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https://en.wikipedia.org/wiki/Ataxin%201
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Ataxin-1 is a DNA-binding protein which in humans is encoded by the ATXN1 gene.
Mutations in ataxin-1 cause spinocerebellar ataxia type 1, an inherited neurodegenerative disease characterized by a progressive loss of cerebellar neurons, particularly Purkinje neurons.
Genetics
ATXN1 is conserved across multiple species, including humans, mice, and Drosophila.
In humans, ATXN1 is located on the short arm of chromosome 6. The gene contains 9 exons, two of which are protein-coding. There is a CAG repeat in the coding sequence which is longer in humans than other species (6-38 uninterrupted CAG repeats in healthy humans versus 2 in the mouse gene). This repeat is prone to errors in DNA replication and can vary widely in length between individuals.
Structure
Notable features of the Ataxin-1 protein structure include:
A polyglutamine tract of variable length, encoded by the CAG repeat in ATXN1.
A region which mediates protein-protein interactions, known as the AXH domain
A nuclear localization sequence
A phosphorylation site which regulates the protein's stability and interactions with its binding partners
Function
The function of Ataxin-1 is not completely understood. It appears to be involved in regulating gene expression based on its location in the nucleus of the cell, its association with promoter regions of several genes, and its interactions with transcriptional regulators and parts of the RNA splicing machinery.
Interactions
Ataxin 1 has been shown to interact
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https://en.wikipedia.org/wiki/Schouten%20tensor
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In Riemannian geometry the Schouten tensor is a second-order tensor introduced by Jan Arnoldus Schouten defined for by:
where Ric is the Ricci tensor (defined by contracting the first and third indices of the Riemann tensor), R is the scalar curvature, g is the Riemannian metric, is the trace of P and n is the dimension of the manifold.
The Weyl tensor equals the Riemann curvature tensor minus the Kulkarni–Nomizu product of the Schouten tensor with the metric. In an index notation
The Schouten tensor often appears in conformal geometry because of its relatively simple conformal transformation law
where
Further reading
Arthur L. Besse, Einstein Manifolds. Springer-Verlag, 2007. See Ch.1 §J "Conformal Changes of Riemannian Metrics."
Spyros Alexakis, The Decomposition of Global Conformal Invariants. Princeton University Press, 2012. Ch.2, noting in a footnote that the Schouten tensor is a "trace-adjusted Ricci tensor" and may be considered as "essentially the Ricci tensor."
Wolfgang Kuhnel and Hans-Bert Rademacher, "Conformal diffeomorphisms preserving the Ricci tensor", Proc. Amer. Math. Soc. 123 (1995), no. 9, 2841–2848. Online eprint (pdf).
T. Bailey, M.G. Eastwood and A.R. Gover, "Thomas's Structure Bundle for Conformal, Projective and Related Structures", Rocky Mountain Journal of Mathematics, vol. 24, Number 4, 1191-1217.
See also
Weyl–Schouten theorem
Cotton tensor
Curvature tensors
Riemannian geometry
Tensors in general relativity
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https://en.wikipedia.org/wiki/Ataxin%207
|
Ataxin 7 (ATXN7) is a protein of the SCA7 gene, which contains 892 amino acids with an expandable poly(Q) region close to the N-terminus. The expandable poly(Q) motif region in the protein contributes crucially to spinocerebellar ataxia (SCA) pathogenesis by the induction of intranuclear inclusion bodies. ATXN7 is associated with both olivopontocerebellar atrophy type 3 (OPCA3) and spinocerebellar ataxia type 7 (SCA7).
CAG repeat leads to pathological protein misfolding. In ataxin-7 gene has shown to cause cerebellar and brainstem degeneration as well as retinal conerod dystrophy. Polyglutamine (polyQ) expansion at the N-terminus of ataxin-7 causes protein aggregation, leading to the symptoms of ataxia with visual loss.
Research suggest that silencing of ataxin-7 in the retina by RNAi can be a possible therapeutic strategy for patients with SCA7 retinal degeneration.
References
Further reading
External links
GeneReviews/NCBI/NIH/UW entry on Spinocerebellar Ataxia Type 7
Proteins
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https://en.wikipedia.org/wiki/Ataxin
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Ataxin is a type of nuclear protein. The class is called ataxin because mutated forms of these proteins and their corresponding genes were found to cause progressive ataxia.
Some examples, their coding genes and associated diseases include:
Ataxin 1, coded by ATXN1. Mutants of ataxin 1 with a polyglutamine expansion cause SCA1.
Ataxin 2, coded by ATXN2. It is known to cause SCA2 with polyglutamine expansion.
Ataxin 3, coded by ATXN3. Machado-Joseph disease is caused by polyglutamine expansions in ataxin 3.
Ataxin 7, coded by ATXN7. Polyglutamine expansions in Ataxin 7 cause SCA7.
Ataxin 8, coded by ATXN8. Ataxin 8 does not cause an ataxic order, but a gene on the opposite strand, ATXN8OS, causes Spinocerebellar ataxia type 8 with CTG expansion.
Ataxin 10, coded by ATXN10. It is associated with the pentanucleotide disorder, SCA10.
Frataxin, follows a similar naming convention and is coded by the FXN gene. GAA repeat expansions in a non-coding region of FXN cause Friedreich's ataxia when both copies of the gene are affected.
References
Protein families
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https://en.wikipedia.org/wiki/Weyl%E2%80%93Schouten%20theorem
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In the mathematical field of differential geometry, the existence of isothermal coordinates for a (pseudo-)Riemannian metric is often of interest. In the case of a metric on a two-dimensional space, the existence of isothermal coordinates is unconditional. For higher-dimensional spaces, the Weyl–Schouten theorem (named after Hermann Weyl and Jan Arnoldus Schouten) characterizes the existence of isothermal coordinates by certain equations to be satisfied by the Riemann curvature tensor of the metric.
Existence of isothermal coordinates is also called conformal flatness, although some authors refer to it instead as local conformal flatness; for those authors, conformal flatness refers to a more restrictive condition.
Theorem
In terms of the Riemann curvature tensor, the Ricci tensor, and the scalar curvature, the Weyl tensor of a pseudo-Riemannian metric of dimension is given by
The Schouten tensor is defined via the Ricci and scalar curvatures by
As can be calculated by the Bianchi identities, these satisfy the relation that
The Weyl–Schouten theorem says that for any pseudo-Riemannian manifold of dimension :
If then the manifold is conformally flat if and only if its Weyl tensor is zero.
If then the manifold is conformally flat if and only if its Schouten tensor is a Codazzi tensor.
As known prior to the work of Weyl and Schouten, in the case , every manifold is conformally flat. In all cases, the theorem and its proof are entirely local, so the topology of the man
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https://en.wikipedia.org/wiki/Malonyl-CoA%20decarboxylase
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Malonyl-CoA decarboxylase (), (which can also be called MCD and malonyl-CoA carboxyl-lyase) is found in bacteria and humans and has important roles in regulating fatty acid metabolism and food intake, and it is an attractive target for drug discovery. It is an enzyme associated with Malonyl-CoA decarboxylase deficiency. In humans, it is encoded by the MLYCD gene.
Its main function is to catalyze the conversion of malonyl-CoA into acetyl-CoA and carbon dioxide. It is involved in fatty acid biosynthesis. To some degree, it reverses the action of Acetyl-CoA carboxylase.
Structure
MCD presents two isoforms which can be transcribed form one gene: a long isoform (54kDa), distributed in mitochondria, and a short isoform (49kDa) that can be found in peroxisomes and cytosol. The long isoform includes a sequence of signaling towards mitochondria in the N-terminus; whereas the short one only contains the typical sequence of peroxisomal signaling PTS1 in the C-terminus, also shared by the long isoform.
MCD is a protein tetramer, an oligomer formed by a dimer of heterodimers related by an axis of binary symmetry with a rotation angle of about 180 degrees. The strong structural asymmetry between the monomers of the heterodimer suggests a half of the sites reactivity, in which only half of the active sites are functional simultaneously.
Each monomer contains basically two domains:
The N-terminus one, which is involved in oligomerization and has a helical structure of eight helixes or
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https://en.wikipedia.org/wiki/London%20Underground%20H%20Stock
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The H Stock classification has been used twice for London Underground stock.
The first time was the designation given to examples of B stock that were rebuilt in the 1920s. These were withdrawn from service between 1934 and 1946.
The second time that stock was classified H Stock (H standing for Handworked doors) was in the late 1940s. The surviving examples of C stock, D stock, and E stock were reclassified and the last of these cars remained in use until 1958.
Also included were the cars of G stock, K stock, L stock, M stock, and N stock. These cars were classified as H stock until they were rebuilt into Q stock.
References
Metropolitan District Railway
H
Train-related introductions in 1920
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https://en.wikipedia.org/wiki/History%20of%20mathematical%20notation
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The history of mathematical notation includes the commencement, progress, and cultural diffusion of mathematical symbols and the conflict of the methods of notation confronted in a notation's move to popularity or inconspicuousness. Mathematical notation comprises the symbols used to write mathematical equations and formulas. Notation generally implies a set of well-defined representations of quantities and symbols operators. The history includes Hindu–Arabic numerals, letters from the Roman, Greek, Hebrew, and German alphabets, and a host of symbols invented by mathematicians over the past several centuries.
The development of mathematical notation can be divided in stages:
The "rhetorical" stage is where calculations are performed by words and no symbols are used.
The "syncopated" stage is where frequently used operations and quantities are represented by symbolic syntactical abbreviations. From ancient times through the post-classical age, bursts of mathematical creativity were often followed by centuries of stagnation. As the early modern age opened and the worldwide spread of knowledge began, written examples of mathematical developments came to light.
The "symbolic" stage is where comprehensive systems of notation supersede rhetoric. Beginning in Italy in the 16th century, new mathematical developments, interacting with new scientific discoveries were made at an increasing pace that continues through the present day. This symbolic system was in use by medieval Ind
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https://en.wikipedia.org/wiki/Graeffe%27s%20method
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In mathematics, Graeffe's method or Dandelin–Lobachesky–Graeffe method is an algorithm for finding all of the roots of a polynomial. It was developed independently by Germinal Pierre Dandelin in 1826 and Lobachevsky in 1834. In 1837 Karl Heinrich Gräffe also discovered the principal idea of the method. The method separates the roots of a polynomial by squaring them repeatedly. This squaring of the roots is done implicitly, that is, only working on the coefficients of the polynomial. Finally, Viète's formulas are used in order to approximate the roots.
Dandelin–Graeffe iteration
Let be a polynomial of degree
Then
Let be the polynomial which has the squares as its roots,
Then we can write:
can now be computed by algebraic operations on the coefficients of the polynomial alone. Let:
then the coefficients are related by
Graeffe observed that if one separates into its odd and even parts:
then one obtains a simplified algebraic expression for :
This expression involves the squaring of two polynomials of only half the degree, and is therefore used in most implementations of the method.
Iterating this procedure several times separates the roots with respect to their magnitudes. Repeating k times gives a polynomial of degree :
with roots
If the magnitudes of the roots of the original polynomial were separated by some factor , that is, , then the roots of the k-th iterate are separated by a fast growing factor
.
Classical Graeffe's method
Next the Vieta r
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https://en.wikipedia.org/wiki/Follicular%20dendritic%20cells
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Follicular dendritic cells (FDC) are cells of the immune system found in primary and secondary lymph follicles (lymph nodes) of the B cell areas of the lymphoid tissue. Unlike dendritic cells (DC), FDCs are not derived from the bone-marrow hematopoietic stem cell, but are of mesenchymal origin.
Possible functions of FDC include: organizing lymphoid tissue's cells and microarchitecture, capturing antigen to support B cell, promoting debris removal from germinal centers, and protecting against autoimmunity.
Disease processes that FDC may contribute include primary FDC-tumor, chronic inflammatory conditions, HIV-1 infection development, and neuroinvasive scrapie.
Location and molecular markers
Follicular DCs are a non-migratory population found in primary and secondary follicles of the B cell areas of lymph nodes, spleen, and mucosa-associated lymphoid tissue (MALT). They form a stable network due to intercellular connections between FDCs processes and intimate interaction with follicular B cells. Follicular DCs network typically forms the center of the follicle and does not extend from the follicle to the interfollicular regions or T-cell zone. Supposedly, this separation from the sites of earliest antigen processing and capture provide a protected environment in which opsonized antigens can be displayed for a long time without being proteolyzed or removed by phagocytic cells. Follicular DCs have high expression of complement receptors CR1 and CR2 (CD 35 and CD 21 respective
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https://en.wikipedia.org/wiki/Sulbutiamine
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Sulbutiamine (brand names Arcalion, Enerion) is a synthetic derivative of thiamine (vitamin B1). In France, it is used to treat symptoms of weakness or fatigue. It is also sold as a dietary supplement. Sulbutiamine was discovered in Japan as part of an effort to develop useful thiamine derivatives.
Medical use
Sulbutiamine is used to treat asthenia (symptoms of fatigue or weakness), though is not clear if it is effective in alleviating tiredness. It is also used to treat thiamine deficiency and poor concentration. Being a potent cholinergic anxiolytic , Sulbutiamine is a popular nootropic, with users reporting enhanced memory, focus and improved mood and motivation. Endurance athletes may use it to try to enhance their performance.
Adverse effects
Adverse effects found in clinical trials are usually limited to headache and gastrointestinal discomfort when high doses are used. While daily use can result in tolerance and paradoxical drowsiness, increasing the dose is strongly discouraged and side effects can include diarrhea, bladder infections, bronchitis, back pain, abdominal pain, insomnia, constipation, gastroenteritis, headache, vertigo, and sore throat.
History
Efforts to develop thiamine derivatives with better bioavailability than thiamine were conducted in the 1950s, mainly in Japan. These efforts led to the discovery of allicin (diallyl thiosulfinate) in garlic, which became a model for medicinal chemistry efforts to create other thiamine disulfides. The resul
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https://en.wikipedia.org/wiki/Castor%20%28band%29
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Castor was an American indie rock/emo band from Champaign-Urbana, Illinois. Formed in 1994, they were known for their "fluid" sound, often changing time signatures several times in a song while maintaining the flow of the music. They released two albums, the first self titled in 1995, the second Tracking Sounds Alone in 1998. Both albums are now out of print and only available in digital format online.
Singer and guitarist Jeff Garber and bassist Derek Niedringhaus were in a small local band together called Flower in the southern Illinois/St. Louis area. They released one E.P. and one full length recording under the band name Flower before disbanding. The two continued working together and recorded an album under the band name "Big Bright Lights" in 1997 which was not released until 2001.
During their existence they toured with other influential Champaign-Urbana acts Braid and Hum amongst others.
Garber went on to play in the bands National Skyline and Year of the Rabbit. Niedringhaus also joined National Skyline, later forming Centaur with Hum singer/guitarist Matt Talbott, the producer of their only single.
On February 24, 2018, Castor reunited for the first time in 20 years, opening for Hum at Delmar Hall in St. Louis, MO.
Former line-up
Ben Eversmann
Jeff Garber
Derek Niedringhaus
Jason Vance
Discography
Studio albums
Castor (1995)
Tracking Sounds Alone (1998)
Singles
"Carnival/Miss Atlantic" (1997)
Compilations
"Repousse" and "Silent Type" on the Cover The E
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https://en.wikipedia.org/wiki/Brahmin%20Tamil
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Brahmin Tamil is the name of a dialect of Tamil traditionally spoken by Tamil Brahmins. The dialect, largely, uses Classical Tamil along with a heavy proportion of Sanskrit derivatives. According to the linguist Sabari Ganesh, Brahmin Tamil dialect is closest to the Central Tamil dialect, particularly, the variant spoken by the once dominant and highly educated community colloquial spoken Tamil of Vellalars and Mudaliyars.
