS counterparts, but with the EPS (procedure sets) omitted from the file and instead externally referenced using %%Include directives. Application support Editors Aside from Adobe Illustrator, the following applications can edit .ai files: Adobe After Effects can open and use .ai files for video editing. Affinity Designer can open .ai files with PDF stream. Cinema 4D can import .ai files for conversion to 3D images or for basic editing. CorelDRAW (proprietary program) can natively edit this file format with some limitations. Corel Paint Shop Pro (proprietary program) can natively edit this file format. DrawPlus
https://en.wikipedia.org/wiki/Curl
Curl or CURL may refer to: Science and technology Curl (mathematics), a vector operator that shows a vector field's rate of rotation Curl (programming language), an object-oriented programming language designed for interactive Web content cURL, a program and application library for transferring data with URLs Antonov An-26, an aircraft, NATO reporting name CURL Sports and weight training Curl (association football), is spin on the ball, which will make it swerve when kicked Curl, in the sport of curling, the curved path a stone makes on the ice or the act of playing; see Glossary of curling Biceps curl, a weight training exercises Leg curl, a weight training exercises Wrist curl, a weight training exercises Other uses Curl (Japanese snack), a brand of corn puffs Curl or ringlet, a lock of hair that grows in a curved, rather than straight, direction Consortium of University Research Libraries, an association of UK academic and research libraries Executive curl, the ring above a naval officer's gold lace or braid rank insignia People with the surname Kamren Curl (born 1999), American football player Martina Gangle Curl (1906–1994), American artist and activist Robert Curl (1933–2022), Nobel Laureate and emeritus professor of chemistry at Rice University Rod Curl (born 1943), American professional golfer Phil Curls (1942–2007), American politician See also Curling (disambiguation) Overlap (disambiguation) Spiral
https://en.wikipedia.org/wiki/PRTP
PRTP may refer to: Puerto Rican Workers' Revolutionary Party, a Puerto Rican political party Lactocepin, an enzyme
https://en.wikipedia.org/wiki/Relapsing%20fever
Relapsing fever is a vector-borne disease caused by infection with certain bacteria in the genus Borrelia, which is transmitted through the bites of lice or soft-bodied ticks (genus Ornithodoros). Signs and symptoms Most people who are infected develop sickness between 5 and 15 days after they are bitten. The symptoms may include a sudden fever, chills, headaches, muscle or joint aches, and nausea. A rash may also occur. These symptoms usually continue for 2 to 9 days, then disappear. This cycle may continue for several weeks if the person is not treated. Causes Louse-borne relapsing fever Along with Rickettsia prowazekii and Bartonella quintana, Borrelia recurrentis is one of three pathogens of which the body louse (Pediculus humanus humanus) is a vector. Louse-borne relapsing fever is more severe than the tick-borne variety. Louse-borne relapsing fever occurs in epidemics amid poor living conditions, famine and war in the developing world. It is currently prevalent in Ethiopia and Sudan. Mortality rate is 1% with treatment and 30–70% without treatment. Poor prognostic signs include severe jaundice, severe change in mental status, severe bleeding and a prolonged QT interval on ECG. Lice that feed on infected humans acquire the Borrelia organisms that then multiply in the gut of the louse. When an infected louse feeds on an uninfected human, the organism gains access when the victim crushes the louse or scratches the area where the louse is feeding. B. recurrentis inf
https://en.wikipedia.org/wiki/Boundary%20layer%20thickness
This page describes some of the parameters used to characterize the thickness and shape of boundary layers formed by fluid flowing along a solid surface. The defining characteristic of boundary layer flow is that at the solid walls, the fluid's velocity is reduced to zero. The boundary layer refers to the thin transition layer between the wall and the bulk fluid flow. The boundary layer concept was originally developed by Ludwig Prandtl and is broadly classified into two types, bounded and unbounded. The differentiating property between bounded and unbounded boundary layers is whether the boundary layer is being substantially influenced by more than one wall. Each of the main types has a laminar, transitional, and turbulent sub-type. The two types of boundary layers use similar methods to describe the thickness and shape of the transition region with a couple of exceptions detailed in the Unbounded Boundary Layer Section. The characterizations detailed below consider steady flow but is easily extended to unsteady flow. The bounded boundary layer description Bounded boundary layers is a name used to designate fluid flow along an interior wall such that the other interior walls induce a pressure effect on the fluid flow along the wall under consideration. The defining characteristic of this type of boundary layer is that the velocity profile normal to the wall often smoothly asymptotes to a constant velocity value denoted as ue(x). The bounded boundary layer concept
https://en.wikipedia.org/wiki/Ampliphase