History
During the early 1900s, Brahmin Tamil was used as the lingua-franca for inter-caste communication. The principal characters in the Tamil films of the period (1930s and 1940s) also spoke the Brahmin dialect. However, with the rise of the Pure Tamil Movement and the entry of Dravidian ideologues into Tamil cinema in the 1950s, Brahmin Tamil was gradually displaced from public spheres. Today, Brahmin Tamil is used in films and television soaps centred on the Brahmin society. Brahmin Tamil, has however, continued to flourish among the Brahmin community including the expatriates. Often non-Brahmins use this dialect in soaps and films for comic effect while engaging with Brahmins conversationally. And Brahmins effortlessly code switch by speaking the standard Tamil while engaging with non-Brahmins and revert to Brahmin Tamil when conversing among themselves.
The first systematic study of Brahmin Tamil was undertaken by Jules Bloch in 1910. However, the most detailed study was conducted by A K Ramanujan and William Bright in the 1960s. More recent rese
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https://en.wikipedia.org/wiki/Anticipatory%20scheduling
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Anticipatory scheduling is an algorithm for scheduling hard disk input/output (I/O scheduling). It seeks to increase the efficiency of disk utilization by "anticipating" future synchronous read operations.
I/O scheduling
"Deceptive idleness" is a situation where a process appears to be finished reading from the disk when it is actually processing data in preparation of the next read operation. This will cause a normal work-conserving I/O scheduler to switch to servicing I/O from an unrelated process. This situation is detrimental to the throughput of synchronous reads, as it degenerates into a seeking workload.
Anticipatory scheduling overcomes deceptive idleness by pausing for a short time (a few milliseconds) after a read operation in anticipation of another close-by read requests.
Anticipatory scheduling yields significant improvements in disk utilization for some workloads. In some situations the Apache web server may achieve up to 71% more throughput from using anticipatory scheduling.
The Linux anticipatory scheduler may reduce performance on disks using Tagged Command Queuing (TCQ), high performance disks, and hardware RAID arrays. An anticipatory scheduler (AS) was the default Linux kernel scheduler between 2.6.0 and 2.6.18, by which time it was replaced by the CFQ scheduler.
As of kernel version 2.6.33, the Anticipatory scheduler has been removed from the Linux kernel. The reason being that while useful, the scheduler's effects could be achieved through tune
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https://en.wikipedia.org/wiki/Blast%20wave
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In fluid dynamics, a blast wave is the increased pressure and flow resulting from the deposition of a large amount of energy in a small, very localised volume. The flow field can be approximated as a lead shock wave, followed by a self-similar subsonic flow field. In simpler terms, a blast wave is an area of pressure expanding supersonically outward from an explosive core. It has a leading shock front of compressed gases. The blast wave is followed by a blast wind of negative gauge pressure, which sucks items back in towards the center. The blast wave is harmful especially when one is very close to the center or at a location of constructive interference. High explosives that detonate generate blast waves.
Sources
High-order explosives (HE) are more powerful than low-order explosives (LE). HE detonate to produce a defining supersonic over-pressurization shock wave. Several sources of HE include trinitrotoluene, C-4, Semtex, nitroglycerin, and ammonium nitrate fuel oil (ANFO). LE deflagrate to create a subsonic explosion and lack HE's over-pressurization wave. Sources of LE include pipe bombs, gunpowder, and most pure petroleum-based incendiary bombs such as Molotov cocktails or aircraft improvised as guided missiles. HE and LE induce different injury patterns. Only HE produce true blast waves.
History
The classic flow solution—the so-called Taylor–von Neumann–Sedov blast wave solution—was independently devised by John von Neumann and British mathematician Geoffrey Ingram Ta
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https://en.wikipedia.org/wiki/DFFITS
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In statistics, DFFIT and DFFITS ("difference in fit(s)") are diagnostics meant to show how influential a point is in a linear regression, first proposed in 1980.
DFFIT is the change in the predicted value for a point, obtained when that point is left out of the regression:
where and are the prediction for point i with and without point i included in the regression.
DFFITS is the Studentized DFFIT, where Studentization is achieved by dividing by the estimated standard deviation of the fit at that point:
where is the standard error estimated without the point in question, and is the leverage for the point.
DFFITS also equals the products of the externally Studentized residual () and the leverage factor ():
Thus, for low leverage points, DFFITS is expected to be small, whereas as the leverage goes to 1 the distribution of the DFFITS value widens infinitely.
For a perfectly balanced experimental design (such as a factorial design or balanced partial factorial design), the leverage for each point is p/n, the number of parameters divided by the number of points. This means that the DFFITS values will be distributed (in the Gaussian case) as times a t variate. Therefore, the authors suggest investigating those points with DFFITS greater than .
Although the raw values resulting from the equations are different, Cook's distance and DFFITS are conceptually identical and there is a closed-form formula to convert one value to the other.
Development
Previously when assessi
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https://en.wikipedia.org/wiki/Heterologous
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The term heterologous has several meanings in biology.
Gene expression
In cell biology and protein biochemistry, heterologous expression means that a protein is experimentally put into a cell that does not normally make (i.e., express) that protein. Heterologous (meaning 'derived from a different organism') refers to the fact that often the transferred protein was initially cloned from or derived from a different cell type or a different species from the recipient.
Typically the protein itself is not transferred, but instead the 'correctly edited' genetic material coding for the protein (the complementary DNA or cDNA) is added to the recipient cell. The genetic material that is transferred typically must be within a format that encourages the recipient cell to express the cDNA as a protein (i.e., it is put in an expression vector).
Methods for transferring foreign genetic material into a recipient cell include transfection and transduction. The choice of recipient cell type is often based on an experimental need to examine the protein's function in detail, and the most prevalent recipients, known as heterologous expression systems, are chosen usually because they are easy to transfer DNA into or because they allow for a simpler assessment of the protein's function.
Stem cells
In stem cell biology, a heterologous transplant refers to cells from a mixed population of donor cells. This is in contrast to an autologous transplant where the cells are derived from the s
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https://en.wikipedia.org/wiki/Polycomb-group%20proteins
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Polycomb-group proteins (PcG proteins) are a family of protein complexes first discovered in fruit flies that can remodel chromatin such that epigenetic silencing of genes takes place. Polycomb-group proteins are well known for silencing Hox genes through modulation of chromatin structure during embryonic development in fruit flies (Drosophila melanogaster). They derive their name from the fact that the first sign of a decrease in PcG function is often a homeotic transformation of posterior legs towards anterior legs, which have a characteristic comb-like set of bristles.
In insects
In Drosophila, the Trithorax-group (trxG) and Polycomb-group (PcG) proteins act antagonistically and interact with chromosomal elements, termed Cellular Memory Modules (CMMs). Trithorax-group (trxG) proteins maintain the active state of gene expression while the Polycomb-group (PcG) proteins counteract this activation with a repressive function that is stable over many cell generations and can only be overcome by germline differentiation processes. Polycomb Gene complexes or PcG silencing consist of at least three kinds of multiprotein complex Polycomb Repressive Complex 1 (PRC1), PRC2 and PhoRC. These complexes work together to carry out their repressive effect. PcGs proteins are evolutionarily conserved and exist in at least two separate protein complexes; the PcG repressive complex 1 (PRC1) and the PcG repressive complex 2–4 (PRC2/3/4). PRC2 catalyzes trimethylation of lysine 27 on histone H
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https://en.wikipedia.org/wiki/Limited-memory%20BFGS
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Limited-memory BFGS (L-BFGS or LM-BFGS) is an optimization algorithm in the family of quasi-Newton methods that approximates the Broyden–Fletcher–Goldfarb–Shanno algorithm (BFGS) using a limited amount of computer memory. It is a popular algorithm for parameter estimation in machine learning. The algorithm's target problem is to minimize over unconstrained values of the real-vector where is a differentiable scalar function.
Like the original BFGS, L-BFGS uses an estimate of the inverse Hessian matrix to steer its search through variable space, but where BFGS stores a dense approximation to the inverse Hessian (n being the number of variables in the problem), L-BFGS stores only a few vectors that represent the approximation implicitly. Due to its resulting linear memory requirement, the L-BFGS method is particularly well suited for optimization problems with many variables. Instead of the inverse Hessian Hk, L-BFGS maintains a history of the past m updates of the position x and gradient ∇f(x), where generally the history size m can be small (often ). These updates are used to implicitly do operations requiring the Hk-vector product.
Algorithm
The algorithm starts with an initial estimate of the optimal value, , and proceeds iteratively to refine that estimate with a sequence of better estimates . The derivatives of the function are used as a key driver of the algorithm to identify the direction of steepest descent, and also to form an estimate of the Hessian matrix (sec
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https://en.wikipedia.org/wiki/CD1D
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CD1D is the human gene that encodes the protein CD1d, a member of the CD1 (cluster of differentiation 1) family of glycoproteins expressed on the surface of various human antigen-presenting cells. They are non-classical MHC proteins, related to the class I MHC proteins, and are involved in the presentation of lipid antigens to T cells. CD1d is the only member of the group 2 CD1 molecules.
Biological significance
CD1d-presented lipid antigens activate a special class of T cells, known as natural killer T (NKT) cells, through the interaction with the T-cell receptor present on NKT membranes. When activated, NKT cells rapidly produce Th1 and Th2 cytokines, typically represented by interferon-gamma and interleukin 4 production.
Nomenclature
CD1d is also known as R3G1
Ligands
Some of the known ligands for CD1d are:
α-galactosylceramide (α-GalCer), a compound originally derived from the marine sponge Agelas mauritanius with no physiological role but great research utility.
α-glucuronyl- and α-galacturonyl- ceramides, a family of compounds of microbial origin which can be found, for example, on the cell wall of Sphingomonas, a ubiquitous Gram-negative bacterium. The related β-D-glucopyranosylceramide is accumulated in antigen-presenting cells after infection, where it serves to activate invariant NKTs (iNKTs), a special kind of NKT.
iGb3, a self antigen which has been implied in iNKT selection.
HS44, a synthetic amino cyclitolic ceramide analogue which has less contact with
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https://en.wikipedia.org/wiki/Riot%20in%20Cell%20Block%2011
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Riot in Cell Block 11 is a 1954 American film noir crime film directed by Don Siegel and starring Neville Brand, Emile Meyer, Frank Faylen, Leo Gordon and Robert Osterloh. Director Quentin Tarantino called it "the best prison film ever made."
Plot
One night, several prison inmates take guards prisoner to protest brutal conditions in their prison. They then make their demands known to prison warden Reynolds (Emile Meyer), a liberal-minded administrator who has complained for many years about the same conditions. James V. Dunn (Neville Brand), the prisoners' leader, meets the press outside the cell block and makes demands that they will no longer tolerate the brutal guards, substandard food, overcrowding, and barely livable conditions.
The next day inmates from two other blocks start a riot but they are forced back into the cell blocks by the state police. Negotiations between the inmates and prison officials are stymied by the state politicians who do not want to make any concessions.
Meanwhile, factions within the prisoners begin to vie for power and control within the rebellious cell block. At the same time, the state police are given the go ahead to blow a hole in the wall to end the siege. But unknown to them, the inmates inside create a human shield by tying the hostages to the interior wall.
Just in the nick of time, the governor agrees to sign a petition from the prisoners. The riot ends when the inmates see the next-day newspapers saying that they had won. But it i
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https://en.wikipedia.org/wiki/Sphere%20%28website%29
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Sphere was a blog search engine. The Sphere search engine delivered blog posts based on algorithms that combine semantic matching with authority factors to deliver results relevant to the search query.
Sphere also organized bloggers by topic.
The company produced an application called Sphere It! allowing users to seek blog posts related to news articles based on the contents of a particular web page they're viewing. The function was accessed from a browser navigation bar plug-in. Upon clicking the plug-in button, a semantic analysis was performed on the text within the page and blog posts related to the text of the article were returned. The search engine required that JavaScript is turned on in the visitor's browser.
Sphere had a variety of content distribution venues among major publishers where blog results from Sphere were presented, contextually, within news stories or other content.
Sphere was founded by Tony Conrad, CEO, Martin Remy, CTO, Steve Nieker, CIO and Toni Schneider, Advisor. The company was based in San Francisco, CA.
In April, 2008, Sphere was acquired by AOL to be operated as a wholly owned subsidiary.
In 2010, Sphere was merged into AOL News.
See also
Bloglines
Technorati
References
Blog search engines
Defunct internet search engines
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https://en.wikipedia.org/wiki/Phenylpropiolic%20acid
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Phenylpropiolic acid, C6H5CCCO2H, formed by the action of alcoholic potash on cinnamic acid dibromide, C6H5CHBrCHBrCO2H, crystallizes in long needles or prisms which melt at 136–137 °C. When heated with water to 120 °C, it yields phenylacetylene (C6H5CCH). Chromic acid oxidizes it to benzoic acid; zinc and acetic acid reduce it to cinnamic acid, C6H5CH=CHCO2H, whilst sodium amalgam reduces it to hydrocinnamic acid, C6H5CH2CH2CO2H. Ortho-nitrophenylpropiolic acid, NO2C6H4CCCO2H, prepared by the action of alcoholic potash on ortho-nitrocinnamic acid dibromide, crystallizes in needles which decompose when heated to 155–156 °C. It is readily converted into indigo.
References
Phenyl compounds
Alkyne derivatives
Carboxylic acids
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https://en.wikipedia.org/wiki/Frederik%20Marcus%20Knuth%20%28taxonomist%29
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Frederik Marcus Knuth, 9th Count of Knuthenborg (5 May 1904 – 14 June 1970) was a Danish taxonomist especially known for the collection and classification of cactuses. He collected and described many new species.
According to the Bovrup File Knuth was a member of DNSAP.
References
1904 births
1970 deaths
20th-century Danish botanists
20th-century Danish landowners
Botanists active in South America
Danish counts
Danish explorers
Danish Nazis
Knuth family
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https://en.wikipedia.org/wiki/Pointer%20machine
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In theoretical computer science, a pointer machine is an atomistic abstract computational machine whose storage structure is a graph. A pointer algorithm could also be an algorithm restricted to the pointer machine model.
Some particular types of pointer machines are called a linking automaton, a KU-machine, an SMM, an atomistic LISP machine, a tree-pointer machine, etc.
Pointer machines do not have arithmetic instructions. Computation proceeds only by reading input symbols, modifying and doing various tests on its storage structure—the pattern of nodes and pointers, and outputting symbols based on the tests. In this sense, the model is similar to the Turing machine.
Types of "pointer machines"
Both Gurevich and Ben-Amram list a number of very similar "atomistic" models of "abstract machines"; Ben-Amram believes that the "atomistic models" must be distinguished from "high-level" models. The following atomistic models will be presented below:
Schönhage's storage modification machines (SMM),
Kolmogorov–Uspenskii machines (KUM or KU-Machines).
Ben-Amram also presents the following varieties, not further discussed in this article:
Atomistic pure-LISP machine (APLM)
Atomistic full-LISP machine (AFLM),
General atomistic pointer machines,
Jone's I language (two types).
Schönhage's storage modification machine (SMM) model
The following presentation follows van Emde Boas.<ref name="vEB">Peter van Emde Boas, Machine Models and Simulations pp. 3–66 in: Jan van Leeuwen, ed
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https://en.wikipedia.org/wiki/Critical%20speed
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In solid mechanics, in the field of rotordynamics, the critical speed is the theoretical angular velocity that excites the natural frequency of a rotating object, such as a shaft, propeller, leadscrew, or gear. As the speed of rotation approaches the object's natural frequency, the object begins to resonate, which dramatically increases system vibration. The resulting resonance occurs regardless of orientation. When the rotational speed is equal to the numerical value of the natural vibration, then that speed is referred to as critical speed.
Critical speed of shafts
All rotating shafts, even in the absence of external load, will deflect during rotation. The unbalanced mass of the rotating object causes deflection that will create resonant vibration at certain speeds, known as the critical speeds. The magnitude of deflection depends upon the following:
Stiffness of the shaft and its support
Total mass of shaft and attached parts
Unbalance of the mass with respect to the axis of rotation
The amount of damping in the system
In general, it is necessary to calculate the critical speed of a rotating shaft, such as a fan shaft, in order to avoid issues with noise and vibration.
Critical speed equation
Like vibrating strings and other elastic structures, shafts and beams can vibrate in different mode shapes, with corresponding natural frequencies. The first vibrational mode corresponds to the lowest natural frequency. Higher modes of vibration correspond to higher natural freque
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https://en.wikipedia.org/wiki/Tunnell%27s%20theorem
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In number theory, Tunnell's theorem gives a partial resolution to the congruent number problem, and under the Birch and Swinnerton-Dyer conjecture, a full resolution.
Congruent number problem
The congruent number problem asks which positive integers can be the area of a right triangle with all three sides rational. Tunnell's theorem relates this to the number of integral solutions of a few fairly simple Diophantine equations.
Theorem
For a given square-free integer n, define
Tunnell's theorem states that supposing n is a congruent number, if n is odd then 2An = Bn and if n is even then 2Cn = Dn. Conversely, if the Birch and Swinnerton-Dyer conjecture holds true for elliptic curves of the form , these equalities are sufficient to conclude that n is a congruent number.
History
The theorem is named for Jerrold B. Tunnell, a number theorist at Rutgers University, who proved it in .
Importance
The importance of Tunnell's theorem is that the criterion it gives is testable by a finite calculation. For instance, for a given , the numbers can be calculated by exhaustively searching through in the range .
See also
Birch and Swinnerton-Dyer conjecture
Congruent number
References
Theorems in number theory
Diophantine equations
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https://en.wikipedia.org/wiki/Producer%27s%20risk
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Producer's risk is the probability that a good product will be rejected as a bad product by the consumer.
When the acceptance reliability level (ARL) is pi0, we can define the producer's risk as:
P(Test is Failed|pi0)
It calculates the probability of loss from (1) rejecting a batch which, in fact, should have been accepted, or (2) accepting a batch that, in fact, will be rejected by the customer.
See also
consumer's risk
Quality control
References
Production economics
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https://en.wikipedia.org/wiki/Loose%20Cannons%20%281990%20film%29
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Loose Cannons is a 1990 American action comedy film written by Richard Matheson, Richard Christian Matheson and Bob Clark, who also directed the film. The film stars Gene Hackman as a hard-nosed cop who is teamed up with a detective with multiple-personality disorder, played by Dan Aykroyd, to uncover a long-lost Nazi sex tape, featuring Adolf Hitler, which would jeopardize the political future of the German chancellor-elect. The theme song features vocals by Katey Sagal and Aykroyd.
Upon release by Tri-Star Pictures on February 9, 1990, the film was a critical and financial bomb, bringing in only $5.5 million worldwide on a $15 million budget.
Plot
A film is found that features young German officer Kirk von Metz sleeping with Adolf Hitler. Years later, von Metz, running for chancellor of West Germany, arranges for anyone who has seen the film to be murdered. The killings take place in the Washington D.C. area, and Metropolitan Police officers MacArthur "Mac" Stern and Ellis Fielding are sent to investigate the crimes.
Ellis suffers from a dissociative identity disorder stemming from a disastrous undercover drug sting, which is aggravated when he is confronted with violence. This results in several episodes where he blacks out and assumes the personalities of popular culture characters, including Popeye, Captain Kirk and the Road Runner.
Mac and Ellis attempt to track down the film through pornographer Harry "The Hippo" Gutterman, who informs them that to do so they need
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https://en.wikipedia.org/wiki/Bias%20tee
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A bias tee is a three-port network used for setting the DC bias point of some electronic components without disturbing other components. The bias tee is a diplexer. The low-frequency port is used to set the bias; the high-frequency port passes the radio-frequency signals but blocks the biasing levels; the combined port connects to the device, which sees both the bias and RF. It is called a tee because the 3 ports are often arranged in the shape of a T.
Design
Conceptually, the bias tee can be viewed as an ideal capacitor that allows AC through but blocks the DC bias and an ideal inductor that blocks AC but allows DC. Although some bias tees can be made with a simple inductor and capacitor, wideband bias tees are considerably more complicated because practical components have parasitic elements.
Bias tees are designed for transmission-line environments. Typically, the characteristic impedance will be 50 Ohms or 75 Ohms. The impedance of the capacitor () is chosen to be much less than , and the impedance of the inductor () is chosen to be much greater than :
where is the angular frequency (in radians per second) and is the frequency (in Hertz).
Bias tees are designed to operate over a range of signal frequencies. The reactances are chosen to have minimal impact at the lowest frequency.
For wide-range bias tees, the inductive reactance must be large in value, even at the lowest frequency, hence the dimensions of the inductor must be large in size. A large inductor will
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https://en.wikipedia.org/wiki/Neural%20coding
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Neural coding (or neural representation) is a neuroscience field concerned with characterising the hypothetical relationship between the stimulus and the individual or ensemble neuronal responses and the relationship among the electrical activity of the neurons in the ensemble. Based on the theory that
sensory and other information is represented in the brain by networks of neurons, it is thought that neurons can encode both digital and analog information.
Overview
Neurons have an ability uncommon among the cells of the body to propagate signals rapidly over large distances by generating characteristic electrical pulses called action potentials: voltage spikes that can travel down axons. Sensory neurons change their activities by firing sequences of action potentials in various temporal patterns, with the presence of external sensory stimuli, such as light, sound, taste, smell and touch. Information about the stimulus is encoded in this pattern of action potentials and transmitted into and around the brain. Beyond this, specialized neurons, such as those of the retina, can communicate more information through graded potentials. This differs from action potentials because information about the strength of a stimulus directly correlates with the strength of the neurons output. The signal decays much faster for graded potentials, necessitating short inter-neuron distances and high neuronal density. The advantage of graded potentials are higher information rates capable of enco
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https://en.wikipedia.org/wiki/Alkaline%20lysis
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Alkaline lysis or alkaline extraction is a method used in molecular biology to isolate plasmid DNA from bacteria.
Method
Bacteria containing the plasmid of interest are first cultured, then a sample is centrifuged in order to concentrate cellular material (including DNA) into a pellet at the bottom of the containing vessel. The supernatant is discarded, and the pellet is then re-suspended in an EDTA-containing physiological buffer. The purpose of the EDTA is to chelate divalent metal cations such as Mg2+ and Ca2+, which are required for the function of DNA degrading enzymes (DNAses) and also serve to de-stabilise the DNA phosphate backbone and cell wall. Glucose in the buffer will maintain the osmotic pressure of the cell in order to prevent the cell from bursting. Tris in the buffer will retain the pH of the cell with 8.0 and RNase will remove the RNA which will disrupt the experiment.
Separately, a strong alkaline solution consisting of the detergent sodium dodecyl sulfate (SDS) and a strong base such as sodium hydroxide (NaOH) is prepared and then added. The resulting mixture is incubated for a few minutes. During this time, the detergent disrupts cell membranes and allows the alkali to contact and denature both chromosomal and plasmid DNA.
After tearing apart the cell membrane by SDS, the cell content will neutralize the NaOH; this is why the pH of the lysis goes down from 12.8 to 12.3. So if there are not enough bacterial cells, the extra NaOH will function to generate
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https://en.wikipedia.org/wiki/Myofibroblast
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A myofibroblast is a cell phenotype that was first described as being in a state between a fibroblast and a smooth muscle cell.
Structure
Myofibroblasts are contractile web-like fusiform cells that are identifiable by their expression of α-smooth muscle actin within their cytoplasmic stress fibers.
In the gastrointestinal and genitourinary tracts, myofibroblasts are found subepithelially in mucosal surfaces. Here they not only act as a regulator of the shape of the crypts and villi, but also act as stem-niche cells in the intestinal crypts and as parts of atypical antigen-presenting cells. They have both support as well as paracrine function in most places.
Location
Myofibroblasts were first identified in granulation tissue during skin wound healing. Typically, these cells are found in granulation tissue, scar tissue (fibrosis) and the stroma of tumours. They also line the gastrointestinal tract, wherein they regulate the shapes of crypts and villi.
Markers
Myofibroblasts usually stain for the intermediate filament vimentin, which is a general mesenchymal marker, α-smooth muscle actin (human gene = ACTA2), and for palladin, which is a cytoskeletal actin scaffold protein. They are positive for other smooth muscle markers, such as intermediate filament type desmin in some tissues, but may be negative for desmin in other tissues. Similar heterogeneous positivity may exist for almost every smooth muscle marker except probably a few which are positive only in contractile smo
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https://en.wikipedia.org/wiki/Hydroxybutyric%20acid
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Hydroxybutyric acid is a group of four-carbon organic compounds that have both hydroxyl and carboxylic acid functional groups. They can be viewed as derivatives of butyric acid. The carboxylate anion and the esters of hydroxybutyric acids are known as hydroxybutyrates. β-hydroxybutyric acid is relevant to human health as it is a member of a class of products of fatty acid oxidation referred to as ketone bodies.
The isomers are distinguished by the distance between the two functional groups and the branching.
alpha-Hydroxybutyric acid (2-hydroxybutyric acid)
beta-Hydroxybutyric acid (3-hydroxybutyric acid)
gamma-Hydroxybutyric acid (4-hydroxybutyric acid, GHB)
2-hydroxyisobutyric acid
3-hydroxyisobutyric acid
See also
beta-Hydroxy beta-methylbutyric acid
Sodium oxybate
References
External links
Hydroxy acids
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https://en.wikipedia.org/wiki/Softmax%20function
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The softmax function, also known as softargmax or normalized exponential function, converts a vector of real numbers into a probability distribution of possible outcomes. It is a generalization of the logistic function to multiple dimensions, and used in multinomial logistic regression. The softmax function is often used as the last activation function of a neural network to normalize the output of a network to a probability distribution over predicted output classes, based on Luce's choice axiom.
Definition
The softmax function takes as input a vector of real numbers, and normalizes it into a probability distribution consisting of probabilities proportional to the exponentials of the input numbers. That is, prior to applying softmax, some vector components could be negative, or greater than one; and might not sum to 1; but after applying softmax, each component will be in the interval , and the components will add up to 1, so that they can be interpreted as probabilities. Furthermore, the larger input components will correspond to larger probabilities.
The standard (unit) softmax function where is defined by the formula
In words, it applies the standard exponential function to each element of the input vector and normalizes these values by dividing by the sum of all these exponentials. The normalization ensures that the sum of the components of the output vector is 1. The term "softmax" derives from the amplifying effects of the exponential on any maxima in t
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https://en.wikipedia.org/wiki/Sani%20Flush
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Sani-Flush was an American brand of crystal toilet bowl cleaner formerly produced by Reckitt Benckiser. Its main ingredient was sodium bisulfate; it also contained sodium carbonate as well as sodium lauryl sulfate, talc, sodium chloride, fragrance and dye.
When sodium bisulfate is mixed with water, a highly-corrosive acidic solution is produced, which dissolves accumulated minerals such as iron, magnesium and calcium from the bowl.
Due to environmental concerns, the product has been discontinued; by 2013 its last original US trademark was cancelled or allowed to expire.
History
Sani-Flush was introduced by the Hygienic Products Company of Chicago, Illinois in 1911 as a toilet bowl cleaner; since 1922 it had also been promoted for flushing "rust, scale and sludge" from automobile radiators. Advertisements from the 1920s onward depicted a housewife in an apron using the product to disinfect the bowl and remove odours; it "cleans closet bowls without scouring" with "no drudgery whatsovever".
The brand was sold to American Home Products; that company's subsidiary Boyle-Midway was sold to Reckitt & Colman (now Reckitt Benckiser) in 1990. The primary direct competitor to Sani-Flush was Vanish, a brand of toilet cleaning crystals marketed in the US by Drackett, which was later acquired by the SC Johnson Company.
Widely stocked in grocery and hardware stores, the product was a well-known household name and occasionally mentioned in children's jokes like "If Santa gets stuck in
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https://en.wikipedia.org/wiki/Vitamin%20K%20epoxide%20reductase
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Vitamin K epoxide reductase (VKOR) is an enzyme () that reduces vitamin K after it has been oxidised in the carboxylation of glutamic acid residues in blood coagulation enzymes. VKOR is a member of a large family of predicted enzymes that are present in vertebrates, Drosophila, plants, bacteria and archaea. In some plant and bacterial homologues, the VKOR domain is fused with domains of the thioredoxin family of oxidoreductases.
Four cysteine residues and one residue, which is either serine or threonine, are identified as likely active-site residues. Solved bacterial VKOR structures has enabled more insights into the catalytic mechanism. All VKORs are transmembrane proteins with at least three TM helices at the catalytic core. The quinone to be reduced is bound by a redox-active CXXC motif in the C-terminal helices, similar to the DsbB active site. Two other cysteines to the N-terminal are located in a loop outside of the transmembrane region; they relay electrons with a redox protein (or in the case of the bacterial homolog, its own fused domain).
The human gene for VKOR is called VKORC1 (VKOR complex subunit 1). It is the target of anticoagulant warfarin. Its partner is a redox protein with an unknown identity, probably a thioredoxin-like protein located in the ER lumen such as TMX1.
There is also a similar gene called VKORC1L1. The VKORL1 complex it forms is much less efficient at reducing the epoxide, but it has the ability to reduce the quinone form of vitamin K to a
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https://en.wikipedia.org/wiki/Paternal%20mtDNA%20transmission
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In genetics, paternal mtDNA transmission and paternal mtDNA inheritance refer to the incidence of mitochondrial DNA (mtDNA) being passed from a father to his offspring. Paternal mtDNA inheritance is observed in a small proportion of species; in general, mtDNA is passed unchanged from a mother to her offspring, making it an example of non-Mendelian inheritance. In contrast, mtDNA transmission from both parents occurs regularly in certain bivalves.
In animals
Paternal mtDNA inheritance in animals varies. For example, in Mytilidae mussels, paternal mtDNA "is transmitted through the sperm and establishes itself only in the male gonad." In testing 172 sheep, "The Mitochondrial DNA from three lambs in two half-sib families were found to show paternal inheritance." An instance of paternal leakage resulted in a study on chickens. There has been evidences that paternal leakage is an integral part of mitochondrial inheritance of Drosophila simulans.
In humans
In human mitochondrial genetics, there is debate over whether or not paternal mtDNA transmission is possible. Many studies hold that paternal mtDNA is never transmitted to offspring. This thought is central to mtDNA genealogical DNA testing and to the theory of mitochondrial Eve. The fact that mitochondrial DNA is maternally inherited enables researchers to trace maternal lineage far back in time. Y chromosomal DNA, paternally inherited, is used in an analogous way to trace the agnate lineage.
In sexual reproduction, p
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https://en.wikipedia.org/wiki/Flow%20chemistry
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In flow chemistry, also called reactor engineering, a chemical reaction is run in a continuously flowing stream rather than in batch production. In other words, pumps move fluid into a reactor, and where tubes join one another, the fluids contact one another. If these fluids are reactive, a reaction takes place. Flow chemistry is a well-established technique for use at a large scale when manufacturing large quantities of a given material. However, the term has only been coined recently for its application on a laboratory scale by chemists and describes small pilot plants, and lab-scale continuous plants. Often, microreactors are used.
Batch vs. flow
Comparing parameter definitions in Batch vs Flow
Reaction stoichiometry: In batch production this is defined by the concentration of chemical reagents and their volumetric ratio. In flow this is defined by the concentration of reagents and the ratio of their flow rate.
Residence time: In batch production this is determined by how long a vessel is held at a given temperature. In flow the volumetric residence time is given by the ratio of the volume of the reactor and the overall flow rate, as most often, plug flow reactors are used.