Ampliphase is the brand name of an amplitude modulation system achieved by summing phase modulated carriers. This modulation and amplifier technology family was originally marketed by RCA for AM broadcast transmitters. The Ampliphase system was not developed by RCA, but by McClatchy Broadcasting in the mid-1930s. McClatchy Broadcasting acquired the technology via patent acquisition. The Ampliphase design was originally proposed by H. Chireix in 1935 and termed "Outphasing" by him. He sold the patent to McClatchy Broadcasting that later sold the patent to RCA. RCA turned "Outphasing" transmitters into a mass-produced product. RCA's first transmitters using this modulation system were at the 50,000 watt level but later lower power transmitters such as 10 kw and 5 kw were made. McClatchy Broadcasting was a former group owner of AM, FM and TV stations as well as a California publisher of newspapers. McClatchy Broadcasting should not be confused with the present-day McClatchey Broadcasting LLC, a different corporate entity. Only one known transmitter of this type is still in use. KFBK in California maintains an RCA BTA-50H (the "last gasp" of the Ampliphase concept) as an auxiliary transmitter. Radio Caroline has a working RCA BTA-50H on display aboard its radio ship Ross Revenge, however this transmitter has fallen out of use and is unlikely to be put back on the air since the Ross Revenge currently broadcasts via relay to a more efficient land-based transmitter. How it work
https://en.wikipedia.org/wiki/List%20of%20Blizzard%20Entertainment%20games
Blizzard Entertainment is an American video game developer and publisher based in Irvine, California. The company was founded in February 1991 under the name Silicon & Synapse by Michael Morhaime, Frank Pearce and Allen Adham. The company initially concentrated on porting other studio's games to computer platforms, as well RPM Racing (1991), a remake of Racing Destruction Set (1985). In 1992, however, the company began producing original games for home consoles with The Lost Vikings (1992) and Rock n' Roll Racing (1993), and beginning with Warcraft: Orcs & Humans (1994) it shifted to primarily focus on original computer games. The company was renamed to Blizzard Entertainment in 1994, and in 1996 the company Condor, then developing Diablo (1997), was merged with Blizzard and renamed to Blizzard North; it remained a separate studio for the company until it was closed in 2005. Blizzard was acquired by distributor Davidson & Associates in 1994, and a chain of acquisitions over the next four years led Blizzard to being a part of Vivendi Games, a subsidiary of Vivendi; when Vivendi Games merged with Activision in 2008 the resulting company was named Activision Blizzard. The name was retained when Activision Blizzard became an independent company in 2013, while Blizzard itself has been an independent subsidiary company throughout. Since the late 1990s, Blizzard has focused almost exclusively on the Warcraft, Diablo, StarCraft, and Overwatch series. All of Blizzard's games release
https://en.wikipedia.org/wiki/Jacobi%20eigenvalue%20algorithm
In numerical linear algebra, the Jacobi eigenvalue algorithm is an iterative method for the calculation of the eigenvalues and eigenvectors of a real symmetric matrix (a process known as diagonalization). It is named after Carl Gustav Jacob Jacobi, who first proposed the method in 1846, but only became widely used in the 1950s with the advent of computers. Description Let be a symmetric matrix, and be a Givens rotation matrix. Then: is symmetric and similar to . Furthermore, has entries: where and . Since is orthogonal, and have the same Frobenius norm (the square-root sum of squares of all components), however we can choose such that , in which case has a larger sum of squares on the diagonal: Set this equal to 0, and rearrange: if In order to optimize this effect, Sij should be the off-diagonal element with the largest absolute value, called the pivot. The Jacobi eigenvalue method repeatedly performs rotations until the matrix becomes almost diagonal. Then the elements in the diagonal are approximations of the (real) eigenvalues of S. Convergence If is a pivot element, then by definition for . Let denote the sum of squares of all off-diagonal entries of . Since has exactly off-diagonal elements, we have or . Now . This implies or ; that is, the sequence of Jacobi rotations converges at least linearly by a factor to a diagonal matrix. A number of Jacobi rotations is called a sweep; let denote the result. The previous estima
https://en.wikipedia.org/wiki/Proxy%20%28statistics%29
In statistics, a proxy or proxy variable is a variable that is not in itself directly relevant, but that serves in place of an unobservable or immeasurable variable. In order for a variable to be a good proxy, it must have a close correlation, not necessarily linear, with the variable of interest. This correlation might be either positive or negative. Proxy variable must relate to an unobserved variable, must correlate with disturbance, and must not correlate with regressors once the disturbance is controlled for. Examples In social sciences, proxy measurements are often required to stand in for variables that cannot be directly measured. This process of standing in is also known as operationalization. Per-capita gross domestic product (GDP) is often used as a proxy for measures of standard of living or quality of life. Montgomery et al. examine several proxies used, and point out limitations with each, stating "In poor countries, no single empirical measure can be expected to display all of the facets of the concept of income. Our judgment is that consumption per adult is the best measure among those collected in cross-sectional surveys." Likewise, country of origin or birthplace might be used as a proxy for race, or vice versa. Frost lists several examples of proxy variables: Widths of tree rings: proxy for historical environmental conditions; Per-capita GDP: proxy for quality of life; body mass index (BMI): proxy for true body fat percentage; years of education and/o