Running flow reactions
Choosing to run a chemical reaction using flow chemistry, either in a microreactor or other mixing device offers a variety of pros and cons.
Advantages
Reaction temperature can be raised above the solvent's boiling point as the volume of the laboratory devices is typic
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https://en.wikipedia.org/wiki/List%20of%20genetic%20genealogy%20topics
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This is a list of genetic genealogy topics.
Important concepts
Genetic genealogy
Genealogical DNA test
Human mitochondrial DNA haplogroups
Human Y-chromosome DNA haplogroups
Allele
Allele frequency
Electropherogram
Genetic recombination
Haplogroup
Haplotype
* (haplogroup)
Most recent common ancestor
Short tandem repeat (STR)
Single nucleotide polymorphism (SNP)
Y-STR (Y-chromosome short tandem repeat)
Related fields
Archaeogenetics
Genealogy
Genetics
Genetic fingerprinting
DNA sequencing
Population genetics
Molecular genetics
Patrilineal relationships
Patrilineality
XY sex-determination system
Y-chromosomal Adam
Y-chromosomal Aaron
Adam's Curse
Paternal mtDNA transmission
RecLOH
Matrilineal relationships
Matrilineality
Mitochondrion
Mitochondrial DNA
Human mitochondrial genetics
Mitochondrial Eve
X chromosome
Biogeography, ethnicity and migration
Human migration
Population genetics
Multiregional hypothesis
Single-origin hypothesis
Projects
Human Genome Project
International HapMap Project
Molecular Genealogy Research Project
Surname DNA project
The Genographic Project
Lists
List of Y-chromosome databases
List of DNA tested mummies
List of DNA tested historical figures
List of genetic results derived from historical figures
Y-chromosome haplogroups in populations of the world
See also
List of genetics-related topics
Genetic genealogy
Genetic genealogy
Genetic genealogy topics
Genetic genealogy topics
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https://en.wikipedia.org/wiki/Pizotifen
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Pizotifen (INN) or pizotyline (USAN), trade name Sandomigran, is a benzocycloheptene-based drug used as a medicine, primarily as a preventive to reduce the frequency of recurrent migraine headaches.
Uses
The main medical use for pizotifen is for the prevention of migraine and cluster headache. Pizotifen is one of a range of medications used for this purpose, other options include propranolol, topiramate, valproic acid, cyproheptadine and amitriptyline. While pizotifen is effective in adults, evidence of efficacy in children is limited, and its use is limited by side effects, principally drowsiness and weight gain, and it is usually not the first choice medicine for preventing migraines, instead being used as an alternative when other drugs have failed to be effective. It is not effective in relieving migraine attacks once in progress. Pizotifen has also been reported as highly effective in a severe case of erythromelalgia, a rare neurovascular disease that is sometimes refractory to the other drugs named above.
Other applications for which pizotifen may be used include as an antidepressant, or for the treatment of anxiety or social phobia. Animal studies also suggest that pizotyline could be used in the treatment of serotonin syndrome or MDMA overdose in a similar manner to the closely related antihistamine/antiserotonin medication cyproheptadine.
Adverse effects
Side effects include sedation, dry mouth, drowsiness, increased appetite and weight gain. Occasionally it may
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https://en.wikipedia.org/wiki/Transterm
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Transterm is a database of mRNA sequences, codon usage, and associated cis-regulatory elements that regulate gene expression. Many of these elements are in the 3' UTR. Transterm is a database provided by the Biochemistry department of The University of Otago. Transterm is used to look at the protein binding sites within mRNA. Transterm is continually updated based upon results in peer-reviewed journals.
References
External links
Transterm database online
Biological databases
Biology websites
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https://en.wikipedia.org/wiki/Position-effect%20variegation
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Position-effect variegation (PEV) is a variegation caused by the silencing of a gene in some cells through its abnormal juxtaposition with heterochromatin via rearrangement or transposition. It is also associated with changes in chromatin conformation.
Overview
The classical example is the Drosophila wm4 (speak white-mottled-4) translocation. In this mutation, an inversion on the X chromosome placed the white gene next to pericentric heterochromatin, or a sequence of repeats that becomes heterochromatic. Normally, the white gene is expressed in every cell of the adult Drosophila eye resulting in a red-eye phenotype. In the w[m4] mutant, the eye color was variegated (red-white mosaic colored) where the white gene was expressed in some cells in the eyes and not in others. The mutation was described first by Hermann Muller in 1930. PEV is a heterochromatin-induced gene inactivation. Gene silencing phenomena similar to this have also been observed in S. cerevisiae and S. pombe.
Typically, the barrier DNA sequences prevent the heterochromatic region from spreading into the euchromatin but they are no longer present in the flies that inherit certain chromosomal rearrangements.
Etymology
PEV is a position effect because the change in position of a gene from its original position to somewhere near a heterochromatic region has an effect on its expression. The effect is the variegation in a particular phenotype i.e., the appearance of irregular patches of different colour(s), du
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https://en.wikipedia.org/wiki/G%C3%BCrkan%20Sermeter
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Gürkan Sermeter (born 14 February 1974) is a Swiss former footballer who last played for AC Bellinzona in the Swiss Challenge League.
External links
Statistics at T-Online.de
AC Bellinzona profile
1974 births
Swiss men's footballers
Living people
FC Aarau players
Grasshopper Club Zürich players
BSC Young Boys players
FC Luzern players
AC Bellinzona players
Swiss Super League players
Swiss Challenge League players
Men's association football midfielders
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https://en.wikipedia.org/wiki/Cake%20hole
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Cake Hole may refer to:
As a crude phrase, the mouth
In music
Cakehole, a song by The Crystal Method on their Community Service album
A remix by Evil Nine for Distinct'ive Records' Y4K series on the ILS Presents: Y4K album.
"Cakewhole", a remix by Ferocious Mullet for Distinct'ive Records' Y4K series on the Überzone Presents: Y4K album.
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https://en.wikipedia.org/wiki/Cyanovirin-N
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Cyanovirin-N (CV-N) is a protein produced by the cyanobacterium Nostoc ellipsosporum that displays virucidal activity against several viruses, including human immunodeficiency virus (HIV). A cyanobacterial protein called cyanovirin-N (CV-N) has strong anti-human immunodeficiency virus (HIV) neutralizing properties. The virucidal activity of CV-N is mediated through specific high-affinity interactions with the viral surface envelope glycoproteins gp120 and gp41, as well as to high-mannose oligosaccharides found on the HIV envelope. In addition, CV-N is active against rhinoviruses, human parainfluenza virus, respiratory syncytial virus, and enteric viruses. The virucidal activity of CV-N against influenza virus is directed towards viral haemagglutinin.
The blue-green alga Nostoc ellipsosporum naturally contains the protein cyanovirin-N. The National Cancer Institute (NCI) in the United States carried out the initial isolation and characterisation of this protein in 1999. The use of cyanovirin-N as an antiviral drug, particularly against HIV, has since been the subject of investigation. Its ability to bind to the HIV-encapsulating glycoprotein gp120 has been demonstrated in several studies, which has led to the development of Cyanovirin-N-based therapies and preventatives.
Structure
Cyanovirin-N is a lengthy, mostly beta-sheet protein that displays internal two-fold pseudosymmetry. The fundamental atomic root-mean-square of the two sequence repeats (1-50 and 51-101) differs
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https://en.wikipedia.org/wiki/Indexed%20search
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Indexed search, also called the cutpoint method, is an algorithm for discrete-distribution pseudo-random number sampling, invented by Chen and Asau in 1974.
References
Sources
Fishman,G.S. (1996) Monte Carlo. Concepts, Algorithms, and Applications. New York: Springer.
Ripley, B. D. (1987) Stochastic Simulation. Wiley.
Non-uniform random numbers
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https://en.wikipedia.org/wiki/Algorithmic%20Number%20Theory%20Symposium
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Algorithmic Number Theory Symposium (ANTS) is a biennial academic conference, first held in Cornell in 1994, constituting an international forum for the presentation of new research in computational number theory. They are devoted to algorithmic aspects of number theory, including elementary number theory, algebraic number theory, analytic number theory, geometry of numbers, arithmetic geometry, finite fields, and cryptography.
Selfridge Prize
In honour of the many contributions of John Selfridge to mathematics, the Number Theory Foundation has established a prize to be awarded to those individuals who have authored the best paper accepted for presentation at ANTS. The prize, called the Selfridge Prize, is awarded every two years in an even numbered year. The prize winner(s) receive a cash award and a sculpture.
The prize winners and their papers selected by the ANTS Program Committee are:
2006 – ANTS VII – Werner Bley and Robert Boltje – Computation of locally free class groups.
2008 – ANTS VIII – Juliana Belding, Reinier Bröker, Andreas Enge and Kristin Lauter – Computing hilbert class polynomials.
2010 – ANTS IX – John Voight – Computing automorphic forms on Shimura curves over fields with arbitrary class number.
2012 – ANTS X – Andrew Sutherland – On the evaluation of modular polynomials.
2014 – ANTS XI – Tom Fisher – Minimal models for 6-coverings of elliptic curves.
2016 – ANTS XII – Jan Steffen Müller and Michael Stoll – Computing canonical heights on
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https://en.wikipedia.org/wiki/Micro%20heat%20exchanger
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Micro heat exchangers, Micro-scale heat exchangers, or microstructured heat exchangers are heat exchangers in which (at least one) fluid flows in lateral confinements with typical dimensions below 1 mm. The most typical such confinement are microchannels, which are channels with a hydraulic diameter below 1 mm. Microchannel heat exchangers can be made from metal or ceramic.
Microchannel heat exchangers can be used for many applications including:
high-performance aircraft gas turbine engines
heat pumps
Microprocessor and microchip cooling
air conditioning
Background
Investigation of microscale thermal devices is motivated by the single phase internal flow correlation for convective heat transfer:
Where is the heat transfer coefficient, is the Nusselt number, is the thermal conductivity of the fluid and is the hydraulic diameter of the channel or duct. In internal laminar flows, the Nusselt number becomes a constant. This is a result which can be arrived at analytically: For the case of a constant wall temperature, and for the case of constant heat flux for round tubes. The last value is increased to 140/17 = 8.23 for flat parallel plates. As Reynolds number is proportional to hydraulic diameter, fluid flow in channels of small hydraulic diameter will predominantly be laminar in character. This correlation therefore indicates that the heat transfer coefficient increases as channel diameter decreases. Should the hydraulic diameter in forced convection be on the o
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https://en.wikipedia.org/wiki/List%20of%20Sheffield%20Wednesday%20F.C.%20records%20and%20statistics
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These are Sheffield Wednesday F.C. records. They cover all competitive matches dating back to the team's first appearance in the FA Cup in 1880.
Record Games
Seasonal records
Record Runs
All records relate to league games only
Players
General
Transfers
Appearances and goals
Highest Average attendance in a season
Honours
Top tier
Lower tier
Local
References
Club records (last accessed 28 July 2006)
Appearances (last accessed 28 July 2006)
Goalscorers (last accessed 28 July 2006)
Honours (last archived 15 October 2012)
Club Records (last accessed 1 September 2016)
Record Signing (last accessed 1 September 2016)
Records
Sheffield Wednesday
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https://en.wikipedia.org/wiki/Conversion%20rate%20optimization
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Conversion rate optimization (CRO) is the process of increasing the percentage of users or website visitors to take a desired action (such as buying a product or leaving contact details).
History
Online conversion rate optimization (or website optimization) was born out of the need of e-commerce marketers to improve their website's performance in the aftermath of the dot-com bubble, when technology companies started to be more aware about their spending, investing more in website analytics. After the burst, with website creation being more accessible, tons of pages with bad user experience were created. As competition grew on the web during the early 2000s, website analysis tools became available, and awareness of website usability grew, internet marketers were prompted to produce measurables for their tactics and improve their website's user experience.
In 2004, new tools enabled internet marketers to experiment with website design and content variations to determine which layouts, copy text, offers, and images perform best. Testing started to be more accessible and known. This form of optimization accelerated in 2007 with the introduction of the free tool Google Website Optimizer. Today, optimization and conversion are key aspects of many digital marketing campaigns. A research study conducted among internet marketers in 2017, for example, showed that 50% of respondents thought that CRO was "crucial to their overall digital marketing strategy".
Conversion rate optimizat
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https://en.wikipedia.org/wiki/Somebody%20Loves%20You
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Somebody Loves You may refer to:
Somebody Loves You (album), a 1975 album by Crystal Gayle
"Somebody Loves You" (Crystal Gayle song), the album's title track
"Somebody Loves You" (1932 song), by Peter deRose and Charles Tobias
"Somebody Loves You" (Nik Kershaw song), 1999
"Somebody Loves You" (Betty Who song), 2012
"Somebody Loves You Baby (You Know Who It Is)", a 1991 song by Patti LaBelle
Somebody Loves You, a 2009 album by Austin Lucas
"Somebody Loves You", a song by The Delfonics from Sound of Sexy Soul
"Somebody Loves You", a song by Eels from Shootenanny!
"Somebody (Loves You)", a song by Plies from Definition of Real
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https://en.wikipedia.org/wiki/Electrosynthesis
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In electrochemistry, electrosynthesis is the synthesis of chemical compounds in an electrochemical cell. Compared to ordinary redox reactions, electrosynthesis sometimes offers improved selectivity and yields. Electrosynthesis is actively studied as a science and also has industrial applications. Electrooxidation has potential for wastewater treatment as well.
Experimental setup
The basic setup in electrosynthesis is a galvanic cell, a potentiostat and two electrodes. Typical solvent and electrolyte combinations minimizes electrical resistance. Protic conditions often use alcohol-water or dioxane-water solvent mixtures with an electrolyte such as a soluble salt, acid or base. Aprotic conditions often use an organic solvent such as acetonitrile or dichloromethane with electrolytes such as lithium perchlorate or tetrabutylammonium salts. The choice of electrodes with respect to their composition and surface area can be decisive. For example, in aqueous conditions the competing reactions in the cell are the formation of oxygen at the anode and hydrogen at the cathode. In this case a graphite anode and lead cathode could be used effectively because of their high overpotentials for oxygen and hydrogen formation respectively. Many other materials can be used as electrodes. Other examples include platinum, magnesium, mercury (as a liquid pool in the reactor), stainless steel or reticulated vitreous carbon. Some reactions use a sacrificial electrode that is consumed during the react
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https://en.wikipedia.org/wiki/Pollination%20syndrome
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Pollination syndromes are suites of flower traits that have evolved in response to natural selection imposed by different pollen vectors, which can be abiotic (wind and water) or biotic, such as birds, bees, flies, and so forth through a process called pollinator-mediated selection. These traits include flower shape, size, colour, odour, reward type and amount, nectar composition, timing of flowering, etc. For example, tubular red flowers with copious nectar often attract birds; foul smelling flowers attract carrion flies or beetles, etc.
The "classical" pollination syndromes were first studied in the 19th century by the Italian botanist Federico Delpino. Although they are useful in understanding of plant-pollinator interactions, sometimes the pollinator of a plant species cannot be accurately predicted from the pollination syndrome alone, and caution must be exerted in making assumptions.
The naturalist Charles Darwin surmised that the flower of the orchid Angraecum sesquipedale was pollinated by a then undiscovered moth with a proboscis whose length was unprecedented at the time. His prediction had gone unverified until 21 years after his death, when the moth was discovered and his conjecture vindicated. The story of its postulated pollinator has come to be seen as one of the celebrated predictions of the theory of evolution.
Abiotic
These do not attract animal pollinators. Nevertheless, they often have suites of shared traits.
Wind pollination (anemophily)
Flowers ma
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https://en.wikipedia.org/wiki/Poisson%E2%80%93Boltzmann%20equation
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The Poisson–Boltzmann equation is a useful equation in many settings, whether it be to understand physiological interfaces, polymer science, electron interactions in a semiconductor, or more. It aims to describe the distribution of the electric potential in solution in the direction normal to a charged surface. This distribution is important to determine how the electrostatic interactions will affect the molecules in solution. The Poisson–Boltzmann equation is derived via mean-field assumptions.
From the Poisson–Boltzmann equation many other equations have been derived with a number of different assumptions.
Origins
Background and derivation
The Poisson–Boltzmann equation describes a model proposed independently by Louis Georges Gouy and David Leonard Chapman in 1910 and 1913, respectively. In the Gouy-Chapman model, a charged solid comes into contact with an ionic solution, creating a layer of surface charges and counter-ions or double layer. Due to thermal motion of ions, the layer of counter-ions is a diffuse layer and is more extended than a single molecular layer, as previously proposed by Hermann Helmholtz in the Helmholtz model. The Stern Layer model goes a step further and takes into account the finite ion size.
The Gouy–Chapman model explains the capacitance-like qualities of the electric double layer. A simple planar case with a negatively charged surface can be seen in the figure below. As expected, the concentration of counter-ions is higher near the surface
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https://en.wikipedia.org/wiki/Hugo%20Morales
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Hugo Alberto Morales (born 30 July 1974 in Buenos Aires) is an Argentine retired footballer who played as a midfielder.
External links
Argentine League statistics
1974 births
Living people
Footballers from Buenos Aires
Argentine men's footballers
Men's association football midfielders
Argentine Primera División players
Club Atlético Huracán footballers
Club Atlético Independiente footballers
Club Atlético Lanús footballers
Talleres de Córdoba footballers
La Liga players
Segunda División players
CD Tenerife players
Categoría Primera A players
Atlético Nacional footballers
Millonarios F.C. players
Club Deportivo Universidad Católica footballers
Argentina men's youth international footballers
Argentina men's under-20 international footballers
Argentina men's international footballers
Footballers at the 1996 Summer Olympics
Olympic footballers for Argentina
Olympic silver medalists for Argentina
Olympic medalists in football
Argentine expatriate men's footballers
Argentine expatriate sportspeople in Spain
Expatriate men's footballers in Spain
Expatriate men's footballers in Colombia
Expatriate men's footballers in Chile
Medalists at the 1996 Summer Olympics
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https://en.wikipedia.org/wiki/Dentigerous%20cyst
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A dentigerous cyst, also known as a follicular cyst, is an epithelial-lined developmental cyst formed by accumulation of fluid between the reduced enamel epithelium and the crown of an unerupted tooth. It is formed when there is an alteration in the reduced enamel epithelium and encloses the crown of an unerupted tooth at the cemento-enamel junction. Fluid is accumulated between reduced enamel epithelium and the crown of an unerupted tooth.
Dentigerous cysts are the second most prevalent type of odontogenic cysts after radicular cyst. Seventy percent of the cases occur in the mandible. Dentigerous cysts are usually painless. The patient usually comes with a concern of delayed tooth eruption or facial swelling. A dentigerous cyst can go unnoticed and may be discovered coincidentally on a regular radiographic examination.
Pathogenesis
Odontogenesis happens by means of a complex interaction between oral epithelium and surrounding mesenchymal tissue. Abnormal tissue interaction during this process can result in ectopic tooth development. Ectopic tooth eruption may result due to pathological process, such as a tumor or cyst or developmental disturbance. The pathogenesis of dentigerous cyst is still controversial.
The accumulation of fluid either between the reduced enamel epithelium and enamel or in between the layers of enamel organ seems to be the key to the formation of dentigerous cysts.
A potentially erupting tooth on an impacted follicle can obstruct the venous outflow,
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https://en.wikipedia.org/wiki/Fredrik%20Lindstr%C3%B6m%20%28writer%29
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Fredrik Lindström (born 27 June 1963 in Eskilstuna, Södermanland County) is a Swedish comedian, film director and presenter.
He played drums for the heavy metal band CRYSTAL PRIDE in the early 1980s.
In the 2000s, Lindström became a household name in Sweden through his documentary series Värsta språket about the Swedish language at Sveriges Television. Lindström has written several books that served as a basis for the series as well as historic linguistics in the Swedish language. They have the same kind of approach, mixing informality with information derived from the author's linguistics background.
Lindström's first encounter with the Swedish audience was on the radio show Hassan, on which he made prank calls to random people pretending to be different imaginary people, often with some kind of subtle disturbance that made the conversation farcical. The show aired on P3 for several seasons in the 1990s.
Since 2010, he has taken Björn Hellberg's role as the referee, in one of the most popular Television-Quizzes in Sweden ever, På spåret, which largely is a contest in geography, but also includes history, linguistics, sports and various subjects.
A few years later, after various smaller appearances as a stand-up comedian, he directed two Swedish featured films in the comedy/drama genre; these featured well-known Swedish actors such as Mikael Persbrandt and Magnus Härenstam.
Discography
Films
Vuxna människor, 1999 (Adult Behaviour, lit. Adult People.)
Känd från TV, 20
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https://en.wikipedia.org/wiki/Anisindione
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Anisindione (brand name Miradon) is a synthetic anticoagulant and an 1,3-indandione derivative. It prevents the formation of active procoagulation factors II, VII, IX, and X, as well as the anticoagulant proteins C and S, in the liver by inhibiting the vitamin K–mediated gamma-carboxylation of precursor proteins.
References
Anticoagulants
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https://en.wikipedia.org/wiki/Well-known%20text%20representation%20of%20geometry
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Well-known text (WKT) is a text markup language for representing vector geometry objects. A binary equivalent, known as well-known binary (WKB), is used to transfer and store the same information in a more compact form convenient for computer processing but that is not human-readable. The formats were originally defined by the Open Geospatial Consortium (OGC) and described in their Simple Feature Access. The current standard definition is in the ISO/IEC 13249-3:2016 standard.
Geometric objects
WKT can represent the following distinct geometric objects:
Point, MultiPoint
LineString, MultiLineString
Polygon, MultiPolygon, Triangle
PolyhedralSurface
TIN (Triangulated irregular network)
GeometryCollection
Coordinates for geometries may be 2D (x, y), 3D (x, y, z), 4D (x, y, z, m) with an m value that is part of a linear referencing system or 2D with an m value (x, y, m). Three-dimensional geometries are designated by a "Z" after the geometry type and geometries with a linear referencing system have an "M" after the geometry type. Empty geometries that contain no coordinates can be specified by using the symbol EMPTY after the type name.
WKT geometries are used throughout OGC specifications and are present in applications that implement these specifications. For example, PostGIS contains functions that can convert geometries to and from a WKT representation, making them human readable.
The OGC standard definition requires a polygon to be topologically closed. It also states t
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https://en.wikipedia.org/wiki/Division%20No.%201%2C%20Saskatchewan
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Division No. 1 is one of eighteen census divisions in the province of Saskatchewan, Canada, as defined by Statistics Canada. It is located in the southeast corner of the province, bordering Manitoba and North Dakota. The most populous community in this division is Estevan.
Demographics
In the 2021 Census of Population conducted by Statistics Canada, Division No. 1 had a population of living in of its total private dwellings, a change of from its 2016 population of . With a land area of , it had a population density of in 2021.
Census subdivisions
The following census subdivisions (municipalities or municipal equivalents) are located within Saskatchewan's Division No. 1.
Cities
Estevan
Towns
Alameda
Arcola
Bienfait
Carlyle
Carnduff
Lampman
Oxbow
Redvers
Stoughton
Wawota
Villages
Alida
Carievale
Fairlight
Forget
Frobisher
Gainsborough
Glen Ewen
Heward
Kennedy
Kenosee Lake
Kisbey
Manor
Maryfield
North Portal
Roche Percee
Storthoaks
Rural municipalities
RM No. 1 Argyle
RM No. 2 Mount Pleasant
RM No. 3 Enniskillen
RM No. 4 Coalfields
RM No. 5 Estevan
RM No. 31 Storthoaks
RM No. 32 Reciprocity
RM No. 33 Moose Creek
RM No. 34 Browning
RM No. 35 Benson
RM No. 61 Antler
RM No. 63 Moose Mountain
RM No. 64 Brock
RM No. 65 Tecumseh
RM No. 91 Maryfield
RM No. 92 Walpole
RM No. 93 Wawken
RM No. 94 Hazelwood
RM No. 95 Golden West
Indian reserves
Ocean Man First Nation
Ocean Man 69
Ocean Man 69A
Ocean Man 69B
Ocean Man 69C
Ocean Man 69E
Ocean Man 69F
Ocean Man 69G
O
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https://en.wikipedia.org/wiki/Division%20No.%203%2C%20Saskatchewan
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Division No. 3 is one of eighteen census divisions in the province of Saskatchewan, Canada, as defined by Statistics Canada. It is located in the south-southwestern part of the province, adjacent to the border with Montana, United States. The most populous community in this division is Assiniboia.
Demographics
In the 2021 Census of Population conducted by Statistics Canada, Division No. 3 had a population of living in of its total private dwellings, a change of from its 2016 population of . With a land area of , it had a population density of in 2021.
Census subdivisions
The following census subdivisions (municipalities or municipal equivalents) are located within Saskatchewan's Division No. 3.
Towns
Assiniboia
Coronach
Gravelbourg
Mossbank
Ponteix
Rockglen
Willow Bunch
Villages
Hazenmore
Kincaid
Limerick
Mankota
Neville
Vanguard
Wood Mountain
Rural municipalities
RM No. 11 Hart Butte
RM No. 12 Poplar Valley
RM No. 42 Willow Bunch
RM No. 43 Old Post
RM No. 44 Waverley
RM No. 45 Mankota
RM No. 46 Glen McPherson
RM No. 71 Excel
RM No. 72 Lake of the Rivers
RM No. 73 Stonehenge
RM No. 74 Wood River
RM No. 75 Pinto Creek
RM No. 76 Auvergne
RM No. 101 Terrell
RM No. 102 Lake Johnston
RM No. 103 Sutton
RM No. 104 Gravelbourg
RM No. 105 Glen Bain
RM No. 106 Whiska Creek
Indian reserves
Cowessess First Nation
Cowessess 73
Sturgeon Lake First Nation
Sturgeon Lake 101C
Wood Mountain Lakota First Nation
Wood Mountain 160
Other communities
Aneroid
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https://en.wikipedia.org/wiki/Division%20No.%204%2C%20Saskatchewan
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Division No. 4 is one of eighteen census divisions in the province of Saskatchewan, Canada, as defined by Statistics Canada. It is located in the southwest corner of the province, bordering Alberta to the west and Montana, United States to the south. The most populous community in this division is Maple Creek.
Demographics
In the 2021 Census of Population conducted by Statistics Canada, Division No. 4 had a population of living in of its total private dwellings, a change of from its 2016 population of . With a land area of , it had a population density of in 2021.
Census subdivisions
The following census subdivisions (municipalities or municipal equivalents) are located within Saskatchewan's Division No. 4.
Towns
Eastend
Maple Creek
Shaunavon
Villages
Bracken
Cadillac
Carmichael
Climax
Consul
Frontier
Neville
Val Marie
Rural municipalities
RM No. 17 Val Marie
RM No. 18 Lone Tree
RM No. 19 Frontier
RM No. 49 White Valley
RM No. 51 Reno
RM No. 77 Wise Creek
RM No. 78 Grassy Creek
RM No. 79 Arlington
RM No. 107 Lac Pelletier
RM No. 108 Bone Creek
RM No. 109 Carmichael
RM No. 110 Piapot
RM No. 111 Maple Creek
Other communities
Special service areas
Admiral
Organized hamlets
Darlings Beach
Hamlets
Orkney
Piapot
Simmie
Unincorporated communities
Battle Creek
Beaver Valley
Belanger
Blumenort
Canuck
Carnagh
Claydon
Cross
Cummings
Divide
Dollard
East Fairwell
Edgell
Fort Walsh, National historic site
Garden Head
Govenlock
Hatton
Hillan
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https://en.wikipedia.org/wiki/Umbo
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Umbo may refer to:
Anatomy
Umbo (eye), tiny depression in the center of the foveola corresponding to the foveal reflex
Umbo of tympanic membrane, the central, most inverted portion of the eardrum
Flora and fauna
Umbo (bivalve), part of a bivalve shell which was formed when the animal was a juvenile
Umbo (conifer cone), the first year's growth of a seed scale on a conifer cone, showing up as a protuberance at the end of the two-year-old scale
Umbo (mycology), at the top of some mushrooms
Other
Otto Umbehr (1902–1980), a German photographer known as "Umbo"
A shield boss, a round, convex, or conical piece of material at the center of a shield
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https://en.wikipedia.org/wiki/Tenon%27s%20capsule
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Tenon's capsule (), also known as the Tenon capsule, fascial sheath of the eyeball () or the fascia bulbi, is a thin membrane which envelops the eyeball from the optic nerve to the corneal limbus, separating it from the orbital fat and forming a socket in which it moves.
The inner surface of Tenon's capsule is smooth and is separated from the outer surface of the sclera by the periscleral lymph space. This lymph space is continuous with the subdural and subarachnoid cavities and is traversed by delicate bands of connective tissue which extend between the capsule and the sclera.
The capsule is perforated behind by the ciliary vessels and nerves and fuses with the sheath of the optic nerve and with the sclera around the entrance of the optic nerve. In front it adheres to the conjunctiva, and both structures are attached to the ciliary region of the eyeball.
The structure was named after Jacques-René Tenon (1724–1816), a French surgeon and pathologist.
Structure
Relations
Tenon's capsule is perforated by the tendons of the ocular muscles and is reflected backward on each as a tubular sheath. The sheath of the obliquus superior is carried as far as the fibrous pulley of that muscle, and that on the obliquus inferior reaches as far as the floor of the orbit, to which it gives off a slip. The sheaths on the recti muscles are gradually lost in the perimysium, but they give off important expansions. The expansion from the rectus superior blends with the tendon of the levator pal
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https://en.wikipedia.org/wiki/Downhill%20Racer
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Downhill Racer is a 1969 American sports drama film starring Robert Redford, Gene Hackman and Camilla Sparv, and was the directorial debut of Michael Ritchie. Written by James Salter, based on the 1963 novel The Downhill Racers by Oakley Hall, the film is about a talented downhill skier who joins the United States Ski Team in Europe to compete in international skiing competitions.
Downhill Racer was filmed on location in Kitzbühel and Sankt Anton am Arlberg in Austria, Wengen in Switzerland, Megève and Grenoble in France and Boulder and Idaho Springs in Colorado, United States. The film received positive reviews upon its theatrical release; Roger Ebert called it "the best movie ever made about sports—without really being about sports at all."
Plot
American downhill skier David Chappellet arrives in Wengen, Switzerland to join the U.S. ski team along with fellow newcomer D. K. Bryan. Both men were summoned by team coach Eugene Claire to replace Tommy Herb, one of his top skiers, who was recently injured during an FIS competition. Raised in the small town of Idaho Springs, Colorado, Chappellet is a loner focused only on becoming a skiing champion, and shows little interest in being a team player. After refusing to race at the Lauberhorn because of a late starting position, he makes his European skiing debut at the Arlberg-Kandahar in Austria, where he finishes in an impressive fourth position. In the final race of the season at the Hahnenkamm-Rennen in Kitzbühel, Austria, he
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https://en.wikipedia.org/wiki/Sirna
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Sirna may refer to:
Sírna, legendary High King of Ireland
Șirna, a commune in Prahova County, Romania
Sirna, Iran, a village in Markazi Province, Iran
Small interfering RNA (siRNA)
Syrna, also spelled Sirna, Greek village
Syrna (island), also spelled Sirna, Greek island
Sirna Therapeutics
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https://en.wikipedia.org/wiki/BasicX
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BasicX is a free programming language designed specifically for NetMedia's BX-24 microcontroller and based on the BASIC programming language. It is used in the design of robotics projects such as the Robodyssey Systems Mouse robot.