https://en.wikipedia.org/wiki/CARD%20%28domain%29
Caspase recruitment domains, or caspase activation and recruitment domains (CARDs), are interaction motifs found in a wide array of proteins, typically those involved in processes relating to inflammation and apoptosis. These domains mediate the formation of larger protein complexes via direct interactions between individual CARDs. CARDs are found on a strikingly wide range of proteins, including helicases, kinases, mitochondrial proteins, caspases, and other cytoplasmic factors. Basic features CARDs are a subclass of protein motif known as the death fold, which features an arrangement of six to seven antiparallel alpha helices with a hydrophobic core and an outer face composed of charged residues. Other motifs in this class include the pyrin domain (PYD), death domain (DD), and death effector domain (DED), all of which also function primarily in regulation of apoptosis and inflammatory responses. In apoptosis CARDs were originally characterized based on their involvement in the regulation of caspase activation and apoptosis. The basic six-helix structure of the domain appears to be conserved as far back as the ced-3 and ced-4 genes in C. elegans, the organism in which several components of the apoptotic machinery were first characterized. CARDs are present on a number of proteins that promote apoptosis, primarily caspases 1,2,4,5,9, and 15 in mammals. In the mammalian immune response IL-1 and IL-18 processing A number of CARDs have been shown to play a role in regu
https://en.wikipedia.org/wiki/Segal%27s%20conjecture
Segal's Burnside ring conjecture, or, more briefly, the Segal conjecture, is a theorem in homotopy theory, a branch of mathematics. The theorem relates the Burnside ring of a finite group G to the stable cohomotopy of the classifying space BG. The conjecture was made in the mid 1970s by Graeme Segal and proved in 1984 by Gunnar Carlsson. , this statement is still commonly referred to as the Segal conjecture, even though it now has the status of a theorem. Statement of the theorem The Segal conjecture has several different formulations, not all of which are equivalent. Here is a weak form: there exists, for every finite group G, an isomorphism Here, lim denotes the inverse limit, S* denotes the stable cohomotopy ring, B denotes the classifying space, the superscript k denotes the k-skeleton, and the subscript + denotes the addition of a disjoint basepoint. On the right-hand side, the hat denotes the completion of the Burnside ring with respect to its augmentation ideal. The Burnside ring The Burnside ring of a finite group G is constructed from the category of finite G-sets as a Grothendieck group. More precisely, let M(G) be the commutative monoid of isomorphism classes of finite G-sets, with addition the disjoint union of G-sets and identity element the empty set (which is a G-set in a unique way). Then A(G), the Grothendieck group of M(G), is an abelian group. It is in fact a free abelian group with basis elements represented by the G-sets G/H, where H varies over the s
https://en.wikipedia.org/wiki/Effective%20evolutionary%20time
The hypothesis of effective evolutionary time attempts to explain gradients, in particular latitudinal gradients, in species diversity. It was originally named "time hypothesis". Background Low (warm) latitudes contain significantly more species than high (cold) latitudes. This has been shown for many animal and plant groups, although exceptions exist (see latitudinal gradients in species diversity). An example of an exception is helminths of marine mammals, which have the greatest diversity in northern temperate seas, possibly because of small population densities of hosts in tropical seas that prevented the evolution of a rich helminth fauna, or because they originated in temperate seas and had more time for speciations there. It has become more and more apparent that species diversity is best correlated with environmental temperature and more generally environmental energy. These findings are the basis of the hypothesis of effective evolutionary time. Species have accumulated fastest in areas where temperatures are highest. Mutation rates and speed of selection due to faster physiological rates are highest, and generation times which also determine speed of selection, are smallest at high temperatures. This leads to a faster accumulation of species, which are absorbed into the abundantly available vacant niches, in the tropics. Vacant niches are available at all latitudes, and differences in the number of such niches can therefore not be the limiting factor for species r