Further reading
Odom, Chris D. BasicX and Robotics. Robodyssey Systems LLC,
External links
NetMedia Home Page
BasicX Free Downloads
Sample Code
, programmed in BasicX
Videos, Sample Code, and Tutorials from the author of BasicX and Robotics
BASIC compilers
Embedded systems
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https://en.wikipedia.org/wiki/Interleukin-3%20receptor
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The interleukin-3 receptor (CD123) is a molecule found on cells which helps transmit the signal of interleukin-3, a soluble cytokine important in the immune system.
The gene coding for the receptor is located in the pseudoautosomal region of the X and Y chromosomes.
The receptor belongs to the type I cytokine receptor family and is a heterodimer with a unique alpha chain paired with the common beta (beta c or CD131) subunit.
The gene for the alpha subunit is 40 kilobases long and has 12 exons.
Cell types and function
The receptor, found on pluripotent progenitor cells, induces tyrosine phosphorylation within the cell and promotes proliferation and differentiation within the hematopoietic cell lines. It can be found on basophils and pDCs as well as some cDCs among peripheral blood mononuclear cells.
CD123 is expressed across acute myeloid leukemia (AML) subtypes, including leukemic stem cells.
Possible drug target
Tagraxofusp, human IL-3 fused to diphtheria toxin, is an approved treatment for BPDCN.
An experimental antibody-drug conjugate SGN-CD123A targets CD123 as a possible treatment for AML.
References
External links
Type I cytokine receptors
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https://en.wikipedia.org/wiki/Division%20No.%205%2C%20Saskatchewan
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Division No. 5 is one of eighteen census divisions in the province of Saskatchewan, Canada, as defined by Statistics Canada. It is located in the east-southeastern part of the province, bordering Manitoba. The most populous community in this division is Melville.
Demographics
In the 2021 Census of Population conducted by Statistics Canada, Division No. 5 had a population of living in of its total private dwellings, a change of from its 2016 population of . With a land area of , it had a population density of in 2021.
Census subdivisions
The following census subdivisions (municipalities or municipal equivalents) are located within Saskatchewan's Division No. 5.
Cities
Melville
Towns
Bredenbury
Broadview
Churchbridge
Esterhazy
Fleming
Grenfell
Kipling
Langenburg
Lemberg
Moosomin
Rocanville
Saltcoats
Wapella
Whitewood
Wolseley
Villages
Atwater
Bangor
Dubuc
Duff
Fenwood
Gerald
Glenavon
Goodeve
Grayson
Killaly
MacNutt
Neudorf
Spy Hill
Stockholm
Tantallon
Waldron
Welwyn
Windthorst
Yarbo
Resort villages
Bird's Point
Melville Beach
West End
Rural municipalities
RM No. 121 Moosomin
RM No. 122 Martin
RM No. 123 Silverwood
RM No. 124 Kingsley
RM No. 125 Chester
RM No. 151 Rocanville
RM No. 152 Spy Hill
RM No. 153 Willowdale
RM No. 154 Elcapo
RM No. 155 Wolseley
RM No. 181 Langenburg
RM No. 183 Fertile Belt
RM No. 184 Grayson
RM No. 185 McLeod
RM No. 211 Churchbridge
RM No. 213 Saltcoats
RM No. 214 Cana
RM No. 215 Stanley
Indian reserves
Cowessess Fir
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https://en.wikipedia.org/wiki/Division%20No.%206%2C%20Saskatchewan
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Division No. 6 is one of eighteen census divisions in the province of Saskatchewan, Canada, as defined by Statistics Canada. It is located in the south-central part of the province. The most populous community in this division is Regina, the provincial capital.
Demographics
In the 2021 Census of Population conducted by Statistics Canada, Division No. 6 had a population of living in of its total private dwellings, a change of from its 2016 population of . With a land area of , it had a population density of in 2021.
Census subdivisions
The following census subdivisions (municipalities or municipal equivalents) are located within Saskatchewan's Division No. 6.
Cities
Regina
Towns
Balcarres
Balgonie
Cupar
Fort Qu'Appelle
Francis
Grand Coulee
Indian Head
Lumsden
Pilot Butte
Qu'Appelle
Regina Beach
Rouleau
Sintaluta
Southey
Strasbourg
White City
Villages
Abernethy
Belle Plaine
Bethune
Briercrest
Buena Vista
Bulyea
Chamberlain
Craven
Dilke
Disley
Drinkwater
Dysart
Earl Grey
Edenwold
Findlater
Holdfast
Kendal
Lebret
Lipton
Markinch
McLean
Montmartre
Odessa
Pense
Sedley
Silton
Vibank
Wilcox
Resort villages
Alice Beach
B-Say-Tah
Fort San
Glen Harbour
Grandview Beach
Island View
Kannata Valley
Katepwa
Lumsden Beach
North Grove
Pelican Pointe
Saskatchewan Beach
Sunset Cove
Wee Too Beach
Rural municipalities
RM No. 126 Montmartre
RM No. 127 Francis
RM No. 128 Lajord
RM No. 129 Bratt's Lake
RM No. 130 Redburn
RM No. 156 Indian Head
RM No. 157 South Qu'Appelle
RM N
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https://en.wikipedia.org/wiki/Division%20No.%207%2C%20Saskatchewan
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Division No. 7 is one of eighteen census divisions in the province of Saskatchewan, Canada, as defined by Statistics Canada. It is located in the south-central part of the province. The most populous community in this division is Moose Jaw.
Demographics
In the 2021 Census of Population conducted by Statistics Canada, Division No. 7 had a population of living in of its total private dwellings, a change of from its 2016 population of . With a land area of , it had a population density of in 2021.
Census subdivisions
The following census subdivisions (municipalities or municipal equivalents) are located within Saskatchewan's Division No. 7.
Cities
Moose Jaw
Towns
Central Butte
Craik
Herbert
Morse
Villages
Aylesbury
Beechy
Brownlee
Caronport
Chaplin
Coderre
Ernfold
Eyebrow
Hodgeville
Keeler
Lucky Lake
Marquis
Mortlach
Riverhurst
Rush Lake
Shamrock
Tugaske
Tuxford
Waldeck
Resort villages
Beaver Flat
Coteau Beach
Mistusinne
South Lake
Sun Valley
Rural municipalities
RM No. 131 Baildon
RM No. 132 Hillsborough
RM No. 133 Rodgers
RM No. 134 Shamrock
RM No. 135 Lawtonia
RM No. 136 Coulee
RM No. 161 Moose Jaw
RM No. 162 Caron
RM No. 163 Wheatlands
RM No. 164 Chaplin
RM No. 165 Morse
RM No. 166 Excelsior
RM No. 191 Marquis
RM No. 193 Eyebrow
RM No. 194 Enfield
RM No. 222 Craik
RM No. 223 Huron
RM No. 224 Maple Bush
RM No. 225 Canaan
RM No. 226 Victory
RM No. 255 Coteau
RM No. 256 King George
Other communities
Hamlets
Bateman
Birsay
Bushell Park
Car
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https://en.wikipedia.org/wiki/Division%20No.%208%2C%20Saskatchewan
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Division No. 8 is one of eighteen census divisions in the province of Saskatchewan, Canada, as defined by Statistics Canada. It is located in the west-southwestern part of the province, bordering Alberta. The most populous community in this division is Swift Current.
Demographics
In the 2021 Census of Population conducted by Statistics Canada, Division No. 8 had a population of living in of its total private dwellings, a change of from its 2016 population of . With a land area of , it had a population density of in 2021.
Census subdivisions
The following census subdivisions (municipalities or municipal equivalents) are located within Saskatchewan's Division No. 8.
Cities
Swift Current
Towns
Burstall
Cabri
Eatonia
Elrose
Eston
Gull Lake
Kyle
Leader
Villages
Abbey
Fox Valley
Golden Prairie
Hazlet
Lancer
Mendham
Pennant
Prelate
Richmound
Sceptre
Shackleton
Stewart Valley
Success
Tompkins
Webb
Rural municipalities
RM No. 137 Swift Current
RM No. 138 Webb
RM No. 139 Gull Lake
RM No. 141 Big Stick
RM No. 142 Enterprise
RM No. 167 Saskatchewan Landing
RM No. 168 Riverside
RM No. 169 Pittville
RM No. 171 Fox Valley
RM No. 228 Lacadena
RM No. 229 Miry Creek
RM No. 230 Clinworth
RM No. 231 Happyland
RM No. 232 Deer Forks
RM No. 257 Monet
RM No. 259 Snipe Lake
RM No. 260 Newcombe
RM No. 261 Chesterfield
Indian reserves
Carry the Kettle Nakoda Nation
Carry the Kettle 76-33
Carry the Kettle 76-37
Carry the Kettle 76-38
Unincorporated communities
Ham
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https://en.wikipedia.org/wiki/Division%20No.%209%2C%20Saskatchewan
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Division No. 9, Canada, is one of the eighteen census divisions within the province of Saskatchewan, as defined by Statistics Canada. It is located in the eastern part of the province, bordering Manitoba. The most populous community in this division is Yorkton.
Demographics
In the 2021 Census of Population conducted by Statistics Canada, Division No. 9 had a population of living in of its total private dwellings, a change of from its 2016 population of . With a land area of , it had a population density of in 2021.
Census subdivisions
The following census subdivisions (municipalities or municipal equivalents) are located within Saskatchewan's Division No. 9.
Cities
Yorkton
Towns
Canora
Kamsack
Norquay
Preeceville
Springside
Sturgis
Villages
Arran
Buchanan
Calder
Ebenezer
Endeavour
Hyas
Invermay
Lintlaw
Pelly
Rama
Rhein
Sheho
Stenen
Theodore
Togo
Rural municipalities
RM No. 241 Calder
RM No. 243 Wallace
RM No. 244 Orkney
RM No. 245 Garry
RM No. 271 Cote
RM No. 273 Sliding Hills
RM No. 274 Good Lake
RM No. 275 Insinger
RM No. 301 St. Philips
RM No. 303 Keys
RM No. 304 Buchanan
RM No. 305 Invermay
RM No. 331 Livingston
RM No. 333 Clayton
RM No. 334 Preeceville
RM No. 335 Hazel Dell
Indian reserves
Cote First Nation
Cote 64
Keeseekoose First Nation
Keeseekoose 66
Keeseekoose 66A
Keeseekoose 66-CA-04
Keeseekoose 66-CA-05
Keeseekoose 66-CA-06
Keeseekoose 66-KE-04
Keeseekoose 66-KE-05
The Key First Nation
The Key 65
See also
List of cens
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https://en.wikipedia.org/wiki/Division%20No.%2010%2C%20Saskatchewan
|
Division No. 10 is one of eighteen census divisions in the province of Saskatchewan, Canada, as defined by Statistics Canada. It is located in the east-central part of the province. The most populous community in this division is Wynyard.
Demographics
In the 2021 Census of Population conducted by Statistics Canada, Division No. 10 had a population of living in of its total private dwellings, a change of from its 2016 population of . With a land area of , it had a population density of in 2021.
Census subdivisions
The following census subdivisions (municipalities or municipal equivalents) are located within Saskatchewan's Division No. 10.
Cities
none
Towns
Foam Lake
Ituna
Leroy
Raymore
Wadena
Watson
Wynyard
Villages
Elfros
Hubbard
Jansen
Kelliher
Leross
Lestock
Margo
Punnichy
Quill Lake
Quinton
Semans
Resort villages
Chorney Beach
Leslie Beach
Rural municipalities
RM No. 246 Ituna Bon Accord
RM No. 247 Kellross
RM No. 248 Touchwood
RM No. 276 Foam Lake
RM No. 277 Emerald
RM No. 279 Mount Hope
RM No. 307 Elfros
RM No. 308 Big Quill
RM No. 309 Prairie Rose
RM No. 336 Sasman
RM No. 337 Lakeview
RM No. 338 Lakeside
RM No. 339 Leroy
Source: Statistics Canada 2002 2001 Community Profiles
Indian reserves
Beardy's and Okemasis 96 and 97A
Day Star 87
Fishing Lake 89
Fishing Lake 89A
Gordon 86
Muskowekwan 85
Muskowekwan 85-1
Muskowekwan 85-10
Muskowekwan 85-12
Muskowekwan 85-15
Muskowekwan 85-17
Muskowekwan 85-22
Muskowekwan 85-23
Muskowekwan
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https://en.wikipedia.org/wiki/Division%20No.%2011%2C%20Saskatchewan
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Division No. 11 is one of eighteen census divisions in the province of Saskatchewan, Canada, as defined by Statistics Canada. It is located in the central part of the province and includes the largest city in the province, Saskatoon.
Demographics
In the 2021 Census of Population conducted by Statistics Canada, Division No. 11 had a population of living in of its total private dwellings, a change of from its 2016 population of . With a land area of , it had a population density of in 2021.
Census subdivisions
The following census subdivisions (municipalities or municipal equivalents) are located within Saskatchewan's Division No. 11.
Cities
Martensville
Saskatoon
Warman
Towns
Allan
Colonsay
Dalmeny
Davidson
Dundurn
Govan
Hanley
Imperial
Langham
Lanigan
Nokomis
Osler
Outlook
Watrous
Villages
Bladworth
Bradwell
Broderick
Clavet
Drake
Duval
Elbow
Glenside
Kenaston
Liberty
Loreburn
Hawarden
Meacham
Plunkett
Simpson
Strongfield
Viscount
Young
Zelma
Resort villages
Etters Beach
Manitou Beach
Shields
Thode
Rural municipalities
RM No. 250 Last Mountain Valley
RM No. 251 Big Arm
RM No. 252 Arm River
RM No. 253 Willner
RM No. 254 Loreburn
RM No. 280 Wreford
RM No. 281 Wood Creek
RM No. 282 McCraney
RM No. 283 Rosedale
RM No. 284 Rudy
RM No. 310 Usborne
RM No. 312 Morris
RM No. 313 Lost River
RM No. 314 Dundurn
RM No. 340 Wolverine
RM No. 341 Viscount
RM No. 342 Colonsay
RM No. 343 Blucher
RM No. 344 Corman Park
Indian reserves
Whitecap
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https://en.wikipedia.org/wiki/Division%20No.%2012%2C%20Saskatchewan
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Division No. 12 is one of the eighteen census divisions in the province of Saskatchewan, Canada, as defined by Statistics Canada. It is located in the west-central part of the province. The most populous community in this division is Battleford.
Demographics
In the 2021 Canadian census conducted by Statistics Canada, Division No. 12 had a population of living in of its total private dwellings, a change of from its 2016 population of . With a land area of , it had a population density of in 2021.
Census subdivisions
The following census subdivisions (municipalities or municipal equivalents) are located within Saskatchewan's Division No. 12.
Cities
none
Towns
Battleford
Biggar
Delisle
Rosetown
Zealandia
Villages
Asquith
Conquest
Dinsmore
Harris
Kinley
Macrorie
Milden
Perdue
Tessier
Vanscoy
Wiseton
Rural municipalities
RM No. 285 Fertile Valley
RM No. 286 Milden
RM No. 287 St. Andrews
RM No. 288 Pleasant Valley
RM No. 315 Montrose
RM No. 316 Harris
RM No. 317 Marriott
RM No. 318 Mountain View
RM No. 345 Vanscoy
RM No. 346 Perdue
RM No. 347 Biggar
RM No. 376 Eagle Creek
RM No. 377 Glenside
RM No. 378 Rosemount
RM No. 408 Prairie
RM No. 438 Battle River
Indian reserves
Grizzly Bear's Head 110 and Lean Man 111
Mosquito 109
Red Pheasant 108
Sweet Grass 113
Sweet Grass 113-M16
See also
List of census divisions of Saskatchewan
List of communities in Saskatchewan
Notes
References
Division No. 12, Saskatchewan Statistics Canada
12
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https://en.wikipedia.org/wiki/Division%20No.%2013%2C%20Saskatchewan
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Division No. 13 is one of eighteen census divisions in the province of Saskatchewan, Canada, as defined by Statistics Canada. It is located in the western part of the province, bordering Alberta. The most populous community in this division is Kindersley.
Demographics
In the 2021 Census of Population conducted by Statistics Canada, Division No. 13 had a population of living in of its total private dwellings, a change of from its 2016 population of . With a land area of , it had a population density of in 2021.
Census subdivisions
The following census subdivisions (municipalities or municipal equivalents) are located within Saskatchewan's Division No. 13.
Cities
none
Towns
Cut Knife
Kerrobert
Kindersley
Luseland
Macklin
Scott
Unity
Wilkie
Villages
Brock
Coleville
Denzil
Dodsland
Flaxcombe
Landis
Major
Marengo
Marsden
Neilburg
Netherhill
Plenty
Ruthilda
Senlac
Smiley
Tramping Lake
Rural municipalities
RM No. 290 Kindersley
RM No. 292 Milton
RM No. 319 Winslow
RM No. 320 Oakdale
RM No. 321 Prairiedale
RM No. 322 Antelope Park
RM No. 349 Grandview
RM No. 350 Mariposa
RM No. 351 Progress
RM No. 352 Heart's Hill
RM No. 379 Reford
RM No. 380 Tramping Lake
RM No. 381 Grass Lake
RM No. 382 Eye Hill
RM No. 409 Buffalo
RM No. 410 Round Valley
RM No. 411 Senlac
RM No. 439 Cut Knife
RM No. 440 Hillsdale
RM No. 442 Manitou Lake
Indian reserves
Indian Reserve - Little Pine 116
Indian Reserve - Poundmaker 114
See also
List of census divisions of Saskat
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https://en.wikipedia.org/wiki/Division%20No.%2014%2C%20Saskatchewan
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Division No. 14 is one of eighteen census divisions in the province of Saskatchewan, Canada, as defined by Statistics Canada. It is located on the northern portion of Southeast Saskatchewan, bordering Manitoba. The most populous community in this division is the city of Melfort. Other important communities are the towns of Nipawin and Tisdale.
Demographics
In the 2021 Census of Population conducted by Statistics Canada, Division No. 14 had a population of living in of its total private dwellings, a change of from its 2016 population of . With a land area of , it had a population density of in 2021.
Census subdivisions
The following census subdivisions (municipalities or municipal equivalents) are located within Saskatchewan's Division No. 14.
Cities
Melfort
Towns
Arborfield
Carrot River
Choiceland
Hudson Bay
Kelvington
Naicam
Nipawin
Porcupine Plain
Rose Valley
Star City
Tisdale
Villages
Archerwill
Aylsham
Bjorkdale
Codette
Fosston
Love
Mistatim
Pleasantdale
Ridgedale
Smeaton
Spalding
Valparaiso
Weekes
White Fox
Zenon Park
Resort villages
Tobin Lake
Rural municipalities
RM No. 366 Kelvington
RM No. 367 Ponass Lake
RM No. 368 Spalding
RM No. 394 Hudson Bay
RM No. 395 Porcupine
RM No. 397 Barrier Valley
RM No. 398 Pleasantdale
RM No. 426 Bjorkdale
RM No. 427 Tisdale
RM No. 428 Star City
RM No. 456 Arborfield
RM No. 457 Connaught
RM No. 458 Willow Creek
RM No. 486 Moose Range
RM No. 487 Nipawin
RM No. 488 Torch River
Indian reserves
Carrot River
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https://en.wikipedia.org/wiki/Division%20No.%2015%2C%20Saskatchewan
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Division No. 15 is one of eighteen census divisions in the province of Saskatchewan, Canada, as defined by Statistics Canada. It is located in the north-central part of the province. The most populous community in this division is Prince Albert.
Demographics
In the 2021 Census of Population conducted by Statistics Canada, Division No. 15 had a population of living in of its total private dwellings, a change of from its 2016 population of . With a land area of , it had a population density of in 2021.
Census subdivisions
The following census subdivisions (municipalities or municipal equivalents) are located within Saskatchewan's Division No. 15.
Cities
Humboldt
Prince Albert
Melfort
Towns
Aberdeen
Birch Hills
Bruno
Cudworth
Duck Lake
Hague
Kinistino
Rosthern
St. Brieux
Vonda
Wakaw
Waldheim
Villages
Albertville
Alvena
Annaheim
Beatty
Christopher Lake
Englefeld
Hepburn
Laird
Lake Lenore
Meath Park
Middle Lake
Muenster
Paddockwood
Pilger
Prud'Homme
St. Benedict
St. Gregor
St. Louis
Weirdale
Weldon
Resort villages
Candle Lake
Wakaw Lake
Rural municipalities
RM No. 369 St. Peter
RM No. 370 Humboldt
RM No. 371 Bayne
RM No. 372 Grant
RM No. 373 Aberdeen
RM No. 399 Lake Lenore
RM No. 400 Three Lakes
RM No. 401 Hoodoo
RM No. 402 Fish Creek
RM No. 403 Rosthern
RM No. 404 Laird
RM No. 429 Flett's Springs
RM No. 430 Invergordon
RM No. 431 St. Louis
RM No. 459 Kinistino
RM No. 460 Birch Hills
RM No. 461 Prince Albert
RM No. 463 Duck Lake
RM No. 490 Garden
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https://en.wikipedia.org/wiki/Division%20No.%2016%2C%20Saskatchewan
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Division No. 16 is one of eighteen census divisions in the province of Saskatchewan, Canada, as defined by Statistics Canada. It is located in the north-central part of the province. The most populous community in this division is North Battleford.
Demographics
In the 2021 Census of Population conducted by Statistics Canada, Division No. 16 had a population of living in of its total private dwellings, a change of from its 2016 population of . With a land area of , it had a population density of in 2021.
Census subdivisions
The following census subdivisions (municipalities or municipal equivalents) are located within Saskatchewan's Division No. 16.
Cities
North Battleford
Towns
Big River
Blaine Lake
Hafford
Radisson
Shellbrook
Spiritwood
Villages
Borden
Canwood
Debden
Denholm
Krydor
Leask
Leoville
Marcelin
Maymont
Medstead
Parkside
Richard
Ruddell
Shell Lake
Speers
Resort villages
Big Shell
Echo Bay
Pebble Baye
Rural municipalities
RM No. 405 Great Bend
RM No. 406 Mayfield
RM No. 434 Blaine Lake
RM No. 435 Redberry
RM No. 436 Douglas
RM No. 437 North Battleford
RM No. 464 Leask
RM No. 466 Meeting Lake
RM No. 467 Round Hill
RM No. 493 Shellbrook
RM No. 494 Canwood
RM No. 496 Spiritwood
RM No. 497 Medstead
RM No. 555 Big River
Crown colonies
North Battleford Crown Colony
Unorganized areas
Prince Albert National Park
Indian reserves
Indian Reserve --Ahtahkakoop 104
Indian Reserve --Big River 118
Indian Reserve --Chitek Lake 191
Indian Reser
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https://en.wikipedia.org/wiki/Division%20No.%2017%2C%20Saskatchewan
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Division No. 17 is one of eighteen census divisions in the province of Saskatchewan, Canada, as defined by Statistics Canada. It is located in the west-northwest part of the province, bordering Alberta. The most populous community in this division is the interprovincial city of Lloydminster. Another important population centre is the town of Meadow Lake.
Demographics
In the 2021 Census of Population conducted by Statistics Canada, Division No. 17 had a population of living in of its total private dwellings, a change of from its 2016 population of . With a land area of , it had a population density of in 2021.
Census subdivisions
The following census subdivisions (municipalities or municipal equivalents) are located within Saskatchewan's Division No. 17.
Cities
Lloydminster
Meadow Lake
Towns
Lashburn
Maidstone
Marshall
St. Walburg
Turtleford
Villages
Dorintosh
Edam
Glaslyn
Goodsoil
Loon Lake
Makwa
Meota
Mervin
Paradise Hill
Paynton
Pierceland
Waseca
Resort villages
Aquadeo
Cochin
Greig Lake
Kivimaa-Moonlight Bay
Metinota
Rural municipalities
RM No. 468 Meota
RM No. 469 Turtle River
RM No. 470 Paynton
RM No. 471 Eldon
RM No. 472 Wilton
RM No. 498 Parkdale
RM No. 499 Mervin
RM No. 501 Frenchman Butte
RM No. 502 Brittania
RM No. 561 Loon Lake
RM No. 588 Meadow Lake
RM No. 622 Beaver River
Indian reserves
Big Island Lake Cree Nation
Eagles Lake 165C
Flying Dust First Nation 105
Makaoo 120
Makwa Lake 129
Makwa Lake 129A
Makwa Lake 129B
Makwa L
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https://en.wikipedia.org/wiki/Division%20No.%2018%2C%20Saskatchewan
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Division No. 18, Saskatchewan, Canada, is one of the eighteen Statistics Canada census divisions within the province, occupying the northern half of the province. The census division is coextensive with the Northern Saskatchewan Administration District (NSAD).
The census division is the largest in the province terms of area at , representing 46 per cent of the province's entire area of .
The most populous communities in the census division are La Ronge and La Loche with populations of 2,743 and 2,611 respectively.
Demographics
In the 2021 Census of Population conducted by Statistics Canada, Division No. 18 had a population of living in of its total private dwellings, a change of from its 2016 population of . With a land area of , it had a population density of in 2021.
Census subdivisions
Division No. 18 has 58 census subdivisions, of which 24 are municipalities (including a portion of the City of Flin Flon, a city bisected by the Saskatchewan-Manitoba border, 2 northern towns, 11 northern villages and 10 northern hamlets), 32 are First Nations communities (31 Indian reserves and an Indian settlement), an unincorporated northern settlement and the unorganized balance of Division No. 18. All municipalities within the census division, except for the Northern Hamlet of Black Point, are recognized as census subdivisions.
Cities
Northern towns
Northern villages
Northern hamlets
Indian settlements
Indian reserves
Unincorporated communities
A northern settlement i
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https://en.wikipedia.org/wiki/Ren%C3%A9%20Gateaux
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René Eugène Gateaux (; 5 May 1889 – 3 October 1914) was a French mathematician. He is principally known for the Gateaux derivative, used in the calculus of variations and in the theory of optimal control. He died in combat during World War I. Paul Lévy produced a posthumous edition of his works, extending them considerably, in his Leçons d'analyse fonctionnelle of 1922.
Life
Early years
Gateaux was born on at Vitry-le-François, Marne, 222 years after another mathematician, Abraham de Moivre, was born there (de Moivre, being of Huguenot ancestry, fled to London after the Edict of Fontainebleau of 1685). His father had a small saddlery and upholstery business, and his mother was a seamstress. He was schooled at Reims, and in 1907 entered the École normale supérieure (ENS) on the rue d'Ulm. He was well regarded as one of the most promising mathematicians among his peers. During his time at ENS, Gateaux converted to Roman Catholicism.
Schoolteacher
In 1910, he sat the mathematics examination (being placed 11th of 16 in his year, a somewhat unimpressive result perhaps due to his being so young, according to the ENS's deputy head Émile Borel). He became a teacher at the lycée in Bar-le-Duc, Meuse in 1912, having completed his two years' military service (the first as a private soldier, and the second as a sub-lieutenant, as was required by a 1905 law concerning the service of students from some Grandes Écoles).
At the same time as he took the post at Bar-le-Duc, he started
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https://en.wikipedia.org/wiki/Motorola%20V120c
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The Motorola V120c is a CDMA cell phone sold in 2002 by Motorola. It was mainly used with Verizon and Alltel networks, and included a number of simple features. It had an extendable antenna.
The model existed in black and in silver, but there were other plastic covers from third party manufacturers.
It was very similar to the Motorola v60, but it had only one screen and it was a candybar format phone instead of a clamshell.
A big criticism was the unreliable software that the phone had, with several bugs.
There also exists a TDMA version, called v120t. It had a fixed antenna.
It was rated number three on the list of the ten highest radiation-emitting cell phones.
V120c
Mobile phones introduced in 2002
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https://en.wikipedia.org/wiki/Lake%20Quannapowitt
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Lake Quannapowitt is a lake in Wakefield, Massachusetts. It is one of the two large lakes in Wakefield, the other being the man-made Crystal Lake. The lake is named for Quonopohit, the Naumkeag Native American man who signed a deed to the town that would become Wakefield in 1686. Given its easily accessible location off Route 128 in Middlesex County, Lake Quannapowitt is a popular setting for walkers, joggers, bikers, and in-line skaters. It is the site of many organized races from 5Ks to ultramarathons. Since 1992, Friends of Lake Quannapowitt (FOLQ) has operated as an organization working to fulfill its goal of promoting public awareness and providing long-term protection and enhancement of Lake Quannapowitt and its environs. Large amounts of tar were found in the lake some years ago, a by-product of gas manufacturing from coal. The lake is emptied by the Saugus River.
Lake Quannapowitt (KWAN-ah-POW-it / KWAN-ə-POW-it), which was originally known as Reading Pond, has numerous nicknames today. Some area natives refer to the lake as "Lake Quannapolluted", due to their view of the state of health of the lake, but the Massachusetts Department of Environmental Protection handled only one isolated open case of contamination from the electric company that was remediated in 2008. The two former beaches remain closed to swimming, due to arsenic, which was introduced into the lake in the early 1960s to handle aquatic weeds.
The town common of Wakefield abuts the southeastern shore
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https://en.wikipedia.org/wiki/Reniform
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Reniform is an adjective meaning "kidney-shaped". It may refer to:
Reniform habit, a type of crystal shape
Reniform leaf, a plant leaf shape
Reniform seed, a plant seed shape
Reniform stigma, a spot on the wings of certain moths
See also
Runiform (disambiguation)
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https://en.wikipedia.org/wiki/SBB-CFF-FFS%20RBDe%20560
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The RBDe 560 (in the old naming style, the RBDe 4/4) and its derivatives provide motive power for S-Bahn, suburban, and regional traffic on the Swiss Federal Railways (SBB) network. The derivative versions belong to the SBB as well as various private railroads. The locomotive and its matching Bt model Steuerwagen (translation: control car/cab car/driving trailer) form compositions generally known as the Neuer Pendelzug (New Push-pull Train), which is the source of the acronym NPZ. An NPZ trainset usually includes one or more intermediate cars.
General information
In 1984 four pre-series sets (each consisting of a motor car and a driving trailer) were delivered. Ordered in 1981, they originally bore the RBDe 4/4 designation and road numbers 2100-2103. All four trainsets (RBDe 560 + Bt) were delivered in different color schemes, one of which was the livery used for the main series (blue over white sides, yellow doors, and red faces). The striking contrast to the green color scheme of previous SBB passenger stock led to the name Kolibri (Hummingbird), which is, however, rarely used. Nearly all the RBDe 560 sets have been named after smaller municipalities along the lines served by these trainset received the appropriate coat of arms.
A full order for 80 trainsets followed. A few years later an additional order for a further 42 trainsets was placed. 6 trainsets were ordered by private railroads (Südostbahn (SOB), PBr, MThB, Montafonerbahn, etc.), resulting in a total productio
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https://en.wikipedia.org/wiki/Haplogroup%20E%20%28mtDNA%29
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In human mitochondrial genetics, haplogroup E is a human mitochondrial DNA (mtDNA) haplogroup typical for the Malay Archipelago. It is a subgroup of haplogroup M9.
Origin
Two contrasting proposals have been made for the location and time of the origin of Haplogroup E.
One view is that the clade was formed over 30,000 years ago, around the time of the Last Glacial Maximum, on the northeast coast of Sundaland (near modern Borneo).
In this model, the haplogroup was dispersed by rising sea levels during the Late Glacial period.
In 2014, the mitochondrial DNA of an 8,000-year-old skeleton found on Liang Island, one of the Matsu Islands off the southeast China coast, was found to belong to Haplogroup E, with two of the four mutations characteristic of the E1 subgroup.
From this, Ko and colleagues argue that Haplogroup E arose 8,000 to 11,000 years ago near the north Fujian coast, travelled to Taiwan with Neolithic settlers 6,000 years ago, and from there spread to Maritime Southeast Asia with the Austronesian language dispersal.
Soares et al caution against over-emphasizing a single sample, and maintain that a constant molecular clock implies the earlier date (and more southerly origin) remains more likely.
Distribution
Haplogroup E is found throughout Maritime Southeast Asia.
It is nearly absent from mainland East Asia, where its sister group M9a (also found in Japan) is common.
In particular, it is found among speakers of Austronesian languages, and it is rare even in Southea
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https://en.wikipedia.org/wiki/Human%20%CE%B2-globin%20locus
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The human β-globin locus is composed of five genes located on a short region of chromosome 11, responsible for the creation of the beta parts (roughly half) of the oxygen transport protein Haemoglobin. This locus contains not only the beta globin gene but also delta, gamma-A, gamma-G, and epsilon globin. Expression of all of these genes is controlled by single locus control region (LCR), and the genes are differentially expressed throughout development.
The order of the genes in the beta-globin cluster is: 5' - epsilon – gamma-G – gamma-A – delta – beta - 3'.
The arrangement of the genes directly reflects the temporal differentiation of their expression during development, with the early-embryonic stage version of the gene located closest to the LCR. If the genes are rearranged, the gene products are expressed at improper stages of development.
Expression of these genes is regulated in embryonic erythropoiesis by many transcription factors, including KLF1, which is associated with the upregulation of adult hemoglobin in adult definitive erythrocytes, and KLF2, which is vital to the expression of embryonic hemoglobin.
HBB complex
Many CRMs have been mapped within the cluster of genes encoding β-like globins expressed in embryonic (HBE1), fetal (HBG1 and HBG2), and adult (HBB and HBD) erythroid cells. All are marked by DNase I hypersensitive sites and footprints, and many are bound by GATA1 in peripheral blood derived erythroblasts (PBDEs). A DNA segment located between th
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https://en.wikipedia.org/wiki/Hemoglobin%20subunit%20beta
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Hemoglobin subunit beta (beta globin, β-globin, haemoglobin beta, hemoglobin beta) is a globin protein, coded for by the HBB gene, which along with alpha globin (HBA), makes up the most common form of haemoglobin in adult humans, hemoglobin A (HbA). It is 147 amino acids long and has a molecular weight of 15,867 Da. Normal adult human HbA is a heterotetramer consisting of two alpha chains and two beta chains.
HBB is encoded by the HBB gene on human chromosome 11. Mutations in the gene produce several variants of the proteins which are implicated with genetic disorders such as sickle-cell disease and beta thalassemia, as well as beneficial traits such as genetic resistance to malaria. At least 50 disease-causing mutations in this gene have been discovered.
Gene locus
HBB protein is produced by the gene HBB which is located in the multigene locus of β-globin locus on chromosome 11, specifically on the short arm position 15.4. Expression of beta globin and the neighbouring globins in the β-globin locus is controlled by single locus control region (LCR), the most important regulatory element in the locus located upstream of the globin genes. The normal allelic variant is 1600 base pairs (bp) long and contains three exons. The order of the genes in the beta-globin cluster is 5' - epsilon – gamma-G – gamma-A – delta – beta - 3'.
Interactions
HBB interacts with Haemoglobin, alpha 1 (HBA1) to form haemoglobin A, the major haemoglobin in adult humans. The interaction is two-fol
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https://en.wikipedia.org/wiki/Synexpression
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Synexpression is a type of non-random eukaryotic gene organization. Genes in a synexpression group may not be physically linked, but they are involved in the same process and they are coordinately expressed. It is expected that genes that function in the same process be regulated coordinately. Synexpression groups in particular represent genes that are simultaneously up- or down-regulated, often because their gene products are required in stoichiometric amounts or are protein-complex subunits. It is likely that these gene groups share common cis- and trans-acting control elements to achieve coordinate expression.
Synexpression groups are determined mainly by analysis of expression profiles compiled by the use of DNA microarrays. The use of this technology helps researchers monitor changes in expression patterns for large numbers of genes in a given experiment. Analysis of DNA microarray expression profiles has led to the discovery of a number of genes that are tightly co-regulated.
Identification
The identification of synexpression groups has affected the way some scientists view evolutionary change in higher eukaryotes. Since groups of genes involved in the same biological process often share one or more common control elements, it has been suggested that the differential expression of these synexpression groups in different tissues of organisms can contribute to co-evolution tissues, organs, and appendages. Today it is commonly believed that it is not primarily th
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https://en.wikipedia.org/wiki/Allosteric%20enzyme
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Allosteric enzymes are enzymes that change their conformational ensemble upon binding of an effector (allosteric modulator) which results in an apparent change in binding affinity at a different ligand binding site. This "action at a distance" through binding of one ligand affecting the binding of another at a distinctly different site, is the essence of the allosteric concept. Allostery plays a crucial role in many fundamental biological processes, including but not limited to cell signaling and the regulation of metabolism. Allosteric enzymes need not be oligomers as previously thought, and in fact many systems have demonstrated allostery within single enzymes.
In biochemistry, allosteric regulation (or allosteric control) is the regulation of a protein by binding an effector molecule at a site other than the enzyme's active site.
The site to which the effector binds is termed the allosteric site. Allosteric sites allow effectors to bind to the protein, often resulting in a conformational change involving protein dynamics. Effectors that enhance the protein's activity are referred to as allosteric activators, whereas those that decrease the protein's activity are called allosteric inhibitors.
Allosteric regulations are a natural example of control loops, such as feedback from downstream products or feedforward from upstream substrates. Long-range allostery is especially important in cell signaling. Allosteric regulation is also particularly important in the cell's abili
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https://en.wikipedia.org/wiki/Douglas%20Barber
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Douglas Barber, is a Canadian businessman. He is a founder and former President and CEO of Gennum Corporation, a Canadian public company that designs, manufactures and markets semiconductors and semiconductor-based products.
Early life and education
Born in Saskatchewan, Barber received a Bachelor of Science degree in 1959 and a Master of Science degree in 1960 both in Electrical Engineering from the University of Saskatchewan. He received a D.I.C. and Ph.D. in Electrical Engineering in 1965 from Imperial College London.
Career
In 1965, he started his career as a research engineer, manager at Westinghouse Canada. In 1973, he co-founded Linear Technology Inc. and was President and COO. In 1990, Linear Technology Inc. was rebranded as Gennum Corporation. Under his leadership, Gennum Corporation grew to over 500 employees, with subsidiaries in Japan and the United Kingdom. Gennum Corporation was later bought by Semtech for $500 million in 2012.
In 1968, Barber started teaching at McMaster University in the Department of Engineering Physics as a part-time Assistant Professor. He was appointed a part-time Associate Professor in 1974 and a part-time Professor in 1981. He retired in 1994.
Barber was actively involved in Microelectronics initiatives in Canada including the Canadian Semiconductor Technology Conference, the Canadian Microelectronics Corporation, the Sectoral Skills Council, the Canadian Semiconductor Design Association, Micronet and the Strategic Semiconductor C
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https://en.wikipedia.org/wiki/Distributed%20minimum%20spanning%20tree
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The distributed minimum spanning tree (MST) problem involves the construction of a minimum spanning tree by a distributed algorithm, in a network where nodes communicate by message passing. It is radically different from the classical sequential problem, although the most basic approach resembles Borůvka's algorithm. One important application of this problem is to find a tree that can be used for broadcasting. In particular, if the cost for a message to pass through an edge in a graph is significant, an MST can minimize the total cost for a source process to communicate with all the other processes in the network.
The problem was first suggested and solved in time in 1983 by Gallager et al., where is the number of vertices in the graph. Later, the solution was improved to and finally
where D is the network, or graph diameter. A lower bound on the time complexity of the solution has been eventually shown to be
Overview
The input graph is considered to be a network, where vertices are independent computing nodes and edges are communication links. Links are weighted as in the classical problem.
At the beginning of the algorithm, nodes know only the weights of the links which are connected to them. (It is possible to consider models in which they know more, for example their neighbors' links.)
As the output of the algorithm, every node knows which of its links belong to the minimum spanning tree and which do not.
MST in message-passing model
The message-passing mode
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https://en.wikipedia.org/wiki/Jazz%20Semiconductor
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Jazz Semiconductor is a semiconductor wafer foundry that is a wholly owned United States subsidiary of Israel-based Tower Semiconductor. Its customers include developers of wireless, optical networking, power management, storage, and aerospace/defense applications. Headquartered in Newport Beach, California, Jazz passed through a number of acquisitions including the short-lived company Acquicor Technology, which renamed itself Jazz Technologies and then sold it two years later.
History
Jazz Semiconductor Systems was founded on February 15, 2002, renamed itself Specialtysemi, Inc. later in February 2002 and to Jazz Semiconductor, Inc. in May 2002. Prior to March 12, 2002, it was Conexant's fabrication facility, as subsidiary Newport Fab, LLC. It was initially funded by Conexant and affiliates of the Carlyle Group. Shu Li was its chief executive since May 2002. RF Micro Devices invested $60 million in October 2002, and became a customer.
Jazz reported losses for each year of 2003, 2004, and 2005.
It filed for an attempted initial public offering (IPO) several times from January 2004 through July 2006, to be listed on Nasdaq under symbol JAZZ, but failed to attract investor interest.
Acquicor Management LLC was jointly formed by Gil Amelio, Steve Wozniak and Ellen Hancock, all of whom had worked for Apple Computer.
Founded in August 2005, Amelio was Acquicor's chief executive.
Acquicor Technology was known as a blank-check company: it existed only to make acquisitions in unsp
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https://en.wikipedia.org/wiki/Friendly%20Fa%24cism
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Friendly Fa$cism is a full-length album by industrial/hip hop artists Consolidated, released in 1991.
"Brutal Equation" and "Unity of Oppression" were alternative rock hits on MTV. The album peaked at #6 on the CMJ Radio Top 150.
The name comes from Friendly Fascism: The New Face of Power in America, the title of a 1980 book by political scientist Bertram Gross which lays out the form of "creeping fascism" that Gross feared might come to pass in the United States.
Critical reception
Trouser Press wrote that "the insufferably self-righteous tone makes the disc hard to endure." Alternative Rock called the album "a hard-hitting soundtrack of hip-hop, funk, soul, and hard rock.
Track listing (CD)
"Zero" – 0:21
"Brutal Equation" – 4:13
"Our Leader" – 1:01
"Unity Of Oppression" – 4:01
"The Sexual Politics Of Meat" – 3:43
"Typical Male" – 5:18
"Entertainment Tonight" – 0:40
"Dominion" – 4:04
"Friendly Fascism" – 5:01
"College Radio" – 1:27
"We Gotta Have Peace" – 3:30
"Meat Kills" – 3:34
"Stoned" – 6:54
"Your Body Belongs To The State" – 1:49
"Crusading Rap Guys" – 5:29
"Murder One" – 2:52
"White American Male '91 (The Truth Hurts) Part 2" – 5:12
"Music Has No Meaning" – 5:17
Track listing (Vinyl)
Side One
"Zero" – 0:21
"Brutal Equation" – 4:13
"Our Leader" – 1:01
"Unity Of Oppression" – 4:01
"The Sexual Politics Of Meat" – 3:43
"Typical Male" – 5:18
"Entertainment Tonight" – 0:40
"Friendly Fascism" – 5:01
Side Two
"We Gotta
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https://en.wikipedia.org/wiki/List%20of%20Kiss%20members
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Kiss is an American hard rock band from New York City, US. Formed in January 1973, the group originally featured rhythm guitarist Paul Stanley, bassist Gene Simmons, lead guitarist Ace Frehley and drummer Peter Criss, all of whom contributed to vocals. The band's lineup remained stable for seven years, before Criss left on May 18, 1980 after an injury and increasing personal tensions. He was replaced by Eric Carr, after Anton Fig filled in for 1979's Dynasty and 1980's Unmasked. Two years later Frehley also left the band.
Frehley was replaced by Vinnie Vincent, who debuted with the group in December 1982 after contributing to Creatures of the Night earlier in the year. Vincent also performed on Lick It Up, but was fired at the end of the album's promotional touring cycle in March 1984 for what Simmons called "unethical behavior". He was replaced the following month by Mark St. John, who performed on Animalize. After contracting arthritis which made it difficult to perform, he was temporarily replaced on the Animalize World Tour by Bruce Kulick; St. John's condition improved, performing two full shows and one partial show with Kiss in November of 1984. However, it quickly became apparent that Kulick was a more natural fit musically than St. John. As a result, the replacement was made permanent in December and St. John was fired.
The lineup featuring Kulick was the most stable since the band's first incarnation, only ending on November 24, 1991 when Carr died of heart cancer.
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https://en.wikipedia.org/wiki/Lego%20Aquazone
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Lego Aquazone (stylized as LEGO Aquazone) was a Lego theme that was launched by The Lego Group in 1995 and discontinued in 1998. It centred on undersea miners and their enemies searching for crystals. It consisted of submarine vehicles and aquatic animals, with minifigures designed for submarine adventures.
Overview
Aquazone was a Lego product line that focused on undersea adventures. It launched in 1995 with two sub-themes named Aquanauts and Aquasharks, which were released simultaneously. This was followed by the release of three additional sub-themes: Aquaraiders in 1997, Hydronauts in 1998 and Stingrays in 1998. Aqua Raiders was launched later in 2007 as a standalone theme.
Sub-themes
Aquanauts (1995–1996)
The Aquanauts were the heroes of this sub-theme, which launched in 1995 and continued production until 1996. They were defined as a group of undersea miners. The backstory of the theme focused on the Aquanauts exploring the ocean in search of crystals to investigate their properties. Their base was called the Neptune Discovery Lab. They also used underwater vehicles, such as the Crystal Explorer Sub and the Crystal Crawler to do their work.
1728/6145 Crystal Crawler/Aquanaut Turbo Amphi
1749/1806 Hydronaut Paravane
1822 Sea Claw 7
6125 Sea Sprint 9/Aquanaut Octopod
6175 Crystal Explorer Sub/Aquanaut DSRV II
6195 Neptune Discovery Lab/Aqua Dome 7
Aquasharks (1995–1996, 1998)
The Aquasharks sub-theme was launched alongside Aquanauts in 1995 and continued
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https://en.wikipedia.org/wiki/Gary%20Locke%20%28English%20footballer%29
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Gary Robert Locke (born 12 July 1954) is an English former footballer born in Willesden, London, who played in the Football League for Chelsea and Crystal Palace, and in the Allsvenskan for Halmstads BK.
Locke was born in Park Royal but moved to Willesden as a six-year-old with his family in 1960.
A right-back, Locke spent much of his career at Chelsea, making more than 300 league and cup appearances for the west London side between 1972 and 1983. He turned professional in July 1971, made his debut in a 3–1 win against Coventry City in the First Division on 30 September 1972, and scored his first goal for the club against the same opponents on 24 August 1974. Capable of making overlapping attacking runs up the wing, he was chosen as Chelsea Player of the Year in the 1973–74 season.
In 1983, after a spell on loan at the club, he moved to Crystal Palace on a permanent basis, making another 101 league and cup appearances in total, before spending the 1986 season in Sweden with Halmstads BK.
In 1987 Locke was brought to New Zealand by newly promoted National League club Napier City Rovers. He captained the team in 1988 and helped the club win the National League championship in 1989. Locke was left out of Napier's squad for the 1992 National League campaign.
References
External links
1954 births
Living people
Footballers from Willesden
English men's footballers
Men's association football fullbacks
Chelsea F.C. players
Crystal Palace F.C. players
Halmstads BK players
Napier
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